U.S. patent application number 14/714728 was filed with the patent office on 2015-11-12 for gip-based mixed agonists for treatment of metabolic disorders and obesity. The applicant listed for this patent is Indiana University Research and Technology Corporation. Invention is credited to Richard D. DiMARCHI, Tao MA.
Application Number | 20150322130 14/714728 |
Document ID | / |
Family ID | 41570802 |
Filed Date | 2015-11-12 |
United States Patent Application | 20150322130 |
Kind Code | A1 |
DiMARCHI; Richard D. ; et al. | November 12, 2015 |
Glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-1 activity are provided. Pharmaceutical compositions comprising such glucagon peptides and therapeutic methods of using such peptides are also provided.
Inventors: | DiMARCHI; Richard D.; (Carmel, IN) ; MA; Tao; (Bloomington, IN) | ||||||||||
Applicant: |
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Family ID: | 41570802 | ||||||||||
Appl. No.: | 14/714728 | ||||||||||
Filed: | May 18, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12999285 | Mar 14, 2011 | 9062124 | ||
PCT/US2009/047447 | Jun 16, 2009 | |||
14714728 | ||||
61073274 | Jun 17, 2008 | |||
61078171 | Jul 3, 2008 | |||
61090448 | Aug 20, 2008 | |||
61151349 | Feb 10, 2009 | |||
Current U.S. Class: | 514/5.3 ; 514/11.7; 514/7.2; 530/308 |
Current CPC Class: | A61P 31/10 20180101; A61K 38/26 20130101; A61P 1/00 20180101; A61P 3/00 20180101; A61P 3/04 20180101; A61K 47/60 20170801; A61P 3/10 20180101; A61K 38/00 20130101; A61P 31/00 20180101; A61P 43/00 20180101; C07K 14/605 20130101 |
International Class: | C07K 14/605 20060101 C07K014/605; A61K 47/48 20060101 A61K047/48; A61K 38/26 20060101 A61K038/26 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 267 <210> SEQ ID NO 1 <211> LENGTH: 29 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Wild type glucagon <400> SEQUENCE: 1 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15 Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 2
<211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (1)..(31) <223> OTHER
INFORMATION: GLP-1(7-37) <400> SEQUENCE: 2 His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala
Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25 30
<210> SEQ ID NO 3 <211> LENGTH: 30 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(1)..(30) <223> OTHER INFORMATION: GLP-1(7-36) amidated
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (30)..(30) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 3 His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe
Ile Ala Trp Leu Val Lys Gly Arg 20 25 30 <210> SEQ ID NO 4
<211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: mat_peptide
<222> LOCATION: (1)..(42) <223> OTHER INFORMATION:
gastric inhibitory polypeptide <400> SEQUENCE: 4 Tyr Ala Glu
Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile
His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 20 25
30 Lys Asn Asp Trp Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID
NO 5 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 61 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20. <400> SEQUENCE: 5
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 6 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 62 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20. <400>
SEQUENCE: 6 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu
Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn
Thr 20 25 <210> SEQ ID NO 7 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 63 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(16)
<223> OTHER INFORMATION: Lactam bridge between residues 12
and 16. <400> SEQUENCE: 7 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile
Ala Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 8 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 66 <400>
SEQUENCE: 8 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu
Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala
Gln 20 25 <210> SEQ ID NO 9 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 68 <400> SEQUENCE: 9
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 1 5
10 15 Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 10 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 69 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 10 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Lys 1 5 10 15 Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met
Asn Thr 20 25 <210> SEQ ID NO 11 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 84 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 11 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile
Cys Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 12 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 85 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (20kDa) covalently attached to Cysteine
<400> SEQUENCE: 12 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile Cys
Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 13 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 92 <400>
SEQUENCE: 13 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 14 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 93 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (17)..(21) <223> OTHER INFORMATION:
Lactam bridge between residues 17 and 21 <400> SEQUENCE: 14
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 20 25
<210> SEQ ID NO 15 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 95 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 15 His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala
Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 16 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 96 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 16 Tyr Ala Glu Gly Thr Phe Ile Ser Asp
Tyr Ser Ile Ala Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 17 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 97 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 17 His Ala Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 18
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 98
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 18 Tyr Ala Glu Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His
Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ
ID NO 19 <211> LENGTH: 42 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 99 <400> SEQUENCE: 19 Tyr Ala Glu Gly Thr Phe Ile Ser
Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe
Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu
Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO 20 <211>
LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 100 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <400>
SEQUENCE: 20 Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala
Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu
Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr
Gln 35 40 <210> SEQ ID NO 21 <211> LENGTH: 42
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 101 <400> SEQUENCE: 21
Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5
10 15 Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly
Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40
<210> SEQ ID NO 22 <211> LENGTH: 42 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 102 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 22 Tyr Xaa Glu Gly
Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His
Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30
Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO
23 <211> LENGTH: 42 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 104 <400> SEQUENCE: 23 Tyr Ala Pro Gly Thr Phe Ile Ser
Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe
Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu
Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO 24 <211>
LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 105 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: PEG (40kDa) attached to
Cysteine <400> SEQUENCE: 24 Tyr Ala Pro Gly Thr Phe Ile Ser
Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe
Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu
Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO 25 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 106 <400>
SEQUENCE: 25 Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala
Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 26 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 107 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 26 His Ser Gln Gly Thr Phe Ile Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile
Ala Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 27 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 108 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 27 His Ser Gln Gly Thr Phe
Ile Ser Asp Tyr Ser Lys Ala Leu Asp Glu 1 5 10 15 Ile His Gln Lys
Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 28
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 109
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 28 Tyr Ser Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His
Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ
ID NO 29 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 110 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 29
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25
<210> SEQ ID NO 30 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 111 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 30 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 31 <211> LENGTH: 24
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 113 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (1)..(1)
<223> OTHER INFORMATION: Xaa is 3-phenyllactic acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (11)..(15) <223> OTHER INFORMATION: Lactam bridge
between residues 11 and 15 <400> SEQUENCE: 31 Xaa Ile Ser Asp
Tyr Ser Ile Ala Met Asp Glu Ile His Gln Lys Asp 1 5 10 15 Phe Val
Asn Trp Leu Leu Ala Gln 20 <210> SEQ ID NO 32 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 114 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(1)..(1) <223> OTHER INFORMATION: Xaa is 3-phenyllactic acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (11)..(15) <223> OTHER INFORMATION: Lactam bridge
between residues 11 and 15 <400> SEQUENCE: 32 Xaa Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu Ile His Gln Lys Asp 1 5 10 15 Phe Val
Asn Trp Leu Leu Ala Gln 20 <210> SEQ ID NO 33 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 115 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 33 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 34 <211> LENGTH:
39 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 116 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 34 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 35 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 118 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 35 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 36 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 120 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 36 Tyr Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 37 <211> LENGTH:
29 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 124 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 37 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 38 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 125 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 38 Tyr Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 39
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 127
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 39 Tyr Ser Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 40 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 128 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 40 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 41 <211> LENGTH:
39 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 129 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 41 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Ile
Ala Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 42 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 139 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 42 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile
Ala Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 43 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 140 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 43 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 44 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 141 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residuess 16
and 20 <400> SEQUENCE: 44 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Met Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 45 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 142 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 45 Tyr Ala Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 46 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 143 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 46 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Arg Arg Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 47 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 144 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 47 Tyr Ala Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 48 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 145 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 48 Tyr Ala Gln Gly Thr Phe Ile Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 49 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 146 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 49 Tyr Ala Gln Gly Thr Phe Ile Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 50 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 147 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 50 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile
Ala Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 51 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 148 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 51 Tyr Ser Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile
Ala Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 52 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 149 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 52 Tyr Ala Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 53 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 150 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 53 Tyr Ser Gln Gly Thr Phe Ile Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 54 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 151 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 54 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile
Ala Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 55 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 152 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 55 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 56 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 154 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (1)..(1)
<223> OTHER INFORMATION: Xaa is hippuric acid <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 56 Xaa Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 57 <211> LENGTH:
39 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 155 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(16)
<223> OTHER INFORMATION: Lactam bridge between residues 12
and 16 <400> SEQUENCE: 57 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 58 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 156 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(24)
<223> OTHER INFORMATION: Lactam bridge between residues 20
and 24 <400> SEQUENCE: 58 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 59 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 157 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(28)
<223> OTHER INFORMATION: Lactam bridge between residues 24
and 28 <400> SEQUENCE: 59 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Glu Trp Leu Leu Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 60 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 158 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 60 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 61 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 162 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 61 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Tyr Tyr Leu Asp Glu 1 5 10 15 Gln Ala Val Lys Glu Phe Val
Asn Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 62 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 163 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 62 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 63 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 164 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 63 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 64
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 165
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 64 Tyr Xaa Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 65
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 166
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is d-alanine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 65 Tyr Xaa Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 66
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 167
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (17)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 17 and 20 <400> SEQUENCE: 66 Tyr Ser Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Glu Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 67 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 168 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(18)..(21) <223> OTHER INFORMATION: Lactam bridge between
residues 18 and 21 <400> SEQUENCE: 67 Tyr Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Lys Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 68 <211> LENGTH:
29 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 169 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 68 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 69 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 170 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 69 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 70 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 172 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 70
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 71 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 174 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 71 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 72 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 175 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 72 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 73 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 176 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 73 Tyr Xaa Gln Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 74 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 177 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 74 Tyr Xaa Gln Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 75
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 178
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 75 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 76 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 179 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 76
Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 77 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 182 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 77 Tyr Xaa Gln Gly Thr
Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 78
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 186
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 78 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Cys
Trp Leu Met Asn Gly 20 25 <210> SEQ ID NO 79 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 191 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <400>
SEQUENCE: 79 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 80 <211> LENGTH: 34 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 192 <400> SEQUENCE: 80 Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala Lys Glu 1 5 10 15 Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala Pro Pro 20 25 30
Pro Ser <210> SEQ ID NO 81 <211> LENGTH: 38 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 194 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 81 Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Glu 1 5 10 15 Ala Val
Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser 20 25 30
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 82 <211>
LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 197 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(13)..(17) <223> OTHER INFORMATION: Lactam bridge between
residues 13 and 17 <400> SEQUENCE: 82 Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala 1 5 10 15 Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 83 <211>
LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 198 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(1)..(1) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(15)..(19) <223> OTHER INFORMATION: Lactam bridge between
residues 15 and 19 <400> SEQUENCE: 83 Xaa Gln Gly Thr Phe Thr
Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln 1 5 10 15 Ala Ala Lys Glu
Phe Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 84
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 199
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 84 Tyr Xaa Gln Gly
Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 85
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 200
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 85 Tyr Xaa Gln
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln
Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 20 25
30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 86
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 201
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 86 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 87 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 202 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 87 Tyr Xaa Gln Gly Thr
Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 88
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 203
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 88 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Xaa Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 89 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 204 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 89 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Arg Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser Cys 35 40 <210> SEQ ID NO 90 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 205 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 90
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 91 <211> LENGTH: 43 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 206 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 91
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly
Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 35 40
<210> SEQ ID NO 92 <211> LENGTH: 43 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 207 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 92 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr
Gln Cys 35 40 <210> SEQ ID NO 93 <211> LENGTH: 43
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 208 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (43)..(43) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 93
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly
Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 35 40
<210> SEQ ID NO 94 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 209 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (9)..(12) <223> OTHER
INFORMATION: Lactam bridge between residues 9 and 12 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 94 Tyr Xaa Gln Gly Thr Phe
Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 95 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: CEX <400>
SEQUENCE: 95 Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 1 5 10
<210> SEQ ID NO 96 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(1)..(1) <223> OTHER INFORMATION: Xaa is any amino acid
<400> SEQUENCE: 96 Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro
Ser 1 5 10 <210> SEQ ID NO 97 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <400> SEQUENCE: 97 Lys Arg Asn Arg Asn Asn Ile
Ala 1 5 <210> SEQ ID NO 98 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<400> SEQUENCE: 98 Lys Arg Asn Arg 1 <210> SEQ ID NO 99
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-274
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 99
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 100 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-311 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 100 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 101 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-298 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 101 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 102 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-309 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 102 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 103 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-310 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 18 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 103 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 104 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-260 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 104 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 105
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-261
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 105 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 106 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-262 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 18 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 106 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 107
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-252
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 107 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 108 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-255 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: PEG (40kDa) attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 108 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 109 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-256 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 109 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 110 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-257 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 110 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 111 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-263 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 111 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
112 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-264 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <400> SEQUENCE: 112 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 113
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-265
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 113 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 114 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-266 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 114 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 115 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-267 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: 18 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 115 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 116 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-268 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (39)..(39) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 116 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 117
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-269
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 117 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 118 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-270 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (10)..(10) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 118 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 119 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-271 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: 18 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 119 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 120 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-272 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (39)..(39) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 120 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 121
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-275
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Orn
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 121 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 122 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-276 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is 2,4-diaminobutyric acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 122 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 123 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-277 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covalentaly attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 123
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 124 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-278 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 124 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 125 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-279 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 18 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 125
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 126 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-280 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 126 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 127
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-281
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 127
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 128 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-282 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (10)..(10) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (29)..(29) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 128 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO
129 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-283 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 129 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 130 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-284 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: 18 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 130 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 131 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-285 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 131 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 132 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-286 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 132
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 133 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-287 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 133 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 134 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-288 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 18 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 134
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 135 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-289 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 135 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 136
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-290
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 136 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 137
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-291
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 16 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 137 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 138
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-292
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 18 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 138 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 139
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-293
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 139
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 140 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-295 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 140 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 141 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-296 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 141 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 142
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-297
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 142 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met
Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 143 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-299 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 143 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met
Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 144 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-306 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 144 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 145
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-307
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 18 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 145 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 146 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-308 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 146 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
147 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-322 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
3-SH-propionic acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 147 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 148 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-323 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 8 Carbon fatty acyl group covalently
attached to Lysine <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 148 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
149 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-324 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 149 Tyr Xaa Gln Gly Thr
Phe Ser Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 150
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-325
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (7)..(7) <223> OTHER INFORMATION: Xaa is
2-aminobutyric acid <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 150 Tyr Xaa
Gln Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO
151 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-329 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 8
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 151 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 152 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-330 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 8 Carbon fatty acyl group covalently
attached to Lysine <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 152 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
153 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-331 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 153 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 154 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-333 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Xaa is d-Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to d-Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 154 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 155
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-334
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is d-Lysine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 155 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 156 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-335 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa
is d-Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 156 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 157 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-336 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa
is d-Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 157 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 158
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-337
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 158 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 159 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-338 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 159 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 160
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-339
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 160 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35
40 <210> SEQ ID NO 161 <211> LENGTH: 41 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-340 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (41)..(41) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 161 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID
NO 162 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-341 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (39)..(39) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 162 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 163
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-343
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 163 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID NO 164
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-344
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 164
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210>
SEQ ID NO 165 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-345 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 165 His Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 166
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-353
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 166 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 167
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-241
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 167 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Lys Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 168 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-242 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 168 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Xaa 1 5 10 15 Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 169 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-273 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (12)..(16) <223> OTHER
INFORMATION: Lactam bridge between residues 12 and 16 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 169 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 170 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <400> SEQUENCE: 170 Gly Pro Ser Ser Gly Ala Pro
Pro Pro Lys 1 5 10 <210> SEQ ID NO 171 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is Gly or a small, aliphatic or non-polar or slightly polar amino
acid <400> SEQUENCE: 171 Xaa Gly Pro Ser Ser Gly Ala Pro Pro
Pro Lys 1 5 10 <210> SEQ ID NO 172 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is Gly or a small, aliphatic or non-polar or slightly polar amino
acid <400> SEQUENCE: 172 Xaa Gly Pro Ser Ser Gly Ala Pro Pro
Pro Ser Lys 1 5 10 <210> SEQ ID NO 173 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synethic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-248 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 173 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 174
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-249
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 174
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5
10 15 Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 175 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-250 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 175 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 176
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-251
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 176 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 177 <211> LENGTH:
29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-258 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 177 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 178 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-259 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
C-terminal amidation <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 178 Tyr Xaa Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Ser 1 5 10 15 Gln Ala
Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ
ID NO 179 <211> LENGTH: 30 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequene <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 179 His Xaa Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Cys
Trp Leu Val Lys Gly Arg 20 25 30 <210> SEQ ID NO 180
<211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 24
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <400>
SEQUENCE: 180 Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala
Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe Val Xaa Trp Leu Leu
Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr
Gln 35 40 <210> SEQ ID NO 181 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 69 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalentaly linked to hydrophilic group
<400> SEQUENCE: 181 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 182 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 70 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa can be any
naturally occurring amino acid <400> SEQUENCE: 182 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15
Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Xaa 20 25
<210> SEQ ID NO 183 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 72 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <400> SEQUENCE: 183
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
184 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 75 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <400> SEQUENCE: 184 Tyr Xaa Glu
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln
Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25
30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 185
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Sythetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 76
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 185 Tyr Xaa Gln Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Xaa Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 186
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 77
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 186 Tyr Xaa Gln Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 187 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 78
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 187 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Xaa Trp Leu Met Asn Gly 20 25 <210> SEQ ID NO 188
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 87
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substitute amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 188 Tyr Xaa Gln Gly Thr Phe
Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 189 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 88
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 189 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 190 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 90
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 190 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 191 <211>
LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 93
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (43)..(43) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 191 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 20 25 30 Lys Asn
Trp Leu Lys His Asn Ile Thr Gln Xaa 35 40 <210> SEQ ID NO 192
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 99
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 192 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 193 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 100 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 193
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 194 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 101, 102, 103 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substitute amino acid covalently linked to an acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 194 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 195
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
104, 105, 106 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to an acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 195 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 196 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 108 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 196
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 197 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 113, 114, 115 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 197 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 198 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 117, 118,
119 <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(39)..(39) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 198 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 199 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: SEQ ID NO: 123, 124, 125 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 199
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 200 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 127 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 200 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Xaa Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 201
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
128, 129, 130 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 201 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Xaa Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 202
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
132 <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 202 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 203 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 136, 137, 138 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 203
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 204 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 139 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 204 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys 35 40 <210> SEQ ID NO 205 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 140 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 205
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 206 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 141 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 206 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 207 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 142 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 207
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 208 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 143 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 208 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 209 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 144, 145 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to acyl or alkyl group <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 209 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40
<210> SEQ ID NO 210 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 148 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 210 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 211
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
152 <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 211 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 212 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 152 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 212
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 213 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 153 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 213 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys 35 40 <210> SEQ ID NO 214 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 154 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 214
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 215 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 156 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 215 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 216 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 157 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 216
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 217 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 235 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 217 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Xaa Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser 35 <210> SEQ ID NO 218 <211> LENGTH: 41
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 160 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 218
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa Cys 35 40 <210>
SEQ ID NO 219 <211> LENGTH: 39 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 162 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (10)..(10) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (39)..(39) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 219 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Xaa Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser 35 <210> SEQ ID NO 220 <211> LENGTH: 41
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 163 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (41)..(41) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 220 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Xaa Xaa 35 40 <210> SEQ ID
NO 221 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 164 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 221 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys Xaa 35 40 <210> SEQ ID NO 222 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 165
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 222 His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Cys
Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 223 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 166 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to acyl
or alkyl group <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 223 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO
224 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synethic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 173 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 224 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Lys Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 225 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 174 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 225
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5
10 15 Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 226 <211> LENGTH: 30 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequene <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 226 His Xaa Glu Gly Thr Phe
Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Ile Cys Trp Leu Val Lys Gly Arg 20 25 30 <210> SEQ ID
NO 227 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 227 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 228 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Ser, DAla, Val, Gly, N-Methyl Ser, N-Methyl Ala, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Lys,
Glu, Ser, Orn, Dab, Aib or any alpha, alpha-disubstituted amino
acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is any
alpha, alpha-disubstituted amino acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Ile, Leu, or Nle <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(28)..(28) <223> OTHER INFORMATION: Xaa is Ala or Gly
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa is Thr,
Ala, or Gly <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (29)..(29) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 228 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Xaa Xaa Xaa 20 25 <210> SEQ ID NO
229 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 229 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Lys 1 5 10 15 Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 230 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Ser, DAla, Val, Gly, N-Methyl Ser, N-Methyl Ala, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Lys,
Glu, Ser, Orn, Dab, Aib or any alpha, alpha-disubstituted amino
acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is any
alpha, alpha-disubstituted amino acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Ile, Leu, or Nle <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(28)..(28) <223> OTHER INFORMATION: Xaa is Ala or Gly
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa is Thr,
Ala, or Gly <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (29)..(29) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 230 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala
Xaa Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 20 25 <210> SEQ ID NO
231 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-354 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Homodimer <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covalently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <220> FEATURE:
<221> NAME/KEY: DISULFID <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: Disulfide bond formed with Cys
residue of a second peptide having the same structure. <400>
SEQUENCE: 231 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35
40 <210> SEQ ID NO 232 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Mt-356 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 232 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
233 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-357 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 233 Tyr Xaa Gln Gly Thr
Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 234
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Mt-358
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently bound to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 234 Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 235 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Mt-367 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently bound to Lysine
via a gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 235
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 236 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-368 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently bound to Lysine via a
gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 236
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 237 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-369 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently bound to Lysine via
gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 237
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 238 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-376 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Homodimer <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covelently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: C-terminal amidation <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: Cys residue covalently attached to
20 kDa PEG which is in turn covalently attached to a Cys residue of
a second peptide having the same structure <400> SEQUENCE:
238 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys
1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly
Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40
<210> SEQ ID NO 239 <211> LENGTH: 41 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Mt-377 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: homodimer <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty acyl
group covalently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: PEG (5kDa) covalently bound to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: C-terminal
amidation <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION: Cys
residue covalently attached to 5 kDa PEG which is in turn
covalently attached to a Cys residue of a second peptide having the
same structure <400> SEQUENCE: 239 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID NO 240
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Peptide J
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa is a
Glutamine analog <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa
is Nle <400> SEQUENCE: 240 His Ser Xaa Gly Thr Phe Thr Ser
Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe
Val Ala Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 241
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Peptide K
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa is a
Glutamine analog <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <400> SEQUENCE: 241 His Ser Xaa Gly Thr Phe Thr Ser
Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe
Val Ala Trp Leu Met Asp Glu 20 25 <210> SEQ ID NO 242
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 242 His Ser Gln
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg
Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210>
SEQ ID NO 243 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
Acetamidomethyl-cysteine <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (27)..(27) <223> OTHER
INFORMATION: Xaa is Nle <400> SEQUENCE: 243 His Ser Xaa Gly
Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg
Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210> SEQ
ID NO 244 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(3)
<223> OTHER INFORMATION: Xaa is Acetyldiaminobutanoic acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa is Nle
<400> SEQUENCE: 244 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala
Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 245 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is carbamoyldiaminopropanoic acid <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(27)..(27) <223> OTHER INFORMATION: Xaa is Nle <400>
SEQUENCE: 245 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa
Asp Glu 20 25 <210> SEQ ID NO 246 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa
is Methylglutamine <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (27)..(27) <223> OTHER
INFORMATION: Xaa is Nle <400> SEQUENCE: 246 His Ser Xaa Gly
Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg
Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210> SEQ
ID NO 247 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(3)
<223> OTHER INFORMATION: Xaa is Methionine sulfoxide
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa is Nle
<400> SEQUENCE: 247 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala
Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 248 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is Acetylornithine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 248
His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5
10 15 Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25
<210> SEQ ID NO 249 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is Aib <400>
SEQUENCE: 249 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met
Asp Glu 20 25 <210> SEQ ID NO 250 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa
is Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 250 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg
Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 20 25 <210>
SEQ ID NO 251 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is Methylglutamine
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 251 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe Val Ala
Trp Leu Met Asp Glu 20 25 <210> SEQ ID NO 252 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <400> SEQUENCE: 252 His Ser Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15 Arg Arg Ala
Gln Asp Phe Val Gln Trp Leu Met Asp Thr 20 25 <210> SEQ ID NO
253 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(3)
<223> OTHER INFORMATION: Xaa is Acetyldiaminobutanoic acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 253 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe Val Ala
Trp Leu Leu Asp Glu 20 25 <210> SEQ ID NO 254 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is Acetyldiaminobutanoic acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 254 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu
Asp Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 255 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 255 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg
Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 20 25 <210>
SEQ ID NO 256 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 256 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg
Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 20 25 <210>
SEQ ID NO 257 <400> SEQUENCE: 257 000 <210> SEQ ID NO
258 <400> SEQUENCE: 258 000 <210> SEQ ID NO 259
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-225
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
links Glu16 and Lys20 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Epsilon amine of Lys is attached to Ala-Ac- Cys(PEG),
wherein the Ac-Cys(PEG) is a Cys residue comprising an alpha amino
group capped with an acetyl group (CH3CO) and comprising a 40 kDa
PEG covalently attached to its side chain <400> SEQUENCE: 259
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 260 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-227 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge links Glu16 and Lys20 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Epsilon amine of Lys is attached to
Arg-Ac- Cys(PEG), wherein the Ac-Cys(PEG) is a Cys residue
comprising an alpha amino group capped with an acetyl group (CH3CO)
and comprising a 40 kDa PEG covalently attached to its side chain
<400> SEQUENCE: 260 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 261 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-294 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge links Glu16 and Lys20
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Cys-PEG
covalently linked via thioether linkage <400> SEQUENCE: 261
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 262 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 262
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 263 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (11)..(11)
<223> OTHER INFORMATION: Xaa is Ala or Gly <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(12)..(12) <223> OTHER INFORMATION: Xaa is Ala or Gly or is
absent <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is Ala or Gly or is absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa is Ala or Gly or is absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is Ala or Gly or is
absent <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Ala or Gly or is absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (17)..(17) <223>
OTHER INFORMATION: Xaa is Ala or Gly or is absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is Ala or Gly or is
absent <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is Ala or Gly or is absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Ala or Gly or is absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(21) <223> OTHER INFORMATION: Xaa is Ala or Gly or is
absent <400> SEQUENCE: 263 Gly Pro Ser Ser Gly Ala Pro Pro
Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa 20
<210> SEQ ID NO 264 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(12)..(12) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: May be absent <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(21) <223> OTHER INFORMATION: May be absent <400>
SEQUENCE: 264 Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Ala Ala Ala
Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala Ala 20 <210> SEQ ID NO
265 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 265 His
Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10
15 Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 266 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 266 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Ser 1 5 10 15 Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met
Asn Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 267 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(12)..(16) <223> OTHER INFORMATION: Lactam bridge between
residues 12 and 16 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 267 His Ser
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 20 25
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 267
<210> SEQ ID NO 1 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Wild type glucagon <400> SEQUENCE: 1 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15 Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 2
<211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (1)..(31) <223> OTHER
INFORMATION: GLP-1(7-37) <400> SEQUENCE: 2 His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala
Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25 30
<210> SEQ ID NO 3 <211> LENGTH: 30 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(1)..(30) <223> OTHER INFORMATION: GLP-1(7-36) amidated
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (30)..(30) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 3 His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe
Ile Ala Trp Leu Val Lys Gly Arg 20 25 30 <210> SEQ ID NO 4
<211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: mat_peptide
<222> LOCATION: (1)..(42) <223> OTHER INFORMATION:
gastric inhibitory polypeptide <400> SEQUENCE: 4 Tyr Ala Glu
Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile
His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 20 25
30 Lys Asn Asp Trp Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID
NO 5 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 61 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20. <400> SEQUENCE: 5
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 6 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 62 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20. <400>
SEQUENCE: 6 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu
Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn
Thr 20 25 <210> SEQ ID NO 7 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 63 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(16)
<223> OTHER INFORMATION: Lactam bridge between residues 12
and 16. <400> SEQUENCE: 7 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile
Ala Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 8 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 66 <400>
SEQUENCE: 8 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu
Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala
Gln 20 25 <210> SEQ ID NO 9 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 68 <400> SEQUENCE: 9
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 1 5
10 15 Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 10 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 69 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 10 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Lys 1 5 10 15 Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met
Asn Thr 20 25 <210> SEQ ID NO 11 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 84 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 11 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe Ile
Cys Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 12 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 85 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (20kDa) covalently attached to
Cysteine <400> SEQUENCE: 12 His Ser Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Glu Phe
Ile Cys Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 13
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 92
<400> SEQUENCE: 13 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Lys His Gln Lys Glu Phe Ile Ala
Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 14 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 93 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (17)..(21) <223> OTHER
INFORMATION: Lactam bridge between residues 17 and 21 <400>
SEQUENCE: 14 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 15 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 95 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 15 His Ala Glu Gly Thr Phe Ile Ser Asp
Tyr Ser Ile Ala Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 16 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 96 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 16 Tyr Ala Glu Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 17
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 97
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 17 His Ala Glu Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His
Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ
ID NO 18 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 98 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 18
Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5
10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25
<210> SEQ ID NO 19 <211> LENGTH: 42 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 99 <400> SEQUENCE: 19 Tyr Ala Glu Gly Thr
Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln
Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys
Asn Trp Leu Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO 20
<211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 100
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 20 Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr
Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe Val Asn
Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys His
Asn Ile Thr Gln 35 40 <210> SEQ ID NO 21 <211> LENGTH:
42 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 101 <400> SEQUENCE: 21
Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5
10 15 Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly
Lys 20 25 30 Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40
<210> SEQ ID NO 22 <211> LENGTH: 42 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 102 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 22 Tyr Xaa Glu Gly
Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His
Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30
Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40
<210> SEQ ID NO 23 <211> LENGTH: 42 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 104 <400> SEQUENCE: 23 Tyr Ala Pro Gly
Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His
Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30
Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO
24 <211> LENGTH: 42 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 105 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) attached to Cysteine <400> SEQUENCE: 24 Tyr Ala Pro
Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile
His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 20 25
30 Lys Asn Trp Leu Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID
NO 25 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 106 <400> SEQUENCE: 25 Tyr Ala Glu Gly Thr Phe Ile Ser
Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe
Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 26
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 107
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 26 His Ser Gln Gly
Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His
Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25 <210> SEQ
ID NO 27 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 108 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 27
His Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Ala Leu Asp Glu 1 5
10 15 Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 20 25
<210> SEQ ID NO 28 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 109 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 28 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 29 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 110 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 29 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 30 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 111 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 30 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys
Asp Phe Val Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 31
<211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 113
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa is
3-phenyllactic acid <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (11)..(15) <223> OTHER
INFORMATION: Lactam bridge between residues 11 and 15 <400>
SEQUENCE: 31 Xaa Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu Ile His
Gln Lys Asp 1 5 10 15 Phe Val Asn Trp Leu Leu Ala Gln 20
<210> SEQ ID NO 32 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 114 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa is 3-phenyllactic acid <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (11)..(15)
<223> OTHER INFORMATION: Lactam bridge between residues 11
and 15 <400> SEQUENCE: 32 Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu
Asp Glu Ile His Gln Lys Asp 1 5 10 15 Phe Val Asn Trp Leu Leu Ala
Gln 20 <210> SEQ ID NO 33 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 115 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20) <223>
OTHER INFORMATION: Lactam bridge between residues 16 and 20
<400> SEQUENCE: 33
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
34 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 116 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 34
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
35 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 118 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 35
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Ile His Gln Lys Glu Phe Val Asn Trp Leu Leu Ala Gln 20 25
<210> SEQ ID NO 36 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 120 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 36 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met
Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 37 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 124 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 37 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu
Ala Gln 20 25 <210> SEQ ID NO 38 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 125 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 38 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Met Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Val
Asn Trp Leu Leu Ala Gln 20 25 <210> SEQ ID NO 39 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 127 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 39 Tyr Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 40 <211> LENGTH:
39 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 128 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 40 His Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Ile
Ala Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 41 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 129 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 41 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Ile His Gln Lys Asp Phe Ile
Ala Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 42 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 139 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 42 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile
Ala Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 43 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 140 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 43
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
44 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 141 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residuess 16 and 20 <400> SEQUENCE: 44
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Met Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
45 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 142 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 45
Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
46 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 143 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 46
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Arg Arg Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
47 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 144 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 47
Tyr Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
48 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 145 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 48
Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
49 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 146 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 49
Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
50 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 147 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 50
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
51 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 148 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 51
Tyr Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
52 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 149 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 52
Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
53 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 150 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20) <223>
OTHER INFORMATION: Lactam bridge between residues 16 and 20
<400> SEQUENCE: 53 Tyr Ser Gln Gly Thr Phe Ile Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 54 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 151 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20) <223>
OTHER INFORMATION: Lactam bridge between residues 16 and 20
<400> SEQUENCE: 54 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 55 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 152 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 55 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 56 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 154 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa is hippuric acid <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20) <223>
OTHER INFORMATION: Lactam bridge between residues 16 and 20
<400> SEQUENCE: 56 Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 57 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 155 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(16) <223>
OTHER INFORMATION: Lactam bridge between residues 12 and 16
<400> SEQUENCE: 57 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 58 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 156 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(24) <223>
OTHER INFORMATION: Lactam bridge between residues 20 and 24
<400> SEQUENCE: 58 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Glu
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 59 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 157 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(28) <223>
OTHER INFORMATION: Lactam bridge between residues 24 and 28
<400> SEQUENCE: 59 Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Glu
Trp Leu Leu Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 60 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 158 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 60 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 61 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 162 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 61 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Val Lys Glu Phe Val Asn Trp Leu Ile
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 62 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 163 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 62
Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 63 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 164 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 63 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 64 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 165 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 64 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser Cys 35 40 <210> SEQ ID NO 65 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 166 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is d-alanine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 65 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 66 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 167 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(17)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 17 and 20 <400> SEQUENCE: 66 Tyr Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Glu Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 67 <211> LENGTH:
39 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 168 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (18)..(21)
<223> OTHER INFORMATION: Lactam bridge between residues 18
and 21 <400> SEQUENCE: 67 Tyr Ser Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Lys Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser 35 <210> SEQ ID NO 68 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 169 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 68 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 69 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 170 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 69 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 70 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 172 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 70
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 71 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 174 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 71 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser Cys 35 40 <210> SEQ ID NO 72 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 175 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 72
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
73 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 176 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 73
Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 74 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 177 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <400> SEQUENCE: 74
Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 75 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 178 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 75 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 76
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 179
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 76 Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Cys
Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 77 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 182 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 77 Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 78 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 186 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <400> SEQUENCE: 78
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Met Asn Gly
20 25 <210> SEQ ID NO 79 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Analog 191 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 79 Tyr Xaa Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 80 <211>
LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 192 <400>
SEQUENCE: 80 Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala
Ala Lys Glu 1 5 10 15 Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser
Ser Gly Ala Pro Pro 20 25 30 Pro Ser <210> SEQ ID NO 81
<211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 194
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 81 Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser
Ile Tyr Leu Asp Glu Glu 1 5 10 15 Ala Val Arg Leu Phe Val Asn Trp
Leu Leu Ala Gly Gly Pro Ser Ser 20 25 30 Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 82 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 197 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (13)..(17) <223> OTHER
INFORMATION: Lactam bridge between residues 13 and 17 <400>
SEQUENCE: 82 Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu
Gln Ala Ala 1 5 10 15 Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 83 <211> LENGTH: 28 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 198 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (15)..(19) <223> OTHER
INFORMATION: Lactam bridge between residues 15 and 19 <400>
SEQUENCE: 83 Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu
Asp Glu Gln 1 5 10 15 Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala
Gly 20 25 <210> SEQ ID NO 84 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 199 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 84 Tyr Xaa Gln Gly Thr Phe Val Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser Cys 35 40 <210> SEQ ID NO 85 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 200 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa
is Nle <400> SEQUENCE: 85 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Xaa Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro
Pro Ser Cys 35 40 <210> SEQ ID NO 86 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 201 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 86
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Glu Ala Val Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
87 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Analog 202 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <400> SEQUENCE: 87 Tyr Xaa Gln Gly Thr Phe Val Ser
Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40
<210> SEQ ID NO 88 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Analog 203 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(27)..(27) <223> OTHER INFORMATION: Xaa is Nle <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 88 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 89
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 204
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <400> SEQUENCE: 89 Tyr Xaa Glu Gly
Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala
Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 20 25 30
Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 90
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 205
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 90 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Arg Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 91 <211> LENGTH: 43
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Analog 206 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge between residues 16
and 20 <400> SEQUENCE: 91 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp
Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val
Asn Trp Leu Leu Ala Gly Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys
His Asn Ile Thr Gln Cys 35 40 <210> SEQ ID NO 92 <211>
LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 207 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge between
residues 16 and 20 <400> SEQUENCE: 92 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 20 25 30 Lys Asn
Trp Leu Lys His Asn Ile Thr Gln Cys 35 40 <210> SEQ ID NO 93
<211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Analog 208
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (43)..(43) <223>
OTHER INFORMATION: PEG (40kDa) covalently attached to Cysteine
<400> SEQUENCE: 93 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Lys Gly Lys 20 25 30 Lys Asn Trp Leu Lys His
Asn Ile Thr Gln Cys 35 40 <210> SEQ ID NO 94 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: Analog 209 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(9)..(12) <223> OTHER INFORMATION: Lactam bridge between
residues 9 and 12 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <400>
SEQUENCE: 94 Tyr Xaa Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 95 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: CEX <400> SEQUENCE: 95 Gly Pro Ser Ser Gly Ala
Pro Pro Pro Ser 1 5 10 <210> SEQ ID NO 96 <211> LENGTH:
11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is any amino acid <400> SEQUENCE: 96 Xaa Gly Pro Ser Ser Gly
Ala Pro Pro Pro Ser 1 5 10 <210> SEQ ID NO 97 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <400> SEQUENCE: 97 Lys Arg Asn Arg Asn
Asn Ile Ala 1 5 <210> SEQ ID NO 98 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <400> SEQUENCE: 98 Lys Arg Asn Arg 1 <210>
SEQ ID NO 99 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-274 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: PEG (40kDa) covalently attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 99 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 100 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-311 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 100 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 101
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-298
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 16 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 101 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 102
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-309
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 102 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 103
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-310
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 18 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 103 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys
35 40 <210> SEQ ID NO 104 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-260 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 104 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 105
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-261
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 105 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 106 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-262 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 18 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 106 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 107
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-252
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 107 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 108 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-255 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: PEG (40kDa) attached to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 108 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 109 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-256 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 109 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 110 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-257 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 110
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 111 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-263 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 111 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
112 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-264 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <400> SEQUENCE: 112 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 113
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-265
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 113 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 114 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-266 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 114 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 115 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-267 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: 18 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 115 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 116 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-268 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (39)..(39) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 116 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 117
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-269
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 117 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 118 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-270 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (10)..(10) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 118 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 119 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-271 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: 18 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 119 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 120 <211> LENGTH: 39 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-272 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (39)..(39) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 120 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 121
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-275
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Orn
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 121 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 122 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-276 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is 2,4-diaminobutyric acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 122 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 123 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-277 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covalentaly attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 123
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 124 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-278
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 124 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 125 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-279 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 18 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 125 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 126
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-280
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 126 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys 35 40 <210> SEQ ID NO 127 <211> LENGTH:
29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-281 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (29)..(29) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 127 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO
128 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-282 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 128 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 129 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-283 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: 16 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 129 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 130 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-284 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (10)..(10)
<223> OTHER INFORMATION: 18 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 130
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 131 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-285 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 131 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 132 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-286 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 132 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 133
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-287
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 133 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 134 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-288 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 18 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 134 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 135
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-289
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 135 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys 35 40 <210> SEQ ID NO 136 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-290 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 136 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 137 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-291 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 137 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 138 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-292 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 18
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 138 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 139 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-293 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 139 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 140
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-295
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 140
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 141 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-296 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 141 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 142 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-297 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 16 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 142
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 143 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-299 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 16 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 143
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 144 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-306 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 144 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 145 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-307 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 18 Carbon fatty acyl group
covalently attached to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 145
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 146 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-308 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 146 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 147
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-322
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 3-SH-propionic
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 147 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 148 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-323 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 8 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 148 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 149
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-324
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 149 Tyr Xaa Gln Gly Thr Phe Ser Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 150
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-325
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (7)..(7) <223> OTHER INFORMATION: Xaa is
2-aminobutyric acid <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 150 Tyr Xaa
Gln Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO
151 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-329 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION: 8
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 151 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 152 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-330 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 8 Carbon fatty acyl group covalently
attached to Lysine <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 152 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
153 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-331 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG
(40kDa) covalently attached to Cysteine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 153 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 154 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-333 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Xaa is d-Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to d-Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 154 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 155
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-334
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is d-Lysine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 155 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 156 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-335 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Xaa is d-Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 156 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 157
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-336
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Xaa is d-Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 157
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 158 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-337 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 158 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser 35 <210> SEQ ID NO 159 <211> LENGTH: 39 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-338 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 159 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 160
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-339
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty
acyl group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 160 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35
40 <210> SEQ ID NO 161 <211> LENGTH: 41 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-340 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (41)..(41) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 161 Tyr Xaa
Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID
NO 162 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-341 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 14
Carbon fatty acyl group covalently attached to Lysine <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 162 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 163 <211>
LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-343 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty acyl
group covalently attached to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 163 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID NO 164
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-344
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 164
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40 <210>
SEQ ID NO 165 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: mt-345 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 14 Carbon fatty acyl group covalently attached to
Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 165 His Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 166
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-353
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: 14 Carbon fatty acyl group covalently attached
to Lysine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 166 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 167
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-241
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 167 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Lys Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 168 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-242 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 168 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Xaa 1 5 10 15 Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys
35 40 <210> SEQ ID NO 169 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: mt-273 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (12)..(16) <223> OTHER
INFORMATION: Lactam bridge between residues 12 and 16 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 169 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Cys 35 40 <210> SEQ ID NO 170 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <400> SEQUENCE: 170 Gly Pro Ser Ser Gly Ala Pro
Pro Pro Lys 1 5 10 <210> SEQ ID NO 171 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is Gly or a small, aliphatic or non-polar or slightly polar amino
acid <400> SEQUENCE: 171 Xaa Gly Pro Ser Ser Gly Ala Pro Pro
Pro Lys 1 5 10 <210> SEQ ID NO 172 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is Gly or a small, aliphatic or non-polar or slightly polar amino
acid <400> SEQUENCE: 172 Xaa Gly Pro Ser Ser Gly Ala Pro Pro
Pro Ser Lys 1 5 10 <210> SEQ ID NO 173 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synethic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-248 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: PEG (40kDa) covalently attached to
Cysteine <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 173 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala
Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 174
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-249
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: PEG (40kDa)
covalently attached to Cysteine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 174
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5
10 15 Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ
ID NO 175 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-250 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 175 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Cys 35 40 <210> SEQ ID NO 176
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-251
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 176 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Cys 35 40 <210> SEQ ID NO 177 <211> LENGTH:
29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-258
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 177 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 178
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: mt-259
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: C-terminal amidation <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 178
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Ser 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 179 <211> LENGTH: 30 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequene <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: PEG (40kDa) covalently
attached to Cysteine <400> SEQUENCE: 179 His Xaa Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 1 5 10 15 Gln Ala Ala
Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg 20 25 30 <210>
SEQ ID NO 180 <211> LENGTH: 42 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 24 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 180 Tyr Ala Pro Gly Thr Phe
Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln
Asp Phe Val Xaa Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn
Trp Leu Lys His Asn Ile Thr Gln 35 40 <210> SEQ ID NO 181
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 69
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalentaly linked to
hydrophilic group <400> SEQUENCE: 181 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 182 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 70
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: Xaa can be any naturally occurring amino acid
<400> SEQUENCE: 182 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Xaa
Trp Leu Leu Ala Xaa 20 25 <210> SEQ ID NO 183 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 72
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 183 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 184 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 75
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 184 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40
<210> SEQ ID NO 185 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Sythetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 76 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <400> SEQUENCE: 185
Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 186 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 77 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <400> SEQUENCE: 186
Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 187 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 78 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <400> SEQUENCE: 187 Tyr Xaa Gln
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln
Ala Ala Lys Glu Phe Val Xaa Trp Leu Met Asn Gly 20 25 <210>
SEQ ID NO 188 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 87 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (16)..(20) <223> OTHER
INFORMATION: Lactam bridge between residues 16 and 20 <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Substitute amino acid
covalently linked to hydrophilic group <400> SEQUENCE: 188
Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 189 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 88 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge between residues 16 and 20 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Nle <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <400> SEQUENCE: 189 Tyr Xaa Gln
Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln
Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 20 25
30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 190
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 90
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 190 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 191 <211>
LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 93
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (16)..(20) <223> OTHER INFORMATION: Lactam bridge
between residues 16 and 20 <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (43)..(43) <223>
OTHER INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <400> SEQUENCE: 191 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 20 25 30 Lys Asn
Trp Leu Lys His Asn Ile Thr Gln Xaa 35 40 <210> SEQ ID NO
192
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 99
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 192 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 193 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 100 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 193
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 194 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 101, 102, 103 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to
hydrophilic group <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substitute amino acid covalently linked to an acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 194 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 195
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
104, 105, 106 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to an acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 195 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 196 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 108 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 196
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 197 <211> LENGTH: 39 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 113, 114, 115 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (24)..(24) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 197 Tyr Xaa Glu Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 198 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: SEQ ID NO: 117, 118, 119 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (10)..(10)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 198
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
199 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 123, 124, 125 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 199 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 200
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO:
127 <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 200 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 201 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 128, 129,
130 <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 201 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly 20 25 <210> SEQ ID NO 202 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 132
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 202 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 203 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 136, 137, 138 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 203
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 204 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 139 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (24)..(24) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 204 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 205 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 140 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 205
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 206 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 141 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 206 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 207 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 142 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 207
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 208 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 143 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 208 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Met Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 209 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 144, 145 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to acyl or alkyl group <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 209 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40
<210> SEQ ID NO 210 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 148 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to
acyl or alkyl group <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 210 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ ID NO
211 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 152 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 211 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 212 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 152 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 212
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 213 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 153 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 213 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Lys 35 40 <210> SEQ ID NO 214 <211> LENGTH:
40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 154 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 214
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 215 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 156 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 215 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 216 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 157 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (24)..(24)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 216 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 217 <211> LENGTH: 39
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 235 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (10)..(10)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 217
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
218 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 160 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to acyl or alkyl group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 218 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa Cys 35 40 <210> SEQ ID NO 219 <211>
LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 162
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (10)..(10) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Substituted amino acid
covalently linked to hydrophilic group <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 219 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35
<210> SEQ ID NO 220 <211> LENGTH: 41 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: SEQ ID NO: 163 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: Substituted amino acid covalently linked to acyl or
alkyl group <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 220 Tyr Xaa Glu Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa Xaa 35 40 <210> SEQ ID NO 221 <211>
LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: SEQ ID NO: 164
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to hydrophilic group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(41)..(41) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 221 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys Xaa 35 40 <210> SEQ ID NO 222 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 165 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to acyl or alkyl group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE:
222
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5
10 15 Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 223 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 166 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Substituted
amino acid covalently linked to acyl or alkyl group <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: C-terminal amidation
<400> SEQUENCE: 223 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Xaa
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Xaa 35 40 <210> SEQ ID NO 224 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synethic
polypeptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: SEQ ID NO: 173 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Substituted amino acid covalently
linked to hydrophilic group <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 224
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5
10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Xaa 35 40 <210> SEQ
ID NO 225 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
SEQ ID NO: 174 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 225 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Gln Glu Phe
Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro
Pro Pro Ser Xaa 35 40 <210> SEQ ID NO 226 <211> LENGTH:
30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequene
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION:
Substituted amino acid covalently linked to hydrophilic group
<400> SEQUENCE: 226 His Xaa Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Cys
Trp Leu Val Lys Gly Arg 20 25 30 <210> SEQ ID NO 227
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 227 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 20 25
<210> SEQ ID NO 228 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is D-Ser, DAla, Val,
Gly, N-Methyl Ser, N-Methyl Ala, or Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Lys, Glu, Ser, Orn, Dab, Aib
or any alpha, alpha-disubstituted amino acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is any alpha,
alpha-disubstituted amino acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Ile, Leu, or Nle <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (28)..(28)
<223> OTHER INFORMATION: Xaa is Ala or Gly <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: Xaa is Thr, Ala, or Gly
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 228 Tyr Xaa Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Ile Tyr Leu Asp Xaa 1 5 10 15 Gln Ala Ala Xaa Glu Phe
Val Asn Trp Leu Xaa Xaa Xaa 20 25 <210> SEQ ID NO 229
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 229 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Lys 1 5 10 15 Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Leu
Ala Gly 20 25 <210> SEQ ID NO 230 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Ser, DAla, Val, Gly, N-Methyl Ser, N-Methyl Ala, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Lys,
Glu, Ser, Orn, Dab, Aib or any alpha, alpha-disubstituted amino
acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is any
alpha, alpha-disubstituted amino acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Ile, Leu, or Nle <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(28)..(28) <223> OTHER INFORMATION: Xaa is Ala or Gly
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa is Thr,
Ala, or Gly <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (29)..(29) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 230 Tyr Xaa Gln Gly Thr
Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala
Xaa Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 20 25 <210> SEQ ID NO
231 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-354 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Homodimer <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covalently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <220> FEATURE:
<221> NAME/KEY: DISULFID <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: Disulfide bond formed with Cys
residue of a second peptide having the same structure. <400>
SEQUENCE: 231 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35
40 <210> SEQ ID NO 232 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <223>
OTHER INFORMATION: Mt-356 <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: C-terminal amidation <400> SEQUENCE: 232 Tyr Xaa
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15
Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO
233 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-357 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
C-terminal amidation <400> SEQUENCE: 233 Tyr Xaa Gln Gly Thr
Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala
Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser
Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 234
<211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Mt-358
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Aib
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: 16 Carbon fatty
acyl group covalently bound to Lysine <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 234 Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 235 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Mt-367 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently bound to Lysine
via a gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: C-terminal amidation <400>
SEQUENCE: 235 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 236 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Mt-368 <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (20)..(20) <223> OTHER
INFORMATION: Xaa is Aib <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (40)..(40) <223> OTHER
INFORMATION: 16 Carbon fatty acyl group covalently bound to Lysine
via a gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 236
Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 237 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-369 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: 16
Carbon fatty acyl group covalently bound to Lysine via
gamma-Glu-gamma-Glu spacer <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 237
Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 1 5
10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ
ID NO 238 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
Mt-376 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: Homodimer <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: 14 Carbon fatty acyl group
covelently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: C-terminal amidation <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41)
<223> OTHER INFORMATION: Cys residue covalently attached to
20 kDa PEG which is in turn covalently attached to a Cys residue of
a second peptide having the same structure <400> SEQUENCE:
238 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys
1 5 10 15 Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly
Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys Cys 35 40
<210> SEQ ID NO 239 <211> LENGTH: 41 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <223> OTHER
INFORMATION: Mt-377 <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: homodimer <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: 14 Carbon fatty acyl
group covalently bound to Lysine <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: PEG (5kDa) covalently bound to Cysteine
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: C-terminal
amidation <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION: Cys
residue covalently attached to 5 kDa PEG which is in turn
covalently attached to a Cys residue of a second peptide having the
same structure <400> SEQUENCE: 239 Tyr Xaa Glu Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 1 5 10 15 Gln Ala Ala Xaa
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Lys Cys 35 40 <210> SEQ ID NO 240
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Peptide J
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa is a
Glutamine analog <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa
is Nle <400> SEQUENCE: 240 His Ser Xaa Gly Thr Phe Thr Ser
Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe
Val Ala Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 241
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION: Peptide K
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa is a
Glutamine analog <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is Aib <400> SEQUENCE: 241 His Ser Xaa Gly Thr Phe Thr Ser
Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe
Val Ala Trp Leu Met Asp Glu 20 25
<210> SEQ ID NO 242 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(27)..(27) <223> OTHER INFORMATION: Xaa is Nle <400>
SEQUENCE: 242 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa
Asp Glu 20 25 <210> SEQ ID NO 243 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa
is Acetamidomethyl-cysteine <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 243 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg
Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210>
SEQ ID NO 244 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 244 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg
Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210>
SEQ ID NO 245 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
carbamoyldiaminopropanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (27)..(27) <223>
OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 245 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg
Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25 <210>
SEQ ID NO 246 <211> LENGTH: 29 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is Methylglutamine
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa is Nle
<400> SEQUENCE: 246 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala
Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 247 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is Methionine sulfoxide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa is Nle <400> SEQUENCE: 247
His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 1 5
10 15 Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 20 25
<210> SEQ ID NO 248 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is Acetylornithine
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa is Nle
<400> SEQUENCE: 248 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Thr 1 5 10 15 Arg Arg Ala Ala Glu Phe Val Ala
Trp Leu Xaa Asp Glu 20 25 <210> SEQ ID NO 249 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (16)..(16) <223> OTHER
INFORMATION: Xaa is Aib <400> SEQUENCE: 249 His Ser Gln Gly
Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg
Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 20 25 <210> SEQ
ID NO 250 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(3)
<223> OTHER INFORMATION: Xaa is Acetyldiaminobutanoic acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 250 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ala Asp Phe Val Ala
Trp Leu Met Asp Glu 20 25 <210> SEQ ID NO 251 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is Methylglutamine <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 251
His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5
10 15 Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 20 25
<210> SEQ ID NO 252 <211> LENGTH: 29 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <400>
SEQUENCE: 252 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Ser 1 5 10 15 Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met
Asp Thr 20 25 <210> SEQ ID NO 253 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa
is Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 253 His Ser Xaa
Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg
Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 20 25 <210>
SEQ ID NO 254 <211> LENGTH: 39 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(3)..(3) <223> OTHER INFORMATION: Xaa is
Acetyldiaminobutanoic acid <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: Xaa is Aib <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39) <223>
OTHER INFORMATION: C-terminal amidation <400> SEQUENCE: 254
His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5
10 15 Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro
Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO
255 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(3)
<223> OTHER INFORMATION: Xaa is Acetyldiaminobutanoic acid
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is Aib
<400> SEQUENCE: 255 His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Xaa 1 5 10 15 Arg Arg Ala Ser Asp Phe Val Ser
Trp Leu Leu Asp Glu 20 25 <210> SEQ ID NO 256 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is Acetyldiaminobutanoic acid <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Aib <400> SEQUENCE: 256
His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 1 5
10 15 Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 20 25
<210> SEQ ID NO 257 <400> SEQUENCE: 257 000 <210>
SEQ ID NO 258 <400> SEQUENCE: 258 000 <210> SEQ ID NO
259 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <223> OTHER INFORMATION:
mt-225 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is Aib <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (16)..(20) <223> OTHER INFORMATION:
Lactam bridge links Glu16 and Lys20 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Epsilon amine of Lys is attached to
Ala-Ac- Cys(PEG), wherein the Ac-Cys(PEG) is a Cys residue
comprising an alpha amino group capped with an acetyl group (CH3CO)
and comprising a 40 kDa PEG covalently attached to its side chain
<400> SEQUENCE: 259 Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn
Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro
Ser Lys 35 40 <210> SEQ ID NO 260 <211> LENGTH: 40
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<223> OTHER INFORMATION: mt-227 <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is Aib <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(20)
<223> OTHER INFORMATION: Lactam bridge links Glu16 and Lys20
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Epsilon amine
of Lys is attached to Arg-Ac- Cys(PEG), wherein the Ac-Cys(PEG) is
a Cys residue comprising an alpha amino group capped with an acetyl
group (CH3CO) and comprising a 40 kDa PEG covalently attached to
its side chain <400> SEQUENCE: 260 Tyr Xaa Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys
Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly
Ala Pro Pro Pro Ser Lys 35 40 <210> SEQ ID NO 261 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <223> OTHER INFORMATION: mt-294 <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(20) <223> OTHER INFORMATION: Lactam bridge links Glu16
and Lys20 <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (40)..(40) <223> OTHER INFORMATION:
Cys-PEG covalently linked via thioether linkage <400>
SEQUENCE: 261 Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr
Leu Asp Glu 1 5 10 15 Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu
Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Cys 35 40
<210> SEQ ID NO 262 <211> LENGTH: 40 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is Aib <400>
SEQUENCE: 262 His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr
Leu Asp Glu 1 5 10 15 Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met
Asn Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40
<210> SEQ ID NO 263 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is Ala or Gly <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (12)..(12) <223> OTHER
INFORMATION: Xaa is Ala or Gly or is absent <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (13)..(13)
<223> OTHER INFORMATION: Xaa is Ala or Gly or is absent
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (14)..(14) <223> OTHER INFORMATION: Xaa is Ala or
Gly or is absent <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (15)..(15) <223> OTHER
INFORMATION: Xaa is Ala or Gly or is absent <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is Ala or Gly or is absent
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is Ala or
Gly or is absent <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (18)..(18) <223> OTHER
INFORMATION: Xaa is Ala or Gly or is absent <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (19)..(19)
<223> OTHER INFORMATION: Xaa is Ala or Gly or is absent
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Ala or
Gly or is absent <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(21) <223> OTHER
INFORMATION: Xaa is Ala or Gly or is absent <400> SEQUENCE:
263 Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15 Xaa Xaa Xaa Xaa Xaa 20 <210> SEQ ID NO 264
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(12) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (13)..(13) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (15)..(15) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (16)..(16) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (17)..(17) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (18)..(18) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (19)..(19) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: May be absent <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(21) <223>
OTHER INFORMATION: May be absent <400> SEQUENCE: 264 Gly Pro
Ser Ser Gly Ala Pro Pro Pro Ser Ala Ala Ala Ala Ala Ala 1 5 10 15
Ala Ala Ala Ala Ala 20 <210> SEQ ID NO 265 <211>
LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 265 His Ser Gln Gly Thr Phe
Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15 Cys Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Thr 20 25 <210> SEQ ID NO 266
<211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 266 His Ser
Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 20
25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> SEQ ID NO 267
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (12)..(16) <223>
OTHER INFORMATION: Lactam bridge between residues 12 and 16
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: C-terminal
amidation <400> SEQUENCE: 267 His Ser Gln Gly Thr Phe Thr Ser
Asp Tyr Ser Lys Tyr Leu Asp Glu 1 5 10 15 Arg Arg Ala Gln Asp Phe
Val Gln Trp Leu Met Asn Thr 20 25
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