U.S. patent application number 14/925573 was filed with the patent office on 2016-02-25 for herbal skin care composition.
The applicant listed for this patent is Nefeli Corp.. Invention is credited to Ping Zhang.
Application Number | 20160051463 14/925573 |
Document ID | / |
Family ID | 47830040 |
Filed Date | 2016-02-25 |
United States Patent
Application |
20160051463 |
Kind Code |
A1 |
Zhang; Ping |
February 25, 2016 |
HERBAL SKIN CARE COMPOSITION
Abstract
Described herein is a method of treating aging skin in a
subject, the method comprising applying a topical skin care
composition to a surface of the skin of the subject in need
thereof, the composition containing a whole plant extract solution
of Dendrobium Huoshanense
Inventors: |
Zhang; Ping; (Port
Washington, NY) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
Nefeli Corp. |
Port Washington |
NY |
US |
|
|
Family ID: |
47830040 |
Appl. No.: |
14/925573 |
Filed: |
October 28, 2015 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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13618187 |
Sep 14, 2012 |
9192643 |
|
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14925573 |
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61534818 |
Sep 14, 2011 |
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Current U.S.
Class: |
424/725 |
Current CPC
Class: |
A61K 8/9794 20170801;
A61K 36/898 20130101; A61K 36/8984 20130101; A61Q 19/007 20130101;
A61Q 19/02 20130101; A61Q 19/08 20130101 |
International
Class: |
A61K 8/97 20060101
A61K008/97; A61Q 19/00 20060101 A61Q019/00; A61Q 19/02 20060101
A61Q019/02; A61Q 19/08 20060101 A61Q019/08 |
Claims
1. A method of treating aging skin in a subject, the method
comprising applying a topical skin care composition to a surface of
the skin of the subject in need thereof, the composition containing
a whole plant extract solution of Dendrobium Huoshanense, wherein
the extract solution is obtained by extracting a dried whole
Dendrobium Huoshanense plant with a solvent, the ratio of the dried
whole Dendrobium Huoshanense plant to the extract solution being
0.1:100 to 7:100 by weight.
2. The method of claim 1, wherein the extract solution is
unfermented.
3. The method of claim 1, wherein the ratio of the dried whole
Dendrobium Huoshanense plant to the extract solution is 1:100 to
1:20 by weight.
4. The method of claim 1, wherein the composition contains the
extract solution in the range of 0.01%-25% by weight.
5. The method of claim 1, wherein the dried whole Dendrobium
Huoshanense plant is extracted with water as the only solvent.
6. The method of claim 1, wherein the surface of the skin has
wrinkles, blemishes, dryness, roughness, dullness, brown spots,
dark spots, age spots, or sagging.
7. The method of claim 1, wherein the composition further contains
a topical carrier.
8. The method of claim 7, wherein the composition is a cream,
moisturizer, lotion, aqueous gel, non-aqueous gel, serum, mask,
ointment, foam, or spray.
9. The method of claim 8, wherein the ratio of the dried whole
Dendrobium Huoshanense plant to the extract solution is 1:100 to
1:20 by weight.
10. The method of claim 8, wherein the composition contains the
extract solution in the range of 0.01%-25% by weight.
11. The method of claim 8, wherein the surface of the skin has
wrinkles, blemishes, dryness, roughness, dullness, brown spots,
dark spots, age spots, or sagging.
12. The method of claim 1, wherein the composition further includes
an ingredient selected from the group consisting of a pigment,
fragrance, preservative, protective, adsorbent, demulcent,
emollient, buffering agent, skin-penetration agent, surfactant,
sunscreen, and oil.
13. The method of claim 1, wherein the extract solution is obtained
by a process including: (1) soaking a dried whole Dendrobium
Huoshanense plant in water for at least twelve hours at room
temperature to obtain a mixture; (2) boiling and then cooling the
mixture to 115-120.degree. F. to obtain a cooled mixture; (3)
blending, grinding, crushing, or pulverizing the cooled mixture to
obtain a blended mixture; (4) simmering and then cooling the
blended mixture to room temperature to obtain a cooled blended
mixture; (5) repeating steps (3) and (4); (6) removing solids from
the cooled blended mixture to obtain an extract solution; and (7)
concentrating the extract solution.
Description
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation of U.S. patent
application Ser. No. 13/618,187, filed on Sep. 14, 2012, which
claims priority to U.S. Provisional Application No. 61/534,818,
filed on Sep. 14, 2011. The contents of both prior applications are
hereby incorporated by reference herein in their entirety.
BACKGROUND
[0002] Aging of skin results from a combination of intrinsic
factors, e.g., genetic factors, to and extrinsic factors, e.g.,
environmental factors such as sun damage and smoking. Aging of skin
takes place at the microscopic and biochemical level, and manifests
outwardly as various signs, e.g., wrinkles, dryness, roughness,
dullness, brown/dark/age spots, and sagging of the skin.
[0003] Although a number anti-aging skin care products are
commercially available, synthetic ingredients in many of these
products may be harsh, irritating or even harmful to the skin or
the user over time. Consumers are seeking skin care products that
are not only natural but also effective with little or no side
effects.
SUMMARY
[0004] This invention is based on the unexpected discovery that an
extract solution of Dendrobium Huoshanense can reduce signs of skin
aging when applied topically.
[0005] Accordingly, described herein is a topical skin care
composition containing an extract solution of Dendrobium
Huoshanense and one or more topical carriers. The extract solution
can be obtained by extracting dried Dendrobium Huoshanense with a
solvent, the ratio of the dried Dendrobium Huoshanense to the
extract solution being 0.1:100 to 7:100 by weight.
[0006] In another aspect, also contemplated herein is a method of
treating aging of skin in a subject using the above-described
topical skin care composition. For example, the composition can be
used to treat, reduce, or improve one or more signs of aging, e.g.
wrinkles, dryness, roughness, dullness, blotchiness, brown/dark/age
spots, blemishes, and/or skin sagging.
[0007] The details of one or more embodiments of the invention are
set forth in the accompanying drawing and the description below.
Other features, objects, and advantages of the invention will be
apparent from the description and drawing, and from the claims.
DETAILED DESCRIPTION
[0008] Described herein is a topical skin care composition that
includes an extract solution of Dendrobium Huoshanense and one or
more topical carriers. This composition can be used to treat aging
of the skin.
[0009] Dendrobium Huoshanense is one species of Dendrobium.
Dendrobium is a large genus of orchids that originate mainly in
tropical and subtropical Asia, Australia, and the Pacific islands.
There are around 1000 different species globally. Among these 1000
species, 76 species can be found in China, most of them being
naturally located in southwestern and southern China and Taiwan.
Dendrobium Huoshanense, one of the 76 species, grows primarily on
ancient tree branches or rock cliffs at very high altitudes in the
Dabie Mountain area of Huoshan, Anhui province.
[0010] Dendrobium Huoshanense is an herbal used in Traditional
Chinese Medicine. Extracts of Dendrobium Huoshanense are
traditionally administered orally to patients for various purposes,
e.g., release or alleviate thirst, awaking the spleen (which, in
Traditional Chinese Medicine, means to strengthen the digestive
system), release summer heat from the body, increase the body's
energy, preserve health, and promote longevity. It has also been
used orally to fight fatigue, nourish the visceral system, relieve
dryness, calm wheezing, brighten eyes, and restores the voice.
Recently, Dendrobium Huoshanense has been demonstrated to have
antitumor and blood sugar lowering effects.
[0011] An extract solution of Dendrobium Huoshanense, as that term
is used herein, refers to an extract solution obtained by
extracting Dendrobium Huoshanense plant material with a solvent,
the ratio of the plant material to the final extract solution being
0.1:100 to 7:100 by weight, e.g., 1:20 or 1:100. For example, the
extract solution can be prepared by using 0.1 g to 7 g of dried
Dendrobium Huoshanense to create 100 g of herbal extract solution.
A skilled practitioner would readily appreciate that the solvent
used for extraction should be suitable for application to the skin
of a subject, e.g., a human patient. The Dendrobium Huoshanense
plant material used can be in the form of whole dried plant,
crushed herb, or powdered herb.
[0012] The extract solution of Dendrobium Huoshanense can be
obtained by various conventional methods. Such methods include, but
are not limited to, soaking, boiling, extracting by an soxhlet
extractor, pressure cooking, or infusing Dendrobium Huoshanense
plant material in various media. The media include, but are not
limited to, water, alcohols (e.g. ethanol and isopropanol), other
organic solvents (e.g. acetone, hexane, diethyl ether, and
petroleum ether), oil, and combinations of such extraction media.
After extraction, the extract solution can be separated from the
solid by sieving, filtering, pressing or another suitable method.
The extract solution of Dendrobium Huoshanense thus prepared can be
used as is without further treatment or modification, e.g.,
fermentation. Alternatively, the extract solution can be further
treated, for example, by adding rice and yeast to ferment the
solution. The fermented mixture can then be filtered to remove the
solid material.
[0013] Described in Example 1 below is an exemplary method of
extraction using 1 g of dried Dendrobium huosanese. It should be
noted that this method can be altered in a wide variety of ways,
such as increasing or decreasing the soaking and/or boiling times,
changing the solvent, increasing or decreasing the number of
boiling steps, substituting other extraction techniques for boiling
and/or soaking, eliminating or switching the order of steps, and
substituting blending with other methods of grinding, crushing,
pulverizing or mixing an herbal/solvent mixture.
[0014] The topical skin care composition described herein can
contain about 0.01% -25% by weight of an extract solution of
Dendrobium Huoshanense, including 0.05%, 0.1%, 0.5%, 1%, 2%, 3%,
4%, 5%, 6%, 7%, 8%, 9%, 10%, 12% 15%, 20%, and 25%. For example,
the composition can contain 1%-25% of the extract solution.
[0015] In addition, the topical skin care composition includes one
or more excipients, vehicles, or media known in the art for topical
administration. As used herein, the term "topical carrier" or
"topical excipient" refers to an ingredient that is not suitable
for oral administration. A topical carrier can be used, for
example, to formulate the composition in a particular form (e.g.,
cream), or to enhance the feel, color, scent, absorbability, or
spreadibility of the composition. For example, the skin care
composition can include ingredients that are found in a cosmetic
formulation, such as pigments, fragrances, preservatives,
protectives, adsorbents, demulcents, emollients, buffering agents,
skin-penetration agents, and surfactants. In some embodiments, the
topical skin care composition also contains one or more other skin
care ingredients, e.g., sunscreens, antioxidants, vitamins, oils,
fermented rice and/or other herbals. The types and amounts of the
above-discussed optional ingredients can be determined by one of
ordinary skill in the art based upon general knowledge in the skin
care formulation art.
[0016] The topical skin care composition described above can be
formulated as a cream, moisturizer, lotion, aqueous gel,
non-aqueous gel, serum, mask, ointment, liquid, foam, spray, or any
other form suitable for topical application.
[0017] Data described below show that an extract solution of
Dendrobium Huoshanense effectively reduced or improved various
signs of skin aging. Accordingly, the above-described topical skin
care composition is useful for treating aging of skin. For example,
is the composition can be used to prevent, reduce, slow, alleviate,
correct, or improve one or more signs of aging, e.g. wrinkles,
dryness, roughness, dullness, blotchiness, brown/dark/age spots,
blemishes, and skin sagging.
[0018] The skin care composition can be applied to various areas of
the skin, e.g., face, neck, decolletage, hands, and feet, as
needed. In some embodiments, the composition is zo applied once or
twice daily. A skilled practitioner would readily recognize that
the frequency of use depends on the needs of the user, the
condition of the user's skin, and other factors known in the skin
care arts.
[0019] The specific examples below are to be construed as merely
illustrative, and not limitative of the remainder of the disclosure
in any way whatsoever. Without further elaboration, it is believed
that one skilled in the art can, based on the description herein,
utilize the present invention to its fullest extent. All
publications cited herein are herein incorporated by reference in
their entirety.
Example 1: Preparation of an Dendrobium Huoshanense Extract
Solution
[0020] One gram of dried Dendrobium Huoshanense herbal was placed
in 750 ml of water. The herbal was soaked for a minimum of 12 hours
at room temperature. The mixture was then brought to a boil and
then allowed to cool to 115-120.degree. F. The entire mixture was
then blended in a blender or similar apparatus. The blended mixture
was then boiled for about 30 minutes at low heat, i.e., simmered,
and then cooled to room temperature. The mixture was blended again
in a blender or similar apparatus. The above series of simmering,
cooling, and blending steps was repeated two more times. The liquid
was then separated from the solid in the blended mixture by
sieving, filtering, pressing, or another suitable method. The
liquid was then evaporated by boiling to reduce its volume to about
100 ml (about 100 g by weight). This resulting liquid, i.e., a
Dendrobium Huoshanense extract solution, can be used as is to make
a skin care formulation.
Example 2: Effects of an Dendrobium Huoshanense Extract Solution on
Signs of Skin Aging
[0021] Three patients were treated topically with a Dendrobium
Huoshanense extract is solution prepared from dried Dendrobium
Huoshanense using the procedure described in Example 1 above. The
ratio of the dried Dendrobium Huoshanense to the final extract
solution was 1:20 by weight.
(A) Patient A
[0022] Patient A was a 46-year-old female complaining of having dry
skin, and fine lines and wrinkles on her face, especially around
the eye and mouth area. Patient A also complained about unevenness
and dullness of complexion.
[0023] Patient A's initial clinical observations included: (1)
blotchiness, redness, and irritation around the nose area and
across both checks, as well as chin area; (2) dry skin all over the
face with wrinkles around the eye and lip area (smoker lines); (3)
dark spots all over the face, especially on the left cheek; (4)
uneven skin tone in chin and cheek areas; and (5) rough skin and
sagging in the cheek area.
[0024] Patient A was prescribed the 1:20 extract solution of
Dendrobium Huoshanense. She was instructed to apply the extract
twice daily, i.e., 10 drops in the morning and 10 drops in the
evening, on clean face. Patient A followed the regiment for six
weeks.
[0025] The results of the six-week clinical trial are summarized
below.
[0026] The frown lines on Patient A's forehead have decreased in
length and depth. The nasal folds and smile lines along the left
side of the mouth have decreased in length and depth.
[0027] There was a decrease in sagging of skin. Overall skin tone
was improved. There was also a significant reduction in irritation
and redness.
[0028] The upper eyelid of her left eye showed lifting, less
sagging, and significantly diminished appearance of fine lines.
[0029] There was less roughness and smoother skin under the eyes,
particularly under the right eye.
[0030] There was an overall improvement in skin tone, dullness,
blotchiness, and appearance of dark spots.
[0031] Data were also obtained from Image Pro I, an imaging device
and skin care analysis system. RBG spots and UV spots were measured
for each captured image. Results were from comparisons of images
captured on the start and end dates of the six is week trial. The
data showed improvements in both RBG spots and UV spots.
[0032] Patient A indicated significant improvements in the
following areas: wrinkles around the eyes and mouth, sagging skin
in chin and neck area, age spots, discoloration, dark spots, dull
skin, suppleness, and skin texture.
[0033] Patient A's comments included: "skin feels smoother and more
regular in texture," "dark spots going away--especially (on) left
cheek," "skin feels more supple and fewer wrinkles and
sagging,"
[0034] (2) Patient B
[0035] Patient B was a 58-year-old female with complaints of
overall sagging of face, deep wrinkles, blotchiness and redness of
skin, dry skin with roughness especially in the chin area, sagging
of the cheek, chin and eyelid area, and a sallow and dull
complexion.
[0036] Patient B's initial clinical observations included: (1)
rough and dry skin; (2) redness, blotchiness and irritation,
especially around nose area and on both cheek areas; (3) sagging of
face, including eyelids, cheek, and chin area; (4) deep wrinkles in
forehead area, eyebrow area, outside of eye (i.e., crows feet),
upper lip area (i.e., smoker line), and nasal labial folds.
[0037] Patient B was prescribed the 1:20 extract solution of
Dendrobium Huoshanense. She was instructed to apply the extract
twice daily, i.e., 10 drops in the morning and 10 drops in the
evening, on clean face. Patient B followed the regiment for eight
weeks.
[0038] The results of the eight-week clinical trial are summarized
below.
[0039] The frown lines on Patient B's forehead have decreased in
length and depth.
[0040] The ridges on bridge of nose were less significant in depth,
and there was a decreased appearance of fine lines.
[0041] Patient B's upper eyelids showed lifting, less sagging, and
a significant reduction of fine lines.
[0042] The crows feet along her right eye have diminished
significantly. The fine lines have significantly reduced in depth
and length.
[0043] The nasal folds and smile lines along the right side of
Patient B's mouth have decreased in length and depth. The skin tone
has improved, and there was visibly reduced irritation and redness
of the cheek and nose area.
[0044] The smoker lines above her upper lip have flattened out.
[0045] The chin showed less sagging, skin tightening, less
roughness, and diminished fine lines.
[0046] An overall reduction of wrinkles, better hydration of skin,
and improvement of skin tone, dullness, blotchiness, and appearance
of dark spots were observed.
[0047] Data were also obtained from Image Pro I. RBG spots and UV
spots were measured for each captured image. Results were from
comparisons of images captured on the start and end dates of the
trial. The data showed improvements in both RBG spots and UV
spots.
[0048] Patient indicated significant improvements in the following
aspects: wrinkles, sagging skin, age spots/discoloration, skin
texture, rosacea, dark spots, irritated skin, dry patches/spots,
redness, dull skin, radiance, suppleness, and lifting around the
eye.
[0049] Patient's comments included: "My skin in particular became
softer than I have ever experienced. People commented how soft and
radiant it looks. There is a brightness and radiance and highly
toned, I had irritation across bridge of nose that dissipated and I
was very pleased with this procedure." "There is less wrinkles,
more firmness and improvement in dark spots," "skin is more
hydrated".
[0050] (3) Patient C
[0051] Patient C was a 68-year-old female complaining of roughness
and unevenness of the skin of her face, dry skin with large skin
pores, overall facial sagging especially in the s upper eyelids,
cheek and chin area, deep wrinkles, and dark/age spots all over her
face especially under both eyes.
[0052] Patient C's initial clinical observations included: (1)
overall facial roughness and loose skin, (2) sagging in her upper
eyelids, cheek and chin, (3) slight irritation and blotchiness on
both cheeks, (4) deep nasal labial lines extending to chin area
with to puffiness by jaw, (5) wrinkles on her forehead, around the
eyes, upper lip, cheek, and chin area, (6) unevenness of skin, (7)
dark/age spots on her forehead, nose, and cheeks, (8) dull skin,
and (9) blackheads.
[0053] Patient C was prescribed the 1:20 extract solution of
Dendrobium Huoshanense. She was instructed to apply the extract
twice daily, i.e., 10 drops in the morning and 10 drops in the
evening, on clean face. Patient C followed the regiment for eight
weeks.
[0054] The results of the eight-week clinical trial are summarized
below.
[0055] The frown lines on Patient C's forehead have decreased in
length and depth.
[0056] The ridges on the bridge of her nose were significantly
reduced in depth. There was also a significant decrease in the
appearance of fine lines in that area.
[0057] The upper eyelids showed lifting, less sagging, and
diminished appearance of fine lines. The crows feet along the left
eye and the right eye have significantly diminished.
[0058] An overall reduction of wrinkles, better hydration of skin,
and improvement in skin tone, dullness, blotchiness, and dark spots
were observed.
[0059] Data were also obtained from Image Pro I. RBG spots and UV
spots were measured for each captured image. Results were from
comparisons of images captured on the start and end dates of the
trial. The data showed improvements in both RBG spots and UV
spots.
[0060] Patient C indicated significant improvements in the
following aspects: overall wrinkles, wrinkles and lifting around
the eyes, sagging skin, age spots/discoloration, skin texture, dark
spots, dry patches/spots, redness, dull skin, radiance, and
suppleness.
[0061] Patient C's comments include: "I could not believe the
change in my skin. I became soft, smooth and radiant. I feel that
this is a product I would want to use every day. I have less
wrinkles, more firmness and very moist."
OTHER EMBODIMENTS
[0062] All of the features disclosed in this specification may be
combined in any combination. Each feature disclosed in this
specification may be replaced by an alternative feature serving the
same, equivalent, or similar purpose. Thus, unless expressly stated
otherwise, each feature disclosed is only an example of a generic
series io of equivalent or similar features.
[0063] From the above description, one skilled in the art can
easily ascertain the essential characteristics of the present
invention, and without departing from the spirit and scope thereof,
can make various changes and modifications of the invention to
adapt it to various usages and conditions. Thus, other embodiments
are also within the claims.
* * * * *