U.S. patent application number 14/838304 was filed with the patent office on 2016-03-03 for development of a protein-based biotherapeutic agent that penetrates cell-membrane and induces anti-tumor effect in solid tumors - improved cell-permeable suppressor of cytokine signaling (icp-socs3) proteins, polynucleotides encoding the same, and anti-tumor compositions comprising the same. The applicant listed for this patent is Cellivery Therapeutics, Inc., DAEWOONG JO. Invention is credited to Young Sil CHOI, Daewoong JO, Ju Hyun NAM, Seul Mee SHIN.
Application Number | 20160060314 14/838304 |
Document ID | / |
Family ID | 55401724 |
Filed Date | 2016-03-03 |
United States Patent Application | 20160060314 |
Kind Code | A1 |
JO; Daewoong ; et al. | March 3, 2016 |
In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance. Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. Previously developed hydrophobic CPPs, named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD), are able to deliver biologically active proteins into a variety of cells and tissues. Various cargo proteins fused to these CPPs have been used to test the functional and/or therapeutic efficacy of protein transduction. The recombinant proteins consisting of suppressor of cytokine signaling 3 (CP-SOCS3) protein fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. However, CP-SOCS3 fusion proteins expressed in bacteria cells were hard to be purified in soluble form. To address these critical limitations, CPP sequences called advanced MTDs (aMTDs) have been developed in this art. This is accomplished by (i) analyzing previous developed hydrophobic CPP sequences to identify specific critical factors (CFs) that affect intracellular delivery potential and (ii) constructing artificial aMTD sequences satisfied for each critical factor. In addition, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. These recombinant SOCS3 proteins fused to aMTD/SD having much higher solubility/yield and cell-/tissue-permeability have been named as improved cell-permeable SOCS3 (iCP-SOCS3) proteins. Previously developed CP-SOCS3 proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. In the present art, iCP-SOCS3 proteins have been tested for use as anti-cancer agents in the treatment of various cancers likes gastric, colorectal and breast cancer, and glioblastoma. Since SOCS3 is frequently deleted in and loss of SOCS3 in tumors promotes resistance to apoptosis and proliferation, we reasoned that iCP-SOCS3 could be used as a protein-based intracellular replacement therapy for the treatment of various cancers. The results demonstrated in this art support the reasoning: treatment of cancer cells with iCP-SOCS3 results in reduced cancer cell viability, enhanced apoptosis of solid tumors including gastric, colorectal and breast cancer, and glioblastoma and loss of cell migration/invasion potential. Furthermore, iCP-SOCS3 inhibits the growth of gastric and colorectal tumors in a subcutaneous xenografts model. In the present invention with iCP-SOCS3, where SOCS3 is fused to an empirically determined combination of newly developed aMTD and customized SD, macromolecule intracellular transduction technology (MITT) enabled by the advanced MTDs may provide novel protein therapy against various tumors such as gastric cancer, colorectal cancer, glioblastoma, and breast cancer.
Inventors: | JO; Daewoong; (Brentwood, TN) ; CHOI; Young Sil; (Seoul, KR) ; SHIN; Seul Mee; (Seoul, KR) ; NAM; Ju Hyun; (Seoul, KR) | ||||||||||
Applicant: |
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Family ID: | 55401724 | ||||||||||
Appl. No.: | 14/838304 | ||||||||||
Filed: | August 27, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
62042493 | Aug 27, 2014 | |||
Current U.S. Class: | 530/327 ; 530/350; 536/23.4 |
Current CPC Class: | C07K 7/06 20130101; A61K 38/1761 20130101; A61K 38/10 20130101; C07K 14/4702 20130101; C07K 14/4703 20130101; C07K 14/51 20130101; C07K 2319/00 20130101; C07K 2319/01 20130101; C07K 2319/21 20130101; C07K 14/47 20130101; C07K 2319/10 20130101; A61K 38/1709 20130101; C07K 2319/40 20130101; A61K 38/00 20130101; A61K 38/08 20130101; C07K 7/08 20130101 |
International Class: | C07K 14/47 20060101 C07K014/47; C07K 7/08 20060101 C07K007/08 |
Sequence CWU 1
1
490112PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 1Ala
Ala Ala Leu Ala Pro Val Val Leu Ala Leu Pro1 5 10 212PRTArtificial
SequenceAdvanced Macromolecule Transduction Domain (aMTD) Sequences
for Improvement of Cell-Permeability 2Ala Ala Ala Val Pro Leu Leu
Ala Val Val Val Pro1 5 10 312PRTArtificial SequenceAdvanced
Macromolecule Transduction Domain (aMTD) Sequences for Improvement
of Cell-Permeability 3Ala Ala Leu Leu Val Pro Ala Ala Val Leu Ala
Pro1 5 10 412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 4Ala Leu Ala Leu Leu Pro Val Ala Ala Leu Ala Pro1
5 10 512PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 5Ala
Ala Ala Leu Leu Pro Val Ala Leu Val Ala Pro1 5 10 612PRTArtificial
SequenceAdvanced Macromolecule Transduction Domain (aMTD) Sequences
for Improvement of Cell-Permeability 6Val Val Ala Leu Ala Pro Ala
Leu Ala Ala Leu Pro1 5 10 712PRTArtificial SequenceAdvanced
Macromolecule Transduction Domain (aMTD) Sequences for Improvement
of Cell-Permeability 7Leu Leu Ala Ala Val Pro Ala Val Leu Leu Ala
Pro1 5 10 812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 8Ala Ala Ala Leu Val Pro Val Val Ala Leu Leu Pro1
5 10 912PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 9Ala
Val Ala Leu Leu Pro Ala Leu Leu Ala Val Pro1 5 10 1012PRTArtificial
SequenceAdvanced Macromolecule Transduction Domain (aMTD) Sequences
for Improvement of Cell-Permeability 10Ala Val Val Leu Val Pro Val
Leu Ala Ala Ala Pro1 5 10 1112PRTArtificial SequenceAdvanced
Macromolecule Transduction Domain (aMTD) Sequences for Improvement
of Cell-Permeability 11Val Val Leu Val Leu Pro Ala Ala Ala Ala Val
Pro1 5 10 1212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 12Ile Ala Leu Ala Ala Pro Ala Leu Ile Val Ala
Pro1 5 10 1312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 13Ile Val Ala Val Ala Pro Ala Leu Val Ala Leu
Pro1 5 10 1412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 14Val Ala Ala Leu Pro Val Val Ala Val Val Ala
Pro1 5 10 1512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 15Leu Leu Ala Ala Pro Leu Val Val Ala Ala Val
Pro1 5 10 1612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 16Ala Leu Ala Val Pro Val Ala Leu Leu Val Ala
Pro1 5 10 1712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 17Val Ala Ala Leu Pro Val Leu Leu Ala Ala Leu
Pro1 5 10 1812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 18Val Ala Leu Leu Ala Pro Val Ala Leu Ala Val
Pro1 5 10 1912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 19Ala Ala Leu Leu Val Pro Ala Leu Val Ala Val
Pro1 5 10 2012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 20Ala Ile Val Ala Leu Pro Val Ala Val Leu Ala
Pro1 5 10 2112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 21Ile Ala Ile Val Ala Pro Val Val Ala Leu Ala
Pro1 5 10 2212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 22Ala Ala Leu Leu Pro Ala Leu Ala Ala Leu Leu
Pro1 5 10 2312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 23Ala Val Val Leu Ala Pro Val Ala Ala Val Leu
Pro1 5 10 2412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 24Leu Ala Val Ala Ala Pro Leu Ala Leu Ala Leu
Pro1 5 10 2512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 25Ala Ala Val Ala Ala Pro Leu Leu Leu Ala Leu
Pro1 5 10 2612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 26Leu Leu Val Leu Pro Ala Ala Ala Leu Ala Ala
Pro1 5 10 2712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 27Leu Val Ala Leu Ala Pro Val Ala Ala Val Leu
Pro1 5 10 2812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 28Leu Ala Leu Ala Pro Ala Ala Leu Ala Leu Leu
Pro1 5 10 2912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 29Ala Leu Ile Ala Ala Pro Ile Leu Ala Leu Ala
Pro1 5 10 3012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 30Ala Val Val Ala Ala Pro Leu Val Leu Ala Leu
Pro1 5 10 3112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 31Leu Leu Ala Leu Ala Pro Ala Ala Leu Leu Ala
Pro1 5 10 3212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 32Ala Ile Val Ala Leu Pro Ala Leu Ala Leu Ala
Pro1 5 10 3312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 33Ala Ala Ile Ile Val Pro Ala Ala Leu Leu Ala
Pro1 5 10 3412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 34Ile Ala Val Ala Leu Pro Ala Leu Ile Ala Ala
Pro1 5 10 3512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 35Ala Val Ile Val Leu Pro Ala Leu Ala Val Ala
Pro1 5 10 3612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 36Ala Val Leu Ala Val Pro Ala Val Leu Val Ala
Pro1 5 10 3712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 37Val Leu Ala Ile Val Pro Ala Val Ala Leu Ala
Pro1 5 10 3812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 38Leu Leu Ala Val Val Pro Ala Val Ala Leu Ala
Pro1 5 10 3912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 39Ala Val Ile Ala Leu Pro Ala Leu Ile Ala Ala
Pro1 5 10 4012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 40Ala Val Val Ala Leu Pro Ala Ala Leu Ile Val
Pro1 5 10 4112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 41Leu Ala Leu Val Leu Pro Ala Ala Leu Ala Ala
Pro1 5 10 4212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 42Leu Ala Ala Val Leu Pro Ala Leu Leu Ala Ala
Pro1 5 10 4312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 43Ala Leu Ala Val Pro Val Ala Leu Ala Ile Val
Pro1 5 10 4412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 44Ala Leu Ile Ala Pro Val Val Ala Leu Val Ala
Pro1 5 10 4512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 45Leu Leu Ala Ala Pro Val Val Ile Ala Leu Ala
Pro1 5 10 4612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 46Leu Ala Ala Ile Val Pro Ala Ile Ile Ala Val
Pro1 5 10 4712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 47Ala Ala Leu Val Leu Pro Leu Ile Ile Ala Ala
Pro1 5 10 4812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 48Leu Ala Leu Ala Val Pro Ala Leu Ala Ala Leu
Pro1 5 10 4912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 49Leu Ile Ala Ala Leu Pro Ala Val Ala Ala Leu
Pro1 5 10 5012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 50Ala Leu Ala Leu Val Pro Ala Ile Ala Ala Leu
Pro1 5 10 5112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 51Ala Ala Ile Leu Ala Pro Ile Val Ala Leu Ala
Pro1 5 10 5212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 52Ala Leu Leu Ile Ala Pro Ala Ala Val Ile Ala
Pro1 5 10 5312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 53Ala Ile Leu Ala Val Pro Ile Ala Val Val Ala
Pro1 5 10 5412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 54Ile Leu Ala Ala Val Pro Ile Ala Leu Ala Ala
Pro1 5 10 5512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 55Val Ala Ala Leu Leu Pro Ala Ala Ala Val Leu
Pro1 5 10 5612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 56Ala Ala Ala Val Val Pro Val Leu Leu Val Ala
Pro1 5 10 5712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 57Ala Ala Leu Leu Val Pro Ala Leu Val Ala Ala
Pro1 5 10 5812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 58Ala Ala Val Leu Leu Pro Val Ala Leu Ala Ala
Pro1 5 10 5912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 59Ala Ala Ala Leu Ala Pro Val Leu Ala Leu Val
Pro1 5 10 6012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 60Leu Val Leu Val Pro Leu Leu Ala Ala Ala Ala
Pro1 5 10 6112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 61Ala Leu Ile Ala Val Pro Ala Ile Ile Val Ala
Pro1 5 10 6212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 62Ala Leu Ala Val Ile Pro Ala Ala Ala Ile Leu
Pro1 5 10 6312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 63Leu Ala Ala Ala Pro Val Val Ile Val Ile Ala
Pro1 5 10 6412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 64Val Leu Ala Ile Ala Pro Leu Leu Ala Ala Val
Pro1 5 10 6512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 65Ala Leu Ile Val Leu Pro Ala Ala Val Ala Val
Pro1 5 10 6612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 66Val Leu Ala Val Ala Pro Ala Leu Ile Val Ala
Pro1 5 10 6712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 67Ala Ala Leu Leu Ala Pro Ala Leu Ile Val Ala
Pro1 5 10 6812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 68Ala Leu Ile Ala Pro Ala Val Ala Leu Ile Val
Pro1 5 10 6912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 69Ala Ile Val Leu Leu Pro Ala Ala Val Val Ala
Pro1 5 10 7012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 70Val Ile Ala Ala Pro Val Leu Ala Val Leu Ala
Pro1 5 10 7112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 71Leu Ala Leu Ala Pro Ala Leu Ala Leu Leu Ala
Pro1 5 10 7212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 72Ala Ile Ile Leu Ala Pro Ile Ala Ala Ile Ala
Pro1 5 10 7312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 73Ile Ala Leu Ala Ala Pro Ile Leu Leu Ala Ala
Pro1 5 10 7412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 74Ile Val Ala Val Ala Leu Pro Ala Leu Ala Val
Pro1 5 10 7512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 75Val Val Ala Ile Val Leu Pro Ala Leu Ala Ala
Pro1 5 10 7612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 76Ile Val Ala Val Ala Leu Pro Val Ala Leu Ala
Pro1 5 10 7712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 77Ile Val Ala Val Ala Leu Pro Ala Ala Leu Val
Pro1 5 10 7812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 78Ile Val Ala Val Ala Leu Pro Ala Val Ala Leu
Pro1 5 10 7912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 79Ile Val Ala Val Ala Leu Pro Ala Val Leu Ala
Pro1 5 10 8012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 80Val Ile Val Ala Leu Ala Pro Ala
Val Leu Ala Pro1 5 10 8112PRTArtificial SequenceAdvanced
Macromolecule Transduction Domain (aMTD) Sequences for Improvement
of Cell-Permeability 81Ile Val Ala Val Ala Leu Pro Ala Leu Val Ala
Pro1 5 10 8212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 82Ala Leu Leu Ile Val Ala Pro Val Ala Val Ala
Pro1 5 10 8312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 83Ala Val Val Ile Val Ala Pro Ala Val Ile Ala
Pro1 5 10 8412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 84Ala Val Leu Ala Val Ala Pro Ala Leu Ile Val
Pro1 5 10 8512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 85Leu Val Ala Ala Val Ala Pro Ala Leu Ile Val
Pro1 5 10 8612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 86Ala Val Ile Val Val Ala Pro Ala Leu Leu Ala
Pro1 5 10 8712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 87Val Val Ala Ile Val Leu Pro Ala Val Ala Ala
Pro1 5 10 8812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 88Ala Ala Ala Leu Val Ile Pro Ala Ile Leu Ala
Pro1 5 10 8912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 89Val Ile Val Ala Leu Ala Pro Ala Leu Leu Ala
Pro1 5 10 9012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 90Val Ile Val Ala Ile Ala Pro Ala Leu Leu Ala
Pro1 5 10 9112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 91Ile Val Ala Ile Ala Val Pro Ala Leu Val Ala
Pro1 5 10 9212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 92Ala Ala Leu Ala Val Ile Pro Ala Ala Ile Leu
Pro1 5 10 9312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 93Ala Leu Ala Ala Val Ile Pro Ala Ala Ile Leu
Pro1 5 10 9412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 94Ala Ala Ala Leu Val Ile Pro Ala Ala Ile Leu
Pro1 5 10 9512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 95Leu Ala Ala Ala Val Ile Pro Ala Ala Ile Leu
Pro1 5 10 9612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 96Leu Ala Ala Ala Val Ile Pro Val Ala Ile Leu
Pro1 5 10 9712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 97Ala Ala Ile Leu Ala Ala Pro Leu Ile Ala Val
Pro1 5 10 9812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 98Val Val Ala Ile Leu Ala Pro Leu Leu Ala Ala
Pro1 5 10 9912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 99Ala Val Val Val Ala Ala Pro Val Leu Ala Leu
Pro1 5 10 10012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 100Ala Val Val Ala Ile Ala Pro Val Leu Ala Leu
Pro1 5 10 10112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 101Ala Leu Ala Ala Leu Val Pro Ala Val Leu Val
Pro1 5 10 10212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 102Ala Leu Ala Ala Leu Val Pro Val Ala Leu Val
Pro1 5 10 10312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 103Leu Ala Ala Ala Leu Val Pro Val Ala Leu Val
Pro1 5 10 10412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 104Ala Leu Ala Ala Leu Val Pro Ala Leu Val Val
Pro1 5 10 10512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 105Ile Ala Ala Val Ile Val Pro Ala Val Ala Leu
Pro1 5 10 10612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 106Ile Ala Ala Val Leu Val Pro Ala Val Ala Leu
Pro1 5 10 10712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 107Ala Val Ala Ile Leu Val Pro Leu Leu Ala Ala
Pro1 5 10 10812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 108Ala Val Val Ile Leu Val Pro Leu Ala Ala Ala
Pro1 5 10 10912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 109Ile Ala Ala Val Ile Val Pro Val Ala Ala Leu
Pro1 5 10 11012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 110Ala Ile Ala Ile Ala Ile Val Pro Val Ala Leu
Pro1 5 10 11112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 111Ile Leu Ala Val Ala Ala Ile Pro Val Ala Val
Pro1 5 10 11212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 112Ile Leu Ala Ala Ala Ile Ile Pro Ala Ala Leu
Pro1 5 10 11312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 113Leu Ala Val Val Leu Ala Ala Pro Ala Ile Val
Pro1 5 10 11412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 114Ala Ile Leu Ala Ala Ile Val Pro Leu Ala Val
Pro1 5 10 11512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 115Val Ile Val Ala Leu Ala Val Pro Ala Leu Ala
Pro1 5 10 11612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 116Ala Ile Val Ala Leu Ala Val Pro Val Leu Ala
Pro1 5 10 11712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 117Ala Ala Ile Ile Ile Val Leu Pro Ala Ala Leu
Pro1 5 10 11812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 118Leu Ile Val Ala Leu Ala Val Pro Ala Leu Ala
Pro1 5 10 11912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 119Ala Ile Ile Ile Val Ile Ala Pro Ala Ala Ala
Pro1 5 10 12012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 120Leu Ala Ala Leu Ile Val Val Pro Ala Val Ala
Pro1 5 10 12112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 121Ala Leu Leu Val Ile Ala Val Pro Ala Val Ala
Pro1 5 10 12212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 122Ala Val Ala Leu Ile Val Val Pro Ala Leu Ala
Pro1 5 10 12312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 123Ala Leu Ala Ile Val Val Ala Pro Val Ala Val
Pro1 5 10 12412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 124Leu Leu Ala Leu Ile Ile Ala Pro Ala Ala Ala
Pro1 5 10 12512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 125Ala Leu Ala Leu Ile Ile Val Pro Ala Val Ala
Pro1 5 10 12612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 126Leu Leu Ala Ala Leu Ile Ala Pro Ala Ala Leu
Pro1 5 10 12712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 127Ile Val Ala Leu Ile Val Ala Pro Ala Ala Val
Pro1 5 10 12812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 128Val Val Leu Val Leu Ala Ala Pro Ala Ala Val
Pro1 5 10 12912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 129Ala Ala Val Ala Ile Val Leu Pro Ala Val Val
Pro1 5 10 13012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 130Ala Leu Ile Ala Ala Ile Val Pro Ala Leu Val
Pro1 5 10 13112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 131Ala Leu Ala Val Ile Val Val Pro Ala Leu Ala
Pro1 5 10 13212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 132Val Ala Ile Ala Leu Ile Val Pro Ala Leu Ala
Pro1 5 10 13312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 133Val Ala Ile Val Leu Val Ala Pro Ala Val Ala
Pro1 5 10 13412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 134Val Ala Val Ala Leu Ile Val Pro Ala Leu Ala
Pro1 5 10 13512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 135Ala Val Ile Leu Ala Leu Ala Pro Ile Val Ala
Pro1 5 10 13612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 136Ala Leu Ile Val Ala Ile Ala Pro Ala Leu Val
Pro1 5 10 13712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 137Ala Ala Ile Leu Ile Ala Val Pro Ile Ala Ala
Pro1 5 10 13812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 138Val Ile Val Ala Leu Ala Ala Pro Val Leu Ala
Pro1 5 10 13912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 139Val Leu Val Ala Leu Ala Ala Pro Val Ile Ala
Pro1 5 10 14012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 140Val Ala Leu Ile Ala Val Ala Pro Ala Val Val
Pro1 5 10 14112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 141Val Ile Ala Ala Val Leu Ala Pro Val Ala Val
Pro1 5 10 14212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 142Ala Leu Ile Val Leu Ala Ala Pro Val Ala Val
Pro1 5 10 14312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 143Val Ala Ala Ala Ile Ala Leu Pro Ala Ile Val
Pro1 5 10 14412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 144Ile Leu Ala Ala Ala Ala Ala Pro Leu Ile Val
Pro1 5 10 14512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 145Leu Ala Leu Val Leu Ala Ala Pro Ala Ile Val
Pro1 5 10 14612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 146Ala Leu Ala Val Val Ala Leu Pro Ala Ile Val
Pro1 5 10 14712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 147Ala Ala Ile Leu Ala Pro Ile Val Ala Ala Leu
Pro1 5 10 14812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 148Ile Leu Ile Ala Ile Ala Ile Pro Ala Ala Ala
Pro1 5 10 14912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 149Leu Ala Ile Val Leu Ala Ala Pro Val Ala Val
Pro1 5 10 15012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 150Ala Ala Ile Ala Ile Ile Ala Pro Ala Ile Val
Pro1 5 10 15112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 151Leu Ala Val Ala Ile Val Ala Pro Ala Leu Val
Pro1 5 10 15212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 152Leu Ala Ile Val Leu Ala Ala Pro Ala Val Leu
Pro1 5 10 15312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 153Ala Ala Ile Val Leu Ala Leu Pro Ala Val Leu
Pro1 5 10 15412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 154Ala Leu Leu Val Ala Val Leu Pro Ala Ala Leu
Pro1 5 10 15512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 155Ala Ala Leu Val Ala Val Leu Pro Val Ala Leu
Pro1 5 10 15612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 156Ala Ile Leu Ala Val Ala Leu Pro Leu Leu Ala
Pro1 5 10 15712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 157Ile Val Ala Val Ala Leu Val Pro Ala Leu Ala
Pro1 5 10 15812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 158Ile Val Ala Val Ala Leu Leu Pro Ala Leu Ala
Pro1 5 10 15912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain
(aMTD) Sequences for Improvement of Cell-Permeability 159Ile Val
Ala Val Ala Leu Leu Pro Ala Val Ala Pro1 5 10 16012PRTArtificial
SequenceAdvanced Macromolecule Transduction Domain (aMTD) Sequences
for Improvement of Cell-Permeability 160Ile Val Ala Leu Ala Val Leu
Pro Ala Val Ala Pro1 5 10 16112PRTArtificial SequenceAdvanced
Macromolecule Transduction Domain (aMTD) Sequences for Improvement
of Cell-Permeability 161Val Ala Val Leu Ala Val Leu Pro Ala Leu Ala
Pro1 5 10 16212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 162Ile Ala Val Leu Ala Val Ala Pro Ala Val Leu
Pro1 5 10 16312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 163Leu Ala Val Ala Ile Ile Ala Pro Ala Val Ala
Pro1 5 10 16412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 164Val Ala Leu Ala Ile Ala Leu Pro Ala Val Leu
Pro1 5 10 16512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 165Ala Ile Ala Ile Ala Leu Val Pro Val Ala Leu
Pro1 5 10 16612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 166Ala Ala Val Val Ile Val Ala Pro Val Ala Leu
Pro1 5 10 16712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 167Val Ala Ile Ile Val Val Ala Pro Ala Leu Ala
Pro1 5 10 16812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 168Val Ala Leu Leu Ala Ile Ala Pro Ala Leu Ala
Pro1 5 10 16912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 169Val Ala Val Leu Ile Ala Val Pro Ala Leu Ala
Pro1 5 10 17012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 170Ala Val Ala Leu Ala Val Leu Pro Ala Val Val
Pro1 5 10 17112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 171Ala Val Ala Leu Ala Val Val Pro Ala Val Leu
Pro1 5 10 17212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 172Ile Val Val Ile Ala Val Ala Pro Ala Val Ala
Pro1 5 10 17312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 173Ile Val Val Ala Ala Val Val Pro Ala Leu Ala
Pro1 5 10 17412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 174Ile Val Ala Leu Val Pro Ala Val Ala Ile Ala
Pro1 5 10 17512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 175Val Ala Ala Leu Pro Ala Val Ala Leu Val Val
Pro1 5 10 17612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 176Leu Val Ala Ile Ala Pro Leu Ala Val Leu Ala
Pro1 5 10 17712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 177Ala Val Ala Leu Val Pro Val Ile Val Ala Ala
Pro1 5 10 17812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 178Ala Ile Ala Val Ala Ile Ala Pro Val Ala Leu
Pro1 5 10 17912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 179Ala Ile Ala Leu Ala Val Pro Val Leu Ala Leu
Pro1 5 10 18012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 180Leu Val Leu Ile Ala Ala Ala Pro Ile Ala Leu
Pro1 5 10 18112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 181Leu Val Ala Leu Ala Val Pro Ala Ala Val Leu
Pro1 5 10 18212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 182Ala Val Ala Leu Ala Val Pro Ala Leu Val Leu
Pro1 5 10 18312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 183Leu Val Val Leu Ala Ala Ala Pro Leu Ala Val
Pro1 5 10 18412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 184Leu Ile Val Leu Ala Ala Pro Ala Leu Ala Ala
Pro1 5 10 18512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 185Val Ile Val Leu Ala Ala Pro Ala Leu Ala Ala
Pro1 5 10 18612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 186Ala Val Val Leu Ala Val Pro Ala Leu Ala Val
Pro1 5 10 18712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 187Leu Ile Ile Val Ala Ala Ala Pro Ala Val Ala
Pro1 5 10 18812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 188Ile Val Ala Val Ile Val Ala Pro Ala Val Ala
Pro1 5 10 18912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 189Leu Val Ala Leu Ala Ala Pro Ile Ile Ala Val
Pro1 5 10 19012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 190Ile Ala Ala Val Leu Ala Ala Pro Ala Leu Val
Pro1 5 10 19112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 191Ile Ala Leu Leu Ala Ala Pro Ile Ile Ala Val
Pro1 5 10 19212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 192Ala Ala Leu Ala Leu Val Ala Pro Val Ile Val
Pro1 5 10 19312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 193Ile Ala Leu Val Ala Ala Pro Val Ala Leu Val
Pro1 5 10 19412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 194Ile Ile Val Ala Val Ala Pro Ala Ala Ile Val
Pro1 5 10 19512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 195Ala Val Ala Ala Ile Val Pro Val Ile Val Ala
Pro1 5 10 19612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 196Ala Val Leu Val Leu Val Ala Pro Ala Ala Ala
Pro1 5 10 19712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 197Val Val Ala Leu Leu Ala Pro Leu Ile Ala Ala
Pro1 5 10 19812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 198Ala Ala Val Val Ile Ala Pro Leu Leu Ala Val
Pro1 5 10 19912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 199Ile Ala Val Ala Val Ala Ala Pro Leu Leu Val
Pro1 5 10 20012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 200Leu Val Ala Ile Val Val Leu Pro Ala Val Ala
Pro1 5 10 20112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 201Ala Val Ala Ile Val Val Leu Pro Ala Val Ala
Pro1 5 10 20212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 202Ala Val Ile Leu Leu Ala Pro Leu Ile Ala Ala
Pro1 5 10 20312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 203Leu Val Ile Ala Leu Ala Ala Pro Val Ala Leu
Pro1 5 10 20412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 204Val Leu Ala Val Val Leu Pro Ala Val Ala Leu
Pro1 5 10 20512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 205Val Leu Ala Val Ala Ala Pro Ala Val Leu Leu
Pro1 5 10 20612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 206Ala Ala Val Val Leu Leu Pro Ile Ile Ala Ala
Pro1 5 10 20712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 207Ala Leu Leu Val Ile Ala Pro Ala Ile Ala Val
Pro1 5 10 20812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 208Ala Val Leu Val Ile Ala Val Pro Ala Ile Ala
Pro1 5 10 20912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 209Ala Leu Leu Val Val Ile Ala Pro Leu Ala Ala
Pro1 5 10 21012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 210Val Leu Val Ala Ala Ile Leu Pro Ala Ala Ile
Pro1 5 10 21112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 211Val Leu Val Ala Ala Val Leu Pro Ile Ala Ala
Pro1 5 10 21212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 212Val Leu Ala Ala Ala Val Leu Pro Leu Val Val
Pro1 5 10 21312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 213Ala Ile Ala Ile Val Val Pro Ala Val Ala Val
Pro1 5 10 21412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 214Val Ala Ile Ile Ala Val Pro Ala Val Val Ala
Pro1 5 10 21512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 215Ile Val Ala Leu Val Ala Pro Ala Ala Val Val
Pro1 5 10 21612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 216Ala Ala Ile Val Leu Leu Pro Ala Val Val Val
Pro1 5 10 21712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 217Ala Ala Leu Ile Val Val Pro Ala Val Ala Val
Pro1 5 10 21812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 218Ala Ile Ala Leu Val Val Pro Ala Val Ala Val
Pro1 5 10 21912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 219Leu Ala Ile Val Pro Ala Ala Ile Ala Ala Leu
Pro1 5 10 22012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 220Leu Val Ala Ile Ala Pro Ala Val Ala Val Leu
Pro1 5 10 22112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 221Val Leu Ala Val Ala Pro Ala Val Ala Val Leu
Pro1 5 10 22212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 222Ile Leu Ala Val Val Ala Ile Pro Ala Ala Ala
Pro1 5 10 22312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 223Ile Leu Val Ala Ala Ala Pro Ile Ala Ala Leu
Pro1 5 10 22412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 224Ile Leu Ala Val Ala Ala Ile Pro Ala Ala Leu
Pro1 5 10 22512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 225Val Ile Ala Ile Pro Ala Ile Leu Ala Ala Ala
Pro1 5 10 22612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 226Ala Ile Ile Ile Val Val Pro Ala Ile Ala Ala
Pro1 5 10 22712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 227Ala Ile Leu Ile Val Val Ala Pro Ile Ala Ala
Pro1 5 10 22812PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 228Ala Val Ile Val Pro Val Ala Ile Ile Ala Ala
Pro1 5 10 22912PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 229Ala Val Val Ile Ala Leu Pro Ala Val Val Ala
Pro1 5 10 23012PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 230Ala Leu Val Ala Val Ile Ala Pro Val Val Ala
Pro1 5 10 23112PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 231Ala Leu Val Ala Val Leu Pro Ala Val Ala Val
Pro1 5 10 23212PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 232Ala Leu Val Ala Pro Leu Leu Ala Val Ala Val
Pro1 5 10 23312PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 233Ala Val Leu Ala Val Val Ala Pro Val Val Ala
Pro1 5 10 23412PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 234Ala Val Ile Ala Val Ala Pro Leu Val Val Ala
Pro1 5 10 23512PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 235Ala Val Ile Ala Leu Ala Pro Val Val Val Ala
Pro1 5 10 23612PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 236Val Ala Ile Ala Leu Ala Pro Val Val Val Ala
Pro1 5 10 23712PRTArtificial SequenceAdvanced Macromolecule
Transduction Domain (aMTD) Sequences for Improvement of
Cell-Permeability 237Val Ala Leu Ala Leu Ala Pro Val Val Val Ala
Pro1
5 10 23812PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 238Val
Ala Ala Leu Leu Pro Ala Val Val Val Ala Pro1 5 10
23912PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 239Val
Ala Leu Ala Leu Pro Ala Val Val Val Ala Pro1 5 10
24012PRTArtificial SequenceAdvanced Macromolecule Transduction
Domain (aMTD) Sequences for Improvement of Cell-Permeability 240Val
Ala Leu Leu Ala Pro Ala Val Val Val Ala Pro1 5 10
24136DNAArtificial SequenceThe polynucleotide sequence that encodes
advanced Macromolecule Transduction Domain (aMTD) peptide for
Improvement of Cell-Permeability 241gcggcggcgc tggcgccggt
ggtgctggcg ctgccg 3624236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 242gcggcggcgg
tgccgctgct ggcggtggtg gtgccg 3624336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 243gcggcgctgc tggtgccggc ggcggtgctg gcgccg
3624436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 244gcgctggcgc tgctgccggt
ggcggcgctg gcgccg 3624536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 245gcggcggcgc
tgctgccggt ggcgctggtg gcgccg 3624636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 246gtggtggcgc tggcgccggc gctggcggcg ctgccg
3624736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 247ctgctggcgg cggtgccggc
ggtgctgctg gcgccg 3624836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 248gcggcggcgc
tggtgccggt ggtggcgctg ctgccg 3624936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 249gcggtggcgc tgctgccggc gctgctggcg gtgccg
3625036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 250gcggtggtgc tggtgccggt
gctggcggcg gcgccg 3625136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 251gtggtgctgg
tgctgccggc ggcggcggcg gtgccg 3625236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 252attgcgctgg cggcgccggc gctgattgtg gcgccg
3625336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 253attgtggcgg tggcgccggc
gctggtggcg ctgccg 3625436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 254gtggcggcgc
tgccggtggt ggcggtggtg gcgccg 3625536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 255ctgctggcgg cgccgctggt ggtggcggcg gtgccg
3625636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 256gcgctggcgg tgccggtggc
gctgctggtg gcgccg 3625736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 257gtggcggcgc
tgccggtgct gctggcggcg ctgccg 3625836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 258gtggcgctgc tggcgccggt ggcgctggcg gtgccg
3625936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 259gcggcgctgc tggtgccggc
gctggtggcg gtgccg 3626036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 260gcgattgtgg
cgctgccggt ggcggtgctg gcgccg 3626136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 261attgcgattg tggcgccggt ggtggcgctg gcgccg
3626236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 262gcggcgctgc tgccggcgct
ggcggcgctg ctgccg 3626336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 263gcggtggtgc
tggcgccggt ggcggcggtg ctgccg 3626436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 264ctggcggtgg cggcgccgct ggcgctggcg ctgccg
3626536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 265gcggcggtgg cggcgccgct
gctgctggcg ctgccg 3626636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 266ctgctggtgc
tgccggcggc ggcgctggcg gcgccg 3626736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 267ctggtggcgg tggcgccggt ggcggcggtg ctgccg
3626836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 268ctggcgctgg cgccggcggc
gctggcgctg ctgccg 3626936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 269gcgctgattg
cggcgccgat tctggcgctg gcgccg 3627036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 270gcggtggtgg cggcgccgct ggtgctggcg ctgccg
3627136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 271ctgctggcgc tggcgccggc
ggcgctgctg gcgccg 3627236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 272gcgattgtgg
cgctgccggc gctggcgctg gcgccg 3627336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 273gcggcgatta ttgtgccggc ggcgctgctg gcgccg
3627436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 274attgcggtgg cgctgccggc
gctgattgcg gcgccg 3627536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 275gcggtgattg
tgctgccggc gctggcggtg gcgccg 3627636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 276gcggtgctgg cggtgccggc ggtgctggtg gcgccg
3627736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 277gtgctggcga ttgtgccggc
ggtggcgctg gcgccg 3627836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 278ctgctggcgg
tggtgccggc ggtggcgctg gcgccg 3627936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 279gcggtgattg cgctgccggc gctgattgcg gcgccg
3628036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 280gcggtggtgg cgctgccggc
ggcgctgatt gtgccg 3628136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 281ctggcgctgg
tgctgccggc ggcgctggcg gcgccg 3628236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 282ctggcggcgg tgctgccggc gctgctggcg gcgccg
3628336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 283gcgctggcgg tgccggtggc
gctggcgatt gtgccg 3628436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 284gcgctgattg
cgccggtggt ggcgctggtg gcgccg 3628536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 285ctgctggcgg cgccggtggt gattgcgctg gcgccg
3628636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 286ctggcggcga ttgtgccggc
gattattgcg gtgccg 3628736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 287gcggcgctgg
tgctgccgct gattattgcg gcgccg 3628836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 288ctggcgctgg cggtgccggc gctggcggcg ctgccg
3628936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 289ctgattgcgg cgctgccggc
ggtggcggcg ctgccg 3629036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 290gcgctggcgc
tggtgccggc gattgcggcg ctgccg 3629136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 291gcggcgattc tggcgccgat tgtggcgctg gcgccg
3629236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 292gcgctgctga ttgcgccggc
ggcggtgatt gcgccg 3629336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 293gcgattctgg
cggtgccgat tgcggtggtg gcgccg 3629436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 294attctggcgg cggtgccgat tgcgctggcg gcgccg
3629536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 295gtggcggcgc tgctgccggc
ggcggcggtg ctgccg 3629636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 296gcggcggcgg
tggtgccggt gctgctggtg gcgccg 3629736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 297gcggcgctgc tggtgccggc gctggtggcg gcgccg
3629836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 298gcggcggtgc tgctgccggt
ggcgctggcg gcgccg 3629936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 299gcggcggcgc
tggcgccggt gctggcgctg gtgccg 3630036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 300ctggtgctgg tgccgctgct ggcggcggcg gcgccg
3630136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 301gcgctgattg cggtgccggc
gattattgtg gcgccg 3630236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 302gcgctggcgg
tgattccggc ggcggcgatt ctgccg 3630336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 303ctggcggcgg cgccggtggt gattgtgatt gcgccg
3630436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 304gtgctggcga ttgcgccgct
gctggcggcg gtgccg 3630536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 305gcgctgattg
tgctgccggc ggcggtggcg gtgccg 3630636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 306gtgctggcgg
tggcgccggc gctgattgtg gcgccg 3630736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 307gcggcgctgc tggcgccggc gctgattgtg gcgccg
3630836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 308gcgctgattg cgccggcggt
ggcgctgatt gtgccg 3630936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 309gcgattgtgc
tgctgccggc ggcggtggtg gcgccg 3631036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 310gtgattgcgg cgccggtgct ggcggtgctg gcgccg
3631136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 311ctggcgctgg cgccggcgct
ggcgctgctg gcgccg 3631236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 312gcgattattc
tggcgccgat tgcggcgatt gcgccg 3631336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 313attgcgctgg cggcgccgat tctgctggcg gcgccg
3631436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 314attgtggcgg tggcgctgcc
ggcgctggcg gtgccg 3631536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 315gtggtggcga
ttgtgctgcc ggcgctggcg gcgccg 3631636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 316attgtggcgg tggcgctgcc ggtggcgctg gcgccg
3631736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 317attgtggcgg tggcgctgcc
ggcggcgctg gtgccg 3631836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 318attgtggcgg
tggcgctgcc ggcggtggcg ctgccg 3631936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 319attgtggcgg tggcgctgcc ggcggtgctg gcgccg
3632036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 320gtgattgtgg cgctggcgcc
ggcggtgctg gcgccg 3632136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 321attgtggcgg
tggcgctgcc ggcgctggtg gcgccg 3632236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 322gcgctgctga ttgtggcgcc ggtggcggtg gcgccg
3632336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 323gcggtggtga ttgtggcgcc
ggcggtgatt gcgccg 3632436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 324gcggtgctgg
cggtggcgcc ggcgctgatt gtgccg 3632536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 325ctggtggcgg cggtggcgcc ggcgctgatt gtgccg
3632636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 326gcggtgattg tggtggcgcc
ggcgctgctg gcgccg 3632736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 327gtggtggcga
ttgtgctgcc ggcggtggcg gcgccg 3632836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 328gcggcggcgc tggtgattcc ggcgattctg gcgccg
3632936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 329gtgattgtgg cgctggcgcc
ggcgctgctg gcgccg 3633036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 330gtgattgtgg
cgattgcgcc ggcgctgctg gcgccg 3633136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 331attgtggcga ttgcggtgcc ggcgctggtg gcgccg
3633236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 332gcggcgctgg cggtgattcc
ggcggcgatt ctgccg 3633336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 333gcgctggcgg
cggtgattcc ggcggcgatt ctgccg 3633436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 334gcggcggcgc tggtgattcc ggcggcgatt ctgccg
3633536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 335ctggcggcgg cggtgattcc
ggcggcgatt ctgccg 3633636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 336ctggcggcgg
cggtgattcc ggtggcgatt ctgccg 3633736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 337gcggcgattc tggcggcgcc gctgattgcg gtgccg
3633836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 338gtggtggcga ttctggcgcc
gctgctggcg gcgccg 3633936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 339gcggtggtgg
tggcggcgcc ggtgctggcg ctgccg 3634036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 340gcggtggtgg cgattgcgcc ggtgctggcg ctgccg
3634136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 341gcgctggcgg cgctggtgcc
ggcggtgctg gtgccg 3634236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 342gcgctggcgg
cgctggtgcc ggtggcgctg gtgccg 3634336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 343ctggcggcgg cgctggtgcc ggtggcgctg gtgccg
3634436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 344gcgctggcgg cgctggtgcc
ggcgctggtg gtgccg 3634536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 345attgcggcgg
tgattgtgcc ggcggtggcg ctgccg 3634636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 346attgcggcgg tgctggtgcc ggcggtggcg ctgccg
3634736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 347gcggtggcga ttctggtgcc
gctgctggcg gcgccg 3634836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 348gcggtggtga
ttctggtgcc gctggcggcg gcgccg 3634936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 349attgcggcgg tgattgtgcc ggtggcggcg ctgccg
3635036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 350gcgattgcga ttgcgattgt
gccggtggcg ctgccg 3635136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 351attctggcgg
tggcggcgat tccggtggcg gtgccg 3635236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 352attctggcgg cggcgattat tccggcggcg ctgccg
3635336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 353ctggcggtgg tgctggcggc
gccggcgatt gtgccg 3635436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 354gcgattctgg
cggcgattgt gccgctggcg gtgccg 3635536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 355gtgattgtgg cgctggcggt gccggcgctg gcgccg
3635636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 356gcgattgtgg cgctggcggt
gccggtgctg gcgccg 3635736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 357gcggcgatta
ttattgtgct gccggcggcg ctgccg 3635836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 358ctgattgtgg cgctggcggt gccggcgctg gcgccg
3635936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 359gcgattatta ttgtgattgc
gccggcggcg gcgccg 3636036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 360ctggcggcgc
tgattgtggt gccggcggtg gcgccg 3636136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 361gcgctgctgg tgattgcggt gccggcggtg gcgccg
3636236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 362gcggtggcgc tgattgtggt
gccggcgctg gcgccg 3636336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 363gcgctggcga
ttgtggtggc gccggtggcg gtgccg 3636436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 364ctgctggcgc tgattattgc gccggcggcg gcgccg
3636536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 365gcgctggcgc tgattattgt
gccggcggtg gcgccg 3636636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 366ctgctggcgg
cgctgattgc gccggcggcg ctgccg 3636736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 367attgtggcgc tgattgtggc gccggcggcg gtgccg
3636836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 368gtggtgctgg tgctggcggc
gccggcggcg gtgccg 3636936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 369gcggcggtgg
cgattgtgct gccggcggtg gtgccg 3637036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 370gcgctgattg cggcgattgt gccggcgctg gtgccg
3637136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 371gcgctggcgg tgattgtggt
gccggcgctg gcgccg 3637236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 372gtggcgattg
cgctgattgt gccggcgctg gcgccg 3637336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 373gtggcgattg tgctggtggc gccggcggtg gcgccg
3637436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 374gtggcggtgg cgctgattgt
gccggcgctg gcgccg 3637536DNAArtificial SequenceThe polynucleotide
sequence
that encodes advanced Macromolecule Transduction Domain (aMTD)
peptide for Improvement of Cell-Permeability 375gcggtgattc
tggcgctggc gccgattgtg gcgccg 3637636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 376gcgctgattg tggcgattgc gccggcgctg gtgccg
3637736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 377gcggcgattc tgattgcggt
gccgattgcg gcgccg 3637836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 378gtgattgtgg
cgctggcggc gccggtgctg gcgccg 3637936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 379gtgctggtgg cgctggcggc gccggtgatt gcgccg
3638036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 380gtggcgctga ttgcggtggc
gccggcggtg gtgccg 3638136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 381gtgattgcgg
cggtgctggc gccggtggcg gtgccg 3638236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 382gcgctgattg tgctggcggc gccggtggcg gtgccg
3638336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 383gtggcggcgg cgattgcgct
gccggcgatt gtgccg 3638436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 384attctggcgg
cggcggcggc gccgctgatt gtgccg 3638536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 385ctggcgctgg tgctggcggc gccggcgatt gtgccg
3638636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 386gcgctggcgg tggtggcgct
gccggcgatt gtgccg 3638736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 387gcggcgattc
tggcgccgat tgtggcggcg ctgccg 3638836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 388attctgattg cgattgcgat tccggcggcg gcgccg
3638936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 389ctggcgattg tgctggcggc
gccggtggcg gtgccg 3639036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 390gcggcgattg
cgattattgc gccggcgatt gtgccg 3639136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 391ctggcggtgg cgattgtggc gccggcgctg gtgccg
3639236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 392ctggcgattg tgctggcggc
gccggcggtg ctgccg 3639336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 393gcggcgattg
tgctggcgct gccggcggtg ctgccg 3639436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 394gcgctgctgg tggcggtgct gccggcggcg ctgccg
3639536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 395gcggcgctgg tggcggtgct
gccggtggcg ctgccg 3639636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 396gcgattctgg
cggtggcgct gccgctgctg gcgccg 3639736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 397attgtggcgg tggcgctggt gccggcgctg gcgccg
3639836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 398attgtggcgg tggcgctgct
gccggcgctg gcgccg 3639936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 399attgtggcgg
tggcgctgct gccggcggtg gcgccg 3640036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 400attgtggcgc tggcggtgct gccggcggtg gcgccg
3640136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 401gtggcggtgc tggcggtgct
gccggcgctg gcgccg 3640236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 402attgcggtgc
tggcggtggc gccggcggtg ctgccg 3640336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 403ctggcggtgg cgattattgc gccggcggtg gcgccg
3640436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 404gtggcgctgg cgattgcgct
gccggcggtg ctgccg 3640536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 405gcgattgcga
ttgcgctggt gccggtggcg ctgccg 3640636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 406gcggcggtgg tgattgtggc gccggtggcg ctgccg
3640736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 407gcggcgattc tggcgattgt
ggcgccgctg gcgccg 3640836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 408gtggcgctgc
tggcgattgc gccggcgctg gcgccg 3640936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 409gtggcggtgc tgattgcggt gccggcgctg gcgccg
3641036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 410gcggtggcgc tggcggtgct
gccggcggtg gtgccg 3641136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 411gcggtggcgc
tggcggtggt gccggcggtg ctgccg 3641236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 412attgtggtga ttgcggtggc gccggcggtg gcgccg
3641336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 413attgtggtgg cggcggtggt
gccggcgctg gcgccg 3641436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 414attgtggcgc
tggtgccggc ggtggcgatt gcgccg 3641536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 415gtggcggcgc tgccggcggt ggcgctggtg gtgccg
3641636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 416ctggtggcga ttgcgccgct
ggcggtgctg gcgccg 3641736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 417gcggtggcgc
tggtgccggt gattgtggcg gcgccg 3641836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 418gcgattgcgg tggcgattgc gccggtggcg ctgccg
3641936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 419gcgattgcgc tggcggtgcc
ggtgctggcg ctgccg 3642036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 420ctggtgctga
ttgcggcggc gccgattgcg ctgccg 3642136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 421ctggtggcgc tggcggtgcc ggcggcggtg ctgccg
3642236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 422gcggtggcgc tggcggtgcc
ggcgctggtg ctgccg 3642336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 423ctggtggtgc
tggcggcggc gccgctggcg gtgccg 3642436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 424ctgattgtgc tggcggcgcc ggcgctggcg gcgccg
3642536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 425gtgattgtgc tggcggcgcc
ggcgctggcg gcgccg 3642636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 426gcggtggtgc
tggcggtgcc ggcgctggcg gtgccg 3642736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 427ctgattattg tggcggcggc gccggcggtg gcgccg
3642836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 428attgtggcgg tgattgtggc
gccggcggtg gcgccg 3642936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 429ctggtggcgc
tggcggcgcc gattattgcg gtgccg 3643036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 430attgcggcgg tgctggcggc gccggcgctg gtgccg
3643136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 431attgcgctgc tggcggcgcc
gattattgcg gtgccg 3643236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 432gcggcgctgg
cgctggtggc gccggtgatt gtgccg 3643336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 433attgcgctgg tggcggcgcc ggtggcgctg gtgccg
3643436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 434attattgtgg cggtggcgcc
ggcggcgatt gtgccg 3643536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 435gcggtggcgg
cgattgtgcc ggtgattgtg gcgccg 3643636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 436gcggtgctgg tgctggtggc gccggcggcg gcgccg
3643736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 437gtggtggcgc tgctggcgcc
gctgattgcg gcgccg 3643836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 438gcggcggtgg
tgattgcgcc gctgctggcg gtgccg 3643936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 439attgcggtgg cggtggcggc gccgctgctg gtgccg
3644036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 440ctggtggcga ttgtggtgct
gccggcggtg gcgccg 3644136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 441gcggtggcga
ttgtggtgct gccggcggtg gcgccg 3644236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 442gcggtgattc tgctggcgcc gctgattgcg gcgccg
3644336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of
Cell-Permeability 443ctggtgattg cgctggcggc gccggtggcg ctgccg
3644436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 444gtgctggcgg tggtgctgcc
ggcggtggcg ctgccg 3644536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 445gtgctggcgg
tggcggcgcc ggcggtgctg ctgccg 3644636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 446gcggcggtgg tgctgctgcc gattattgcg gcgccg
3644736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 447gcgctgctgg tgattgcgcc
ggcgattgcg gtgccg 3644836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 448gcggtgctgg
tgattgcggt gccggcgatt gcgccg 3644936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 449gcgctgctgg tggtgattgc gccgctggcg gcgccg
3645036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 450gtgctggtgg cggcgattct
gccggcggcg attccg 3645136DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 451gtgctggtgg
cggcggtgct gccgattgcg gcgccg 3645236DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 452gtgctggcgg cggcggtgct gccgctggtg gtgccg
3645336DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 453gcgattgcga ttgtggtgcc
ggcggtggcg gtgccg 3645436DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 454gtggcgatta
ttgcggtgcc ggcggtggtg gcgccg 3645536DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 455attgtggcgc tggtggcgcc ggcggcggtg gtgccg
3645636DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 456gcggcgattg tgctgctgcc
ggcggtggtg gtgccg 3645736DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 457gcggcgctga
ttgtggtgcc ggcggtggcg gtgccg 3645836DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 458gcgattgcgc tggtggtgcc ggcggtggcg gtgccg
3645936DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 459ctggcgattg tgccggcggc
gattgcggcg ctgccg 3646036DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 460ctggtggcga
ttgcgccggc ggtggcggtg ctgccg 3646136DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 461gtgctggcgg tggcgccggc ggtggcggtg ctgccg
3646236DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 462attctggcgg tggtggcgat
tccggcggcg gcgccg 3646336DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 463attctggtgg
cggcggcgcc gattgcggcg ctgccg 3646436DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 464attctggcgg tggcggcgat tccggcggcg ctgccg
3646536DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 465gtgattgcga ttccggcgat
tctggcggcg gcgccg 3646636DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 466gcgattatta
ttgtggtgcc ggcgattgcg gcgccg 3646736DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 467gcgattctga ttgtggtggc gccgattgcg gcgccg
3646836DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 468gcggtgattg tgccggtggc
gattattgcg gcgccg 3646936DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 469gcggtggtga
ttgcgctgcc ggcggtggtg gcgccg 3647036DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 470gcgctggtgg cggtgattgc gccggtggtg gcgccg
3647136DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 471gcgctggtgg cggtgctgcc
ggcggtggcg gtgccg 3647236DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 472gcgctggtgg
cgccgctgct ggcggtggcg gtgccg 3647336DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 473gcggtgctgg cggtggtggc gccggtggtg gcgccg
3647436DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 474gcggtgattg cggtggcgcc
gctggtggtg gcgccg 3647536DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 475gcggtgattg
cgctggcgcc ggtggtggtg gcgccg 3647636DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 476gtggcgattg cgctggcgcc ggtggtggtg gcgccg
3647736DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 477gtggcgctgg cgctggcgcc
ggtggtggtg gcgccg 3647836DNAArtificial SequenceThe polynucleotide
sequence that encodes advanced Macromolecule Transduction Domain
(aMTD) peptide for Improvement of Cell-Permeability 478gtggcggcgc
tgctgccggc ggtggtggtg gcgccg 3647936DNAArtificial SequenceThe
polynucleotide sequence that encodes advanced Macromolecule
Transduction Domain (aMTD) peptide for Improvement of
Cell-Permeability 479gtggcgctgg cgctgccggc ggtggtggtg gcgccg
3648036DNAArtificial SequenceThe polynucleotide sequence that
encodes advanced Macromolecule Transduction Domain (aMTD) peptide
for Improvement of Cell-Permeability 480gtggcgctgc tggcgccggc
ggtggtggtg gcgccg 3648157DNAArtificial SequencecDNA Sequence of
Histidine Tag 481atgggcagca gccatcatca tcatcatcac agcagcggcc
tggtgccgcg cggcagc 5748219PRTArtificial SequenceAmino Acid Sequence
of Histidine Tag 482Met Gly Ser Ser His His His His His His Ser Ser
Gly Leu Val Pro 1 5 10 15 Arg Gly Ser 48336DNAArtificial
SequencecDNA Sequences of aMTDs 483gcgctggcgg tgccggtggc gctggcgatt
gtgccg 3648412PRTArtificial SequenceAmino Acid Sequences of aMTDs
484Ala Leu Ala Val Pro Val Ala Leu Ala Ile Val Pro 1 5 10
485675DNAArtificial SequencecDNA Sequence of human SOCS3
485atggtcaccc acagcaagtt tcccgccgcc gggatgagcc gccccctgga
caccagcctg 60cgcctcaaga ccttcagctc caagagcgag taccagctgg tggtgaacgc
agtgcgcaag 120ctgcaggaga gcggcttcta ctggagcgca gtgaccggcg
gcgaggcgaa cctgctgctc 180agtgccgagc ccgccggcac ctttctgatc
cgcgacagct cggaccagcg ccacttcttc 240acgctcagcg tcaagaccca
gtctgggacc aagaacctgc gcatccagtg tgaggggggc 300agcttctctc
tgcagagcga tccccggagc acgcagcccg tgccccgctt cgactgcgtg
360ctcaagctgg tgcaccacta catgccgccc cctggagccc cctccttccc
ctcgccacct 420actgaaccct cctccgaggt gcccgagcag ccgtctgccc
agccactccc tgggagtccc 480cccagaagag cctattacat ctactccggg
ggcgagaaga tccccctggt gttgagccgg 540cccctctcct ccaacgtggc
cactcttcag catctctgtc ggaagaccgt caacggccac 600ctggactcct
atgagaaagt cacccagctg ccggggccca ttcgggagtt cctggaccag
660tacgatgccc cgctt 675486225PRTArtificial SequenceAmino Acid
Sequence of human SOCS3 486Met Val Thr His Ser Lys Phe Pro Ala Ala
Gly Met Ser Arg Pro Leu 1 5 10 15 Asp Thr Ser Leu Arg Leu Lys Thr
Phe Ser Ser Lys Ser Glu Tyr Gln 20 25 30 Leu Val Val Asn Ala Val
Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 35 40 45 Ser Ala Val Thr
Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 50 55 60 Ala Gly
Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 65 70 75 80
Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 85
90 95 Cys Gly Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr
Gln 100 105 110 Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His
His Tyr Met 115 120 125 Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro
Pro Thr Glu Pro Ser 130 135 140 Ser Glu Val Pro Glu Gln Pro Ser Ala
Gln Pro Leu Pro Gly Ser Pro 145 150 155 160 Pro Arg Arg Ala Tyr Tyr
Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 165 170 175 Val Leu Ser Arg
Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 180 185 190 Cys Arg
Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 195 200 205
Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 210
215 220 Leu 225 487552DNAArtificial SequencecDNA Sequences of SDA
487atggcaaata ttaccgtttt ctataacgaa gacttccagg gtaagcaggt
cgatctgccg 60cctggcaact atacccgcgc ccagttggcg gcgctgggca tcgagaataa
taccatcagc 120tcggtgaagg tgccgcctgg cgtgaaggct atcctgtacc
agaacgatgg tttcgccggc 180gaccagatcg aagtggtggc caatgccgag
gagttgggcc cgctgaataa taacgtctcc 240agcatccgcg tcatctccgt
gcccgtgcag ccgcgcatgg caaatattac cgttttctat 300aacgaagact
tccagggtaa gcaggtcgat ctgccgcctg gcaactatac ccgcgcccag
360ttggcggcgc tgggcatcga gaataatacc atcagctcgg tgaaggtgcc
gcctggcgtg 420aaggctatcc tctaccagaa cgatggtttc gccggcgacc
agatcgaagt ggtggccaat 480gccgaggagc tgggtccgct gaataataac
gtctccagca tccgcgtcat ctccgtgccg 540gtgcagccga gg
552488184PRTArtificial SequenceAmino Acid Sequences of SDA 488Met
Ala Asn Ile Thr Val Phe Tyr Asn Glu Asp Phe Gln Gly Lys Gln 1 5 10
15 Val Asp Leu Pro Pro Gly Asn Tyr Thr Arg Ala Gln Leu Ala Ala Leu
20 25 30 Gly Ile Glu Asn Asn Thr Ile Ser Ser Val Lys Val Pro Pro
Gly Val 35 40 45 Lys Ala Ile Leu Tyr Gln Asn Asp Gly Phe Ala Gly
Asp Gln Ile Glu 50 55 60 Val Val Ala Asn Ala Glu Glu Leu Gly Pro
Leu Asn Asn Asn Val Ser 65 70 75 80 Ser Ile Arg Val Ile Ser Val Pro
Val Gln Pro Arg Met Ala Asn Ile 85 90 95 Thr Val Phe Tyr Asn Glu
Asp Phe Gln Gly Lys Gln Val Asp Leu Pro 100 105 110 Pro Gly Asn Tyr
Thr Arg Ala Gln Leu Ala Ala Leu Gly Ile Glu Asn 115 120 125 Asn Thr
Ile Ser Ser Val Lys Val Pro Pro Gly Val Lys Ala Ile Leu 130 135 140
Tyr Gln Asn Asp Gly Phe Ala Gly Asp Gln Ile Glu Val Val Ala Asn 145
150 155 160 Ala Glu Glu Leu Gly Pro Leu Asn Asn Asn Val Ser Ser Ile
Arg Val 165 170 175 Ile Ser Val Pro Val Gln Pro Arg 180
489297DNAArtificial SequencecDNA Sequences of SDB 489atggcagaac
aaagcgacaa ggatgtgaag tactacactc tggaggagat tcagaagcac 60aaagacagca
agagcacctg ggtgatccta catcataagg tgtacgatct gaccaagttt
120ctcgaagagc atcctggtgg ggaagaagtc ctgggcgagc aagctggggg
tgatgctact 180gagaactttg aggacgtcgg gcactctacg gatgcacgag
aactgtccaa aacatacatc 240atcggggagc tccatccaga tgacagatca
aagatagcca agccttcgga aaccctt 29745099PRTArtificial SequenceAmino
Acid Sequences of SDB 450Met Ala Glu Gln Ser Asp Lys Asp Val Lys
Tyr Tyr Thr Leu Glu Glu 1 5 10 15 Ile Gln Lys His Lys Asp Ser Lys
Ser Thr Trp Val Ile Leu His His 20 25 30 Lys Val Tyr Asp Leu Thr
Lys Phe Leu Glu Glu His Pro Gly Gly Glu 35 40 45 Glu Val Leu Gly
Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 50 55 60 Asp Val
Gly His Ser Thr Asp Ala Arg Glu Leu Ser Lys Thr Tyr Ile 65 70 75 80
Ile Gly Glu Leu His Pro Asp Asp Arg Ser Lys Ile Ala Lys Pro Ser 85
90 95 Glu Thr Leu
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