U.S. patent application number 14/837448 was filed with the patent office on 2016-01-21 for reagents and methods for modulating cone photoreceptor activity. The applicant listed for this patent is William W. HAUSWIRTH, James A. KUCHENBECKER, Jay NEITZ, Maureen NEITZ. Invention is credited to William W. HAUSWIRTH, James A. KUCHENBECKER, Jay NEITZ, Maureen NEITZ.
Application Number | 20160015288 14/837448 |
Document ID | / |
Family ID | 42989381 |
Filed Date | 2016-01-21 |
United States Patent Application | 20160015288 |
Kind Code | A1 |
NEITZ; Jay ; et al. | January 21, 2016 |
The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.
Inventors: | NEITZ; Jay; (Seattle, WA) ; NEITZ; Maureen; (Seattle, WA) ; KUCHENBECKER; James A.; (Seattle, WA) ; HAUSWIRTH; William W.; (Gainesville, FL) | ||||||||||
Applicant: |
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Family ID: | 42989381 | ||||||||||
Appl. No.: | 14/837448 | ||||||||||
Filed: | August 27, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14075415 | Nov 8, 2013 | 9198595 | ||
14837448 | ||||
13395609 | Mar 12, 2012 | |||
PCT/US2010/048964 | Sep 15, 2010 | |||
14075415 | ||||
61242587 | Sep 15, 2009 | |||
Current U.S. Class: | 424/93.2 ; 435/320.1; 435/363; 514/44R; 600/383 |
Current CPC Class: | A61B 5/6821 20130101; C12N 2830/008 20130101; C12N 2750/14143 20130101; A61B 5/4848 20130101; A61B 5/4836 20130101; A61N 2005/0652 20130101; C07K 14/005 20130101; A61B 5/0036 20180801; A61N 5/0622 20130101; C12N 2799/025 20130101; A61B 5/0048 20130101; A61P 27/02 20180101; C12N 15/85 20130101; A61K 48/0058 20130101; A61K 48/0075 20130101; C12N 15/86 20130101; C12N 2830/42 20130101; A61B 5/7225 20130101; A61N 2005/0661 20130101; C12N 7/00 20130101; C12N 2750/14132 20130101; C12N 2840/44 20130101; A61N 2005/0663 20130101; A61B 5/0496 20130101 |
International Class: | A61B 5/0496 20060101 A61B005/0496; A61B 5/00 20060101 A61B005/00; C12N 7/00 20060101 C12N007/00; A61K 48/00 20060101 A61K048/00; C12N 15/86 20060101 C12N015/86; C07K 14/005 20060101 C07K014/005 |
Sequence CWU 1
1
511494DNAArtificial SequenceSynthetic 1ggatccggtt ccaggcctcg
gccctaaata gtctccctgg gctttcaaga gaaccacatg 60agaaaggagg attcgggctc
tgagcagttt caccacccac cccccagtct gcaaatcctg 120acccgtgggt
ccacctgccc caaaggcgga cgcaggacag tagaagggaa cagagaacac
180ataaacacag agagggccac agcggctccc acagtcaccg ccaccttcct
ggcggggatg 240ggtggggcgt ctgagtttgg ttcccagcaa atccctctga
gccgcccttg cgggctcgcc 300tcaggagcag gggagcaaga ggtgggagga
ggaggtctaa gtcccaggcc caattaagag 360atcaggtagt gtagggtttg
ggagctttta aggtgaagag gcccgggctg atcccacagg 420ccagtataaa
gcgccgtgac cctcaggtga tgcgccaggg ccggctgccg tcggggacag
480ggctttccat agcc 4942494DNAArtificial SequenceSynthetic
2ttatttagta gaaacggggt ttcaccatgt tagtcaggct ggtcgggaac tcctgacctc
60aggagatcta cccgccttgg cctcccaaag tgctgggatt acaggcgtgt gccactgtgc
120ccagccactt ttttttagac agagtcttgg tctgttgccc aggctagagt
tcagtggcgc 180catctcagct cactgcaacc tccgcctccc agattcaagc
gattctcctg cctcgacctc 240ccagtagctg ggattacagg tttccagcaa
atccctctga gccgcccccg ggggctcgcc 300tcaggagcaa ggaagcaagg
ggtgggagga ggaggtctaa gtcccaggcc caattaagag 360atcagatggt
gtaggatttg ggagctttta aggtgaagag gcccgggctg atcccactgg
420ccggtataaa gcaccgtgac cctcaggtga cgcaccaggg ccggctgccg
tcggggacag 480ggctttccat agcc 4943568DNAArtificial
SequenceSynthetic 3ctaggcattg tcaagttgcc taagtcctgt tccatcaagg
ctgtttactg atgtgcttcc 60agggcactcc ccactcccag ccctttcctg cagcccaggg
ctggttccta gcctctcagc 120agacttaaga tgggcacctt ccacaaaggg
gcagatgagt tgaggaaaac ttaactgata 180cagttgtgcc agaagccaaa
ataagaggcg tgccctttct atagccccat taaaagaaca 240aaaaagtgga
agcatcttca gtgaatatgg gtcagcacct cccagacctc agggagtcca
300cttctgttca tcccagcacc cagcattgca tatccagatt atttgagccc
aatctcttat 360cctctgaaga acacaatcgg ctttggggcc acaaaaggtt
taggtagtgg tttagggatt 420tctaatccca aactttgtcc ttgggaggtt
taggattagt attgatcatt cacagagccc 480aagtgttttt agaggagggg
ttttgtgggg tgggaggatc acctataaga ggactcagag 540gggggtgtgg
ggcatccatg agaaaaat 56841555DNAArtificial SequenceSynthetic
4ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt agggggcctt
60ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg cgtttacgga
120cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat
gtttaaccac 180acaaaaatga aaatccaatg gttggatatc cattccaaat
acacaaaggc aacggataag 240tgatccgggc caggcacaga aggccatgca
cccgtaggat tgcactcaga gctcccaaat 300gcataggaat agaagggtgg
gtgcaggagg ctgaggggtg gggaaagggc atgggtgttt 360catgaggaca
gagcttccgt ttcatgcaat gaaaagagtt tggagacgga tggtggtgac
420tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat
attttaccac 480gatcttttta aagtgtcaaa ggcaaatggc caaatggttc
cttgtcctat agctgtagca 540gccatcggct gttagtgaca aagcccctga
gtcaagatga cagcagcccc cataactcct 600aatcggctct cccgcgtgga
gtcatttagg agtagtcgca ttagagacaa gtccaacatc 660taatcttcca
ccctggccag ggccccagct ggcagcgagg gtgggagact ccgggcagag
720cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt
tccccagggg 780ccctctttcc ttggggcttt cttgggccgc cactgctccc
gctcctctcc ccccatccca 840ccccctcacc ccctcgttct tcatatcctt
ctctagtgct ccctccactt tcatccaccc 900ttctgcaaga gtgtgggacc
acaaatgagt tttcacctgg cctggggaca cacgtgcccc 960cacaggtgct
gagtgacttt ctaggacagt aatctgcttt aggctaaaat gggacttgat
1020cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac
ctaccgcctt 1080tccaggcctc ctcccacctc tgccacctcc actctccttc
ctgggatgtg ggggctggca 1140cacgtgtggc ccagggcatt ggtgggattg
cactgagctg ggtcattagc gtaatcctgg 1200acaagggcag acagggcgag
cggagggcca gctccggggc tcaggcaagg ctgggggctt 1260cccccagaca
ccccactcct cctctgctgg acccccactt catagggcac ttcgtgttct
1320caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca
gagttgctta 1380tctccctcta gacagaaggg gaatctcggt caagagggag
aggtcgccct gttcaaggcc 1440acccagccag ctcatggcgg taatgggaca
aggctggcca gccatcccac cctcagaagg 1500gacccggtgg ggcaggtgat
ctcagaggag gctcacttct gggtctcaca ttctt 15555189DNAArtificial
SequenceSynthetic 5gatccggtac tcgaggaact gaaaaaccag aaagttaact
ggtaagttta gtctttttgt 60cttttatttc aggtcccgga tccggtggtg gtgcaaatca
aagaactgct cctcagtgga 120tgttgccttt acttctaggc ctgtacggaa
gtgttacttc tgctctaaaa gctgcggaat 180tgtacccgc 18961114DNAHomo
sapiens 6atgagaaaaa tgtcggagga agagttttat ctgttcaaaa atatctcttc
agtggggccg 60tgggatgggc ctcagtacca cattgcccct gtctgggcct tctacctcca
ggcagctttc 120atgggcactg tcttccttat agggttccca ctcaatgcca
tggtgctggt ggccacactg 180cgctacaaaa agttgcggca gcccctcaac
tacattctgg tcaacgtgtc cttcggaggc 240ttcctcctct gcatcttctc
tgtcttccct gtcttcgtcg ccagctgtaa cggatacttc 300gtcttcggtc
gccatgtttg tgctttggag ggcttcctgg gcactgtagc aggtctggtt
360acaggatggt cactggcctt cctggccttt gagcgctaca ttgtcatctg
taagcccttc 420ggcaacttcc gcttcagctc caagcatgca ctgacggtgg
tcctggctac ctggaccatt 480ggtattggcg tctccatccc acccttcttt
ggctggagcc ggttcatccc tgagggcctg 540cagtgttcct gtggccctga
ctggtacacc gtgggcacca aataccgcag cgagtcctat 600acgtggttcc
tcttcatctt ctgcttcatt gtgcctctct ccctcatctg cttctcctac
660actcagctgc tgagggccct gaaagctgtt gcagctcagc agcaggagtc
agctacgacc 720cagaaggctg aacgggaggt gagccgcatg gtggttgtga
tggtaggatc cttctgtgtc 780tgctacgtgc cctacgcggc cttcgccatg
tacatggtca acaaccgtaa ccatgggctg 840gacttacggc ttgtcaccat
tccttcattc ttctccaaga gtgcttgcat ctacaatccc 900atcatctact
gcttcatgaa taagcagttc caagcttgca tcatgaagat ggtgtgtggg
960aaggccatga cagatgaatc cgacacatgc agctcccaga aaacagaagt
ttctactgtc 1020tcgtctaccc aagttggccc caactgagga cccaatattg
gcctgtttgc aacagctaga 1080attaaatttt acttttaaaa aaaaaaaaaa aaaa
11147348PRTHomo sapiens 7Met Arg Lys Met Ser Glu Glu Glu Phe Tyr
Leu Phe Lys Asn Ile Ser 1 5 10 15 Ser Val Gly Pro Trp Asp Gly Pro
Gln Tyr His Ile Ala Pro Val Trp 20 25 30 Ala Phe Tyr Leu Gln Ala
Ala Phe Met Gly Thr Val Phe Leu Ile Gly 35 40 45 Phe Pro Leu Asn
Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 50 55 60 Leu Arg
Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 65 70 75 80
Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 85
90 95 Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly
Phe 100 105 110 Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu
Ala Phe Leu 115 120 125 Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro
Phe Gly Asn Phe Arg 130 135 140 Phe Ser Ser Lys His Ala Leu Thr Val
Val Leu Ala Thr Trp Thr Ile 145 150 155 160 Gly Ile Gly Val Ser Ile
Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 165 170 175 Pro Glu Gly Leu
Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 180 185 190 Thr Lys
Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 195 200 205
Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 210
215 220 Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr
Thr 225 230 235 240 Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val
Val Met Val Gly 245 250 255 Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala
Ala Phe Ala Met Tyr Met 260 265 270 Val Asn Asn Arg Asn His Gly Leu
Asp Leu Arg Leu Val Thr Ile Pro 275 280 285 Ser Phe Phe Ser Lys Ser
Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 290 295 300 Phe Met Asn Lys
Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 305 310 315 320 Lys
Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 325 330
335 Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 340 345
81998DNAHomo sapiens 8cccactggcc ggtataaagc accgtgaccc tcaggtgacg
caccagggcc ggctgccgtc 60ggggacaggg ctttccatag ccatggccca gcagtggagc
ctccaaaggc tcgcaggccg 120ccatccgcag gacagctatg aggacagcac
ccagtccagc atcttcacct acaccaacag 180caactccacc agaggcccct
tcgaaggccc gaattaccac atcgctccca gatgggtgta 240ccacctcacc
agtgtctgga tgatctttgt ggtcattgca tccgtcttca caaatgggct
300tgtgctggcg gccaccatga agttcaagaa gctgcgccac ccgctgaact
ggatcctggt 360gaacctggcg gtcgctgacc tggcagagac cgtcatcgcc
agcactatca gcgttgtgaa 420ccaggtctat ggctacttcg tgctgggcca
ccctatgtgt gtcctggagg gctacaccgt 480ctccctgtgt gggatcacag
gtctctggtc tctggccatc atttcctggg agagatggat 540ggtggtctgc
aagccctttg gcaatgtgag atttgatgcc aagctggcca tcgtgggcat
600tgccttctcc tggatctggg ctgctgtgtg gacagccccg cccatctttg
gttggagcag 660gtactggccc cacggcctga agacttcatg cggcccagac
gtgttcagcg gcagctcgta 720ccccggggtg cagtcttaca tgattgtcct
catggtcacc tgctgcatca ccccactcag 780catcatcgtg ctctgctacc
tccaagtgtg gctggccatc cgagcggtgg caaagcagca 840gaaagagtct
gaatccaccc agaaggcaga gaaggaagtg acgcgcatgg tggtggtgat
900ggtcctggca ttctgcttct gctggggacc atacgccttc ttcgcatgct
ttgctgctgc 960caaccctggc taccccttcc accctttgat ggctgccctg
ccggccttct ttgccaaaag 1020tgccactatc tacaaccccg ttatctatgt
ctttatgaac cggcagtttc gaaactgcat 1080cttgcagctt ttcgggaaga
aggttgacga tggctctgaa ctctccagcg cctccaaaac 1140ggaggtctca
tctgtgtcct cggtatcgcc tgcatgaggt ctgcctccta cccatcccgc
1200ccaccggggc tttggccacc tctcctttcc ccctccttct ccatccctgt
aaaataaatg 1260taatttatct ttgccaaaac caacaaagtc acagaggctt
tcactgcagt gtgggaccac 1320ctgagcctct gcgtgtgcag gcactgggtc
tcgagagggt gcaaggggga taaagaggag 1380agagcgcttc atagacttta
agttttcccg agcctcatgt ctaccgatgg cgtgaaagga 1440tcctggcaaa
acagaagtgt gaggcaggtg ggcgtctata tccatttcac caggctggtg
1500gttacataat cggcaagcaa gagctgtgga ggggcttgct ggatgccctc
agcacccagg 1560aggagggagg gagctagcaa gctaaggcag gtggccctcc
tggcccctta aggtccatct 1620gctggaggcc cagagtcctt ggagtacagt
ctacacctgg aggggaccca ttcctgccag 1680tctgtggcag ggatggcgcg
ccacctctgc caggccagga ccccaagccc gatcagcatc 1740agcatggtgc
aggtgcacag gcgtgagctg atcagtgacg aggggcaggc acacaaggtg
1800gagacaaaga ccaagaggac ggttgccagt gagaggcgcg gactcaggaa
cttgaacaac 1860atctgcgggg gacggctttg gaggtgctcc gctgcctcca
gttgggtgac ttgctgtagc 1920atctccagct tggatattcg gctcttgaag
gtctccgtga tctcctgcag gagacgaaaa 1980tgcacgcacc agaagtca
19989364PRTHomo sapiens 9Met Ala Gln Gln Trp Ser Leu Gln Arg Leu
Ala Gly Arg His Pro Gln 1 5 10 15 Asp Ser Tyr Glu Asp Ser Thr Gln
Ser Ser Ile Phe Thr Tyr Thr Asn 20 25 30 Ser Asn Ser Thr Arg Gly
Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 35 40 45 Pro Arg Trp Val
Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 50 55 60 Ile Ala
Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 65 70 75 80
Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 85
90 95 Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val
Val 100 105 110 Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met
Cys Val Leu 115 120 125 Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr
Gly Leu Trp Ser Leu 130 135 140 Ala Ile Ile Ser Trp Glu Arg Trp Met
Val Val Cys Lys Pro Phe Gly 145 150 155 160 Asn Val Arg Phe Asp Ala
Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 165 170 175 Trp Ile Trp Ala
Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 180 185 190 Arg Tyr
Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 195 200 205
Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 210
215 220 Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr
Leu 225 230 235 240 Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln
Gln Lys Glu Ser 245 250 255 Glu Ser Thr Gln Lys Ala Glu Lys Glu Val
Thr Arg Met Val Val Val 260 265 270 Met Val Leu Ala Phe Cys Phe Cys
Trp Gly Pro Tyr Ala Phe Phe Ala 275 280 285 Cys Phe Ala Ala Ala Asn
Pro Gly Tyr Pro Phe His Pro Leu Met Ala 290 295 300 Ala Leu Pro Ala
Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 305 310 315 320 Ile
Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 325 330
335 Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys
340 345 350 Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 355 360
101234DNAHomo sapiens 10cggctgccgt cggggacagg gctttccata gccatggccc
agcagtggag cctccaaagg 60ctcgcaggcc gccatccgca ggacagctat gaggacagca
cccagtccag catcttcacc 120tacaccaaca gcaactccac cagaggcccc
ttcgaaggcc cgaattacca catcgctccc 180agatgggtgt accacctcac
cagtgtctgg atgatctttg tggtcactgc atccgtcttc 240acaaatgggc
ttgtgctggc ggccaccatg aagttcaaga agctgcgcca cccgctgaac
300tggatcctgg tgaacctggc ggtcgctgac ctagcagaga ccgtcatcgc
cagcactatc 360agcattgtga accaggtctc tggctacttc gtgctgggcc
accctatgtg tgtcctggag 420ggctacaccg tctccctgtg tgggatcaca
ggtctctggt ctctggccat catttcctgg 480gagaggtggc tggtggtgtg
caagcccttt ggcaatgtga gatttgatgc caagctggcc 540atcgtgggca
ttgccttctc ctggatctgg tctgctgtgt ggacagcccc gcccatcttt
600ggttggagca ggtactggcc ccacggcctg aagacttcat gcggcccaga
cgtgttcagc 660ggcagctcgt accccggggt gcagtcttac atgattgtcc
tcatggtcac ctgctgcatc 720atcccactcg ctatcatcat gctctgctac
ctccaagtgt ggctggccat ccgagcggtg 780gcaaagcagc agaaagagtc
tgaatccacc cagaaggcag agaaggaagt gacgcgcatg 840gtggtggtga
tgatctttgc gtactgcgtc tgctggggac cctacacctt cttcgcatgc
900tttgctgctg ccaaccctgg ttacgccttc caccctttga tggctgccct
gccggcctac 960tttgccaaaa gtgccactat ctacaacccc gttatctatg
tctttatgaa ccggcagttt 1020cgaaactgca tcttgcagct tttcgggaag
aaggttgacg atggctctga actctccagc 1080gcctccaaaa cggaggtctc
atctgtgtcc tcggtatcgc ctgcatgagg tctgcctcct 1140acccatcccg
cccaccgggg ctttggccac ctctcctttc cccctccttc tccatccctg
1200taaaataaat gtaatttatc tttgccaaaa ccaa 123411364PRTHomo sapiens
11Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 1
5 10 15 Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr
Asn 20 25 30 Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr
His Ile Ala 35 40 45 Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp
Met Ile Phe Val Val 50 55 60 Thr Ala Ser Val Phe Thr Asn Gly Leu
Val Leu Ala Ala Thr Met Lys 65 70 75 80 Phe Lys Lys Leu Arg His Pro
Leu Asn Trp Ile Leu Val Asn Leu Ala 85 90 95 Val Ala Asp Leu Ala
Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 100 105 110 Asn Gln Val
Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 115 120 125 Glu
Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 130 135
140 Ala Ile Ile Ser Trp Glu Arg Trp Leu Val Val Cys Lys Pro Phe Gly
145 150 155 160 Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile
Ala Phe Ser 165 170 175 Trp Ile Trp Ser Ala Val Trp Thr Ala Pro Pro
Ile Phe Gly Trp Ser 180 185 190 Arg Tyr Trp Pro His Gly Leu Lys Thr
Ser Cys Gly Pro Asp Val Phe 195 200 205 Ser Gly Ser Ser Tyr Pro Gly
Val Gln Ser Tyr Met Ile Val Leu Met 210 215 220 Val Thr Cys Cys Ile
Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 225 230 235 240 Gln Val
Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 245 250 255
Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 260
265 270 Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe
Ala 275 280 285 Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro
Leu Met Ala 290 295 300 Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr
Ile Tyr Asn Pro Val 305 310 315 320 Ile Tyr Val Phe Met Asn Arg Gln
Phe Arg Asn Cys Ile Leu Gln Leu 325 330 335 Phe Gly Lys Lys Val Asp
Asp Gly Ser
Glu Leu Ser Ser Ala Ser Lys 340 345 350 Thr Glu Val Ser Ser Val Ser
Ser Val Ser Pro Ala 355 360 127326DNAHomo sapiens 12aggacacagc
gtccggagcc agaggcgctc ttaacggcgt ttatgtcctt tgctgtctga 60ggggcctcag
ctctgaccaa tctggtcttc gtgtggtcat tagcatgggc ttcgtgagac
120agatacagct tttgctctgg aagaactgga ccctgcggaa aaggcaaaag
attcgctttg 180tggtggaact cgtgtggcct ttatctttat ttctggtctt
gatctggtta aggaatgcca 240acccgctcta cagccatcat gaatgccatt
tccccaacaa ggcgatgccc tcagcaggaa 300tgctgccgtg gctccagggg
atcttctgca atgtgaacaa tccctgtttt caaagcccca 360ccccaggaga
atctcctgga attgtgtcaa actataacaa ctccatcttg gcaagggtat
420atcgagattt tcaagaactc ctcatgaatg caccagagag ccagcacctt
ggccgtattt 480ggacagagct acacatcttg tcccaattca tggacaccct
ccggactcac ccggagagaa 540ttgcaggaag aggaatacga ataagggata
tcttgaaaga tgaagaaaca ctgacactat 600ttctcattaa aaacatcggc
ctgtctgact cagtggtcta ccttctgatc aactctcaag 660tccgtccaga
gcagttcgct catggagtcc cggacctggc gctgaaggac atcgcctgca
720gcgaggccct cctggagcgc ttcatcatct tcagccagag acgcggggca
aagacggtgc 780gctatgccct gtgctccctc tcccagggca ccctacagtg
gatagaagac actctgtatg 840ccaacgtgga cttcttcaag ctcttccgtg
tgcttcccac actcctagac agccgttctc 900aaggtatcaa tctgagatct
tggggaggaa tattatctga tatgtcacca agaattcaag 960agtttatcca
tcggccgagt atgcaggact tgctgtgggt gaccaggccc ctcatgcaga
1020atggtggtcc agagaccttt acaaagctga tgggcatcct gtctgacctc
ctgtgtggct 1080accccgaggg aggtggctct cgggtgctct ccttcaactg
gtatgaagac aataactata 1140aggcctttct ggggattgac tccacaagga
aggatcctat ctattcttat gacagaagaa 1200caacatcctt ttgtaatgca
ttgatccaga gcctggagtc aaatccttta accaaaatcg 1260cttggagggc
ggcaaagcct ttgctgatgg gaaaaatcct gtacactcct gattcacctg
1320cagcacgaag gatactgaag aatgccaact caacttttga agaactggaa
cacgttagga 1380agttggtcaa agcctgggaa gaagtagggc cccagatctg
gtacttcttt gacaacagca 1440cacagatgaa catgatcaga gataccctgg
ggaacccaac agtaaaagac tttttgaata 1500ggcagcttgg tgaagaaggt
attactgctg aagccatcct aaacttcctc tacaagggcc 1560ctcgggaaag
ccaggctgac gacatggcca acttcgactg gagggacata tttaacatca
1620ctgatcgcac cctccgcctg gtcaatcaat acctggagtg cttggtcctg
gataagtttg 1680aaagctacaa tgatgaaact cagctcaccc aacgtgccct
ctctctactg gaggaaaaca 1740tgttctgggc cggagtggta ttccctgaca
tgtatccctg gaccagctct ctaccacccc 1800acgtgaagta taagatccga
atggacatag acgtggtgga gaaaaccaat aagattaaag 1860acaggtattg
ggattctggt cccagagctg atcccgtgga agatttccgg tacatctggg
1920gcgggtttgc ctatctgcag gacatggttg aacaggggat cacaaggagc
caggtgcagg 1980cggaggctcc agttggaatc tacctccagc agatgcccta
cccctgcttc gtggacgatt 2040ctttcatgat catcctgaac cgctgtttcc
ctatcttcat ggtgctggca tggatctact 2100ctgtctccat gactgtgaag
agcatcgtct tggagaagga gttgcgactg aaggagacct 2160tgaaaaatca
gggtgtctcc aatgcagtga tttggtgtac ctggttcctg gacagcttct
2220ccatcatgtc gatgagcatc ttcctcctga cgatattcat catgcatgga
agaatcctac 2280attacagcga cccattcatc ctcttcctgt tcttgttggc
tttctccact gccaccatca 2340tgctgtgctt tctgctcagc accttcttct
ccaaggccag tctggcagca gcctgtagtg 2400gtgtcatcta tttcaccctc
tacctgccac acatcctgtg cttcgcctgg caggaccgca 2460tgaccgctga
gctgaagaag gctgtgagct tactgtctcc ggtggcattt ggatttggca
2520ctgagtacct ggttcgcttt gaagagcaag gcctggggct gcagtggagc
aacatcggga 2580acagtcccac ggaaggggac gaattcagct tcctgctgtc
catgcagatg atgctccttg 2640atgctgctgt ctatggctta ctcgcttggt
accttgatca ggtgtttcca ggagactatg 2700gaaccccact tccttggtac
tttcttctac aagagtcgta ttggcttggc ggtgaagggt 2760gttcaaccag
agaagaaaga gccctggaaa agaccgagcc cctaacagag gaaacggagg
2820atccagagca cccagaagga atacacgact ccttctttga acgtgagcat
ccagggtggg 2880ttcctggggt atgcgtgaag aatctggtaa agatttttga
gccctgtggc cggccagctg 2940tggaccgtct gaacatcacc ttctacgaga
accagatcac cgcattcctg ggccacaatg 3000gagctgggaa aaccaccacc
ttgtccatcc tgacgggtct gttgccacca acctctggga 3060ctgtgctcgt
tgggggaagg gacattgaaa ccagcctgga tgcagtccgg cagagccttg
3120gcatgtgtcc acagcacaac atcctgttcc accacctcac ggtggctgag
cacatgctgt 3180tctatgccca gctgaaagga aagtcccagg aggaggccca
gctggagatg gaagccatgt 3240tggaggacac aggcctccac cacaagcgga
atgaagaggc tcaggaccta tcaggtggca 3300tgcagagaaa gctgtcggtt
gccattgcct ttgtgggaga tgccaaggtg gtgattctgg 3360acgaacccac
ctctggggtg gacccttact cgagacgctc aatctgggat ctgctcctga
3420agtatcgctc aggcagaacc atcatcatgt ccactcacca catggacgag
gccgacctcc 3480ttggggaccg cattgccatc attgcccagg gaaggctcta
ctgctcaggc accccactct 3540tcctgaagaa ctgctttggc acaggcttgt
acttaacctt ggtgcgcaag atgaaaaaca 3600tccagagcca aaggaaaggc
agtgagggga cctgcagctg ctcgtctaag ggtttctcca 3660ccacgtgtcc
agcccacgtc gatgacctaa ctccagaaca agtcctggat ggggatgtaa
3720atgagctgat ggatgtagtt ctccaccatg ttccagaggc aaagctggtg
gagtgcattg 3780gtcaagaact tatcttcctt cttccaaata agaacttcaa
gcacagagca tatgccagcc 3840ttttcagaga gctggaggag acgctggctg
accttggtct cagcagtttt ggaatttctg 3900acactcccct ggaagagatt
tttctgaagg tcacggagga ttctgattca ggacctctgt 3960ttgcgggtgg
cgctcagcag aaaagagaaa acgtcaaccc ccgacacccc tgcttgggtc
4020ccagagagaa ggctggacag acaccccagg actccaatgt ctgctcccca
ggggcgccgg 4080ctgctcaccc agagggccag cctcccccag agccagagtg
cccaggcccg cagctcaaca 4140cggggacaca gctggtcctc cagcatgtgc
aggcgctgct ggtcaagaga ttccaacaca 4200ccatccgcag ccacaaggac
ttcctggcgc agatcgtgct cccggctacc tttgtgtttt 4260tggctctgat
gctttctatt gttatccctc cttttggcga ataccccgct ttgacccttc
4320acccctggat atatgggcag cagtacacct tcttcagcat ggatgaacca
ggcagtgagc 4380agttcacggt acttgcagac gtcctcctga ataagccagg
ctttggcaac cgctgcctga 4440aggaagggtg gcttccggag tacccctgtg
gcaactcaac accctggaag actccttctg 4500tgtccccaaa catcacccag
ctgttccaga agcagaaatg gacacaggtc aacccttcac 4560catcctgcag
gtgcagcacc agggagaagc tcaccatgct gccagagtgc cccgagggtg
4620ccgggggcct cccgcccccc cagagaacac agcgcagcac ggaaattcta
caagacctga 4680cggacaggaa catctccgac ttcttggtaa aaacgtatcc
tgctcttata agaagcagct 4740taaagagcaa attctgggtc aatgaacaga
ggtatggagg aatttccatt ggaggaaagc 4800tcccagtcgt ccccatcacg
ggggaagcac ttgttgggtt tttaagcgac cttggccgga 4860tcatgaatgt
gagcgggggc cctatcacta gagaggcctc taaagaaata cctgatttcc
4920ttaaacatct agaaactgaa gacaacatta aggtgtggtt taataacaaa
ggctggcatg 4980ccctggtcag ctttctcaat gtggcccaca acgccatctt
acgggccagc ctgcctaagg 5040acaggagccc cgaggagtat ggaatcaccg
tcattagcca acccctgaac ctgaccaagg 5100agcagctctc agagattaca
gtgctgacca cttcagtgga tgctgtggtt gccatctgcg 5160tgattttctc
catgtccttc gtcccagcca gctttgtcct ttatttgatc caggagcggg
5220tgaacaaatc caagcacctc cagtttatca gtggagtgag ccccaccacc
tactgggtga 5280ccaacttcct ctgggacatc atgaattatt ccgtgagtgc
tgggctggtg gtgggcatct 5340tcatcgggtt tcagaagaaa gcctacactt
ctccagaaaa ccttcctgcc cttgtggcac 5400tgctcctgct gtatggatgg
gcggtcattc ccatgatgta cccagcatcc ttcctgtttg 5460atgtccccag
cacagcctat gtggctttat cttgtgctaa tctgttcatc ggcatcaaca
5520gcagtgctat taccttcatc ttggaattat ttgagaataa ccggacgctg
ctcaggttca 5580acgccgtgct gaggaagctg ctcattgtct tcccccactt
ctgcctgggc cggggcctca 5640ttgaccttgc actgagccag gctgtgacag
atgtctatgc ccggtttggt gaggagcact 5700ctgcaaatcc gttccactgg
gacctgattg ggaagaacct gtttgccatg gtggtggaag 5760gggtggtgta
cttcctcctg accctgctgg tccagcgcca cttcttcctc tcccaatgga
5820ttgccgagcc cactaaggag cccattgttg atgaagatga tgatgtggct
gaagaaagac 5880aaagaattat tactggtgga aataaaactg acatcttaag
gctacatgaa ctaaccaaga 5940tttatccagg cacctccagc ccagcagtgg
acaggctgtg tgtcggagtt cgccctggag 6000agtgctttgg cctcctggga
gtgaatggtg ccggcaaaac aaccacattc aagatgctca 6060ctggggacac
cacagtgacc tcaggggatg ccaccgtagc aggcaagagt attttaacca
6120atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca
attgatgagc 6180tgctcacagg acgagaacat ctttaccttt atgcccggct
tcgaggtgta ccagcagaag 6240aaatcgaaaa ggttgcaaac tggagtatta
agagcctggg cctgactgtc tacgccgact 6300gcctggctgg cacgtacagt
gggggcaaca agcggaaact ctccacagcc atcgcactca 6360ttggctgccc
accgctggtg ctgctggatg agcccaccac agggatggac ccccaggcac
6420gccgcatgct gtggaacgtc atcgtgagca tcatcagaga agggagggct
gtggtcctca 6480catcccacag catggaagaa tgtgaggcac tgtgtacccg
gctggccatc atggtaaagg 6540gcgcctttcg atgtatgggc accattcagc
atctcaagtc caaatttgga gatggctata 6600tcgtcacaat gaagatcaaa
tccccgaagg acgacctgct tcctgacctg aaccctgtgg 6660agcagttctt
ccaggggaac ttcccaggca gtgtgcagag ggagaggcac tacaacatgc
6720tccagttcca ggtctcctcc tcctccctgg cgaggatctt ccagctcctc
ctctcccaca 6780aggacagcct gctcatcgag gagtactcag tcacacagac
cacactggac caggtgtttg 6840taaattttgc taaacagcag actgaaagtc
atgacctccc tctgcaccct cgagctgctg 6900gagccagtcg acaagcccag
gactgatctt tcacaccgct cgttcctgca gccagaaagg 6960aactctgggc
agctggaggc gcaggagcct gtgcccatat ggtcatccaa atggactggc
7020cagcgtaaat gaccccactg cagcagaaaa caaacacacg aggagcatgc
agcgaattca 7080gaaagaggtc tttcagaagg aaaccgaaac tgacttgctc
acctggaaca cctgatggtg 7140aaaccaaaca aatacaaaat ccttctccag
accccagaac tagaaacccc gggccatccc 7200actagcagct ttggcctcca
tattgctctc atttcaagca gatctgcttt tctgcatgtt 7260tgtctgtgtg
tctgcgttgt gtgtgatttt catggaaaaa taaaatgcaa atgcactcat 7320cacaaa
7326132273PRTHomo sapiens 13Met Gly Phe Val Arg Gln Ile Gln Leu Leu
Leu Trp Lys Asn Trp Thr 1 5 10 15 Leu Arg Lys Arg Gln Lys Ile Arg
Phe Val Val Glu Leu Val Trp Pro 20 25 30 Leu Ser Leu Phe Leu Val
Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 35 40 45 Tyr Ser His His
Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 50 55 60 Gly Met
Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 65 70 75 80
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 85
90 95 Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu
Leu 100 105 110 Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile
Trp Thr Glu 115 120 125 Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu
Arg Thr His Pro Glu 130 135 140 Arg Ile Ala Gly Arg Gly Ile Arg Ile
Arg Asp Ile Leu Lys Asp Glu 145 150 155 160 Glu Thr Leu Thr Leu Phe
Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 165 170 175 Val Val Tyr Leu
Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 180 185 190 His Gly
Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 195 200 205
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 210
215 220 Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp
Ile 225 230 235 240 Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys
Leu Phe Arg Val 245 250 255 Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln
Gly Ile Asn Leu Arg Ser 260 265 270 Trp Gly Gly Ile Leu Ser Asp Met
Ser Pro Arg Ile Gln Glu Phe Ile 275 280 285 His Arg Pro Ser Met Gln
Asp Leu Leu Trp Val Thr Arg Pro Leu Met 290 295 300 Gln Asn Gly Gly
Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 305 310 315 320 Asp
Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 325 330
335 Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp
340 345 350 Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr
Thr Ser 355 360 365 Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn
Pro Leu Thr Lys 370 375 380 Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu
Met Gly Lys Ile Leu Tyr 385 390 395 400 Thr Pro Asp Ser Pro Ala Ala
Arg Arg Ile Leu Lys Asn Ala Asn Ser 405 410 415 Thr Phe Glu Glu Leu
Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 420 425 430 Glu Val Gly
Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 435 440 445 Asn
Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 450 455
460 Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn
465 470 475 480 Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp
Met Ala Asn 485 490 495 Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp
Arg Thr Leu Arg Leu 500 505 510 Val Asn Gln Tyr Leu Glu Cys Leu Val
Leu Asp Lys Phe Glu Ser Tyr 515 520 525 Asn Asp Glu Thr Gln Leu Thr
Gln Arg Ala Leu Ser Leu Leu Glu Glu 530 535 540 Asn Met Phe Trp Ala
Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 545 550 555 560 Ser Ser
Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 565 570 575
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 580
585 590 Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly
Phe 595 600 605 Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg
Ser Gln Val 610 615 620 Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln
Gln Met Pro Tyr Pro 625 630 635 640 Cys Phe Val Asp Asp Ser Phe Met
Ile Ile Leu Asn Arg Cys Phe Pro 645 650 655 Ile Phe Met Val Leu Ala
Trp Ile Tyr Ser Val Ser Met Thr Val Lys 660 665 670 Ser Ile Val Leu
Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 675 680 685 Gln Gly
Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 690 695 700
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 705
710 715 720 His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe
Leu Phe 725 730 735 Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys
Phe Leu Leu Ser 740 745 750 Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala
Ala Cys Ser Gly Val Ile 755 760 765 Tyr Phe Thr Leu Tyr Leu Pro His
Ile Leu Cys Phe Ala Trp Gln Asp 770 775 780 Arg Met Thr Ala Glu Leu
Lys Lys Ala Val Ser Leu Leu Ser Pro Val 785 790 795 800 Ala Phe Gly
Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 805 810 815 Leu
Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 820 825
830 Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala
835 840 845 Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro
Gly Asp 850 855 860 Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln
Glu Ser Tyr Trp 865 870 875 880 Leu Gly Gly Glu Gly Cys Ser Thr Arg
Glu Glu Arg Ala Leu Glu Lys 885 890 895 Thr Glu Pro Leu Thr Glu Glu
Thr Glu Asp Pro Glu His Pro Glu Gly 900 905 910 Ile His Asp Ser Phe
Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 915 920 925 Val Cys Val
Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 930 935 940 Ala
Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 945 950
955 960 Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile
Leu 965 970 975 Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val
Gly Gly Arg 980 985 990 Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln
Ser Leu Gly Met Cys 995 1000 1005 Pro Gln His Asn Ile Leu Phe His
His Leu Thr Val Ala Glu His 1010 1015 1020 Met Leu Phe Tyr Ala Gln
Leu Lys Gly Lys Ser Gln Glu Glu Ala 1025 1030 1035 Gln Leu Glu Met
Glu Ala Met Leu Glu Asp Thr Gly Leu His His 1040 1045 1050 Lys Arg
Asn Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg 1055 1060 1065
Lys Leu Ser Val Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val 1070
1075 1080 Ile Leu Asp Glu Pro Thr Ser Gly Val Asp Pro Tyr Ser Arg
Arg 1085 1090 1095 Ser Ile Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly
Arg Thr Ile 1100 1105 1110 Ile Met Ser Thr His His Met Asp Glu Ala
Asp Leu Leu Gly Asp 1115 1120 1125 Arg Ile Ala Ile Ile Ala Gln Gly
Arg Leu Tyr Cys Ser Gly Thr 1130
1135 1140 Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly Leu Tyr Leu
Thr 1145 1150 1155 Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg
Lys Gly Ser 1160 1165 1170 Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly
Phe Ser Thr Thr Cys 1175 1180 1185 Pro Ala His Val Asp Asp Leu Thr
Pro Glu Gln Val Leu Asp Gly 1190 1195 1200 Asp Val Asn Glu Leu Met
Asp Val Val Leu His His Val Pro Glu 1205 1210 1215 Ala Lys Leu Val
Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu Leu 1220 1225 1230 Pro Asn
Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg 1235 1240 1245
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly 1250
1255 1260 Ile Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr
Glu 1265 1270 1275 Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala
Gln Gln Lys 1280 1285 1290 Arg Glu Asn Val Asn Pro Arg His Pro Cys
Leu Gly Pro Arg Glu 1295 1300 1305 Lys Ala Gly Gln Thr Pro Gln Asp
Ser Asn Val Cys Ser Pro Gly 1310 1315 1320 Ala Pro Ala Ala His Pro
Glu Gly Gln Pro Pro Pro Glu Pro Glu 1325 1330 1335 Cys Pro Gly Pro
Gln Leu Asn Thr Gly Thr Gln Leu Val Leu Gln 1340 1345 1350 His Val
Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg 1355 1360 1365
Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe 1370
1375 1380 Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe
Gly 1385 1390 1395 Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr
Gly Gln Gln 1400 1405 1410 Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly
Ser Glu Gln Phe Thr 1415 1420 1425 Val Leu Ala Asp Val Leu Leu Asn
Lys Pro Gly Phe Gly Asn Arg 1430 1435 1440 Cys Leu Lys Glu Gly Trp
Leu Pro Glu Tyr Pro Cys Gly Asn Ser 1445 1450 1455 Thr Pro Trp Lys
Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu 1460 1465 1470 Phe Gln
Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys 1475 1480 1485
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro 1490
1495 1500 Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg
Ser 1505 1510 1515 Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile
Ser Asp Phe 1520 1525 1530 Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg
Ser Ser Leu Lys Ser 1535 1540 1545 Lys Phe Trp Val Asn Glu Gln Arg
Tyr Gly Gly Ile Ser Ile Gly 1550 1555 1560 Gly Lys Leu Pro Val Val
Pro Ile Thr Gly Glu Ala Leu Val Gly 1565 1570 1575 Phe Leu Ser Asp
Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro 1580 1585 1590 Ile Thr
Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His 1595 1600 1605
Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly 1610
1615 1620 Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala
Ile 1625 1630 1635 Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu
Glu Tyr Gly 1640 1645 1650 Ile Thr Val Ile Ser Gln Pro Leu Asn Leu
Thr Lys Glu Gln Leu 1655 1660 1665 Ser Glu Ile Thr Val Leu Thr Thr
Ser Val Asp Ala Val Val Ala 1670 1675 1680 Ile Cys Val Ile Phe Ser
Met Ser Phe Val Pro Ala Ser Phe Val 1685 1690 1695 Leu Tyr Leu Ile
Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln 1700 1705 1710 Phe Ile
Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe 1715 1720 1725
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val 1730
1735 1740 Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro
Glu 1745 1750 1755 Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr
Gly Trp Ala 1760 1765 1770 Val Ile Pro Met Met Tyr Pro Ala Ser Phe
Leu Phe Asp Val Pro 1775 1780 1785 Ser Thr Ala Tyr Val Ala Leu Ser
Cys Ala Asn Leu Phe Ile Gly 1790 1795 1800 Ile Asn Ser Ser Ala Ile
Thr Phe Ile Leu Glu Leu Phe Glu Asn 1805 1810 1815 Asn Arg Thr Leu
Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu 1820 1825 1830 Ile Val
Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu 1835 1840 1845
Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu 1850
1855 1860 Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys
Asn 1865 1870 1875 Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe
Leu Leu Thr 1880 1885 1890 Leu Leu Val Gln Arg His Phe Phe Leu Ser
Gln Trp Ile Ala Glu 1895 1900 1905 Pro Thr Lys Glu Pro Ile Val Asp
Glu Asp Asp Asp Val Ala Glu 1910 1915 1920 Glu Arg Gln Arg Ile Ile
Thr Gly Gly Asn Lys Thr Asp Ile Leu 1925 1930 1935 Arg Leu His Glu
Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro 1940 1945 1950 Ala Val
Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe 1955 1960 1965
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys 1970
1975 1980 Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr
Val 1985 1990 1995 Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val
His Gln Asn 2000 2005 2010 Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile
Asp Glu Leu Leu Thr 2015 2020 2025 Gly Arg Glu His Leu Tyr Leu Tyr
Ala Arg Leu Arg Gly Val Pro 2030 2035 2040 Ala Glu Glu Ile Glu Lys
Val Ala Asn Trp Ser Ile Lys Ser Leu 2045 2050 2055 Gly Leu Thr Val
Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly 2060 2065 2070 Gly Asn
Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys 2075 2080 2085
Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro 2090
2095 2100 Gln Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile
Arg 2105 2110 2115 Glu Gly Arg Ala Val Val Leu Thr Ser His Ser Met
Glu Glu Cys 2120 2125 2130 Glu Ala Leu Cys Thr Arg Leu Ala Ile Met
Val Lys Gly Ala Phe 2135 2140 2145 Arg Cys Met Gly Thr Ile Gln His
Leu Lys Ser Lys Phe Gly Asp 2150 2155 2160 Gly Tyr Ile Val Thr Met
Lys Ile Lys Ser Pro Lys Asp Asp Leu 2165 2170 2175 Leu Pro Asp Leu
Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe 2180 2185 2190 Pro Gly
Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe 2195 2200 2205
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu 2210
2215 2220 Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr
Gln 2225 2230 2235 Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys
Gln Gln Thr 2240 2245 2250 Glu Ser His Asp Leu Pro Leu His Pro Arg
Ala Ala Gly Ala Ser 2255 2260 2265 Arg Gln Ala Gln Asp 2270
142608DNAHomo sapiens 14tccttcttca ttctgcagtt ggtgccagaa ctctggatcc
tgaactggaa gaaaatgtct 60atccaggttg agcatcctgc tggtggttac aagaaactgt
ttgaaactgt ggaggaactg 120tcctcgccgc tcacagctca tgtaacaggc
aggatccccc tctggctcac cggcagtctc 180cttcgatgtg ggccaggact
ctttgaagtt ggatctgagc cattttacca cctgtttgat 240gggcaagccc
tcctgcacaa gtttgacttt aaagaaggac atgtcacata ccacagaagg
300ttcatccgca ctgatgctta cgtacgggca atgactgaga aaaggatcgt
cataacagaa 360tttggcacct gtgctttccc agatccctgc aagaatatat
tttccaggtt tttttcttac 420tttcgaggag tagaggttac tgacaatgcc
cttgttaatg tctacccagt gggggaagat 480tactacgctt gcacagagac
caactttatt acaaagatta atccagagac cttggagaca 540attaagcagg
ttgatctttg caactatgtc tctgtcaatg gggccactgc tcacccccac
600attgaaaatg atggaaccgt ttacaatatt ggtaattgct ttggaaaaaa
tttttcaatt 660gcctacaaca ttgtaaagat cccaccactg caagcagaca
aggaagatcc aataagcaag 720tcagagatcg ttgtacaatt cccctgcagt
gaccgattca agccatctta cgttcatagt 780tttggtctga ctcccaacta
tatcgttttt gtggagacac cagtcaaaat taacctgttc 840aagttccttt
cttcatggag tctttgggga gccaactaca tggattgttt tgagtccaat
900gaaaccatgg gggtttggct tcatattgct gacaaaaaaa ggaaaaagta
cctcaataat 960aaatacagaa cttctccttt caacctcttc catcacatca
acacctatga agacaatggg 1020tttctgattg tggatctctg ctgctggaaa
ggatttgagt ttgtttataa ttacttatat 1080ttagccaatt tacgtgagaa
ctgggaagag gtgaaaaaaa atgccagaaa ggctccccaa 1140cctgaagtta
ggagatatgt acttcctttg aatattgaca aggctgacac aggcaagaat
1200ttagtcacgc tccccaatac aactgccact gcaattctgt gcagtgacga
gactatctgg 1260ctggagcctg aagttctctt ttcagggcct cgtcaagcat
ttgagtttcc tcaaatcaat 1320taccagaagt attgtgggaa accttacaca
tatgcgtatg gacttggctt gaatcacttt 1380gttccagata ggctctgtaa
gctgaatgtc aaaactaaag aaacttgggt ttggcaagag 1440cctgattcat
acccatcaga acccatcttt gtttctcacc cagatgcctt ggaagaagat
1500gatggtgtag ttctgagtgt ggtggtgagc ccaggagcag gacaaaagcc
tgcttatctc 1560ctgattctga atgccaagga cttaagtgaa gttgcccggg
ctgaagtgga gattaacatc 1620cctgtcacct ttcatggact gttcaaaaaa
tcttgagcat actccagcaa gatatgtttt 1680tggtagcaaa actgagaaaa
tcagcttcag gtctgcaatc aaattctgtt caattttagc 1740ctgctatatg
tcatggtttt aacttgcaga tgcgcacaat tttgcaatgt tttacagaaa
1800gcactgagtt gagcaagcaa ttcctttatt taaaaaaaaa agtacgtatt
tagataatca 1860tacttcctct gtgagacagg ccataactga aaaactctta
aatatttagc aatcaaatag 1920gaaatgaatg tggacttact aaatggcttt
taattcctat tataagagca tattttaggt 1980acctatctgc tccaattata
tttttaacat ttaaaaacca aagtcctcta cacttgattt 2040atattatatg
tggctttgct gagtcaagga agtatcatgc aataaggctt aattactaaa
2100tgtcaaacca aactttttct caaaccaggg actatcatct aagattaatt
acagtaatta 2160ttttgcgtat acgtaactgc tcaaagatta tgaatcttat
gaatgttaac ctttccgttt 2220attacaagca agtactatta tttctgattt
tataataaga aaatctgtgt ttaatcaact 2280gaggcctctc aaccaaataa
catctcagag attaagttat atattaaaag cttatgtaac 2340ataaaagcaa
gtacatatag tagtgactat atttaaaaaa acagcataaa atgcttaaaa
2400atgtaatatt tactaaaatc agattatggg ataatgttgc aggattatac
tttattgcat 2460cttttttgtt taattgtatt taagcattgt gcaatcactt
gggaaaaata ttaaattatt 2520aacattgagg tattaataca ttttaagcct
tttgttttta aatttctttt cttccagaga 2580ttgtttaaaa ataaatattg acaaaaat
260815533PRTHomo sapiens 15Met Ser Ile Gln Val Glu His Pro Ala Gly
Gly Tyr Lys Lys Leu Phe 1 5 10 15 Glu Thr Val Glu Glu Leu Ser Ser
Pro Leu Thr Ala His Val Thr Gly 20 25 30 Arg Ile Pro Leu Trp Leu
Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 35 40 45 Leu Phe Glu Val
Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 50 55 60 Ala Leu
Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 65 70 75 80
Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 85
90 95 Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro
Cys 100 105 110 Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly
Val Glu Val 115 120 125 Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val
Gly Glu Asp Tyr Tyr 130 135 140 Ala Cys Thr Glu Thr Asn Phe Ile Thr
Lys Ile Asn Pro Glu Thr Leu 145 150 155 160 Glu Thr Ile Lys Gln Val
Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 165 170 175 Ala Thr Ala His
Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 180 185 190 Gly Asn
Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 195 200 205
Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 210
215 220 Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr
Val 225 230 235 240 His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe
Val Glu Thr Pro 245 250 255 Val Lys Ile Asn Leu Phe Lys Phe Leu Ser
Ser Trp Ser Leu Trp Gly 260 265 270 Ala Asn Tyr Met Asp Cys Phe Glu
Ser Asn Glu Thr Met Gly Val Trp 275 280 285 Leu His Ile Ala Asp Lys
Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 290 295 300 Arg Thr Ser Pro
Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 305 310 315 320 Asn
Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 325 330
335 Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu
340 345 350 Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg
Arg Tyr 355 360 365 Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly
Lys Asn Leu Val 370 375 380 Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile
Leu Cys Ser Asp Glu Thr 385 390 395 400 Ile Trp Leu Glu Pro Glu Val
Leu Phe Ser Gly Pro Arg Gln Ala Phe 405 410 415 Glu Phe Pro Gln Ile
Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 420 425 430 Tyr Ala Tyr
Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 435 440 445 Lys
Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 450 455
460 Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu
465 470 475 480 Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro
Gly Ala Gly 485 490 495 Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala
Lys Asp Leu Ser Glu 500 505 510 Val Ala Arg Ala Glu Val Glu Ile Asn
Ile Pro Val Thr Phe His Gly 515 520 525 Leu Phe Lys Lys Ser 530
161752DNAHomo sapiens 16gagcccgatt taacggaaac tgtgggcggt gagaagttcc
ttatgacaca ctaatcccaa 60cctgctgacc ggaccacgcc tccagcggag ggaacctcta
gagctccagg acattcaggt 120accaggtagc cccaaggagg agctgccgac
ctggcaggga acaaccaaga ctggggttaa 180atctcacagc ctgcaagtgg
aagagaagaa cttgaaccca ggtccaactt ttgcgccaca 240gcaggctgcc
tcttggtcct gacaggaagt cacaacttgg ccctgacttc ctatcctagg
300gaaggggccg gctggagagg ccaggacaga gaaagcagat cccttctttt
tccaaggact 360ctgtgtcttc cataggcaac atgtcagaag gggtgggcac
gttccgcatg gtacctgaag 420aggaacagga gctccgtgcc caactggagc
agctcacaac caaggaccat ggacctgtct 480ttggcccgtg cagccagctg
ccccgccaca ccttgcagaa ggccaaggat gagctgaacg 540agagagagga
gacccgggag gaggcagtgc gagagctgca ggagatggtg caggcgcagg
600cggcctcggg ggaggagctg gcggtggccg tggcggagag ggtgcaagag
aaggacagcg 660gcttcttcct gcgcttcatc cgcgcacgga agttcaacgt
gggccgtgcc tatgagctgc 720tcagaggcta tgtgaatttc cggctgcagt
accctgagct ctttgacagc ctgtccccag 780aggctgtccg ctgcaccatt
gaagctggct accctggtgt cctctctagt cgggacaagt 840atggccgagt
ggtcatgctc ttcaacattg agaactggca aagtcaagaa atcacctttg
900atgagatctt gcaggcatat tgcttcatcc tggagaagct gctggagaat
gaggaaactc 960aaatcaatgg cttctgcatc attgagaact tcaagggctt
taccatgcag caggctgcta 1020gtctccggac ttcagatctc aggaagatgg
tggacatgct ccaggattcc ttcccagccc 1080ggttcaaagc catccacttc
atccaccagc catggtactt caccacgacc tacaatgtgg 1140tcaagccctt
cttgaagagc aagctgcttg agagggtctt tgtccacggg gatgaccttt
1200ctggtttcta ccaggagatc gatgagaaca tcctgccctc tgacttcggg
ggcacgctgc 1260ccaagtatga tggcaaggcc gttgctgagc agctctttgg
cccccaggcc caagctgaga 1320acacagcctt ctgaaaacat ctcctgccag
ctgaactgta gttagaatct ctgggcctct 1380cctcaactgt cctggaccca
aggctaggaa agggctgctt gagatgactg tggtcccccc 1440ttagactccc
taagcccgag tgagctcagg tgtcaccctg ttctcaagtt gggggatggg
1500taataaagga gggggaattc ccttgaacaa gaagaactgg ggatagttat
atttccacct 1560gcccttgaag ctttaagaca gtgatttttg tgtaaggttg
tatttcaaag actcgaattc 1620attttctcag tcatttcctt tgtaacagag
ttttacgact tagagtctgt gaaaacaggc 1680aaggagcccg ggttaaaata
tccccctatt cgcccccaaa atgcaataaa agaagataaa 1740agagagagga ta
175217317PRTHomo sapiens 17Met Ser Glu Gly Val Gly Thr Phe Arg Met
Val Pro Glu Glu Glu Gln 1 5 10 15 Glu Leu Arg Ala Gln Leu Glu Gln
Leu Thr Thr Lys Asp His Gly Pro 20 25 30 Val Phe Gly Pro Cys Ser
Gln Leu Pro Arg His Thr Leu Gln Lys Ala 35 40 45 Lys Asp Glu Leu
Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 50 55 60 Glu Leu
Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 65 70 75 80
Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 85
90 95 Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr
Glu 100 105 110 Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro
Glu Leu Phe 115 120 125 Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr
Ile Glu Ala Gly Tyr 130 135 140 Pro Gly Val Leu Ser Ser Arg Asp Lys
Tyr Gly Arg Val Val Met Leu 145 150 155 160 Phe Asn Ile Glu Asn Trp
Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 165 170 175 Leu Gln Ala Tyr
Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 180 185 190 Thr Gln
Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 195 200 205
Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 210
215 220 Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His
Phe 225 230 235 240 Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn
Val Val Lys Pro 245 250 255 Phe Leu Lys Ser Lys Leu Leu Glu Arg Val
Phe Val His Gly Asp Asp 260 265 270 Leu Ser Gly Phe Tyr Gln Glu Ile
Asp Glu Asn Ile Leu Pro Ser Asp 275 280 285 Phe Gly Gly Thr Leu Pro
Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 290 295 300 Leu Phe Gly Pro
Gln Ala Gln Ala Glu Asn Thr Ala Phe 305 310 315 183027DNAHomo
sapiens 18cagcgttcag gctgcccctt cttggctggg aagggcgctg aagaaacaac
gcccaggacc 60aggactatcc cctgctcaag ctgtgattcc gagacccctg ccaccactac
tgcattcacg 120gggatcccag gctagtggga ctcgacatgg gtagccccca
gggcagctcc ctacagcttg 180ggccatctgc acttttccca aggccctaag
tctccgcctc tgggctcgtt aaggtttggg 240gtgggagctg tgctgtggga
agcaacccgg actacacttg gcaagcatgg cgctactgaa 300agtcaagttt
gaccagaaga agcgggtcaa gttggcccaa gggctctggc tcatgaactg
360gttctccgtg ttggctggca tcatcatctt cagcctagga ctgttcctga
agattgaact 420ccgaaagagg agcgatgtga tgaataattc tgagagccat
tttgtgccca actcattgat 480agggatgggg gtgctatcct gtgtcttcaa
ctcgctggct gggaagatct gctacgacgc 540cctggaccca gccaagtatg
ccagatggaa gccctggctg aagccgtacc tggctatctg 600tgttctcttc
aacatcatcc tcttccttgt ggctctctgc tgctttctgc ttcggggctc
660gctggagaac accctgggcc aagggctcaa gaacggcatg aagtactacc
gggacacaga 720cacccctggc aggtgtttca tgaagaagac catcgacatg
ctgcagatcg agttcaaatg 780ctgcggcaac aacggttttc gggactggtt
tgagattcag tggatcagca atcgctacct 840ggacttttcc tccaaagaag
tcaaagatcg aatcaagagc aacgtggatg ggcggtacct 900ggtggacggc
gtccctttca gctgctgcaa tcctagctcg ccacggccct gcatccagta
960tcagatcacc aacaactcag cacactacag ttacgaccac cagacggagg
agctcaacct 1020gtgggtgcgt ggctgcaggg ctgccctgct gagctactac
agcagcctca tgaactccat 1080gggtgtcgtc acgctcctca tttggctctt
cgaggtgacc attacaattg ggctgcgcta 1140cctacagacg tcgctggatg
gtgtgtccaa ccccgaggaa tctgagagcg agagccaggg 1200ctggctgctg
gagaggagcg tgccggagac ctggaaggcc tttctggaga gtgtgaagaa
1260gctgggcaag ggcaaccagg tggaagccga gggcgcagac gcaggccagg
ccccagaggc 1320tggctgaggg ccctggggcc cctcccctcc cgaacactga
gaaatagtgc actccaagaa 1380acgtggatct ccccctcatc caactccgaa
agtctgaatc tcccaaggag ggcaccatct 1440tacagagact ctccctgacg
gtggaattta agtttagggt ccctaaaagc atttgacaca 1500cagttgttga
atgactgacc caaaatgtga atgaagctaa tgtgaatgtg agtgaagctc
1560ccttcaggcc cgctgcccta ggatatgccc tcctggtgac tcgggggctg
tctcagacga 1620ctagcccagg acccatcttt ctcacacgga tttagtccca
ccctatggcc actggccgta 1680tctgagggct gctccccttt tagaatttac
ctcttatgag ctccatgttg cttcactcta 1740tccaaagtgt cacttggtgc
ataagcacag aaatctgaaa aatggccatg ttgtcttttt 1800tttttttttt
taatgccaag attgacaggt tggccgtttg cttaatgcca gaagttgggg
1860gaaagttacg cttttctaag aataatggac tcttaaggca ttgagggctc
taaacaggat 1920tctttaatca tggagcaaga gaatttcaag gcaggggatt
ttatccccca ccaaaaacac 1980agtgaaaggc ctgcttttgt gtcccattca
catgccctcg gtcactgagt ctggagtgaa 2040ccacgggttg aggaagtcag
gctgttggcg tgtcccagca ccacaccacc cctaaagtgc 2100caggtgatct
cctgtggctc atcggtggaa gcagtggggt aggctgctgc cctgctgtgg
2160aagaggagca acaatcagac atgagtccac cctttggaga ccaggcctca
gctcttggtg 2220ggcccaggga cacccacaca ggtggccatc acagccccat
ggacaacact aattgtccac 2280agcaaagggc aaggaatcct ctgggagctt
cttccgtttc ttccccccag atacccatct 2340tgaaaaacac tatttctgga
atgcttctgc atcaaaggag attctttgag atagcccatc 2400ttcctgagct
agcaaataca ggagttttca ctttctttag gaaagagaag ctttcagggg
2460aaggagagaa tgattttgct gacttcccaa gccctggtga ccagaccaag
gcagggccca 2520gcataattcc tccagttgga tgaacattca agagagctcg
ttcctacctg gctggagacc 2580gaggccagaa ggcaaaaacc agaaagggaa
cagtccataa cttacctctg cttctgaccg 2640atggtgtttg ggaataggtt
actttggact gagtttgggt tctctgctgt cctaagaact 2700tcagtgtaga
gaaaataaga cttctggtgc tgctggggta tgttctgggc ttaattcccc
2760caagcagaag accagatcca agatgtttgg acaccctgtc agacgttggt
cccaagttta 2820attagatttc tgaatctcgt tgaggccaag gaatgatcca
tactgaaaaa atgctgagcc 2880agccatcttt ggcaaaggtc cctgagctct
tgctatctct caagagtgct gagaaccacg 2940gtgaaagtgc tgctctaggc
ccacaagtgt aactatgctg ttaacagctg tcaatagata 3000attaaaattc
atactgtatg aaaatca 302719346PRTHomo sapiens 19Met Ala Leu Leu Lys
Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 1 5 10 15 Ala Gln Gly
Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 20 25 30 Ile
Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 35 40
45 Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu
50 55 60 Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala
Gly Lys 65 70 75 80 Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala
Arg Trp Lys Pro 85 90 95 Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val
Leu Phe Asn Ile Ile Leu 100 105 110 Phe Leu Val Ala Leu Cys Cys Phe
Leu Leu Arg Gly Ser Leu Glu Asn 115 120 125 Thr Leu Gly Gln Gly Leu
Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 130 135 140 Asp Thr Pro Gly
Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 145 150 155 160 Ile
Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 165 170
175 Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val
180 185 190 Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val
Asp Gly 195 200 205 Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg
Pro Cys Ile Gln 210 215 220 Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr
Ser Tyr Asp His Gln Thr 225 230 235 240 Glu Glu Leu Asn Leu Trp Val
Arg Gly Cys Arg Ala Ala Leu Leu Ser 245 250 255 Tyr Tyr Ser Ser Leu
Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 260 265 270 Trp Leu Phe
Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 275 280 285 Ser
Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Gln 290 295
300 Gly Trp Leu Leu Glu Arg Ser Val Pro Glu Thr Trp Lys Ala Phe Leu
305 310 315 320 Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu
Ala Glu Gly 325 330 335 Ala Asp Ala Gly Gln Ala Pro Glu Ala Gly 340
345 201767DNAHomo sapiens 20gtcagctggg tgactcatac atctgtgaga
ccctccgtat ggagaccggg gcggggggtg 60ttgcttaatg cttagaactg ctgaaactac
cagttcactg tctcagcact aatccaactc 120tgctccttaa gtgggatttg
gcttttagac attgagacct ggatgctggg catcctcgct 180agatccccta
caaattcccc acatacgtag gccaggagcc tcagcggtgc cccttcaggc
240tcatctggca agacggtacc agcttgctca gaacaggggc tggctattca
tcatctcaga 300gcatagagac cctctccttg ccacccggcc cttcccacct
ggttggtgac aaatcacaag 360gtggtagaag ttgccaggga cagataacat
ggcagccagc gggaagacca gcaagtccga 420accgaaccat gttatcttca
agaagatctc ccgggacaaa tcggtgacca tctacctggg 480gaacagagac
tacatagacc atgtcagcca agtccagcct gtggatggtg tcgtgttggt
540tgatcctgat cttgtgaagg gaaagaaagt gtatgtcact ctgacctgcg
ccttccgcta 600tggccaagag gacattgacg tgatcggctt gaccttccgc
agggacctgt acttctcccg 660ggtccaggtg tatcctcctg tgggggccgc
gagcaccccc acaaaactgc aagagagcct 720gcttaaaaag ctggggagca
acacgtaccc ctttctcctg acgtttcctg actacttgcc 780ctgttcagtg
atgttgcagc cagctccaca agattcaggg aagtcctgtg gggttgactt
840tgaggtcaaa gcattcgcca cagacagcac cgatgccgaa gaggacaaaa
tccccaagaa 900gagctccgtg cgattactga tccgcaaagt acagcatgcc
ccacttgaga tgggtcccca 960gccccgagct gaggcggcct ggcagttctt
catgtctgac aagcccctgc accttgcggt 1020ctctctcaac aaagagatct
atttccatgg ggagcccatc cctgtgaccg tgactgtcac 1080caataacaca
gagaagaccg tgaagaagat taaagcattc gtggaacagg tggccaatgt
1140ggttctctac tcgagtgatt attacgtcaa gcccgtggct atggaggaag
cgcaagaaaa 1200agtgccacca aacagcactt tgaccaagac gctgacgctg
ctgcccttgc tggctaacaa 1260tcgagaaagg agaggcattg ccctggatgg
gaaaatcaag cacgaggaca caaaccttgc 1320ctccagcacc atcattaagg
agggcataga ccggaccgtc ctgggaatcc tggtgtctta 1380ccagatcaag
gtgaagctca cagtgtcagg ctttctggga gagctcacct ccagtgaagt
1440cgccactgag gtcccattcc gcctcatgca ccctcagcct gaggacccag
ctaaggaaag 1500ttatcaggat gcaaatttag tttttgagga gtttgctcgc
cataatctga aagatgcagg 1560agaagctgag gaggggaaga gagacaagaa
tgacgttgat gagtgaagat gtcggctcag 1620gatgccggaa aatgacctgt
agttaccagt gcaacgagca aagccccaca gtttagtcct 1680ttggagttat
gctgcgtatg aaaggatgag tcttcttccg agaaataaag cttgtttgtt
1740ctcccctgga aaaaaaaaaa aaaaaaa 176721405PRTHomo sapiens 21Met
Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 1 5 10
15 Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn
20 25 30 Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp
Gly Val 35 40 45 Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys
Val Tyr Val Thr 50 55 60 Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu
Asp Ile Asp Val Ile Gly 65 70 75 80 Leu Thr Phe Arg Arg Asp Leu Tyr
Phe Ser Arg Val Gln Val Tyr Pro 85 90 95 Pro Val Gly Ala Ala Ser
Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 100 105 110 Lys Lys Leu Gly
Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 115 120 125 Tyr Leu
Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 130 135 140
Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 145
150 155 160 Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val
Arg Leu 165 170 175 Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met
Gly Pro Gln Pro 180 185 190 Arg Ala Glu Ala Ala Trp Gln Phe Phe Met
Ser Asp Lys Pro Leu His 195 200 205 Leu Ala Val Ser Leu Asn Lys Glu
Ile Tyr Phe His Gly Glu Pro Ile 210 215 220 Pro Val Thr Val Thr Val
Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 225 230 235 240 Ile Lys Ala
Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 245 250 255 Asp
Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 260 265
270 Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu
275 280 285 Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys
Ile Lys 290 295 300 His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile
Lys Glu Gly Ile 305 310 315 320 Asp Arg Thr Val Leu Gly Ile Leu Val
Ser Tyr Gln Ile Lys Val Lys 325 330 335 Leu Thr Val Ser Gly Phe Leu
Gly Glu Leu Thr Ser Ser Glu Val Ala 340 345 350 Thr Glu Val Pro Phe
Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 355 360 365 Lys Glu Ser
Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 370 375 380 His
Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 385 390
395 400 Asn Asp Val Asp Glu 405 222483DNAHomo sapiens 22agttgattgc
aggtcctcct ggggccagaa gggtgcctgg gaggccaggt tctggggatc 60ccctccatcc
agaagaacca cctgctcact ctgtcccttc gcctgctgct gggaccatgg
120gggctggggc cagtgctgag gagaagcact ccagggagct ggaaaagaag
ctgaaagagg 180acgctgagaa ggatgctcga accgtgaagc tgctgcttct
gggtgccggt gagtccggga 240agagcaccat cgtcaagcag atgaagatta
tccaccagga cgggtactcg ctggaagagt 300gcctcgagtt tatcgccatc
atctacggca acacgttgca gtccatcctg gccatcgtac 360gcgccatgac
cacactcaac atccagtacg gagactctgc acgccaggac gacgcccgga
420agctgatgca catggcagac actatcgagg agggcacgat gcccaaggag
atgtcggaca 480tcatccagcg gctgtggaag gactccggta tccaggcctg
ttttgagcgc gcctcggagt 540accagctcaa cgactcggcg ggctactacc
tctccgacct ggagcgcctg gtaaccccgg 600gctacgtgcc caccgagcag
gacgtgctgc gctcgcgagt caagaccact ggcatcatcg 660agacgcagtt
ctccttcaag gatctcaact tccggatgtt cgatgtgggc gggcagcgct
720cggagcgcaa gaagtggatc cactgcttcg agggcgtgac ctgcatcatc
ttcatcgcgg 780cgctgagcgc ctacgacatg gtgctagtgg aggacgacga
agtgaaccgc atgcacgaga 840gcctgcacct gttcaacagc atctgcaacc
accgctactt cgccacgacg tccatcgtgc 900tcttccttaa caagaaggac
gtcttcttcg agaagatcaa gaaggcgcac ctcagcatct 960gtttcccgga
ctacgatgga cccaacacct acgaggacgc cggcaactac atcaaggtgc
1020agttcctcga gctcaacatg cggcgcgacg tgaaggagat ctattcccac
atgacgtgcg 1080ccaccgacac gcagaacgtc aaatttgtct tcgacgctgt
caccgacatc atcatcaagg 1140agaacctcaa agactgtggc ctcttctgag
gccagggcct gtgctgcagt cggggacaag 1200gagcttccgt ctggcaaggc
cggggcacaa tttgcactcc cctcagctag acgcacagac 1260tcagcaataa
acctttgcat caggctccag ctgtcctttc ttggtggagg acttaattat
1320cacaagtcat gggcatttat taagtgccca gtgctgggtt gggcatgaag
tgggaagatg 1380gcccctccca ggaagaagta cctggcctga caaggtgggg
cactcttggg ggtatgggac 1440caactcatgg cttttcacgg gagttgagga
gagaggagct gtggaaaata ttcactggga 1500cagtcttgga tcaagaggga
gttttgaggt ggaggctcat tctggcaggg accgtagtgt 1560ctaccagccc
cagaaacatg ggcttatggc cacaggagtt cagtggagca agagcagggg
1620aggagagacg tggacaggtg cccaaagcca gtcggagggc ctgggctttc
tcagaaggtg 1680atggagagtc ttggaagccc tcgaggcagg aacataattg
cagggctggg attagggtga 1740gggaagtgag gcacactcac cttgggtgca
acatttaagg cgatgccaaa aaatttagta 1800accaaggtaa ataatattag
gataatattt ttaaaaatca aatgaatgca aaaccccaca 1860atgaatgaaa
tatcaaaatc caacagagga tcaaacagag gcatgctaag atatattggg
1920gcttgaagca aagggaaaac tatttgttgc tatatgtttg tagggatttt
ttgccagttt 1980taaaaataca tgtatcataa agtttactat ctcagccact
tgccggtgta tagtttggtg 2040gtgttaagta cattcataat gttgtacaac
caccgcaact gttcatctcc agaactcctt 2100tcctcttgta aaactgtaac
tctgtaccca tgaaaaaata accccccatt cctgccttcc 2160cccggctcct
ggcatccacc attctacttt ccatctctat gaatgtgact gctctaagtg
2220cctcagatgt gtgggtccat gaagtctttg tctttttgca actggcttat
ttcacttagc 2280atcatgtctt caaggtttat tcatgtgtag catatggcag
aatctccttc ctttttaagg 2340ttgaataata ttccattgta tatattccac
actttgttta tttattcatc tattgatgaa
2400tggttacatc tgccttttgg ctattgtgaa taatgctgct atgaacatgg
gtgtacaaat 2460ctctcaaaaa aaaaaaaaaa aaa 248323350PRTHomo sapiens
23Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 1
5 10 15 Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys
Leu 20 25 30 Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile
Val Lys Gln 35 40 45 Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu
Glu Glu Cys Leu Glu 50 55 60 Phe Ile Ala Ile Ile Tyr Gly Asn Thr
Leu Gln Ser Ile Leu Ala Ile 65 70 75 80 Val Arg Ala Met Thr Thr Leu
Asn Ile Gln Tyr Gly Asp Ser Ala Arg 85 90 95 Gln Asp Asp Ala Arg
Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 100 105 110 Gly Thr Met
Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 115 120 125 Asp
Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 130 135
140 Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr
145 150 155 160 Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser
Arg Val Lys 165 170 175 Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe
Lys Asp Leu Asn Phe 180 185 190 Arg Met Phe Asp Val Gly Gly Gln Arg
Ser Glu Arg Lys Lys Trp Ile 195 200 205 His Cys Phe Glu Gly Val Thr
Cys Ile Ile Phe Ile Ala Ala Leu Ser 210 215 220 Ala Tyr Asp Met Val
Leu Val Glu Asp Asp Glu Val Asn Arg Met His 225 230 235 240 Glu Ser
Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 245 250 255
Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 260
265 270 Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp
Gly 275 280 285 Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val
Gln Phe Leu 290 295 300 Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile
Tyr Ser His Met Thr 305 310 315 320 Cys Ala Thr Asp Thr Gln Asn Val
Lys Phe Val Phe Asp Ala Val Thr 325 330 335 Asp Ile Ile Ile Lys Glu
Asn Leu Lys Asp Cys Gly Leu Phe 340 345 350 24201PRTHomo sapiens
24Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 1
5 10 15 Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser
Gly 20 25 30 Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu
Lys Asn Leu 35 40 45 Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met
Phe Glu Thr Phe Asp 50 55 60 Phe Asn Lys Asp Gly Tyr Ile Asp Phe
Met Glu Tyr Val Ala Ala Leu 65 70 75 80 Ser Leu Val Leu Lys Gly Lys
Val Glu Gln Lys Leu Arg Trp Tyr Phe 85 90 95 Lys Leu Tyr Asp Val
Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 100 105 110 Leu Thr Ile
Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 115 120 125 Thr
Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 130 135
140 Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val
145 150 155 160 Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser
Leu Asp Leu 165 170 175 Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu
Gln Asp Glu Glu Gly 180 185 190 Ala Asp Glu Ala Ala Glu Ala Ala Gly
195 200 251103PRTHomo sapiens 25Met Thr Ala Cys Ala Arg Arg Ala Gly
Gly Leu Pro Asp Pro Gly Leu 1 5 10 15 Cys Gly Pro Ala Trp Trp Ala
Pro Ser Leu Pro Arg Leu Pro Arg Ala 20 25 30 Leu Pro Arg Leu Pro
Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 35 40 45 Ala Leu Ser
Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys 50 55 60 Asp
Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala 65 70
75 80 Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg
Phe 85 90 95 Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly
Ser Leu Gly 100 105 110 Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly
Leu Val Gly Pro Val 115 120 125 Asn Pro Ala Ala Cys Arg Pro Ala Glu
Leu Leu Ala Glu Glu Ala Gly 130 135 140 Ile Ala Leu Val Pro Trp Gly
Cys Pro Trp Thr Gln Ala Glu Gly Thr 145 150 155 160 Thr Ala Pro Ala
Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu 165 170 175 Arg Ala
Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp 180 185 190
Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg 195
200 205 Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu
Ser 210 215 220 Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro
Arg Val Thr 225 230 235 240 Ala Val Ile Met Val Met His Ser Val Leu
Leu Gly Gly Glu Glu Gln 245 250 255 Arg Tyr Leu Leu Glu Ala Ala Glu
Glu Leu Gly Leu Thr Asp Gly Ser 260 265 270 Leu Val Phe Leu Pro Phe
Asp Thr Ile His Tyr Ala Leu Ser Pro Gly 275 280 285 Pro Glu Ala Leu
Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala 290 295 300 His Asp
Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser 305 310 315
320 Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser
325 330 335 Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile
Tyr Asp 340 345 350 Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala
Arg Ala Ala Ala 355 360 365 Gly Gly Arg Trp Val Ser Gly Ala Ala Val
Ala Arg His Ile Arg Asp 370 375 380 Ala Gln Val Pro Gly Phe Cys Gly
Asp Leu Gly Gly Asp Glu Glu Pro 385 390 395 400 Pro Phe Val Leu Leu
Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala 405 410 415 Thr Tyr Met
Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr 420 425 430 Arg
Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser 435 440
445 Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly
450 455 460 Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu
Ala Gly 465 470 475 480 Ala Phe Leu Ala His Tyr Val Arg His Arg Leu
Leu His Met Gln Met 485 490 495 Val Ser Gly Pro Asn Lys Ile Ile Leu
Thr Val Asp Asp Ile Thr Phe 500 505 510 Leu His Pro His Gly Gly Thr
Ser Arg Lys Val Ala Gln Gly Ser Arg 515 520 525 Ser Ser Leu Gly Ala
Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser 530 535 540 Gln His Leu
Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val 545 550 555 560
Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala 565
570 575 Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn
Val 580 585 590 Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu
Gly Pro Ala 595 600 605 Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser
Glu His Cys Thr Arg 610 615 620 Gly Ser Leu Gln Asp Leu Leu Ala Gln
Arg Glu Ile Lys Leu Asp Trp 625 630 635 640 Met Phe Lys Ser Ser Leu
Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr 645 650 655 Leu His His Arg
Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys 660 665 670 Ile Val
Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly 675 680 685
Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu 690
695 700 Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu
Glu 705 710 715 720 Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu
Ala Ile Ile Met 725 730 735 Gln Glu Val Val Cys Arg Ser Ala Pro Tyr
Ala Met Leu Glu Leu Thr 740 745 750 Pro Glu Glu Val Val Gln Arg Val
Arg Ser Pro Pro Pro Leu Cys Arg 755 760 765 Pro Leu Val Ser Met Asp
Gln Ala Pro Val Glu Cys Ile Leu Leu Met 770 775 780 Lys Gln Cys Trp
Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His 785 790 795 800 Thr
Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile 805 810
815 Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu
820 825 830 Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys
Gln Lys 835 840 845 Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser
Val Ala Glu Ala 850 855 860 Leu Lys Thr Gly Thr Pro Val Glu Pro Glu
Tyr Phe Glu Gln Val Thr 865 870 875 880 Leu Tyr Phe Ser Asp Ile Val
Gly Phe Thr Thr Ile Ser Ala Met Ser 885 890 895 Glu Pro Ile Glu Val
Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe 900 905 910 Asp Ala Ile
Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly 915 920 925 Asp
Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg 930 935
940 His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val
945 950 955 960 Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val
Arg Ile Arg 965 970 975 Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly
Val Val Gly Leu Thr 980 985 990 Met Pro Arg Tyr Cys Leu Phe Gly Asp
Thr Val Asn Thr Ala Ser Arg 995 1000 1005 Met Glu Ser Thr Gly Leu
Pro Tyr Arg Ile His Val Asn Leu Ser 1010 1015 1020 Thr Val Gly Ile
Leu Arg Ala Leu Asp Ser Gly Tyr Gln Val Glu 1025 1030 1035 Leu Arg
Gly Arg Thr Glu Leu Lys Gly Lys Gly Ala Glu Asp Thr 1040 1045 1050
Phe Trp Leu Val Gly Arg Arg Gly Phe Asn Lys Pro Ile Pro Lys 1055
1060 1065 Pro Pro Asp Leu Gln Pro Gly Ser Ser Asn His Gly Ile Ser
Leu 1070 1075 1080 Gln Glu Ile Pro Pro Glu Arg Arg Arg Lys Leu Glu
Lys Ala Arg 1085 1090 1095 Pro Gly Gln Phe Ser 1100 26676PRTHomo
sapiens 26Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr
His Leu 1 5 10 15 Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala
Glu Asn Gly Leu 20 25 30 Ser Arg Ala His Ser Ser Ser Glu Glu Thr
Ser Ser Val Leu Gln Pro 35 40 45 Gly Ile Ala Met Glu Thr Arg Gly
Leu Ala Asp Ser Gly Gln Gly Ser 50 55 60 Phe Thr Gly Gln Gly Ile
Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 65 70 75 80 Arg Arg Trp Ala
Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 85 90 95 Ser Phe
Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 100 105 110
Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 115
120 125 Arg Gly Arg Arg Lys Lys Thr Lys Lys Lys Asp Ala Ile Val Val
Asp 130 135 140 Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile
Ala Leu Pro 145 150 155 160 Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys
Arg Ala Cys Phe Asp Glu 165 170 175 Leu Gln Ser Glu Tyr Leu Met Leu
Trp Leu Val Leu Asp Tyr Ser Ala 180 185 190 Asp Val Leu Tyr Val Leu
Asp Val Leu Val Arg Ala Arg Thr Gly Phe 195 200 205 Leu Glu Gln Gly
Leu Met Val Ser Asp Thr Asn Arg Leu Trp Gln His 210 215 220 Tyr Lys
Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 225 230 235
240 Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu Val Arg
245 250 255 Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe
Asp Arg 260 265 270 Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg
Ile Gly Asn Leu 275 280 285 Val Leu Tyr Ile Leu Ile Ile Ile His Trp
Asn Ala Cys Ile Tyr Phe 290 295 300 Ala Ile Ser Lys Phe Ile Gly Phe
Gly Thr Asp Ser Trp Val Tyr Pro 305 310 315 320 Asn Ile Ser Ile Pro
Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 325 330 335 Ser Leu Tyr
Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro 340 345 350 Pro
Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 355 360
365 Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly Ser Met
370 375 380 Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys
Ile Asp 385 390 395 400 Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val
Thr Lys Asp Leu Glu 405 410 415 Thr Arg Val Ile Arg Trp Phe Asp Tyr
Leu Trp Ala Asn Lys Lys Thr 420 425 430 Val Asp Glu Lys Glu Val Leu
Lys Ser Leu Pro Asp Lys Leu Lys Ala 435 440 445 Glu Ile Ala Ile Asn
Val His Leu Asp Thr Leu Lys Lys Val Arg Ile 450 455 460 Phe Gln Asp
Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 465 470 475 480
Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 485
490 495 Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val
Val 500 505 510 Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp
Gly Ser Tyr 515 520 525 Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly
Ser Lys Ser Gly Asn 530 535 540 Arg Arg Thr Ala Asn Ile Arg Ser Ile
Gly Tyr Ser Asp Leu Phe Cys 545 550 555 560 Leu Ser Lys Asp Asp Leu
Met Glu Ala Leu Thr Glu Tyr Pro Glu Ala 565 570 575 Lys Lys Ala Leu
Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 580 585 590 Leu Ile
Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 595 600 605
Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu Gln Thr
610
615 620 Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met Lys
Met 625 630 635 640 Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys
Gly Gly Gly Asp 645 650 655 Lys Pro Leu Ala Asp Gly Glu Val Pro Gly
Asp Ala Thr Lys Thr Glu 660 665 670 Asp Lys Gln Gln 675
27694PRTHomo sapiens 27Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro
Ser Arg Thr His Leu 1 5 10 15 Lys Val Lys Thr Ser Asp Arg Asp Leu
Asn Arg Ala Glu Asn Gly Leu 20 25 30 Ser Arg Ala His Ser Ser Ser
Glu Glu Thr Ser Ser Val Leu Gln Pro 35 40 45 Gly Ile Ala Met Glu
Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 50 55 60 Phe Thr Gly
Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 65 70 75 80 Arg
Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 85 90
95 Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser
100 105 110 Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro
Ala Asp 115 120 125 Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn
Thr Asn Thr Ser 130 135 140 Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys
Lys Lys Asp Ala Ile Val 145 150 155 160 Val Asp Pro Ser Ser Asn Leu
Tyr Tyr Arg Trp Leu Thr Ala Ile Ala 165 170 175 Leu Pro Val Phe Tyr
Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 180 185 190 Asp Glu Leu
Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 195 200 205 Ser
Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr 210 215
220 Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp
225 230 235 240 Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val
Leu Ser Leu 245 250 255 Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly
Thr Asn Tyr Pro Glu 260 265 270 Val Arg Phe Asn Arg Leu Leu Lys Phe
Ser Arg Leu Phe Glu Phe Phe 275 280 285 Asp Arg Thr Glu Thr Arg Thr
Asn Tyr Pro Asn Met Phe Arg Ile Gly 290 295 300 Asn Leu Val Leu Tyr
Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 305 310 315 320 Tyr Phe
Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val 325 330 335
Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 340
345 350 Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly
Glu 355 360 365 Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val
Val Val Asp 370 375 380 Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile
Val Gly Asn Val Gly 385 390 395 400 Ser Met Ile Ser Asn Met Asn Ala
Ser Arg Ala Glu Phe Gln Ala Lys 405 410 415 Ile Asp Ser Ile Lys Gln
Tyr Met Gln Phe Arg Lys Val Thr Lys Asp 420 425 430 Leu Glu Thr Arg
Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 435 440 445 Lys Thr
Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 450 455 460
Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val 465
470 475 480 Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu
Val Leu 485 490 495 Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr
Ile Cys Lys Lys 500 505 510 Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile
Asn Glu Gly Lys Leu Ala 515 520 525 Val Val Ala Asp Asp Gly Val Thr
Gln Phe Val Val Leu Ser Asp Gly 530 535 540 Ser Tyr Phe Gly Glu Ile
Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 545 550 555 560 Gly Asn Arg
Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 565 570 575 Phe
Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro 580 585
590 Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys
595 600 605 Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp
Pro Lys 610 615 620 Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser
Leu Asp Thr Leu 625 630 635 640 Gln Thr Arg Phe Ala Arg Leu Leu Ala
Glu Tyr Asn Ala Thr Gln Met 645 650 655 Lys Met Lys Gln Arg Leu Ser
Gln Leu Glu Ser Gln Val Lys Gly Gly 660 665 670 Gly Asp Lys Pro Leu
Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys 675 680 685 Thr Glu Asp
Lys Gln Gln 690 28354PRTHomo sapiens 28Met Gly Ser Gly Ala Ser Ala
Glu Asp Lys Glu Leu Ala Lys Arg Ser 1 5 10 15 Lys Glu Leu Glu Lys
Lys Leu Gln Glu Asp Ala Asp Lys Glu Ala Lys 20 25 30 Thr Val Lys
Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 35 40 45 Ile
Val Lys Gln Met Lys Ile Ile His Gln Asp Gly Tyr Ser Pro Glu 50 55
60 Glu Cys Leu Glu Phe Lys Ala Ile Ile Tyr Gly Asn Val Leu Gln Ser
65 70 75 80 Ile Leu Ala Ile Ile Arg Ala Met Thr Thr Leu Gly Ile Asp
Tyr Ala 85 90 95 Glu Pro Ser Cys Ala Asp Asp Gly Arg Gln Leu Asn
Asn Leu Ala Asp 100 105 110 Ser Ile Glu Glu Gly Thr Met Pro Pro Glu
Leu Val Glu Val Ile Arg 115 120 125 Arg Leu Trp Lys Asp Gly Gly Val
Gln Ala Cys Phe Glu Arg Ala Ala 130 135 140 Glu Tyr Gln Leu Asn Asp
Ser Ala Ser Tyr Tyr Leu Asn Gln Leu Glu 145 150 155 160 Arg Ile Thr
Asp Pro Glu Tyr Leu Pro Ser Glu Gln Asp Val Leu Arg 165 170 175 Ser
Arg Val Lys Thr Thr Gly Ile Ile Glu Thr Lys Phe Ser Val Lys 180 185
190 Asp Leu Asn Phe Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg
195 200 205 Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Cys Ile Ile
Phe Cys 210 215 220 Ala Ala Leu Ser Ala Tyr Asp Met Val Leu Val Glu
Asp Asp Glu Val 225 230 235 240 Asn Arg Met His Glu Ser Leu His Leu
Phe Asn Ser Ile Cys Asn His 245 250 255 Lys Phe Phe Ala Ala Thr Ser
Ile Val Leu Phe Leu Asn Lys Lys Asp 260 265 270 Leu Phe Glu Glu Lys
Ile Lys Lys Val His Leu Ser Ile Cys Phe Pro 275 280 285 Glu Tyr Asp
Gly Asn Asn Ser Tyr Asp Asp Ala Gly Asn Tyr Ile Lys 290 295 300 Ser
Gln Phe Leu Asp Leu Asn Met Arg Lys Asp Val Lys Glu Ile Tyr 305 310
315 320 Ser His Met Thr Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val
Phe 325 330 335 Asp Ala Val Thr Asp Ile Ile Ile Lys Glu Asn Leu Lys
Asp Cys Gly 340 345 350 Leu Phe 29858PRTHomo sapiens 29Met Gly Glu
Ile Asn Gln Val Ala Val Glu Lys Tyr Leu Glu Glu Asn 1 5 10 15 Pro
Gln Phe Ala Lys Glu Tyr Phe Asp Arg Lys Leu Arg Val Glu Val 20 25
30 Leu Gly Glu Ile Phe Lys Asn Ser Gln Val Pro Val Gln Ser Ser Met
35 40 45 Ser Phe Ser Glu Leu Thr Gln Val Glu Glu Ser Ala Leu Cys
Leu Glu 50 55 60 Leu Leu Trp Thr Val Gln Glu Glu Gly Gly Thr Pro
Glu Gln Gly Val 65 70 75 80 His Arg Ala Leu Gln Arg Leu Ala His Leu
Leu Gln Ala Asp Arg Cys 85 90 95 Ser Met Phe Leu Cys Arg Ser Arg
Asn Gly Ile Pro Glu Val Ala Ser 100 105 110 Arg Leu Leu Asp Val Thr
Pro Thr Ser Lys Phe Glu Asp Asn Leu Val 115 120 125 Gly Pro Asp Lys
Glu Val Val Phe Pro Leu Asp Ile Gly Ile Val Gly 130 135 140 Trp Ala
Ala His Thr Lys Lys Thr His Asn Val Pro Asp Val Lys Lys 145 150 155
160 Asn Ser His Phe Ser Asp Phe Met Asp Lys Gln Thr Gly Tyr Val Thr
165 170 175 Lys Asn Leu Leu Ala Thr Pro Ile Val Val Gly Lys Glu Val
Leu Ala 180 185 190 Val Ile Met Ala Val Asn Lys Val Asn Ala Ser Glu
Phe Ser Lys Gln 195 200 205 Asp Glu Glu Val Phe Ser Lys Tyr Leu Asn
Phe Val Ser Ile Ile Leu 210 215 220 Arg Leu His His Thr Ser Tyr Met
Tyr Asn Ile Glu Ser Arg Arg Ser 225 230 235 240 Gln Ile Leu Met Trp
Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp 245 250 255 Val Glu Arg
Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ser Tyr Leu 260 265 270 Asn
Cys Glu Arg Tyr Ser Ile Gly Leu Leu Asp Met Thr Lys Glu Lys 275 280
285 Glu Phe Tyr Asp Glu Trp Pro Ile Lys Leu Gly Glu Val Glu Pro Tyr
290 295 300 Lys Gly Pro Lys Thr Pro Asp Gly Arg Glu Val Asn Phe Tyr
Lys Ile 305 310 315 320 Ile Asp Tyr Ile Leu His Gly Lys Glu Glu Ile
Lys Val Ile Pro Thr 325 330 335 Pro Pro Ala Asp His Trp Thr Leu Ile
Ser Gly Leu Pro Thr Tyr Val 340 345 350 Ala Glu Asn Gly Phe Ile Cys
Asn Met Met Asn Ala Pro Ala Asp Glu 355 360 365 Tyr Phe Thr Phe Gln
Lys Gly Pro Val Asp Glu Thr Gly Trp Val Ile 370 375 380 Lys Asn Val
Leu Ser Leu Pro Ile Val Asn Lys Lys Glu Asp Ile Val 385 390 395 400
Gly Val Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu 405
410 415 His Asp Glu Tyr Ile Thr Glu Thr Leu Thr Gln Phe Leu Gly Trp
Ser 420 425 430 Leu Leu Asn Thr Asp Thr Tyr Asp Lys Met Asn Lys Leu
Glu Asn Arg 435 440 445 Lys Asp Ile Ala Gln Glu Met Leu Met Asn Gln
Thr Lys Ala Thr Pro 450 455 460 Glu Glu Ile Lys Ser Ile Leu Lys Phe
Gln Glu Lys Leu Asn Val Asp 465 470 475 480 Val Ile Asp Asp Cys Glu
Glu Lys Gln Leu Val Ala Ile Leu Lys Glu 485 490 495 Asp Leu Pro Asp
Pro Arg Ser Ala Glu Leu Tyr Glu Phe Arg Phe Ser 500 505 510 Asp Phe
Pro Leu Thr Glu His Gly Leu Ile Lys Cys Gly Ile Arg Leu 515 520 525
Phe Phe Glu Ile Asn Val Val Glu Lys Phe Lys Val Pro Val Glu Val 530
535 540 Leu Thr Arg Trp Met Tyr Thr Val Arg Lys Gly Tyr Arg Ala Val
Thr 545 550 555 560 Tyr His Asn Trp Arg His Gly Phe Asn Val Gly Gln
Thr Met Phe Thr 565 570 575 Leu Leu Met Thr Gly Arg Leu Lys Lys Tyr
Tyr Thr Asp Leu Glu Ala 580 585 590 Phe Ala Met Leu Ala Ala Ala Phe
Cys His Asp Ile Asp His Arg Gly 595 600 605 Thr Asn Asn Leu Tyr Gln
Met Lys Ser Thr Ser Pro Leu Ala Arg Leu 610 615 620 His Gly Ser Ser
Ile Leu Glu Arg His His Leu Glu Tyr Ser Lys Thr 625 630 635 640 Leu
Leu Gln Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Lys Arg 645 650
655 Gln Phe Glu Thr Val Ile His Leu Phe Glu Val Ala Ile Ile Ala Thr
660 665 670 Asp Leu Ala Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys
Ile Val 675 680 685 Asp Ala Cys Glu Gln Met Gln Thr Glu Glu Glu Ala
Ile Lys Tyr Val 690 695 700 Thr Val Asp Pro Thr Lys Lys Glu Ile Ile
Met Ala Met Met Met Thr 705 710 715 720 Ala Cys Asp Leu Ser Ala Ile
Thr Lys Pro Trp Glu Val Gln Ser Gln 725 730 735 Val Ala Leu Met Val
Ala Asn Glu Phe Trp Glu Gln Gly Asp Leu Glu 740 745 750 Arg Thr Val
Leu Gln Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys 755 760 765 Arg
Asp Glu Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys 770 775
780 Thr Phe Val Tyr Lys Glu Phe Ser Arg Phe His Lys Glu Ile Thr Pro
785 790 795 800 Met Leu Ser Gly Leu Gln Asn Asn Arg Val Glu Trp Lys
Ser Leu Ala 805 810 815 Asp Glu Tyr Asp Ala Lys Met Lys Val Ile Glu
Glu Glu Ala Lys Lys 820 825 830 Gln Glu Gly Gly Ala Glu Lys Ala Ala
Glu Asp Ser Gly Gly Gly Asp 835 840 845 Asp Lys Lys Ser Lys Thr Cys
Leu Met Leu 850 855 3083PRTHomo sapiens 30Met Ser Asp Asn Thr Thr
Leu Pro Ala Pro Ala Ser Asn Gln Gly Pro 1 5 10 15 Thr Thr Pro Arg
Lys Gly Pro Pro Lys Phe Lys Gln Arg Gln Thr Arg 20 25 30 Gln Phe
Lys Ser Lys Pro Pro Lys Lys Gly Val Lys Gly Phe Gly Asp 35 40 45
Asp Ile Pro Gly Met Glu Gly Leu Gly Thr Asp Ile Thr Val Ile Cys 50
55 60 Pro Trp Glu Ala Phe Ser His Leu Glu Leu His Glu Leu Ala Gln
Phe 65 70 75 80 Gly Ile Ile 31299PRTHomo sapiens 31Met Met Ala Tyr
Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 1 5 10 15 Ala Leu
Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 20 25 30
Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 35
40 45 Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr
Pro 50 55 60 Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn
Leu Pro Glu 65 70 75 80 Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg
Ala Lys Cys Arg Gln 85 90 95 Gln Arg Gln Gln Gln Lys Gln Gln Gln
Gln Pro Pro Gly Gly Gln Ala 100 105 110 Lys Ala Arg Pro Ala Lys Arg
Lys Ala Gly Thr Ser Pro Arg Pro Ser 115 120 125 Thr Asp Val Cys Pro
Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 130 135 140 Pro Leu Pro
Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 145 150 155 160
Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 165
170 175 Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr
Ala 180 185 190 Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro
Ser Ala Tyr 195 200 205 Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp
Pro Tyr Leu Ser Pro 210 215 220 Met Val Pro Gln Leu Gly Gly Pro Ala
Leu Ser Pro Leu Ser Gly Pro 225 230 235 240 Ser Val Gly Pro Ser Leu
Ala Gln Ser Pro Thr
Ser Leu Ser Gly Gln 245 250 255 Ser Tyr Gly Ala Tyr Ser Pro Val Asp
Ser Leu Glu Phe Lys Asp Pro 260 265 270 Thr Gly Thr Trp Lys Phe Thr
Tyr Asn Pro Met Asp Pro Leu Asp Tyr 275 280 285 Lys Asp Gln Ser Ala
Trp Lys Phe Gln Ile Leu 290 295 32809PRTHomo sapiens 32Met Phe Lys
Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 1 5 10 15 Asn
Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 20 25
30 Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly
35 40 45 Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser
Glu Glu 50 55 60 Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys
Asn Ser Ser Gly 65 70 75 80 Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn
Ala Ala Glu Pro Thr Gly 85 90 95 Thr Val Pro Glu Gln Lys Glu Met
Asp Pro Gly Lys Glu Gly Pro Asn 100 105 110 Ser Pro Gln Asn Lys Pro
Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 115 120 125 Asp Ala Gln Leu
His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 130 135 140 Leu Tyr
Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 145 150 155
160 Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser
165 170 175 Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe
Lys Val 180 185 190 Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile
Lys Leu Pro Asn 195 200 205 Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr
Leu Leu Trp Leu Leu Leu 210 215 220 Val Thr Leu Ala Tyr Asn Trp Asn
Cys Trp Phe Ile Pro Leu Arg Leu 225 230 235 240 Val Phe Pro Tyr Gln
Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 245 250 255 Asp Ile Ile
Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 260 265 270 Pro
Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 275 280
285 Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val
290 295 300 Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly
Phe Asn 305 310 315 320 Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr
Thr Ser Phe Phe Glu 325 330 335 Phe Asn His His Leu Glu Ser Ile Met
Asp Lys Ala Tyr Ile Tyr Arg 340 345 350 Val Ile Arg Thr Thr Gly Tyr
Leu Leu Phe Ile Leu His Ile Asn Ala 355 360 365 Cys Val Tyr Tyr Trp
Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 370 375 380 Trp Val Tyr
Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 385 390 395 400
Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 405
410 415 Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val
Phe 420 425 430 Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile
Gly Ala Ala 435 440 445 Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met
Asp Asp Thr Ile Ala 450 455 460 Tyr Met Asn Asn Tyr Ser Ile Pro Lys
Leu Val Gln Lys Arg Val Arg 465 470 475 480 Thr Trp Tyr Glu Tyr Thr
Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 485 490 495 Asp Leu Leu Lys
Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 500 505 510 Asp Val
Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 515 520 525
Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 530
535 540 Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys
Glu 545 550 555 560 Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu
Gly Gly Pro Asp 565 570 575 Gly Thr Lys Val Leu Val Thr Leu Lys Ala
Gly Ser Val Phe Gly Glu 580 585 590 Ile Ser Leu Leu Ala Ala Gly Gly
Gly Asn Arg Arg Thr Ala Asn Val 595 600 605 Val Ala His Gly Phe Ala
Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 610 615 620 Gln Glu Ile Leu
Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 625 630 635 640 Lys
Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 645 650
655 Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr
660 665 670 Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala
Ser Leu 675 680 685 Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala
Gln Lys Lys Glu 690 695 700 Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys
Glu Asn Glu Asp Lys Gln 705 710 715 720 Lys Glu Asn Glu Asp Lys Gln
Lys Glu Asn Glu Asp Lys Gly Lys Glu 725 730 735 Asn Glu Asp Lys Asp
Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 740 745 750 Arg Pro Glu
Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 755 760 765 Ser
Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 770 775
780 Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr
785 790 795 800 Ile Glu Val Lys Glu Lys Ala Lys Gln 805
33610PRTHomo sapiens 33Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys
Leu Pro Asn Ser Ile 1 5 10 15 Asp Ser Tyr Thr Asp Arg Leu Tyr Leu
Leu Trp Leu Leu Leu Val Thr 20 25 30 Leu Ala Tyr Asn Trp Asn Cys
Cys Phe Ile Pro Leu Arg Leu Val Phe 35 40 45 Pro Tyr Gln Thr Ala
Asp Asn Ile His Tyr Trp Leu Ile Ala Asp Ile 50 55 60 Ile Cys Asp
Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln Pro Arg 65 70 75 80 Leu
Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn Glu Leu 85 90
95 Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val Ala Ser
100 105 110 Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn
Pro Met 115 120 125 Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe
Phe Glu Phe Asn 130 135 140 His His Leu Glu Ser Ile Met Asp Lys Ala
Tyr Ile Tyr Arg Val Ile 145 150 155 160 Arg Thr Thr Gly Tyr Leu Leu
Phe Ile Leu His Ile Asn Ala Cys Val 165 170 175 Tyr Tyr Trp Ala Ser
Asn Tyr Glu Gly Ile Gly Thr Thr Arg Trp Val 180 185 190 Tyr Asp Gly
Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp Ala Val 195 200 205 Arg
Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr Leu Phe 210 215
220 Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe Val Phe
225 230 235 240 Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala
Ala Thr Ala 245 250 255 Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp
Thr Ile Ala Tyr Met 260 265 270 Asn Asn Tyr Ser Ile Pro Lys Leu Val
Gln Lys Arg Val Arg Thr Trp 275 280 285 Tyr Glu Tyr Thr Trp Asp Ser
Gln Arg Met Leu Asp Glu Ser Asp Leu 290 295 300 Leu Lys Thr Leu Pro
Thr Thr Val Gln Leu Ala Leu Ala Ile Asp Val 305 310 315 320 Asn Phe
Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys Asp Thr 325 330 335
Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu Tyr Leu 340
345 350 Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu Met
Tyr 355 360 365 Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro
Asp Gly Thr 370 375 380 Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val
Leu Leu Ala Ala Gly 385 390 395 400 Gly Gly Asn Arg Arg Thr Ala Asn
Val Val Ala His Gly Phe Ala Asn 405 410 415 Leu Leu Thr Leu Asp Lys
Lys Thr Leu Gln Glu Ile Leu Val His Tyr 420 425 430 Pro Asp Ser Glu
Arg Ile Leu Met Lys Lys Ala Arg Val Leu Leu Lys 435 440 445 Gln Lys
Ala Lys Thr Ala Glu Ala Thr Pro Pro Arg Lys Asp Leu Ala 450 455 460
Leu Leu Phe Pro Pro Lys Glu Glu Thr Pro Lys Leu Phe Lys Thr Leu 465
470 475 480 Leu Gly Gly Thr Gly Lys Ala Ser Leu Ala Arg Leu Leu Lys
Leu Lys 485 490 495 Arg Glu Gln Ala Ala Gln Lys Lys Glu Asn Ser Glu
Gly Gly Glu Glu 500 505 510 Glu Gly Lys Glu Asn Glu Asp Lys Gln Lys
Glu Asn Glu Asp Lys Gln 515 520 525 Lys Glu Asn Glu Asp Lys Gly Lys
Glu Asn Glu Asp Lys Asp Lys Gly 530 535 540 Arg Glu Pro Glu Glu Lys
Pro Leu Asp Arg Pro Glu Cys Thr Ala Ser 545 550 555 560 Pro Ile Ala
Val Glu Glu Glu Pro His Ser Val Arg Arg Thr Val Leu 565 570 575 Pro
Arg Gly Thr Ser Arg Gln Ser Leu Ile Ile Ser Met Ala Pro Ser 580 585
590 Ala Glu Gly Gly Glu Glu Val Leu Thr Ile Glu Val Lys Glu Lys Ala
595 600 605 Lys Gln 610 347100DNAHomo sapiens 34gacatactga
gaataaatcc aaagacatta gtttctttgc acgaaatgag gttacatatc 60cagtgacatt
tatttgagct atttaaacaa cttaaacatc tttttctttt cttaataagg
120gacgtttcaa gttgtggtct cagccaaaat gagtgatacc ccttctactg
gtttttccat 180cattcatcct acgtcttctg aaggtcaagt tccaccccct
cgccatttga gcctcactca 240tcctgttgtg gccaagcgaa tcagtttcta
caagagcgga gacccccaat tcggcggggt 300cagggtggtg gtcaaccctc
gctcctttaa gtcctttgat gctctgctgg ataacttgtc 360caggaaggtg
cccctccctt ttggagtgag gaacatcagc acccctcggg gcaggcacag
420catcacgcgc ctggaggagc tggaggacgg cgagtcctac ctatgttccc
acggcaggaa 480ggtgcagcct gtagacctgg acaaagcccg tcggcgcccg
cggccctggc tcagcagccg 540ggccattagc gcgcactcac cgccccaccc
cgtagccgtc gctgctcccg gcatgccccg 600ccccccacgg agcctagtgg
tcttcaggaa tggcgacccg aagacgaggc gtgcggttct 660tctgagcagg
agggtcaccc agagcttcga ggcatttcta cagcacctga cagaggtcat
720gcagcgccct gtggtcaagc tgtacgctac ggacggaagg agggttccca
gcctccaggc 780agtgatcctg agctctggag ctgtggtggc ggcaggaagg
gagccattta aaccaggaaa 840ttatgacatc caaaaatact tgcttcctgc
tagattacca gggatctctc agcgtgtgta 900ccccaaggga aatgcaaagt
cagaaagcag aaagataagc acacatatgt cttcaagctc 960aaggtcccag
atttattctg tttcttctga gaaaacacat aataatgatt gctacttaga
1020ctattctttt gttcctgaaa agtacttggc cttagaaaag aatgattctc
agaatttacc 1080aatatatcct tctgaagatg atattgagaa atcaattatt
tttaatcaag acggcactat 1140gacagttgag atgaaagttc gattcagaat
aaaagaggaa gaaaccataa aatggacaac 1200tactgtcagt aaaactggtc
cttctaataa tgatgaaaag agtgagatga gttttccagg 1260aagaacagaa
agtcgatcat ctggtttaaa gcttgcagca tgttcattct ctgcagatgt
1320gtcacctatg gagcgaagca gtaatcaaga gggcagtttg gcagaggaga
taaacattca 1380aatgacagat caagtggctg aaacttgcag ttctgctagt
tgggagaatg ctactgtgga 1440cacagatatc atccagggaa ctcaagacca
agcaaagcat cgtttttata ggccccctac 1500acctggacta agaagagtga
gacaaaagaa atctgtgatt ggcagtgtga ccttagtatc 1560tgaaactgag
gttcaagaga aaatgattgg acagttttca tatagtgaag aaagggaaag
1620tggggaaaac aagtctgagt atcacatgtt tacacattct tgcagtaaaa
tgtcatcagt 1680atctaacaaa ccagtacttg ttcagatcaa taacaatgat
caaatggagg agtcatcatt 1740agaaagaaaa aaggaaaaca gtctgcttaa
gtcaagtgca ataagtgctg gtgttataga 1800aattacaagt cagaagatgt
tagagatgtc acataataat ggtttgccat caactatatc 1860aaataactca
attgtggagg aagatgtagt tgattgtgtg gtattggaca acaaaactgg
1920tatcaagaac ttcaaaactt atggtaacac caatgatagg ttcagtccta
tttcagcaga 1980tgcaacccat ttttcaagta ataactctgg aactgacaaa
aatatttctg aggctccagc 2040ttcagaagca tcctctactg tcactgcaag
aattgacaga ctaattaatg aatttgctca 2100gtgtggttta acaaaacttc
caaaaaatga aaagaagatt ttgtcatctg ttgccagcaa 2160aaagaagaaa
aaatctcgac agcaagcaat aaattccagg tatcaagatg gacagcttgc
2220aaccaaagga attcttaata agaatgagag aataaacaca aaaggtagaa
ttacaaagga 2280aatgatagtg caagattcag atagtcccct taaaggaggg
atactttgtg aggaagacct 2340ccagaaaagt gatactgtaa ttgaatcaaa
tactttttgt tccaaaagta atctcaattc 2400cacgatttcc aagaatttcc
atagaaataa attaaatact actcaaaatt ccaaggttca 2460aggactttta
accaaaagaa aatctagatc actaaataaa ataagcttag gagcacctaa
2520aaaaagagaa atcggtcaaa gagataaagt gtttcctcac aatgaatcta
aatattgcaa 2580aagtactttt gaaaacaaaa gtttatttca tgtatttaac
atccttgagc aaaaacccaa 2640agatttttat gcaccgcaat ctcaagcaga
agtggcatct gggtatttga gaggaatggc 2700aaagaagagt ttagtttcaa
aagttactga ttcacacata actttaaaaa gccagaaaaa 2760acgtaaaggg
gataaagtga aagcaagtgc tattttaagt aaacaacatg ctacaaccag
2820ggcaaattct ttagcttctt tgaaaaaacc tgattttcct gaggctattg
ctcatcattc 2880aattcaaaat tatatacaga gttggttgca gaacataaat
ccatatccaa ctttaaagcc 2940tataaaatca gctccagtat gtagaaatga
aacgagtgtg gtaaattgta gcaataatag 3000tttttcaggg aatgatcccc
atacaaattc tggaaaaata agtaattttg ttatggaaag 3060taataagcac
ataactaaaa ttgccggttt gacaggagat aatctatgta aagagggaga
3120taagtctttt attgccaatg acactggtga agaagatctc catgagacac
aggttggatc 3180tctgaatgat gcttatttgg ttcccctgca tgaacactgt
actttgtcac agtcagctat 3240taatgatcat aatactaaaa gtcatatagc
tgctgaaaaa tcaggaccag agaaaaaact 3300tgtttaccag gaaataaacc
tagctagaaa aaggcaaagt gtagaggctg ccattcaagt 3360agatcctata
gaagaggaaa ctccaaaaga cctcttacca gtcctgatgc ttcaccaatt
3420gcaagcttca gttcctggta ttcacaagac tcagaatgga gttgttcaaa
tgccaggttc 3480acttgcaggt gttccctttc attctgcaat atgtaattca
tccactaatc tccttctagc 3540ttggctcttg gtgctaaacc taaagggaag
tatgaatagc ttctgtcaag ttgatgctca 3600caaggctacc aacaaatctt
cagaaacact tgcattgttg gagattctaa agcacatagc 3660tatcacagag
gaagctgatg acttgaaagc tgctgttgcc aatttagtgg agtcaactac
3720aagccacttt ggactcagtg agaaagaaca agacatggtt ccaatagatc
tttctgcaaa 3780ttgttccacg gtcaacattc agagtgttcc taagtgcagt
gaaaatgaaa gaacacaagg 3840aatctcctct ttggatggag gttgctctgc
cagtgaggca tgtgcccctg aagtctgtgt 3900tttggaagtg acttgctctc
catgtgagat gtgcactgta aataaggctt attctccaaa 3960agagacatgt
aaccccagtg acactttttt tcctagtgat ggttatggtg tggatcagac
4020ttctatgaat aaggcttgtt tcctaggaga ggtctgttca cttactgata
ctgtgttttc 4080tgataaggct tgtgctcaaa aggagaacca tacctatgag
ggagcttgcc caattgatga 4140gacctacgtt cctgtcaatg tctgcaatac
cattgacttt ttaaactcca aagaaaacac 4200atatactgat aacttggatt
caactgaaga gttagaaaga ggtgatgaca ttcagaaaga 4260tctaaatatt
ttgacagacc ctgaatataa aaatggattt aatacattgg tgtcacatca
4320aaatgtcagt aatttaagct cctgtggcct ttgcctaagt gaaaaagaag
cagaacttga 4380taagaaacat agttctctag atgattttga aaattgttca
ctaaggaagt ttcaggatga 4440aaatgcatat acttcctttg atatggaaga
accacggact tctgaagaac caggctcaat 4500aaccaacagc atgacatcaa
gtgaaagaaa catttcagaa ttggaatctt ttgaagaatt 4560agaaaaccat
gacactgata tctttaatac agtggtaaat ggaggagagc aagccactga
4620agaattaatc caagaagagg tagaggctag taaaacttta gaattgatag
acatctctag 4680taagaatatt atggaagaaa aaagaatgaa cggtataatt
tatgaaataa tcagtaagag 4740gctggcaaca ccaccatctt tagatttttg
ctatgattct aagcaaaata gtgaaaagga 4800gaccaatgaa ggagaaacta
agatggtaaa aatgatggtg aaaactatgg aaactggaag 4860ttattcagag
tcctctcctg atttaaaaaa atgcatcaaa agtccagtga cttctgattg
4920gtcagactat cggcctgaca gtgacagtga gcagccatat aaaacatcca
gtgatgatcc 4980caatgacagt ggcgaactta cccaagagaa agaatataac
ataggatttg ttaaaagggc 5040aatagaaaaa ctgtacggta aagcagatat
tatcaaacca tctttttttc ctgggtctac 5100ccgcaaatct caggtttgtc
cttataattc tgtggaattt cagtgttcca ggaaagcaag 5160tctttatgat
tctgaagggc agtcatttgg ctcttctgaa caggtatcta gtagttcatc
5220tatgttgcag gaattccagg aggaaagaca agataagtgt gatgttagtg
ctgtgaggga 5280caattattgt aggggtgaca ttgtagaacc tggtacaaaa
caaaatgatg atagcagaat 5340cctcacagac atagaggaag gagtactgat
tgacaaaggc
aaatggcttc tgaaagaaaa 5400tcatttgcta aggatgtcat ctgaaaatcc
tggcatgtgt ggcaatgcag acaccacatc 5460agtggacacc ctacttgata
ataacagcag tgaggtacca tattcacatt ttggtaattt 5520ggccccaggc
ccaacgatgg atgaactctc ctcttcagaa ctcgaggaac tgactcaacc
5580ccttgaacta aaatgcaatt actttaacat gcctcatggt agtgactcag
aaccttttca 5640tgaggacttg ctggatgttc gcaatgaaac ctgtgccaag
gaaagaatag caaatcatca 5700tacagaggag aagggtagtc atcagtcaga
aagagtatgc acatctgtca ctcattcctt 5760tatttctgct ggtaacaaag
tctaccctgt ctctgatgat gctattaaaa accaaccatt 5820gcctggcagt
aatatgattc atggtacact tcaggaagct gactctttgg ataaactgta
5880tgctctttgt ggtcaacatt gcccaatact aactgttatt atccaaccca
tgaatgagga 5940agaccgagga tttgcatatc gcaaagaatc tgatattgaa
aatttcttgg gtttttattt 6000atggatgaaa atacacccat atttacttca
gacagacaaa aatgtgttca gggaagagaa 6060caataaagca agtatgagac
aaaatcttat tgataatgcc attggtgata tatttgatca 6120gttttatttc
agtaacacat ttgacttgat gggtaaaaga agaaaacaaa aaagaattaa
6180cttcttgggg ttagaggaag aaggtaattt aaagaaattt caaccagatt
tgaaggaaag 6240gttttgtatg aatttcttgc acacatcatt gttagttgtg
ggtaatgtgg attcaaatac 6300acaagacctc agcggtcaga caaatgaaat
ctttaaagca gtcgatgaga ataacaactt 6360attaaataac agattccagg
gctcaagaac aaatctcaac caagtagtaa gagaaaatat 6420caactgtcat
tacttctttg aaatgcttgg tcaagcttgc ctcttagata tttgccaagt
6480tgagacctcc ttaaatatta gcaacagaaa tattttagaa ctttgtatgt
ttgagggtga 6540aaatcttttc atttgggaag aggaagacat attaaattta
actgatcttg aaagcagtag 6600agaacaagaa gatttataat ttcaatatca
gcacactcat tctttgtcaa ttcatttttt 6660cccatgagat gaagcacatg
tgacgaatac ggactagata acctctaaga attttccact 6720tcttcaaaat
gaacttactc tagaaagctt acccttggat aaccagtttg actttcataa
6780tgtctctgtt ttttgttttt ccaacaatta cagactcagg ttctcttatt
ttggaagttt 6840ctatctggtt ttgttctgaa cttacatttt tttttttttt
ggtatctatg attttttttg 6900ctcagggcat caaaatgtgc taaggacaag
aattatatcc tttttaaaaa atgttgttag 6960cttggtgtaa aatgtatatt
gactgtattg gtgaataaat tgaatagaca taacctcaaa 7020gtacttcact
tattcttttt aactactgat ttgataaaaa gtatgattat aagatatcca
7080cgacaatctc atagtttctt 7100352156PRTHomo sapiens 35Met Ser Asp
Thr Pro Ser Thr Gly Phe Ser Ile Ile His Pro Thr Ser 1 5 10 15 Ser
Glu Gly Gln Val Pro Pro Pro Arg His Leu Ser Leu Thr His Pro 20 25
30 Val Val Ala Lys Arg Ile Ser Phe Tyr Lys Ser Gly Asp Pro Gln Phe
35 40 45 Gly Gly Val Arg Val Val Val Asn Pro Arg Ser Phe Lys Ser
Phe Asp 50 55 60 Ala Leu Leu Asp Asn Leu Ser Arg Lys Val Pro Leu
Pro Phe Gly Val 65 70 75 80 Arg Asn Ile Ser Thr Pro Arg Gly Arg His
Ser Ile Thr Arg Leu Glu 85 90 95 Glu Leu Glu Asp Gly Glu Ser Tyr
Leu Cys Ser His Gly Arg Lys Val 100 105 110 Gln Pro Val Asp Leu Asp
Lys Ala Arg Arg Arg Pro Arg Pro Trp Leu 115 120 125 Ser Ser Arg Ala
Ile Ser Ala His Ser Pro Pro His Pro Val Ala Val 130 135 140 Ala Ala
Pro Gly Met Pro Arg Pro Pro Arg Ser Leu Val Val Phe Arg 145 150 155
160 Asn Gly Asp Pro Lys Thr Arg Arg Ala Val Leu Leu Ser Arg Arg Val
165 170 175 Thr Gln Ser Phe Glu Ala Phe Leu Gln His Leu Thr Glu Val
Met Gln 180 185 190 Arg Pro Val Val Lys Leu Tyr Ala Thr Asp Gly Arg
Arg Val Pro Ser 195 200 205 Leu Gln Ala Val Ile Leu Ser Ser Gly Ala
Val Val Ala Ala Gly Arg 210 215 220 Glu Pro Phe Lys Pro Gly Asn Tyr
Asp Ile Gln Lys Tyr Leu Leu Pro 225 230 235 240 Ala Arg Leu Pro Gly
Ile Ser Gln Arg Val Tyr Pro Lys Gly Asn Ala 245 250 255 Lys Ser Glu
Ser Arg Lys Ile Ser Thr His Met Ser Ser Ser Ser Arg 260 265 270 Ser
Gln Ile Tyr Ser Val Ser Ser Glu Lys Thr His Asn Asn Asp Cys 275 280
285 Tyr Leu Asp Tyr Ser Phe Val Pro Glu Lys Tyr Leu Ala Leu Glu Lys
290 295 300 Asn Asp Ser Gln Asn Leu Pro Ile Tyr Pro Ser Glu Asp Asp
Ile Glu 305 310 315 320 Lys Ser Ile Ile Phe Asn Gln Asp Gly Thr Met
Thr Val Glu Met Lys 325 330 335 Val Arg Phe Arg Ile Lys Glu Glu Glu
Thr Ile Lys Trp Thr Thr Thr 340 345 350 Val Ser Lys Thr Gly Pro Ser
Asn Asn Asp Glu Lys Ser Glu Met Ser 355 360 365 Phe Pro Gly Arg Thr
Glu Ser Arg Ser Ser Gly Leu Lys Leu Ala Ala 370 375 380 Cys Ser Phe
Ser Ala Asp Val Ser Pro Met Glu Arg Ser Ser Asn Gln 385 390 395 400
Glu Gly Ser Leu Ala Glu Glu Ile Asn Ile Gln Met Thr Asp Gln Val 405
410 415 Ala Glu Thr Cys Ser Ser Ala Ser Trp Glu Asn Ala Thr Val Asp
Thr 420 425 430 Asp Ile Ile Gln Gly Thr Gln Asp Gln Ala Lys His Arg
Phe Tyr Arg 435 440 445 Pro Pro Thr Pro Gly Leu Arg Arg Val Arg Gln
Lys Lys Ser Val Ile 450 455 460 Gly Ser Val Thr Leu Val Ser Glu Thr
Glu Val Gln Glu Lys Met Ile 465 470 475 480 Gly Gln Phe Ser Tyr Ser
Glu Glu Arg Glu Ser Gly Glu Asn Lys Ser 485 490 495 Glu Tyr His Met
Phe Thr His Ser Cys Ser Lys Met Ser Ser Val Ser 500 505 510 Asn Lys
Pro Val Leu Val Gln Ile Asn Asn Asn Asp Gln Met Glu Glu 515 520 525
Ser Ser Leu Glu Arg Lys Lys Glu Asn Ser Leu Leu Lys Ser Ser Ala 530
535 540 Ile Ser Ala Gly Val Ile Glu Ile Thr Ser Gln Lys Met Leu Glu
Met 545 550 555 560 Ser His Asn Asn Gly Leu Pro Ser Thr Ile Ser Asn
Asn Ser Ile Val 565 570 575 Glu Glu Asp Val Val Asp Cys Val Val Leu
Asp Asn Lys Thr Gly Ile 580 585 590 Lys Asn Phe Lys Thr Tyr Gly Asn
Thr Asn Asp Arg Phe Ser Pro Ile 595 600 605 Ser Ala Asp Ala Thr His
Phe Ser Ser Asn Asn Ser Gly Thr Asp Lys 610 615 620 Asn Ile Ser Glu
Ala Pro Ala Ser Glu Ala Ser Ser Thr Val Thr Ala 625 630 635 640 Arg
Ile Asp Arg Leu Ile Asn Glu Phe Ala Gln Cys Gly Leu Thr Lys 645 650
655 Leu Pro Lys Asn Glu Lys Lys Ile Leu Ser Ser Val Ala Ser Lys Lys
660 665 670 Lys Lys Lys Ser Arg Gln Gln Ala Ile Asn Ser Arg Tyr Gln
Asp Gly 675 680 685 Gln Leu Ala Thr Lys Gly Ile Leu Asn Lys Asn Glu
Arg Ile Asn Thr 690 695 700 Lys Gly Arg Ile Thr Lys Glu Met Ile Val
Gln Asp Ser Asp Ser Pro 705 710 715 720 Leu Lys Gly Gly Ile Leu Cys
Glu Glu Asp Leu Gln Lys Ser Asp Thr 725 730 735 Val Ile Glu Ser Asn
Thr Phe Cys Ser Lys Ser Asn Leu Asn Ser Thr 740 745 750 Ile Ser Lys
Asn Phe His Arg Asn Lys Leu Asn Thr Thr Gln Asn Ser 755 760 765 Lys
Val Gln Gly Leu Leu Thr Lys Arg Lys Ser Arg Ser Leu Asn Lys 770 775
780 Ile Ser Leu Gly Ala Pro Lys Lys Arg Glu Ile Gly Gln Arg Asp Lys
785 790 795 800 Val Phe Pro His Asn Glu Ser Lys Tyr Cys Lys Ser Thr
Phe Glu Asn 805 810 815 Lys Ser Leu Phe His Val Phe Asn Ile Leu Glu
Gln Lys Pro Lys Asp 820 825 830 Phe Tyr Ala Pro Gln Ser Gln Ala Glu
Val Ala Ser Gly Tyr Leu Arg 835 840 845 Gly Met Ala Lys Lys Ser Leu
Val Ser Lys Val Thr Asp Ser His Ile 850 855 860 Thr Leu Lys Ser Gln
Lys Lys Arg Lys Gly Asp Lys Val Lys Ala Ser 865 870 875 880 Ala Ile
Leu Ser Lys Gln His Ala Thr Thr Arg Ala Asn Ser Leu Ala 885 890 895
Ser Leu Lys Lys Pro Asp Phe Pro Glu Ala Ile Ala His His Ser Ile 900
905 910 Gln Asn Tyr Ile Gln Ser Trp Leu Gln Asn Ile Asn Pro Tyr Pro
Thr 915 920 925 Leu Lys Pro Ile Lys Ser Ala Pro Val Cys Arg Asn Glu
Thr Ser Val 930 935 940 Val Asn Cys Ser Asn Asn Ser Phe Ser Gly Asn
Asp Pro His Thr Asn 945 950 955 960 Ser Gly Lys Ile Ser Asn Phe Val
Met Glu Ser Asn Lys His Ile Thr 965 970 975 Lys Ile Ala Gly Leu Thr
Gly Asp Asn Leu Cys Lys Glu Gly Asp Lys 980 985 990 Ser Phe Ile Ala
Asn Asp Thr Gly Glu Glu Asp Leu His Glu Thr Gln 995 1000 1005 Val
Gly Ser Leu Asn Asp Ala Tyr Leu Val Pro Leu His Glu His 1010 1015
1020 Cys Thr Leu Ser Gln Ser Ala Ile Asn Asp His Asn Thr Lys Ser
1025 1030 1035 His Ile Ala Ala Glu Lys Ser Gly Pro Glu Lys Lys Leu
Val Tyr 1040 1045 1050 Gln Glu Ile Asn Leu Ala Arg Lys Arg Gln Ser
Val Glu Ala Ala 1055 1060 1065 Ile Gln Val Asp Pro Ile Glu Glu Glu
Thr Pro Lys Asp Leu Leu 1070 1075 1080 Pro Val Leu Met Leu His Gln
Leu Gln Ala Ser Val Pro Gly Ile 1085 1090 1095 His Lys Thr Gln Asn
Gly Val Val Gln Met Pro Gly Ser Leu Ala 1100 1105 1110 Gly Val Pro
Phe His Ser Ala Ile Cys Asn Ser Ser Thr Asn Leu 1115 1120 1125 Leu
Leu Ala Trp Leu Leu Val Leu Asn Leu Lys Gly Ser Met Asn 1130 1135
1140 Ser Phe Cys Gln Val Asp Ala His Lys Ala Thr Asn Lys Ser Ser
1145 1150 1155 Glu Thr Leu Ala Leu Leu Glu Ile Leu Lys His Ile Ala
Ile Thr 1160 1165 1170 Glu Glu Ala Asp Asp Leu Lys Ala Ala Val Ala
Asn Leu Val Glu 1175 1180 1185 Ser Thr Thr Ser His Phe Gly Leu Ser
Glu Lys Glu Gln Asp Met 1190 1195 1200 Val Pro Ile Asp Leu Ser Ala
Asn Cys Ser Thr Val Asn Ile Gln 1205 1210 1215 Ser Val Pro Lys Cys
Ser Glu Asn Glu Arg Thr Gln Gly Ile Ser 1220 1225 1230 Ser Leu Asp
Gly Gly Cys Ser Ala Ser Glu Ala Cys Ala Pro Glu 1235 1240 1245 Val
Cys Val Leu Glu Val Thr Cys Ser Pro Cys Glu Met Cys Thr 1250 1255
1260 Val Asn Lys Ala Tyr Ser Pro Lys Glu Thr Cys Asn Pro Ser Asp
1265 1270 1275 Thr Phe Phe Pro Ser Asp Gly Tyr Gly Val Asp Gln Thr
Ser Met 1280 1285 1290 Asn Lys Ala Cys Phe Leu Gly Glu Val Cys Ser
Leu Thr Asp Thr 1295 1300 1305 Val Phe Ser Asp Lys Ala Cys Ala Gln
Lys Glu Asn His Thr Tyr 1310 1315 1320 Glu Gly Ala Cys Pro Ile Asp
Glu Thr Tyr Val Pro Val Asn Val 1325 1330 1335 Cys Asn Thr Ile Asp
Phe Leu Asn Ser Lys Glu Asn Thr Tyr Thr 1340 1345 1350 Asp Asn Leu
Asp Ser Thr Glu Glu Leu Glu Arg Gly Asp Asp Ile 1355 1360 1365 Gln
Lys Asp Leu Asn Ile Leu Thr Asp Pro Glu Tyr Lys Asn Gly 1370 1375
1380 Phe Asn Thr Leu Val Ser His Gln Asn Val Ser Asn Leu Ser Ser
1385 1390 1395 Cys Gly Leu Cys Leu Ser Glu Lys Glu Ala Glu Leu Asp
Lys Lys 1400 1405 1410 His Ser Ser Leu Asp Asp Phe Glu Asn Cys Ser
Leu Arg Lys Phe 1415 1420 1425 Gln Asp Glu Asn Ala Tyr Thr Ser Phe
Asp Met Glu Glu Pro Arg 1430 1435 1440 Thr Ser Glu Glu Pro Gly Ser
Ile Thr Asn Ser Met Thr Ser Ser 1445 1450 1455 Glu Arg Asn Ile Ser
Glu Leu Glu Ser Phe Glu Glu Leu Glu Asn 1460 1465 1470 His Asp Thr
Asp Ile Phe Asn Thr Val Val Asn Gly Gly Glu Gln 1475 1480 1485 Ala
Thr Glu Glu Leu Ile Gln Glu Glu Val Glu Ala Ser Lys Thr 1490 1495
1500 Leu Glu Leu Ile Asp Ile Ser Ser Lys Asn Ile Met Glu Glu Lys
1505 1510 1515 Arg Met Asn Gly Ile Ile Tyr Glu Ile Ile Ser Lys Arg
Leu Ala 1520 1525 1530 Thr Pro Pro Ser Leu Asp Phe Cys Tyr Asp Ser
Lys Gln Asn Ser 1535 1540 1545 Glu Lys Glu Thr Asn Glu Gly Glu Thr
Lys Met Val Lys Met Met 1550 1555 1560 Val Lys Thr Met Glu Thr Gly
Ser Tyr Ser Glu Ser Ser Pro Asp 1565 1570 1575 Leu Lys Lys Cys Ile
Lys Ser Pro Val Thr Ser Asp Trp Ser Asp 1580 1585 1590 Tyr Arg Pro
Asp Ser Asp Ser Glu Gln Pro Tyr Lys Thr Ser Ser 1595 1600 1605 Asp
Asp Pro Asn Asp Ser Gly Glu Leu Thr Gln Glu Lys Glu Tyr 1610 1615
1620 Asn Ile Gly Phe Val Lys Arg Ala Ile Glu Lys Leu Tyr Gly Lys
1625 1630 1635 Ala Asp Ile Ile Lys Pro Ser Phe Phe Pro Gly Ser Thr
Arg Lys 1640 1645 1650 Ser Gln Val Cys Pro Tyr Asn Ser Val Glu Phe
Gln Cys Ser Arg 1655 1660 1665 Lys Ala Ser Leu Tyr Asp Ser Glu Gly
Gln Ser Phe Gly Ser Ser 1670 1675 1680 Glu Gln Val Ser Ser Ser Ser
Ser Met Leu Gln Glu Phe Gln Glu 1685 1690 1695 Glu Arg Gln Asp Lys
Cys Asp Val Ser Ala Val Arg Asp Asn Tyr 1700 1705 1710 Cys Arg Gly
Asp Ile Val Glu Pro Gly Thr Lys Gln Asn Asp Asp 1715 1720 1725 Ser
Arg Ile Leu Thr Asp Ile Glu Glu Gly Val Leu Ile Asp Lys 1730 1735
1740 Gly Lys Trp Leu Leu Lys Glu Asn His Leu Leu Arg Met Ser Ser
1745 1750 1755 Glu Asn Pro Gly Met Cys Gly Asn Ala Asp Thr Thr Ser
Val Asp 1760 1765 1770 Thr Leu Leu Asp Asn Asn Ser Ser Glu Val Pro
Tyr Ser His Phe 1775 1780 1785 Gly Asn Leu Ala Pro Gly Pro Thr Met
Asp Glu Leu Ser Ser Ser 1790 1795 1800 Glu Leu Glu Glu Leu Thr Gln
Pro Leu Glu Leu Lys Cys Asn Tyr 1805 1810 1815 Phe Asn Met Pro His
Gly Ser Asp Ser Glu Pro Phe His Glu Asp 1820 1825 1830 Leu Leu Asp
Val Arg Asn Glu Thr Cys Ala Lys Glu Arg Ile Ala 1835 1840 1845 Asn
His His Thr Glu Glu Lys Gly Ser His Gln Ser Glu Arg Val 1850 1855
1860 Cys Thr Ser Val Thr His Ser Phe Ile Ser Ala Gly Asn Lys Val
1865 1870 1875 Tyr Pro Val Ser Asp Asp Ala Ile Lys Asn Gln Pro Leu
Pro Gly 1880 1885 1890 Ser Asn Met Ile His Gly Thr Leu Gln Glu Ala
Asp Ser Leu Asp 1895 1900 1905 Lys Leu Tyr Ala Leu Cys Gly Gln His
Cys Pro Ile Leu Thr Val 1910 1915 1920 Ile Ile Gln Pro Met Asn Glu
Glu Asp Arg Gly Phe Ala Tyr Arg 1925 1930 1935 Lys Glu Ser Asp Ile
Glu Asn Phe Leu Gly Phe Tyr Leu Trp Met 1940 1945 1950 Lys Ile His
Pro Tyr Leu Leu Gln Thr Asp Lys Asn Val Phe Arg 1955 1960 1965 Glu
Glu Asn Asn Lys Ala Ser Met Arg Gln Asn Leu Ile Asp Asn 1970 1975
1980 Ala Ile
Gly Asp Ile Phe Asp Gln Phe Tyr Phe Ser Asn Thr Phe 1985 1990 1995
Asp Leu Met Gly Lys Arg Arg Lys Gln Lys Arg Ile Asn Phe Leu 2000
2005 2010 Gly Leu Glu Glu Glu Gly Asn Leu Lys Lys Phe Gln Pro Asp
Leu 2015 2020 2025 Lys Glu Arg Phe Cys Met Asn Phe Leu His Thr Ser
Leu Leu Val 2030 2035 2040 Val Gly Asn Val Asp Ser Asn Thr Gln Asp
Leu Ser Gly Gln Thr 2045 2050 2055 Asn Glu Ile Phe Lys Ala Val Asp
Glu Asn Asn Asn Leu Leu Asn 2060 2065 2070 Asn Arg Phe Gln Gly Ser
Arg Thr Asn Leu Asn Gln Val Val Arg 2075 2080 2085 Glu Asn Ile Asn
Cys His Tyr Phe Phe Glu Met Leu Gly Gln Ala 2090 2095 2100 Cys Leu
Leu Asp Ile Cys Gln Val Glu Thr Ser Leu Asn Ile Ser 2105 2110 2115
Asn Arg Asn Ile Leu Glu Leu Cys Met Phe Glu Gly Glu Asn Leu 2120
2125 2130 Phe Ile Trp Glu Glu Glu Asp Ile Leu Asn Leu Thr Asp Leu
Glu 2135 2140 2145 Ser Ser Arg Glu Gln Glu Asp Leu 2150 2155
363950DNAHomo sapiens 36atgtcacatc tggtggaccc tacatcagga gacttgccag
ttagagacat agatgctata 60cctctggtgc taccagcctc aaaaggtaag aatatgaaaa
ctcaaccacc cttgagcagg 120atgaaccggg aggaattgga ggacagtttc
tttcgacttc gcgaagatca catgttggtg 180aaggagcttt cttggaagca
acaggatgag atcaaaaggc tgaggaccac cttgctgcgg 240ttgaccgctg
ctggccggga cctgcgggtc gcggaggagg cggcgccgct ctcggagacc
300gcaaggcgcg ggcagaaggc gggatggcgg cagcgcctct ccatgcacca
gcgcccccag 360atgcaccgac tgcaagggca tttccactgc gtcggccctg
ccagcccccg ccgcgcccag 420cctcgcgtcc aagtgggaca cagacagctc
cacacagccg gtgcaccggt gccggagaaa 480cccaagaggg ggccaaggga
caggctgagc tacacagccc ctccatcgtt taaggagcat 540gcgacaaatg
aaaacagagg tgaagtagcc agtaaaccca gtgaacttgt ttctggttct
600aacagcataa tttctttcag cagtgtcata agtatggcta aacccattgg
tctatgcatg 660cctaacagtg cccacatcat ggccagcaat accatgcaag
tggaagagcc acccaagtct 720cctgagaaaa tgtggcctaa agatgaaaat
tttgaacaga gaagctcatt ggagtgtgct 780cagaaggctg cagagcttcg
agcttccatt aaagagaagg tagagctgat tcgacttaag 840aagctcttac
atgaaagaaa tgcttcattg gttatgacaa aagcacaatt aacagaagtt
900caagaggcat acgaaacctt gctccagaag aatcagggaa tcctgagtgc
agcccatgag 960gccctcctca agcaagtgaa tgagctcagg gcagagctga
aggaagaaag caagaaggct 1020gtgagcttga agagccaact ggaagatgtg
tctatcttgc agatgactct gaaggagttt 1080caggagagag ttgaagattt
ggaaaaagaa cgaaaattgc tgaatgacaa ttatgacaaa 1140ctcttagaaa
gcatgctgga cagcagtgac agctccagtc agccccactg gagcaacgag
1200ctcatagcgg aacagctaca gcagcaagtc tctcagctgc aggatcagct
ggatgctgag 1260ctggaggaca agagaaaagt tttacttgag ctgtccaggg
agaaagccca aaatgaggat 1320ctgaagcttg aagtcaccaa catacttcag
aagcataaac aggaagtaga gctcctccaa 1380aatgcagcca caatttccca
acctcctgac aggcaatctg aaccagccac tcacccagct 1440gtattgcaag
agaacactca gatcgagcca agtgaaccca aaaaccaaga agaaaagaaa
1500ctgtcccagg tgctaaatga gttgcaagta tcacacgcag agaccacatt
ggaactagaa 1560aagaccaggg acatgcttat tctgcagcgc aaaatcaacg
tgtgttatca ggaggaactg 1620gaggcaatga tgacaaaagc tgacaatgat
aatagagatc acaaagaaaa gctggagagg 1680ttgactcgac tactagacct
caagaataac cgtatcaagc agctggaagg tattttaaga 1740agccatgacc
ttccaacatc tgaacagctc aaagatgttg cttatggcac ccgaccgttg
1800tcgttatgtt tggaaacact gccagcccat ggagatgagg ataaagtgga
tatttctctg 1860ctgcatcagg gtgagaatct ttttgaactg cacatccacc
aggccttcct gacatctgcc 1920gccctagctc aggctggaga tacccaacct
accactttct gcacctattc cttctatgac 1980tttgaaaccc actgtacccc
attatctgtg gggccacagc ccctctatga cttcacctcc 2040cagtatgtga
tggagacaga ttcgcttttc ttacactacc ttcaagaggc ttcagcccgg
2100cttgacatac accaggccat ggccagtgaa cacagcactc ttgctgcagg
atggatttgc 2160tttgacaggg tgctagagac tgtggagaaa gtccatggct
tggccacact gattggagct 2220ggtggagaag agttcggggt tctagagtac
tggatgaggc tgcgtttccc cataaaaccc 2280agcctacagg cgtgcaataa
acgaaagaaa gcccaggtct acctgtcaac cgatgtgctt 2340ggaggccgga
aggcccagga agaggagttc agatcggagt cttgggaacc tcagaacgag
2400ctgtggattg aaatcaccaa gtgctgtggc ctccggagtc gatggctggg
aactcaaccc 2460agtccatatg ctgtgtaccg cttcttcacc ttttctgacc
atgacactgc catcattcca 2520gccagtaaca acccctactt tagagaccag
gctcgattcc cagtgcttgt gacctctgac 2580ctggaccatt atctgagacg
ggaggccttg tctatacatg tttttgatga tgaagactta 2640gagcctggct
cgtatcttgg ccgagcccga gtgcctttac tgcctcttgc aaaaaatgaa
2700tctatcaaag gtgattttaa cctcactgac cctgcagaga aacccaacgg
atctattcaa 2760gtgcaactgg attggaagtt tccctacata ccccctgaga
gcttcctgaa accagaagct 2820cagactaagg ggaaggatac caaggacagt
tcaaagatct catctgaaga ggaaaaggct 2880tcatttcctt cccaggatca
gatggcatct cctgaggttc ccattgaagc tggccagtat 2940cgatctaaga
gaaaacctcc tcatggggga gaaagaaagg agaaggagca ccaggttgtg
3000agctactcaa gaagaaaaca tggcaaaaga ataggtgttc aaggaaagaa
tagaatggag 3060tatcttagcc ttaacatctt aaatggaaat acaccagagc
aggtgaatta cactgagtgg 3120aagttctcag agactaacag cttcataggt
gatggcttta aaaatcagca cgaggaagag 3180gaaatgacat tatcccattc
agcactgaaa cagaaggaac ctctacatcc tgtaaatgac 3240aaagaatcct
ctgaacaagg ttctgaagtc agtgaagcac aaactaccga cagtgatgat
3300gtcatagtgc cacccatgtc tcagaaatat cctaaggcag attcagagaa
gatgtgcatt 3360gaaattgtct ccctggcctt ctacccagag gcagaagtga
tgtctgatga gaacataaaa 3420caggtgtatg tggagtacaa attctacgac
ctacccttgt cggagacaga gactccagtg 3480tccctaagga agcctagggc
aggagaagaa atccactttc actttagcaa ggtaatagac 3540ctggacccac
aggagcagca aggccgaagg cggtttctgt tcgacatgct gaatggacaa
3600gatcctgatc aaggacattt aaagtttaca gtggtaagtg atcctctgga
tgaagaaaag 3660aaagaatgtg aagaagtggg atatgcatat cttcaactgt
ggcagatcct ggagtcagga 3720agagatattc tagagcaaga gctagacatt
gttagccctg aagatctggc taccccaata 3780ggaaggctga aggtttccct
tcaagcagct gctgtcctcc atgctattta caaggagatg 3840actgaagatt
tgttttcatg aaggaacaag tgctattcca atctaaaagt ctctgaggga
3900accatagtaa aaagtctctt ataaagttag cttgctataa catgaaaaaa
3950371286PRTHomo sapiens 37Met Ser His Leu Val Asp Pro Thr Ser Gly
Asp Leu Pro Val Arg Asp 1 5 10 15 Ile Asp Ala Ile Pro Leu Val Leu
Pro Ala Ser Lys Gly Lys Asn Met 20 25 30 Lys Thr Gln Pro Pro Leu
Ser Arg Met Asn Arg Glu Glu Leu Glu Asp 35 40 45 Ser Phe Phe Arg
Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser 50 55 60 Trp Lys
Gln Gln Asp Glu Ile Lys Arg Leu Arg Thr Thr Leu Leu Arg 65 70 75 80
Leu Thr Ala Ala Gly Arg Asp Leu Arg Val Ala Glu Glu Ala Ala Pro 85
90 95 Leu Ser Glu Thr Ala Arg Arg Gly Gln Lys Ala Gly Trp Arg Gln
Arg 100 105 110 Leu Ser Met His Gln Arg Pro Gln Met His Arg Leu Gln
Gly His Phe 115 120 125 His Cys Val Gly Pro Ala Ser Pro Arg Arg Ala
Gln Pro Arg Val Gln 130 135 140 Val Gly His Arg Gln Leu His Thr Ala
Gly Ala Pro Val Pro Glu Lys 145 150 155 160 Pro Lys Arg Gly Pro Arg
Asp Arg Leu Ser Tyr Thr Ala Pro Pro Ser 165 170 175 Phe Lys Glu His
Ala Thr Asn Glu Asn Arg Gly Glu Val Ala Ser Lys 180 185 190 Pro Ser
Glu Leu Val Ser Gly Ser Asn Ser Ile Ile Ser Phe Ser Ser 195 200 205
Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala 210
215 220 His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys
Ser 225 230 235 240 Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu
Gln Arg Ser Ser 245 250 255 Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu
Arg Ala Ser Ile Lys Glu 260 265 270 Lys Val Glu Leu Ile Arg Leu Lys
Lys Leu Leu His Glu Arg Asn Ala 275 280 285 Ser Leu Val Met Thr Lys
Ala Gln Leu Thr Glu Val Gln Glu Ala Tyr 290 295 300 Glu Thr Leu Leu
Gln Lys Asn Gln Gly Ile Leu Ser Ala Ala His Glu 305 310 315 320 Ala
Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu 325 330
335 Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile
340 345 350 Leu Gln Met Thr Leu Lys Glu Phe Gln Glu Arg Val Glu Asp
Leu Glu 355 360 365 Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys
Leu Leu Glu Ser 370 375 380 Met Leu Asp Ser Ser Asp Ser Ser Ser Gln
Pro His Trp Ser Asn Glu 385 390 395 400 Leu Ile Ala Glu Gln Leu Gln
Gln Gln Val Ser Gln Leu Gln Asp Gln 405 410 415 Leu Asp Ala Glu Leu
Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser 420 425 430 Arg Glu Lys
Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile 435 440 445 Leu
Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr 450 455
460 Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala
465 470 475 480 Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro
Lys Asn Gln 485 490 495 Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu
Leu Gln Val Ser His 500 505 510 Ala Glu Thr Thr Leu Glu Leu Glu Lys
Thr Arg Asp Met Leu Ile Leu 515 520 525 Gln Arg Lys Ile Asn Val Cys
Tyr Gln Glu Glu Leu Glu Ala Met Met 530 535 540 Thr Lys Ala Asp Asn
Asp Asn Arg Asp His Lys Glu Lys Leu Glu Arg 545 550 555 560 Leu Thr
Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu 565 570 575
Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu Gln Leu Lys Asp 580
585 590 Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu
Pro 595 600 605 Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu
His Gln Gly 610 615 620 Glu Asn Leu Phe Glu Leu His Ile His Gln Ala
Phe Leu Thr Ser Ala 625 630 635 640 Ala Leu Ala Gln Ala Gly Asp Thr
Gln Pro Thr Thr Phe Cys Thr Tyr 645 650 655 Ser Phe Tyr Asp Phe Glu
Thr His Cys Thr Pro Leu Ser Val Gly Pro 660 665 670 Gln Pro Leu Tyr
Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser 675 680 685 Leu Phe
Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His 690 695 700
Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys 705
710 715 720 Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu
Ala Thr 725 730 735 Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly Val Leu
Glu Tyr Trp Met 740 745 750 Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu
Gln Ala Cys Asn Lys Arg 755 760 765 Lys Lys Ala Gln Val Tyr Leu Ser
Thr Asp Val Leu Gly Gly Arg Lys 770 775 780 Ala Gln Glu Glu Glu Phe
Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu 785 790 795 800 Leu Trp Ile
Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu 805 810 815 Gly
Thr Gln Pro Ser Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser 820 825
830 Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg
835 840 845 Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp
His Tyr 850 855 860 Leu Arg Arg Glu Ala Leu Ser Ile His Val Phe Asp
Asp Glu Asp Leu 865 870 875 880 Glu Pro Gly Ser Tyr Leu Gly Arg Ala
Arg Val Pro Leu Leu Pro Leu 885 890 895 Ala Lys Asn Glu Ser Ile Lys
Gly Asp Phe Asn Leu Thr Asp Pro Ala 900 905 910 Glu Lys Pro Asn Gly
Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro 915 920 925 Tyr Ile Pro
Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly 930 935 940 Lys
Asp Thr Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala 945 950
955 960 Ser Phe Pro Ser Gln Asp Gln Met Ala Ser Pro Glu Val Pro Ile
Glu 965 970 975 Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro Pro His Gly
Gly Glu Arg 980 985 990 Lys Glu Lys Glu His Gln Val Val Ser Tyr Ser
Arg Arg Lys His Gly 995 1000 1005 Lys Arg Ile Gly Val Gln Gly Lys
Asn Arg Met Glu Tyr Leu Ser 1010 1015 1020 Leu Asn Ile Leu Asn Gly
Asn Thr Pro Glu Gln Val Asn Tyr Thr 1025 1030 1035 Glu Trp Lys Phe
Ser Glu Thr Asn Ser Phe Ile Gly Asp Gly Phe 1040 1045 1050 Lys Asn
Gln His Glu Glu Glu Glu Met Thr Leu Ser His Ser Ala 1055 1060 1065
Leu Lys Gln Lys Glu Pro Leu His Pro Val Asn Asp Lys Glu Ser 1070
1075 1080 Ser Glu Gln Gly Ser Glu Val Ser Glu Ala Gln Thr Thr Asp
Ser 1085 1090 1095 Asp Asp Val Ile Val Pro Pro Met Ser Gln Lys Tyr
Pro Lys Ala 1100 1105 1110 Asp Ser Glu Lys Met Cys Ile Glu Ile Val
Ser Leu Ala Phe Tyr 1115 1120 1125 Pro Glu Ala Glu Val Met Ser Asp
Glu Asn Ile Lys Gln Val Tyr 1130 1135 1140 Val Glu Tyr Lys Phe Tyr
Asp Leu Pro Leu Ser Glu Thr Glu Thr 1145 1150 1155 Pro Val Ser Leu
Arg Lys Pro Arg Ala Gly Glu Glu Ile His Phe 1160 1165 1170 His Phe
Ser Lys Val Ile Asp Leu Asp Pro Gln Glu Gln Gln Gly 1175 1180 1185
Arg Arg Arg Phe Leu Phe Asp Met Leu Asn Gly Gln Asp Pro Asp 1190
1195 1200 Gln Gly His Leu Lys Phe Thr Val Val Ser Asp Pro Leu Asp
Glu 1205 1210 1215 Glu Lys Lys Glu Cys Glu Glu Val Gly Tyr Ala Tyr
Leu Gln Leu 1220 1225 1230 Trp Gln Ile Leu Glu Ser Gly Arg Asp Ile
Leu Glu Gln Glu Leu 1235 1240 1245 Asp Ile Val Ser Pro Glu Asp Leu
Ala Thr Pro Ile Gly Arg Leu 1250 1255 1260 Lys Val Ser Leu Gln Ala
Ala Ala Val Leu His Ala Ile Tyr Lys 1265 1270 1275 Glu Met Thr Glu
Asp Leu Phe Ser 1280 1285 387221DNAHomo sapiens 38cgggcggcct
cttgtgtgag ggcctgtggg attctccgga tatggccgga gtgtttcctt 60atcgagggcc
gggtaacccg gtgcctggcc ctctagcccc gctaccggac tacatgtcgg
120aggagaagct gcaggagaaa gctcgaaaat ggcagcaatt gcaggccaag
cgctatgcag 180aaaagcggaa gtttgggttt gtggatgccc agaaggaaga
catgccccca gaacatgtca 240gggagatcat tcgagaccat ggagacatga
ccaacaggaa gttccgccat gacaaaaggg 300tttacttggg tgccctaaag
tacatgcccc acgcagtcct caaactcctg gagaacatgc 360ctatgccttg
ggagcagatt cgggatgtgc ccgtgctgta ccacatcact ggagccattt
420ccttcgtcaa tgagattccc tgggtcattg aacctgtcta catctcccag
tgggggtcaa 480tgtggattat gatgcgccga gaaaaaagag ataggaggca
tttcaagaga atgcgttttc 540ccccttttga tgatgaggag ccgcccttgg
actatgctga caacatccta aatgttgagc 600cactggaggc cattcagcta
gagctggacc ctgaggagga cgcccctgtg ttggactggt 660tctatgacca
ccagccgttg agggacagca ggaagtatgt aaatggctcc acttaccagc
720gctggcagtt cacactacct atgatgtcaa ctctctaccg cctggctaat
cagctcctga 780cagacttggt ggatgacaac tacttctacc tgtttgattt
gaaggccttc tttacgtcca 840aggcactcaa tatggccatt cctggaggcc
ccaaatttga acctcttgtt cgagacatca 900acctacagga tgaagactgg
aatgaattca atgatattaa caagattatc atccggcagc 960ctatccggac
tgagtacaag attgcttttc cttacttgta caacaatctt ccacaccatg
1020tccacctcac ctggtaccat actcccaatg ttgtattcat caaaactgaa
gatcctgact 1080tgccagcttt ctactttgac cctttgatca acccaatctc
ccataggcac tcagtcaaga 1140gccaggaacc attgccggat gatgatgagg
aatttgagct cccggagttt gtggagccct 1200tcctgaagga cacacccctc
tatacagaca atacagccaa tggcattgcc ctgctctggg 1260ccccgcggcc
cttcaaccta cgctctggtc gcacccgtcg ggccctggac ataccccttg
1320tcaagaactg gtatcgggag cattgtcctg ccgggcagcc
tgtgaaagtg agggtctcct 1380accagaagct gcttaagtac tatgtgctga
atgccctgaa gcatcggccc cctaaggctc 1440aaaagaagag gtatttgttc
cgctccttca aagccaccaa attctttcag tccacaaagc 1500tggactgggt
ggagggttgg ctccaggttt gccgccaggg ctacaacatg ctcaaccttc
1560tcattcaccg caaaaacctc aactacctgc acctggacta caacttcaac
ctcaagcctg 1620tgaaaacgct caccaccaag gaaagaaaga aatctcgttt
tgggaatgct ttccacctgt 1680gtcgggaagt tctgcgtttg actaagctgg
tggtggatag tcacgtgcag tatcggctgg 1740gcaatgtgga tgccttccag
ctggcagatg gattgcagta tatatttgcc catgttgggc 1800agttgacggg
catgtatcga tacaaataca agctgatgcg acagattcgc gtgtgcaagg
1860acctgaagca tctcatctat tatcgtttca acacaggccc tgtagggaag
ggtcctggct 1920gtggcttctg ggctgccggt tggcgagtct ggctcttttt
catgcgtggc attacccctt 1980tattagagcg atggcttggc aacctcctgg
cccggcagtt tgaaggtcga cactcaaagg 2040gggtggcaaa gacagtaaca
aagcagcgag tggagtcaca ttttgacctt gagctgcggg 2100cagctgtgat
gcatgatatt ctggacatga tgcctgaggg gatcaagcag aacaaggccc
2160ggacaatcct gcagcacctc agtgaagcct ggcgctgctg gaaagccaac
attccctgga 2220aggtccctgg gctgccgacg cccatagaga atatgatcct
tcgatacgtg aaggccaagg 2280ctgactggtg gaccaacact gcccactaca
accgagaacg gatccgccga ggggccactg 2340tggacaagac tgtttgtaaa
aagaatctgg gccgcctcac ccggctctat ctgaaggcag 2400aacaggagcg
gcagcacaac tacctgaagg acgggcctta catcacagcg gaggaaacag
2460tggcagtata taccaccaca gtgcattggt tggaaagccg caggttttca
cccatcccat 2520tccccccact ctcctataag catgacacca agttgctcat
cttggcattg gagcggctca 2580aggaagctta tagtgtgaag tctcggttga
accagtctca gagggaggag ctaggtctga 2640tcgagcaggc ctacgataac
ctccacgagg cgctgtcccg cataaagcgt cacctcctca 2700cacagagagc
cttcaaagag gtgggcattg agttcatgga tctgtatagc cacctcgttc
2760cagtatatga tgttgagccc ctggagaaga taactgatgc ttacctggac
cagtacctgt 2820ggtatgaagc cgacaagcgc cgcctgttcc caccctggat
taagcctgca gacacagaac 2880cacctccact gcttgtttac aagtggtgtc
aaggcatcaa taacctgcag gacgtgtggg 2940agacgagtga aggcgagtgc
aatgtcatgc tggaatcccg ctttgagaag atgtatgaga 3000agatcgactt
gactctgctc aacaggctcg tgcgcctcat cgtggaccac aacatagccg
3060actacatgac agccaagaac aacgtcgtca tcaactataa ggacatgaac
catacgaatt 3120catatgggat catcagaggc ctgcagtttg cctcattcat
agtgcagtat tatggcctgg 3180tgatggattt gcttgtattg ggattgcacc
gggccagtga gatggctggg ccccctcaga 3240tgccaaatga ctttctcagt
ttccaggaca tagccactga ggctgcccac cccatccgtc 3300tcttctgcag
atacattgat cgcatccata tttttttcag gttcacagca gatgaggctc
3360gggacctgat tcaacgttac ctgacagagc accctgaccc caataatgaa
aacatcgttg 3420gctataataa caagaagtgc tggccccgag atgcccgcat
gcgcctcatg aaacatgatg 3480ttaacttagg ccgggcggta ttctgggaca
tcaagaaccg cttgccacgg tcagtgacta 3540cagttcagtg ggagaacagc
ttcgtgtctg tgtacagtaa ggacaacccc aacctgctgt 3600tcaacatgtg
tggcttcgag tgccgcatcc tgcctaagtg ccgcaccagc tatgaggagt
3660tcacccacaa ggacggggtc tggaacctgc agaatgaggt tactaaggag
cgcacagctc 3720agtgtttcct gcgtgtggac gatgagtcaa tgcagcgctt
ccacaaccgc gtgcgtcaga 3780ttctcatggc ctctgggtcc accaccttca
ccaagattgt gaataagtgg aatacagctc 3840tcattggcct tatgacatac
tttcgggagg ctgtggtgaa cacccaagag ctcttggact 3900tactggtgaa
gtgtgagcac aaaatccaga cacgtatcaa gattggactc aactccaaga
3960tgccaagtcg gttccccccg gttgtgttct acacccctaa ggagttgggt
ggactcggca 4020tgctctcaat gggccatgtg ctcatccccc aatccgacct
caggtggtcc aaacagacag 4080atgtaggtat cacacacttt cgttcaggaa
tgagccatga agaagaccag ctcattccca 4140acttgtaccg ctacatacag
ccatgggaga gcgagttcat tgattctcag cgggtctggg 4200ctgagtactc
actcaagaga caagaggcca ttgctcagaa cagacgcctg actttagaag
4260acctagaaga ttcatgggat cgtggcattc ctcgaatcaa taccctcttc
cagaaggacc 4320ggcacacact ggcttatgat aagggctggc gtgtcagaac
tgactttaag cagtatcagg 4380ttttgaagca gaatccgttc tggtggacac
accagcggca tgatgggaag ctctggaacc 4440tgaacaacta ccgtacagac
atgatccagg ccctgggcgg tgtggaaggc attctggaac 4500acacactctt
taagggcact tacttcccta cctgggaggg gcttttctgg gagaaggcca
4560gtggctttga ggaatctatg aagtggaaga agctaactaa tgctcagcga
tcaggactga 4620accagattcc caatcgtaga ttcaccctct ggtggtcccc
gaccattaat cgagccaatg 4680tatatgtagg ctttcaggtg cagctagacc
tgacgggtat cttcatgcac ggcaagatcc 4740ccacgctgaa gatctctctc
atccagatct tccgagctca cttgtggcag aagatccatg 4800agagcattgt
tatggactta tgtcaggtgt ttgaccagga acttgatgca ctggaaattg
4860agacagtaca aaaggagaca atccatcccc gaaagtcata taagatgaac
tcttcctgtg 4920cagatatcct gctctttgcc tcctataagt ggaatgtctc
ccggccctca ttgctggctg 4980actccaagga tgtgatggac agcaccacca
cccagaaata ctggattgac atccagttgc 5040gctgggggga ctatgattcc
cacgacattg agcgctacgc ccgggccaag ttcctggact 5100acaccaccga
caacatgagt atctaccctt cgcccacagg tgtactcatc gccattgacc
5160tggcctataa cttgcacagt gcctatggaa actggttccc aggcagcaag
cctctcatac 5220aacaggccat ggccaagatc atgaaggcaa accctgccct
gtatgtgtta cgtgaacgga 5280tccgcaaggg gctacagctc tattcatctg
aacccactga gccttatttg tcttctcaga 5340actatggtga gctcttctcc
aaccagatta tctggtttgt ggatgacacc aacgtctaca 5400gagtgactat
tcacaagacc tttgaaggga acttgacaac caagcccatc aacggagcca
5460tcttcatctt caacccacgc acagggcagc tgttcctcaa gataatccac
acgtccgtgt 5520gggcgggaca gaagcgtttg gggcagttgg ctaagtggaa
gacagctgag gaggtggccg 5580ccctgatccg atctctgcct gtggaggagc
agcccaagca gatcattgtc accaggaagg 5640acatgctgga cccactggag
gtgcacttac tggacttccc caatattgtc atcaaaggat 5700cggagctcca
actccctttc caggcgtgtc tcaaggtgga aaaattcggg gatctcatcc
5760ttaaagccac tgagccccag atggttctct tcaacctcta tgacgactgg
ctcaagacta 5820tttcatctta cacggccttc tcccgtctca tcctgattct
gcgtgcccta catgtgaaca 5880acgatcgggc aaaagtgatc ctgaagccag
acaagactac tattacagaa ccacaccaca 5940tctggcccac tctgactgac
gaagaatgga tcaaggtcga ggtgcagctc aaggatctga 6000tcttggctga
ctacggcaag aaaaacaatg tgaacgtggc atcactgaca caatcagaaa
6060ttcgagacat catcctgggt atggagatct cggcaccgtc acagcagcgg
cagcagatcg 6120ctgagatcga gaagcagacc aaggaacaat cgcagctgac
ggcaacacag actcgcactg 6180tcaacaagca tggcgatgag atcatcacct
ccaccaccag caactatgag acccagactt 6240tctcatccaa gactgagtgg
agggtcaggg ccatctctgc tgccaacctg cacctaagga 6300ccaatcacat
ctatgtttca tctgacgaca tcaaggagac tggctacacc tacatccttc
6360ccaagaatgt gcttaagaag ttcatctgca tatctgacct tcgggcccaa
attgcaggat 6420acctatatgg ggtgagccca ccagataacc cccaggtgaa
ggagatccgc tgcattgtga 6480tggtgccgca gtggggcact caccagaccg
tgcacctgcc tggccagctg ccccagcatg 6540agtacctcaa ggagatggaa
cccttaggtt ggatccacac tcagcccaat gagtccccgc 6600agttatcacc
ccaggatgtc accacccatg ccaagatcat ggctgacaac ccatcttggg
6660atggcgagaa gaccattatc atcacatgca gcttcacgcc aggctcctgt
acactgacgg 6720cctacaagct gacccctagt ggctacgaat ggggccgcca
gaacacagac aagggcaaca 6780accccaaggg ctacctgcct tcacactatg
agagggtgca gatgctgctg tcggaccgtt 6840tccttggctt cttcatggtc
cctgcccagt cctcgtggaa ctacaacttc atgggtgttc 6900ggcatgaccc
caacatgaaa tatgagctac agctggcgaa ccccaaagag ttctaccacg
6960aggtgcacag gccctctcac ttcctcaact ttgctctcct gcaggagggg
gaggtttact 7020ctgcggatcg ggaggacctg tatgcctgac cgtttccctg
cctcctgctt cagcctcccg 7080aggccgaagc ctcagcccct ccagacaggc
cgctgacatt cagcagtttg gcctctttcc 7140ctctgtctgt gcttgtgttg
ttgacctcct gatggcttgt catcctgaat aaaatataat 7200aataaatttt
gtataaatag g 7221392335PRTHomo sapiens 39Met Ala Gly Val Phe Pro
Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 1 5 10 15 Pro Leu Ala Pro
Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 20 25 30 Lys Ala
Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 35 40 45
Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 50
55 60 His Val Arg Glu Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg
Lys 65 70 75 80 Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys
Tyr Met Pro 85 90 95 His Ala Val Leu Lys Leu Leu Glu Asn Met Pro
Met Pro Trp Glu Gln 100 105 110 Ile Arg Asp Val Pro Val Leu Tyr His
Ile Thr Gly Ala Ile Ser Phe 115 120 125 Val Asn Glu Ile Pro Trp Val
Ile Glu Pro Val Tyr Ile Ser Gln Trp 130 135 140 Gly Ser Met Trp Ile
Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 145 150 155 160 Phe Lys
Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 165 170 175
Asp Tyr Ala Asp Asn Ile Leu Asn Val Glu Pro Leu Glu Ala Ile Gln 180
185 190 Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe
Tyr 195 200 205 Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn
Gly Ser Thr 210 215 220 Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met
Ser Thr Leu Tyr Arg 225 230 235 240 Leu Ala Asn Gln Leu Leu Thr Asp
Leu Val Asp Asp Asn Tyr Phe Tyr 245 250 255 Leu Phe Asp Leu Lys Ala
Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 260 265 270 Ile Pro Gly Gly
Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 275 280 285 Gln Asp
Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 290 295 300
Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 305
310 315 320 Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr
Pro Asn 325 330 335 Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro
Ala Phe Tyr Phe 340 345 350 Asp Pro Leu Ile Asn Pro Ile Ser His Arg
His Ser Val Lys Ser Gln 355 360 365 Glu Pro Leu Pro Asp Asp Asp Glu
Glu Phe Glu Leu Pro Glu Phe Val 370 375 380 Glu Pro Phe Leu Lys Asp
Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 385 390 395 400 Gly Ile Ala
Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 405 410 415 Arg
Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 420 425
430 Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln
435 440 445 Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg
Pro Pro 450 455 460 Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe
Lys Ala Thr Lys 465 470 475 480 Phe Phe Gln Ser Thr Lys Leu Asp Trp
Val Glu Gly Trp Leu Gln Val 485 490 495 Cys Arg Gln Gly Tyr Asn Met
Leu Asn Leu Leu Ile His Arg Lys Asn 500 505 510 Leu Asn Tyr Leu His
Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 515 520 525 Thr Leu Thr
Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 530 535 540 His
Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 545 550
555 560 His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala
Asp 565 570 575 Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr
Gly Met Tyr 580 585 590 Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg
Val Cys Lys Asp Leu 595 600 605 Lys His Leu Ile Tyr Tyr Arg Phe Asn
Thr Gly Pro Val Gly Lys Gly 610 615 620 Pro Gly Cys Gly Phe Trp Ala
Ala Gly Trp Arg Val Trp Leu Phe Phe 625 630 635 640 Met Arg Gly Ile
Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 645 650 655 Ala Arg
Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 660 665 670
Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 675
680 685 Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln
Asn 690 695 700 Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp
Arg Cys Trp 705 710 715 720 Lys Ala Asn Ile Pro Trp Lys Val Pro Gly
Leu Pro Thr Pro Ile Glu 725 730 735 Asn Met Ile Leu Arg Tyr Val Lys
Ala Lys Ala Asp Trp Trp Thr Asn 740 745 750 Thr Ala His Tyr Asn Arg
Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 755 760 765 Lys Thr Val Cys
Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 770 775 780 Lys Ala
Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 785 790 795
800 Ile Thr Ala Glu Glu Thr Val Ala Val Tyr Thr Thr Thr Val His Trp
805 810 815 Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu
Ser Tyr 820 825 830 Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu
Arg Leu Lys Glu 835 840 845 Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln
Ser Gln Arg Glu Glu Leu 850 855 860 Gly Leu Ile Glu Gln Ala Tyr Asp
Asn Leu His Glu Ala Leu Ser Arg 865 870 875 880 Ile Lys Arg His Leu
Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 885 890 895 Glu Phe Met
Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 900 905 910 Pro
Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 915 920
925 Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp
930 935 940 Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly
Ile Asn 945 950 955 960 Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly
Glu Cys Asn Val Met 965 970 975 Leu Glu Ser Arg Phe Glu Lys Met Tyr
Glu Lys Ile Asp Leu Thr Leu 980 985 990 Leu Asn Arg Leu Val Arg Leu
Ile Val Asp His Asn Ile Ala Asp Tyr 995 1000 1005 Met Thr Ala Lys
Asn Asn Val Val Ile Asn Tyr Lys Asp Met Asn 1010 1015 1020 His Thr
Asn Ser Tyr Gly Ile Ile Arg Gly Leu Gln Phe Ala Ser 1025 1030 1035
Phe Ile Val Gln Tyr Tyr Gly Leu Val Met Asp Leu Leu Val Leu 1040
1045 1050 Gly Leu His Arg Ala Ser Glu Met Ala Gly Pro Pro Gln Met
Pro 1055 1060 1065 Asn Asp Phe Leu Ser Phe Gln Asp Ile Ala Thr Glu
Ala Ala His 1070 1075 1080 Pro Ile Arg Leu Phe Cys Arg Tyr Ile Asp
Arg Ile His Ile Phe 1085 1090 1095 Phe Arg Phe Thr Ala Asp Glu Ala
Arg Asp Leu Ile Gln Arg Tyr 1100 1105 1110 Leu Thr Glu His Pro Asp
Pro Asn Asn Glu Asn Ile Val Gly Tyr 1115 1120 1125 Asn Asn Lys Lys
Cys Trp Pro Arg Asp Ala Arg Met Arg Leu Met 1130 1135 1140 Lys His
Asp Val Asn Leu Gly Arg Ala Val Phe Trp Asp Ile Lys 1145 1150 1155
Asn Arg Leu Pro Arg Ser Val Thr Thr Val Gln Trp Glu Asn Ser 1160
1165 1170 Phe Val Ser Val Tyr Ser Lys Asp Asn Pro Asn Leu Leu Phe
Asn 1175 1180 1185 Met Cys Gly Phe Glu Cys Arg Ile Leu Pro Lys Cys
Arg Thr Ser 1190 1195 1200 Tyr Glu Glu Phe Thr His Lys Asp Gly Val
Trp Asn Leu Gln Asn 1205 1210 1215 Glu Val Thr Lys Glu Arg Thr Ala
Gln Cys Phe Leu Arg Val Asp 1220 1225 1230 Asp Glu Ser Met Gln Arg
Phe His Asn Arg Val Arg Gln Ile Leu 1235 1240 1245 Met Ala Ser Gly
Ser Thr Thr Phe Thr Lys Ile Val Asn Lys Trp 1250 1255 1260 Asn Thr
Ala Leu Ile Gly Leu Met Thr Tyr Phe Arg Glu Ala Val 1265 1270 1275
Val Asn Thr Gln Glu Leu Leu Asp Leu Leu Val Lys Cys Glu His 1280
1285 1290 Lys Ile Gln Thr Arg Ile Lys Ile Gly Leu Asn Ser Lys Met
Pro 1295 1300 1305 Ser Arg Phe Pro Pro Val Val Phe Tyr Thr Pro Lys
Glu Leu Gly 1310 1315 1320 Gly Leu Gly Met Leu Ser Met Gly His Val
Leu Ile Pro Gln Ser 1325 1330 1335 Asp Leu Arg Trp Ser Lys Gln Thr
Asp Val Gly Ile Thr His Phe 1340 1345 1350 Arg Ser Gly Met Ser His
Glu Glu Asp Gln Leu Ile Pro Asn Leu 1355 1360 1365 Tyr Arg Tyr Ile
Gln Pro Trp Glu Ser Glu Phe Ile Asp Ser Gln 1370 1375
1380 Arg Val Trp Ala Glu Tyr Ser Leu Lys Arg Gln Glu Ala Ile Ala
1385 1390 1395 Gln Asn Arg Arg Leu Thr Leu Glu Asp Leu Glu Asp Ser
Trp Asp 1400 1405 1410 Arg Gly Ile Pro Arg Ile Asn Thr Leu Phe Gln
Lys Asp Arg His 1415 1420 1425 Thr Leu Ala Tyr Asp Lys Gly Trp Arg
Val Arg Thr Asp Phe Lys 1430 1435 1440 Gln Tyr Gln Val Leu Lys Gln
Asn Pro Phe Trp Trp Thr His Gln 1445 1450 1455 Arg His Asp Gly Lys
Leu Trp Asn Leu Asn Asn Tyr Arg Thr Asp 1460 1465 1470 Met Ile Gln
Ala Leu Gly Gly Val Glu Gly Ile Leu Glu His Thr 1475 1480 1485 Leu
Phe Lys Gly Thr Tyr Phe Pro Thr Trp Glu Gly Leu Phe Trp 1490 1495
1500 Glu Lys Ala Ser Gly Phe Glu Glu Ser Met Lys Trp Lys Lys Leu
1505 1510 1515 Thr Asn Ala Gln Arg Ser Gly Leu Asn Gln Ile Pro Asn
Arg Arg 1520 1525 1530 Phe Thr Leu Trp Trp Ser Pro Thr Ile Asn Arg
Ala Asn Val Tyr 1535 1540 1545 Val Gly Phe Gln Val Gln Leu Asp Leu
Thr Gly Ile Phe Met His 1550 1555 1560 Gly Lys Ile Pro Thr Leu Lys
Ile Ser Leu Ile Gln Ile Phe Arg 1565 1570 1575 Ala His Leu Trp Gln
Lys Ile His Glu Ser Ile Val Met Asp Leu 1580 1585 1590 Cys Gln Val
Phe Asp Gln Glu Leu Asp Ala Leu Glu Ile Glu Thr 1595 1600 1605 Val
Gln Lys Glu Thr Ile His Pro Arg Lys Ser Tyr Lys Met Asn 1610 1615
1620 Ser Ser Cys Ala Asp Ile Leu Leu Phe Ala Ser Tyr Lys Trp Asn
1625 1630 1635 Val Ser Arg Pro Ser Leu Leu Ala Asp Ser Lys Asp Val
Met Asp 1640 1645 1650 Ser Thr Thr Thr Gln Lys Tyr Trp Ile Asp Ile
Gln Leu Arg Trp 1655 1660 1665 Gly Asp Tyr Asp Ser His Asp Ile Glu
Arg Tyr Ala Arg Ala Lys 1670 1675 1680 Phe Leu Asp Tyr Thr Thr Asp
Asn Met Ser Ile Tyr Pro Ser Pro 1685 1690 1695 Thr Gly Val Leu Ile
Ala Ile Asp Leu Ala Tyr Asn Leu His Ser 1700 1705 1710 Ala Tyr Gly
Asn Trp Phe Pro Gly Ser Lys Pro Leu Ile Gln Gln 1715 1720 1725 Ala
Met Ala Lys Ile Met Lys Ala Asn Pro Ala Leu Tyr Val Leu 1730 1735
1740 Arg Glu Arg Ile Arg Lys Gly Leu Gln Leu Tyr Ser Ser Glu Pro
1745 1750 1755 Thr Glu Pro Tyr Leu Ser Ser Gln Asn Tyr Gly Glu Leu
Phe Ser 1760 1765 1770 Asn Gln Ile Ile Trp Phe Val Asp Asp Thr Asn
Val Tyr Arg Val 1775 1780 1785 Thr Ile His Lys Thr Phe Glu Gly Asn
Leu Thr Thr Lys Pro Ile 1790 1795 1800 Asn Gly Ala Ile Phe Ile Phe
Asn Pro Arg Thr Gly Gln Leu Phe 1805 1810 1815 Leu Lys Ile Ile His
Thr Ser Val Trp Ala Gly Gln Lys Arg Leu 1820 1825 1830 Gly Gln Leu
Ala Lys Trp Lys Thr Ala Glu Glu Val Ala Ala Leu 1835 1840 1845 Ile
Arg Ser Leu Pro Val Glu Glu Gln Pro Lys Gln Ile Ile Val 1850 1855
1860 Thr Arg Lys Asp Met Leu Asp Pro Leu Glu Val His Leu Leu Asp
1865 1870 1875 Phe Pro Asn Ile Val Ile Lys Gly Ser Glu Leu Gln Leu
Pro Phe 1880 1885 1890 Gln Ala Cys Leu Lys Val Glu Lys Phe Gly Asp
Leu Ile Leu Lys 1895 1900 1905 Ala Thr Glu Pro Gln Met Val Leu Phe
Asn Leu Tyr Asp Asp Trp 1910 1915 1920 Leu Lys Thr Ile Ser Ser Tyr
Thr Ala Phe Ser Arg Leu Ile Leu 1925 1930 1935 Ile Leu Arg Ala Leu
His Val Asn Asn Asp Arg Ala Lys Val Ile 1940 1945 1950 Leu Lys Pro
Asp Lys Thr Thr Ile Thr Glu Pro His His Ile Trp 1955 1960 1965 Pro
Thr Leu Thr Asp Glu Glu Trp Ile Lys Val Glu Val Gln Leu 1970 1975
1980 Lys Asp Leu Ile Leu Ala Asp Tyr Gly Lys Lys Asn Asn Val Asn
1985 1990 1995 Val Ala Ser Leu Thr Gln Ser Glu Ile Arg Asp Ile Ile
Leu Gly 2000 2005 2010 Met Glu Ile Ser Ala Pro Ser Gln Gln Arg Gln
Gln Ile Ala Glu 2015 2020 2025 Ile Glu Lys Gln Thr Lys Glu Gln Ser
Gln Leu Thr Ala Thr Gln 2030 2035 2040 Thr Arg Thr Val Asn Lys His
Gly Asp Glu Ile Ile Thr Ser Thr 2045 2050 2055 Thr Ser Asn Tyr Glu
Thr Gln Thr Phe Ser Ser Lys Thr Glu Trp 2060 2065 2070 Arg Val Arg
Ala Ile Ser Ala Ala Asn Leu His Leu Arg Thr Asn 2075 2080 2085 His
Ile Tyr Val Ser Ser Asp Asp Ile Lys Glu Thr Gly Tyr Thr 2090 2095
2100 Tyr Ile Leu Pro Lys Asn Val Leu Lys Lys Phe Ile Cys Ile Ser
2105 2110 2115 Asp Leu Arg Ala Gln Ile Ala Gly Tyr Leu Tyr Gly Val
Ser Pro 2120 2125 2130 Pro Asp Asn Pro Gln Val Lys Glu Ile Arg Cys
Ile Val Met Val 2135 2140 2145 Pro Gln Trp Gly Thr His Gln Thr Val
His Leu Pro Gly Gln Leu 2150 2155 2160 Pro Gln His Glu Tyr Leu Lys
Glu Met Glu Pro Leu Gly Trp Ile 2165 2170 2175 His Thr Gln Pro Asn
Glu Ser Pro Gln Leu Ser Pro Gln Asp Val 2180 2185 2190 Thr Thr His
Ala Lys Ile Met Ala Asp Asn Pro Ser Trp Asp Gly 2195 2200 2205 Glu
Lys Thr Ile Ile Ile Thr Cys Ser Phe Thr Pro Gly Ser Cys 2210 2215
2220 Thr Leu Thr Ala Tyr Lys Leu Thr Pro Ser Gly Tyr Glu Trp Gly
2225 2230 2235 Arg Gln Asn Thr Asp Lys Gly Asn Asn Pro Lys Gly Tyr
Leu Pro 2240 2245 2250 Ser His Tyr Glu Arg Val Gln Met Leu Leu Ser
Asp Arg Phe Leu 2255 2260 2265 Gly Phe Phe Met Val Pro Ala Gln Ser
Ser Trp Asn Tyr Asn Phe 2270 2275 2280 Met Gly Val Arg His Asp Pro
Asn Met Lys Tyr Glu Leu Gln Leu 2285 2290 2295 Ala Asn Pro Lys Glu
Phe Tyr His Glu Val His Arg Pro Ser His 2300 2305 2310 Phe Leu Asn
Phe Ala Leu Leu Gln Glu Gly Glu Val Tyr Ser Ala 2315 2320 2325 Asp
Arg Glu Asp Leu Tyr Ala 2330 2335 407972DNAHomo sapiens
40atttgaagtc ctcgttccac gccttctcat catcctgaac accgagctct gggactccgg
60cggagaatct aaacgtaaag catcacccac ggtcgtgaac tgtaggctct cctggcatcc
120gggatcttat tctggccttg gcggagttgg ggatggtgtc gcctagcagc
cgctgccgct 180ttggcttgct cgggaccatt tggctggacc cagagtccgc
gtggaaccgc gatagggatc 240tgtcagggcc cgcggccggg tccagcttgg
tggttgcggt agtgagaggc ctccgctggt 300tgccaggctt ggtctagagg
tggagcacag tgaaagaatt caagatgcca cctaatataa 360actggaaaga
aataatgaaa gttgacccag atgacctgcc ccgtcaagaa gaactggcag
420ataatttatt gatttcctta tccaaggtgg aagtaaatga gctaaaaagt
gaaaagcaag 480aaaatgtgat acaccttttc agaattactc agtcactaat
gaagatgaaa gctcaagaag 540tggagctggc tttggaagaa gtagaaaaag
ctggagaaga acaagcaaaa tttgaaaatc 600aattaaaaac taaagtaatg
aaactggaaa atgaactgga gatggctcag cagtctgcag 660gtggacgaga
tactcggttt ttacgtaatg aaatttgcca acttgaaaaa caattagaac
720aaaaagatag agaattggag gacatggaaa aggagttgga gaaagagaag
aaagttaatg 780agcaattggc tcttcgaaat gaggaggcag aaaatgaaaa
cagcaaatta agaagagaga 840acaaacgtct aaagaaaaag aatgaacaac
tttgtcagga tattattgac taccagaaac 900aaatagattc acagaaagaa
acacttttat caagaagagg ggaagacagt gactaccgat 960cacagttgtc
taaaaaaaac tatgagctta tccaatatct tgatgaaatt cagactttaa
1020cagaagctaa tgagaaaatt gaagttcaga atcaagaaat gagaaaaaat
ttagaagagt 1080ctgtacagga aatggagaag atgactgatg aatataatag
aatgaaagct attgtgcatc 1140agacagataa tgtaatagat cagttaaaaa
aagaaaacga tcattatcaa cttcaagtgc 1200aggagcttac agatcttctg
aaatcaaaaa atgaagaaga tgatccaatt atggtagctg 1260tcaatgcaaa
agtagaagaa tggaagctaa ttttgtcttc taaagatgat gaaattattg
1320agtatcagca aatgttacat aacctaaggg agaaacttaa gaatgctcag
cttgatgctg 1380ataaaagtaa tgttatggct ctacagcagg gtatacagga
acgagacagt caaattaaga 1440tgctcaccga acaagtagaa caatatacaa
aagaaatgga aaagaatact tgtattattg 1500aagatttgaa aaatgagctc
caaagaaaca aaggtgcttc aaccctttct caacagactc 1560atatgaaaat
tcagtcaacg ttagacattt taaaagagaa aactaaagag gctgagagaa
1620cagctgaact ggctgaggct gatgctaggg aaaaggataa agaattagtt
gaggctctga 1680agaggttaaa agattatgaa tcgggagtat atggtttaga
agatgctgtc gttgaaataa 1740agaattgtaa aaaccaaatt aaaataagag
atcgagagat tgaaatatta acaaaggaaa 1800tcaataaact tgaattgaag
atcagtgatt tccttgatga aaatgaggca cttagagagc 1860gtgtgggcct
tgaaccaaag acaatgattg atttaactga atttagaaat agcaaacact
1920taaaacagca gcagtacaga gctgaaaacc agattctttt gaaagagatt
gaaagtctag 1980aggaagaacg acttgatctg aaaaaaaaaa ttcgtcaaat
ggctcaagaa agaggaaaaa 2040gaagtgcaac ttcaggatta accactgagg
acctgaacct aactgaaaac atttctcaag 2100gagatagaat aagtgaaaga
aaattggatt tattgagcct caaaaatatg agtgaagcac 2160aatcaaagaa
tgaatttctt tcaagagaac taattgaaaa agaaagagat ttagaaagga
2220gtaggacagt gatagccaaa tttcagaata aattaaaaga attagttgaa
gaaaataagc 2280aacttgaaga aggtatgaaa gaaatattgc aagcaattaa
ggaaatgcag aaagatcctg 2340atgttaaagg aggagaaaca tctctaatta
tccctagcct tgaaagacta gttaatgcta 2400tagaatcaaa gaatgcagaa
ggaatctttg atgcgagtct gcatttgaaa gcccaagttg 2460atcagcttac
cggaagaaat gaagaattaa gacaggagct cagggaatct cggaaagagg
2520ctataaatta ttcacagcag ttggcaaaag ctaatttaaa gatagaccat
cttgaaaaag 2580aaactagtct tttacgacaa tcagaaggat cgaatgttgt
ttttaaagga attgacttac 2640ctgatgggat agcaccatct agtgccagta
tcattaattc tcagaatgaa tatttaatac 2700atttgttaca ggaactagaa
aataaagaaa aaaagttaaa gaatttagaa gattctcttg 2760aagattacaa
cagaaaattt gctgtaattc gtcatcaaca aagtttgttg tataaagaat
2820acctaagtga aaaggagacc tggaaaacag aatctaaaac aataaaagag
gaaaagagaa 2880aacttgagga tcaagtccaa caagatgcta taaaagtaaa
agaatataat aatttgctca 2940atgctcttca gatggattcg gatgaaatga
aaaaaatact tgcagaaaat agtaggaaaa 3000ttactgtttt gcaagtgaat
gaaaaatcac ttataaggca atatacaacc ttagtagaat 3060tggagcgaca
acttagaaaa gaaaatgaga agcaaaagaa tgaattgttg tcaatggagg
3120ctgaagtttg tgaaaaaatt gggtgtttgc aaagatttaa ggaaatggcc
attttcaaga 3180ttgcagctct ccaaaaagtt gtagataata gtgtttcttt
gtctgaacta gaactggcta 3240ataaacagta caatgaactg actgctaagt
acagggacat cttgcaaaaa gataatatgc 3300ttgttcaaag aacaagtaac
ttggaacacc tggagtgtga aaacatctcc ttaaaagaac 3360aagtggagtc
tataaataaa gaactggaga ttaccaagga aaaacttcac actattgaac
3420aagcctggga acaggaaact aaattaggta atgaatctag catggataag
gcaaagaaat 3480caataaccaa cagtgacatt gtttccattt caaaaaaaat
aactatgctg gaaatgaagg 3540aattaaatga aaggcagcgg gctgaacatt
gtcaaaaaat gtatgaacac ttacggactt 3600cgttaaagca aatggaggaa
cgtaattttg aattggaaac caaatttgct gagcttacca 3660aaatcaattt
ggatgcacag aaggtggaac agatgttaag agatgaatta gctgatagtg
3720tgagcaaggc agtaagtgat gctgataggc aacggattct agaattagag
aagaatgaaa 3780tggaactaaa agttgaagtg tcaaaactga gagagatttc
tgatattgcc agaagacaag 3840ttgaaatttt gaatgcacaa caacaatcta
gggacaagga agtagagtcc ctcagaatgc 3900aactgctaga ctatcaggca
cagtctgatg aaaagtcgct cattgccaag ttgcaccaac 3960ataatgtctc
tcttcaactg agtgaggcta ctgctcttgg taagttggag tcaattacat
4020ctaaactgca gaagatggag gcctacaact tgcgcttaga gcagaaactt
gatgaaaaag 4080aacaggctct ctattatgct cgtttggagg gaagaaacag
agcaaaacat ctgcgccaaa 4140caattcagtc tctacgacga cagtttagtg
gagctttacc cttggcacaa caggaaaagt 4200tctccaaaac aatgattcaa
ctacaaaatg acaaacttaa gataatgcaa gaaatgaaaa 4260attctcaaca
agaacataga aatatggaga acaaaacatt ggagatggaa ttaaaattaa
4320agggcctgga agagttaata agcactttaa aggataccaa aggagcccaa
aaggtaatca 4380actggcatat gaaaatagaa gaacttcgtc ttcaagaact
taaactaaat cgggaattag 4440tcaaggataa agaagaaata aaatatttga
ataacataat ttctgaatat gaacgtacaa 4500tcagcagtct tgaagaagaa
attgtgcaac agaacaagtt tcatgaagaa agacaaatgg 4560cctgggatca
aagagaagtt gacctggaac gccaactaga catttttgac cgtcagcaaa
4620atgaaatact aaatgcggca caaaagtttg aagaagctac aggatcaatc
cctgacccta 4680gtttgcccct tccaaatcaa cttgagatcg ctctaaggaa
aattaaggag aacattcgaa 4740taattctaga aacacgggca acttgcaaat
cactagaaga gaaactaaaa gagaaagaat 4800ctgctttaag gttagcagaa
caaaatatac tgtcaagaga caaagtaatc aatgaactga 4860ggcttcgatt
gcctgccact gcagaaagag aaaagctcat agctgagcta ggcagaaaag
4920agatggaacc aaaatctcac cacacattga aaattgctca tcaaaccatt
gcaaacatgc 4980aagcaaggtt aaatcaaaaa gaagaagtat taaagaagta
tcaacgtctt ctagaaaaag 5040ccagagagga gcaaagagaa attgtgaaga
aacatgagga agaccttcat attcttcatc 5100acagattaga actacaggct
gatagttcac taaataaatt caaacaaacg gcttgggatt 5160taatgaaaca
gtctcccact ccagttccta ccaacaagca ttttattcgt ctggctgaga
5220tggaacagac agtagcagaa caagatgact ctctttcctc actcttggtc
aaactaaaga 5280aagtatcaca agatttggag agacaaagag aaatcactga
attaaaagta aaagaatttg 5340aaaatatcaa attacagctt caagaaaacc
atgaagatga agtgaaaaaa gtaaaagcgg 5400aagtagagga tttaaagtat
cttctggacc agtcacaaaa ggagtcacag tgtttaaaat 5460ctgaacttca
ggctcaaaaa gaagcaaatt caagagctcc aacaactaca atgagaaatc
5520tagtagaacg gctaaagagc caattagcct tgaaggagaa acaacagaaa
gcacttagtc 5580gggcactttt agaactccgg gcagaaatga cagcagctgc
tgaagaacgt attatttctg 5640caacttctca aaaagaggcc catctcaatg
ttcaacaaat cgttgatcga catactagag 5700agctaaagac acaagttgaa
gatttaaatg aaaatctttt aaaattgaaa gaagcactta 5760aaacaagtaa
aaacagagaa aactcactaa ctgataattt gaatgactta aataatgaac
5820tgcaaaagaa acaaaaagcc tataataaaa tacttagaga gaaagaggaa
attgatcaag 5880agaatgatga actgaaaagg caaattaaaa gactaaccag
tggattacag ggcaaacccc 5940tgacagataa taaacaaagt ctaattgaag
aactccaaag gaaagttaaa aaactagaga 6000accaattaga gggaaaggtg
gaggaagtag acctaaaacc tatgaaagaa aagaatgcta 6060aagaagaatt
aattaggtgg gaagaaggta aaaagtggca agccaaaata gaaggaattc
6120gaaacaagtt aaaagagaaa gagggggaag tctttacttt aacaaagcag
ttgaatactt 6180tgaaggatct ttttgccaaa gccgataaag agaaacttac
tttgcagagg aaactaaaaa 6240caactggcat gactgttgat caggttttgg
gaatacgagc tttggagtca gaaaaagaat 6300tggaagaatt aaaaaagaga
aatcttgact tagaaaatga tatattgtat atgagggccc 6360accaagctct
tcctcgagat tctgttgtag aagatttaca tttacaaaat agatacctcc
6420aagaaaaact tcatgcttta gaaaaacagt tttcaaagga tacatattct
aagccttcaa 6480tttcaggaat agagtcagat gatcattgtc agagagaaca
ggagcttcag aaggaaaact 6540tgaagttgtc atctgaaaat attgaactga
aatttcagct tgaacaagca aataaagatt 6600tgccaagatt aaagaatcaa
gtcagagatt tgaaggaaat gtgtgaattt cttaagaaag 6660aaaaagcaga
agttcagcgg aaacttggcc atgttagagg gtctggtaga agtggaaaga
6720caatcccaga actggaaaaa accattggtt taatgaaaaa agtagttgaa
aaagtccaga 6780gagaaaatga acagttgaaa aaagcatcag gaatattgac
tagtgaaaaa atggctaata 6840ttgagcagga aaatgaaaaa ttgaaggctg
aattagaaaa acttaaagct catcttgggc 6900atcagttgag catgcactat
gaatccaaga ccaaaggcac agaaaaaatt attgctgaaa 6960atgaaaggct
tcgtaaagaa cttaaaaaag aaactgatgc tgcagagaaa ttacggatag
7020caaagaataa tttagagata ttaaatgaga agatgacagt tcaactagaa
gagactggta 7080agagattgca gtttgcagaa agcagaggtc cacagcttga
aggtgctgac agtaagagct 7140ggaaatccat tgtggttaca agaatgtatg
aaaccaagtt aaaagaattg gaaactgata 7200ttgccaaaaa aaatcaaagc
attactgacc ttaaacagct tgtaaaagaa gcaacagaga 7260gagaacaaaa
agttaacaaa tacaatgaag accttgaaca acagattaag attcttaaac
7320atgttcctga aggtgctgag acagagcaag gccttaaacg ggagcttcaa
gttcttagat 7380tagctaatca tcagctggat aaagagaaag cagaattaat
ccatcagata gaagctaaca 7440aggaccaaag tggagctgaa agcaccatac
ctgatgctga tcaactaaag gaaaaaataa 7500aagatctaga gacacagctc
aaaatgtcag atctagaaaa gcagcatttg aaggaggaaa 7560taaagaagct
gaaaaaagaa ctggaaaatt ttgatccttc attttttgaa gaaattgaag
7620atcttaagta taattacaag gaagaagtga agaagaatat tctcttagaa
gagaaggtaa 7680aaaaactttc agaacaattg ggagttgaat taactagccc
tgttgctgct tctgaagagt 7740ttgaagatga agaagaaagt cctgttaatt
tccccattta ctaaaggtca cctataaact 7800ttgtttcatt taactattta
ttaactttat aagttaaata tacttggaaa taagcagttc 7860tccgaactgt
agtatttcct tctcactacc ttgtaccttt atacttagat tggaattctt
7920aataaataaa attatatgaa attttcaact tattaaaaaa aaaaaaaaaa aa
7972412479PRTHomo sapiens 41Met Pro Pro Asn Ile Asn Trp Lys Glu Ile
Met Lys Val Asp Pro Asp 1 5 10 15 Asp Leu Pro Arg Gln Glu Glu Leu
Ala Asp Asn Leu Leu Ile Ser Leu 20 25 30 Ser Lys Val Glu Val Asn
Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 35 40 45 Ile His Leu Phe
Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 50 55 60 Glu Val
Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 65
70 75 80 Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu
Glu Asn 85 90 95 Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg
Asp Thr Arg Phe 100 105 110 Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys
Gln Leu Glu Gln Lys Asp 115 120 125 Arg Glu Leu Glu Asp Met Glu Lys
Glu Leu Glu Lys Glu Lys Lys Val 130 135 140 Asn Glu Gln Leu Ala Leu
Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 145 150 155 160 Lys Leu Arg
Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 165 170 175 Cys
Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 180 185
190 Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu
195 200 205 Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile
Gln Thr 210 215 220 Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn
Gln Glu Met Arg 225 230 235 240 Lys Asn Leu Glu Glu Ser Val Gln Glu
Met Glu Lys Met Thr Asp Glu 245 250 255 Tyr Asn Arg Met Lys Ala Ile
Val His Gln Thr Asp Asn Val Ile Asp 260 265 270 Gln Leu Lys Lys Glu
Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 275 280 285 Thr Asp Leu
Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 290 295 300 Ala
Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 305 310
315 320 Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg
Glu 325 330 335 Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn
Val Met Ala 340 345 350 Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln
Ile Lys Met Leu Thr 355 360 365 Glu Gln Val Glu Gln Tyr Thr Lys Glu
Met Glu Lys Asn Thr Cys Ile 370 375 380 Ile Glu Asp Leu Lys Asn Glu
Leu Gln Arg Asn Lys Gly Ala Ser Thr 385 390 395 400 Leu Ser Gln Gln
Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 405 410 415 Lys Glu
Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 420 425 430
Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 435
440 445 Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val
Glu 450 455 460 Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg
Glu Ile Glu 465 470 475 480 Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu
Leu Lys Ile Ser Asp Phe 485 490 495 Leu Asp Glu Asn Glu Ala Leu Arg
Glu Arg Val Gly Leu Glu Pro Lys 500 505 510 Thr Met Ile Asp Leu Thr
Glu Phe Arg Asn Ser Lys His Leu Lys Gln 515 520 525 Gln Gln Tyr Arg
Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 530 535 540 Leu Glu
Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 545 550 555
560 Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp
565 570 575 Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser
Glu Arg 580 585 590 Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu
Ala Gln Ser Lys 595 600 605 Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu
Lys Glu Arg Asp Leu Glu 610 615 620 Arg Ser Arg Thr Val Ile Ala Lys
Phe Gln Asn Lys Leu Lys Glu Leu 625 630 635 640 Val Glu Glu Asn Lys
Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 645 650 655 Ala Ile Lys
Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 660 665 670 Ser
Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 675 680
685 Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln
690 695 700 Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu
Leu Arg 705 710 715 720 Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln
Gln Leu Ala Lys Ala 725 730 735 Asn Leu Lys Ile Asp His Leu Glu Lys
Glu Thr Ser Leu Leu Arg Gln 740 745 750 Ser Glu Gly Ser Asn Val Val
Phe Lys Gly Ile Asp Leu Pro Asp Gly 755 760 765 Ile Ala Pro Ser Ser
Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 770 775 780 Ile His Leu
Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 785 790 795 800
Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 805
810 815 His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu
Thr 820 825 830 Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg
Lys Leu Glu 835 840 845 Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys
Glu Tyr Asn Asn Leu 850 855 860 Leu Asn Ala Leu Gln Met Asp Ser Asp
Glu Met Lys Lys Ile Leu Ala 865 870 875 880 Glu Asn Ser Arg Lys Ile
Thr Val Leu Gln Val Asn Glu Lys Ser Leu 885 890 895 Ile Arg Gln Tyr
Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 900 905 910 Glu Asn
Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 915 920 925
Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 930
935 940 Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu
Ser 945 950 955 960 Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu
Thr Ala Lys Tyr 965 970 975 Arg Asp Ile Leu Gln Lys Asp Asn Met Leu
Val Gln Arg Thr Ser Asn 980 985 990 Leu Glu His Leu Glu Cys Glu Asn
Ile Ser Leu Lys Glu Gln Val Glu 995 1000 1005 Ser Ile Asn Lys Glu
Leu Glu Ile Thr Lys Glu Lys Leu His Thr 1010 1015 1020 Ile Glu Gln
Ala Trp Glu Gln Glu Thr Lys Leu Gly Asn Glu Ser 1025 1030 1035 Ser
Met Asp Lys Ala Lys Lys Ser Ile Thr Asn Ser Asp Ile Val 1040 1045
1050 Ser Ile Ser Lys Lys Ile Thr Met Leu Glu Met Lys Glu Leu Asn
1055 1060 1065 Glu Arg Gln Arg Ala Glu His Cys Gln Lys Met Tyr Glu
His Leu 1070 1075 1080 Arg Thr Ser Leu Lys Gln Met Glu Glu Arg Asn
Phe Glu Leu Glu 1085 1090 1095 Thr Lys Phe Ala Glu Leu Thr Lys Ile
Asn Leu Asp Ala Gln Lys 1100 1105 1110 Val Glu Gln Met Leu Arg Asp
Glu Leu Ala Asp Ser Val Ser Lys 1115 1120 1125 Ala Val Ser Asp Ala
Asp Arg Gln Arg Ile Leu Glu Leu Glu Lys 1130 1135 1140 Asn Glu Met
Glu Leu Lys Val Glu Val Ser Lys Leu Arg Glu Ile 1145 1150 1155 Ser
Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn Ala Gln Gln 1160 1165
1170 Gln Ser Arg Asp Lys Glu Val Glu Ser Leu Arg Met Gln Leu Leu
1175 1180 1185 Asp Tyr Gln Ala Gln Ser Asp Glu Lys Ser Leu Ile Ala
Lys Leu 1190 1195 1200 His Gln His Asn Val Ser Leu Gln Leu Ser Glu
Ala Thr Ala Leu 1205 1210 1215 Gly Lys Leu Glu Ser Ile Thr Ser Lys
Leu Gln Lys Met Glu Ala 1220 1225 1230 Tyr Asn Leu Arg Leu Glu Gln
Lys Leu Asp Glu Lys Glu Gln Ala 1235 1240 1245 Leu Tyr Tyr Ala Arg
Leu Glu Gly Arg Asn Arg Ala Lys His Leu 1250 1255 1260 Arg Gln Thr
Ile Gln Ser Leu Arg Arg Gln Phe Ser Gly Ala Leu 1265 1270 1275 Pro
Leu Ala Gln Gln Glu Lys Phe Ser Lys Thr Met Ile Gln Leu 1280 1285
1290 Gln Asn Asp Lys Leu Lys Ile Met Gln Glu Met Lys Asn Ser Gln
1295 1300 1305 Gln Glu His Arg Asn Met Glu Asn Lys Thr Leu Glu Met
Glu Leu 1310 1315 1320 Lys Leu Lys Gly Leu Glu Glu Leu Ile Ser Thr
Leu Lys Asp Thr 1325 1330 1335 Lys Gly Ala Gln Lys Val Ile Asn Trp
His Met Lys Ile Glu Glu 1340 1345 1350 Leu Arg Leu Gln Glu Leu Lys
Leu Asn Arg Glu Leu Val Lys Asp 1355 1360 1365 Lys Glu Glu Ile Lys
Tyr Leu Asn Asn Ile Ile Ser Glu Tyr Glu 1370 1375 1380 Arg Thr Ile
Ser Ser Leu Glu Glu Glu Ile Val Gln Gln Asn Lys 1385 1390 1395 Phe
His Glu Glu Arg Gln Met Ala Trp Asp Gln Arg Glu Val Asp 1400 1405
1410 Leu Glu Arg Gln Leu Asp Ile Phe Asp Arg Gln Gln Asn Glu Ile
1415 1420 1425 Leu Asn Ala Ala Gln Lys Phe Glu Glu Ala Thr Gly Ser
Ile Pro 1430 1435 1440 Asp Pro Ser Leu Pro Leu Pro Asn Gln Leu Glu
Ile Ala Leu Arg 1445 1450 1455 Lys Ile Lys Glu Asn Ile Arg Ile Ile
Leu Glu Thr Arg Ala Thr 1460 1465 1470 Cys Lys Ser Leu Glu Glu Lys
Leu Lys Glu Lys Glu Ser Ala Leu 1475 1480 1485 Arg Leu Ala Glu Gln
Asn Ile Leu Ser Arg Asp Lys Val Ile Asn 1490 1495 1500 Glu Leu Arg
Leu Arg Leu Pro Ala Thr Ala Glu Arg Glu Lys Leu 1505 1510 1515 Ile
Ala Glu Leu Gly Arg Lys Glu Met Glu Pro Lys Ser His His 1520 1525
1530 Thr Leu Lys Ile Ala His Gln Thr Ile Ala Asn Met Gln Ala Arg
1535 1540 1545 Leu Asn Gln Lys Glu Glu Val Leu Lys Lys Tyr Gln Arg
Leu Leu 1550 1555 1560 Glu Lys Ala Arg Glu Glu Gln Arg Glu Ile Val
Lys Lys His Glu 1565 1570 1575 Glu Asp Leu His Ile Leu His His Arg
Leu Glu Leu Gln Ala Asp 1580 1585 1590 Ser Ser Leu Asn Lys Phe Lys
Gln Thr Ala Trp Asp Leu Met Lys 1595 1600 1605 Gln Ser Pro Thr Pro
Val Pro Thr Asn Lys His Phe Ile Arg Leu 1610 1615 1620 Ala Glu Met
Glu Gln Thr Val Ala Glu Gln Asp Asp Ser Leu Ser 1625 1630 1635 Ser
Leu Leu Val Lys Leu Lys Lys Val Ser Gln Asp Leu Glu Arg 1640 1645
1650 Gln Arg Glu Ile Thr Glu Leu Lys Val Lys Glu Phe Glu Asn Ile
1655 1660 1665 Lys Leu Gln Leu Gln Glu Asn His Glu Asp Glu Val Lys
Lys Val 1670 1675 1680 Lys Ala Glu Val Glu Asp Leu Lys Tyr Leu Leu
Asp Gln Ser Gln 1685 1690 1695 Lys Glu Ser Gln Cys Leu Lys Ser Glu
Leu Gln Ala Gln Lys Glu 1700 1705 1710 Ala Asn Ser Arg Ala Pro Thr
Thr Thr Met Arg Asn Leu Val Glu 1715 1720 1725 Arg Leu Lys Ser Gln
Leu Ala Leu Lys Glu Lys Gln Gln Lys Ala 1730 1735 1740 Leu Ser Arg
Ala Leu Leu Glu Leu Arg Ala Glu Met Thr Ala Ala 1745 1750 1755 Ala
Glu Glu Arg Ile Ile Ser Ala Thr Ser Gln Lys Glu Ala His 1760 1765
1770 Leu Asn Val Gln Gln Ile Val Asp Arg His Thr Arg Glu Leu Lys
1775 1780 1785 Thr Gln Val Glu Asp Leu Asn Glu Asn Leu Leu Lys Leu
Lys Glu 1790 1795 1800 Ala Leu Lys Thr Ser Lys Asn Arg Glu Asn Ser
Leu Thr Asp Asn 1805 1810 1815 Leu Asn Asp Leu Asn Asn Glu Leu Gln
Lys Lys Gln Lys Ala Tyr 1820 1825 1830 Asn Lys Ile Leu Arg Glu Lys
Glu Glu Ile Asp Gln Glu Asn Asp 1835 1840 1845 Glu Leu Lys Arg Gln
Ile Lys Arg Leu Thr Ser Gly Leu Gln Gly 1850 1855 1860 Lys Pro Leu
Thr Asp Asn Lys Gln Ser Leu Ile Glu Glu Leu Gln 1865 1870 1875 Arg
Lys Val Lys Lys Leu Glu Asn Gln Leu Glu Gly Lys Val Glu 1880 1885
1890 Glu Val Asp Leu Lys Pro Met Lys Glu Lys Asn Ala Lys Glu Glu
1895 1900 1905 Leu Ile Arg Trp Glu Glu Gly Lys Lys Trp Gln Ala Lys
Ile Glu 1910 1915 1920 Gly Ile Arg Asn Lys Leu Lys Glu Lys Glu Gly
Glu Val Phe Thr 1925 1930 1935 Leu Thr Lys Gln Leu Asn Thr Leu Lys
Asp Leu Phe Ala Lys Ala 1940 1945 1950 Asp Lys Glu Lys Leu Thr Leu
Gln Arg Lys Leu Lys Thr Thr Gly 1955 1960 1965 Met Thr Val Asp Gln
Val Leu Gly Ile Arg Ala Leu Glu Ser Glu 1970 1975 1980 Lys Glu Leu
Glu Glu Leu Lys Lys Arg Asn Leu Asp Leu Glu Asn 1985 1990 1995 Asp
Ile Leu Tyr Met Arg Ala His Gln Ala Leu Pro Arg Asp Ser 2000 2005
2010 Val Val Glu Asp Leu His Leu Gln Asn Arg Tyr Leu Gln Glu Lys
2015 2020 2025 Leu His Ala Leu Glu Lys Gln Phe Ser Lys Asp Thr Tyr
Ser Lys 2030 2035 2040 Pro Ser Ile Ser Gly Ile Glu Ser Asp Asp His
Cys Gln Arg Glu 2045 2050 2055 Gln Glu Leu Gln Lys Glu Asn Leu Lys
Leu Ser Ser Glu Asn Ile 2060 2065 2070 Glu Leu Lys Phe Gln Leu Glu
Gln Ala Asn Lys Asp Leu Pro Arg 2075 2080 2085 Leu Lys Asn Gln Val
Arg Asp Leu Lys Glu Met Cys Glu Phe Leu 2090 2095 2100 Lys Lys Glu
Lys Ala Glu Val Gln Arg Lys Leu Gly His Val Arg 2105 2110 2115 Gly
Ser Gly Arg Ser Gly Lys Thr Ile Pro Glu Leu Glu Lys Thr 2120 2125
2130 Ile Gly Leu Met Lys Lys Val Val Glu Lys Val Gln Arg Glu Asn
2135 2140 2145 Glu Gln Leu Lys Lys Ala Ser Gly Ile Leu Thr Ser Glu
Lys Met 2150 2155 2160 Ala Asn Ile Glu Gln Glu Asn Glu Lys Leu Lys
Ala Glu Leu Glu 2165 2170 2175 Lys Leu Lys Ala His Leu Gly His Gln
Leu Ser Met His Tyr Glu 2180 2185 2190 Ser Lys Thr Lys Gly Thr Glu
Lys Ile Ile Ala Glu Asn Glu Arg 2195 2200 2205 Leu Arg Lys Glu Leu
Lys Lys Glu Thr Asp Ala Ala Glu Lys Leu 2210 2215 2220 Arg Ile Ala
Lys Asn Asn Leu Glu Ile Leu Asn Glu Lys Met Thr 2225 2230 2235 Val
Gln Leu Glu Glu Thr Gly Lys Arg Leu Gln Phe Ala Glu Ser 2240 2245
2250 Arg Gly Pro Gln Leu Glu Gly Ala Asp Ser Lys Ser Trp Lys Ser
2255 2260 2265 Ile Val Val Thr Arg Met Tyr Glu Thr Lys Leu Lys Glu
Leu Glu 2270 2275 2280 Thr Asp Ile Ala Lys Lys Asn Gln Ser Ile Thr
Asp Leu Lys Gln 2285 2290 2295 Leu Val Lys Glu Ala Thr Glu Arg Glu
Gln Lys Val Asn Lys Tyr 2300 2305 2310 Asn Glu
Asp Leu Glu Gln Gln Ile Lys Ile Leu Lys His Val Pro 2315 2320 2325
Glu Gly Ala Glu Thr Glu Gln Gly Leu Lys Arg Glu Leu Gln Val 2330
2335 2340 Leu Arg Leu Ala Asn His Gln Leu Asp Lys Glu Lys Ala Glu
Leu 2345 2350 2355 Ile His Gln Ile Glu Ala Asn Lys Asp Gln Ser Gly
Ala Glu Ser 2360 2365 2370 Thr Ile Pro Asp Ala Asp Gln Leu Lys Glu
Lys Ile Lys Asp Leu 2375 2380 2385 Glu Thr Gln Leu Lys Met Ser Asp
Leu Glu Lys Gln His Leu Lys 2390 2395 2400 Glu Glu Ile Lys Lys Leu
Lys Lys Glu Leu Glu Asn Phe Asp Pro 2405 2410 2415 Ser Phe Phe Glu
Glu Ile Glu Asp Leu Lys Tyr Asn Tyr Lys Glu 2420 2425 2430 Glu Val
Lys Lys Asn Ile Leu Leu Glu Glu Lys Val Lys Lys Leu 2435 2440 2445
Ser Glu Gln Leu Gly Val Glu Leu Thr Ser Pro Val Ala Ala Ser 2450
2455 2460 Glu Glu Phe Glu Asp Glu Glu Glu Ser Pro Val Asn Phe Pro
Ile 2465 2470 2475 Tyr 422625DNAHomo sapiens 42actcgaccgg
gctgcgctca ctgcccagcc ggggccccgg gagcctccag gctcccgccc 60gccctgagct
gcggcctccg catggagggg ccactcactc caccaccgct gcagggaggc
120ggagccgccg ctgttccgga gcccggagcc cggcaacacc cgggacacga
gacggcggcg 180cagcggtaca gcgcccgact gctgcaggcc ggctacgagc
ccgagagccc tagattggac 240ctcgctacac acccgacgac accccgttca
gaactatctt cagtggtctt actggcaggt 300gttggtgtcc agatggatcg
ccttcgcagg gctagcatgg cggactacct gatcagcggc 360ggcaccggct
acgtgcccga ggatgggctc accgcgcagc agctcttcgc cagcgccgac
420ggcctcacct acaacgactt cctgattctc ccaggattca tagacttcat
agctgatgag 480gtggacctga cctcagccct gacccggaag atcacgctga
agacgccact gatctcctcc 540cccatggaca ctgtgacaga ggctgacatg
gccattgcca tggctctgat gggaggtatt 600ggtttcattc accacaactg
caccccagag ttccaggcca acgaggtgcg gaaggtcaag 660aagtttgaac
agggcttcat cacggaccct gtggtgctga gcccctcgca cactgtgggc
720gatgtgctgg aggccaagat gcggcatggc ttctctggca tccccatcac
tgagacgggc 780accatgggca gcaagctggt gggcatcgtc acctcccgag
acatcgactt tcttgctgag 840aaggaccaca ccaccctcct cagtgaggtg
atgacgccaa ggattgaact ggtggtggct 900ccagcaggtg tgacgttgaa
agaggcaaat gagatcctgc agcgtagcaa gaaagggaag 960ctgcctatcg
tcaatgattg cgatgagctg gtggccatca tcgcccgcac cgacctgaag
1020aagaaccgag actaccctct ggcctccaag gattcccaga agcagctgct
ctgtggggca 1080gctgtgggca cccgtgagga tgacaaatac cgtctggacc
tgctcaccca ggcgggcgtc 1140gacgtcatag tcttggactc gtcccaaggg
aattcggtgt atcagatcgc catggtgcat 1200tacatcaaac agaagtaccc
ccacctccag gtgattgggg ggaacgtggt gacagcagcc 1260caggccaaga
acctgattga tgctggtgtg gacgggctgc gcgtgggcat gggctgcggc
1320tccatctgca tcacccagga agtgatggcc tgtggtcggc cccagggcac
tgctgtgtac 1380aaggtggctg agtatgcccg gcgctttggt gtgcccatca
tagccgatgg cggcatccag 1440accgtgggac acgtggtcaa ggccctggcc
cttggagcct ccacagtgat gatgggctcc 1500ctgctggccg ccactacgga
ggcccctggc gagtacttct tctcagacgg ggtgcggctc 1560aagaagtacc
ggggcatggg ctcactggat gccatggaga agagcagcag cagccagaaa
1620cgatacttca gcgaggggga taaagtgaag atcgcgcagg gtgtctcggg
ctccatccag 1680gacaaaggat ccattcagaa gttcgtgccc tacctcatag
caggcatcca acacggctgc 1740caggatatcg gggcccgcag cctgtctgtc
cttcggtcca tgatgtactc aggagagctc 1800aagtttgaga agcggaccat
gtcggcccag attgagggtg gtgtccatgg cctgcactct 1860tacgaaaagc
ggctgtactg aggacagcgg tggaggccga ggtggtggag gggatgcacc
1920ccagtgtcca cttttgggca cagcctccct ccataactga gtggtccaca
gatttgcact 1980acgggttctc cagctccttt ccaggcagag aggaggggag
gtcctgaggg gactgctgcc 2040cctcactcgg catcccctgc agagtcagga
ctgctcccgg ggccaggctg ccctgggagc 2100ccccctccga gcccagccag
ccaggctctc aggccctgcg cctgcctcag gtctttcttg 2160ctgcagcctg
ctccagcctg gcccccaccc caggggcagg cggcccctcc tggcttctcc
2220tgtagggcac ctccctgccc ctagcctccc aggaaatggt gctctcctgg
ccctgcctct 2280ggcccttccc gggccgctgc ccctcagcca tgtggcactt
ctgagctcct gacctaggcc 2340aaggggaggt ctctgccccc ttccccggcc
ctgggctacc cttgggtcct gctcctcagg 2400ccgctcccct gtccctggcc
atgggtagga gactgccctg gtcatggccg cctgcctgtc 2460attcctgact
caccaccgtc cccaggtgaa ccattcctcc cttctcctca gctgcagtcg
2520aaggctttaa ctttgcacac ttgggatcac agttgcgtca ttgtgtatta
aatacttgga 2580ataaatcaag caggtctcaa cgcctccact aaaaaaaaaa aaaaa
262543599PRTHomo sapiens 43Met Glu Gly Pro Leu Thr Pro Pro Pro Leu
Gln Gly Gly Gly Ala Ala 1 5 10 15 Ala Val Pro Glu Pro Gly Ala Arg
Gln His Pro Gly His Glu Thr Ala 20 25 30 Ala Gln Arg Tyr Ser Ala
Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 35 40 45 Ser Pro Arg Leu
Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 50 55 60 Leu Ser
Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 65 70 75 80
Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 85
90 95 Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser
Ala 100 105 110 Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly
Phe Ile Asp 115 120 125 Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala
Leu Thr Arg Lys Ile 130 135 140 Thr Leu Lys Thr Pro Leu Ile Ser Ser
Pro Met Asp Thr Val Thr Glu 145 150 155 160 Ala Asp Met Ala Ile Ala
Met Ala Leu Met Gly Gly Ile Gly Phe Ile 165 170 175 His His Asn Cys
Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 180 185 190 Lys Lys
Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 195 200 205
Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 210
215 220 Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu
Val 225 230 235 240 Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala
Glu Lys Asp His 245 250 255 Thr Thr Leu Leu Ser Glu Val Met Thr Pro
Arg Ile Glu Leu Val Val 260 265 270 Ala Pro Ala Gly Val Thr Leu Lys
Glu Ala Asn Glu Ile Leu Gln Arg 275 280 285 Ser Lys Lys Gly Lys Leu
Pro Ile Val Asn Asp Cys Asp Glu Leu Val 290 295 300 Ala Ile Ile Ala
Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 305 310 315 320 Ala
Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 325 330
335 Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly
340 345 350 Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val
Tyr Gln 355 360 365 Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro
His Leu Gln Val 370 375 380 Ile Gly Gly Asn Val Val Thr Ala Ala Gln
Ala Lys Asn Leu Ile Asp 385 390 395 400 Ala Gly Val Asp Gly Leu Arg
Val Gly Met Gly Cys Gly Ser Ile Cys 405 410 415 Ile Thr Gln Glu Val
Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 420 425 430 Tyr Lys Val
Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 435 440 445 Asp
Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 450 455
460 Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu
465 470 475 480 Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu
Lys Lys Tyr 485 490 495 Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys
Ser Ser Ser Ser Gln 500 505 510 Lys Arg Tyr Phe Ser Glu Gly Asp Lys
Val Lys Ile Ala Gln Gly Val 515 520 525 Ser Gly Ser Ile Gln Asp Lys
Gly Ser Ile Gln Lys Phe Val Pro Tyr 530 535 540 Leu Ile Ala Gly Ile
Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 545 550 555 560 Leu Ser
Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 565 570 575
Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 580
585 590 Ser Tyr Glu Lys Arg Leu Tyr 595 442981DNAHomo sapiens
44gctgggtaaa tcccagagtc tcagccgcct aagtgtcttc cccggaggtg agattatctc
60cgcctgtgct ggacacctcc ctttctcctg cagccatgga tgccgctctg ctcctgaacg
120tggaaggggt caagaaaacc attctgcacg ggggcacggg cgagctccca
aacttcatca 180ccggatcccg agtgatcttt catttccgca ccatgaaatg
tgatgaggag cggacagtca 240ttgacgacag tcggcaggtg ggccagccca
tgcacatcat catcggaaac atgttcaagc 300tcgaggtctg ggagatcctg
cttacctcca tgcgggtgca cgaggtggcc gagttctggt 360gcgacaccat
ccacacgggg gtctacccca tcctatcccg gagcctgagg cagatggccc
420agggcaagga ccccacagag tggcacgtgc acacgtgcgg gctggccaac
atgttcgcct 480accacacgct gggctacgag gacctggacg agctgcagaa
ggagcctcag cctctggtct 540ttgtgatcga gctgctgcag gttgatgccc
cgagtgatta ccagagggag acctggaacc 600tgagcaatca tgagaagatg
aaggcggtgc ccgtcctcca cggagaggga aatcggctct 660tcaagctggg
ccgctacgag gaggcctctt ccaagtacca ggaggccatc atctgcctaa
720ggaacctgca gaccaaggag aagccatggg aggtgcagtg gctgaagctg
gagaagatga 780tcaatactct gatcctcaac tactgccagt gcctgctgaa
gaaggaggag tactatgagg 840tgctggagca caccagtgat attctccggc
accacccagg catcgtgaag gcctactacg 900tgcgtgcccg ggctcacgca
gaggtgtgga atgaggccga ggccaaggcg gacctccaga 960aagtgctgga
gctggagccg tccatgcaga aggcggtgcg cagggagctg aggctgctgg
1020agaaccgcat ggcggagaag caggaggagg agcggctgcg ctgccggaac
atgctgagcc 1080agggtgccac gcagcctccc gcagagccac ccacagagcc
acccgcacag tcatccacag 1140agccacctgc agagccaccc acagcaccat
ctgcagagct gtccgcaggg ccccctgcag 1200agccagccac agagccaccc
ccgtccccag ggcactcgct gcagcactga gccccctgag 1260gcccacagcc
acccaggcag ggagcaagtg gcctggtcac ttctggttcg attgaccagg
1320atcgtggtgt cactttttaa aatttaaaat taatttttga aatcaaagtc
agacacaccc 1380atggtaaaaa aaaaaaaaaa aacaatccca agggtacaga
agagcttatg aataaaagta 1440gttttctcct ctacccctct cattccttcc
gtgccatggt tttaattgac cctgttttta 1500attcttctgg tagttttctc
tatttccaag taatctgttt aaatcagttt ctagatttta 1560ccccatgtca
atgacaaatg aggatttgat gctctgatcc tttctcatgc ctgatacccc
1620tccctgtctc cccattttgg atagttacat ttgggggtca tctcggtgat
ttttgtaact 1680ttacgcagga cacttagagc tctctagaat cccactgact
ttagtgggtc ttgatgtagg 1740gtgggcaagc cccgacactg gagcttagcc
tgagagggtt cttggcctcc cccaggaaag 1800atttcaaagg caagcgccag
tggtagggta gaagaaaaca gctgtggtcg ggcacggtgg 1860ctcacgccta
taatcccagc actttgggag gccgaggcgg gtggatcacc tgaggtcagg
1920agttccagac cagcctggcc aacatggtga aacctcatct ctactaaaaa
tacaaaaaaa 1980ctagctgggc gtggtggcgg gcgcctataa tcccagctac
ttgggaggct gaggcaggag 2040aattgattga acctgggagg cggaggttgc
agtgagccaa gatcacgtca ttgcactcca 2100gcctggtcaa caagagtaaa
acttcatctc aaaaaacaaa acaaaacaaa aacaacaaca 2160aaaaacaaaa
gaaaaacaaa caaaaccaaa accaaaacag ctgtattgaa gctgcagtgt
2220tgcagctctg tgactgccct gcagagcagg gctaccccat aggcagcgag
cagcagctca 2280gggcagttct gcagtcagat ttatacccac ttttaattac
atgtagatta aggagctgca 2340tatacaaaga tttctaggga aggagtagta
acttctgggt cctggggtct ttgccacgga 2400acagggcagt atgccagggt
gttgccacgg caatggtaaa ctgacatggc accctggggg 2460tcatgcctta
gggaaagccg cttccactcg cccctgtttt agctcatctt caagttagtc
2520tggtgtccaa gctccaccgc ctgcctcagt ctggtgacct ccttctgtgt
ctgatgagca 2580tggcagcgtt gggaccttcc ccttccaact ctctccctcc
tcttcgtcct ccctaaagga 2640cgggtacgag gaggggctat cacgccagcg
acatcctcta gcaccaccca ggtgtgtggg 2700gtggggcagg ggggcgacga
agtatccagc ccagggccac gtagtcaact gccaagggct 2760tcctgggctt
ctcttctgcc ccagagcttg tctccaccca gcaggggttc ccccagcgct
2820aactgtatcc ctaaagttct gatgtacttt acttttccat cttccttgtt
gttaacatct 2880accttctgct ctgtaagcaa aactaaatct tctgtgcttt
gtccataggt tgattctaca 2940atctgaaaat caataaacag catttgcatg
aaaaaaaaaa a 298145384PRTHomo sapiens 45Met Asp Ala Ala Leu Leu Leu
Asn Val Glu Gly Val Lys Lys Thr Ile 1 5 10 15 Leu His Gly Gly Thr
Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 20 25 30 Val Ile Phe
His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 35 40 45 Ile
Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 50 55
60 Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg
65 70 75 80 Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr
Gly Val 85 90 95 Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala
Gln Gly Lys Asp 100 105 110 Pro Thr Glu Trp His Val His Thr Cys Gly
Leu Ala Asn Met Phe Ala 115 120 125 Tyr His Thr Leu Gly Tyr Glu Asp
Leu Asp Glu Leu Gln Lys Glu Pro 130 135 140 Gln Pro Leu Val Phe Val
Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 145 150 155 160 Asp Tyr Gln
Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 165 170 175 Ala
Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 180 185
190 Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu
195 200 205 Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp
Leu Lys 210 215 220 Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr
Cys Gln Cys Leu 225 230 235 240 Leu Lys Lys Glu Glu Tyr Tyr Glu Val
Leu Glu His Thr Ser Asp Ile 245 250 255 Leu Arg His His Pro Gly Ile
Val Lys Ala Tyr Tyr Val Arg Ala Arg 260 265 270 Ala His Ala Glu Val
Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln 275 280 285 Lys Val Leu
Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu 290 295 300 Leu
Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg 305 310
315 320 Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro
Ala 325 330 335 Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu
Pro Pro Ala 340 345 350 Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser
Ala Gly Pro Pro Ala 355 360 365 Glu Pro Ala Thr Glu Pro Pro Pro Ser
Pro Gly His Ser Leu Gln His 370 375 380 461934DNAHomo sapiens
46gggcacaagc aatcctccct tctcagcttc ctgagtggcc aggactacag aggactgtat
60gctgttctta aggactctct gcttcctgga caagctcaag ctaaggacta catctcccag
120caggctgtgc tctgacagct cttggattta aataggattc tgggctctgc
tcagagtcag 180gctgctgctc agcacccagg acggagagga gcagagaagc
agcagaagca gccaagagct 240ggagccagac caggaacctg agccagagct
ggggttgaag ctggagcagc agcaaaagca 300acagcagcta cagaagttgg
aacgatgctg gtcaccttgg gactgctcac ctccttcttc 360tcgttcctgt
atatggtagc tccatccatc aggaagttct ttgctggtgg agtgtgtaga
420acaaatgtgc agcttcctgg caaggtagtg gtgatcactg gcgccaacac
gggcattggc 480aaggagacgg ccagagagct cgctagccga ggagcccgag
tctatattgc ctgcagagat 540gtactgaagg gggagtctgc tgccagtgaa
atccgagtgg atacaaagaa ctcccaggtg 600ctggtgcgga aattggacct
atccgacacc aaatctatcc gagcctttgc tgagggcttt 660ctggcagagg
aaaagcagct ccatattctg atcaacaatg cgggagtaat gatgtgtcca
720tattccaaga cagctgatgg ctttgaaacc cacctgggag tcaaccacct
gggccacttc 780ctcctcacct acctgctcct ggagcggcta aaggtgtctg
cccctgcacg ggtggttaat 840gtgtcctcgg tggctcacca cattggcaag
attcccttcc acgacctcca gagcgagaag 900cgctacagca ggggttttgc
ctattgccac agcaagctgg ccaatgtgct ttttactcgt 960gagctggcca
agaggctcca aggcaccggg gtcaccacct acgcagtgca cccaggcgtc
1020gtccgctctg agctggtccg gcactcctcc ctgctctgcc tgctctggcg
gctcttctcc 1080ccctttgtca agacggcacg ggagggggcg cagaccagcc
tgcactgcgc cctggctgag 1140ggcctggagc ccctgagtgg caagtacttc
agtgactgca agaggacctg ggtgtctcca 1200agggcccgaa ataacaaaac
agctgagcgc ctatggaatg tcagctgtga gcttctagga 1260atccggtggg
agtagctggt ggaagagctg cagctttatc aggcccaatc catgccataa
1320tgaacaggga ccaaggagaa ggccaaccct aaaggattgt cctcttggcc
agctggtgct 1380gcgaatcctg cctgctctga tcctcttgac ccttctggga
atgtttgcac acctgacact 1440cttgtgagac tggcttatgg catgagttgt
ggacacctat agagtgttct tctctaagac 1500ctggaaagtc agcaaccctc
tgggggcagc aggactgggc agatcccagg ctgggcatgg 1560gggtggcaga
agagcccgag aaattgggtc agttccctca tcagcaccag aggctcagct
1620gaggcaagaa gagcaccatc actgcctatt tctaggggct atacactcca
actcttggtt 1680gatctctttc tttttaaaaa tatttgccac caccctggag
tctagaccaa cacacaaaga 1740tcctggctaa ccctggccta tttagattcc
ttcctctcac
ctggaccttc ccatttcaat 1800catgcagatg gtttcttttt gtaaagagtt
ccgtttgcct ttcaattttt agagaaaata 1860aagactgcat tcatctcaaa
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1920aaaaaaaaaa aaaa
193447316PRTHomo sapiens 47Met Leu Val Thr Leu Gly Leu Leu Thr Ser
Phe Phe Ser Phe Leu Tyr 1 5 10 15 Met Val Ala Pro Ser Ile Arg Lys
Phe Phe Ala Gly Gly Val Cys Arg 20 25 30 Thr Asn Val Gln Leu Pro
Gly Lys Val Val Val Ile Thr Gly Ala Asn 35 40 45 Thr Gly Ile Gly
Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 50 55 60 Arg Val
Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 65 70 75 80
Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 85
90 95 Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly
Phe 100 105 110 Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn
Ala Gly Val 115 120 125 Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly
Phe Glu Thr His Leu 130 135 140 Gly Val Asn His Leu Gly His Phe Leu
Leu Thr Tyr Leu Leu Leu Glu 145 150 155 160 Arg Leu Lys Val Ser Ala
Pro Ala Arg Val Val Asn Val Ser Ser Val 165 170 175 Ala His His Ile
Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 180 185 190 Arg Tyr
Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 195 200 205
Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 210
215 220 Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg
His 225 230 235 240 Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser
Pro Phe Val Lys 245 250 255 Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu
His Cys Ala Leu Ala Glu 260 265 270 Gly Leu Glu Pro Leu Ser Gly Lys
Tyr Phe Ser Asp Cys Lys Arg Thr 275 280 285 Trp Val Ser Pro Arg Ala
Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 290 295 300 Asn Val Ser Cys
Glu Leu Leu Gly Ile Arg Trp Glu 305 310 315 484729DNAHomo sapiens
48agtctaggcc tccgcctccg ttaccctgga gcccaggtta ccgccgctgc cacccaggag
60ccccgatcct cgcctctgtc ccatccttgt gttcaaacct cccgcatctc ggcaacctcg
120gcacccgccc ggcagcctcc gcaggaacca ggcacccgct ctttggcggt
cagacgccga 180ggccccagct gggagtttgg tcctaagagg gaaggcaagg
aggcgggacg ccgcatcggc 240tctgctgaag agcctgcggg ttggaggtgg
gctttgaagt gggcgtggag acggcggggg 300aggtggaggt gcgagtataa
atgatcaacc agaaattatc ttcaaaggaa taaaaccaga 360agtatgtaaa
taaaaagccc aagataaaga aacagaaaag ctgacactac atgaagcaga
420gggcaaaaaa gtttatcttc tggatgccaa tgtgaattgt ggtctacaaa
tacattgtgg 480agaaaataga ttgcacagaa atgaatatta tcaggatctg
aagactgtga aaatgttttt 540cagtattgtc atagtctcct ctggagaaaa
taatctgtga aattatgtga atagagacca 600tttttcaaaa caatggggga
aagagcagga agtccaggta ctgatcaaga aagaaaggca 660ggcaaacacc
attattctta cttatctgat tttgaaacgc cacagtcttc tggccgatca
720tcgctggtca gttcttcacc tgcaagtgtt aggagaaaaa atcctaaaag
acaaacttca 780gatggccaag tacatcacca agcccctcgg aaaccaagcc
ctaagggtct accaaacaga 840aagggagtcc gagtgggatt tcgctcccag
agcctcaata gagagccact tcggaaagat 900actgatcttg ttacaaaacg
gattctgtct gcaagactgc taaaaatcaa tgagttgcag 960aatgaagtat
ctgaactcca ggtcaagtta gctgagctgc taaaagaaaa taaatctttg
1020aaaaggcttc agtacagaca ggagaaagcc ctgaataagt ttgaagatgc
cgaaaatgaa 1080atctcacaac ttatatttcg tcataacaat gagattacag
cactcaaaga acgcttaaga 1140aaatctcaag agaaagaacg ggcaactgag
aaaagggtaa aagatacaga aagtgaacta 1200tttaggacaa aattttcctt
acagaaactg aaagagatct ctgaagctag acacctacct 1260gaacgagatg
atttggcaaa gaaactagtt tcagcagagt taaagttaga tgacaccgag
1320agaagaatta aggagctatc gaaaaacctt gaactgagta ctaacagttt
ccaacgacag 1380ttgcttgctg aaaggaaaag ggcatatgag gctcatgatg
aaaataaagt tcttcaaaag 1440gaggtacagc gactatatca caaattaaag
gaaaaggaga gagaactgga tataaaaaat 1500atatattcta atcgtctgcc
aaagtcctct ccaaataaag agaaagaact tgcattaaga 1560aaaaatgctg
catgccagag tgattttgca gacctgtgta caaaaggagt acaaaccatg
1620gaagacttca agccagaaga atatccttta actccagaaa caattatgtg
ttacgaaaac 1680aaatgggaag aaccaggaca tcttactttg gacttgcaat
ctcaaaagca agacaggcat 1740ggagaagcag ggattctaaa cccaattatg
gaaagagaag aaaaatttgt tacagatgaa 1800gaactccatg tcgtaaaaca
ggaggttgaa aagctggagg atgaatggga aagagaagaa 1860cttgataaaa
agcaaaaaga aaaggcatct ttactggaaa gagaagaaaa gccagagtgg
1920gaaactggaa ggtaccaact aggaatgtat ccaattcaga atatggataa
attgcaagga 1980gaggaagaag aaagactgaa gagagaaatg ctacttgcta
aactgaatga aattgacaga 2040gaactccaag attctcgaaa tctaaaatac
cctgttttgc cattgttacc tgattttgaa 2100tcaaaactac actccccaga
gagaagcccc aaaacataca ggttctctga atcctcagag 2160agattattta
atgggcatca tttgcaagac atcagtttct caactccaaa aggagaaggt
2220cagaattcag gaaatgttag aagtccagcc tcccctaatg agttcgcatt
tggtagctac 2280gtgccttcgt ttgcaaaaac atcagagagg tcaaatccat
ttagtcaaaa aagtagtttt 2340ttggatttcc aaagaaacag tatggaaaaa
cttagtaaag atggtgtaga tttaattaca 2400agaaaagaga aaaaagctaa
tttgatggaa cagttatttg gtgccagtgg tagcagcacc 2460atttcctcca
aaagcagtga cccaaattct gtggcttcca gtaaaggaga cattgaccct
2520ctaaattttc tccctgggaa taaaggcagc agagatcaag aacatgatga
agatgaaggc 2580tttttcctca gtgaaggaag aagttttaat ccaaataggc
accgattaaa acatgcagac 2640gataaaccag cagtaaaagc agctgattct
gtagaagatg aaattgaaga agtagcactg 2700agatgactga ctagagtata
cattttttct aattgtaaat attgaaatat tttaatacag 2760tatttattat
aaacatttag actttttaat gctaaaatgt ccttattaag gaatgatttt
2820taatagctaa atacaatgca gttaaaaaga agtagatcat acatacacca
catagatagt 2880ttgccaagaa tgaaggaggc ttttttgaat gaaaccaaaa
ataaaaatat gtcttgaaaa 2940atgaaataga ttttaactct tcatccagtg
ctatggcaag tttaactgca ctggaggtgg 3000tattcctttt ctacttttat
tcctatttat gtatttattt ttaatcatat tctcactgtg 3060ctaaatacag
tcttcccact aattgttgaa tgaaaattaa gggtgaaagt ctgtgttggg
3120aagtgtagct ccggatggtg gagaaccagt gcttcttagg agcccttccc
tttatggata 3180gggccagggg tccctatctt acgtggcagt cctaagctac
tcttgagtga tagcagtcac 3240aacattggga tttcccattc ctctgaaagt
acccacagct aaacactact catttcccaa 3300tttcagtatt tactgaaatc
acttacctac aattctgtta gaatattatg ttgagttcgg 3360aagacatttc
tctgtttgca aggacagtta gttgctctct gtcatagccc gcagaagctt
3420ggctacagtg taattcctct ccttgttctc ctacactctt tgtatctcag
tgactgggtg 3480taagatttca tgccaaatgc aaggaatagt ggaaatacat
accaactgca aagaatagaa 3540aaactttatc ccaatatatt atagaaagat
cttcagttca attatgtcca gagtaatata 3600atttggcaat gttaatgctt
ttaagatttg aacttgtcct caaaccaagg agacaacaat 3660agtgtaatac
tattggactt acaggattag ttttaaagca actttgaata gaagtgtttc
3720agacatagga cttctgcctt gttgactaga gtggatagtt ttctgtttaa
atgcattggt 3780cttttggctg tttgtaattc acttcagctt atagagaagt
tgatgacctt ggatcatgct 3840gggtatgatt ggtctttaaa aagcagtaat
ataccaccag cccaaggaga aaacattgtt 3900aaaatgaaga gtggtggaaa
tagtgtgttg ggaagaataa aaaatttaga ttggcactta 3960ttctaaagtg
agctgttttt ttcaagaatt tactagcatt tgctcgtagt atgatttctg
4020acgccagtca tatatactga tgaggggaag gagttactgt gttattctga
gttcttataa 4080atgcatatta ttgaatttca ttgcatgact atttgtcaag
acttacctgg ttaggtctcc 4140aattaaaaga tgtaccacct gtcatcttct
aaattgtgtt cctttcattt attgggaaca 4200gaatctctca aaagtgctaa
actatattaa aaagttttct taatagattt gtatgtctga 4260tatgtataac
catttactat aatatgttgc aaatcattct aatatatgta aaacaatatt
4320atttgtaatg cagttattgg taaaatatta tgtaatgtta attttgttcc
tagctgctaa 4380tttttctgcc aaaagtattc taattttcag gttgttttaa
aggcttttaa aactttttag 4440ttaagttttt tattcacgtc atttaaatta
gttttttgct ttttttctac ctgataatct 4500ctttaacaag atgcaacaag
acagaattat taaaattaaa cctaaagtta agttacagat 4560ttaaaggcat
tatgatatta agcattaaaa ttggagatta aaatgtacaa aacagggttt
4620tccttatgaa caaaccttac agggtaaatt gttttttttt ctaaatgtca
ttaaatttat 4680ttgtactcag aactgttact aataaaaatt aaaaatgcaa
aaaaaaaaa 472949697PRTHomo sapiens 49Met Gly Glu Arg Ala Gly Ser
Pro Gly Thr Asp Gln Glu Arg Lys Ala 1 5 10 15 Gly Lys His His Tyr
Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser 20 25 30 Ser Gly Arg
Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 35 40 45 Lys
Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 50 55
60 Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg
65 70 75 80 Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg
Lys Asp 85 90 95 Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg
Leu Leu Lys Ile 100 105 110 Asn Glu Leu Gln Asn Glu Val Ser Glu Leu
Gln Val Lys Leu Ala Glu 115 120 125 Leu Leu Lys Glu Asn Lys Ser Leu
Lys Arg Leu Gln Tyr Arg Gln Glu 130 135 140 Lys Ala Leu Asn Lys Phe
Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 145 150 155 160 Ile Phe Arg
His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 165 170 175 Lys
Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 180 185
190 Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu
195 200 205 Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala
Lys Lys 210 215 220 Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu
Arg Arg Ile Lys 225 230 235 240 Glu Leu Ser Lys Asn Leu Glu Leu Ser
Thr Asn Ser Phe Gln Arg Gln 245 250 255 Leu Leu Ala Glu Arg Lys Arg
Ala Tyr Glu Ala His Asp Glu Asn Lys 260 265 270 Val Leu Gln Lys Glu
Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 275 280 285 Glu Arg Glu
Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 290 295 300 Ser
Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 305 310
315 320 Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr
Met 325 330 335 Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu
Thr Ile Met 340 345 350 Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His
Leu Thr Leu Asp Leu 355 360 365 Gln Ser Gln Lys Gln Asp Arg His Gly
Glu Ala Gly Ile Leu Asn Pro 370 375 380 Ile Met Glu Arg Glu Glu Lys
Phe Val Thr Asp Glu Glu Leu His Val 385 390 395 400 Val Lys Gln Glu
Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 405 410 415 Leu Asp
Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 420 425 430
Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 435
440 445 Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys
Arg 450 455 460 Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu
Leu Gln Asp 465 470 475 480 Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro
Leu Leu Pro Asp Phe Glu 485 490 495 Ser Lys Leu His Ser Pro Glu Arg
Ser Pro Lys Thr Tyr Arg Phe Ser 500 505 510 Glu Ser Ser Glu Arg Leu
Phe Asn Gly His His Leu Gln Asp Ile Ser 515 520 525 Phe Ser Thr Pro
Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 530 535 540 Pro Ala
Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 545 550 555
560 Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe
565 570 575 Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp
Gly Val 580 585 590 Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu
Met Glu Gln Leu 595 600 605 Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser
Ser Lys Ser Ser Asp Pro 610 615 620 Asn Ser Val Ala Ser Ser Lys Gly
Asp Ile Asp Pro Leu Asn Phe Leu 625 630 635 640 Pro Gly Asn Lys Gly
Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 645 650 655 Phe Phe Leu
Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 660 665 670 Lys
His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 675 680
685 Asp Glu Ile Glu Glu Val Ala Leu Arg 690 695 503771DNAHomo
sapiens 50ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt
agggggcctt 60ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg
cgtttacgga 120cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg
aacaaatgat gtttaaccac 180acaaaaatga aaatccaatg gttggatatc
cattccaaat acacaaaggc aacggataag 240tgatccgggc caggcacaga
aggccatgca cccgtaggat tgcactcaga gctcccaaat 300gcataggaat
agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc atgggtgttt
360catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga
tggtggtgac 420tggactatac acttacacac ggtagcgatg gtacactttg
tattatgtat attttaccac 480gatcttttta aagtgtcaaa ggcaaatggc
caaatggttc cttgtcctat agctgtagca 540gccatcggct gttagtgaca
aagcccctga gtcaagatga cagcagcccc cataactcct 600aatcggctct
cccgcgtgga gtcatttagg agtagtcgca ttagagacaa gtccaacatc
660taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact
ccgggcagag 720cagagggcgc tgacattggg gcccggcctg gcttgggtcc
ctctggcctt tccccagggg 780ccctctttcc ttggggcttt cttgggccgc
cactgctccc gctcctctcc ccccatccca 840ccccctcacc ccctcgttct
tcatatcctt ctctagtgct ccctccactt tcatccaccc 900ttctgcaaga
gtgtgggacc acaaatgagt tttcacctgg cctggggaca cacgtgcccc
960cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat
gggacttgat 1020cttctgttag ccctaatcat caattagcag agccggtgaa
ggtgcagaac ctaccgcctt 1080tccaggcctc ctcccacctc tgccacctcc
actctccttc ctgggatgtg ggggctggca 1140cacgtgtggc ccagggcatt
ggtgggattg cactgagctg ggtcattagc gtaatcctgg 1200acaagggcag
acagggcgag cggagggcca gctccggggc tcaggcaagg ctgggggctt
1260cccccagaca ccccactcct cctctgctgg acccccactt catagggcac
ttcgtgttct 1320caaagggctt ccaaatagca tggtggcctt ggatgcccag
ggaagcctca gagttgctta 1380tctccctcta gacagaaggg gaatctcggt
caagagggag aggtcgccct gttcaaggcc 1440acccagccag ctcatggcgg
taatgggaca aggctggcca gccatcccac cctcagaagg 1500gacccggtgg
ggcaggtgat ctcagaggag gctcacttct gggtctcaca ttcttggatc
1560cggttccagg cctcggccct aaatagtctc cctgggcttt caagagaacc
acatgagaaa 1620ggaggattcg ggctctgagc agtttcacca cccacccccc
agtctgcaaa tcctgacccg 1680tgggtccacc tgccccaaag gcggacgcag
gacagtagaa gggaacagag aacacataaa 1740cacagagagg gccacagcgg
ctcccacagt caccgccacc ttcctggcgg ggatgggtgg 1800ggcgtctgag
tttggttccc agcaaatccc tctgagccgc ccttgcgggc tcgcctcagg
1860agcaggggag caagaggtgg gaggaggagg tctaagtccc aggcccaatt
aagagatcag 1920gtagtgtagg gtttgggagc ttttaaggtg aagaggcccg
ggctgatccc acaggccagt 1980ataaagcgcc gtgaccctca ggtgatgcgc
cagggccggc tgccgtcggg gacagggctt 2040tccatagcca tgctagagga
tccggtactc gaggaactga aaaaccagaa agttaactgg 2100taagtttagt
ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa
2160gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt
gttacttctg 2220ctctaaaagc tgcggaattg tacccgcggc cgcgggacag
ggctttccat agccatggcc 2280cagcagtgga gcctccaaag gctcgcaggc
cgccatccgc aggacagcta tgaggacagc 2340acccagtcca gcatcttcac
ctacaccaac agcaactcca ccagaggccc cttcgaaggc 2400ccgaattacc
acatcgctcc cagatgggtg taccacctca ccagtgtctg gatgatcttt
2460gtggtcactg catccgtctt cacaaatggg cttgtgctgg cggccaccat
gaagttcaag 2520aagctgcgcc acccgctgaa ctggatcctg gtgaacctgg
cggtcgctga cctagcagag 2580accgtcatcg ccagcactat cagcattgtg
aaccaggtct ctggctactt cgtgctgggc 2640caccctatgt gtgtcctgga
gggctacacc gtctccctgt gtgggatcac aggtctctgg 2700tctctggcca
tcatttcctg ggagagatgg atggtggtct gcaagccctt tggcaatgtg
2760agatttgatg ccaagctggc catcgtgggc attgccttct cctggatctg
gtctgctgtg 2820tggacagccc cgcccatctt tggttggagc aggtactggc
cccacggcct gaagacttca 2880tgcggcccag acgtgttcag cggcagctcg
taccccgggg tgcagtctta catgattgtc 2940ctcatggtca cctgctgcat
catcccactc gctatcatca tgctctgcta cctccaagtg 3000tggctggcca
tccgagcggt ggcaaagcag cagaaagagt ctgaatccac ccagaaggca
3060gagaaggaag tgacgcgcat ggtggtggtg atgatctttg cgtactgcgt
ctgctgggga 3120ccctacacct tcttcgcatg ctttgctgct gccaaccctg
gttacgcctt ccaccctttg 3180atggctgccc tgccggccta ctttgccaaa
agtgccacta tctacaaccc cgttatctat 3240gtctttatga accggcagtt
tcgaaactgc atcttgcagc ttttcgggaa gaaggttgac 3300gatggctctg
aactctccag cgcctccaaa acggaggtct caactgtgtc ctcgacccag
3360gtagggccta actgaggtct gcctcctacc catcccgccc accggggctt
tggccacctc
3420tcctttcccc ctccttctcc atccctgtaa aataaatgta atttatcttt
gccaaaacca 3480aaaaaaacgg aattcgtaat catgtcatag ctgtttcctg
tgtgaaattg ttatccgctc 3540acaattccac acaacatacg aggcggccgc
gcggatccag acatgataag atacattgat 3600gagtttggac aaaccacaac
tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt 3660gatgctattg
ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat
3720tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta g
37715136DNAArtificial SequenceSynthetic 51gacttgatct tctgttagcc
ctaatcatca attagc 36
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