U.S. patent application number 14/775254 was filed with the patent office on 2016-02-04 for constant force syringe.
The applicant listed for this patent is BAYER MEDICAL CARE INC.. Invention is credited to KEVIN P. COWAN, BARRY L. TUCKER.
Application Number | 20160030674 14/775254 |
Document ID | / |
Family ID | 51530721 |
Filed Date | 2016-02-04 |
United States Patent
Application |
20160030674 |
Kind Code |
A1 |
COWAN; KEVIN P. ; et
al. |
February 4, 2016 |
CONSTANT FORCE SYRINGE
Abstract
Various syringe systems are disclosed. One such syringe system
may include a body having a hollow lumen and a distal end, a vacuum
chamber disposed within the hollow lumen of the syringe body, a
first plunger connected to a distal portion of the vacuum chamber,
the first plunger forming a first seal against an inner surface of
the syringe body and defining a fluid volume between the first
plunger and the distal end of the syringe body, a second plunger
disposed within the vacuum chamber, the second plunger forming a
second seal against an inner surface of the vacuum chamber and
defining proximal and distal volume compartments within the vacuum
chamber, and a piston affixed to the second plunger, the piston
configured to move the second plunger within the vacuum chamber,
thereby altering a volume of the proximal volume compartment and a
volume of the distal volume compartment.
Inventors: |
COWAN; KEVIN P.; (ALLISON
PARK, PA) ; TUCKER; BARRY L.; (VERONA, PA) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
BAYER MEDICAL CARE INC. |
Indianola, |
PA |
US |
|
|
Family ID: |
51530721 |
Appl. No.: |
14/775254 |
Filed: |
March 11, 2014 |
PCT Filed: |
March 11, 2014 |
PCT NO: |
PCT/US14/23214 |
371 Date: |
September 11, 2015 |
Current U.S.
Class: |
604/121 ;
604/227 |
Current CPC
Class: |
A61M 5/3137 20130101;
A61M 5/14526 20130101; A61M 5/16877 20130101; A61M 2005/3123
20130101; A61M 5/3148 20130101; A61M 5/007 20130101; A61M 5/31515
20130101; A61M 2005/3139 20130101; A61M 2005/3128 20130101; A61M
5/36 20130101; A61M 2202/0007 20130101; A61M 5/2053 20130101; A61M
5/48 20130101 |
International
Class: |
A61M 5/31 20060101
A61M005/31 |
Foreign Application Data
Date |
Code |
Application Number |
Mar 12, 2013 |
US |
13797959 |
Claims
1. A syringe system comprising: a syringe body comprising a hollow
lumen and a distal end, the syringe body being configured to
receive a fluid therein; a vacuum chamber disposed within the
hollow lumen of the syringe body; a first plunger connected to a
distal portion of the vacuum chamber within the hollow lumen of the
syringe body, the first plunger forming a first seal against an
inner surface of the syringe body and defining a fluid volume
between the first plunger and the distal end of the syringe body; a
second plunger disposed within the vacuum chamber, the second
plunger forming a second seal against an inner surface of the
vacuum chamber and defining a proximal volume compartment and a
distal volume compartment within the vacuum chamber; a vent within
one of the proximal volume compartment and the distal volume
compartment of the vacuum chamber, wherein the vent is configured
to allow communication of air between an area outside the syringe
system and one of the proximal volume compartment and the distal
volume compartment; and a piston affixed to the second plunger and
extending proximally out of the vacuum chamber, the piston
configured to move the second plunger within the vacuum chamber,
thereby altering a volume of the proximal volume compartment and a
volume of the distal volume compartment.
2. The syringe system of claim 1, wherein the vent comprises a bore
extending therethrough the piston and the second plunger, the bore
configured to allow communication of air between an area outside
the syringe system and one of the proximal volume compartment and
the distal volume compartment.
3. The syringe system of claim 2, further comprising a valve
configured to regulate an amount of the air communicated between
the area outside the syringe system and one of the proximal volume
compartment and the distal volume compartment.
4. The syringe system of claim 1, wherein the vent comprises a side
vent extending through a wall in one of the proximal volume
compartment and the distal volume compartment of the vacuum
chamber, wherein the side vent is configured to allow communication
of air between an area outside the syringe system and one of the
proximal volume compartment and the distal volume compartment.
5. The syringe system of claim 1, further comprising a tip at the
distal end of the syringe body, wherein the tip is configured to
allow fluid from the fluid volume to pass therethrough upon
movement of the first plunger.
6. The syringe system of claim 5, wherein the tip is further
configured to attach to one or more tubes, needles, or nozzles for
delivery of the fluid to a patient.
7. The syringe system of claim 1, wherein the piston extends
proximally out of the vacuum chamber through a proximal wall,
forming a third seal between the piston and the proximal wall.
8. The syringe system of claim 1, wherein a force exacted upon the
piston in a substantially distal direction is configured to cause
the second plunger to move distally within the vacuum chamber,
thereby increasing the volume of the proximal volume compartment
and decreasing the volume of the distal volume compartment,
creating a pressure difference between the proximal volume
compartment and the distal volume compartment, which causes the
vacuum chamber and the first plunger to move in a distal direction,
thereby expelling the fluid located in the fluid volume through a
tip at the distal end of the syringe body.
9. The syringe system of claim 1, wherein a force exacted upon the
piston in a substantially proximal direction is configured to cause
the second plunger to move proximally within the vacuum chamber,
thereby increasing the volume of the distal volume compartment and
decreasing the volume of the proximal volume compartment, creating
a pressure difference between the proximal volume compartment and
the distal volume compartment, which causes the vacuum chamber and
the first plunger to move in a proximal direction, thereby
aspirating the fluid into the fluid volume through a tip at the
distal end of the syringe body.
10. A syringe system comprising: a syringe body comprising a hollow
lumen and a distal end, the syringe body being configured to
receive a fluid therein; a vacuum chamber at least partially
disposed within the hollow lumen of the syringe body; a first
plunger disposed distally to the vacuum chamber within the hollow
lumen of the syringe body, the first plunger forming a seal against
an inner surface of the syringe body and defining a fluid volume
between the first plunger and the distal end of the syringe body; a
second plunger disposed within the vacuum chamber, the second
plunger defining a proximal volume compartment and a distal volume
compartment within the vacuum chamber; a side vent extending
through a wall in one of the distal volume compartment and the
proximal volume compartment of the vacuum chamber, wherein the side
vent is configured to allow communication of air between an area
outside the syringe system and one of the proximal volume
compartment and the distal volume compartment; and a piston
extending distally out of the vacuum chamber and connected to the
first plunger and the second plunger, the piston configured to move
the second plunger within the vacuum chamber and the first plunger
within the syringe body.
11. The syringe system of claim 10, further comprising a tip at the
distal end of the syringe body, wherein the tip is configured to
allow fluid from the fluid volume to pass therethrough upon
movement of the first plunger.
12. The syringe system of claim 11, wherein the tip is further
configured to attach to one or more tubes, needles, or nozzles for
delivery of the fluid to a patient.
13. The syringe system of claim 10, wherein a force exacted upon
the vacuum chamber in a substantially distal direction is
configured to cause the vacuum chamber to move distally within the
syringe body, thereby decreasing the volume of the proximal volume
compartment and increasing the volume of the distal volume
compartment, creating a pressure difference between the proximal
volume compartment and the distal volume compartment, which causes
the second plunger, the piston, and the first plunger to move in a
distal direction, thereby expelling the fluid located in the fluid
volume through a tip at the distal end of the syringe body.
14. The syringe system of claim 10, wherein a force exacted upon
the piston in a substantially proximal direction is configured to
cause the second plunger to move proximally within the vacuum
chamber, thereby increasing the volume of the distal volume
compartment and decreasing the volume of the proximal volume
compartment, creating a pressure difference between the proximal
volume compartment and the distal volume compartment, which causes
the vacuum chamber and the first plunger to move in a proximal
direction, thereby aspirating the fluid into the fluid volume
through a tip at the distal end of the syringe body.
15. A syringe system comprising: a syringe body comprising a hollow
lumen and a distal end having a tip, the syringe body being
configured to receive a fluid therein; a vacuum chamber at least
partially disposed within the hollow lumen of the syringe body; a
first plunger disposed distally to the vacuum chamber within the
hollow lumen of the syringe body, the first plunger forming a seal
against an inner surface of the syringe body and defining a fluid
volume between the first plunger and the distal end of the syringe
body; a second plunger disposed within the vacuum chamber, the
second plunger defining a proximal volume compartment and a distal
volume compartment within the vacuum chamber; a piston extending
distally out of the vacuum chamber and connected to the first
plunger and the second plunger, wherein the piston is configured to
move the second plunger within the vacuum chamber and the first
plunger within the syringe body; and a thumb piece removably
attached to a proximal portion of the vacuum chamber, wherein the
thumb piece is configured to provide a surface for a user to apply
a force in a substantially axial direction, and wherein the thumb
piece is further configured to increase and decrease a volume of
one of the distal volume compartment and the proximal volume
compartment.
16. The syringe system of claim 15, wherein the thumb piece is
configured to increase and decrease the volume of one of the distal
volume compartment and the proximal volume compartment by screwing
into at least a portion of the vacuum chamber.
17. The syringe system of claim 15, wherein the thumb piece is
configured to move in a distal direction, wherein the vacuum
chamber is configured to move within the syringe body in response
to movement of the thumb piece, wherein the second plunger, the
piston, and the first plunger are configured to move in response to
the vacuum chamber moving within the syringe body.
18. (canceled)
19. (canceled)
20. (canceled)
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. application Ser.
No. 13/797,959, filed Mar. 12, 2013, entitled "Constant Force
Syringe", the disclosure of which is hereby incorporated by
reference it its entirety.
BACKGROUND OF THE DISCLOSURE
[0002] 1. Field of the Disclosure
[0003] The present application relates, in general, to a syringe,
and, in particular, to a constant force syringe for administration
and aspiration of medications, supplements, fluids, contrast media,
and/or the like at a constant rate.
[0004] 2. Description of the Related Art
[0005] During various medical procedures, it may be necessary to
administer and/or aspirate medications, supplements, fluids,
contrast media, saline, and/or the like to and from a patient or a
fluid container. In general, administration and aspiration may
occur subcutaneously, intramuscularly, intraperitoneally, and/or
intravenously. In some instances, administration may be
accomplished with the use of a manually activated syringe. In other
instances, administration and/or aspiration may occur to and from a
fluid container.
[0006] Occasionally, a constant rate of administration or
aspiration may be of particular concern to the medical services
provider and/or the patient. In an illustrative example, biological
cells included in some treatments may be susceptible to damage if
the pressure (or vacuum) and/or the flow rate of the
injection/aspiration is too high. Furthermore, damage to the
biological cells may reduce the efficacy of treatment. In another
illustrative example, the rate of delivery/aspiration may be
important to ensure proper uptake of an agent. Even the most
skilled medical services provider may struggle with the process of
smoothly administering/aspirating at a constant rate.
[0007] Cells are sensitive to shear forces and turbulence generated
during a collection procedure. Non-constant rate or a rate above a
cell lysis threshold can cause the rupture or the destruction of
the cells. When the cell structure is compromised in this manner, a
collected fluid specimen may not be identical to the fluid in the
environment from which it is collected.
[0008] Previous attempts to ensure smooth administration and/or
aspiration of medications, supplements, fluids, contrast media,
and/or the like at a constant rate have resulted in injector
systems that are used to administer and/or aspirate a fluid at a
constant rate that are complicated and expensive to use and
implement.
SUMMARY OF THE DISCLOSURE
[0009] In an embodiment, a syringe system may include a syringe
body having a hollow lumen and a distal end. The syringe body may
be configured to receive a fluid therein. A vacuum chamber may be
disposed within the hollow lumen of the syringe body. A first
plunger may be connected to a distal portion of the vacuum chamber
within the hollow lumen of the syringe body. The first plunger may
form a first seal against an inner surface of the syringe body and
define a fluid volume between the first plunger and the distal end
of the syringe body. A second plunger may be disposed within the
vacuum chamber. The second plunger may form a second seal against
an inner surface of the vacuum chamber and define a proximal volume
compartment and a distal volume compartment within the vacuum
chamber. A vent may be provided within one of the proximal volume
compartment and the distal volume compartment of the vacuum
chamber. The vent may be configured to allow communication of air
between an area outside the syringe system and one of the proximal
volume compartment and the distal volume compartment. A piston may
be affixed to the second plunger and extend proximally out of the
vacuum chamber. The piston may be configured to move the second
plunger within the vacuum chamber, thereby altering a volume of the
proximal volume compartment and a volume of the distal volume
compartment.
[0010] In another embodiment, the vent may include a bore extending
therethrough the piston and the second plunger, where the bore is
configured to allow communication of air between an area outside
the syringe system and one of the proximal volume compartment and
the distal volume compartment. A valve may be provided to regulate
an amount of the air communicated between the area outside the
syringe system and one of the proximal volume compartment and the
distal volume compartment. The vent may include a side vent
extending through a wall in one of the proximal volume compartment
and the distal volume compartment of the vacuum chamber. The side
vent may be configured to allow communication of air between an
area outside the syringe system and one of the proximal volume
compartment and the distal volume compartment.
[0011] In another embodiment, a tip may be provided at the distal
end of the syringe body. The tip may be configured to allow fluid
from the fluid volume to pass therethrough upon movement of the
first plunger. The tip may be further configured to attach to one
or more tubes, needles, or nozzles for delivery of the fluid to a
patient. The piston may extend proximally out of the vacuum chamber
through a proximal wall, forming a third seal between the piston
and the proximal wall.
[0012] In another embodiment, a force exacted upon the piston in a
substantially distal direction may be configured to cause the
second plunger to move distally within the vacuum chamber, thereby
increasing the volume of the proximal volume compartment and
decreasing the volume of the distal volume compartment, creating a
pressure difference between the proximal volume compartment and the
distal volume compartment, which causes the vacuum chamber and the
first plunger to move in a distal direction, thereby expelling the
fluid located in the fluid volume out of a tip in the distal end of
the syringe body. Alternatively, a force exacted upon the piston in
a substantially proximal direction may be configured to cause the
second plunger to move proximally within the vacuum chamber,
thereby increasing the volume of the distal volume compartment and
decreasing the volume of the proximal volume compartment, creating
a pressure difference between the proximal volume compartment and
the distal volume compartment, which causes the vacuum chamber and
the first plunger to move in a proximal direction, thereby
aspirating the fluid into the fluid volume through a tip in the
distal end of the syringe body.
[0013] In another embodiment, a syringe system may include a
syringe body having a hollow lumen and a distal end. The syringe
body may be configured to receive a fluid therein. A vacuum chamber
may be at least partially disposed within the hollow lumen of the
syringe body. A first plunger may be disposed distally to the
vacuum chamber within the hollow lumen of the syringe body. The
first plunger may form a seal against an inner surface of the
syringe body and define a fluid volume between the first plunger
and the distal end of the syringe body. A second plunger may be
disposed within the vacuum chamber to define a proximal volume
compartment and a distal volume compartment within the vacuum
chamber. A side vent may extend through a wall in one of the distal
volume compartment and the proximal volume compartment of the
vacuum chamber. The side vent may be configured to allow
communication of air between an area outside the syringe system and
one of the proximal volume compartment and the distal volume
compartment. A piston may extend distally out of the vacuum chamber
and connect to the first plunger and the second plunger. The piston
may be configured to move the second plunger within the vacuum
chamber and the first plunger within the syringe body.
[0014] In another embodiment, a tip may be provided at the distal
end of the syringe body. The tip may be configured to allow fluid
from the fluid volume to pass therethrough upon movement of the
first plunger. The tip may be further configured to attach to one
or more tubes, needles, or nozzles for delivery of the fluid to a
patient.
[0015] In another embodiment, a force exacted upon the vacuum
chamber in a substantially distal direction may be configured to
cause the vacuum chamber to move distally within the syringe body,
thereby decreasing the volume of the proximal volume compartment
and increasing the volume of the distal volume compartment,
creating a pressure difference between the proximal volume
compartment and the distal volume compartment, which causes the
second plunger, the piston, and the first plunger to move in a
distal direction, thereby expelling the fluid located in the fluid
volume out of a tip in the distal end of the syringe body.
Alternatively, a force exacted upon the piston in a substantially
proximal direction may be configured to cause the second plunger to
move proximally within the vacuum chamber, thereby increasing the
volume of the distal volume compartment and decreasing the volume
of the proximal volume compartment, creating a pressure difference
between the proximal volume compartment and the distal volume
compartment, which causes the vacuum chamber and the first plunger
to move in a proximal direction, thereby aspirating the fluid into
the fluid volume through a tip in the distal end of the syringe
body.
[0016] In yet another embodiment, a syringe system may include a
syringe body having a hollow lumen and a distal end having a tip.
The syringe body may be configured to receive a fluid therein. A
vacuum chamber may be at least partially disposed within the hollow
lumen of the syringe body. A first plunger may be disposed distally
to the vacuum chamber within the hollow lumen of the syringe body
and form a seal against an inner surface of the syringe body,
thereby defining a fluid volume between the first plunger and the
distal end of the syringe body. A second plunger may be disposed
within the vacuum chamber, the second plunger defining a proximal
volume compartment and a distal volume compartment within the
vacuum chamber. A piston may extend distally out of the vacuum
chamber and be connected to the first plunger and the second
plunger. The piston may be configured to move the second plunger
within the vacuum chamber and the first plunger within the syringe
body.
[0017] In another embodiment, a thumb piece may be removably
attached to a proximal portion of the vacuum chamber. The thumb
piece may be configured to provide a surface for a user to apply a
force in a substantially axial direction. The thumb piece may be
further configured to increase and decrease a volume of one of the
distal volume compartment and the proximal volume compartment. The
thumb piece may be configured to increase and decrease the volume
of one of the distal volume compartment and the proximal volume
compartment by screwing into at least a portion of the vacuum
chamber. The thumb piece may be configured to move in a distal
direction, wherein the vacuum chamber is configured to move within
the syringe body in response to movement of the thumb piece. The
second plunger, the piston, and the first plunger may be configured
to move in response to the vacuum chamber moving within the syringe
body.
[0018] In another embodiment, a syringe system may include a
syringe body having a hollow lumen and a distal end having a tip.
The syringe body may be configured to receive a fluid therein. A
vacuum chamber may be at least partially disposed within the hollow
lumen of the syringe body. A first plunger may be disposed distally
to the vacuum chamber within the hollow lumen of the syringe body.
The first plunger may form a seal against an inner surface of the
syringe body and define a fluid volume between the first plunger
and the distal end of the syringe body. A second plunger may be
disposed within the vacuum chamber. The second plunger may define a
proximal volume compartment and a distal volume compartment within
the vacuum chamber. A thumb piece may be configured to screw into a
proximal portion of the vacuum chamber. The thumb piece may be
configured to increase and decrease a volume of one of the distal
volume compartment and the proximal volume compartment. A piston
may extend distally out of the vacuum chamber and be connected to
the first plunger and the second plunger. The piston may be
configured to move the second plunger within the vacuum chamber and
the first plunger within the syringe body. A guide may be provided
on an outside surface of the vacuum chamber, such that the guide is
configured to assist a user of the syringe system to screw the
thumb piece to a desired depth in the vacuum chamber to ensure a
desired volume of one of the distal volume compartment and the
proximal volume compartment. The thumb piece may be further
configured to increase and decrease a flow rate of the fluid out of
the syringe system.
BRIEF DESCRIPTION OF THE DRAWINGS
[0019] FIG. 1A depicts a side view of a syringe having a vent
according to an embodiment.
[0020] FIG. 1B depicts a side view of a syringe having an angled
bore according to an embodiment.
[0021] FIG. 1C depicts a side view of a syringe having a bore that
extends through the thumb piece according to an embodiment.
[0022] FIG. 2A depicts a side view of an alternative syringe having
a side vent according to an embodiment.
[0023] FIG. 2B depicts a side view of an alternative syringe having
a screw-on thumb piece according to an embodiment.
[0024] FIGS. 3A-3B depict movement of the various components of the
syringe depicted in FIG. 1A according to an embodiment.
[0025] FIGS. 4A-4C depict movement of the various components of the
syringe depicted in FIG. 2A according to an embodiment.
[0026] FIGS. 5A-5C depict movement of the various components of the
syringe depicted in FIG. 2B according to an embodiment.
[0027] FIG. 6A depicts a side view of a syringe having a vent
according to an embodiment.
[0028] FIG. 6B depicts a side view of a syringe having an angled
bore according to an embodiment.
[0029] FIG. 6C depicts a side view of a syringe having a bore that
extends through the thumb piece according to an embodiment.
[0030] FIG. 7A depicts a side view of an alternative syringe having
a side vent according to an embodiment.
[0031] FIG. 7B depicts a side view of an alternative syringe having
a screw-on thumb piece according to an embodiment.
[0032] FIGS. 8A-8B depict movement of the various components of the
syringe depicted in FIG. 6A according to an embodiment.
[0033] FIGS. 9A-9C depict movement of the various components of the
syringe depicted in FIG. 7A according to an embodiment.
[0034] FIGS. 10A-10C depict movement of the various components of
the syringe depicted in FIG. 7B according to an embodiment.
DETAILED DESCRIPTION OF THE DISCLOSURE
[0035] This disclosure is not limited to the particular systems,
devices and methods described, as these may vary. The terminology
used in the description is for the purpose of describing the
particular versions or embodiments only, and is not intended to
limit the scope.
[0036] As used in this document, the singular forms "a," "an," and
"the" include plural references unless the context clearly dictates
otherwise. Unless defined otherwise, all technical and scientific
terms used herein have the same meanings as commonly understood by
one of ordinary skill in the art. Nothing in this disclosure is to
be construed as an admission that the embodiments described in this
disclosure are not entitled to antedate such disclosure by virtue
of prior disclosure. As used in this document, the term
"comprising" means "including, but not limited to."
[0037] For purposes of the description hereinafter, the terms
"upper," "lower," "right," "left," "vertical," "horizontal," "top,"
"bottom," "lateral," "longitudinal," and derivatives thereof shall
relate to the orientation of embodiments disclosed in the figures.
However, embodiments may assume alternative variations and step
sequences, except where expressly specified to the contrary. The
specific devices and processes illustrated in the attached drawings
and described in the following specification, are exemplary
embodiments. Hence, physical characteristics related to the
embodiments disclosed herein are not to be considered as
limiting.
[0038] The word "proximal" refers to a direction relatively closer
to a clinician or operator using the device described herein, and
the word "distal" refers to a direction relatively further from the
clinician or operator. For example, the end of a syringe placed
nearest the body of a patient is considered a distal end of the
syringe, while the end closes to the clinician is a proximal end of
the syringe. The terms "axial" or "axially" refer generally to an
axis around which the particular objects being referred to are
preferably formed (although not necessarily symmetrically
therearound). The term "radial" refers generally to a direction
normal to the axis or along a radius of an object having a circular
cross-section.
[0039] Various embodiments of the present disclosure may be
directed to syringes, particularly those used for manual fluid
delivery and aspiration, that may rely on a transient vacuum
induced within one or more compartments of the syringe. In some
embodiments, the fluid may be delivered from the syringe at a
uniform rate because the vacuum itself powers the fluid delivery or
aspiration, as applicable, instead of the person or device pressing
on the thumb piece of the syringe.
[0040] FIG. 1A depicts a side view of a syringe, generally
designated 100, having a vent 135 according to an embodiment. The
syringe 100 may generally include a syringe body 105 having a
hollow lumen 107, a proximal end 101, and a distal end 102 having a
tip 110. The syringe body 105 is not limited in shape or size by
this disclosure, and may be any shape or size, particularly shapes
and sizes of syringe bodies commonly known by those skilled in the
art. In various embodiments, the syringe body 105 may be
substantially cylindrical. In various embodiments, the syringe body
105 may be about 4 ml to about 20 ml in volume. In particular
embodiments, the volume of the syringe body 105 may be about 4 ml,
about 5 ml, about 10 ml, about 15 ml, about 20 ml, or any value or
range between any two of these values. In various embodiments, the
syringe 100 may be made of glass, a polymer, and/or the like.
[0041] In various embodiments, the hollow lumen 107 may include a
plurality of plungers disposed therein. For example, in the present
embodiment, the hollow lumen 107 may have a first plunger 125 and a
second plunger 150. However, those skilled in the art will
recognize that more than two plungers may be used without departing
from the scope of this disclosure. In some embodiments, a vacuum
chamber 120 may be disposed within the syringe body 105 in contact
with the first plunger 125. In various embodiments, the first
plunger 125 may form a seal against the interior of the syringe
body 105 by means of a first seal 130. In some embodiments, the
first seal 130 may be a separate component from the first plunger
125, such as, for example, an added O-ring and/or the like. In
these embodiments, the first seal 130 may be fixedly attached to
the first plunger 125 by any means of attachment, including
attachment apparatuses, adhesives, and/or the like, or the first
seal may removably attached to the first plunger. In other
embodiments, the first seal 130 may be fabricated as a portion of
the first plunger 125. In some embodiments, the first seal 130 may
be associated with a distal portion of the vacuum chamber 120.
[0042] In various embodiments, the second plunger 150 may be
disposed within the vacuum chamber 120. In some embodiments, the
second plunger 150 may be mechanically activated by a piston 155.
The second plunger 150 may be attached to the piston 155 by any
means of attachment, including, but not limited to, any number of
clips, fasteners, hooks, adhesives, and/or the like. In some
embodiments, the second plunger 150 may be molded as a portion of
the piston 155. In some embodiments, the piston 155 may at least
partially extend out of an opening of the proximal end 101 of the
syringe body 105. In some embodiments, the piston 155 may generally
extend out of the vacuum chamber 120 through a proximal wall 140.
The opening in the proximal wall 140 may be sealed with a second
seal 145 to the piston 155. The second seal 145 may be an air-tight
seal around the shaft of the piston 155. In some embodiments, in
lieu of the vent 135, the piston 155 may contain a bore
therethrough, such as 180 in FIG. 1B or 180' in FIG. 1C, as
described in greater detail herein.
[0043] In various embodiments, a proximal portion of the piston 155
may be connected to a thumb piece 160. The thumb piece 160 may
generally provide a surface upon which a user's digits or another
device applies a force to move the piston 155 in either a distal or
proximal direction. The thumb piece 160 depicted herein is a
generally flat surface; however, those skilled in the art will
recognize that the shape and size of the thumb piece is not limited
by this disclosure, and may include any number of rings, openings,
contoured surfaces, and/or the like without departing from the
scope of the present disclosure. Persons skilled in the art will
also note that the term `thumb piece` is not intended to be
limiting; while a thumb may be a preferred digit for manipulating
the thumb piece 160, the user may use any object to manipulate the
thumb piece as described herein. In an illustrative example, a user
may press his/her thumb against the thumb piece 160 to effect
distal movement of the piston 155 and/or other components of the
syringe 100, as described in greater detail herein.
[0044] Similar to the first plunger 125 described herein, in
various embodiments, the second plunger 150 may form an airtight
seal against an interior surface of the vacuum chamber 120, thereby
dividing the vacuum chamber into two volume compartments. A distal
volume compartment 165 may be created by the space between a distal
surface of the second plunger 150 and a proximal end of the first
plunger 125. A proximal volume compartment 170 may be created by
the space between a proximal surface of the second plunger 150 and
a distal surface of the proximal wall 140 of the vacuum chamber
120.
[0045] In various embodiments, the vacuum chamber 120 may be
detachable from the first plunger 125. The ability to detach the
vacuum chamber 120 from the first plunger 125 may allow for use of
vacuum chambers that vary in size and shape, thereby increasing
compatibility with a wide range of forces to allow for varying
pressures and flow rates, as described in greater detail
herein.
[0046] In various embodiments, the vacuum chamber 120 may include a
vent 135. The vent 135 may generally be an opening within the
vacuum chamber to allow fluid communication of air between the
distal volume compartment 165 and an area outside the syringe body
105. In some embodiments, the communication between the vent 135
and the area outside the syringe body 105 may be along a path
bounded by the inner surface of the syringe body and the outer
surface of the vacuum chamber 120.
[0047] In various embodiments, a fluid delivery volume 175 may be
defined within the syringe body 105. In some embodiments, the fluid
delivery volume 175 may be defined as the space that is located
distally to the first plunger 125. In some embodiments, the fluid
delivery volume 175 may contain a fluid therein. Examples of fluids
are not limited by this disclosure, and may include, for example,
medications, supplements, bodily fluids, contrast media, saline,
and/or the like. In some embodiments, fluid contained within the
fluid delivery volume 175 may be delivered through the tip 110. The
tip 110 may further be configured to be connected to additional
elements, such as, for example, needles, tubes, nozzles, and/or the
like for delivery of the fluid. It may be appreciated that the
first seal 130 may be configured to prevent air transfer from
either outside the syringe body 105 or the vacuum chamber 165 from
entering the delivery volume 175. Similarly, the first seal 130 may
be configured to prevent air and/or fluid from escaping the
delivery volume 175 into the vacuum chamber 165 and/or the
remainder of the syringe body 105. The volume of the delivery
volume 175 may be determined by the distance between the first
plunger 125 and the distal end 102 of the syringe body 105, as well
as the circumference of the syringe body.
[0048] In various embodiments, one or more finger guards 115 may be
positioned at a location that is generally located at or near the
proximal end 101 of the syringe body 105. In some embodiments, the
finger guards 115 may generally be located on an outside surface of
the syringe body 105 and may generally extend from the outside
surface of the syringe body. In some embodiments, the finger guards
115 may act to provide stability to the syringe 100 during
operation. In some embodiments, a user may use the finger guards
115 to prevent movement of the syringe 100 during operation. In
some embodiments, the user may use the finger guards 115 to prevent
the syringe 100 from slipping out of the user's hand. In some
embodiments, the user may use the finger guards 115 to protect the
user's fingers. In some embodiments, the finger guards 115 may act
as a stopping device to prevent the piston 155 from moving further
distally inside the syringe body 105. The shape and size of the
finger guards 115 are not limited by this disclosure, and may be
any shape and/or size known in the art. Specific examples of shapes
may be ring shaped, wedge shaped, and/or the like.
[0049] In various embodiments, as depicted in FIGS. 1B and 1C, the
bore 180, 180' may be used in lieu of the vent 135 (FIG. 1A). In
some embodiments, the bore 180, 180' may extend through at least a
portion of the piston 155 and/or the second plunger 150. In some
embodiments, the bore 180, 180' may be configured to allow air from
outside the syringe 100 to enter and/or escape the vacuum chamber
120, effectively regulating by increasing and/or decreasing the
pressure of air inside the vacuum chamber. In some embodiments, the
bore 180 may include a bore outlet 181 containing a valve and/or
the like to assist in regulation of air pressure inside the vacuum
chamber 120. In some embodiments, the valve may be incorporated
within the thumb piece 160. In other embodiments, the valve may be
a separate element, such as a one way check valve or the like. In
yet other embodiments, a user may use his/her finger to block the
bore 180 in a manner similar to that of a valve. In some
embodiments, such as the syringe shown in FIG. 1B, the bore 180 may
be curved or angled so that the bore outlet 181 is located
substantially on a side of the piston 155, such as, for example, a
top side, a bottom side, or the like. In other embodiments, such as
the syringe shown in FIG. 1C, the bore 180' may be substantially
straight and/or linear with the piston 155. Such a configuration
may allow for the bore outlet 181' to be located at or near the
thumb piece 160. In some embodiments with this configuration, the
thumb piece 160 may act as the valve to block the bore outlet 181',
as previously described herein. In other embodiments with this
configuration, a user may block the bore outlet 181' with an
external apparatus, a thumb, and/or the like while manipulating the
thumb piece 160 at the same time.
[0050] FIG. 2A depicts a side view of an alternative syringe,
generally designated 200, according to an embodiment. Similar to
the syringe 100 disclosed with respect to FIGS. 1A-1C above, the
syringe 200 may include a syringe body 205 having a proximal end
201 and a distal end 202. In some embodiments, the syringe body 205
may include a first plunger 225 disposed therein, the plunger
incorporating a first seal 230, as previously described herein. A
delivery volume 275 may be formed between the distal surface of the
first plunger 225 and the tip, as previously described herein.
[0051] In various embodiments, a vacuum chamber 220 may be disposed
within the syringe body 205. In some embodiments, the vacuum
chamber 220 may be bounded by a distal wall 240 and a proximal
thumb piece 260. In some embodiments, at least a portion of the
vacuum chamber 220 may contain air that is pressurized to a
pressure at or above standard atmospheric air pressure at sea
level, as described in greater detail herein. In other embodiments,
at least a portion of the vacuum chamber 220 may contain air that
is pressurized to a pressure below standard atmospheric air
pressure at sea level, as described in greater detail herein.
[0052] In various embodiments, the first plunger 225 may be
mechanically coupled via a piston 255 to the second plunger 250.
The first plunger 225 may generally be disposed at a location
inside the syringe body 205, as previously described herein, and
further disposed at a location that is distal to the vacuum chamber
220. In some embodiments, the positioning of the first plunger 225
and the vacuum chamber 220 may define a medial compartment 285
therebetween. Particularly, the medial compartment 285 may be
formed between the proximal surface of the first plunger 225 and
the distal surface of the distal wall 240. In some embodiments, the
piston 255 may traverse the medial compartment 285 and extend into
the vacuum chamber 220 through the distal wall 240. In some
embodiments, the piston 255 may be attached by any means of
attachment to the first plunger 225 and/or the second plunger 250.
In some embodiments, the piston 255 may be molded as a portion of
the first plunger 225 and/or the second plunger 250. In some
embodiments, the piston 255 may be detachable from the first
plunger 225 and/or the second plunger 250. The ability to detach
the piston 255 from the plungers 225, 250 may allow for the piston
to be used with varying plungers, thereby increasing compatibility
with a wide range of syringes of different sizes and shapes,
lowering operating costs, lowering manufacturing costs, enabling
the use pre-filled syringes, and/or the like.
[0053] In various embodiments, the second plunger 250 may be
located within the vacuum chamber 220. As in the embodiments
depicted herein with respect to FIGS. 1A-1C, the second plunger 250
may be configured to form an airtight seal against an interior
surface of the vacuum chamber 220, thereby dividing the vacuum
chamber into two compartments. A distal volume compartment 265 may
be created by the space between a distal surface of the second
plunger 250 and the distal wall 240 of the vacuum chamber 220. A
proximal volume compartment 270 may be created by the space between
a proximal surface of the second plunger 250 and a distal surface
of the thumb piece 260.
[0054] In various embodiments, a second seal 245 may be positioned
within the distal wall 240 around the piston 255 to form an
airtight seal around the piston. In some embodiments, the second
seal 245 may prevent air from entering and/or escaping from the
distal volume compartment 265 when the piston 255 is actuated. In
some embodiments, the distal volume compartment 265 may be sealed
and/or evacuated before the syringe 200 is used.
[0055] In optional embodiments, the vacuum chamber 220 may include
a vent 235. The vent 235 may generally be an opening within the
vacuum chamber 220 configured to allow fluid communication of air
between an area outside the syringe body 205 and the proximal
volume compartment 270. The vent 235 may be further configured to
equalize air pressure within the proximal volume compartment 270
with the outside air pressure, as described in greater detail
herein. In some embodiments, the outside air pressure may be about
14.7 psi, or standard atmospheric pressure at sea level.
[0056] As depicted in FIG. 2B, a movable thumb piece 260' may be
used instead of a vent according to some embodiments. The movable
thumb piece 260' may be moved generally distally and/or proximally
by any means of movement, and is not limited by this disclosure. By
way of example only, the movable thumb piece 260' in the present
embodiment may contain a plurality of threads 290 that allow the
thumb piece to be screwed into the vacuum chamber 220. In some
embodiments, the thumb piece 260' may be screwed over the vacuum
chamber 220. In other embodiments, the thumb piece 260' may be
screwed inside the vacuum chamber 220. The thumb piece 260' may be
screwed into a specific depth to obtain a desired pressure inside
the proximal volume compartment 270, as will be described in
greater detail herein. To aid in determining the pressure inside
the proximal volume compartment 270 a guide 295 may be located on
the syringe 200 to aid a user in determining where to position the
thumb piece 260'. For example, the guide 295 may be a plurality of
hash marks printed on an outside surface of the vacuum chamber 220,
wherein each hash mark is labeled with the pressure that will be
achieved by moving the thumb piece 260' to that hash mark. In some
embodiments, the thumb piece 260 may incorporate a display that
indicates the amount of adjusted pressure inside the proximal
volume chamber 270.
[0057] In various embodiments, the syringe 200 may further include
any number of shock absorbing devices (not shown). Specific
examples of shock absorbing devices may include, for example,
springs, air cushions, absorbing materials, and/or the like. The
shock absorbing devices may generally function to ensure a smooth
distribution of fluid out of the tip 210 at a constant rate that
acts supplementary to the driving force cause by the difference in
pressure, as described in greater detail herein.
[0058] FIGS. 3A-3B depict movement of the various components of the
syringe 100 depicted in FIGS. 1A-1C according to an embodiment.
More particularly, FIG. 3A depicts an initial state of the syringe
100. As previously described herein, a force F may be applied to
the thumb piece 160 to force the piston 155 in a distal direction
into the syringe body 105. As a result, the piston 155 may
mechanically force the second plunger 150 to move in a distal
direction within the vacuum chamber 120.
[0059] As described in greater detail herein, the second seal 145
and the second plunger 150 may be configured to prevent air from
entering the proximal volume compartment 170. In addition, the
movement of the second plunger 150 in a distal direction may
increase the volume of the proximal volume compartment 170. In some
instances, this combination may result in a decrease in pressure in
the proximal volume compartment 170 where the proximal volume
compartment has a pressure greater than or equal to zero. However,
in instances where the proximal volume compartment 170 is a vacuum
(thereby having a zero pressure), this combination will not change
the pressure within the proximal volume compartment 170. This is
due to the ideal gas law, which is represented by Equation (1):
PV=nRT (1)
where P is the pressure of the gas, V is the volume of the gas, n
is the amount of substance of gas (also known as number of moles),
T is the temperature of the gas and R is the ideal, or universal,
gas constant, equal to the product of the Boltzmann constant and
the Avogadro constant. To compare different volumes, Equation (1)
can be written to reflect the different volumes as follows:
P.sub.--1V.sub.--1=nR.sub.--1T.sub.--1 and
P.sub.--2V.sub.--2=nR.sub.--2T.sub.--2. If P1 and P2 are both zero
because of the vacuum (zero pressure), then a change in either
volume V1, V2 will not change the results.
[0060] Furthermore, the pressure can be written as a function of
force, as represented by Equation (2):
.DELTA.P=F/A (2)
where .DELTA.P is the change in pressure, F is the normal force,
and A is the area of the surface on contact. Thus, in an
illustrative example, if the pressure P is zero (0 psi), such as in
a vacuum, then according to Equation (1), the pressure will not
change when other variables change, such as, for example, the
volume V. Since the pressure remains the same, the force F that is
exerted by the pressure will also remain constant according to
Equation (2), which allows for a smooth distribution of the fluid
from within the delivery volume 175.
[0061] Similarly, the movement of the second plunger 150 in a
distal direction may decrease the volume of the distal volume
compartment 165. However, due to the location of the vent 135 (or
in some embodiments, the bore 180), the pressure of the distal
volume compartment may equalize with the outside air pressure
(i.e., moving towards about 14.7 psi). As a result the force F may
be active on the second plunger 150 due to the unequal pressure
between the pressure of the distal volume compartment 165 and the
pressure of the proximal volume compartment 170. In some
embodiments, the pressure of the distal volume compartment 165 may
be greater than the pressure of the proximal volume compartment
170. In other embodiments, such as those where it is desired to add
fluid to the syringe 100, the pressure of the distal volume
compartment 165 may be less than the pressure of the proximal
volume compartment 170. In some embodiments, to ensure that the
proximal volume compartment has a lower pressure than the distal
volume compartment 165, the proximal volume compartment may be
pre-evacuated prior to movement of the piston 155. The
pre-evacuation process may be completed, for example, by attaching
a vacuum pump or the like to the proximal volume compartment 170
through a sealable valve and port (not shown).
[0062] In various embodiments, because of the unequal pressure
between the distal volume compartment 165 and the proximal volume
compartment 170, a driving force F' may be active on the vacuum
chamber 120. However, since the user may maintain force on the
thumb piece 160 to keep it in a depressed state, the second plunger
150 may be fixed relative to the syringe body 105. Accordingly, the
pressure difference between the distal volume compartment 165 and
the proximal volume compartment 170 may force the vacuum chamber
120 to shift in the distal direction, thereby driving the first
plunger 125 in a distal direction towards the distal end 102 of the
syringe body 105. The resulting motion of the first plunger 125 may
reduce the delivery volume 175, causing the fluid in the delivery
volume to exit out the tip 110 at a steady rate. Those skilled in
the art may appreciate that the driving force F' on the first
plunger 125 may be due to the pressure difference developed between
the proximal volume compartment 170 and the distal volume
compartment 165, and may not depend on the user's force on the
thumb piece 160. Those skilled in the art may also appreciate that
the driving force F' on the first plunger 125 may not be due to the
position of the second plunger 150 relative to the vacuum chamber
120 and/or the syringe body 105, as long as the second plunger is
not located at the proximal end 101 or the distal end 102 of the
syringe body. Furthermore, the driving force F' on the first
plunger 125 may not be due to the velocity of the second plunger
150 in moving towards the distal end 102 of the syringe body 105
provided that there is only a small amount of friction between the
second plunger and the vacuum chamber 120. Accordingly, the rate of
motion of the first plunger 125 may be smooth and may not reflect
any possible unsteady movement from the user. Furthermore, the rate
of delivery of the fluid from the delivery volume 175 may be
adjusted by the user prior to applying force on the thumb piece 160
by increasing or decreasing the pressure of the distal volume
compartment 165, as described in greater detail herein.
[0063] FIGS. 4A-4C depict the effect on the syringe of FIG. 2A when
a force F is applied to the thumb piece 260 according to various
embodiments. In some embodiments, the force F may cause the thumb
piece 260 to move in a generally distal direction. This movement of
the thumb piece 260 may cause the vacuum chamber 220 to also travel
in a generally distal direction within the syringe body 205. In
some embodiments, the various volume compartments 265, 270 may
change volume as a result of the movement while the pressure
remains the same (i.e., about 14.7 psi in the proximal volume
compartment and zero in the distal volume compartment), as
previously described herein. In some embodiments, the force F
applied to the thumb piece 260 may cause the vacuum chamber 220 to
move relative to the second plunger 250. The movement of the vacuum
chamber 220 may therefore result in an increase in the volume of
the distal volume compartment 265 and a decrease in volume of the
proximal volume compartment 270. In various embodiments, a driving
force F' that pushes the first plunger 225 towards the distal end
202 of the syringe body 205 may result from the difference of
pressure of the proximal volume compartment 270 (where the pressure
is at or near atmospheric pressure, or about 14.7 psi) and the
distal volume compartment 265 (where the pressure is zero) as
described herein. Accordingly, if a user of the syringe 200
provides a sharp force on the thumb piece 260, it will have no
effect on the rate of ejection of fluid from the tip 210 because
the difference in pressures in the distal volume compartment 265
and the proximal volume compartment 270 will continue to remain the
same, even with the distal volume compartment increasing in volume.
In addition, if a faster rate of ejection of fluid from the tip 210
is desired, the vent 235 can be covered with a valve or a user's
finger while a force is exacted upon the thumb piece 260 to
increase the pressure of the proximal volume compartment 270 and
alter the driving force F' accordingly.
[0064] FIGS. 5A-5C depict the effect on the syringe of FIG. 2B when
a force F is applied to the thumb piece 260' according to various
embodiments. The movement of the various components of the syringe
200 is substantially the same as previously described herein with
respect to FIGS. 4A-4C; however, instead of regulating the pressure
of the proximal volume compartment 270 with a vent to increase the
rate of distribution of fluid, the thumb piece 260' may be moved to
adjust the pressure of the proximal volume compartment. For
example, the thumb piece 260' may be moved in a proximal direction
to decrease the pressure of the proximal volume compartment 270.
Similarly, the thumb piece 260' may be moved in a distal direction
to increase the pressure of the proximal volume compartment 270. In
some embodiments, the thumb piece 260' may be moved in either
direction by twisting the thumb piece in a clockwise direction T or
in a counterclockwise direction (not shown). In some embodiments,
adjusting the thumb piece 260' to decrease the pressure in the
proximal volume compartment 270 may decrease the difference in
pressure between the proximal volume compartment and the distal
volume compartment 265, thereby causing the force on the second
plunger 250 to decrease, which may cause a slower movement of the
second plunger in the distal direction. Similarly, in some
embodiments, adjusting the thumb piece 260' to increase the
pressure in the proximal volume compartment 270 may increase the
difference in pressure between the proximal volume compartment and
the distal volume compartment 265, thereby causing the force on the
second plunger 250 to increase, which may cause a faster movement
of the second plunger in the distal direction.
[0065] FIG. 6A depicts a side view of a syringe, generally
designated 300, having a vent 335 according to an embodiment. The
syringe 300 may generally include a syringe body 305 having a
hollow lumen 307, a proximal end 301, and a distal end 302 having a
tip 310. The syringe body 305 is not limited in shape or size by
this disclosure, and may be any shape or size, particularly shapes
and sizes of syringe bodies commonly known by those skilled in the
art. In various embodiments, the syringe body 305 may be
substantially cylindrical. In various embodiments, the syringe body
305 may be about 4 ml to about 20 ml in volume. In particular
embodiments, the volume of the syringe body 305 may be about 4 ml,
about 5 ml, about 10 ml, about 15 ml, about 20 ml, or any value or
range between any two of these values. In various embodiments, the
syringe 300 may be made of glass, a polymer, a metal, a composite,
and/or the like.
[0066] In various embodiments, the hollow lumen 307 may include a
plurality of plungers disposed therein. For example, in the present
embodiment, the hollow lumen 307 may have a first plunger 325 and a
second plunger 350. However, those skilled in the art will
recognize that more than two plungers may be used without departing
from the scope of this disclosure. In some embodiments, a vacuum
chamber 320 may be disposed within the syringe body 305 in contact
with the first plunger 325. In various embodiments, the first
plunger 325 may form a seal against the interior of the syringe
body 305 by means of a first seal 330. In some embodiments, the
first seal 330 may be a separate component from the first plunger
325, such as, for example, an added O-ring and/or the like. In
these embodiments, the first seal 330 may be fixedly attached to
the first plunger 325 by any means of attachment, including
attachment apparatuses, adhesives, and/or the like, or the first
seal may removably attached to the first plunger. In other
embodiments, the first seal 330 may be fabricated as a portion of
the first plunger 325. In some embodiments, the first seal 330 may
be associated with a distal portion of the vacuum chamber 320.
[0067] In various embodiments, the second plunger 350 may be
disposed within the first plunger 325. In some embodiments, the
second plunger 350 may be mechanically activated by a piston 355.
The second plunger 350 may be attached to the piston 355 by any
means of attachment, including, but not limited to, any number of
clips, fasteners, hooks, adhesives, and/or the like. In some
embodiments, the second plunger 350 may be molded as a portion of
the piston 355. In some embodiments, the piston 355 may at least
partially extend out of an opening of the proximal end 301 of the
syringe body 305. In some embodiments, the piston 355 may generally
extend out of the first plunger 325 through a proximal wall 340.
The opening in the proximal wall 340 may be sealed with a second
seal 345 to the piston 355. The second seal 345 may be an air-tight
seal around the shaft of the piston 355. In some embodiments, the
piston 355 may contain a bore therethrough, such as 380 in FIG. 6B
or 380' in FIG. 6C, as described in greater detail herein.
[0068] In various embodiments, a proximal portion of the piston 355
may be connected to a thumb piece 360. The thumb piece 360 may
generally provide a surface upon which a user's digits or another
device applies a force to move the piston 355 in either a distal or
proximal direction. The thumb piece 360 is depicted herein as a
generally flat surface; however, those skilled in the art will
recognize that the shape and size of the thumb piece is not limited
by this disclosure, and may include any number of rings, openings,
contoured surfaces, and/or the like without departing from the
scope of the present disclosure. Persons skilled in the art will
also note that the term `thumb piece` is not intended to be
limiting; while a thumb may be a preferred digit for manipulating
the thumb piece 360, the user may use any digit(s), body extremity
(such as heel of a hand), or object to manipulate the thumb piece
as described herein. In an illustrative example, a user may press
his/her thumb against the thumb piece 360 to effect distal movement
of the piston 355 and/or other components of the syringe 300, as
described in greater detail herein. In another illustrative
example, a user may grasp thumb piece 360 with his/her thumb and
one or more additional digits on his/her hand to proximally draw
piston 355 and/or other components the syringe 300.
[0069] Similar to the first plunger 325 described herein, in
various embodiments, the second plunger 350 may form an airtight
seal against an interior surface of the vacuum chamber 320, thereby
dividing the vacuum chamber into two volume compartments. A distal
volume compartment 365 may be created by the space between a distal
surface of the second plunger 350 and a distal end of the vacuum
chamber 320. A proximal volume compartment 370 may be created by
the space between a proximal surface of the second plunger 350 and
a distal surface of the proximal wall 340 of the vacuum chamber
320.
[0070] In various embodiments, the vacuum chamber 320 may be
detachable from the first plunger 325. The ability to detach the
vacuum chamber 320 from the first plunger 325 may allow for use of
vacuum chambers that vary in size and shape, thereby increasing
compatibility with a wide range of forces to allow for varying
pressures and flow rates, as described in greater detail
herein.
[0071] In various embodiments, the vacuum chamber 320 may include a
vent 335. The vent 335 may generally be an opening within the
vacuum chamber 320 and/or a bore through the shaft of piston 355 to
allow fluid communication of air between the proximal volume
compartment 370 and an area outside the syringe body 305. In some
embodiments, the communication between the vent 335 and the area
outside the syringe body 305 may be along a path extending through
the proximal wall 340.
[0072] In various embodiments, a fluid aspiration volume 375 may be
defined within the syringe body 305. In some embodiments, the fluid
aspiration volume 375 may be defined as the space that is located
distally to the first plunger 325. In some embodiments, the fluid
aspiration volume 375 may contain a fluid therein. Examples of
fluids are not limited by this disclosure, and may include, for
example, medications, supplements, bodily fluids, contrast media,
saline, suspensions of biological cells, and/or the like. In some
embodiments, fluid contained within the fluid aspiration volume 375
may be aspirated through the tip 310. The tip 310 may further be
configured to be connected to additional elements, such as, for
example, needles, tubes, nozzles, and/or the like for aspiration of
the fluid. It may be appreciated that the first seal 330 may be
configured to prevent air transfer from either outside the syringe
body 305 or the vacuum chamber 320 from entering the aspiration
volume 375. Similarly, the first seal 330 may be configured to
prevent air and/or fluid from escaping the aspiration volume 375
into the vacuum chamber 320 and/or the remainder of the syringe
body 305. The volume of the aspiration volume 375 may be determined
by the distance between the first plunger 325 and the distal end
302 of the syringe body 305, as well as the circumference of the
syringe body 305.
[0073] In various embodiments, one or more finger guards 315 may be
positioned at a location that is generally located at or near the
proximal end 301 of the syringe body 305. In some embodiments, the
finger guards 315 may generally be located on an outside surface of
the syringe body 305 and may generally extend from the outside
surface of the syringe body. In some embodiments, the finger guards
315 may act to provide stability to the syringe 300 during
operation. In some embodiments, a user may use the finger guards
315 to prevent movement of the syringe 300 during operation. In
some embodiments, the user may use the finger guards 315 to prevent
the syringe 300 from slipping out of the user's hand. In some
embodiments, the user may use the finger guards 315 to protect the
user's fingers. In some embodiments, the finger guards 315 may act
as a stopping device to prevent the piston 355 from moving further
distally inside the syringe body 305. The shape and size of the
finger guards 315 are not limited by this disclosure, and may be
any shape and/or size known in the art. Specific examples of shapes
may be ring shaped, wedge shaped, and/or the like.
[0074] In various embodiments, as depicted in FIGS. 6B and 6C, the
bore 380, 380' may be used in lieu of the vent 335 (FIG. 6A). In
some embodiments, the bore 380, 380' may extend through at least a
portion of the piston 355 and/or the second plunger 350. In some
embodiments, the bore 380, 380' may be configured to allow air from
outside the syringe 300 to enter and/or escape the vacuum chamber
320, such as proximal volume compartment 370, effectively
regulating by increasing and/or decreasing the pressure of air
inside the vacuum chamber 320. In some embodiments, the bore 380
may include a bore outlet 381 containing a valve and/or the like to
assist in regulation of air pressure inside the vacuum chamber 320.
In some embodiments, the valve may be incorporated within the thumb
piece 360. In other embodiments, the valve may be a separate
element, such as a one way check valve or the like. In yet other
embodiments, a user may use his/her finger to block the bore 380 in
a manner similar to that of a valve. In some embodiments, such as
the syringe shown in FIG. 6B, the bore 380 may be curved or angled
so that the bore outlet 381 is located substantially on a side of
the piston 355, such as, for example, a top side, a bottom side, or
the like. In other embodiments, such as the syringe shown in FIG.
6C, the bore 380' may be substantially straight and/or linear with
the piston 355. Such a configuration may allow for the bore outlet
381' to be located at or near the thumb piece 360. In some
embodiments with this configuration, the thumb piece 360 may act as
the valve to block the bore outlet 381', as previously described
herein. In other embodiments with this configuration, a user may
block the bore outlet 381' with an external apparatus, a thumb,
and/or the like while manipulating the thumb piece 360 at the same
time.
[0075] FIG. 7A depicts a side view of an alternative syringe,
generally designated 400, according to an embodiment. Similar to
the syringe 300 disclosed with respect to FIGS. 6A-6C above, the
syringe 400 may include a syringe body 405 having a proximal end
401 and a distal end 402. In some embodiments, the syringe body 405
may include a first plunger 425 disposed therein, the plunger
incorporating a first seal 430. An aspiration volume 475 may be
formed between the distal surface of the first plunger 425 and the
tip 410.
[0076] In various embodiments, a vacuum chamber 420 may be disposed
within the syringe body 405. In some embodiments, the vacuum
chamber 420 may be bounded by a distal wall 440 and a proximal
thumb piece 460. In some embodiments, at least a portion of the
vacuum chamber 420 may contain air that is pressurized to a
pressure at or above standard atmospheric air pressure at sea
level, as described in greater detail herein. In other embodiments,
at least a portion of the vacuum chamber 420 may contain air that
is pressurized to a pressure below standard atmospheric air
pressure at sea level (i.e., a full or partial vacuum), as
described in greater detail herein.
[0077] In various embodiments, the first plunger 425 may be
mechanically coupled via a piston 455 to a second plunger 450. The
first plunger 425 may generally be disposed at a location inside
the syringe body 405, as previously described herein, and further
disposed at a location that is distal to the vacuum chamber 420. In
some embodiments, the positioning of the first plunger 425 and the
vacuum chamber 420 may define a medial compartment 485
therebetween. Particularly, the medial compartment 485 may be
formed between the proximal surface of the first plunger 425 and
the distal surface of the distal wall 440. In some embodiments, the
piston 455 may traverse the medial compartment 485 and extend into
the vacuum chamber 420 through the distal wall 440. In some
embodiments, the piston 455 may be attached by any means of
attachment to the first plunger 425 and/or the second plunger 450.
In some embodiments, the piston 455 may be molded as a portion of
the first plunger 425 and/or the second plunger 450. In some
embodiments, the piston 455 may be detachable from the first
plunger 425 and/or the second plunger 450. The ability to detach
the piston 455 from one or both of the plungers 425, 450 may allow
for the piston to be used with varying plungers, thereby increasing
compatibility with a wide range of syringes of different sizes and
shapes, lowering operating costs, lowering manufacturing costs,
enabling the use pre-filled syringes, and/or the like.
[0078] In various embodiments, the second plunger 450 may be
located within the first plunger 425. As in the embodiments
depicted herein with respect to FIGS. 6A-6C, the second plunger 450
may be configured to form an airtight seal against an interior
surface of the vacuum chamber 420, thereby dividing the vacuum
chamber into two compartments. A distal volume compartment 465 may
be created by the space between a distal surface of the second
plunger 450 and the distal wall 440 of the vacuum chamber 420. A
proximal volume compartment 470 may be created by the space between
a proximal surface of the second plunger 450 and a distal surface
of the thumb piece 260.
[0079] In various embodiments, a second seal 445 may be positioned
within the distal wall 440 around the piston 455 to form an
airtight seal around the piston. In some embodiments, the second
seal 445 may prevent air from entering and/or escaping from the
proximal volume compartment 470 when the piston 455 is actuated. In
some embodiments, the proximal volume compartment 470 may be sealed
and/or evacuated before the syringe 400 is used.
[0080] In optional embodiments, the vacuum chamber 420 may include
a vent 435. The vent 435 may generally be an opening within the
vacuum chamber 420 configured to allow fluid communication of air
between an area outside the syringe body 405 and the distal volume
compartment 465. The vent 435 may be further configured to equalize
air pressure within the distal volume compartment 465 with the
outside air pressure through a second vent 436 extending through
the syringe body 405. In some embodiments, the outside air pressure
may be about 14.7 psi, or standard atmospheric pressure at sea
level.
[0081] As depicted in FIG. 7B, a movable thumb piece 460' may be
used instead of a vent according to some embodiments. The movable
thumb piece 460' may be moved generally distally and/or proximally
by any means of movement, and is not limited by this disclosure. By
way of example only, the movable thumb piece 460' in the present
embodiment may contain a plurality of threads 490 that allow the
thumb piece to be screwed into the vacuum chamber 420. In some
embodiments, the thumb piece 460' may be screwed over the vacuum
chamber 420. In other embodiments, the thumb piece 460' may be
screwed inside the vacuum chamber 420. The thumb piece 460' may be
screwed into a specific depth to obtain a desired pressure inside
the distal volume compartment 465, as will be described in greater
detail herein. To aid in determining the pressure inside the distal
volume compartment 465, a guide 495 may be located on the syringe
400 to aid a user in determining where to position the thumb piece
460'. For example, the guide 495 may be a plurality of indicia,
such as hash marks, printed on an outside surface of the vacuum
chamber 420, wherein each hash mark is labeled with the vacuum that
will be achieved during aspiration by moving the thumb piece 460'
to that hash mark. In some embodiments, the thumb piece 460 may
incorporate a display that indicates the amount of adjusted vacuum
inside the proximal volume chamber 470.
[0082] In various embodiments, the syringe 400 may further include
any number of shock absorbing devices 500. Specific examples of
shock absorbing devices 500 may include, for example, springs, air
cushions, absorbing materials, and/or the like. The shock absorbing
devices 500 may generally function to ensure a smooth distribution
of fluid out of the tip 410 at a constant rate that acts
supplementary to the driving force cause by the difference in
pressure, as described in greater detail herein. According to
various embodiments, such as illustrated in FIGS. 7A-7B, piston 455
may further include one or more indicator markings 505, such as
hash marks or rings, on the shaft located within medial compartment
485. The indicator markings 505 may allow a user to know when the
draw force on shock absorbing device 500, and therefore the rate at
which the first plunger 425 is withdrawn, exceeds a critical
infusion rate. Examples of critical infusion rates may correspond
to, for example, the maximum reduced pressure that certain
biological cells can withstand before lysing. Thus, for example,
the user may proximally withdraw thumb piece 460' while monitoring
the reduced pressure within aspiration volume 475 by observing the
indicator markings 505 to ensure that the reduced pressure does not
exceed the pressure at which the biological cells may lyse.
[0083] FIGS. 8A-8B depict movement of the various components of the
syringe 300 depicted in FIGS. 6A-6C according to an embodiment
during an aspiration process. More particularly, FIG. 8A depicts an
initial state of the syringe 300. As previously described herein, a
force F may be applied to the thumb piece 360 to force the piston
355 in a proximal direction away from the syringe body 305. As a
result, the piston 355 may mechanically force the second plunger
350 to move in a proximal direction within the vacuum chamber
320.
[0084] As described in greater detail herein, the movement of the
second plunger 350 in a proximal direction may increase the volume
of the distal volume compartment 365 while decreasing the volume of
the proximal volume compartment 370. In some instances, this
combination may result in a decrease in pressure in the distal
volume compartment 365 where the distal volume compartment 365 has
a pressure greater than or equal to zero. However, in instances
where the distal volume compartment 365 is a vacuum (thereby having
a zero pressure), this combination will not change the pressure
within the distal volume compartment 365. This is due to the ideal
gas law, which is represented by Equation (1):
PV=nRT (1)
where P is the pressure of the gas, V is the volume of the gas, n
is the amount of substance of gas (also known as number of moles),
T is the temperature of the gas and R is the ideal, or universal,
gas constant, equal to the product of the Boltzmann constant and
the Avogadro constant. To compare different volumes, Equation (1)
can be written to reflect the different volumes as follows:
P.sub.1V.sub.1=nR.sub.1T.sub.1 and P.sub.2V.sub.2=nR.sub.2T.sub.2.
If P.sub.1 and P.sub.2 are both zero because of the vacuum (zero
pressure), then a change in either volume V.sub.1, V.sub.2 won't
change the results.
[0085] Furthermore, the pressure can be written as a function of
force, as represented by Equation (2):
.DELTA.P=F/A (2)
where .DELTA.P is the change in pressure, F is the normal force,
and A is the area of the surface on contact. Thus, in an
illustrative example, if the pressure P is zero (0 psi), such as in
a vacuum, then according to Equation (1), the pressure will not
change when other variables change, such as, for example, the
volume V. Since the pressure remains the same, the force F that is
exerted by the pressure will also remain constant according to
Equation (2), which allows for a smooth aspiration of the fluid
into the aspiration volume 375.
[0086] Similarly, the movement of the second plunger 350 in a
proximal direction may decrease the volume of the proximal volume
compartment 370. However, due to the location of the vent 335 (or
in some embodiments, the bore 380), the pressure of the proximal
volume compartment 370 may equalize with the outside air pressure
(i.e., moving towards about 14.7 psi). As a result the force F may
be active on the second plunger 350 due to the unequal pressure
between the pressure of the distal volume compartment 365 and the
pressure of the proximal volume compartment 370. In some
embodiments, the pressure of the proximal volume compartment 370
may be greater than the pressure of the distal volume compartment
365. In other embodiments, such as those where it is desired to
expel fluid from the syringe 300, the pressure of the proximal
volume compartment 370 may be less than the pressure of the distal
volume compartment 365. In some embodiments, to ensure that the
proximal volume compartment has a higher pressure than the distal
volume compartment 365, the distal volume compartment 365 may be
pre-evacuated prior to movement of the piston 355. The
pre-evacuation process may be completed, for example, by attaching
a vacuum pump or the like to the distal volume compartment 365
through a sealable valve and port (not shown). According to these
embodiments, the second plunger 350 may be located adjacent to the
inner distal wall of vacuum chamber 320.
[0087] In various embodiments, because of the unequal pressure
between the distal volume compartment 365 and the proximal volume
compartment 370, a driving force F' may be active on the vacuum
chamber 320. However, since the user may maintain force on the
thumb piece 360 to keep it in a withdrawn state, the second plunger
350 may be fixed relative to the syringe body 305. Accordingly, the
pressure difference between the distal volume compartment 365 and
the proximal volume compartment 370 may force the vacuum chamber
320 to shift in the proximal direction, thereby driving the first
plunger 325 in a proximal direction toward the proximal end 301 of
the syringe body 305. The resulting motion of the first plunger 325
may increase the aspiration volume 375, causing the fluid to be
aspirated into the aspiration volume 325 through the tip 310 at a
steady rate. Those skilled in the art may appreciate that the
driving force F' on the first plunger 325 may be due to the
pressure difference developed between the proximal volume
compartment 370 and the distal volume compartment 365, and may not
depend on the user's force on the thumb piece 360. Those skilled in
the art may also appreciate that the driving force F' on the first
plunger 325 may not be due to the position of the second plunger
350 relative to the vacuum chamber 320 and/or the syringe body 305,
as long as the second plunger is not located at the proximal end
301 or the distal end 302 of the syringe body 305. Furthermore, the
driving force F' on the first plunger 325 may not be due to the
velocity of the second plunger 350 in moving towards the proximal
end 301 of the syringe body 305 provided that there is only a small
amount of friction between the second plunger and the vacuum
chamber 320. Accordingly, the rate of motion of the first plunger
325 may be smooth and constant since the force on the first plunger
350 is determined by the pressure differential between the distal
and proximal compartments of vacuum chamber 329 and not on the rate
at which the second plunger is withdrawn, and thus may not reflect
any possible unsteady movement from the user. Furthermore, the rate
of aspiration of the fluid into the aspiration volume 375 may be
adjusted by the user prior to applying force on the thumb piece 360
by increasing or decreasing the pressure of the proximal volume
compartment 370, as described in greater detail herein.
[0088] FIGS. 9A-9C depict the effect on the syringe of FIG. 7A when
a force F is applied to the thumb piece 460 according to various
embodiments. In some embodiments, the force F may cause the thumb
piece 460 to move in a generally proximal direction. This movement
of the thumb piece 460 may cause the vacuum chamber 420 to also
travel in a generally proximal direction within the syringe body
405. In some embodiments, the various volume compartments 465, 470
may change volume as a result of the movement while the pressure
remains the same (i.e., about 14.7 psi in the distal volume
compartment 465 and substantially zero psi in the proximal volume
compartment 470), as previously described herein. In some
embodiments, the force F applied to the thumb piece 460 may cause
the vacuum chamber 420 to move relative to the second plunger 450.
The movement of the vacuum chamber 420 may therefore result in an
increase in the volume of the proximal volume compartment 470 and a
decrease in volume of the distal volume compartment 465. In various
embodiments, a driving force F' that pulls the first plunger 425
towards the proximal end 401 of the syringe body 405 may result
from the difference of pressure of the distal volume compartment
465 (where the pressure is at or near atmospheric pressure, or
about 14.7 psi) and the proximal volume compartment 470 (where the
pressure is zero psi) as described herein. Accordingly, if a user
of the syringe 400 provides a sharp force on the thumb piece 460 in
the proximal direction, it will have no effect on the rate of
aspiration of fluid through the tip 410 because the difference in
pressures in the distal volume compartment 465 and the proximal
volume compartment 470 will continue to remain the same, even with
the proximal volume compartment 470 increasing in volume. In
addition, if a faster rate of aspiration of fluid through the tip
410 is desired, the vent 435 and/or 436 can be covered with a valve
or a user's finger while a force is exacted upon the thumb piece
460 to increase the pressure of the distal volume compartment 470
and alter the driving force F' accordingly. After a desired volume
of fluid is aspirated into the aspiration volume 475, the syringe
400 is ready for fluid delivery. The fluid delivery may be effected
by driving the thumb piece 460 in a distal direction such that the
proximal volume compartment 470 is reduced in volume relative to
the distal volume compartment 465 and the fluid is expelled through
the tip 410.
[0089] FIGS. 10A-10C depict the effect on the syringe of FIG. 7B
when a force F is applied to the thumb piece 460' according to
various embodiments. The movement of the various components of the
syringe 400 is substantially the same as previously described
herein with respect to FIGS. 9A-9C; however, instead of regulating
the pressure of the distal volume compartment 465 with a vent to
increase the rate of distribution of fluid, distal volume
compartment 465 contains a gas and is sealed to the atmosphere; and
the thumb piece 460' may be moved to adjust the volume and the
pressure of the distal volume compartment 465. For example, the
thumb piece 460' may have a rod extending in the distal direction
that contacts the second plunger 450 and urges the second plunger
in the proximal or distal direction depending on the position of
the thumb piece 460'. For example, the thumb piece 460' may be
moved in a proximal direction relative to the vacuum chamber 420 to
decrease the pressure of the distal volume compartment 465. Because
the distal volume compartment 465 is at a higher pressure relative
to the proximal volume compartment 470, the second plunger 450 will
move in a proximal direction with the movement of the thumb piece
460'. For example, thumb piece 460' may be connected to vacuum
chamber 420 by a threaded mechanism where the distal/proximal
position of thumb piece 460' may be adjusted. In some embodiments,
the thumb piece 460' may be moved in either a proximal or a distal
direction by twisting the thumb piece 460' in a clockwise direction
T (FIG. 10B) or in a counterclockwise direction (not shown). In
some embodiments, adjusting the thumb piece 460' to decrease the
pressure in the distal volume compartment 465 may decrease the
difference in pressure between the proximal volume compartment 470
and the distal volume compartment 465, thereby causing the force on
the second plunger 450 to decrease, which may cause a slower but
uniform movement of the first plunger 425 in the proximal
direction. Similarly, in some embodiments, adjusting the thumb
piece 460' move the second plunger 450 in a distal direction will
increase the pressure in the distal volume compartment 465 and may
increase the difference in pressure between the proximal volume
compartment 470 and the distal volume compartment 465. The force on
the second plunger 450 increases correspondingly, which may cause a
faster but uniform movement of the first plunger 425 in the
proximal direction.
[0090] In another embodiment, the thumb piece 460' may be sealed to
the vacuum chamber 420 and may comprise a threaded rod, or an
equivalent connection means, extending through thumb piece 460' and
contacting second plunger 450, where the proximal end of the
threaded rod has means to rotate the threaded rod in a clockwise or
counter-clockwise direction thereby moving the distal end of
threaded rod in a distal or proximal direction. In this manner, the
distal or proximal movement of the threaded rod results in a
corresponding distal or proximal movement of the second plunger 450
relative to the vacuum chamber 420 by turning threaded rod in a
clockwise or counter-clockwise direction to force second plunger
450 in a distal or proximal direction. The distal volume
compartment 465 may contain a gas such that movement of the
threaded rod and the second plunger 450 adjusts the volume and the
pressure of the distal volume compartment 465. Because the distal
volume compartment 465 is at a higher pressure relative to the
proximal volume compartment 470, the second plunger 450 will move
in a proximal direction when the force provided by threaded rod to
the second plunger is lessened, for example by rotating threaded
rod in a counter-clockwise direction. Adjusting the thumb piece
460' to decrease the pressure in the distal volume compartment 465
may decrease the difference in pressure between the proximal volume
compartment 470 and the distal volume compartment 465, thereby
causing the force on the second plunger 450 to decrease, which may
cause a slower but uniform movement of the first plunger 425 in the
proximal direction. Similarly, in some embodiments, adjusting the
threaded rod to move the second plunger 450 in a distal direction,
for example by rotating in a clockwise direction, will increase the
pressure in the distal volume compartment 465 and may increase the
difference in pressure between the proximal volume compartment 470
and the distal volume compartment 465. The force on the second
plunger 450 increases correspondingly, which may cause a faster but
uniform movement of the first plunger 425 in the proximal
direction. It will be understood that the rotation direction of
thumb piece 460' or threaded rod may be reversed by reversing the
direction of the threads in either the vacuum chamber 420 or thumb
piece 460'.
[0091] Although various embodiments have been described in detail
for the purpose of illustration, it is to be understood that such
detail is solely for that purpose and that the disclosure is not
limited to the disclosed embodiments, but, on the contrary, is
intended to cover modifications and equivalent arrangements. For
example, it is to be understood that this disclosure contemplates
that, to the extent possible, one or more features of any
embodiment can be combined with one or more features of any other
embodiment.
* * * * *