U.S. patent application number 14/652066 was filed with the patent office on 2015-11-26 for compositions, methods of administration and uses for trivalent dengue virus formulations. The applicant listed for this patent is TAKEDA VACCINES, INC.. Invention is credited to Joseph N. Brewoo, Jorge E. Osorio, Charalambos D. Partidos, Dan T. Stinchcomb.
Application Number | 20150335727 14/652066 |
Document ID | / |
Family ID | 50934851 |
Filed Date | 2015-11-26 |
United States Patent Application | 20150335727 |
Kind Code | A1 |
Stinchcomb; Dan T. ; et al. | November 26, 2015 |
Embodiments of the present invention report compositions and methods for vaccinating a subject using trivalent dengue virus vaccine compositions. In some embodiments, more than one vaccine composition may be administered to a subject in different anatomical locations in order to induce a rapid response to at least three of four dengue virus serotypes. In certain embodiments, administration of a trivalent dengue virus vaccine composition can be combined with administration of a monovalent dengue virus vaccine composition.
Inventors: | Stinchcomb; Dan T.; (Fort Collins, CO) ; Brewoo; Joseph N.; (Madison, WI) ; Osorio; Jorge E.; (Mount Horeb, WI) ; Partidos; Charalambos D.; (Chicago, IL) | ||||||||||
Applicant: |
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Family ID: | 50934851 | ||||||||||
Appl. No.: | 14/652066 | ||||||||||
Filed: | December 7, 2013 | ||||||||||
PCT Filed: | December 7, 2013 | ||||||||||
PCT NO: | PCT/US13/73757 | ||||||||||
371 Date: | June 12, 2015 |
Current U.S. Class: | 424/218.1 |
Current CPC Class: | A61K 45/06 20130101; A61P 31/14 20180101; Y02A 50/30 20180101; A61K 2039/5254 20130101; Y02A 50/386 20180101; A61K 2039/70 20130101; A61P 37/04 20180101; A61K 2039/5256 20130101; A61K 39/12 20130101; C12N 2770/24134 20130101 |
International Class: | A61K 39/12 20060101 A61K039/12; A61K 45/06 20060101 A61K045/06 |
Sequence CWU 1
1
33129PRTArtificialDerived from Dengue virus serotype 2 (DENV-2)
1Asn Ile Leu Asn Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu 1
5 10 15 Ile Pro Thr Val Met Ala Phe His Leu Thr Thr Arg Asn 20 25
229PRTArtificialDerived from Dengue virus serotype 4 (DENV-4 WT)
2Asn Ile Leu Asn Gly Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu 1
5 10 15 Ile Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp 20 25
329PRTArtificialDerived from Dengue virus seroptype 4 (DENVax-
4ori) 3Asn Ile Leu Asn Arg Arg Arg Ser Ser Ala Gly Met Ile Ile Met
Leu 1 5 10 15 Ile Pro Thr Val Met Ala Phe His Leu Thr Thr Arg Asp
20 25 429PRTArtificialDerived from Dengue virus serotype 4 (DENVax-
4b) 4Asn Ile Leu Asn Arg Arg Arg Ser Ser Thr Ile Thr Leu Leu Cys
Leu 1 5 10 15 Ile Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp
20 25 529PRTArtificialDerived from Dengue virus serotype 4 (DENVax-
4c) 5Asn Ile Leu Asn Gly Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys
Leu 1 5 10 15 Ile Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp
20 25 628PRTArtificialDerived from Dengue virus serotype 4 (DENVax-
4d) 6Ile Leu Asn Gly Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu
Ile 1 5 10 15 Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp 20 25
710722DNAArtificialDengue virus chimeric construct DENVax-4e
7agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta
60gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctcaa cgataacatt gctgtacttg
420attcccaccg taatggcgtt tcacttgtca acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtgaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg
aaaacgatct ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa
catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt
2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg
gaattcgttg 2880gaagttgaag actatggctt tggagtattc accaccaata
tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc
atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg atatgggtta
ttggatagaa agtgcactca atgacacatg gaagatagag 3060aaagcctctt
tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc
3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc
agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa ataacaggac
catggcatct aggtaagctt 3240gagatggact ttgatttctg tgatggaaca
acagtggtag tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac
aaccactgcc tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca
cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg
3420gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt
cacagctgga 3480catgggcagg tcgacaactt ttcactagga gtcttgggaa
tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat
gcaatactac tagttgcagt ttcttttgtg 3600acattgatca cagggaacat
gtcctttaga gacctgggaa gagtgatggt tatggtaggc 3660gccactatga
cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
caaggaattg 3780atgatgacta ctataggaat tgtactcctc tcccagagca
ccataccaga gaccattctt 3840gagttgactg atgcgttagc cttaggcatg
atggtcctca aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac
tatcatggct atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat
ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc
4020ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat
caaaggtctc 4080aatccaacag ctatttttct aacaaccctc tcaagaacca
gcaagaaaag gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg
gtgagcattt tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg
accattagtg gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac
gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac
4320caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga
agatggtagc 4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca
tactcattag aacaggattg 4440ctggtgatct caggactttt tcctgtatca
ataccaatca cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg
ggccggagta ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg
aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat
4620tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg
gcatgtcaca 4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac
catcatgggc ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg
aagttagaag gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact
ggagcctgga aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca
aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga
4920acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta
tggtaatggt 4980gttgttacaa ggagtggagc atatgtgagt gctatagccc
agactgaaaa aagcattgaa 5040gacaacccag agatcgaaga tgacattttc
cgaaagagaa gactgaccat catggacctc 5100cacccaggag cgggaaagac
gaagagatac cttccggcca tagtcagaga agctataaaa 5160cggggtttga
gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa
5220gcccttagag gacttccaat aagataccag accccagcca tcagagctgt
gcacaccggg 5280cgggagattg tggacctaat gtgtcatgcc acatttacca
tgaggctgct atcaccagtt 5340agagtgccaa actacaacct gattatcatg
gacgaagccc atttcacaga cccagcaagt 5400atagcagcta gaggatacat
ctcaactcga gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca
ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata
5520gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg
ggtcacggat 5580tttaaaggga agactgtttg gttcgttcca agtataaaag
caggaaatga tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata
caactcagta ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa
tgattgggac ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt
tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata
5820ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac
ccactctagt 5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa
atgagaatga ccagtacata 5940tacatggggg aacctctgga aaatgatgaa
gactgtgcac actggaaaga agctaaaatg 6000ctcctagata acatcaacac
gccagaagga atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg
atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt
6120gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt
ggcagctgaa 6180ggcatcaact acgcagacag aaggtggtgt tttgatggag
tcaagaacaa ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca
aaagaagggg aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat
ctattctgac ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa
gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc
6420ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca
cacggctgag 6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc
cggagaccct ggagacattg 6540cttttactga cacttctggc tacagtcacg
ggagggatct ttttattctt gatgagcgca 6600aggggcatag ggaagatgac
cctgggaatg tgctgcataa tcacggctag catcctccta 6660tggtacgcac
aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc
6720atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa
ccaactgacc 6780tacgttgtca tagccatcct cacagtggtg gccgcaacca
tggcaaacga gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg
ggaagcattg caacccagca acccgagagc 6900aacatcctgg acatagatct
acgtcctgca tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta
caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta
7020acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg
gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc attggatgct
actcacaagt caaccccata 7140actctcacag cagctctttt cttattggta
gcacattatg ccatcatagg gccaggactc 7200caagcaaaag caaccagaga
agctcagaaa agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg
gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa
7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt
gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc ttagctaccg
ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact
accattgcgg tgtcaatggc taacattttt 7500agagggagtt acttggccgg
agctggactt ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg
gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg
7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca
ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg
accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag
agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag
aggaggctgg tcatactatt gtggaggact aaagaatgta 7860agagaagtca
aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca
7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt
catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat
caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta
gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa
cccatatatg ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat
atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag
8220atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat
gatttcaagg 8280atgttgatca acagatttac aatgagatac aagaaagcca
cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt
gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat
aaagcaagag catgaaacat catggcacta tgaccaagac 8460cacccataca
aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca
8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt
cgtccccatg 8580gtgacacaga tggcaatgac agacacgact ccatttggac
aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa
gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga
attagggaag aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa
gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac
8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct
ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg
tgtacaacat gatgggaaaa 8940agagagaaga agctagggga attcggcaag
gcaaaaggca gcagagccat atggtacatg 9000tggcttggag cacgcttctt
agagtttgaa gccctaggat tcttaaatga agatcactgg 9060ttctccagag
agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac
9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga
caccgcagga 9180tgggatacaa gaatcacact agaagaccta aaaaatgaag
aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc
attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac
accaagaggc acagtaatgg acatcatatc gagaagagac 9360caaagaggta
gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc
9420caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca
cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg
ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg
aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat
gggaaagatt aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga
atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc
9720atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact
gattggcaga 9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga
cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc
cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc
atcacattgg gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac
atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg
10020attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga
ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc ggctcattga
ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca agcagcaata
aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag attacatgcc
atccatgaaa agattcagaa gagaagagga agaagcagga 10260gttctgtggt
agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc
10320catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta
aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc
tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg
gaagctgtac gcatggcgta gtggactagc 10500ggttagagga gacccctccc
ttacaaatcg cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc
tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag
10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat
tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tc
10722810722DNAArtificialDengue virus chimeric construct DENVax-4h
8agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta
60gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtaaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc
2700aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga
gctgaagtat 2760tcatggaaaa catggggcaa agcaaaaatg ctctctacag
agtctcataa ccagaccttt 2820ctcattgatg gccccgaaac agcagaatgc
cccaacacaa atagagcttg gaattcgttg 2880gaagttgaag actatggctt
tggagtattc accaccaata tatggctaaa attgaaagaa 2940aaacaggatg
tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc
3000gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg
gaagatagag 3060aaagcctctt tcattgaagt taaaaactgc cactggccaa
aatcacacac cctctggagc 3120aatggagtgc tagaaagtga gatgataatt
ccaaagaatc tcgctggacc agtgtctcaa 3180cacaactata gaccaggcta
ccatacacaa ataacaggac catggcatct aggtaagctt 3240gagatggact
ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat
3300agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga
atggtgctgc 3360cgatcttgca cattaccacc gctaagatac agaggtgagg
atgggtgctg gtacgggatg 3420gaaatcagac cattgaagga gaaagaagag
aatttggtca actccttggt cacagctgga 3480catgggcagg tcgacaactt
ttcactagga gtcttgggaa tggcattgtt cctggaggaa 3540atgcttagga
cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg
3600acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt
tatggtaggc 3660gccactatga cggatgacat aggtatgggc gtgacttatc
ttgccctact agcagccttc 3720aaagtcagac caacttttgc agctggacta
ctcttgagaa agctgacctc caaggaattg 3780atgatgacta ctataggaat
tgtactcctc tcccagagca ccataccaga gaccattctt 3840gagttgactg
atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa
3900aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc
agtgatatta 3960caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg
tgtccgtttc cccactgttc 4020ttaacatcct cacagcaaaa aacagattgg
ataccattag cattgacgat caaaggtctc 4080aatccaacag ctatttttct
aacaaccctc tcaagaacca gcaagaaaag gagctggcca 4140ttaaatgagg
ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa
4200aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt
gtgctacgtg 4260ctcactggac gatcggccga tttggaactg gagagagcag
ccgatgtcaa atgggaagac 4320caggcagaga tatcaggaag cagtccaatc
ctgtcaataa caatatcaga agatggtagc 4380atgtcgataa aaaatgaaga
ggaagaacaa acactgacca tactcattag aacaggattg 4440ctggtgatct
caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg
4500tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc
cccacccatg 4560ggaaaggctg aactggaaga tggagcctat agaattaagc
aaaaagggat tcttggatat 4620tcccagatcg gagccggagt ttacaaagaa
ggaacattcc atacaatgtg gcatgtcaca 4680cgtggcgctg ttctaatgca
taaaggaaag aggattgaac catcatgggc ggacgtcaag 4740aaagacctaa
tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa
4800gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca
aacgaaacct 4860ggtcttttca aaaccaacgc cggaacaata ggtgctgtat
ctctggactt ttctcctgga 4920acgtcaggat ctccaattat cgacaaaaaa
ggaaaagttg tgggtcttta tggtaatggt 4980gttgttacaa ggagtggagc
atatgtgagt gctatagccc agactgaaaa aagcattgaa 5040gacaacccag
agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc
5100cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga
agctataaaa 5160cggggtttga gaacattaat cttggccccc actagagttg
tggcagctga aatggaggaa 5220gcccttagag gacttccaat aagataccag
accccagcca tcagagctgt gcacaccggg 5280cgggagattg tggacctaat
gtgtcatgcc acatttacca tgaggctgct atcaccagtt 5340agagtgccaa
actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt
5400atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc
tgggattttt 5460atgacagcca ctcccccggg aagcagagac ccatttcctc
agagcaatgc accaatcata 5520gatgaagaaa gagaaatccc tgaacgctcg
tggaattccg gacatgaatg ggtcacggat 5580tttaaaggga agactgtttg
gttcgttcca agtataaaag caggaaatga tatagcagct 5640tgcctgagga
aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag
5700tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat
ttcagaaatg 5760ggtgccaatt tcaaggctga gagggttata gaccccagac
gctgcatgaa accagtcata 5820ctaacagatg gtgaagagcg ggtgattctg
gcaggaccta tgccagtgac ccactctagt 5880gcagcacaaa gaagagggag
aataggaaga aatccaaaaa atgagaatga ccagtacata 5940tacatggggg
aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg
6000ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga
accagagcgt 6060gaaaaggtgg atgccattga tggcgaatac cgcttgagag
gagaagcaag gaaaaccttt 6120gtagacttaa tgagaagagg agacctacca
gtctggttgg cctacagagt ggcagctgaa 6180ggcatcaact acgcagacag
aaggtggtgt tttgatggag tcaagaacaa ccaaatccta 6240gaagaaaacg
tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc
6300agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt
taaggaattt 6360gcagccggaa gaaagtctct gaccctgaac ctaatcacag
aaatgggtag gctcccaacc 6420ttcatgactc agaaggcaag agacgcactg
gacaacttag cagtgctgca cacggctgag 6480gcaggtggaa gggcgtacaa
ccatgctctc agtgaactgc cggagaccct ggagacattg 6540cttttactga
cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgca
6600aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag
catcctccta 6660tggtacgcac aaatacagcc acactggata gcagcttcaa
taatactgga gttttttctc 6720atagttttgc ttattccaga acctgaaaaa
cagagaacac cccaagacaa ccaactgacc 6780tacgttgtca tagccatcct
cacagtggtg gccgcaacca tggcaaacga gatgggtttc 6840ctagaaaaaa
cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc
6900aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc
cgtggccaca 6960acatttgtta caccaatgtt gagacatagc attgaaaatt
cctcagtgaa tgtgtcccta 7020acagctatag ccaaccaagc cacagtgtta
atgggtctcg ggaaaggatg gccattgtca 7080aagatggaca tcggagttcc
ccttctcgcc attggatgct actcacaagt caaccccata 7140actctcacag
cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc
7200caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat
gaaaaaccca 7260actgtcgatg gaataacagt gattgaccta gatccaatac
cttatgatcc aaagtttgaa 7320aagcagttgg gacaagtaat gctcctagtc
ctctgcgtga ctcaagtatt gatgatgagg 7380actacatggg ctctgtgtga
ggctttaacc ttagctaccg ggcccatctc cacattgtgg 7440gaaggaaatc
cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt
7500agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa
cacaaccaac 7560acaagaaggg gaactggcaa cataggagag acgcttggag
agaaatggaa aagccgattg 7620aacgcattgg gaaaaagtga attccagatc
tacaagaaaa gtggaatcca ggaagtggat 7680agaaccttag caaaagaagg
cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga 7740ggctcagcaa
aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta
7800gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact
aaagaatgta 7860agagaagtca aaggcctaac aaaaggagga ccaggacacg
aagaacccat ccccatgtca 7920acatatgggt ggaatctagt gcgtcttcaa
agtggagttg acgttttctt catcccgcca 7980gaaaagtgtg acacattatt
gtgtgacata ggggagtcat caccaaatcc cacagtggaa 8040gcaggacgaa
cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa
8100ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat
ggaagcacta 8160caaaggaaat atggaggagc cttagtgagg aatccactct
cacgaaactc cacacatgag 8220atgtactggg tatccaatgc ttccgggaac
atagtgtcat cagtgaacat gatttcaagg 8280atgttgatca acagatttac
aatgagatac aagaaagcca cttacgagcc ggatgttgac 8340ctcggaagcg
gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt
8400gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta
tgaccaagac 8460cacccataca aaacgtgggc ataccatggt agctatgaaa
caaaacagac tggatcagca 8520tcatccatgg tcaacggagt ggtcaggctg
ctgacaaaac cttgggacgt cgtccccatg 8580gtgacacaga tggcaatgac
agacacgact ccatttggac aacagcgcgt ttttaaagag 8640aaagtggaca
cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca
8700gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg
caccagagaa 8760gaattcacaa gaaaggtgag aagcaatgca gccttggggg
ccatattcac tgatgagaac 8820aagtggaagt cggcacgtga ggctgttgaa
gatagtaggt tttgggagct ggttgacaag 8880gaaaggaatc tccatcttga
aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa 8940agagagaaga
agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg
9000tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga
agatcactgg 9060ttctccagag agaactccct gagtggagtg gaaggagaag
ggctgcacaa gctaggttac 9120attctaagag acgtgagcaa gaaagaggga
ggagcaatgt atgccgatga caccgcagga 9180tgggatacaa gaatcacact
agaagaccta aaaaatgaag aaatggtaac aaaccacatg 9240gaaggagaac
acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg
9300gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc
gagaagagac 9360caaagaggta gtggacaagt tggcacctat ggactcaata
ctttcaccaa tatggaagcc 9420caactaatca gacagatgga gggagaagga
gtctttaaaa gcattcagca cctaacaatc 9480acagaagaaa tcgctgtgca
aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga 9540atggccatca
gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct
9600ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg
ggaaccttca 9660agaggatgga atgattggac acaagtgccc ttctgttcac
accatttcca tgagttaatc 9720atgaaagacg gtcgcgtact cgttgttcca
tgtagaaacc aagatgaact gattggcaga 9780gcccgaatct cccaaggagc
agggtggtct ttgcgggaga cggcctgttt ggggaagtct 9840tacgcccaaa
tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat
9900gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac
ctggtccata 9960catgctaaac atgaatggat gacaacggaa gacatgctga
cagtctggaa cagggtgtgg 10020attcaagaaa acccatggat ggaagacaaa
actccagtgg aatcatggga ggaaatccca 10080tacttgggga aaagagaaga
ccaatggtgc ggctcattga ttgggttaac aagcagggcc 10140acctgggcaa
agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa
10200gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga
agaagcagga 10260gttctgtggt agaaagcaaa actaacatga aacaaggcta
gaagtcaggt cggattaagc 10320catagtacgg aaaaaactat gctacctgtg
agccccgtcc aaggacgtta aaagaagtca 10380ggccatcata aatgccatag
cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg 10440tgtaaaaaat
ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc
10500ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa
ggcgagatga 10560agctgtagtc tcgctggaag gactagaggt tagaggagac
ccccccgaaa caaaaaacag 10620catattgacg ctgggaaaga ccagagatcc
tgctgtctcc tcagcatcat tccaggcaca 10680gaacgccaga aaatggaatg
gtgctgttga atcaacaggt tc 10722910722DNAArtificialDengue virus
chimeric construct DENVax-4i 9agttgttagt ctacgtggac cgacaaagac
agattctttg agggagctaa gctcaatgta 60gttctaacag ttttttaatt agagagcaga
tctctgatga ataaccaacg gaaaaaggcg 120aaaaacacgc ctttcaatat
gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag 180ctgacaaaga
gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg
240gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat
attgaagaga 300tggggaacaa ttaaaaaatc aaaagctatt aatgttttga
gagggttcag gaaagagatt 360ggaaggatgc tgaacatctt gaataggaga
cgcagctctg caggcatgat cattatgctg 420attccaacag tgatggcgtt
ccatttaacc acgcgtgatg gcgaacccct catgatagtg 480gcaaaacatg
aaagggggag acctctcttg tttaagacaa cagaggggat caacaaatgc
540actctcattg ccatggactt gggtgaaatg tgtgaggaca ctgtcacgta
taaatgcccc 600ttactggtca ataccgaacc tgaagacatt gattgctggt
gcaatctcac gtctacctgg 660gtcatgtatg ggacatgcac ccagagcgga
gaacggagac gagagaagcg ctcagtagct 720ttaacaccac attcaggaat
gggattggaa acaagagctg agacatggat gtcatcggaa 780ggggcttgga
agcatgctca gagagtagag agctggatac tcagaaaccc aggattcgcg
840ctcttggcag gatttatggc ttatatgatt gggcaaacag gaatccagcg
aactgtcttc 900tttgtcctaa tgatgctggt cgccccatcc tacggaatgc
gatgcgtagg agtaggaaac 960agagactttg tggaaggagt ctcaggtgga
gcatgggtcg atctggtgct agaacatgga 1020ggatgcgtca caaccatggc
ccagggaaaa ccaaccttgg attttgaact gactaagaca 1080acagccaagg
aagtggctct gttaagaacc tattgcattg aagcctcaat atcaaacata
1140accacggcaa caagatgtcc aacgcaagga gagccttatc taaaagagga
acaagaccaa 1200cagtacattt gccggagaga tgtggtagac agagggtggg
gcaatggctg tggcttgttt 1260ggaaaaggag gagttgtgac atgtgcgaag
ttttcatgtt cggggaagat aacaggcaat 1320ttggtccaaa ttgagaacct
tgaatacaca gtggttgtaa cagtccacaa tggagacacc 1380catgcagtag
gaaatgacac gtccaatcat ggagttacag ccacgataac tcccaggtca
1440ccatcggtgg aagtcaaatt gccggactat ggagaactaa cactcgattg
tgaacccagg 1500tctggaattg actttaatga gatgattctg atgaaaatga
aaaagaaaac atggcttgtg 1560cataagcaat ggtttttgga tctacctcta
ccatggacag caggagcaga cacatcagag 1620gttcactgga attacaaaga
gagaatggtg acatttaagg ttcctcatgc caagagacag 1680gatgtgacag
tgctgggatc tcaggaagga gccatgcatt ctgccctcgc tggagccaca
1740gaagtggact ccggtgatgg aaatcacatg tttgcaggac atctcaagtg
caaagtccgt 1800atggagaaat tgagaatcaa gggaatgtca tacacgatgt
gttcaggaaa gttctcaatt 1860gacaaagaga tggcagaaac acagcatggg
acaacagtgg tgaaagtcaa gtatgaaggt 1920gctggagctc cgtgtaaagt
ccccatagag ataagagatg tgaacaagga aaaagtggtt 1980gggcgtatca
tctcatccac ccctttggct gagaatacca acagtgtaac caacatagag
2040ttagaacccc cctttgggga cagctacata gtgataggtg ttggaaacag
tgcattaaca 2100ctccattggt tcaggaaagg gagttccatt ggcaagatgt
ttgagtccac atacagaggt 2160gcaaaacgaa tggccattct aggtgaaaca
gcttgggatt ttggttccgt tggtggactg 2220ttcacatcat tgggaaaggc
tgtgcaccag gtttttggaa gtgtgtatac aaccctgttt 2280ggaggagtct
catggatgat tagaatccta attgggttcc tagtgttgtg gattggcacg
2340aactcaagga acacttcaat ggctatgacg tgcatagctg ccggcattgt
gacactgtat 2400ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga
gctggaaaaa caaagaactg 2460aaatgtggca gtgggatttt catcacagac
aacgtgcaca catggacaga acaatacaag 2520ttccaaccag aatccccttc
aaaactagct tcagctatcc agaaagccca tgaagaggac 2580atttgtggaa
tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca
2640gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac
aggagacatc 2700aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc
agcccactga gctgaagtat 2760tcatggaaaa catggggcaa agcaaaaatg
ctctctacag agtctcataa ccagaccttt 2820ctcattgatg gccccgaaac
agcagaatgc cccaacacaa atagagcttg gaattcgttg 2880gaagttgaag
actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa
2940aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga
caacagagcc 3000gtccatgccg atatgggtta ttggatagaa agtgcactca
atgacacatg gaagatagag 3060aaagcctctt tcattgaagt taaaaactgc
cactggccaa aatcacacac cctctggagc 3120aatggagtgc tagaaagtga
gatgataatt ccaaagaatc tcgctggacc agtgtctcaa 3180cacaactata
gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt
3240gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga
ctgcggaaat 3300agaggaccct ctttgagaac aaccactgcc tctggaaaac
tcataacaga atggtgctgc 3360cgatcttgca cattaccacc gctaagatac
agaggtgagg atgggtgctg gtacgggatg 3420gaaatcagac cattgaagga
gaaagaagag aatttggtca actccttggt cacagctgga 3480catgggcagg
tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa
3540atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt
ttcttttgtg 3600acattgatca cagggaacat gtcctttaga gacctgggaa
gagtgatggt tatggtaggc 3660gccactatga cggatgacat aggtatgggc
gtgacttatc ttgccctact agcagccttc 3720aaagtcagac caacttttgc
agctggacta ctcttgagaa agctgacctc caaggaattg 3780atgatgacta
ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt
3840gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag
aaatatggaa 3900aagtatcaat tggcagtgac tatcatggct atcttgtgcg
tcccaaacgc agtgatatta 3960caaaacgcat ggaaagtgag ttgcacaata
ttggcagtgg tgtccgtttc cccactgttc 4020ttaacatcct cacagcaaaa
aacagattgg ataccattag cattgacgat caaaggtctc 4080aatccaacag
ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca
4140ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc
tctcctaaaa 4200aatgatattc ccatgacagg accattagtg gctggagggc
tcctcactgt gtgctacgtg 4260ctcactggac gatcggccga tttggaactg
gagagagcag ccgatgtcaa atgggaagac 4320caggcagaga tatcaggaag
cagtccaatc ctgtcaataa caatatcaga agatggtagc 4380atgtcgataa
aaaatgaaga ggaagaacaa acactgacca tactcattag aacaggattg
4440ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc
atggtacctg 4500tgggaagtga agaaacaacg ggccggagta ttgtgggatg
ttccttcacc cccacccatg 4560ggaaaggctg aactggaaga tggagcctat
agaattaagc aaaaagggat tcttggatat 4620tcccagatcg gagccggagt
ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca 4680cgtggcgctg
ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag
4740aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa
ggaaggagaa 4800gaagtccagg tattggcact ggagcctgga aaaaatccaa
gagccgtcca aacgaaacct 4860ggtcttttca aaaccaacgc cggaacaata
ggtgctgtat ctctggactt ttctcctgga 4920acgtcaggat ctccaattat
cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt 4980gttgttacaa
ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa
5040gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat
catggacctc 5100cacccaggag cgggaaagac gaagagatac cttccggcca
tagtcagaga agctataaaa 5160cggggtttga gaacattaat cttggccccc
actagagttg tggcagctga aatggaggaa 5220gcccttagag gacttccaat
aagataccag accccagcca tcagagctgt gcacaccggg 5280cgggagattg
tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt
5340agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga
cccagcaagt 5400atagcagcta gaggatacat ctcaactcga gtggagatgg
gtgaggcagc tgggattttt 5460atgacagcca ctcccccggg aagcagagac
ccatttcctc agagcaatgc accaatcata 5520gatgaagaaa gagaaatccc
tgaacgctcg tggaattccg gacatgaatg ggtcacggat 5580tttaaaggga
agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct
5640tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt
tgattctgag 5700tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta
caactgacat ttcagaaatg 5760ggtgccaatt tcaaggctga gagggttata
gaccccagac gctgcatgaa accagtcata 5820ctaacagatg gtgaagagcg
ggtgattctg gcaggaccta tgccagtgac ccactctagt 5880gcagcacaaa
gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata
5940tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga
agctaaaatg 6000ctcctagata acatcaacac gccagaagga atcattccta
gcatgttcga accagagcgt 6060gaaaaggtgg atgccattga tggcgaatac
cgcttgagag gagaagcaag gaaaaccttt 6120gtagacttaa tgagaagagg
agacctacca gtctggttgg cctacagagt ggcagctgaa 6180ggcatcaact
acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta
6240gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa
attgaaaccc 6300agatggttgg atgctaggat ctattctgac ccactggcgc
taaaagaatt taaggaattt 6360gcagccggaa gaaagtctct gaccctgaac
ctaatcacag aaatgggtag gctcccaacc 6420ttcttgactc agaaggcaag
agacgcactg gacaacttag cagtgctgca cacggctgag 6480gcaggtggaa
gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg
6540cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt
gatgagcgca 6600aggggcatag ggaagatgac cctgggaatg tgctgcataa
tcacggctag catcctccta 6660tggtacgcac aaatacagcc acactggata
gcagcttcaa taatactgga gttttttctc 6720atagttttgc ttattccaga
acctgaaaaa cagagaacac cccaagacaa ccaactgacc 6780tacgttgtca
tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc
6840ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca
acccgagagc 6900aacatcctgg acatagatct acgtcctgca tcagcatgga
cgctgtatgc cgtggccaca
6960acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa
tgtgtcccta 7020acagctatag ccaaccaagc cacagtgtta atgggtctcg
ggaaaggatg gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc
attggatgct actcacaagt caaccccata 7140actctcacag cagctctttt
cttattggta gcacattatg ccatcatagg gccaggactc 7200caagcaaaag
caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca
7260actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc
aaagtttgaa 7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga
ctcaagtatt gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc
ttagctaccg ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt
ttggaacact accattgcgg tgtcaatggc taacattttt 7500agagggagtt
acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac
7560acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa
aagccgattg 7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa
gtggaatcca ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga
ggagaaacgg accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg
gttcgttgag agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg
gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta
7860agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat
ccccatgtca 7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg
acgttttctt catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata
ggggagtcat caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt
ccttaactta gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa
aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta
8160caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc
cacacatgag 8220atgtactggg tatccaatgc ttccgggaac atagtgtcat
cagtgaacat gatttcaagg 8280atgttgatca acagatttac aatgagatac
aagaaagcca cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa
catcgggatt gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa
tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac
8460cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac
tggatcagca 8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac
cttgggacgt cgtccccatg 8580gtgacacaga tggcaatgac agacacgact
ccatttggac aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca
agaaccgaaa gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc
tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa
8760gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac
tgatgagaac 8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt
tttgggagct ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt
gaaacatgtg tgtacaacat gatgggaaaa 8940agagagaaga agctagggga
attcggcaag gcaaaaggca gcagagccat atggtacatg 9000tggcttggag
cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg
9060ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa
gctaggttac 9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt
atgccgatga caccgcagga 9180tgggatacaa gaatcacact agaagaccta
aaaaatgaag aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact
agccgaggcc attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc
aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac
9360caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa
tatggaagcc 9420caactaatca gacagatgga gggagaagga gtctttaaaa
gcattcagca cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta
gcaagagtgg ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga
ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc
taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca
9660agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca
tgagttaatc 9720atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc
aagatgaact gattggcaga 9780gcccgaatct cccaaggagc agggtggtct
ttgcgggaga cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt
gatgtacttc cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct
cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata
9960catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa
cagggtgtgg 10020attcaagaaa acccatggat ggaagacaaa actccagtgg
aatcatggga ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc
ggctcattga ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca
agcagcaata aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag
attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga
10260gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt
cggattaagc 10320catagtacgg aaaaaactat gctacctgtg agccccgtcc
aaggacgtta aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa
ctatgcagcc tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc
acaaaccatg gaagctgtac gcatggcgta gtggactagc 10500ggttagagga
gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga
10560agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa
caaaaaacag 10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc
tcagcatcat tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga
atcaacaggt tc 107221010699DNAArtificialSynthetic construct
10agttgttagt ctacgtggac cgacaagaac agtttcgact cggaagcttg cttaacgtag
60tgctgacagt tttttattag agagcagatc tctgatgaac aaccaacgga aaaagacggg
120aaaaccgtct atcaatatgc tgaaacgcgt gagaaaccgt gtgtcaactg
gatcacagtt 180ggcgaagaga ttctcaagag gattgctgaa cggccaagga
ccaatgaaat tggttatggc 240atttatagct ttcctcagat ttctagccat
tccaccgaca gcaggagtct tggctagatg 300gggtaccttt aagaagtcgg
gggctattaa ggtcttaaaa ggcttcaaga aggagatctc 360aaacatgctg
agcattatca acaaacggaa aaagacatcg ctctgtctca tgatgatgtt
420accagcaaca cttgctttcc acttaacttc acgagatgga gagccgcgca
tgattgtggg 480gaagaatgaa agaggaaaat ccctactttt caagacagcc
tctggaatca acatgtgcac 540actcatagcc atggatctgg gagagatgtg
tgatgacacg gtcacttaca aatgccccca 600cattaccgaa gtggagcctg
aagacattga ctgctggtgc aaccttacat cgacatgggt 660gacttatgga
acatgcaatc aagctggaga gcatagacgc gataagagat cagtggcgtt
720agctccccat gttggcatgg gactggacac acgcactcaa acctggatgt
cggctgaagg 780agcttggaga caagtcgaga aggtagagac atgggccctt
aggcacccag ggtttaccat 840actagcccta tttcttgccc attacatagg
cacttccttg acccagaaag tggttatttt 900tatactatta atgctggtta
ccccatccat gacaatgaga tgtgtaggag taggaaacag 960agattttgtg
gaaggcctat cgggagctac gtgggttgac gtggtgctcg agcacggtgg
1020gtgtgtgact accatggcta agaacaagcc cacgctggac atagagcttc
agaagaccga 1080ggccacccaa ctggcgaccc taaggaagct atgcattgag
ggaaaaatta ccaacataac 1140aaccgactca agatgtccca cccaagggga
agcgatttta cctgaggagc aggaccagaa 1200ctacgtgtgt aagcatacat
acgtggacag aggctgggga aacggttgtg gtttgtttgg 1260caagggaagc
ttggtgacat gcgcgaaatt tcaatgttta gaatcaatag agggaaaagt
1320ggtgcaacat gagaacctca aatacaccgt catcatcaca gtgcacacag
gagaccaaca 1380ccaggtggga aatgaaacgc agggagtcac ggctgagata
acaccccagg catcaaccgc 1440tgaagccatt ttacctgaat atggaaccct
cgggctagaa tgctcaccac ggacaggttt 1500ggatttcaat gaaatgatct
cattgacaat gaagaacaaa gcatggatgg tacatagaca 1560atggttcttt
gacttacccc taccatggac atcaggagct acagcagaaa caccaacttg
1620gaacaggaaa gagcttcttg tgacatttaa aaatgcacat gcaaaaaagc
aagaagtagt 1680tgttcttgga tcacaagagg gagcaatgca tacagcactg
acaggagcta cagagatcca 1740aacctcagga ggcacaagta tctttgcggg
gcacttaaaa tgtagactca agatggacaa 1800attggaactc aaggggatga
gctatgcaat gtgcttgagt agctttgtgt tgaagaaaga 1860agtctccgaa
acgcagcatg ggacaatact cattaaggtt gagtacaaag gggaagatgc
1920accctgcaag attcctttct ccacggagga tggacaagga aaagctcaca
atggcagact 1980gatcacagcc aatccagtgg tgaccaagaa ggaggagcct
gtcaacattg aggctgaacc 2040tccttttgga gaaagtaaca tagtaattgg
aattggagac aaagccctga aaatcaactg 2100gtacaagaag ggaagctcga
ttgggaagat gttcgaggcc actgccagag gtgcaaggcg 2160catggccatc
ttgggagaca cagcctggga ctttggatca gtgggtggtg ttttgaattc
2220attagggaaa atggtccacc aaatatttgg gagtgcttac acagccctat
ttggtggagt 2280ctcctggatg atgaaaattg gaataggtgt cctcttaacc
tggatagggt tgaactcaaa 2340aaatacttct atgtcatttt catgcatcgc
gataggaatc attacactct atctgggagc 2400cgtggtgcaa gctgacatgg
ggtgtgtcat aaactggaaa ggcaaagaac tcaaatgtgg 2460aagtggaatt
ttcgtcacta atgaggtcca cacctggaca gagcaataca aatttcaagc
2520agactccccc aagagactgg caacagccat tgcaggcgct tgggaaaatg
gagtgtgcgg 2580aattaggtca acaaccagaa tggagaacct cttgtggaag
caaatagcca atgaactgaa 2640ttacatatta tgggaaaaca acattaaatt
aacggtagtt gtaggcgaca taactggggt 2700cttagagcaa gggaaaagaa
cactaacacc acaacccatg gagctaaaat attcttggaa 2760aacatgggga
aaggcaaaaa tagtgacagc tgaaacacaa aattcctctt tcataataga
2820tgggccaagc acaccggagt gtccaagtgc ctcaagagca tggaatgtgt
gggaggtgga 2880ggattacggg ttcggagttt tcacaaccaa catatggctg
aaactccgag aggtgtacac 2940ccaactatgt gaccataggc taatgtcggc
agccgtcaag gatgagaggg ctgtacatgc 3000cgacatgggc tattggatag
aaagccaaaa gaatgggagt tggaagctag aaaaagcatc 3060cttcatagag
gtgaaaacct gcacatggcc aaaatcacac actctctgga gcaatggtgt
3120gctagagagt gacatgatta tcccaaagag tctagctggt cccatttcgc
aacacaacca 3180caggcccggg taccacaccc aaacggcagg accctggcac
ttaggaaaat tggagctgga 3240cttcaactat tgtgaaggaa caacagttgt
catctcagaa aactgtggga caagaggccc 3300atcattgaga acaacaacgg
tgtcagggaa gttgatacac gaatggtgct gccgctcgtg 3360cacacttcct
cccctacgat acatgggaga agacggctgc tggtatggca tggaaatcag
3420acccattaat gagaaagaag agaatatggt aaagtctcta gcctcagcag
ggagtggaaa 3480ggtggacaac ttcacaatgg gtgtcttgtg tttggcaatc
ctctttgaag aggtgatgag 3540aggaaaattt gggaaaaaac acatgattgc
aggggttctc ttcacgtttg tgctcctcct 3600ctcagggcaa ataacatgga
gagacatggc gcacacactc ataatgattg ggtccaacgc 3660ctctgacaga
atggggatgg gcgtcactta cctagctcta attgcaacat ttaaaattca
3720gccattcctg gctttgggat tcttcctgag gaaactgaca tctagagaaa
atttattgct 3780gggagttggg ttggccatgg cagcaacgtt acgactgcca
gaggacattg aacagatggc 3840gaatggaatt gctttggggc tcatggctct
taaactgata acacaatttg aaacatacca 3900actatggacg gcattagttt
ccctaacgtg ttcaaataca attttcacgt tgactgttgc 3960ctggagaaca
gccactctga ttttagccgg aatttcgctt ttgccagtgt gccagtcttc
4020gagcatgagg aaaacagatt ggctcccaat gactgtggca gctatgggag
ctcaacccct 4080accacttttt attttcagtc tgaaagatac actcaaaagg
agaagctggc cactgaatga 4140gggggtgatg gcagttggac ttgtgagcat
tctagctagt tctctcctta ggaatgatgt 4200gcctatggct ggaccattag
tggctggggg cttgctgata gcgtgctacg tcataactgg 4260cacgtcagca
gacctcactg tagaaaaagc agcagatgta acatgggagg aagaggccga
4320gcaaacagga gtgtcccaca atttaatggt cacagttgat gatgatggaa
caatgagaat 4380aaaagatgac gagactgaga acatcttaac agtgctttta
aaaacagcac tactaatagt 4440atcaggcatc tttccatact ccatacccgc
aacactgttg gtctggcata cttggcaaaa 4500gcaaacccaa agatccggcg
tcctatggga cgtacccagc cccccagaga cacagaaagc 4560ggaactggaa
gaaggggtct ataggatcaa acagcaagga atttttggga aaacccaagt
4620gggggttgga gtacagaaag aaggagtttt ccacaccatg tggcatgtca
caagaggggc 4680agtgttgaca cacaatggga aaagactgga accaaactgg
gctagcgtga aaaaagatct 4740gatttcatac ggaggaggat ggagattgag
tgcacaatgg caaaaggggg aggaggtgca 4800ggttattgcc gtagagcctg
ggaagaaccc aaagaacttt caaaccatgc caggcatttt 4860tcagacaaca
acaggggaaa taggagcaat tgcactggat ttcaagcctg gaacttcagg
4920atctcccatc ataaacagag agggaaaggt agtgggactg tatggcaatg
gagtggttac 4980aaagaatgga ggctatgtca gtggaatagc gcaaacaaat
gcagaaccag atggaccgac 5040accagagttg gaagaagaga tgttcaaaaa
gcgaaatcta accataatgg atctccatcc 5100tgggtcagga aagacgcgga
aatatcttcc agctattgtt agagaggcaa tcaagagacg 5160cttaaggact
ctaattttgg caccaacaag ggtagttgca gctgagatgg aagaagcatt
5220gaaagggctc ccaataaggt atcaaacaac tgcaacaaaa tctgaacaca
caggaagaga 5280gattgttgat ctaatgtgtc acgcaacgtt cacaatgcgc
ttgctgtcac cagtcagggt 5340tccaaactac aacttgataa taatggatga
ggcccatttc acagacccag ccagtatagc 5400ggctagaggg tacatatcaa
ctcgtgtagg aatgggagag gcagccgcaa ttttcatgac 5460agcaacaccc
cctggaacag ctgatgcctt tcctcagagc aacgctccaa ttcaagatga
5520agagagagac ataccggaac gctcatggaa ttcaggcaat gaatggatta
ctgactttgt 5580tgggaagaca gtgtggtttg tccctagcat caaagccgga
aatgacatag caaactgctt 5640gcggaaaaat ggaaaaaagg ttattcaact
cagcaggaag acctttgaca cagaatatca 5700aaagaccaaa ctgaatgatt
gggactttgt ggtgacaaca gacatttcag aaatgggagc 5760caatttcaaa
gcagatagag tgatcgaccc aagaagatgt ctcaagccgg tgattttgac
5820agatggaccc gagcgggtga tcctggctgg accaatgcca gtcaccgtag
cgagcgctgc 5880gcaaaggaga gggagagttg gcaggaaccc acaaaaagaa
aatgaccagt acatattcat 5940gggccagcct ctcaacaatg atgaagacca
tgctcactgg acagaagcaa aaatgctgct 6000ggacaacatc aacacaccag
aagggattat accagctctc tttgaaccag aaagggagaa 6060gtcagccgcc
atagacggcg aataccgcct gaagggtgag tccaggaaga ctttcgtgga
6120actcatgagg aggggtgacc tcccagtttg gctagcccat aaagtagcat
cagaagggat 6180caaatataca gatagaaaat ggtgctttga tggagaacgt
aataatcaaa ttttagagga 6240gaatatggat gtggaaatct ggacaaagga
aggagaaaag aaaaaactga gacctaggtg 6300gcttgatgcc cgcacttatt
cagatccttt agcactcaaa gaattcaagg attttgcagc 6360tggcagaaag
tcaatcgccc ttgatcttgt gacagaaata ggaagagtgc cttcacactt
6420agcccacaga acgagaaacg ccctggataa tttggtgatg ctgcacacgt
cagaacatgg 6480cggtagggcc tacaggcatg cagtggagga actaccagaa
acgatggaaa cactcttact 6540cctgggactg atgatcttgt taacaggtgg
agcaatgctc ttcttgatat caggtaaagg 6600gattggaaag acttcaatag
gactcatttg tgtaattgct tccagcggca tgttatggat 6660ggctgatgtc
ccactccaat ggatcgcatc ggctatagtc ctggagtttt ttatgatggt
6720gttgctcata ccagaaccag aaaagcagag aactccccaa gacaaccaac
tcgcatatgt 6780cgtgataggc atacttacat tggctgcaat agtagcggcc
aatgaaatgg gactgttgga 6840aactacaaag agagatttag gaatgtctaa
agaaccaggt gttgtttctc caaccagcta 6900tttggatgtg gacttgcacc
cagcatcagc ctggacattg tacgccgtgg ccacaacagt 6960aataacacca
atgttgagac acaccataga gaattccaca gcaaatgtgt ctctggcagc
7020catagctaac caggcagtgg tcctgatggg tttagacaaa ggatggccga
tatcgaaaat 7080ggacttgggc gtaccactat tggcactggg ttgctattca
caagtgaacc cactaactct 7140tgcagcggca gtacttttgc tagtcacaca
ttatgcaatt ataggtccag gattgcaggc 7200aaaagccacc cgtgaagctc
agaaaaggac agctgctgga ataatgaaga atccaacggt 7260ggatggaata
atgacaatag acctagatcc tgtaatatat gattcaaaat ttgaaaagca
7320actaggacag gtcatgctcc tggttctgtg tgcagtccaa cttttattga
tgagaacatc 7380atgggccttg tgtgaagttc taaccctagc cacaggacca
ataacaacac tctgggaagg 7440atcacctggg aagttctgga acaccacgat
agctgtttcc atggcgaaca tctttagagg 7500gagctattta gcaggagctg
ggcttgcttt ttctatcatg aaatcagttg gaacaggaaa 7560gagaggaaca
gggtcacaag gtgaaacctt aggagaaaag tggaaaaaga aattaaatca
7620gttatcccgg aaagagtttg acctttacaa gaaatccgga atcaccgaag
tggatagaac 7680agaagccaaa gaagggttaa aaagaggaga aataacacac
catgccgtgt ccagaggcag 7740cgcaaaactt caatggttcg tggagagaaa
catggtcatt cctgaaggaa gagtcataga 7800cctaggctgt ggaagaggag
gctggtcata ttactgtgca ggactgaaaa aagttacaga 7860agtgcgagga
tacacaaaag gcggcccagg acacgaagaa ccagtaccta tgtctacata
7920cggatggaac atagtcaagt taatgagtgg aaaggatgtt ttttatctgc
cacctgaaaa 7980gtgtgatacc ctattgtgtg acattggaga atcttcacca
agcccaacag tggaagaaag 8040cagaaccata agagttttga agatggttga
accatggcta aagaacaacc agttttgcat 8100taaagtattg aacccataca
tgccaactgt gattgagcac ttagaaagac tacaaaggaa 8160acatggagga
atgcttgtga gaaatccact ctcacgaaac tccacgcacg aaatgtattg
8220gatatccaat ggtacaggca atatcgtctc ttcagtcaac atggtatcca
gattgctact 8280gaacagattc acaatgacac acaggagacc caccatagag
aaagatgtgg atctaggagc 8340aggaacccga catgtcaatg cggaaccaga
aacacccaac atggatgtca ttggggaaag 8400aataaaaagg atcaaagagg
agcatagttc aacatggcac tatgatgatg aaaatcctta 8460caaaacgtgg
gcttaccatg gatcctatga agtaaaagcc acaggctcag cctcctccat
8520gataaatgga gtcgtgaaac tcctcacaaa accatgggat gtggtgccca
tggtgacaca 8580gatggcaatg acagatacaa ctccattcgg ccagcaaaga
gtttttaaag agaaagtgga 8640caccaggaca cctaggccca tgccaggaac
aagaaaggtt atggagatca cagcggagtg 8700gctttggagg accctgggaa
ggaacaaaag acccagatta tgcacaaggg aggaattcac 8760aaagaaggtc
agaaccaacg cagctatggg cgctgtcttc acagaagaga accaatggga
8820cagtgcgaga gctgctgttg aggacgaaga attttggaaa cttgtggaca
gagaacgtga 8880actccacaaa ctgggcaagt gtggaagctg cgtttacaac
atgatgggca agagagagaa 8940aaaacttgga gagtttggta aagcaaaagg
cagtagggct atatggtaca tgtggttggg 9000agccaggtac cttgagttcg
aggcgctcgg attcctcaat gaagaccact ggttctcgcg 9060tgaaaactct
tacagtggag tagaaggaga aggactgcac aagctgggat acatcttgag
9120agatatttcc aagatacccg gaggagccat gtatgctgat gacacagccg
gttgggacac 9180aagaataaca gaagatgacc tgcacaatga ggaaaaaatc
acacagcaga tggaccctga 9240acacaggcag ctagcgaacg ctatattcaa
gctcacatac caaaacaaag tggtcaaagt 9300ccaacgacca actccaaagg
gcacggtaat ggacatcata tctaggaaag accaaagagg 9360cagtggacag
gtgggaactt atggtctgaa cacattcacc aacatggaag cccagctaat
9420cagacaaatg gaaggagaag gcgtgttgtc aaaggcagac ctcgagaacc
cccatccgct 9480agagaagaaa attacacaat ggttggaaac taaaggagtg
gaaaggttaa aaagaatggc 9540catcagcggg gatgattgcg ttgtgaaacc
aatcgacgac agattcgcca atgccctgct 9600tgccctgaac gatatgggaa
aggttagaaa ggacatacct caatggcagc catcaaaggg 9660atggcatgat
tggcaacagg tccccttctg ctcccaccac tttcatgaat tgatcatgaa
9720agatggaaga aagttggtag ttccctgcag accccaggac gaactaatag
gaagagcgag 9780aatctcccaa ggagcaggat ggagccttag agaaactgca
tgtctaggga aagcctacgc 9840tcaaatgtgg gctctcatgt attttcacag
aagagatctt agactagcat ccaacgccat 9900atgttcagca gtaccagtcc
actgggtccc cacgagcaga acgacatggt ctattcatgc 9960tcaccatcag
tggatgacta cagaagacat gcttactgtc tggaacaggg tgtggataga
10020ggacaatcca tggatggaag acaaaactcc agtcacaacg tgggaagatg
ttccatatct 10080agggaagaga gaagaccaat ggtgcggatc actcataggt
ctcacttcca gagcaacctg 10140ggcccagaac atactcacag caatccaaca
ggtgagaagc ctcataggca atgaagagtt 10200tctggactac atgccttcga
tgaagagatt caggaaggag gaggagtcag agggagccat 10260ttggtaaaag
caggaggtaa actgtcaggc cacattaagc cacagtacgg aagaagctgt
10320gcagcctgtg agccccgtcc aaggacgtta aaagaagaag tcaggcccaa
aagccacggt 10380ttgagcaaac cgtgctgcct gtagctccgt cgtggggacg
taaagcctgg gaggctgcaa 10440accgtggaag ctgtacgcac ggtgtagcag
actagtggtt agaggagacc cctcccatga 10500cacaacgcag cagcggggcc
cgagcactga gggaagctgt acctccttgc aaaggactag 10560aggttagagg
agaccccccg caaacaaaaa cagcatattg acgctgggag agaccagaga
10620tcctgctgtc tcctcagcat cattccaggc acagaacgcc agaaaatgga
atggtgctgt 10680tgaatcaaca ggttctagt
10699113390PRTArtificialSynthetic construct 11Met Asn Asn Gln Arg
Lys Lys Thr Gly Lys Pro Ser Ile Asn Met Leu 1 5 10 15 Lys Arg Val
Arg Asn Arg Val Ser Thr Gly Ser Gln Leu Ala Lys Arg 20 25 30 Phe
Ser Arg Gly Leu Leu Asn Gly Gln Gly Pro Met Lys Leu Val Met 35 40
45 Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly
50 55 60 Val Leu Ala Arg Trp Gly
Thr Phe Lys Lys Ser Gly Ala Ile Lys Val 65 70 75 80 Leu Lys Gly Phe
Lys Lys Glu Ile Ser Asn Met Leu Ser Ile Ile Asn 85 90 95 Lys Arg
Lys Lys Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala Thr 100 105 110
Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile Val 115
120 125 Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser
Gly 130 135 140 Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu
Met Cys Asp 145 150 155 160 Asp Thr Val Thr Tyr Lys Cys Pro His Ile
Thr Glu Val Glu Pro Glu 165 170 175 Asp Ile Asp Cys Trp Cys Asn Leu
Thr Ser Thr Trp Val Thr Tyr Gly 180 185 190 Thr Cys Asn Gln Ala Gly
Glu His Arg Arg Asp Lys Arg Ser Val Ala 195 200 205 Leu Ala Pro His
Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp 210 215 220 Met Ser
Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp 225 230 235
240 Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His
245 250 255 Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile
Leu Leu 260 265 270 Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val
Gly Val Gly Asn 275 280 285 Arg Asp Phe Val Glu Gly Leu Ser Gly Ala
Thr Trp Val Asp Val Val 290 295 300 Leu Glu His Gly Gly Cys Val Thr
Thr Met Ala Lys Asn Lys Pro Thr 305 310 315 320 Leu Asp Ile Glu Leu
Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu 325 330 335 Arg Lys Leu
Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser 340 345 350 Arg
Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln 355 360
365 Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly
370 375 380 Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys
Phe Gln 385 390 395 400 Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln
His Glu Asn Leu Lys 405 410 415 Tyr Thr Val Ile Ile Thr Val His Thr
Gly Asp Gln His Gln Val Gly 420 425 430 Asn Glu Thr Gln Gly Val Thr
Ala Glu Ile Thr Pro Gln Ala Ser Thr 435 440 445 Ala Glu Ala Ile Leu
Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser 450 455 460 Pro Arg Thr
Gly Leu Asp Phe Asn Glu Met Ile Ser Leu Thr Met Lys 465 470 475 480
Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu 485
490 495 Pro Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro Thr Trp Asn Arg
Lys 500 505 510 Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys
Gln Glu Val 515 520 525 Val Val Leu Gly Ser Gln Glu Gly Ala Met His
Thr Ala Leu Thr Gly 530 535 540 Ala Thr Glu Ile Gln Thr Ser Gly Gly
Thr Ser Ile Phe Ala Gly His 545 550 555 560 Leu Lys Cys Arg Leu Lys
Met Asp Lys Leu Glu Leu Lys Gly Met Ser 565 570 575 Tyr Ala Met Cys
Leu Ser Ser Phe Val Leu Lys Lys Glu Val Ser Glu 580 585 590 Thr Gln
His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp 595 600 605
Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala 610
615 620 His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys
Glu 625 630 635 640 Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly
Glu Ser Asn Ile 645 650 655 Val Ile Gly Ile Gly Asp Lys Ala Leu Lys
Ile Asn Trp Tyr Lys Lys 660 665 670 Gly Ser Ser Ile Gly Lys Met Phe
Glu Ala Thr Ala Arg Gly Ala Arg 675 680 685 Arg Met Ala Ile Leu Gly
Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 690 695 700 Gly Val Leu Asn
Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser 705 710 715 720 Ala
Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly 725 730
735 Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser
740 745 750 Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr
Leu Gly 755 760 765 Ala Val Val Gln Ala Asp Met Gly Cys Val Ile Asn
Trp Lys Gly Lys 770 775 780 Glu Leu Lys Cys Gly Ser Gly Ile Phe Val
Thr Asn Glu Val His Thr 785 790 795 800 Trp Thr Glu Gln Tyr Lys Phe
Gln Ala Asp Ser Pro Lys Arg Leu Ala 805 810 815 Thr Ala Ile Ala Gly
Ala Trp Glu Asn Gly Val Cys Gly Ile Arg Ser 820 825 830 Thr Thr Arg
Met Glu Asn Leu Leu Trp Lys Gln Ile Ala Asn Glu Leu 835 840 845 Asn
Tyr Ile Leu Trp Glu Asn Asn Ile Lys Leu Thr Val Val Val Gly 850 855
860 Asp Ile Thr Gly Val Leu Glu Gln Gly Lys Arg Thr Leu Thr Pro Gln
865 870 875 880 Pro Met Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys
Ala Lys Ile 885 890 895 Val Thr Ala Glu Thr Gln Asn Ser Ser Phe Ile
Ile Asp Gly Pro Ser 900 905 910 Thr Pro Glu Cys Pro Ser Ala Ser Arg
Ala Trp Asn Val Trp Glu Val 915 920 925 Glu Asp Tyr Gly Phe Gly Val
Phe Thr Thr Asn Ile Trp Leu Lys Leu 930 935 940 Arg Glu Val Tyr Thr
Gln Leu Cys Asp His Arg Leu Met Ser Ala Ala 945 950 955 960 Val Lys
Asp Glu Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 965 970 975
Ser Gln Lys Asn Gly Ser Trp Lys Leu Glu Lys Ala Ser Phe Ile Glu 980
985 990 Val Lys Thr Cys Thr Trp Pro Lys Ser His Thr Leu Trp Ser Asn
Gly 995 1000 1005 Val Leu Glu Ser Asp Met Ile Ile Pro Lys Ser Leu
Ala Gly Pro 1010 1015 1020 Ile Ser Gln His Asn His Arg Pro Gly Tyr
His Thr Gln Thr Ala 1025 1030 1035 Gly Pro Trp His Leu Gly Lys Leu
Glu Leu Asp Phe Asn Tyr Cys 1040 1045 1050 Glu Gly Thr Thr Val Val
Ile Ser Glu Asn Cys Gly Thr Arg Gly 1055 1060 1065 Pro Ser Leu Arg
Thr Thr Thr Val Ser Gly Lys Leu Ile His Glu 1070 1075 1080 Trp Cys
Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg Tyr Met Gly 1085 1090 1095
Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Ile Asn Glu 1100
1105 1110 Lys Glu Glu Asn Met Val Lys Ser Leu Ala Ser Ala Gly Ser
Gly 1115 1120 1125 Lys Val Asp Asn Phe Thr Met Gly Val Leu Cys Leu
Ala Ile Leu 1130 1135 1140 Phe Glu Glu Val Met Arg Gly Lys Phe Gly
Lys Lys His Met Ile 1145 1150 1155 Ala Gly Val Leu Phe Thr Phe Val
Leu Leu Leu Ser Gly Gln Ile 1160 1165 1170 Thr Trp Arg Asp Met Ala
His Thr Leu Ile Met Ile Gly Ser Asn 1175 1180 1185 Ala Ser Asp Arg
Met Gly Met Gly Val Thr Tyr Leu Ala Leu Ile 1190 1195 1200 Ala Thr
Phe Lys Ile Gln Pro Phe Leu Ala Leu Gly Phe Phe Leu 1205 1210 1215
Arg Lys Leu Thr Ser Arg Glu Asn Leu Leu Leu Gly Val Gly Leu 1220
1225 1230 Ala Met Ala Ala Thr Leu Arg Leu Pro Glu Asp Ile Glu Gln
Met 1235 1240 1245 Ala Asn Gly Ile Ala Leu Gly Leu Met Ala Leu Lys
Leu Ile Thr 1250 1255 1260 Gln Phe Glu Thr Tyr Gln Leu Trp Thr Ala
Leu Val Ser Leu Thr 1265 1270 1275 Cys Ser Asn Thr Ile Phe Thr Leu
Thr Val Ala Trp Arg Thr Ala 1280 1285 1290 Thr Leu Ile Leu Ala Gly
Ile Ser Leu Leu Pro Val Cys Gln Ser 1295 1300 1305 Ser Ser Met Arg
Lys Thr Asp Trp Leu Pro Met Thr Val Ala Ala 1310 1315 1320 Met Gly
Ala Gln Pro Leu Pro Leu Phe Ile Phe Ser Leu Lys Asp 1325 1330 1335
Thr Leu Lys Arg Arg Ser Trp Pro Leu Asn Glu Gly Val Met Ala 1340
1345 1350 Val Gly Leu Val Ser Ile Leu Ala Ser Ser Leu Leu Arg Asn
Asp 1355 1360 1365 Val Pro Met Ala Gly Pro Leu Val Ala Gly Gly Leu
Leu Ile Ala 1370 1375 1380 Cys Tyr Val Ile Thr Gly Thr Ser Ala Asp
Leu Thr Val Glu Lys 1385 1390 1395 Ala Ala Asp Val Thr Trp Glu Glu
Glu Ala Glu Gln Thr Gly Val 1400 1405 1410 Ser His Asn Leu Met Val
Thr Val Asp Asp Asp Gly Thr Met Arg 1415 1420 1425 Ile Lys Asp Asp
Glu Thr Glu Asn Ile Leu Thr Val Leu Leu Lys 1430 1435 1440 Thr Ala
Leu Leu Ile Val Ser Gly Ile Phe Pro Tyr Ser Ile Pro 1445 1450 1455
Ala Thr Leu Leu Val Trp His Thr Trp Gln Lys Gln Thr Gln Arg 1460
1465 1470 Ser Gly Val Leu Trp Asp Val Pro Ser Pro Pro Glu Thr Gln
Lys 1475 1480 1485 Ala Glu Leu Glu Glu Gly Val Tyr Arg Ile Lys Gln
Gln Gly Ile 1490 1495 1500 Phe Gly Lys Thr Gln Val Gly Val Gly Val
Gln Lys Glu Gly Val 1505 1510 1515 Phe His Thr Met Trp His Val Thr
Arg Gly Ala Val Leu Thr His 1520 1525 1530 Asn Gly Lys Arg Leu Glu
Pro Asn Trp Ala Ser Val Lys Lys Asp 1535 1540 1545 Leu Ile Ser Tyr
Gly Gly Gly Trp Arg Leu Ser Ala Gln Trp Gln 1550 1555 1560 Lys Gly
Glu Glu Val Gln Val Ile Ala Val Glu Pro Gly Lys Asn 1565 1570 1575
Pro Lys Asn Phe Gln Thr Met Pro Gly Ile Phe Gln Thr Thr Thr 1580
1585 1590 Gly Glu Ile Gly Ala Ile Ala Leu Asp Phe Lys Pro Gly Thr
Ser 1595 1600 1605 Gly Ser Pro Ile Ile Asn Arg Glu Gly Lys Val Val
Gly Leu Tyr 1610 1615 1620 Gly Asn Gly Val Val Thr Lys Asn Gly Gly
Tyr Val Ser Gly Ile 1625 1630 1635 Ala Gln Thr Asn Ala Glu Pro Asp
Gly Pro Thr Pro Glu Leu Glu 1640 1645 1650 Glu Glu Met Phe Lys Lys
Arg Asn Leu Thr Ile Met Asp Leu His 1655 1660 1665 Pro Gly Ser Gly
Lys Thr Arg Lys Tyr Leu Pro Ala Ile Val Arg 1670 1675 1680 Glu Ala
Ile Lys Arg Arg Leu Arg Thr Leu Ile Leu Ala Pro Thr 1685 1690 1695
Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Lys Gly Leu Pro 1700
1705 1710 Ile Arg Tyr Gln Thr Thr Ala Thr Lys Ser Glu His Thr Gly
Arg 1715 1720 1725 Glu Ile Val Asp Leu Met Cys His Ala Thr Phe Thr
Met Arg Leu 1730 1735 1740 Leu Ser Pro Val Arg Val Pro Asn Tyr Asn
Leu Ile Ile Met Asp 1745 1750 1755 Glu Ala His Phe Thr Asp Pro Ala
Ser Ile Ala Ala Arg Gly Tyr 1760 1765 1770 Ile Ser Thr Arg Val Gly
Met Gly Glu Ala Ala Ala Ile Phe Met 1775 1780 1785 Thr Ala Thr Pro
Pro Gly Thr Ala Asp Ala Phe Pro Gln Ser Asn 1790 1795 1800 Ala Pro
Ile Gln Asp Glu Glu Arg Asp Ile Pro Glu Arg Ser Trp 1805 1810 1815
Asn Ser Gly Asn Glu Trp Ile Thr Asp Phe Val Gly Lys Thr Val 1820
1825 1830 Trp Phe Val Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala Asn
Cys 1835 1840 1845 Leu Arg Lys Asn Gly Lys Lys Val Ile Gln Leu Ser
Arg Lys Thr 1850 1855 1860 Phe Asp Thr Glu Tyr Gln Lys Thr Lys Leu
Asn Asp Trp Asp Phe 1865 1870 1875 Val Val Thr Thr Asp Ile Ser Glu
Met Gly Ala Asn Phe Lys Ala 1880 1885 1890 Asp Arg Val Ile Asp Pro
Arg Arg Cys Leu Lys Pro Val Ile Leu 1895 1900 1905 Thr Asp Gly Pro
Glu Arg Val Ile Leu Ala Gly Pro Met Pro Val 1910 1915 1920 Thr Val
Ala Ser Ala Ala Gln Arg Arg Gly Arg Val Gly Arg Asn 1925 1930 1935
Pro Gln Lys Glu Asn Asp Gln Tyr Ile Phe Met Gly Gln Pro Leu 1940
1945 1950 Asn Asn Asp Glu Asp His Ala His Trp Thr Glu Ala Lys Met
Leu 1955 1960 1965 Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile Pro
Ala Leu Phe 1970 1975 1980 Glu Pro Glu Arg Glu Lys Ser Ala Ala Ile
Asp Gly Glu Tyr Arg 1985 1990 1995 Leu Lys Gly Glu Ser Arg Lys Thr
Phe Val Glu Leu Met Arg Arg 2000 2005 2010 Gly Asp Leu Pro Val Trp
Leu Ala His Lys Val Ala Ser Glu Gly 2015 2020 2025 Ile Lys Tyr Thr
Asp Arg Lys Trp Cys Phe Asp Gly Glu Arg Asn 2030 2035 2040 Asn Gln
Ile Leu Glu Glu Asn Met Asp Val Glu Ile Trp Thr Lys 2045 2050 2055
Glu Gly Glu Lys Lys Lys Leu Arg Pro Arg Trp Leu Asp Ala Arg 2060
2065 2070 Thr Tyr Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Asp Phe
Ala 2075 2080 2085 Ala Gly Arg Lys Ser Ile Ala Leu Asp Leu Val Thr
Glu Ile Gly 2090 2095 2100 Arg Val Pro Ser His Leu Ala His Arg Thr
Arg Asn Ala Leu Asp 2105 2110 2115 Asn Leu Val Met Leu His Thr Ser
Glu His Gly Gly Arg Ala Tyr 2120 2125 2130 Arg His Ala Val Glu Glu
Leu Pro Glu Thr Met Glu Thr Leu Leu 2135 2140 2145 Leu Leu Gly Leu
Met Ile Leu Leu Thr Gly Gly Ala Met Leu Phe 2150 2155 2160 Leu Ile
Ser Gly Lys Gly Ile Gly Lys Thr Ser Ile Gly Leu Ile 2165 2170 2175
Cys Val Ile Ala Ser Ser Gly Met Leu Trp Met Ala Asp Val Pro 2180
2185 2190 Leu Gln Trp Ile Ala Ser Ala Ile Val Leu Glu Phe Phe Met
Met 2195 2200 2205 Val Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg Thr
Pro Gln Asp 2210 2215 2220 Asn Gln Leu Ala Tyr Val Val Ile Gly Ile
Leu Thr Leu Ala Ala 2225 2230 2235 Ile Val Ala Ala Asn Glu Met Gly
Leu Leu Glu Thr Thr Lys Arg 2240 2245 2250 Asp Leu Gly Met Ser Lys
Glu Pro Gly Val Val Ser Pro Thr Ser 2255 2260 2265 Tyr Leu Asp Val
Asp Leu His Pro Ala Ser Ala Trp Thr Leu Tyr 2270 2275 2280 Ala Val
Ala Thr Thr Val Ile Thr Pro Met Leu Arg His Thr Ile 2285 2290 2295
Glu Asn Ser Thr Ala Asn Val Ser Leu Ala Ala Ile Ala Asn Gln
2300
2305 2310 Ala Val Val Leu Met Gly Leu Asp Lys Gly Trp Pro Ile Ser
Lys 2315 2320 2325 Met Asp Leu Gly Val Pro Leu Leu Ala Leu Gly Cys
Tyr Ser Gln 2330 2335 2340 Val Asn Pro Leu Thr Leu Ala Ala Ala Val
Leu Leu Leu Val Thr 2345 2350 2355 His Tyr Ala Ile Ile Gly Pro Gly
Leu Gln Ala Lys Ala Thr Arg 2360 2365 2370 Glu Ala Gln Lys Arg Thr
Ala Ala Gly Ile Met Lys Asn Pro Thr 2375 2380 2385 Val Asp Gly Ile
Met Thr Ile Asp Leu Asp Pro Val Ile Tyr Asp 2390 2395 2400 Ser Lys
Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val Leu 2405 2410 2415
Cys Ala Val Gln Leu Leu Leu Met Arg Thr Ser Trp Ala Leu Cys 2420
2425 2430 Glu Val Leu Thr Leu Ala Thr Gly Pro Ile Thr Thr Leu Trp
Glu 2435 2440 2445 Gly Ser Pro Gly Lys Phe Trp Asn Thr Thr Ile Ala
Val Ser Met 2450 2455 2460 Ala Asn Ile Phe Arg Gly Ser Tyr Leu Ala
Gly Ala Gly Leu Ala 2465 2470 2475 Phe Ser Ile Met Lys Ser Val Gly
Thr Gly Lys Arg Gly Thr Gly 2480 2485 2490 Ser Gln Gly Glu Thr Leu
Gly Glu Lys Trp Lys Lys Lys Leu Asn 2495 2500 2505 Gln Leu Ser Arg
Lys Glu Phe Asp Leu Tyr Lys Lys Ser Gly Ile 2510 2515 2520 Thr Glu
Val Asp Arg Thr Glu Ala Lys Glu Gly Leu Lys Arg Gly 2525 2530 2535
Glu Ile Thr His His Ala Val Ser Arg Gly Ser Ala Lys Leu Gln 2540
2545 2550 Trp Phe Val Glu Arg Asn Met Val Ile Pro Glu Gly Arg Val
Ile 2555 2560 2565 Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr
Cys Ala Gly 2570 2575 2580 Leu Lys Lys Val Thr Glu Val Arg Gly Tyr
Thr Lys Gly Gly Pro 2585 2590 2595 Gly His Glu Glu Pro Val Pro Met
Ser Thr Tyr Gly Trp Asn Ile 2600 2605 2610 Val Lys Leu Met Ser Gly
Lys Asp Val Phe Tyr Leu Pro Pro Glu 2615 2620 2625 Lys Cys Asp Thr
Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro Ser 2630 2635 2640 Pro Thr
Val Glu Glu Ser Arg Thr Ile Arg Val Leu Lys Met Val 2645 2650 2655
Glu Pro Trp Leu Lys Asn Asn Gln Phe Cys Ile Lys Val Leu Asn 2660
2665 2670 Pro Tyr Met Pro Thr Val Ile Glu His Leu Glu Arg Leu Gln
Arg 2675 2680 2685 Lys His Gly Gly Met Leu Val Arg Asn Pro Leu Ser
Arg Asn Ser 2690 2695 2700 Thr His Glu Met Tyr Trp Ile Ser Asn Gly
Thr Gly Asn Ile Val 2705 2710 2715 Ser Ser Val Asn Met Val Ser Arg
Leu Leu Leu Asn Arg Phe Thr 2720 2725 2730 Met Thr His Arg Arg Pro
Thr Ile Glu Lys Asp Val Asp Leu Gly 2735 2740 2745 Ala Gly Thr Arg
His Val Asn Ala Glu Pro Glu Thr Pro Asn Met 2750 2755 2760 Asp Val
Ile Gly Glu Arg Ile Lys Arg Ile Lys Glu Glu His Ser 2765 2770 2775
Ser Thr Trp His Tyr Asp Asp Glu Asn Pro Tyr Lys Thr Trp Ala 2780
2785 2790 Tyr His Gly Ser Tyr Glu Val Lys Ala Thr Gly Ser Ala Ser
Ser 2795 2800 2805 Met Ile Asn Gly Val Val Lys Leu Leu Thr Lys Pro
Trp Asp Val 2810 2815 2820 Val Pro Met Val Thr Gln Met Ala Met Thr
Asp Thr Thr Pro Phe 2825 2830 2835 Gly Gln Gln Arg Val Phe Lys Glu
Lys Val Asp Thr Arg Thr Pro 2840 2845 2850 Arg Pro Met Pro Gly Thr
Arg Lys Val Met Glu Ile Thr Ala Glu 2855 2860 2865 Trp Leu Trp Arg
Thr Leu Gly Arg Asn Lys Arg Pro Arg Leu Cys 2870 2875 2880 Thr Arg
Glu Glu Phe Thr Lys Lys Val Arg Thr Asn Ala Ala Met 2885 2890 2895
Gly Ala Val Phe Thr Glu Glu Asn Gln Trp Asp Ser Ala Arg Ala 2900
2905 2910 Ala Val Glu Asp Glu Glu Phe Trp Lys Leu Val Asp Arg Glu
Arg 2915 2920 2925 Glu Leu His Lys Leu Gly Lys Cys Gly Ser Cys Val
Tyr Asn Met 2930 2935 2940 Met Gly Lys Arg Glu Lys Lys Leu Gly Glu
Phe Gly Lys Ala Lys 2945 2950 2955 Gly Ser Arg Ala Ile Trp Tyr Met
Trp Leu Gly Ala Arg Tyr Leu 2960 2965 2970 Glu Phe Glu Ala Leu Gly
Phe Leu Asn Glu Asp His Trp Phe Ser 2975 2980 2985 Arg Glu Asn Ser
Tyr Ser Gly Val Glu Gly Glu Gly Leu His Lys 2990 2995 3000 Leu Gly
Tyr Ile Leu Arg Asp Ile Ser Lys Ile Pro Gly Gly Ala 3005 3010 3015
Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile Thr Glu 3020
3025 3030 Asp Asp Leu His Asn Glu Glu Lys Ile Thr Gln Gln Met Asp
Pro 3035 3040 3045 Glu His Arg Gln Leu Ala Asn Ala Ile Phe Lys Leu
Thr Tyr Gln 3050 3055 3060 Asn Lys Val Val Lys Val Gln Arg Pro Thr
Pro Lys Gly Thr Val 3065 3070 3075 Met Asp Ile Ile Ser Arg Lys Asp
Gln Arg Gly Ser Gly Gln Val 3080 3085 3090 Gly Thr Tyr Gly Leu Asn
Thr Phe Thr Asn Met Glu Ala Gln Leu 3095 3100 3105 Ile Arg Gln Met
Glu Gly Glu Gly Val Leu Ser Lys Ala Asp Leu 3110 3115 3120 Glu Asn
Pro His Pro Leu Glu Lys Lys Ile Thr Gln Trp Leu Glu 3125 3130 3135
Thr Lys Gly Val Glu Arg Leu Lys Arg Met Ala Ile Ser Gly Asp 3140
3145 3150 Asp Cys Val Val Lys Pro Ile Asp Asp Arg Phe Ala Asn Ala
Leu 3155 3160 3165 Leu Ala Leu Asn Asp Met Gly Lys Val Arg Lys Asp
Ile Pro Gln 3170 3175 3180 Trp Gln Pro Ser Lys Gly Trp His Asp Trp
Gln Gln Val Pro Phe 3185 3190 3195 Cys Ser His His Phe His Glu Leu
Ile Met Lys Asp Gly Arg Lys 3200 3205 3210 Leu Val Val Pro Cys Arg
Pro Gln Asp Glu Leu Ile Gly Arg Ala 3215 3220 3225 Arg Ile Ser Gln
Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala Cys 3230 3235 3240 Leu Gly
Lys Ala Tyr Ala Gln Met Trp Ala Leu Met Tyr Phe His 3245 3250 3255
Arg Arg Asp Leu Arg Leu Ala Ser Asn Ala Ile Cys Ser Ala Val 3260
3265 3270 Pro Val His Trp Val Pro Thr Ser Arg Thr Thr Trp Ser Ile
His 3275 3280 3285 Ala His His Gln Trp Met Thr Thr Glu Asp Met Leu
Thr Val Trp 3290 3295 3300 Asn Arg Val Trp Ile Glu Asp Asn Pro Trp
Met Glu Asp Lys Thr 3305 3310 3315 Pro Val Thr Thr Trp Glu Asp Val
Pro Tyr Leu Gly Lys Arg Glu 3320 3325 3330 Asp Gln Trp Cys Gly Ser
Leu Ile Gly Leu Thr Ser Arg Ala Thr 3335 3340 3345 Trp Ala Gln Asn
Ile Leu Thr Ala Ile Gln Gln Val Arg Ser Leu 3350 3355 3360 Ile Gly
Asn Glu Glu Phe Leu Asp Tyr Met Pro Ser Met Lys Arg 3365 3370 3375
Phe Arg Lys Glu Glu Glu Ser Glu Gly Ala Ile Trp 3380 3385 3390
125PRTArtificialSynthetic construct 12Gly Ala Gly Lys Thr 1 5
135PRTArtificialSynthetic construct 13Gly Arg Ile Gly Arg 1 5
1410723DNAArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 1, MVS 14agttgttagt ctacgtggac cgacaaagac
agattctttg agggagctaa gctcaatgta 60gttctaacag ttttttaatt agagagcaga
tctctgatga ataaccaacg gaaaaaggcg 120aaaaacacgc ctttcaatat
gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag 180ctgacaaaga
gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg
240gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat
attgaagaga 300tggggaacaa ttaaaaaatc aaaagctatt aatgttttga
gagggttcag gaaagagatt 360ggaaggatgc tgaacatctt gaataggaga
cgcagatctg caggcatgat cattatgctg 420attccaacag tgatggcgtt
ccatttaacc acgcgtgggg gagagccgca tatgatagtt 480agcaagcagg
aaagaggaaa gtcacttttg ttcaagacct ctgcaggtgt caacatgtgc
540accctcattg cgatggattt gggagagttg tgtgaggaca cgatgaccta
caaatgcccc 600cggatcactg aggcggaacc agatgacgtt gactgttggt
gcaatgccac ggacacatgg 660gtgacctatg gaacgtgctc tcaaactggc
gaacaccgac gagacaaacg ttccgtcgca 720ttggccccac acgtggggct
tggcctagaa acaagagccg aaacgtggat gtcctctgaa 780ggtgcttgga
aacagataca aaaagtagag acttgggctc tgagacatcc aggattcacg
840gtgatagccc tttttctagc acatgccata ggaacatcca tcacccagaa
agggatcatt 900ttcattttgc tgatgctggt aacaccatct atggccatgc
gatgcgtggg aataggcaac 960agagacttcg tggaaggact gtcaggagca
acatgggtgg atgtggtact ggagcatgga 1020agttgcgtca ccaccatggc
aaaaaacaaa ccaacactgg acattgaact cttgaagacg 1080gaggtcacaa
accctgcagt tctgcgtaaa ttgtgcattg aagctaaaat atcaaacacc
1140accaccgatt cgagatgtcc aacacaagga gaagccacac tggtggaaga
acaagacgcg 1200aactttgtgt gccgacgaac gttcgtggac agaggctggg
gcaatggctg tgggctattc 1260ggaaaaggta gtctaataac gtgtgccaag
tttaagtgtg tgacaaaact agaaggaaag 1320atagttcaat atgaaaacct
aaaatattca gtgatagtca ccgtccacac tggagatcag 1380caccaggtgg
gaaatgagac tacagaacat ggaacaactg caaccataac acctcaagct
1440cctacgtcgg aaatacagct gaccgactac ggaaccctta cattagattg
ttcacctagg 1500acagggctag attttaacga gatggtgttg ctgacaatga
aagaaagatc atggcttgtc 1560cacaaacaat ggttcctaga cttaccactg
ccttggacct ctggggcttc aacatcccaa 1620gagacttgga acagacaaga
tttactggtc acatttaaga cagctcatgc aaagaagcag 1680gaagtagtcg
tactaggatc acaagaagga gcaatgcaca ctgcgctgac tggagcgaca
1740gaaatccaaa cgtcaggaac gacaacaatt ttcgcaggac acctaaaatg
cagactaaaa 1800atggacaaac taactttaaa agggatgtca tatgtgatgt
gcacaggctc attcaagtta 1860gagaaagaag tggctgagac ccagcatgga
actgttctgg tgcaggttaa atatgaagga 1920acagacgcac catgcaagat
tcccttttcg acccaagatg agaaaggagc aacccagaat 1980gggagattaa
taacagccaa ccccatagtc actgacaaag aaaaaccagt caatattgag
2040gcagaaccac cctttggtga gagctacatc gtggtaggag caggtgaaaa
agctttgaaa 2100ctaagctggt tcaagaaagg aagcagcata gggaaaatgt
ttgaagcaac tgcccgagga 2160gcacgaagga tggccattct gggagacacc
gcatgggact tcggttctat aggaggagtg 2220ttcacgtcta tgggaaaact
ggtacaccag gtttttggaa ctgcatatgg agttttgttt 2280agcggagttt
cttggaccat gaaaatagga atagggattc tgctgacatg gctaggatta
2340aattcaagga acacgtccct ttcgatgatg tgcatcgcag ccggcattgt
gacactgtat 2400ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga
gctggaaaaa caaagaactg 2460aaatgtggca gtgggatttt catcacagac
aacgtgcaca catggacaga acaatacaag 2520ttccaaccag aatccccttc
aaaactagct tcagctatcc agaaagccca tgaagaggac 2580atttgtggaa
tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca
2640gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac
aggagacatc 2700aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc
agcccactga gctgaagtat 2760tcatggaaaa catggggcaa agcaaaaatg
ctctctacag agtctcataa ccagaccttt 2820ctcattgatg gccccgaaac
agcagaatgc cccaacacaa atagagcttg gaattcgttg 2880gaagttgaag
actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa
2940aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga
caacagagcc 3000gtccatgccg atatgggtta ttggatagaa agtgcactca
atgacacatg gaagatagag 3060aaagcctctt tcattgaagt taaaaactgc
cactggccaa aatcacacac cctctggagc 3120aatggagtgc tagaaagtga
gatgataatt ccaaagaatc tcgctggacc agtgtctcaa 3180cacaactata
gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt
3240gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga
ctgcggaaat 3300agaggaccct ctttgagaac aaccactgcc tctggaaaac
tcataacaga atggtgctgc 3360cgatcttgca cattaccacc gctaagatac
agaggtgagg atgggtgctg gtacgggatg 3420gaaatcagac cattgaagga
gaaagaagag aatttggtca actccttggt cacagctgga 3480catgggcagg
tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa
3540atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt
ttcttttgtg 3600acattgatca cagggaacat gtcctttaga gacctgggaa
gagtgatggt tatggtaggc 3660gccactatga cggatgacat aggtatgggc
gtgacttatc ttgccctact agcagccttc 3720aaagtcagac caacttttgc
agctggacta ctcttgagaa agctgacctc caaggaattg 3780atgatgacta
ctataggaat tgtactcctc tcccagagca ccctaccaga gaccattctt
3840gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag
aaatatggaa 3900aagtatcaat tggcagtgac tatcatggct atcttgtgcg
tcccaaacgc agtgatatta 3960caaaacgcat ggaaagtgag ttgcacaata
ttggcagtgg tgtccgtttc cccactgttc 4020ttaacatcct cacagcaaaa
aacagattgg ataccattag cattgacgat caaaggtctc 4080aatccaacag
ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca
4140ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc
tctcctaaaa 4200aatgatattc ccatgacagg accattagtg gctggagggc
tcctcactgt gtgctacgtg 4260ctcactggac gatcggccga tttggaactg
gagagagcag ccgatgtcaa atgggaagac 4320caggcagaga tatcaggaag
cagtccaatc ctgtcaataa caatatcaga agatggtagc 4380atgtcgataa
aaaatgaaga ggaagatcaa acactgacca tactcattag aacaggattg
4440ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc
atggtacctg 4500tgggaagtga agaaacaacg ggccggagta ttgtgggatg
ttccttcacc cccacccatg 4560ggaaaggctg aactggaaga tggagcctat
agaattaagc aaaaagggat tcttggatat 4620tcccagatcg gagccggagt
ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca 4680cgtggcgctg
ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag
4740aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa
ggaaggagaa 4800gaagtccagg tattggcact ggagcctgga aaaaatccaa
gagccgtcca aacgaaacct 4860ggtcttttca aaaccaacgc cggaacaata
ggtgctgtat ctctggactt ttctcctgga 4920acgtcaggat ctccaattat
cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt 4980gttgttacaa
ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa
5040gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat
catggacctc 5100cacccaggag cgggaaagac gaagagatac cttccggcca
tagtcagaga agctataaaa 5160cggggtttga gaacattaat cttggccccc
actagagttg tggcagctga aatggaggaa 5220gcccttagag gacttccaat
aagataccag accccagcca tcagagctgt gcacaccggg 5280cgggagattg
tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt
5340agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga
cccagcaagt 5400atagcagcta gaggatacat ctcaactcga gtggagatgg
gtgaggcagc tgggattttt 5460atgacagcca ctcccccggg aagcagagac
ccatttcctc agagcaatgc accaatcata 5520gatgaagaaa gagaaatccc
tgaacgctcg tggaattccg gacatgaatg ggtcacggat 5580tttaaaggga
agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct
5640tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt
tgattctgag 5700tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta
caactgacat ttcagaaatg 5760ggtgccaatt tcaaggctga gagggttata
gaccccagac gctgcatgaa accagtcata 5820ctaacagatg gtgaagagcg
ggtgattctg gcaggaccta tgccagtgac ccactctagt 5880gcagcacaaa
gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata
5940tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga
agctaaaatg 6000ctcctagata acatcaacac gccagaagga atcattccta
gcatgttcga accagagcgt 6060gaaaaggtgg atgccattga tggcgaatac
cgcttgagag gagaagcaag gaaaaccttt 6120gtagacttaa tgagaagagg
agacctacca gtctggttgg cctacagagt ggcagctgaa 6180ggcatcaact
acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta
6240gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa
attgaaaccc 6300agatggttgg atgctaggat ctattctgac ccactggcgc
taaaagaatt taaggaattt 6360gcagccggaa gaaagtctct gaccctgaac
ctaatcacag aaatgggtag gctcccaacc 6420ttcatgactc agaaggcaag
agacgcactg gacaacttag cagtgctgca cacggctgag 6480gcaggtggaa
gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg
6540cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt
gatgagcgca 6600aggggcatag ggaagatgac cctgggaatg tgctgcataa
tcacggctag catcctccta 6660tggtacgcac aaatacagcc acactggata
gcagcttcaa taatactgga gttttttctc 6720atagttttgc ttattccaga
acctgaaaaa cagagaacac cccaagacaa ccaactgacc 6780tacgttgtca
tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc
6840ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca
acccgagagc 6900aacatcctgg acatagatct acgtcctgca tcagcatgga
cgctgtatgc cgtggccaca 6960acatttgtta caccaatgtt gagacatagc
attgaaaatt cctcagtgaa tgtgtcccta 7020acagctatag ccaaccaagc
cacagtgtta atgggtctcg ggaaaggatg gccattgtca 7080aagatggaca
tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata
7140actctcacag cagctctttt cttattggta gcacattatg ccatcatagg
gccaggactc 7200caagcaaaag caaccagaga agctcagaaa agagcagcgg
cgggcatcat gaaaaaccca 7260actgtcgatg gaataacagt gattgaccta
gatccaatac cttatgatcc gaagtttgaa 7320aagcagttgg gacaagtaat
gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg 7380actacatggg
ctctgtgtga ggctttaacc
ttagctaccg ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt
ttggaacact accattgcgg tgtcaatggc taacattttt 7500agagggagtt
acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac
7560acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa
aagccgattg 7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa
gtggaatcca ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga
ggagaaacgg accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg
gttcgttgag agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg
gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta
7860agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat
ccccatgtca 7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg
acgttttctt catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata
ggggagtcat caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt
ccttaactta gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa
aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta
8160caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc
cacacatgag 8220atgtactggg tatccaatgc ttccgggaac atagtgtcat
cagtgaacat gatttcaagg 8280atgttgatca acagatttac aatgagatac
aagaaagcca cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa
catcgggatt gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa
tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac
8460cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac
tggatcagca 8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac
cttgggacgt cgtccccatg 8580gtgacacaga tggcaatgac agacacgact
ccatttggac aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca
agaaccgaaa gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc
tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa
8760gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac
tgatgagaac 8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt
tttgggagct ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt
gaaacatgtg tgtacaacat gatgggaaaa 8940agagagaaga agctagggga
attcggcaag gcaaaaggca gcagagccat atggtacatg 9000tggcttggag
cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg
9060ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa
gctaggttac 9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt
atgccgatga caccgcagga 9180tgggatacaa gaatcacact agaagaccta
aaaaatgaag aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact
agccgaggcc attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc
aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac
9360caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa
tatggaagcc 9420caactaatca gacagatgga gggagaagga gtctttaaaa
gcattcagca cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta
gcaagagtgg ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga
ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc
taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca
9660agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca
tgagttaatc 9720atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc
aagatgaact gattggcaga 9780gcccgaatct cccaaggagc agggtggtct
ttgcgggaga cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt
gatgtacttc cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct
cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata
9960catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa
cagggtgtgg 10020attcaagaaa acccatggat ggaagacaaa actccagtgg
aatcatggga ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc
ggctcattga ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca
agcagcaata aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag
attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga
10260gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt
cggattaagc 10320catagtacgg aaaaaactat gctacctgtg agccccgtcc
aaggacgtta aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa
ctatgcagcc tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc
acaaaccatg gaagctgtac gcatggcgta gtggactagc 10500ggttagagga
gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga
10560agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa
caaaaaacag 10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc
tcagcatcat tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga
atcaacaggt tct 10723153391PRTArtificial SequencePolypeptide,
Derived from Dengue virus serotype 2/Dengue virus serotype 1, MVS
15Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 1
5 10 15 Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys
Arg 20 25 30 Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys
Leu Phe Met 35 40 45 Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile
Pro Pro Thr Ala Gly 50 55 60 Ile Leu Lys Arg Trp Gly Thr Ile Lys
Lys Ser Lys Ala Ile Asn Val 65 70 75 80 Leu Arg Gly Phe Arg Lys Glu
Ile Gly Arg Met Leu Asn Ile Leu Asn 85 90 95 Arg Arg Arg Arg Ser
Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 100 105 110 Met Ala Phe
His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 115 120 125 Ser
Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 130 135
140 Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu
145 150 155 160 Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala
Glu Pro Asp 165 170 175 Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr
Trp Val Thr Tyr Gly 180 185 190 Thr Cys Ser Gln Thr Gly Glu His Arg
Arg Asp Lys Arg Ser Val Ala 195 200 205 Leu Ala Pro His Val Gly Leu
Gly Leu Glu Thr Arg Ala Glu Thr Trp 210 215 220 Met Ser Ser Glu Gly
Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 225 230 235 240 Ala Leu
Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His 245 250 255
Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 260
265 270 Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly
Asn 275 280 285 Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val
Asp Val Val 290 295 300 Leu Glu His Gly Ser Cys Val Thr Thr Met Ala
Lys Asn Lys Pro Thr 305 310 315 320 Leu Asp Ile Glu Leu Leu Lys Thr
Glu Val Thr Asn Pro Ala Val Leu 325 330 335 Arg Lys Leu Cys Ile Glu
Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 340 345 350 Arg Cys Pro Thr
Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala 355 360 365 Asn Phe
Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 370 375 380
Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 385
390 395 400 Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn
Leu Lys 405 410 415 Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln
His Gln Val Gly 420 425 430 Asn Glu Thr Thr Glu His Gly Thr Thr Ala
Thr Ile Thr Pro Gln Ala 435 440 445 Pro Thr Ser Glu Ile Gln Leu Thr
Asp Tyr Gly Thr Leu Thr Leu Asp 450 455 460 Cys Ser Pro Arg Thr Gly
Leu Asp Phe Asn Glu Met Val Leu Leu Thr 465 470 475 480 Met Lys Glu
Arg Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 485 490 495 Pro
Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 500 505
510 Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln
515 520 525 Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr
Ala Leu 530 535 540 Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr
Thr Ile Phe Ala 545 550 555 560 Gly His Leu Lys Cys Arg Leu Lys Met
Asp Lys Leu Thr Leu Lys Gly 565 570 575 Met Ser Tyr Val Met Cys Thr
Gly Ser Phe Lys Leu Glu Lys Glu Val 580 585 590 Ala Glu Thr Gln His
Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 595 600 605 Thr Asp Ala
Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly 610 615 620 Ala
Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 625 630
635 640 Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu
Ser 645 650 655 Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu
Ser Trp Phe 660 665 670 Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu
Ala Thr Ala Arg Gly 675 680 685 Ala Arg Arg Met Ala Ile Leu Gly Asp
Thr Ala Trp Asp Phe Gly Ser 690 695 700 Ile Gly Gly Val Phe Thr Ser
Met Gly Lys Leu Val His Gln Val Phe 705 710 715 720 Gly Thr Ala Tyr
Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 725 730 735 Ile Gly
Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn 740 745 750
Thr Ser Leu Ser Met Met Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr 755
760 765 Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp
Lys 770 775 780 Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr
Asp Asn Val 785 790 795 800 His Thr Trp Thr Glu Gln Tyr Lys Phe Gln
Pro Glu Ser Pro Ser Lys 805 810 815 Leu Ala Ser Ala Ile Gln Lys Ala
His Glu Glu Asp Ile Cys Gly Ile 820 825 830 Arg Ser Val Thr Arg Leu
Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 835 840 845 Glu Leu Asn His
Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 850 855 860 Thr Gly
Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 865 870 875
880 Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala
885 890 895 Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile
Asp Gly 900 905 910 Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala
Trp Asn Ser Leu 915 920 925 Glu Val Glu Asp Tyr Gly Phe Gly Val Phe
Thr Thr Asn Ile Trp Leu 930 935 940 Lys Leu Lys Glu Lys Gln Asp Val
Phe Cys Asp Ser Lys Leu Met Ser 945 950 955 960 Ala Ala Ile Lys Asp
Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 965 970 975 Ile Glu Ser
Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 980 985 990 Ile
Glu Val Lys Asn Cys His Trp Pro Lys Ser His Thr Leu Trp Ser 995
1000 1005 Asn Gly Val Leu Glu Ser Glu Met Ile Ile Pro Lys Asn Leu
Ala 1010 1015 1020 Gly Pro Val Ser Gln His Asn Tyr Arg Pro Gly Tyr
His Thr Gln 1025 1030 1035 Ile Thr Gly Pro Trp His Leu Gly Lys Leu
Glu Met Asp Phe Asp 1040 1045 1050 Phe Cys Asp Gly Thr Thr Val Val
Val Thr Glu Asp Cys Gly Asn 1055 1060 1065 Arg Gly Pro Ser Leu Arg
Thr Thr Thr Ala Ser Gly Lys Leu Ile 1070 1075 1080 Thr Glu Trp Cys
Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg Tyr 1085 1090 1095 Arg Gly
Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Leu 1100 1105 1110
Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala Gly 1115
1120 1125 His Gly Gln Val Asp Asn Phe Ser Leu Gly Val Leu Gly Met
Ala 1130 1135 1140 Leu Phe Leu Glu Glu Met Leu Arg Thr Arg Val Gly
Thr Lys His 1145 1150 1155 Ala Ile Leu Leu Val Ala Val Ser Phe Val
Thr Leu Ile Thr Gly 1160 1165 1170 Asn Met Ser Phe Arg Asp Leu Gly
Arg Val Met Val Met Val Gly 1175 1180 1185 Ala Thr Met Thr Asp Asp
Ile Gly Met Gly Val Thr Tyr Leu Ala 1190 1195 1200 Leu Leu Ala Ala
Phe Lys Val Arg Pro Thr Phe Ala Ala Gly Leu 1205 1210 1215 Leu Leu
Arg Lys Leu Thr Ser Lys Glu Leu Met Met Thr Thr Ile 1220 1225 1230
Gly Ile Val Leu Leu Ser Gln Ser Thr Leu Pro Glu Thr Ile Leu 1235
1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly Met Met Val Leu Lys
Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr Gln Leu Ala Val Thr
Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro Asn Ala Val Ile Leu
Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys Thr Ile Leu Ala Val
Val Ser Val Ser Pro Leu Phe 1295 1300 1305 Leu Thr Ser Ser Gln Gln
Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315 1320 Thr Ile Lys Gly
Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu 1325 1330 1335 Ser Arg
Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile 1340 1345 1350
Met Ala Val Gly Met Val Ser Ile Leu Ala Ser Ser Leu Leu Lys 1355
1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu Val Ala Gly Gly Leu
Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr Gly Arg Ser Ala Asp
Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp Val Lys Trp Glu Asp
Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser Pro Ile Leu Ser Ile
Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met Ser Ile Lys Asn Glu
Glu Glu Asp Gln Thr Leu Thr Ile Leu 1430 1435 1440 Ile Arg Thr Gly
Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser 1445 1450 1455 Ile Pro
Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys 1460 1465 1470
Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro Pro Met 1475
1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala Tyr Arg Ile Lys Gln
Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln Ile Gly Ala Gly Val
Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr Met Trp His Val Thr
Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys Gly Lys Arg Ile Glu
Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys Asp Leu Ile Ser Tyr
Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555 1560 Trp Lys Glu Gly
Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly 1565 1570 1575 Lys Asn
Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe Lys Thr 1580 1585 1590
Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp Phe Ser Pro Gly 1595
1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly Lys Val Val
Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val Thr Arg Ser Gly Ala
Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr Glu Lys Ser Ile Glu
Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp Ile Phe Arg Lys Arg
Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His Pro Gly Ala Gly Lys
Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675 1680 Arg Glu Ala Ile
Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro 1685 1690 1695 Thr Arg
Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu 1700 1705 1710
Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala Val His Thr Gly 1715
1720 1725 Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe Thr Met
Arg 1730 1735 1740
Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Leu Ile Ile Met 1745
1750 1755 Asp Glu Ala His Phe Thr Asp Pro Ala Ser Ile Ala Ala Arg
Gly 1760 1765 1770 Tyr Ile Ser Thr Arg Val Glu Met Gly Glu Ala Ala
Gly Ile Phe 1775 1780 1785 Met Thr Ala Thr Pro Pro Gly Ser Arg Asp
Pro Phe Pro Gln Ser 1790 1795 1800 Asn Ala Pro Ile Ile Asp Glu Glu
Arg Glu Ile Pro Glu Arg Ser 1805 1810 1815 Trp Asn Ser Gly His Glu
Trp Val Thr Asp Phe Lys Gly Lys Thr 1820 1825 1830 Val Trp Phe Val
Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala Ala 1835 1840 1845 Cys Leu
Arg Lys Asn Gly Lys Lys Val Ile Gln Leu Ser Arg Lys 1850 1855 1860
Thr Phe Asp Ser Glu Tyr Val Lys Thr Arg Thr Asn Asp Trp Asp 1865
1870 1875 Phe Val Val Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe
Lys 1880 1885 1890 Ala Glu Arg Val Ile Asp Pro Arg Arg Cys Met Lys
Pro Val Ile 1895 1900 1905 Leu Thr Asp Gly Glu Glu Arg Val Ile Leu
Ala Gly Pro Met Pro 1910 1915 1920 Val Thr His Ser Ser Ala Ala Gln
Arg Arg Gly Arg Ile Gly Arg 1925 1930 1935 Asn Pro Lys Asn Glu Asn
Asp Gln Tyr Ile Tyr Met Gly Glu Pro 1940 1945 1950 Leu Glu Asn Asp
Glu Asp Cys Ala His Trp Lys Glu Ala Lys Met 1955 1960 1965 Leu Leu
Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile Pro Ser Met 1970 1975 1980
Phe Glu Pro Glu Arg Glu Lys Val Asp Ala Ile Asp Gly Glu Tyr 1985
1990 1995 Arg Leu Arg Gly Glu Ala Arg Lys Thr Phe Val Asp Leu Met
Arg 2000 2005 2010 Arg Gly Asp Leu Pro Val Trp Leu Ala Tyr Arg Val
Ala Ala Glu 2015 2020 2025 Gly Ile Asn Tyr Ala Asp Arg Arg Trp Cys
Phe Asp Gly Val Lys 2030 2035 2040 Asn Asn Gln Ile Leu Glu Glu Asn
Val Glu Val Glu Ile Trp Thr 2045 2050 2055 Lys Glu Gly Glu Arg Lys
Lys Leu Lys Pro Arg Trp Leu Asp Ala 2060 2065 2070 Arg Ile Tyr Ser
Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu Phe 2075 2080 2085 Ala Ala
Gly Arg Lys Ser Leu Thr Leu Asn Leu Ile Thr Glu Met 2090 2095 2100
Gly Arg Leu Pro Thr Phe Met Thr Gln Lys Ala Arg Asp Ala Leu 2105
2110 2115 Asp Asn Leu Ala Val Leu His Thr Ala Glu Ala Gly Gly Arg
Ala 2120 2125 2130 Tyr Asn His Ala Leu Ser Glu Leu Pro Glu Thr Leu
Glu Thr Leu 2135 2140 2145 Leu Leu Leu Thr Leu Leu Ala Thr Val Thr
Gly Gly Ile Phe Leu 2150 2155 2160 Phe Leu Met Ser Ala Arg Gly Ile
Gly Lys Met Thr Leu Gly Met 2165 2170 2175 Cys Cys Ile Ile Thr Ala
Ser Ile Leu Leu Trp Tyr Ala Gln Ile 2180 2185 2190 Gln Pro His Trp
Ile Ala Ala Ser Ile Ile Leu Glu Phe Phe Leu 2195 2200 2205 Ile Val
Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg Thr Pro Gln 2210 2215 2220
Asp Asn Gln Leu Thr Tyr Val Val Ile Ala Ile Leu Thr Val Val 2225
2230 2235 Ala Ala Thr Met Ala Asn Glu Met Gly Phe Leu Glu Lys Thr
Lys 2240 2245 2250 Lys Asp Leu Gly Leu Gly Ser Ile Ala Thr Gln Gln
Pro Glu Ser 2255 2260 2265 Asn Ile Leu Asp Ile Asp Leu Arg Pro Ala
Ser Ala Trp Thr Leu 2270 2275 2280 Tyr Ala Val Ala Thr Thr Phe Val
Thr Pro Met Leu Arg His Ser 2285 2290 2295 Ile Glu Asn Ser Ser Val
Asn Val Ser Leu Thr Ala Ile Ala Asn 2300 2305 2310 Gln Ala Thr Val
Leu Met Gly Leu Gly Lys Gly Trp Pro Leu Ser 2315 2320 2325 Lys Met
Asp Ile Gly Val Pro Leu Leu Ala Ile Gly Cys Tyr Ser 2330 2335 2340
Gln Val Asn Pro Ile Thr Leu Thr Ala Ala Leu Phe Leu Leu Val 2345
2350 2355 Ala His Tyr Ala Ile Ile Gly Pro Gly Leu Gln Ala Lys Ala
Thr 2360 2365 2370 Arg Glu Ala Gln Lys Arg Ala Ala Ala Gly Ile Met
Lys Asn Pro 2375 2380 2385 Thr Val Asp Gly Ile Thr Val Ile Asp Leu
Asp Pro Ile Pro Tyr 2390 2395 2400 Asp Pro Lys Phe Glu Lys Gln Leu
Gly Gln Val Met Leu Leu Val 2405 2410 2415 Leu Cys Val Thr Gln Val
Leu Met Met Arg Thr Thr Trp Ala Leu 2420 2425 2430 Cys Glu Ala Leu
Thr Leu Ala Thr Gly Pro Ile Ser Thr Leu Trp 2435 2440 2445 Glu Gly
Asn Pro Gly Arg Phe Trp Asn Thr Thr Ile Ala Val Ser 2450 2455 2460
Met Ala Asn Ile Phe Arg Gly Ser Tyr Leu Ala Gly Ala Gly Leu 2465
2470 2475 Leu Phe Ser Ile Met Lys Asn Thr Thr Asn Thr Arg Arg Gly
Thr 2480 2485 2490 Gly Asn Ile Gly Glu Thr Leu Gly Glu Lys Trp Lys
Ser Arg Leu 2495 2500 2505 Asn Ala Leu Gly Lys Ser Glu Phe Gln Ile
Tyr Lys Lys Ser Gly 2510 2515 2520 Ile Gln Glu Val Asp Arg Thr Leu
Ala Lys Glu Gly Ile Lys Arg 2525 2530 2535 Gly Glu Thr Asp His His
Ala Val Ser Arg Gly Ser Ala Lys Leu 2540 2545 2550 Arg Trp Phe Val
Glu Arg Asn Met Val Thr Pro Glu Gly Lys Val 2555 2560 2565 Val Asp
Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Cys Gly 2570 2575 2580
Gly Leu Lys Asn Val Arg Glu Val Lys Gly Leu Thr Lys Gly Gly 2585
2590 2595 Pro Gly His Glu Glu Pro Ile Pro Met Ser Thr Tyr Gly Trp
Asn 2600 2605 2610 Leu Val Arg Leu Gln Ser Gly Val Asp Val Phe Phe
Ile Pro Pro 2615 2620 2625 Glu Lys Cys Asp Thr Leu Leu Cys Asp Ile
Gly Glu Ser Ser Pro 2630 2635 2640 Asn Pro Thr Val Glu Ala Gly Arg
Thr Leu Arg Val Leu Asn Leu 2645 2650 2655 Val Glu Asn Trp Leu Asn
Asn Asn Thr Gln Phe Cys Ile Lys Val 2660 2665 2670 Leu Asn Pro Tyr
Met Pro Ser Val Ile Glu Lys Met Glu Ala Leu 2675 2680 2685 Gln Arg
Lys Tyr Gly Gly Ala Leu Val Arg Asn Pro Leu Ser Arg 2690 2695 2700
Asn Ser Thr His Glu Met Tyr Trp Val Ser Asn Ala Ser Gly Asn 2705
2710 2715 Ile Val Ser Ser Val Asn Met Ile Ser Arg Met Leu Ile Asn
Arg 2720 2725 2730 Phe Thr Met Arg Tyr Lys Lys Ala Thr Tyr Glu Pro
Asp Val Asp 2735 2740 2745 Leu Gly Ser Gly Thr Arg Asn Ile Gly Ile
Glu Ser Glu Ile Pro 2750 2755 2760 Asn Leu Asp Ile Ile Gly Lys Arg
Ile Glu Lys Ile Lys Gln Glu 2765 2770 2775 His Glu Thr Ser Trp His
Tyr Asp Gln Asp His Pro Tyr Lys Thr 2780 2785 2790 Trp Ala Tyr His
Gly Ser Tyr Glu Thr Lys Gln Thr Gly Ser Ala 2795 2800 2805 Ser Ser
Met Val Asn Gly Val Val Arg Leu Leu Thr Lys Pro Trp 2810 2815 2820
Asp Val Val Pro Met Val Thr Gln Met Ala Met Thr Asp Thr Thr 2825
2830 2835 Pro Phe Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr
Arg 2840 2845 2850 Thr Gln Glu Pro Lys Glu Gly Thr Lys Lys Leu Met
Lys Ile Thr 2855 2860 2865 Ala Glu Trp Leu Trp Lys Glu Leu Gly Lys
Lys Lys Thr Pro Arg 2870 2875 2880 Met Cys Thr Arg Glu Glu Phe Thr
Arg Lys Val Arg Ser Asn Ala 2885 2890 2895 Ala Leu Gly Ala Ile Phe
Thr Asp Glu Asn Lys Trp Lys Ser Ala 2900 2905 2910 Arg Glu Ala Val
Glu Asp Ser Arg Phe Trp Glu Leu Val Asp Lys 2915 2920 2925 Glu Arg
Asn Leu His Leu Glu Gly Lys Cys Glu Thr Cys Val Tyr 2930 2935 2940
Asn Met Met Gly Lys Arg Glu Lys Lys Leu Gly Glu Phe Gly Lys 2945
2950 2955 Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala
Arg 2960 2965 2970 Phe Leu Glu Phe Glu Ala Leu Gly Phe Leu Asn Glu
Asp His Trp 2975 2980 2985 Phe Ser Arg Glu Asn Ser Leu Ser Gly Val
Glu Gly Glu Gly Leu 2990 2995 3000 His Lys Leu Gly Tyr Ile Leu Arg
Asp Val Ser Lys Lys Glu Gly 3005 3010 3015 Gly Ala Met Tyr Ala Asp
Asp Thr Ala Gly Trp Asp Thr Arg Ile 3020 3025 3030 Thr Leu Glu Asp
Leu Lys Asn Glu Glu Met Val Thr Asn His Met 3035 3040 3045 Glu Gly
Glu His Lys Lys Leu Ala Glu Ala Ile Phe Lys Leu Thr 3050 3055 3060
Tyr Gln Asn Lys Val Val Arg Val Gln Arg Pro Thr Pro Arg Gly 3065
3070 3075 Thr Val Met Asp Ile Ile Ser Arg Arg Asp Gln Arg Gly Ser
Gly 3080 3085 3090 Gln Val Gly Thr Tyr Gly Leu Asn Thr Phe Thr Asn
Met Glu Ala 3095 3100 3105 Gln Leu Ile Arg Gln Met Glu Gly Glu Gly
Val Phe Lys Ser Ile 3110 3115 3120 Gln His Leu Thr Ile Thr Glu Glu
Ile Ala Val Gln Asn Trp Leu 3125 3130 3135 Ala Arg Val Gly Arg Glu
Arg Leu Ser Arg Met Ala Ile Ser Gly 3140 3145 3150 Asp Asp Cys Val
Val Lys Pro Leu Asp Asp Arg Phe Ala Ser Ala 3155 3160 3165 Leu Thr
Ala Leu Asn Asp Met Gly Lys Ile Arg Lys Asp Ile Gln 3170 3175 3180
Gln Trp Glu Pro Ser Arg Gly Trp Asn Asp Trp Thr Gln Val Pro 3185
3190 3195 Phe Cys Ser His His Phe His Glu Leu Ile Met Lys Asp Gly
Arg 3200 3205 3210 Val Leu Val Val Pro Cys Arg Asn Gln Asp Glu Leu
Ile Gly Arg 3215 3220 3225 Ala Arg Ile Ser Gln Gly Ala Gly Trp Ser
Leu Arg Glu Thr Ala 3230 3235 3240 Cys Leu Gly Lys Ser Tyr Ala Gln
Met Trp Ser Leu Met Tyr Phe 3245 3250 3255 His Arg Arg Asp Leu Arg
Leu Ala Ala Asn Ala Ile Cys Ser Ala 3260 3265 3270 Val Pro Ser His
Trp Val Pro Thr Ser Arg Thr Thr Trp Ser Ile 3275 3280 3285 His Ala
Lys His Glu Trp Met Thr Thr Glu Asp Met Leu Thr Val 3290 3295 3300
Trp Asn Arg Val Trp Ile Gln Glu Asn Pro Trp Met Glu Asp Lys 3305
3310 3315 Thr Pro Val Glu Ser Trp Glu Glu Ile Pro Tyr Leu Gly Lys
Arg 3320 3325 3330 Glu Asp Gln Trp Cys Gly Ser Leu Ile Gly Leu Thr
Ser Arg Ala 3335 3340 3345 Thr Trp Ala Lys Asn Ile Gln Ala Ala Ile
Asn Gln Val Arg Ser 3350 3355 3360 Leu Ile Gly Asn Glu Glu Tyr Thr
Asp Tyr Met Pro Ser Met Lys 3365 3370 3375 Arg Phe Arg Arg Glu Glu
Glu Glu Ala Gly Val Leu Trp 3380 3385 3390 1610723DNAArtificial
SequenceDerived from Dengue virus serotype 2, PDK-53 derivative,
MVS 16agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa
gctcaatgta 60gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg
gaaaaaggcg 120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc
gcgtgtcgac tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg
cagggacgag gaccattaaa actgttcatg 240gccctggtgg cgttccttcg
tttcctaaca atcccaccaa cagcagggat attgaagaga 300tggggaacaa
ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt
360ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat
cattatgctg 420attccaacag tgatggcgtt ccatttaacc acacgtaacg
gagaaccaca catgatcgtc 480agcagacaag agaaagggaa aagtcttctg
tttaaaacag aggttggcgt gaacatgtgt 540accctcatgg ccatggacct
tggtgaattg tgtgaagaca caatcacgta cgagtgtccc 600cttctcaggc
agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg
660gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag
atcagtggca 720ctcgttccac atgtgggaat gggactggag acacgaactg
aaacatggat gtcatcagaa 780ggggcctgga aacatgtcca gagaattgaa
acttggatct tgagacatcc aggcttcacc 840atgatggcag caatcctggc
atacaccata ggaacgacac atttccaaag agccctgatc 900ttcatcttac
tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat
960agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt
agaacatgga 1020agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg
attttgaact gataaaaaca 1080gaagccaaac agcctgccac cctaaggaag
tactgtatag aggcaaagct aaccaacaca 1140acaacagaat ctcgctgccc
aacacaaggg gaacccagcc taaatgaaga gcaggacaaa 1200aggttcgtct
gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt
1260ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat
ggaaggaaaa 1320gttgtgcaac cagaaaactt ggaatacacc attgtgataa
cacctcactc aggggaagag 1380catgcagtcg gaaatgacac aggaaaacat
ggcaaggaaa tcaaaataac accacagagt 1440tccatcacag aagcagaatt
gacaggttat ggcactgtca caatggagtg ctctccaaga 1500acgggcctcg
acttcaatga gatggtgttg ctgcagatgg aaaataaagc ttggctggtg
1560cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga
cacacaaggg 1620tcaaattgga tacagaaaga gacattggtc actttcaaaa
atccccatgc gaagaaacag 1680gatgttgttg ttttaggatc ccaagaaggg
gccatgcaca cagcacttac aggggccaca 1740gaaatccaaa tgtcatcagg
aaacttactc ttcacaggac atctcaagtg caggctgaga 1800atggacaagc
tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt
1860gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca
atatgaaggg 1920gacggctctc catgcaagat cccttttgag ataatggatt
tggaaaaaag acatgtctta 1980ggtcgcctga ttacagtcaa cccaattgtg
acagaaaaag atagcccagt caacatagaa 2040gcagaacctc catttggaga
cagctacatc atcataggag tagagccggg acaactgaag 2100ctcaactggt
ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg
2160gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt
gggaggagtg 2220tttacatcta taggaaaggc tctccaccaa gtctttggag
caatctatgg agctgccttc 2280agtggggttt catggactat gaaaatcctc
ataggagtca ttatcacatg gataggaatg 2340aattcacgca gcacctcact
gtctgtgaca ctagtattgg tgggaattgt gacactgtat 2400ttgggagtca
tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg
2460aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga
acaatacaag 2520ttccaaccag aatccccttc aaaactagct tcagctatcc
agaaagccca tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg
gagaatctga tgtggaaaca aataacacca 2640gaattgaatc acattctatc
agaaaatgag gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca
tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat
2760tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa
ccagaccttt 2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa
atagagcttg gaattcgttg 2880gaagttgaag actatggctt tggagtattc
accaccaata tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga
ctcaaaactc atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg
atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag
3060aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac
cctctggagc 3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc
tcgctggacc agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa
ataacaggac catggcatct aggtaagctt 3240gagatggact ttgatttctg
tgatggaaca acagtggtag tgactgagga ctgcggaaat 3300agaggaccct
ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc
3360cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg
gtacgggatg 3420gaaatcagac cattgaagga gaaagaagag aatttggtca
actccttggt cacagctgga 3480catgggcagg tcgacaactt ttcactagga
gtcttgggaa tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg
aacgaaacat gcaatactac tagttgcagt ttcttttgtg 3600acattgatca
cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc
3660gccactatga
cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
caaggaattg 3780atgatgacta ctataggaat tgtactcctc tcccagagca
ccataccaga gaccattctt 3840gagttgactg atgcgttagc cttaggcatg
atggtcctca aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac
tatcatggct atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat
ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc
4020ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat
caaaggtctc 4080aatccaacag ctatttttct aacaaccctc tcaagaacca
gcaagaaaag gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg
gtgagcattt tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg
accattagtg gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac
gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac
4320caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga
agatggtagc 4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca
tactcattag aacaggattg 4440ctggtgatct caggactttt tcctgtatca
ataccaatca cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg
ggccggagta ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg
aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat
4620tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg
gcatgtcaca 4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac
catcatgggc ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg
aagttagaag gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact
ggagcctgga aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca
aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga
4920acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta
tggtaatggt 4980gttgttacaa ggagtggagc atatgtgagt gctatagccc
agactgaaaa aagcattgaa 5040gacaacccag agatcgaaga tgacattttc
cgaaagagaa gactgaccat catggacctc 5100cacccaggag cgggaaagac
gaagagatac cttccggcca tagtcagaga agctataaaa 5160cggggtttga
gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa
5220gcccttagag gacttccaat aagataccag accccagcca tcagagctgt
gcacaccggg 5280cgggagattg tggacctaat gtgtcatgcc acatttacca
tgaggctgct atcaccagtt 5340agagtgccaa actacaacct gattatcatg
gacgaagccc atttcacaga cccagcaagt 5400atagcagcta gaggatacat
ctcaactcga gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca
ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata
5520gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg
ggtcacggat 5580tttaaaggga agactgtttg gttcgttcca agtataaaag
caggaaatga tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata
caactcagta ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa
tgattgggac ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt
tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata
5820ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac
ccactctagt 5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa
atgagaatga ccagtacata 5940tacatggggg aacctctgga aaatgatgaa
gactgtgcac actggaaaga agctaaaatg 6000ctcctagata acatcaacac
gccagaagga atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg
atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt
6120gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt
ggcagctgaa 6180ggcatcaact acgcagacag aaggtggtgt tttgatggag
tcaagaacaa ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca
aaagaagggg aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat
ctattctgac ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa
gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc
6420ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca
cacggctgag 6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc
cggagaccct ggagacattg 6540cttttactga cacttctggc tacagtcacg
ggagggatct ttttattctt gatgagcgca 6600aggggcatag ggaagatgac
cctgggaatg tgctgcataa tcacggctag catcctccta 6660tggtacgcac
aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc
6720atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa
ccaactgacc 6780tacgttgtca tagccatcct cacagtggtg gccgcaacca
tggcaaacga gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg
ggaagcattg caacccagca acccgagagc 6900aacatcctgg acatagatct
acgtcctgca tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta
caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta
7020acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg
gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc attggatgct
actcacaagt caaccccata 7140actctcacag cagctctttt cttattggta
gcacattatg ccatcatagg gccaggactc 7200caagcaaaag caaccagaga
agctcagaaa agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg
gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa
7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt
gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc ttagctaccg
ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact
accattgcgg tgtcaatggc taacattttt 7500agagggagtt acttggccgg
agctggactt ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg
gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg
7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca
ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg
accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag
agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag
aggaggctgg tcatactatt gtggaggact aaagaatgta 7860agagaagtca
aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca
7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt
catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat
caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta
gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa
cccatatatg ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat
atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag
8220atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat
gatttcaagg 8280atgttgatca acagatttac aatgagatac aagaaagcca
cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt
gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat
aaagcaagag catgaaacat catggcacta tgaccaagac 8460cacccataca
aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca
8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt
cgtccccatg 8580gtgacacaga tggcaatgac agacacgact ccatttggac
aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa
gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga
attagggaag aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa
gaaaggtgag aagcaatgca gccttggggg ccgtattcac tgatgagaac
8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct
ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg
tgtacaacat gatgggaaaa 8940agagagaaga agctagggga attcggcaag
gcaaaaggca gcagagccat atggtacatg 9000tggcttggag cacgcttctt
agagtttgaa gccctaggat tcttaaatga agatcactgg 9060ttctccagag
agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac
9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga
caccgcagga 9180tgggatacaa gaatcacact agaagaccta aaaaatgaag
aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc
attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac
accaagaggc acagtaatgg acatcatatc gagaagagac 9360caaagaggta
gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc
9420caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca
cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg
ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg
aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat
gggaaagatt aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga
atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc
9720atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact
gattggcaga 9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga
cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc
cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc
atcacattgg gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac
atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg
10020attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga
ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc ggctcattga
ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca agcagcaata
aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag attacatgcc
atccatgaaa agattcagaa gagaagagga agaagcagga 10260gttctgtggt
agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc
10320catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta
aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc
tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg
gaagctgtac gcatggcgta gtggactagc 10500ggttagagga gacccctccc
ttacaaatcg cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc
tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag
10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat
tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct
10723173391PRTArtificial SequenceDerived from Dengue virus serotype
2, PDK-53 derivative, MVS 17Met Asn Asn Gln Arg Lys Lys Ala Lys Asn
Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg Val Ser
Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly Met Leu
Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu Val Ala
Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60 Ile Leu
Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65 70 75 80
Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 85
90 95 Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr
Val 100 105 110 Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His
Met Ile Val 115 120 125 Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe
Lys Thr Glu Val Gly 130 135 140 Val Asn Met Cys Thr Leu Met Ala Met
Asp Leu Gly Glu Leu Cys Glu 145 150 155 160 Asp Thr Ile Thr Tyr Glu
Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu 165 170 175 Asp Ile Asp Cys
Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly 180 185 190 Thr Cys
Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala 195 200 205
Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp 210
215 220 Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr
Trp 225 230 235 240 Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala
Ile Leu Ala Tyr 245 250 255 Thr Ile Gly Thr Thr His Phe Gln Arg Ala
Leu Ile Phe Ile Leu Leu 260 265 270 Thr Ala Val Thr Pro Ser Met Thr
Met Arg Cys Ile Gly Met Ser Asn 275 280 285 Arg Asp Phe Val Glu Gly
Val Ser Gly Gly Ser Trp Val Asp Ile Val 290 295 300 Leu Glu His Gly
Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 305 310 315 320 Leu
Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu 325 330
335 Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser
340 345 350 Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln
Asp Lys 355 360 365 Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly
Trp Gly Asn Gly 370 375 380 Cys Gly Leu Phe Gly Lys Gly Gly Ile Val
Thr Cys Ala Met Phe Arg 385 390 395 400 Cys Lys Lys Asn Met Glu Gly
Lys Val Val Gln Pro Glu Asn Leu Glu 405 410 415 Tyr Thr Ile Val Ile
Thr Pro His Ser Gly Glu Glu His Ala Val Gly 420 425 430 Asn Asp Thr
Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser 435 440 445 Ser
Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu 450 455
460 Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln
465 470 475 480 Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe
Leu Asp Leu 485 490 495 Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln
Gly Ser Asn Trp Ile 500 505 510 Gln Lys Glu Thr Leu Val Thr Phe Lys
Asn Pro His Ala Lys Lys Gln 515 520 525 Asp Val Val Val Leu Gly Ser
Gln Glu Gly Ala Met His Thr Ala Leu 530 535 540 Thr Gly Ala Thr Glu
Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr 545 550 555 560 Gly His
Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly 565 570 575
Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile 580
585 590 Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu
Gly 595 600 605 Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp
Leu Glu Lys 610 615 620 Arg His Val Leu Gly Arg Leu Ile Thr Val Asn
Pro Ile Val Thr Glu 625 630 635 640 Lys Asp Ser Pro Val Asn Ile Glu
Ala Glu Pro Pro Phe Gly Asp Ser 645 650 655 Tyr Ile Ile Ile Gly Val
Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe 660 665 670 Lys Lys Gly Ser
Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly 675 680 685 Ala Lys
Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 690 695 700
Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe 705
710 715 720 Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr
Met Lys 725 730 735 Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met
Asn Ser Arg Ser 740 745 750 Thr Ser Leu Ser Val Thr Leu Val Leu Val
Gly Ile Val Thr Leu Tyr 755 760 765 Leu Gly Val Met Val Gln Ala Asp
Ser Gly Cys Val Val Ser Trp Lys 770 775 780 Asn Lys Glu Leu Lys Cys
Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 785 790 795 800 His Thr Trp
Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 805 810 815 Leu
Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 820 825
830 Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro
835 840 845 Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr
Ile Met 850 855 860 Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys
Arg Ser Leu Arg 865 870 875 880 Pro Gln Pro Thr Glu Leu Lys Tyr Ser
Trp Lys Thr Trp Gly Lys Ala 885 890 895 Lys Met Leu Ser Thr Glu Ser
His Asn Gln Thr Phe Leu Ile Asp Gly 900 905 910 Pro Glu Thr Ala Glu
Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 915 920 925 Glu Val Glu
Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 930 935 940 Lys
Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 945 950
955 960 Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr
Trp 965 970 975 Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys
Ala Ser Phe 980 985 990 Ile Glu Val Lys Asn Cys His Trp Pro Lys Ser
His Thr Leu Trp Ser 995 1000 1005 Asn Gly Val Leu Glu Ser Glu Met
Ile Ile Pro Lys Asn Leu Ala 1010 1015 1020 Gly Pro Val Ser Gln His
Asn Tyr Arg Pro Gly Tyr His Thr Gln 1025 1030 1035 Ile Thr Gly Pro
Trp His Leu Gly Lys Leu Glu Met Asp Phe Asp 1040 1045 1050 Phe Cys
Asp Gly Thr Thr Val Val Val Thr Glu Asp Cys Gly Asn 1055 1060 1065
Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser Gly Lys Leu Ile 1070
1075 1080 Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg
Tyr 1085 1090 1095 Arg Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile
Arg Pro Leu 1100 1105 1110 Lys Glu Lys Glu Glu Asn Leu Val Asn Ser
Leu Val Thr Ala Gly 1115 1120 1125 His Gly Gln Val Asp Asn Phe Ser
Leu Gly Val Leu Gly Met Ala 1130 1135 1140 Leu Phe Leu Glu Glu Met
Leu Arg Thr Arg Val Gly Thr Lys His 1145 1150 1155 Ala Ile Leu Leu
Val Ala Val Ser Phe Val Thr Leu Ile Thr Gly 1160 1165 1170 Asn Met
Ser Phe Arg Asp Leu Gly Arg Val Met Val Met Val Gly 1175 1180 1185
Ala Thr Met Thr Asp Asp Ile Gly Met Gly Val Thr Tyr Leu Ala 1190
1195
1200 Leu Leu Ala Ala Phe Lys Val Arg Pro Thr Phe Ala Ala Gly Leu
1205 1210 1215 Leu Leu Arg Lys Leu Thr Ser Lys Glu Leu Met Met Thr
Thr Ile 1220 1225 1230 Gly Ile Val Leu Leu Ser Gln Ser Thr Ile Pro
Glu Thr Ile Leu 1235 1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly
Met Met Val Leu Lys Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr
Gln Leu Ala Val Thr Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro
Asn Ala Val Ile Leu Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys
Thr Ile Leu Ala Val Val Ser Val Ser Pro Leu Phe 1295 1300 1305 Leu
Thr Ser Ser Gln Gln Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315
1320 Thr Ile Lys Gly Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu
1325 1330 1335 Ser Arg Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu
Ala Ile 1340 1345 1350 Met Ala Val Gly Met Val Ser Ile Leu Ala Ser
Ser Leu Leu Lys 1355 1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu
Val Ala Gly Gly Leu Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr
Gly Arg Ser Ala Asp Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp
Val Lys Trp Glu Asp Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser
Pro Ile Leu Ser Ile Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met
Ser Ile Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr Ile Leu 1430 1435
1440 Ile Arg Thr Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser
1445 1450 1455 Ile Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val
Lys Lys 1460 1465 1470 Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser
Pro Pro Pro Met 1475 1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala
Tyr Arg Ile Lys Gln Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln
Ile Gly Ala Gly Val Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr
Met Trp His Val Thr Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys
Gly Lys Arg Ile Glu Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys
Asp Leu Ile Ser Tyr Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555
1560 Trp Lys Glu Gly Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly
1565 1570 1575 Lys Asn Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe
Lys Thr 1580 1585 1590 Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp
Phe Ser Pro Gly 1595 1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys
Lys Gly Lys Val Val Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val
Thr Arg Ser Gly Ala Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr
Glu Lys Ser Ile Glu Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp
Ile Phe Arg Lys Arg Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His
Pro Gly Ala Gly Lys Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675
1680 Arg Glu Ala Ile Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro
1685 1690 1695 Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg
Gly Leu 1700 1705 1710 Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala
Val His Thr Gly 1715 1720 1725 Arg Glu Ile Val Asp Leu Met Cys His
Ala Thr Phe Thr Met Arg 1730 1735 1740 Leu Leu Ser Pro Val Arg Val
Pro Asn Tyr Asn Leu Ile Ile Met 1745 1750 1755 Asp Glu Ala His Phe
Thr Asp Pro Ala Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser
Thr Arg Val Glu Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met
Thr Ala Thr Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795
1800 Asn Ala Pro Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser
1805 1810 1815 Trp Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly
Lys Thr 1820 1825 1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn
Asp Ile Ala Ala 1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val
Ile Gln Leu Ser Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val
Lys Thr Arg Thr Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr
Asp Ile Ser Glu Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg
Val Ile Asp Pro Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu
Thr Asp Gly Glu Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915
1920 Val Thr His Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg
1925 1930 1935 Asn Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly
Glu Pro 1940 1945 1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys
Glu Ala Lys Met 1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu
Gly Ile Ile Pro Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys
Val Asp Ala Ile Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu
Ala Arg Lys Thr Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp
Leu Pro Val Trp Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly
Ile Asn Tyr Ala Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035
2040 Asn Asn Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr
2045 2050 2055 Lys Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu
Asp Ala 2060 2065 2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu
Phe Lys Glu Phe 2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu
Asn Leu Ile Thr Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met
Thr Gln Lys Ala Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val
Leu His Thr Ala Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His
Ala Leu Ser Glu Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu
Leu Leu Thr Leu Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155
2160 Phe Leu Met Ser Ala Arg Gly Ile Gly Lys Met Thr Leu Gly Met
2165 2170 2175 Cys Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala
Gln Ile 2180 2185 2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu
Glu Phe Phe Leu 2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu
Lys Gln Arg Thr Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val
Val Ile Ala Ile Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala
Asn Glu Met Gly Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu
Gly Leu Gly Ser Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn
Ile Leu Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275
2280 Tyr Ala Val Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser
2285 2290 2295 Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile
Ala Asn 2300 2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly
Trp Pro Leu Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu
Ala Ile Gly Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu
Thr Ala Ala Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile
Ile Gly Pro Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala
Gln Lys Arg Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr
Val Asp Gly Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395
2400 Asp Pro Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val
2405 2410 2415 Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp
Ala Leu 2420 2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile
Ser Thr Leu Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn
Thr Thr Ile Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly
Ser Tyr Leu Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met
Lys Asn Thr Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile
Gly Glu Thr Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn
Ala Leu Gly Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515
2520 Ile Gln Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg
2525 2530 2535 Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala
Lys Leu 2540 2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro
Glu Gly Lys Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly
Trp Ser Tyr Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu
Val Lys Gly Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu
Pro Ile Pro Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg
Leu Gln Ser Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu
Lys Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635
2640 Asn Pro Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu
2645 2650 2655 Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile
Lys Val 2660 2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys
Met Glu Ala Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val
Arg Asn Pro Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr
Trp Val Ser Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val
Asn Met Ile Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met
Arg Tyr Lys Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu
Gly Ser Gly Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755
2760 Asn Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu
2765 2770 2775 His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr
Lys Thr 2780 2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln
Thr Gly Ser Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg
Leu Leu Thr Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr
Gln Met Ala Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln
Arg Val Phe Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu
Pro Lys Glu Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala
Glu Trp Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875
2880 Met Cys Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala
2885 2890 2895 Ala Leu Gly Ala Val Phe Thr Asp Glu Asn Lys Trp Lys
Ser Ala 2900 2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu
Leu Val Asp Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys
Cys Glu Thr Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu
Lys Lys Leu Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg
Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu
Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe
Ser Arg Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995
3000 His Lys Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly
3005 3010 3015 Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr
Arg Ile 3020 3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val
Thr Asn His Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu
Ala Ile Phe Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg
Val Gln Arg Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile
Ile Ser Arg Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly
Thr Tyr Gly Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln
Leu Ile Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115
3120 Gln His Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu
3125 3130 3135 Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile
Ser Gly 3140 3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg
Phe Ala Ser Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys
Ile Arg Lys Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly
Trp Asn Asp Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His
Phe His Glu Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val
Val Pro Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala
Arg Ile Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235
3240 Cys Leu Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe
3245 3250 3255 His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys
Ser Ala 3260 3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr
Thr Trp Ser Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr
Glu Asp Met Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln
Glu Asn Pro Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser
Trp Glu Glu Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln
Trp Cys Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr
Trp Ala Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355
3360 Leu Ile Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys
3365 3370 3375 Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp
3380 3385 3390 1810717DNAArtificial SequenceDerived
from Dengue virus serotype 2/Dengue virus serotype 3, MVS
18agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta
60gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gagagccgcg
catgattgtg 480gggaagaatg aaagaggaaa atccctactt ttcaagacag
cctctggaat caacatgtgc 540acactcatag ctatggatct gggagagatg
tgtgatgaca cggtcactta caaatgcccc 600cacattaccg aagtggagcc
tgaagacatt gactgctggt gcaaccttac atcgacatgg 660gtgacttatg
gaacatgcaa tcaagctgga gagcatagac gcgataagag atcagtggcg
720ttagctcccc atgttggcat gggactggac acacgcactc aaacctggat
gtcggctgaa 780ggagcttgga gacaagtcga gaaggtagag acatgggccc
ttaggcaccc agggtttacc 840atactagccc tatttcttgc ccattacata
ggcacttcct tgacccagaa agtggttatt 900tttatactat taatgctggt
taccccatcc atgacaatga gatgtgtagg agtaggaaac 960agagattttg
tggaaggcct atcgggagct acgtgggttg acgtggtgct cgagcacggt
1020gggtgtgtga ctaccatggc taagaacaag cccacgctgg acatagagct
tcagaagacc 1080gaggccaccc aactggcgac cctaaggaag ctatgcattg
agggaaaaat taccaacata 1140acaaccgact caagatgtcc cacccaaggg
gaagcgattt tacctgagga gcaggaccag 1200aactacgtgt gtaagcatac
atacgtggac agaggctggg gaaacggttg tggtttgttt 1260ggcaagggaa
gcttggtgac atgcgcgaaa tttcaatgtt tagaatcaat agagggaaaa
1320gtggtgcaac atgagaacct caaatacacc gtcatcatca cagtgcacac
aggagaccaa 1380caccaggtgg gaaatgaaac gcagggagtc acggctgaga
taacacccca ggcatcaacc 1440gctgaagcca ttttacctga atatggaacc
ctcgggctag aatgctcacc acggacaggt 1500ttggatttca atgaaatgat
ctcattgaca atgaagaaca aagcatggat ggtacataga 1560caatggttct
ttgacttacc cctaccatgg acatcaggag cttcagcaga aacaccaact
1620tggaacagga aagagcttct tgtgacattt aaaaatgcac atgcaaaaaa
gcaagaagta 1680gttgttcttg gatcacaaga gggagcaatg catacagcac
tgacaggagc tacagagatc 1740caaacctcag gaggcacaag tatctttgcg
gggcacttaa aatgtagact caagatggac 1800aaattggaac tcaaggggat
gagctatgca atgtgcttga gtagctttgt gttgaagaaa 1860gaagtctccg
aaacgcagca tgggacaata ctcattaagg ttgagtacaa aggggaagat
1920gcaccctgca agattccttt ctccacggag gatggacaag gaaaagctct
caatggcaga 1980ctgatcacag ccaatccagt ggtgaccaag aaggaggagc
ctgtcaacat tgaggctgaa 2040cctccttttg gagaaagtaa catagtaatt
ggaattggag acaaagccct gaaaatcaac 2100tggtacaaga agggaagctc
gattgggaag atgttcgagg ccactgccag aggtgcaagg 2160cgcatggcca
tcttgggaga cacagcctgg gactttggat cagtgggtgg tgttttgaat
2220tcattaggga aaatggtcca ccaaatattt gggagtgctt acacagccct
atttggtgga 2280gtctcctgga tgatgaaaat tggaataggt gtcctcttaa
cctggatagg gttgaactca 2340aaaaatactt ctatgtcatt ttcatgcatc
gcggccggca ttgtgacact gtatttggga 2400gtcatggtgc aggccgatag
tggttgcgtt gtgagctgga aaaacaaaga actgaaatgt 2460ggcagtggga
ttttcatcac agacaacgtg cacacatgga cagaacaata caagttccaa
2520ccagaatccc cttcaaaact agcttcagct atccagaaag cccatgaaga
ggacatttgt 2580ggaatccgct cagtaacaag actggagaat ctgatgtgga
aacaaataac accagaattg 2640aatcacattc tatcagaaaa tgaggtgaag
ttaactatta tgacaggaga catcaaagga 2700atcatgcagg caggaaaacg
atctctgcgg cctcagccca ctgagctgaa gtattcatgg 2760aaaacatggg
gcaaagcaaa aatgctctct acagagtctc ataaccagac ctttctcatt
2820gatggccccg aaacagcaga atgccccaac acaaatagag cttggaattc
gttggaagtt 2880gaagactatg gctttggagt attcaccacc aatatatggc
taaaattgaa agaaaaacag 2940gatgtattct gcgactcaaa actcatgtca
gcggccataa aagacaacag agccgtccat 3000gccgatatgg gttattggat
agaaagtgca ctcaatgaca catggaagat agagaaagcc 3060tctttcattg
aagttaaaaa ctgccactgg ccaaaatcac acaccctctg gagcaatgga
3120gtgctagaaa gtgagatgat aattccaaag aatctcgctg gaccagtgtc
tcaacacaac 3180tatagaccag gctaccatac acaaataaca ggaccatggc
atctaggtaa gcttgagatg 3240gactttgatt tctgtgatgg aacaacagtg
gtagtgactg aggactgcgg aaatagagga 3300ccctctttga gaacaaccac
tgcctctgga aaactcataa cagaatggtg ctgccgatct 3360tgcacattac
caccgctaag atacagaggt gaggatgggt gctggtacgg gatggaaatc
3420agaccattga aggagaaaga agagaatttg gtcaactcct tggtcacagc
tggacatggg 3480caggtcgaca acttttcact aggagtcttg ggaatggcat
tgttcctgga ggaaatgctt 3540aggacccgag taggaacgaa acatgcaata
ctactagttg cagtttcttt tgtgacattg 3600atcacaggga acatgtcctt
tagagacctg ggaagagtga tggttatggt aggcgccact 3660atgacggatg
acataggtat gggcgtgact tatcttgccc tactagcagc cttcaaagtc
3720agaccaactt ttgcagctgg actactcttg agaaagctga cctccaagga
attgatgatg 3780actactatag gaattgtact cctctcccag agcaccatac
cagagaccat tcttgagttg 3840actgatgcgt tagccttagg catgatggtc
ctcaaaatgg tgagaaatat ggaaaagtat 3900caattggcag tgactatcat
ggctatcttg tgcgtcccaa acgcagtgat attacaaaac 3960gcatggaaag
tgagttgcac aatattggca gtggtgtccg tttccccact gttcttaaca
4020tcctcacagc aaaaaacaga ttggatacca ttagcattga cgatcaaagg
tctcaatcca 4080acagctattt ttctaacaac cctctcaaga accagcaaga
aaaggagctg gccattaaat 4140gaggctatca tggcagtcgg gatggtgagc
attttagcca gttctctcct aaaaaatgat 4200attcccatga caggaccatt
agtggctgga gggctcctca ctgtgtgcta cgtgctcact 4260ggacgatcgg
ccgatttgga actggagaga gcagccgatg tcaaatggga agaccaggca
4320gagatatcag gaagcagtcc aatcctgtca ataacaatat cagaagatgg
tagcatgtcg 4380ataaaaaatg aagaggaaga acaaacactg accatactca
ttagaacagg attgctggtg 4440atctcaggac tttttcctgt atcaatacca
atcacggcag cagcatggta cctgtgggaa 4500gtgaagaaac aacgggccgg
agtattgtgg gatgttcctt cacccccacc catgggaaag 4560gctgaactgg
aagatggagc ctatagaatt aagcaaaaag ggattcttgg atattcccag
4620atcggagccg gagtttacaa agaaggaaca ttccatacaa tgtggcatgt
cacacgtggc 4680gctgttctaa tgcataaagg aaagaggatt gaaccatcat
gggcggacgt caagaaagac 4740ctaatatcat atggaggagg ctggaagtta
gaaggagaat ggaaggaagg agaagaagtc 4800caggtattgg cactggagcc
tggaaaaaat ccaagagccg tccaaacgaa acctggtctt 4860ttcaaaacca
acgccggaac aataggtgct gtatctctgg acttttctcc tggaacgtca
4920ggatctccaa ttatcgacaa aaaaggaaaa gttgtgggtc tttatggtaa
tggtgttgtt 4980acaaggagtg gagcatatgt gagtgctata gcccagactg
aaaaaagcat tgaagacaac 5040ccagagatcg aagatgacat tttccgaaag
agaagactga ccatcatgga cctccaccca 5100ggagcgggaa agacgaagag
ataccttccg gccatagtca gagaagctat aaaacggggt 5160ttgagaacat
taatcttggc ccccactaga gttgtggcag ctgaaatgga ggaagccctt
5220agaggacttc caataagata ccagacccca gccatcagag ctgtgcacac
cgggcgggag 5280attgtggacc taatgtgtca tgccacattt accatgaggc
tgctatcacc agttagagtg 5340ccaaactaca acctgattat catggacgaa
gcccatttca cagacccagc aagtatagca 5400gctagaggat acatctcaac
tcgagtggag atgggtgagg cagctgggat ttttatgaca 5460gccactcccc
cgggaagcag agacccattt cctcagagca atgcaccaat catagatgaa
5520gaaagagaaa tccctgaacg ctcgtggaat tccggacatg aatgggtcac
ggattttaaa 5580gggaagactg tttggttcgt tccaagtata aaagcaggaa
atgatatagc agcttgcctg 5640aggaaaaatg gaaagaaagt gatacaactc
agtaggaaga cctttgattc tgagtatgtc 5700aagactagaa ccaatgattg
ggacttcgtg gttacaactg acatttcaga aatgggtgcc 5760aatttcaagg
ctgagagggt tatagacccc agacgctgca tgaaaccagt catactaaca
5820gatggtgaag agcgggtgat tctggcagga cctatgccag tgacccactc
tagtgcagca 5880caaagaagag ggagaatagg aagaaatcca aaaaatgaga
atgaccagta catatacatg 5940ggggaacctc tggaaaatga tgaagactgt
gcacactgga aagaagctaa aatgctccta 6000gataacatca acacgccaga
aggaatcatt cctagcatgt tcgaaccaga gcgtgaaaag 6060gtggatgcca
ttgatggcga ataccgcttg agaggagaag caaggaaaac ctttgtagac
6120ttaatgagaa gaggagacct accagtctgg ttggcctaca gagtggcagc
tgaaggcatc 6180aactacgcag acagaaggtg gtgttttgat ggagtcaaga
acaaccaaat cctagaagaa 6240aacgtggaag ttgaaatctg gacaaaagaa
ggggaaagga agaaattgaa acccagatgg 6300ttggatgcta ggatctattc
tgacccactg gcgctaaaag aatttaagga atttgcagcc 6360ggaagaaagt
ctctgaccct gaacctaatc acagaaatgg gtaggctccc aaccttcatg
6420actcagaagg caagagacgc actggacaac ttagcagtgc tgcacacggc
tgaggcaggt 6480ggaagggcgt acaaccatgc tctcagtgaa ctgccggaga
ccctggagac attgctttta 6540ctgacacttc tggctacagt cacgggaggg
atctttttat tcttgatgag cgcaaggggc 6600atagggaaga tgaccctggg
aatgtgctgc ataatcacgg ctagcatcct cctatggtac 6660gcacaaatac
agccacactg gatagcagct tcaataatac tggagttttt tctcatagtt
6720ttgcttattc cagaacctga aaaacagaga acaccccaag acaaccaact
gacctacgtt 6780gtcatagcca tcctcacagt ggtggccgca accatggcaa
acgagatggg tttcctagaa 6840aaaacgaaga aagatctcgg attgggaagc
attgcaaccc agcaacccga gagcaacatc 6900ctggacatag atctacgtcc
tgcatcagca tggacgctgt atgccgtggc cacaacattt 6960gttacaccaa
tgttgagaca tagcattgaa aattcctcag tgaatgtgtc cctaacagct
7020atagccaacc aagccacagt gttaatgggt ctcgggaaag gatggccatt
gtcaaagatg 7080gacatcggag ttccccttct cgccattgga tgctactcac
aagtcaaccc cataactctc 7140acagcagctc ttttcttatt ggtagcacat
tatgccatca tagggccagg actccaagca 7200aaagcaacca gagaagctca
gaaaagagca gcggcgggca tcatgaaaaa cccaactgtc 7260gatggaataa
cagtgattga cctagatcca ataccttatg atccaaagtt tgaaaagcag
7320ttgggacaag taatgctcct agtcctctgc gtgactcaag tattgatgat
gaggactaca 7380tgggctctgt gtgaggcttt aaccttagct accgggccca
tctccacatt gtgggaagga 7440aatccaggga ggttttggaa cactaccatt
gcggtgtcaa tggctaacat ttttagaggg 7500agttacttgg ccggagctgg
acttctcttt tctattatga agaacacaac caacacaaga 7560aggggaactg
gcaacatagg agagacgctt ggagagaaat ggaaaagccg attgaacgcg
7620ttgggaaaaa gtgaattcca gatctacaag aaaagtggaa tccaggaagt
ggatagaacc 7680ttagcaaaag aaggcattaa aagaggagaa acggaccatc
acgctgtgtc gcgaggctca 7740gcaaaactga gatggttcgt tgagagaaac
atggtcacac cagaagggaa agtagtggac 7800ctcggttgtg gcagaggagg
ctggtcatac tattgtggag gactaaagaa tgtaagagaa 7860gtcaaaggcc
taacaaaagg aggaccagga cacgaagaac ccatccccat gtcaacatat
7920gggtggaatc tagtgcgtct tcaaagtgga gttgacgttt tcttcatccc
gccagaaaag 7980tgtgacacat tattgtgtga cataggggag tcatcaccaa
atcccacagt ggaagcagga 8040cgaacactca gagtccttaa cttagtagaa
aattggttga acaacaacac tcaattttgc 8100ataaaggttc tcaacccata
tatgccctca gtcatagaaa aaatggaagc actacaaagg 8160aaatatggag
gagccttagt gaggaatcca ctctcacgaa actccacaca tgagatgtac
8220tgggtatcca atgcttccgg gaacatagtg tcatcagtga acatgatttc
aaggatgttg 8280atcaacagat ttacaatgag atacaagaaa gccacttacg
agccggatgt tgacctcgga 8340agcggaaccc gtaacatcgg gattgaaagt
gagataccaa acctagatat aattgggaaa 8400agaatagaaa aaataaagca
agagcatgaa acatcatggc actatgacca agaccaccca 8460tacaaaacgt
gggcatacca tggtagctat gaaacaaaac agactggatc agcatcatcc
8520atggtcaacg gagtggtcag gctgctgaca aaaccttggg acgtcgtccc
catggtgaca 8580cagatggcaa tgacagacac gactccattt ggacaacagc
gcgtttttaa agagaaagtg 8640gacacgagaa cccaagaacc gaaagaaggc
acgaagaaac taatgaaaat aacagcagag 8700tggctttgga aagaattagg
gaagaaaaag acacccagga tgtgcaccag agaagaattc 8760acaagaaagg
tgagaagcaa tgcagccttg ggggccatat tcactgatga gaacaagtgg
8820aagtcggcac gtgaggctgt tgaagatagt aggttttggg agctggttga
caaggaaagg 8880aatctccatc ttgaaggaaa gtgtgaaaca tgtgtgtaca
acatgatggg aaaaagagag 8940aagaagctag gggaattcgg caaggcaaaa
ggcagcagag ccatatggta catgtggctt 9000ggagcacgct tcttagagtt
tgaagcccta ggattcttaa atgaagatca ctggttctcc 9060agagagaact
ccctgagtgg agtggaagga gaagggctgc acaagctagg ttacattcta
9120agagacgtga gcaagaaaga gggaggagca atgtatgccg atgacaccgc
aggatgggat 9180acaagaatca cactagaaga cctaaaaaat gaagaaatgg
taacaaacca catggaagga 9240gaacacaaga aactagccga ggccattttc
aaactaacgt accaaaacaa ggtggtgcgt 9300gtgcaaagac caacaccaag
aggcacagta atggacatca tatcgagaag agaccaaaga 9360ggtagtggac
aagttggcac ctatggactc aatactttca ccaatatgga agcccaacta
9420atcagacaga tggagggaga aggagtcttt aaaagcattc agcacctaac
aatcacagaa 9480gaaatcgctg tgcaaaactg gttagcaaga gtggggcgcg
aaaggttatc aagaatggcc 9540atcagtggag atgattgtgt tgtgaaacct
ttagatgaca ggttcgcaag cgctttaaca 9600gctctaaatg acatgggaaa
gattaggaaa gacatacaac aatgggaacc ttcaagagga 9660tggaatgatt
ggacacaagt gcccttctgt tcacaccatt tccatgagtt aatcatgaaa
9720gacggtcgcg tactcgttgt tccatgtaga aaccaagatg aactgattgg
cagagcccga 9780atctcccaag gagcagggtg gtctttgcgg gagacggcct
gtttggggaa gtcttacgcc 9840caaatgtgga gcttgatgta cttccacaga
cgcgacctca ggctggcggc aaatgctatt 9900tgctcggcag taccatcaca
ttgggttcca acaagtcgaa caacctggtc catacatgct 9960aaacatgaat
ggatgacaac ggaagacatg ctgacagtct ggaacagggt gtggattcaa
10020gaaaacccat ggatggaaga caaaactcca gtggaatcat gggaggaaat
cccatacttg 10080gggaaaagag aagaccaatg gtgcggctca ttgattgggt
taacaagcag ggccacctgg 10140gcaaagaaca tccaagcagc aataaatcaa
gttagatccc ttataggcaa tgaagaatac 10200acagattaca tgccatccat
gaaaagattc agaagagaag aggaagaagc aggagttctg 10260tggtagaaag
caaaactaac atgaaacaag gctagaagtc aggtcggatt aagccatagt
10320acggaaaaaa ctatgctacc tgtgagcccc gtccaaggac gttaaaagaa
gtcaggccat 10380cataaatgcc atagcttgag taaactatgc agcctgtagc
tccacctgag aaggtgtaaa 10440aaatccggga ggccacaaac catggaagct
gtacgcatgg cgtagtggac tagcggttag 10500aggagacccc tcccttacaa
atcgcagcaa caatgggggc ccaaggcgag atgaagctgt 10560agtctcgctg
gaaggactag aggttagagg agaccccccc gaaacaaaaa acagcatatt
10620gacgctggga aagaccagag atcctgctgt ctcctcagca tcattccagg
cacagaacgc 10680cagaaaatgg aatggtgctg ttgaatcaac aggttct
10717193389PRTArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 3, MVS 19Met Asn Asn Gln Arg Lys Lys Ala
Lys Asn Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg
Val Ser Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly
Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu
Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60
Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65
70 75 80 Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile
Leu Asn 85 90 95 Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu
Ile Pro Thr Val 100 105 110 Met Ala Phe His Leu Thr Thr Arg Asp Gly
Glu Pro Arg Met Ile Val 115 120 125 Gly Lys Asn Glu Arg Gly Lys Ser
Leu Leu Phe Lys Thr Ala Ser Gly 130 135 140 Ile Asn Met Cys Thr Leu
Ile Ala Met Asp Leu Gly Glu Met Cys Asp 145 150 155 160 Asp Thr Val
Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu 165 170 175 Asp
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly 180 185
190 Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala
195 200 205 Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln
Thr Trp 210 215 220 Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys
Val Glu Thr Trp 225 230 235 240 Ala Leu Arg His Pro Gly Phe Thr Ile
Leu Ala Leu Phe Leu Ala His 245 250 255 Tyr Ile Gly Thr Ser Leu Thr
Gln Lys Val Val Ile Phe Ile Leu Leu 260 265 270 Met Leu Val Thr Pro
Ser Met Thr Met Arg Cys Val Gly Val Gly Asn 275 280 285 Arg Asp Phe
Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 290 295 300 Leu
Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 305 310
315 320 Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr
Leu 325 330 335 Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr
Thr Asp Ser 340 345 350 Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro
Glu Glu Gln Asp Gln 355 360 365 Asn Tyr Val Cys Lys His Thr Tyr Val
Asp Arg Gly Trp Gly Asn Gly 370 375 380 Cys Gly Leu Phe Gly Lys Gly
Ser Leu Val Thr Cys Ala Lys Phe Gln 385 390 395 400 Cys Leu Glu Ser
Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys 405 410 415 Tyr Thr
Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly 420 425 430
Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr 435
440 445 Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys
Ser 450 455 460 Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu
Thr Met Lys 465 470 475 480 Asn Lys Ala Trp Met Val His Arg Gln Trp
Phe Phe Asp Leu Pro Leu 485 490 495 Pro Trp Thr Ser Gly Ala Ser Ala
Glu Thr Pro Thr Trp Asn Arg Lys 500 505 510 Glu Leu Leu Val Thr Phe
Lys Asn Ala His Ala Lys Lys Gln Glu Val 515 520 525 Val Val Leu Gly
Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 530 535 540 Ala Thr
Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe Ala Gly His 545 550 555
560 Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser
565 570 575 Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu Val
Ser Glu 580 585 590 Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr
Lys Gly Glu Asp 595 600 605 Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu
Asp Gly Gln Gly Lys Ala 610 615 620 Leu Asn Gly Arg Leu Ile Thr Ala
Asn Pro Val Val Thr Lys Lys Glu 625 630 635
640 Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile
645 650 655 Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr
Lys Lys 660 665 670 Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala
Arg Gly Ala Arg 675 680 685 Arg Met Ala Ile Leu Gly Asp Thr Ala Trp
Asp Phe Gly Ser Val Gly 690 695 700 Gly Val Leu Asn Ser Leu Gly Lys
Met Val His Gln Ile Phe Gly Ser 705 710 715 720 Ala Tyr Thr Ala Leu
Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly 725 730 735 Ile Gly Val
Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser 740 745 750 Met
Ser Phe Ser Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr Leu Gly 755 760
765 Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys
770 775 780 Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val
His Thr 785 790 795 800 Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser
Pro Ser Lys Leu Ala 805 810 815 Ser Ala Ile Gln Lys Ala His Glu Glu
Asp Ile Cys Gly Ile Arg Ser 820 825 830 Val Thr Arg Leu Glu Asn Leu
Met Trp Lys Gln Ile Thr Pro Glu Leu 835 840 845 Asn His Ile Leu Ser
Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly 850 855 860 Asp Ile Lys
Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln 865 870 875 880
Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met 885
890 895 Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly Pro
Glu 900 905 910 Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser
Leu Glu Val 915 920 925 Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn
Ile Trp Leu Lys Leu 930 935 940 Lys Glu Lys Gln Asp Val Phe Cys Asp
Ser Lys Leu Met Ser Ala Ala 945 950 955 960 Ile Lys Asp Asn Arg Ala
Val His Ala Asp Met Gly Tyr Trp Ile Glu 965 970 975 Ser Ala Leu Asn
Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu 980 985 990 Val Lys
Asn Cys His Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly 995 1000
1005 Val Leu Glu Ser Glu Met Ile Ile Pro Lys Asn Leu Ala Gly Pro
1010 1015 1020 Val Ser Gln His Asn Tyr Arg Pro Gly Tyr His Thr Gln
Ile Thr 1025 1030 1035 Gly Pro Trp His Leu Gly Lys Leu Glu Met Asp
Phe Asp Phe Cys 1040 1045 1050 Asp Gly Thr Thr Val Val Val Thr Glu
Asp Cys Gly Asn Arg Gly 1055 1060 1065 Pro Ser Leu Arg Thr Thr Thr
Ala Ser Gly Lys Leu Ile Thr Glu 1070 1075 1080 Trp Cys Cys Arg Ser
Cys Thr Leu Pro Pro Leu Arg Tyr Arg Gly 1085 1090 1095 Glu Asp Gly
Cys Trp Tyr Gly Met Glu Ile Arg Pro Leu Lys Glu 1100 1105 1110 Lys
Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala Gly His Gly 1115 1120
1125 Gln Val Asp Asn Phe Ser Leu Gly Val Leu Gly Met Ala Leu Phe
1130 1135 1140 Leu Glu Glu Met Leu Arg Thr Arg Val Gly Thr Lys His
Ala Ile 1145 1150 1155 Leu Leu Val Ala Val Ser Phe Val Thr Leu Ile
Thr Gly Asn Met 1160 1165 1170 Ser Phe Arg Asp Leu Gly Arg Val Met
Val Met Val Gly Ala Thr 1175 1180 1185 Met Thr Asp Asp Ile Gly Met
Gly Val Thr Tyr Leu Ala Leu Leu 1190 1195 1200 Ala Ala Phe Lys Val
Arg Pro Thr Phe Ala Ala Gly Leu Leu Leu 1205 1210 1215 Arg Lys Leu
Thr Ser Lys Glu Leu Met Met Thr Thr Ile Gly Ile 1220 1225 1230 Val
Leu Leu Ser Gln Ser Thr Ile Pro Glu Thr Ile Leu Glu Leu 1235 1240
1245 Thr Asp Ala Leu Ala Leu Gly Met Met Val Leu Lys Met Val Arg
1250 1255 1260 Asn Met Glu Lys Tyr Gln Leu Ala Val Thr Ile Met Ala
Ile Leu 1265 1270 1275 Cys Val Pro Asn Ala Val Ile Leu Gln Asn Ala
Trp Lys Val Ser 1280 1285 1290 Cys Thr Ile Leu Ala Val Val Ser Val
Ser Pro Leu Phe Leu Thr 1295 1300 1305 Ser Ser Gln Gln Lys Thr Asp
Trp Ile Pro Leu Ala Leu Thr Ile 1310 1315 1320 Lys Gly Leu Asn Pro
Thr Ala Ile Phe Leu Thr Thr Leu Ser Arg 1325 1330 1335 Thr Ser Lys
Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile Met Ala 1340 1345 1350 Val
Gly Met Val Ser Ile Leu Ala Ser Ser Leu Leu Lys Asn Asp 1355 1360
1365 Ile Pro Met Thr Gly Pro Leu Val Ala Gly Gly Leu Leu Thr Val
1370 1375 1380 Cys Tyr Val Leu Thr Gly Arg Ser Ala Asp Leu Glu Leu
Glu Arg 1385 1390 1395 Ala Ala Asp Val Lys Trp Glu Asp Gln Ala Glu
Ile Ser Gly Ser 1400 1405 1410 Ser Pro Ile Leu Ser Ile Thr Ile Ser
Glu Asp Gly Ser Met Ser 1415 1420 1425 Ile Lys Asn Glu Glu Glu Glu
Gln Thr Leu Thr Ile Leu Ile Arg 1430 1435 1440 Thr Gly Leu Leu Val
Ile Ser Gly Leu Phe Pro Val Ser Ile Pro 1445 1450 1455 Ile Thr Ala
Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys Gln Arg 1460 1465 1470 Ala
Gly Val Leu Trp Asp Val Pro Ser Pro Pro Pro Met Gly Lys 1475 1480
1485 Ala Glu Leu Glu Asp Gly Ala Tyr Arg Ile Lys Gln Lys Gly Ile
1490 1495 1500 Leu Gly Tyr Ser Gln Ile Gly Ala Gly Val Tyr Lys Glu
Gly Thr 1505 1510 1515 Phe His Thr Met Trp His Val Thr Arg Gly Ala
Val Leu Met His 1520 1525 1530 Lys Gly Lys Arg Ile Glu Pro Ser Trp
Ala Asp Val Lys Lys Asp 1535 1540 1545 Leu Ile Ser Tyr Gly Gly Gly
Trp Lys Leu Glu Gly Glu Trp Lys 1550 1555 1560 Glu Gly Glu Glu Val
Gln Val Leu Ala Leu Glu Pro Gly Lys Asn 1565 1570 1575 Pro Arg Ala
Val Gln Thr Lys Pro Gly Leu Phe Lys Thr Asn Ala 1580 1585 1590 Gly
Thr Ile Gly Ala Val Ser Leu Asp Phe Ser Pro Gly Thr Ser 1595 1600
1605 Gly Ser Pro Ile Ile Asp Lys Lys Gly Lys Val Val Gly Leu Tyr
1610 1615 1620 Gly Asn Gly Val Val Thr Arg Ser Gly Ala Tyr Val Ser
Ala Ile 1625 1630 1635 Ala Gln Thr Glu Lys Ser Ile Glu Asp Asn Pro
Glu Ile Glu Asp 1640 1645 1650 Asp Ile Phe Arg Lys Arg Arg Leu Thr
Ile Met Asp Leu His Pro 1655 1660 1665 Gly Ala Gly Lys Thr Lys Arg
Tyr Leu Pro Ala Ile Val Arg Glu 1670 1675 1680 Ala Ile Lys Arg Gly
Leu Arg Thr Leu Ile Leu Ala Pro Thr Arg 1685 1690 1695 Val Val Ala
Ala Glu Met Glu Glu Ala Leu Arg Gly Leu Pro Ile 1700 1705 1710 Arg
Tyr Gln Thr Pro Ala Ile Arg Ala Val His Thr Gly Arg Glu 1715 1720
1725 Ile Val Asp Leu Met Cys His Ala Thr Phe Thr Met Arg Leu Leu
1730 1735 1740 Ser Pro Val Arg Val Pro Asn Tyr Asn Leu Ile Ile Met
Asp Glu 1745 1750 1755 Ala His Phe Thr Asp Pro Ala Ser Ile Ala Ala
Arg Gly Tyr Ile 1760 1765 1770 Ser Thr Arg Val Glu Met Gly Glu Ala
Ala Gly Ile Phe Met Thr 1775 1780 1785 Ala Thr Pro Pro Gly Ser Arg
Asp Pro Phe Pro Gln Ser Asn Ala 1790 1795 1800 Pro Ile Ile Asp Glu
Glu Arg Glu Ile Pro Glu Arg Ser Trp Asn 1805 1810 1815 Ser Gly His
Glu Trp Val Thr Asp Phe Lys Gly Lys Thr Val Trp 1820 1825 1830 Phe
Val Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala Ala Cys Leu 1835 1840
1845 Arg Lys Asn Gly Lys Lys Val Ile Gln Leu Ser Arg Lys Thr Phe
1850 1855 1860 Asp Ser Glu Tyr Val Lys Thr Arg Thr Asn Asp Trp Asp
Phe Val 1865 1870 1875 Val Thr Thr Asp Ile Ser Glu Met Gly Ala Asn
Phe Lys Ala Glu 1880 1885 1890 Arg Val Ile Asp Pro Arg Arg Cys Met
Lys Pro Val Ile Leu Thr 1895 1900 1905 Asp Gly Glu Glu Arg Val Ile
Leu Ala Gly Pro Met Pro Val Thr 1910 1915 1920 His Ser Ser Ala Ala
Gln Arg Arg Gly Arg Ile Gly Arg Asn Pro 1925 1930 1935 Lys Asn Glu
Asn Asp Gln Tyr Ile Tyr Met Gly Glu Pro Leu Glu 1940 1945 1950 Asn
Asp Glu Asp Cys Ala His Trp Lys Glu Ala Lys Met Leu Leu 1955 1960
1965 Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile Pro Ser Met Phe Glu
1970 1975 1980 Pro Glu Arg Glu Lys Val Asp Ala Ile Asp Gly Glu Tyr
Arg Leu 1985 1990 1995 Arg Gly Glu Ala Arg Lys Thr Phe Val Asp Leu
Met Arg Arg Gly 2000 2005 2010 Asp Leu Pro Val Trp Leu Ala Tyr Arg
Val Ala Ala Glu Gly Ile 2015 2020 2025 Asn Tyr Ala Asp Arg Arg Trp
Cys Phe Asp Gly Val Lys Asn Asn 2030 2035 2040 Gln Ile Leu Glu Glu
Asn Val Glu Val Glu Ile Trp Thr Lys Glu 2045 2050 2055 Gly Glu Arg
Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala Arg Ile 2060 2065 2070 Tyr
Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu Phe Ala Ala 2075 2080
2085 Gly Arg Lys Ser Leu Thr Leu Asn Leu Ile Thr Glu Met Gly Arg
2090 2095 2100 Leu Pro Thr Phe Met Thr Gln Lys Ala Arg Asp Ala Leu
Asp Asn 2105 2110 2115 Leu Ala Val Leu His Thr Ala Glu Ala Gly Gly
Arg Ala Tyr Asn 2120 2125 2130 His Ala Leu Ser Glu Leu Pro Glu Thr
Leu Glu Thr Leu Leu Leu 2135 2140 2145 Leu Thr Leu Leu Ala Thr Val
Thr Gly Gly Ile Phe Leu Phe Leu 2150 2155 2160 Met Ser Ala Arg Gly
Ile Gly Lys Met Thr Leu Gly Met Cys Cys 2165 2170 2175 Ile Ile Thr
Ala Ser Ile Leu Leu Trp Tyr Ala Gln Ile Gln Pro 2180 2185 2190 His
Trp Ile Ala Ala Ser Ile Ile Leu Glu Phe Phe Leu Ile Val 2195 2200
2205 Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg Thr Pro Gln Asp Asn
2210 2215 2220 Gln Leu Thr Tyr Val Val Ile Ala Ile Leu Thr Val Val
Ala Ala 2225 2230 2235 Thr Met Ala Asn Glu Met Gly Phe Leu Glu Lys
Thr Lys Lys Asp 2240 2245 2250 Leu Gly Leu Gly Ser Ile Ala Thr Gln
Gln Pro Glu Ser Asn Ile 2255 2260 2265 Leu Asp Ile Asp Leu Arg Pro
Ala Ser Ala Trp Thr Leu Tyr Ala 2270 2275 2280 Val Ala Thr Thr Phe
Val Thr Pro Met Leu Arg His Ser Ile Glu 2285 2290 2295 Asn Ser Ser
Val Asn Val Ser Leu Thr Ala Ile Ala Asn Gln Ala 2300 2305 2310 Thr
Val Leu Met Gly Leu Gly Lys Gly Trp Pro Leu Ser Lys Met 2315 2320
2325 Asp Ile Gly Val Pro Leu Leu Ala Ile Gly Cys Tyr Ser Gln Val
2330 2335 2340 Asn Pro Ile Thr Leu Thr Ala Ala Leu Phe Leu Leu Val
Ala His 2345 2350 2355 Tyr Ala Ile Ile Gly Pro Gly Leu Gln Ala Lys
Ala Thr Arg Glu 2360 2365 2370 Ala Gln Lys Arg Ala Ala Ala Gly Ile
Met Lys Asn Pro Thr Val 2375 2380 2385 Asp Gly Ile Thr Val Ile Asp
Leu Asp Pro Ile Pro Tyr Asp Pro 2390 2395 2400 Lys Phe Glu Lys Gln
Leu Gly Gln Val Met Leu Leu Val Leu Cys 2405 2410 2415 Val Thr Gln
Val Leu Met Met Arg Thr Thr Trp Ala Leu Cys Glu 2420 2425 2430 Ala
Leu Thr Leu Ala Thr Gly Pro Ile Ser Thr Leu Trp Glu Gly 2435 2440
2445 Asn Pro Gly Arg Phe Trp Asn Thr Thr Ile Ala Val Ser Met Ala
2450 2455 2460 Asn Ile Phe Arg Gly Ser Tyr Leu Ala Gly Ala Gly Leu
Leu Phe 2465 2470 2475 Ser Ile Met Lys Asn Thr Thr Asn Thr Arg Arg
Gly Thr Gly Asn 2480 2485 2490 Ile Gly Glu Thr Leu Gly Glu Lys Trp
Lys Ser Arg Leu Asn Ala 2495 2500 2505 Leu Gly Lys Ser Glu Phe Gln
Ile Tyr Lys Lys Ser Gly Ile Gln 2510 2515 2520 Glu Val Asp Arg Thr
Leu Ala Lys Glu Gly Ile Lys Arg Gly Glu 2525 2530 2535 Thr Asp His
His Ala Val Ser Arg Gly Ser Ala Lys Leu Arg Trp 2540 2545 2550 Phe
Val Glu Arg Asn Met Val Thr Pro Glu Gly Lys Val Val Asp 2555 2560
2565 Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Cys Gly Gly Leu
2570 2575 2580 Lys Asn Val Arg Glu Val Lys Gly Leu Thr Lys Gly Gly
Pro Gly 2585 2590 2595 His Glu Glu Pro Ile Pro Met Ser Thr Tyr Gly
Trp Asn Leu Val 2600 2605 2610 Arg Leu Gln Ser Gly Val Asp Val Phe
Phe Ile Pro Pro Glu Lys 2615 2620 2625 Cys Asp Thr Leu Leu Cys Asp
Ile Gly Glu Ser Ser Pro Asn Pro 2630 2635 2640 Thr Val Glu Ala Gly
Arg Thr Leu Arg Val Leu Asn Leu Val Glu 2645 2650 2655 Asn Trp Leu
Asn Asn Asn Thr Gln Phe Cys Ile Lys Val Leu Asn 2660 2665 2670 Pro
Tyr Met Pro Ser Val Ile Glu Lys Met Glu Ala Leu Gln Arg 2675 2680
2685 Lys Tyr Gly Gly Ala Leu Val Arg Asn Pro Leu Ser Arg Asn Ser
2690 2695 2700 Thr His Glu Met Tyr Trp Val Ser Asn Ala Ser Gly Asn
Ile Val 2705 2710 2715 Ser Ser Val Asn Met Ile Ser Arg Met Leu Ile
Asn Arg Phe Thr 2720 2725 2730 Met Arg Tyr Lys Lys Ala Thr Tyr Glu
Pro Asp Val Asp Leu Gly 2735 2740 2745 Ser Gly Thr Arg Asn Ile Gly
Ile Glu Ser Glu Ile Pro Asn Leu 2750 2755 2760 Asp Ile Ile Gly Lys
Arg Ile Glu Lys Ile Lys Gln Glu His Glu 2765 2770 2775 Thr Ser Trp
His Tyr Asp Gln Asp His Pro Tyr Lys Thr Trp Ala 2780 2785 2790 Tyr
His Gly Ser Tyr Glu Thr Lys Gln Thr Gly Ser Ala Ser Ser 2795 2800
2805 Met Val Asn Gly Val Val Arg Leu Leu Thr Lys Pro Trp Asp Val
2810 2815 2820 Val Pro Met Val Thr Gln Met Ala Met Thr Asp Thr Thr
Pro Phe 2825 2830 2835 Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp
Thr Arg Thr Gln 2840 2845
2850 Glu Pro Lys Glu Gly Thr Lys Lys Leu Met Lys Ile Thr Ala Glu
2855 2860 2865 Trp Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg
Met Cys 2870 2875 2880 Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser
Asn Ala Ala Leu 2885 2890 2895 Gly Ala Ile Phe Thr Asp Glu Asn Lys
Trp Lys Ser Ala Arg Glu 2900 2905 2910 Ala Val Glu Asp Ser Arg Phe
Trp Glu Leu Val Asp Lys Glu Arg 2915 2920 2925 Asn Leu His Leu Glu
Gly Lys Cys Glu Thr Cys Val Tyr Asn Met 2930 2935 2940 Met Gly Lys
Arg Glu Lys Lys Leu Gly Glu Phe Gly Lys Ala Lys 2945 2950 2955 Gly
Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg Phe Leu 2960 2965
2970 Glu Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp Phe Ser
2975 2980 2985 Arg Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu
His Lys 2990 2995 3000 Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys
Glu Gly Gly Ala 3005 3010 3015 Met Tyr Ala Asp Asp Thr Ala Gly Trp
Asp Thr Arg Ile Thr Leu 3020 3025 3030 Glu Asp Leu Lys Asn Glu Glu
Met Val Thr Asn His Met Glu Gly 3035 3040 3045 Glu His Lys Lys Leu
Ala Glu Ala Ile Phe Lys Leu Thr Tyr Gln 3050 3055 3060 Asn Lys Val
Val Arg Val Gln Arg Pro Thr Pro Arg Gly Thr Val 3065 3070 3075 Met
Asp Ile Ile Ser Arg Arg Asp Gln Arg Gly Ser Gly Gln Val 3080 3085
3090 Gly Thr Tyr Gly Leu Asn Thr Phe Thr Asn Met Glu Ala Gln Leu
3095 3100 3105 Ile Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile
Gln His 3110 3115 3120 Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn
Trp Leu Ala Arg 3125 3130 3135 Val Gly Arg Glu Arg Leu Ser Arg Met
Ala Ile Ser Gly Asp Asp 3140 3145 3150 Cys Val Val Lys Pro Leu Asp
Asp Arg Phe Ala Ser Ala Leu Thr 3155 3160 3165 Ala Leu Asn Asp Met
Gly Lys Ile Arg Lys Asp Ile Gln Gln Trp 3170 3175 3180 Glu Pro Ser
Arg Gly Trp Asn Asp Trp Thr Gln Val Pro Phe Cys 3185 3190 3195 Ser
His His Phe His Glu Leu Ile Met Lys Asp Gly Arg Val Leu 3200 3205
3210 Val Val Pro Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg Ala Arg
3215 3220 3225 Ile Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala
Cys Leu 3230 3235 3240 Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met
Tyr Phe His Arg 3245 3250 3255 Arg Asp Leu Arg Leu Ala Ala Asn Ala
Ile Cys Ser Ala Val Pro 3260 3265 3270 Ser His Trp Val Pro Thr Ser
Arg Thr Thr Trp Ser Ile His Ala 3275 3280 3285 Lys His Glu Trp Met
Thr Thr Glu Asp Met Leu Thr Val Trp Asn 3290 3295 3300 Arg Val Trp
Ile Gln Glu Asn Pro Trp Met Glu Asp Lys Thr Pro 3305 3310 3315 Val
Glu Ser Trp Glu Glu Ile Pro Tyr Leu Gly Lys Arg Glu Asp 3320 3325
3330 Gln Trp Cys Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala Thr Trp
3335 3340 3345 Ala Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser
Leu Ile 3350 3355 3360 Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser
Met Lys Arg Phe 3365 3370 3375 Arg Arg Glu Glu Glu Glu Ala Gly Val
Leu Trp 3380 3385 2010723DNAArtificial SequenceDerived from Dengue
virus serotype 2/Dengue virus serotype 4, MVS 20agttgttagt
ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta 60gttctaacag
ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gacctttaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtgaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg
aaaacgatct ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa
catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt
2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg
gaattcgttg 2880gaagttgaag actatggctt tggagtattc accaccaata
tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc
atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg atatgggtta
ttggatagaa agtgcactca atgacacatg gaagatagag 3060aaagcctctt
tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc
3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc
agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa ataacaggac
catggcatct aggtaagctt 3240gagatggact ttgatttctg tgatggaaca
acagtggtag tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac
aaccactgcc tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca
cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg
3420gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt
cacagctgga 3480catgggcagg tcgacaactt ttcactagga gtcttgggaa
tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat
gcaatactac tagttgcagt ttcttttgtg 3600acattgatca cagggaacat
gtcctttaga gacctgggaa gagtgatggt tatggtaggc 3660gccactatga
cgggtgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
cagggaattg 3780atgatgacta ctataggaat tgtactcctc tcccagagca
ccataccaga gaccattctt 3840gagttgactg atgcgttagc cttaggcatg
atggtcctca aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac
tatcatggct atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat
ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc
4020ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat
caaaggtctc 4080aatccaacag ctatttttct aacaaccctc tcaagaacca
gcaagaaaag gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg
gtgagcattt tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg
accattagtg gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac
gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac
4320caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga
agatggtagc 4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca
tactcattag aacaggattg 4440ctggtgatct caggactttt tcctgtatca
ataccaatca cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg
ggccggagta ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg
aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat
4620tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg
gcatgtcaca 4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac
catcatgggc ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg
aagttagaag gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact
ggagcctgga aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca
aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga
4920acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta
tggtaatggt 4980gttgttacaa ggagtggagc atatgtgagt gctatagccc
agactgaaaa aagcattgaa 5040gacaacccag agatcgaaga tgacattttc
cgaaagagaa gactgaccat catggacctc 5100cacccaggag cgggaaagac
gaagagatac cttccggcca tagtcagaga agctataaaa 5160cggggtttga
gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa
5220gcccttagag gacttccaat aagataccag accccagcca tcagagctgt
gcacaccggg 5280cgggagattg tggacctaat gtgtcatgcc acatttacca
tgaggctgct atcaccagtt 5340agagtgccaa actacaacct gattatcatg
gacgaagccc atttcacaga tccagcaagt 5400atagcagcta gaggatacat
ctcaactcga gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca
ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata
5520gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg
ggtcacggat 5580tttaaaggga agactgtttg gttcgttcca agtataaaag
caggaaatga tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata
caactcagta ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa
tgattgggac ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt
tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata
5820ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac
ccactctagt 5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa
atgagaatga ccagtacata 5940tacatggggg aacctctgga aaatgatgaa
gactgtgcac actggaaaga agctaaaatg 6000ctcctagata acatcaacac
gccagaagga atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg
atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt
6120gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt
ggcagctgaa 6180ggcatcaact acgcagacag aaggtggtgt tttgatggag
tcaagaacaa ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca
aaagaagggg aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat
ctattctgac ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa
gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc
6420ttcatgactc agaaggtaag agacgcactg gacaacttag cagtgctgca
cacggctgag 6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc
cggagaccct ggagacattg 6540cttttactga cacttctggc tacagtcacg
ggagggatct ttttattctt gatgagcgca 6600aggggcatag ggaagatgac
cctgggaatg tgctgcataa tcacggctag catcctccta 6660tggtacgcac
aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc
6720atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa
ccaactgacc 6780tacgttgtca tagccatcct cacagtggtg gccgcaacca
tggcaaacga gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg
ggaagcattg caacccagca acccgagagc 6900aacatcctgg acatagatct
acgtcctgca tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta
caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta
7020acagccatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg
gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc attggatgct
actcacaagt caaccccata 7140actctcacag cagctctttt cttattggta
gcacattatg ccatcatagg gccaggactc 7200caagcaaaag caaccagaga
agctcagaaa agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg
gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa
7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt
gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc ttagctaccg
ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact
accattgcgg tgtcaatggc taacattttt 7500agagggagtt acttggccgg
agctggactt ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg
gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg
7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca
ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg
accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag
agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag
aggaggctgg tcatactatt gtggaggact aaagaatgta 7860agagaagtca
aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca
7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt
catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat
caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta
gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa
cccatatatg ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat
atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag
8220atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat
gatttcaagg 8280atgttgatca acagatttac aatgagatac aagaaagcca
cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt
gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat
aaagcaagag catgaaacat catggcacta tgaccaagac 8460cacccataca
aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca
8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt
cgtccccatg 8580gtgacacaga tggcaatgac agacacgact ccatttggac
aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa
gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga
attagggaag aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa
gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac
8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct
ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg
tgtacaacat gatgggaaaa 8940agagagaaga agctagggga attcggcaag
gcaaaaggca gcagagccat atggtacatg 9000tggcttggag cacgcttctt
agagtttgaa gccctaggat tcttaaatga agatcactgg 9060ttctccagag
agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac
9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga
caccgcagga 9180tgggatacaa gaatcacact agaagaccta aaaaatgaag
aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc
attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac
accaagaggc acagtaatgg acatcatatc gagaagagac 9360caaagaggta
gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc
9420caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca
cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg
ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg
aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat
gggaaagatt aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga
atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc
9720atgaaagacg gtcgcgtact cgttgttccc tgtagaaacc aagatgaact
gattggcaga 9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga
cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc
cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc
atcacattgg gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac
atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg
10020attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga
ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc ggctcattga
ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca agcagcaata
aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag attacatgcc
atccatgaaa agattcagaa gagaagagga agaagcagga 10260gttctgtggt
agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc
10320catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta
aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc
tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg
gaagctgtac gcatggcgta gtggactagc 10500ggttagagga gacccctccc
ttacaaatcg cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc
tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag
10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat
tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct
10723213391PRTArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 4, MVS 21Met Asn Asn Gln Arg Lys Lys Ala
Lys Asn Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg
Val Ser Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly
Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu
Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60
Ile Leu Lys Arg Trp Gly
Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65 70 75 80 Leu Arg Gly Phe
Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 85 90 95 Arg Arg
Arg Ser Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 100 105 110
Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val 115
120 125 Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu
Gly 130 135 140 Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu
Met Cys Glu 145 150 155 160 Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu
Val Asn Thr Glu Pro Glu 165 170 175 Asp Ile Asp Cys Trp Cys Asn Leu
Thr Ser Thr Trp Val Met Tyr Gly 180 185 190 Thr Cys Thr Gln Ser Gly
Glu Arg Arg Arg Glu Lys Arg Ser Val Ala 195 200 205 Leu Thr Pro His
Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp 210 215 220 Met Ser
Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 225 230 235
240 Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr
245 250 255 Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val
Leu Met 260 265 270 Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val
Gly Val Gly Asn 275 280 285 Arg Asp Phe Val Glu Gly Val Ser Gly Gly
Ala Trp Val Asp Leu Val 290 295 300 Leu Glu His Gly Gly Cys Val Thr
Thr Met Ala Gln Gly Lys Pro Thr 305 310 315 320 Leu Asp Phe Glu Leu
Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu 325 330 335 Arg Thr Tyr
Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 340 345 350 Arg
Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 355 360
365 Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly
370 375 380 Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys
Phe Ser 385 390 395 400 Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln
Ile Glu Asn Leu Glu 405 410 415 Tyr Thr Val Val Val Thr Val His Asn
Gly Asp Thr His Ala Val Gly 420 425 430 Asn Asp Thr Ser Asn His Gly
Val Thr Ala Thr Ile Thr Pro Arg Ser 435 440 445 Pro Ser Val Glu Val
Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp 450 455 460 Cys Glu Pro
Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys 465 470 475 480
Met Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 485
490 495 Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp
Asn 500 505 510 Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala
Lys Arg Gln 515 520 525 Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala
Met His Ser Ala Leu 530 535 540 Ala Gly Ala Thr Glu Val Asp Ser Gly
Asp Gly Asn His Met Phe Ala 545 550 555 560 Gly His Leu Lys Cys Lys
Val Arg Met Glu Lys Leu Arg Ile Lys Gly 565 570 575 Met Ser Tyr Thr
Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met 580 585 590 Ala Glu
Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 595 600 605
Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys 610
615 620 Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu
Asn 625 630 635 640 Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro
Phe Gly Asp Ser 645 650 655 Tyr Ile Val Ile Gly Val Gly Asn Ser Ala
Leu Thr Leu His Trp Phe 660 665 670 Arg Lys Gly Ser Ser Ile Gly Lys
Met Phe Glu Ser Thr Tyr Arg Gly 675 680 685 Ala Lys Arg Met Ala Ile
Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser 690 695 700 Val Gly Gly Leu
Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe 705 710 715 720 Gly
Ser Val Tyr Thr Thr Leu Phe Gly Gly Val Ser Trp Met Ile Arg 725 730
735 Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn
740 745 750 Thr Ser Met Ala Met Thr Cys Ile Ala Ala Gly Ile Val Thr
Leu Tyr 755 760 765 Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val
Val Ser Trp Lys 770 775 780 Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile
Phe Ile Thr Asp Asn Val 785 790 795 800 His Thr Trp Thr Glu Gln Tyr
Lys Phe Gln Pro Glu Ser Pro Ser Lys 805 810 815 Leu Ala Ser Ala Ile
Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 820 825 830 Arg Ser Val
Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 835 840 845 Glu
Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 850 855
860 Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg
865 870 875 880 Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp
Gly Lys Ala 885 890 895 Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr
Phe Leu Ile Asp Gly 900 905 910 Pro Glu Thr Ala Glu Cys Pro Asn Thr
Asn Arg Ala Trp Asn Ser Leu 915 920 925 Glu Val Glu Asp Tyr Gly Phe
Gly Val Phe Thr Thr Asn Ile Trp Leu 930 935 940 Lys Leu Lys Glu Lys
Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 945 950 955 960 Ala Ala
Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 965 970 975
Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 980
985 990 Ile Glu Val Lys Asn Cys His Trp Pro Lys Ser His Thr Leu Trp
Ser 995 1000 1005 Asn Gly Val Leu Glu Ser Glu Met Ile Ile Pro Lys
Asn Leu Ala 1010 1015 1020 Gly Pro Val Ser Gln His Asn Tyr Arg Pro
Gly Tyr His Thr Gln 1025 1030 1035 Ile Thr Gly Pro Trp His Leu Gly
Lys Leu Glu Met Asp Phe Asp 1040 1045 1050 Phe Cys Asp Gly Thr Thr
Val Val Val Thr Glu Asp Cys Gly Asn 1055 1060 1065 Arg Gly Pro Ser
Leu Arg Thr Thr Thr Ala Ser Gly Lys Leu Ile 1070 1075 1080 Thr Glu
Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg Tyr 1085 1090 1095
Arg Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Leu 1100
1105 1110 Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala
Gly 1115 1120 1125 His Gly Gln Val Asp Asn Phe Ser Leu Gly Val Leu
Gly Met Ala 1130 1135 1140 Leu Phe Leu Glu Glu Met Leu Arg Thr Arg
Val Gly Thr Lys His 1145 1150 1155 Ala Ile Leu Leu Val Ala Val Ser
Phe Val Thr Leu Ile Thr Gly 1160 1165 1170 Asn Met Ser Phe Arg Asp
Leu Gly Arg Val Met Val Met Val Gly 1175 1180 1185 Ala Thr Met Thr
Gly Asp Ile Gly Met Gly Val Thr Tyr Leu Ala 1190 1195 1200 Leu Leu
Ala Ala Phe Lys Val Arg Pro Thr Phe Ala Ala Gly Leu 1205 1210 1215
Leu Leu Arg Lys Leu Thr Ser Arg Glu Leu Met Met Thr Thr Ile 1220
1225 1230 Gly Ile Val Leu Leu Ser Gln Ser Thr Ile Pro Glu Thr Ile
Leu 1235 1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly Met Met Val
Leu Lys Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr Gln Leu Ala
Val Thr Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro Asn Ala Val
Ile Leu Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys Thr Ile Leu
Ala Val Val Ser Val Ser Pro Leu Phe 1295 1300 1305 Leu Thr Ser Ser
Gln Gln Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315 1320 Thr Ile
Lys Gly Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu 1325 1330 1335
Ser Arg Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile 1340
1345 1350 Met Ala Val Gly Met Val Ser Ile Leu Ala Ser Ser Leu Leu
Lys 1355 1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu Val Ala Gly
Gly Leu Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr Gly Arg Ser
Ala Asp Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp Val Lys Trp
Glu Asp Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser Pro Ile Leu
Ser Ile Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met Ser Ile Lys
Asn Glu Glu Glu Glu Gln Thr Leu Thr Ile Leu 1430 1435 1440 Ile Arg
Thr Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser 1445 1450 1455
Ile Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys 1460
1465 1470 Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro Pro
Met 1475 1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala Tyr Arg Ile
Lys Gln Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln Ile Gly Ala
Gly Val Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr Met Trp His
Val Thr Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys Gly Lys Arg
Ile Glu Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys Asp Leu Ile
Ser Tyr Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555 1560 Trp Lys
Glu Gly Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly 1565 1570 1575
Lys Asn Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe Lys Thr 1580
1585 1590 Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp Phe Ser Pro
Gly 1595 1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly Lys
Val Val Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val Thr Arg Ser
Gly Ala Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr Glu Lys Ser
Ile Glu Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp Ile Phe Arg
Lys Arg Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His Pro Gly Ala
Gly Lys Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675 1680 Arg Glu
Ala Ile Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro 1685 1690 1695
Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu 1700
1705 1710 Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala Val His Thr
Gly 1715 1720 1725 Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe
Thr Met Arg 1730 1735 1740 Leu Leu Ser Pro Val Arg Val Pro Asn Tyr
Asn Leu Ile Ile Met 1745 1750 1755 Asp Glu Ala His Phe Thr Asp Pro
Ala Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser Thr Arg Val
Glu Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met Thr Ala Thr
Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795 1800 Asn Ala
Pro Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser 1805 1810 1815
Trp Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly Lys Thr 1820
1825 1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala
Ala 1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val Ile Gln Leu
Ser Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val Lys Thr Arg
Thr Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr Asp Ile Ser
Glu Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg Val Ile Asp
Pro Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu Thr Asp Gly
Glu Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915 1920 Val Thr
His Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg 1925 1930 1935
Asn Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly Glu Pro 1940
1945 1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys Glu Ala Lys
Met 1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile
Pro Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys Val Asp Ala
Ile Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu Ala Arg Lys
Thr Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp Leu Pro Val
Trp Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly Ile Asn Tyr
Ala Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035 2040 Asn Asn
Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr 2045 2050 2055
Lys Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala 2060
2065 2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu
Phe 2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu Asn Leu Ile
Thr Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met Thr Gln Lys
Val Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val Leu His Thr
Ala Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His Ala Leu Ser
Glu Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu Leu Leu Thr
Leu Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155 2160 Phe Leu
Met Ser Ala Arg Gly Ile Gly Lys Met Thr Leu Gly Met 2165 2170 2175
Cys Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala Gln Ile 2180
2185 2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu Glu Phe Phe
Leu 2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg
Thr Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val Val Ile Ala
Ile Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala Asn Glu Met
Gly Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu Gly Leu Gly
Ser Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn Ile Leu Asp
Ile Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275 2280 Tyr Ala
Val Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser 2285 2290 2295
Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile Ala Asn
2300
2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly Trp Pro Leu
Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu Ala Ile Gly
Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu Thr Ala Ala
Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile Ile Gly Pro
Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala Gln Lys Arg
Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr Val Asp Gly
Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395 2400 Asp Pro
Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val 2405 2410 2415
Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp Ala Leu 2420
2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile Ser Thr Leu
Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn Thr Thr Ile
Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly Ser Tyr Leu
Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met Lys Asn Thr
Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile Gly Glu Thr
Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn Ala Leu Gly
Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515 2520 Ile Gln
Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg 2525 2530 2535
Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala Lys Leu 2540
2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro Glu Gly Lys
Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr
Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu Val Lys Gly
Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu Pro Ile Pro
Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg Leu Gln Ser
Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu Lys Cys Asp
Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635 2640 Asn Pro
Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu 2645 2650 2655
Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile Lys Val 2660
2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys Met Glu Ala
Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val Arg Asn Pro
Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr Trp Val Ser
Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val Asn Met Ile
Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met Arg Tyr Lys
Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu Gly Ser Gly
Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755 2760 Asn Leu
Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu 2765 2770 2775
His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr Lys Thr 2780
2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly Ser
Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg Leu Leu Thr
Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr Gln Met Ala
Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln Arg Val Phe
Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu Pro Lys Glu
Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala Glu Trp Leu
Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875 2880 Met Cys
Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 2885 2890 2895
Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys Ser Ala 2900
2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu Leu Val Asp
Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys Cys Glu Thr
Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu Lys Lys Leu
Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg Ala Ile Trp
Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu Phe Glu Ala
Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe Ser Arg Glu
Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995 3000 His Lys
Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly 3005 3010 3015
Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile 3020
3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val Thr Asn His
Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu Ala Ile Phe
Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg Val Gln Arg
Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile Ile Ser Arg
Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly Thr Tyr Gly
Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln Leu Ile Arg
Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115 3120 Gln His
Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu 3125 3130 3135
Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile Ser Gly 3140
3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg Phe Ala Ser
Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys Ile Arg Lys
Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly Trp Asn Asp
Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His Phe His Glu
Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val Val Pro Cys
Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala Arg Ile Ser
Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235 3240 Cys Leu
Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe 3245 3250 3255
His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala 3260
3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr Thr Trp Ser
Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr Glu Asp Met
Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln Glu Asn Pro
Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser Trp Glu Glu
Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln Trp Cys Gly
Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr Trp Ala Lys
Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355 3360 Leu Ile
Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys 3365 3370 3375
Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp 3380 3385 3390
2210723DNAArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 4, DENV-4e 22agttgttagt ctacgtggac
cgacaaagac agattctttg agggagctaa gctcaatgta 60gttctaacag ttttttaatt
agagagcaga tctctgatga ataaccaacg gaaaaaggcg 120aaaaacacgc
ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag
180ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa
actgttcatg 240gccctggtgg cgttccttcg tttcctaaca atcccaccaa
cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc aaaagctatt
aatgttttga gagggttcag gaaagagatt 360ggaaggatgc tgaacatctt
gaataggaga cgcagctcaa cgataacatt gctgtacttg 420attcccaccg
taatggcgtt tcacttgtca acgcgtgatg gcgaacccct catgatagtg
480gcaaaacatg aaagggggag acctctcttg tttaagacaa cagaggggat
caacaaatgc 540actctcattg ccatggactt gggtgaaatg tgtgaggaca
ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc tgaagacatt
gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg ggacatgcac
ccagagcgga gaacggagac gagagaagcg ctcagtagct 720ttaacaccac
attcaggaat gggattggaa acaagagctg agacatggat gtcatcggaa
780ggggcttgga agcatgctca gagagtagag agctggatac tcagaaaccc
aggattcgcg 840ctcttggcag gatttatggc ttatatgatt gggcaaacag
gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt cgccccatcc
tacggaatgc gatgcgtagg agtaggaaac 960agagactttg tggaaggagt
ctcaggtgga gcatgggtcg atctggtgct agaacatgga 1020ggatgcgtca
caaccatggc ccagggaaaa ccaaccttgg attttgaact gactaagaca
1080acagccaagg aagtggctct gttaagaacc tattgcattg aagcctcaat
atcaaacata 1140accacggcaa caagatgtcc aacgcaagga gagccttatc
taaaagagga acaagaccaa 1200cagtacattt gccggagaga tgtggtagac
agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag gagttgtgac
atgtgcgaag ttttcatgtt cggggaagat aacaggcaat 1320ttggtccaaa
ttgagaacct tgaatacaca gtggttgtaa cagtccacaa tggagacacc
1380catgcagtag gaaatgacac gtccaatcat ggagttacag ccacgataac
tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat ggagaactaa
cactcgattg tgaacccagg 1500tctggaattg actttaatga gatgattctg
atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat ggtttttgga
tctacctcta ccatggacag caggagcaga cacatcagag 1620gttcactgga
attacaaaga gagaatggtg acatttaagg ttcctcatgc caagagacag
1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt ctgccctcgc
tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg tttgcaggac
atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa gggaatgtca
tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga tggcagaaac
acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt 1920gctggagctc
cgtgtaaagt ccccatagag ataagagatg tgaacaagga aaaagtggtt
1980gggcgtatca tctcatccac ccctttggct gagaatacca acagtgtaac
caacatagag 2040ttagaacccc cctttgggga cagctacata gtgataggtg
ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg gagttccatt
ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa tggccattct
aggtgaaaca gcttgggatt ttggttccgt tggtggactg 2220ttcacatcat
tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac aaccctgttt
2280ggaggagtct catggatgat tagaatccta attgggttcc tagtgttgtg
gattggcacg 2340aactcaagga acacttcaat ggctatgacg tgcatagctg
ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc cgatagtggt
tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca gtgggatttt
catcacagac aacgtgcaca catggacaga acaatacaag 2520ttccaaccag
aatccccttc aaaactagct tcagctatcc agaaagccca tgaagaggac
2580atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca
aataacacca 2640gaattgaatc acattctatc agaaaatgag gtgaagttaa
ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg aaaacgatct
ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa catggggcaa
agcaaaaatg ctctctacag agtctcataa ccagaccttt 2820ctcattgatg
gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg
2880gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa
attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc atgtcagcgg
ccataaaaga caacagagcc 3000gtccatgccg atatgggtta ttggatagaa
agtgcactca atgacacatg gaagatagag 3060aaagcctctt tcattgaagt
taaaaactgc cactggccaa aatcacacac cctctggagc 3120aatggagtgc
tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa
3180cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct
aggtaagctt 3240gagatggact ttgatttctg tgatggaaca acagtggtag
tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac aaccactgcc
tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca cattaccacc
gctaagatac agaggtgagg atgggtgctg gtacgggatg 3420gaaatcagac
cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga
3480catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt
cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat gcaatactac
tagttgcagt ttcttttgtg 3600acattgatca cagggaacat gtcctttaga
gacctgggaa gagtgatggt tatggtaggc 3660gccactatga cggatgacat
aggtatgggc gtgacttatc ttgccctact agcagccttc 3720aaagtcagac
caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg
3780atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga
gaccattctt 3840gagttgactg atgcgttagc cttaggcatg atggtcctca
aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac tatcatggct
atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat ggaaagtgag
ttgcacaata ttggcagtgg tgtccgtttc cccactgttc 4020ttaacatcct
cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc
4080aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag
gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg gtgagcattt
tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg accattagtg
gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac gatcggccga
tttggaactg gagagagcag ccgatgtcaa atgggaagac 4320caggcagaga
tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc
4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag
aacaggattg 4440ctggtgatct caggactttt tcctgtatca ataccaatca
cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg ggccggagta
ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg aactggaaga
tggagcctat agaattaagc aaaaagggat tcttggatat 4620tcccagatcg
gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca
4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc
ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg aagttagaag
gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact ggagcctgga
aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca aaaccaacgc
cggaacaata ggtgctgtat ctctggactt ttctcctgga 4920acgtcaggat
ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt
4980gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa
aagcattgaa 5040gacaacccag agatcgaaga tgacattttc cgaaagagaa
gactgaccat catggacctc 5100cacccaggag cgggaaagac gaagagatac
cttccggcca tagtcagaga agctataaaa 5160cggggtttga gaacattaat
cttggccccc actagagttg tggcagctga aatggaggaa 5220gcccttagag
gacttccaat aagataccag accccagcca tcagagctgt gcacaccggg
5280cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct
atcaccagtt 5340agagtgccaa actacaacct gattatcatg gacgaagccc
atttcacaga cccagcaagt 5400atagcagcta gaggatacat ctcaactcga
gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca ctcccccggg
aagcagagac ccatttcctc agagcaatgc accaatcata 5520gatgaagaaa
gagaaatccc tgaacgctcg tggaattccg gacatgaatg ggtcacggat
5580tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga
tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata caactcagta
ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa tgattgggac
ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt tcaaggctga
gagggttata gaccccagac gctgcatgaa accagtcata 5820ctaacagatg
gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt
5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga
ccagtacata 5940tacatggggg aacctctgga aaatgatgaa gactgtgcac
actggaaaga agctaaaatg 6000ctcctagata acatcaacac gccagaagga
atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg atgccattga
tggcgaatac cgcttgagag gagaagcaag gaaaaccttt 6120gtagacttaa
tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa
6180ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa
ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca aaagaagggg
aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat ctattctgac
ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa gaaagtctct
gaccctgaac ctaatcacag aaatgggtag gctcccaacc 6420ttcatgactc
agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag
6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct
ggagacattg 6540cttttactga cacttctggc tacagtcacg ggagggatct
ttttattctt gatgagcgca 6600aggggcatag ggaagatgac cctgggaatg
tgctgcataa tcacggctag catcctccta 6660tggtacgcac aaatacagcc
acactggata gcagcttcaa taatactgga gttttttctc 6720atagttttgc
ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc
6780tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga
gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg
caacccagca acccgagagc 6900aacatcctgg acatagatct acgtcctgca
tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta caccaatgtt
gagacatagc attgaaaatt cctcagtgaa tgtgtcccta 7020acagctatag
ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca
7080aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt
caaccccata 7140actctcacag cagctctttt cttattggta gcacattatg
ccatcatagg gccaggactc 7200caagcaaaag caaccagaga agctcagaaa
agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg gaataacagt
gattgaccta gatccaatac cttatgatcc aaagtttgaa 7320aagcagttgg
gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg
7380actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc
cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact accattgcgg
tgtcaatggc taacattttt 7500agagggagtt acttggccgg agctggactt
ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg gaactggcaa
cataggagag acgcttggag agaaatggaa aagccgattg 7620aacgcattgg
gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat
7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc
tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag agaaacatgg
tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag aggaggctgg
tcatactatt gtggaggact aaagaatgta 7860agagaagtca aaggcctaac
aaaaggagga ccaggacacg aagaacccat ccccatgtca 7920acatatgggt
ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca
7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc
cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta gtagaaaatt
ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa cccatatatg
ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat atggaggagc
cttagtgagg aatccactct cacgaaactc cacacatgag 8220atgtactggg
tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg
8280atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc
ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga
taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat aaagcaagag
catgaaacat catggcacta tgaccaagac 8460cacccataca aaacgtgggc
ataccatggt agctatgaaa caaaacagac tggatcagca 8520tcatccatgg
tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg
8580gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt
ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa gaaggcacga
agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga attagggaag
aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa gaaaggtgag
aagcaatgca gccttggggg ccatattcac tgatgagaac 8820aagtggaagt
cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag
8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat
gatgggaaaa 8940agagagaaga agctagggga attcggcaag gcaaaaggca
gcagagccat atggtacatg 9000tggcttggag cacgcttctt agagtttgaa
gccctaggat tcttaaatga agatcactgg 9060ttctccagag agaactccct
gagtggagtg gaaggagaag ggctgcacaa gctaggttac 9120attctaagag
acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga
9180tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac
aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc attttcaaac
taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac accaagaggc
acagtaatgg acatcatatc gagaagagac 9360caaagaggta gtggacaagt
tggcacctat ggactcaata ctttcaccaa tatggaagcc 9420caactaatca
gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc
9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag
gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg aaacctttag
atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat gggaaagatt
aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga atgattggac
acaagtgccc ttctgttcac accatttcca tgagttaatc 9720atgaaagacg
gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga
9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt
ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc cacagacgcg
acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc atcacattgg
gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac atgaatggat
gacaacggaa gacatgctga cagtctggaa cagggtgtgg 10020attcaagaaa
acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca
10080tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac
aagcagggcc 10140acctgggcaa agaacatcca agcagcaata aatcaagtta
gatcccttat aggcaatgaa 10200gaatacacag attacatgcc atccatgaaa
agattcagaa gagaagagga agaagcagga 10260gttctgtggt agaaagcaaa
actaacatga aacaaggcta gaagtcaggt cggattaagc 10320catagtacgg
aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca
10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca
cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac
gcatggcgta gtggactagc 10500ggttagagga gacccctccc ttacaaatcg
cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc tcgctggaag
gactagaggt tagaggagac ccccccgaaa caaaaaacag 10620catattgacg
ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca
10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct
10723233391PRTArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 4, DEN-4e 23Met Asn Asn Gln Arg Lys Lys Ala
Lys Asn Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg
Val Ser Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly
Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu
Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60
Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65
70 75 80 Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile
Leu Asn 85 90 95 Arg Arg Arg Ser Ser Thr Ile Thr Leu Leu Tyr Leu
Ile Pro Thr Val 100 105 110 Met Ala Phe His Leu Ser Thr Arg Asp Gly
Glu Pro Leu Met Ile Val 115 120 125 Ala Lys His Glu Arg Gly Arg Pro
Leu Leu Phe Lys Thr Thr Glu Gly 130 135 140 Ile Asn Lys Cys Thr Leu
Ile Ala Met Asp Leu Gly Glu Met Cys Glu 145 150 155 160 Asp Thr Val
Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu 165 170 175 Asp
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly 180 185
190 Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala
195 200 205 Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu
Thr Trp 210 215 220 Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg
Val Glu Ser Trp 225 230 235 240 Ile Leu Arg Asn Pro Gly Phe Ala Leu
Leu Ala Gly Phe Met Ala Tyr 245 250 255 Met Ile Gly Gln Thr Gly Ile
Gln Arg Thr Val Phe Phe Val Leu Met 260 265 270 Met Leu Val Ala Pro
Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn 275 280 285 Arg Asp Phe
Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val 290 295 300 Leu
Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr 305 310
315 320 Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu
Leu 325 330 335 Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr
Thr Ala Thr 340 345 350 Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys
Glu Glu Gln Asp Gln 355 360 365 Gln Tyr Ile Cys Arg Arg Asp Val Val
Asp Arg Gly Trp Gly Asn Gly 370 375 380 Cys Gly Leu Phe Gly Lys Gly
Gly Val Val Thr Cys Ala Lys Phe Ser 385 390 395 400 Cys Ser Gly Lys
Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu 405 410 415 Tyr Thr
Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly 420 425 430
Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser 435
440 445 Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu
Asp 450 455 460 Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile
Leu Met Lys 465 470 475 480 Met Lys Lys Lys Thr Trp Leu Val His Lys
Gln Trp Phe Leu Asp Leu 485 490 495 Pro Leu Pro Trp Thr Ala Gly Ala
Asp Thr Ser Glu Val His Trp Asn 500 505 510 Tyr Lys Glu Arg Met Val
Thr Phe Lys Val Pro His Ala Lys Arg Gln 515 520 525 Asp Val Thr Val
Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu 530 535 540 Ala Gly
Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala 545 550 555
560 Gly His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly
565 570 575 Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys
Glu Met 580 585 590 Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val
Lys Tyr Glu Gly 595 600 605 Ala Gly Ala Pro Cys Lys Val Pro Ile Glu
Ile Arg Asp Val Asn Lys 610 615 620 Glu Lys Val Val Gly Arg Ile Ile
Ser Ser Thr Pro Leu Ala Glu Asn 625 630 635 640 Thr Asn Ser Val Thr
Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 645 650 655 Tyr Ile Val
Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe 660 665 670 Arg
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly 675 680
685 Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser
690 695 700 Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln
Val Phe 705 710 715 720 Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val
Ser Trp Met Ile Arg 725 730 735 Ile Leu Ile Gly Phe Leu Val Leu Trp
Ile Gly Thr Asn Ser Arg Asn 740 745 750 Thr Ser Met Ala Met Thr Cys
Ile Ala Ala Gly Ile Val Thr Leu Tyr 755 760 765 Leu Gly Val Met Val
Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 770 775 780 Asn Lys Glu
Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 785 790 795 800
His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 805
810 815 Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly
Ile 820 825 830 Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln
Ile Thr Pro 835 840 845 Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val
Lys Leu Thr Ile Met 850 855 860 Thr Gly Asp Ile Lys Gly Ile Met Gln
Ala Gly Lys Arg Ser Leu Arg 865 870 875 880 Pro Gln Pro Thr Glu Leu
Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 885 890 895 Lys Met Leu Ser
Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 900 905 910 Pro Glu
Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 915 920 925
Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 930
935 940 Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met
Ser 945 950 955 960 Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp
Met Gly Tyr Trp 965 970 975 Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys
Ile Glu Lys Ala Ser Phe 980 985 990 Ile Glu Val Lys Asn Cys His Trp
Pro Lys Ser His Thr Leu Trp Ser 995 1000 1005 Asn Gly Val Leu Glu
Ser Glu Met Ile Ile Pro Lys Asn Leu Ala 1010 1015 1020 Gly Pro Val
Ser Gln His Asn Tyr Arg Pro Gly Tyr His Thr Gln 1025 1030 1035 Ile
Thr Gly Pro Trp His Leu Gly Lys Leu Glu Met Asp Phe Asp 1040 1045
1050 Phe Cys Asp Gly Thr Thr Val Val Val Thr Glu Asp Cys Gly Asn
1055 1060 1065 Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser Gly Lys
Leu Ile 1070 1075 1080 Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro
Pro Leu Arg Tyr 1085 1090 1095 Arg Gly Glu Asp Gly Cys Trp Tyr Gly
Met Glu Ile Arg Pro Leu 1100 1105 1110 Lys Glu Lys Glu Glu Asn Leu
Val Asn Ser Leu Val Thr Ala Gly 1115 1120 1125 His Gly Gln Val Asp
Asn Phe Ser Leu Gly Val Leu Gly Met Ala 1130 1135 1140 Leu Phe Leu
Glu Glu Met Leu Arg Thr Arg Val Gly Thr Lys His 1145 1150 1155 Ala
Ile Leu Leu Val Ala Val Ser Phe Val Thr Leu Ile Thr Gly 1160 1165
1170 Asn Met Ser Phe Arg Asp Leu Gly Arg Val Met Val Met Val Gly
1175 1180 1185 Ala Thr Met Thr Asp Asp Ile Gly Met Gly Val Thr Tyr
Leu Ala 1190 1195 1200 Leu Leu Ala Ala Phe Lys Val Arg Pro Thr Phe
Ala Ala Gly Leu 1205 1210 1215 Leu Leu Arg Lys Leu Thr Ser Lys Glu
Leu Met Met Thr Thr Ile 1220 1225 1230 Gly Ile Val Leu Leu Ser Gln
Ser Thr Ile Pro Glu Thr Ile Leu 1235 1240 1245 Glu Leu Thr Asp Ala
Leu Ala Leu Gly Met Met Val Leu Lys Met 1250 1255 1260 Val Arg Asn
Met Glu Lys Tyr Gln Leu Ala Val Thr Ile Met Ala 1265 1270 1275 Ile
Leu Cys Val Pro Asn Ala Val Ile Leu Gln Asn Ala Trp Lys 1280 1285
1290 Val Ser Cys Thr Ile Leu Ala Val Val Ser Val Ser Pro Leu Phe
1295 1300 1305 Leu Thr Ser Ser Gln Gln Lys Thr Asp Trp Ile Pro Leu
Ala Leu 1310 1315 1320 Thr Ile Lys Gly Leu Asn Pro Thr Ala Ile Phe
Leu Thr Thr Leu 1325 1330 1335 Ser Arg Thr Ser Lys Lys Arg Ser Trp
Pro Leu Asn Glu Ala Ile 1340 1345 1350 Met Ala Val Gly Met Val Ser
Ile Leu Ala Ser Ser Leu Leu Lys 1355 1360 1365 Asn Asp Ile Pro Met
Thr Gly Pro Leu Val Ala Gly Gly Leu Leu 1370 1375 1380 Thr Val Cys
Tyr Val Leu Thr Gly Arg Ser Ala Asp Leu Glu Leu 1385 1390 1395 Glu
Arg Ala Ala Asp Val Lys Trp Glu Asp Gln Ala Glu Ile Ser 1400 1405
1410 Gly Ser Ser Pro Ile Leu Ser Ile Thr Ile Ser Glu Asp Gly Ser
1415 1420 1425 Met Ser Ile Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr
Ile Leu 1430 1435 1440 Ile Arg Thr Gly Leu Leu Val Ile Ser Gly Leu
Phe Pro Val Ser 1445 1450 1455 Ile Pro Ile Thr Ala Ala Ala Trp Tyr
Leu Trp Glu Val Lys Lys 1460 1465 1470 Gln Arg Ala Gly Val Leu Trp
Asp Val Pro Ser Pro Pro Pro Met 1475 1480 1485 Gly Lys Ala Glu Leu
Glu Asp Gly Ala Tyr Arg Ile Lys Gln Lys 1490 1495 1500 Gly Ile Leu
Gly Tyr Ser Gln Ile Gly Ala Gly Val Tyr Lys Glu 1505 1510 1515 Gly
Thr Phe His Thr Met Trp His Val Thr Arg Gly Ala Val Leu 1520 1525
1530 Met His Lys Gly Lys Arg Ile Glu Pro Ser Trp Ala Asp Val Lys
1535 1540 1545 Lys Asp Leu Ile Ser Tyr Gly Gly Gly Trp Lys Leu Glu
Gly Glu 1550 1555 1560 Trp Lys Glu Gly Glu Glu Val Gln Val Leu Ala
Leu Glu Pro Gly 1565 1570 1575 Lys Asn Pro Arg Ala Val Gln Thr Lys
Pro Gly Leu Phe Lys Thr 1580 1585 1590 Asn Ala Gly Thr Ile Gly Ala
Val Ser Leu Asp Phe Ser Pro Gly 1595 1600 1605 Thr Ser Gly Ser Pro
Ile Ile Asp Lys Lys Gly Lys Val Val Gly 1610 1615 1620 Leu Tyr Gly
Asn Gly Val Val Thr Arg Ser Gly Ala Tyr Val Ser 1625 1630 1635 Ala
Ile Ala Gln Thr Glu Lys Ser Ile Glu Asp Asn Pro Glu Ile 1640 1645
1650 Glu Asp Asp Ile Phe Arg Lys Arg Arg Leu Thr Ile Met Asp Leu
1655 1660 1665 His Pro Gly Ala Gly Lys Thr Lys Arg Tyr Leu Pro Ala
Ile Val 1670 1675 1680 Arg Glu Ala Ile Lys Arg Gly Leu Arg Thr Leu
Ile Leu Ala Pro 1685 1690 1695 Thr Arg Val Val Ala Ala Glu Met Glu
Glu Ala Leu Arg Gly Leu 1700 1705 1710 Pro Ile Arg Tyr Gln Thr Pro
Ala Ile Arg Ala Val His Thr Gly 1715 1720 1725 Arg Glu Ile Val Asp
Leu Met Cys His Ala Thr Phe Thr Met Arg 1730 1735 1740 Leu Leu Ser
Pro Val Arg Val Pro Asn Tyr Asn Leu Ile Ile Met 1745 1750 1755 Asp
Glu Ala His Phe
Thr Asp Pro Ala Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser
Thr Arg Val Glu Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met
Thr Ala Thr Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795
1800 Asn Ala Pro Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser
1805 1810 1815 Trp Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly
Lys Thr 1820 1825 1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn
Asp Ile Ala Ala 1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val
Ile Gln Leu Ser Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val
Lys Thr Arg Thr Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr
Asp Ile Ser Glu Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg
Val Ile Asp Pro Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu
Thr Asp Gly Glu Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915
1920 Val Thr His Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg
1925 1930 1935 Asn Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly
Glu Pro 1940 1945 1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys
Glu Ala Lys Met 1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu
Gly Ile Ile Pro Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys
Val Asp Ala Ile Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu
Ala Arg Lys Thr Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp
Leu Pro Val Trp Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly
Ile Asn Tyr Ala Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035
2040 Asn Asn Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr
2045 2050 2055 Lys Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu
Asp Ala 2060 2065 2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu
Phe Lys Glu Phe 2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu
Asn Leu Ile Thr Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met
Thr Gln Lys Ala Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val
Leu His Thr Ala Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His
Ala Leu Ser Glu Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu
Leu Leu Thr Leu Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155
2160 Phe Leu Met Ser Ala Arg Gly Ile Gly Lys Met Thr Leu Gly Met
2165 2170 2175 Cys Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala
Gln Ile 2180 2185 2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu
Glu Phe Phe Leu 2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu
Lys Gln Arg Thr Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val
Val Ile Ala Ile Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala
Asn Glu Met Gly Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu
Gly Leu Gly Ser Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn
Ile Leu Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275
2280 Tyr Ala Val Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser
2285 2290 2295 Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile
Ala Asn 2300 2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly
Trp Pro Leu Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu
Ala Ile Gly Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu
Thr Ala Ala Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile
Ile Gly Pro Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala
Gln Lys Arg Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr
Val Asp Gly Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395
2400 Asp Pro Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val
2405 2410 2415 Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp
Ala Leu 2420 2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile
Ser Thr Leu Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn
Thr Thr Ile Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly
Ser Tyr Leu Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met
Lys Asn Thr Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile
Gly Glu Thr Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn
Ala Leu Gly Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515
2520 Ile Gln Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg
2525 2530 2535 Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala
Lys Leu 2540 2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro
Glu Gly Lys Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly
Trp Ser Tyr Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu
Val Lys Gly Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu
Pro Ile Pro Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg
Leu Gln Ser Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu
Lys Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635
2640 Asn Pro Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu
2645 2650 2655 Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile
Lys Val 2660 2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys
Met Glu Ala Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val
Arg Asn Pro Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr
Trp Val Ser Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val
Asn Met Ile Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met
Arg Tyr Lys Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu
Gly Ser Gly Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755
2760 Asn Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu
2765 2770 2775 His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr
Lys Thr 2780 2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln
Thr Gly Ser Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg
Leu Leu Thr Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr
Gln Met Ala Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln
Arg Val Phe Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu
Pro Lys Glu Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala
Glu Trp Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875
2880 Met Cys Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala
2885 2890 2895 Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys
Ser Ala 2900 2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu
Leu Val Asp Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys
Cys Glu Thr Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu
Lys Lys Leu Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg
Ala Ile Trp Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu
Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe
Ser Arg Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995
3000 His Lys Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly
3005 3010 3015 Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr
Arg Ile 3020 3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val
Thr Asn His Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu
Ala Ile Phe Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg
Val Gln Arg Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile
Ile Ser Arg Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly
Thr Tyr Gly Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln
Leu Ile Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115
3120 Gln His Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu
3125 3130 3135 Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile
Ser Gly 3140 3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg
Phe Ala Ser Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys
Ile Arg Lys Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly
Trp Asn Asp Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His
Phe His Glu Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val
Val Pro Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala
Arg Ile Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235
3240 Cys Leu Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe
3245 3250 3255 His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys
Ser Ala 3260 3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr
Thr Trp Ser Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr
Glu Asp Met Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln
Glu Asn Pro Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser
Trp Glu Glu Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln
Trp Cys Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr
Trp Ala Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355
3360 Leu Ile Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys
3365 3370 3375 Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp
3380 3385 3390 2410723DNAArtificial SequenceDerived from Dengue
virus serotype 2/Dengue virus serotype 4, DEN, 4h 24agttgttagt
ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta 60gttctaacag
ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtaaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg
aaaacgatct ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa
catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt
2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg
gaattcgttg 2880gaagttgaag actatggctt tggagtattc accaccaata
tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc
atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg atatgggtta
ttggatagaa agtgcactca atgacacatg gaagatagag 3060aaagcctctt
tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc
3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc
agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa ataacaggac
catggcatct aggtaagctt 3240gagatggact ttgatttctg tgatggaaca
acagtggtag tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac
aaccactgcc tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca
cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg
3420gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt
cacagctgga 3480catgggcagg tcgacaactt ttcactagga gtcttgggaa
tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat
gcaatactac tagttgcagt ttcttttgtg 3600acattgatca cagggaacat
gtcctttaga gacctgggaa gagtgatggt tatggtaggc 3660gccactatga
cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
caaggaattg
3780atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga
gaccattctt 3840gagttgactg atgcgttagc cttaggcatg atggtcctca
aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac tatcatggct
atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat ggaaagtgag
ttgcacaata ttggcagtgg tgtccgtttc cccactgttc 4020ttaacatcct
cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc
4080aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag
gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg gtgagcattt
tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg accattagtg
gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac gatcggccga
tttggaactg gagagagcag ccgatgtcaa atgggaagac 4320caggcagaga
tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc
4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag
aacaggattg 4440ctggtgatct caggactttt tcctgtatca ataccaatca
cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg ggccggagta
ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg aactggaaga
tggagcctat agaattaagc aaaaagggat tcttggatat 4620tcccagatcg
gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca
4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc
ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg aagttagaag
gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact ggagcctgga
aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca aaaccaacgc
cggaacaata ggtgctgtat ctctggactt ttctcctgga 4920acgtcaggat
ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt
4980gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa
aagcattgaa 5040gacaacccag agatcgaaga tgacattttc cgaaagagaa
gactgaccat catggacctc 5100cacccaggag cgggaaagac gaagagatac
cttccggcca tagtcagaga agctataaaa 5160cggggtttga gaacattaat
cttggccccc actagagttg tggcagctga aatggaggaa 5220gcccttagag
gacttccaat aagataccag accccagcca tcagagctgt gcacaccggg
5280cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct
atcaccagtt 5340agagtgccaa actacaacct gattatcatg gacgaagccc
atttcacaga cccagcaagt 5400atagcagcta gaggatacat ctcaactcga
gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca ctcccccggg
aagcagagac ccatttcctc agagcaatgc accaatcata 5520gatgaagaaa
gagaaatccc tgaacgctcg tggaattccg gacatgaatg ggtcacggat
5580tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga
tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata caactcagta
ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa tgattgggac
ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt tcaaggctga
gagggttata gaccccagac gctgcatgaa accagtcata 5820ctaacagatg
gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt
5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga
ccagtacata 5940tacatggggg aacctctgga aaatgatgaa gactgtgcac
actggaaaga agctaaaatg 6000ctcctagata acatcaacac gccagaagga
atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg atgccattga
tggcgaatac cgcttgagag gagaagcaag gaaaaccttt 6120gtagacttaa
tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa
6180ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa
ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca aaagaagggg
aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat ctattctgac
ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa gaaagtctct
gaccctgaac ctaatcacag aaatgggtag gctcccaacc 6420ttcatgactc
agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag
6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct
ggagacattg 6540cttttactga cacttctggc tacagtcacg ggagggatct
ttttattctt gatgagcgca 6600aggggcatag ggaagatgac cctgggaatg
tgctgcataa tcacggctag catcctccta 6660tggtacgcac aaatacagcc
acactggata gcagcttcaa taatactgga gttttttctc 6720atagttttgc
ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc
6780tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga
gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg
caacccagca acccgagagc 6900aacatcctgg acatagatct acgtcctgca
tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta caccaatgtt
gagacatagc attgaaaatt cctcagtgaa tgtgtcccta 7020acagctatag
ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca
7080aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt
caaccccata 7140actctcacag cagctctttt cttattggta gcacattatg
ccatcatagg gccaggactc 7200caagcaaaag caaccagaga agctcagaaa
agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg gaataacagt
gattgaccta gatccaatac cttatgatcc aaagtttgaa 7320aagcagttgg
gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg
7380actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc
cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact accattgcgg
tgtcaatggc taacattttt 7500agagggagtt acttggccgg agctggactt
ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg gaactggcaa
cataggagag acgcttggag agaaatggaa aagccgattg 7620aacgcattgg
gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat
7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc
tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag agaaacatgg
tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag aggaggctgg
tcatactatt gtggaggact aaagaatgta 7860agagaagtca aaggcctaac
aaaaggagga ccaggacacg aagaacccat ccccatgtca 7920acatatgggt
ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca
7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc
cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta gtagaaaatt
ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa cccatatatg
ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat atggaggagc
cttagtgagg aatccactct cacgaaactc cacacatgag 8220atgtactggg
tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg
8280atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc
ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga
taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat aaagcaagag
catgaaacat catggcacta tgaccaagac 8460cacccataca aaacgtgggc
ataccatggt agctatgaaa caaaacagac tggatcagca 8520tcatccatgg
tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg
8580gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt
ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa gaaggcacga
agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga attagggaag
aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa gaaaggtgag
aagcaatgca gccttggggg ccatattcac tgatgagaac 8820aagtggaagt
cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag
8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat
gatgggaaaa 8940agagagaaga agctagggga attcggcaag gcaaaaggca
gcagagccat atggtacatg 9000tggcttggag cacgcttctt agagtttgaa
gccctaggat tcttaaatga agatcactgg 9060ttctccagag agaactccct
gagtggagtg gaaggagaag ggctgcacaa gctaggttac 9120attctaagag
acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga
9180tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac
aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc attttcaaac
taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac accaagaggc
acagtaatgg acatcatatc gagaagagac 9360caaagaggta gtggacaagt
tggcacctat ggactcaata ctttcaccaa tatggaagcc 9420caactaatca
gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc
9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag
gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg aaacctttag
atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat gggaaagatt
aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga atgattggac
acaagtgccc ttctgttcac accatttcca tgagttaatc 9720atgaaagacg
gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga
9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt
ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc cacagacgcg
acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc atcacattgg
gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac atgaatggat
gacaacggaa gacatgctga cagtctggaa cagggtgtgg 10020attcaagaaa
acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca
10080tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac
aagcagggcc 10140acctgggcaa agaacatcca agcagcaata aatcaagtta
gatcccttat aggcaatgaa 10200gaatacacag attacatgcc atccatgaaa
agattcagaa gagaagagga agaagcagga 10260gttctgtggt agaaagcaaa
actaacatga aacaaggcta gaagtcaggt cggattaagc 10320catagtacgg
aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca
10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca
cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac
gcatggcgta gtggactagc 10500ggttagagga gacccctccc ttacaaatcg
cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc tcgctggaag
gactagaggt tagaggagac ccccccgaaa caaaaaacag 10620catattgacg
ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca
10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct
10723253391PRTArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 4, DEN4h 25Met Asn Asn Gln Arg Lys Lys Ala
Lys Asn Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg
Val Ser Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly
Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu
Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60
Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65
70 75 80 Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile
Leu Asn 85 90 95 Arg Arg Arg Ser Ser Ala Gly Met Ile Ile Met Leu
Ile Pro Thr Val 100 105 110 Met Ala Phe His Leu Thr Thr Arg Asp Gly
Glu Pro Leu Met Ile Val 115 120 125 Ala Lys His Glu Arg Gly Arg Pro
Leu Leu Phe Lys Thr Thr Glu Gly 130 135 140 Ile Asn Lys Cys Thr Leu
Ile Ala Met Asp Leu Gly Glu Met Cys Glu 145 150 155 160 Asp Thr Val
Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu 165 170 175 Asp
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly 180 185
190 Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala
195 200 205 Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu
Thr Trp 210 215 220 Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg
Val Glu Ser Trp 225 230 235 240 Ile Leu Arg Asn Pro Gly Phe Ala Leu
Leu Ala Gly Phe Met Ala Tyr 245 250 255 Met Ile Gly Gln Thr Gly Ile
Gln Arg Thr Val Phe Phe Val Leu Met 260 265 270 Met Leu Val Ala Pro
Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn 275 280 285 Arg Asp Phe
Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val 290 295 300 Leu
Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr 305 310
315 320 Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu
Leu 325 330 335 Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr
Thr Ala Thr 340 345 350 Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys
Glu Glu Gln Asp Gln 355 360 365 Gln Tyr Ile Cys Arg Arg Asp Val Val
Asp Arg Gly Trp Gly Asn Gly 370 375 380 Cys Gly Leu Phe Gly Lys Gly
Gly Val Val Thr Cys Ala Lys Phe Ser 385 390 395 400 Cys Ser Gly Lys
Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu 405 410 415 Tyr Thr
Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly 420 425 430
Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser 435
440 445 Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu
Asp 450 455 460 Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile
Leu Met Lys 465 470 475 480 Met Lys Lys Lys Thr Trp Leu Val His Lys
Gln Trp Phe Leu Asp Leu 485 490 495 Pro Leu Pro Trp Thr Ala Gly Ala
Asp Thr Ser Glu Val His Trp Asn 500 505 510 Tyr Lys Glu Arg Met Val
Thr Phe Lys Val Pro His Ala Lys Arg Gln 515 520 525 Asp Val Thr Val
Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu 530 535 540 Ala Gly
Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala 545 550 555
560 Gly His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly
565 570 575 Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys
Glu Met 580 585 590 Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val
Lys Tyr Glu Gly 595 600 605 Ala Gly Ala Pro Cys Lys Val Pro Ile Glu
Ile Arg Asp Val Asn Lys 610 615 620 Glu Lys Val Val Gly Arg Ile Ile
Ser Ser Thr Pro Leu Ala Glu Asn 625 630 635 640 Thr Asn Ser Val Thr
Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 645 650 655 Tyr Ile Val
Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe 660 665 670 Arg
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly 675 680
685 Ala Lys Arg Met Ala Ile Leu Gly Lys Thr Ala Trp Asp Phe Gly Ser
690 695 700 Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln
Val Phe 705 710 715 720 Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val
Ser Trp Met Ile Arg 725 730 735 Ile Leu Ile Gly Phe Leu Val Leu Trp
Ile Gly Thr Asn Ser Arg Asn 740 745 750 Thr Ser Met Ala Met Thr Cys
Ile Ala Ala Gly Ile Val Thr Leu Tyr 755 760 765 Leu Gly Val Met Val
Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 770 775 780 Asn Lys Glu
Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 785 790 795 800
His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 805
810 815 Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly
Ile 820 825 830 Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln
Ile Thr Pro 835 840 845 Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val
Lys Leu Thr Ile Met 850 855 860 Thr Gly Asp Ile Lys Gly Ile Met Gln
Ala Gly Lys Arg Ser Leu Arg 865 870 875 880 Pro Gln Pro Thr Glu Leu
Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 885 890 895 Lys Met Leu Ser
Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 900 905 910 Pro Glu
Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 915 920 925
Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 930
935 940 Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met
Ser 945 950 955 960 Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp
Met Gly Tyr Trp 965 970 975 Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys
Ile Glu Lys Ala Ser Phe 980 985 990 Ile Glu Val Lys Asn Cys His Trp
Pro Lys Ser His Thr Leu Trp Ser 995 1000 1005 Asn Gly Val Leu Glu
Ser Glu Met Ile Ile Pro Lys Asn Leu Ala 1010 1015 1020 Gly Pro Val
Ser Gln His Asn Tyr Arg Pro Gly Tyr His Thr Gln 1025 1030 1035 Ile
Thr Gly Pro Trp His Leu Gly Lys Leu Glu Met Asp Phe Asp 1040 1045
1050 Phe Cys Asp Gly Thr Thr Val Val Val Thr Glu Asp Cys Gly Asn
1055 1060 1065 Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser Gly Lys
Leu Ile 1070 1075 1080 Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro
Pro Leu Arg Tyr 1085 1090 1095 Arg Gly Glu Asp Gly Cys Trp Tyr Gly
Met Glu Ile Arg Pro Leu 1100 1105 1110 Lys Glu Lys Glu Glu Asn Leu
Val Asn Ser Leu Val Thr Ala Gly 1115 1120 1125 His Gly Gln Val Asp
Asn Phe Ser Leu Gly Val Leu Gly Met Ala 1130 1135 1140 Leu Phe Leu
Glu Glu Met Leu Arg Thr Arg Val Gly Thr Lys His 1145 1150 1155 Ala
Ile Leu Leu Val Ala Val Ser Phe Val Thr Leu Ile Thr Gly 1160 1165
1170 Asn Met Ser Phe Arg Asp Leu Gly Arg Val Met Val Met Val Gly
1175 1180 1185 Ala Thr Met Thr Asp Asp Ile Gly Met Gly Val Thr Tyr
Leu Ala 1190 1195 1200 Leu Leu Ala Ala Phe Lys Val Arg Pro Thr Phe
Ala Ala Gly Leu 1205 1210
1215 Leu Leu Arg Lys Leu Thr Ser Lys Glu Leu Met Met Thr Thr Ile
1220 1225 1230 Gly Ile Val Leu Leu Ser Gln Ser Thr Ile Pro Glu Thr
Ile Leu 1235 1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly Met Met
Val Leu Lys Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr Gln Leu
Ala Val Thr Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro Asn Ala
Val Ile Leu Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys Thr Ile
Leu Ala Val Val Ser Val Ser Pro Leu Phe 1295 1300 1305 Leu Thr Ser
Ser Gln Gln Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315 1320 Thr
Ile Lys Gly Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu 1325 1330
1335 Ser Arg Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile
1340 1345 1350 Met Ala Val Gly Met Val Ser Ile Leu Ala Ser Ser Leu
Leu Lys 1355 1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu Val Ala
Gly Gly Leu Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr Gly Arg
Ser Ala Asp Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp Val Lys
Trp Glu Asp Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser Pro Ile
Leu Ser Ile Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met Ser Ile
Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr Ile Leu 1430 1435 1440 Ile
Arg Thr Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser 1445 1450
1455 Ile Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys
1460 1465 1470 Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro
Pro Met 1475 1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala Tyr Arg
Ile Lys Gln Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln Ile Gly
Ala Gly Val Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr Met Trp
His Val Thr Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys Gly Lys
Arg Ile Glu Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys Asp Leu
Ile Ser Tyr Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555 1560 Trp
Lys Glu Gly Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly 1565 1570
1575 Lys Asn Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe Lys Thr
1580 1585 1590 Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp Phe Ser
Pro Gly 1595 1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly
Lys Val Val Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val Thr Arg
Ser Gly Ala Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr Glu Lys
Ser Ile Glu Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp Ile Phe
Arg Lys Arg Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His Pro Gly
Ala Gly Lys Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675 1680 Arg
Glu Ala Ile Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro 1685 1690
1695 Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu
1700 1705 1710 Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala Val His
Thr Gly 1715 1720 1725 Arg Glu Ile Val Asp Leu Met Cys His Ala Thr
Phe Thr Met Arg 1730 1735 1740 Leu Leu Ser Pro Val Arg Val Pro Asn
Tyr Asn Leu Ile Ile Met 1745 1750 1755 Asp Glu Ala His Phe Thr Asp
Pro Ala Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser Thr Arg
Val Glu Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met Thr Ala
Thr Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795 1800 Asn
Ala Pro Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser 1805 1810
1815 Trp Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly Lys Thr
1820 1825 1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn Asp Ile
Ala Ala 1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val Ile Gln
Leu Ser Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val Lys Thr
Arg Thr Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr Asp Ile
Ser Glu Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg Val Ile
Asp Pro Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu Thr Asp
Gly Glu Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915 1920 Val
Thr His Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg 1925 1930
1935 Asn Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly Glu Pro
1940 1945 1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys Glu Ala
Lys Met 1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile
Ile Pro Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys Val Asp
Ala Ile Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu Ala Arg
Lys Thr Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp Leu Pro
Val Trp Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly Ile Asn
Tyr Ala Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035 2040 Asn
Asn Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr 2045 2050
2055 Lys Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala
2060 2065 2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys
Glu Phe 2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu Asn Leu
Ile Thr Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met Thr Gln
Lys Ala Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val Leu His
Thr Ala Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His Ala Leu
Ser Glu Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu Leu Leu
Thr Leu Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155 2160 Phe
Leu Met Ser Ala Arg Gly Ile Gly Lys Met Thr Leu Gly Met 2165 2170
2175 Cys Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala Gln Ile
2180 2185 2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu Glu Phe
Phe Leu 2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu Lys Gln
Arg Thr Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val Val Ile
Ala Ile Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala Asn Glu
Met Gly Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu Gly Leu
Gly Ser Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn Ile Leu
Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275 2280 Tyr
Ala Val Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser 2285 2290
2295 Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile Ala Asn
2300 2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly Trp Pro
Leu Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu Ala Ile
Gly Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu Thr Ala
Ala Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile Ile Gly
Pro Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala Gln Lys
Arg Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr Val Asp
Gly Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395 2400 Asp
Pro Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val 2405 2410
2415 Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp Ala Leu
2420 2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile Ser Thr
Leu Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn Thr Thr
Ile Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly Ser Tyr
Leu Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met Lys Asn
Thr Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile Gly Glu
Thr Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn Ala Leu
Gly Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515 2520 Ile
Gln Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg 2525 2530
2535 Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala Lys Leu
2540 2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro Glu Gly
Lys Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser
Tyr Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu Val Lys
Gly Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu Pro Ile
Pro Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg Leu Gln
Ser Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu Lys Cys
Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635 2640 Asn
Pro Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu 2645 2650
2655 Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile Lys Val
2660 2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys Met Glu
Ala Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val Arg Asn
Pro Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr Trp Val
Ser Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val Asn Met
Ile Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met Arg Tyr
Lys Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu Gly Ser
Gly Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755 2760 Asn
Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu 2765 2770
2775 His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr Lys Thr
2780 2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly
Ser Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg Leu Leu
Thr Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr Gln Met
Ala Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln Arg Val
Phe Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu Pro Lys
Glu Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala Glu Trp
Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875 2880 Met
Cys Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 2885 2890
2895 Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys Ser Ala
2900 2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu Leu Val
Asp Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys Cys Glu
Thr Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu Lys Lys
Leu Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg Ala Ile
Trp Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu Phe Glu
Ala Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe Ser Arg
Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995 3000 His
Lys Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly 3005 3010
3015 Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile
3020 3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val Thr Asn
His Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu Ala Ile
Phe Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg Val Gln
Arg Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile Ile Ser
Arg Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly Thr Tyr
Gly Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln Leu Ile
Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115 3120 Gln
His Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu 3125 3130
3135 Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile Ser Gly
3140 3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg Phe Ala
Ser Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys Ile Arg
Lys Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly Trp Asn
Asp Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His Phe His
Glu Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val Val Pro
Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala Arg Ile
Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235 3240 Cys
Leu Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe 3245 3250
3255 His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala
3260 3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr Thr Trp
Ser Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr Glu Asp
Met Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln Glu Asn
Pro Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser Trp Glu
Glu Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln Trp Cys
Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr Trp Ala
Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355 3360 Leu
Ile Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys 3365 3370
3375 Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp 3380 3385
3390 265PRTArtificial SequenceDerived from Dengue-2 virus 26Gly Arg
Ile Gly Arg 1 5 275PRTArtificial SequenceDerived from Dengue-2
virus 27Gly Ala Gly Lys Thr 1 5 2810723DNAArtificial
SequenceDerived from Dengue virus serotype 2/Dengue virus serotype
4, DenVax-4g 28agttgttagt ctacgtggac cgacaaagac agattctttg
agggagctaa gctcaacgta 60gttctaacag ttttttaatt agagagcaga tctctgatga
ataaccaacg gaaaaaggcg 120aaaaacacgc ctttcaatat gctgaaacgc
gagagaaacc gcgtgtcgac tgtgcaacag 180ctgacaaaga gattctcact
tggaatgctg cagggacgag gaccattaaa actgttcatg 240gccctggtgg
cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga
300tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag
gaaagagatt 360ggaaggatgc tgaacatctt gaataggaga cgcagctctg
caggcatgat cattatgctg 420attccaacag tgatggcgtt ccatttaacc
acgcgtgatg gcgaacccct catgatagtg 480gcaaaacatg aaagggggag
acctctcttg tttaagacaa cagaggggat caacaaatgc 540actctcattg
ccatggactt gggtgaaatg tgtgaggaca ctgtcacgta taaatgcccc
600ttactggtca ataccgaacc tgaagacatt gattgctggt gcaatctcac
gtctacctgg 660gtcatgtatg ggacatgcac ccagagcgga gaacggagac
gagagaagcg ctcagtagct 720ttaacaccac attcaggaat gggattggaa
acaagagctg agacatggat gtcatcggaa 780ggggcttgga agcatgctca
gagagtagag agctggatac tcagaaaccc aggattcgcg 840ctcttggcag
gatttatggc ttatatgatt gggcaaacag gaatccagcg aactgtcttc
900tttgtcctaa tgatgctggt cgccccatcc tacggaatgc gatgcgtagg
agtaggaaac 960agagactttg tggaaggagt ctcaggtgga gcatgggtcg
atctggtgct agaacatgga 1020ggatgcgtca caaccatggc ccagggaaaa
ccaaccttgg attttgaact gactaagaca 1080acagccaagg aagtggctct
gttaagaacc tattgcattg aagcctcaat atcaaacata 1140accacggcaa
caagatgtcc aacgcaagga gagccttatc taaaagagga acaagaccaa
1200cagtacattt gccggagaga tgtggtagac agagggtggg gcaatggctg
tggcttgttt 1260ggaaaaggag gagttgtgac atgtgcgaag ttttcatgtt
cggggaagat aacaggcaat 1320ttggtccaaa ttgagaacct tgaatacaca
gtggttgtaa cagtccacaa tggagacacc 1380catgcagtag gaaatgacac
gtccaatcat ggagttacag ccacgataac tcccaggtca 1440ccatcggtgg
aagtcaaatt gccggactat ggagaactaa cactcgattg tgaacccagg
1500tctggaattg actttaatga gatgattctg atgaaaatga aaaagaaaac
atggcttgtg 1560cataagcaat ggtttttgga tctacctcta ccatggacag
caggagcaga cacatcagag 1620gttcactgga attacaaaga gagaatggtg
acatttaagg ttcctcatgc caagagacag 1680gatgtgacag tgctgggatc
tcaggaagga gccatgcatt ctgccctcgc tggagccaca 1740gaagtggact
ccggtgatgg aaatcacatg tttgcaggac atctcaagtg caaagtccgt
1800atggagaaat tgagaatcaa gggaatgtca tacacgatgt gttcaggaaa
gttctcaatt 1860gacaaagaga tggcagaaac acagcatggg acaacagtgg
tgaaagtcaa gtatgaaggt 1920gctggagctc cgtgtaaagt ccccatagag
ataagagatg tgaacaagga aaaagtggtt 1980gggcgtatca tctcatccac
ccctttggct gagaatacca acagtgtaac caacatagag 2040ttagaacccc
cctttgggga cagctacata gtgataggtg ttggaaacag tgcattaaca
2100ctccattggt tcaggaaagg gagttccatt ggcaagatgt ttgagtccac
atacagaggt 2160gcaaaacgaa tggccattct aggtgaaaca gcttgggatt
ttggttccgt tggtggactg 2220ttcacatcat tgggaaaggc tgtgcaccag
gtttttggaa gtgtgtatac aaccctgttt 2280ggaggagtct catggatgat
tagaatccta attgggttcc tagtgttgtg gattggcacg 2340aactcaagga
acacttcaat ggctatgacg tgcatagctg ccggcattgt gacactgtat
2400ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa
caaagaactg 2460aaatgtggca gtgggatttt catcacagac aacgtgcaca
catggacaga acaatacaag 2520ttccaaccag aatccccttc aaaactagct
tcagctatcc agaaagccca tgaagaggac 2580atttgtggaa tccgctcagt
aacaagactg gagaatctga tgtggaaaca aataacacca 2640gaattgaatc
acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc
2700aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga
gctgaagtat 2760tcatggaaaa catggggcaa agcaaaaatg ctctctacag
agtctcataa ccagaccttt 2820ctcattgatg gccccgaaac agcagaatgc
cccaacacaa atagagcttg gaattcgttg 2880gaagttgaag actatggctt
tggagtattc accaccaata tatggctaaa attgaaagaa 2940aaacaggatg
tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc
3000gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg
gaagatagag 3060aaagcctctt tcattgaagt taaaaactgc cactggccaa
aatcacacac cctctggagc 3120aatggagtgc tagaaagtga gatgataatt
ccaaagaatc tcgctggacc agtgtctcaa 3180cacaactata gaccaggcta
ccatacacaa ataacaggac catggcatct aggtaagctt 3240gagatggact
ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat
3300agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga
atggtgctgc 3360cgatcttgca cattaccacc gctaagatac agaggtgagg
atgggtgctg gtacgggatg 3420gaaatcagac cattgaagga gaaagaagag
aatttggtca actccttggt cacagctgga 3480catgggcagg tcgacaactt
ttcactagga gtcttgggaa tggcattgtt cctggaggaa 3540atgcttagga
cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg
3600acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt
tatggtaggc 3660gccactatga cggatgacat aggtatgggc gtgacttatc
ttgccctact agcagccttc 3720aaagtcagac caacttttgc agctggacta
ctcttgagaa agctgacctc caaggaattg 3780atgatgacta ctataggaat
tgtactcctc tcccagagca ccataccaga gaccattctt 3840gagttgactg
atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa
3900aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc
agtgatatta 3960caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg
tgtccgtttc cccactgctc 4020ttaacatcct cacagcaaaa aacagattgg
ataccattag cattgacgat caaaggtctc 4080aatccaacag ctatttttct
aacaaccctc tcaagaacca gcaagaaaag gagctggcca 4140ttaaatgagg
ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa
4200aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt
gtgctacgtg 4260ctcactggac gatcggccga tttggaactg gagagagcag
ccgatgtcaa atgggaagac 4320caggcagaga tatcaggaag cagtccaatc
ctgtcaataa caatatcaga agatggtagc 4380atgtcgataa aaaatgaaga
ggaagaacaa acactgacca tactcattag aacaggattg 4440ctggtgatct
caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg
4500tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc
cccacccatg 4560ggaaaggctg aactggaaga tggagcctat agaattaagc
aaaaagggat tcttggatat 4620tcccagatcg gagccggagt ttacaaagaa
ggaacattcc atacaatgtg gcatgtcaca 4680cgtggcgctg ttctaatgca
taaaggaaag aggattgaac catcatgggc ggacgtcaag 4740aaagacctaa
tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa
4800gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca
aacgaaacct 4860ggtcttttca aaaccaacgc cggaacaata ggtgctgtat
ctctggactt ttctcctgga 4920acgtcaggat ctccaattat cgacaaaaaa
ggaaaagttg tgggtcttta tggtaatggt 4980gttgttacaa ggagtggagc
atatgtgagt gctatagccc agactgaaaa aagcattgaa 5040gacaacccag
agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc
5100cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga
agctataaaa 5160cggggtttga gaacattaat cttggccccc actagagttg
tggcagctga aatggaggaa 5220gcccttagag gacttccaat aagataccag
accccagcca tcagagctgt gcacaccggg 5280cgggagattg tggacctaat
gtgtcatgcc acatttacca tgaggctgct atcaccagtt 5340agagtgccaa
actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt
5400atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc
tgggattttt 5460atgacagcca ctcccccggg aagcagagac ccatttcctc
agagcaatgc accaatcata 5520gatgaagaaa gagaaatccc tgaacgctcg
tggaattccg gacatgaatg ggtcacggat 5580tttaaaggga agactgtttg
gttcgttcca agtataaaag caggaaatga tatagcagct 5640tgcctgagga
aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag
5700tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat
ttcagaaatg 5760ggtgccaatt tcaaggctga gagggttata gaccccagac
gctgcatgaa accagtcata 5820ctaacagatg gtgaagagcg ggtgattctg
gcaggaccta tgccagtgac ccactctagt 5880gcagcacaaa gaagagggag
aataggaaga aatccaaaaa atgagaatga ccagtacata 5940tacatggggg
aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg
6000ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga
accagagcgt 6060gaaaaggtgg atgccattga tggcgaatac cgcttgagag
gagaagcaag gaaaaccttt 6120gtagacttaa tgagaagagg agacctacca
gtctggttgg cctacagagt ggcagctgaa 6180ggcatcaact acgcagacag
aaggtggtgt tttgatggag tcaagaacaa ccaaatccta 6240gaagaaaacg
tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc
6300agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt
taaggaattt 6360gcagccggaa gaaagtctct gaccctgaac ctaatcacag
aaatgggtag gctcccaacc 6420ttcatgactc agaaggcaag agacgcactg
gacaacttag cagtgctgca cacggctgag 6480gcaggtggaa gggcgtacaa
ccatgctctc agtgaactgc cggagaccct ggagacattg 6540cttttactga
cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga
6600aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag
catcctccta 6660tggtacgcac aaatacagcc acactggata gcagcttcaa
taatactgga gttttttctc 6720atagttttgc ttattccaga acctgaaaaa
cagagaacac cccaagacaa ccaactgacc 6780tacgttgtca tagccatcct
cacagtggtg gccgcaacca tggcaaacga gatgggtttc 6840ctagaaaaaa
cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc
6900aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc
cgtggccaca 6960acatttgtta caccaatgtt gagacatagc attgaaaatt
cctcagtgaa tgtgtcccta 7020acagctatag ccaaccaagc cacagtgtta
atgggtctcg ggaaaggatg gccattgtca 7080aagatggaca tcggagttcc
ccttctcgcc attggatgct actcacaagt caaccccata 7140actctcacag
cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc
7200caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat
gaaaaaccca 7260actgtcgatg gaataacagt gattgaccta gatccaatac
cttatgatcc aaagtttgaa 7320aagcagttgg gacaagtaat gctcctagtc
ctctgcgtga ctcaagtatt gatgatgagg 7380actacatggg ctctgtgtga
ggctttaacc ttagctaccg ggcccatctc cacattgtgg 7440gaaggaaatc
cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt
7500agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa
cacaaccaac 7560acaagaaggg gaactggcaa cataggagag acgcttggag
agaaatggaa aagccgattg 7620aacgcattgg gaaaaagtga attccagatc
tacaagaaaa gtggaatcca ggaagtggat 7680agaaccttag caaaagaagg
cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga 7740ggctcagcaa
aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta
7800gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact
aaagaatgta 7860agagaagtca aaggcctaac aaaaggagga ccaggacacg
aagaacccat ccccatgtca 7920acatatgggt ggaatctagt gcgtcttcaa
agtggagttg acgttttctt catcccgcca 7980gaaaagtgtg acacattatt
gtgtgacata ggggagtcat caccaaatcc cacagtggaa 8040gcaggacgaa
cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa
8100ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat
ggaagcacta 8160caaaggaaat atggaggagc cttagtgagg aatccactct
cacgaaactc cacacatgag 8220atgtactggg tatccaatgc ttccgggaac
atagtgtcat cagtgaacat gatttcaagg 8280atgttgatca acagatttac
aatgagatac aagaaagcca cttacgagcc ggatgttgac 8340ctcggaagcg
gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt
8400gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta
tgaccaagac 8460cacccataca aaacgtgggc ataccatggt agctatgaaa
caaaacagac tggatcagca 8520tcatccatgg tcaacggagt ggtcaggctg
ctgacaaaac cttgggacgt cgtccccatg 8580gtgacacaga tggcaatgac
agacacgact ccatttggac aacagcgcgt ttttaaagag 8640aaagtggaca
cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca
8700gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg
caccagagaa 8760gaattcacaa gaaaggtgag aagcaatgca gccttggggg
ccatattcac tgatgagaac 8820aagtggaagt cggcacgtga ggctgttgaa
gatagtaggt tttgggagct ggttgacaag 8880gaaaggaatc tccatcttga
aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa 8940agagagaaga
agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg
9000tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga
agatcactgg 9060ttctccagag agaactccct gagtggagtg gaaggagaag
ggctgcacaa gctaggttac 9120attctaagag acgtgagcaa gaaagaggga
ggagcaatgt atgccgatga caccgcagga 9180tgggatacaa gaatcacact
agaagaccta aaaaatgaag aaatggtaac aaaccacatg 9240gaaggagaac
acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg
9300gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc
gagaagagac 9360caaagaggta gtggacaagt tggcacctat ggactcaata
ctttcaccaa tatggaagcc 9420caactaatca gacagatgga gggagaagga
gtctttaaaa gcattcagca cctaacaatc 9480acagaagaaa tcgctgtgca
aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga 9540atggccatca
gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct
9600ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg
ggaaccttca 9660agaggatgga atgattggac acaagtgccc ttctgttcac
accatttcca tgagttaatc 9720atgaaagacg gtcgcgtact cgttgttcca
tgtagaaacc aagatgaact gattggcaga 9780gcccgaatct cccaaggagc
agggtggtct ttgcgggaga cggcctgttt ggggaagtct 9840tacgcccaaa
tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat
9900gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac
ctggtccata 9960catgctaaac atgaatggat gacaacggaa gacatgctga
cagtctggaa cagggtgtgg 10020attcaagaaa acccatggat ggaagacaaa
actccagtgg aatcatggga ggaaatccca 10080tacttgggga aaagagaaga
ccaatggtgc ggctcattga ttgggttaac aagcagggcc 10140acctgggcaa
agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa
10200gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga
agaagcagga 10260gttctgtggt agaaagcaaa actaacatga aacaaggcta
gaagtcaggt cggattaagc 10320catagtacgg aaaaaactat gctacctgtg
agccccgtcc aaggacgtta aaagaagtca 10380ggccatcata aatgccatag
cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg 10440tgtaaaaaat
ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc
10500ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa
ggcgagatga 10560agctgtagtc tcgctggaag gactagaggt tagaggagac
ccccccgaaa caaaaaacag 10620catattgacg ctgggaaaga ccagagatcc
tgctgtctcc tcagcatcat tccaggcaca 10680gaacgccaga aaatggaatg
gtgctgttga atcaacaggt tct 10723293391PRTArtificial SequenceDerived
from Dengue virus serotype 2/Dengue virus serotype 4, DenVax-4g
29Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 1
5 10 15 Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys
Arg 20 25 30 Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys
Leu Phe Met 35 40 45 Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile
Pro Pro Thr Ala Gly 50 55 60 Ile Leu Lys Arg Trp Gly Thr Ile Lys
Lys Ser Lys Ala Ile Asn Val 65 70 75 80 Leu Arg Gly Phe Arg Lys Glu
Ile Gly Arg Met Leu Asn Ile Leu Asn 85 90 95 Arg Arg Arg Ser Ser
Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 100 105 110 Met Ala Phe
His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val 115 120 125 Ala
Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly 130 135
140 Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu
145 150 155 160 Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr
Glu Pro Glu 165 170 175 Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr
Trp Val Met Tyr Gly 180 185 190 Thr Cys Thr Gln Ser Gly Glu Arg Arg
Arg Glu Lys Arg Ser Val Ala 195 200 205 Leu Thr Pro His Ser Gly Met
Gly Leu Glu Thr Arg Ala Glu Thr Trp 210 215 220 Met Ser Ser Glu Gly
Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 225 230 235 240 Ile Leu
Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr 245 250 255
Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met 260
265 270 Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly
Asn 275 280 285 Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val
Asp Leu Val 290 295 300 Leu Glu His Gly Gly Cys Val Thr Thr Met Ala
Gln Gly Lys Pro Thr 305 310 315 320 Leu Asp Phe Glu Leu Thr Lys Thr
Thr Ala Lys Glu Val Ala Leu Leu 325 330 335 Arg Thr Tyr Cys Ile Glu
Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 340 345 350 Arg Cys Pro Thr
Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 355 360 365 Gln Tyr
Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly 370 375 380
Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser 385
390 395 400 Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn
Leu Glu 405 410 415 Tyr Thr Val Val Val Thr Val His Asn Gly Asp Thr
His Ala Val Gly 420 425 430 Asn Asp Thr Ser Asn His Gly Val Thr Ala
Thr Ile Thr Pro Arg Ser 435 440 445 Pro Ser Val Glu Val Lys Leu Pro
Asp Tyr Gly Glu Leu Thr Leu Asp 450 455 460 Cys Glu Pro Arg Ser Gly
Ile Asp Phe Asn Glu Met Ile Leu Met Lys 465 470 475 480 Met Lys Lys
Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 485 490 495 Pro
Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn 500 505
510 Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln
515 520 525 Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser
Ala Leu 530 535 540 Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn
His Met Phe Ala 545 550 555 560 Gly His Leu Lys Cys Lys Val Arg Met
Glu Lys Leu Arg Ile Lys Gly 565 570 575 Met Ser Tyr Thr Met Cys Ser
Gly Lys Phe Ser Ile Asp Lys Glu Met 580 585 590 Ala Glu Thr Gln His
Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 595 600 605 Ala Gly Ala
Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys 610 615 620 Glu
Lys Val Val Gly Arg Ile Ile
Ser Ser Thr Pro Leu Ala Glu Asn 625 630 635 640 Thr Asn Ser Val Thr
Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 645 650 655 Tyr Ile Val
Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe 660 665 670 Arg
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly 675 680
685 Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser
690 695 700 Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln
Val Phe 705 710 715 720 Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val
Ser Trp Met Ile Arg 725 730 735 Ile Leu Ile Gly Phe Leu Val Leu Trp
Ile Gly Thr Asn Ser Arg Asn 740 745 750 Thr Ser Met Ala Met Thr Cys
Ile Ala Ala Gly Ile Val Thr Leu Tyr 755 760 765 Leu Gly Val Met Val
Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 770 775 780 Asn Lys Glu
Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 785 790 795 800
His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 805
810 815 Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly
Ile 820 825 830 Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln
Ile Thr Pro 835 840 845 Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val
Lys Leu Thr Ile Met 850 855 860 Thr Gly Asp Ile Lys Gly Ile Met Gln
Ala Gly Lys Arg Ser Leu Arg 865 870 875 880 Pro Gln Pro Thr Glu Leu
Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 885 890 895 Lys Met Leu Ser
Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 900 905 910 Pro Glu
Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 915 920 925
Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 930
935 940 Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met
Ser 945 950 955 960 Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp
Met Gly Tyr Trp 965 970 975 Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys
Ile Glu Lys Ala Ser Phe 980 985 990 Ile Glu Val Lys Asn Cys His Trp
Pro Lys Ser His Thr Leu Trp Ser 995 1000 1005 Asn Gly Val Leu Glu
Ser Glu Met Ile Ile Pro Lys Asn Leu Ala 1010 1015 1020 Gly Pro Val
Ser Gln His Asn Tyr Arg Pro Gly Tyr His Thr Gln 1025 1030 1035 Ile
Thr Gly Pro Trp His Leu Gly Lys Leu Glu Met Asp Phe Asp 1040 1045
1050 Phe Cys Asp Gly Thr Thr Val Val Val Thr Glu Asp Cys Gly Asn
1055 1060 1065 Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser Gly Lys
Leu Ile 1070 1075 1080 Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro
Pro Leu Arg Tyr 1085 1090 1095 Arg Gly Glu Asp Gly Cys Trp Tyr Gly
Met Glu Ile Arg Pro Leu 1100 1105 1110 Lys Glu Lys Glu Glu Asn Leu
Val Asn Ser Leu Val Thr Ala Gly 1115 1120 1125 His Gly Gln Val Asp
Asn Phe Ser Leu Gly Val Leu Gly Met Ala 1130 1135 1140 Leu Phe Leu
Glu Glu Met Leu Arg Thr Arg Val Gly Thr Lys His 1145 1150 1155 Ala
Ile Leu Leu Val Ala Val Ser Phe Val Thr Leu Ile Thr Gly 1160 1165
1170 Asn Met Ser Phe Arg Asp Leu Gly Arg Val Met Val Met Val Gly
1175 1180 1185 Ala Thr Met Thr Asp Asp Ile Gly Met Gly Val Thr Tyr
Leu Ala 1190 1195 1200 Leu Leu Ala Ala Phe Lys Val Arg Pro Thr Phe
Ala Ala Gly Leu 1205 1210 1215 Leu Leu Arg Lys Leu Thr Ser Lys Glu
Leu Met Met Thr Thr Ile 1220 1225 1230 Gly Ile Val Leu Leu Ser Gln
Ser Thr Ile Pro Glu Thr Ile Leu 1235 1240 1245 Glu Leu Thr Asp Ala
Leu Ala Leu Gly Met Met Val Leu Lys Met 1250 1255 1260 Val Arg Asn
Met Glu Lys Tyr Gln Leu Ala Val Thr Ile Met Ala 1265 1270 1275 Ile
Leu Cys Val Pro Asn Ala Val Ile Leu Gln Asn Ala Trp Lys 1280 1285
1290 Val Ser Cys Thr Ile Leu Ala Val Val Ser Val Ser Pro Leu Leu
1295 1300 1305 Leu Thr Ser Ser Gln Gln Lys Thr Asp Trp Ile Pro Leu
Ala Leu 1310 1315 1320 Thr Ile Lys Gly Leu Asn Pro Thr Ala Ile Phe
Leu Thr Thr Leu 1325 1330 1335 Ser Arg Thr Ser Lys Lys Arg Ser Trp
Pro Leu Asn Glu Ala Ile 1340 1345 1350 Met Ala Val Gly Met Val Ser
Ile Leu Ala Ser Ser Leu Leu Lys 1355 1360 1365 Asn Asp Ile Pro Met
Thr Gly Pro Leu Val Ala Gly Gly Leu Leu 1370 1375 1380 Thr Val Cys
Tyr Val Leu Thr Gly Arg Ser Ala Asp Leu Glu Leu 1385 1390 1395 Glu
Arg Ala Ala Asp Val Lys Trp Glu Asp Gln Ala Glu Ile Ser 1400 1405
1410 Gly Ser Ser Pro Ile Leu Ser Ile Thr Ile Ser Glu Asp Gly Ser
1415 1420 1425 Met Ser Ile Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr
Ile Leu 1430 1435 1440 Ile Arg Thr Gly Leu Leu Val Ile Ser Gly Leu
Phe Pro Val Ser 1445 1450 1455 Ile Pro Ile Thr Ala Ala Ala Trp Tyr
Leu Trp Glu Val Lys Lys 1460 1465 1470 Gln Arg Ala Gly Val Leu Trp
Asp Val Pro Ser Pro Pro Pro Met 1475 1480 1485 Gly Lys Ala Glu Leu
Glu Asp Gly Ala Tyr Arg Ile Lys Gln Lys 1490 1495 1500 Gly Ile Leu
Gly Tyr Ser Gln Ile Gly Ala Gly Val Tyr Lys Glu 1505 1510 1515 Gly
Thr Phe His Thr Met Trp His Val Thr Arg Gly Ala Val Leu 1520 1525
1530 Met His Lys Gly Lys Arg Ile Glu Pro Ser Trp Ala Asp Val Lys
1535 1540 1545 Lys Asp Leu Ile Ser Tyr Gly Gly Gly Trp Lys Leu Glu
Gly Glu 1550 1555 1560 Trp Lys Glu Gly Glu Glu Val Gln Val Leu Ala
Leu Glu Pro Gly 1565 1570 1575 Lys Asn Pro Arg Ala Val Gln Thr Lys
Pro Gly Leu Phe Lys Thr 1580 1585 1590 Asn Ala Gly Thr Ile Gly Ala
Val Ser Leu Asp Phe Ser Pro Gly 1595 1600 1605 Thr Ser Gly Ser Pro
Ile Ile Asp Lys Lys Gly Lys Val Val Gly 1610 1615 1620 Leu Tyr Gly
Asn Gly Val Val Thr Arg Ser Gly Ala Tyr Val Ser 1625 1630 1635 Ala
Ile Ala Gln Thr Glu Lys Ser Ile Glu Asp Asn Pro Glu Ile 1640 1645
1650 Glu Asp Asp Ile Phe Arg Lys Arg Arg Leu Thr Ile Met Asp Leu
1655 1660 1665 His Pro Gly Ala Gly Lys Thr Lys Arg Tyr Leu Pro Ala
Ile Val 1670 1675 1680 Arg Glu Ala Ile Lys Arg Gly Leu Arg Thr Leu
Ile Leu Ala Pro 1685 1690 1695 Thr Arg Val Val Ala Ala Glu Met Glu
Glu Ala Leu Arg Gly Leu 1700 1705 1710 Pro Ile Arg Tyr Gln Thr Pro
Ala Ile Arg Ala Val His Thr Gly 1715 1720 1725 Arg Glu Ile Val Asp
Leu Met Cys His Ala Thr Phe Thr Met Arg 1730 1735 1740 Leu Leu Ser
Pro Val Arg Val Pro Asn Tyr Asn Leu Ile Ile Met 1745 1750 1755 Asp
Glu Ala His Phe Thr Asp Pro Ala Ser Ile Ala Ala Arg Gly 1760 1765
1770 Tyr Ile Ser Thr Arg Val Glu Met Gly Glu Ala Ala Gly Ile Phe
1775 1780 1785 Met Thr Ala Thr Pro Pro Gly Ser Arg Asp Pro Phe Pro
Gln Ser 1790 1795 1800 Asn Ala Pro Ile Ile Asp Glu Glu Arg Glu Ile
Pro Glu Arg Ser 1805 1810 1815 Trp Asn Ser Gly His Glu Trp Val Thr
Asp Phe Lys Gly Lys Thr 1820 1825 1830 Val Trp Phe Val Pro Ser Ile
Lys Ala Gly Asn Asp Ile Ala Ala 1835 1840 1845 Cys Leu Arg Lys Asn
Gly Lys Lys Val Ile Gln Leu Ser Arg Lys 1850 1855 1860 Thr Phe Asp
Ser Glu Tyr Val Lys Thr Arg Thr Asn Asp Trp Asp 1865 1870 1875 Phe
Val Val Thr Thr Asp Ile Ser Glu Met Gly Ala Asn Phe Lys 1880 1885
1890 Ala Glu Arg Val Ile Asp Pro Arg Arg Cys Met Lys Pro Val Ile
1895 1900 1905 Leu Thr Asp Gly Glu Glu Arg Val Ile Leu Ala Gly Pro
Met Pro 1910 1915 1920 Val Thr His Ser Ser Ala Ala Gln Arg Arg Gly
Arg Ile Gly Arg 1925 1930 1935 Asn Pro Lys Asn Glu Asn Asp Gln Tyr
Ile Tyr Met Gly Glu Pro 1940 1945 1950 Leu Glu Asn Asp Glu Asp Cys
Ala His Trp Lys Glu Ala Lys Met 1955 1960 1965 Leu Leu Asp Asn Ile
Asn Thr Pro Glu Gly Ile Ile Pro Ser Met 1970 1975 1980 Phe Glu Pro
Glu Arg Glu Lys Val Asp Ala Ile Asp Gly Glu Tyr 1985 1990 1995 Arg
Leu Arg Gly Glu Ala Arg Lys Thr Phe Val Asp Leu Met Arg 2000 2005
2010 Arg Gly Asp Leu Pro Val Trp Leu Ala Tyr Arg Val Ala Ala Glu
2015 2020 2025 Gly Ile Asn Tyr Ala Asp Arg Arg Trp Cys Phe Asp Gly
Val Lys 2030 2035 2040 Asn Asn Gln Ile Leu Glu Glu Asn Val Glu Val
Glu Ile Trp Thr 2045 2050 2055 Lys Glu Gly Glu Arg Lys Lys Leu Lys
Pro Arg Trp Leu Asp Ala 2060 2065 2070 Arg Ile Tyr Ser Asp Pro Leu
Ala Leu Lys Glu Phe Lys Glu Phe 2075 2080 2085 Ala Ala Gly Arg Lys
Ser Leu Thr Leu Asn Leu Ile Thr Glu Met 2090 2095 2100 Gly Arg Leu
Pro Thr Phe Met Thr Gln Lys Ala Arg Asp Ala Leu 2105 2110 2115 Asp
Asn Leu Ala Val Leu His Thr Ala Glu Ala Gly Gly Arg Ala 2120 2125
2130 Tyr Asn His Ala Leu Ser Glu Leu Pro Glu Thr Leu Glu Thr Leu
2135 2140 2145 Leu Leu Leu Thr Leu Leu Ala Thr Val Thr Gly Gly Ile
Phe Leu 2150 2155 2160 Phe Leu Met Ser Gly Arg Gly Ile Gly Lys Met
Thr Leu Gly Met 2165 2170 2175 Cys Cys Ile Ile Thr Ala Ser Ile Leu
Leu Trp Tyr Ala Gln Ile 2180 2185 2190 Gln Pro His Trp Ile Ala Ala
Ser Ile Ile Leu Glu Phe Phe Leu 2195 2200 2205 Ile Val Leu Leu Ile
Pro Glu Pro Glu Lys Gln Arg Thr Pro Gln 2210 2215 2220 Asp Asn Gln
Leu Thr Tyr Val Val Ile Ala Ile Leu Thr Val Val 2225 2230 2235 Ala
Ala Thr Met Ala Asn Glu Met Gly Phe Leu Glu Lys Thr Lys 2240 2245
2250 Lys Asp Leu Gly Leu Gly Ser Ile Ala Thr Gln Gln Pro Glu Ser
2255 2260 2265 Asn Ile Leu Asp Ile Asp Leu Arg Pro Ala Ser Ala Trp
Thr Leu 2270 2275 2280 Tyr Ala Val Ala Thr Thr Phe Val Thr Pro Met
Leu Arg His Ser 2285 2290 2295 Ile Glu Asn Ser Ser Val Asn Val Ser
Leu Thr Ala Ile Ala Asn 2300 2305 2310 Gln Ala Thr Val Leu Met Gly
Leu Gly Lys Gly Trp Pro Leu Ser 2315 2320 2325 Lys Met Asp Ile Gly
Val Pro Leu Leu Ala Ile Gly Cys Tyr Ser 2330 2335 2340 Gln Val Asn
Pro Ile Thr Leu Thr Ala Ala Leu Phe Leu Leu Val 2345 2350 2355 Ala
His Tyr Ala Ile Ile Gly Pro Gly Leu Gln Ala Lys Ala Thr 2360 2365
2370 Arg Glu Ala Gln Lys Arg Ala Ala Ala Gly Ile Met Lys Asn Pro
2375 2380 2385 Thr Val Asp Gly Ile Thr Val Ile Asp Leu Asp Pro Ile
Pro Tyr 2390 2395 2400 Asp Pro Lys Phe Glu Lys Gln Leu Gly Gln Val
Met Leu Leu Val 2405 2410 2415 Leu Cys Val Thr Gln Val Leu Met Met
Arg Thr Thr Trp Ala Leu 2420 2425 2430 Cys Glu Ala Leu Thr Leu Ala
Thr Gly Pro Ile Ser Thr Leu Trp 2435 2440 2445 Glu Gly Asn Pro Gly
Arg Phe Trp Asn Thr Thr Ile Ala Val Ser 2450 2455 2460 Met Ala Asn
Ile Phe Arg Gly Ser Tyr Leu Ala Gly Ala Gly Leu 2465 2470 2475 Leu
Phe Ser Ile Met Lys Asn Thr Thr Asn Thr Arg Arg Gly Thr 2480 2485
2490 Gly Asn Ile Gly Glu Thr Leu Gly Glu Lys Trp Lys Ser Arg Leu
2495 2500 2505 Asn Ala Leu Gly Lys Ser Glu Phe Gln Ile Tyr Lys Lys
Ser Gly 2510 2515 2520 Ile Gln Glu Val Asp Arg Thr Leu Ala Lys Glu
Gly Ile Lys Arg 2525 2530 2535 Gly Glu Thr Asp His His Ala Val Ser
Arg Gly Ser Ala Lys Leu 2540 2545 2550 Arg Trp Phe Val Glu Arg Asn
Met Val Thr Pro Glu Gly Lys Val 2555 2560 2565 Val Asp Leu Gly Cys
Gly Arg Gly Gly Trp Ser Tyr Tyr Cys Gly 2570 2575 2580 Gly Leu Lys
Asn Val Arg Glu Val Lys Gly Leu Thr Lys Gly Gly 2585 2590 2595 Pro
Gly His Glu Glu Pro Ile Pro Met Ser Thr Tyr Gly Trp Asn 2600 2605
2610 Leu Val Arg Leu Gln Ser Gly Val Asp Val Phe Phe Ile Pro Pro
2615 2620 2625 Glu Lys Cys Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser
Ser Pro 2630 2635 2640 Asn Pro Thr Val Glu Ala Gly Arg Thr Leu Arg
Val Leu Asn Leu 2645 2650 2655 Val Glu Asn Trp Leu Asn Asn Asn Thr
Gln Phe Cys Ile Lys Val 2660 2665 2670 Leu Asn Pro Tyr Met Pro Ser
Val Ile Glu Lys Met Glu Ala Leu 2675 2680 2685 Gln Arg Lys Tyr Gly
Gly Ala Leu Val Arg Asn Pro Leu Ser Arg 2690 2695 2700 Asn Ser Thr
His Glu Met Tyr Trp Val Ser Asn Ala Ser Gly Asn 2705 2710 2715 Ile
Val Ser Ser Val Asn Met Ile Ser Arg Met Leu Ile Asn Arg 2720 2725
2730 Phe Thr Met Arg Tyr Lys Lys Ala Thr Tyr Glu Pro Asp Val Asp
2735 2740 2745 Leu Gly Ser Gly Thr Arg Asn Ile Gly Ile Glu Ser Glu
Ile Pro 2750 2755 2760 Asn Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys
Ile Lys Gln Glu 2765 2770 2775 His Glu Thr Ser Trp His Tyr Asp Gln
Asp His Pro Tyr Lys Thr 2780 2785 2790 Trp Ala Tyr His Gly Ser Tyr
Glu Thr Lys Gln Thr Gly Ser Ala 2795 2800 2805 Ser Ser Met Val Asn
Gly Val Val Arg Leu Leu Thr Lys Pro Trp 2810 2815 2820 Asp Val Val
Pro Met Val Thr Gln Met Ala Met Thr Asp Thr Thr 2825 2830 2835 Pro
Phe Gly Gln Gln Arg Val
Phe Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu Pro Lys
Glu Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala Glu Trp
Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875 2880 Met
Cys Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 2885 2890
2895 Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys Ser Ala
2900 2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu Leu Val
Asp Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys Cys Glu
Thr Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu Lys Lys
Leu Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg Ala Ile
Trp Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu Phe Glu
Ala Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe Ser Arg
Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995 3000 His
Lys Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly 3005 3010
3015 Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile
3020 3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val Thr Asn
His Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu Ala Ile
Phe Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg Val Gln
Arg Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile Ile Ser
Arg Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly Thr Tyr
Gly Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln Leu Ile
Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115 3120 Gln
His Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu 3125 3130
3135 Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile Ser Gly
3140 3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg Phe Ala
Ser Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys Ile Arg
Lys Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly Trp Asn
Asp Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His Phe His
Glu Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val Val Pro
Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala Arg Ile
Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235 3240 Cys
Leu Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe 3245 3250
3255 His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala
3260 3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr Thr Trp
Ser Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr Glu Asp
Met Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln Glu Asn
Pro Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser Trp Glu
Glu Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln Trp Cys
Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr Trp Ala
Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355 3360 Leu
Ile Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys 3365 3370
3375 Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp 3380 3385
3390 3010723DNAArtificial SequenceDerived from Dengue virus
serotype 2/Dengue virus serotype 4, Denvax-4f 30agttgttagt
ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta 60gttctaacag
ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtgaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg
aaaacgatct ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa
catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt
2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg
gaattcgttg 2880gaagttgaag actatggctt tggagtattc accaccaata
tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc
atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg atatgggtta
ttggatagaa agtgcactca atgacacatg gaagatagag 3060aaagcctctt
tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc
3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc
agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa ataacaggac
catggcatct aggtaagctt 3240gagatggact ttgatttctg tgatggaaca
acagtggtag tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac
aaccactgcc tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca
cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg
3420gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt
cacagctgga 3480catgggcagg tcgacaactt ttcactagga gtcttgggaa
tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat
gcaatactac tagttgcagt ttcttttgtg 3600acattgatca cagggaacat
gtcctttaga gacctgggaa gagtgatggt tatggtaggc 3660gccactatga
cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
caaggaattg 3780atgatgacta ctataggaat tgtactcctc tcccagagca
ccataccaga gaccattctt 3840gagttgactg atgcgttagc cttaggcatg
atggtcctca aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac
tatcatggct atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat
ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc
4020ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat
caaaggtctc 4080aatccaacag ctatttttct aacaaccctc tcaagaacca
gcaagaaaag gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg
gtgagcattt tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg
accattagtg gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac
gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac
4320caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga
agatggtagc 4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca
tactcattag aacaggattg 4440ctggtgatct caggactttt tcctgtatca
ataccaatca cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg
ggccggagta ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg
aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat
4620tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg
gcatgtcaca 4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac
catcatgggc ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg
aagttagaag gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact
ggagcctgga aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca
aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga
4920acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta
tggtaatggt 4980gttgttacaa ggagtggagc atatgtgagt gctatagccc
agactgaaaa aagcattgaa 5040gacaacccag agatcgaaga tgacattttc
cgaaagagaa gactgaccat catggacctc 5100cacccaggag cgggaaagac
gaagagatac cttccggcca tagtcagaga agctataaaa 5160cggggtttga
gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa
5220gcccttagag gacttccaat aagataccag accccagcca tcagagctgt
gcacaccggg 5280cgggagattg tggacctaat gtgtcatgcc acatttacca
tgaggctgct atcaccagtt 5340agagtgccaa actacaacct gattatcatg
gacgaagccc atttcacaga cccagcaagt 5400atagcagcta gaggatacat
ctcaactcga gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca
ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata
5520gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg
ggtcacggat 5580tttaaaggga agactgtttg gttcgttcca agtataaaag
caggaaatga tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata
caactcagta ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa
tgattgggac ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt
tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata
5820ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac
ccactctagt 5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa
atgagaatga ccagtacata 5940tacatggggg aacctctgga aaatgatgaa
gactgtgcac actggaaaga agctaaaatg 6000ctcctagata acatcaacac
gccagaagga atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg
atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt
6120gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt
ggcagctgaa 6180ggcatcaact acgcagacag aaggtggtgt tttgatggag
tcaagaacaa ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca
aaagaagggg aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat
ctattctgac ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa
gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc
6420ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca
cacggctgag 6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc
cggagaccct ggagacattg 6540cttttactga cacttctggc tacagtcacg
ggagggatct ttttattctt gatgagcgga 6600aggggcatag ggaagatgac
cctgggaatg tgctgcataa tcacggctag catcctccta 6660tggtacgcac
aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc
6720atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa
ccaactgacc 6780tacgttgtca tagccatcct cacagtggtg gccgcaacca
tggcaaacga gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg
ggaagcattg caacccagca acccgagagc 6900aacatcctgg acatagatct
acgtcctgca tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta
caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta
7020acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg
gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc attggatgct
actcacaagt caaccccata 7140actctcacag cagctctttt cttattggta
gcacattatg ccatcatagg gccaggactc 7200caagcaaaag caaccagaga
agctcagaaa agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg
gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa
7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt
gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc ttagctaccg
ggcccatctc cacattgtgg 7440gaaggaaatc cagggaggtt ttggaacact
accattgcgg tgtcaatggc taacattttt 7500agagggagtt acttggccgg
agctggactt ctcttttcta ttatgaagaa cacaaccaac 7560acaagaaggg
gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg
7620aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca
ggaagtggat 7680agaaccttag caaaagaagg cattaaaaga ggagaaacgg
accatcacgc tgtgtcgcga 7740ggctcagcaa aactgagatg gttcgttgag
agaaacatgg tcacaccaga agggaaagta 7800gtggacctcg gttgtggcag
aggaggctgg tcatactatt gtggaggact aaagaatgta 7860agagaagtca
aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca
7920acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt
catcccgcca 7980gaaaagtgtg acacattatt gtgtgacata ggggagtcat
caccaaatcc cacagtggaa 8040gcaggacgaa cactcagagt ccttaactta
gtagaaaatt ggttgaacaa caacactcaa 8100ttttgcataa aggttctcaa
cccatatatg ccctcagtca tagaaaaaat ggaagcacta 8160caaaggaaat
atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag
8220atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat
gatttcaagg 8280atgttgatca acagatttac aatgagatac aagaaagcca
cttacgagcc ggatgttgac 8340ctcggaagcg gaacccgtaa catcgggatt
gaaagtgaga taccaaacct agatataatt 8400gggaaaagaa tagaaaaaat
aaagcaagag catgaaacat catggcacta tgaccaagac 8460cacccataca
aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca
8520tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt
cgtccccatg 8580gtgacacaga tggcaatgac agacacgact ccatttggac
aacagcgcgt ttttaaagag 8640aaagtggaca cgagaaccca agaaccgaaa
gaaggcacga agaaactaat gaaaataaca 8700gcagagtggc tttggaaaga
attagggaag aaaaagacac ccaggatgtg caccagagaa 8760gaattcacaa
gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac
8820aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct
ggttgacaag 8880gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg
tgtacaacat gatgggaaaa 8940agagagaaga agctagggga attcggcaag
gcaaaaggca gcagagccat atggtacatg 9000tggcttggag cacgcttctt
agagtttgaa gccctaggat tcttaaatga agatcactgg 9060ttctccagag
agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac
9120attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga
caccgcagga 9180tgggatacaa gaatcacact agaagaccta aaaaatgaag
aaatggtaac aaaccacatg 9240gaaggagaac acaagaaact agccgaggcc
attttcaaac taacgtacca aaacaaggtg 9300gtgcgtgtgc aaagaccaac
accaagaggc acagtaatgg acatcatatc gagaagagac 9360caaagaggta
gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc
9420caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca
cctaacaatc 9480acagaagaaa tcgctgtgca aaactggtta gcaagagtgg
ggcgcgaaag gttatcaaga 9540atggccatca gtggagatga ttgtgttgtg
aaacctttag atgacaggtt cgcaagcgct 9600ttaacagctc taaatgacat
gggaaagatt aggaaagaca tacaacaatg ggaaccttca 9660agaggatgga
atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc
9720atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact
gattggcaga 9780gcccgaatct cccaaggagc agggtggtct ttgcgggaga
cggcctgttt ggggaagtct 9840tacgcccaaa tgtggagctt gatgtacttc
cacagacgcg acctcaggct ggcggcaaat 9900gctatttgct cggcagtacc
atcacattgg gttccaacaa gtcgaacaac ctggtccata 9960catgctaaac
atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg
10020attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga
ggaaatccca 10080tacttgggga aaagagaaga ccaatggtgc ggctcattga
ttgggttaac aagcagggcc 10140acctgggcaa agaacatcca agcagcaata
aatcaagtta gatcccttat aggcaatgaa 10200gaatacacag attacatgcc
atccatgaaa agattcagaa gagaagagga agaagcagga 10260gttctgtggt
agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc
10320catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta
aaagaagtca 10380ggccatcata aatgccatag cttgagtaaa ctatgcagcc
tgtagctcca cctgagaagg 10440tgtaaaaaat ccgggaggcc acaaaccatg
gaagctgtac gcatggcgta gtggactagc 10500ggttagagga gacccctccc
ttacaaatcg cagcaacaat gggggcccaa ggcgagatga 10560agctgtagtc
tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag
10620catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat
tccaggcaca 10680gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct
10723313391PRTArtificial SequenceDerived from Dengue virus serotype
2/Dengue virus serotype 4, DenVax-4f 31Met Asn Asn Gln Arg Lys Lys
Ala Lys Asn Thr Pro Phe Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn
Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu
Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala
Leu Val Ala Phe Leu Arg Phe Leu
Thr Ile Pro Pro Thr Ala Gly 50 55 60 Ile Leu Lys Arg Trp Gly Thr
Ile Lys Lys Ser Lys Ala Ile Asn Val 65 70 75 80 Leu Arg Gly Phe Arg
Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 85 90 95 Arg Arg Arg
Ser Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 100 105 110 Met
Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val 115 120
125 Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly
130 135 140 Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met
Cys Glu 145 150 155 160 Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val
Asn Thr Glu Pro Glu 165 170 175 Asp Ile Asp Cys Trp Cys Asn Leu Thr
Ser Thr Trp Val Met Tyr Gly 180 185 190 Thr Cys Thr Gln Ser Gly Glu
Arg Arg Arg Glu Lys Arg Ser Val Ala 195 200 205 Leu Thr Pro His Ser
Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp 210 215 220 Met Ser Ser
Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 225 230 235 240
Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr 245
250 255 Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu
Met 260 265 270 Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly
Val Gly Asn 275 280 285 Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala
Trp Val Asp Leu Val 290 295 300 Leu Glu His Gly Gly Cys Val Thr Thr
Met Ala Gln Gly Lys Pro Thr 305 310 315 320 Leu Asp Phe Glu Leu Thr
Lys Thr Thr Ala Lys Glu Val Ala Leu Leu 325 330 335 Arg Thr Tyr Cys
Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 340 345 350 Arg Cys
Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 355 360 365
Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly 370
375 380 Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe
Ser 385 390 395 400 Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile
Glu Asn Leu Glu 405 410 415 Tyr Thr Val Val Val Thr Val His Asn Gly
Asp Thr His Ala Val Gly 420 425 430 Asn Asp Thr Ser Asn His Gly Val
Thr Ala Thr Ile Thr Pro Arg Ser 435 440 445 Pro Ser Val Glu Val Lys
Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp 450 455 460 Cys Glu Pro Arg
Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys 465 470 475 480 Met
Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 485 490
495 Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn
500 505 510 Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys
Arg Gln 515 520 525 Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met
His Ser Ala Leu 530 535 540 Ala Gly Ala Thr Glu Val Asp Ser Gly Asp
Gly Asn His Met Phe Ala 545 550 555 560 Gly His Leu Lys Cys Lys Val
Arg Met Glu Lys Leu Arg Ile Lys Gly 565 570 575 Met Ser Tyr Thr Met
Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met 580 585 590 Ala Glu Thr
Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 595 600 605 Ala
Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys 610 615
620 Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn
625 630 635 640 Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe
Gly Asp Ser 645 650 655 Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu
Thr Leu His Trp Phe 660 665 670 Arg Lys Gly Ser Ser Ile Gly Lys Met
Phe Glu Ser Thr Tyr Arg Gly 675 680 685 Ala Lys Arg Met Ala Ile Leu
Gly Glu Thr Ala Trp Asp Phe Gly Ser 690 695 700 Val Gly Gly Leu Phe
Thr Ser Leu Gly Lys Ala Val His Gln Val Phe 705 710 715 720 Gly Ser
Val Tyr Thr Thr Leu Phe Gly Gly Val Ser Trp Met Ile Arg 725 730 735
Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn 740
745 750 Thr Ser Met Ala Met Thr Cys Ile Ala Ala Gly Ile Val Thr Leu
Tyr 755 760 765 Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val
Ser Trp Lys 770 775 780 Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe
Ile Thr Asp Asn Val 785 790 795 800 His Thr Trp Thr Glu Gln Tyr Lys
Phe Gln Pro Glu Ser Pro Ser Lys 805 810 815 Leu Ala Ser Ala Ile Gln
Lys Ala His Glu Glu Asp Ile Cys Gly Ile 820 825 830 Arg Ser Val Thr
Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 835 840 845 Glu Leu
Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 850 855 860
Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 865
870 875 880 Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly
Lys Ala 885 890 895 Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe
Leu Ile Asp Gly 900 905 910 Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn
Arg Ala Trp Asn Ser Leu 915 920 925 Glu Val Glu Asp Tyr Gly Phe Gly
Val Phe Thr Thr Asn Ile Trp Leu 930 935 940 Lys Leu Lys Glu Lys Gln
Asp Val Phe Cys Asp Ser Lys Leu Met Ser 945 950 955 960 Ala Ala Ile
Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 965 970 975 Ile
Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 980 985
990 Ile Glu Val Lys Asn Cys His Trp Pro Lys Ser His Thr Leu Trp Ser
995 1000 1005 Asn Gly Val Leu Glu Ser Glu Met Ile Ile Pro Lys Asn
Leu Ala 1010 1015 1020 Gly Pro Val Ser Gln His Asn Tyr Arg Pro Gly
Tyr His Thr Gln 1025 1030 1035 Ile Thr Gly Pro Trp His Leu Gly Lys
Leu Glu Met Asp Phe Asp 1040 1045 1050 Phe Cys Asp Gly Thr Thr Val
Val Val Thr Glu Asp Cys Gly Asn 1055 1060 1065 Arg Gly Pro Ser Leu
Arg Thr Thr Thr Ala Ser Gly Lys Leu Ile 1070 1075 1080 Thr Glu Trp
Cys Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg Tyr 1085 1090 1095 Arg
Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Leu 1100 1105
1110 Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala Gly
1115 1120 1125 His Gly Gln Val Asp Asn Phe Ser Leu Gly Val Leu Gly
Met Ala 1130 1135 1140 Leu Phe Leu Glu Glu Met Leu Arg Thr Arg Val
Gly Thr Lys His 1145 1150 1155 Ala Ile Leu Leu Val Ala Val Ser Phe
Val Thr Leu Ile Thr Gly 1160 1165 1170 Asn Met Ser Phe Arg Asp Leu
Gly Arg Val Met Val Met Val Gly 1175 1180 1185 Ala Thr Met Thr Asp
Asp Ile Gly Met Gly Val Thr Tyr Leu Ala 1190 1195 1200 Leu Leu Ala
Ala Phe Lys Val Arg Pro Thr Phe Ala Ala Gly Leu 1205 1210 1215 Leu
Leu Arg Lys Leu Thr Ser Lys Glu Leu Met Met Thr Thr Ile 1220 1225
1230 Gly Ile Val Leu Leu Ser Gln Ser Thr Ile Pro Glu Thr Ile Leu
1235 1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly Met Met Val Leu
Lys Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr Gln Leu Ala Val
Thr Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro Asn Ala Val Ile
Leu Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys Thr Ile Leu Ala
Val Val Ser Val Ser Pro Leu Leu 1295 1300 1305 Leu Thr Ser Ser Gln
Gln Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315 1320 Thr Ile Lys
Gly Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu 1325 1330 1335 Ser
Arg Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile 1340 1345
1350 Met Ala Val Gly Met Val Ser Ile Leu Ala Ser Ser Leu Leu Lys
1355 1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu Val Ala Gly Gly
Leu Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr Gly Arg Ser Ala
Asp Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp Val Lys Trp Glu
Asp Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser Pro Ile Leu Ser
Ile Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met Ser Ile Lys Asn
Glu Glu Glu Glu Gln Thr Leu Thr Ile Leu 1430 1435 1440 Ile Arg Thr
Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser 1445 1450 1455 Ile
Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys 1460 1465
1470 Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro Pro Met
1475 1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala Tyr Arg Ile Lys
Gln Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln Ile Gly Ala Gly
Val Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr Met Trp His Val
Thr Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys Gly Lys Arg Ile
Glu Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys Asp Leu Ile Ser
Tyr Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555 1560 Trp Lys Glu
Gly Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly 1565 1570 1575 Lys
Asn Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe Lys Thr 1580 1585
1590 Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp Phe Ser Pro Gly
1595 1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly Lys Val
Val Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val Thr Arg Ser Gly
Ala Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr Glu Lys Ser Ile
Glu Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp Ile Phe Arg Lys
Arg Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His Pro Gly Ala Gly
Lys Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675 1680 Arg Glu Ala
Ile Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro 1685 1690 1695 Thr
Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu 1700 1705
1710 Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala Val His Thr Gly
1715 1720 1725 Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe Thr
Met Arg 1730 1735 1740 Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn
Leu Ile Ile Met 1745 1750 1755 Asp Glu Ala His Phe Thr Asp Pro Ala
Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser Thr Arg Val Glu
Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met Thr Ala Thr Pro
Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795 1800 Asn Ala Pro
Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser 1805 1810 1815 Trp
Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly Lys Thr 1820 1825
1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala Ala
1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val Ile Gln Leu Ser
Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val Lys Thr Arg Thr
Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr Asp Ile Ser Glu
Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg Val Ile Asp Pro
Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu Thr Asp Gly Glu
Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915 1920 Val Thr His
Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg 1925 1930 1935 Asn
Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly Glu Pro 1940 1945
1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys Glu Ala Lys Met
1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile Pro
Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys Val Asp Ala Ile
Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu Ala Arg Lys Thr
Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp Leu Pro Val Trp
Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly Ile Asn Tyr Ala
Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035 2040 Asn Asn Gln
Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr 2045 2050 2055 Lys
Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala 2060 2065
2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu Phe
2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu Asn Leu Ile Thr
Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met Thr Gln Lys Ala
Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val Leu His Thr Ala
Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His Ala Leu Ser Glu
Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu Leu Leu Thr Leu
Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155 2160 Phe Leu Met
Ser Gly Arg Gly Ile Gly Lys Met Thr Leu Gly Met 2165 2170 2175 Cys
Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala Gln Ile 2180 2185
2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu Glu Phe Phe Leu
2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg Thr
Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val Val Ile Ala Ile
Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala Asn Glu Met Gly
Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu Gly Leu Gly Ser
Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn Ile Leu Asp Ile
Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275 2280 Tyr Ala Val
Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser 2285 2290
2295 Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile Ala Asn
2300 2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly Trp Pro
Leu Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu Ala Ile
Gly Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu Thr Ala
Ala Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile Ile Gly
Pro Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala Gln Lys
Arg Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr Val Asp
Gly Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395 2400 Asp
Pro Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val 2405 2410
2415 Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp Ala Leu
2420 2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile Ser Thr
Leu Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn Thr Thr
Ile Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly Ser Tyr
Leu Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met Lys Asn
Thr Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile Gly Glu
Thr Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn Ala Leu
Gly Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515 2520 Ile
Gln Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg 2525 2530
2535 Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala Lys Leu
2540 2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro Glu Gly
Lys Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser
Tyr Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu Val Lys
Gly Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu Pro Ile
Pro Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg Leu Gln
Ser Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu Lys Cys
Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635 2640 Asn
Pro Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu 2645 2650
2655 Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile Lys Val
2660 2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys Met Glu
Ala Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val Arg Asn
Pro Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr Trp Val
Ser Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val Asn Met
Ile Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met Arg Tyr
Lys Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu Gly Ser
Gly Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755 2760 Asn
Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu 2765 2770
2775 His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr Lys Thr
2780 2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly
Ser Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg Leu Leu
Thr Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr Gln Met
Ala Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln Arg Val
Phe Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu Pro Lys
Glu Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala Glu Trp
Leu Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875 2880 Met
Cys Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 2885 2890
2895 Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys Ser Ala
2900 2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu Leu Val
Asp Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys Cys Glu
Thr Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu Lys Lys
Leu Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg Ala Ile
Trp Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu Phe Glu
Ala Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe Ser Arg
Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995 3000 His
Lys Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly 3005 3010
3015 Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile
3020 3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val Thr Asn
His Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu Ala Ile
Phe Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg Val Gln
Arg Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile Ile Ser
Arg Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly Thr Tyr
Gly Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln Leu Ile
Arg Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115 3120 Gln
His Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu 3125 3130
3135 Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile Ser Gly
3140 3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg Phe Ala
Ser Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys Ile Arg
Lys Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly Trp Asn
Asp Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His Phe His
Glu Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val Val Pro
Cys Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala Arg Ile
Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235 3240 Cys
Leu Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe 3245 3250
3255 His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala
3260 3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr Thr Trp
Ser Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr Glu Asp
Met Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln Glu Asn
Pro Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser Trp Glu
Glu Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln Trp Cys
Gly Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr Trp Ala
Lys Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355 3360 Leu
Ile Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys 3365 3370
3375 Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp 3380 3385
3390 3210723DNAArtificial SequenceDerived from Dengue virus
serotype 2/Dengue virus serotype 4, DenVax-4j 32agttgttagt
ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta 60gttctaacag
ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg
120aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac
tgtgcaacag 180ctgacaaaga gattctcact tggaatgctg cagggacgag
gaccattaaa actgttcatg 240gccctggtgg cgttccttcg tttcctaaca
atcccaccaa cagcagggat attgaagaga 300tggggaacaa ttaaaaaatc
aaaagctatt aatgttttga gagggttcag gaaagagatt 360ggaaggatgc
tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg
420attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct
catgatagtg 480gcaaaacatg aaagggggag acctctcttg tttaagacaa
cagaggggat caacaaatgc 540actctcattg ccatggactt gggtgaaatg
tgtgaggaca ctgtcacgta taaatgcccc 600ttactggtca ataccgaacc
tgaagacatt gattgctggt gcaatctcac gtctacctgg 660gtcatgtatg
ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct
720ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat
gtcatcggaa 780ggggcttgga agcatgctca gagagtagag agctggatac
tcagaaaccc aggattcgcg 840ctcttggcag gatttatggc ttatatgatt
gggcaaacag gaatccagcg aactgtcttc 900tttgtcctaa tgatgctggt
cgccccatcc tacggaatgc gatgcgtagg agtaggaaac 960agagactttg
tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga
1020ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact
gactaagaca 1080acagccaagg aagtggctct gttaagaacc tattgcattg
aagcctcaat atcaaacata 1140accacggcaa caagatgtcc aacgcaagga
gagccttatc taaaagagga acaagaccaa 1200cagtacattt gccggagaga
tgtggtagac agagggtggg gcaatggctg tggcttgttt 1260ggaaaaggag
gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat
1320ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa
tggagacacc 1380catgcagtag gaaatgacac gtccaatcat ggagttacag
ccacgataac tcccaggtca 1440ccatcggtgg aagtcaaatt gccggactat
ggagaactaa cactcgattg tgaacccagg 1500tctggaattg actttaatga
gatgattctg atgaaaatga aaaagaaaac atggcttgtg 1560cataagcaat
ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag
1620gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc
caagagacag 1680gatgtgacag tgctgggatc tcaggaagga gccatgcatt
ctgccctcgc tggagccaca 1740gaagtggact ccggtgatgg aaatcacatg
tttgcaggac atctcaagtg caaagtccgt 1800atggagaaat tgagaatcaa
gggaatgtca tacacgatgt gttcaggaaa gttctcaatt 1860gacaaagaga
tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt
1920gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga
aaaagtggtt 1980gggcgtatca tctcatccac ccctttggct gagaatacca
acagtgtaac caacatagag 2040ttagaacccc cctttgggga cagctacata
gtgataggtg ttggaaacag tgcattaaca 2100ctccattggt tcaggaaagg
gagttccatt ggcaagatgt ttgagtccac atacagaggt 2160gcaaaacgaa
tggccattct aggtgaaaca gcttgggatt ttggttccgt tggtggactg
2220ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac
aaccctgttt 2280ggaggagtct catggatgat tagaatccta attgggttcc
tagtgttgtg gattggcacg 2340aactcaagga acacttcaat ggctatgacg
tgcatagctg ccggcattgt gacactgtat 2400ttgggagtca tggtgcaggc
cgatagtggt tgcgttgtga gctggaaaaa caaagaactg 2460aaatgtggca
gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag
2520ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca
tgaagaggac 2580atttgtggaa tccgctcagt aacaagactg gagaatctga
tgtggaaaca aataacacca 2640gaattgaatc acattctatc agaaaatgag
gtgaagttaa ctattatgac aggagacatc 2700aaaggaatca tgcaggcagg
aaaacgatct ctgcggcctc agcccactga gctgaagtat 2760tcatggaaaa
catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt
2820ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg
gaattcgttg 2880gaagttgaag actatggctt tggagtattc accaccaata
tatggctaaa attgaaagaa 2940aaacaggatg tattctgcga ctcaaaactc
atgtcagcgg ccataaaaga caacagagcc 3000gtccatgccg atatgggtta
ttggatagaa agtgcactca atgacacatg gaagatagag 3060aaagcctctt
tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc
3120aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc
agtgtctcaa 3180cacaactata gaccaggcta ccatacacaa ataacaggac
catggcatct aggtaagctt 3240gagatggact ttgatttctg tgatggaaca
acagtggtag tgactgagga ctgcggaaat 3300agaggaccct ctttgagaac
aaccactgcc tctggaaaac tcataacaga atggtgctgc 3360cgatcttgca
cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg
3420gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt
cacagctgga 3480catgggcagg tcgacaactt ttcactagga gtcttgggaa
tggcattgtt cctggaggaa 3540atgcttagga cccgagtagg aacgaaacat
gcaatactac tagttgcagt ttcttttgtg 3600acattgatca cagggaacat
gtcctttaga gacctgggaa gagtgatggt tatggtaggc 3660gccactatga
cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc
3720aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc
caaggaattg 3780atgatgacta ctataggaat tgtactcctc tcccagagca
ccataccaga gaccattctt 3840gagttgactg atgcgttagc cttaggcatg
atggtcctca aaatggtgag aaatatggaa 3900aagtatcaat tggcagtgac
tatcatggct atcttgtgcg tcccaaacgc agtgatatta 3960caaaacgcat
ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc
4020ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat
caaaggtctc 4080aatccaacag ctatttttct aacaaccctc tcaagaacca
gcaagaaaag gagctggcca 4140ttaaatgagg ctatcatggc agtcgggatg
gtgagcattt tagccagttc tctcctaaaa 4200aatgatattc ccatgacagg
accattagtg gctggagggc tcctcactgt gtgctacgtg 4260ctcactggac
gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac
4320caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga
agatggtagc 4380atgtcgataa aaaatgaaga ggaagaacaa acactgacca
tactcattag aacaggattg 4440ctggtgatct caggactttt tcctgtatca
ataccaatca cggcagcagc atggtacctg 4500tgggaagtga agaaacaacg
ggccggagta ttgtgggatg ttccttcacc cccacccatg 4560ggaaaggctg
aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat
4620tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg
gcatgtcaca 4680cgtggcgctg ttctaatgca taaaggaaag aggattgaac
catcatgggc ggacgtcaag 4740aaagacctaa tatcatatgg aggaggctgg
aagttagaag gagaatggaa ggaaggagaa 4800gaagtccagg tattggcact
ggagcctgga aaaaatccaa gagccgtcca aacgaaacct 4860ggtcttttca
aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga
4920acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta
tggtaatggt 4980gttgttacaa ggagtggagc atatgtgagt gctatagccc
agactgaaaa aagcattgaa 5040gacaacccag agatcgaaga tgacattttc
cgaaagagaa gactgaccat catggacctc 5100cacccaggag cgggaaagac
gaagagatac cttccggcca tagtcagaga agctataaaa 5160cggggtttga
gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa
5220gcccttagag gacttccaat aagataccag accccagcca tcagagctgt
gcacaccggg 5280cgggagattg tggacctaat gtgtcatgcc acatttacca
tgaggctgct atcaccagtt 5340agagtgccaa actacaacct gattatcatg
gacgaagccc atttcacaga cccagcaagt 5400atagcagcta gaggatacat
ctcaactcga gtggagatgg gtgaggcagc tgggattttt 5460atgacagcca
ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata
5520gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg
ggtcacggat 5580tttaaaggga agactgtttg gttcgttcca agtataaaag
caggaaatga tatagcagct 5640tgcctgagga aaaatggaaa gaaagtgata
caactcagta ggaagacctt tgattctgag 5700tatgtcaaga ctagaaccaa
tgattgggac ttcgtggtta caactgacat ttcagaaatg 5760ggtgccaatt
tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata
5820ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac
ccactctagt 5880gcagcacaaa gaagagggag aataggaaga aatccaaaaa
atgagaatga ccagtacata 5940tacatggggg aacctctgga aaatgatgaa
gactgtgcac actggaaaga agctaaaatg 6000ctcctagata acatcaacac
gccagaagga atcattccta gcatgttcga accagagcgt 6060gaaaaggtgg
atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt
6120gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt
ggcagctgaa 6180ggcatcaact acgcagacag aaggtggtgt tttgatggag
tcaagaacaa ccaaatccta 6240gaagaaaacg tggaagttga aatctggaca
aaagaagggg aaaggaagaa attgaaaccc 6300agatggttgg atgctaggat
ctattctgac ccactggcgc taaaagaatt taaggaattt 6360gcagccggaa
gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc
6420ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca
cacggctgag 6480gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc
cggagaccct ggagacattg 6540cttttactga cacttctggc tacagtcacg
ggagggatct ttttattctt gatgagcgca 6600aggggcatag ggaagatgac
cctgggaatg tgctgcataa tcacggctag catcctccta 6660tggtacgcac
aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc
6720atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa
ccaactgacc 6780tacgttgtca tagccatcct cacagtggtg gccgcaacca
tggcaaacga gatgggtttc 6840ctagaaaaaa cgaagaaaga tctcggattg
ggaagcattg caacccagca acccgagagc 6900aacatcctgg acatagatct
acgtcctgca tcagcatgga cgctgtatgc cgtggccaca 6960acatttgtta
caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta
7020acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg
gccattgtca 7080aagatggaca tcggagttcc ccttctcgcc attggatgct
actcacaagt caaccccata 7140actctcacag cagctctttt cttattggta
gcacattatg ccatcatagg gccaggactc 7200caagcaaaag caaccagaga
agctcagaaa agagcagcgg cgggcatcat gaaaaaccca 7260actgtcgatg
gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa
7320aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt
gatgatgagg 7380actacatggg ctctgtgtga ggctttaacc ttagctaccg
ggcccatctc cacattgtgg
7440gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc
taacattttt 7500agagggagtt acttggccgg agctggactt ctcttttcta
ttatgaagaa cacaaccaac 7560acaagaaggg gaactggcaa cataggagag
acgcttggag agaaatggaa aagccgattg 7620aacgcattgg gaaaaagtga
attccagatc tacaagaaaa gtggaatcca ggaagtggat 7680agaaccttag
caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga
7740ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga
agggaaagta 7800gtggacctcg gttgtggcag aggaggctgg tcatactatt
gtggaggact aaagaatgta 7860agagaagtca aaggcctaac aaaaggagga
ccaggacacg aagaacccat ccccatgtca 7920acatatgggt ggaatctagt
gcgtcttcaa agtggagttg acgttttctt catcccgcca 7980gaaaagtgtg
acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa
8040gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa
caacactcaa 8100ttttgcataa aggttctcaa cccatatatg ccctcagtca
tagaaaaaat ggaagcacta 8160caaaggaaat atggaggagc cttagtgagg
aatccactct cacgaaactc cacacatgag 8220atgtactggg tatccaatgc
ttccgggaac atagtgtcat cagtgaacat gatttcaagg 8280atgttgatca
acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac
8340ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct
agatataatt 8400gggaaaagaa tagaaaaaat aaagcaagag catgaaacat
catggcacta tgaccaagac 8460cacccataca aaacgtgggc ataccatggt
agctatgaaa caaaacagac tggatcagca 8520tcatccatgg tcaacggagt
ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg 8580gtgacacaga
tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag
8640aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat
gaaaataaca 8700gcagagtggc tttggaaaga attagggaag aaaaagacac
ccaggatgtg caccagagaa 8760gaattcacaa gaaaggtgag aagcaatgca
gccttggggg ccatattcac tgatgagaac 8820aagtggaagt cggcacgtga
ggctgttgaa gatagtaggt tttgggagct ggttgacaag 8880gaaaggaatc
tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa
8940agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat
atggtacatg 9000tggcttggag cacgcttctt agagtttgaa gccctaggat
tcttaaatga agatcactgg 9060ttctccagag agaactccct gagtggagtg
gaaggagaag ggctgcacaa gctaggttac 9120attctaagag acgtgagcaa
gaaagaggga ggagcaatgt atgccgatga caccgcagga 9180tgggatacaa
gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg
9240gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca
aaacaaggtg 9300gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg
acatcatatc gagaagagac 9360caaagaggta gtggacaagt tggcacctat
ggactcaata ctttcaccaa tatggaagcc 9420caactaatca gacagatgga
gggagaagga gtctttaaaa gcattcagca cctaacaatc 9480acagaagaaa
tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga
9540atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt
cgcaagcgct 9600ttaacagctc taaatgacat gggaaagatt aggaaagaca
tacaacaatg ggaaccttca 9660agaggatgga atgattggac acaagtgccc
ttctgttcac accatttcca tgagttaatc 9720atgaaagacg gtcgcgtact
cgttgttcca tgtagaaacc aagatgaact gattggcaga 9780gcccgaatct
cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct
9840tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct
ggcggcaaat 9900gctatttgct cggcagtacc atcacattgg gttccaacaa
gtcgaacaac ctggtccata 9960catgctaaac atgaatggat gacaacggaa
gacatgctga cagtctggaa cagggtgtgg 10020attcaagaaa acccatggat
ggaagacaaa actccagtgg aatcatggga ggaaatccca 10080tacttgggga
aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc
10140acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat
aggcaatgaa 10200gaatacacag attacatgcc atccatgaaa agattcagaa
gagaagagga agaagcagga 10260gttctgtggt agaaagcaaa actaacatga
aacaaggcta gaagtcaggt cggattaagc 10320catagtacgg aaaaaactat
gctacctgtg agccccgtcc aaggacgtta aaagaagtca 10380ggccatcata
aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg
10440tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta
gtggactagc 10500ggttagagga gacccctccc ttacaaatcg cagcaacaat
gggggcccaa ggcgagatga 10560agctgtagtc tcgctggaag gactagaggt
tagaggagac ccccccgaaa caaaaaacag 10620catattgacg ctgggaaaga
ccagagatcc tgctgtctcc tcagcatcat tccaggcaca 10680gaacgccaga
aaatggaatg gtgctgttga atcaacaggt tct 10723333391PRTArtificial
SequenceDerived from Dengue virus serotype 2/Dengue virus serotype
4, DenVax-4j 33Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe
Asn Met Leu 1 5 10 15 Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln
Gln Leu Thr Lys Arg 20 25 30 Phe Ser Leu Gly Met Leu Gln Gly Arg
Gly Pro Leu Lys Leu Phe Met 35 40 45 Ala Leu Val Ala Phe Leu Arg
Phe Leu Thr Ile Pro Pro Thr Ala Gly 50 55 60 Ile Leu Lys Arg Trp
Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 65 70 75 80 Leu Arg Gly
Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 85 90 95 Arg
Arg Arg Ser Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 100 105
110 Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val
115 120 125 Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr
Glu Gly 130 135 140 Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly
Glu Met Cys Glu 145 150 155 160 Asp Thr Val Thr Tyr Lys Cys Pro Leu
Leu Val Asn Thr Glu Pro Glu 165 170 175 Asp Ile Asp Cys Trp Cys Asn
Leu Thr Ser Thr Trp Val Met Tyr Gly 180 185 190 Thr Cys Thr Gln Ser
Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala 195 200 205 Leu Thr Pro
His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp 210 215 220 Met
Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 225 230
235 240 Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala
Tyr 245 250 255 Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe
Val Leu Met 260 265 270 Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys
Val Gly Val Gly Asn 275 280 285 Arg Asp Phe Val Glu Gly Val Ser Gly
Gly Ala Trp Val Asp Leu Val 290 295 300 Leu Glu His Gly Gly Cys Val
Thr Thr Met Ala Gln Gly Lys Pro Thr 305 310 315 320 Leu Asp Phe Glu
Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu 325 330 335 Arg Thr
Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 340 345 350
Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 355
360 365 Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn
Gly 370 375 380 Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala
Lys Phe Ser 385 390 395 400 Cys Ser Gly Lys Ile Thr Gly Asn Leu Val
Gln Ile Glu Asn Leu Glu 405 410 415 Tyr Thr Val Val Val Thr Val His
Asn Gly Asp Thr His Ala Val Gly 420 425 430 Asn Asp Thr Ser Asn His
Gly Val Thr Ala Thr Ile Thr Pro Arg Ser 435 440 445 Pro Ser Val Glu
Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp 450 455 460 Cys Glu
Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys 465 470 475
480 Met Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu
485 490 495 Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His
Trp Asn 500 505 510 Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His
Ala Lys Arg Gln 515 520 525 Asp Val Thr Val Leu Gly Ser Gln Glu Gly
Ala Met His Ser Ala Leu 530 535 540 Ala Gly Ala Thr Glu Val Asp Ser
Gly Asp Gly Asn His Met Phe Ala 545 550 555 560 Gly His Leu Lys Cys
Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly 565 570 575 Met Ser Tyr
Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met 580 585 590 Ala
Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 595 600
605 Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys
610 615 620 Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala
Glu Asn 625 630 635 640 Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro
Pro Phe Gly Asp Ser 645 650 655 Tyr Ile Val Ile Gly Val Gly Asn Ser
Ala Leu Thr Leu His Trp Phe 660 665 670 Arg Lys Gly Ser Ser Ile Gly
Lys Met Phe Glu Ser Thr Tyr Arg Gly 675 680 685 Ala Lys Arg Met Ala
Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser 690 695 700 Val Gly Gly
Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe 705 710 715 720
Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val Ser Trp Met Ile Arg 725
730 735 Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg
Asn 740 745 750 Thr Ser Met Ala Met Thr Cys Ile Ala Ala Gly Ile Val
Thr Leu Tyr 755 760 765 Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys
Val Val Ser Trp Lys 770 775 780 Asn Lys Glu Leu Lys Cys Gly Ser Gly
Ile Phe Ile Thr Asp Asn Val 785 790 795 800 His Thr Trp Thr Glu Gln
Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 805 810 815 Leu Ala Ser Ala
Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 820 825 830 Arg Ser
Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 835 840 845
Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 850
855 860 Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu
Arg 865 870 875 880 Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr
Trp Gly Lys Ala 885 890 895 Lys Met Leu Ser Thr Glu Ser His Asn Gln
Thr Phe Leu Ile Asp Gly 900 905 910 Pro Glu Thr Ala Glu Cys Pro Asn
Thr Asn Arg Ala Trp Asn Ser Leu 915 920 925 Glu Val Glu Asp Tyr Gly
Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 930 935 940 Lys Leu Lys Glu
Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 945 950 955 960 Ala
Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 965 970
975 Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe
980 985 990 Ile Glu Val Lys Asn Cys His Trp Pro Lys Ser His Thr Leu
Trp Ser 995 1000 1005 Asn Gly Val Leu Glu Ser Glu Met Ile Ile Pro
Lys Asn Leu Ala 1010 1015 1020 Gly Pro Val Ser Gln His Asn Tyr Arg
Pro Gly Tyr His Thr Gln 1025 1030 1035 Ile Thr Gly Pro Trp His Leu
Gly Lys Leu Glu Met Asp Phe Asp 1040 1045 1050 Phe Cys Asp Gly Thr
Thr Val Val Val Thr Glu Asp Cys Gly Asn 1055 1060 1065 Arg Gly Pro
Ser Leu Arg Thr Thr Thr Ala Ser Gly Lys Leu Ile 1070 1075 1080 Thr
Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro Leu Arg Tyr 1085 1090
1095 Arg Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Leu
1100 1105 1110 Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr
Ala Gly 1115 1120 1125 His Gly Gln Val Asp Asn Phe Ser Leu Gly Val
Leu Gly Met Ala 1130 1135 1140 Leu Phe Leu Glu Glu Met Leu Arg Thr
Arg Val Gly Thr Lys His 1145 1150 1155 Ala Ile Leu Leu Val Ala Val
Ser Phe Val Thr Leu Ile Thr Gly 1160 1165 1170 Asn Met Ser Phe Arg
Asp Leu Gly Arg Val Met Val Met Val Gly 1175 1180 1185 Ala Thr Met
Thr Asp Asp Ile Gly Met Gly Val Thr Tyr Leu Ala 1190 1195 1200 Leu
Leu Ala Ala Phe Lys Val Arg Pro Thr Phe Ala Ala Gly Leu 1205 1210
1215 Leu Leu Arg Lys Leu Thr Ser Lys Glu Leu Met Met Thr Thr Ile
1220 1225 1230 Gly Ile Val Leu Leu Ser Gln Ser Thr Ile Pro Glu Thr
Ile Leu 1235 1240 1245 Glu Leu Thr Asp Ala Leu Ala Leu Gly Met Met
Val Leu Lys Met 1250 1255 1260 Val Arg Asn Met Glu Lys Tyr Gln Leu
Ala Val Thr Ile Met Ala 1265 1270 1275 Ile Leu Cys Val Pro Asn Ala
Val Ile Leu Gln Asn Ala Trp Lys 1280 1285 1290 Val Ser Cys Thr Ile
Leu Ala Val Val Ser Val Ser Pro Leu Phe 1295 1300 1305 Leu Thr Ser
Ser Gln Gln Lys Thr Asp Trp Ile Pro Leu Ala Leu 1310 1315 1320 Thr
Ile Lys Gly Leu Asn Pro Thr Ala Ile Phe Leu Thr Thr Leu 1325 1330
1335 Ser Arg Thr Ser Lys Lys Arg Ser Trp Pro Leu Asn Glu Ala Ile
1340 1345 1350 Met Ala Val Gly Met Val Ser Ile Leu Ala Ser Ser Leu
Leu Lys 1355 1360 1365 Asn Asp Ile Pro Met Thr Gly Pro Leu Val Ala
Gly Gly Leu Leu 1370 1375 1380 Thr Val Cys Tyr Val Leu Thr Gly Arg
Ser Ala Asp Leu Glu Leu 1385 1390 1395 Glu Arg Ala Ala Asp Val Lys
Trp Glu Asp Gln Ala Glu Ile Ser 1400 1405 1410 Gly Ser Ser Pro Ile
Leu Ser Ile Thr Ile Ser Glu Asp Gly Ser 1415 1420 1425 Met Ser Ile
Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr Ile Leu 1430 1435 1440 Ile
Arg Thr Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val Ser 1445 1450
1455 Ile Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys
1460 1465 1470 Gln Arg Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro
Pro Met 1475 1480 1485 Gly Lys Ala Glu Leu Glu Asp Gly Ala Tyr Arg
Ile Lys Gln Lys 1490 1495 1500 Gly Ile Leu Gly Tyr Ser Gln Ile Gly
Ala Gly Val Tyr Lys Glu 1505 1510 1515 Gly Thr Phe His Thr Met Trp
His Val Thr Arg Gly Ala Val Leu 1520 1525 1530 Met His Lys Gly Lys
Arg Ile Glu Pro Ser Trp Ala Asp Val Lys 1535 1540 1545 Lys Asp Leu
Ile Ser Tyr Gly Gly Gly Trp Lys Leu Glu Gly Glu 1550 1555 1560 Trp
Lys Glu Gly Glu Glu Val Gln Val Leu Ala Leu Glu Pro Gly 1565 1570
1575 Lys Asn Pro Arg Ala Val Gln Thr Lys Pro Gly Leu Phe Lys Thr
1580 1585 1590 Asn Ala Gly Thr Ile Gly Ala Val Ser Leu Asp Phe Ser
Pro Gly 1595 1600 1605 Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly
Lys Val Val Gly 1610 1615 1620 Leu Tyr Gly Asn Gly Val Val Thr Arg
Ser Gly Ala Tyr Val Ser 1625 1630 1635 Ala Ile Ala Gln Thr Glu Lys
Ser Ile Glu Asp Asn Pro Glu Ile 1640 1645 1650 Glu Asp Asp Ile Phe
Arg Lys Arg Arg Leu Thr Ile Met Asp Leu 1655 1660 1665 His Pro Gly
Ala Gly Lys Thr Lys Arg Tyr Leu Pro Ala Ile Val 1670 1675 1680 Arg
Glu Ala Ile Lys Arg Gly Leu Arg Thr Leu Ile Leu Ala Pro 1685 1690
1695 Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala Leu Arg Gly Leu
1700 1705 1710 Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala Val His
Thr Gly 1715 1720 1725 Arg Glu Ile Val Asp Leu Met Cys His Ala Thr
Phe Thr Met Arg 1730 1735 1740 Leu Leu Ser Pro Val Arg Val Pro Asn
Tyr
Asn Leu Ile Ile Met 1745 1750 1755 Asp Glu Ala His Phe Thr Asp Pro
Ala Ser Ile Ala Ala Arg Gly 1760 1765 1770 Tyr Ile Ser Thr Arg Val
Glu Met Gly Glu Ala Ala Gly Ile Phe 1775 1780 1785 Met Thr Ala Thr
Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser 1790 1795 1800 Asn Ala
Pro Ile Ile Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser 1805 1810 1815
Trp Asn Ser Gly His Glu Trp Val Thr Asp Phe Lys Gly Lys Thr 1820
1825 1830 Val Trp Phe Val Pro Ser Ile Lys Ala Gly Asn Asp Ile Ala
Ala 1835 1840 1845 Cys Leu Arg Lys Asn Gly Lys Lys Val Ile Gln Leu
Ser Arg Lys 1850 1855 1860 Thr Phe Asp Ser Glu Tyr Val Lys Thr Arg
Thr Asn Asp Trp Asp 1865 1870 1875 Phe Val Val Thr Thr Asp Ile Ser
Glu Met Gly Ala Asn Phe Lys 1880 1885 1890 Ala Glu Arg Val Ile Asp
Pro Arg Arg Cys Met Lys Pro Val Ile 1895 1900 1905 Leu Thr Asp Gly
Glu Glu Arg Val Ile Leu Ala Gly Pro Met Pro 1910 1915 1920 Val Thr
His Ser Ser Ala Ala Gln Arg Arg Gly Arg Ile Gly Arg 1925 1930 1935
Asn Pro Lys Asn Glu Asn Asp Gln Tyr Ile Tyr Met Gly Glu Pro 1940
1945 1950 Leu Glu Asn Asp Glu Asp Cys Ala His Trp Lys Glu Ala Lys
Met 1955 1960 1965 Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile
Pro Ser Met 1970 1975 1980 Phe Glu Pro Glu Arg Glu Lys Val Asp Ala
Ile Asp Gly Glu Tyr 1985 1990 1995 Arg Leu Arg Gly Glu Ala Arg Lys
Thr Phe Val Asp Leu Met Arg 2000 2005 2010 Arg Gly Asp Leu Pro Val
Trp Leu Ala Tyr Arg Val Ala Ala Glu 2015 2020 2025 Gly Ile Asn Tyr
Ala Asp Arg Arg Trp Cys Phe Asp Gly Val Lys 2030 2035 2040 Asn Asn
Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr 2045 2050 2055
Lys Glu Gly Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala 2060
2065 2070 Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu
Phe 2075 2080 2085 Ala Ala Gly Arg Lys Ser Leu Thr Leu Asn Leu Ile
Thr Glu Met 2090 2095 2100 Gly Arg Leu Pro Thr Phe Met Thr Gln Lys
Ala Arg Asp Ala Leu 2105 2110 2115 Asp Asn Leu Ala Val Leu His Thr
Ala Glu Ala Gly Gly Arg Ala 2120 2125 2130 Tyr Asn His Ala Leu Ser
Glu Leu Pro Glu Thr Leu Glu Thr Leu 2135 2140 2145 Leu Leu Leu Thr
Leu Leu Ala Thr Val Thr Gly Gly Ile Phe Leu 2150 2155 2160 Phe Leu
Met Ser Ala Arg Gly Ile Gly Lys Met Thr Leu Gly Met 2165 2170 2175
Cys Cys Ile Ile Thr Ala Ser Ile Leu Leu Trp Tyr Ala Gln Ile 2180
2185 2190 Gln Pro His Trp Ile Ala Ala Ser Ile Ile Leu Glu Phe Phe
Leu 2195 2200 2205 Ile Val Leu Leu Ile Pro Glu Pro Glu Lys Gln Arg
Thr Pro Gln 2210 2215 2220 Asp Asn Gln Leu Thr Tyr Val Val Ile Ala
Ile Leu Thr Val Val 2225 2230 2235 Ala Ala Thr Met Ala Asn Glu Met
Gly Phe Leu Glu Lys Thr Lys 2240 2245 2250 Lys Asp Leu Gly Leu Gly
Ser Ile Ala Thr Gln Gln Pro Glu Ser 2255 2260 2265 Asn Ile Leu Asp
Ile Asp Leu Arg Pro Ala Ser Ala Trp Thr Leu 2270 2275 2280 Tyr Ala
Val Ala Thr Thr Phe Val Thr Pro Met Leu Arg His Ser 2285 2290 2295
Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala Ile Ala Asn 2300
2305 2310 Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly Trp Pro Leu
Ser 2315 2320 2325 Lys Met Asp Ile Gly Val Pro Leu Leu Ala Ile Gly
Cys Tyr Ser 2330 2335 2340 Gln Val Asn Pro Ile Thr Leu Thr Ala Ala
Leu Phe Leu Leu Val 2345 2350 2355 Ala His Tyr Ala Ile Ile Gly Pro
Gly Leu Gln Ala Lys Ala Thr 2360 2365 2370 Arg Glu Ala Gln Lys Arg
Ala Ala Ala Gly Ile Met Lys Asn Pro 2375 2380 2385 Thr Val Asp Gly
Ile Thr Val Ile Asp Leu Asp Pro Ile Pro Tyr 2390 2395 2400 Asp Pro
Lys Phe Glu Lys Gln Leu Gly Gln Val Met Leu Leu Val 2405 2410 2415
Leu Cys Val Thr Gln Val Leu Met Met Arg Thr Thr Trp Ala Leu 2420
2425 2430 Cys Glu Ala Leu Thr Leu Ala Thr Gly Pro Ile Ser Thr Leu
Trp 2435 2440 2445 Glu Gly Asn Pro Gly Arg Phe Trp Asn Thr Thr Ile
Ala Val Ser 2450 2455 2460 Met Ala Asn Ile Phe Arg Gly Ser Tyr Leu
Ala Gly Ala Gly Leu 2465 2470 2475 Leu Phe Ser Ile Met Lys Asn Thr
Thr Asn Thr Arg Arg Gly Thr 2480 2485 2490 Gly Asn Ile Gly Glu Thr
Leu Gly Glu Lys Trp Lys Ser Arg Leu 2495 2500 2505 Asn Ala Leu Gly
Lys Ser Glu Phe Gln Ile Tyr Lys Lys Ser Gly 2510 2515 2520 Ile Gln
Glu Val Asp Arg Thr Leu Ala Lys Glu Gly Ile Lys Arg 2525 2530 2535
Gly Glu Thr Asp His His Ala Val Ser Arg Gly Ser Ala Lys Leu 2540
2545 2550 Arg Trp Phe Val Glu Arg Asn Met Val Thr Pro Glu Gly Lys
Val 2555 2560 2565 Val Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr
Tyr Cys Gly 2570 2575 2580 Gly Leu Lys Asn Val Arg Glu Val Lys Gly
Leu Thr Lys Gly Gly 2585 2590 2595 Pro Gly His Glu Glu Pro Ile Pro
Met Ser Thr Tyr Gly Trp Asn 2600 2605 2610 Leu Val Arg Leu Gln Ser
Gly Val Asp Val Phe Phe Ile Pro Pro 2615 2620 2625 Glu Lys Cys Asp
Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro 2630 2635 2640 Asn Pro
Thr Val Glu Ala Gly Arg Thr Leu Arg Val Leu Asn Leu 2645 2650 2655
Val Glu Asn Trp Leu Asn Asn Asn Thr Gln Phe Cys Ile Lys Val 2660
2665 2670 Leu Asn Pro Tyr Met Pro Ser Val Ile Glu Lys Met Glu Ala
Leu 2675 2680 2685 Gln Arg Lys Tyr Gly Gly Ala Leu Val Arg Asn Pro
Leu Ser Arg 2690 2695 2700 Asn Ser Thr His Glu Met Tyr Trp Val Ser
Asn Ala Ser Gly Asn 2705 2710 2715 Ile Val Ser Ser Val Asn Met Ile
Ser Arg Met Leu Ile Asn Arg 2720 2725 2730 Phe Thr Met Arg Tyr Lys
Lys Ala Thr Tyr Glu Pro Asp Val Asp 2735 2740 2745 Leu Gly Ser Gly
Thr Arg Asn Ile Gly Ile Glu Ser Glu Ile Pro 2750 2755 2760 Asn Leu
Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln Glu 2765 2770 2775
His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr Lys Thr 2780
2785 2790 Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly Ser
Ala 2795 2800 2805 Ser Ser Met Val Asn Gly Val Val Arg Leu Leu Thr
Lys Pro Trp 2810 2815 2820 Asp Val Val Pro Met Val Thr Gln Met Ala
Met Thr Asp Thr Thr 2825 2830 2835 Pro Phe Gly Gln Gln Arg Val Phe
Lys Glu Lys Val Asp Thr Arg 2840 2845 2850 Thr Gln Glu Pro Lys Glu
Gly Thr Lys Lys Leu Met Lys Ile Thr 2855 2860 2865 Ala Glu Trp Leu
Trp Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg 2870 2875 2880 Met Cys
Thr Arg Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 2885 2890 2895
Ala Leu Gly Ala Ile Phe Thr Asp Glu Asn Lys Trp Lys Ser Ala 2900
2905 2910 Arg Glu Ala Val Glu Asp Ser Arg Phe Trp Glu Leu Val Asp
Lys 2915 2920 2925 Glu Arg Asn Leu His Leu Glu Gly Lys Cys Glu Thr
Cys Val Tyr 2930 2935 2940 Asn Met Met Gly Lys Arg Glu Lys Lys Leu
Gly Glu Phe Gly Lys 2945 2950 2955 Ala Lys Gly Ser Arg Ala Ile Trp
Tyr Met Trp Leu Gly Ala Arg 2960 2965 2970 Phe Leu Glu Phe Glu Ala
Leu Gly Phe Leu Asn Glu Asp His Trp 2975 2980 2985 Phe Ser Arg Glu
Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu 2990 2995 3000 His Lys
Leu Gly Tyr Ile Leu Arg Asp Val Ser Lys Lys Glu Gly 3005 3010 3015
Gly Ala Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile 3020
3025 3030 Thr Leu Glu Asp Leu Lys Asn Glu Glu Met Val Thr Asn His
Met 3035 3040 3045 Glu Gly Glu His Lys Lys Leu Ala Glu Ala Ile Phe
Lys Leu Thr 3050 3055 3060 Tyr Gln Asn Lys Val Val Arg Val Gln Arg
Pro Thr Pro Arg Gly 3065 3070 3075 Thr Val Met Asp Ile Ile Ser Arg
Arg Asp Gln Arg Gly Ser Gly 3080 3085 3090 Gln Val Gly Thr Tyr Gly
Leu Asn Thr Phe Thr Asn Met Glu Ala 3095 3100 3105 Gln Leu Ile Arg
Gln Met Glu Gly Glu Gly Val Phe Lys Ser Ile 3110 3115 3120 Gln His
Leu Thr Ile Thr Glu Glu Ile Ala Val Gln Asn Trp Leu 3125 3130 3135
Ala Arg Val Gly Arg Glu Arg Leu Ser Arg Met Ala Ile Ser Gly 3140
3145 3150 Asp Asp Cys Val Val Lys Pro Leu Asp Asp Arg Phe Ala Ser
Ala 3155 3160 3165 Leu Thr Ala Leu Asn Asp Met Gly Lys Ile Arg Lys
Asp Ile Gln 3170 3175 3180 Gln Trp Glu Pro Ser Arg Gly Trp Asn Asp
Trp Thr Gln Val Pro 3185 3190 3195 Phe Cys Ser His His Phe His Glu
Leu Ile Met Lys Asp Gly Arg 3200 3205 3210 Val Leu Val Val Pro Cys
Arg Asn Gln Asp Glu Leu Ile Gly Arg 3215 3220 3225 Ala Arg Ile Ser
Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala 3230 3235 3240 Cys Leu
Gly Lys Ser Tyr Ala Gln Met Trp Ser Leu Met Tyr Phe 3245 3250 3255
His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala 3260
3265 3270 Val Pro Ser His Trp Val Pro Thr Ser Arg Thr Thr Trp Ser
Ile 3275 3280 3285 His Ala Lys His Glu Trp Met Thr Thr Glu Asp Met
Leu Thr Val 3290 3295 3300 Trp Asn Arg Val Trp Ile Gln Glu Asn Pro
Trp Met Glu Asp Lys 3305 3310 3315 Thr Pro Val Glu Ser Trp Glu Glu
Ile Pro Tyr Leu Gly Lys Arg 3320 3325 3330 Glu Asp Gln Trp Cys Gly
Ser Leu Ile Gly Leu Thr Ser Arg Ala 3335 3340 3345 Thr Trp Ala Lys
Asn Ile Gln Ala Ala Ile Asn Gln Val Arg Ser 3350 3355 3360 Leu Ile
Gly Asn Glu Glu Tyr Thr Asp Tyr Met Pro Ser Met Lys 3365 3370 3375
Arg Phe Arg Arg Glu Glu Glu Glu Ala Gly Val Leu Trp 3380 3385
3390
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