U.S. patent application number 14/798357 was filed with the patent office on 2015-11-05 for sumoylation of serca2a and cardiovascular disease. This patent application is currently assigned to Icahn School of Medicine at Mount Sinai. The applicant listed for this patent is Roger Joseph Hajjar, Chang Won Kho, Ah Young Lee. Invention is credited to Roger Joseph Hajjar, Chang Won Kho, Ah Young Lee.
Application Number | 20150316551 14/798357 |
Document ID | / |
Family ID | 47506595 |
Filed Date | 2015-11-05 |
United States Patent Application | 20150316551 |
Kind Code | A1 |
Hajjar; Roger Joseph ; et al. | November 5, 2015 |
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation.
Inventors: | Hajjar; Roger Joseph; (Tenafly, NJ) ; Kho; Chang Won; (New York, NY) ; Lee; Ah Young; (New York, NY) | ||||||||||
Applicant: |
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Assignee: | Icahn School of Medicine at Mount
Sinai New York NY |
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Family ID: | 47506595 | ||||||||||
Appl. No.: | 14/798357 | ||||||||||
Filed: | July 13, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14232105 | Apr 9, 2014 | |||
PCT/US12/46777 | Jul 13, 2012 | |||
14798357 | ||||
61507526 | Jul 13, 2011 | |||
Current U.S. Class: | 435/6.18 ; 435/18; 435/7.1 |
Current CPC Class: | C12Q 2600/136 20130101; G01N 2800/325 20130101; C12N 15/86 20130101; C12Y 305/00 20130101; A61K 31/7088 20130101; C12Q 2600/158 20130101; G01N 33/573 20130101; C12N 7/00 20130101; C12Q 1/6883 20130101; A61P 9/04 20180101; A61K 48/0066 20130101; G01N 2333/914 20130101; A61K 38/1709 20130101; A61K 38/50 20130101; G01N 2440/36 20130101; C12N 2750/14143 20130101 |
International Class: | G01N 33/573 20060101 G01N033/573; C12Q 1/68 20060101 C12Q001/68 |
Sequence CWU 1
1
1614359DNAHomo sapiensmisc_featureHuman SERCA2a polynucleotide
1ggcagcggcc gataaatgct attagagcag ccgccgcgga gccgtccccg acgccacctc
60cttttccttc gccgcagttt cctccgccgc tgtcgggcgt gcggcgctga gggacccggg
120cgagcgcgcc gcgcaccgcc ccgccggctc gcctccctcg ccgcgttccg
ccctcagtgg 180tctgccgggc gccccctcct ccggcccggg cggggcctct
gatcgcctca agagagcggg 240gagggggctc gggggccgcg gcctgccctc
ccggcgggcg gctgagggcg agggaggccc 300tcccttctgg cgaggggagg
gagggtgggt caggagcccc caacccgccc tgcggagctc 360ggggccgcgc
gaggggcggt tgtctggggg agggggcgcg gggtgattca gcgcccggcg
420aggcggaagc ggccgcaaga ggaggagggg agagcccgtc cgcgcctggg
ctcccggggt 480ggcacgagcc cgcggccgga gtgcgaggcg gaggcgagga
ggccgcgggg acgggaggcg 540aggccggccg ggcccccgaa gcc atg gag aac gcg
cac acc aag acg gtg gag 593 Met Glu Asn Ala His Thr Lys Thr Val Glu
1 5 10 gag gtg ctg ggc cac ttc ggc gtc aac gag agt acg ggg ctg agc
ctg 641Glu Val Leu Gly His Phe Gly Val Asn Glu Ser Thr Gly Leu Ser
Leu 15 20 25 gaa cag gtc aag aag ctt aag gag aga tgg ggc tcc aac
gag tta ccg 689Glu Gln Val Lys Lys Leu Lys Glu Arg Trp Gly Ser Asn
Glu Leu Pro 30 35 40 gct gaa gaa gga aaa acc ttg ctg gaa ctt gtg
att gag cag ttt gaa 737Ala Glu Glu Gly Lys Thr Leu Leu Glu Leu Val
Ile Glu Gln Phe Glu 45 50 55 gac ttg cta gtt agg att tta tta ctg
gca gca tgt ata tct ttt gtt 785Asp Leu Leu Val Arg Ile Leu Leu Leu
Ala Ala Cys Ile Ser Phe Val 60 65 70 ttg gct tgg ttt gaa gaa ggt
gaa gaa aca att aca gcc ttt gta gaa 833Leu Ala Trp Phe Glu Glu Gly
Glu Glu Thr Ile Thr Ala Phe Val Glu 75 80 85 90 cct ttt gta att tta
ctc ata tta gta gcc aat gca att gtg ggt gta 881Pro Phe Val Ile Leu
Leu Ile Leu Val Ala Asn Ala Ile Val Gly Val 95 100 105 tgg cag gaa
aga aat gct gaa aat gcc atc gaa gcc ctt aag gaa tat 929Trp Gln Glu
Arg Asn Ala Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr 110 115 120 gag
cct gaa atg ggc aaa gtg tat cga cag gac aga aag agt gtg cag 977Glu
Pro Glu Met Gly Lys Val Tyr Arg Gln Asp Arg Lys Ser Val Gln 125 130
135 cgg att aaa gct aaa gac ata gtt cct ggt gat att gta gaa att gct
1025Arg Ile Lys Ala Lys Asp Ile Val Pro Gly Asp Ile Val Glu Ile Ala
140 145 150 gtt ggt gac aaa gtt cct gct gat ata agg tta act tcc atc
aaa tct 1073Val Gly Asp Lys Val Pro Ala Asp Ile Arg Leu Thr Ser Ile
Lys Ser 155 160 165 170 acc aca cta aga gtt gac cag tca att ctc aca
ggt gaa tct gtc tct 1121Thr Thr Leu Arg Val Asp Gln Ser Ile Leu Thr
Gly Glu Ser Val Ser 175 180 185 gtc atc aag cac act gat ccc gtc cct
gac cca cga gct gtc aac caa 1169Val Ile Lys His Thr Asp Pro Val Pro
Asp Pro Arg Ala Val Asn Gln 190 195 200 gat aaa aag aac atg ctg ttt
tct ggt aca aac att gct gct ggg aaa 1217Asp Lys Lys Asn Met Leu Phe
Ser Gly Thr Asn Ile Ala Ala Gly Lys 205 210 215 gct atg gga gtg gtg
gta gca act gga gtt aac acc gaa att ggc aag 1265Ala Met Gly Val Val
Val Ala Thr Gly Val Asn Thr Glu Ile Gly Lys 220 225 230 atc cgg gat
gaa atg gtg gca aca gaa cag gag aga aca ccc ctt cag 1313Ile Arg Asp
Glu Met Val Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln 235 240 245 250
caa aaa cta gat gaa ttt ggg gaa cag ctt tcc aaa gtc atc tcc ctt
1361Gln Lys Leu Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu
255 260 265 att tgc att gca gtc tgg atc ata aat att ggg cac ttc aat
gac ccg 1409Ile Cys Ile Ala Val Trp Ile Ile Asn Ile Gly His Phe Asn
Asp Pro 270 275 280 gtt cat gga ggg tcc tgg atc aga ggt gct att tac
tac ttt aaa att 1457Val His Gly Gly Ser Trp Ile Arg Gly Ala Ile Tyr
Tyr Phe Lys Ile 285 290 295 gca gtg gcc ctg gct gta gca gcc att cct
gaa ggt ctg cct gca gtc 1505Ala Val Ala Leu Ala Val Ala Ala Ile Pro
Glu Gly Leu Pro Ala Val 300 305 310 atc acc acc tgc ctg gct ctt gga
act cgc aga atg gca aag aaa aat 1553Ile Thr Thr Cys Leu Ala Leu Gly
Thr Arg Arg Met Ala Lys Lys Asn 315 320 325 330 gcc att gtt cga agc
ctc ccg tct gtg gaa acc ctt ggt tgt act tct 1601Ala Ile Val Arg Ser
Leu Pro Ser Val Glu Thr Leu Gly Cys Thr Ser 335 340 345 gtt atc tgc
tca gac aag act ggt aca ctt aca aca aac cag atg tca 1649Val Ile Cys
Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Gln Met Ser 350 355 360 gtc
tgc agg atg ttc att ctg gac aga gtg gaa ggt gat act tgt tcc 1697Val
Cys Arg Met Phe Ile Leu Asp Arg Val Glu Gly Asp Thr Cys Ser 365 370
375 ctt aat gag ttt acc ata act gga tca act tat gca cct att gga gaa
1745Leu Asn Glu Phe Thr Ile Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu
380 385 390 gtg cat aaa gat gat aaa cca gtg aat tgt cac cag tat gat
ggt ctg 1793Val His Lys Asp Asp Lys Pro Val Asn Cys His Gln Tyr Asp
Gly Leu 395 400 405 410 gta gaa tta gca aca att tgt gct ctt tgt aat
gac tct gct ttg gat 1841Val Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn
Asp Ser Ala Leu Asp 415 420 425 tac aat gag gca aag ggt gtg tat gaa
aaa gtt gga gaa gct aca gag 1889Tyr Asn Glu Ala Lys Gly Val Tyr Glu
Lys Val Gly Glu Ala Thr Glu 430 435 440 act gct ctc act tgc cta gta
gag aag atg aat gta ttt gat acc gaa 1937Thr Ala Leu Thr Cys Leu Val
Glu Lys Met Asn Val Phe Asp Thr Glu 445 450 455 ttg aag ggt ctt tct
aaa ata gaa cgt gca aat gcc tgc aac tca gtc 1985Leu Lys Gly Leu Ser
Lys Ile Glu Arg Ala Asn Ala Cys Asn Ser Val 460 465 470 att aaa cag
ctg atg aaa aag gaa ttc act cta gag ttt tca cgt gac 2033Ile Lys Gln
Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp 475 480 485 490
aga aag tca atg tcg gtt tac tgt aca cca aat aaa cca agc agg aca
2081Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr
495 500 505 tca atg agc aag atg ttt gtg aag ggt gct cct gaa ggt gtc
att gac 2129Ser Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val
Ile Asp 510 515 520 agg tgc acc cac att cga gtt gga agt act aag gtt
cct atg acc tct 2177Arg Cys Thr His Ile Arg Val Gly Ser Thr Lys Val
Pro Met Thr Ser 525 530 535 gga gtc aaa cag aag atc atg tct gtc att
cga gag tgg ggt agt ggc 2225Gly Val Lys Gln Lys Ile Met Ser Val Ile
Arg Glu Trp Gly Ser Gly 540 545 550 agc gac aca ctg cga tgc ctg gcc
ctg gcc act cat gac aac cca ctg 2273Ser Asp Thr Leu Arg Cys Leu Ala
Leu Ala Thr His Asp Asn Pro Leu 555 560 565 570 aga aga gaa gaa atg
cac ctt gag gac tct gcc aac ttt att aaa tat 2321Arg Arg Glu Glu Met
His Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr 575 580 585 gag acc aat
ctg acc ttc gtt ggc tgc gtg ggc atg ctg gat cct ccg 2369Glu Thr Asn
Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro 590 595 600 aga
atc gag gtg gcc tcc tcc gtg aag ctg tgc cgg caa gca ggc atc 2417Arg
Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly Ile 605 610
615 cgg gtc atc atg atc act ggg gac aac aag ggc act gct gtg gcc atc
2465Arg Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile
620 625 630 tgt cgc cgc atc ggc atc ttc ggg cag gat gag gac gtg acg
tca aaa 2513Cys Arg Arg Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Thr
Ser Lys 635 640 645 650 gct ttc aca ggc cgg gag ttt gat gaa ctc aac
ccc tcc gcc cag cga 2561Ala Phe Thr Gly Arg Glu Phe Asp Glu Leu Asn
Pro Ser Ala Gln Arg 655 660 665 gac gcc tgc ctg aac gcc cgc tgt ttt
gct cga gtt gaa ccc tcc cac 2609Asp Ala Cys Leu Asn Ala Arg Cys Phe
Ala Arg Val Glu Pro Ser His 670 675 680 aag tct aaa atc gta gaa ttt
ctt cag tct ttt gat gag att aca gct 2657Lys Ser Lys Ile Val Glu Phe
Leu Gln Ser Phe Asp Glu Ile Thr Ala 685 690 695 atg act ggc gat ggc
gtg aac gat gct cct gct ctg aag aaa gcc gag 2705Met Thr Gly Asp Gly
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu 700 705 710 att ggc att
gct atg ggc tct ggc act gcg gtg gct aaa acc gcc tct 2753Ile Gly Ile
Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser 715 720 725 730
gag atg gtc ctg gcg gat gac aac ttc tcc acc att gtg gct gcc gtt
2801Glu Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val
735 740 745 gag gag ggg cgg gca atc tac aac aac atg aaa cag ttc atc
cgc tac 2849Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile
Arg Tyr 750 755 760 ctc atc tcg tcc aac gtc ggg gaa gtt gtc tgt att
ttc ctg aca gca 2897Leu Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile
Phe Leu Thr Ala 765 770 775 gcc ctt gga ttt ccc gag gct ttg att cct
gtt cag ctg ctc tgg gtc 2945Ala Leu Gly Phe Pro Glu Ala Leu Ile Pro
Val Gln Leu Leu Trp Val 780 785 790 aat ctg gtg aca gat ggc ctg cct
gcc act gca ctg ggg ttc aac cct 2993Asn Leu Val Thr Asp Gly Leu Pro
Ala Thr Ala Leu Gly Phe Asn Pro 795 800 805 810 cct gat ctg gac atc
atg aat aaa cct ccc cgg aac cca aag gaa cca 3041Pro Asp Leu Asp Ile
Met Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro 815 820 825 ttg atc agc
ggg tgg ctc ttt ttc cgt tac ttg gct att ggc tgt tac 3089Leu Ile Ser
Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr 830 835 840 gtc
ggc gct gct acc gtg ggt gct gct gca tgg tgg ttc att gct gct 3137Val
Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala 845 850
855 gac ggt ggt cca aga gtg tcc ttc tac cag ctg agt cat ttc cta cag
3185Asp Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu Gln
860 865 870 tgt aaa gag gac aac ccg gac ttt gaa ggc gtg gat tgt gca
atc ttt 3233Cys Lys Glu Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala
Ile Phe 875 880 885 890 gaa tcc cca tac ccg atg aca atg gcg ctc tct
gtt cta gta act ata 3281Glu Ser Pro Tyr Pro Met Thr Met Ala Leu Ser
Val Leu Val Thr Ile 895 900 905 gaa atg tgt aac gcc ctc aac agc ttg
tcc gaa aac cag tcc ttg ctg 3329Glu Met Cys Asn Ala Leu Asn Ser Leu
Ser Glu Asn Gln Ser Leu Leu 910 915 920 agg atg ccc ccc tgg gag aac
atc tgg ctc gtg ggc tcc atc tgc ctg 3377Arg Met Pro Pro Trp Glu Asn
Ile Trp Leu Val Gly Ser Ile Cys Leu 925 930 935 tcc atg tca ctc cac
ttc ctg atc ctc tat gtc gaa ccc ttg cca ctc 3425Ser Met Ser Leu His
Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu 940 945 950 atc ttc cag
atc aca ccg ctg aac gtg acc cag tgg ctg atg gtg ctg 3473Ile Phe Gln
Ile Thr Pro Leu Asn Val Thr Gln Trp Leu Met Val Leu 955 960 965 970
aaa atc tcc ttg ccc gtg att ctc atg gat gag acg ctc aag ttt gtg
3521Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe Val
975 980 985 gcc cgc aac tac ctg gaa cct gca ata ctg gag taa
ccgcttccta 3567Ala Arg Asn Tyr Leu Glu Pro Ala Ile Leu Glu 990 995
aaccattttg cagaaatgta agggtgttcg gttgcgtgca tgtgcgtttt tagcaacaca
3627tctaccaacc ctgtgcatga ctgatgttgg ggaaaaagaa aagtaaaaaa
cttcccaact 3687cactttgtgt tatgtggagg aaatgtgtat taccaatggg
gttgttagct tttaaatcaa 3747aatactgatt acagatgtac aatttagctt
aatcagaaag cctctccaga gaagtttggt 3807ttctttgctg caagaggaat
gaggctctgt aaccttatct aagaacttgg aagccgtcag 3867ccaagtcgcc
acatttctct gcaaaatgtc atagcttata taaatgtaca gtattcaatt
3927gtaatgcatg ccttcggttg taagtagcca gatccctctc cagtgacatt
ggaacatgct 3987actttttaat tggccctgta cagtttgctt atttataaat
tcattaaaaa cactacaggt 4047gttgaatggt taaaatgtag gcctccagtt
cattttcagt tattttctga gtgtgcagac 4107agctatttcg cactgtatta
aatgtaactt atttaatgaa atcagaagca gtagacagat 4167gttggtgcaa
tacaaatatt gtgatgcatt tatcttaata aaatgctaaa tgtcaattta
4227tcactgcgca tgtttgactt tagactgtaa atagagatca gtttgtttct
ttctgtgctg 4287gtaacaatga gcgtcgcaca gacatggttt caggtaaata
aatctattct atgataaaaa 4347aaaaaaaaaa aa 43592997PRTHomo sapiens
2Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 1
5 10 15 Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys
Leu 20 25 30 Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu
Gly Lys Thr 35 40 45 Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp
Leu Leu Val Arg Ile 50 55 60 Leu Leu Leu Ala Ala Cys Ile Ser Phe
Val Leu Ala Trp Phe Glu Glu 65 70 75 80 Gly Glu Glu Thr Ile Thr Ala
Phe Val Glu Pro Phe Val Ile Leu Leu 85 90 95 Ile Leu Val Ala Asn
Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 100 105 110 Glu Asn Ala
Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 115 120 125 Val
Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 130 135
140 Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro
145 150 155 160 Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu
Arg Val Asp 165 170 175 Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val
Ile Lys His Thr Asp 180 185 190 Pro Val Pro Asp Pro Arg Ala Val Asn
Gln Asp Lys Lys Asn Met Leu 195 200 205 Phe Ser Gly Thr Asn Ile Ala
Ala Gly Lys Ala Met Gly Val Val Val 210 215 220 Ala Thr Gly Val Asn
Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 225 230 235 240 Ala Thr
Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 245 250 255
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 260
265 270 Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser
Trp 275 280 285 Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala
Leu Ala Val 290 295 300 Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile
Thr Thr Cys Leu Ala 305 310 315 320 Leu Gly Thr Arg Arg Met Ala Lys
Lys Asn Ala Ile Val Arg Ser Leu 325 330 335 Pro Ser Val Glu Thr Leu
Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 340 345 350 Thr Gly Thr Leu
Thr Thr Asn Gln
Met Ser Val Cys Arg Met Phe Ile 355 360 365 Leu Asp Arg Val Glu Gly
Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 370 375 380 Thr Gly Ser Thr
Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 385 390 395 400 Pro
Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 405 410
415 Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
420 425 430 Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr
Cys Leu 435 440 445 Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys
Gly Leu Ser Lys 450 455 460 Ile Glu Arg Ala Asn Ala Cys Asn Ser Val
Ile Lys Gln Leu Met Lys 465 470 475 480 Lys Glu Phe Thr Leu Glu Phe
Ser Arg Asp Arg Lys Ser Met Ser Val 485 490 495 Tyr Cys Thr Pro Asn
Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 500 505 510 Val Lys Gly
Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 515 520 525 Val
Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 530 535
540 Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys
545 550 555 560 Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu
Glu Met His 565 570 575 Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu
Thr Asn Leu Thr Phe 580 585 590 Val Gly Cys Val Gly Met Leu Asp Pro
Pro Arg Ile Glu Val Ala Ser 595 600 605 Ser Val Lys Leu Cys Arg Gln
Ala Gly Ile Arg Val Ile Met Ile Thr 610 615 620 Gly Asp Asn Lys Gly
Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 625 630 635 640 Phe Gly
Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 645 650 655
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 660
665 670 Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val
Glu 675 680 685 Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly
Asp Gly Val 690 695 700 Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile
Gly Ile Ala Met Gly 705 710 715 720 Ser Gly Thr Ala Val Ala Lys Thr
Ala Ser Glu Met Val Leu Ala Asp 725 730 735 Asp Asn Phe Ser Thr Ile
Val Ala Ala Val Glu Glu Gly Arg Ala Ile 740 745 750 Tyr Asn Asn Met
Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 755 760 765 Gly Glu
Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 770 775 780
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 785
790 795 800 Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp
Ile Met 805 810 815 Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile
Ser Gly Trp Leu 820 825 830 Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr
Val Gly Ala Ala Thr Val 835 840 845 Gly Ala Ala Ala Trp Trp Phe Ile
Ala Ala Asp Gly Gly Pro Arg Val 850 855 860 Ser Phe Tyr Gln Leu Ser
His Phe Leu Gln Cys Lys Glu Asp Asn Pro 865 870 875 880 Asp Phe Glu
Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 885 890 895 Thr
Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 900 905
910 Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu
915 920 925 Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu
His Phe 930 935 940 Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe
Gln Ile Thr Pro 945 950 955 960 Leu Asn Val Thr Gln Trp Leu Met Val
Leu Lys Ile Ser Leu Pro Val 965 970 975 Ile Leu Met Asp Glu Thr Leu
Lys Phe Val Ala Arg Asn Tyr Leu Glu 980 985 990 Pro Ala Ile Leu Glu
995 33795DNASus scrofamisc_featurePig SERCA2a polynucleotide
3ggcccccgca gcc atg gag aac gcg cac aca aag acg gtg gag gag gtg 49
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val 1 5 10 ctg ggc cac
ttc ggc gtc aac gag agc acg ggg ctg agc ctg gag cag 97Leu Gly His
Phe Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln 15 20 25 gtc
aag aag ctc aag gag aga tgg ggc tcc aac gag tta ccg gct gaa 145Val
Lys Lys Leu Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu 30 35
40 gaa ggg aaa acc ttg ctg gaa ctt gtg att gag cag ttt gaa gac tta
193Glu Gly Lys Thr Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu
45 50 55 60 ctc gtt aga att tta ttg ttg gca gca tgt ata tct ttt gtt
ttg gct 241Leu Val Arg Ile Leu Leu Leu Ala Ala Cys Ile Ser Phe Val
Leu Ala 65 70 75 tgg ttt gaa gaa ggc gaa gaa aca att aca gcc ttt
gta gaa ccc ttt 289Trp Phe Glu Glu Gly Glu Glu Thr Ile Thr Ala Phe
Val Glu Pro Phe 80 85 90 gta att tta ctt ata tta gta gcc aat gca
att gtg ggt gta tgg cag 337Val Ile Leu Leu Ile Leu Val Ala Asn Ala
Ile Val Gly Val Trp Gln 95 100 105 gaa agg aat gca gaa aat gcc atc
gaa gcc ctt aag gag tat gag cct 385Glu Arg Asn Ala Glu Asn Ala Ile
Glu Ala Leu Lys Glu Tyr Glu Pro 110 115 120 gaa atg ggc aaa gtg tat
cga cag gac agg aag agt gta caa cga att 433Glu Met Gly Lys Val Tyr
Arg Gln Asp Arg Lys Ser Val Gln Arg Ile 125 130 135 140 aaa gct aaa
gac ata gtt cct ggt gat att gta gaa att gct gtt ggt 481Lys Ala Lys
Asp Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly 145 150 155 gac
aaa gtt cct gct gat ata aga tta acg tcc atc aaa tct act act 529Asp
Lys Val Pro Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr 160 165
170 cta aga gtt gac cag tca att ctc aca ggt gag tct gtc tct gtc atc
577Leu Arg Val Asp Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile
175 180 185 aag cac acc gac cct gtc cct gac cca cgg gct gtc aac caa
gat aag 625Lys His Thr Asp Pro Val Pro Asp Pro Arg Ala Val Asn Gln
Asp Lys 190 195 200 aag aac atg ctc ttt tct ggt aca aac ata gca gct
ggc aaa gcc atg 673Lys Asn Met Leu Phe Ser Gly Thr Asn Ile Ala Ala
Gly Lys Ala Met 205 210 215 220 gga gtg gtg gtg gca act gga gtt aac
act gaa att ggc aag atc cgg 721Gly Val Val Val Ala Thr Gly Val Asn
Thr Glu Ile Gly Lys Ile Arg 225 230 235 gat gaa atg gta gca acg gaa
cag gag aga aca ccc ctc cag cag aaa 769Asp Glu Met Val Ala Thr Glu
Gln Glu Arg Thr Pro Leu Gln Gln Lys 240 245 250 cta gat gag ttt ggg
gaa cag ctt tcc aaa gtc atc tcc ctt att tgc 817Leu Asp Glu Phe Gly
Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys 255 260 265 att gca gtc
tgg atc ata aac att ggg cac ttc aat gac ccg gtt cat 865Ile Ala Val
Trp Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His 270 275 280 gga
ggc tcc tgg atc aga ggt gct att tat tac ttt aaa att gca gtg 913Gly
Gly Ser Trp Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val 285 290
295 300 gcc ctg gct gta gca gcc att cct gaa ggc ctg cct gct gtc att
acc 961Ala Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile
Thr 305 310 315 acc tgc ctg gct ctt gga act cgt aga atg gca aag aaa
aat gcc att 1009Thr Cys Leu Ala Leu Gly Thr Arg Arg Met Ala Lys Lys
Asn Ala Ile 320 325 330 gtt cga agt ctc cct tct gtg gaa acc ctt ggt
tgc act tcc gtt atc 1057Val Arg Ser Leu Pro Ser Val Glu Thr Leu Gly
Cys Thr Ser Val Ile 335 340 345 tgc tca gac aag act ggt aca ctt aca
aca aac cag atg tca gtc tgc 1105Cys Ser Asp Lys Thr Gly Thr Leu Thr
Thr Asn Gln Met Ser Val Cys 350 355 360 agg atg ttc att ctg gac aaa
gtt gaa ggt gat act tgt tcc ctg aat 1153Arg Met Phe Ile Leu Asp Lys
Val Glu Gly Asp Thr Cys Ser Leu Asn 365 370 375 380 gag ttt acc ata
act gga tca aca tat gct cct att gga gaa gtc cat 1201Glu Phe Thr Ile
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His 385 390 395 aaa gat
gat aaa cca gta aag tgt cat caa tat gat ggt ctt gtg gaa 1249Lys Asp
Asp Lys Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu 400 405 410
ttg gca aca att tgt gct ctc tgt aat gac tct gct ttg gat tac aat
1297Leu Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn
415 420 425 gag gca aag ggt gtg tat gaa aaa gtt gga gaa gct aca gag
act gct 1345Glu Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Thr Glu
Thr Ala 430 435 440 ctc act tgc ctg gta gag aag atg aat gtc ttt gat
act gag tta aag 1393Leu Thr Cys Leu Val Glu Lys Met Asn Val Phe Asp
Thr Glu Leu Lys 445 450 455 460 ggt ctt tct aaa ata gaa cga gca aat
gcc tgc aac tcg gtc att aaa 1441Gly Leu Ser Lys Ile Glu Arg Ala Asn
Ala Cys Asn Ser Val Ile Lys 465 470 475 caa ttg atg aaa aag gaa ttt
act cta gag ttt tca cgt gat aga aaa 1489Gln Leu Met Lys Lys Glu Phe
Thr Leu Glu Phe Ser Arg Asp Arg Lys 480 485 490 tca atg tca gtt tat
tgt aca cca aac aaa cca agc cgg aca tcg atg 1537Ser Met Ser Val Tyr
Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met 495 500 505 agc aaa atg
ttt gtg aag ggt gct ccc gaa ggt gtc att gac agg tgt 1585Ser Lys Met
Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys 510 515 520 acc
cac att cga gtt gga agt act aaa gtc ccc atg act cct ggc gtc 1633Thr
His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val 525 530
535 540 aaa cag aag atc atg tct gtc att cgg gaa tgg ggc agt ggc agc
gac 1681Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser
Asp 545 550 555 aca ctg cga tgc ctg gct ctg gcc act cat gac aac ccg
atg aga aga 1729Thr Leu Arg Cys Leu Ala Leu Ala Thr His Asp Asn Pro
Met Arg Arg 560 565 570 gaa gaa atg aac ctt gag gat tct gcc aac ttt
att aaa tac gag acc 1777Glu Glu Met Asn Leu Glu Asp Ser Ala Asn Phe
Ile Lys Tyr Glu Thr 575 580 585 aat ctg act ttc gtt ggc tgt gtg ggc
atg ctg gac cct cca aga atc 1825Asn Leu Thr Phe Val Gly Cys Val Gly
Met Leu Asp Pro Pro Arg Ile 590 595 600 gaa gtg gcc tcc tct gtg aag
ctg tgc cgg cag gca ggc atc cgg gtc 1873Glu Val Ala Ser Ser Val Lys
Leu Cys Arg Gln Ala Gly Ile Arg Val 605 610 615 620 att atg atc aca
ggc gac aac aag ggt acc gct gtg gcc atc tgc cgt 1921Ile Met Ile Thr
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg 625 630 635 cgc att
ggc atc ttt ggg cag gac gag gat gtg acg tca aag gct ttt 1969Arg Ile
Gly Ile Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe 640 645 650
aca ggt cgg gag ttt gat gag ctc aat cct tca gcc cag aga gaa gcc
2017Thr Gly Arg Glu Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Glu Ala
655 660 665 tgc ctg aat gcc cgc tgt ttc gct cga gtt gaa cct tcc cac
aag tct 2065Cys Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser His
Lys Ser 670 675 680 aaa att gta gaa ttt ctt cag tct ttt gat gag att
aca gct atg act 2113Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile
Thr Ala Met Thr 685 690 695 700 ggg gac ggt gtg aat gat gct cct gct
ctg aag aag tct gag atc ggc 2161Gly Asp Gly Val Asn Asp Ala Pro Ala
Leu Lys Lys Ser Glu Ile Gly 705 710 715 att gcc atg ggc tct ggc acc
gcg gtg gct aaa act gcc tcc gag atg 2209Ile Ala Met Gly Ser Gly Thr
Ala Val Ala Lys Thr Ala Ser Glu Met 720 725 730 gtc ctg gct gat gac
aac ttc tcc acc att gtg gct gct gtg gag gag 2257Val Leu Ala Asp Asp
Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu 735 740 745 gga cgg gca
ata tac aac aac atg aag cag ttc att cgc tac ctc atc 2305Gly Arg Ala
Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile 750 755 760 tcg
tcc aac gtg gga gaa gtt gtc tgt att ttc ctg aca gca gcc ctt 2353Ser
Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu 765 770
775 780 gga ttt cct gag gct tta att cct gtc cag ctg ctc tgg gtc aat
ctg 2401Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn
Leu 785 790 795 gtg aca gat ggc ctg cct gcc act gca ctg ggg ttc aat
cct cct gat 2449Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn
Pro Pro Asp 800 805 810 ctg gac att atg aac aaa cca ccc cgg aac cca
aag gaa cca ctg atc 2497Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro
Lys Glu Pro Leu Ile 815 820 825 agt ggg tgg ctc ttt ttc cgc tac ctg
gct att ggc tgt tac gtt ggt 2545Ser Gly Trp Leu Phe Phe Arg Tyr Leu
Ala Ile Gly Cys Tyr Val Gly 830 835 840 gct gct act gtg ggt gct gct
gcg tgg tgg ttc att gct gcc gat ggt 2593Ala Ala Thr Val Gly Ala Ala
Ala Trp Trp Phe Ile Ala Ala Asp Gly 845 850 855 860 ggt ccg aga gtg
acc ttc tac cag ctg agt cat ttc cta cag tgt aaa 2641Gly Pro Arg Val
Thr Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys 865 870 875 gag gac
aac cca gac ttt gag gga gtg gat tgt gca gtc ttt gaa tcc 2689Glu Asp
Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Val Phe Glu Ser 880 885 890
cct tac cca atg aca atg gcg ctg tct gtt cta gtc acc ata gag atg
2737Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met
895 900 905 tgt aac gcc ctc aac agt ttg tcg gaa aac cag tcc ctg cta
agg atg 2785Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu
Arg Met 910 915 920 cca cct tgg gag aac att tgg ctc gtg ggc tcc atc
tgc ctg tcc atg 2833Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile
Cys Leu Ser Met 925 930 935 940 tca ctc cac ttc cta atc ctc tat gtg
gaa ccc ctg cca ctt atc ttc 2881Ser Leu His Phe Leu Ile Leu Tyr Val
Glu Pro Leu Pro Leu Ile Phe 945 950 955 cag atc aca ccg ctg aat ttg
acc cag tgg ctg atg gtg ctg aaa atc
2929Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile
960 965 970 tcc ttg cct gtg att cta atg gat gag acc ctc aag ttt gtg
gcc cgc 2977Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe Val
Ala Arg 975 980 985 aac tac ctg gaa cct gca ata ctg gag taa
ccgcttccta aaccattttg 3027Asn Tyr Leu Glu Pro Ala Ile Leu Glu 990
995 cagaaatgta agggtgttcg gttgcgtgca tgtgcgtttt tagcaacaca
tctaccagcc 3087ctctgcatga ttgatgttgg gggtaaaaga aaattagaaa
aaagtcccca attcattgtg 3147tgttacgtgg aggaaacatg tattaccagt
ggggtttttt agcttttaaa tcaaaatgat 3207aattacaaat gtacaatttt
agcttaatgg atcagaaatc ctctccagag aagtttggtt 3267tctttgctgc
aagaagaatg aggttctgaa accttaccca agaacttaga agccatcagc
3327caagtatcca tgtttctctg tgcaaaatgt catagcttaa ataaatgtac
aatattcaat 3387tgtaatgcat gccttcaagt tgtaagtagc cagatttctc
tatgatgtca ttgaaacatg 3447ctacttttta attggccctg tacagtttgc
ttatttataa atttattgaa aacactacag 3507gtgttggtta aaatgtaggc
ttctagctca taacttcagt tattttttga gtgtgcaaac 3567agctattttg
cactgtatta aatgtaactt atttaatgaa atcaaaagca gtagacagat
3627gttggtgcaa tacgaatatt gtgatgcatt tatattaata aaatgctaaa
cgtcaattta 3687tcacaacgca tgtttgactt tagactgtaa atagagatca
gtttatttct gtgctggtaa 3747aaagtattgc acagacatgg tttcaggtaa
ataaatctat tctatgat 37954997PRTSus scrofa 4Met Glu Asn Ala His Thr
Lys Thr Val Glu Glu Val Leu Gly His Phe 1 5 10 15 Gly Val Asn Glu
Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 20 25 30 Lys Glu
Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 35 40 45
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 50
55 60 Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu
Glu 65 70 75 80 Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val
Ile Leu Leu 85 90 95 Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp
Gln Glu Arg Asn Ala 100 105 110 Glu Asn Ala Ile Glu Ala Leu Lys Glu
Tyr Glu Pro Glu Met Gly Lys 115 120 125 Val Tyr Arg Gln Asp Arg Lys
Ser Val Gln Arg Ile Lys Ala Lys Asp 130 135 140 Ile Val Pro Gly Asp
Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 145 150 155 160 Ala Asp
Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 165 170 175
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 180
185 190 Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met
Leu 195 200 205 Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly
Val Val Val 210 215 220 Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile
Arg Asp Glu Met Val 225 230 235 240 Ala Thr Glu Gln Glu Arg Thr Pro
Leu Gln Gln Lys Leu Asp Glu Phe 245 250 255 Gly Glu Gln Leu Ser Lys
Val Ile Ser Leu Ile Cys Ile Ala Val Trp 260 265 270 Ile Ile Asn Ile
Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 275 280 285 Ile Arg
Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 290 295 300
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 305
310 315 320 Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg
Ser Leu 325 330 335 Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile
Cys Ser Asp Lys 340 345 350 Thr Gly Thr Leu Thr Thr Asn Gln Met Ser
Val Cys Arg Met Phe Ile 355 360 365 Leu Asp Lys Val Glu Gly Asp Thr
Cys Ser Leu Asn Glu Phe Thr Ile 370 375 380 Thr Gly Ser Thr Tyr Ala
Pro Ile Gly Glu Val His Lys Asp Asp Lys 385 390 395 400 Pro Val Lys
Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 405 410 415 Cys
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 420 425
430 Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
435 440 445 Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu
Ser Lys 450 455 460 Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys
Gln Leu Met Lys 465 470 475 480 Lys Glu Phe Thr Leu Glu Phe Ser Arg
Asp Arg Lys Ser Met Ser Val 485 490 495 Tyr Cys Thr Pro Asn Lys Pro
Ser Arg Thr Ser Met Ser Lys Met Phe 500 505 510 Val Lys Gly Ala Pro
Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 515 520 525 Val Gly Ser
Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 530 535 540 Met
Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 545 550
555 560 Leu Ala Leu Ala Thr His Asp Asn Pro Met Arg Arg Glu Glu Met
Asn 565 570 575 Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn
Leu Thr Phe 580 585 590 Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg
Ile Glu Val Ala Ser 595 600 605 Ser Val Lys Leu Cys Arg Gln Ala Gly
Ile Arg Val Ile Met Ile Thr 610 615 620 Gly Asp Asn Lys Gly Thr Ala
Val Ala Ile Cys Arg Arg Ile Gly Ile 625 630 635 640 Phe Gly Gln Asp
Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 645 650 655 Phe Asp
Glu Leu Asn Pro Ser Ala Gln Arg Glu Ala Cys Leu Asn Ala 660 665 670
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 675
680 685 Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly
Val 690 695 700 Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile
Ala Met Gly 705 710 715 720 Ser Gly Thr Ala Val Ala Lys Thr Ala Ser
Glu Met Val Leu Ala Asp 725 730 735 Asp Asn Phe Ser Thr Ile Val Ala
Ala Val Glu Glu Gly Arg Ala Ile 740 745 750 Tyr Asn Asn Met Lys Gln
Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 755 760 765 Gly Glu Val Val
Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 770 775 780 Ala Leu
Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 785 790 795
800 Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met
805 810 815 Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly
Trp Leu 820 825 830 Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly
Ala Ala Thr Val 835 840 845 Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala
Asp Gly Gly Pro Arg Val 850 855 860 Thr Phe Tyr Gln Leu Ser His Phe
Leu Gln Cys Lys Glu Asp Asn Pro 865 870 875 880 Asp Phe Glu Gly Val
Asp Cys Ala Val Phe Glu Ser Pro Tyr Pro Met 885 890 895 Thr Met Ala
Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 900 905 910 Asn
Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 915 920
925 Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe
930 935 940 Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile
Thr Pro 945 950 955 960 Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys
Ile Ser Leu Pro Val 965 970 975 Ile Leu Met Asp Glu Thr Leu Lys Phe
Val Ala Arg Asn Tyr Leu Glu 980 985 990 Pro Ala Ile Leu Glu 995
54303DNARattus norvegicusmisc_featureRat SERCA2a polynucleotide
5cggagccgtc cccgacgcca cctcccgtct cctccgccgc agtttcctcc gccgctgtcg
60ggggtgcaga gctgaggggc tcgggcaggc gcgccgcgca gctcctctcc agtcgcccgc
120ctcgccgtcc tccccaccga gggctcgccc gggcgcccct cctcagccgc
gccgggtctc 180ctcagcgcag cgccgcggcc tgcgctacct gcggccggct
ggcaacagag gcaacgcaca 240ctcgcggcgg ggcgggaggc tcgcagcccc
tcgggcgggc tcggcgaggc ccggccgcgt 300gcggcggttt ctgggggagg
gggctcgggt gattcagcgc ccggtcaggc ggaagcggcc 360gccgccgcgg
aggaggagga gaaagaggag gggacagctg tccgcgcccg ggcgcccgcg
420gtggcacgag cccgcggccc gagtgcgagg cggaggcgag gaggccgcgg
ggacgcgagg 480cgaggccggc cggggccccc gcagcc atg gag aac gct cac aca
aag acc gtg 533 Met Glu Asn Ala His Thr Lys Thr Val 1 5 gag gag gtg
ctg ggc cac ttc ggc gtc aac gag agc acg ggg ctg agc 581Glu Glu Val
Leu Gly His Phe Gly Val Asn Glu Ser Thr Gly Leu Ser 10 15 20 25 ctg
gag cag gtc aag aag ctc aag gag aga tgg ggc tcc aac gaa ttg 629Leu
Glu Gln Val Lys Lys Leu Lys Glu Arg Trp Gly Ser Asn Glu Leu 30 35
40 ccg gct gaa gaa gga aag acc ttg ctg gaa ctt gtg atc gag cag ttt
677Pro Ala Glu Glu Gly Lys Thr Leu Leu Glu Leu Val Ile Glu Gln Phe
45 50 55 gaa gac tta cta gtt aga att tta ttg ctg gca gca tgt ata
tct ttc 725Glu Asp Leu Leu Val Arg Ile Leu Leu Leu Ala Ala Cys Ile
Ser Phe 60 65 70 gtt ttg gct tgg ttc gaa gaa ggt gaa gaa acg att
aca gcc ttt gta 773Val Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr Ile
Thr Ala Phe Val 75 80 85 gaa cct ttt gta att ctg ctt ata ttg gta
gcc aat gca att gtg ggt 821Glu Pro Phe Val Ile Leu Leu Ile Leu Val
Ala Asn Ala Ile Val Gly 90 95 100 105 gta tgg cag gag aga aac gct
gaa aat gca ata gaa gct ctt aag gag 869Val Trp Gln Glu Arg Asn Ala
Glu Asn Ala Ile Glu Ala Leu Lys Glu 110 115 120 tat gaa cct gaa atg
ggc aag gtg tat cga cag gac aga aag agt gtg 917Tyr Glu Pro Glu Met
Gly Lys Val Tyr Arg Gln Asp Arg Lys Ser Val 125 130 135 cag cgg att
aaa gcg aaa gat ata gtt cct ggg gat ata gtg gaa att 965Gln Arg Ile
Lys Ala Lys Asp Ile Val Pro Gly Asp Ile Val Glu Ile 140 145 150 gct
gtt ggt gac aaa gtt ccg gct gac att aga ttg aca tcc atc aag 1013Ala
Val Gly Asp Lys Val Pro Ala Asp Ile Arg Leu Thr Ser Ile Lys 155 160
165 tct aca act ctg aga gtt gac cag tcg att ctt aca ggt gaa tct gtc
1061Ser Thr Thr Leu Arg Val Asp Gln Ser Ile Leu Thr Gly Glu Ser Val
170 175 180 185 tcg gtc atc aag cat act gac cct gtc cct gac cca cga
gct gtt aat 1109Ser Val Ile Lys His Thr Asp Pro Val Pro Asp Pro Arg
Ala Val Asn 190 195 200 caa gac aaa aag aac atg ctc ttt tct ggc aca
aac atc gct gct ggc 1157Gln Asp Lys Lys Asn Met Leu Phe Ser Gly Thr
Asn Ile Ala Ala Gly 205 210 215 aaa gct atg gga gtg gtg gtg gcg act
gga gtc aat act gag atc ggc 1205Lys Ala Met Gly Val Val Val Ala Thr
Gly Val Asn Thr Glu Ile Gly 220 225 230 aag atc cgg gat gaa atg gtt
gca aca gaa cag gag aga aca ccc cta 1253Lys Ile Arg Asp Glu Met Val
Ala Thr Glu Gln Glu Arg Thr Pro Leu 235 240 245 cag cag aag ctg gac
gag ttt ggg gaa cag ctt tcc aaa gtt atc tcc 1301Gln Gln Lys Leu Asp
Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser 250 255 260 265 ctc att
tgc att gca gtc tgg atc atc aac atc ggg cat ttc aat gac 1349Leu Ile
Cys Ile Ala Val Trp Ile Ile Asn Ile Gly His Phe Asn Asp 270 275 280
cca gtt cat ggt ggc tct tgg atc aga ggt gcc atc tac tac ttt aag
1397Pro Val His Gly Gly Ser Trp Ile Arg Gly Ala Ile Tyr Tyr Phe Lys
285 290 295 att gca gtg gcc ctg gct gtt gct gcc atc cct gag ggt ctg
cct gct 1445Ile Ala Val Ala Leu Ala Val Ala Ala Ile Pro Glu Gly Leu
Pro Ala 300 305 310 gtc atc acc acc tgc ttg gct ctt gga act cga agg
atg gca aag aaa 1493Val Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg
Met Ala Lys Lys 315 320 325 aat gct att gtt cga agt ctg cct tct gtg
gaa acc ctt ggt tgt act 1541Asn Ala Ile Val Arg Ser Leu Pro Ser Val
Glu Thr Leu Gly Cys Thr 330 335 340 345 tct gtt atc tgc tca gac aag
acc ggc aca ctt acc aca aac cag atg 1589Ser Val Ile Cys Ser Asp Lys
Thr Gly Thr Leu Thr Thr Asn Gln Met 350 355 360 tcc gtc tgc agg atg
ttc att ctg gac aaa gta gaa ggt gat act tgt 1637Ser Val Cys Arg Met
Phe Ile Leu Asp Lys Val Glu Gly Asp Thr Cys 365 370 375 tcc ctt aat
gag ttt acc ata act gga tca acc tat gca ccc att gga 1685Ser Leu Asn
Glu Phe Thr Ile Thr Gly Ser Thr Tyr Ala Pro Ile Gly 380 385 390 gaa
gtg caa aaa gat gac aag cca gtg aaa tgc cat cag tat gac ggg 1733Glu
Val Gln Lys Asp Asp Lys Pro Val Lys Cys His Gln Tyr Asp Gly 395 400
405 ctt gta gag tta gca acg atc tgt gct ctg tgt aat gac tct gct ttg
1781Leu Val Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu
410 415 420 425 gat tac aat gag gcg aag ggt gtg tat gaa aaa gtt gga
gaa gcc aca 1829Asp Tyr Asn Glu Ala Lys Gly Val Tyr Glu Lys Val Gly
Glu Ala Thr 430 435 440 gag act gct ctc acg tgc ctg gta gag aag atg
aat gta ttc gac acg 1877Glu Thr Ala Leu Thr Cys Leu Val Glu Lys Met
Asn Val Phe Asp Thr 445 450 455 gag ctg aag gga ctt tct aaa ata gaa
cgc gcc aac gcc tgc aac tcg 1925Glu Leu Lys Gly Leu Ser Lys Ile Glu
Arg Ala Asn Ala Cys Asn Ser 460 465 470 gtc ata aaa cag ctc atg aag
aag gaa ttc acg cta gag ttt tca cgt 1973Val Ile Lys Gln Leu Met Lys
Lys Glu Phe Thr Leu Glu Phe Ser Arg 475 480 485 gat aga aaa tca atg
tcc gtc tac tgt aca cca aac aaa ccg agc cgg 2021Asp Arg Lys Ser Met
Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg 490 495 500 505 acg tcc
atg agc aag atg ttt gtg aag ggt gct cca gaa ggt gtc atc 2069Thr Ser
Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile 510 515 520
gac agg tgc acc cac atc cga gtt gga agt acc aag gtc ccc atg acg
2117Asp Arg Cys Thr His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr
525 530 535 cct ggt gtt aaa cag aag att atg tct gtc att cgg gag tgg
ggc agt 2165Pro Gly Val Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp
Gly Ser 540 545 550 ggc agc gac aca ctg cgg tgc ctg gct ctg gcc act
cat gac aac ccg 2213Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr
His Asp Asn Pro 555 560 565 ctg agg aga gag gag atg cac ctg gaa gat
tct gcg aac ttc atc aaa 2261Leu Arg Arg Glu Glu Met His Leu Glu Asp
Ser Ala Asn Phe Ile Lys 570 575 580 585 tat gag acc aat ctg act ttc
gtt ggc tgt gtg ggc atg ctg gac cct 2309Tyr Glu Thr Asn Leu Thr Phe
Val Gly Cys Val Gly Met Leu Asp Pro
590 595 600 ccc agg att gaa gtg gcc tct tct gtg aag ctg tgc cgg caa
gcg ggc 2357Pro Arg Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln
Ala Gly 605 610 615 atc cga gtc atc atg atc act ggg gat aac aaa ggc
act gct gtg gcc 2405Ile Arg Val Ile Met Ile Thr Gly Asp Asn Lys Gly
Thr Ala Val Ala 620 625 630 atc tgt cgc cgc att ggc atc ttt ggg cag
gat gag gat gtg aca tca 2453Ile Cys Arg Arg Ile Gly Ile Phe Gly Gln
Asp Glu Asp Val Thr Ser 635 640 645 aag gct ttt aca ggg cga gaa ttt
gat gaa tta agc ccc tca gcc cag 2501Lys Ala Phe Thr Gly Arg Glu Phe
Asp Glu Leu Ser Pro Ser Ala Gln 650 655 660 665 aga gac gcc tgc tta
aat gcc cgt tgt ttt gct cga gtt gaa cct tcc 2549Arg Asp Ala Cys Leu
Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser 670 675 680 cac aag tct
aag atc gtt gag ttc ctg cag tcc ttt gat gag atc aca 2597His Lys Ser
Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr 685 690 695 gct
atg act ggt gat ggt gtg aac gac gcg ccc gct ctg aag aag tcg 2645Ala
Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ser 700 705
710 gaa atc ggg att gcc atg ggc tca ggg act gca gtg gct aag acg gcc
2693Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala
715 720 725 tct gag atg gtg ctg gcc gac gac aac ttc tcc acc atc gtg
gcc gct 2741Ser Glu Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val
Ala Ala 730 735 740 745 gtt gag gag ggg cgc gcc atc tac aac aac atg
aag cag ttc atc cgc 2789Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met
Lys Gln Phe Ile Arg 750 755 760 tac ctc atc tcc tcc aac gtg ggg gag
gtg gtc tgt atc ttc ctg acg 2837Tyr Leu Ile Ser Ser Asn Val Gly Glu
Val Val Cys Ile Phe Leu Thr 765 770 775 gca gcc ctt ggg ttt cct gaa
gct ttg att cct gtc cag tta ctc tgg 2885Ala Ala Leu Gly Phe Pro Glu
Ala Leu Ile Pro Val Gln Leu Leu Trp 780 785 790 gtc aat ctg gtg acg
gat ggt ctg cct gcc act gcg ctg ggg ttc aat 2933Val Asn Leu Val Thr
Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn 795 800 805 cct cca gat
ctg gac atc atg aac aaa ccc cca cgg aac cca aaa gaa 2981Pro Pro Asp
Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu 810 815 820 825
ccg ctg atc agc ggg tgg ctc ttt ttc cgt tac ctg gct att ggc tgt
3029Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys
830 835 840 tat gtt ggc gct gcc acc gtg ggt gct gct gcg tgg tgg ttc
atc gct 3077Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe
Ile Ala 845 850 855 gct gac ggt ggt ccg aga gtc tcc ttc tac cag ctg
agt cat ttc ctg 3125Ala Asp Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu
Ser His Phe Leu 860 865 870 cag tgt aag gag gac aac cca gac ttc gaa
gga gtg gat tgt gca atc 3173Gln Cys Lys Glu Asp Asn Pro Asp Phe Glu
Gly Val Asp Cys Ala Ile 875 880 885 ttt gag tcc ccg tat ccg atg aca
atg gca ctt tct gtt cta gtc acc 3221Phe Glu Ser Pro Tyr Pro Met Thr
Met Ala Leu Ser Val Leu Val Thr 890 895 900 905 ata gag atg tgc aat
gcc ctc aac agc ttg tct gaa aac cag tcc ctg 3269Ile Glu Met Cys Asn
Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu 910 915 920 ctg agg atg
ccc ccc tgg gag aac atc tgg ctc gtg ggc tcc atc tgc 3317Leu Arg Met
Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys 925 930 935 ttg
tcc atg tcc ctt cac ttc ttg atc ctc tac gtg gaa cct ttg cca 3365Leu
Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro 940 945
950 ctc att ttc cag atc aca ccg ctg aat ctg acc cag tgg ctg atg gtg
3413Leu Ile Phe Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val
955 960 965 ctg aaa atc tcc ctg cct gtg atc ctc atg gac gag acg ctc
aag ttt 3461Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu
Lys Phe 970 975 980 985 gtg gcc cga aac tac ctg gag cct gca ata ctg
gag taa ccgcttccta 3510Val Ala Arg Asn Tyr Leu Glu Pro Ala Ile Leu
Glu 990 995 aacattgcag aaatgtaagg gtgttcgggt gcgtgcatgt gcgttgttag
caacacatct 3570tccagccctc tgcatgactg agcttgggga aagagaaata
gaacagcccc cagctcactg 3630tgtgatgtgg aggaaatgtg tattacaagt
ggggttttag ctgttgagtc aaaataataa 3690caagtgtaca atttagcata
aggaatcgga gagcctctcc agagaagtcg gtttctttgc 3750tgcaagaaga
atgaggttct gaacccttat ccaagaacag aagccatcag ccaagtctcc
3810acatttctct gcaaaatgtt gtagcctcta taactgtatg atagtgtaat
gcatgccttc 3870agttgtaagt ggccagatcg cgctacagtg acattgaaac
ctgctctcta attggccctg 3930tacagtttgc ttatttataa attcatttaa
aacactacag ctgttgaatg gttacaacct 3990aggcctccgg tcctaacttc
agttgttctc ctcggtgtgc agccagctgt tccacactgt 4050attattgtaa
cttatttagt gaagtcagaa gcagtagaca gatgttggtg caatacaagt
4110attgtgtgca tttatcgtaa taaagtgctc cgcgtcggtt cagttcctca
cagcttctca 4170cagtgcatgt ctgactgtag tctgtaaata gaggtcagtg
tccgtgctgc taacaggtat 4230cgatcgcaca gacatgattt caggtaaata
aatcgattct acgataaacc ctcaaaaaaa 4290aaaaaaaaaa aaa
43036997PRTRattus norvegicus 6Met Glu Asn Ala His Thr Lys Thr Val
Glu Glu Val Leu Gly His Phe 1 5 10 15 Gly Val Asn Glu Ser Thr Gly
Leu Ser Leu Glu Gln Val Lys Lys Leu 20 25 30 Lys Glu Arg Trp Gly
Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 35 40 45 Leu Leu Glu
Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 50 55 60 Leu
Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 65 70
75 80 Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu
Leu 85 90 95 Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu
Arg Asn Ala 100 105 110 Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu
Pro Glu Met Gly Lys 115 120 125 Val Tyr Arg Gln Asp Arg Lys Ser Val
Gln Arg Ile Lys Ala Lys Asp 130 135 140 Ile Val Pro Gly Asp Ile Val
Glu Ile Ala Val Gly Asp Lys Val Pro 145 150 155 160 Ala Asp Ile Arg
Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 165 170 175 Gln Ser
Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 180 185 190
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 195
200 205 Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val
Val 210 215 220 Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp
Glu Met Val 225 230 235 240 Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln
Gln Lys Leu Asp Glu Phe 245 250 255 Gly Glu Gln Leu Ser Lys Val Ile
Ser Leu Ile Cys Ile Ala Val Trp 260 265 270 Ile Ile Asn Ile Gly His
Phe Asn Asp Pro Val His Gly Gly Ser Trp 275 280 285 Ile Arg Gly Ala
Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 290 295 300 Ala Ala
Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 305 310 315
320 Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
325 330 335 Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser
Asp Lys 340 345 350 Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys
Arg Met Phe Ile 355 360 365 Leu Asp Lys Val Glu Gly Asp Thr Cys Ser
Leu Asn Glu Phe Thr Ile 370 375 380 Thr Gly Ser Thr Tyr Ala Pro Ile
Gly Glu Val Gln Lys Asp Asp Lys 385 390 395 400 Pro Val Lys Cys His
Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 405 410 415 Cys Ala Leu
Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 420 425 430 Val
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 435 440
445 Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys
450 455 460 Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu
Met Lys 465 470 475 480 Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg
Lys Ser Met Ser Val 485 490 495 Tyr Cys Thr Pro Asn Lys Pro Ser Arg
Thr Ser Met Ser Lys Met Phe 500 505 510 Val Lys Gly Ala Pro Glu Gly
Val Ile Asp Arg Cys Thr His Ile Arg 515 520 525 Val Gly Ser Thr Lys
Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 530 535 540 Met Ser Val
Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 545 550 555 560
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 565
570 575 Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr
Phe 580 585 590 Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu
Val Ala Ser 595 600 605 Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg
Val Ile Met Ile Thr 610 615 620 Gly Asp Asn Lys Gly Thr Ala Val Ala
Ile Cys Arg Arg Ile Gly Ile 625 630 635 640 Phe Gly Gln Asp Glu Asp
Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 645 650 655 Phe Asp Glu Leu
Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 660 665 670 Arg Cys
Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 675 680 685
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 690
695 700 Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met
Gly 705 710 715 720 Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met
Val Leu Ala Asp 725 730 735 Asp Asn Phe Ser Thr Ile Val Ala Ala Val
Glu Glu Gly Arg Ala Ile 740 745 750 Tyr Asn Asn Met Lys Gln Phe Ile
Arg Tyr Leu Ile Ser Ser Asn Val 755 760 765 Gly Glu Val Val Cys Ile
Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 770 775 780 Ala Leu Ile Pro
Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 785 790 795 800 Leu
Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 805 810
815 Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu
820 825 830 Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala
Thr Val 835 840 845 Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly
Gly Pro Arg Val 850 855 860 Ser Phe Tyr Gln Leu Ser His Phe Leu Gln
Cys Lys Glu Asp Asn Pro 865 870 875 880 Asp Phe Glu Gly Val Asp Cys
Ala Ile Phe Glu Ser Pro Tyr Pro Met 885 890 895 Thr Met Ala Leu Ser
Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 900 905 910 Asn Ser Leu
Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 915 920 925 Asn
Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 930 935
940 Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro
945 950 955 960 Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser
Leu Pro Val 965 970 975 Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala
Arg Asn Tyr Leu Glu 980 985 990 Pro Ala Ile Leu Glu 995 74353DNAMus
musculusmisc_featureMouse SERCA2a polynucleotide 7agagcagcct
ccgcggagcc gtccccgacg ccgccacctc ccgtctcctc cgccgcagtt 60ccctccgccg
ccgctgtcgg gggtgcagag ctgaggggct cgggccggcg cgccgcgcag
120ctcctctccc gtcgcctgcc tcgcggttcc cggcgccgag ggctcggccc
ggcgccgctc 180ctcatctgcg ccccgtctcc tcggcgcagc gcccggggcc
tgcgctgccc gcggccggct 240ggcagctgct gaagcgaccc acactcgcgg
cggggcggga ggctcgcagt ccctcgggcg 300ggctcggcga ggccgggccg
cgtgcggcgg tttctggggg agggggctcg ggtgattcag 360cgccccggtc
aggcggaagc ggccgccgcc gccgcggagg aggaggagga gaagaaaaag
420gaggggacag ctgtccgcgc ccgggcgccc gcggtggcac gagcccgcgg
ccggagtgcg 480aggcggtagg cgaggaggcc gcggggacgc gaggcgaggc
cggccggggc ccccgcagcc 540atg gag aac gct cac aca aag acc gtg gag
gag gtg ctg ggc cac ttc 588Met Glu Asn Ala His Thr Lys Thr Val Glu
Glu Val Leu Gly His Phe 1 5 10 15 ggg gtc aac gag agc acg ggg ctg
agc ttg gag cag gtc aag aag ctc 636Gly Val Asn Glu Ser Thr Gly Leu
Ser Leu Glu Gln Val Lys Lys Leu 20 25 30 aag gag aga tgg ggc tcc
aac gaa ttg ccg gct gaa gaa gga aaa acc 684Lys Glu Arg Trp Gly Ser
Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 35 40 45 ttg ctg gaa ctt
gtg att gag cag ttt gaa gac tta cta gtt aga att 732Leu Leu Glu Leu
Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 50 55 60 tta ctg
ctg gca gca tgt ata tct ttc gtt ttg gct tgg ttc gag gaa 780Leu Leu
Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 65 70 75 80
ggg gaa gaa acg att aca gcc ttt gta gag ccg ttt gta att ctg ctt
828Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
85 90 95 atc ttg gta gcc aat gca atc gtg ggt gtg tgg cag gaa aga
aat gct 876Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg
Asn Ala 100 105 110 gaa aat gca ata gaa gct ctt aag gaa tat gag cct
gaa atg ggc aaa 924Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro
Glu Met Gly Lys 115 120 125 gtg tat cga cag gac aga aag agt gtg caa
cga att aaa gct aaa gac 972Val Tyr Arg Gln Asp Arg Lys Ser Val Gln
Arg Ile Lys Ala Lys Asp 130 135 140 ata gtt cct ggt gat ata gtg gaa
att gct gtt ggt gac aaa gtt cct 1020Ile Val Pro Gly Asp Ile Val Glu
Ile Ala Val Gly Asp Lys Val Pro 145 150 155 160 gct gat att aga ttg
aca tcc atc aag tct aca act cta aga gtc gac 1068Ala Asp Ile Arg Leu
Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 165 170 175 cag tca att
ctt aca ggt gaa tct gtc tcc gtc atc aag cat act gac 1116Gln Ser Ile
Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 180 185 190 cct
gtc cct gac ccc cga gct gtt aat caa gac aaa aag aac atg ctc 1164Pro
Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 195 200
205 ttt tct ggt aca aac att gct gct ggg aaa gct atg gga gtg gtg gtg
1212Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val
210 215 220 gca act gga gtt aat act gag atc ggc aag atc cgg gat gaa
atg gtg
1260Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val
225 230 235 240 gca aca gaa cag gag aga aca ccc cta cag cag aag cta
gac gag ttt 1308Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu
Asp Glu Phe 245 250 255 ggg gag cag ctt tcc aaa gtt atc tcc ctc att
tgc att gca gtc tgg 1356Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile
Cys Ile Ala Val Trp 260 265 270 atc atc aac att ggg cat ttc aat gac
cca gtt cat ggt ggc tcc tgg 1404Ile Ile Asn Ile Gly His Phe Asn Asp
Pro Val His Gly Gly Ser Trp 275 280 285 atc agg ggt gcc atc tac tac
ttt aag att gcc gtg gcc ctg gct gtt 1452Ile Arg Gly Ala Ile Tyr Tyr
Phe Lys Ile Ala Val Ala Leu Ala Val 290 295 300 gcc gca atc cct gag
ggt ctg cct gct gtc atc acc acc tgc tta gct 1500Ala Ala Ile Pro Glu
Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 305 310 315 320 ctt gga
act cgt agg atg gca aag aaa aat gct atc gtt cga agt ctg 1548Leu Gly
Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 325 330 335
cct tct gtg gag acc ctt ggt tgt act tct gtt atc tgc tca gat aag
1596Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
340 345 350 aca ggc aca ctt acc aca aac cag atg tcc gtg tgc agg atg
ttc att 1644Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met
Phe Ile 355 360 365 ctg gac aaa gta gaa ggt gac act tgt tcc ctt aat
gag ttc agc ata 1692Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn
Glu Phe Ser Ile 370 375 380 act gga tcc aca tat gca cca att gga gaa
gtg caa aag gat gat aag 1740Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu
Val Gln Lys Asp Asp Lys 385 390 395 400 cca gtg aag tgc cat cag tat
gac ggg ctt gta gag tta gcc acc atc 1788Pro Val Lys Cys His Gln Tyr
Asp Gly Leu Val Glu Leu Ala Thr Ile 405 410 415 tgt gct ctg tgt aat
gac tct gct ttg gat tat aat gag gca aag ggt 1836Cys Ala Leu Cys Asn
Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 420 425 430 gtg tat gag
aaa gtt gga gaa gct acc gag act gct ctc acg tgc ctg 1884Val Tyr Glu
Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 435 440 445 gtg
gag aag atg aat gta ttt gat act gag ctg aag ggg ctt tct aaa 1932Val
Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 450 455
460 ata gag cgt gca aac gcc tgc aac tcg gtc ata aag cag ctg atg aag
1980Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys
465 470 475 480 aag gag ttc act ctg gag ttt tca cgg gat aga aaa tca
atg tcc gtc 2028Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser
Met Ser Val 485 490 495 tat tgt acc cca aac aag cca agc cgg aca tcc
atg agc aag atg ttt 2076Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser
Met Ser Lys Met Phe 500 505 510 gtg aag ggg gct cca gaa ggt gtc atc
gat agg tgc acc cac atc cga 2124Val Lys Gly Ala Pro Glu Gly Val Ile
Asp Arg Cys Thr His Ile Arg 515 520 525 gtt gga agt acc aag gtc ccc
atg act cct ggt gtc aaa cag aag att 2172Val Gly Ser Thr Lys Val Pro
Met Thr Pro Gly Val Lys Gln Lys Ile 530 535 540 atg tct gtc att cgg
gag tgg ggc agt ggc agc gac acg cta cgg tgc 2220Met Ser Val Ile Arg
Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 545 550 555 560 ctg gct
ctg gcc act cat gac aac cca ctg aag aga gag gag atg cac 2268Leu Ala
Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 565 570 575
ctg gaa gac tct gct aac ttc atc aaa tac gag acc aac ctg act ttc
2316Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe
580 585 590 gtc ggc tgt gtg ggc atg ctg gat cct ccc agg att gaa gta
gcc tct 2364Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val
Ala Ser 595 600 605 tct gtg aag ctg tgc cgg caa gca ggc atc cgg gtc
atc atg atc act 2412Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val
Ile Met Ile Thr 610 615 620 gga gac aac aaa ggc acc gct gtg gcc atc
tgt cgc cgc att ggc atc 2460Gly Asp Asn Lys Gly Thr Ala Val Ala Ile
Cys Arg Arg Ile Gly Ile 625 630 635 640 ttt ggg cag gat gag gat gtg
aca tca aag gct ttt aca ggg cga gag 2508Phe Gly Gln Asp Glu Asp Val
Thr Ser Lys Ala Phe Thr Gly Arg Glu 645 650 655 ttt gat gaa tta agc
cct tca gcc cag aga gat gcc tgc tta aat gcc 2556Phe Asp Glu Leu Ser
Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 660 665 670 cgc tgt ttt
gct cga gtt gaa cct tcc cac aag tct aag att gtt gag 2604Arg Cys Phe
Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 675 680 685 ttc
ctt cag tcc ttt gat gag atc aca gct atg act ggt gat ggt gtg 2652Phe
Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 690 695
700 aat gat gct cct gct ctg aag aaa tct gaa atc ggg att gcc atg ggc
2700Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly
705 710 715 720 tca ggg act gca gtg gct aag act gct tct gag atg gtc
ctg gca gat 2748Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val
Leu Ala Asp 725 730 735 gac aac ttc tcc acc att gtg gct gct gtt gag
gag ggg cga gcc atc 2796Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu
Glu Gly Arg Ala Ile 740 745 750 tac aac aac atg aag cag ttc atc cgc
tac ctc atc tca tcc aac gtg 2844Tyr Asn Asn Met Lys Gln Phe Ile Arg
Tyr Leu Ile Ser Ser Asn Val 755 760 765 ggg gaa gtg gtc tgt atc ttc
ctg acg gca gcc ctt ggg ttt cct gag 2892Gly Glu Val Val Cys Ile Phe
Leu Thr Ala Ala Leu Gly Phe Pro Glu 770 775 780 gct tta att cct gtc
cag tta ctc tgg gtc aat ctg gtg aca gat ggt 2940Ala Leu Ile Pro Val
Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 785 790 795 800 ctg cct
gcc act gcg ctg ggg ttc aat cct cca gac ctg gac atc atg 2988Leu Pro
Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 805 810 815
aac aaa ccc ccc cgg aac cca aaa gaa cca ctg atc agc ggg tgg ctc
3036Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu
820 825 830 ttt ttc cgt tac ctg gct att ggc tgt tat gtt ggc gct gcc
acc gtg 3084Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala
Thr Val 835 840 845 ggt gct gct gca tgg tgg ttc atc gct gct gac ggc
ggt cca aga gtc 3132Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly
Gly Pro Arg Val 850 855 860 tcc ttc tac cag ctg agt cat ttc cta cag
tgt aag gag gac aac cca 3180Ser Phe Tyr Gln Leu Ser His Phe Leu Gln
Cys Lys Glu Asp Asn Pro 865 870 875 880 gac ttc gat gga gtg gat tgt
gca atc ttt gag tcc cca tat cca atg 3228Asp Phe Asp Gly Val Asp Cys
Ala Ile Phe Glu Ser Pro Tyr Pro Met 885 890 895 aca atg gca ctt tct
gtt cta gta acc ata gag atg tgt aat gcc ctc 3276Thr Met Ala Leu Ser
Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 900 905 910 aac agc ttg
tct gaa aac cag tct ttg ctg agg atg ccc ccc tgg gag 3324Asn Ser Leu
Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 915 920 925 aat
atc tgg ctc gtg ggc tcc atc tgc ttg tcc atg tca ctt cac ttc 3372Asn
Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 930 935
940 ttg atc ctc tac gtg gaa cct ttg ccg ctc att ttc cag atc aca ccg
3420Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro
945 950 955 960 ctg aat ctg acc cag tgg ctg atg gtg ctg aaa atc tcc
ttg cct gtg 3468Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser
Leu Pro Val 965 970 975 atc ctc atg gat gag acg ctc aag ttt gtg gcc
cga aac tac ctg gaa 3516Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala
Arg Asn Tyr Leu Glu 980 985 990 caa ccc gca ata ctg gag taa
ccgcttccta aaccatttgc agaaatataa 3567Gln Pro Ala Ile Leu Glu 995
gggtgttcgg gtgcgtgcat gtgcgttgtt agcaacacat ctaccagccc tctgcatgac
3627tgaggttggg gaaaagaaaa atagaaacag tccccaactc actgtgtgat
gtggaggaaa 3687tgtgtattac cagtggggtt ttagctgttc aatcaaaata
ataacaaatg tacaatttag 3747cataacaaat cagagagcct ctccagagaa
gttggtttct ttgctgcgag aaggaggttc 3807tgaaacctta tccaagaaca
gaagccatca gccaagtctc cacatttctc tgcaaaatgt 3867catagcctct
ctaactgtat gataattgta atgcatgcct tcagttgtaa gtggccagat
3927tgctctacag tgacattgaa acatgctttc taatgggccc tgtacagttt
gcttatttat 3987aaattcattt aaaacactac agctgctgaa tggttacaac
ataggcctcc agtcctaact 4047tcagttgttt aggtgtgcag ccagctgttc
cacactgtat tattgtaact tatttaatga 4107agtcagaagc agtagacaga
tgttggtgca atacaagtat tgtgtgcatt tatcgtaata 4167aagtgctcag
cgtcagttca gttgctcaca gcttctcaca gcgcatgttt gactgtagtc
4227tgtaaataga ggtcagtttc tgtgctggta acaggtattg cacagacatg
atttcaggta 4287aataaatcta ttctacgata aaccctcaaa aaaaaaaaaa
aaaaaaaaaa aaaaaaaaaa 4347aaaaaa 43538998PRTMus musculus 8Met Glu
Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 1 5 10 15
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 20
25 30 Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys
Thr 35 40 45 Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu
Val Arg Ile 50 55 60 Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu
Ala Trp Phe Glu Glu 65 70 75 80 Gly Glu Glu Thr Ile Thr Ala Phe Val
Glu Pro Phe Val Ile Leu Leu 85 90 95 Ile Leu Val Ala Asn Ala Ile
Val Gly Val Trp Gln Glu Arg Asn Ala 100 105 110 Glu Asn Ala Ile Glu
Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 115 120 125 Val Tyr Arg
Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 130 135 140 Ile
Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 145 150
155 160 Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val
Asp 165 170 175 Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys
His Thr Asp 180 185 190 Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp
Lys Lys Asn Met Leu 195 200 205 Phe Ser Gly Thr Asn Ile Ala Ala Gly
Lys Ala Met Gly Val Val Val 210 215 220 Ala Thr Gly Val Asn Thr Glu
Ile Gly Lys Ile Arg Asp Glu Met Val 225 230 235 240 Ala Thr Glu Gln
Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 245 250 255 Gly Glu
Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 260 265 270
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 275
280 285 Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala
Val 290 295 300 Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr
Cys Leu Ala 305 310 315 320 Leu Gly Thr Arg Arg Met Ala Lys Lys Asn
Ala Ile Val Arg Ser Leu 325 330 335 Pro Ser Val Glu Thr Leu Gly Cys
Thr Ser Val Ile Cys Ser Asp Lys 340 345 350 Thr Gly Thr Leu Thr Thr
Asn Gln Met Ser Val Cys Arg Met Phe Ile 355 360 365 Leu Asp Lys Val
Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 370 375 380 Thr Gly
Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 385 390 395
400 Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
405 410 415 Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala
Lys Gly 420 425 430 Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala
Leu Thr Cys Leu 435 440 445 Val Glu Lys Met Asn Val Phe Asp Thr Glu
Leu Lys Gly Leu Ser Lys 450 455 460 Ile Glu Arg Ala Asn Ala Cys Asn
Ser Val Ile Lys Gln Leu Met Lys 465 470 475 480 Lys Glu Phe Thr Leu
Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 485 490 495 Tyr Cys Thr
Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 500 505 510 Val
Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 515 520
525 Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile
530 535 540 Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu
Arg Cys 545 550 555 560 Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys
Arg Glu Glu Met His 565 570 575 Leu Glu Asp Ser Ala Asn Phe Ile Lys
Tyr Glu Thr Asn Leu Thr Phe 580 585 590 Val Gly Cys Val Gly Met Leu
Asp Pro Pro Arg Ile Glu Val Ala Ser 595 600 605 Ser Val Lys Leu Cys
Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 610 615 620 Gly Asp Asn
Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 625 630 635 640
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 645
650 655 Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn
Ala 660 665 670 Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys
Ile Val Glu 675 680 685 Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met
Thr Gly Asp Gly Val 690 695 700 Asn Asp Ala Pro Ala Leu Lys Lys Ser
Glu Ile Gly Ile Ala Met Gly 705 710 715 720 Ser Gly Thr Ala Val Ala
Lys Thr Ala Ser Glu Met Val Leu Ala Asp 725 730 735 Asp Asn Phe Ser
Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 740 745 750 Tyr Asn
Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 755 760 765
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 770
775 780 Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp
Gly 785 790 795 800 Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp
Leu Asp Ile Met 805 810 815 Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro
Leu Ile Ser Gly Trp Leu 820 825 830 Phe Phe Arg
Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 835 840 845 Gly
Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 850 855
860 Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro
865 870 875 880 Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro
Tyr Pro Met 885 890 895 Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu
Met Cys Asn Ala Leu 900 905 910 Asn Ser Leu Ser Glu Asn Gln Ser Leu
Leu Arg Met Pro Pro Trp Glu 915 920 925 Asn Ile Trp Leu Val Gly Ser
Ile Cys Leu Ser Met Ser Leu His Phe 930 935 940 Leu Ile Leu Tyr Val
Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 945 950 955 960 Leu Asn
Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 965 970 975
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 980
985 990 Gln Pro Ala Ile Leu Glu 995 91078DNAHomo
sapiensmisc_featureHuman SUMO-1 polynucleotide 9gcggaagtga
cgcgaggcgt agcggaagtt actgcagccg cggtgttgtg ctgtggggaa 60gggagaagga
tttgtaaacc ccggagcgag gttctgctta cccgaggccg ctgctgtgcg
120gagacccccg ggtgaagcca ccgtcatcat gtctgaccag gaggcaaaac
cttcaactga 180ggacttgggg gataagaagg aaggtgaata tattaaactc
aaagtcattg gacaggatag 240cagtgagatt cacttcaaag tgaaaatgac
aacacatctc aagaaactca aagaatcata 300ctgtcaaaga cagggtgttc
caatgaattc actcaggttt ctctttgagg gtcagagaat 360tgctgataat
catactccaa aagaactggg aatggaggaa gaagatgtga ttgaagttta
420tcaggaacaa acggggggtc attcaacagt ttagttttaa aatttgaggg
tctggaccaa 480aagaagagga atatcaggtt gaagtcaaga tgacagataa
ggtgagagta atgactaact 540ccaaagatgg cttcactgaa gaaaaggcat
tttaagattt tttaaaaatc ttgtcagaag 600atcccagaaa agttctaatt
ttcattagca attaataaag ctatacatgc agaaatgaat 660acaacagaac
actgctcttt ttgattttat ttgtactttt tggcctggga tatgggtttt
720aaatggacat tgtctgtacc agcttcatta aaataaacaa tatttgtaaa
aatcatacta 780atgcttattt tattttaatt gtatagaaag aaaaaaatgc
ctaaaataag gttttcttgc 840ataaatactg gaaattgcac atggtacaaa
ttttttcttc attactgtac agtgatgatg 900ttaatgactt tgaagcactg
aaagttactg aagtgccttc tgaatcaagg atttaattaa 960ggccacaata
cctttttaat actcagtgtt ctgttttttt aaaaacttga tattcctgta
1020tggtgcatat atgatacagt tacctaatca tgttgaataa atgggcatgc caaaaatt
107810101PRTHomo sapiensMISC_FEATUREHuman SUMO-1 amino acid
sequence 10Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly
Asp Lys 1 5 10 15 Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly
Gln Asp Ser Ser 20 25 30 Glu Ile His Phe Lys Val Lys Met Thr Thr
His Leu Lys Lys Leu Lys 35 40 45 Glu Ser Tyr Cys Gln Arg Gln Gly
Val Pro Met Asn Ser Leu Arg Phe 50 55 60 Leu Phe Glu Gly Gln Arg
Ile Ala Asp Asn His Thr Pro Lys Glu Leu 65 70 75 80 Gly Met Glu Glu
Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 85 90 95 Gly His
Ser Thr Val 100 11306DNASus scrofamisc_featurePig SUMO-1
polynucleotide 11atgtctgacc aggaggcaaa accttcaact gaggacttgg
gtgataagaa ggaaggagag 60tacattaaac tcaaagtcat tggacaggat agcagtgaga
ttcacttcaa agtgaaaatg 120acgacacatc tcaagaaact caaagaatca
tactgtcaaa gacagggcgt tccaatgaat 180tcactcaggt ttctctttga
aggtcagaga attgctgata atcacactcc aaaagaactg 240ggaatggagg
aagaagatgt gattgaagtt tatcaggaac aaacaggggg tcactcaacg 300gtttag
30612101PRTSus scrofaMISC_FEATUREPig SUMO-1 amino acid sequence
12Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 1
5 10 15 Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser
Ser 20 25 30 Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys
Lys Leu Lys 35 40 45 Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met
Asn Ser Leu Arg Phe 50 55 60 Leu Phe Glu Gly Gln Arg Ile Ala Asp
Asn His Thr Pro Lys Glu Leu 65 70 75 80 Gly Met Glu Glu Glu Asp Val
Ile Glu Val Tyr Gln Glu Gln Thr Gly 85 90 95 Gly His Ser Thr Val
100 131150DNARattus norvegicusmisc_featureRat SUMO-1 polynucleotide
13ccgctgtggt gcggagaccc ccgggtgaat ccaccgacac catgtctgac caggaggcaa
60aaccttcaac tgaggactta ggagataaga aagaaggaga atacattaaa ctcaaagtta
120ttggacagga cagcagtgag atccatttca aagtgaaaat gacaacacat
ctcaagaagc 180tcaaagaatc gtactgtcaa agacagggag ttccaatgaa
ttcactcagg tttctctttg 240aaggtcagag aattgctgat aatcatactc
caaaagaact gggaatggag gaagaagacg 300tgattgaagt ttatcaggaa
caaacggggg gtcactcgac ggtttagata attcttttta 360ttttttattt
tttccttttc cctcaatcct tttttatttt taaaaatagt tcttttgtaa
420tgtggtgttc aaaatgaaaa ttgaatactg gcactccatc tcttagaaca
tctggtaatc 480tgaattctag tgttcaatat tcattattgg ttgtttttgt
tgtgctgatt tttggtgatc 540agacctcagc tcccttaaca ttgcccttct
tcctttaaga gatttcatgt gtgcacacag 600agaggccacc ctttccagga
ctgtgcattt tcagggttgt gatgataaaa ggatcgacta 660atgggagctt
ccctgtgacc tttcaatggc cctgcagttc cggtatgtgg ttgcttcact
720cctggactat gattttcagt gggagatgga gatttttcag agaaccgaac
tgtggaaaat 780gaccttttct cagcttgaag ctacttttaa aatctgaggg
tctggaccaa aagaagaaca 840tcatgtttgt agtcaaggta acagatacag
tgagagtaac agctaactcc aaaagtggct 900tcactggaga gaaagaaagt
gtcttgagca agacagtatt gtcagaagat cccaggaaag 960ttctaatctt
catcagcagt taataataaa gttactcata cagaagtgta cgcaacagac
1020actgctcctt ttgattctgt tgtacttttt ggcctgggac atgggttttc
aagggacatc 1080atctgtacca gcttcattaa aataaacaat atttgtaaaa
accgtaaaaa aaaaaaaaaa 1140aaaaaaaaaa 115014101PRTRattus
norvegicusMISC_FEATURERat SUMO-1 amino acid sequence 14Met Ser Asp
Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 1 5 10 15 Lys
Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 20 25
30 Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys
35 40 45 Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu
Arg Phe 50 55 60 Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr
Pro Lys Glu Leu 65 70 75 80 Gly Met Glu Glu Glu Asp Val Ile Glu Val
Tyr Gln Glu Gln Thr Gly 85 90 95 Gly His Ser Thr Val 100
151230DNAMus musculusmisc_featureMouse SUMO-1 polynucleotide
15ggaagtgacg caagacgtag aggaagtccc tgcagccgcg gtgttgtgct gtagagaagg
60gacggatttg taaacctcag agtgaggttc tgcctgccgg aggccgcagt ggtgcggaga
120cccccgggtg aatccacgtc accatgtctg accaggaggc aaaaccttca
actgaggact 180taggcgataa gaaggaagga gaatacatta aactcaaagt
tattggacag gatagcagtg 240agatacattt caaagtgaaa atgacaacac
atctcaagaa actcaaagaa tcatactgtc 300aaagacaggg agttccaatg
aattcactca ggtttctctt tgaaggtcag agaattgctg 360ataatcatac
tccgaaagaa ctgggaatgg aggaagaaga tgtgattgaa gtttatcagg
420aacaaacggg gggtcactcg acggtttaga taattctttt tattttttat
ttttcctttc 480cctcaatcct tttttatttt taaaaatagt tcttttgtaa
tgtggtgttc aaaatgaaaa 540ttgaatactg gcactccatc tcttagaaca
tatgaattct agtgttcaat attcattatt 600ggttgttttt gttgtgctga
tttttggtga tcagacctca gctcccttaa tactgccctt 660tttcctttaa
gagatttcat gtgtgcacag agaggccacc cttttcagga ctgtgcattt
720tcaggtttgt gatgataaaa agatcgacca atgggagctt tcctatgacc
tttcaattgg 780ctctgaagtt ccagcatgtg gttgcttcac tcctggactg
tgattttcag tgggagatgg 840aaatttttca gagaactgaa ctgtggaaaa
tgacctttcc tcagcttgaa gctactttta 900aaatctgcgg gtctggacca
aaagaagaac atcatgtttg tagtcaagat gacagataca 960gtgagagcaa
cagctaactc caaaggtggc ttcactggag agaaagaaag tgtcttgagc
1020aagacagtat tgtcagaaga tcccaggaaa gttctaatgt tcatcagcag
ttattaataa 1080agttactcat acagaagtgt acgcaacaga cactgctttt
gattctgttt gtactttttg 1140gcctgggaca tgggttttca agggacatcg
tctgtaccag cttcattaaa ataaacaata 1200tttgtaaaaa cattaaaaaa
aaaaaaaaaa 123016101PRTMus musculusMISC_FEATUREMouse SUMO-1 amino
acid sequence 16Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu
Gly Asp Lys 1 5 10 15 Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile
Gly Gln Asp Ser Ser 20 25 30 Glu Ile His Phe Lys Val Lys Met Thr
Thr His Leu Lys Lys Leu Lys 35 40 45 Glu Ser Tyr Cys Gln Arg Gln
Gly Val Pro Met Asn Ser Leu Arg Phe 50 55 60 Leu Phe Glu Gly Gln
Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 65 70 75 80 Gly Met Glu
Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 85 90 95 Gly
His Ser Thr Val 100
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