U.S. patent application number 14/753457 was filed with the patent office on 2015-10-22 for process for production of acrylates from epoxides.
The applicant listed for this patent is Novomer, Inc.. Invention is credited to Jay J. Farmer, Robert E. Lapointe, Richard V. Porcelli.
Application Number | 20150299083 14/753457 |
Document ID | / |
Family ID | 48168463 |
Filed Date | 2015-10-22 |
United States Patent
Application |
20150299083 |
Kind Code |
A1 |
Porcelli; Richard V. ; et
al. |
October 22, 2015 |
PROCESS FOR PRODUCTION OF ACRYLATES FROM EPOXIDES
Abstract
In one aspect, the present invention encompasses integrated
processes for the conversion of epoxides to acrylic acid
derivatives and polyesters. In certain embodiments, the methods of
the present invention comprise the steps of: providing a feedstock
stream comprising an epoxide and carbon monoxide; contacting the
feedstock stream with a metal carbonyl in a first reaction zone to
effect conversion of at least a portion of the provided epoxide to
a beta lactone; directing the effluent from the first reaction zone
to a second reaction zone where the beta lactone is subjected to
conditions that convert it to a compound selected from the group
consisting of: an alpha beta unsaturated acid, an alpha beta
unsaturated ester, an alpha beta unsaturated amide, and an
optionally substituted polypropiolactone polymer; and isolating a
final product comprising the alpha-beta unsaturated carboxylic
acid, the alpha-beta unsaturated ester, the alpha-beta unsaturated
amide or the polypropiolactone.
Inventors: |
Porcelli; Richard V.;
(Ithaca, NY) ; Farmer; Jay J.; (Ithaca, NY)
; Lapointe; Robert E.; (Ithaca, NY) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
Novomer, Inc. |
Ithaca |
NY |
US |
|
|
Family ID: |
48168463 |
Appl. No.: |
14/753457 |
Filed: |
June 29, 2015 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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14353532 |
Apr 23, 2014 |
9096510 |
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PCT/US12/61791 |
Oct 25, 2012 |
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14753457 |
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61551496 |
Oct 26, 2011 |
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Current U.S.
Class: |
528/357 ;
560/211; 562/599 |
Current CPC
Class: |
C07C 67/475 20130101;
C08G 63/81 20130101; C08G 63/823 20130101; C08G 63/82 20130101;
C07C 67/03 20130101; C08G 63/06 20130101; Y02P 20/10 20151101; C07C
51/12 20130101; C07C 51/09 20130101; C08G 63/08 20130101; C07D
305/12 20130101; Y02P 20/125 20151101; C07C 67/36 20130101; C07D
301/08 20130101; C07C 51/09 20130101; C07C 57/04 20130101; C07C
67/03 20130101; C07C 69/54 20130101 |
International
Class: |
C07C 51/09 20060101
C07C051/09; C08G 63/06 20060101 C08G063/06; C07C 67/475 20060101
C07C067/475; C08G 63/82 20060101 C08G063/82; C07D 305/12 20060101
C07D305/12; C07D 301/08 20060101 C07D301/08; C08G 63/08 20060101
C08G063/08; C08G 63/81 20060101 C08G063/81 |
Claims
1. A method for the synthesis of acrylic acid comprising the steps
of: providing a gaseous feedstock stream comprising ethylene oxide
and carbon monoxide; directing the feedstock stream to a first
reaction zone where it is contacted with a metal carbonyl compound
and where at least a portion of the ethylene oxide is converted to
a carbonylation product stream comprising beta propiolactone;
directing the carbonylation product stream to a second reaction
zone where it is contacted with a catalyst, which catalyzes the
conversion of beta propiolactone to acrylic acid; withdrawing an
acrylic acid product stream from the second reaction zone; and
isolating acrylic acid from the product stream.
2. The method of claim 1, further comprising the step of adding
water to the carbonylation product stream before it enters the
second reaction zone.
3. The method of claim 1, wherein the conversion of ethylene oxide
to beta propiolactone is a gas phase reaction.
4. The method of claim 1, wherein the metal carbonyl compound has a
formula [QM.sub.y(CO).sub.w].sup.x, where: Q is any ligand or more
than one ligand and need not be present; M is a metal atom; y is an
integer from 1 to 6 inclusive; w is a number such as to provide the
stable metal carbonyl; and x is an integer from -3 to +3
inclusive.
5. The method of claim 1, wherein the metal carbonyl compound
comprises an anionic metal carbonyl.
6. The method of claim 5, wherein the anionic metal carbonyl
compound comprises a moiety selected from the group consisting of:
[Co(CO).sub.4].sup.-, [Ti(CO).sub.6].sup.2-, [V(CO).sub.6].sup.-,
[Rh(CO).sub.4].sup.-, [Fe(CO).sub.4].sup.2-, [Ru(CO).sub.4].sup.2-,
[Os(CO).sub.4].sup.2-, [Cr.sub.2(CO).sub.10].sup.2-,
[Fe.sub.2(CO).sub.8].sup.2-, [Tc(CO).sub.5].sup.-,
[Re(CO).sub.5].sup.-, and [Mn(CO).sub.5].sup.-.
7. The method of claim 5, wherein the anionic metal carbonyl
compound comprises [Co(CO).sub.4].sup.-.
8. The method of claim 5, wherein the anionic metal carbonyl
compound comprises [Rh(CO).sub.4].sup.-.
9. The method of claim 1, wherein the metal carbonyl compound
comprises a neutral metal carbonyl compound.
10. The method of claim 9, wherein the neutral metal carbonyl
compound is selected from the group consisting of: Ti(CO).sub.7;
V.sub.2(CO).sub.12; Cr(CO).sub.6; Mo(CO).sub.6; W(CO).sub.6
Mn.sub.2(CO).sub.10, Tc.sub.2(CO).sub.10, Re.sub.2(CO).sub.10
Fe(CO).sub.5, Ru(CO).sub.5 Os(CO).sub.5 Ru.sub.3(CO).sub.12,
Os.sub.3(CO).sub.12 Fe.sub.3(CO).sub.12 Fe.sub.2(CO).sub.9
Co.sub.4(CO).sub.12, Rh.sub.4(CO).sub.12, Rh.sub.6(CO).sub.16,
Ir.sub.4(CO).sub.12, Co.sub.2(CO).sub.8, and Ni(CO).sub.4.
11. The method of claim 9, wherein the neutral metal carbonyl
compound comprises Co.sub.2(CO).sub.8.
12. The method of claim 1, wherein the metal carbonyl compound
comprises a solid.
13. The method of claim 1, wherein the metal carbonyl compound is
supported on a solid.
14. The method of claim 13, wherein the solid support is selected
from the group consisting of inorganic solids and polymer
supports.
15. The method of claim 13, wherein the solid support is selected
from the group consisting of: silica, glass, alumina, zirconia,
diatomaceous earth, metal oxides, metal salts, ceramics, clays,
molecular sieves, kieselgur, and titanium dioxide.
16. The method of claim 13, herein the solid support is selected
from the group consisting of silica gel, alumina, and glass.
17. The method of claim 1, wherein the ratio of carbon monoxide to
ethylene oxide in the feedstock stream is between about 1:1 and
about 100:1.
18. The method of claim 1, wherein the ratio of carbon monoxide to
ethylene oxide in the feedstock stream is greater than about
10:1.
19. The method of claim 1, wherein the feedstock stream is provided
to the first reaction zone at a pressure between about 20 and about
200 atmospheres.
20. The method of claim 1, wherein the feedstock stream is provided
to the first reaction zone at a temperature between about 50 and
about 200.degree. C.
21. The method of claim 1, where the catalyst in the second
reaction zone comprises an acid.
22. The method of claim 21, wherein the acid comprises phosphoric
acid.
23. The method of claim 21, wherein the acid comprises a solid acid
catalyst.
24. The method of claim 1, wherein the carbonylation product stream
is provided to the second reaction zone as a gaseous stream.
25. The method of claim 24, wherein the carbonylation product
stream comprises a mixture of beta propiolactone and carbon
monoxide.
26. The method of claim 24, wherein the carbonylation product
stream is essentially free of unreacted ethylene oxide.
27. The method of claim 1, wherein the step of isolating the
acrylic acid comprises condensing the acrylic acid.
28. The method of claim 1, further comprising the step of oxidizing
ethylene gas to provide the ethylene oxide feedstock stream.
29. The method of claim 28, wherein the step of oxidizing ethylene
gas comprises contacting ethylene with oxygen in an ethylene
oxidation reactor in the presence of a suitable catalyst to convert
at least a portion of the ethylene to ethylene oxide, withdrawing a
gaseous ethylene oxide stream from the ethylene oxidation reactor;
and combining the gaseous ethylene oxide stream with carbon
monoxide to provide the feedstock stream.
30. A method for the synthesis of acrylate esters comprising the
steps of: providing a gaseous feedstock stream comprising ethylene
oxide and carbon monoxide; directing the feedstock stream to a
first reaction zone where it is contacted with a metal carbonyl
compound and where at least a portion of the ethylene oxide is
converted to a product stream comprising beta propiolactone; adding
a C.sub.1-8 alcohol to the product stream comprising beta
propiolactone; directing the product stream comprising beta
propiolactone and the C.sub.1-8 alcohol to a second reaction zone
where it is contacted with a catalyst which catalyzes the
conversion of beta propiolactone and the C.sub.1-8 alcohol to the
corresponding acrylic acid ester; withdrawing an acrylic acid ester
product stream from the second reaction zone; and isolating an
acrylate ester from the product stream.
31. The method of claim 30, wherein the C.sub.1-8 alcohol is
selected from the group consisting of methanol, ethanol, propanol,
butanol, hexanol, and 2-ethyl hexanol.
32. The method of claim 30, wherein the C.sub.1-8 alcohol comprises
methanol.
33. The method of claim 30, wherein the C.sub.1-8 alcohol comprises
butanol.
34. A method for the synthesis of polypropiolactone comprising the
steps of: providing a gaseous feedstock stream comprising ethylene
oxide and carbon monoxide; directing the feedstock stream to a
first reaction zone where it is contacted with a metal carbonyl
compound and at least a portion of the ethylene oxide is converted
to a product stream comprising beta propiolactone; directing the
product stream comprising beta propiolactone to a polymerization
reactor containing a suitable solvent and a polymerization
catalyst; withdrawing a polypropiolactone product stream from the
polymerization reactor; and isolating polypropiolactone from the
product stream.
35. A method for the synthesis of poly-3-hydroxybutyrate comprising
the steps of: providing a gaseous feedstock stream comprising
enantio-enriched propylene oxide and carbon monoxide; directing the
feedstock stream to a first reaction zone where it is contacted
with a metal carbonyl compound and at least a portion of the
propylene oxide is converted to a product stream comprising beta
butyrolactone; directing the product stream comprising beta
butyrolactone to a polymerization reactor containing a solvent and
a polymerization catalyst; withdrawing a poly-3-hydroxybutyrate
product stream from the polymerization reactor; and isolating
poly-3-hydroxybutyrate from the product stream.
36. The method of any of claim 30, 34, or 35, wherein the metal
carbonyl compound comprises a solid.
37. The method of any of claim 30, 34, or 35, wherein the metal
carbonyl compound is supported on a solid.
38. The method of any of claim 30, 34, or 35, wherein the solid
support is selected from the group consisting of inorganic solids
and polymer supports.
39. The method of any of claim 30, 34, or 35, wherein the solid
support is selected from the group consisting of: silica, glass,
alumina, zirconia, diatomaceous earth, metal oxides, metal salts,
ceramics, clays, molecular sieves, kieselgur, and titanium
dioxide.
40. A method for the synthesis of acrylic acid comprising the steps
of: providing an ethylene stream; contacting the ethylene stream
with oxygen in the presence of a catalyst to provide an ethylene
oxide stream; adding carbon monoxide to the ethylene oxide stream
to provide a feedstock stream; directing the feedstock stream to a
first reaction zone where it is contacted with a metal carbonyl
compound and where at least a portion of the ethylene oxide is
converted to a carbonylation product stream comprising beta
propiolactone; directing the carbonylation product stream to a
second reaction zone where it is contacted with a catalyst, which
catalyzes the conversion of beta propiolactone to acrylic acid;
withdrawing an acrylic acid product stream from the second reaction
zone; and isolating acrylic acid from the product stream.
41. The method of claim 40, wherein the ethylene oxide remains
substantially in the gas phase between the oxidation step and the
first reaction zone.
Description
FIELD OF THE INVENTION
[0001] The invention pertains to the field of chemical synthesis.
More particularly, the invention pertains to an integrated process
for the production of acrylic acid and its derivatives by
carbonylation of epoxide feedstocks.
BACKGROUND OF THE INVENTION
[0002] Beta lactones are a class of chemical compounds that have
great industrial potential
[0003] For example, beta lactones (e.g., beta propiolactone (BPL))
can undergo reactions to produce valued chemical derivatives,
including 3-hydroxypropionic acid and its esters, propanediol,
acrylic acid, acrylate esters and amides, succinic anhydride,
succinic acid, butanediol, polypropiolactone biodegradable
polymers, and others. It also has some industrial uses itself as a
specialty disinfectant to sterilize medical products.
[0004] However, since beta propiolactone has been difficult to
manufacture in a selective and high yielding fashion and because it
has been found to be a probable human carcinogen, the use of this
highly interesting and reactive chemical intermediate is limited.
Some previous commercial applications which otherwise represented
economically attractive processes, such as the manufacture of
acrylic acid and its esters, have been phased out in favor of other
alternatives. In the case of acrylic acid manufacture, the industry
has turned to propylene oxidation. For many years propylene was a
low cost feedstock and alternate routes to acrylic acid were of
little interest. However because propylene production is tightly
tied to petroleum refining its price fluctuates with crude oil
prices. Propylene availability is further impacted by demands for
other product in the refiningetroleum industry. As a result
propylene prices have risen sharply in recent years. This dynamic
has prompted interest in alternate routes to acrylic acid. The use
of ethylene oxide (EO) as a feedstock for acrylic acid is
increasingly attractive since EO can be derived from inexpensive
ethylene sourced from natural gas production. Carbonylation of EO
can provide beta propiolactone in excellent yield and selectivity,
however the problems of handling and transporting this toxic
chemical still remain.
[0005] In order to take advantage of the unique chemical properties
of beta propiolactone, which is just one example of the class of
similar lactones which includes beta butyrolactone and other
interesting lactone chemical intermediates, it is desired to
develop integrated processes in which the purification or isolation
of beta propiolactone is avoided.
[0006] It is therefore a broad object of this invention to provide
the integrated production and conversion of beta lactones, without
their intermediate separation, with the aim of avoiding the
potential exposure to the hazards of some of the class of lactones,
while at the same time providing economically advantagous
production processes.
[0007] Commercially, beta propiolactone has in the past been
produced by the reaction of ketene with formaldehyde. The
production of ketene is based on the high temperature
(700-750.degree. C.) thermal dissociation of acetic acid in the
presence of triethyl phosphate under a reduced pressure. This
ketene process is mechanically complex, highly energy intensive and
is a source of unwanted emissions to the atmosphere. After
isolation, highly reactive monomeric ketene can be reacted with
aldehydes to form beta lactones in the presence of aluminum
chloride catalyst, commonly referred to as a Friedal-Crafts
catalyst.
[0008] Reaction of ketene and formaldehyde yields beta
propiolactone. Reaction with acetaldehyde produces beta
butyrolactone, while reaction with crotonaldehyde forms a polyester
which is then thermally decomposed to sorbic acid. The aluminum
chloride itself has many hazards it use, including potentially
violent reactions of anhydrous aluminum chloride with water or
bases. This very active catalyst also results in the formation of a
number of unwanted byproducts that must be separated and removed
from the desired lactone product leading to further handling
challenges and additional opportunities for worker exposure. A
general problem with the use of aluminum chloride Friedal-Crafts
catalyst is that it is often consumed in the reaction, is very
difficult to recover and regenerate, and commonly must be destroyed
after use, generating a large amount of corrosive waste.
[0009] Therefore, it is advantageous to rely on a better process
for the production of beta lactones, and more particularly the
intermediate, beta propiolactone, by the carbonylation of the
corresponding epoxide, particularly ethylene oxide in the case of
beta propiolactone.
SUMMARY OF THE INVENTION
[0010] In certain embodiments, the present invention provides
methods for the production of derivatives of beta lactones (e.g.,
beta propiolactone) by integrating their production, for example by
the carbonylation of ethylene oxide, with the conversion of beta
propiolactone to acrylic acid, as one example of a number of
possible valued derivatives. In certain embodiments, the invention
provides integrated processes for the conversion of ethylene oxide
and carbon monoxide to acrylic acid and its esters without the need
to isolate beta propiolactone as a separate intermediate
product.
[0011] Applied to epoxides, such as ethylene oxide, carbonylation
results in the simultaneous opening of the epoxide ring and the
addition of carbon in the form of a carbonyl (C.dbd.O) functional
group, resulting in the formation of a beta propiolactone by the
general reaction
##STR00001##
[0012] Examples include: [0013] propylene oxide+CO.fwdarw.beta
butyrolactone
[0013] ##STR00002## [0014] ethylene oxide+CO.fwdarw.beta
propiolactone
##STR00003##
[0015] The carbonylation of epoxides can be catalyzed by metal
carbonyls, most commonly Group VIII carbonyls and, in particular
carbonyls of cobalt, at modest temperature and pressure. The
carbonylation reaction can be run in the liquid phase with either a
homogeneous (i.e., soluble) catalyst complex, or with a
heterogeneous (i.e., active cobalt carbonyl fixed on a solid
support) catalyst. The reaction can also be run in the vapor phase,
using a heterogeneous, supported form of the cobalt catalyst.
[0016] If the goal is the production of acrylic acid or acrylate
esters, beta propiolactone undergoes thermolysis or alcoholysis
respectively. One example is to react beta propiolactone with
phosphoric acid using a copper powder catalyst at 140-180.degree.
C. and 25-250 bar to quantitatively form acrylic acid--this
reaction is sometimes catalyzed by water. If the same reaction is
run in the presence of an alcohol, the corresponding acrylate ester
is formed directly. The thermolysis of beta propiolactone was in
fact used as the basis for Celanese Corporation's production of
about 35,000 tons/year of purified acrylic acid and its esters
between 1957 and 1974. In that example, beta propiolactone was
first isolated from the product of the reaction of formaldehyde
with ketene, with the potential of worker exposure and
environmental release of the hazardous intermediate, as the
requirement of a high purity of final acrylic acid or acrylate
ester product mandated the purification of the intermediate beta
propiolactone to a high specification.
[0017] This invention makes it possible to eliminate the hazards
and costs associated with isolating the intermediate lactone by
choosing the appropriate carbonylation and thermolysis process and
conditions to allow a direct linking of the two reaction steps.
[0018] In certain embodiments, the process of this invention can
also be directly integrated to the formation of ethylene oxide,
thus avoiding the isolation and storage of this toxic and
potentially explosive intermediate. In certain embodiments, the
processes of the present invention are fed by ethylene gas which is
converted to ethylene oxide in a first reaction zone, the ethylene
oxide from the first zone then feeds a second reaction zone where
carbonylation takes place to yield BPL, the effluent from the
second reaction zone is then fed to a third stage where the BPL is
converted to acrylic acid or related acrylate derivatives.
[0019] In certain embodiments, the present invention provides a
method for the synthesis of acrylic acid comprising the steps of:
[0020] providing a gaseous feedstock stream comprising ethylene
oxide and carbon monoxide; [0021] directing the feedstock stream to
a first reaction zone where it is contacted with a metal carbonyl
compound and where at least a portion of the ethylene oxide is
converted to a carbonylation product stream comprising beta
propiolactone; [0022] directing the carbonylation product stream to
a second reaction zone where it is contacted with a catalyst which
catalyzes the conversion of beta propiolactone to acrylic acid;
[0023] withdrawing an acrylic acid product stream from the second
reaction zone; and [0024] isolating acrylic acid from the product
stream.
[0025] In other embodiments, the present invention provides a
method for the synthesis of polypropiolactone comprising the steps
of: [0026] providing a gaseous feedstock stream comprising ethylene
oxide and carbon monoxide; [0027] directing the feedstock stream to
a first reaction zone where it is contacted with a metal carbonyl
compound and at least a portion of the ethylene oxide is converted
to a product stream comprising beta propiolactone; [0028] directing
the product stream comprising beta propiolactone to a
polymerization reactor containing a suitable optional solvent and a
polymerization catalyst; [0029] withdrawing a polypropiolactone
product stream from the polymerization reactor; and [0030]
isolating polypropiolactone from the product stream.
[0031] In another embodiment, the present invention provides a
method for the synthesis of poly-3-hydroxybutyrate comprising the
steps of: [0032] providing a gaseous feedstock stream comprising
enantio-enriched propylene oxide and carbon monoxide; [0033]
directing the feedstock stream to a first reaction zone where it is
contacted with a metal carbonyl compound and at least a portion of
the propylene oxide is converted to a product stream comprising
beta butyrolactone; [0034] directing the product stream comprising
beta butyrolactone to a polymerization reactor containing an
optional solvent and a polymerization catalyst; [0035] withdrawing
a poly-3-hydroxybutyrate product stream from the polymerization
reactor; and [0036] isolating poly-3-hydroxybutyrate from the
product stream.
BRIEF DESCRIPTION OF THE DRAWINGS
[0037] FIG. 1 shows a process schematic for production of beta
lactone from an epoxide using a supported catalyst.
[0038] FIG. 2 shows a process schematic for production of beta
lactone from an epoxide using a supported catalyst with a provision
for capturing unreacted feedstocks downstream of the carbonylation
reactor.
DEFINITIONS
[0039] Definitions of specific functional groups and chemical terms
are described in more detail below. For purposes of this invention,
the chemical elements are identified in accordance with the
Periodic Table of the Elements, CAS version, Handbook of Chemistry
and Physics, 75.sup.th Ed., inside cover, and specific functional
groups are generally defined as described therein. Additionally,
general principles of organic chemistry, as well as specific
functional moieties and reactivity, are described in Organic
Chemistry, Thomas Sorrell, University Science Books, Sausalito,
1999; Smith and March March's Advanced Organic Chemistry, 5.sup.th
Edition, John Wiley & Sons, Inc., New York, 2001; Larock,
Comprehensive Organic Transformations, VCH Publishers, Inc., New
York, 1989; Carruthers, Some Modern Methods of Organic Synthesis,
3.sup.rd Edition, Cambridge University Press, Cambridge, 1987; the
entire contents of each of which are incorporated herein by
reference.
[0040] Certain compounds of the present invention can comprise one
or more asymmetric centers, and thus can exist in various
stereoisomeric forms, e.g., enantiomers and/or diastereomers. Thus,
inventive compounds and compositions thereof may be in the form of
an individual enantiomer, diastereomer or geometric isomer, or may
be in the form of a mixture of stereoisomers. In certain
embodiments, the compounds of the invention are enantiopure
compounds. In certain embodiments, mixtures of enantiomers or
diastereomers are provided.
[0041] Furthermore, certain compounds, as described herein may have
one or more double bonds that can exist as either the Z or E
isomer, unless otherwise indicated. The invention additionally
encompasses the compounds as individual isomers substantially free
of other isomers and alternatively, as mixtures of various isomers,
e.g., racemic mixtures of enantiomers.
[0042] As used herein, the term "isomers" includes any and all
geometric isomers and stereoisomers. For example, "isomers" include
cis- and trans-isomers, E- and Z-isomers, R- and S-enantiomers,
diastereomers, (D)-isomers, (L)-isomers, racemic mixtures thereof,
and other mixtures thereof, as falling within the scope of the
invention. For instance, an stereoisomer may, in some embodiments,
be provided substantially free of one or more corresponding
stereoisomers, and may also be referred to as "stereochemically
enriched."
[0043] Where a particular enantiomer is preferred, it may, in some
embodiments be provided substantially free of the opposite
enantiomer, and may also be referred to as "optically enriched."
"Optically enriched," as used herein, means that the compound is
made up of a significantly greater proportion of one enantiomer. In
certain embodiments the compound is made up of at least about 90%
by weight of a preferred enantiomer. In other embodiments the
compound is made up of at least about 95%, 98%, or 99% by weight of
a preferred enantiomer. Preferred enantiomers may be isolated from
racemic mixtures by any method known to those skilled in the art,
including chiral high pressure liquid chromatography (HPLC) and the
formation and crystallization of chiral salts or prepared by
asymmetric syntheses. See, for example, Jacques, et al.,
Enantiomers, Racemates and Resolutions (Wiley Interscience, New
York, 1981); Wilen, S. H., et al., Tetrahedron 33:2725 (1977);
Eliel, E. L. Stereochemistry of Carbon Compounds (McGraw-Hill, NY,
1962); Wilen, S. H. Tables of Resolving Agents and Optical
Resolutions p. 268 (E. L. Eliel, Ed., Univ. of Notre Dame Press,
Notre Dame, Ind. 1972).
[0044] The terms "halo" and "halogen" as used herein refer to an
atom selected from fluorine (fluoro, --F), chlorine (chloro, --Cl),
bromine (bromo, --Br), and iodine (iodo, --I).
[0045] The term "aliphatic" or "aliphatic group", as used herein,
denotes a hydrocarbon moiety that may be straight-chain (i.e.,
unbranched), branched, or cyclic (including fused, bridging, and
spiro-fused polycyclic) and may be completely saturated or may
contain one or more units of unsaturation, but which is not
aromatic. Unless otherwise specified, aliphatic groups contain 1-30
carbon atoms. In certain embodiments, aliphatic groups contain 1-12
carbon atoms. In certain embodiments, aliphatic groups contain 1-8
carbon atoms. In certain embodiments, aliphatic groups contain 1-6
carbon atoms. In some embodiments, aliphatic groups contain 1-5
carbon atoms. In some embodiments, aliphatic groups contain 1-4
carbon atoms. In some embodiments, aliphatic groups contain 1-3
carbon atoms. In some embodiments, aliphatic groups contain 1-2
carbon atoms. Suitable aliphatic groups include, but are not
limited to, linear or branched, alkyl, alkenyl, and alkynyl groups,
and hybrids thereof such as (cycloalkyl)alkyl, (cycloalkenyl)alkyl
or (cycloalkyl)alkenyl.
[0046] The term "unsaturated", as used herein, means that a moiety
has one or more double or triple bonds.
[0047] The terms "cycloaliphatic", "carbocycle", or "carbocyclic",
used alone or as part of a larger moiety, refer to a saturated or
partially unsaturated cyclic aliphatic monocyclic or bicyclic ring
systems, as described herein, having from 3 to 12 members, wherein
the aliphatic ring system is optionally substituted as defined
above and described herein. Cycloaliphatic groups include, without
limitation, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl,
cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, cyclooctyl,
cyclooctenyl, and cyclooctadienyl. In some embodiments, the
cycloalkyl has 3-6 carbons. The terms "cycloaliphatic",
"carbocycle" or "carbocyclic" also include aliphatic rings that are
fused to one or more aromatic or nonaromatic rings, such as
decahydronaphthyl or tetrahydronaphthyl, where the radical or point
of attachment is on the aliphatic ring. In certain embodiments, the
term "3- to 8-membered carbocycle" refers to a 3- to 8-membered
saturated or partially unsaturated monocyclic carbocyclic ring. In
certain embodiments, the terms "3- to 14-membered carbocycle" and
"C.sub.3-14 carbocycle" refer to a 3- to 8-membered saturated or
partially unsaturated monocyclic carbocyclic ring, or a 7- to
14-membered saturated or partially unsaturated polycyclic
carbocyclic ring. In certain embodiments, the term "C.sub.3-20
carbocycle" refers to a 3- to 8-membered saturated or partially
unsaturated monocyclic carbocyclic ring, or a 7- to 20-membered
saturated or partially unsaturated polycyclic carbocyclic ring.
[0048] The term "alkyl," as used herein, refers to saturated,
straight- or branched-chain hydrocarbon radicals derived from an
aliphatic moiety containing between one and six carbon atoms by
removal of a single hydrogen atom. Unless otherwise specified,
alkyl groups contain 1-12 carbon atoms. In certain embodiments,
alkyl groups contain 1-8 carbon atoms. In certain embodiments,
alkyl groups contain 1-6 carbon atoms. In some embodiments, alkyl
groups contain 1-5 carbon atoms. In some embodiments, alkyl groups
contain 1-4 carbon atoms. In certain embodiments, alkyl groups
contain 1-3 carbon atoms. In some embodiments, alkyl groups contain
1-2 carbon atoms. Examples of alkyl radicals include, but are not
limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, iso-butyl,
sec-butyl, sec-pentyl, iso-pentyl, tert-butyl, n-pentyl, neopentyl,
n-hexyl, sec-hexyl, n-heptyl, n-octyl, n-decyl, n-undecyl, dodecyl,
and the like.
[0049] The term "alkenyl," as used herein, denotes a monovalent
group derived from a straight- or branched-chain aliphatic moiety
having at least one carbon-carbon double bond by the removal of a
single hydrogen atom. Unless otherwise specified, alkenyl groups
contain 2-12 carbon atoms. In certain embodiments, alkenyl groups
contain 2-8 carbon atoms. In certain embodiments, alkenyl groups
contain 2-6 carbon atoms. In some embodiments, alkenyl groups
contain 2-5 carbon atoms. In some embodiments, alkenyl groups
contain 2-4 carbon atoms. In some embodiments, alkenyl groups
contain 2-3 carbon atoms. In some embodiments, alkenyl groups
contain 2 carbon atoms. Alkenyl groups include, for example,
ethenyl, propenyl, butenyl, 1-methyl-2-buten-1-yl, and the
like.
[0050] The term "alkynyl," as used herein, refers to a monovalent
group derived from a straight- or branched-chain aliphatic moiety
having at least one carbon-carbon triple bond by the removal of a
single hydrogen atom. Unless otherwise specified, alkynyl groups
contain 2-12 carbon atoms. In certain embodiments, alkynyl groups
contain 2-8 carbon atoms. In certain embodiments, alkynyl groups
contain 2-6 carbon atoms. In some embodiments, alkynyl groups
contain 2-5 carbon atoms. In some embodiments, alkynyl groups
contain 2-4 carbon atoms. In some embodiments, alkynyl groups
contain 2-3 carbon atoms. In some embodiments, alkynyl groups
contain 2 carbon atoms. Representative alkynyl groups include, but
are not limited to, ethynyl, 2-propynyl (propargyl), 1-propynyl,
and the like.
[0051] The term "aryl" used alone or as part of a larger moiety as
in "aralkyl", "aralkoxy", or "aryloxyalkyl", refers to monocyclic
and polycyclic ring systems having a total of five to 20 ring
members, wherein at least one ring in the system is aromatic and
wherein each ring in the system contains three to twelve ring
members. The term "aryl" may be used interchangeably with the term
"aryl ring". In certain embodiments of the present invention,
"aryl" refers to an aromatic ring system which includes, but is not
limited to, phenyl, biphenyl, naphthyl, anthracyl and the like,
which may bear one or more substituents. Also included within the
scope of the term "aryl", as it is used herein, is a group in which
an aromatic ring is fused to one or more additional rings, such as
benzofuranyl, indanyl, phthalimidyl, naphthimidyl, phenantriidinyl,
or tetrahydronaphthyl, and the like. In certain embodiments, the
terms "6- to 10-membered aryl" and "C.sub.6-10 aryl" refer to a
phenyl or an 8- to 10-membered polycyclic aryl ring. In certain
embodiments, the term "6- to 12-membered aryl" refers to a phenyl
or an 8- to 12-membered polycyclic aryl ring. In certain
embodiments, the term "C.sub.6-14 aryl" refers to a phenyl or an 8-
to 14-membered polycyclic aryl ring.
[0052] The terms "heteroaryl" and "heteroar-", used alone or as
part of a larger moiety, e.g., "heteroaralkyl", or
"heteroaralkoxy", refer to groups having 5 to 14 ring atoms,
preferably 5, 6, or 9 ring atoms; having 6, 10, or 14 .pi.
electrons shared in a cyclic array; and having, in addition to
carbon atoms, from one to five heteroatoms. The term "heteroatom"
refers to nitrogen, oxygen, or sulfur, and includes any oxidized
form of nitrogen or sulfur, and any quaternized form of a basic
nitrogen. Heteroaryl groups include, without limitation, thienyl,
furanyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl,
oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl,
thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl,
indolizinyl, purinyl, naphthyridinyl, benzofuranyl and pteridinyl.
The terms "heteroaryl" and "heteroar-", as used herein, also
include groups in which a heteroaromatic ring is fused to one or
more aryl, cycloaliphatic, or heterocyclyl rings, where the radical
or point of attachment is on the heteroaromatic ring. Nonlimiting
examples include indolyl, isoindolyl, benzothienyl, benzofuranyl,
dibenzofuranyl, indazolyl, benzimidazolyl, benzthiazolyl, quinolyl,
isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl,
4H-quinolizinyl, carbazolyl, acridinyl, phenazinyl, phenothiazinyl,
phenoxazinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, and
pyrido[2,3-b]-1,4-oxazin-3(4H)-one. A heteroaryl group may be mono-
or bicyclic. The term "heteroaryl" may be used interchangeably with
the terms "heteroaryl ring", "heteroaryl group", or
"heteroaromatic", any of which terms include rings that are
optionally substituted. The term "heteroaralkyl" refers to an alkyl
group substituted by a heteroaryl, wherein the alkyl and heteroaryl
portions independently are optionally substituted. In certain
embodiments, the term "5- to 10-membered heteroaryl" refers to a 5-
to 6-membered heteroaryl ring having 1 to 3 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an 8-
to 10-membered bicyclic heteroaryl ring having 1 to 4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur. In certain
embodiments, the term "5- to 12-membered heteroaryl" refers to a 5-
to 6-membered heteroaryl ring having 1 to 3 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an 8-
to 12-membered bicyclic heteroaryl ring having 1 to 4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur.
[0053] As used herein, the terms "heterocycle", "heterocyclyl",
"heterocyclic radical", and "heterocyclic ring" are used
interchangeably and refer to a stable 5- to 7-membered monocyclic
or 7- to 14-membered bicyclic heterocyclic moiety that is either
saturated or partially unsaturated, and having, in addition to
carbon atoms, one or more, preferably one to four, heteroatoms, as
defined above. When used in reference to a ring atom of a
heterocycle, the term "nitrogen" includes a substituted nitrogen.
As an example, in a saturated or partially unsaturated ring having
0-3 heteroatoms selected from oxygen, sulfur or nitrogen, the
nitrogen may be N (as in 3,4-dihydro-2H-pyrrolyl), NH (as in
pyrrolidinyl), or .sup.+NR (as in N-substituted pyrrolidinyl). In
some embodiments, the term "3- to 7-membered heterocyclic" refers
to a 3- to 7-membered saturated or partially unsaturated monocyclic
heterocyclic ring having 1 to 2 heteroatoms independently selected
from nitrogen, oxygen, or sulfur. In some embodiments, the term "3-
to 8-membered heterocycle" refers to a 3- to 8-membered saturated
or partially unsaturated monocyclic heterocyclic ring having 1 to 2
heteroatoms independently selected from nitrogen, oxygen, or
sulfur. In some embodiments, the term "3- to 12-membered
heterocyclic" refers to a 3- to 8-membered saturated or partially
unsaturated monocyclic heterocyclic ring having 1 to 2 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or a 7- to
12-membered saturated or partially unsaturated polycyclic
heterocyclic ring having 1-3 heteroatoms independently selected
from nitrogen, oxygen, or sulfur. In some embodiments, the term "3-
to 14-membered heterocycle" refers to a 3- to 8-membered saturated
or partially unsaturated monocyclic heterocyclic ring having 1 to 2
heteroatoms independently selected from nitrogen, oxygen, or
sulfur, or a 7- to 14-membered saturated or partially unsaturated
polycyclic heterocyclic ring having 1-3 heteroatoms independently
selected from nitrogen, oxygen, or sulfur.
[0054] A heterocyclic ring can be attached to its pendant group at
any heteroatom or carbon atom that results in a stable structure
and any of the ring atoms can be optionally substituted. Examples
of such saturated or partially unsaturated heterocyclic radicals
include, without limitation, tetrahydrofuranyl, tetrahydrothienyl,
pyrrolidinyl, pyrrolidonyl, piperidinyl, pyrrolinyl,
tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl,
oxazolidinyl, piperazinyl, dioxanyl, dioxolanyl, diazepinyl,
oxazepinyl, thiazepinyl, morpholinyl, and quinuclidinyl. The terms
"heterocycle", "heterocyclyl", "heterocyclyl ring", "heterocyclic
group", "heterocyclic moiety", and "heterocyclic radical", are used
interchangeably herein, and also include groups in which a
heterocyclyl ring is fused to one or more aryl, heteroaryl, or
cycloaliphatic rings, such as indolinyl, 3H-indolyl, chromanyl,
phenanthridinyl, or tetrahydroquinolinyl, where the radical or
point of attachment is on the heterocyclyl ring. A heterocyclyl
group may be mono- or bicyclic. The term "heterocyclylalkyl" refers
to an alkyl group substituted by a heterocyclyl, wherein the alkyl
and heterocyclyl portions independently are optionally
substituted.
[0055] As used herein, the term "partially unsaturated" refers to a
ring moiety that includes at least one double or triple bond. The
term "partially unsaturated" is intended to encompass rings having
multiple sites of unsaturation, but is not intended to include aryl
or heteroaryl moieties, as herein defined.
[0056] One of ordinary skill in the art will appreciate that the
synthetic methods, as described herein, may utilize a variety of
protecting groups. By the term "protecting group," as used herein,
it is meant that a particular functional moiety, e.g., O, S, or N,
is masked or blocked, permitting, if desired, a reaction to be
carried out selectively at another reactive site in a
multifunctional compound. In some embodiments, a protecting group
reacts selectively in good yield to give a protected substrate that
is stable to the projected reactions; the protecting group is
preferably selectively removable by readily available, preferably
non-toxic reagents that do not attack the other functional groups;
the protecting group forms a separable derivative (more preferably
without the generation of new stereogenic centers); and the
protecting group will preferably have a minimum of additional
functionality to avoid further sites of reaction. By way of
non-limiting example, hydroxyl protecting groups include methyl,
methoxylmethyl (MOM), methylthiomethyl (MTM), t-butylthiomethyl,
(phenyldimethylsilyl)methoxymethyl (SMOM), benzyloxymethyl (BOM),
p-methoxybenzyloxymethyl (PMBM), (4-methoxyphenoxy)methyl (p-AOM),
guaiacolmethyl (GUM), t-butoxymethyl, 4-pentenyloxymethyl (POM),
siloxymethyl, 2-methoxyethoxymethyl (MEM),
2,2,2-trichloroethoxymethyl, bis(2-chloroethoxy)methyl,
2-(trimethylsilyl)ethoxymethyl (SEMOR), tetrahydropyranyl (THP),
3-bromotetrahydropyranyl, tetrahydrothiopyranyl,
1-methoxycyclohexyl, 4-methoxytetrahydropyranyl (MTHP),
4-methoxytetrahydrothiopyranyl, 4-methoxytetrahydrothiopyranyl
S,S-dioxide, 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl
(CTMP), 1,4-dioxan-2-yl, tetrahydrofuranyl, tetrahydrothiofuranyl,
2,3,3a,4,5,6,7,7
a-octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl,
1-ethoxyethyl, 1-(2-chloroethoxy)ethyl, 1-methyl-1-methoxyethyl,
1-methyl-1-benzyloxyethyl, 1-methyl-1-benzyloxy-2-fluoro ethyl,
2,2,2-trichloroethyl, 2-trimethylsilylethyl,
2-(phenylselenyl)ethyl, t-butyl, allyl, p-chlorophenyl,
p-methoxyphenyl, 2,4-dinitrophenyl, benzyl, p-methoxybenzyl,
3,4-dimethoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-halobenzyl,
2,6-dichlorobenzyl, p-cyanobenzyl, p-phenylbenzyl, 2-picolyl,
4-picolyl, 3-methyl-2-picolyl N-oxido, diphenylmethyl,
p,p'-dinitrobenzhydryl, 5-dibenzosuberyl, triphenylmethyl,
.alpha.-naphthyldiphenylmethyl, p-methoxyphenyldiphenylmethyl,
di(p-methoxyphenyl)phenylmethyl, tri(p-methoxyphenyl)methyl,
4-(4'-bromophenacyloxyphenyl)diphenylmethyl,
4,4',4''-tris(4,5-dichlorophthalimidophenyl)methyl,
4,4',4''-tris(levulinoyloxyphenyl)methyl,
4,4',4''-tris(benzoyloxyphenyl)methyl,
3-(imidazol-1-yl)bis(4',4''-dimethoxyphenyl)methyl,
1,1-bis(4-methoxyphenyl)-1'-pyrenylmethyl, 9-anthryl,
9-(9-phenyl)xanthenyl, 9-(9-phenyl-10-oxo)anthryl,
1,3-benzodithiolan-2-yl, benzisothiazolyl S,S-dioxido ,
trimethylsilyl (TMS), triethylsilyl (TES), triisopropylsilyl
(TIPS), dimethylisopropylsilyl (IPDMS), diethylisopropylsilyl
(DEIPS), dimethylthexylsilyl, t-butyldimethylsilyl (TBDMS),
t-butyldiphenylsilyl (TBDPS), tribenzylsilyl, tri-p-xylylsilyl,
triphenylsilyl, diphenylmethylsilyl (DPMS),
t-butylmethoxyphenylsilyl (TBMPS), formate, benzoylformate,
acetate, chloroacetate, dichloroacetate, trichloroacetate,
trifluoroacetate, methoxyacetate, triphenylmethoxyacetate,
phenoxyacetate, p-chlorophenoxyacetate, 3-phenylpropionate ,
4-oxopentanoate (levulinate), 4,4-(ethylenedithio)pentanoate
(levulinoyldithioacetal), pivaloate, adamantoate, crotonate,
4-methoxycrotonate, benzoate, p-phenylbenzoate,
2,4,6-trimethylbenzoate (mesitoate), alkyl methyl carbonate,
9-fluorenylmethyl carbonate (Fmoc), alkyl ethyl carbonate, alkyl
2,2,2-trichloroethyl carbonate (Troc), 2-(trimethylsilyl)ethyl
carbonate (TMSEC), 2-(phenylsulfonyl) ethyl carbonate (Psec),
2-(triphenylphosphonio) ethyl carbonate (Peoc), alkyl isobutyl
carbonate, alkyl vinyl carbonate alkyl allyl carbonate, alkyl
p-nitrophenyl carbonate, alkyl benzyl carbonate, alkyl
p-methoxybenzyl carbonate, alkyl 3,4-dimethoxybenzyl carbonate,
alkyl o-nitrobenzyl carbonate, alkyl p-nitrobenzyl carbonate, alkyl
S-benzyl thiocarbonate, 4-ethoxy-1-napththyl carbonate, methyl
dithiocarbonate, 2-iodobenzoate, 4-azidobutyrate,
4-nitro-4-methylpentanoate, o-(dibromomethyl)benzoate,
2-formylbenzenesulfonate, 2-(methylthiomethoxy)ethyl,
4-(methylthiomethoxy)butyrate, 2-(methylthiomethoxymethyl)benzoate,
2,6-dichloro-4-methylphenoxyacetate,
2,6-dichloro-4-(1,1,3,3-tetramethylbutyl)phenoxyacetate,
2,4-bis(1,1-dimethylpropyl)phenoxyacetate, chlorodiphenylacetate,
isobutyrate, monosuccinoate, (E)-2-methyl-2-butenoate,
o-(methoxycarbonyl)benzoate, .alpha.-naphthoate, nitrate, alkyl
N,N,N',N'-tetramethylphosphorodiamidate, alkyl N-phenylcarbamate,
borate, dimethylphosphinothioyl, alkyl 2,4-dinitrophenylsulfenate,
sulfate, methanesulfonate (mesylate), benzylsulfonate, and tosylate
(Ts). Exemplary protecting groups are detailed herein, however, it
will be appreciated that the present disclosure is not intended to
be limited to these protecting groups; rather, a variety of
additional equivalent protecting groups can be readily identified
using the above criteria and utilized in the method of the present
disclosure. Additionally, a variety of protecting groups are
described by Greene and Wuts (infra).
[0057] As described herein, compounds of the invention may contain
"optionally substituted" moieties. In general, the term
"substituted", whether preceded by the term "optionally" or not,
means that one or more hydrogens of the designated moiety are
replaced with a suitable substituent. Unless otherwise indicated,
an "optionally substituted" group may have a suitable substituent
at each substitutable position of the group, and when more than one
position in any given structure may be substituted with more than
one substituent selected from a specified group, the substituent
may be either the same or different at every position. Combinations
of substituents envisioned by this invention are preferably those
that result in the formation of stable or chemically feasible
compounds. The term "stable", as used herein, refers to compounds
that are not substantially altered when subjected to conditions to
allow for their production, detection, and, in certain embodiments,
their recovery, purification, and use for one or more of the
purposes disclosed herein.
[0058] Suitable monovalent substituents on a substitutable carbon
atom of an "optionally substituted" group are independently
halogen; --(CH.sub.2).sub.0-4R.sup.o; --(CH.sub.2).sub.0-4OR.sup.o;
--O--(CH.sub.2).sub.0-4C(O)OR.sup.o;)
--(CH.sub.2).sub.0-4CH(OR.sup.o).sub.2;
--(CH.sub.2).sub.0-4SR.sup.o; --(CH.sub.2).sub.0-4Ph, which may be
substituted with R.sup.o; --(CH.sub.2).sub.0-4O(CH.sub.2).sub.0-1Ph
which may be substituted with R.sup.o; --CH.dbd.CHPh, which may be
substituted with R.sup.o; --NO.sub.2; --CN; --N.sub.3;
--(CH.sub.2).sub.0-4N(R.sup.o).sub.2;
--(CH.sub.2).sub.0-4N(R.sup.o)C(O)R.sup.o; --N(R.sup.o)C(S)R.sup.o;
--(CH.sub.2).sub.0-4N(R.sup.o)C(O)NR.sup.o.sub.2;
--N(R.sup.o)C(S)NR.sup.o.sub.2;
--(CH.sub.2).sub.0-4N(R.sup.o)C(O)OR.sup.o;
--N(R.sup.o)N(R.sup.o)C(O)R.sup.o;
--N(R.sup.o)N(R.sup.o)C(O)NR.sup.o.sub.2;
--N(R.sup.o)N(R.sup.o)C(O)OR.sup.o;
--(CH.sub.2).sub.0-4C(O)R.sup.o; --C(S)R.sup.o;
--(CH.sub.2).sub.0-4C(O)OR.sup.o;
--(CH.sub.2).sub.0-4C(O)N(R.sup.o).sub.2;
--(CH.sub.2).sub.0-4C(O)SR.sup.o;
--(CH.sub.2).sub.0-4C(O)OSiR.sup.o.sub.3;
--(CH.sub.2).sub.0-4OC(O)R.sup.o; --OC(O)(CH.sub.2).sub.0-4SR--,
SC(S)SR.sup.o; --(CH.sub.2).sub.0-4SC(O)R.sup.o;
--(CH.sub.2).sub.0-4C(O)NR.sup.o.sub.2; --C(S)NR.sup.o.sub.2;
--C(S)SR.sup.o; --SC(S)SR.sup.o,
--(CH.sub.2).sub.0-4OC(O)NR.sup.o.sub.2; --C(O)N(OR.sup.o)R.sup.o;
--C(O)C(O)R.sup.o; --C(O)CH.sub.2C(O)R.sup.o;
--C(NOR.sup.o)R.sup.o; --(CH.sub.2).sub.0-4SSR.sup.o;
--(CH.sub.2).sub.0-4S(O).sub.2R.sup.o;
--(CH.sub.2).sub.0-4S(O).sub.2OR.sup.o;
--(CH.sub.2).sub.0-4OS(O).sub.2R.sup.o; --S(O).sub.2NR.sup.o.sub.2;
--(CH.sub.2).sub.0-4S(O)R.sup.o;
--N(R.sup.o)S(O).sub.2NR.sup.o.sub.2;
--N(R.sup.o)S(O).sub.2R.sup.o; --N(OR.sup.o)R.sup.o;
--C(NH)NR.sup.o.sub.2; --P(O).sub.2R.sup.o; --P(O)R.sup.o.sub.2;
--OP(O)R.sup.o.sub.2; --OP(O)(OR.sup.o).sub.2; SiR.sup.o.sub.3;
--(C.sub.1-4 straight or branched)alkylene)O--N(R.sup.o).sub.2; or
--(C.sub.1-4 straight or branched)alkylene)C(O)O--N(R.sup.o).sub.2,
wherein each R.sup.o may be substituted as defined below and is
independently hydrogen, C.sub.1-8 aliphatic, --CH.sub.2Ph,
--O(CH.sub.2).sub.0-1Ph, or a 5-6-membered saturated, partially
unsaturated, or aryl ring having 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur, or, notwithstanding the
definition above, two independent occurrences of R.sup.o, taken
together with their intervening atom(s), form a 3- to 12-membered
saturated, partially unsaturated, or aryl mono- or polycyclic ring
having 0-4 heteroatoms independently selected from nitrogen,
oxygen, or sulfur, which may be substituted as defined below.
[0059] Suitable monovalent substituents on R.sup.o (or the ring
formed by taking two independent occurrences of R.sup.o together
with their intervening atoms), are independently halogen,
--(CH.sub.2).sub.0-2R.sup. , --(haloR.sup. ),
--(CH.sub.2).sub.0-2OH, --(CH.sub.2).sub.0-2OR.sup. ,
--(CH.sub.2).sub.0-2CH(OR.sup. ).sub.2; --O(haloR.sup. ), --CN,
--N.sub.3, --(CH.sub.2).sub.0-2C(O)R.sup. ,
--(CH.sub.2).sub.0-2C(O)OH, --(CH.sub.2).sub.0-2C(O)OR.sup. ,
--(CH.sub.2).sub.0-4C(O)N(R.sup.o.sub.2;
--(CH.sub.2).sub.0-2SR.sup. , --(CH.sub.2).sub.0-2SH,
--(CH.sub.2).sub.0-2NH.sub.2, --(CH.sub.2).sub.0-2NHR.sup.574 ,
--(CH.sub.2).sub.0-2NR.sup. .sub.2, --NO.sub.2, --SiR.sup. .sub.3,
--OSiR.sup. .sub.3, --C(O)SR.sup. , --(C.sub.1-4 straight or
branched alkylene)C(O)OR.sup. , or --SSR.sup. wherein each R.sup.
is unsubstituted or where preceded by "halo" is substituted only
with one or more halogens, and is independently selected from
C.sub.1-4 aliphatic, --CH.sub.2Ph, --O(CH.sub.2).sub.0-1Ph, or a 5-
to 6-membered saturated, partially unsaturated, or aryl ring having
0-4 heteroatoms independently selected from nitrogen, oxygen, or
sulfur. Suitable divalent substituents on a saturated carbon atom
of R.sup.o include .dbd.O and .dbd.S.
[0060] Suitable divalent substituents on a saturated carbon atom of
an "optionally substituted" group include the following: .dbd.O,
.dbd.S, .dbd.NNR*.sub.2, .dbd.NNHC(O)R*, .dbd.NNHC(O)OR*,
.dbd.NNHS(O).sub.2R*, .dbd.NR*, .dbd.NOR*,
--O(C(R*.sub.2)).sub.2-3O--, or --S(C(R*.sub.2)).sub.2-3S--,
wherein each independent occurrence of R* is selected from
hydrogen, C.sub.1-6 aliphatic which may be substituted as defined
below, or an unsubstituted 5-6-membered saturated, partially
unsaturated, or aryl ring having 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur. Suitable divalent
substituents that are bound to vicinal substitutable carbons of an
"optionally substituted" group include: --O(CR*.sub.2).sub.2-3O--,
wherein each independent occurrence of R* is selected from
hydrogen, C.sub.1-6 aliphatic which may be substituted as defined
below, or an unsubstituted 5- to 6-membered saturated, partially
unsaturated, or aryl ring having 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur.
[0061] Suitable substituents on the aliphatic group of R* include
halogen, --R.sup. , --(haloR.sup. ), --OH, --OR.sup. ,
--O(haloR.sup. ), --CN, --C(O)OH, --C(O)OR.sup. , --NH.sub.2,
--NHR.sup. , --NR.sup. .sub.2, or --NO.sub.2, wherein each R.sup.
is unsubstituted or where preceded by "halo" is substituted only
with one or more halogens, and is independently C.sub.1-4
aliphatic, --CH.sub.2Ph, --O(CH.sub.2).sub.0-1Ph, or a 5- to
6-membered saturated, partially unsaturated, or aryl ring having
0-4 heteroatoms independently selected from nitrogen, oxygen, or
sulfur.
[0062] Suitable substituents on a substitutable nitrogen of an
"optionally substituted" group include --R.sup..dagger.,
--NR.sup..dagger..sub.2, --C(O)R.sup..dagger.,
--C(O)OR.sup..dagger., --C(O)C(O)R.sup..dagger.,
--C(O)CH.sub.2C(O)R.sup..dagger., --S(O).sub.2R.sup..dagger.,
--S(O).sub.2NR.sup..dagger..sub.2, --C(S)NR.sup..dagger..sub.2,
--C(NH)NR.sup..dagger..sub.2, or
--N(R.sup..dagger.)S(O).sub.2R.sup..dagger.; wherein each
R.sup..dagger. is independently hydrogen, C.sub.1-6 aliphatic which
may be substituted as defined below, unsubstituted --OPh, or an
unsubstituted 5- to 6-membered saturated, partially unsaturated, or
aryl ring having 0-4 heteroatoms independently selected from
nitrogen, oxygen, or sulfur, or, notwithstanding the definition
above, two independent occurrences of R.sup..dagger., taken
together with their intervening atom(s) form an unsubstituted 3- to
12-membered saturated, partially unsaturated, or aryl mono- or
bicyclic ring having 0-4 heteroatoms independently selected from
nitrogen, oxygen, or sulfur.
[0063] Suitable substituents on the aliphatic group of
R.sup..dagger. are independently halogen, --R.sup. , --(haloR.sup.
), --OH, --OR.sup. , --O(haloR.sup. ), --CN, --C(O)OH,
--C(O)OR.sup. , --NH.sub.2, --NHR.sup. , --NR.sup. .sub.2, or
--NO.sub.2, wherein each R.sup. is unsubstituted or where preceded
by "halo" is substituted only with one or more halogens, and is
independently C.sub.1-4 aliphatic, --CH.sub.2Ph,
--O(CH.sub.2).sub.0-1Ph, or a 5- to 6-membered saturated, partially
unsaturated, or aryl ring having 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur.
[0064] By `carbonylation`, we refer to reactions that add carbon
monoxide to an organic compound, thus increasing the organic
substrate molecule by one carbon atom. Furthermore, the resulting
compounds contain the C.dbd.O carbonyl functional group.
DETAILED DESCRIPTION OF CERTAIN EMBODIMENTS
[0065] In one aspect, the present invention encompasses integrated
processes and methods for the conversion of epoxides to acrylic
acid derivatives and polyesters. In another aspect, the invention
provides systems suitable for effecting the conversion of epoxides
to acrylic acid derivatives and polyesters.
I. Methods of the Invention
[0066] In certain embodiments, the present invention encompasses
methods for the conversion of epoxides to acrylates and related
products. In certain embodiments, the methods comprise the steps
of: [0067] i) providing a feedstock stream comprising an epoxide
and carbon monoxide; [0068] ii) contacting the feedstock stream
with a metal carbonyl in a first reaction zone to effect conversion
of at least a portion of the provided epoxide to a beta lactone;
[0069] iii) directing the effluent from the first reaction zone to
a second reaction zone where the beta lactone is subjected to
conditions that convert it to a compound selected from the group
consisting of: an alpha beta unsaturated acid, an alpha beta
unsaturated ester, an alpha beta unsaturated amide, and an
optionally substituted polypropiolactone polymer; and [0070] iv)
isolating a final product comprising the alpha-beta unsaturated
carboxylic acid, the alpha-beta unsaturated ester, the alpha-beta
unsaturated amide or the polypropiolactone,
[0071] where the composition of the feedstock stream, the identity
of the metal carbonyl the composition of the effluent from the
first reaction zone, the identity of the conditions in the second
reaction zone and the manner of isolation are as defined
hereinbelow and in the classes and subclasses herein.
[0072] The sections below describe more fully each step of the
method and the conditions utilized to effect each step.
[0073] Ia) The Feedstock Stream
[0074] The first reaction stage (i.e. the stage fed by the epoxide
feedstock stream) is also referred to herein as the carbonylation
stage. The purpose of this stage is to convert the epoxide fed into
the stage into a beta lactone by carbonylation.
[0075] As noted above, the feedstock stream contains an epoxide and
carbon monoxide. In certain embodiments, the feedstock stream
comprises a C.sub.2-20 aliphatic or aromatic epoxide. In certain
embodiments, the feedstock stream comprises a C.sub.2-12 aliphatic
epoxide. In certain embodiments, the feedstock stream comprises an
epoxide selected from the group consisting of: ethylene oxide,
propylene oxide, 1-butylene oxide, 2-butylene oxide, 1-hexene
oxide, 1-octene oxide, epichlorohydrin, and mixtures of two or more
of these. In certain embodiments, the feedstock stream comprises
ethylene oxide. In certain embodiments, the feedstock stream
comprises propylene oxide.
[0076] In certain embodiments, the feedstock stream comprises a
gaseous mixture containing epoxide and carbon monoxide. In certain
embodiments, the molar ratio of carbon monoxide to epoxide in
feedstock stream ranges from about 1:1 to about 10,000:1. In
certain embodiments, the molar ratio of carbon monoxide to epoxide
in feedstock stream is about 5000:1, is about 2500:1, is about
2000:1, is about 1500:1, is about 1000:1, is about 500:1, is about
1:500, is about 200:1, is about 100:1, is about 50:1, is about
20:1, is about 10:1, is about 5:1 or is about 1:1. In some
embodiments, the ratio of carbon monoxide to epoxide is selected,
based on other reaction conditions, so that the reaction proceeds
in an economical and time-feasible manner. In some embodiments, the
ratio of carbon monoxide to epoxide in the feedstock stream is
between about 1:1 to about 100:1. In some embodiments, the ratio of
carbon monoxide to epoxide in the feedstock stream is between about
1:1 to about 1000:1. In some embodiments, the ratio of carbon
monoxide to epoxide in the feedstock stream is between about 10:1
to about 1000:1. In some embodiments, the ratio of carbon monoxide
to epoxide in the feedstock stream is between about 10:1 to about
10,000:1. In some embodiments, the ratio of carbon monoxide to
epoxide in the feedstock stream is between about 100:1 to about
1000:1. In some embodiments, the ratio of carbon monoxide to
epoxide in the feedstock stream is between about 10:1 to about
1000:1. In some embodiments, the ratio of carbon monoxide to
epoxide in the feedstock stream is between about 10:1 to about
500:1. In some embodiments, the ratio of carbon monoxide to epoxide
in the feedstock stream is between about 10:1 to about 100:1. In
some embodiments, the ratio of carbon monoxide to epoxide in the
feedstock stream is between about 10:1 to about 50:1. In some
embodiments, the ratio of carbon monoxide to epoxide in the
feedstock stream is between about 20:1 to about 200:1. In some
embodiments, the ratio of carbon monoxide to epoxide in the
feedstock stream is between about 50:1 to about 200:1.
[0077] In certain embodiments, the gaseous feedstock stream
comprises ethylene oxide (EO) and carbon monoxide (CO). In certain
embodiments, the gaseous EO/CO stream is provided at a temperature,
pressure, and EO:CO gas ratio such that the mixture is above the
dew point of ethylene oxide. In certain embodiments, the gaseous
EO/CO mixture comprises a greater partial pressure of carbon
monoxide than ethylene oxide. In certain embodiments, the EO/CO
gaseous feedstock stream is heated to maintain a temperature and
pressure at which the ethylene oxide remains in the gas phase.
Determining compositions, temperatures and pressures at which the
EO/CO feedstock stream remains gaseous is within the capability of
the skilled artisan, these mixtures can be determined
experimentally, or by reference to the phase diagram of ethylene
oxide.
[0078] In certain embodiments, the feedstock stream further
comprises one or more additional components. In certain
embodiments, the additional components comprise diluents which do
not directly participate in the chemical reactions of the epoxide
or its derivatives. In certain embodiments, such diluents may
include one or more inert gases (e.g. nitrogen, argon, helium and
the like) or volatile organic molecules such as hydrocarbons,
ethers, and the like. In certain embodiments, the feed stream may
comprise hydrogen, traces of carbon dioxide, methane, and other
compounds commonly found in industrial carbon monoxide streams. In
certain embodiments, the feed stream may further comprise materials
that may have a direct or indirect chemical function in one or more
of the processes involved in the conversion of the epoxide to
various end products. In certain embodiments, such functional
materials may include, but are not limited to: volatile metal
carbonyl compounds (e.g. HCo(CO).sub.4) and the like), protic
compounds (e.g. water or alcohols), and stabilizers (e.g. amine
bases, phosphorous compounds and the like).
[0079] Additional reactants can include mixtures of carbon monoxide
and another gas. In some embodiments, carbon monoxide is provided
in a mixture with hydrogen (e.g., Syngas). The ratio of carbon
monoxide and hydrogen can be any ratio, including by not limited to
1:1, 1:2, 1:4, 1:10, 10:1, 4:1, or 2:1. The carbon monoxide sources
include but are not limited to: wood gas, producer gas, coal gas,
town gas, manufactured gas, hygas, Dowson gas or water gas, among
others. In some embodiments, the carbon monoxide is provided at
super-atmospheric pressure. The quantity of carbon monoxide should
be supplied to effect efficient conversion of the epoxide starting
material to a beta-lactone.
[0080] In certain embodiments, the feedstock stream is
characterized in that it is essentially free of oxygen. In certain
embodiments, the feedstock stream is characterized in that it is
essentially free of water. In certain embodiments, the feedstock
stream is characterized in that it is essentially free of oxygen
and water.
[0081] In certain embodiments, the feedstock stream provided in
step i) of the above-described process comprises ethylene oxide. In
certain embodiments, the ethylene oxide in the feedstock stream is
obtained directly from the gas phase oxidation of ethylene. This
embodiment is advantageous in that it avoids the need to isolate,
store, and transport ethylene oxide which is both toxic and
explosive. In certain embodiments, the ethylene oxide is maintained
in the gas phase as produced and fed to the carbonylation stage
without condensing it to a liquid. Thus, in certain embodiments,
the present invention encompasses methods for the conversion of
ethylene gas to acrylic acid or its derivatives, the process
comprising the steps of: [0082] feeding ethylene to an oxidation
stage to produce a reaction stream comprising ethylene oxide
(preferably using known commercial processes such as oxidation by
O.sub.2 in the presence of silver); [0083] contacting the ethylene
oxide-containing stream with carbon monoxide in the presence of a
metal carbonyl compound in a second stage to provide a product
stream comprising beta propiolactone; and [0084] directing the beta
propiolactone-containing product stream to a conversion stage where
it is subjected to conditions to convert it to a final product
selected from the group consisting of: acrylic acid, an acrylate
ester, an acrylamide, and polypropiolactone.
[0085] In certain embodiments, the ethylene oxide feedstock stream
is first treated to remove water. In certain embodiments, the
ethylene oxide feedstock stream is first treated to remove carbon
dioxide. In certain embodiments, the method includes a step of
adding carbon monoxide to the ethylene oxide stream. In certain
embodiments, this addition of carbon monoxide is done before the
ethylene oxide stream enters the carbonylation stage.
[0086] Ib) Catalysts
[0087] As noted above, the first reaction stage comprises at least
one metal carbonyl compound. Typically, a single metal carbonyl
compound is provided, but in certain embodiments, mixtures of two
or more metal carbonyl compounds are provided. Preferably, the
provided metal carbonyl compound is capable of ring-opening an
epoxide and facilitating the insertion of carbon monoxide into the
resulting metal carbon bond. Metal carbonyl compounds with this
reactivity are well known in the art and are used for laboratory
experimentation as well as in industrial processes such as
hydroformylation.
[0088] In some embodiments, a metal carbonyl compound in the
carbonylation stage of the process comprises a compound with the
general formula [QM.sub.y(CO).sub.w].sup.x, where: [0089] Q is any
ligand or more than one ligand and need not be present; [0090] M is
a metal atom; [0091] y is an integer from 1 to 6 inclusive; [0092]
w is a number such as to provide the stable metal carbonyl; and
[0093] x is an integer from -3 to +3 inclusive.
[0094] In certain embodiments where a metal carbonyl compound has
the formula [QM.sub.y(CO).sub.w].sup.x, M is selected from the
group consisting of Ti, Cr, Mn, Fe, Ru, Co, Rh, Ni, Pd, Cu, Zn, Al,
Ga and In. In certain embodiments, M is Co.
[0095] In certain embodiments, metal carbonyl compound in the
carbonylation stage comprises a Group 9 metal carbonyl. In certain
embodiments, the Group 9 metal carbonyl compound is selected from
the group consisting of Co.sub.2(CO).sub.8, Co.sub.4(CO).sub.12,
Rh.sub.4(CO).sub.16, Ir.sub.4(CO).sub.12 and mixtures of two or
more of these. In certain embodiments, the metal carbonyl comprises
a cobalt compound. In certain embodiments, the Group 9 metal
carbonyl compound comprises the moiety Co(CO).sub.4.sup.-.
[0096] In certain embodiments, a provided metal carbonyl compound
comprises an anionic metal carbonyl moiety (i.e. x is a negative
integer). In other embodiments, a provided metal carbonyl compound
comprises a neutral metal carbonyl compound (i.e. x is zero). In
certain embodiments, a provided metal carbonyl compound comprises a
metal carbonyl hydride. In some embodiments, a provided metal
carbonyl compound acts as a pre-catalyst which reacts in situ with
one or more reaction components, additives, or solid supports, to
provide an active species different from the compound initially
provided. Such pre-catalysts are specifically encompassed by the
present invention as is the recognition that the active species in
a given reaction may not be known with certainty, thus the
identification of such a reactive species in situ, does not itself
depart from the spirit or teachings of the present invention.
[0097] In certain embodiments where the metal carbonyl compound
comprises an anionic metal carbonyl species, the metal carbonyl
species has the general formula [QM.sub.y(CO).sub.w*].sup.z-, where
Q, M, and y are as defined above and in the classes and subclasses
described herein, w* is an integer such as to provide a stable
anionic metal carbonyl, and z is an integer from 1 to 3.
[0098] In certain embodiments, the anionic metal carbonyl species
include monoanionic carbonyl complexes of metals from groups 5, 7
or 9 of the periodic table or dianionic carbonyl complexes of
metals from groups 4 or 8 of the periodic table. In some
embodiments, the anionic metal carbonyl compound contains cobalt or
manganese. In some embodiments, the anionic metal carbonyl compound
contains rhodium. Suitable anionic metal carbonyl compounds
include, but are not limited to: [Co(CO).sub.4].sup.-,
[Ti(CO).sub.6].sup.2-, [V(CO).sub.6].sup.-, [Rh(CO).sub.4].sup.-,
[Fe(CO).sub.4].sup.2-, [Ru(CO).sub.4].sup.2-,
[OS(CO).sub.4].sup.2-, [Cr.sub.2(CO).sub.10].sup.2-,
[Fe.sub.2(CO).sub.8].sup.2-, [Tc(CO).sub.5].sup.-,
[Re(CO).sub.5].sup.-, and [Mn(CO).sub.5].sup.-. In certain
embodiments, the anionic metal carbonyl comprises
[Co(CO).sub.4].sup.-. In some embodiments, a mixture of two or more
anionic metal carbonyl complexes may be present in the
carbonylation stage.
[0099] The term "such as to provide a stable anionic metal
carbonyl" for [QM.sub.y(CO).sub.w*].sup.z- is used herein to mean
that [QM.sub.y(CO).sub.w*].sup.z- is a species characterizable by
analytical means, e.g., NMR, IR, X-ray crystallography, Raman
spectroscopy and/or electron spin resonance (EPR) or is isolable in
catalyst form in the presence of a suitable cation or a species
formed in situ. It is to be understood that metals which can form
stable metal carbonyl complexes have known coordinative capacities
and propensities to form polynuclear complexes which, together with
the number and character of optional ligands Q that may be present
and the charge on the complex will determine the number of sites
available for carbon monoxide to coordinate and therefore the value
of w*. Typically, such compounds conform to the "18-electron rule".
Such knowledge is within the grasp of one having ordinary skill in
the arts pertaining to the synthesis and characterization of metal
carbonyl compounds.
[0100] In embodiments where the provided metal carbonyl compound is
an anionic species, one or more cations must also necessarily be
present. The present invention places no particular constraints on
the identity of such cations. In certain embodiments, the cation
associated with an anionic metal carbonyl compound comprises a
simple metal cation such as those from Groups 1 or 2 of the
periodic table (e.g. Na.sup.+, Li.sup.+, K.sup.+, Mg.sup.2+ and the
like). In other embodiments a cation associated with a provided
anionic metal carbonyl compound is a transition metal or transition
metal complex. In other embodiments a cation associated with a
provided anionic metal carbonyl compound is an organic cation. In
certain embodiments a cation associated with a provided anionic
metal carbonyl compound is a bulky non electrophilic cation such as
an `onium salt` (e.g. Bu.sub.4N.sup.+, PPN.sup.+, Ph.sub.4P.sup.+
Ph.sub.4As.sup.+, and the like). In certain embodiments, a metal
carbonyl anion is associated with a protonated nitrogen compound.
In some embodiments, the cation associated with an anionic metal
carbonyl compound comprises or is associated with a solid present
in the carbonylation reaction zone. These solids may include
inorganic materials or polymeric materials such as those which are
described more fully below.
[0101] In certain embodiments, a provided metal carbonyl compound
comprises a neutral metal carbonyl. In certain embodiments, such
neutral metal carbonyl compounds have the general formula
QM.sub.y(CO).sub.w', where Q, M, and y are as defined above and in
the classes and subclasses described herein, and w' is an integer
such as to provide a stable neutral metal carbonyl. In certain
embodiments, the neutral metal carbonyl has the general formula QM
(CO).sub.w'. In certain embodiments, the neutral metal carbonyl has
the general formula M(CO).sub.w'. In certain embodiments, the
neutral metal carbonyl has the general formula QM.sub.2(CO).sub.w'.
In certain embodiments, the neutral metal carbonyl has the general
formula M.sub.2(CO).sub.w'. In certain embodiments, the neutral
metal carbonyl has the general formula M.sub.3(CO).sub.w'. In
certain embodiments, the neutral metal carbonyl has the general
formula M.sub.4(CO).sub.w'.
[0102] In certain embodiments, the neutral metal carbonyl is
selected from the group consisting of: Ti(CO).sub.7;
V.sub.2(CO).sub.12; Cr(CO).sub.6; Mo(CO).sub.6; W(CO).sub.6
Mn.sub.2(CO).sub.10, Tc.sub.2(CO).sub.10, and Re.sub.2(CO).sub.10
Fe(CO).sub.5, Ru(CO).sub.5 and Os(CO).sub.5Ru.sub.3(CO).sub.12, and
Os.sub.3(CO).sub.12Fe.sub.3(CO).sub.12 and
Fe.sub.2(CO).sub.9Co.sub.4(CO).sub.12, Rh.sub.4(CO).sub.12,
Rh.sub.6(CO).sub.16, Ir.sub.4(CO).sub.12, Co.sub.2(CO).sub.8, and
Ni(CO).sub.4.
[0103] In certain embodiments, one or more of the carbon monoxide
ligands of any of the metal carbonyl compounds described above is
replaced with a ligand Q. In certain embodiments, the ligand Q is
present and represents a phosphine ligand. In certain embodiments,
Q is present and represents a cyclopentadienyl (cp) ligand.
[0104] In certain embodiments, reaction systems and methods of the
present invention comprise metal carbonyl hydrides (alternately
referred to as hydrido metal carbonyl compounds). In certain
embodiments, such compounds are provided as the metal carbonyl
hydride. In other embodiments, the metal carbonyl hydride is
generated in situ by reaction with hydrogen gas, or with a protic
acid using methods known in the art (see for example Chem. Rev.,
1972, 72 (3), pp 231-281 DOI: 10.1021/cr60277a003, the entirety of
which is incorporated herein by reference).
[0105] In certain embodiments, the metal carbonyl hydride (either
as provided or generated in situ) comprises one or more of
HCo(CO).sub.4, HCoQ(CO).sub.3, HMn(CO).sub.5, HMn(CO).sub.4Q,
HW(CO).sub.3Q, HRe(CO).sub.5, HMo(CO).sub.3Q, HOs(CO).sub.2Q,
HMo(CO).sub.2Q.sub.2, HFe(CO.sub.2)Q, HW(CO).sub.2Q.sub.2,
HRuCOQ.sub.2, H.sub.2Fe(CO).sub.4 or H.sub.2Ru(CO).sub.4, where
each Q is independently as defined above and in the classes and
subclasses herein. In certain embodiments, the metal carbonyl
hydride (either as provided or generated in situ) comprises
HCo(CO).sub.4. In certain embodiments, the metal carbonyl hydride
(either as provided or generated in situ) comprises
HCo(CO).sub.3PR.sub.3, where each R is independently an optionally
substituted aryl group, an optionally substituted C.sub.1-.sub.20
aliphatic group, a C.sub.1-10 alkoxy group, and an optionally
substituted phenoxy group. In certain embodiments, the metal
carbonyl hydride (either as provided or generated in situ)
comprises HCo(CO).sub.3cp, where cp represents an optionally
substituted cyclopentadienyl ligand. In certain embodiments, the
metal carbonyl hydride (either as provided or generated in situ)
comprises HMn(CO).sub.5. In certain embodiments, the metal carbonyl
hydride (either as provided or generated in situ) comprises
H.sub.2Fe(CO).sub.4.
[0106] In certain embodiments, for any of the metal carbonyl
compounds described above, M' comprises a transition metal. In
certain embodiments, for any of the metal carbonyl compounds
described above, M is selected from Groups 5 (Ti) to 10 (Ni) of the
periodic table. In certain embodiments, M is a Group 9 metal. In
certain embodiments, M is Co. In certain embodiments, M is Rh. In
certain embodiments, M is Ir. In certain embodiments, M is Fe. In
certain embodiments, M is Mn.
[0107] In certain embodiments, one or more ligands Q is present in
a provided metal carbonyl compound. In certain embodiments, Q is a
phosphine ligand. In certain embodiments, Q is a triaryl phosphine.
In certain embodiments, Q is trialkyl phosphine. In certain
embodiments, Q is a phosphite ligand. In certain embodiments, Q is
an optionally substituted cyclopentadienyl ligand. In certain
embodiments, Q is cp. In certain embodiments, Q is cp*.
[0108] In certain embodiments, the reaction zone into which the
epoxide/carbon monoxide stream is fed comprises a solid metal
carbonyl compound. In certain embodiments, the reaction zone
comprises a solid-supported metal carbonyl compound. In certain
embodiments, the solid supported metal carbonyl compound comprises
a Group VIII metal carbonyl. In certain embodiments, the Group VIII
metal carbonyl compound is selected from the group consisting of
Co.sub.2(CO).sub.8, Co.sub.4(CO).sub.12, Rh.sub.4(CO).sub.16,
Ir.sub.4(CO).sub.12 and mixtures of two or more of these. In
certain embodiments, the solid supported metal carbonyl comprises a
cobalt compound. In certain embodiments, the solid supported metal
carbonyl comprises the moiety Co(CO).sub.4.sup.-. In certain
embodiments, the cobalt compound is Co.sub.2(CO).sub.8 or a
compound derived therefrom. In certain embodiments, the solid
supported metal carbonyl is formed in situ from a suitable metal
salt. In certain embodiments, the solid supported metal carbonyl is
a compound resulting from the treatment of a metal or a metal salt
adsorbed on a solid support and then treated with carbon monoxide
under suitable conditions to convert at least a portion of the
metal or salt to metal carbonyl compounds. In certain embodiments,
the solid supported metal carbonyl is a compound resulting from the
treatment of cobalt metal or a cobalt salt adsorbed on a solid
support and then treated with carbon monoxide under suitable
conditions to convert at least a portion of the cobalt or cobalt
salt to cobalt carbonyl compounds.
[0109] The metal carbonyl concentration in the first reaction zone
is not particularly limited, but in light of the balance between
the conversion rate and selectivity, can range from about 0.005 to
about 20 mmol of metal carbonyl per cubic centimeter of solid
support volume. In certain embodiments, 0.1 to 5 mmol metal
carbonyl is present per cc of solid support.
[0110] In certain embodiments, the first reaction zone also
comprises other materials and/or additives such as metal salts,
acids, bases, Lewis basic organic compounds Lewis acidic organic
compounds Lewis acidic metal compounds and the like. In certain
embodiments, such additives increase the rate of the epoxide
carbonylation reaction relative to a reaction performed in a system
lacking such additives. In certain embodiments, the additives
comprise aluminum salts. In certain embodiments, the additives
comprise zinc salts. In certain embodiments, the additives comprise
transition metal salts. In certain embodiments, the additives
comprise metal ligand complexes including organic ligands such as
porphyrins, salens, and the like. In certain embodiments, the
additives comprise high molecular weight alcohols, organic acids or
amines. In certain embodiments, the additives comprise solid
supported materials. In certain embodiments, the additives comprise
solid-supported metal compounds, alcohols, organic acids or amines,
or onium salts.
[0111] In certain embodiments, a solid support in the first
reaction zone comprises an inorganic material. Many suitable
inorganic supports are known in the art and a skilled artisan will
recognize materials suitable for this purpose. In certain
embodiments, suitable inorganic solid supports include, but are not
limited to materials such as: silica, glass, alumina, zirconia,
diatomaceous earth, metal oxides, metal salts, ceramics, clays,
molecular sieves, kieselgur, titanium dioxide and the like. In
certain embodiments, the solid support in the first reaction zone
comprises silica gel. In certain embodiments, the solid support in
the first reaction zone comprises alumina. In certain embodiments,
the solid support in the first reaction zone comprises glass. In
certain embodiments, the solid support in the first reaction zone
comprises a ceramic. In certain embodiments, the solid support in
the first reaction zone comprises diatomaceous earth.
[0112] In other embodiments, a solid support in the first reaction
zone comprises a polymeric support. Suitable polymeric supports are
known in the art and a skilled artisan will recognize materials
suitable for this purpose. In certain embodiments, the polymeric
supports may comprise polystyrene, divinylbenzene,
polyvinylpyridine, polymethylmethacrylate, polyolefins,
polytetrafluoroethylene, and combinations or derivatives thereof.
In certain embodiments, the polymeric support comprises a cation
exchange resin. In certain embodiments, the polymeric support
comprises an anion exchange resin.
[0113] Carbonylation Reaction Conditions and Operation
[0114] In certain embodiments, the carbonylation reaction in the
first reaction zone is operated at least partially in a gas phase.
In these embodiments, the epoxide and carbon monoxide are fed into
the reactor as gasses at an inlet and a product stream containing
the beta lactone is removed from the reactor outlet. In certain
embodiments, the beta lactone stream is also removed in the gas
phase. In certain embodiments, the epoxide and carbon monoxide are
fed into the reactor as gasses and the beta lactone stream is
removed in the liquid phase. In these embodiments, the metal
carbonyl compound may be present as a solid or solid-supported
compound (heterogeneous catalysis).
[0115] The carbonylation reaction conditions are selected based on
a number of factors to effect conversion of the epoxide to a
beta-lactone. Temperature, pressure, and reaction time influence
reaction speed and efficiency. Additionally the ratio of reactants
to each other and to the catalyst effect reaction speed and
efficiency.
[0116] In certain embodiments, the carbonylation in the first
reaction zone is operated in a solution phase. In these
embodiments, the epoxide and carbon monoxide are fed into the
reactor at an inlet and a product stream containing the beta
lactone is removed via gas sweeping or volatilization from the
reactor outlet. Such a reactor can be operated as a boiling reactor
designs and operating parameters for which are available in the
art. In these embodiments, the metal carbonyl compound may be
present as a soluble compound (homogenous catalysis), optionally
dissolved in a solvent, or may be present as a solid or
solid-supported compound (heterogeneous catalysis). The reactants
may be fed as gas or a liquid or as combinations of these. In
certain embodiments where the first reaction zone is operated in a
solution phase, the reaction zone includes a high boiling reaction
medium such as a high boiling organic solvent or an ionic liquid
that remains in the reaction zone as the beta lactone is stripped
from the reactor outlet.
[0117] The first reaction zone is operated under positive carbon
monoxide pressure. In certain embodiments, a carbon monoxide
partial pressure in the first reaction zone ranges from about 0.5
atmospheres to about 500 atmospheres. In certain embodiments, a
carbon monoxide partial pressure in the first reaction zone ranges
from about 0.5 atmospheres to about 350 atmospheres. In certain
embodiments, the carbon monoxide partial pressure ranges from about
5 to about 100 atmospheres. In certain embodiments, the carbon
monoxide partial pressure ranges from about 10 to about 50
atmospheres, from about 5 to about 20 atmospheres, from about 1 to
about 10 atmospheres, or from about 5 to about 50 atmospheres. In
some embodiments, the pressure can range from about 0.5 atmospheres
to about 10 atmospheres (absolute). In some embodiments, the
pressure can range from about 0.5 atmospheres to about 50
atmospheres (absolute). In some embodiments, the pressure can range
from about 1 atmosphere to about 10 atmospheres (absolute). In some
embodiments, the pressure can range from about 1 atmosphere to
about 50 atmospheres (absolute). In some embodiments, the pressure
can range from about 1 atmosphere to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
10 atmospheres to about 50 atmospheres (absolute). In some
embodiments, the pressure can range from about 10 atmospheres to
about 100 atmospheres (absolute). In some embodiments, the pressure
can range from about 50 atmospheres to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
50 atmospheres to about 200 atmospheres (absolute). In some
embodiments, the pressure can range from about 100 atmospheres to
about 200 atmospheres (absolute). In some embodiments, the pressure
can range from about 100 atmospheres to about 250 atmospheres
(absolute). In some embodiments, the pressure can range from about
200 atmospheres to about 300 atmospheres (absolute). In some
embodiments, the pressure can range from about 200 atmospheres to
about 500 atmospheres (absolute). In some embodiments, the pressure
can range from about 250 atmospheres to about 500 atmospheres
(absolute).
[0118] In certain embodiments, the first reaction zone may comprise
one or more carbon monoxide inlets (i.e. carbon monoxide sources
independent from carbon monoxide that may be introduced admixed
with epoxide in the epoxide feedstock stream). In certain
embodiments, the epoxide and the carbon monoxide are introduced to
the first reaction zone via separate inlets. In some embodiments,
the reaction pressure is supplied entirely by the carbon monoxide.
For example, the reactants and catalyst are charged to the reactor
at atmospheric pressure, or under a vacuum, and carbon monoxide is
added to the reactor to increase pressure to the reaction pressure.
In some embodiments, all reactants are supplied to the reactor at
reaction pressure.
[0119] In certain embodiments, the first reaction zone is at a
temperature ranging from ambient to about 400.degree. C. In certain
embodiments, the first reaction zone is at a temperature ranging
from about 50.degree. C. to about 250.degree. C. In certain
embodiments, the temperature in the first reaction zone ranges from
about 40.degree. C. to about 200.degree. C. In certain embodiments,
the temperature in the first reaction zone ranges from about
50.degree. C. to about 150.degree. C. In certain embodiments, the
temperature in the first reaction zone ranges from about
100.degree. C. to about 220.degree. C. In certain embodiments, the
temperature in the first reaction zone ranges from about 60.degree.
C. to about 120.degree. C. In certain embodiments, the temperature
in the first reaction zone ranges from about 40.degree. C. to about
80.degree. C. In some embodiments, the temperature ranges from
about 50.degree. C. to 100.degree. C. In some embodiments, the
temperature ranges from about 50.degree. C. to 200.degree. C. In
some embodiments, the temperature ranges from about 100.degree. C.
to 150.degree. C. In some embodiments, the temperature ranges from
about 100.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 100.degree. C. to 250.degree. C. In
some embodiments, the temperature ranges from about 150.degree. C.
to 250.degree. C. In some embodiments, the temperature ranges from
about 150.degree. C. to 300.degree. C. In some embodiments, the
temperature ranges from about 200.degree. C. to 300.degree. C. In
some embodiments, the reactants and catalyst are supplied to the
reactor at standard temperature, and then heated in the reactor. In
some embodiments, the reactants are pre-heated before entering the
reactor.
[0120] In certain embodiments, the carbonylation in the first
reaction zone is operated in a gas phase. In these embodiments, the
epoxide and carbon monoxide are fed in the gas phase and the beta
lactone produced in the reaction is removed via gas sweeping. In
certain embodiments, the catalyst is a solid or solid supported.
Generally, gas phase reactions are devoid of any solvent for
reactants or catalyst. In certain embodiments, a gas phase in the
first reaction zone may comprise primarily carbon monoxide and
epoxide substrate, while in other embodiments, additional gases or
diluents may also be present. In certain embodiments, such diluents
may include nitrogen, hydrogen, hydrocarbon gases or the like. In
certain embodiments, the atmosphere in the first reaction zone is
essentially free of oxygen. In certain embodiments, the atmosphere
in the first reaction zone is essentially free of water. In certain
embodiments, the atmosphere in the first reaction zone is
essentially free of water and oxygen.
[0121] In some embodiments, the carbonylation reaction is performed
in a continuous operation. The reactants are continuously fed to
the first reaction zone. In some embodiments, the reactor includes
a gas-entrainment impeller. The reactants may be fed to the reactor
at standard temperature and pressure and then heated or pressurized
to reaction conditions once in the reactor. The reactor itself may
be any reactor conducive to continuous operation, including by not
limited to a continuously stirred tank reactor or a tubular
reactor. In some embodiments, the reactor is an adiabatic reactor,
and/or an isothermal reactor. In some embodiments, the reactor
pressure is constant. In some embodiments, the reactor pressure
varies as the reaction progresses. In some embodiments, the reactor
temperature varies as the reaction progress. In some embodiments,
the reaction is performed in a batch operation. One of ordinary
skill in the art will recognize the temperatures, pressures,
catalyst ratios, concentrations of reactants, catalyst and
solvents, flow rates can all be optimized or varied to achieve a
given reaction outcome.
[0122] In some embodiments, the reaction is maintained for a period
of time sufficient to allow complete, near complete reaction of the
epoxide to beta-lactone or as complete as possible based on the
reaction kinetics and or reaction conditions. In some embodiments,
the reaction time is established as a residence time within the
reactor. The reaction can be halted by reducing the reactor
temperature or pressure, withdrawing a particular reactant or
introducing a quenching compound. The reaction may be halted at any
point or any percentage conversion of epoxide to beta-lactone.
E.g., the reaction may be halted when 50% of the epoxide is
converted to beta-lactone.
[0123] In one embodiment of the method, the epoxide comprises
ethylene oxide, which is combined with carbon monoxide and reacted
over a cobalt-based catalyst or precatalyst, such as dicobalt
octacarbonyl, cobalt nitrate, cobalt acetate, cobalt chloride, or
similar compounds, on a support consisting of silica gel, alumina,
a zeolite or polymeric material, at a temperature of 50-200.degree.
C. and a pressure of 10-200 atmospheres to produce beta
propiolactone. The reaction, being run with an excess of carbon
monoxide, can result in almost total depletion of ethylene oxide.
The less volatile beta propiolactone can be separated from
unreacted carbon monoxide vapor stream by condensation and then fed
directly to the next step. In another alternative, if the
carbonylation reaction is run to the complete depletion of ethylene
oxide, the entire effluent mixture of carbon monoxide containing
the product beta propiolactone can be fed directly to the next step
in a gaseous phase.
[0124] In certain embodiments, it may be desirable to operate the
first reaction zone of the process in a series of stages. In one
such embodiment, the first reaction zone (e.g., carbonylation) is
separated into a plurality of individual reaction zones wherein
each reaction zone achieves partial conversion of the epoxide in
the feedstream to beta lactone. The unreacted epoxide and carbon
monoxide exiting one reaction zone is then fed to the inlet of the
next reaction zone. In certain embodiments, beta lactone formed in
one stage is partially or wholly removed from the reaction stream
prior to feed of the next stage. In this way, a balance can be
achieved between consumption of epoxide feedstock and formation of
lactone-derived byproducts since under some conditions higher
conversion leads to greater formation of undesired byproducts. In
certain embodiments, the individual reaction zones within the
reactor are separated by a lower temperature zone from which the
lactone condenses and is separated from the reaction stream before
it enters the next reaction zone. In certain embodiments, the
individual reaction zones in such a reactor decrease in size such
that each stage is sized to efficiently accommodate the fraction of
unreacted epoxide exiting the prior stage from which it is fed. In
certain embodiments, the carbonylation reaction zone comprises
between 2 and 20 individual reaction stages. In embodiments, where
lactone is separated between stages, the resulting plurality of
lactone streams can each feed the lactone conversion stage of the
process, or they can be combined into one stream.
[0125] Carbonylation Reaction Products
[0126] As described above, the primary reaction product of the
carbonylation reaction is a beta-lactone. Additionally, the product
stream may contain other reaction by-products, un-reacted
reactants, as well as catalyst and solvent. In some embodiments,
the un-reacted reactants include epoxide or carbon monoxide. As
such, the reaction may not proceed to completion and may be
considered a partial reaction.
[0127] In some embodiments, the amount of un-reacted epoxide is
sufficient to prevent the formation of a succinic anhydride, a
potential carbonylation reaction byproduct. Without being bound by
a particular theory, it is speculated that the second reaction
converting the beta-lactone to succinic anhydride does not proceed,
unless all of the epoxide is consumed. Thus, a remaining percent of
the epoxide feed to the reactor that exits un-reacted appears to
prevent the formation of succinic anhydride. In some embodiments,
the product stream contains less than about 5% epoxide, less than
about 3% epoxide, less than about 1% epoxide or less than about
0.1%. Note, all percentages are applicable on either a mole basis,
weight basis, or volume basis, per reaction conditions may
dictate.
[0128] In some embodiments, by-product formation includes the
formation of succinic anhydride. In some embodiments, by-product
formation includes the formation of one or more of the following
compounds: crotonaldehyde, acrylic acid, 1,4 dioxane, acrylic acid
dimers and trimers, 2-hydroxyethyl acrylate, 2,5 hexandienal,
3-oxacaprolactone, diethylene glycol monoacrylate,
3-hydroxypropionic acid, diethylene glycol diacrylate,
5-valeroactone and/or 2,6-dimethyl-1,3-dioxan-4-ol.
Lactone Conversion
[0129] Generally
[0130] In the next stage of processes of the invention, the
effluent from the carbonylation reaction zone is fed to a second
reaction zone where the beta lactone is subjected to conditions
that convert it to a compound selected from the group consisting
of: an alpha beta unsaturated acid, an alpha beta unsaturated
ester, an alpha beta unsaturated amide, and a polymer. The second
reaction stage is alternately referred to herein as the beta
lactone conversion stage.
[0131] The beta lactone stream resulting from the carbonylation
step is carried onto a lactone conversion step in a second reaction
zone. The lactone conversion step is discussed in more detail
below. The beta-lactone stream may optionally be processed in a
number ways prior to the lactone conversion step. This processing
can include, but is not limited to: heating, cooling, or
compressing the stream; condensing the stream to a liquid state and
carrying forward the liquid; adding a polymerization inhibitor to
the stream; condensing selected components to a liquid state and
carrying forward the remaining gaseous components; condensing
selected components to a liquid state and carrying forward the
liquefied components; scrubbing the stream to remove impurities;
adding reactants/catalysts for lactone conversion reactions; and
any combination of two or more of these.
[0132] In certain embodiments, the beta lactone is first separated
from more volatile components in the product stream exiting the
first reaction zone by condensing it to a liquid. This is easily
achieved by cooling the product stream and/or increasing the
pressure. In other embodiments, the entire effluent of the
carbonylation stage is carried to the second reaction stage without
any separation stage. This embodiment is particularly applicable if
all of the epoxide has been consumed in which case the product
stream exiting the carbonylation stage comprises essentially beta
lactone and carbon monoxide (optionally mixed with other gases or
volatile compounds if they were present at the feed or generated in
situ).
[0133] Turning next to the lactone conversion step, the
beta-lactone stream discussed above is carried onward to a second
reaction zone to convert the beta lactone contained therein to any
of several end products described in more detail below. As
discussed above, in some embodiments, the beta-lactone stream may
undergo additional processing steps between the carbonylation step
and may enter the lactone conversion stage of the process as a gas
or as a liquid. The lactone conversion step itself may be performed
in either the gas phase or the liquid phase and may be performed
neat, or in the presence of a carrier gas, solvent or other
diluent.
[0134] In certain embodiments, the lactone conversion step is
performed in a continuous flow format. In certain embodiments, the
lactone conversion step is performed in a continuous flow format in
the gas phase. In certain embodiments, the lactone conversion step
is performed in a continuous flow format in the liquid phase. In
certain embodiments, the lactone conversion step is performed in a
liquid phase in a batch or semi-batch format. The lactone
conversion step may be performed under a variety of conditions. In
certain embodiments, the reaction may be performed in the presence
of one or more catalysts that facilitate one or more steps in the
transformation of the beta lactone to the end product.
[0135] In certain embodiments, the beta-lactone conversion stage is
fed with a feed stream containing less than 5 percent epoxide
(relative to beta lactone). In certain embodiments, the
beta-lactone conversion stage is fed with a feed stream containing
less than 2 percent epoxide. In certain embodiments, the
beta-lactone conversion stage is fed with a feed stream containing
less than 1 percent epoxide, less than 0.5 percent epoxide, less
than 0.25 percent epoxide, less than 0.1 percent epoxide, or less
than 0.05 percent epoxide. In certain embodiments, the beta-lactone
conversion stage is fed with a feed stream containing essentially
no unreacted epoxide. Note, all percentages are applicable on
either a mole basis, weight basis, or volume basis, per reaction
conditions may dictate.
[0136] In certain embodiments, the beta lactone conversion step
comprises a solid catalyst and the conversion is conducted at least
partially in the gas stage. In certain embodiments, the solid
catalyst in the beta lactone conversion stage comprises a solid
acid catalyst. In certain embodiments, the beta lactone is
introduced as a liquid and contacted with the solid catalyst and
the carboxylic acid (e.g., acrylic acid) or acid derivative (e.g.,
acrylic acid derivative) is removed as a gaseous stream. In other
embodiments, the beta lactone is introduced as a gas, contacted
with the solid catalyst and acrylic acid or an acrylic acid
derivative is removed as a gaseous stream. In a specific
embodiment, a mixture of beta propiolactone and water are contacted
with a solid acid catalyst and gaseous acrylic acid is withdrawn
from the reaction zone. In certain embodiments, a mixture of beta
propiolactone and a lower alcohol are contacted with a solid acid
catalyst and gaseous acrylate ester is withdrawn from the reaction
zone.
[0137] In certain embodiments, the processes above are
characterized in that the feed rates, reaction rates, and reactor
sizes are scaled such that each subsequent stage in the process can
utilize essentially all of the effluent from the previous stage. In
certain embodiments, the methods include one or more steps of
modulating one or more system parameters selected from the group
consisting of: the ethylene and oxygen feed rates and/or ratios,
the ethylene oxidation zone reaction temperature, the carbon
monoxide feed rate, the carbonylation stage temperature, the
carbonylation stage reaction pressure, the feed rate of one or more
reactants entering the lactone conversion stage, the temperature
and/or pressure of the lactone conversion stage, and a combination
of any two or more of these parameters. In certain embodiments,
this modulation of system parameters is performed such that the
conversion rate per unit time of each stage matches that of the
previous stage so that the effluent of the previous stage may be
used directly to feed the subsequent stage. In certain embodiments,
the methods include one or more steps of analyzing the effluent
from one or more stages to assess its content. In certain
embodiments, such analyzing steps include performing spectroscopy
(e g infrared spectroscopy, nuclear magnetic resonance
spectroscopy, ultraviolet or visible light spectroscopy and the
like), chromatography (e.g. gas or liquid chromatography). In
certain embodiments, such analyses are performed in a flow-through
or stop-flow mode that provides real-time data on the chemical
composition of the effluent. In certain embodiments, such data are
used to provide a prompt to adjust one or more of the system
parameters described above.
[0138] Carboxylic Acid Production
[0139] In certain embodiments, the product of the beta lactone
conversion stage is an alpha beta unsaturated carboxylic acid or
ester. There are a number of options possible for the way in which
beta lactones can undergo thermolysis or alcoholoysis to a
carboxylic acid (e.g., acrylic acid) or an ester (e.g., acrylate
esters), respectively. In one embodiment, beta propiolactone is fed
directly to a reactor containing heated phosphoric acid, optionally
including copper metal, a copper salt or other catalyst, to produce
acrylic acid vapors that are continuously removed to avoid the
formation of unwanted byproducts. The formation of acrylic acid can
be run at atmospheric, super-atmospheric or sub-atmospheric
pressures, at temperatures as high as 300.degree. C. The acrylic
acid produced is then condensed and purified by any of the methods
known to one skilled in the art. Additional compounds useful in
converting beta lactones to carboxylic acids include, but are not
limited to sulfuric acid, zinc chloride, sodium bisulfate, boric
acid, boric anhydride, phosphorus pentoxide as well as metallic
catalysis such as, aluminum oxide, iron oxides, titanium oxides,
etc.,. Further, basic catalysis may be use including calcium
hydroxide, magnesium oxide, borax, disodium phosphate, etc.,.
[0140] In certain embodiments, water may be added to this process
to act as a catalyst. Without being bound by theory or limiting the
scope of the present invention, it is believed water can aid this
conversion by opening the beta lactone to form a beta hydroxy acid
intermediate which then dehydrates to provide the desired alpha
beta unsaturated acid and regenerate the water. The water may be
added to the beta lactone stream before entering the second
reaction zone, or it may be present in (or added independently to)
the second reaction zone. In certain embodiments, the conversion of
beta propiolactone to acrylic acid is performed using methods such
as those disclosed in U.S. Pat. Nos. 3,176,042, 2,485,510,
2,623,067, 2,361,036 each of which is incorporated herein by
reference. In other embodiments, the acrylate production may be
base catalyzed, see for example Journal of Organic Chemistry,
57(1), 389-91(1992) and references therein, the entirety of which
is incorporated herein by reference.
[0141] Many catalysts known in the art can be used, or adapted for
this step. In some embodiments, conditions include reaction with
dehydrating agents such as sulfuric acid, phosphoric acid or esters
thereof as described in U.S. Pat. Nos. 2,352,641; 2,376,704;
2,449,995; 2,510,423; 2,623,067; 3,176,042, and in British Patent
No. GB 994,091, the entirety of each of which is incorporated
herein by reference.
[0142] In other embodiments, the lactone can be reacted with a
halogenic compound to yield a beta halo acid, beta halo ester, or
beta halo acid halide, which may then undergo dehydrohalogenation
and/or solvolysis to afford the corresponding acrylic acid or
acrylic ester. In certain embodiments, conditions disclosed in U.S.
Pat. No. 2,422,728 (incorporated herein by reference) are used in
this process.
[0143] Similarly, several methods can be employed to convert a beta
lactone to an alpha beta unsaturated ester. For example, most
methods use an alcohol in the beta lactone conversion stage (or
added to the beta lactone stream before it is fed to this stage) to
facilitate ring opening of the beta lactone to a beta hydroxy
ester, or beta alkoxy acid, both of which can convert to alpha beta
unsaturated esters. In certain embodiments, the lactone conversion
step is performed in the presence of an alcohol. In certain
embodiments, the lactone conversion step is performed in the
presence of a C.sub.1-20 alcohol. In certain embodiments, the
lactone conversion step is performed in the presence of a C.sub.1-8
alcohol. In certain embodiments, the lactone conversion step is
performed in the presence of an alcohol selected from the group
consisting of: methanol, ethanol, propanol, butanol, hexanol, and
2-ethyl-hexanol. In some embodiments, the alcohol used is a heptyl
alcohol, an octyl alcohol, a nonyl alcohol, an n-decyl alcohol, an
n-undecyl alchol, a cetyl alcohol, an n-coded alchol, an
n-tetradecyl alcohol and other primary alcohols. Further, other
alcohols can be used in the beta propiolactone conversion step, for
example, sec-butyl alcohol, tert-butyl alcohol, allyl alcohol,
beta-ethoxy-ethyl alcohol, diethylene glycol monoethyl either,
cycloheanol, furfuryl alcohol benzyl alcohol, and ethylene glycol
among others as described above.
[0144] The beta lactone conversion is generally performed in the
presence of a catalyst. For example, in some embodiments, the beta
lactone is reacted with an alcohol in the presence of a dehydrating
catalyst. Exemplary dehydrating catalysts include, but are not
limited to: metal oxides (e.g., aluminum oxides, titanium oxides),
zeolites, silica, and alumino-silicates, among others. Typically,
such a conversion is performed in the liquid phase, and the product
esters are isolated by distillation.
[0145] In some embodiments, the beta lactone conversion can be
performed with activated carbon as a catalyst to produce alpha beta
unsaturated esters. In some embodiments, the beta lactone is
reacted with an alcohol in the gas phase and over an activated
carbon catalyst to produce esters. The activated carbon can be
supplied in any form, for example, powdered, granulated, extruded,
beads, impregnated with other elements (e.g., iodine, silver,
metallic cations, etc.).
[0146] In some embodiments, the reaction may include a
polymerization inhibitor to prevent the formation of polymers.
Exemplary polymerization inhibitors include copper, copper salts,
hydroquinone, manganese, manganese salts, chromium, and chromium
salts.
[0147] As described above, the beta lactone conversion step can be
operated within a variety of temperature and pressure ranges when
alpha beta unsaturated carboxylic acid or ester are the desired
products. In some embodiments, the temperature can range from about
0.degree. C. to about 300.degree. C. In some embodiments, the
temperature ranges from about 0.degree. C. to 50.degree. C. In some
embodiments, the temperature ranges from about 0.degree. C. to
100.degree. C. In some embodiments, the temperature ranges from
about 0.degree. C. to 150.degree. C. In some embodiments, the
temperature ranges from about 0.degree. C. to 200.degree. C. In
some embodiments, the temperature ranges from about 50.degree. C.
to 100.degree. C. In some embodiments, the temperature ranges from
about 50.degree. C. to 150.degree. C. In some embodiments, the
temperature ranges from about 50.degree. C. to 200.degree. C. In
some embodiments, the temperature ranges from about 100.degree. C.
to 150.degree. C. In some embodiments, the temperature ranges from
about 100.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 100.degree. C. to 250.degree. C. In
some embodiments, the temperature ranges from about 150.degree. C.
to 250.degree. C. In some embodiments, the temperature ranges from
about 150.degree. C. to 300.degree. C. In some embodiments, the
temperature ranges from about 200.degree. C. to 300.degree. C.
[0148] In some embodiments, the pressure can range from about 0.01
atmospheres to about 500 atmospheres (absolute). In some
embodiments, the pressure can range from about 0.01 atmospheres to
about 10 atmospheres (absolute). In some embodiments, the pressure
can range from about 0.01 atmospheres to about 50 atmospheres
(absolute). In some embodiments, the pressure can range from about
1 atmosphere to about 10 atmospheres (absolute). In some
embodiments, the pressure can range from about 1 atmosphere to
about 50 atmospheres (absolute). In some embodiments, the pressure
can range from about 1 atmosphere to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
10 atmospheres to about 50 atmospheres (absolute). In some
embodiments, the pressure can range from about 10 atmospheres to
about 100 atmospheres (absolute). In some embodiments, the pressure
can range from about 50 atmospheres to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
50 atmospheres to about 200 atmospheres (absolute). In some
embodiments, the pressure can range from about 100 atmospheres to
about 200 atmospheres (absolute). In some embodiments, the pressure
can range from about 100 atmospheres to about 250 atmospheres
(absolute). In some embodiments, the pressure can range from about
200 atmospheres to about 300 atmospheres (absolute). In some
embodiments, the pressure can range from about 200 atmospheres to
about 500 atmospheres (absolute). In some embodiments, the pressure
can range from about 250 atmospheres to about 500 atmospheres
(absolute).
[0149] Applicants note that U.S. Pat. Nos. 2,466,501, 2,376,704
each of which is incorporated herein by reference in its entirety,
describe methods of producing alpha beta unsaturated esters from
beta lactones.
[0150] Unsaturated Amides
[0151] Alternatively, ammonia or an organic amine may be present in
this stage to facilitate ring opening of the beta lactone to a beta
hydroxy amide, which can be converted to alpha beta unsaturated
amides. In certain embodiments, the lactone conversion is performed
in the presence of ammonia to produce acrylamide. In certain
embodiments, the lactone conversion is performed in the presence of
a C.sub.1-20 amine to produce N-substituted acrylamide derivatives.
Exemplary amines include but are not limited to methyl amine, ethyl
amine, propyl amines, butyl amines, amyl amines, and dialkyl
amines. In some embodiments, the amine and the beta lactone are
both soluble in water.
[0152] As described above, the beta lactone conversion step can be
operated within a variety of temperature and pressure ranges when
alpha beta unsaturated amides are the desired products. Some of the
reactions are exothermic and therefore lower temperatures may be
useful, as well as sufficient heat transfer to control reaction
temperature. As described above, the beta lactone conversion step
can be operated within a variety of temperature and pressure ranges
when alpha beta unsaturated amides are the desired products. In
some embodiments, the temperature can range from about 0.degree. C.
to about 300.degree. C. In some embodiments, the temperature ranges
from about 0.degree. C. to 50.degree. C. In some embodiments, the
temperature ranges from about 0.degree. C. to 100.degree. C. In
some embodiments, the temperature ranges from about 0.degree. C. to
150.degree. C. In some embodiments, the temperature ranges from
about 0.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 50.degree. C. to 100.degree. C. In
some embodiments, the temperature ranges from about 50.degree. C.
to 150.degree. C. In some embodiments, the temperature ranges from
about 50.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 100.degree. C. to 150.degree. C. In
some embodiments, the temperature ranges from about 100.degree. C.
to 200.degree. C. In some embodiments, the temperature ranges from
about 100.degree. C. to 250.degree. C. In some embodiments, the
temperature ranges from about 150.degree. C. to 250.degree. C. In
some embodiments, the temperature ranges from about 150.degree. C.
to 300.degree. C. In some embodiments, the temperature ranges from
about 200.degree. C. to 300.degree. C.
[0153] In some embodiments, the pressure can range from about 0.01
atmospheres to about 500 atmospheres (absolute). In some
embodiments, the pressure can range from about 0.01 atmospheres to
about 10 atmospheres (absolute). In some embodiments, the pressure
can range from about 0.01 atmospheres to about 50 atmospheres
(absolute). In some embodiments, the pressure can range from about
1 atmosphere to about 10 atmospheres (absolute). In some
embodiments, the pressure can range from about 1 atmosphere to
about 50 atmospheres (absolute). In some embodiments, the pressure
can range from about 1 atmosphere to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
10 atmospheres to about 50 atmospheres (absolute). In some
embodiments, the pressure can range from about 10 atmospheres to
about 100 atmospheres (absolute). In some embodiments, the pressure
can range from about 50 atmospheres to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
50 atmospheres to about 200 atmospheres (absolute). In some
embodiments, the pressure can range from about 100 atmospheres to
about 200 atmospheres (absolute). In some embodiments, the pressure
can range from about 100 atmospheres to about 250 atmospheres
(absolute). In some embodiments, the pressure can range from about
200 atmospheres to about 300 atmospheres (absolute). In some
embodiments, the pressure can range from about 200 atmospheres to
about 500 atmospheres (absolute). In some embodiments, the pressure
can range from about 250 atmospheres to about 500 atmospheres
(absolute).
[0154] Applicants note that U.S. Pat. No. 2,548,155, which is
incorporated herein by reference in its entirety, describes methods
of producing alpha beta unsaturated amides from beta lactones.
[0155] Polymerization
[0156] In another embodiment of the present invention, the beta
lactone from the carbonylation step is fed into a subsequent stage
comprising a polymerization catalyst. This provides the opportunity
to produce biodegradable polyesters such as poly(3-hydroxy
butyrate) (P-3HB), and poly(propiolactone) without the need to
handle and transport beta lactones. Many catalysts are known for
the ring-opening polymerization of lactones (such as caprolactone
and beta lactones). Any such catalyst can be employed in the
present process.
[0157] Catalysts suitable for the ring-opening polymerization step
of the methods disclosed herein are disclosed, for example, in:
Journal of the American Chemical Society (2002), 124(51),
15239-15248 Macromolecules, vol. 24, No. 20, pp. 5732-5733, Journal
of Polymer Science, Part A-1, vol. 9, No. 10, pp. 2775-2787; Inoue,
S., Y. Tomoi, T. Tsuruta & J. Furukawa; Macromolecules, vol.
26, No. 20, pp. 5533-5534; Macromolecules, vol. 23, No. 13, pp.
3206-3212; Polymer Preprints (1999), 40(1), 508-509;
Macromolecules, vol. 21, No. 9, pp. 2657-2668; and Journal of
Organometallic Chemistry, vol. 341, No. 1-3, pp. 83-9; and in U.S.
Pat. Nos. 3,678,069, 3,169,945, 6,133,402; 5,648,452; 6,316,590;
6,538,101; and 6,608,170. The entirety of each of which is hereby
incorporated herein by reference.
[0158] In certain embodiments where the beta lactone conversion
step comprises polymerizing the beta lactone, the step includes the
step of contacting the beta lactone with a polymerization catalyst,
optionally in the presence of one or more solvents. Suitable
solvents can include, but are not limited to: hydrocarbons, ethers,
esters, ketones, nitriles, amides, sulfones, halogenated
hydrocarbons, and the like. In certain embodiments, the solvent is
selected such that the polymer formed is soluble in the reaction
medium.
[0159] In certain embodiments where the beta lactone conversion
step comprises polymerizing the beta lactone to form a polyester,
the step comprises a continuous polymerization. Such continuous
polymerizations can be conducted in a continuous stirred tank
reactor or a plug flow reactor such that polymer or polymer
solution is withdrawn at essentially the same rate it is formed.
Polymerization of lactones to polyester can be performed with a
number of polymerization initiators including but not limited to
alcohols, amines, polyols, polyamines, and diols, amongst others.
Further a variety of catalysts may be used in the polymerization
reaction, including by not limited to metals (e.g., lithium,
sodium, potassium, magnesium, calcium, zinc, aluminum, titanium,
cobalt, etc..) metal oxides, carbonates of alkali- and alkaline
earth metals, borates, silicates, of various metals.
[0160] As described above, the beta lactone conversion step can be
operated within a variety of temperature and pressure ranges when
polyesters are the desired products. As described above, the beta
lactone conversion step can be operated within a variety of
temperature and pressure ranges when alpha beta unsaturated
carboxylic acid or ester are the desired products. In some
embodiments, the temperature can range from about 0.degree. C. to
about 300.degree. C. In some embodiments, the temperature ranges
from about 0.degree. C. to 50.degree. C. In some embodiments, the
temperature ranges from about 0.degree. C. to 100.degree. C. In
some embodiments, the temperature ranges from about 0.degree. C. to
150.degree. C. In some embodiments, the temperature ranges from
about 0.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 50.degree. C. to 100.degree. C. In
some embodiments, the temperature ranges from about 50.degree. C.
to 150.degree. C. In some embodiments, the temperature ranges from
about 50.degree. C. to 200.degree. C. In some embodiments, the
temperature ranges from about 100.degree. C. to 150.degree. C. In
some embodiments, the temperature ranges from about 100.degree. C.
to 200.degree. C. In some embodiments, the temperature ranges from
about 100.degree. C. to 250.degree. C. In some embodiments, the
temperature ranges from about 150.degree. C. to 250.degree. C. In
some embodiments, the temperature ranges from about 150.degree. C.
to 300.degree. C. In some embodiments, the temperature ranges from
about 200.degree. C. to 300.degree. C.
[0161] In some embodiments, the pressure can range from about 0.01
atmospheres to about 500 atmospheres (absolute). In some
embodiments, the pressure can range from about 0.01 atmospheres to
about 10 atmospheres (absolute). In some embodiments, the pressure
can range from about 0.01 atmospheres to about 50 atmospheres
(absolute). In some embodiments, the pressure can range from about
1 atmosphere to about 10 atmospheres (absolute). In some
embodiments, the pressure can range from about 1 atmosphere to
about 50 atmospheres (absolute). In some embodiments, the pressure
can range from about 1 atmosphere to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
10 atmospheres to about 50 atmospheres (absolute). In some
embodiments, the pressure can range from about 10 atmospheres to
about 100 atmospheres (absolute). In some embodiments, the pressure
can range from about 50 atmospheres to about 100 atmospheres
(absolute). In some embodiments, the pressure can range from about
50 atmospheres to about 200 atmospheres (absolute). In some
embodiments, the pressure can range from about 100 atmospheres to
about 200 atmospheres (absolute). In some embodiments, the pressure
can range from about 100 atmospheres to about 250 atmospheres
(absolute). In some embodiments, the pressure can range from about
200 atmospheres to about 300 atmospheres (absolute). In some
embodiments, the pressure can range from about 200 atmospheres to
about 500 atmospheres (absolute). In some embodiments, the pressure
can range from about 250 atmospheres to about 500 atmospheres
(absolute).
[0162] Applicants note that U.S. Pat. Nos. 3,169,945 &
3,678,069, each of which is incorporated herein by reference in its
entirety, describe methods of producing polyesters from beta
lactones.
[0163] Specific Integrated Embodiments
[0164] Combining concepts and details described above, the present
invention encompasses the following methods:
[0165] A method for the synthesis of acrylic acid comprising the
steps of: [0166] 1) providing a gaseous feedstock stream comprising
ethylene oxide and carbon monoxide; [0167] 2) directing the
feedstock stream to a first reaction zone where it is contacted
with a metal carbonyl compound and where at least a portion of the
ethylene oxide is converted to a product stream comprising beta
propiolactone; [0168] 3) optionally adding water to the product
stream comprising beta propiolactone; [0169] 4) directing the
product stream comprising beta propiolactone to a second reaction
zone where it is contacted with a catalyst which catalyzes the
conversion of beta propiolactone to acrylic acid; [0170] 5)
withdrawing an acrylic acid product stream from the second reaction
zone; and [0171] 6) isolating acrylic acid from the product
stream.
[0172] A method for the synthesis of acrylate esters comprising the
steps of: [0173] 1) providing a gaseous feedstock stream comprising
ethylene oxide and carbon monoxide; [0174] 2) directing the
feedstock stream to a first reaction zone where it is contacted
with a metal carbonyl compound and at least a portion of the
ethylene oxide is converted to a product stream comprising beta
propiolactone; [0175] 3) adding a C.sub.1-8 alcohol to the product
stream comprising beta propiolactone; [0176] 4) directing the
product stream comprising beta propiolactone and the C.sub.1-8
alcohol to a second reaction zone where it is contacted with a
catalyst which catalyzes the conversion of beta propiolactone and
the C.sub.1-8 alcohol to the corresponding acrylic acid ester;
[0177] 5) withdrawing an acrylic acid ester product stream from the
second reaction zone; and [0178] 6) isolating acrylic acid ester
from the product stream.
[0179] A method for the synthesis of polypropiolactone comprising
the steps of: [0180] 1) providing a gaseous feedstock stream
comprising ethylene oxide and carbon monoxide; [0181] 2) directing
the feedstock stream to a first reaction zone where it is contacted
with a metal carbonyl compound and at least a portion of the
ethylene oxide is converted to a product stream comprising beta
propiolactone; [0182] 3) directing the product stream comprising
beta propiolactone to a polymerization reactor containing a
suitable solvent and a polymerization catalyst; [0183] 4)
withdrawing a polypropiolactone product stream from the
polymerization reactor; and [0184] 5) isolating polypropiolactone
from the product stream.
[0185] In certain embodiments, the above methods for the synthesis
of acrylic acid, acrylate esters, or polypropiolactone comprise the
additional step before step (1) of oxidizing ethylene to provide
ethylene oxide. In certain embodiments, such a step comprises the
substeps of contacting ethylene with oxygen in an ethylene
oxidation reactor in the presence of a suitable catalyst to convert
at least a portion of the ethylene to ethylene oxide, withdrawing a
gaseous ethylene oxide stream from the ethylene oxidation reactor;
and combining the gaseous ethylene oxide stream with carbon
monoxide to provide the feedstock stream.
[0186] In certain embodiments, in the above methods for the
synthesis of acrylic acid, acrylate esters, or polypropiolactone,
the step of directing the product stream comprising beta
propiolactone to the next reaction step comprises feeding the beta
propiolactone as a gas. In certain embodiments, the step of
directing the product stream comprising beta propiolactone to the
next reaction step comprises feeding the beta propiolactone as a
liquid.
[0187] A method for the synthesis of poly-3-hydroxybutyrate
comprising the steps of: [0188] 1) providing a gaseous feedstock
stream comprising propylene oxide and carbon monoxide; [0189] 2)
directing the feedstock stream to a first reaction zone where it is
contacted with a metal carbonyl compound and at least a portion of
the propylene oxide is converted to a product stream comprising
beta butyrolactone; [0190] 3) directing the product stream
comprising beta butyrolactone to a polymerization reactor
containing a suitable solvent and a polymerization catalyst; [0191]
4) withdrawing a poly-3-hydroxybutyrate product stream from the
polymerization reactor; and [0192] 5) isolating
poly-3-hydroxybutyrate from the product stream.
[0193] In certain embodiments, the feedstock stream provided in the
above method for the synthesis of poly-3-hydroxybutyrate comprises
enantio-enriched propylene oxide.
[0194] In certain embodiments, in the above methods for the
synthesis of acrylic acid, acrylate esters, polypropiolactone, or
poly-3-hydroxybutyrate, the metal carbonyl compound in the first
reaction zone comprises a cobalt carbonyl compound. In certain
embodiments, the metal carbonyl compound in the first reaction zone
comprises a rhodium carbonyl compound.
II) Systems of the Invention
[0195] In another aspect, the present invention provides systems
for the synthesis of acrylic acid or acrylic acid derivatives. In
certain embodiments, the system comprises: [0196] a first reactor,
comprising an inlet fed by an epoxide source and a carbon monoxide
source; a catalyst bed comprising one or more metal carbonyl
compounds; and a reactor outlet which provides an outlet stream
comprising a beta lactone; and [0197] a second reactor comprising
an inlet fed by the outlet stream of the first reaction zone; a
catalyst bed comprising an acid catalyst where the water and the
beta lactone are reacted to provide an alpha beta unsaturated acid;
and a reactor outlet which provides a product stream comprising
alpha beta unsaturated acid.
[0198] In certain embodiments, the second reactor in the system
above further comprises a water inlet. In certain embodiments, the
system above further comprises a condenser with an inlet fed by the
product stream of the second reactor and an outlet from which a
liquid alpha beta unsaturated acid product is withdrawn.
[0199] In another embodiment, the present invention provides
systems for the synthesis of acrylic acid esters. In certain
embodiments, the system comprises: [0200] a first reactor,
comprising an inlet fed by an epoxide source and a carbon monoxide
source; a catalyst bed comprising one or more metal carbonyl
compounds; and a reactor outlet which provides an outlet stream
comprising a beta lactone; and [0201] a second reactor comprising a
first inlet fed by the outlet stream of the first reaction zone; a
second inlet fed with a C.sub.1-8 alcohol, a catalyst bed
comprising a catalyst where the alcohol and the beta lactone are
reacted to provide an alpha beta unsaturated ester; and a reactor
outlet which provides a product stream comprising alpha beta
unsaturated ester.
[0202] In another embodiment, the present invention provides
systems for the synthesis of polyesters. In certain embodiments,
the system comprises: [0203] a first reactor, comprising an inlet
fed by an epoxide source and a carbon monoxide source; a catalyst
bed comprising one or more metal carbonyl compounds; and a reactor
outlet which provides an outlet stream comprising a beta lactone;
and [0204] a second reactor comprising a first inlet fed by the
outlet stream of the first reaction zone; a catalyst solution
comprising a polymerization catalyst and a solvent, and a reactor
outlet, which provides a product stream comprising a solution of
polyester polymer.
[0205] Some of the optional but non-limiting configurations of the
processes described above are shown in FIGS. 1 and 2.
[0206] In FIG. 1, carbon monoxide (1) and an epoxide (e.g.,
ethylene oxide (2)) are mixed and fed the carbonylation reactor (3)
which contains a supported catalyst (e.g., cobalt catalyst). The
configuration of the reactor can take many forms, as one skilled in
the art recognizes, including a catalyst bed or catalyst filled
tubes, which are situated within containing vessels, etc. Provision
for heat transfer, temperature and pressure control, etc., are
details that are not included but as one skilled in the art would
recognized, are a vital part of any reactor system design.
[0207] The product gas (4) contains unreacted carbon monoxide and
product beta lactone (e.g., beta propiolactone). In a particular
mode of operation, the reaction is run with a large excess of
carbon monoxide, the effluent gas (4) contains no (or only minor
amounts of) residual unreacted epoxide.
[0208] The effluent gas (4) is then fed directly to the thermolysis
reactor (5) which contains a suitable catalyst for the conversion
of the beta lactone (e.g., beta propiolactone) to a carboxylic acid
(e.g., acrylic acid). For example, the thermolysis reactor could be
a vessel containing a hot phosphoric acid/catalyst solution at a
suitable temperature and pressure that acrylic acid is produced. As
the acid is formed, it is removed as a vapor product, which is
subsequently separated by known methods into gaseous stream
containing mainly unreacted carbon monoxide (9), and a crude
carboxylic acid product (10) which would undergo further
purification to the required specifications by methods well known
to those in the field. Alternately, thermolysis reactor could
comprise a heterogeneous catalyst such as a solid supported acid
and the conversion of beta lactone (e.g., beta propiolactone) to a
carboxylic acid (e.g., acrylic acid) can be performed with the
lactone and the carboxylic acid substantially in the gas phase.
[0209] A purge stream (8) taken from the thermolysis reactor
provides a way of preventing the buildup of heavy byproducts and
spent catalyst. Make-up catalyst (not shown in FIG. 1) would
periodically be added to replenish the reaction medium.
[0210] FIG. 2 shows another configuration, similar to FIG. 1, but
includes provision for separating unreacted carbon monoxide and
epoxide (e.g., ethylene oxide) (6) between the carbonylation
reactor (3) and the thermolysis reactor (8) by means of a
condensation step (5) using processing equipment well known to
those skilled in the art. For this case, the reaction of carbon
monoxide (1) and ethylene oxide (2) in the carbonylation reactor
(3) does not necessarily go to the complete reaction of ethylene
oxide. Condensed beta lactone (e.g., beta propiolactone) (7) is fed
directly to the thermolysis reactor (8) for the conversion to
acrylic acid in a manner analogous to that explained in the
configuration of FIG. 1. As would be typical of such processes,
there would still be provision for the purging of light gaseous
products (12), the separation of a crude acrylic acid (13) for
further purification to the required specification and the purging
of heavy byproducts and spent catalyst (11).
[0211] FIGS. 1 and 2 are just illustrative but not limiting to the
depiction of possible configurations of the invention.
[0212] The benefits of this invention include the ability to
produce valued industrial products, such as acrylic acid and
acrylic esters, from carbon monoxide, a reactant that can be
derived from any number of feedstocks, including natural gas, oil,
coal, biomass or waste products, in an efficient manner without the
potential for personal or environmental harm associated with
previous efforts to utilize this overall route.
OTHER EMBODIMENTS
[0213] The foregoing has been a description of certain non-limiting
embodiments of the invention. Accordingly, it is to be understood
that the embodiments of the invention herein described are merely
illustrative of the application of the principles of the invention.
Reference herein to details of the illustrated embodiments is not
intended to limit the scope of the claims, which themselves recite
those features regarded as essential to the invention.
* * * * *