Natural-killer/t-cell Lymphoma (nktcl) Susceptibility Prediction, Diagnosis And Therapy

Abstract

Natural-Killer T-Cell Lymphoma (NKTCL) susceptibility prediction, diagnosis and therapy. The invention relates to a method for predicting Natural Killer T-cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject comprising testing for JAK mutations. The invention also relates to a method of screening for candidate agents capable of treating NKTCL using a cell line comprising at least one JAK mutation. The invention includes an NKTCL animal model comprising at least one JAK mutation. The invention also includes JAK inhibitors for treating NKTCL.

Description

FIELD OF THE INVENTION

[0001] The present invention relates to cancer therapy and/or diagnosis. In particular, it relates to Natural-Killer/T-Cell Lymphoma (NKTCL) therapy and/or diagnosis.

BACKGROUND OF THE INVENTION

[0002] Natural killer (NK)-cell lymphoma is a type of non-Hodgkin lymphoma (NHL). Most NHLs (90%) are of B-cell origin. NK-cell lymphomas do not arise from B-cells. However, controversy still exists over the normal cell from which NK-cell lymphomas arise. In particular, whether NK-cell lymphoma represents the presence of a true NK cell or merely the presence of a T cell with abnormal cell markers is under debate. In the absence of unequivocal proof of the exact lineage of NK-cell lymphoma, many investigators prefer to use the term NK/T-cell lymphoma (NKTCL) when classifying this condition.

[0003] Natural-killer T-cell lymphoma (NKTCL) is particularly prevalent in Asian countries and some parts of Latin America. It accounts for up to half of all mature T cell lymphoma cases in Asia (1). However, compared to the more common B cell lymphomas, very little is known about its molecular characteristics and pathogenesis. There has been little progress in basic science and clinical research in this subtype of lymphoma, which continues to constitute a major challenge in managing these patients as there is currently no accepted standard first-line treatment for NKTCL. Despite multi-agent chemotherapy and involved-field radiotherapy, the 5-year overall survival is approximately 9% for non-nasal NKTCL and 42% for nasal NKTCL (2, 3).

[0004] Compared to B cell lymphomas which are relatively more common, very little is known about the molecular characteristics and pathogenesis of NKTCLs. This may be in part due to relative rarity in the West and difficulty in obtaining adequate biopsy. Treatment of NKTCLs with conventional chemotherapy has thus far yielded poor results and the outcome is almost always fatal for patients with stage III or IV disease.

[0005] It is desirable to identify novel genetic aberrations and potential treatment targets in NKTCL, as well as potential therapeutic agents for NKTCL.

SUMMARY OF THE INVENTION

[0006] The present invention relates to cancer therapy and/or diagnosis, in particular Natural-Killer/T-Cell Lymphoma (NKTCL) therapy and/or diagnosis.

[0007] According to a first aspect, the present invention relates to a method for predicting Natural Killer T-Cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject, comprising testing for the genotype of said subject for at least one JAK gene, wherein the presence of a mutant JAK gene indicates that a subject is at risk of developing and/or has NKTCL.

[0008] The invention also relates to a method for predicting Natural Killer T-Cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject, comprising testing for whether said subject expresses a wildtype or mutant JAK protein, wherein expression of a mutant JAK protein indicates that the subject is at risk of developing and/or has NKTCL.

[0009] According to a second aspect, the invention relates to a method for screening for an agent capable of treating NKTCL, comprising: [0010] (i) providing a NKTCL cell line comprising at least one mutant JAK gene; [0011] (ii) contacting the NKTCL cell line with the agent; and [0012] (iii) determining the effect of the agent on the mammalian NKTCL cell line; [0013] wherein the ability of the agent to reduce the viability, growth and/or multiplication and/or increase apoptosis of the NKTCL cell line is indicative of the ability of the agent to treat NKTCL.

[0014] According to a third aspect, the invention relates to a method for screening for an agent capable of reducing the activity of at least one of JAK protein, comprising: [0015] (i) providing a NKTCL cell line carrying a mutant JAK gene; [0016] (ii) contacting the NKTCL cell line with the agent; and [0017] (iii) determining the effect of the agent on the NKTCL cell line; [0018] wherein the ability of the agent to reduce the viability, growth and/or multiplication and/or increase apoptosis of is indicative of the ability of the candidate agent to reduce the activity of at least one JAK protein.

[0019] According to a fourth aspect, there is provided an NKTCL animal model comprising at least one mutant JAK gene.

[0020] According to a fifth aspect, the invention relates to a method of treating Natural Killer T-Cell Lymphoma (NKTCL) comprising administering a JAK inhibitor to a subject.

[0021] The invention also includes use of a JAK inhibitor in the preparation of a medicament for the treatment of Natural Killer T-Cell Lymphoma (NKTCL).

[0022] The invention further includes a JAK inhibitor for use in treating Natural Killer T-Cell Lymphoma (NKTCL).

BRIEF DESCRIPTION OF THE FIGURES

[0023] FIG. 1 shows High-resolution melt (HRM) and Sanger sequencing data leading to the identification of JAK3 A572V and A573V mutations in NKTCL samples. FIG. 1. (a) shows the location of the A572V and A573V mutation on the JH2 pseudokinase domain of the JAK3 gene. High-resolution melt (HRM) and Sanger sequencing data used to validate JAK3 mutations are shown in FIG. 1(b) through (h). In particular: FIG. 1(b) shows the percentage of the JAK3 A572V and A573V mutations in the pie chart (n=65). FIG. 1(c) shows HRM difference plots (in replicates) normalized to the wild-type sample for three genotypes: wild-type JAK3, heterozygous JAK3 (c.1715C>T, p.Ala572Val) and homozygous JAK3 (c.1715C>T, p.Ala572Val). FIG. 1(d) shows representative HRM difference curves of an Formalin-Fixed Paraffin-Embedded (FFPE) NKTCL sample which was sequenced and confirmed as heterozygous JAK3 (c.1718C>T, p.Ala573Val) mutation. Notably, HRM difference plots for sample with either JAK3 A572V or A573V mutation were similar due to the same C>T conversion. Representative sequencing chromatograms are also shown in FIG. 1 (e) for the JAK3 wild-type allele, FIG. 1(f) for the A572V heterozygous mutant, FIG. 1(g) for the A573V heterozygous mutant, and FIG. 1(h) for the A572V homozygous mutant.

[0024] FIG. 2 shows data demonstrating the effect of IL-2 on JAK3 and STAT5 phosphorylation and CP-690,550 treatment on NKTCL cell lines. FIG. 2 (a) shows immunoblotting results for NK-S1 (JAK-mutant) and KHYG-1 (wild-type) cells which were cultured with or without recombinant human IL-2 (200 IU/ml), harvested at 48 h, and assayed for JAK3 and STAT5 phosphorylation by immunoblotting. NK-S1, KHYG-1 and K562 (control) cell lines were treated with the pan-JAK inhibitor CP-690,550 and the results of evaluation are shown in FIG. 2(b) through 2(d). FIG. 2(b) shows STAT5 phosphorylation in the samples evaluated by immunoblotting at 48 h. FIG. 2(c) shows cell viability analyzed by MTS assay at 72 h. FIG. 2(d) shows drug-induced apoptosis at 72 h evaluated by Annexin V-FITC staining and analyzed by flow cytometry. Experiments were repeated at least three times. Results in c and d represent the average of triplicates.+-.s.e.m. * Indicates p<0.05 by paired Student's t-test.

[0025] FIG. 3 provides data showing Cytokine independent growth of the mutant NKTCL cell line, NK-S1. In particular, NK-S1 (JAK3 mutant) and KHYG-1 (JAK3 wild-type) were cultured with or without recombinant human IL-2 (0 to 200 IU/ml). Cell viability data is shown in FIG. 3(a) for NK-S1 and in FIG. 3(b) for KHYG-1. Cell viability was monitored daily with MTS assay for seven days and cell growth was expressed as absorbance at 490 nm minus the reference at 650 nm. Results in a and b represent the average of triplicates.+-.s.d.

[0026] FIG. 4 shows data demonstrating that JAK3 A572V mutation causes constitutive JAK3 activity and IL-2 independent proliferation of NKTCL cells. FIG. 4A shows data for NK-S1 cells which were treated with 100 nM JAK3 siRNA (si-JAK3) or control siRNA (si-Ctrl) for 24 h prior and subjected to proliferation assays up to 72 h (Right panel). In parallel, these cells were harvested and protein extracts were subjected to Western blotting with antibodies against phosphorylated JAK3 (pJAK3), phosphorylated. STAT5 (pSTAT5), JAK3, STAT5, or .beta.-actin as a normalization control. FIG. 4B shows data for KHYG-1 cells which were transiently transfected with wild-type JAK3 (JAK3 WT) or mutated JAK3 expression vectors (i.e. JAK3 A572V). The relative pJAK3, pSTAT5, JAK3 and STAT5 levels in these cells were detected by Western blotting (upper panel), and proliferation assays using these cells were performed for 48 h with or without IL-2 (lower panel). All results are expressed as mean SEM of three independent experiments. *, p<0.05 compared with Vehicle control (Vehicle).

DEFINITIONS

[0027] As used in the present specification, the term "inhibitor" refers to any substance which is able to reduce the activity of a protein, for example a JAK inhibitor is able to reduce the activity of a JAK protein. In particular, a JAK3 inhibitor is able to reduce the activity of a JAK3 protein. Reducing the activity of a protein may be direct or indirect--for example, by interfering with the expression of the protein or the mechanism by which the protein functions in a biological context. For example, the JAK3 kinase may require binding of a molecule of ATP to an ATP-binding site, so by specifically binding to and blocking the ATP-binding site, the activity of the JAK3 kinase is reduced. The activity of the JAK protein may also require the activity of another protein, such as a cytokine receptor, so interference with the activity of this protein may also reduce the activity of the JAK protein. Alternatively, fewer JAK3 kinase proteins may be expressed by interfering with gene expression at the relevant nucleic acid domain, such as the translation of the corresponding mRNA.

[0028] NKTCL refers to NK/T cell lymphoma in accordance with WHO classification (6). The terms "Natural Killer T-Cell Lymphoma," NKTCL and "NK/T-cell lymphoma" are used interchangeably to refer to a type of non-Hodgkin lymphoma (NHL) that is not of B-cell origin. NKTCL has the classic morphology of tumor necrosis, angiocentricity as well as the appropriate immunophenotype, in particular, presence of CD56, cytoplasmic CD3 as well as near universal presence of EBER. NK/T cell lymphoma differs from Adult T cell Leukemia/Lymphoma, which is a disease of the T cell lineage and associated with HTLV-I infection.

[0029] The term "treating" includes alleviating, preventing and/or eliminating one or more symptoms associated with a disease, for example Natural killer/T-cell Lymphoma (NKTCL)

DETAILED DESCRIPTION OF THE INVENTION

[0030] The present invention relates to cancer therapy and/or diagnosis, in particular Natural-Killer/T-Cell Lymphoma (NKTCL) therapy and/or diagnosis.

[0031] According to a first aspect, there is provided a method for predicting Natural Killer T-Cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject, comprising testing for the genotype of said subject for at least one JAK gene wherein the presence of a mutant JAK gene indicates that a subject is at risk of developing and/or has NKTCL. The presence of either a heterozygous or homozygous mutant JAK gene indicates that the subject is at risk of developing and/or has NKTCL.

[0032] Any one or a combination of any of the JAK genes may be tested. The JAK gene tested may be selected from the group consisting of JAK1, JAK2, JAK3 and TYK2. For example, the JAK3 and/or JAK1 genes may be tested. In general, SEQ ID NO: 1 indicates a wildtype JAK3 gene. In one example, the presence of a mutant JAK3 gene comprising a substitution of C with T at nucleotide 15792 and/or a substitution of C with T at nucleotide 15795 of SEQ ID NO: 1 indicates that a subject is at risk of developing and/or has NKTCL.

[0033] In general, SEQ ID NO: 3 indicates a wildtype JAK1 gene. In another example, the presence of a mutant JAK1 gene comprises a substitution of T with G at nucleotide 124823 of SEQ ID NO: 3 indicates that a subject is susceptible and/or has NKTCL. The presence of both mutant JAK1 and JAK3 genes also indicate that a subject is at risk of developing and/or has NKTCL.

[0034] The method may be performed on an isolated cell sample from the subject. The isolated cell sample may be from a blood and/or tumour sample. Accordingly, the method may further comprise providing an isolated cell sample from the subject for testing. The method may further comprise isolating nucleic acid molecules from the subject, blood sample and/or isolated cell sample for said testing. The isolated nucleic acid molecules may comprise genomic DNA or mRNA. In particular, the testing may be performed on genomic DNA, mRNA and/or cDNA.

[0035] Any suitable technique may be employed for testing. For example, testing may be by sequence analysis, restriction fragment length polymorphism analysis, hybridization, polymerase chain reaction (PCR) and/or reverse transcription PCR. In particular, techniques such as Sanger sequencing and High resolution melt may be used for testing.

[0036] In another aspect of the invention, there is provided a method for predicting Natural Killer T-Cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject, comprising testing for whether said subject expresses a wildtype or mutant JAK protein, wherein expression of a mutant JAK protein indicates that the subject is at risk of developing and/or has NKTCL.

[0037] Any one or a combination of any of the JAK proteins may be tested. The JAK protein tested may be selected from the group consisting of JAK1, JAK2, JAK3 and TYK2. For example, the JAK3 and/or JAK1 proteins may be tested. In general, SEQ ID NO: 2 indicates a wildtype JAK3 protein. In one example, the presence of a mutant JAK3 gene comprising a substitution of A with V at amino acid 572 and/or a substitution of A with V at amino acid 573 of SEQ ID NO: 2 indicates that a subject is at risk of developing and/or has NKTCL.

[0038] In general, SEQ ID NO: 4 indicates a wildtype JAK1 protein. In another example, the presence of a mutant JAK1 protein comprising a substitution of Y with D at amino acid 652 of SEQ ID NO: 4 indicates a subject at risk of developing and/or has NKTCL. The presence of both mutant JAK3 and JAK1 proteins also indicate a subject at risk of developing and/or has NKTCL.

[0039] The method may be performed on an isolated blood and/or cell sample from the subject. The isolated cell sample may be from a tumour. Accordingly, the method may further comprise providing an isolated blood and/or cell sample from the subject for testing. The method may further comprise isolating proteins molecules from the subject, blood sample and/or isolated cell sample for said testing.

[0040] Any suitable method may be used to detect whether the relevant wildtype and/or mutant JAK protein is expressed. For example, testing may be by protein sequencing and/or antibody detection. In particular, Enzyme-linked immunosorbent assay (ELISA) using at least one antibody with specificity for the relevant wildtype and/or mutant JAK protein may be used.

[0041] In a second aspect of the invention, there is provided a method for screening for an agent capable of treating NKTCL, comprising: [0042] (a) providing a NKTCL cell line comprising at least one mutant JAK gene; [0043] (b) contacting the NKTCL cell line with the agent; and [0044] (c) determining the effect of the agent on the NKTCL cell line; wherein the ability of the agent to reduce the viability, growth and/or multiplication and/or increase apoptosis of the NKTCL cell line may be indicative of the ability of the agent to treat NKTCL.

[0045] In a third aspect of the invention, there is provided a method for screening for an agent capable of reducing the activity of at least one JAK protein, comprising: [0046] (i) providing a NKTCL cell line carrying at least one mutant JAK gene [0047] (ii) contacting the NKTCL cell line with the agent; and [0048] (iii) determining the effect of the agent on the NKTCL cell line; [0049] wherein the ability of the agent to reduce the viability, growth and/or multiplication and/or increase apoptosis of cell line is indicative of the ability of the candidate agent to reduce the activity of at least one JAK protein.

[0050] The NKTCL cell line may carry any one or a combination of any of mutant JAK1, JAK2, JAK3 or TYK2 genes. For example, the NKTCL cell line may carry a mutant JAK3 gene and/or a mutant JAK1 gene. In particular, the mammalian NKTCL cell line may carry at least one of the following mutations: [0051] (i) a substitution of C with T at nucleotide 15792 of SEQ ID NO:1 (in the JAK3 gene); [0052] (ii) a substitution of C with T at nucleotide 15795 of SEQ ID NO:1 (in the JAK3 gene); and [0053] (iii) a substitution of T with G at nucleotide 124823 of SEQ ID NO:3 (in the JAK1 gene).

[0054] According to a fourth aspect, the invention also relates to an NKTCL animal model comprising at least one mutant JAK gene. For example, the NKTCL animal model may comprise at least one mutation selected from the group consisting of mutant JAK1, JAK2, JAK3 and TYK2 genes. In particular, the NKTCL animal model comprises a mutant JAK3 gene and/or a mutant JAK1 gene. More in particular, the NKTCL animal model comprises at least one of the following mutations: [0055] (i) a substitution of C with T at nucleotide 15792 of SEQ ID NO: 1; [0056] (ii) a substitution of C with T at nucleotide 15795 of SEQ ID NO: 1; or [0057] (iii) a substitution of T with G at nucleotide 124823 of SEQ ID NO: 3.

[0058] The NKTCL animal model may also be useful for screening candidate agents capable of treating NKTCL.

[0059] According to a fifth aspect, there is provided a method of treating Natural Killer T-Cell Lymphoma (NKTCL) comprising administering at least one JAK inhibitor to a subject. Any suitable JAK inhibitor may be used. In another aspect of the invention, there is provided a use of at least one JAK inhibitor for the preparation of a medicament for the treatment of Natural Killer T-Cell Lymphoma (NKTCL). In another aspect of the invention, there is provided a JAK inhibitor for use in treating Natural Killer T-Cell Lymphoma (NKTCL). The JAK inhibitor may able to reduce the activity of JAK3 protein.

[0060] For example, the JAK inhibitor may inhibit at least one of JAK1, JAK2, JAK3 and/or TYK2. Accordingly, the inhibitor may be a pan-JAK inhibitor. In one particular example, the JAK inhibitor may inhibit JAK3 and/or JAK1. More in particular, the JAK inhibitor may inhibit JAK3 or the JAK inhibitor may also inhibit JAK1.

[0061] In a first particular example, the JAK inhibitor may comprise 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piper- idin-1-yl]-3-oxopropanenitrile (also known as CP-690,550). In a second particular example, may comprise (E)-2-cyano-3-(4-nitrophenyl)-N-((R)-1-phenylethyl)acrylamide (also known as WP-1034).

[0062] The subject to whom the JAK inhibitor is administered may comprise a mammal. The subject may comprise a human. The subject may carry a homozygous or heterozygous mutation in at least one of the JAK genes/JAK proteins. For example, the subject may carry a homozygous or heterozygous mutation in JAK1/JAK1, JAK2/JAK2, JAK3/JAK3 and/or TYK2/TYK2. In particular, the subject may carry a homozygous or heterozygous mutation in JAK1/JAK1 and/or JAK3/JAK3. More in particular, the subject may have at least one mutation selected from the group consisting of JAK3-A572V, JAK3-A573V and JAK1-Y652D. However, the subject may also comprise a homozygous wildtype phenotype. The subject may have increased expression of any one of the JAK genes, its transcriptional and/or translational products (proteins), whether it carries a homozygous wildtype, heterozygous or homozygous mutant gene.

[0063] CP-690,550 is a JAK inhibitor. It is known as Tofacitinib, Tasocitinib, or by the trade name XELJANZ. Its chemical name is 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piper- idin-1-yl]-3-oxopropanenitrile and its structural formula is:

##STR00001##

[0064] WP-1034 has been described as having proapoptotic and antileukemic activity in Acute Myeloid Leukemia (Faderl et al., Anticancer Research 25: 1841-1850 (2005)) (8). It is a member of the tyrphostin family of tyrosine kinase inhibitors, which has been predominantly studied as an inhibitor of the Jak-Stat pathway. Its chemical structure and name are as follows:

##STR00002##

WP1034-(E)-2-cyano-3-(4-nitrophenyl)-N-((R)-1-phenylethyl)acrylamide

[0065] Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention.

Examples

[0066] The molecular pathogenesis of Natural-killer/T-cell lymphoma (NKTCL) is not well understood. Gene mutations causing NK/T-cell lymphoma have not been fully identified. In this study, Janus kinase 3 (JAK3) somatic activating mutations (A572V and A573V) were identified through whole-exome sequencing in two out of four NKTCL patients. Further validation of the prevalence of JAK3 mutations was determined by Sanger sequencing and High Resolution Melt (HRM) analysis in an additional 61 cases. In total, 23 of 65 (35.4%) cases harbored JAK3 mutations. Mutant NKTCL cell line harbouring JAK3 A572V mutation showed IL-2 independent growth and constitutive JAK3 and STAT5 phosphorylation suggesting its oncogenic role. Functional characterization of the JAK3 mutations support its involvement in cytokine-independent JAK/STAT constitutive activation leading to increased cell growth. These mutations may play a significant role in the pathogenesis of NKTCL. Moreover, treatment of both JAK3-mutant and wild-type NKTCL cell lines with a novel pan-JAK inhibitor, CP-690,550, resulted in dose dependent reduction of phosphorylated STAT5, reduced cell viability and increased apoptosis. CP-690,550 is a pan-JAK inhibitor, having an inhibitory effect on not just JAK3 but also JAK1. This may be important because in their function within the JAK-STAT signalling pathway system, JAK1 and JAK3 cross-talk and there may be some compensatory upregulation of one in response to inhibition of the other. For example, if JAK3 is inhibited, JAK1 may be upregulated so as to compensate for the reduced activity of JAK3, and this may preserve JAK-STAT signalling. The reverse may also apply. To take the example further, treatment of NKTCL using a pan-JAK inhibitor that is able to reduce the activity of not just JAK1 but JAK3 as well may be especially effective at inhibiting JAK-STAT signalling.

[0067] Hence, targeting the deregulated JAK/STAT pathway could be a promising therapy for NKTCL patients. These findings have important implications for the management of NKTCL patients.

Materials and Methods

Tissue Samples

[0068] Matched fresh-frozen tissue and peripheral blood samples were obtained from four consented patients with NKTCL. The inventors further identified paraffin-embedded tissue blocks from 61 patients with NKTCL for validation. The diagnosis of NKTCL was made according to the 2008 World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues (6). All samples were centrally reviewed by Singhealth hematopathologists. This study was approved by the SingHealth Centralized Institutional Review Board, Singapore.

DNA Isolation

[0069] DNA of frozen tissue and paired blood samples was isolated using a DNeasy Blood and Tissue Mini Kit (Qiagen) and a QIAmp DNA Blood Midi Kit (Qiagen), respectively, according to manufacturer's instruction. For Formalin-Fixed Paraffin-Embedded (FFPE) samples, genomic DNA was extracted from one or two 10-.mu.M slices from each sample, paraffin was removed by xylene, tissues were washed twice with 100% ethanol, followed by overnight proteinase K digestion. DNA was then extracted using a DNeasy Blood and Tissue Mini Kit (Qiagen).

Detection of Somatic Mutations in Janus Kinases

[0070] Genomic DNA of extracted from each sample was whole genome amplified with REPLI-g WGA Midi Kit (Qiagen). The coding exonic sequences of JAK1, JAK2, JAK3 and Tyk2 were sequenced by Sanger sequencing to detect mutations. Somatic origin of the mutations were confirmed when the mutations were only detected in the tumor but not in the paired blood sample.

[0071] The mutation sequence information is provided below in Table 1 and in the accompanying genomic DNA, protein and cDNA sequence listings (SEQ ID No.:1 to SEQ ID No.: 6), with the following sequence identifiers: [0072] SEQ ID NO: 1--JAK3 Wildtype genomic DNA [0073] SEQ ID NO: 2--JAK3 Wildtype amino acid sequence [0074] SEQ ID NO: 3--JAK1 Wildtype genomic DNA [0075] SEQ ID NO: 4--JAK3 Wildtype amino acid sequence [0076] SEQ ID NO: 5--JAK3 Wildtype cDNA [0077] SEQ ID NO: 6--JAK1 Wildtype cDNA

TABLE-US-00001 [0077] TABLE 1 JAK1 and JAK3 Mutation Information Protein ORF.sup.1 cDNA Gene JAK1 Y652D.sup.6 T1954G T2203G.sup.2 T124823G.sup.4 JAK3 A572V.sup.7 C1715T C1815T.sup.3 C15792T.sup.5 JAK3 A573V.sup.7 C1718T C1818T.sup.3 C15795T.sup.5 Notes on Table 1: .sup.1ORF: Open reading frame, coding region, starts from ATG .sup.2NCBI Reference Sequence: NM_002227.2 (SEQ ID NO: 6) .sup.3NCBI Reference Sequence: NM_000215.3 (SEQ ID NO: 5) .sup.4NCBI Reference Sequence: NG_023402.1 (SEQ ID NO: 3) .sup.5NCBI Reference Sequence: NG_007273.1 (SEQ ID NO: 1) .sup.6NCBI Reference Sequence: NP_002218.2 (SEQ ID NO: 4) .sup.7GenBank: AAC50950.1 (SEQ ID NO: 2)

Mutation Validation Using High-Resolution Melt (HRM) and Bi-Directional Sanger Sequence Analysis

[0078] High-resolution melt (HRM) and Sanger sequencing were used to confirm the JAK1 and JAK3 mutations and validate their prevalence in the NKTCL patient population. Combining both methods will greatly improve the precision of mutation detection in FFPE samples. The JAK2 V617F mutation was also sequenced with both methods. The sequences of primer sets used for validation are listed in Table 2 (see below) and included in the accompanying sequence listings under the corresponding identifiers.

TABLE-US-00002 TABLE 2 Validation Primer Sets Used for Sanger Sequencing and HRM Analyses ##STR00003##

[0079] HRM Curve Analysis was used to discern the presence of the point mutations. SsoFast.TM. EvaGreen Supermix.RTM. (Bio Rad, Cat. No. 172-5200) was used for amplification of target DNA fragments encompassing the relevant mutations from genomic DNA samples. HRM primers were used at a final concentration of 600 nM and reactions were performed with BioRad CFX96 Real time PCR Detection System in replicates. The cycling and melting conditions were as follows: one cycle of 98.degree. C. for 2 min; 39 cycles of 98.degree. C. for 5 sec, 58.degree. C. for 10 sec; one cycle of 95.degree. C. for 30 min and a melt from 72.degree. C. to 95.degree. C. rising at 0.2.degree. C./sec. The HRM curves were analyzed with the Biorad Precision Melt Analysis.TM. software. HRM difference curves deviating from the wild-type curve were considered to be harbouring a mutation.

[0080] For Sanger sequencing, PCR was performed with Invitrogen Platinum Taq Polymerase (Cat. No. 10966-083) and cycled at 95.degree. C. for 10 min; 39 cycles of 95.degree. C. for 30 sec; 60.degree. C. for 30 sec, 72.degree. C. for 1 minute and a final extension of 72.degree. C. for 10 min. Sequencing PCR was performed with ABI BigDye Terminator v3.1 (Cat. No. 4337457) and cycled at 96.degree. C. for 1 min; 29 cycles of 96.degree. C. for 10 sec; 50.degree. C. for 5 sec & 60.degree. C. for 4 min. The resulting products were run on ABI 3730 DNA Analyzer.

Cell Lines, Cell Viability and Apoptosis Assays

[0081] NK-S1 is a cell line established from a previously described NKTCL xenograft (7). The xenograft was derived from metastatic tumor of the testis from the same patient found to have both JAK1 (Y652D) and JAK3 (A572V) mutations. NK-S1 was cultured for more than 60 passages in DMEM medium supplemented with antibiotics, heat-inactivated FBS (10%) and equine serum (ES) (10%). Phenotypic analysis showed surface CD3.sup.-CD56.sup.+, and Granzyme B.sup.+ by intracellular staining. NK-S1 NKTCL cell line was sequenced and confirmed to carry homozygous mutation for JAK3 A572V, as well as a mutation on JAK1 codon 652. KHYG-1 is an IL-2 dependent aggressive NK leukemia cell line obtained from the Japanese Collection of Research Bioresources, and it was cultured in RPMI medium supplemented with antibiotics, heat-inactivated FBS (10%), ES (10%) and 200 IU/ml of recombinant human IL-2 (Proleukin, Novartis).sup.7. KHYG-1 was sequenced and found to be wild-type for JAK3 codon 572 and 573, and JAK1 codon 652 and 658. K562 (CCL-234, ATCC) is a chronic myeloid leukemia (CML) cell line positive for the BCR-ABL fusion gene.

[0082] To study the sensitivity of NKTCL cell lines to CP-690,550 (Selleck Chemical, Cat. No. S5001), a pan-JAK inhibitor, cells were seeded at 2.times.10.sup.4 cells/100 .mu.L/well in 96-well plates and treated with CP-690,550 at various concentrations or with vehicle control. The viability was evaluated by MTS assay using a CellTiter 96.RTM. AQueous Non-Radioactive Cell Proliferation Assay Kit (Promega), absorbance was read at both 490 nm and 650 nm (as reference). The extent of drug-induced apoptosis was evaluated by Annexin V-FITC (BD Biosciences) staining. Acquisition of the data was performed on a FACSCalibur flow cytometer (BD Biosciences).

Immunoblotting

[0083] Cells were harvested at indicated time intervals after incubation with or without recombinant human IL-2 (Proleukin, Novartis), or in the presence or absence of CP-690,550. Cells were washed with ice-cold phosphate buffer saline (PBS) and lysed in 50 .mu.l of ice-cold RIPA buffer [25 mM Tris-HCL, pH 7.6, 150 mM NaCl, 1% Nonidet P-40, 1% sodium deoxycholate, 0.1% SDS, 1.times. Phosphatase Inhibitor (Cat. No. 78420, Thermo Fisher Scientific), 1.times. Protease Inhibitor (Cat. No. 12978000, Roche Diagnostics) and 1 mM Sodium Orthovanadate]. Thereafter, cell lysates were sonicated twice on ice for 10 seconds, 20 Amp and agitated on ice for another 15 minutes. After centrifugation at 14,000 g for 15 minutes at 4.degree. C., supernatants were removed and protein concentration was determined using Bio-Rad Protein assay (Cat. No. 500-0006, Bio-Rad Laboratories). Protein samples were separated on a 5% stacking and 8% resolving SDS-polyacrylamide gel using Mini-PROTEAN Tetra Electrophoresis System (Cat. No. 165-8006, Bio-Rad Laboratories) and transferred onto 0.45 .mu.M nitrocellulose membrane (Cat No. 162-0115, Bio-Rad Laboratories) using Mini Trans-blot Electrophoretic Transfer Cell (Cat. No. 170-3930EDU, Bio-Rad Laboratories) at 100V for 120 minutes. Membranes were blocked with 5% Milk in PBST, followed by overnight incubation of rabbit anti-phospho-jak1 (Tyr 1022/1023) (Cat. No. 3331, Cell Signaling), rabbit anti-phospho-JAK3 (Tyr 980/981) (D44E3) (Cat. No. 5031, Cell Signaling), mouse anti-Phospho-Stat5 (Tyr 694) (Cat No. 9356, Cell Signaling) and rabbit anti-phospho-stat3 (Tyr 705) (D3A7) (Cat. No. 9145, Cell Signaling) in 5% BSA and 5 mM sodium orthovanadate in PBST. were visualized using enhanced chemiluminescence (ECL) (Cat. No. 3407, Thermo Fisher Scientific, and Cat. No. RPN 2132, Amersham). Antibody for Jak1 (6G4) (Cat. No. 3344, Cell Signaling), Jak3 (Cat. No. 3775, Cell Signaling), Stat5 (Cat. No. 9363, Cell Signaling) and .beta.-actin (Cat. No. A1978, Sigma) were used to detect unphosphorylated proteins or as a loading control. All antibodies were used at the recommended dilutions.

Results

[0084] Sanger sequencing was used to sequence the exonic regions of JAK1, JAK2, JAK3 and Tyk2 in fresh frozen tumor and blood specimens from four patients with Extra nodal NKTCL. Two JAK3 mutations, A572V (p.Ala572Val, c.1715C>T) and A573V (p.Ala573Val, c.1718C>T), and a novel JAK1 mutation, Y652D (p.Tyr652Asp, c.1954T>G) were identified. Interestingly, JAK3 A572V and JAK1 Y652D mutations were found on the same sample. Both JAK3 mutations are both located at exon 12 on the JH2 pseudokinase domain (FIG. 1a), which is known to have an auto-inhibitory effect on the JH1 kinase domain. All three missense mutations identified in JAK1 and JAK3 were confirmed to be somatic in origin and predicted by Polyphen to be probably damaging.

[0085] Mutations identified were validated in FFPE samples of additional 61 patients with ENKTCL to confirm their prevalence. From this validation study, another 21 patients with JAK3 mutations were identified by Sanger sequencing. In total, out of 65 NKTCL patients 23 patients (35.4%) were found with JAK3 mutations (FIG. 1b). High Resolution Melt (HRM) analysis was performed on 40 FFPE samples and 14 JAK3 mutants were detected (35%). Amongst the 23 patients with JAK3 mutations, there were 17 heterozygous A572V, two homozygous A572V, two heterozygous A573V mutants, one homozygous A573V mutant and one patient had both an A572V and A573V heterozygous mutations (FIG. 1c-h). No additional JAK1 Y652D mutant was found. In addition, no patients were found with the JAK2 V617F (p.Val617Phe or c.1849G>T) mutation, which is recently found to be present in a large proportion of patients with classic BCR/ABL-negative chronic myeloproliferative disorders and several patients with other clonal hematological cancers such as myelodysplastic syndrome and acute myeloid leukemia.

Discussion

JAK3.sup.A572V Activating Mutations Confer Cytokine Independent Growth

[0086] IL-2 is an essential cytokine required for the proliferation and activation of NK cells (4). JAK1 and JAK3 mediate IL-2 receptor signaling through phosphorylation of STAT transcription factors (5). In line with the functional importance of the activating JAK3 mutations identified, we tested if JAK3 mutations could confer IL-2 independent growth to the NKTCL cell line (NK-S1) that harbors a homozygous JAK3.sup.A572V mutation. JAK-mutant (NK-S1) cells showed IL-2 independent growth (FIG. 3) and constitutive phosphorylation of both JAK3 and STAT5 (FIG. 2a). In contrast, JAK3-wild type KHYG-1 cells were clearly IL-2 dependent (FIGS. 3 and 2a). Importantly, NK-S1 cells treated with JAK3 siRNAs exhibited a significant reduction in cell proliferation and also decreased autophosphorylation of JAK3 and STAT5, compared with cells treated with control siRNAs (FIG. 4A). Reciprocally, KHYG-1 cells transiently over-expressing a mutated JAK3 (JAK3.sup.A572V) cDNA demonstrated IL-2 independent proliferation and autophosphorylation of JAK3 and STAT5 (FIG. 4B). These results indicate that the JAK3 activating mutations are gain of function alleles and contribute to the constitutive activity of the JAK/STAT pathway in an IL-2 independent manner.

[0087] This study demonstrated that JAK mutations confers cytokine independent growth in a NKTCL cell line established from xenograft derived from patient sample harboring both JAK3 A572V and JAK1 Y652D mutation. NK-S1 showed IL-2 independent growth (FIG. 3), constitutive JAK3 and STAT5 phosphorylation (FIG. 2a) in contrast to the wild-type KHYG-1, which was tested not to carry JAK1 and JAK3 mutations identified (FIG. 2a).

Effects of CP-690,550 on NKTCL Cell Lines

[0088] The ability of CP-690,550, a pan-JAK inhibitor, to suppress the JAK-STAT pathway, was evaluated. Because activated JAK proteins directly phosphorylate STAT proteins, the JAK-mutated cell line (NK-S1) and the wild-type NKTCL cell line (KHYG-1) were treated with increasing concentrations of CP-690,550 and analyzed the pSTAT5 by immunoblotting (FIG. 2b). Both the NK-S1 and KHYG-1 cell lines showed a dose-dependent reduction of pSTAT5 (FIG. 2a) and reduced cell viability (FIG. 2b) upon treatment with the inhibitor. CP-690,550 did not inhibit pSTAT5 in the control K562 cell lines since its STAT5 phosphorylation is independent of activated JAK3 (FIG. 2b). The reduced viability of NK-S1 correlated with increased apoptosis as shown by Annexin V staining (FIG. 2c).

[0089] In summary, through exonic sequencing of Janus kinases (JAK) of Natural-killer/T-cell lymphoma (NKTCL) JAK3 A572 and A573V and JAK1 Y652D mutations have been identified in NKTCL patients, and the prevalence of JAK3 mutations was validated to be 35.4%. A mutant NKTCL cell line harboring JAK3 A572V mutation showed IL-2 independent growth and constitutive JAK3 and STAT5 phosphorylation suggesting an oncogenic role for mutations in the corresponding nucleic acid domain. In vitro study suggests that pan-Jak inhibitor could be a new therapeutic agent for NKTCL patients. CP-690,550, a pan-JAK-inhibitor, was shown to reduce cell viability and cause apoptosis in both JAK3 wild-type (KHYG-1) and mutant (NK-S1) cell lines. KHYG-1 is an IL-2 dependent NKTCL cell line, thus its sensitivity to pan-JAK inhibitor.

REFERENCES

[0090] 1. Kwong Y L, Anderson B O, Advani R, Kim W S, Levine A M, Lim S T. Management of T-cell and natural-killer-cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009. The lancet oncology 2009; 10(11): 1093-1101. [0091] 2. Au W Y, Ma S Y, Chim C S, Choy C, Loong F, Lie A K et al. Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years. Ann Oncol 2005; 16(2): 206-214. [0092] 3. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008; 26(25): 4124-4130. [0093] 4. Suzuki R, Handa K, Itoh K, Kumagai K. Natural killer (NK) cells as a responder to interleukin 2 (IL 2). I. Proliferative response and establishment of cloned cells. J Immunol 1983; 130(2): 981-987. [0094] 5. Lu L, Zhu J, Zheng Z, Yan M, Xu W, Sun L et al. Jak-STAT pathway is involved in the induction of TNF-beta gene during stimulation by IL-2. European journal of immunology 1998; 28(3): 805-810. [0095] 6. Campo E, Swerdlow S H, Harris N L, Pileri S, Stein H, Jaffe E S. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 2008; 117(19): 5019-5032. [0096] 7. Loong S L, Hwang J S, Lim S T, Yap S P, Tao M, Chong T W et al. An Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing. Leukemia & lymphoma 2008; 49(6): 1161-1167. [0097] 8. Faderl et al., WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). Anticancer Research 25: 1841-1850 (2005)

Sequence CWU 1

1

18128840DNAHomo sapiens 1gtattttatc tttttcagtg ctgctgcaaa ggaaattttt caaaattttt ttatgttcca 60attgtttgct gctggtgtat aaaaattcaa ttgacttttg tattgaattc aacggacttt 120ttaaacctgg taacttgctg aatttatgta ttaatttcag tagttgtctt atagattccc 180ttgggttttt gacataaaca atcatatcat cagcaaatag caacagtttt atttaccttt 240tttttattac ttattttatt ctgttttgct tgttacagaa tcttgctatg ttgcctttaa 300attcttgggc tcccatttca gcttctccag tagctgaggc tacaagcatg tatcaccatg 360cccagccaca cctgacttgt ttatttttct catatatttt tttgttttaa gacaggatct 420cgctctgttg cccagactgg agtgtaatgg tgtgatgatg gcttactgca gccttgtcct 480ccctgactca agcaatcctc agcctcccaa atagctggga caacaggtgt gagctatcac 540accctgccaa tttttaattt tttttttttt tttgagacag agtctccctc tgtcacctag 600gctggagtgc agtggcgcga tcttggctca ctgcaacctt cacctcccgg gttcaagcga 660ttctcctgcc tcagcctcct gagtagctgg gattacaggc gcgcatcacc acgcacggct 720aatttttgta tttttaccat gcctggctaa tttttgtatt tttagtagag atggggtttc 780accatgttga tcaggctggt cttgaactcc tgaccttgtg attctcccac ctcagcctcc 840caaagtgctg ggattacagg cgtgagccac catgcccagc ttttcttttc tttctttctt 900tttttttttt tttagacgga gtctcactct gtcacccagg ctggagtgca gtggcccgat 960cttggctcac tgcaagctcc gcctccctgg ttcacaccat tctcctgcct cagcctgctt 1020tttcttttct tattacagtg gctaacatca ccagaacaat gttgaataga ggtggtgaaa 1080atggacatcc ttgtcttgtt tccaatctca ggaggaagtt attcagtctt ttaccatttt 1140tgtttttgtt tttgagatgt agtctcgctc tgtcgcccag gctggagtac agtggcacta 1200tcttggctcc ctgcaacctc tgcctcctgg actcaagcca tcctcccact tcagtcttcc 1260aagtagctga gactacaggt gcacaccacc atgcctggct aatttttgta tgttttgtag 1320agacggatct caccatgttg cccaggctaa tctccaactc ctgagctcaa atgatcctcc 1380catgttgact tcccaaagtg ctcagattac aggcatgagc caccgtgcct ggccctgcct 1440cactgtactc ttaattttca tttggcaagt gaagctgagg aaatttttct gggtttaaga 1500gctatttgtc ctccattttc tctgacttct ggattcatat ccacctaact ggttggcatt 1560ttcttactgc tttctagatg ttacttatat aacgaggata ttttatccat gagttcaatt 1620ttgtttccag ttacactttg attgtatttt attctttgat tgtatttatg gacttcttgt 1680cagcagaaaa atctgggtgt ttgcatcact gacgtgcccc atttttctcg ggcaagttct 1740gggttctgtc cccagaactt ccttttttta aaaaaaatta tttatttatt tatttatttt 1800ttgatacgga gtcttgctgt gtcgcccagg ctggagtgca gttgtgcgat ctcggctcac 1860tgcaacctcc gcctcccagg ttcaagtgat tctcttgcct cagcctcctg agtagctggg 1920actgcaggcg cccgccacca cacccagctg cgttttgtat ttttagtaga gatggggttt 1980caccaggttg gcaaggccgg tctcgaactc ctaacctcag gcgatccgcc cgcctcggcc 2040tcccaaagtg ctgggattat aggcgtgagc caccgcgccc ggccagaact tccttttaga 2100gccttcacat gcccttctct ggggctgaag gtaccacttt ggtcctcacc ccaatctcct 2160cttacttatt ctcaaaatat tgcagaaacc atcacactgg aggtagcaga gacccagaaa 2220ctcactgtac ttccggaaag cagaggcttc agcctcaggc caaggatgag aacataaggt 2280tgcattcccg tctgctgaag ccacccagga agtgaaagaa aacactacaa ctaagcttct 2340gcttggcact tcctgccgca ggtcagctgt ggctccacta agctccacta agctgaggac 2400ataatctata tctctttccc ttgacccacg cggccctacc cacgccatca aatgagtctc 2460agccccccgt gtccctgaca tcctgctctt ctcaggaaca ctgtgaattc gtgaagcctc 2520caggcctttg cctgggctgt tctgcctgcc agaactgccc acactcccac attctcaggt 2580cactctctgg ctagtcccac ttgttgttgg atttcagaat caaagccacc tcctccagga 2640agccctccca gatccagtca tctctcttag cagaccggtc ccaggggcaa ctgatataat 2700tattgggcaa tagcttgttt attgccatct cccctgctgg actgtcagct cccctggaca 2760gggattgggt ctgcattgtc cccgattccc tgcacacagg ctgtgtccaa taagcctctg 2820gctgattgaa cagttaagat caacaaaata cttaccaaac cattttgtgt taagacttgt 2880gatggtgata cagagatgaa aagtcttttt tttttttttt ttgagacggg atctcactcc 2940cattgcccag gctggagtgc agtggcatga ccacagctaa ctgcagcctc aacttcctgg 3000gctcaggtga tcctcccacc tcagcctccc ctagtagctg ggactacagg cacatgccac 3060cacatccagc ttattatttt gttgttgttg tattttttgt agagacaggg tttcaccatg 3120ttgcccaggc tggtctcgaa cacctgggct caagccatcc tcctgcctga gcctcccaaa 3180gtgctgagat tacaggtgtg agccactgtt cttggccaca acttcttaaa tctattcctt 3240tttttttttt tgagacagag tattgctccg tcgcccaggc tggagtgcgg tggcacaatc 3300tcagctcact acaacctccg cctgcctcct gggttccagt gattctcctg cctcagcctc 3360ccaagtagct gggattacag gcacatgcca ccacgcccag ctaattttta tatttttagt 3420agagatgggg tttcaccatg ttggccaggc tggtctcgaa ctcctaggct caagcaatct 3480tcccacctgg gccttccaaa gtgctggaat tacagatgtg agccactgta cccggtcacc 3540acttcgtcag tctattcctg aagctctact tccggggctc tgatcctatt atcctaagaa 3600cactggccca agtctctgca tttggatgct gcccgggcct tctgcctctt ctatttataa 3660cagctcctac ttccaactct cctgtggctc cagattatgc tccaggcaaa acccaccctt 3720ctcccaaaga ccctgatccc cctgtccccc cacgatcttg cccctgttga ccgccctgca 3780gtccccttcc ccctcatctc acccctgccc ctggcctcct gactgctctt caagctgcta 3840agatcactgc cctctcaagg tctttgccca tcctgtgccc tcctcctgga gcaccctttc 3900cctggccagc tccctgtcct gcctcgggtc caagttccag tctgtgcctg tcctgacacc 3960ctggctttct ttgttgtctg cgatgatttg gctccttcat ttgctcattg tctcagcgcc 4020agatcacaag ttccaagagg ccaggccgga tccacctggt tttttagggc tgggcccagg 4080gcaccacagg cagaaatggg tcattatctc tccctgagtc ttttcttttt tttttaaacg 4140aagtcccgct ctgttgccag gctggagtgc agtggcgcca tctcgtctca ctgtaacatc 4200cgcctcctag attcaagcaa tcctcccacc tcagcctcct gagtagctag gattacaggc 4260atcaccaggc ctggctaatt ttcctgtttt tagtagagac agggtttcat catgttggcc 4320aggctggtct caaactcctg acttcaagtg atccgcccgc ctcagcctcc caaagtgctg 4380cgattacagg ccaccacgcc tggctaattt ttgtattttt agtagagacg gagtttcgcc 4440atgttggcta ggctggtctc aaactcctga cctcaagtaa tcgcccgcct cagtctccca 4500aagtgctggg atgacaggcg tgagccactg cgcccagcgt ctccctgagt cttaagggag 4560aaatacctca aagaagaact tgaccttcct ctggggcaac ttccctgctt ccctcctggg 4620caaatccagc caggtttcct tccctgggtg caaaattagt tccactgggt gcccaactca 4680cacatgctac agatgggtaa actgaggcaa taagggccgg gccagagccc cacttaacaa 4740gtgggtctag agtcggctga gcccctggtg tgacccagac ccttctctgt gctatcatca 4800gttcctttgg cttaggggtc tccagcagcc tgtctgaacg gggcggctga tgcagaggct 4860tccggaactt tctgcccctc cttgcccgcc tccccgcccc cagctcccgc agggccctga 4920ctttcggtaa atgacagtgg ctcaggaaac caaggggccc acacaggaag gagccgagtg 4980ggactttcct ctcgctgcct cccggctctg cccgcccttc gaaagtccag ggtccctgcc 5040cgctaggtaa gagctggcga tgccgcaggg ctcggcccag acactggggg aggatggtgg 5100tggcggggga tggctgggct ggggcagggt gctgccaggg caaaggctag ctcgccttcc 5160aggcctcgga ggaaagctgc gaggcagacg tgagccgaga ctcgcatcct ccgatcgctc 5220gcttctctgg gcttcggctt tgactaaggc cgggagatgc ctgccttgcg gacctggagg 5280agtcattgcg catgcgcgac gggggctgcg gggttggggg tggggaggag ggattgggaa 5340ggagggattg gggggcggag ttcccagccc ctaccctcca ggccttcccg gtccagacac 5400agggtacccg accataccag gatgcagaac gttgaggatt ataaacaggg gatgccgagg 5460cgggaggata gcttgaggcc aggagttcaa ggccagcctg ggcaacatag ccagacctcc 5520atttctacaa acatttttaa aaaaccaaaa aaactatggc gttttctggg accaaacatc 5580acctctgact tttcattttt ttttgttaca gtattacaga ataataatat tctgttaaga 5640tttttttgtt gttttggaga tgggagtctt gctatgttgt tcaggcaggt ctctaacccc 5700tggcctcaag ctatcctgct gcctcagccc cctgagtagc tgggattgca gtggggcgcc 5760actgccactg aagccttatt ttaaactcga ctggggctgg gcacagtggc tcatgccttt 5820aatcccaaca ctttgggagg ctgaggccag cggatcactg gaggtcagga gttcgagatc 5880agcctggtca acatggtgaa accctatctc tactaaaaac acaaaaatta gccaggtttg 5940gtggcgggtg cctgtaattc cagctactca ggaggctgag gcaggagaat cgcttgaacc 6000tgggaggtgg agtttgcagt gagccgagat catgccactg cactccagcc tgggagacag 6060aacaagaatc cgtcctcccc cctacaaaat aaataaataa ataaaaaggc tgggcaatgt 6120ggctcacgtg tgtaatcaca gcactttggg aggccaaggc aggcgaatca cctgaggcca 6180ggagtttgag accagcctgg ccaacatggt gaaactccgt ctctactaaa aatacaaaaa 6240ttagctgggc gctgtggtgc gcgcctgtaa tcccagccac ttgggaagct gaggcatgag 6300aatcgcttga acccaggagg cagaggctac agtgagccaa gatcgtgcga ctgcactcca 6360gcctgggtga cagtgcgaga ctccgtctca aaaaaacaaa caaacaaacc aaaaaacttg 6420attggctgat gttgagggga cgatagagag gctatggtgt gtgattttat ttctataaag 6480ggcaaaacta gacatcaatc tctctgtggg agagatgggg ctcctccaag gttcccggga 6540ctaggaatgt gctcattctt ggtctgggca tcggtgacat caaagtgtcc ctttggtaag 6600gttctttccc ccacaagact tcccttccca cagtaaccac cacaccgctg tgccaattgc 6660ccttcctgtt tggtttaaca ggcgtttgtt gatcgcttac cggcacatca tcaagaaata 6720tacaaattaa tgcacattaa ttgagttgac actttaggcc tggattgcgc tcagcagacc 6780acctcaatga ggatgctggg gagtcagccc atttcacagc tgcgaaagct gagtcctagg 6840ggtcctagtc ctctgattgt cttaaacctc attaggccag gcgcagtttc tcacgccggt 6900aatcccagca ctttgggagt ccgaggcagg aggatcactc gaggtcagga gttccagacc 6960agcctcgcca acatggtgaa accccgtctc taccaaaaat acaaaaatta gccgggcatg 7020gtggcgtgcc cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgaacc 7080caggatgcag agtaagccga gattgtgcca ctgcactcca gcctggatga cagagctaga 7140ctctgtctca aaacaaaaac aaaaaaaccc tcattaatgc cgccccaccc cagccacagg 7200gcattatttt ggatcatagt ttttgtattg tgtttttttt ctagagataa ggtcttgctc 7260tgtcgcccag gctggagtgc agtggtgtga tcatagctca atgcagcctc aacttgcaga 7320gctgaaggca tcctcctgtc tcagcctccc aagtagctag gactatgggg gtgtgccacc 7380atgccctgct aattttttag agatgaggtc tcaaaatcct agcctcaagt gatccacctg 7440cctcggcctg tcaaagtgct gggattacaa ggcttttttt tctttttgag aggaggtctc 7500actatattgc ccagtctggt ttcaaactcc tggtctcggc caggcgcggt ggctcacaca 7560tgtaatccag cattttggga ggctgaggca ggctgatcac ttgaggccag gagtttgaga 7620tcagtgaaac cccatctcta ctaaaaatac aagaaaatta gctgggcgtg gtggtgccca 7680cctgtaatcc cagctactgg ggtggctgag gcacgagaat ctcttgaact tgggaggcgg 7740aggttgcagt gagctgagat tgcgccactg cactccagcc tgggtgacag cgcgagactc 7800tgtctcaaaa aagcaaaaaa cataaaacaa actcctggtc tcaagctatc cttccttctt 7860ggcctccgga aatgatggga ttacagacat gagccactgc gccctgctgg aacttaggtt 7920tttgtttgtt tttcccaaca ctttcttcag atcttcttca ttcaggtcaa tttgagtgac 7980ctcctttttc tccccaattt ttctcagggg actcgaagcc ccacccctgg ccccacccag 8040ctgagggccc tgagtgctga ggtttctcag ggcaagtgag cgagcgggtg ggaggtgttg 8100ggggctggaa gcagggggcc agtttcctcc tgggcccatc ccagggaggc tttccttctt 8160tctttctttc tttctttctt tttttttttt tttttgagac agagtctgac tctgttgtcc 8220aggctggagt gcagtggtac aatcttggct cactgcaacc tctgcctccc aggttcaagt 8280gattgtcctg cctcagcctc ccgagttgct gggattacag gaacgcacca ccacacccgg 8340ctaagttttg cactttttag aggcagggtt tcgccatgtt ggccaggcag gtctcaaact 8400cctgacctca agtgatcctc ccgcctcggc ctcccaaaat gctgtgatta caggcataag 8460ccaccgcacc cggcctccag cactcctttc catgccctcc ctgctcagaa gtccaatccc 8520ctctgaccag gactgagggg ctttttctct ctgtgcccca ggcaagttgc actcatggca 8580cctccaagtg aagagacgcc cctgatccct cagcgttcat gcagcctctt gtccacggag 8640gctggtgccc tgcatgtgct gctgcccgct cggggccccg ggccccccca gcgcctatct 8700ttctcctttg gggaccactt ggctgaggac ctgtgcgtgc aggctgccaa ggccagcggt 8760gagtgcatcc ctagtggatc gggccagagg gaaggatggg gctgtgtggg gccaagattg 8820gaagctggaa tagttgcctg cagaagtcag catcggagct ggggctttgg gggatgagta 8880ggagttttgt aatggagaag ggtgtgcagg gttggcttct gaggcagagg gaatggcctg 8940tgcagacgga gaggtgtgac ggcacatgaa gggaacagct ggtcatacct tgaggtatgg 9000aaggatctgg acggttgggt atgatgctgg cactcctgaa gggcacagat ggggtgactc 9060aggagggagc tgatgggacc atcccctgta ggcatcctgc ctgtgtacca ctccctcttt 9120gctctggcca cggaggacct gtcctgctgg ttccccccga gccacatctt ctccgtggag 9180gatgccagca cccaagtcct gctgtacagg attcggtagg aagtgccccc cagcccccag 9240ggattgtaca attttatcat ctccttgcat ttcgaggtgc ccacacccct gccccaggga 9300ggtatggtca ctacccattt ctcagatgag gaaacagacc agagagggtg ggtcacttgc 9360ccaaggtcac acagcaagtt aaaggtacaa gctgggctct gtgaggcctc cgcagaatct 9420gtccctcgcc cccaccataa tgtcactcct actgaggctg ggttgcactt tcatcccagg 9480gttctctcct ctcctcacag cttttacttc cccaattggt ttgggctgga gaagtgccac 9540cgcttcgggc tacgcaagga tttggccagt gctatccttg acctgccagt cctggagcac 9600ctctttgccc aggtggggtt ctgcctgggg tttgacccag ggggttgggg gtccaagggg 9660caacatgagg actggcatgc aatcaggtgg ggcctcgtct gaccctccct gtggcagtcc 9720aggggtgggg gtcagcccag gattgggggg gtctgcaggt taacaacagg gcttgaagtt 9780gggtggcctc agctgatgct ccctgtggcg gccccccagc accgcagtga cctggtgagt 9840gggcgcctcc ccgtgggcct cagtctcaag gagcagggtg agtgtctcag cctggccgtg 9900ttggacctgg cccggatggc gcgagagcag gcccagcggc cgggagagct gctgaagact 9960gtcaggtgag agccaccagg ctgtggggac ggcctctgct tgggagtgag caacgtgggc 10020tccatcgggg ctttgccggg ctcccaccat ggagttctcc tgcaagcttt cagggtgttc 10080ctatgaccca gggcctccca cgaacccagc cctctccacc cccaggctcc agctggacag 10140acacctgacc tcccccagct aaaaggcctg tggggtccct gtccgacctg tgggcgccaa 10200tggccctccc ctactctgag gtccggtcct catacctgac cctgaatgag agtctgtgtg 10260tgcctggtgc cccaactagg gccgcacccc agcccctggg ctaaagcctg ggtttgtgtg 10320tgtccccgcg gggacccctc ccgacgctga gggccggctc cctcccctcc aacccctgca 10380gctacaaggc ctgcctaccc ccaagcctgc gcgacctgat ccagggcctg agcttcgtga 10440cgcggaggcg tattcggagg acggtgcgca gagccctgcg ccgcgtggcc gcctgccagg 10500cagaccggca ctcgctcatg gccaagtaca tcatggacct ggagcggctg gatccagccg 10560gggccgccga gaccttccac gtgggcctcc ctggggccct tggtggccac gacgggctgg 10620ggctgctccg cgtggctggt gacggcggca tcgcctggac ccagggagaa caggaggtga 10680gggcggactc ccccgctggg cggggccaac gtgggggcgg ggctcgggga ggggccggag 10740agtggtaggg gatgtggggc ggagccaaaa cgaaagactt ggggaagtgg gcgaggctta 10800atgaggggcg gggcttagtg agggaggaga ctgcgggaat gggaggggca aactgagtga 10860agggttgggc tgagcgaccc gggaatgaaa atgggagggg ttgaggagtg ggtgggtggg 10920cgctggaacg aggcaagact aagaggcaga gtgaggctcc gagagctggg aggctgcgaa 10980gcggggcagg gatcaagggg cggggtccgg cagagagaag gaggcgggga ttggcagagc 11040gggtgggaga tgtttgggga tgggtagggg aggtgttgag aggttggagt tgataggagg 11100gggcgcggct tggaagggtt gaatggcaaa gggataggga gtggatggtg tggcttgggg 11160gtgggttcat gggcgtggtt tggcggggtc cagctgggcc cccacttcgg tactccccct 11220ccttcccagg tcctccagcc cttctgcgac tttccagaaa tcgtagacat tagcatcaag 11280caggccccgc gcgttggccc ggccggagag caccgcctgg tcactgttac caggacagac 11340aaccagattt tagtgggtgc aggattcccc tccccttcag ccttaccccg agggcgggac 11400cggcaccctc gggtttcact gggctctgac gcttgtccct cgcaggaggc cgagttccca 11460gggctgcccg aggctctgtc gttcgtggcg ctcgtggacg gctacttccg gctgaccacg 11520gactcccagc acttcttctg caaggaggtg gcaccgccga ggctgctgga ggaagtggcc 11580gagcagtgcc acggccccat cacgtaagga cctgtccccc attcccggcc tctgtggcca 11640ctcagggccc ctccccttct ctatgcctca gtgtcctcac cttccaggag ccctggacag 11700gggtcaagtt ttcaaaccac acctgccgca cagtcagcgc tcagtgaagc tgaagtattc 11760cttctgcttc acagggcgac cactactctc tctctctctg accccagggc catttcctgg 11820agatggacaa gtcgcccacc ttcacctaca gcctcttgtt taatctccca ggaagggcca 11880ggcatagtgg ggcacacctg caatcgcagc gctttgaggg gccaaggcag gaggattgtt 11940tgaactcagg agttggagac aagtctaggc aacaggagag accccatctc tacaaaaaaa 12000gaaaaaaaaa tagctgggtg tggtggttga cctgtagtcc cagcgactcc ggaggctgag 12060gcaggaggat cacttgagcc caggagttgg aggctgcagt gagctgagat tgcactccag 12120cctgggcaac caagcaagac cctgtctcta ttaaaacaaa caaacaaaca aacaatctcc 12180cagaagaggc caagacttac ggctgatttt cttttttctt tttttttttg agacggagtc 12240tggctctgtc gcccaggctg gagtgcagtg gcacgatctc ggctcaatgc aacctctgct 12300tcccagggtc acgccattct cctgcctcag cctcccgagt agctgggact acaggtgctc 12360gccaccacgc ccggctattt ttttgtattt tcagtagcga cggggtttca cggtgttagc 12420caggatggtg ttgatctcct gacctcgtga tccacctgcc tcggcctccc aaaatgctgg 12480gattacaggc gtgagccacg gcgcctggcc catggctgat tttataaatg gggggagggt 12540gtcacctggc aaggatccca gggctacaga ggtacctgaa tttgagccca ggtctctctg 12600tcttcttcta tctctgactc ctccccattc cctctcacct tcccccacag tctggacttt 12660gccatcaaca agctcaagac tgggggctca cgtcctggct cctatgttct ccgccgcagc 12720ccccaggact ttgacagctt cctcctcact gtctgtgtcc aggtcggtct actgctaggg 12780tgggtagtgg agggctgcct ggaggaggtg acgtttgaat tgagatttaa aagatcagtc 12840agcatttggt tcctgaagaa taggagggaa aagacacccc cggtgaacag aacagcatat 12900tcaaaggtct aaagactgga atgagttcat ggtgctttag gagaaaggac tgaggctggg 12960cacagtggct tacgcctgta atcccagcac tttgggaggc tgaggtaggc agatcaagag 13020atcaagagat cgaaaccatc ctggccaaaa tggtgaaacc ctgtctctac taaaaatata 13080aaacttagct gggcgtggta gtgggcatct gtagtcccag ctactcggga ggctgaggca 13140ggagaatcgc ttgaacctgg gaggcggagg ttgcagtgag ccaaggtcac gccattgcac 13200tccagcctgg gtgacagagc cagactccgt ctccaaaaaa aaaaaaaaaa aaagaaaaaa 13260aaggaagaag gactgagaag gagagtgtct gtcgctcagt cccactcagg ggccactctt 13320ctttgcagaa cccccttggt cctgattata agggctgcct catccggcgc agccccacag 13380gaaccttcct tctggttggc ctcagccgac cccacagcag tcttcgagag ctcctggcaa 13440cctgctggga tggggggctg cacgtagatg gggtggcagt gaccctcact tcctgctgta 13500tccccagacc caaaggtgag ccccttcctc ccctggaatg agtggctgat ctgggaccct 13560ggctttctat gtctgtgaca gctcctgtgt gggtggcaag tggcagaaac tgcaggtcaa 13620ggtgggttag ggaagaaaag gtgatttgtt ggctcaggaa gttagagata tataaccttt 13680aggtctggct tgatctaggc acagctagat gtgagccatg tcatctgcac ctagtctctc 13740tccagctctc agctcttcct ctgggtgaat ttcactcctg gacaaacccc tctgatggga 13800caattctgag atgtgagttc ttctgagtct cccagaatcc ctggtagaac cgatccctgg 13860ttgtccacag tgccacttgc tcattaaagc cccctgcagg gctccttcct tccttgtcgc 13920tcatcccaaa tccctatggg ggctttctgg atctcctttc aaataaacca tgtgccagcc 13980aggcacagtg gctcacgtct gtaataccag cacttcggga ggctgaggca gatggatcac 14040ctgaggtcag gagtttgaga ccagcgtggc caacatggtg aaactccatc tctactaaaa 14100atacaaaaat tagctgggtg tgctggcaca ctcctgtagt cccagctact tgggaggctg 14160aggcaggaga attacttgaa cccaggaggc agaggttgca gtgagccgag atcacaccac 14220tgcactccag cctgggtgac agagcgagac tctgtctcaa aaaaaaaaaa aaaaaaaaat 14280tagccgggca cggtggcaca cacctgtagt cccagctatt cgggaggccg aggcaggaaa 14340atcgcttgaa cctgggaggt ggaggttgca gtgagctgag atcgcaccac tgcccaccca 14400gcctggatga cagagtgaga ctccgtctca acagcagcag caacaacaaa acaaaaacaa 14460caacaaaaag ccatgtgccc tgaagtcttc atctcagggt cggcttctag agggtacctc 14520aaactaaggc atgagttagc taacccttgg ggacttttca cctctgattt ctggtttttc 14580tccctcatcc tctccccata gaaaagtcca acctgatcgt ggtccagaga ggtcacagcc 14640cacccacatc atccttggtt cagccccaat cccaatacca gctgagtcag atgacatttc 14700acaagatccc tgctgacagc ctggagtggg taagaggccc tgggaaatga ggcgatacct 14760cagtctgggg tccagagact cagatgcgtg gcctcaggca tatgctataa ttttaccttg 14820cctcggtttt cccatctgta aaatggggcc agcagctatg tctcgcttgg gctgggatcc 14880tgcaggaacc ccctcactgg cctcttctgc tgtcccctca ccattcagca tgagaacctg 14940ggccatgggt ccttcaccaa gatttaccgg ggctgtcgcc atgaggtggt ggatggggag 15000gcccgaaaga cagaggtgct gctgaaggtc atggatgcca

agcacaagaa ctgcatggag 15060gtgagagcaa tgtggaccag acttttggag tcggggctgg ctggagaggg ggtcgtggat 15120gcagagaaat ttaaaaacac acagggacct gggcgtggtg gctcatgcct gtcatcccag 15180cactttggga ggctgaggca ggaggatggt ttgaagccag gagttcaaga acagcctagg 15240caacatagcg agacctcgtc ttgacaaaaa aattttaggc cgggcgcggt ggctcacgcc 15300tgtaatccca gcactttggg aggctgaggc gggcagatca tctgaggtcg ggagttcgag 15360accagcctga ccaacatgga gaaaccccgt ctctactaaa aatacaaaat tagccgggcg 15420tggtggtgca tgcctgtaat cccagctact cgggaggctg aggcaggaga attgcttgaa 15480tctgggaagc ggaggttgca gtgagtcaag atcgcgccac tgcactccag cctgggtgac 15540agagggagac tctgtctcaa aaacaaaaca aaacaaaaca aaaaaccata gatgatagtg 15600ggaacttctg tcccgtatca gaaaatcatg gtagtgctgt gtgcactaat ggcagactcc 15660agggccaaag gtgacctgtg gccaggtgtt cccctaaggc aggtctgtga gcacaaaatt 15720tgggattatt ggagtggaag aaacccacgc atcttctctc ccttcccacc ttccccagtc 15780attcctggaa gcagcgagct tgatgagcca agtgtcgtac cggcatctcg tgctgctcca 15840cggcgtgtgc atggctggag acagtgagag ccccccaccc acccacccca cccctgcctc 15900acccaagtct aggctgttct tcccacctct gttctgagcc gctatatgac agccccagca 15960acacactggg ccaccctgga tgggagccgt gttcattacc ctttatttat gtctctccat 16020catcactcct tggaaagcgg ctccaggttc tcacccatat ccagccccag aatgacctga 16080agtcagacaa acctggcttt ctaatctctg cagctttgta caggtcacgt aacctttctg 16140agccttggtt tcattggttg ggagtctagg atgggccagg agctgggaca gagcctagaa 16200tgtgacaggc agggtgtgat gaggtgtgag gagggcagca cggagcactg tggatggtca 16260gagaggctgc tgggccagcc tgggggttgg gcaatgcttg tgggaagaca gagatgcatt 16320ctaacctgga aagataagga caagtgtgga ttaggaaagg aagaggggtg ttctaggcag 16380aggacacaga atatgcaaag ggttagaagt gagatacaga ggctgggcgt ggtggctcat 16440gcctgtaatt gaaaagccga ggcgagtgga tcacctgaga tcaggagttc aagaccagtc 16500tggccaacat ggcaagaccc cgtctctact aaaaatacaa aatcagccgg gtgtggtggc 16560atgcgcctgt agttccagct acttaggagg ctgagacagg agaatcactt gaacccggga 16620ggcagaggtt gcagtaagcc gagatcgcac cactgcactc cagcctgggc aacagagtaa 16680gactctgtct caaaagaaaa gagaaaaaaa aaagtgagat acagatacag acagggctca 16740acaccttcca ggcattccag gcaaatcatt cagagatgga ggtgggagga gaggtgagta 16800ctgtatgaac agaggcagca ggggagggaa cagacagaga tgagagtttg agagaccctg 16860agagccaggg tgttggcaga acctcctcaa cacaagtgca gttcagtctc ccaaccccgc 16920ctctccctgc tgccaaccag gcaccatggt gcaggaattt gtacacctgg gggccataga 16980catgtatctg cgaaaacgtg gccacctggt gccagccagc tggaagctgc aggtggtcaa 17040acagctggcc tacgccctca actatctggt gagtgctcct ctgcctgctc caccctccat 17100tcccagggaa ggctttctct gggtggaaga ggaattggga gtgggctctg tagtatgcat 17160aggagtttgg taagggttcg aggggagggc attttaggtt caggttgtga gaacactaga 17220agagaacaag tcattcttgg atgtcagggc gtgtggtgaa tgacgaggct gggcaggaag 17280aaaggcttcc tagaagaagg aacattggag atagggcctt aaaagttgag tagaagttca 17340tcaagagaag aaaggaagga aggaatgtca ggctgaggga acagcctagg caaaggcctg 17400caggctagat agtgtgttgc atcccctggg gcctatcagg cagttctgtt ggcaggagac 17460cagggtgcaa gtgtggaagg gaagttcatt ggaagcttga gcaagggcct tgaatgccag 17520gctgaggagc tttcactttg tgtcaaaggc actggggagt cacaggatgg ggtggtgttt 17580gagaagggga gggacatagc caggtcagtg tagggggtga actagagggg caagacagga 17640tgtcaggagt cagggacgat gctggagcat gtctgagcag taccaagtgg gttttgaagg 17700atgtatagga gtttgccaaa cagactcttc attcatcaaa ccctcccggg cattttcctg 17760tgtctggccc ccttaggagg acaaaggcct gccccatggc aatgtctctg cccggaaggt 17820gctcctggct cgggaggggg ctgatgggag cccgcccttc atcaagctga gtgaccctgg 17880ggtcagcccc gctgtgttaa gcctggagag taagttcctg gaggtggagg agggaggggc 17940tgagcagggc aaggaagtgg atccctgatc ccactttcat tccctcagtg ctcaccgaca 18000ggatcccctg ggtggccccc gagtgtctcc gggaggcgca gacacttagc ttggaagctg 18060acaagtgggg cttcggcgcc acggtctggg aagtgtttag tggcgtcacc atgcccatca 18120gtgccctgga tcctgctaag gtcagagccc ctcacccggc atcggtctcc gaacccccac 18180tttgacagaa gggcagactg acatccagtc tggggagatt ggggtgggtc tattgggttg 18240gggattaccg actgctcctc tcaccctcag aaactccaat tttatgagga ccggcagcag 18300ctgccggccc ccaagtggac agagctggcc ctgctgattc aacagtgcat ggcctatgag 18360ccggtccaga ggccctcctt ccgagccgtc attcgtgacc tcaatagcct catctcttca 18420ggtgcccgct gggacgggtt gggtggggag ggctgtgatg tcatattggg cccagtggaa 18480ggagcgtggt ttgcagcagg ccacgccctg tgtgtctggt gaggttggag gggttggtga 18540ctgtgacagt cagtgtgagc ttcaacagct actgtaacga acagtcccct cagttcaagg 18600ttcaacatga tgatatttta tttatttatt tatttttgag acagagtctt gctctgttgc 18660ctaggctgga gtgcagtggc acaatttcgg ctcactgcaa cctctacctc cttgaacctc 18720tagttcaagc gattctcctg cctcagcctc ctgagtagct gggattacag tgtgtgccac 18780cacgcccagc taatttttgt atttttggca gatatggggt ttcaccatat tggctaggct 18840ggtctcgaac tcttgacctc aggtgatccg cccacctcta cctcctaaag tgctgggatt 18900tcaggtgtga gccaccatgt ctggtctatt tcattctttt aaaaaaatgt ttggctgggc 18960gcagtggctc atgcctatag ttccagctat aggtaggtgg atcgcttgag cccaggagtt 19020caagaccagc ctgggcaaca tggcaaaact ccatctctac aaacaaacaa acagaaaatt 19080agccaggcat ggtgatgcat gcctgtatgc atttttattt tattttattt tatatttttg 19140agacactatc tccctctgtc acctaggctg gagtgcagtg gcgtgatcct ggctcactgc 19200aacctctgcc tccctggttc aagcaattct cccgcctcag actcccaagt agctaggatt 19260acaagggcgt gccaccaaac acggctaaat ttttgtattt tttagtaaag acagggtttt 19320gccatgttgg ccgggctagt cttgaactcc tggtctcaaa gagatccgtc cacctcagcc 19380acccagtgct gggattacag gcatgagcca ccacaccagg ctggattttt tttttttttt 19440tttttttttc tgtgatgggg ttttgctatg ttccccaggc tggtcttgaa ttactggctc 19500aagcaatcct cctgccttag tctcccaaat agctgggatt acaggcacac acaaccatgc 19560ccagtgtgat atttagtctt cattcaatga gggtgtccag gcccacagga acctctcact 19620tagtggctgc actcacctca ggcgttgggt ccccgttgga tcctctgcag ataaaagaga 19680gagtgtggag ggccccgtat taggtttcca tgggtcagga ctggaggggc acccagcata 19740tcttgtccat cagcctgagc tcagtcatgt ggccacattt catagcagtg gaactgggga 19800aatgagttct cattatgtcc tccatctttg tagccatgtg gagttgcaca gggtgtgcac 19860tgcacgagga ggcttccttt gcctgggaca gagtgggaga cacctttttc cagtctccac 19920aaggtaccct ttggcttgca atggccctgc cataatgcac agagagggtc aatatgcaga 19980tggaggttgc acagcaagtc aactcaggag tggggcccag gatgagaggc gctgcttacc 20040actgcccatg cccccacccc agactatgag ctcctctcag accccacacc tggtgccctg 20100gcacctcgtg atgggctgtg gaatggtgcc cagctctatg cctgccaaga ccccacgatc 20160ttcgaggaga gacacctcaa gtacatctca cagctgggca aggtaaggtg ggcagggcca 20220gggtgggttg gagagggcag ggcagcatcc aggtgcctgg acatcagtcc cgctatcccc 20280cagggcaact ttggcagcgt ggagctgtgc cgctatgacc cgctaggcga caatacaggt 20340gccctggtgg ccgtgaaaca gctgcagcac agcgggccag accagcagag ggactttcag 20400cgggagattc agatcctcaa agcactgcac agtgatttca ttgtcaagta tcgtggtgtc 20460agctatggcc cgggtgagcc agctcccgga tgagtgaacc aagacgtatg ggtgcttttc 20520aaagtgcaca ttcttaccct cctgccaggc cactttaggt aggctgggaa cgtgattatt 20580gatccagatt cacatgggtt acaggtttga atcctgactc taccccttac cagttgtgaa 20640accttaactt ttctgagcct cagtttctcc agctgaaaaa tgggccattg tgatatttac 20700tttgttgttg ttgttgtttg tttgtttttt tgagacagag tctcgctctg tcacccaggc 20760tggaggcagt ggctcaatct cggctcactg caacctctgc cttccaagtt caagtgattc 20820tcctgcctca gcctccagag tagctgggat tacaggagcg tgccaccaca cccggctaat 20880ttttgtgttt ttagtggaga tgggttttca ccatgttggc caggctggtc ttgaactcct 20940gacctcaagt gaggcttcca aagtgctggg attacaggcg tgagccactg cacctggccg 21000tgatatataa acacatcaat gtatgttgta gaaagtactc aagagatatt agcaatgtgt 21060cattgttgcg gttcccatat tacagtcagc aaaactgagg tcgagaggga cacaaggtcc 21120cactgtgaaa ggggggaaga atggggggac gagcagggct gggccctgct gtgacagatc 21180ctgccttctc caggccgcca gagcctgcgg ctggtcatgg agtacctgcc cagcggctgc 21240ttgcgcgact tcctgcagcg gcaccgcgcg cgcctcgatg ccagccgcct ccttctctat 21300tcctcgcaga tctgcaaggt gcgagggggc gccccgggac ttgtggggat tcagctggca 21360cggcctgggc aggggtctgc ttggaggtcg cggtgaaggc tgaggagtgg tttggggtcc 21420aggtctcggg agtggtgggg ttggcttagg gctcaggatc agaacttcag tggaggatgg 21480ctcgggggta gggttatagt tggggtctgg gttggggtgc caggtcacgc ttggggtacc 21540tgccggatta tcctgggatc ctctctgcac gctcacaccg cccgcccgca gggcatggag 21600tacctgggct cccgccgctg cgtgcaccgc gacctggccg cccgaaacat cctcgtggag 21660agcgaggcac acgtcaagat cgctgacttc ggcctagcta agctgctgcc gcttgacaaa 21720gactactacg tggtccgcga gccaggccag agccccattt tctggtgggg aacccgcgcc 21780taggctccgc ccctattccc cacggctctg gctccgcccc cagccatgcc cccgccccct 21840cccgctgctt tgctccccag ccttagcccc gcccttcctc cgctgcagct ttggcccctc 21900ccactcccca gagccccgcc ccctcaacag cactggctcc tctgtctccc gctgccctgc 21960tgtcagcggc ccccagcctt agccccgccc ttctctcagc tctcgccccg cccaagcttc 22020agaaccccac ccctccaaca cgctggctcc gcccctcagg gctggccccc tcttagttcc 22080gcccttcccc ccgcccagtt ctggcccctc cccctcccac ggctctggcc ccgcccccat 22140ctccgcccct ccgtgctgcc cccgcctcct ccccacagcc ttagctcttc ccaggcacct 22200cccagggctg gagaatccac ctatcccaca gccagggaaa ccgagaccct ggagacggga 22260ctgacctgct cacagtcccc acctaccctg accagttccc cattccaagg ctgcccccct 22320cttcctgtcc tttctacacc ctcgcatctc aagaccttgt cccctctcca ggtatgcccc 22380cgaatccctc tcggacaaca tcttctctcg ccagtcagac gtctggagct tcggggtcgt 22440cctgtacgag ctcttcacct actgcgacaa aagctgcagc ccctcggccg tgagtcggct 22500tcccagagcc cccagccttc ttctccctcc acgcccctcg tggccaatct ccaacctgtc 22560tgcgcctgcg tccctcttta gcatggggtc acctggtccc agcatcatag gccccagtgg 22620ggaggacgct tcctcacctt tctgacccct tcacggttca ggcagcccct ccccgctcca 22680tcacagatgg cccctacccc caccacgggt ggcccctccc cctccaccca cggaggctcc 22740tcccccacca catgcgctcc tccttggctc caggagttcc tgcggatgat gggatgtgag 22800cgggatgtcc ccgccctctg ccgcctcttg gaactgctgg aggagggcca gaggctgccg 22860gcgcctcctg cctgccctgc tgaggtgagc gccgcagggc tagcctcagt ttcccagtct 22920gtagattggg ccggggtctc gggcaagcca gctggcgcct gagtctctgt actgagaaga 22980aaggctagag tgtgaggccg atgaggatcc tggcccccac ttggctactc tctcactgtg 23040tggcaagtca gagcactttc agagcctcag tttacccttt tccaaaatga gaatagtaat 23100gccttatagg gtgagggaag attagactcc tgaacacctg tgcctatgag ggctcagctc 23160aaagccgagc acacagtcga tgctccataa atggtggtga cgttcatggt tttttttttt 23220ctttctttct ttctttttta tagatggggg ctcactctgt tgcccaggct ggggtgcaat 23280tatagctcac tgcagcctcc aactcctgag ctcaagtgat tcccctagtt cagtgtctct 23340agtagcagga gctacaggtg tacaccacca cacttggcta atttaaaaat aattttttag 23400agatgggagc ctcactatat tgcccaggct ggtcttgaac tcgtgggctc aagcgattct 23460cctgcctcag cctcccaaag tgctgggact ataggtgtac atcaccatgc ctggctaatt 23520taaaaataat tttggccagg tgtggtggct cacacctgta aacccagcac ttttgaaggc 23580tgaggcggtc agatcaccgg aggtcaggag ttcgagacta gcctggccaa catggtgaca 23640ccctgtctct actaaaaata caaaaattac ccatgtgtgg gtgcctgtga tctcagctac 23700ttgcgaggct gaggcaggag aattgcttga acctgggagg ggaaggtttc agtgagccaa 23760gatcatgcca ctgcactcca gcctgggcga cagagcaaga ttccatctca aaataaataa 23820ataaataaat aaacaaacaa ataagataaa aataattttt ttaagagaca aggtctcgct 23880atgttgccca ggctggtctt gaactcctgg gctcaagcga tcctcctgcc ttggcctccc 23940aaagtgctga gatttacagg cataagccac tgtgcctggc taattttaaa aaattttttt 24000aaagagatgg ggtctctctg tgttgcctag gctggtcttg agctcgtggg gtcaagtgat 24060cctcctgcct cggcctccca aagtgctggg attacagacg tgagccacca catcccaccc 24120tctcatggtt tataatcata taatcataac ctttgtggaa gtgtctgaca tgcagttggt 24180cattgataaa ttaatttgct caggccaaaa acatttattg agtgccaact gtgtgccagg 24240acttgttggg tgctgaagac cctgtcctcc cagtaactag caaaatctga taagaacatt 24300ctaggctggg cacgatggct catgcctata atcccaacac tttgggaggc tgaggcagaa 24360ggatcactgg agcccaggag ttcaagacca gcctgggcaa cgtagtgaga ccttgtctct 24420acaaacaata caagcaatag ccggtgtggt gacatgcacc tgtggtttca gctactaggg 24480aggctgaggc aggaggatca ctggaaccca ggagttcaag accagcctgg gcaacatagt 24540gagaccttgt ctctacaaac aatacaagca atagccggtg tggtgacatg cacctgtggt 24600ttcagctacc agggaggctg aggcaggagg attgcttgag cccaggaggt taaggctgca 24660gtgagccatt attgtaccac tgcactccag cctggacaac agagtgacac cctgtctcaa 24720aacaaaacaa aacaaaacaa aacaaaacaa aacaaaacaa aacaaagaca aaattatggt 24780agtgataagt gccttgaaag agatgaacag agggaaatgg tggggtgggg gtggtcaaag 24840agggcctctt acggggccga cgctggaagg aggaggagcc tacccatgag taaagctagg 24900agaagaaatt tccagtggag gacacggaag ggaaaaaggc cttggggagg taatgagctg 24960ggtgccttta agcaccagtg cgatggaggc agatgtgact gcccggaaca aatgagggaa 25020ggagggatgg agatgagcga aggagggcat cagggagagg tggtgttttt ttgttgtttt 25080tttttttttg agacgtggtt ttgctcttgt tggccaggct ggagtgcaat ggcgcaatct 25140cggctcacca caacttccgc ctcccaggtt caagcaattc tcctgcctta gactcccgag 25200tagctgggat tacaggcaca cgccacctgt aatttttttt tttttttttt tttttttttt 25260tttttttttt ttttagttaa gatggggttt ctccatgttg gtcagggtag tctcgaaagg 25320agaagtgtgt tgtaaaatcc ataagggctg ggcgcggtgg ctcacacctg taatcccagc 25380cctttaggag gccgaggtgg gtggattaca tgaggtcagg agttcaagac cagcctgacc 25440aacatggtga aaccccgtct ctactaaaaa tacagactta gccaggtgtg gcggtgtgtg 25500catgtaatcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc caggaggcag 25560ggtttgcagt gagccgagat cgcaccactg cattccagcc tgggcaacaa gagcgaaact 25620ttatctcaaa taaataaata agtaagatcc atagggagcc atgggagttt ttggagcaga 25680gatgggatgg aatttaattt gtgttttaaa actgaatgag tgcggtggct catgcctata 25740atcccagcac tttgggaggc caagacaggt ggatcacctg agatcaggaa tttgagacca 25800acctggccaa catggtgaaa ccctgtctct actcaaaata caaaattagc caggcgtggt 25860ggcacgtgcc tataatccca gctactcagg aggctgaggc aggataattg cttgaacccg 25920ggaggcggag gttgcagtga gccgagatca tgccattgca ctccagcctg gacaacagag 25980ctagactccg tctcaaaaaa acaaaaacaa atacgctgaa tgggagttgt gtcctttgga 26040ctgctcaggc acgaccccat tatctgtccc ccgcccctca ggttcacgag ctcatgaagc 26100tgtgctgggc ccctagccca caggaccggc catcattcag cgccctgggc ccccagctgg 26160acatgctgtg gagcggaagc cgggggtgtg agactcatgc cttcactgct cacccagagg 26220gcaaacacca ctccctgtcc ttttcatagc tcctgcccgc agacctctgg attaggtctc 26280tgttgactgg ctgtgtgacc ttaggcccgg agctgcccct ctctgggcct cagaggcctt 26340atgagggtcc tctacttcag gaacaccccc atgacattgc atttgggggg gctcccgtgg 26400cctgtagaat agcctgtggc ctttgcaatt tgttaaggtt caagacagat gggcatatgt 26460gtcagtgggg ctctctgagt cctggcccaa agaagcaagg aaccaaattt aagactctcg 26520catcttccca accccttaag ccctggcccc ctgagtttcc ttttctgtct ctctcttttt 26580atttttttta tttttatttt tatttttgag acagagcctc gctctgttac ccagggtgga 26640gtgcagtggt gcgatctcgg ctcagtgcaa cctctgcttc ccaggttcaa gcgattctcc 26700tgcctcagcc tcccgagtag ctgggattac aggtgtgcac caccacaccc ggctaatttt 26760ttttattttt aatagagatg aggtttcacc atgatggcca ggctgatctc gaactcctaa 26820cctcaagtga tcctcccacc tcagcctccc aaagtgttgg aataataggc atgagccact 26880gcacccaggc tttttttttt ttaaatttat tattattatt tttaagagac aggatcttgc 26940tacgttgccc aggctggtct tgaactcctg ggctacagtg atcctcctgc cttatcctcc 27000taaatagctg ggactacagc acctagtttt gagtttcctg tcttatttcc aatggggaca 27060ttcatgtagc tttttttttt tttttttttt tgagacggag tctcgctctg tcgcccaggc 27120tggagtacag tggcgcaatc taggctcact gcaagctccg cctcctgggt tcacaccatt 27180ctctcgcctc agcctcccaa gtagctggga ctacaggcgc ccgccaccac acccggctaa 27240ttttttgtat ttttagtaga gacggggttt caccttgtta gccaggatgg tttccatctc 27300ctgacctcgt gatctgcccg tctcggcctc ccaaagtgct gggattacag gcatgagcca 27360ctgcgcccgg ccctcatgta gctttaaatg tatgatctga cttctgctcc ccgatctctg 27420tttctctgga ggaagccaag gacaagagca gttgctgtgg ctgggactct gccttttagg 27480ggagcccgtg tatctctttg ggatcctgaa agggggcagg aaaggctggg gtcccagtcc 27540accctaatgg tatctgagtg tcctagggct tcagttttcc cacctgtcca atgggaccct 27600ttctgtcctc accctacaag gggcacaaag ggatgacacc aaacctggca ggaacttttc 27660acgcaatcaa gggaaggaaa ggcattcctg gcagagggaa cagcatgcca agcgtgagaa 27720ggctcagagt aaggaggtta agagcccaag tattggagcc tacagttttg ccccttccat 27780gcagtgtgac agtgggcaag ttcctttccc tctctgggtc tcagttctgt cccctgcaaa 27840atggtcagag cttacccctt ggctgtgcag ggtcaacttt ctgactggtg agagggattc 27900tcatgcaggt taagcttctg ctgctcctcc tcacctgcaa agcttttctg ccacttttgc 27960ctccttggaa aactcttatc catctctcaa aactccagct accacatcct tgcagccttc 28020cctcatatac ccccactact actgtagccc tgtccttccc tccagcccca ctctggccct 28080ggggctgggg aagtgtctgt gtccagctgt ctcccctgac ctcagggttc cttgggggct 28140gggctgaggc ctcagtacag agggggctct ggaaatgttt gttgactgaa taaaggaatt 28200cagtggaaaa gattttgtgc tggacttggg gcgatgggga gcctcagagg gtgtgtgagc 28260tgggagggat gcggttagag ctgtgggcca gagacctctc agggagccac tgtgggggcc 28320ccagggcagg ctggtggagg aggaccactg ggtggggctt ggctggggcc ctcaaggaca 28380gagccccctc actcccagcc ccagctgctg gccttggctg cagcctgggg gagctgatta 28440caggctctct gtgggtgggg aaggaacagg atgctctccc ggtggtcaga ggacaaggcc 28500aggttggggg agcgaggctg tggggagggg accagcatca ctggggccgg accacctccc 28560caccgaccgg cccccgtcat gtgcacctca taactgctag aaagatgtgg agagtggcca 28620ggctcagtgg ctcacgtctg taatcccagc actttaagag gccaaggcag gaggatcact 28680tgaggtcagg agtatgagat cagcctggcc aacatggcga aaccgtctct attaaaaata 28740caaaaattag cctggtgttc tggcacatgc ctgtaatccc agctactcag gaggctgaga 28800cagaagaatt gcttgaaact gggatgtgga ggttgcagtg 2884021124PRTHomo sapiens 2Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 1 5 10 15 Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 20 25 30 Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Ser Gly Asp His 35 40 45 Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 50 55 60 Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 65 70 75 80 Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 85 90 95 Val Leu Leu Tyr Arg Ile Arg Ser Phe Tyr Phe Pro Asn Trp Phe Gly 100 105 110 Leu Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala 115 120 125 Ile Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser 130 135 140 Asp Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln 145 150 155 160 Gly Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg 165 170 175 Glu Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys 180

185 190 Ala Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe 195 200 205 Val Thr Arg Arg Ala Ile Arg Arg Thr Val Arg Arg Ala Leu Pro Arg 210 215 220 Val Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile 225 230 235 240 Met Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His 245 250 255 Val Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Phe 260 265 270 Arg Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Val 275 280 285 Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 290 295 300 Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 305 310 315 320 Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 325 330 335 Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 340 345 350 Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 355 360 365 Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 370 375 380 Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 385 390 395 400 Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 405 410 415 Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 420 425 430 Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 435 440 445 Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 450 455 460 Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 465 470 475 480 Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 485 490 495 Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 500 505 510 Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 515 520 525 His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 530 535 540 Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 545 550 555 560 Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 565 570 575 Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 580 585 590 Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 595 600 605 Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 610 615 620 Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 625 630 635 640 Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 645 650 655 Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 660 665 670 Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 675 680 685 Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 690 695 700 Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 705 710 715 720 Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 725 730 735 Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 740 745 750 Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 755 760 765 Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 770 775 780 Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 785 790 795 800 Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 805 810 815 Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 820 825 830 Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 835 840 845 Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 850 855 860 Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 865 870 875 880 Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Glu Pro 885 890 895 Glu Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 900 905 910 Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 915 920 925 Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 930 935 940 Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 945 950 955 960 Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 965 970 975 Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 980 985 990 Trp Tyr Ala Pro Glu Ser Leu Ser Asp Asn Ile Phe Ser Arg Gln Ser 995 1000 1005 Asp Val Trp Ser Phe Gly Val Val Leu Tyr Glu Leu Phe Thr Tyr 1010 1015 1020 Cys Asp Lys Ser Cys Ser Pro Ser Ala Glu Phe Leu Arg Met Met 1025 1030 1035 Gly Cys Glu Arg Asp Val Pro Ala Leu Cys Arg Leu Leu Glu Leu 1040 1045 1050 Leu Glu Glu Gly Gln Arg Leu Pro Ala Pro Pro Ala Cys Pro Ala 1055 1060 1065 Glu Val His Glu Leu Met Lys Leu Cys Trp Ala Pro Ser Pro Gln 1070 1075 1080 Asp Arg Pro Ser Phe Ser Ala Leu Gly Pro Gln Leu Asp Met Leu 1085 1090 1095 Trp Ser Gly Ser Arg Gly Cys Glu Thr His Ala Phe Thr Ala His 1100 1105 1110 Pro Glu Gly Lys His His Ser Leu Ser Phe Ser 1115 1120 3140282DNAHomo sapiens 3gtgtgatggc acgcacctgt agtccctgct actcaggagg ctgaggcagg aggatcgatt 60gaggctggga ggtcaagact gcagtgacct gtgattgtgc cactgcactc caaagcaaga 120ctctgactca aaaaaaaatt atttgcatga aaaacttcat tcgttatgaa gacttgtata 180gaaacattga aatacactta tgaattacaa ttaagtttaa ggaacagttt acaaagtgac 240atgtatgcca tgactatatt tatatgaaaa atatgccccg tggaaaaaga taatgggaag 300aaaacatata atatggtgac tgatttatat caggtttgca agattacagt caattttttc 360tccagattcc aatttttgga aacaaatttc atgatttgta caatggggat ttagtttagt 420ttagtgttgt tgaaaaaaca tcattgtttg catctaacat attttcccat tgttatctaa 480gcaatagctt ttgcagagga agactgatgg ggacatattc ttttgatgaa gatttatgtg 540tgaaactgtg tgtatgattg atggttgggt ggttgttatt aattttctaa taagaggctt 600ctacactgca tttggtttaa ttaaatttag atgtatgtca tggattgcat gttagaagga 660aatatttgta ttcttttgtt ttacactatt gtgtctctcc tatatatcat atattctact 720gagtggcatt tttttttttt tttgagacag agtctctctg tcgtctaggc tggagtgcag 780tggtgtgctc taggctcact gcaacctccg cctcccaggt tcaagcggtt ctcgtgcctc 840agcctctcga gtagctggga ctacaggtgc atgccaccac gcctggctaa tttttgtatt 900tttttgtatt tttagtagag acagttttgc catgttggcc aggcttgtct tgaactcctg 960acgtcaggtg atccacctgc cttggcctcc caaagtgctg ggattgcagg attacaggca 1020tgaaccactg cacccggccc tttttgtttt gttttgtttt tttgagatgg aatttttctc 1080ttgttgccca ggctggagtg cagtggtgcc atcttggctc actgcagcct ctgccttccg 1140ggttcaagct attttcctgc ctcagcctcc cgagaagctg gaattacagg tgcccaccac 1200catgcccaac taattttttg tatttttagt agagacgggg tttcaccatg ttggccaggc 1260tggttttgaa ctcctggcct caagcaatcc accccgtctt ggcctcccaa agtgctagga 1320ttacaggtgt gagccactgt gcccggccgt tttttttttt tttttttttt gagacagggt 1380ctcactctgt ttcccaggct tcagtgcagt ggcaccatac tagctcactg cagccttgat 1440ctcctgggct caagtgatcc ttccacctcg actcctgagt agctgggacc acaggcatgt 1500gccaccacac tcagttattt tttgtatttt ttgtagatac agggttttgc catgttgcgc 1560aagctggtct cattttgaac tcctgaaccc attttgaact cctgaactcc caaaatgctg 1620ggattacagg tctaagccac cacgcctggc tcagtgactg tttaaaactt tcctcttctc 1680aaacataaaa ctgaatttct tatcctgttt agtcggtggc atccagtcgg tggcatcctt 1740ggtcagctta ttaaccaatt cagaaaattt gggagtcatg cgagattcct ctctctgcct 1800cagtagccac atctaatcag tcaccaagca ctgtccattc tatctcctca ggccttttgc 1860atcttcctca gtatccttcc ccagtccact gccttagata ggctgtcatc tctcgcagct 1920tgcagtttta caatgacatg taattaatct ccttgccctc caattcatct tccacattat 1980ccctagacta gtggttctca gtggggtgtg attttgcacc ccaggggaca tttggcaacg 2040tctgaagaca tttttggaag tcacagctgg gaaaggagga gggtggggag ttgcgggggg 2100gtgtgatggg ggaacaagag gacttgctac tagcacctag tagtcagagg tcagagatgc 2160tgctaaacat cctacaatgc acaggacacc cccactacaa caagaatttt ccagcccaca 2220atgtcaatag tgctgaggtt gagagccctt gccctagggt gattcttcta aaacaaaaac 2280cttaaatctc tcaaaaaaaa aaacccacta ttttatttta ggcaaaagtt tttgcatggg 2340attcaacttt tctcattccc cagtcacaca gcatatactt attttttttt tttaagagaa 2400ggggtctcac tctgttgccc aggctaaagt gcagtggtgt gatcctagct cactgcagcc 2460tcaaactcct gggctcaagt gatcctccag catcagcctc ccaagtagtc ggaaatacag 2520gcatgtgcca ccatgcccag ctagtttacc tttttttttt tttttttttt tttgagaggg 2580agtctcgctc tgtcgcccag gctggagtgc agtggcacaa tctcagctca ctgcaaactc 2640tgcctcccgg cttcaagcga ttcttgtgcc tcagtctccc aagtagctga gattacaggt 2700tcccgccacc acgtccagct aatttttgta tttttagtag agatggggtt tcgccatgtt 2760ggccaggctg gtctcaaact cctgacctca agtgattggc ccacctcggc ctcccaaagt 2820gctgggatta caggcgtgag ccactgcacc tggcctttgt ttgtttgttt gtttttattt 2880tagagacagg gtcttgctgt gttgcccaag ttggtgtcaa actcctggcc tcaagcagtc 2940ctcctgcctc agcctcccaa agtgctgaga ttacaggcat gagccgccac acccagccag 3000catatactat tactgcctga atatgccgct acctcctgac tcctgcctcc tgtcggctac 3060ttgaagctta ttctgacttc ctcagactcg gctgggtgac tgtcttctgt gatcaccatt 3120acaggaccgg gaatcactga attgttactt gcctgtctct ctgactgcat tgagcattca 3180gaggtcagga acctagtcta tttttttttt ctctgaatct tcatcaccta gcacaatgtc 3240tgttatagac gaacagatct aaactgaatc caggccctct ccccctgatt ccaccctgtg 3300aacagccaga ttcgttcgtg ggcacaatgg gttcactgct gccttcctga ctttcctttt 3360tctttacatc ctcacctgaa atgctgttct ttcacgtctc tgtctccctt catgtcagtc 3420tcacctgttc tttatggtcc agctcaataa aaacccctac cacttcctga gcccatgcca 3480tgtgggctat attatcatag ttcaccttca gcaaaacccc tttaaggaag gcattatccc 3540tatttaacag gtgaagaaaa tgatgcaaac agccctgagg tgttgttcag agtgtggcag 3600atgagacaag acttgcacac aaacacccac aatgcaggca acccgggttg cctccctgtc 3660tgctctgatc tccggtcttc tttggtcctc ttttctgtac ttctggaagg cactttggag 3720atccttttgt ctgctgctcc actgagaatt gagtcaacta agaattgttt agggcaacac 3780aggtggttac tggtggaggc caaacctcaa attcagtagt ctaattcgga tgcttgactt 3840tattccacac ccagaatatc ttgctcagtt tcagttgcag taactcaagt gatcaggaac 3900tgtccagcag ggttagtgaa gtcagcacag gtggggcagc ctctgtccac agccctgaag 3960ctgcagaatt ctgaccgtgc acggcctcgg aggattttca tccagggatt gtcaggggga 4020agtcgctgga gtgttttaag catgggagtg tgtggaacag atttgaattt ttaaaagttc 4080attgtagaga attaattggg ggctggagtg aatggagtga cgatttaaga gatgttcgtg 4140gtcccttcag gtgagagatg gtggcagctc ggaccgtgtt gccggaacat agacaagtga 4200actgattgga gagataccta aggaaataaa attgttagga tttgtccgtg gactgcctac 4260gaagtatgaa tcttggctac agtgtgacct tgattaagac actaaagact taatttgttc 4320ctcatggata agatgatgct actactttga gaggttatta gtaaaaaatg aaaagcgctg 4380tacatgcatt aggtatcagt gaatgtagtt ctaattccta ttatgcatat gctttttttt 4440ttttcgtaaa gagcttttaa aatacggaat gggttggatc tgcagtagct tgtccaagct 4500gggggctgta ttgttaaatt ctttttagtc tagtgctcca ctagctcctc tcctactgag 4560ctggggtaag aagcggagcg tatacggagg aggcgggatg catttctgca tcgagcgcac 4620aaaggtgtgg cggagggggc tccagagctg ggaggggtca atctacgggc gaatcctggc 4680aattttactc cccgcgatag atgacctcgc gtcctagatg agtttctaga ttctagaatc 4740tagaggacgc ggtgaacaga gacgagtggg ggcagcttcg cgagcgaagc cggatggggg 4800cggggcgggt aggccggagg cgcagagtct ccgccgggac cgcgaccccg ccccgctttc 4860cggggctgcc gctggtgacg tcgcgagggg gtgggcccgg cggccacggg ggtggggccg 4920gccgcggggc ggggcggggc gggacgggag gcggtgcgtc gctgagcgca ggccgcggcg 4980gccgcggagt atcctggagc tgcagacagt gcgggcctgc gcccagtccc ggctgtcctc 5040gccgcgaccc ctcctcagcc ctgggcgcgc gcacgctggg gccccgcggg gctggccgcc 5100tagcgagcct gccggtcgac cccagccagc gcagcgacgg ggcgctgcct ggcccaggcg 5160cacacggaag tggtgagtgt caccggggga ggtggaggag ccggggcggc cgcggtcggc 5220aggcgagggg cgcgcagccc ggactggccg gaggcgcggc caccgctctt ggtcggtcct 5280taggctgcgc ggcccgggct gctcctgagc gcagctcagg accccgcggc tcgggcgggg 5340aaggcgggga tttccagccc cgcggagccg gcgggcggcg aggaggtcgc cgggcggggg 5400cccccggccg ggagaagagc ggttaagcca ggccgccccc tcccccagcg cgcacggcaa 5460gttttcataa acaagcccgg agcgcgctgt ctgacatcct gtttatacca ccccgagata 5520caggcgcggg ctggagggct gacgtcccta gctccttgta ccgcgaactt gaccgccagc 5580tcccggccgg ggtggcagcg cagaaaggtt ttcttcttcg gccccaggaa ggaggctgag 5640ggtcttagct tttttccttc cttgcggtct cagcgaggga aagtttctgg gatttggagc 5700tgggtgttgg gcgtccgcga actcgggaaa cgccccctcc cctcttaggt tctgttagga 5760accaggcctc aggtagccag cgagaagtgg gaaaggagac cctgggcgag aggaccaggg 5820aaggggaaca gtgggagaga actacccggg gaattgcgaa tcccactgga aagggactga 5880ttaaccgaaa ctggggctgg tctctggctc cctcactcca actccatccg cgcatcgtcg 5940gcgaccggga gcatcggagg actaatagac actcctccaa agtcactccc cagggtccct 6000gggatgtggg ctccttggat gtgtgtttac cacggaactt ctagataaaa gatgcgatgt 6060ttgccaggtg tttgtgcaca cgttttttgg agggtttgca ctccatgatt tcctgtgtgt 6120tcctggggaa ggggaccccg tccttcctgc cactcttctt actacgtggc tgtgagctgc 6180cttctgcccc tggttgagta catcgctata catgtcattg acacttttcc ccccaagtca 6240tagggttttt ctctcactgg caggaattta cagtggtata aaattgtcat tacttctttc 6300agggagtaaa acatgggtag ttaagtgatg agaataatgc agagagagat gtaaatcagg 6360gcgtgtttgg ttttggctat ttttttattt tttgaagaaa agatttgagt taaatatggg 6420tataggcaca gtagattttg tttaagatga gcaattcgta ttgattgaat ctttgttctt 6480ccctttccaa aaccccatta tgtgttgttt cttgattttg cttttggtga ctctgatgtt 6540ttccaagacc aggggattat tttcattgaa ggatcaatgt gttcttttgt actttgtggt 6600gaagattaat ggagaccacc agggttccag acatttctgg tacaatatgc tttgtaatgt 6660ggagaaaatg tctcccctgt atagatccag atcacattta aagatgtgaa gacatcatac 6720tggaatgact ttggacatta taaataggaa taatcataac ctcttcttaa ttctgtatat 6780catattaact aagtgctttg actgagtctt agtttctgca aatagataca aaactatgtt 6840tttttactgc taggattgca gtgtgatact ccacactgaa tacagccagt ttaaatggtt 6900tcctccattt catactatac taattattta ctaccattgg gaaatgattg tagagaatgc 6960ataaattaga tataggtaaa ataattcaaa catttcctaa aatataacta catttcagtt 7020gttgtaattt aggatcttaa catgagcttg gctaaagcca tatacttccg actgaaacaa 7080gcattgagaa cgtgtaggtt gatactcatt tgtgtagaga gaacaagaga acactaaggt 7140ataactgcat agcaaagacc atgatctgtg ttttctaatt ctcagattcc tctggtgttt 7200ttttcccctc aaagacacat cccattttgt atgtccttat gtcctgataa gataatagca 7260tgctgttaga agatttattg tctgagatgt gaatattcat acaaataaat ttttcttgtt 7320cattttcaca tttaaaacca ttattttaag tggatgggga attggcttat taatggaatc 7380tcgctgaaga aggaacattg gatgttctgt gattattgtg gctcagtggt atatggaacc 7440ttgtcattga acaggagtgt tggaaggaac tttcagattt ttttagacta gtaagggtat 7500gattttgcac ccaatgagat atttgcagtt tctggagaca tttttggttg ttacaacttg 7560ggggaaggga gcggtgctac tggtaggcat ctagtggtta gaggctaggg atgctactaa 7620acatcctata acgcacaaga cagcccccca tcccaaacaa agaattatcc atctcagtag 7680tgcccaggtt aagaagtcct gctttggaat actgagtaag gagcaagaag atctgggctc 7740ttgtggcaaa ttttttcact tcagggcacc tcttttcttc atttgcaaaa tggagataaa 7800aatattctcc ctggtcatct cgcagagttt tggggggaag tcaggtaaat aatgcatgga 7860aactgtgacg tgctatgcaa atcataacta atatgaagag tatttttcat aagtgaatca 7920ttagatttac cggtagttga gggaaccagg gttaaggcaa tatgttgagt aaaaagccgc 7980ctgtggatgg tttgatatta tcgaattctt tgttattcat tttttggggt aaaggttttt 8040ttagtatact tagttttctt attgtcagaa catgtacttt ttagctctat aatttcttta 8100agcaaaggtt atttttccca tcataacaat aaggagaatt cactatagaa aaattagaaa 8160atataggaaa gtagaaaata gagggaacaa gtcattcatg ctctactcgc ttgtccattt 8220aagcacactc acatccttgc caatttcttt tctataagag cagttaggat tcagagaatg 8280atgagagaga gtagctggtg accaaggaag gtgttccttg tttctgtgcc cttcatttct 8340ttctttttta ataattacga tgtaaaggta aattacatta tagtaggcat cagagacatc 8400ggttcattgt ttttattatt atttttattt ttcgagatgg tgtctcactc tgtcgcccag 8460tctggaatgc agtggcacag tctaggctca ctgcaacctc tgcctcccag gttcaagtga 8520ttctcgtgcc tcagcctccc gagtagctgg gattacaggc acgttccacc atgcctgggt 8580aatttttgtg ttgtttttta gtagagatgg gatttcacca tgttggccag gctggtctag 8640aacttctgat ctcaagtgat ccgcctgcct tggcctccca cagtgctggg attacaggcg 8700tgagccaccg cgcctggcct ggttcattgt ttttatactt tccttgctgc ctccaagcca 8760tgttctcatt cagcttgttt cctctctgct tcttactctc ccccgtgctc agctaggtgt 8820gccactgttg cttcctgtct cagaaaccct ctggttacat gggatttcaa acagctgtca

8880tgttgaaatg actgggtttc agggaccgga aactaattcc tgtgagtatt ctttcctctg 8940aggtgcacca gccttcttgg cagtttaagg cgacaggaaa gcataaaaca ttaagctcat 9000ttccgtgata cctccacttc tgagggttta tgatccatga ttctttgtag ttggcagtgg 9060gcacacattc ttccttggtg ctctgcggat aaactgccca gtcccgaggc aagacctgct 9120ttagaagcaa aaggataatt tcttttaagt ctactctggc cagaagatag agctggcgtt 9180tgttgggata tttttaatct gcagtaactg aatttattta acagtactat tcacactagc 9240attttataca ttcttttatt catttagcaa atacttgttg agctcttgca gtgaatctca 9300gagagtgaat agacagacaa caaaacaggt acaaatctgt cctcgtgtgg aatttacagt 9360ctagtggaag accctgaggg catgttcagt tttacagttg cagactatat gcatgtaaaa 9420gagtaaatct ttgtgattgt agaatgtttc ctagaaccct tcatggcact cctttgaagt 9480ttgaggacta ggaagtagct tccccttgtt atctttcttt ttttaatgtt acagattaat 9540tcattctttg tatgcacaga catctctttg gtacctatta agtgcctggc agaaggataa 9600gacatagttt atatggaaat aaacttggta tacatggctg taacacattg tgggtgatgc 9660tgtagtagca gtcagaatta agagctccag gaccctgaag agagctaatt cctgcgtgga 9720gcccttgtca aatgcttttt tgaagaggct tcatttgagt tgggccttca ggagtgagta 9780ggagttcctt tgttttaggg tgggaaggaa gtctaggcag agatacagtg tgagcaagga 9840cataaaagtg ggcatgtacg tggtgtcagt ggcagacttg gaagtggcca ctagattaga 9900gcaaagactg cttgggaggg agcggaagga ggtagggcag gacatgcagg ttggatccag 9960attgtgaaga ccgtagctct ttccacaaat ttgtgagcag tgttaggtta gggactgagg 10020cctctgttga acgaatgagt ggggaagatg agaagccatt tgaagtttcc aagctcaaga 10080ataacatcgt tagcaaatga agacctgaag cactgagagt tctatgaagg gtgagcttca 10140tctgaccatt gtgcaactct ctcctcccca tcccagaaaa cgccttttat tatctgccat 10200ttatcaacta tccagaagac tactaggaaa caagaaaggc ttcgagccaa gcaagatgtc 10260atgaagttca tccatgcttt tcttacagtg gaataaaacc tactttgatt tgcttttaat 10320ttataaagac ttttttttga cagtttatct aactggtttt taagccatta ggaaattaaa 10380tacaagaaac ctaagaggca agagttgtta agtggatgaa tacaggaaga catgttctca 10440gaggcaagca gtgttaattt ttatcttaga agtgaataag gagtttctac tggtttatga 10500caaggagaac caaaactcaa aagtgaaaca atctggggca tttagtggag ggcaaacacc 10560attgtcaaca agctagcaat ttgaggttgc attgttaatc acagcacagt atggtgtttg 10620gtattggtaa tgatcatcaa gccatgaaga agaggtcaag ttgttgagca taaatgaagt 10680gaaagttcac atctctagca gaaaagggca acttcagatg tctcatttag gggttaggag 10740gtatgtaaga aggtctgagg acaatataag aagctgcttt cagagaattt ctgtagacaa 10800attcaaagaa gaggttttct tcagggtgaa acaccagtga ggaatctttg ctttaactca 10860gggaagatta cttaagagtg agctgcgaga gaaggttgac tgtgaaacct aggaagagga 10920gctgcggccg tctgcataga agatagtaat aacttgaagc cggctgtagg agactaaatc 10980acatcaattt atggtacctc tgagtagaaa acagactgat tgattgtctt ttagccttgt 11040tttgtttttt gattctgata gtctgttttt ggaggctctg gatctacact gtatgatttg 11100atcctagctg tgagtttgca agcaagttac gcctgtttcc ttatccatag aatgacaata 11160aagacagtac ctacctctga ggttgttttg agggttgaat gactatgctt aagattttga 11220agtgatgcca gcatgagctg aaaatgtgct agctattttt acattttatt ttattttgag 11280acaaggtctc gcgctgtcac ccaggctgaa gtgcagtggt gtggtcataa ctcaagtcag 11340cgttgacctt ctgggctcaa gcaatcctcc ccacctcagc cttccgagta gcaggaacca 11400cagacatgtg ccacaatacc cagctaattt ttaaattgtt ttgttgagag aggtttcatt 11460ctgttattca ggctggtctc gaactcctgg gctcaagcaa tcctcctgcc ttggcctccc 11520aaagttttgg gataataggc atgaaccacc atgcctggct tattttattt taatgattga 11580taaataggat gtgtatttta aaaaaaaccc tcaaattata ttcagaatgt ttaacatagt 11640agggaagatg ccaccagtag atacaaaaca aaaactaaca gatatattct atgttagatt 11700tcagttagca atgagtaaat caaaaaagaa ggcagtttct caaatctaga agggtttatt 11760acgtagacag tgccaaaggt gctaggtaaa ttaggtttta ctcttatttt taaggaaaaa 11820tgactaacaa aggtgctttt atttaattta aagtgccatc caaggtatat aatttggtag 11880gaatgtattt gactttctgg gaaagttaat gtgaagatac tgtgttgacc tcactgattc 11940agtttactta gcaagttgtg ggctattggc agaggcacca tgtatacctg tttgtaaaac 12000ggtgtcttca gagttgtgtg gaaattaaat atcttgtaaa tcagataata ctccagggag 12060ttttgctggt aaggaattat aagagtttaa agggactctc aaatatgtat tcagtttcta 12120tggaatgccc ttttacagtt tctgtttcca taaacatatt ttgctttcct aaagcaagat 12180ttacccaaaa tgtaaaagtg tgcaaagagt tggcccttcc tcctaatcat agatgtgtgt 12240tttaaaatat tttaaatgta tttccttctt ggtgatgtat atgttggact ggtttcttgg 12300gtctgggcat tatttatact caagaacagt tgttgccacg tgattggaaa agcgctattg 12360atgtcattct catcccatat gctttgacag caaaggagtt agctgtatct tcccttgtct 12420tcccactcta gaatgagaaa gacaagaaag ctccctaatt tgatttgtat ggagggggag 12480tgggtaggaa agtccacttc agctgaaaag gctgacctgt aggtatttaa aacataaatt 12540taggtctgtt attttcacat acacttggta actcagactg gtctgaatat aaagtagaaa 12600tagctaagaa ccatttgtaa tgaatgcaac tcttatttgt ttttaatggt gttttaagga 12660cttaagggta ttagaactga caacagttta ttcagttaag cacaatttta tctggaggct 12720tgcttgcaca gttaatttga tcaggttgta gtaaggctat ataacagttt ttttcaatta 12780tgatttaaaa taatgtttat attgtactaa gagaaaagat aacagaaaac aactcaagga 12840aaaaataatc tgccaaatat gtgtctttcc agataaaaat tttgttatta aactagtttg 12900gtggatcaca cacagggatg cggacagatg caatatatat tataaagaaa gaagtacaat 12960ggctttttgc caggtgtacc tgcaaaccca ttttagcact aattcacata acatagacta 13020aaaagtaata tgctaatgtc ttaatttaat attctgactg attttgttca gttaaaacca 13080ttctgtaaaa cttaaggcaa gtccacgaat cacagtatac gggttatctt tttgggaaaa 13140tcatttgatg tatggtggta actccaagga acctcatgtt tttacttgtg tagaacgacc 13200attcacttgg gttggttgga agtaggaaga agtcagagga ggtcatattg gcccaaacat 13260aaattgtaag cccacttgat gtgatttagg aagcaggcca cctaccatct acaagctggc 13320tgaaatacaa atgctcttag gttttcatgt ttgttccttt attcagcaac tctctgtaga 13380tctcactgta tgtgagaaca agatgggctt ggctcctgcc cttagaaaag ttccttgcta 13440gttgaaaaaa caattcagca attatattac tgtttgttac agtgatgctg agtaccggga 13500gagatgtcag aggtgggttg taagaaaagg gagtctttgc agtacacttt tttttttttt 13560tgagacggag tctcgctctt tcgcccaggc cgggctgcag tggcgctatc tcggctcact 13620gcaacctctg cctcccgggt tcacgccatt ctcctgcctc agcctcccaa gtggctggga 13680ttacaggctc ccgccaccgc gcccggctaa ttttttgtat ttttagtaga gacggggttt 13740caccatgtta gccaggatgg tctcgatctc ctgacctcgt gatccgcctg cctcggcctc 13800ccaaagtgct gggattacag gctcccgcca ccacgcccgg ctaatttttt gtatttttag 13860tagagacggg gtttcaccgt gttagccagg atggtctcga tctcctgacc tcgtgatccg 13920cctgcctcag cctcccaaag tgctgggatt acaggcatga gccactgcac ccggcctgca 13980gtacactttt atacatggaa atctgaagtg tgaaagagct gtgccaagag aatgaggagg 14040atttccagtg agaggcacga atatgtgcca aagacctatg gtgggaccaa caccctgcag 14100ctggtgcaga gagaacaaag gtggaggctg gtgaggcagg aaggaacctg gtcaagcagg 14160gccttatgtg ctttattact tttgggcctt ataatgcatt aggggaagtt gaagttttta 14220agcagggtag taacatgatg agatttgtgt cccatgaaaa aacggaagga tcccatccac 14280tcactgttgc ccctagagca cctctcctct ctttcctctt tcccttcatt ctgctgccaa 14340ataccttgaa aaccttcact tcctcccacc cactcattct ttaacccttt gcaaactgac 14400tgccacctct acactcatga gactgcttcc ttgaggtcac cagtgacctt cttgctgtca 14460cattttaaca ccttttttct gccctagtta tctaaaacag ttcatgctgc tgaaaacctc 14520cttcctggca gatgtccctc aaccctactg gtgcctggct tctgagacac agtaaggact 14580tcctttctct gtatgtctct gttctctttt tgagtatcgt ctctttctct cacttctcct 14640cctcccccaa tgaggatgtt tctaaaggtt ctgtgaatgg tagatttata tgttgcgaaa 14700actgtgcaga tgacccactt ttgcctgagc tccagttgtc cctttttatt tattttcctt 14760cctctctgct ccttacctcc cccaaatact ggttgcacag tttcagacac tattcaaggc 14820actggggaca ctggggaaca agagaggaaa ggtccctgtc cttaagtagc caacagtcta 14880agatgttaaa cacattgata aacaagataa tttcaggtgg tgataagtgc aatagagaaa 14940gttagcaagg tatgggtagt gaatgcttag gttggggggt tgggagaagg gctcctggtc 15000tgagaaagtg acatttaaat tcagccctga aggatgagta atgagtagaa gccaggcagt 15060gcaatgatct gtaagaaaaa tgtactaggc agaggggata gccagtgcca cgccccttca 15120gtgggatgag ctttccattt cacactgggc tgccttgctg tgtgtccttt gacacctccc 15180atttaactgc tccaagattg ataccgtctt tctttctgac ccatcatcat aataatggat 15240gatttctctg ttttggttaa taccgtctct atccaccacc ctgaaaaccc taggccagca 15300gtctgaaaac tttgtgaggg gaaagacagt aaacattttc agctttgagc acagtacagt 15360ctgtcacaag tactgaatct gctattgtag caccaatgta gatatagaca gtatgtaaac 15420caatgagtgt ggctgtgctc caatacaact ttatgtatgg acactgacat ttctattttc 15480acttgtaaca aaatattttt cttttttttc caaccattta aaaatgcgtc agcttattgg 15540cgttcaaaat gggcagcggc aggccagatt tggctcacag gccaggatct gctgccccct 15600gccttagact aaccctgatc tctccctttg cttttgcccc accccacctc ctccctaggc 15660cctttcaggg ctccctccct ggtattcgta ttcagcacct ttgccactcg ctgtccccac 15720tgctgcagcc ttcctttggc tttctttacc tgggtgatct atcattgcgc actctatgtc 15780catgtgcaga cattatttag ctcccacttt aagtgagcac atgctgtatt tatctttccg 15840tgtctgacta ctgatcacaa gcctttagaa gcccctattg cctatagaaa acaatccaaa 15900ctccacctta gtctgatagt aaaggttcct tatgctaaaa cctcagttta actttctagc 15960atactctcct atttctctcc ttctacactg tcccaaaata gattattcat tattttgctt 16020tcaatgtttc ccatgctttt ctgtgttctt gttcatttaa tgcacttttc ccgtgcttca 16080tgctttccat ctgtcagaat tccatagctt tcaaggcccc ttcaaatgtc cctggtctct 16140tcctctgccc ctccctaccc caacaagcgg tgtgtataca catagtcccc tggtggtgtg 16200tgatcctctg ttccagtacg tcgtgttctg gtctgtgctt ctgttctttt gcagacacac 16260ctccactatg cagtcacgag gcccttgagg acaggaacca tctctttctt cgtaatgtca 16320cctttcccag taggcacacg gctgtttatt gaataaacac agatcctgtg tacacttgct 16380caaattgtac aaaatttgca ggagattcaa agtggaaaca ttttactgaa gggaattcgg 16440tcaaattaca tccttgattc ttgtataggt ggtacagttt tgtaaaggat catcaagtat 16500tttggaagac tcattggctc tgccagtggc ttagataaat aaattcgggc aagttattga 16560tctctctcct cagagaaaaa aattgatgtg ttttctttta tataaagaga aaaagaaaaa 16620gaaaaaatgt gatctgtaac tcattatgtt tccttgctag aaagctcaaa gatacgttat 16680ttgcctgttt ttagttgcta tccagttttc ttacaataat ctctctgcct cagtctcctc 16740atcggattac ttgtcacatg tgttaaatcc ttcttttaat tgatggttct gttgtatata 16800tcttttatat ttatataggt agcctcaact ctcctttttt tggagagtgg taatagaaat 16860ataaataata aatagttgcc ctttggtttc cccaacctgt ggtgacaaca agataataaa 16920acagatactt atcctatata aaacaggcaa aaaggctttg ggacaatatg ggaatcatga 16980tgtgggtttg gtggaaaacg agcaaagcac cttgtaagga tcttgtagtc tgaagattaa 17040ggtgtgcttg gggtaggtca tgtcctccca gctctgtggg atttgtagca catcatccca 17100cgtggggagg agagtgggca cgggcatgag actatttatt agcttttact gtgtcagttg 17160ttgggttatg tattttgcat ttgatattta atttaatctt tgtaatagcc agagacttgg 17220atcttattgg catcattttc cagatgagca gagctaataa atggcagaac tagaattcaa 17280atctgaggct ctctggcatt gaaaacaaca acaaaacatg tttctactct tcaaagagac 17340tttttctcct ggattgtcac ttgtcctttt ctttctcttt ctctcctgac attggtattt 17400aaaatgagaa cctaggaaac ttgtttcttc taacctaatg tttttgaagc agttttaggt 17460ccttggagat gtgccttgat gtgtctatac aatatagtat ttggtattgt tagatataaa 17520gaagacctga ggccgagtgc ggtcgctcat gcctataatc ccagcacatt gggaggccaa 17580ggcaggcaga tcacttgagg tcaggagttc aagaccagcc tggccaacac agtgaaaccc 17640catctcttct aaaaatacga aaaaaagaaa aaaagaaatt agctgggcgt ggcagcacgc 17700acctgtaatc ccagctactc aggaggctga ggcgggagaa ttgcatgaac ctgggaggca 17760gaggttgcag tgagctgaga tgatgccact tcactctggc ctgggggaca gagcaagact 17820ctgtctcaaa aaaataaaaa aaaatttttt gttttttagg ttttggggca gggcagttgg 17880gttcatttag ctgtcctaaa gtaagtttgg tatatttttg tgaaatattt agtttaaaag 17940ttgtattgct gtttttgaca ttttaagtca gacgagattt actgttgctt tatattacct 18000gactgttata taacacgtcc tgtgtttacc tgtgtgggtc tgagcgtacc agatgtggtg 18060ttatgaaaag cgtgctggac ttggaaccag gacgagccga tgtgaggctg tcctctgcca 18120cttactagct ctgtgacttt gggctcataa ttgagcctta tttttttctc aattgtaaat 18180ggactgtgta gacctgtcac agaggaagtt ttgtgaagct taaatgaggt agaacctaca 18240aaatagcttc agacagtgcc tgggatccag cagcatttaa cgaaagttac ccactgctac 18300cccaaatact gaatattgcc agaaaatctg taaatgatta cataatgttt acacctttat 18360aagtggtaac tttgtaggta aatattattc aagttatgaa cctctgattt aggaaacctc 18420cttatgcaaa tggttggctt cccactacag aaacatcagt aataagatag tggtttagac 18480tcccaaatct gcgaccagtc tgtatgtttg aatcctggct tatgatcagt catagctgag 18540tgatcgtggg caagttattc aaccgctttg tgcctcagtt tcctcatctg taaaaggata 18600ataggataat aatggctcct accttatggg attgtgaaaa ttaaatgaga atgtgtgttt 18660atgtatgtgt gtgtttgtct gtatttgtac caatacccta ttggagttta ccactattat 18720ttactgttcc tcttctcttt tcctccctgt gtaaacagcc ccataagtta tctggaagtt 18780ccctagtatc tctttcttat cttctgttac tggaagactc ctttttcttc tgtctttggt 18840cccgtgttag ttgcttcatt ttaattgagg ctatcttgtt ctagtgtgca atacattctc 18900attgatccct tccctataca tttcttgcct agacactttg aaaaagtgtt tttgttttgg 18960gtggaaactg aacattttct aataatgact cataaaccca gccaggtgtt aaggatactc 19020ctatatcaag gaaaatgaaa gctatacagt ctcaagcaaa tgaaaaaact atataaaatg 19080cctaattgtt tattgaatgt ttatgccaga aattcagatc aataaactga gccttagaat 19140ggttgatgtt taaaggtacc cggcttttaa gtggaggaac ctagatttga tcaaagccag 19200accaacctgg cccttggttt cacaatccct aagctcactt gccttaataa ggcctctagg 19260caccacctca agactccatc tgcacccctt atgaacctac actctgcttt ccctcacact 19320cctgcttttg agatggcaaa atcacttatg gttctttttg gctgcagtaa tgtttcctgc 19380tattttggca gggcaaatgt atagcgtttc agatacttta tgtgttaaat tggccttttg 19440tgtgttggct tggaaactta accacattta ctgcagtgtg tctgggggaa atgtgcgcca 19500agtttcaaac aaccaactgg gaatgaattc tttaaaaggc agaacttgtg cctggcgcgg 19560tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggcggatc acgaggtcag 19620gattcgagac catcctagct aacacggtga aaccctgtct ctactaaaaa tacaaaaaat 19680tagctgggcg tggtggcggg cgcctgtagt cccagctact cgggaggctg aggcaggaga 19740atggcgtgaa cccgggaggt ggagcttgca gtgagcagag atcgagccac tgcactccag 19800cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaggcag 19860aacttgttta tagctaaggg ctgctggtgt atttatttga gtgtgttacc tgcattggta 19920tgctttaagg gcttctgtgt catgcctgaa gcgacatatt ctggaatgta tacattattg 19980cacttccttg gttaattgtc ctcactgttg ctgacctttg tacactgaac cactgccatt 20040gtgtttggca cgtagtagga accctgtgaa gagacttatt tagtcctctt taaagatcaa 20100tggttcttta tacttttctg tatgcttgat atatttcaat ttaaaaaaat cagtggagta 20160aggaaggatc aggcaacatt gaaagaggaa tattgccaca cagttgccaa tctgatgaaa 20220atactgctta tgctaggtcg aattgagact ctgaaaggta tttgggagcc agacacttat 20280gagaatacat attgctttga atattggaag aaagcaaagc agtcaaacga atttcttctt 20340ggcttggagt tttgtttact tttctcaggt tagaattgat agttctaatg gttttaagaa 20400gtcatggaga acaggcccac catgaacctg aatatttggt tctgagttta tagccattgt 20460ctagtaaata ctgtttaagg gttattagca cacaatgatc ataaaatctt gtaatacttt 20520taagaggtgt aagaaattga agtcacctga gaatacctcc ttctgatttt acagtggaga 20580aataaaggaa tcagagtgtt taagtgactt gcctaagacc tgtctgggcc accactttag 20640ggattgtttt ttaatccatc atcatgctgg atttgttact gagcgataaa atggtacaga 20700aggtagtcac atagagaatt taggaaataa aatactcatt tgttcaaata cttctcagga 20760ggttgagata tatctatggg tagaagattt agaggttatt taagagaaat taggattgtc 20820tagggtccac cccttaccgt ggggattctg aagggcagtg tcttatgaga gaagagagat 20880caagttactt ggtgagtgag atgttctagg tgctcagtcc aagggctggc cggatggcta 20940gcactgaact tgtgtggatg tttgttcaaa ctaatcagcc tacgattggt ttgttcctaa 21000gaatgataaa actttgttct agttttttaa attgtaataa taattctgta agcatttaag 21060aagaatgctt tctttaatgt tgactttttt ttttttttga gacagagtct tgctctgtct 21120cccgggctgg agtgcagtgg catgatctcg gctcactgca acctctgcct ccgggttgaa 21180gtgattctgc tgcctcagcc tccagagtag ctgggactac aggcgcccgc caccacgcca 21240ggctaatttt tgtatcttta gtagagacgg ggtttcacca tgttggccag gatggtctcg 21300atctcctgac cttgtgatcc gcccgccttg gcccgccaaa gtgctgggat tgcaggtgta 21360agccactgcg cccggcctaa tgttgacatt ttttactcct acacgaagct gttatgtttt 21420tacttattct tttctagtct ttatcgataa tgtataaata tgtactgtat tatgtaattt 21480taattgctgg atacatatac ctgtcttctt aaactttttt attctatttt aatagagtct 21540ttgtaataat catttttgaa tgtagtattt agttgtgtta atttatttta tttttcttaa 21600gtaatctatg atagaataag ctatttctgt ttttacagaa tattgtaggg aacctttaaa 21660aacacacaat tagcattttt ctgctgctaa ttgctttatt aggatgaatg catagattta 21720ctgtgtcaaa ggttataacc aattttatga cctttagtat gtaattctgg aaaattaaac 21780agaaacttaa gtcacaaatg gccttaaaca ttggcaggaa gctgctgatt tcctgactgt 21840tgtacaggca acccactggc aagtaacatg tcaaatacgg accattataa ttccttatca 21900taaaggcaga tacagttttc ttcaaaggac atgaaaataa tttatttgct tttgatgcct 21960tttctcactg ggaaatgata ttctgtaagt gcacaatgtg cacttgaatg tgaagttgta 22020gtgaggattt ttatttttat ttttgtacaa ctgggttata ataaaggaaa caaactttat 22080gtcacttcta ggctgatgaa ataccctagt aaatgcagta catttttgca tgactaatag 22140gagtaggggc ggggctttga cttttacatc agtcaggtta aaatcacctg tttgctggtt 22200tccctaagac agtgatgtat tgccctttgc ttaacttttt gttagttggg aaatgtattc 22260tactttgatg actggtgttt ttctgcttag tggggatatt ttctgtgaag ccaggataaa 22320caattctata atgcaaatct gaacacatca ctgccttgct taaaatcttt cactagctgc 22380cctttgctgt taggattaag tctatccaaa ctccttagca tggtatgaag agcctctcat 22440ggtcacagcc ttcctttcct tccattccct ttcttgcagt cagcactcca gcccttctga 22500ccgtttttgt ttcttaaata tattgtgatc tctcttactt ctaggacagt aagttctgta 22560gattccttgg tgaatataca gccttagaga ctgcaagaat tctgagcagt atttctaagg 22620gttagatttc cctccaagta ccattaacat tctgggctgc cacatttcaa gatttactct 22680ggagatgtga ggtggaagcc atgttaaatg gctggaagat agtcctgtgg gagagataag 22740ctttatcatt ttatttttac caggtgtgtt gcagtgagtg ttgaaaagcc ttccacaaaa 22800aatagagtct tcttttttcc cctgttatga ttaaattact ggctgctaat ctttcatgat 22860gaagagagaa gcccaaaagc aatttcagaa catggatctc atgctgatta gtggttataa 22920tgatttcaca tggatagtat tccttgtgtt tgaaagttat tttattggtg agatctgcga 22980aatcaacaag gctagtttat ctttgcaaaa acttgtgaca agcttatagc tacactcctt 23040ggggaacaca gttcacattt aagattttgc ctcaggcacc tctgttcagc tttatgctgt 23100gtctttcaga ttctagatat gaaactggtt tgacattaat acctagcatg atagcttttt 23160agatacactc tttgcttgca ttaagtcaga caaaatctgc agagcctagc actatgctca 23220gtatatgagc tgctttgtct gtgtatcttg gttcatacga gagtcagtat acctaggcag 23280tcagtaaaca gtcattgatt agatttggat ttaataaatt taagcctggc caataattag 23340tgggaaccaa accaaggcaa cctatagtaa atggagcatt gcatcgaaga tctcagttct 23400tcaaataagg cacagataaa ggatctctat gtattaccct cctgttcttg gatttaattg 23460ttcaaatgtt tcacccaaaa cctcaatttc aggctaatat ttaggcattc tcttctatgt 23520tatacctcag gtaatttgga aacatttgta tttctaaatc tatttctgta taaactttct 23580atgaattgta tatctctccc tctctatatt atatagtata gatttaaatt gaaaaattca 23640ttgttccctt cagaggtata agagtattct ggcccagctg gaaatgttat gttaaatttg 23700aaattctact acctaaattt tggacttgtg tactactgtt ttagtagagc tatatgatac 23760tgcagataaa gttccaaaac aatctgtggt gaaaaaattc ttgttcaggg acctgttgtt 23820cagtgaaact gcttttctgt tgggtacctg tattcttttt tggttaagtt aaaaaaaaaa 23880aaggatttat tggcctatgt cttaaggggg ttgggggagg acccatggtt catggactcc

23940aaggatataa aggcattccc cttctcagta agaatcctgc tattctgctt cctgttcatt 24000ggtcttatgt tctgccacaa tgaggtttta tccacatgat ttgaatagag aacagttggc 24060tgctccaaga tgatgtctgt ttatcaaatc tccctgaaag acttgtgttt gtgtcaccct 24120tggtctggaa ggtggacagt gcaggcatgg atgggggtca ggtgggacac tgtgatctgt 24180agtgttaaca gaatcacctg gtatgagaag tttctagaga gataaaaaca gatgtcagct 24240gtaatatatt gaactggcag ttaaaaaatt ttttttaagt tgtggaaaat aaacaacata 24300aaatttacca tgtgagccat ttttaagctt acagttcagt agtgttaagt acattcacgt 24360tgttttacat ctaatctcca gaactctttt catcttgcaa aactgaaact ctgtacccag 24420tagataataa ctacccattg ctttttcctg ctagctcctg ccaactacca ttctactttt 24480tctatctatg gatttgacta ctctggctac ttcttataag tggaattgtc cataatgtcc 24540tttttcacta gcatgtttca cttagcataa tgtcctcaag gtttatccat gtttttgcat 24600atgatggaat ttccttcctt ttaaaggctg aataatattc cattgtatgt atatacaaca 24660ttttgtttat ccatctatgt tgttggatgc ttgggtggct tctacctttt gactgttgtg 24720aatgatattt ctatgaacat gggtttgcaa atatctcgtt gagaccctgc tttcagttgt 24780tttgtgaact gccacttttt tggataactc tcatttgaaa ctatgttcat ctttttttcc 24840ttaaaaactg cccgtaatta actctttttg gtgcccagta agtggaaaat tcagaacagc 24900aaaatgtttg ctttattcaa caaacacctt ctcaaaatct agaaaacaaa gaacattaga 24960gaacactgtg gaagtaagta tgattgtggg tagctggctg acgtagaaga ttttaatttt 25020tactatgatg cataaatatg tacctttgca agttttagca gacaagagca tgaggtccga 25080tcatagacct atgactttgg ggaagttacc taaagccttg ccagccacca tttacttatt 25140tgcagagagg gggttggtta tacctgctag ggttaattag actattaaat gagataacat 25200gtgcagaaca catagccagt ggtaggtggt cagtaagtgg tttcctctct cctgtattct 25260tccaggggaa tagaagacga ccactgtgtg aggatctctg tattgttcag ctctgatgct 25320cctcctactg tgggtggtag atctccctct taacaaggct ttcttggcaa gcatttttaa 25380actttacatt ttcttatttt tttattattg ttattgatat tttgtttggc ataggtactg 25440tattgacatg gttcagaaag caaaccaggg ccgggtgccg tggctcatgc ctgtaatccc 25500agcacactgg aaggccgagg tgggtggatc acttgaggtc aggagttaaa gaccagctgg 25560ccaacatggt gaaaccttat ccctactaaa aatacaaaaa ttagctgggc gtggtggcag 25620gcgcctgtac tcaggagtat cccagctact caggaggctg aggccagagg atggcttgaa 25680ccctggaggt ggaggttgta gtgagctgag atcacaccac tgcactccag cctgggcgac 25740agagcaagac tctgtgtcaa agaaaaaaaa aaagaaagca aaccagtata acagggtaca 25800aattgagaag gtttgctccc atttttgttt gtccgtcaac ttcgttccct gtttccttaa 25860gtgctcttct catctctagg acctattaat gtaagtatat attcgtattc ttttttttat 25920tgtacataag gtaaatatat actatatact attccaccct ttgctttttt cattttacca 25980tatatcctcc tctctttcct tattagtaca tcaagtattt tctcgtgtga atagaccatg 26040acttatttaa ccagtcccca tgtaagggac attttgtttg cttctgcact tttgctgtta 26100taaatagtgc tatttgtgta actttgtatg tagaaggtca gataaattcc cagaagtgga 26160attgctgggt taaaagataa ttgcattaat aatttttatt aatattctca attgctcccc 26220atggggttag tacctttttc catgccttga aatttacata tttttgtgca ttgcagacac 26280ctctcacccc ttgctgtata ccttcttttg aactgccatc ttgttaacat ggagagaact 26340ggcaagtgca ggcgattcct tcttgtgttt cgtaagggct agtggactgt tggagtgctt 26400tccaagcagg tgccagggtt tgagattgta gtgtgatatg cgactagggg ttctgcccat 26460cccgatgtgc tcctgttccc gtctcaggac ctgaggatgg aatggctgag tgtgttgtga 26520gcccaaggtg ccaagtgctt ctcgggggag aatcagttgc tctgtgcatt aaagcagtat 26580tggctgctgc ctcccttcct tggaagtttt tgttctgttt ttttaatttc ataacttttt 26640acaaaagtta ttcctattta ttgaagactt agaatccaga gaaaagacaa aaatcacttg 26700gactctcaca acctttgtta atattttcac gaatatcctc tcaatcgtgt gtgtatcccc 26760aacataaatg gtggttatat actgcataat gtttcataac ctttttttcc atttgctagt 26820gtatcatgac tattgtaaca tctttcagta gtgatatacc cctgccccca acacatgcac 26880atgttttgtg tagatttcta ttgggtggct tcaccgtgat tctgtgttcc tggatgaaca 26940tttatgtttg tcttgttagt caacaaccct acgatgaaaa tccttctggc taaatcttgt 27000atgttattat tgtttgctta gaatacattt ctagaattag caaacaataa taacatacag 27060gaattagaac ttctaggtca aaagacatgt acacattgct ctccaaaagt gacatattat 27120ttatattcct aaatgagagt accactgtca tcatactcaa tttgtggata taataatttt 27180ttaaaaattt ccaatttatt agtaaaaagt gataaatcta tcttttactc tgtagatatt 27240taattactgg tacatttaaa cttttttttt tttttttttt tttgagacag agtcttgcac 27300tgttgcccag gctggagtgc aatggtgcga tctcggctca ctgcaagctc cgcctcctgg 27360gttcatgcca ttctcctgcc tcagcctccc aagtagctgg gactacaggc acctgccacc 27420acacccggct aattttttgt acttttagta gagacgggat ttcactgtgt tagccagcat 27480ggtcttgatc tcctgacctc gtgatccgcc tacctcggcc tcccaaagtg ctgggattac 27540aggcgtgagc cactgcgcct ggcctaaact tttttttttc aagtttgaga actcattttt 27600ttgatgtgga ttgcctagtc aagccctttg ctcattttat tactggcgtg tttgtctttt 27660ttttttttat ttattaaagc tacatatgtt aaggatatta gttttctgtc acatatggta 27720caaatatttt tcctcaagtt tacttatata ttaagaacct tttgttatag aagttttata 27780ttttcatgaa ctcacatcaa tcactcattt ctttataaag gcttctgctt ttggtgtcat 27840gtttgagaga ccttttgatg cctctaattc tacaaatatt taactcttag acttaatatt 27900tggtatattt gtcatttgaa atgataggat gtttatttta gtctatgatg taagagggat 27960tctaatttta ttattttctc tgactatcca gttgtcctac cacaaaaaat catcatctcc 28020ccactaactt gaaatccatg tttttacaaa ttgctttttt gttttttaac acattcgaaa 28080atttacacta aaactctata aaaagggcat tagagtcaca aggtcctatc cctggactgt 28140tttcaggcag ttgatgccag tgagacattg aagaggtggt ctaacctctt cttagacttg 28200gtttcttctg gggattcaca cctgaccacc aatcagggtg ttatggtcat ctgatgaggt 28260aataggtatc aattctgaac cattatatgg gaagtaatct ttatagtgct actaattagg 28320agagcccagg tattcctgag gaactataac catagtcaaa atttgatata ataaagttta 28380gttattgtct tttggaagaa ttaggaaaac taaagaaata acttctctga cttttgagtt 28440atttcccatt agccaaatag ggcctaattg taaataataa aaatgggcct gttttaatta 28500tttatcttga catggattaa atatagtatt taatttcctt aatgattaaa tatagacagc 28560aaatgtaatg ctgtactttt cacatgacgc aattcatttg gcctttttct ttttttaaaa 28620aaattaagac agttacttta tttagaacag gaaagtggtg taagcaactg agagtgtgcc 28680ctgtaatatg agaggttctt ccctcgttct acttcccacc ttaaaatata attttaggag 28740aaaaaagtat cttatatttg gttaattatg ttatctacga ttacaccttt tgctaaggca 28800ggcatggcat ttgctgatgt ttggcttgaa gtctaagaat attgtccaga tagaacatgc 28860taaattgtta catttgagtt aatgttgaat acttgaacta acatagggat gccagaccac 28920tactcttgat ttaattagag atttgtacac attttcagtt ttttccatgt aagatcagtt 28980ttattgttcc tttaaaaata ttctgatgaa ataatcttgc aaaggaaaga taacctagca 29040tcaagtctgc gatataaaaa caaaaataaa atgattttct gatcagttat catgtttatt 29100acctttacaa atagtgtatt agtcctttag agagccccac tatgctgcct gtgccaaaag 29160tgtcatgtat tgtccttgag tatcaaagtg gttcataccg gttatctagc aaagggccag 29220attgtctctg catagtactt ttcatccaga gtgaaatgat gataaattcc cacacgaagt 29280atatgtatat ctttttctcc ctggcaattc agatccatgt gtcctctata tcttttatgt 29340caaaatacct acttccatcc aagatatatc gaatttcatc attcaaatgt aaatgtttct 29400cataagacat catcttttcc tctaatttgg taatttatct ttgcatattg ttattatgtt 29460catccaggag tagtttctct ctctttggat ttttatataa ttctggatcg ttcttgtatt 29520tgtcaggaac aaccaagctg acacagtcgc tccaggccga ctgggctcca gtcggtaggg 29580ctttctctag ggctttctct ggggatctgt agtgtaaacc acacctgcct aatcttccct 29640gcttctccta gagaacactg gaaagtccca ggggacactg gcctgacctc aggcttttcc 29700tttggtcttt agattcagac atttccacta aacttagaga gtcaagtacc tggattcatg 29760ttgaaaatct gatagtagtt gactttgaga cccaggttta gtcatgtcat gtgctgagct 29820ttggtttctt cattttcaaa atgtaggccg tttgtgggag tttgaatgta acatcacagc 29880tctgaggttc cctttccatc cccagtttct ctgatagagc agaggactct gaaaggaggc 29940cagttttttt attctaacca tgggaaattt gaaataattg ttgacttctt ttgcttattt 30000tttttggtcc ctaaaatatt tgattggtca agataaatca tctttgtttt atttttcatt 30060tctgataatt atcagaataa taactggata agtcccagtg aaagccccaa ctgaaagaat 30120ttgtagtcat gttgtcacat tttatattta aaagtgtttc tctagagtta aggaatgaat 30180tttttttttc ccagatgtgg atgcaagtta caataaattc ttggcccttt tgaaccatta 30240gggattaatc attttgggtt aaccattttc tagatggtga gaatttattc ttataataac 30300cacaaaactt caactacttt attttatttt tattattatt atttttgagt tggagtccat 30360agcccaggct ggagtgcagt ggcacgatct ttggctcact gcaacccctg ccttgcatgt 30420tcaggtgatt ctcctgcctc agccttccaa gtagctggga ttacaggtat gcgccaccac 30480gcctggctaa ttttgtattt ttagtagaga cagggttttg ccatgttgct caggtgtgtc 30540ttgaactcct gacctcaggt tgtccaccca tctcagcctc ccaaaatgct gagattacaa 30600gcgtgagtga ctgactgcgc ctggccaaaa ctttaactac tttaatgaaa aaatccgaaa 30660atatattttt tctgttcttg aactgaagcg actgaataca gtttattttc tctttattaa 30720tcatgttcag ctacaaatgt aatttgtgtt gagcactgtg tttatggagc atagcataaa 30780ttggagtaga aagacctggg tttaaatttc accacctact gactcttgcc tacgaacagt 30840aaacccgtct taacctcatt ttcttcattt tttaagaaat tgaaattgag ccaggtgcag 30900tggcttatgc ctgtaacccc agcagtttgg gaggccgagg tgggcagatc acttgagccc 30960cagaattgga gaccagcctg gccaacatgg tgaaactcca tctctactaa aaatacaaaa 31020attagccagg tgtggtggca cacacctgta atcccagcta atcgggaggc tgaggcaaaa 31080gaatcggttg aacctgagag gcagaggttg cagtgagtgg agattgtgcc actgcactcc 31140agcctgggca acagagtgag actatctcaa aaaaaaaaaa aaaagaaatt gaaattggta 31200taagctaggt cttctgtaaa tgatgactct tacaataggg attccctgca ggtctgttga 31260gttatgtgta tttgcatgca catgtacaca cacggtgtat ttgttccata gtaactagct 31320ttggacttcc tgttgtgcct tctattgttt ttctgtcaac ttaccggttt tctctccttg 31380aagctatcag tatgcctgtg tgtagtgcct gctctcatag gatttatagg tttgttgaca 31440tctagttact tgtattttat acacagctct aagtgagaag gcttggcaat atgtaatgtt 31500cgtgaatatt tgtatgaaat tcagcagcat ttactttggg gaactcatat tttatgtgtg 31560cttcaaaaca atgaaactta gcactattac aacacaggag tatatttgca tcctggtctt 31620tatttataaa gaaatagtat tgagccaccc agttggggga tacacagtct aagtagttat 31680tctcttattt tgtttctggt tcccactttt attgacttat atagcacaca tacagtagtg 31740gcataatacc agctggattt cagagtgcag aatgaaacca tgtggttttc tgtgagattt 31800tttaggcctt atataggaat tatatgcatg actaggacct tataaattat gtatctacta 31860tgtgcccagc tcctagtata tacctaattt aatccttgaa caactctttt gtgttacatg 31920gtattatccc tgtttaaaga tgaagaaacc aatatttgga taaattaaat accttatttt 31980ataaatgagt aagtcttttc tgacttcaga gttcatgcat tttaccagta agccatgctt 32040tccgcttact gcaaactagt gactccaaac ttctgcaaac tgtgaaacta ttgtgaactt 32100gtgtgaatgt atggaagttg gcactgatta gacgtttgaa cttctttcct tgtcctgtgt 32160tatgcatggt aatctgccat ttgctgttcc tagctgtatg gtcaccctta gaggtatgag 32220ttgtgcttat atgtatatgt tcatgcctag atctgttgct cacagaatca tctgacatcc 32280ccatttcgtt gaatctaggc agcagggttg atggcagcca gaaaagtgtg ccctgggggc 32340aagaatgtct ttagggaaaa atatgttatt gtctttcaga tagtagttct ccaaacagtt 32400gctccaacag ttcctatgaa aagattgctt gagcccagga gttcaaggca gcagtgagcc 32460atggtcatgc cattgcactc cagcctggac aacaaagtga gaccctgtct caagagaaaa 32520gaaaagaaaa aaatgctagg tggatcttca gtttagttca gttaattaag tattttaatt 32580attaactatt aattataaca ttaagaatgc caggggagga tagagacccg tgattctgtt 32640ttggggggca ctagaaaaca gttcctgaga cactggtgct gccatctacc tctacccaca 32700tcatatcctt atgtagacat aaaatattaa gagagacttc atgaggaggc atttctcagt 32760ttcttttgta atgaactcta cttttagttg agaaacatga aagtgtatgg tttggtgttg 32820gagaacgagt ttacttacta gtttgattta cagtgaatac tgttcttggg atttataaat 32880ggttttagta ttgagaagta gaggagataa atagttctgg tgtcaaggga agcggagcaa 32940taaaatgaag ctgaaacatg accattaagc ccaagccaat cagatcatct gtgtgcctta 33000atagaaggct gatgatcttg gttcaggtct tcacttagtt catgtaataa catggaatca 33060agagttcaga caagtataaa tgcttctggg tcttgtttcc taactaggct tagtttatag 33120gccagaaaga ttctgctact atcctgttat tactggggca gtcattgaaa agagcctttc 33180tattatagtg gactgaagac ataaaatcac acagtacatc taaaaggttt catcaaagtt 33240gttctttacg aaagagtatt tttttatatc tttgtataat tgaacttttt tttaaaaaaa 33300actttttttt ttcagccatg aaattacatt ctttcttagc cttaaagact ttgacattct 33360cctttgggag gccgaggtgg gcagatcacg aggtcaggag atcgagacca tcctggctaa 33420cacagtgaaa ccccgtctct actgaaaaat acaaaaaatt agctgggtgt ggtggcgggc 33480acctgtagtc atagctactt gggaggctga ggcaggagaa tggcatgaac ccgggaggca 33540gatgttgcac tgagccgaga tcgcgccact gcactccagc ctgggcgaca gagtgagact 33600ccctctcaaa aaaaaaagaa gattttgaca ttctctgttc aagaaacttt tacagtgaga 33660gtaatttagt gtatctcaga caatgttgga gtgatcgatg gttgggtttc cttgttccaa 33720ggtagaatat caaatgttca gttgacttgt tgatggatca gtttgacctc gctttaagga 33780tatgtctgaa aaactgaaat aatgaggtca acattttcca ggtttttttt tgtcattcta 33840tgatcgacta agtctgcttt ggttttcagt tactaatcag tgttccacta atgcctattt 33900agaaacttta ttttgaaata attatagatt gacaagaagt tgtaacagag ggcctgtgtt 33960gtataattga agtttaacag tgatacgctc ctttctttct agaaaggctt tcaatttatg 34020gaaaaattag caaaggtaaa agatgctcgg cgttggacct ttgaaacttc tttcggaatt 34080agtattttga atgactccat acaactagaa taatggctga aatttctatg gtgctggtca 34140ggactgtgac tgtggcccga gcatgagatg attttcctgg aaaccaaaag tactactaga 34200aggagaagaa tgctgtggag ctctctgggg gttggagctt atgcctctgg agactttgag 34260ttttctgtgg gtgtaagttt tgcaaatggt cctggtagcc ctgaagctag agttgtcaaa 34320gtaacaggtg gtagctggga gccagcttgg cagtggatca gctacccaaa tagccaaagt 34380tgctcaatct acatgaggtc ctgtagacca aactgggggt ggggaggatt agccccatac 34440aaatagttga tccttttttt ttttttttta aacagtcatt tgaaatattt tctgtaaaag 34500gcctaagctt taggcattta ggatgattgt aaatgcactg ctttgtattc tttttcacat 34560atatttgatt tattaatata aaattgccat ttttgtacat aaaaatggtc aaatattggc 34620agtttcatat ggtacaacct actgttttct gctgtcacat tggaaattct caccaacgtg 34680ggataccatg tttcaaagaa acgttggctt agcctcttca tttatggaag aaatatagca 34740cttatggtgt tctaagtaga ttaactaact taatcttttt acaagcaaat gaggtaggta 34800ggtcctagtg ttttcctgct ttttaggatc acagagctag taagtggtgg agctgggctt 34860acaccctggc tactggtcac agggctgtgc tgtttctcag ctcttgtgtt tggcctcacc 34920tctccagtca tacttgtgaa agtcctgggt gtctagacag gtgatgggtg agtgacataa 34980ggtacctctc tttgtcttca tgggagaaat aactggattt ccccaagaat gaattaattc 35040ttccacaata caagagtctt agaggtttaa caaggatact tctttcaagg tgcccaccaa 35100ttcctacctt gcattggagg gtgcactgtg tcaaatttgt atttttatct taaataccaa 35160atactcttag agtccatcca tgggcctgtg gagttgaggg taaatgtaga ggcttatttg 35220gcctaataat gaaagtatgg atagttattg ccatggagga ggagggtgaa tgttttgtag 35280agtccattcc aaccttgaaa tcctgattct ctgataaact tccacctctc ctctgttgct 35340taatctttga tcttgagcct ggaaggagag gaggcaactc agtcaatgaa ggagttttat 35400ttagtaattg cacattggcc tcttcctgcc ggatcccata ttgacactgg agtaaggcta 35460gaggctggga gacaaggccc catgggagct ttgtgaaatg gggaggggca agggtgtgtc 35520cctggaccgt ctgtttgtgg ggcagctgtc ctaggtgttg agacacacac cggtctgttc 35580taagatgttc ctactggatc ctgtcagttc gccctccagc attcctggat ttattgtgca 35640ccatttatgg ctccacagtc cactagatga aattgtaaag actcaatatg gtggctctcc 35700agggactttc ccttttcttc tcccttagca tcagagatga cccgtcagcg ttgcaagcag 35760ttctgtggta gcacatcaag tattctgtca cagcaggaaa ggctggataa acatcaaggg 35820actgccaaga ccagacttct cattcagtct gagtaggagg aaagaggaca ggttgttgga 35880gagttggttt aaagatgaat tatgggctgg gtgcggtggc tcacgcctgt aatctcagca 35940ctttgggagg ccgaggcagg cagatcacga ggtcaggaga gttcgagacc agcctgacca 36000acatggcgaa accccatctc tactaaaaaa tacaaaaatt agctgggcgt ggtggcacac 36060gcctgtaatc ccagctactc aggaggctga ggcaggagaa tcgcttgaac ccgggaggcg 36120gaggttgcag tgagccctga tcacgccatt gcactctagc ctgggcaaca agagtgaaac 36180tctgtctcaa acaaacaaaa aaaagagtta tgactggtct ttctcatttc atctgctgat 36240gggtagagga gggaaagggt cagaaatatt tcttttaata ccctctcagt atgaatgaat 36300gattttgacc tagtttaggt tttggtctgg tggatgtgag attggaatat aatttgtttg 36360gcagggtcat ccccaaggat gtctgatgca tctgcgttct tgttcccatg gctagaatgg 36420aatcaaggga gaagcttcct cattcctatt tcagagggag cagggagagt agtggtgcat 36480atccccacag ccagaaatag attggtcctc aagtaaattg gtttgataag ttgattatga 36540atcttcctga aaactgctgt ggccttagga actctggagg gtcctactag tggaccctca 36600tcattcatct gatgagcact tactatgttc taggcactga ctgtgagaaa tacaaatgag 36660taaaatataa tcatagcccc caggatagtc tggtgggtga catttacaat acaatgtaag 36720ctaaggttgt aattaatgtg tttaacaaag tactgtggca gcacagagaa gagagtgact 36780acgtttggag tccacaggac ttcaccggaa agatgaggca tctgacctgg actttgagag 36840gatgaaccag aactctgtag gtccagtaga tggaaggttt tcaaagaatg caggcagaca 36900gagccttggg aacagtcaag gttgaggggg cactcttgtg ggtccacaac ccgagcttct 36960cgcccctctc atttcgtaat ggctgccaag ctcttccttc actgttgttt ttctttactg 37020ctctgtggat tcatcctgat gagtcacgac aacctctgct tgcagtgatg ccacgtctcc 37080cagttaggaa acgaccctgc tcttcactgc ctggttcctt ggtgtggctg cctccagcct 37140tcagtctccc cttctcagag ctgtgacaag aggttcttac agccttaaaa ataaaaagca 37200gcttcatatg ttttgccttt gtgttattta ttgcatcatt tgttgagcaa gtttcccagg 37260actggagccg gaggtcattt gagagatgtc tcctgggatt ccactgaaac tcttttccac 37320tgatcccaat tggtgaccag gaacaggagt tgcttttggt cctttacatc tctccatgtt 37380ttccagcttc ctaagatacc ctgtcccctc ctgcattttg gtcagcactt atctttcctt 37440ctgctttgtg cttctagtgg ttctgggtca ctttctgtca gctcccaaat tccagaggtg 37500gacctgggtt aggccattgg ctgtatgtct tttagtgtgt attgcttgag aatgctcata 37560tttatgtagt atattccgta gtgcctgaaa attctaagga ccacagcgat tttgaatgat 37620tcaaagttag tcacttcagt atgaaacagt gtgaatttaa aggcaaaccc aggattcttt 37680gaaagcaaaa actttcttta gagcagcggc gtgcttggtg aggcaaatag attgcatttt 37740gtggtgccag aaatagacag ttcccttttt atacgctaca tctttgtcat gtagtcagag 37800acatgcagat cctttgaagt gaattctggc accacaattt tgtagagaca gtcagtgtag 37860tacagcatga gaagggcata cgatgtgtca tttgaataac ttctgttgaa gagcaggcgt 37920cagcccatgg cagagattgc tgaggggatg gtgcagacga gaggcaggta gtattggggc 37980attgtgaaaa catgcgtgaa aggccttttg gaatcctgct ttttggcagt gttgtgcaag 38040tccctcagaa attttgtcac ttcccttgga aacatgtaca acagggatac gtcacttagg 38100cagagactac tcaagggctg aaaaatgcta cactcatgaa tagtttcgct gagctggaga 38160ttggtcacat ctgatgtctg gatggtggcc attgttgtta aaaatagctt agaagttcaa 38220aacgggggta ggagccttgt gttctttttt cttccctgga aagggaagtg tttttgagct 38280gtggaacttc gagtaaaacc taacttcttt gtaccttgtt ttgctcatct gtaaatgggg 38340ataacagtgg tacccacctt atgggatgtt caggattcaa tgaatataaa acatttggca 38400tgatgcctgg cacgtatagc taccactggt gtagtgttta attatattta ttattttttc 38460tcattgttac tgttcttttc tatttgagat ttctcggagg ttctgtactt gttttaaaag 38520tataattctt tccatggctt tacttcccgt tagcagtggc ttaattctaa ctgggagaaa 38580aaacctttga tttgtggtaa ttttcttaat tcccttgtct tacctttggg atggtggagt 38640tgggagggca gtgcagagtc agatgtcagt ggggaacaga gattgtgggc agtcccaggc 38700agaggcaggt gccagctggg actgtctagt gccctctcaa ttatttgatg gtggaatgga 38760tgattattgc agtttgtcaa taaaaaaaaa caaaccatag cgttagtgtt aggagtagct 38820gagtgaaagt atatgggaat tctgtgtact atctttgcag gtcttgagta aatctaaaat 38880tatttcaaaa tgaaaattaa agccccagca acaaagcagg atgtagcacc atgctgacac 38940tagtaaatgc ttaataaacg tttgttggat gcaagagtga gtgagtgagt taggtttgaa

39000cccaacctcg acacttatta gctagattac ctttggttaa ttactgcttt tatgaatctc 39060agatttctta tttatttatt taattatttt tttgagacag agtctcgctc tgtcgccagg 39120ctgtagtaca gtggcgcgat ctcggctcac tgcaacatcc gactccctgg ttcaagcgat 39180tctcctgcct cagcctccca agtagctggg attacaggca tgtgccacca cacccagcta 39240atttttgtaa ttttagtaga gacagggttt cgccatgttg gccaggctgg tctcaatctc 39300ctgaactcgt gatcccccca cctcggcccc ccaacgttct gggattacag gcgtgagcaa 39360ccacacctgg cccagatttc ttatttataa agtgccatga tgtctacctc acagtgttgg 39420tatgagcgtt aaatgagatg taaagaacct gatcagagga tccagttata tggtaagtag 39480tctaaagtgt aggtattatt attgttaaag atattgtggg cactttgttg attgaatatc 39540cccccccctc cttttttaga gccaaaatcc atttaaaaaa tacatttagg tttcttgcag 39600ttttttgctg ttatgaacaa cacttccatt aataggatta atagctgtat agctagatct 39660ctgtgtgtgt acattatgta ttcttaggat acatttctga gagtcacatg ggttcctatt 39720ttttggctct ttttattccc ttaccagagt gcctcccgat agtttgtaat tttgtaacaa 39780tttaccatta aagaacagag ttttgatagg cagagatggg agagtaggag agagggagta 39840gcctgtacac aaaaggattg cctcctttac cccaaaggtt gaggcctctg aatgctggtc 39900tgagctccta gggatgatgc ccctggagcg tagtaattgc ctaggataca accactcagc 39960cttgtgccac catggtagga cacccaccat gctgggtgtc ctactgccat ggttggggag 40020ggctgaatgt tttcaccctg ttgctggggg aggtggggac ttggatgagt gacacccggc 40080gtggacagct accacctgcc catggtagat gaaaccttac tttcgatggg aatggccctc 40140ccttcttatg ggagttgtag tctgcatgga gtgcggttga acaaggatga gcaggtaatc 40200caggtgtact tagaatttgc ttcctctgaa tattagaacg tgaagaggac tttgagggaa 40260tccagcatgg tggttttgac tctttgaaaa tcaaggaacc ctatttcata tcaagtccga 40320tgtggaatct cagtgtacta aagagtttat tttttttatt atacattaag ttctgggata 40380catgtgcaga acgtgcaggt ttgttacata ggtatacacg tgccatggtg gtttgctgca 40440cccatcaacc tgtcatctac attaggtatt tctcctaatg ccatcccacc cctagtcccc 40500caccccctga ctggccctgg tgtgtgatgt tcccctccct gcatccatgt gttctcattg 40560ttcaactccc acttatgagt gagaacatgt ggtgtttggt ttttggttcc tgtgttagtt 40620tgctgagaat gatgatttcc agcttcatcc atgtccctgc aaaagacatg aactcatcct 40680tttttatggc tgcatagtat tccatggtgt atatgtgcca cattttctat atccagtcta 40740tcattgatgg gcatttgggt tggatccaag tatttgctat ggtgaacagt gctgcaataa 40800acatatatgt gcatgtgtct ttatagtaga atgatttata atcatttggg tatataccca 40860gtaatgggat tgctgggtca aatggtattt ctagttctag atccttgagg aattgccaca 40920ctgtcttcca caatggttga actaatttat actcccacca acagcataaa gtgttcctat 40980ttctcacatc ctttccagca tctgttgttt cctgactttt taatgatcgc cattctgact 41040ggcatgagat ggtatctcat cgtggttttg atttgcgttt ctctaatgaa cagtgatgat 41100gagctttttt cccctatgtt tgttggccac ataaatgtct tcttttgaga aatgtctgtt 41160catttccttt gcccgctgtt tgatggggtt gttttttcct tataaatttg tttaagtttt 41220ttgtagattc tggatattag ccctttgtca gatggataga ttgcaaaatt tttctcccat 41280tctgtagatt gcctcttcac tctgatgata gtttcttttg ccgtgcagaa gctctttagt 41340ttaattagat cccatttgtc aattttggct tttgttgcca ttgcttttgg tgttataatc 41400atgaagtctt tgcccatgcc tgtgtcctga ttatggtttt aggtcttaac gtttaagtct 41460ttaatccgtc ttgagttaat ttttgtataa ggtgtaagga aggtgtccag tttcagtttt 41520ctgcatatgg ctagccagtt ttcccaacac catttattaa atagggaatc ctttccccat 41580tgcttgttta ggtcagattc gtcaaagatc agatggttgt agatgtgtgg tgttatttct 41640gaggcctttg ttctgttcca cttgtctata tgtctgtttt ggtaatagta ccatgccgtt 41700ttggttactg tagccttgta gtatagtttg aagtcaggta gtgtgatgcc tccagctttg 41760ttctttttgc aagagattaa tcttataagt tcagacttgt aggtatcata acttataaga 41820atcatccatt tacttaccct aaataaatgg atttacaaga gattaatttt atatgttcag 41880acttgtaggt atcataactt acaagaatca tccatttact tatggtaaag tcaagagaac 41940aatgaagctg ctgtagtgag cactgaattt taacttgggt tctgagtggc agtcccagtc 42000aaatgccagt ttcattaccc aggttccatc tggatttaat tttgtttgca gtatagaaaa 42060gtctgatttg catggataag taattgcaga taagaatagt ttgctaatac cttgcaattt 42120caggatactc tttaattaaa ttgatccaga agcctgaaag atgaataggg ggaactttgg 42180tctccaagga gaatcacact gtttaacaaa tactttcatt ctttattaca aactgcaaga 42240cagatgataa tgtatggtca ctctttttat tacaatgcag cctgttatga attcatttgc 42300ttttgcataa ctgactattc ccctgtgata agagcataag ccagcagatg tgcctgagat 42360ttacctggca tttaactgaa catactgcag gtgtgctata gcagtatact tgcttgaaca 42420gttttaaggc accagacaag tacaggcctg aatttttaaa aagataattc cagtttcctt 42480cagaatcagt gacatattta caagatacta atataagctt agaattggca agagcagctt 42540tattctgagg tctacaggaa gataatgtga acacatttgt catcatcagt gtgctaaaat 42600ttccaataaa atttgaatct gtgggagttt attataatct ctaaaatcat taatatatta 42660ccttaaaaat aaaattgaat actttttttg cagagttttt tttttttgtt tttttttttt 42720ttttttgcag agttttatag cactcagaac cttttggttg ctcagaacat agcttgaaaa 42780tcctgatctt tcacatattg cagcctcagt ccttttataa atgatgagat tcaggtcttg 42840ggggtgaagt gactttccaa atgtaattcc agaagttact gggaaagcca agaggaagag 42900ttcttgggtc tctttatgct cctctaagct atttttctct gctgagcagt taggactcct 42960ggagggggca ggaagctgtg tgctcaagtg acatcctttc tttagttttg tgtgtgcata 43020tttgtgtagg cacatgaatg cactcttgta tacctactag gtgcagtgag agctggcttc 43080agggagaaag ggaaatgcgt gattttgggg tccccagcct gagcctactt tttctcgcag 43140tattctttgt tctggaatct ttctcatcac cttttattgc atggaaactt aatctattca 43200ggtcccaact ttcaggcttc tctgctctga caagtactag aggccaatat gatagactag 43260tctgagttaa aaggtggcag tgaaggaacc agctacccct ccctgttttt gtattatcat 43320aagcacctca tggcatagaa tgctttcacc ccaagcggct gtttcagggg cactggcagg 43380tttggagggg cattgtgttt tgaatagtca gtgccttttg tgccattaaa ctcccatggt 43440agagagaccc agccttaaga aataagactg accctccata gggctgctgc tagtctatat 43500attgtctttg tgaaaattag aaaacagcat cttgtctgag tggggtagcc ctgcaccaga 43560gagtgtggcc tggctagtaa aaggcagatt ggatttcagc catcactttc ttacctcagt 43620tgggcattct tggcagtgcc caacctgccc aaccatatgc tgtagtcctg attctacctg 43680ctatcttcca gccaaataca ggggctttgt attcttttgc attatacaga tgtgttcatt 43740gtggctgctt aatagacgtt tgagttgatc gatactcatc gttgaccaaa tagagagaat 43800ggcactttgc aggatgttta tttcctgctg tccccatagc agcagcaacc atcagcaacc 43860tgttacctta aggattctat agttcattca tttattaatt caacagctac ttcttaaata 43920cctataatgt aaaaggagac agggtaccaa gctacaaaga gcaccatctt tggagtcaaa 43980tctgggtttg aagtttgtct tttctgttga ttgtctgtgt aatatttgac aaattattaa 44040actttctgag cctcatttat tcgttcattt gcccacttat tcaacagata tttattgagc 44100atttcccttg gctggatgaa gatggaaaaa aaaggaagac agacgcagtt ctttccctca 44160tctctagtga ggatgtggac acaaaacaaa tacatggatc aacacataac aattctaggc 44220tgtcataagt gccctgagga aaagaaacaa ggatgtgcta aaatgaatag gacctgggga 44280gtggggggag gggacacggg agaccgtgcc agagagacag agctctttct taatagggtc 44340gtcagggtac gcccatcaga ggtgagcaca taagcagacc caaagaatgg tgaggacctg 44400gcctgcagag agcagtcagg gctgaagagt cagcttggac aaaggtggga agtagttggt 44460atatttgagg acataaaaat atggacttgg ggcataatgg aagacaaggt tggaaacagt 44520gatgatgata acagtagcaa gcacttgttt agttcctgct atgtccagac actgtgctga 44580gtgccttcac atacattaac tcttctaatg ctgaccaaaa tactacggag catgtgttac 44640gatcattgtt ttacagatga agaaattgag gcacagatgg gataaataac ttacccagga 44700tttcccagct ggcacgtggt agagctggga ttcaaacaca cgtgttctgg ttccagactg 44760tgcttatatc tgctatgctg tagtgccagt gaaggctggg tcatgccaga cctcagtttc 44820gtcatcagta aaatggaact aatatgtgga ttaaacaaaa tgtgtataga atggcagcca 44880catcaagtca taagcattca tcaggtggac tgtatatcta gtggtggtgg tggttgtggt 44940cagcattgta ggaaaataca ggggtgcatt aggaagtaac cctctaggga agggccgtgt 45000atactgataa tcgttaatgt aaggaggaca ggggtaaggg ccctgaggaa agtgtgtgca 45060tgaacagtgc tgcgatggct ctgaagtggg tcagtttgtt ccacctgggc agtgtggagc 45120cacttggggg tggggggagg ggatcctgct gttgagtctg gaaaaatggg caggagtcac 45180atatactgga gcaggtagga ggagcatttc ctctgcacca tcaggtgagc aaagatctag 45240tgtgtactca gagttggaaa gtggggtctg gagacaatag cactggccgt aggagagagg 45300caggaactgg agtgaagata ggttagagcc agcactcact ggggcttgat gccattgcga 45360agctttcagt ttatgcatca gggaatgtgt ggtcctgggg tccacagctt ggtttaaaga 45420tctaatttgg gtatcttctc agctttctgt gactctggct gagcagcaga gaggaatttt 45480gttttggctt ttatttgata tgctatctgt catctaccta aaggagcctg cccacctcct 45540gggttcatac agaggagagg taccactata gtgggaagct ttatgacccc actcctccag 45600acaggtggtt ttataggtga ttgcaaataa ctggcacagg cttggagcta gacagatctg 45660ggctgtataa tctgggcttt aacagcattt gaccttgggt cttgtgtttg ggcctcattt 45720agttccctgt aaagtaggga tttataccat gtctcattgt tatataaagg tcaaataagt 45780gcatgacact atgtgcctga agaacatggt aagtgctcag atgatgttag tcggaattac 45840tagattgcat ggtgtggaag gcccagttac ccacaggaag tcagtttgaa ccgactaatt 45900gtcttctccc atatttttga ggtcaggaag cctaatcagt tggcaggact cattggagcc 45960acattgagat ggattttaaa gtcattccca ggctctgtgg gacatcaggc catgatgtat 46020acacagtttt cttcttcttg ttttattttt ccttaaggct ttattttctt aaagcagttt 46080taggtttaga gcaaaaattt ttttttttga gacagagttt ccctcttgtc tcccaggctg 46140gtgtgcaatg gtgcaatctt ggctcacttc ctgggttcaa gcgattcctc tgcctcagac 46200tcctaagtag ctggcattac aggtgtgcgc caccacaccc tgctaacttt ttgtattttt 46260tttttttttt agtagagatg gtgtttcact gtgttagtca ggctggtctt gaactcttga 46320cctcaggtga tccgcccgcc tcagcctccc aaagtgctgg gattacaggc atgagccact 46380gcgcccagcc tagagcaaaa ttaagaggaa ggtacagatc tcacacttgc ataacctccc 46440tcataaccaa catttcccac cagaatggta catttgttgc acttgatgaa cctacactga 46500catcattatc acccaaagtc catagtttag attagggtcc actcttggag ttgtgcattc 46560tatgggtttg gacaaatgta tgatgacatg tacccatcat tgtatcacac agagtatttt 46620cactgcccta aaaatcctct gtgctttgcc tgttcagccc ctgctgacca tgtgtatttg 46680ctgtcctggt tttagatcat cattatgggg ttggaaaaat agcatcctat aaaggtgttt 46740gtggctttaa gtgaatgtca gcagttctac agtcctgtcc agtagatgcc atctttcaat 46800ttgctgaaga tactgattct gtttttctgt tacttcagaa caaacagagg aattttagaa 46860gaactaccac ccacttcctc agacttactg agcacctgct taggagccac acatagttct 46920aaggttgatg catgacatac aaagacaaga ccctacttgg cctcatagca gagcacagct 46980ggggcagtgg acccttgttg tttgtctctt tgatgccggg ctgggtacct ttgacattta 47040ggaggtcatg gctaggaata ctaggaatcc tataatgtgc acagcaatag tcctgtggat 47100agaagaattt ttctatagcc tgcatgactt tcaaatgtct ccccagacat tcttgcaggg 47160aaaaagcctg ttcataattt tctgaaccta gaacctgtaa ttccatttta tgtaacggac 47220tttttgcatt gttttgatat acccttaatt ttctaggaat gccactactt tgtaaattga 47280tacgatatac tatataagat actacactat tttgtttgta actttgccaa aagctgttta 47340ccatttttat aaatcacttg ccaatgttgg tgtgcatgta tttgtgtcat caagaataat 47400atgcaagtat ctgactgcat ttatagttat tgcattcaga gttgttctgt tgttgtatta 47460gactacttca ttatgtcttc tgatgtactc gtgacagagc aattactatt gaaatatata 47520ttcttacaga tatctttaaa ttctttattt atagttagga cattatatta tgttgaaatt 47580gtatatagtt tatattattt ttgattttca tttcagggta gtaaagggag agcattatga 47640cataaatgtt ttaaaaagca gcaggagtcg gggtgggagg cgttgggaac cgttggtctg 47700atgcactgga accatatcag taagacctgg caaagtgcag agaaatctgt gggggaaaga 47760gtttaagctt cattttgttt taagtcatgg catgtgtggc cttgattcta aactctgtgt 47820ttgaataaag ttgtttttgg ctggtggttt cgaagtttta gaaaatggga gtgtatgagt 47880agatgtgaag tggttacagt ggtttagtca cagcaccctg ggcctgagaa tcttagccag 47940agggactcta atttgtgaca tagtcaccac agcaaccaat ggaaatgtcc ccatgtgatc 48000tgaaccaaag tggttttgga gtgttaaaaa atgtgtgttt aataagctaa aattatctgt 48060taactgttcc aagggtgatt tttgtatttt caagcatgca caattctaat taaatggcat 48120tgtgtaatca cttgtggtct cagtgtagtt tataatgagt tagaataatg aaggggtagt 48180gagactggaa gttagagacg cagagagcct ttctgcttaa ggtatcctta aacagatagg 48240tgttaggacc agcaaatagt gatcccagaa acacaataca atatttaatg aagtgctaat 48300tatgttgcgt gtcagtcatt gtaggctgca attgatggag ctaggtggtg gaggaggagg 48360aggttggatt gggatgggcc ttgaagggta gtaagtagaa tgttaatgga aagaacctgc 48420aattgtttcc taccccaact ttccaagtta ttattatcca cagagtcaca ttggcttgta 48480ttccaaattt actttatagt agctaataag tatctttttt atttagtacc taacgtatga 48540tttccactgt ggttggtcct tgacaacagt taggtgagag cgaattgata ctagagatgc 48600agaaatgtaa ggcttagaag ctcaagtgtc caggaccaca cagagctcat aagtggcaga 48660gccaggattt aaactcaggt ttgactgatg tcaaagccac tccttatggt ctttttgata 48720tttttgctct agagatggtg ttcatgatta gcttgtttac ttaccaacca ttttctattc 48780agattataaa gcagatctca tttggccgag acttggagat ttaagttttt gatatgtaat 48840ctatgattga atttaaatga ggtatggtta gaaagttcca gcccagttag taatttagca 48900ccttaaagca ttcaacaagc atggttaacc aaaaacctaa atcatactaa atgtttgaag 48960tggtgaacag gagggaatat ttttatattg ttactagtca gctttaaaaa aaaatgtgtt 49020tataaactga gaagtctagg tacatgacat ttatactcct gatgtttgac tggctttgga 49080aattcccacg ttgtgacttc ttgtaagctt ggctgaatga actgacaggg gattccagcc 49140cttactgtat aattaaaggt aaagatacag aatgcatctc tctacctcca actattgtgt 49200agttagttgt agctaccaat gaaattatca ggtcaatgca aaaaaaccct tgtttttatt 49260tatacagggt acagggatgg tctgattagt tgttctcaag taactaactg gggggtgggg 49320ggcatttagt agtgttgttg ttgtggtttt ttttttccat aagaacaatc aaatgaggaa 49380actaatagca ctgtgggctg cttagggaat ttttgtcact gaaagaactg ctgcaagccc 49440tgtgtctcag gaagggtgat ggaatgtcta aatgtccatc tgtcgggaga agattgaagt 49500ccctatgccg atctactctg cttgtgcaac tttgtgattt gcagccagtt acttaatctc 49560tctttactgt tgttgactga agtcatgcta tagctggtat ttcatattac aaggacagag 49620ttcaagaatt atcttcttgg ttggaaatgg aaaggaggta tatctggagt caagtccaaa 49680tgggtaagcc atctcactct agaaactcac tgtacaaagg gactaagaag ggaatagaga 49740agctgccttg tttataaaag gttgatccac tcccaatagt ataatcacaa caatttctaa 49800gaggttttat ttcaaccact tattttctta tccctaggtt acacatcagt ttggtgagaa 49860gagctcagtt tttggtttta gatgagctga gtgcttgtct cagttcagcc acttgctagc 49920tgcatagcct tatgcaaggc acttaaattc tctgaatctc tgtttcttta tctgtaaaat 49980gatttccagt gacctactat atactctagt aggtcactgg aaatcagtta agttaataga 50040tgtgaaagtg ctttgtacac ttcaaagggc tgtctaaatg tctgtatgag cctgaaggat 50100agttgttatg ctttcagtta tcagtagtct aggtggctgt gcagaaaggg agaggcgagg 50160gagtcatatt tttgacaact aacttggggt cctatgatcg aaagcccaga aatcctcact 50220tagatttttt ccctaatgca gcagtcttgt gctggatttt ggagtgtggt agaaacatat 50280gctacactta ttaaaggggt ttggcactct gtaatgtggg attactggca tagaagatga 50340aatgataaag gaacatctca tcatattcag atgtgtgagt catgcacgct tatgagttac 50400tctgaaaaat ggaattataa tagaaatggg catgagttca acttacatta ttttccttgg 50460ctttagcagt tttcaggtta aaagtcactg gatacattta actgtcttaa agcatagcat 50520ttataaaaag cttttagaac ttagactgta caaaagcacc tgaattggaa actgtgtctc 50580ttattttttc tatcagtagg atattaggga cagttttgca ctggacctgt tcctgtgtac 50640tgccttgata cttaactcag tcagtgaatc agtaagcagg aatatatgga ctcctataac 50700cctattggcc ttcagggagc ttcatggtca tttattctgc ctgcctgttt tacagtgggg 50760aaaactgagg gccagaaggg ttccttgaat tatccaaggc ccaaggttag gttctggcag 50820aggcagggtt agaactcatt cagtccacac catgctgtct ccagtgtata tgtgctggat 50880gagaaatttt ccactgccag cattaattta atttaattta attttagttt ggtctagtgt 50940agtctagtct tggattagtt taagacagag tcttgctgtg tcgcccaggc aggagtgcag 51000tggcatgatc tcgactcttt ccaatctctg cttcctaggc ttaagcaatt ctcgtgtagt 51060tctcagcctc ccaagtagct gggactacag gtatgtgcca ccacacccag ctaattttta 51120tgttttatgt agagatgagg tctcgccatg ttgcccaggc tggtcttgaa ttcctgggct 51180caagtgatcc acctgccttg gcctcccaaa gtgctaggat gacacatgtg ccaccacact 51240tgtcctgttt attccattta aattacagtt cattttgtgt aagccacttt tccctgtttc 51300cgtcaatttc agatttggaa atacttttca aggattatcc ttaatactac atctcctctt 51360tatgcttaaa aattttgttt gattctttaa ccagaaatga tcatagtgat ttttaacttt 51420caatagggag ctactttttc attaattact tgggtcatat ttgtcacttg attcttagca 51480cttttttctt ttgatgtcgt ttattattta ttgagaaaca tttgagttct tactctgtgc 51540caggccctgt gcttagcagg tgctggaggt gagaaggcac taagtgatgg aaggacctca 51600tccaagaacc cgactctgtc ctgagaggat ctagggtgtc cgtcaggccc caccccattt 51660gacttaggac cattattgtt tttatagtag ctacttgaaa gactcattag gaaaagtcat 51720gcttttgttc atttctgttt tcaacctagc taaggagaca tatattacaa gtaaataatg 51780gcacaaattg gcaaatgatg aaagtccagg ggattattgc ctaggtagaa ttttagaaag 51840atgatgtgga gaaataggaa cacttttaca ctgttggtga gactaaacta gttcaaccat 51900tgtggaagac agtgtggcga ttcctcaggg atctagaact agaaatatca tttgacccag 51960ccatcccatt actgggtata tacccaaagg aatataaatc atgctgctat aaagacacat 52020gcacacgtat gtttatagcg gcactattca caatagcaaa gacttggaac caacccaaat 52080gtccatcaat gatagactgg attaagaaac tgtggcacat atacaccatg gaatactatg 52140caaccataaa aaacgatgag ttcatgtcct ttgtagggac atggatgaag ctggaaaccg 52200tcactctcag caaactgtcg caaggacaaa aaaccaaaca ccgcatgttc tgactcatag 52260gtgggaattg aacaatgaga acacttggac acaggaagag caacatcaca caccagggcc 52320tgttgtgggg tgggggaagt ggggagggat agcgttagga gatatactta atgtaaatga 52380caagttaaca ggtgcagcac accaacatgg cacatatata cctatgtaac aaacctgcac 52440gttgtgcaca tgtaccctag aacttaaagt ataataataa aaaaaaaggt aaaaggagcc 52500aggtgaaatt aatatcctat ttcaacatgt aatcaatatg agaattgttt atgagatact 52560tataaatttt tcttcttcga aaaaaaagtt gctgccattc aagatggtct ttaaagaagc 52620gtagtatttg attactggag aggataaggt aattgatttt ttttcaagtt tcagttattt 52680gttaatgtaa tctccaacac attatatcaa catgatttca tgtatctaaa ggagaaatat 52740ttcctagtta agtggaaaat agtgcagcta gcttctggaa gatcttcatt ctaagcagct 52800ttatagtgaa acatttcatt tagaaatctg gaccatcttt cttcagttta ctgtaatcca 52860cattcactga gtagaacttg tattgctcat tggaacccag tttattccag ggccctgggt 52920cattctttct ggcccaacta acatctggat tgaaatgcca gatgcaagac atacagtgct 52980gctctggtac ctctagctcc attaaataca aagaggggga tcaaactcag ttccttggcc 53040tgaccaagga cctggtggag catgttttca gcaagggcat ctgatttaaa aggagagaac 53100tagcttagct gccaggccct tgactaagta gtatctcaga ataaagtaat tgaaaattaa 53160tgagtatcta cttagggtct ctaaatatat ttaattttct atggagggaa ctttttaaat 53220tgaaaaatgt atcaacatag agaagactat gtaaacagta tgtgtatagt tagagaaaaa 53280tacctatgta tccaccattc aggttaagaa agagaacatt actggtatct tagaaatcac 53340ctggtagtcc cctccactgc acttccctca gaggtaacag tcacccccac tttggtatta 53400atcatgccct ttctaccagt gtatatgtcc ccagagcaag cataaaccta ggtgtataag 53460gaaagggcag tgatgccatc tctagatgaa ggctcccagg agaagagctt catggtctct 53520ggttgaattc attacccctg tgtctgaaca gaaactctgg gtcaagtctg gatccagagt 53580tgagaggttg cagggaccct tttgggaaag tcagtggaaa agatcatgaa tgagttgtgg 53640gaaacagggc ttctcatagt tggaggtacc tagaagactg cagtgggccc agctgttggg 53700agcctgggag gagtggagtc aagaggaatg tgctgctcca ccctggctta tgtccagctc 53760tcaggaatag gccaaatgga atacttctgc ggggtgaaat agtcttctgc tgattcaggc 53820agcaggacac agcaggggaa caggaatttc atcagtgcat gattaagaaa aaccaaattc 53880cattaggaat ttggtccagg ctcacccagg cattctaccc tcaatgcagt ctacggggat 53940cttggcagtg actgccctca acataagtat ccctcaagtt gccctgctca catggggatt 54000ggtcatcctc tgaggctggc cacagctttt gtgttgagac cgctctgttc tgtgctcctg

54060ggagttccct tcacttcctc tttgtttaat ctttatttcc tgtgttggag cctgtctcct 54120gttattttca gaaggatgca tagcagtttg ttttttgaga tctttgatgt ctaactgtat 54180cttgattctt ccttcatact tcgttgataa tttggctggt tatagacttc tgggttggaa 54240gttgtttccc ttcagaattt tgcaggcatt gggtgcctgt ctctttcctt ggtgcagctg 54300ttaaaaagcc tgagaatatt ctcaattttt gatcttttga atgtagcctg ttttattctc 54360ttttggaagc tttatagacc cttgtttcca atgttatgaa atttcccagg aatgccccaa 54420acaggtcttt ttctccattg ttttgatggg cctttccaac ctggcaactg gtagcctttg 54480gttctgggaa atctttctca aatggttttg ctgatgattt tctcccctcc actttctttg 54540tcttttcttt aggaattcag acatgtgact gtctggattg ccccctttaa ttttcttatc 54600tcttttctcc tattttcaaa ctgttctttt ctaacctatt tcctaaactt tttttttttt 54660ttttgagaaa gggtctcact ctgtcaccca ggctggatgg agttcagcgg cagaatctcg 54720gctcactgca acctctgcct cccggttcaa gcgattctcc cacctcagcc tcctcagtag 54780ctgggactac agatgcatgc caccacacct ggctaatttt tgtattttta gcagagacag 54840ggtttcacta tgttggtcag ggtgatcttg aactccagac ctcaagagat ccccctgcct 54900cagcctccca aaatgctggg attatagtca tgagccactg cgcctggcct tttcctaaac 54960attatcttcc aaccttttta gcttttgaaa attaagatat tatttaccta cagcaaagct 55020tatcaatgct aagtgttcct ttggctgttt tgacaatcat ataggcttgt gcagttacca 55080ccctaaacaa aatatagaac atttctatca acctagaagt tccgtagggc cctttcccag 55140ctgtgttttc atttctgtta ttatcttttt aatattcgag agctcctttt ttctctgaaa 55200tgttacttta aaaaagaaac attttattct tgattcacaa ataaaaggta ttcttttatc 55260tttctgaaga cattaatttt taaagttttc tctctgtgta atgttttctc tgagttgctt 55320ttttctatct ccatgtctgc attagaggct ttcctcagac atatgtttac cttggctgtt 55380tgtttatgat taaacttgga ggaaggctga gcatgtgcct cgggcttgtg aactttgaac 55440gtcactaaga gtgagccatt cattggggaa ctcccagcct ctgtgtcttt aggtcagtcc 55500tggtgagatg gtcacattcc tcagaagaca gtattccagt ctctcacctg gagggctagg 55560gactggctgc cagcatttct ggagctgcag ggaagagggt gaaggctgta gcatcctggc 55620ccccagcact cagcatgtgt gcagatgccg tctttctgcg tgcccagagg ttcccatgct 55680tcacctgaca tctctagtta caggaccctt tgtcttatcc tttccagaaa ctaaacctct 55740agatatgtgt ttccttataa taaaatagtc actagccaca tggtagccac ttaaatttaa 55800attaacattt aataaaatta agaaatcggt ttctcagtta cagtagccat cttttaaatg 55860cctggtagcc acatgtgact ggctgccgta ctggacacag cacagataca aaacgtttcc 55920attattgtgg accattttac tggacagtgc tggtctagac ttttgctggg gcagaggagt 55980ggccaacggg attctttttc tcaaacacct ttctctggcc ctctttcttc accccagtta 56040ctggtgcttc cttccagttc ctgtgacttt ggagacttct gtggtatacg ttaatttggt 56100tatcagcttt tgccattgtc agcttgggat tcagtatttg tggattatcg aagtcaattt 56160tttttttaca tatccaacta ctttccagtt tccaaagttg tagttttctc ctcttctttt 56220ccccttacat atttgtgaat ttggtcttaa acagaaaagc catgctgtat ttattatact 56280actttatata ttttaaaaat atgtactata ttttagtgga gtttcagaag ggagtgaaat 56340tgggtatttc tgttcaatct gccattttag ctgggaatcc tgcctcattt accttcacaa 56400tcctataagg tatatatgtg gttattctca ttttatagtg aagagaggca ggtaaaataa 56460ttgactcaag gtcacatagc tagtaagtgg gatttgaagt tggatcagac ttaaaaaatc 56520agagagcttt ttttattaaa tagtgttgtg ccttatcttg tattgaggaa agacccaccc 56580atcacacgtt ccccaagttg caatactata gttatagttg tgttttaaat accatgtgtt 56640tggctgggca cagtggctca tgcctgtaat cctagcactt tgggaggcag agatgggtgg 56700atcacttgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac 56760taaaaataca aaaattagcc gggcatggtg gtgcacacct gtaatcccag ctactcagga 56820gactgaggca ggagaatcac ttgaacccca gaggcagagg ttgcagtgag ctgagatcac 56880gccactgcgc tccagcctgg gtgacagatg agactctgtc tcaaaaaaac aaaacaaaac 56940catgtatttg cccagatact tcccagttat ccttacaacc acttaataaa agaggtcagc 57000cttggatagt tctgtctcag aaaggttctt ttctcctcag ctgtttattt cgttgttttg 57060ggactttaca acctctaaac tttgtgttag ctttttcttt agcagttctc aaagtgttta 57120gagtcagaag cattccattg tttaacttaa accttttatt tgaagcatct atggtcattc 57180tcttatatta aaattgttcc ctcttcattt aacctcactt tccataaggc agcgagtaga 57240tcgtgtttat ttttgaatcc ctagtgcctg gccccttgtc tgaggtaggg gattcatagt 57300gtttggttca acatcatctt ttatttggac cattgcagtt gcttccaaac tgctggtctc 57360tgccttctgt cagctgctct caaaatgacc tgacattggt ctttctcaaa atcaacaatc 57420actggcctcc tctaacctgc attgtagagt cttggctact cagcatggtc tagagggttg 57480accacgcctg cctctgtcca ctgctgtagc cccatgtctg gccactcacc ccccaacgca 57540ccctccagtg caccaatgtg cactttgtga aaggaccact acatgctctc aaacttgtgc 57600tcttatttct gccagaaatg tgctatctcc agtcccacct atttctgtta tttaatatct 57660atttttctgc aaatcccagc cccaggacat tctctgtgaa acctcgtctg atccaccctt 57720atatggagtt agaagattat ttttgctccc acacacttcc tttcaattcc tccctccctc 57780cctccctccc tccctccctt ctttccttcc ttccttcctt ccttccttcc ttccttcctt 57840ccttccttct ttccttcctt cctcccttcc tccctccctc cctcccaaat ggaatcttgc 57900catatgtatt attctgcagt ttgatttttc tccttaatac gaagcttatc atgttgtaac 57960tattgaatga ttagtcagtt ctattagtgt ctggttcata ggaattatta tcattgtatg 58020accaatttct agcacagagg ctggcacatt gtaggcacac aaaaattatt tattgagtga 58080aattgagcca tggtgttgag tgagtccatg gcagttcact tgccatttat tgtctttgaa 58140ttctgctgtc agtagggtgg tcatatgttc cagtatatgc ctattcctat tttcccagca 58200tagttatgaa tagttcctga tgttttaata tctcctagtt ggtacagtaa attatatgga 58260caccccagcc tgggcaataa ggcgagaccc tgtctctaca aaaaaataga aaaattagcc 58320aggcgtgatg gtgtgcacgc ctgtagtctc ggctattctg gacgttgagg tgggaggatt 58380cagcattgag cctgggaggc caagattgca gtgagccaag attgtgccac tgcactccag 58440cttgggtgac agagtgagac ctgtctcaaa aaaacttata tataattttt atatgtatat 58500ggccacccta ccaattaaac agatctaagt ggaagctcat tttaccttat ccagtggaac 58560agctagagag taataaatat ttggggtatg aggttgcatt tgaaacattg aatccagttt 58620ctttccagcc agccaatcag caaagcccca aatcacacac tggaaaaaat tacctttgat 58680gcatcttcaa agcctaaatg tttcatgttc cagaaggact gctgattcct tttagaagta 58740cttttacaag aagtggttta cctttcagaa atggaccttt ttttgttgtt ctgccgcttc 58800ccagcagtat gaccttggca aagttctccc ggaatgtaaa atggggatga gagtagtcct 58860gctttacagg gttaatgtgg caattgagat cattcatgta gagtgattag cattgttagt 58920ggcatagtaa gtgcttagca aatatcagct tttattattg gtgttatgat cgtgaccatt 58980actatctttt gacatagact agtttagaag acgttggtta tggtcttgaa aggagtgact 59040aggatctgcc ccacagcttt ctgattgcaa tgtgtatgcc cttaactgcc tgtcaatgca 59100ggatgctact gcactgtaga ggatggaaaa agaaaatcag taagaagaaa tcatgtgtgg 59160gttgcaaagg agagagtaga atgacataac tgtggttgct agtgagtcag gggctagctg 59220tgtctacctt ggaaatcttg ggtgggtcag atttggattg acattagaac agatgggcct 59280cagaatcacc tggagagttc aaaaaattgt ctactctggg ttccagcctc ggagaccctg 59340atggatgtag ggtaaggatt ggaattcata tatttttaaa aagctcccag gtaattctga 59400tacacagctg ggtttgagaa ttactcgatg gagtgaccat ttattaccta ataattctgt 59460aaagcatttc ctgatcattt gctatttaat gtaaggcaga tgatgacata ggggtcagaa 59520aacagaggaa gattattgga gagcctgaat taatggaatt aaattttatg agagttttga 59580atttaagcct gtcatgaatc tgtgttgttg ttgtctagga tccttgccta tatttagatc 59640atttgaaatg aaataacaga aaattgtgaa atcaggaaca aagtcctgtt agaaatgtaa 59700aataatcaaa atatgaacct agctatgctt ggatttaaaa ctgaaaggta gatattttct 59760cctgacattt gaaaatgttt tcaactttta ttgctcttac tggaaaggag aaagaactta 59820gctaggtgca tatcatggat acttgactgg gtccaggtca ttacttagat gatttaatgg 59880aagggcattg ggttaggagt cagtagacct gcgtggagtc tcagctcaga tacttctctt 59940tgcaaaacct gagttagtta cttcagtcat ctttttggca tgtatttaca tatctgtaaa 60000acggagacaa tgttattggc ctctatccgg catgatattg ttgggggtgt aatgaggaca 60060tgtatgtgat aggaatgtaa agctgtgatg aacacagaga gtgaccatat gtctctgttt 60120gcctggggca gccccagttt acacctgttg ttgggtataa ttattgatag cacactcttt 60180aactctcagg tatcccagtt tggctgataa attatatggt caccctgtat tcataacacc 60240catctattgt ttactattaa tctttcgaag taggaaggtt ttctggcctc attcctgtgg 60300ccccaaatcc ctcaccaaat aagtatttct tagatgcttt ctggtagttt tcttcaattt 60360tatgtgaatt tcatctctcc aactacattg gtcagtagat aataattgtt tttttttttc 60420actcctgaat aattttcttg tttatcatgg tattagcatt ttaaacattc taattgccca 60480ttttggttgg tgcatcttaa gaaagtaaat ttgaagtgca ggcagaggac agaggaaccc 60540cagcgggaaa tggctttgtg gaagtacact aaaaatgaag agtacagttt gtttgctgat 60600gttctgactt ggtgttttgg aatctaaatg ccctatgttg attttttttt tttttttttt 60660tgagacagag tcttgctttg tcatccaggc tggagtgcag tggcgcaatc tcgactcagt 60720gcaacctctg cctcccaggt tcaaactatt ctcctgcgtc agtctcctac tgtaatctca 60780gtagctggga ctacaggcgc tcgccaccat gcctggctaa tttttgtatt ttcagtagag 60840acaaggtttc gccatgttgg ccaggctggt cacgaactcc tgacctcaag tgatcagccc 60900gccttagcct cccaaagtgc tgggattcca ggcgtgagcc accacacctg gccatatgtt 60960gatatttcta agtacagcgt taactcttca aagtaattgg gaagaccaca aaagctctag 61020atgaaatttc aaatctccct cttcccccgg agaaatttaa gaactaccat cagaaaaact 61080tttcattcct caaataacat tttcttttcc cttttttgac aacgagagca atgcatttga 61140tcatgtttct cccctgcttt ttttttgacc cctaggaaac tcaaagccaa attcgtagcc 61200catccttaat gtctatgtgg aaagcagtag actacaaata actttccact agccttgact 61260ttttgtcccg tattacaatc tccttagtcc tggattttaa aaatacgtat ttctgtttta 61320ttcaatgtgt tcttataaac tgccttggaa tcttgtgggt taagttaaag attaaataaa 61380taacgaatat aaagatggta tcatagtttc aacattattt tcatgaaatt gtttgaaatt 61440tagaaggcac aagcttttgt ggtacagaga cctatactgc ctgagagtca ataaagaata 61500tactctggtc taccatccca ctgaggaggt cacctcccac cagaacaggg ctaaagagag 61560caaattacct ccatatgttg cctattaacc tcttggacaa atgattggta acacttagtg 61620tatgcaggtg ggaataagag caagcgcctg tcttattttt ttgagaccct gtcttatttt 61680tttgtgtgat ggtctcactg ttgtccaggc tggagtgcag aggtgctgtc acagctcatt 61740gcagcctcga cctcccaggc tcaggtgatc ctcccacttc agcctcccaa gtagctggga 61800ctacaggcat gtgccaccac acctggctaa attttttttt tttttttgga gagagggggt 61860ttcactatgt tgcctaggct ggtcttgaac tcctggcctc aagagatcct cttgcctcat 61920ccttccaaag tgctgggatt acaagcggga gccactgtgc ctggcctaga agatctgttt 61980tcttttctct gaataattct tgtgacactg tctctccctc catctctttc tgtttctttg 62040tcatttttcc cagctatcct tttttccttg tcttgtcctc ttctcccctc catcctaaaa 62100cctttgatca caagctagtt tcctttccac atcatctgct cccctctact aaacgctatt 62160tcgcccccac ctgctttcag ctgtgcttgc ctctgagccc ctctttcacc acggcccaga 62220tggggtgcac gtgccagctt ccctgtcagc agctcttgtg agcagcaact gctgctaaca 62280agcttcccga aaactaggaa aagagataca ccattaaata ccaagcagta atttggagac 62340aaaagaaaac atcacatctg attggaatgc cttacgttgc atccagatag tttggtagga 62400aggagaaata aaaatgtggc ggatagctag cataatgcta gatagcagta gcagtagaat 62460ctcagttctt ctgtcttttt gtaattagct cgttcgttcg ttcattcatt cattcattct 62520ttcactcagc aaccacttat ctgtgtctgt tatattgcca gtagtgtttt cttgggtctg 62580ggctttttga tgatagagct ttctgagacc tgggacctgg cctgggaatt tagtattcgc 62640ttgctttctg ggctggagaa agactgcctc taattataca gtttctccta tgcatagagg 62700ttatattcat aaatacagtg tacactgaat ctttatttta acaaggggtg tgtgtgtgtg 62760tgtgtatgtt tgccatgaac atacacacag tatattctaa aaattgtggg catatgcttc 62820cattttaaca agcttgaaat acagcaattt gaatatctga ttaagattat tcaaatacta 62880ttttactagt aaaaggaata aaaacctgaa gactaggcaa gatagaagac ttaaccatct 62940gcttctgctc tggggttttt gggaccttct cccaaaagca ctaatttaag taaaacataa 63000ttaatatata tatttttcaa tctacgtagt aaaactttta ctaattggaa caaatgagaa 63060ggaagacttg cctgaacata ttgaaagctg cacagtagaa tatgtaaaaa ggaatggcac 63120aagtggaaat ggtggctcag tagagagccc catatcatgt tgagatgaat aaggatagag 63180ctgaatagat gcatcatttt gagagggtca ctgccgtgag agtaagtacc agaaaaacta 63240gccttataag ccttatatat ggcttaatag aggtttaatg tttaagaatt tgataagaat 63300tacttgtgat tagtgcatta aagttctaac ctgagcagta ctgacttgac ttctctttat 63360attaccaata ctatttagag ataaatgggt attcctaaag tgtctgaaat gttctgtctg 63420ttaaggaggt cagtagtcta ctttgtcact tttttttctt taccagtttc atttttggac 63480agatggtaca atgctctata cacttgtgag catgtctcaa gttccatatt cgaaaaatat 63540gatttaaaag tgtttaggct agtgagaata acagagttaa gagtcataat tgtatttcaa 63600ttaatgaata cagttttggt gtgagctggg tctactttgc tttttagtag tccatattac 63660ttgatagtaa agagacatgt gcgtttcagt agtatgtgtt ttattacact tggaggtaac 63720ttctgtgtcc tttcaggggc tccacctata aaattaggga gatcctggca tgtcagggct 63780gagggtacac tcataacaca tcttgttttt tttaacttta agttcagggg tacatgtgca 63840ggtttgttat ataggtaaac ttgtgccatg catgtttgtt gtacatatta tttcatcacc 63900caggtattaa gcctagcacc cattagttat ttttcctgat cctctccctc ctcccaccct 63960tcaccctcca attggcccca gtgtgtgatg ttccccgctg tgtgtccaaa catatcttat 64020ttgtatgtct tattgaacct gggctcaggg aggtgaaagg atttattatg gcagagcctt 64080taacgggtcc agcacttttt ctaaattcta ctttgctgta ggtctgagaa aagcccagaa 64140gtttattgtg ctagaacaat gttattctct ctttcagaat caaaaccttt cagaacccag 64200ccttttcatt ttctaatagc tattcctccc taaaggatgc caggaggaat atgtaagtat 64260atttagatag aacgtatgca tacatctcca tgtcttagaa acacctccac ttccaacccc 64320atgtactgtt attttcattt cagaactgga attaggctgt ggaagcatct gaattgttcc 64380cctccctatc atcttttctc tttttacaaa tacagtttta ccaaaacaaa cccagttata 64440aaggcattac tggaaagttt actgtacttt ggatccataa atattctttt tttttttttt 64500gtgcttctcc tcactgttaa gagaagtctg ctggacaagg agttttgagt atgtgcattt 64560agtgggtaga tagtggtaaa aggaaaaaga aaaacatgca ctggcatgaa aggtagtagt 64620atacactcct ccgtttttcc tttaaagctt taagaggtag tgtggaatag cagaaacagt 64680ccttccctat atttctaaag atctgggttc aagacctggc ttttgccatt tacttgctct 64740atgagtcata tcacctctct gtgtcaatat ttatgtattc actcaccact tattgagctt 64800tgtctgtcat acactgcaga tacaacaaaa ctgtcacagc cctgccttct tgatgcttat 64860gttaagacaa tgatagtgac tgagaatggc gtagtagcag tgtaggtggc gagaaatcgt 64920gggatatggg acatattttg aagctaaagc tgatagaatt ggtgatggtt tagatgtggg 64980atgtgagaga aagatgtgtc aagactgact gctggggggt tttgcttcta caacatggtg 65040aatactggca tttactgaga gagtgaatgc tggggaggag ggaggaggtg tgtgttgatg 65100gtgtgggaat tccaggttgc tttttatata gatgatggtt tggatgcctg ttaacttcca 65160agtagagatg ctgaagaggt agttgggatt tttttttttt tttctttttt gagatggagt 65220tttgcttttg ttgcccaggc tggagagcaa tggtgtagtc ttggcttact gcagctcccg 65280cctcccaggt tcaaacaatt ctgctgcctc agcctcccaa gtaactggga ttacaggcat 65340gcaccaccac gcccagctaa ttttgtattt ttagtagaga tggggtttca ctgtgttggt 65400caggctgatc ttgaactcct gacctcaagt gatccactca ccttggcctc ccaaggtagt 65460tggatatttg agatcggagt tctgagatag aaatttggac attgttggca tgcatgtggc 65520atttgaacca tgcaacaggg tgagatcact tcagtagata gagaaaaagt gaagattgag 65580gcctgagtcc ttgggccacc gacatttgga gactgagaag tgggggagct ccctctggcc 65640tctgagaatg agaatgctgg aacctgacct cttttcctca tttaggttgt ttgtagggat 65700catgtgagat aggtacacat aaacacacat caaaaacaac ttagtgctta attgcatgac 65760taaatatagg agtaagggag gttacatgga taaatcactt tttcacttga tttttcttct 65820gaaagtctat tttatgggat tgggtgaggt gcgtgcaaat ttgttatatg gcagaggttc 65880ccaatgtgta gatgtgtaaa tgtgggattt aagggagtga agacagggag ggtatttggg 65940aaattttaca gggggcctac tgtacaatat ctgctttcaa tacgattatt tctttcttta 66000ttagtccaga aatatatata gcagtaggat ccatgagcta ttacctttaa caggattctc 66060atactaaaaa aatttaacac tgatatttga catatgtaga gctatgtaca tttataaaaa 66120catgtatgca ttctaaatgt gaatcggata cagttgacgt tgtctgcttt tgtggacaga 66180tatctgcttg gattcccagg ttttcgtaag ctgtttgaac ttgtttcatc tcagtctgct 66240ctgccccttc tctgtcaccg tcctcgcact ggagatgagg cagggtttcc tgaactgtgg 66300gctctgttct gggaagaccc tgtagccagc tcctagagaa gacttgcaga aagatgtggg 66360atgagaacag gaagatcaag tgggttgaag gggaaaaaac aagaaggccg aggcaaataa 66420aggcagagga tcatttggga gggagttgag gaaaggggcc tccactgttc cctaggtgac 66480catattttct ctccctcttt gggttatttt ctttgtgcct acctgtttta tcagaattgc 66540aaggattttt cccaggtgtt tgggttgttg agtagtaggt aaatataact ttttccgggc 66600attaccttct ggaatatctg cttgaaggta aaattgcaaa aatggctcat tctcccctac 66660ttttatgaac actgttttag tctaatctta ttatattgaa atcttagatt ttatcccatg 66720cttgtgttta tccaatttta tagggtgtgt gtgtgtgtat atatgtgtgt ggggaatgtg 66780aatatatgtg aatgaatgcc ttttctagag aatctggtat attaagtcat ctacccaaga 66840agaaaagtct tctgagattg atgctgtcag ataaatctat agaatttgag aaatgaaaga 66900gagcatagag aacatctgat ccggactttt ccaaatgtat attccattaa aaaagaagtg 66960ccttggtctg atgatttttt tgggagttgg agactcactg catttattaa ctatgaaagg 67020cttaagagct cttgctgtta aaaatattat ttaactatgt ttaaccagtg tttctccaat 67080tttttcacta tggaccctca ttttccttct ctctcttttt agaaggatat gtacatagaa 67140cagttactat cattgcacag aagtacaaga ttccagaaaa cataatttgg gaatgctaat 67200ttaattctta ccttcaaatt gaatgcgata cttcatttct gttggtttgt gttcccatat 67260gtagtatgag caggttgaat gaattaatca attactgtgt cactcctgac tgtgacattt 67320tctggttctg attcgttaaa tcaatattta aaaattatat ctgtttctat attaaagaac 67380cttgtctttt ttgttcctta ctagaaccat agtgtctaat acagtgcctg acacatagta 67440gtgtctcagt aaatgttact gaacaaatat atacctgtta gattcagagc actgaactag 67500ctatgtcttg aggctgcaga gagaatgatc ttgtttttgc tctcaaggaa cttgtagtca 67560agtcattaac tttcctaaga gcatggaatg tgccatggag aggtcccaaa ttagagcttg 67620attgtgataa tctataggac aaagatagat tggacattat ttctgaccct gtgtcagatg 67680tgtggattac aacacagctg ggttatgtta acataacttt catgacaaga agtgtctttc 67740agtaatagtc actgcagcag ccacatagtc gttttatccc tggcaaagac tttatgatgc 67800tatcagcact aagagattgg agctagtatt attcccattt tagtagataa aagagctaag 67860gctcagagat ttagagacat gtctaagttg acatacctcc tgactgaaaa gccagaatta 67920ggacccaggt atgtgattct aaaccttgtg cacttatcca ctaggcttcc tgtcctctca 67980ccaatactag tatctttcat tgtctcattt gtattagaag ctcaccttga acaggctcag 68040agaattacac atttccagtc ttcattgtgt ccctgctctg ctccctctgt ccccatgcca 68100tgagggctgc tttctttaca gctgatgtgc tagctagggt gagttttgga gcaggtaata 68160aaaagtttac agactttggg ccagatgcgg tggcttacac ctgtagtccc agcactttgg 68220gaggccgagg ccggtggatc acctgaggtc aggagttcga gaccagcatg gccaacatgg 68280tgaaaccccg tctctactaa aaatgcaaaa attaaccagg cgtggtggtg catgcctgta 68340atcccagcta ctcggaaggc tgaggcagga gaatcgcttg aacctgggag gtggaggttg 68400cagtgagctg agatcatgcc attgcactcc agcctgggtg acaagagcaa aactctgtct 68460ctttgtcctt accaaccatg ttggcagcat ccatattcta ggctgcagat aggagaagga 68520attaagaaaa cggggcaaag accttacagt ggtctccagg gtagaagctg ccacacagta 68580cttttgcttt tatcctgttg gccaaactta ctcacatggt catatcttgc cgcaaaggaa 68640gctggcaatt gtagtcacta ttgtgagcat tcttgtgcac agctaaaaat tactgttgaa 68700gaagaggaag gacaatggca tacaatcagc tgtctcttcc accactgcgt attggggtct 68760ggtgcccatt cactcccctc ttctgacttt tggctagtag ctaatccttt tccctgtcct 68820tacctttatc ctttaactcc cttcttccta ttatttaaat gttctcaagt ctcttccatc 68880ttaacatgcc ataacacaca cacacacaca cacacacaca ctctctctct ctctctctct 68940ctctctctct ctcacaaatt catgagtaaa ggcaccatgt ccccagtgct catgttatat 69000actcagatcc ttgtgcaggg catagtacat aggggttttt caacaactct ttgttgagag 69060agcaagtggg tgagtgaagg gttgaaacat ttccctctat cctttatcct cggattgaca

69120gagagatgct gctgtctgtc ttaacatcta tggcacaaat gacaggactg atgattttac 69180tccctttagt gctgaggagg ctgtttggga ccatgaagta gttctagaaa tgtatcgtgc 69240tgagaagagc actaaaggga gtaaaataca catcagttct ggttttgttg cttactagct 69300acaatgacat ttggcaaatt atgtaatgtc tttgagcctc agtttcctca tttgaggaag 69360tgaagactcc attgacctca caatgattaa attagaaaac tgtgataaag aatacacccc 69420tgataatatt attttggctt cttatggtga tttttaagat taaggagtat catcatccct 69480attttatttc tctaaaataa tatttaaaaa aacgtaaatg ccctatacaa tagagtatta 69540tttggtcaca aaaagaatga agcactggtg catgctacag catggatccc ctgaggacat 69600tgtgtaggtg aaagaagcca gacacacaca ttatatgatt caatttctat gaaatgtcta 69660gactaggcta atagaccagt ggttgctagg ggatgcgata ggggagaatg gagagtgaca 69720tggggtttct ttttggggtg gtgaaatgtt ctggaagtag atagtgatga tggttgcact 69780cttttgagat tacactaaga accactgaat tgtgcaccta aaaaataagt taaaaattta 69840aatgtcatta tagggcatta taattataag taagagaata cttttaaaac tgtgtctaag 69900ttttggttca cagtttgtca atgattcttc tgtaacagaa accaacatct ggttggtttt 69960ttgagttttt tcacctgctg gctgacctta cttgacatac tgtattagac tttctttatc 70020tttccaggcc tacgcaactc tcagcacact gggaaatctc agggcatggt gttccattag 70080aaagaagagt aagcatgtgg gcttcttcgt gggtaccatg atgggagaga atagaaaata 70140agaagttaaa taattcctcg caattctgtt aggcatataa actacacatt taatattata 70200aaacagtttt ataaatgcac ttggtctatg gtgtctgcat ggattaggtg agtacttctg 70260gaaggaggtg gggatagtca gagaaggcat gctggggaag gaaatgttta aacatttgct 70320tcttacacag acatttattg aatatctggc atgccttagg cattgttatt tggtgttgta 70380tgtacccaga taacagctgc agtccctgcc ctcagggtgc tcaaagacag cgaagacaga 70440tgattctaca gacagttagg gagcaggatg taagtgctac tccaaaggta agcacaggac 70500tctctgaacg cctcacttgg gaaatgggag aagtcaggga aaccttgatg gagatgattc 70560ctgagctagg aactgaagga tgagtgggga cagcaaaggc ttggaggaca aagtcatgct 70620ggattacagg aactgcaggt aactcagtac gtttggagtt cagggcacaa atggggatga 70680gccatgagaa gttgattaca agtagccttg taagccatgt cacctaagag agtaagaaat 70740aaaagagttt tagagcatga tacttccaga ttagcagtct agaaataaga ctggctgcat 70800tgtagagact tggaatagaa gcggacgaga atgaaggcag aaactttcag gagattgttg 70860cagtaatttg ggagataagt gggtagagac aacagagtta gaacagagac aacagagtta 70920gaacgattag ggcttgctcc ccaagtggat atggtcgcag ttcctaggac tccaagatct 70980ctgtccactt cgctgtctca cttcatgtca gtctgacccc agcctgcctt ctaagtcttg 71040ttttcttctc ttcatgaaat gcttaagtct tgtgcttact gtccccagaa ctcgcttggt 71100gatttaatgt ctgttacctt tgattacacc tttatcttca cctagaatgg agctcatctg 71160ttccctttac cttcttagat ctctgactta tgaatccttt ggaataattc catgctagaa 71220tgatctcttt gtcctctgaa gtcatagcac ttaatatctc tatcagtcaa tgacaaataa 71280ttatgttttg ccttgtcaca tctcttaatt gctttgaatt gctagtcaat cttgagccat 71340tgcagcaggt agagaggtga attggctctc ctgaattcct actcccagcc ctaatttcct 71400gtataaccca gggggaatga cttttctccc ctcattagtg tagtaacaca tatttgatgc 71460agaacactta gaaaatctct aaaagtgtgc aaaatgaagt aactactatc acaaacacct 71520tggaatactc acaggtaatt attcttgtaa tgtcctcccc atccattttg tcaccgtttc 71580tttaggatta catgtgtgcg tctatgcatc atagctagga tcatcctata catgctgttt 71640ttcaatttga ttttttcatt accatattgt aagattcttg tgtcaaaaca taggagaatc 71700ttcaagtcca aattgaaagt ggagctaaat tgttctcagg gagagttgta cagatgagta 71760tcccctatct gaaatgcttg agaccagaca attttcagat ttcagatttt tgggatttta 71820taatattagc actatgctta cccattgagc atcccaaatc tgaaaattca aaatcctcca 71880atgagcattt ccttcaagaa atgtggtagt caaaaagtca tattttggag catttcagac 71940ttcagatttt ttgatttggg ttgctcagcc ttaccaaaaa ctgaatagtg actatctctg 72000ggaggaggga ggggaacttt ggcttttcag tgatatcttt ctataatgtt gaatgtgtgc 72060atttatgatg agtctaaatg atttttagag ttgtcaccca tagtttatag gtgacagtaa 72120tttatacttc tacctaatcc aggcttatat ttacatttaa aaagaagtat aacaccaact 72180ttactgacta gatagataaa caattttaat ttactgaaat ttcacctttt caccatgatt 72240ataggtcctt tttccattag ttgtttccat ttcctttgct gtctaatgac ttagatttga 72300gtcctaggta ataaatacat gtgatctttc acaagtcact tagtgtttct aagctttagt 72360ttgcttatga gtagaataag aggaatgata cttcaaatta ttgtgaggat tgagatcaag 72420tattgaaagt gctttgtaaa ttgtaaaaag tatataatta ttgatttttt attgattttt 72480atattagtca atggtcatga gcagttaagc caactttgct tttttaaaaa ttcatttgga 72540gaaagactaa aaaggcagag gtgccttcat taatatttat tttggtgcaa tgtgggatcc 72600atgagatttg ggtttgtgcc acatttctgc tgctaattat tagctatata tacagctgaa 72660atgcactgaa caagcacagt tttggccagg cccagaaatg ttcagggagc acctggctgg 72720acatacatca gagagcttgg tgacctgata aagcattcat gcaagctcct ggagactgtt 72780taactggatg acagtagaag gaaactattt atgcaaattt tgctaactga agttctccca 72840cacccttgag tccacatttc acaggcttgt gagatggaaa tgggtcaaaa tcaggttcta 72900ataatctctt tgtcatctgc agtcatgcct gagaaggtct gatatggtct tctgaatcat 72960caagggaagg tagaatttca tccaacatga cttttgtgca tttgctgtat tcagctccct 73020ggaaacatag gtgccttaat tttatcagtt atccagaaca ctgaattctg gataatagag 73080gaacagggct gtgtaaacaa ctctgctgag taatagatgg cctcctggcc tctggtttct 73140gactctgtat tcccttttat ccaaggacaa gatgttacaa aaataattca gagtgactcc 73200caagggcagc cccgtgaact tgctggtccc tccgactgtg ctagcagagg aggatgagtc 73260accagcagca gaatgttgac tctcccagtg ctattagtgg atgtcccagc cagacgcgac 73320aaccaggaag acaagctttg ggaaagttct ttctgactca ttaacatcat gatttacaca 73380agaaaacctc tagcttctca ttttatttta ttttttaaag aagtttcctt tttgtatgtg 73440tgtatagcga ggtggggcaa aggtatggat ccctcaaatg aatattcaaa ttagctctta 73500cccatagcag tatttgaact gtttgctcag ttaaatttta ttgtcctttc tcaatgtaca 73560gtgcctatat atccatcaaa gagtagcaga ttcattaaga atctttaaaa agaaggacat 73620tatttttaca cagttgaatt tcaggtgtcc tatgcccatg cctttcccat catttcctat 73680gtgtgagaac ccccacccca cgtagcacac cttcacatac tggggacttt ccacttgagg 73740aattcacatg aatctgggga tctgcattct ccttgggtag tatcccctca gaagaaaatc 73800cagactcctt agggggcatt tgtagcctgg gcccagtttt cctccttacc tcatcttttt 73860tggttctaca caaacctgtt tagtcttcag tcaagtgcct taccctccgg ctttcctcct 73920cctcctcctc ctcctcctcc tcctcctcct cctcctcctc ctcctcctcc tcctccctcc 73980ccctccccct ccccctcccc cctcctcctc cccccctccc cctccccccc tcctcctccc 74040tcgtcctcct gctcctcttc tttttttttc tctttttctt ttgggatgca gtcttgctct 74100gttgcccagg ctggagtgca gtggcacagc tcactgcaac ctccaccttc tggtttaagc 74160gattctcctg cctcagcctc ccaagtagct gggactacag gtgctcacca ccacacctgg 74220ctaatttttg tatttttagt agggacaggg tttcaccatg ttggccaggc tggtctcaaa 74280gtcctgacct caagtgatcc acccgcctcg gccttccaaa gggctgagat tgcaggcgtg 74340agccatcgtg cccaacccca ctttccttct tttgctattt cttcatgttt cccttatttg 74400gaatgttgtc ctcactcagc tcctgttttc atcctgtttg tatcccacct tcttcgtagt 74460gatagtagta gtattgcatg cctgctgtga gccagttttc ctactgtgtt tatgtatata 74520tttttccaag agtttaaaat aagcctgtaa aataattatg attatcctta tttgcaaatg 74580agaaaacagt catagaaagt taaaaattat tcaaagccag ctactaagtg gcagggctga 74640ggttttcctg agcctgaaca ttcaacccca ccatgctggt tttccctgcc gtcctctgga 74700tccgatcaaa ctcactacac cagccccact cttagacctt ctccagacgt gctcttttcg 74760cttggtcggg tgtgtcctgt gtttggcaat cagtcatgta ttattacctt gctatgtgct 74820tgggttgcta attcttcttt ggcgatatat cttttgttgt tttcttttct tcttactgag 74880ctgtgcatcg caggctttac acaatgcgtt tttgttgatt ttacttaatt aatgatgtcc 74940tggaacaagt gagttatttc tcctagttat atttagccca attagttatt tacatcctac 75000cataatattt gcctccacta attgctaagt agtcttgcaa attatccttc agtcttcttt 75060ttctatgctt ttattcctgg gaaggaaaga caaaagaagc tccgtggctg gagtctgtag 75120tgtatcccat cccctgcaaa gaaaccaaca gaaaaattaa gtggaatgac caggcattgc 75180cactaaatag tttgatactt tgaaatggat gccagtttgg ctaaattcaa gtgttgtctg 75240ttagacaagg gctattcgta aaagaattgt gaatgtaagc atgctctgga ctgtgcttca 75300aggatgcaaa aaagtgtcat tgagactgcc ttcctatgtg cagagtggga aaaggagcat 75360ttatcttgag aaagaataac tgcatctgat caccgttttc aattcattga tagggaaata 75420caattaaaga ttcctaacct atttcaggat acccatctac catctaaatc tccaagactt 75480ggatagcttc cccgttcccg agtagttccc cattgacagg catgcactga actcttcatt 75540tacgataacc gttgtttcca tgaaatacac tgaaaatttt gcacagttgc aaggtacaca 75600gaatggattt tgaattcttt tggttgtacg aagcatccct agatgtgatc atgaagttag 75660acacctggga ctgtgagaaa ataagtcatg tgtaagaaga gtggtttggc agaattttaa 75720aaatagacct tccatgcttt gtgggtatag tttctacata ttctagatct ttgtggtacc 75780attatatggc tgtaggaggt aaccaactga agagctttct gggaggagaa gcttattgtg 75840aaatgaagac tgtgcatatg cgttgtatgg gtctcagtcc agctgtttgt attgaaacat 75900cataggctat acattgtgag aaaagagaag taatcttgtg gtaaccaaag aagtttgagg 75960tgaaatatgt ctcactgttt catattcagc tggggaatgt ctcactgttt tatattcact 76020ttcttatatt tgctgaaata aaaacaaaaa taaggtaaat ttgattagta gtaaccttgt 76080tgggtccttt aaaacagtgt ttttcaaact gtagtctgtt aatctttact gggctgtgaa 76140atctgttttg tgggtcttgt ttagcattta aaaatgtatt aaatataaga aaatgtagaa 76200tagaaggtag agggaatggc acatagtaag gatcaatatc tttttgtgaa acttgtatgt 76260catatacaca catgtgtact acaaaatata ttttttacgg tggatcatgg tcaaaaaaga 76320ctgcaaagct gttttaagca tggctgtcag cataggttcc taggatatca gacaatgatg 76380tgtaacccta gctggattct tggctgaatg ctaggggaaa ctggggcaga ctggggagga 76440gtgagaggtg gcacagtggc tccagaggcg ctgtggtgac ctgccgatcc tgctctgccc 76500tgatgctgct gccgccttgg tgaagactaa gtgcattact cattatatgg atagggttcg 76560ctgagagctc tgccagcagt ttaagattgg agtctttgtt ggcagggcag tttcaaagct 76620gaacataaaa actggttaca gttttttggt tgagggggcc aagtgtaggg gggccatgta 76680gagaaagatt tttcttgaga tttcctggtt tttttttgtt tgttttttga gacgtagtct 76740tgctctgaca cctaggctag agtgcagcag catgatcttt gctctctgca ccctctgcct 76800cccgggttca agcgattctc ctgcctcagc ctcctgagta gctgggatta caggcaccca 76860ccaccacgcc cggctaacct tttttgtttt ttgttttttg ttttttttag tagagacggg 76920gtttcaccat attggccagg ctggtttcga actcctgacc tcaagtgatc cgcccacctt 76980ggcgtcccaa agtgctggga ttacaggcgt gagccattgt gccccgcctc gttttgtttt 77040gttttctctc ctaacttaca ttttgaggca atagctgagt acctttggtg catagactga 77100aatggacatt tgccatttgg ggggttgtct agcattggaa ccccctttgt ttctagagtg 77160gtctcccatt gttgctgtgg aagctgaagg aggtgcagac acataactga gggcaaacta 77220ggttcaacct cttcgattcc tcctcgtcag gactttgaat ctggagggag tggtgcaaac 77280atacagaggt ggcttgagat cattcatgga agcagcagag ttgggagtcc agtcctggtg 77340atggctggtg accggtggag gctgtgcgag cagtggtgtc cttatcaggc tgttcctctg 77400tccttctgtc tttcccttaa actcatttta cccttaggta agcagagctg gtttctgttg 77460attgtaccca agaacactga gtggatatag gaagcatgtt agatttgtgt ctgccctaaa 77520tgaacttagt atgtgacagg tgagaagaag taggtgaatg cttggtagac acaaatagta 77580aaatttagca aggggtggaa ggattcaggg ttgttttcct ttgtattcct ttaaattatg 77640ggtaccttca agctttgtca gatgacttat cagcaggaga ttctatgtct ttacattgtg 77700acattttgga aatacatgtt aataaaaaat gagctatgtt aggtgcagta caaaatggtt 77760tcaaactttt ataagttagg gtttgtttta tttgtttctt ttttcagttt taagcttttt 77820aaaagccttg cgcatactca cagaaaactg atttcctaat gggtgtgagc attttatttt 77880agcattaaga gatttaggga aatcttgaat catcatcaca acaaccctgt aaagtagata 77940cttctattat tctgaggaaa caaactcaac agaggttaag aaactggcct aaggtctcag 78000acagtgggtg ttagagctgg gatctggacc caggttaggg tgactccaag agcaggcttt 78060taactgcttc tataaggaac tttggagggc atccaatact ttttcattat gcagggtttg 78120agctcagaga ggttaagagg cttgctcaac accaggcagg tcctagtgga tctgggctgg 78180aacatgggcc tctttctgac tggtgggaag aagctctcgc acaagctctg ttcctcttgc 78240accctcccct cctttccttg ctgtctgcct ttttcctgca agattcttcc tgtctgcata 78300ctctttcctg cacaattgtg cttgtgattt tccttcttcc tggcctttat ttttattttt 78360tttaaagaac agctgtacct ttcctctctc tttttcagtc ttctccattt ctgaaaactg 78420agagcagatt cctctctcct taatcccctc tcagcccaaa gcatggccct tgtgtcctct 78480gtttttgact cccatggttc tcagtgtctg tctctcagca tgccctcaca gcctcttccc 78540tggggttccc gtgtatatgt tagtcttgcc agctgtcagt agattgtaag atttttggca 78600tgctcagatg tatttgtgtt acttctttgg attcccctga agtcccacac cttgcccaag 78660gcagagtggt aaatggaaag gggagtgagg ctacagctga gaaatgtgtt tgagacctat 78720ctcacctctc actggccagt tgactgtggg aacgccttag ccgagtcttc ccatctgaag 78780gggctgtgaa actcgaatgt ggtttagatg tgaaagccct ttttaagcca taaagtgcta 78840tataaatgca aggttttatt gtgatggcac aagtgcttca gaagtatttt tgggataaat 78900gattaaaaag cacatattgt gcctgggtga gttggttcat gcctgtaacc ttaacaattt 78960gggaggctga gatgggagga ttgcttgagc ccaggagtat gagaccacct tgggcaccat 79020agtgagaccc ctttcccaaa aacaacaaca acaaaaatta actgaatgtg gtagtgtgca 79080cctgttatcc caccttcttg ggaggctgag gcaggaggtt cacttgaacc caggaggtca 79140aggctgcagt gagccatgat tgtgccacta tattccagcg tgggtgacag agcgagattc 79200catccccctc catccccccc aaaaaagcac atactatgaa gacaagccat tctccccacc 79260ccgccatgtt ttgagtgtcc atttgtgcca ccaagtcttt gaccctgggg taaggatatg 79320gatggcttca ctaaatctta tattcattgc tctttaataa gattatggat gtgttagtgg 79380taattagttt aaaagaagaa aaagtttttt agaaaaggaa aagtaacaaa gtctcttggt 79440acaatgtggc ttttagaaag acacttactg actttaagca aagtactgta tttactttta 79500tcaaaaactg tctctcactg aatgcaggct ccttgggagc agtgcgaagc accgaaccat 79560tgagctggca ttgattattt aatcatccct agtttattgt aaatgaagca gcacttacgg 79620ttctggggta ttcctggaat tgctgctata gttagaagtg agttattctg tgtggcagga 79680gtggcatata gaaaagccat agttctgact tcctgacagg aaaaatagca gattttgtat 79740ttatatgatg tcgtcctttt ggctggaatc catcagcttt acagtatctt gtgatgcttt 79800catcagaact gttattccac gtctcagcat agcagtgggg tcccagtagc aatagataca 79860agtcattttc ggtggctcta tgggtgtgaa gccactggca gtttccctgg cttgttgtgt 79920aggttaggct gttaggaggc ttcctgttca catgttgcta ggactttcct ctcacactgt 79980ggcagtggtg ccagggcaga gcattagtag tgggcaggaa cacagggaag gctggggcca 80040tgcagtgatt ttttaaatga cagtcctttc agtctacaga aggaagagtg ttggagtaag 80100atcagtctcc tgggtggttg ttagactatg aaaagtacta aaaaaccaga gaagacagtg 80160gtgttgctga tggggacagt ttagagcagt tcttccccac tgtggaacga gcagggtcct 80220tagaatcagt agtcacgtgt ttgactcctg gcactctcgc tgattagcgt aaaacctctc 80280atgcttttta tgagaattaa gtgcgagtgc ctaactccag gctcaagata ttgaaatgct 80340tagtagatat tgtttttttt ttccttgact ggaactgtat atttcatcaa gctgtaatca 80400gtttaacaaa ttatggtcaa aatatgagtg cttactgcat gctaaactct gttgggcatt 80460ttacatgcat tgactgactt aactcttaat agcccagtga gataaatgct atttttatct 80520ccccacttac accaagaaca ttgaaggtta gggatattaa ctaacttgcc taagattaca 80580atagctagtc ggtggagacg ccagaattca aacccaggtt gcaatgactc cagcccgtgc 80640tcttaactgc tttgctgtgt catctgagct ttatgaaatg gggttttgat ttgtatctag 80700gcttttgctc agaatcccta tttagacttt gctcttcgaa gcagattcat agcccacttt 80760agtcctgtgc cataaagact attttatatt gcgtcaatac ctttttgtac acttacacat 80820ctatagcctc ttgcaaaaag ggcattgtag gtacttgatg aagagttttt gaaagttgtt 80880tgtttttaaa aagagacaac atcttgccat attgcccagg ctggactcaa actcctgggg 80940cttaagcagt tctcctgcct caacttctca ctgaaagata tttttaatcc ttgtaccaac 81000cctctaggca ggatgtttcc tcttaggtta atgggtaggg aaactggctt agatgaaaat 81060gacttgctca tggtcacact tgctagtata gagttagtgg gaacctacac accttggatt 81120actgtgcttt ttttcattgc ataatgttgc ttactttgta ccttcatctt tcatttacag 81180ctgttaccga acatacttct tgatcaccta atttgtgctg aggataaagc actaaataca 81240agacaaaaaa aaaaaatcct gatcttcctg tagttttcat tgttgtgtta ggtttcctta 81300ccaacgttaa gactgctgcc tgctgaaata gttgattaag gcttaagatt tttagtctta 81360aaatttctta agatattaag aagctgattt cagggcattt tctaaattac atatttttct 81420ttcagttttt ctgagttcat accttaattc ataaacattt tagttgtatt ttctacttca 81480gaaatcaaaa ggtttgattc ctttaaggca aacacaaagt aattcattgt aggtgtgatg 81540gtttctttta tatccatagt attttaattc ttgtcattga gtttcactgt caaccagtct 81600gtttttaacg gtaaaaatct ggcagtggcc cttggccaaa gtggtctcat tctgatgatc 81660atatttatga acattaaaat agtctatttt tatttccttg tccactatcc aaaatgtgtg 81720ttcttccctt gcgcagatac cagtctttca aaagatgccc ttgaaaattt aagagagttc 81780cagttttttc agatagattt ctggaatttt gcatcttgga aaaatttctg acattttatc 81840tattgcagtg aggctttgtt ccaacccaca gaattgtgtc ttgtttcttt tattttttcc 81900cttgttgaga aagtgtcaga tatacttgtc ttttttataa gactgtggta aactgaagca 81960atttgagtaa cccacaaaat ttccctgatt tttttttcat gtaaaacagc acctacaaaa 82020ttgagctaca aaagtaatcc tctgtcacca aaagaaaggt attttctttc aaatccttga 82080caattttata aataaattcg ggtggaagaa ttcactgcta tcaccaaaaa ccttctgatt 82140actcttcctg gtccttcctg ttttctaagt gtctttatat tcatttgagt tgggaattga 82200acccagtgaa tcatgttctt tttaaagggt attttgtgat tgctcctggt gaatctttct 82260agcattgatg atttttcctt ttgtatattg cagcaagaaa cttgaattta tttcttggaa 82320ttatccaaag tgtttattaa tataaactga tcttgctcct tttctacttg ctctaaaaat 82380aatcagctag atcacattgt ctggtttatt ttagaagaaa tattatttgg atgaagccat 82440tacacaaatg ctgtagcaca cacacaaaaa aaccgcttgt catcctgaat gaggacagtt 82500gtcatttcat ataaagtgga tcagcagcct taggtttaaa gtgcttagaa cagtgcctcc 82560catgtcttct aagtgctatg tgggtgtttt ctatttttat catcagaatg gcaattccct 82620gagagtagag attttgttgt tattgaatcg gcattcaaaa gcatcacagt taatgcatat 82680tgtcttgaaa ttctgttgct gttcttgttt tctcgaagag tttaatctct aggctaagca 82740tcacaaatct ataccatttt actgttgtgt tcaataatac tggaggtcag tttgaagatt 82800aggtataatg tgattgcaat gtagtattgc ttgcagaaga gacagaatga ttggaaaacc 82860aaactcccct tgattactgg tttttgtaga attctagttc taaaagaatc ttagtgattt 82920tagtcagatc cttgaatctt acatgaggct aagagaagtt ccatgactcc taagttgaag 82980taacacatgg tctgatagtg catattaaaa aactttttaa gttctggcca ggtgtggtgg 83040ctcacgcctg taatcccagc actttgggag gctgaggcgg gcggatcacg aggtcaagag 83100atcgagacca tcctggccaa catggtgaaa ccctgtctct actaaaaata caaaaaatag 83160ctggacgtag tggcgcatgc ctgtagtccc agctactcgg gaggctgagg catgagaatc 83220acttgaatct gggaggcaga ggttgcagtg agctgagatc atgccactgc actccagcct 83280ggcgacagag tgagacttag gctcaaacaa aacaaaacaa aacaacaaca gaaaaacacc 83340tttgtaagtt ctaaaaaggt ttatatggta gcccttctga atggagcctg ggcctggtgg 83400aacttacagt tctcttcctg tcctaaaagg ctgagttgtg accctttccg ggtttgaggc 83460atgcttttca gtactcccct ctggtcagtt ttcactgatc cttggcagct ggtaacggta 83520tgctgtgagg aaacctgggg tagacaggct ccagacatgc agttagcaag cactgcctat 83580ggactggcta gtgctgttgg gtgcccaagt gtaaaaagga gtattgtgag gttttcctgt 83640tcaagcaacg ggagagacaa gcctagctcc tttctgctat aggacctttt tccccacaca 83700tgctgatcct tttgctgaga ctgctatctc cgttttggct tcatgcccca cctccatgga 83760catccattgc atcttaactc aatgtccctt ccctcctgag ccccagacca gatcacattc 83820cctctatttt atgttctcta cttttccttc atagcatttt agctctttgt aatgacctct 83880ttctgtacat cttagtttga ttccattctt cccattgact gtaagctcca cgtaggcagg 83940gaccgtattg cccttgtcct ttgaattagc ttagtttctg cagagctgtt tgaaaatact 84000tgttgaaaga gtgaatctct tcaacaagta tagcatctga agtcctgctt atgagcagaa 84060gcaaggcatt agcatgtagc tagtttctaa gtgctgttct gaggcagggc agggtgttta 84120ttcacataat taaaacaatt gattatatta atttttaaaa aacttttgtg cagtgatttt

84180aatcttgtta aaattggcca taccaaaata gccaaatcaa agtcatcaca atcaaattca 84240tacttgtctc ccctgccggg ctttccatca ttacttttac ttaagtctta cccactgcag 84300aaagccttcc caagccagcc cttgccagtg tcagtcacca gagctaacaa catcctgacg 84360cactcacact attgatttta ggttgctttt gtgtttccat ttgtgctgtc tccaaccttc 84420tattgtaagg ccctgtgggg atgctggcct cgtggcctca gaggtaaccc atctccctct 84480cccccttcgc tgctgccctg taatgcctgg gactatgctc ttcctaaaac tggattctga 84540taaaatgtgt tgagtggcca gacagaaaac tgaggtgata atcactgtta atttgagaac 84600caattttgaa tcaccaaggt tggtagctta ttatttgcaa aaataattgg attctactgt 84660taaagaattt gtgagaagca acaaggaaag ctgttaaaat aatacaaagc tctgtgtgtg 84720tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagacaag gttggggcgg ggtaattcta 84780gaaggaatga gaaattaaag tgcgcgtttt tgggtgtctt aaactattgt tcacacaatc 84840aggagagggg ctgttgatgg aaaaagcaca caatcttcat ttacattgga caggacactc 84900catatcggga agcaaaaatc cctggcttcc tttcttgatg cggtgaagtt agtatcctct 84960ttgatgtttg caccctaaga tgtctctctg tcctctcgat gtcctaggcc atttttttgt 85020tttgttttgt ttttttcctt cttcctctca aatgcttttt cttgcctgct tatggtttgg 85080gctgcttcct taatgaaaat gccctcttat tttcagatgc aattacctct gccactgatt 85140tatttattta tttttgtctt tagcgcttct ctgaagtagc tttggaaagt agagaagaaa 85200atccagtttg cttcttggag aacactggac agctgaataa atgcaggtat gtagatttgc 85260atatttttaa aaaaggaaaa tatctggctt taaaaaaatt gatgaaaccg tgttcttgag 85320gctgtagggc tattggtgct attgccttta attttttgaa attgatgtat ttattcattc 85380ccaatgttga gtatgctggt taaaaaaaac ctcaaataca aaagtatagg aggtacagag 85440taaaagttaa acttcccttg taatctctcc tagatgttca ccactattaa gaatttattg 85500tacgttcttc tagattttaa tatgcatgtg cataatcata ttatacatgt tgtgcatatg 85560catgatcata ctatccatat tatgcttttt tcattttgca gaatgtcctg tgcatctttc 85620tgtgttgatt catatgcagc tttatgttat cctttttgac agccacatag tagtcctgcc 85680tgttttgttt agtgagtcct ctcctactgg acattgtcag ttggattttt ttcttatttc 85740tttttttttt ttgagtcgga ctcttgctct gtcaccaggc tggagtgcag tggtgtgatc 85800tcggctcgcg gcaacctccg ctttcccagg ttcaagcaat tctcctgtct cagcctcccg 85860agtaggtggg attacaggcg catgccacca cgcccagcta atttttctat ttttagtgga 85920gacaggggtt tcaccatgtt ggtcaggctg gtctcaatct cgtgacctcg tgatccgccc 85980gccttggcct cccaaagtgc tgggattaca ggcatgagcc accacaccca gccgattttt 86040tcatatttca aacaatgtga catcctgtaa atatataatt acatgcattt gcctgtttat 86100ttccttagag ttagagggtg caacactgtc tttggattct tcccctgtca cgtctataaa 86160gactctcaag gacaaaggtt tatcttacat tatgaagcag gcttttagct actctgtttt 86220ccatcacagt ttttcaatgt gggatggggt taggggttca gtgctgggtt ttcaagtggt 86280cttgcttgtt gatctgaatt tcaaggttaa ttatgaacta actgtttcag gctggtttcc 86340agaagattct ggtcttcaga tttatttgga aattaaacag ttaaaattga atacctctca 86400gtttgtagca ttgaggcata tctggttaat gtccctcttt tcagaatctc tcctcaccag 86460gggagctaat agaccaagca aatgaatttg gtgaagagaa ctgtgactgc tgtctgccct 86520gtatgacttt tcttgtttgg gggagcctcc ttgggtcatt ctgcaagcac ccattatgtg 86580taagcctctg tgcttcttac ggatatagag aaaaatgact cagttcttat ctcaaggaac 86640tcacagcatg tgcataagat gcttaaattt cctgtggcta gtgcagtggg ataagtttag 86700gagcaagaag cgagggcctt agggaatggg atggaggttc agagatggct tcctgcagga 86760ggcgatatct gagctgaatt ctaaagaaag ttgaagtttg ccatgcaagg gataaggtag 86820aaagatattc ctatagagga atcagtgtga gtgaaggcag gagggtgaga agtagcattg 86880ggtaggggag gatacagtaa cactgacagc cttgtgggtt tcaagcatga agcaagaagc 86940tcagagtgat agaagataag gtgaggaagg ctggccggcc agatgatgga gcagggctct 87000gtttcagagt ctcagaattg ctctgtagat taatgggaag cccttggagg atctggtatg 87060tgttatggag aaattacttt aggggtttaa gtgaaggttg gcttggcaga caggaagaaa 87120gtagtaggag tgtggggtca gcgaattagt ttgtagccca ttggtattgg gcaagaagaa 87180gaaagaatgt gtagggcttt ccctcatttc tttcctcctt tctggccttg cccaaggcta 87240agttgctgag gttggttctt tggccctagg tgctctccct ttggagggtg cttatgtgaa 87300ttacttactt acgcactttt caccagggtt ttctaactgt tccaaagtaa ggcctcctcc 87360tgccctcctg gtgctgcgtc aaagtcctgc cgctcctcct ggggtggtag gaaccaggct 87420ccattcatta attgttatgg cccttccatg tgacttatga acatgaattg gtcatcattt 87480tgtgtgcagt gtctcaggtg gggatgtgaa gagagataag atacggttca tgccctcacc 87540atgcttgctt tttagtggga gatggacatg aaattaaaat gctgattctt gccataagtc 87600tgttcaaagc ttatgtgatt ccagtagaaa cagcagcaga atttgtaact aataatcagt 87660cctttaacat tgttggttcc agaatgggct acatttttca attacaactt gggtgcaaat 87720ggagaaaata aattcaggcc atgtctaaaa ttattctgat ttttgaaaat atggtctgac 87780catattttca aaaatacata attaataaat tacaattcat taattagtat gcataattat 87840tttccatggt ttcatctctt atgagatctg acatgtttgg tttccaggaa gggaaggggc 87900aggggagagg tacgtatcca ataccaacac caaatgtttc tgctttttta ccttcagaac 87960actccctttt gccataagaa cttttagcac atagagtgac cacatagtct tgttttcctt 88020ccacaacagt atctaaatat aaaagaggac tgcaatgcca tggctttctg tgctaaaatg 88080aggagctcca agaagactga ggtgaacctg gaggcccctg agccaggggt ggaagtgatc 88140ttctatctgt cggacaggga gcccctccgg ctgggcagtg gagagtacac agcagaggaa 88200ctgtgcatca gggctgcaca ggcatgccgt gagtactggc agctgcccag ggctgggggt 88260ttcaccaaca cactagttca gaagatctgg gggtctctgc cccttgtagc gctgctgggc 88320agaaagagtt gtggactctg gagtcaggtt cctccctgcc tctgccactg ccacttgcac 88380gtgaccttag gccagtgatt ctaattctga gggtttcgct tttcactttc ttcatctgca 88440gagtggcttc tttctgctcc gtcactaatg aactataaga taccagggga tgacgcttga 88500cttctgtgga tccaggctca gttctcattt ccccacatct gtacaattgg aataatatca 88560gcactagatg aggtgctacg taaaacacct gggactaagt ccctgctcag caagtagcgt 88620atctcaatat cttaataatt attcgaaact tctcctaaaa agtttgaccc ctccttctgc 88680tgccgtgact gccctcccat gcatggtgct gagttgaagt gagaagctga gtgttgcttt 88740gtggcttagt caagttccca agttgtgaaa aggacgaggc tctcaacaac acaagctttt 88800ttttctcctt tcaagtgaga gttgtcttaa agttagcctg ttgccctcag aaggtgggaa 88860accaaagtcc ctttcatcct ttgaacttga ggacattggc agtttttgct tgcctgattt 88920taaatgacaa gttaaatcat agaaattaag ttaaatcaca gatctaatcc acttggattg 88980tgatgatggt tgtacaactg agtaaataca ctagaatctg ttgaattgta cacttaaaaa 89040ttggtgaatt ttataatatg taaattatat ctcaaagctg ttttaaaaag gttctatcaa 89100ctcgttttat gatgatgaag tagccattta tgatgccgta cagcctgatc cctactttac 89160ttatcccacc tttaaccctc agaacaactc tgaggggata ggttggttat tttaagaatt 89220gcttatcttg ttagtagtac agcttgttta gaaaacctac cttctttctg atatttgtct 89280ttctgcctaa aatcttcaca caccagagtt tcaggaaaag gggagaggct tatggtatgg 89340ggaagagcgt agtaggctct tactgactaa acctgacaca gaataaaatg ggctgaggtg 89400tatagattat tagtgggaaa aatccagtaa tattgtcaag ttattttgac taggccgcaa 89460tgtgtacaaa taaccatctt tagacagcag ctttaagtgt gtttgtaatt atcagaacac 89520ctagatgtaa atcagtggtt ctaaagtttt ttttaaggct ttgttttttt gttttctccc 89580tttccccttg agatttggtt tatattgttt attctcttcg ccaagcttct tgccatcagc 89640acagcaggta taaacctcac tcagtttgta agcaaaggtc attgttgcag agtcattggg 89700ctgctgttaa tgagggacca aggagctgct gggaaagaga tgagaggaga gagcctgtga 89760gtctgaggat ggacacagtc gctggacctc ctataactct gggcttaggg tcagccagtt 89820tggggtgtcg gtttctagcc taccttatag aaaatgagtg gtgtctcttc tgtaactggc 89880tcaacagaat attgcagaaa ctcatcaatt tcagaaatac atactgaatg ccacaggttc 89940ttgtagctct cactgttact acagaaagtg atgtttgagg gcagtattgt tttctttcct 90000gtttttcacc tctgtggggt aaagttttgt ttagttctca ttgattcacc ccctcagtag 90060ctgtgtcttg gtttgattct cagctctgca ttttactaga tgagtaacct tgaatcatac 90120taaatctcag gagaccacag attctttgtc tgcaagatgg tcaaaatagt atttacctca 90180ttagatatta ggaggattaa agggtaatac ttttttttaa atttaaaatt ttaatatttt 90240ttagagatgg ggtcttgctc tgtcccctag actggagtgc agtggttcca tcatagctca 90300ctataactgt gacctcctgg gctcaaaagg tcctccagtc ttagcctccc aagtaactat 90360gactacaggc atgtgccacc atgcctggct catttttatt atttatggag gtcttgatat 90420gttgcccagg ctggtgtcga actcttgacc tcaagtgatc ctcctgcttt agcctcctga 90480agttttggga ttacaggtgt gagccaccaa actcagccaa aaaattattt atttatttat 90540ttatttgttt gtttgtttgt ttgagacaga gtctttctct gtcacctagg agtgcagtgg 90600catgatcttg gctcactact acctccacct cccaggttca agcgattctc ctgccttagc 90660ctcccgaata gctgggatta caggtgcaca ccaccacgcc tggctgtggg gtttcaccat 90720gttggccagg ctggtcttga actcctgact tcaagcgatc tgcctgcctg ggcctcccac 90780agtgctgaga atattatagg cctgagccac tttgcccggc caagataata aatttagagt 90840ctgtttgcct gatgcctgac acttagccct cagtaaatgt tagtattatt gttttactac 90900tcagtacttt tatataaaga gatatgtctt tgatctttct gtttatgggt agtaatactg 90960ttagaatcag acctgtgtta gaattacaga cagttccatg gttaaaataa gttacacttc 91020agatatgtaa gtgttggtgc acattcaaat gtggatatgc ataaagaaag gctgggtttc 91080cagcccagtc cacaaaagcc actttatgaa tgaaaatcta tagcatattt gaattatttg 91140tcctaataat actgaatcca aaagccattt gcctatgttc ccaaggaaaa cttcccttta 91200cagtttaact ccatattctc ggtttataag aaagactata acttctgaag ggtaactgtt 91260catattgctt gagaagcatg gattgaggtg ttcaggagag cactagatag ctgccaaggt 91320atctgtagct tcttaactca gtgtctgcgt tggagagagt ccccgcctgg gtgtgctggg 91380ccagggaggg ggccctgtca gtgtcagtct cactgcagat gtccgatttg ggaaacaagt 91440gcctattacc tcatattctc ccaggttttt tgtcatttaa gtttacctca tcttagtttg 91500aggcctggct gcttatgaaa atatcagtaa tagctgatta ttggcagtca ttctcccccc 91560aacctgccta tgtttcaggt tcataaaatt ttaatcatgg gcgtagaagt gagtgacttc 91620ataatctccc tggtctttcc catcattctc ttattgacgg aggcaactgg tggagtggag 91680aggcagggga gcactgttgg gccagctttg tgaagccata tatcttcttg ctagttggtt 91740actaaataaa aaatatttgt gataatcata cagagtactt aagaagtata tttattatta 91800atggtaatag attttaatca ctgacaaaaa tcactttggt tattatttat tctaatatgc 91860attttgcata ctactgccag gaatttgttt gcatgtctga tgtataatca cgagcgtgtt 91920agaattgttt aagtgctttc tgtaggaaac agatggaaga tttccccaac tcccagagtg 91980tttccgatta gcaaagtgca catcaggcag gatctgtgaa cctctcagat aggggttttt 92040ttgaagctgg atttgataag gctctgtgac ggatacctgt aatgagaaat atcatcagag 92100ttttattttt aaatgatcta aatttggttt gccaggagct acagtgcata tttctgggga 92160gtcatagttc ttgatgatta tgatcaaaac agcctgaccg aacctggtcg gaagtctgtt 92220tgccctaaga ggatatgagt gacccagatt ctttgtggat gagagagttc cttatctttg 92280catatattgg gtttagaaac agatggccaa atgtatccgc cttgattttc tgatgtgttt 92340ttttactttt cctcaggtat ctctcctctt tgtcacaacc tctttgccct gtatgacgag 92400aacaccaagc tctggtatgc tccaaatcgc accatcaccg ttgatgacaa gatgtccctc 92460cggctccact accggatgag gtatgggaag tactgacctg gtacctgcct ggctccctct 92520gcactgaggg acagtggtca gcctggagcc ctgagtcact taccaagaag tattgtagtc 92580atttttgtaa tttgtaactt ttgtatttgc ttgatgtgag aaaggacttc ttcagtattt 92640ggaatacaat tcaagatgag tttgatcacc ttcctctgcc acattttaga aaagaaatct 92700tgataaggca gaggatattt tgaatagaat tagtgtccta cagcagagtt tttcaaatgg 92760gtaatcatag ttatgaattt aatttagtgg attcacagtt atgaattcaa tttaatttag 92820tgaatttaag aaaaagaaac aggagacgat actatcagca tatatacata acctaagtat 92880attttttaaa cttttgagat atatatatat atatatatat atatatatat atatatatat 92940atacacacta tatatataaa ggtcatgata taaaatattt ttcttactaa aagttgcaac 93000taaaaagctc gagaaacatt gcctgaagtg ttaactagaa attctaggtt ggccttgctc 93060tctgggagtg gatgttttga ctactccttg aggatttttg gctgtggagc tgtaattttt 93120cttctgatgg gcacctgcct tttctcccat attgcagact ttgagaaatg tcacaggtga 93180cacagacagt cagtacttca atagctgcag tctcctgagt ttgtaaacat atttgttcag 93240taactagaat ggaaaatatg ttagttacat acttgctaag cagaagttaa tgtgtgttta 93300gcagtggaga ttataaatag ggtggatcct ttttgaaaag caggttaact tacagaggta 93360ttaaaacagt agataagctc agatgctaat agaatgcagg gatttgctag aaaagccctc 93420tgaaatctcg gagacttcac agtatcatag ctactatttt tgggagaatt tggtggagtt 93480gtcaccatta cacaatgact gggatgtttt tctcagtgga cactgaacca gatctaactt 93540tctttgataa tcatcctagg gctgactttt tcctcttctt tctatgctta accaaagtct 93600cacctggaga ggaaagctgt gtgccgtgga gatttcaggt cccagctgag ccttctggct 93660attggctttg tttttccaca tgtaatcttg ctttttgtgg cctggggatt ggctgtgtga 93720tcagcattga aatgggttgt tgcagtttga agtctggaag gggtatgtcc ctgggttcta 93780attctttccc tctaggtttc tgtactcagc tcagagtcta gaatggtagc ttttaggatt 93840ggaaaagacc aaagttacct aattcaactc tttcattttt ttttcagtgg aaaaactaat 93900acccagaaaa gggaagagag ttaacccaaa aattacatct agtgaattgt ctgattagct 93960ttacaattga ggcattgtag agctctttga ggcattagtc ttggttgtct gagtgcctgg 94020ctattaaagg ctgtctttgc ctgttccctc tttctgttag ctgcctggaa gtgcagggtt 94080gcttcacttt tagcaccttg actctgtacc tgacatggtg cttcaacagg atattgcttt 94140gttaccacag gccctttgaa cttggaaaaa aaaaatacca ccctaagcta aaacatttgc 94200ctgatgacaa actacaaaga ttttgaaacc tcataatctc accactaaag gaggcgtaaa 94260tgaaaataaa tgttggtgat gatttcagtg gagtaccagt tttactttgg gaaatattct 94320tgtatttcaa ttatcgtttt ctgtttttag ataatgcttt tgatagttgt tgggtaatca 94380tagttatcct caggtatctc tcctctttgt cacaacctct ttgccccgta tgatgagaac 94440accaagctct tatatatata tcttagcata agacaaccat attctgtatt ccttttcaaa 94500aaatattttc ttgctttttt aaacaattga atttcacagt ccattaaaac attttataga 94560agcctaaaga gagtttgttg tgtataatat ctgcatataa acttaaaata tgcagttatc 94620tgtacataat tttctcaaaa acttgcagtg cgtagctctg attgatgtct atttgtcttt 94680tttttctttc tcctttcttc ctgctttgtt cctccacgtc attttgaaaa ggaatatagg 94740caggtatcat tctacattta ttgatgtcat ttttaatttt ttttccattg gcatgctata 94800gtatctggaa tttttgtgta ccaggtttga tgagcacctt tataattaat tttaaaaagg 94860tgtgtggaat gtctgtcttc agtgtgtctt caagcttggt cttatgggtg atagggaggg 94920tactgattct ggtagtcatg gatttaaaat tttgttaata tttttgacat cttattaagg 94980agaaagctgc cggccttatt ttaggctccc tcatcttctg tttaccttta gcctttgttc 95040cagtggagaa gctacacatt atgtttggtc tcctcagcct gatgctgtct gagtatctga 95100cctaaaggct tccaagacaa agatggtccc acagggctct cagcagcctg gaagaatatc 95160gttgttcaga ccagattgaa gattgtgttc tgcccagagg gagtttgttg ggccctcatc 95220tctaccagat ccaaggactg tttctcacag agactcagta ggatgtggaa gaagaaggcc 95280gtggctccgt tggctcaggg aacatctgcc ttttcccctc ctgccacctc ccctggcagt 95340ggagggtgac ctgtctctct ccttggcacc tcatcagaga ttcttctctc ttggacaaca 95400ccctccatcc tcggaaccct tttctttcct tatctcggga aaccttccat attgtaccta 95460cttctcattc tcttattact gccttcctcc gccatcaaac agcatttacc cctcctgttg 95520gccattctgt cagaacccct ctttgaacct ctgtagctgg ttcactcctt ccttcctgct 95580tgtcccaggg agaggatcgt ggctaagttc tcctgggcac gtgttctgtt ctacccttga 95640agagcagtgc caggcctggg tacagcatga gtggcagcct ccctgccagc tgatagccct 95700agctttccac tgtcaccagc ggagggtaag ggaacagtcc agcagcttca gaggcctgac 95760gtggctcatg ctgcccgtgg ctctgcagat gtgtgattct ttctgtgtgt gagagagaca 95820ccaaagccca cagtcaaatt ctcagtcact ttcgtaaatt acaaggaaga tgggctgtat 95880agaatcattg aagattataa aaatgttggt ttttaccttt aaagtaactt ctttgtttat 95940cctttccatg ttaattgcta ctccctgagt ttattcatct tttgtttatc tatcaagcat 96000gtgttcagta gctgttaggt accaggcact gggattcagt ggtgagcagg acagctgcag 96060cctttgcttc cgtgcacagc tcacggcatt gctcgaatga tgccacaggc atctgcttct 96120ctctgccgct tccgtttcta tcttccatgg ggcttccctc ccaggagagc gtgcctcata 96180tgtgcctggc tttcgttctt tgctctgcct gctttgcatg gtccaggctc tgtagcctgg 96240catttaatta ttctgttcca gcttcccttc cttggtgctt tttcccctcc tgccacctcc 96300cctggcaatg gagggcgacc tgtctcctcg gcacctcgcc agagactgtc atatgtccaa 96360ggacaactta tcctttaagc acagtgccta gagcacacac ttgttagggg cccataaaat 96420gtctaatttc acttaaaatc agaaaacata gttgagaaat ataacttgta atatttttta 96480tggaggaagg gaaaagtgtt tagggcctat ggaagtcaca gtgtagtcct gcttgtgata 96540cgtgccccat tgtgtgttgc tggatagttg ctgctggacc tgaccggttg ctcccagaga 96600caggaactca cagagtacga gaaacatgcc tgagagccct ccacatctca ggccctaact 96660cagggcctgg cttgtcttag gctctgcaaa catagcacag tgacagttgt tgaagtgtag 96720cagcagcttt ttgcagggaa agagggagtt gtatttattg cttctccatg acatggttct 96780tttctcatta gttcatgggc aagtcaaggg aaagagacct aggtagcagc tgagtctgta 96840gcctacagat ggcctgggct ggcttggctc agtcacttcc cttagtcact tccacacatt 96900ccagaaattg tgtttttctt acaggtgaca gaggaagtta tatatggaag gtagggttag 96960gggcaccaac cccctgtgca attgacaatc catgcataac tttgaccctc caaaacatag 97020ctaataataa tagcccactg ttgactggaa gccttaccaa taacataaac agactagtaa 97080cctgtatata tcttatgtat tcatgatgta cctttttctg aaattaaaaa aaaaaaattt 97140ctgtgctaca cagttcgtca gttttttcaa actgttgcaa atctccaaaa aaattttcaa 97200tatacttatt gaaaaaaaaa tctgtgtatg aatggacttc tgtggttcaa acccatgctg 97260ttcaaggggc aactgtagta gttaagagaa caggcttttg tagttttagg tcacctagcc 97320tcttggaatc tcagttttcc tcatctgtaa aatgaatgaa accttccttg tagagttgct 97380gtgaagatta aataacataa tatatataaa gtgcttgtta actcgtttca tgatgcctgt 97440agtggtgttt gggtagctct cttttaaaat cctattcatc atgtaagata caccatcagt 97500tgaatagcag caatctggga agtaggaaac actgccacgt aagctgtata tcttgattgc 97560gtgatgaaac taagttgcag gaatgttaaa atgtcaatca aattggtctt ggattcgagg 97620tagaatgggc ttagcagtgt ggctgatggt aagcgtgcag ggagctgtgg tcagcatgga 97680gttccagtca gcaggtgttt ccctattctg gaagcatagt gagaagtcag aggagctgtc 97740tttgtgatct tcgggaagtc actttagctc cctgagtcat agaggaggtg ctgatgggac 97800acttctcacg cagcgctagt aagaaggaaa gagatggtga ggggctacaa ggggcagggt 97860tgtctgcctg cttctcaggg cacttcagcc tccggcactg accactgttg gtgagccagg 97920acgccctgcc cacatctggg tcccctttgc cacaattggc attcattttc ctgccttcca 97980ggttctattt caccaattgg catggaacca acgacaatga gcagtcagtg tggcgtcatt 98040ctccaaagaa gcagaaaaat ggctacgaga aaaaaaagat tccagatgca acccctctcc 98100ttgatgccag ctcactggag tatctgtttg ctcaggtagg aagtttgggc ccaggagaag 98160ctggagtttg tgggatggga gaggcattgt agagctcaga ccccctgctg cagctgaact 98220tggtggtgct agagtgcttt aaggcctgtt ctgggtaagt tcttgccaca cctggacttg 98280ccccaagtga ggagaaaaaa ggcagcattt cagctttcca agaggctggt tatccagctt 98340gtgggctttg gggcttcctt tctttcctat tcctttcctt ttccccacct cctaccattt 98400tatttttcat ccgtattaat agccttatgt gcagaggtca gagggaagct ctgcttgtta 98460gaagatgtaa ttcaacaggg ctgaagaagg cacttctcag cagccgtagt aatgtctggg 98520gaggaaggag atggccactc tgtcactggt ggtaggatag aaagattaga cgctagaaaa 98580aaaacaaaag agaaggtaga atcacctgaa attacattta ctctgagatt gctaagattt 98640ttagtagtat gcttcctgat tttaacatgc aaatttagat actgtataga ttttgaaaat 98700attttatggt tcattttgtt ttgtaaactg cttttttatt catctgattt tttttattgt 98760ttgtccttca aatgtcaatt aaaatattga tcttcgttgt tttaatgact ttgtaacaat 98820tcatttattc aacaaatatt gactggatgt ctgcgtacta tttgcctcag gcacttgtac 98880ctgctaagat gctggagatg ctggagtgaa caagacagac atggcctctg catgcatcag 98940atgtacatca agttagaaaa caagcaaata aaatgataca tagataatac gtaagaaatt 99000atggaaagta ctgtgaaagc agaagcttgc aatagagaat atggacaggg gggtttgaat 99060gggaagacct aatttaaatc atatgatcag agaaggtctc tctaaggagg taacatttat 99120aatgaatcct gaagaataaa aaggaatctg caattctaag agaggggtgg gggactattt 99180cttccatgta gagtgtctca gcagcagcac tactgacctt ttggcccaga tgattctttg

99240ctgtgatggc ctgccctatg cattgtaggg tatttaccag catccctgcc tccacccagt 99300agatgccagt agcactctct ccttagcagt gatgaccaaa aatgtcttca atattgccga 99360ctctcctctc agcctcagtt gaaaagatct gatgtagagg gaacagaatg ggggaaggcc 99420ctgagggcca gtagagctgc aaggagagac catgtggctg cagaccagag gagggtgatg 99480gggaacgagg ctggagaggc aggtgggggc agattgcata cacagagcct tgtaggagct 99540ggcaaggggt tatgctttaa ccctgagtgt ggtgggaagc catttggaag gcttcatttt 99600atgtatgttt caagtcgatg attcttgtta cacgtggaaa gcagattgtg ctgggtccaa 99660gagtacactc gaaacataca agctgagagt ctgcagcaat gatcctggga gagaaaatgc 99720tggtttggcc tagtgtagca acagtggcag tggagcaaaa tgagtagatc tgctgttcat 99780cttgaagata gaattgatag gatttgctgt tgagttggat gtggaagctg agagaatttg 99840aggaatcaaa gatgatgact gggtttctgt tttgggtgat gtcggatgga taatggagtc 99900attccccaca cagggaaggt cttgggggaa gagggtgggg aaggggcaga aatcaggagt 99960cctttttcgg agatgcctgt gaaacataca agtggagatt tcaagtagga aattgagtaa 100020tgaggctgga gtccagagga aaagccgtca tttatttaac ttagtcaccc gttcctggac 100080attttctgtt tttctcgttt tcccttttat gctattactt tatagtctgt tgtgaacaac 100140tgcatacgta ggtggtcctg tacacgttct gtttattatt accttagagt ataccattat 100200gtgtgagatc acacacgtat cagtatatct gtgtcagagt tatgtcccac tgtagggctt 100260tagttactaa ttgtccatta tctccattcc atctatgcct tagaactgcc atagagacaa 100320cagagaaagg ggacagtgca cagccccagg cagatactgt gtggaaaaaa agaaaatgaa 100380ctggccattt ttagatggtc tttttggatt cagcttccca gttttgtgta tccatagctg 100440agatttattc tttacctttc ccgggagcag aggtgtaaag gaagagtgtg ccatacttga 100500agaataagca tggcgttaga ttgacctttt ggaggctcag gaataagtga cttgaggtag 100560ctgtacagtg aatgtttaca aaaaaaccac aggccaacag gacagtttca ggttttcctt 100620tgctcttcac acattactgg catagatcat tgttcctcag aagtttttgg aatgtcagtg 100680acctttcctc acctgagaga aacaagatat cccatggtga aaagaagaga aacgggagca 100740gtgggagccc tccatccaaa aaccattaat ctgaagttct tcagggaaag agagcatctc 100800acatatgcag gaacacttct cccaggcttt gtgcctgccc tgctccaagc tggagaaagg 100860cttaagagtt cacactttag tgttctatgt actttaagtc atttgatgaa aaccgaatgt 100920ggctgtagca cggcattgaa cagtggtcct ggccaggtct agatttaatc ccagcctacc 100980acttgctaag ccctgggccc ccagggtact caattcttct acttgacttg gggttttata 101040actgcctgac gttagatact cctagtcatt tattcttttc tttctcctta gagtggaatc 101100tccaggagat caggaacgtg gtttagttta ttgctgtttc cctagcacct agaataacat 101160ctagcccata attagttctc aataattacc aaatgaagga gtgactgaat aggggctgtt 101220tactgttttg tgccttagat tcctcatctg ttggagatga cgatgttaac atccacgttg 101280taaggtgtta tgaggactaa ataaaggagc caagcactgt gtggcagcac tgaggcaggg 101340tttaatcagt gggagccggc actggaatta tcgttttcac tctgtacaaa gctgggctgg 101400gcactgctgg ttagccttgt tttagttttt gtgtttaaag ttcccgttag ttcttagaat 101460gctgtgcacc tccatcagtg ggggggtata ttttggtgac acatttcact atgggaaact 101520cgaacggtag atgtgggaaa atgtacatgt ggtgatgatg cactgcggaa cgttcccctt 101580tccctagagc tacaccagaa tggagggaga gccccatcaa ctctgtacac ccagctccta 101640gacaaggcca tctaagcatg tttgtggaat tcatgcatga tcagacctca gcccagtgtc 101700accttccctt gctctggcgc agtccaggcc tagtacacag tgtttgtcag cgtcacttct 101760atggcgaagg gacttcgtat gtctgtactg ttccccagtg cctggcatag tgctcagtca 101820atgttttgtt aaatgaatga gcgggggaga acatctcctg agccccttca cacccaactc 101880tgtttaaaag agctctgatg ctagagaaac tgccaatctg attcgtctcg ttgctgtgct 101940gcgtttctag gcggcccctc cctgtgtagt agccttcttg tcaagatcaa aaacgggtgg 102000gctctcatgg tttctccccc ttgctcctag ggacagtatg atttggtgaa atgcctggct 102060cctattcgag accccaagac cgagcaggat ggacatgata ttgagaacga gtgtctaggg 102120atggctgtcc tggccatctc acactatgcc atgatgaaga agatgcagtt gccagaactg 102180cccaaggaca tcaggtaaag cttcccactg gctgaagaat tgattgtgag gatggtggtg 102240tttctacatg ttcttacaca tttcagctta attactgcca gggtttggct gacctttgct 102300ctctatgaaa cccagatctt ccttagaatg tttactacat acacgtagcc taattataat 102360tgtgtcttga ttttggatgt tggctgctaa tctcagaaat ttgtgcttgg gtgaaatttc 102420tgagctgagg atgccaataa aattagtggc ccccaggcct tctccgtccc ctccttgccc 102480atggtggaca ctgtcgtcta tcactgcatt ttttcctttt gttttggacc catcttaaaa 102540atccttctca gtacagttct gtaagcagct actaccatcc caagcctgaa ctctgaacac 102600gttacagtag ttcactacag agctgttaat tctaatgtga gaattgatca actactatta 102660aatatctcaa gaaaattgca tttacttaaa aatatcgttt gagatcaagt ctctgtgaag 102720gaatatttaa gttctgtcca tctatgacat ccaatagttt tttttcacca gtgggctatt 102780aggatggtca taaatgaaga cagtctcatt ttgaagaagg gatttcgtag ctgcattgtt 102840tgtgataggc ggcgtgcgtc ttctcattag gttgctgctt gtttctcctt gcgcttgacc 102900agagtctaga gcagatcaca gcttgctcct cagtgatgca gggattgagt cgatactgct 102960caactgctgc tttctctttt ttctgtggcc ttcactttgg gtacttcctc tttatttttt 103020cataagctaa attgaaaaat gacagttctt ctctaattct gttatattac attaatctaa 103080aagaaaaata acatttgttg aggatgaatc ccaaacttca caattttcta ctgttctgaa 103140gccactccat gcggcaggga tgacccgggg ccaggtgctg tctcagtcct gggagtaaca 103200agcagatcag tctccgcatt tggcccccag tggacttgtt ctttgtttca ggggtactca 103260acgttcttct taacattgac tcccgttcta gcagtatatc agcttgttta gattctgttt 103320gttgtagata ctcgcccact agcacctgga taggtaacta atctttcagc ttacctgttg 103380atcttttaaa taatatatct gattcatatt cacatggcaa acactaagtc ttttgtatta 103440attagcttta gtatgtcttt ctctctctct ctctcactct ctctctctct ctcttttttg 103500tgggggtgct tggggggacg gagttttgct gttgttgccc aggctgaagt acaatggcat 103560gatcttggct caccgcaact ttggcctccc aggttcaagc gattctcctg cctcagcctc 103620ctgagtagct gggattacag gcatgtgcca ccatacctgg ctacttttat atttttagta 103680cagatggggt ttctccatgt tggtcaagct ggtctctcac tcccgacctc agatgatccg 103740cccgcctcgg cctcccaaag tgctgggatt acaggcgtga gccaccgccc ccagcctttc 103800tttctcattt ttaaaataaa aaatgtgatc tgtttagaaa agttataaat cagacatgca 103860aatagaacat acaaagcatt tctcatcaca caaaatgaca attgctccta acaccttgca 103920gaccattttc taactgatgc tcaatcctag taacagtgtg tagatgtgag tactaatgtg 103980cacaagaatg gtgaagctag caagcaaaaa tgtagatgcc ctgccttggt gacccagaaa 104040attgggcaat acttgtagca attcccattt cagtgaaatc tgtggagcat gtgctttgct 104100tttctttccc agtttctatt cacctgcatc tccttatgat ggtcatcttc agtgctaact 104160ccatctaacg tcctctggga atagatctcc ctttcccatt tggcaacatg tggattcatg 104220gacttagatt tgtttctaaa ctattttctc ctaacctgta catgaaaagg agatgtactt 104280ttctactgtc ttttagctac aagcgatata ttccagaaac attgaataag tccatcagac 104340agaggaacct tctcaccagg atgcggataa ataatgtttt caaggatttc ctaaaggaat 104400ttaacaacaa gaccatttgt gacagcagcg tgtccacgca tgacctgaag gtgaaatact 104460tggctacctt ggaaactttg acaaaacatt acggtgctga aatatttgag acttccatgt 104520tactgatttc atcagaaaat gagatgaatt ggtttcattc gaatgacggt ggaaacgttc 104580tctactacga agtgatggtg actgggaatc ttggaatcca gtggaggcat aaaccaaatg 104640taagtggctg ttggcagtcg atcaaagaga acattcccgt gtcacatagc gtatgctgtt 104700tatccttctg gagtcatctg tctgcatgtc catcactccc ataggctgag tttatttagg 104760agaccatgta tcattcatat tttatttcat ccctgtagca caaggtctaa ataagtattt 104820attgagttat gtagagaaat ataacaacat gtataatacg tagtagtata ataataatag 104880cagatagttc ctgagtgttt accatgtgcc aagtactttt ctaagtattt tataagtatt 104940aactcattta tttctaaaaa taaaaaaacc tttgagggaa gtattgctat tatctccatt 105000ttacggatga atacaaagag gcacagagaa gttaagaaat ttgcccaagg tcataactaa 105060taagcatttg tgccaagaat tgaacttagg cctctggctc cgtgaaattg actaattgat 105120tttgctttat gggagcttct ttatgagata tttattggat gaagaaatag agcagagtgg 105180cttaagagca tgggttttag acccacgtcg acggggttca gatcctagct tcatgactta 105240tatggcctta ggagagttat ttcaccttta tcagcagcta aaaattactc ctctgttaaa 105300tggaggtacc tactgtctaa ctcataaggt tgtgaagaaa ctaaacggca tttagcacaa 105360agcctggcaa tacaataaat gttgaataaa ttattatagc cgttacaatt attattactg 105420taattaataa tattaaagta aatgtgggtg ggtgcagtgg ctcacacctg taaccccagc 105480actttgggag gctgaggcag gcagatcact tgagccgagg agtttgagcc tagcctgggc 105540aacatggtga aaccctatct ttacaaaata taccaaaatt agcaggatgt ggtggcacgt 105600gcctgtggtc ctagctactt gggaggctga gttgggagga tcgcctgagc ctgggaggtc 105660aaggctacag tgagccatga ccttgccact gtgctccagc ctgggtgaca gcaagacact 105720gtctcaaaaa attaaataaa tgaataaaat atgagactca ttttctcctc ctgttttatt 105780ctcatgctaa aacaataatg cttgatactt actgagggtt ttctgtataa taggtattat 105840actatgttag ttagcacttg tctaatctca gagaaccctg tgaagatgta agctatttca 105900tgaataagga aaatgaggct caaagagatg atgtaactag ttaagtaatt ggcagaggca 105960ggaacttaac ctagatctct ggtctccagg gctcatgcga cacaaaatat tttcacttgt 106020gcagatatat attattcagt gtgtagatta tttcaagcat gaaattcgtg tcttctctgg 106080aaaatcccga cttgagtact gttacaaagt caagacgatt ggtgatagga gaaagctcat 106140gttcagctca gtggtaactg ggaagagtat gttatctgtt tgtgtcagag catgtgtagt 106200agtctggaag tgaggagacc tgaatgtaga tgcatgtcta gtgagcagtg atttcccttt 106260ctgagtttcc gtgcacattg cgtattatat agtttagaca gtgtgctcat taaggtctct 106320tccagatatg aaagcccagg attccctgat acaacccagt tctttggtcc taaccctgca 106380ggtgccaact cccccaatcc tgcaagtcca gaagagctgg ctttctcttc cttggaccta 106440ggccctgcat aggtttccca gcagcactga ccttttacca atagaaaatg aagaaagcaa 106500cttaaccctg tcccttttat gtatcttatc aggttgtttc tgttgaaaag gaaaaaaata 106560aactgaagcg gaaaaaactg gaaaataaac acaagaagga tgaggagaaa aacaagatcc 106620gggaagagtg gaacaatttt tcttacttcc ctgaaatcac tcacattgta ataaaggagt 106680ctgtggtcag cattaacaag caggacaaca agaaaatggt aagtttgtcc cagaagctct 106740taagtctgga tctggtgatg agagggagaa ttgctgagtt ccgttctgca gcacatgatt 106800ttcagagttc ctgtcctaaa gagaaaacag gattttctta ttgaagccaa aaagttccta 106860ttaccaaggc attctcagtg ttttaaagtt acaccgatac attccagtgc ctttctttgg 106920tctcagaaat gtgaatctgc cttaggattt gcttccctcc caaatacacc tcagcatcaa 106980tatttaattc acaaagctag tggatttgaa ggaaaagaaa accagcgaat gtcagtgttt 107040cctcccaagg gttctggcac ggcctctctg ctgagctgaa gtgcaaagca ggaagcccca 107100cgttgccctc aggcgagcct cggccacagt ggcagtcatc gatatggtgt caggcacacc 107160ccagtgactc tcggacagag gaaagggtgt ttaatctcac ttcctctttt ttggtatcac 107220ttgaggacat aatctaaaca agcaggaagt gggaactctg ccaaaataaa cctgtttgtg 107280tcaggggaag tcacagccaa caacatgcag agagagcggc tggtgagaca gctagcactc 107340ttaaggtgag tggagccaac accaggaaag gccacattct gccaaaatgt ggcagatact 107400gtgtcacaat gataacgctc agtgctgagg aagagcctgg tgatacggtt tagggcagac 107460agtcactctc ttgtattcag aataacttgt ctttctgata taaccttttg gaaaacagtt 107520tggtaacctg ttaaaagcct tgaaaatatt tatatatccc tctgttcagg aatctagaga 107580atgaatctat cttccagaaa caatgtgaga ggcaggttat ggtttatgaa taagaatatt 107640cattccagta gtaattaaag tgtcaaaatt ctgaaaataa cttaaatata caataatagg 107700agaataggaa aataaatcac aatttgcctg agaagcagaa tattagaaaa tcaggttgct 107760gaatttttta atgacctgga aaaaaggtca ggggaaaaag caggatataa aactttacct 107820atagaatggg accagttttg ttcaaaatat caataggtat gcatgtatat acacatgctc 107880ttagaaaaat aaatattaac agctacttat ttatggtggc attatgagtg gttttaattt 107940tcttattctc ccctcctttt tttttaaaca aaaaacttac attaatttta ttagaaaaat 108000atagtaaaaa caaagtgaag agggagaagt agaagagctc agatggatgt taatggaaag 108060atgcgaaatg gagggagaaa agaagaagtg ctgttgatgg agcacatcct ggatatcagg 108120ccccgtgtta tatgctgcat cctggatatt aggccccgtg tcatatgctg catcctggat 108180attaggcccc gtgtcatatg ctgcatcctg gatattaggc cccgtgtcat atgctgcatc 108240ctggatttta ggccccgtgt catatgctgc atcctggata ttaggccccc tgtcatatgc 108300tgcatcctgg atattaggcc ccgtgtcata tgctgcatcc tggatattag gccccgtgtt 108360atatgctgca tcctgggtat taggccccgt gttatatgct gcatcgtggg tattaggccc 108420tgtgttatat gctgcatcct gggtattagg ccccctgtta tatgctgcat cctggatatt 108480aggccccgtg tcacatgctg catcctggat attaggcccc gtgttatatg ctgtgcctgt 108540atcttggtct gtcttagtcc ttgtaagaac cttaggggac tgagcatcag ctctacttga 108600aatgaggaat ctgagactaa tcaagaggca tgggatcttg cacagggtca ctcagtgaga 108660aagtggcagg cacttgccca gctctgtctg gttcctgcct gtgcattttg cctgtgttgc 108720tttggcttct aaggcgttat catcccccag agaccccgaa gggagtgagg gagaggctga 108780catgtccatg atctggctct tcaacgtggt gtatgcctgg tgcacatttt atgagcctgc 108840cccatcctgt cctgtcctgg ttgacacagt caagtctagc accaacacaa gttggtgcac 108900ccatcatcta agtcagagct caccctggcc acatgggcca atgactctat gccaagccac 108960agtgctgtgg agggagcagg aggagggcag gaagaaagaa atacttgatt cctccattag 109020tttgtttttc tttaccacgc tagcccttac tgtgtgtcag gtacttccta ttctgagcac 109080ttcacaaata ccacctattt taattttcat gtcaacccta tgggtgagta tgataagggg 109140aaactgaggc acgaagaggt taagtaacct gtccaaggtc acagagctgt taggttaaag 109200catttgaaat tgccaatatt tgaccatttt gacctataaa aatgatgatt ccatatgcat 109260aaccctacta gcaggtggag aggctgcgat ttgaacccag agcagctggc tctagagcct 109320gagctgaggg ttgaccactg ctccatgctg ccagtttaga atctcatgcc ctcgttgtcc 109380cctcccagcc atgggattcc caagcccttt aatcaggcag tgctttgaag aaaccctgat 109440accagcatgt tgtcaagtca gaccttcatg tatcacttct ctctacatct ccttggcatc 109500cctcatttct gtttagactc ctgttctcag gaaatgtaag tgcagatgtg gtcttactta 109560tcatgtggct gggtgagggg ctgcccaggc cagcctgccc cttgttcaga gcatcttgaa 109620tttgctcttc agggatatcc gcaggtgggt gcctggtcac acccgcaagg cagtgtgctc 109680agtgtggttt cttttttctg aagtgccatt cctatggtga ccctgccctc tccaggcctc 109740cttcctcata gccccaggca tgcttccttc ggcattacag ctgcactagg cccctgacct 109800ccctcctgcc gagtggcttg tctcccctgc tcctttttcc cttcactgtc ctctcatttc 109860tgccacctgc ctctcctttc tacagggcta tgaaagagtc attttgccct tttttgaagc 109920ctcagatgct ttttaatgtt tttttgtgag tcaaagctcc aaatcatggc ttttgcatac 109980cttcccttgc caggaaatgt tcttgattga cctgatagtt cctgtcaaat gggcagtctc 110040ttcagggatc aatgatcagg acaaaagtac cccaaatcta caacacaggt gtctttcaga 110100acaccttcct tgatggaaat cccctccctc ctcttctcca caggtgcctt tgcctcttcc 110160cactctgagt aagacactct gctctctcca actctcagag ctccctaggc ttaatctagc 110220aaactcttca ctgggcctgg gattattcct agattaaaat ccgggagttt caccttctag 110280agcaagtctg ctatgagatg aaccacactg cctctgtttc ttttctccta agcaggaata 110340atgccgattt agccattcac cgttgagtgc caagatcacg gtgcatgctt tgccccttcc 110400cacctccact tttgtgcctc tgccaccttg attcaggctt cctcttctcc catctggacc 110460caggggacag cttctctgca tgtctccctg cctgccacag cctcccccac cgcgtcaccc 110520ccaacacaca cacacataca cacacacaca cacacacaca cacacacaca cacacggacc 110580caggggacag cttctctgca tgtctccctg cctgccacag cctcccccac cgcgtcaccc 110640ccaacacaca cacacacaca cacacacaca cacacacaga gtcatctgat agtttgagat 110700aatagatggg aaaatgtgtt gaacagtgaa agtcctatat aaatgcaagg gggatcgggc 110760acagtggctc acggctgtaa tcccagcact ttgggaggcc aaggtgggag atcactcgag 110820gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccgtatctac taaaaataca 110880aaaattagcc aggtgtgatg gcaggtgcct gtaatcccag ctacttggga ggctgaggca 110940gaagaatcgc ttggacccag gaggcggagg ttgcagtgag ccgagatctc accactgcac 111000tccagcctgg gcgacagagt gaaactccat ctcaaataaa taaataaata aataaataaa 111060taaataaata aataaataaa taaatgcatg caaggggtat atttagtatt gatgaaaagg 111120ttttcccttt ggggttccca ttgggttata aaaatcttct cactgtgcac ctccctacag 111180agtcagccac ttaagctgat agagacatga tgtaaccgtg ggaatttctt ctctctcaac 111240aggaactgaa gctctcttcc cacgaggagg ccttgtcctt tgtgtccctg gtagatggct 111300acttccggct cacagcagat gcccatcatt acctctgcac cgacgtggcc cccccgttga 111360tcgtccacaa catacagaat ggctgtcatg gtccaatctg gttggtccta gaaccttatc 111420agttgccttt ggtgtgcaga gagcccgtgt tttagtgatg gggcatgtca tcattgttta 111480ggtcaggcca gttgaccatg ctgcctggta cttgttggct gtcctccttt cctccctgct 111540gtccaagctc tggtcaggcc ttcctgtaat ctcctaccat cctctttgca gcagcccctc 111600aatgctgctt ctttacttgg atctctcttc atagtttaac cccctcacct ctccatagct 111660gatcaagaag tactacactt tctgatttct tgctgtgtca aacaatgtgg gcaattcaag 111720aaacactgaa cacagctgag cgtgctgcca tgtgcctgta gtttcagctc cttgagaggc 111780tgaggtggga ggatcacttg agcccaggag ttcaattcta gcctgggcaa catagcaata 111840tcccatctct aaaatatata aaagaagaaa aagaaagatc agatgatgat ctcagcatca 111900gacagtgtaa taaatggaat tgtcagtcag cttgtcccaa ggtgccaggt gaacagtggg 111960gaccgtgagg gtaatacagc cttaaggcca gaaggggctg tgtgggatgc cttgtcccac 112020ctgcatctca gaactggcag cctgtgctga agtacctctg gtgatgggca atgtgtgagg 112080cagcccatgg attggagctc tgactgtgag agatgtgcat acctttctga tatggagctg 112140tagttggctt ctctgtaact tctgcctact cacttgaatt ctgccttttg agacaacagg 112200gattcttttg actttctctt acatatgaca gcccttcagg caaaggaaaa cagccagctg 112260ctgtgtttct tctgagcctc tcttttcaga ccacagaata tctggggaag catctcttct 112320gccacctttc acatgatgtg cttctcacct tcttccctct tccggctgcc ttgtggacag 112380gtagcttagt agtcacatgg ccctggcctt gagaggctca cagactcata gggaaacaga 112440cacacaaaga atggcagagc aaggggttga gcatttgaaa agcgtcttct gccaatgtcc 112500cagccatggt tgtgcttcag ggcccaggca ctcgctcttc ccttggccca gaatgccctt 112560cctccagaat ctgcacagcc tccacttcct tcaggtgcta gtcagatatc accttatccg 112620tgaagtcttc cttgaccacc ttatatacaa tcatacctct ttcccttctc catcccatac 112680atgttggcca ctgcactcta ccttattttc cttcagtggc agttgttacc tcctgagata 112740ctatgtttat ttacataaca taacatttgt tcctggtctg actaccctca cctcccagaa 112800tatgagcttc ccaaaggctg gggctgcatt gctcactgct ttcttagcac acacagggtc 112860tgacacattg taggccctca gtgagtattt gttgaatgaa tggatatttc atgtttgatg 112920ggatgctgac attccttgcc taaagagcct gctcagagta ggtggcattc aaatctgatt 112980aaaccaaaga atcaatgatg gcttgccagg ccttaaagca cggaaagggt acctagatga 113040gaggtcagca catgcaaagg catggcgcag ttagaaagta cacaatgtcc ctgtctctct 113100aaaacacacg aaccatggcg gccctctctc accagcactt agcaagcagc actcacctca 113160tgcagggatg tattcagtca gtattcactg ctctctacat gccaggactc actggtcctg 113220gggatacaaa gaaatgtaag acaggcctgt tcctactaac atctgtccag tcctcactga 113280tgtattctct cagtgtgagc ccatggtgat acaacaataa acaacatggc ctccagttcc 113340cacccccatg aggtttgtgc ttccactggg ctggctaggg gtggagggga ggcgtggcag 113400atgctcatca ccagcctcca gagaggctct tctgtcttga gctggagatg atgtctgtag 113460ggaatgcggg gacaagcagg gctcattgcc ttgggcagga gtctgagtcc tcttctcaac 113520cttggagact ccatcggtcc tgaggccact cggtatttcc gctacgctca tggatggcat 113580cagaggggac tttaggatcc caggcagggc agatagtgtg atggggctgt taagacttga 113640ggcagctcag gagagtggat agcccagagg ttcaaagtcc tgtttggtgt gagctctttc 113700tccctttgcc tacttctccc tctagtacag aatacgccat caataaattg cggcaagaag 113760gaagcgagga ggggatgtac gtgctgaggt ggagctgcac cgactttgac aacatcctca 113820tgaccgtcac ctgctttgag aagtctgagg tcagtcagga cactggcttg gaccaggcca 113880tacagccatg aggtgtccag tgtagcctgg ttcaggagct gctgcagaca gaaccaccct 113940tggcagggtg gaactgaaaa gcctgggtct ctgagaagat ccctgggagg tcaggcaagg 114000gcccctgctc tcaaaaggag actgctcccc agtagccaga cccctgcatc ctccccctgt 114060agggcccttc ttccttcatg ggacccatgg tgggggtcca ccatggctct ggaagacaga 114120acatgaccag aaaaccaatt cacacccaac acttggaaag tatagtgtca ttatttagag 114180tggtttattt agactcagtg ccaccatcat ctcagaccca gagctatgcc tgtctacagc 114240attcactggt acaaaccagc gcccaaatgc cacttcatcc acatggccta acacagtttt

114300ttccaaatgg tagcttcaga cactttaaca aattgccacc ccatcttaga acaatgaata 114360gagatgtctt ttagtgattg aagcgtagct gaagctgggg atgatgtgag atacattctg 114420agggctaaga tattcaccag aattactgac tttgcctcac tagaccacaa atgcctttgt 114480tattcatgta attaaaaaaa ctacaaagtg gaatattttc aaagacagtg agttttacaa 114540aacactttac atcagtacac tttaatcagt actggttagg ctccacatgc atggggagac 114600ctgggacacg gaggggcctt tggcacggag ggtagacgca ggaaggacag cttattggcg 114660aacccctggg gctggactca gtcaagagtg ggaggaggaa acggcagaag gaaccagcgc 114720tgccaagtgt cctgggtgat gcaatgcagg aacaccacca cctgcccagg ctcttgctga 114780acagctgggc ctcggggctc cgtggctcag agcctgtcag gttcattgcc ttcccagaat 114840gcttgccgtc tattcatcag tcattggagg aagtttaatg tgtttacgat ggaggggtgc 114900atgagacagc ccagcctcct cctgaagtgg aattggcctg tgcagtacca agagtgtccg 114960tgactcccta acaatgtcac atcacccggg gaaaacagca gtcatagaaa tgattacttc 115020caccgcacac tgtggcccac cagaccctgt gccaagcgtt gtacctactt gtgctttttt 115080aagccttgta atagccatat taggtaggtg atattatccc attgtacaga tgaagtaact 115140gagattttga atatcatctc ctagtttaca gcttatgtaa gtctttctgg ccctcattgt 115200ttaccactaa aatagtttag tttgtacaaa aagagcccat gagggaaaac tgcttatacc 115260tcctatctgg caccacagtg tcccaaacct gggtcagaca ctgaacacca gctcccagtg 115320tggttttcct caagtggaga catggcctgg aagggctcag tttgaggctg ttccttgaga 115380agttgtgcca tcataattat tacctcatat ataatatctg ctggacttta taaagggctt 115440actaagtttt tcaatacacc atgttagata attgtagcaa caatcctatg aggttggatt 115500ttcatgaact ttatcttaca ggtgaaaaac caagtgacgc ttttgtagaa atagctactg 115560tgtctgctgt agtattaact cccttttatc aatgccttct cctggacctt gttttattat 115620ttagttagtt gttggttgga ttatttattg ataataaact ttatttttga ataattttag 115680atttacagaa atgttacaga gatggtgcaa aattactctt catgcagctt cccctaatgt 115740taatatctta catacccatg cctgacccca ttttaaacat gtaatttctg gtcatttccc 115800gaatagcagg tgcagggtgc ccagaagcag ttcaagaact ttcagatcga ggtgcagaag 115860ggccgctaca gtctgcacgg ttcggaccgc agcttcccca gcttgggaga cctcatgagc 115920cacctcaaga agcagatcct gcgcacggat aacatcagct tcatgctaaa acgctgctgc 115980cagcccaagc cccgaggttc gtctccctgt gccagagcca ggctgtatcc catcagtaat 116040gtgctgagac ccagatcgac caaaacacgc tgactgactt aaacaaagtg gaccctcccc 116100acagtttcta ggtgtttttt attgagttta attacacttc tgtgcccaac tcacatccaa 116160tcccttgagt gtgagcattt tctgtagaag aggcatatac ctttctcagc atctcattag 116220gctgcagaaa gaggcatgct cagcattagt aagcagaaaa tcacttcttt cttccttaag 116280ataaaatgcc ttgaggagtc tcctgtcact ggtttattta tctgagagat attcctggca 116340catcttttgt gggccaagaa ctatatcaga tgcaaagaat cagaaatgca taaggtccag 116400tccctgctct ctgggggttt cccagcctaa tgctgatgtt acaggtaaat gaggccactg 116460cagtttgtga tgggtgtttt aactaacata gatatcatac cctggagtca aacagaaagg 116520gatggtcaaa atccctgagt tccgtggcac agggggctgc ctggaggagg cagctcttga 116580actgagtgtg ggaggatgag tgggaggttg ccagtgcggt cagggcatct cggcacgtgc 116640aaacagaggc atgggcgggg gctgccatga aggtgaaggt ggaaggaagg tgaaggtgga 116700agggaggggc aggtgaggct gagcttaggg tgtgggggcc ttgagtgcta tgccatggag 116760ctgggtcttt atcctgcagg ctgtaggggc cagggaggat cagggagtga aatggatcca 116820agggggagcc actcagctgt ttcttgttaa gcctcttgaa tggcgtcact gatgttctgc 116880aggtggattt gtctcttaga atgtgaggac tggaaagaca cgtagaggtc acacagtcaa 116940ctgtctcatt ttatagatga gaaaattgag gcccagaaga gcgaagtggg tctcatcaaa 117000ggtcagcgtc aaagaggggc ttgagtgcca ggcctaacct gagtgcccta gctcttgaga 117060acggtttatt ttgctgctcc tcacctcaag atgctgccct tcatgcgtca ggttcttccc 117120ttagaaggag gaaggcctca aagaaggagc agcacgattg ccactgaggc cccatgagtg 117180tcagaggaag accctctgag gagtctttat ctgggacaca tcttgttctt ccaagcgaac 117240gtgtccataa accctcacac caccaggagt gggcagagga agcagcacca ggatagaaag 117300ggacctgggt tcttgatgtt tgaatcagtt tttggtctca gcaaggggct tgtcactgaa 117360cttggtgaaa gaggagggac ttgtgttctt gatcagatag gggttcctgc caggctcaga 117420gaataactgc agcctttgtt ttcatgcttg aggattttcc gcaaaggtaa aaacacatct 117480gccacttggc tgtgagacct cagagtaagt tcaaacctta aagcccaaca gccctattta 117540ttcacagcaa cacactggaa cgaaccccag ttgaggctcc tgaaactcag tgctgaatgt 117600gtttcctgtt gcctttccca cctgactgtg aactcttaag acaggacctg agtctcactc 117660accactctat gggctcgtgg ggaggacagt gcccagcacg gagtcagcgt gaataatgcc 117720tgtcaagtga acaggtagca ggagctgctg gatggtgggt gcctactgtg gcccaggcag 117780tttatgtacc tacctcattt atttcatcta cacagtagct ttttgtagat attacaaagg 117840tgatgaaatt gagacttgag atggtaagtg acttgctcaa ggccatgtag ctagtagtat 117900cggtagtagg tagaacagta gtaataatta ataagaacgg ctgctatcat gtgagcaggg 117960cttacagttt gccaggcgtt gtttggagat ctttcatgtt ttaagtcatt tagtcctcaa 118020aataacccag aatatgttgt tatcccaatt atacatgccc aagatcactt aggtagagga 118080tgagtgggga tttgaactca cgttgtctga ctccaagtcc agtgattcct tctgtaccac 118140tgcccccacc ctgcccaggt cacactgtct ttggaaaggt gcagccatca gcctaggact 118200ttagagcagg caccaattct cctgaccttg ggagagtaag aataaggcct gtgtgtgagg 118260cctccttaca taggtccccc aaagctctct ctcttccctt tgccatgtgc aaattagaga 118320agtggggaaa tcgtgaaaat tagacatgag aatattgtgt tgggttcttc agctcctctg 118380ctctcctaac cacggggttt tgatagccag accctgatct gggtttctca cttgaaaatg 118440caactaagaa actcttcatg ggataaataa aaagcaaagt gaaaaagcag gaggccattc 118500agagtgggcg tgacggctca gcaggtccca catctctagt cctgtgtcct gtgtccagct 118560ccactaccca tctcccactc cagaaccctg atgatacagg aagaatgatg acagtgacta 118620agatgtaatg ccagtcataa tcacggcggc aaccagtcag ggagcgtttt actccatacc 118680gggcactgaa ggcagccgtt cccttgcgtc atcccattct tccacacggt aacctatgaa 118740ggacacaact gtggccccca tttttctagt gaggaaacac cttcatggag gcactgtggc 118800ttcccccatt cacattgtta accctggtgc catgttccct gaagtgccca tgcaaagaat 118860agtccataaa tggcttcggt tccatccgcc tctcatttcc caagtggctc tgctgcctgg 118920cctcttgcct gtggacacca gccacggggc cccttcttga tgccttttct cctgagttga 118980gttgagcctg agttgcctct gaatcggatt ttccccaggt aacagagtgg agtcaggaaa 119040atggtatgga gggagcagcc tctggaaaaa gagtgcccag gttgtgagaa caaggggagc 119100ctctccctga gccctgtttc tggcacccac atttgttctc ccgattaggg ccaggtatgt 119160tgtgggaagg gtagagacga gagcatctct gacttcagtg tgaatcctaa gattacgaac 119220tgcctggcct tgggccaatt acttaatctc tcagaatctc tgttttctca tctataaaat 119280ggggataaga atactgtgta ttccacagga ttgtcataag gacaaaggag ttaatgtgta 119340taatgctcat agaacaccgg ctggcatgga gaaaacagtc ggaatatgtg agcttaaaaa 119400attagaaagg aaaagaatgc cctgtcctga gggatagcag ggattagaga cgtggccctg 119460tgcagggacc cggcgctcag cagccattgt ctcccagcgg tgtgtgtggt ggcctccatg 119520ggttgtgcct ggctgttcta cagatgttct tttaggaact tccttctgtt acagtccagg 119580aatcaggact ggaatggcta cattttctcc cctaacttgt tattgtcttc tagtgcagga 119640aagaggaagt gaagggaaat gcatgttcgt tgtcattttg ctaatattcc tgcttcagtt 119700aataaaattg atgaaaacat acaagtcttc agagattccc agaatacttt ccctgctagt 119760cagaatctgg aaggtccttt cttgccttat gataacctcg ttccttgcag tagctccata 119820gcgggaaagg tgatttctat ggattgtaga tttcctggcc tcgaggattt tgtaatgtgt 119880tgggtttgct gtttgaatca gtagaatctg ggggatagtc tacttaaacc tgcatattga 119940gggggcattt ggtaagcgcc tctccatgtc aggcactgct ggtaccacga gcttcagaca 120000gggcactgtt atgggtctcc tgccctgatc ttctggctca aaaccagcgt ttgttcacct 120060cctcctctgg ttcccatcat gccctgggcc cgggtactgc ttcttccttc catagctctc 120120atcctttaga aagacgccag tcattcattc actcatttaa caaataataa ttgagtgcct 120180actatgtacc gggctgtgga ggtggagaag aaaataagat agacagtctc tgacttcttt 120240cagtttccag tcttacattt taaattttaa tttcattagg gaaactgttt ctgacctttc 120300ttaccagaac agatcttgcc atgccaacct tggagcacca cacacctgtt ctttagagga 120360gctgaacaaa ttgtagcttt ccatttaatt gtttatttgg gagttttggc tctgtcgtta 120420ccctctgagc tcctggaggg taggagccat atgcctattg aataagcact tgtcgaatga 120480ctgaagcagc aagcgcccgc acaccggtcc cacggccccg gctcagcaga cgttggctgt 120540ctgagagctc ggatcttggg tgctgtgctc agactccccc aatctcttcc acagaaatct 120600ccaacctgct ggtggctact aagaaagccc aggagtggca gcccgtctac cccatgagcc 120660agctgagttt cgatcggatc ctcaagaagg atctggtgca ggtgagtcac ggctgcaggg 120720tgtgggccag ctgtggtcct gcctccccac gatggagcag cttggggatc tgggggaagg 120780aaggctgtgt ttggggaaat cttagtagaa aaagaacagg gagactttcc tttgatggca 120840aaagccgtac aaccattgcc tccatcctct tcacccttgc tgatgctcct cagagacatg 120900ttttgaggta agtggtttgg tcaggctttg tggggttacc tagaacagca gggaccttct 120960gtggtgagct gaaggggtgg cagggcagga ggtggctctc cacaggggag catggccatc 121020acacctcgct gcctgcagca ggctgtgtga tggagcacct ccagagttca gtcctgcact 121080ttctgatgat gcttccagaa ggagcagagc tcaggaggag agaacacagg gagggaacaa 121140gaggacatgc acactctggg cctgaaggag aactatcttg agaaacagat cccagtcttt 121200ggaggccttt ttgcccagaa tctacaggct gagcggggag cccaggatct ccccaggggc 121260tgccctggag ctgttgctgg tggtgtgagg cccagggaaa gcccactttc tgttctgcca 121320ccgctcccca gccctgttgc atagggccac gcgttggggt atcagggaga tggtgcggca 121380gccttggaga gaagcaagca cggggccact caccacctcg ggagatggca gcgccttgga 121440ggtgttggag ggtgaggcgg aagctgcctg ctgtgaagga gcctggggag agtggcactc 121500gggggtttgt tactttacct ttttcagtga gtccccgaga ttgttggatg gggcttgagg 121560gagtggaaat ccacagctaa actgcctcac ttccctcgtg gtacatttct tcaccaaagg 121620cccatcattg ttctctattc ctctcgtggt gtgagagctg tgtcctgaga ttacagtcac 121680cagagccaca gtttcatagc ctcttttctg tgtagaactt gacatagtct gtggggcctg 121740cctcttttcc cttgcctcga gcctccaagc aggtaaccac catcctccat gccttccaca 121800tccacttagc caacagagat caagcattac acgtgcgagg cacgattgct gcttcagcag 121860gctcctgtct attttgaggg ggtaatcacg ttagcaagag tcaagttcca aagtagggaa 121920gtacagcagg atgtggacct aatcttgaga ggacggagat agcttcctgg gggaagcggt 121980atcaaagcag agtcccagac caggcacagc ggctcacaca gtggctcaca cctgtcgtcc 122040cagcgctttg agaggccaag gcgggaggat cgcttgagcc taggagttca agaccagcct 122100gggcaacaca atgagatccc atctctacta aaaatacaaa tgaaaaaatg agctgcgtgt 122160agtggtaagc agctgtagtc ccagctactc aggaggctga gttggaagga ttgcataagg 122220ccaggagttt gaggttgcag tgagctatga ttgtgctgct gcactcccgc caggtgttag 122280agcgagaccc tgtctgggga aaaaaaaaaa tcagggtctc ctcctggagg atgaactcaa 122340gtagctaggc aaggtggagg gaacagcatc agaggaggat gaagtgggcc atatgggcct 122400ttgtgggtcc ctgcagaatc ctgacagcat ggtgtcatga cttggccacg ggaagagcaa 122460ttattctgaa agcatatggc ttttacggga tgttctggga atacagcttc ccataacctt 122520gatggatcac ttcatgacag atgcagcttt aatgaatagc caaagacctt gccaggatac 122580agcagacagg gtggatgcat cgccattcgg ctctgacaga taacaaatgg tggcatttgt 122640gcaaattaat atacctgatt aacaatggtg tatgttccta tgggggataa gactgattcc 122700ctaggtatca gtgacagtcc cttttctgca tttccagggg gtcctcaaat aatagaataa 122760tggatcttca gtttacaagt tttgtggtgc taatgtcaac aacttgacat tgcctaagtt 122820tcgtgaatcc catttcgatt tccaaatatt aagaatttta aaagcagaat tattgcaact 122880tgaactggaa gggtcctcag aaatagatca tggtatggct agggctttgc acggatcatc 122940tcattcagtc ctcctgccac tcatctgggg gtattgttcc ctttcacatg tcaggaaatc 123000caggacacat caccccaggc tccaccttca tcttcacatt gccatctcct ctgtgaggtt 123060gccagggcaa atgcaggtgt actttgcacc actaatttta aatcctagcg tgcatgcaca 123120cacatgagca cacacactgg ataaatggat gggaaacaga tggttccagt gtgagaaact 123180gtgcctacct gtgccagagg gcttcagata acacatggat ccaccagatg ggtttctacg 123240catccccccg tgtgcctgag tctgtaccag gagcctccat ccctgtttcc tggtttgatt 123300cttaccacag ccctatgagg tcagtaccat tattacctcc atttgcagaa agtgggcaga 123360gattgccccc atgtcacatg gccagcgggt agtagagctg ggatttgcaa gcctcttcac 123420agggtagcac agcctgtgag tagaggagct gcctgggggc tcctctcttg agtcttctct 123480ggaggcctgg ggtgggaccc atgtggctgg ctgttgatgg ccctgtttgc agtgtcctga 123540catgttagga ctgtgttttg gccaaaggct gttcctaggg gtagaaagca aggagccgtt 123600tagggagtag gaggactgtc tcctggggcc cagcaaatgt caccactgtg tttggccaaa 123660tagcttgttg ttttctctgg aggcctgggg accacgagct ggggcaggga gccctcttgc 123720ctttgcccca tcccattgat agtccatgtt cccattgagg acccattccc agacggtcca 123780tcacttcagg gcacagagag gtcacccagc cttctgcttc ttccctcagg gcgagcacct 123840tgggagaggc acgagaacac acatctattc tgggaccctg atggattaca aggatgacga 123900aggaacttct gaagagaaga agataaaagt gatcctcaaa gtcttagacc ccagccacag 123960ggatatttcc ctggcaagtg tcttcctctg aactcctccc ctcccctctc ccgtttctgg 124020agccagtgga acacaatggg ttgagaagaa cccttgccct tcttgtggcc cagtggtttt 124080caaacttgcc ttttactcag aatttttttc tccacatatg atcttagtgg accctgcatg 124140tagagtaagt gaggtgggtt gaacagctcc tcacactcag cctgtgccct cccttccacc 124200cccaaccccc acctttccta aggacaggtc caggtggctg tgctgtggag ccctaggact 124260ctggccaaat ggttcaaagt tcctgataca gtccatggct ctcaccacac agtctggaaa 124320acgaaagccc agaggagtaa aaggactcac ccaggattct acagactatt agagtgacac 124380agtcaaatct tgagcagaga tcggctgcct tcatttcccc tttgttccag catagtgcta 124440aatatgggta tttcccagag ctgaaaggaa gagagagagg tgggcatgag tatccagtgg 124500gaaaattctt agccagcttc tcccaccagc cctgctctgc atcctgttag gttttctaaa 124560taaacctcac atccctgcca ggttggccca gagaacaagg cttggcagtg cctctggaca 124620gccaaggcca gaggattgat gttcagggcc tggggtggcg acagtggtga gctttcctgg 124680gtccactggc tttcccctca acagagcccc tggggagcag ccccctggag gctggcctga 124740gacattccta tgtcctgctc gcccacaggc cttcttcgag gcagccagca tgatgagaca 124800ggtctcccac aaacacatcg tgtacctcta tggcgtctgt gtccgcgacg tggagagtaa 124860gtgtgttctc tttcaaaggg gtgggtggcc tggctgggga gcttgggtgc tgtggagatg 124920gtggaggctc ttcccaccct cacgttgccc aggcttcttg cctttctttt tgcagttgag 124980gagattgagg gactgagcag gtcatttgct taagttaata gtggaggtgg aactaaaacc 125040aattgctttt cattcatttg tgtaatgttt tcttgtcaac gctggccaag aaccctacac 125100tgtgctagac ctgggaggct gaggtgagtg aaatgaggtc aaggccacaa gagtcaggcc 125160caaggagctc tgggcaggtg agcgaggtga gcgcacccca caagcagcaa gacgctggct 125220cctcgaatgg actggcttcc attttaacca caggcaggct tggccctttc ttggttgtca 125280agccactgag ccggtgggcc cttgggctgc tgctgcacac tgagatggag gggtggcctt 125340ggcctctgag ttcctgacat gtaagtttgg aagaagagcg attttttttt taaccccaag 125400tgacttcttc cctgtggaat ccaacaatgt gagctgttcc gtgtactcac acaggagtcc 125460tgttgagagg gaagttttgc cgtgtgagcg gcctgacctc tgcatcacag tgtgttgtag 125520aacagcagca gtggtggcgg ttgttcccag agcccttgtt ctctgtgtca ggccctccgc 125580caaggctttc caggccttgt gacatttagc cgccatctgt tattacagat gagggaattg 125640aggctcagag aagtgtcact tgctcagtgc caccgtttag aagaagagct tggggttgaa 125700cttggccttt ccagctctga agcccctgca ccattgcacc ccccaaggat atctgtgtac 125760tctgaggccg agtagtgtcc actgaagtgg actgtcgtaa ggggatgaag gagaggaccg 125820tgccacagac caggttccag acatggctat ttttatgcct acagatatca tggtggaaga 125880gtttgtggaa gggggtcctc tggatctctt catgcaccgg aaaagcgatg tccttaccac 125940accatggaaa ttcaaagttg ccaaacagct ggccagtgcc ctgagctact tggtgagaat 126000gtcctgatgt ccataatggt cccaccagaa accagagtgt cctgggaggg gtggcaggaa 126060ggaggtgcta gccaagcagc tagaggggcc tgtccttggg ttccatgggg ccagggctct 126120gtggttgaac aaaggtgtgc ctggtgctta ctgaagatgg tcgtttgggg ccgttccctg 126180tgctcacatg agttctgttt agtgggaaat gttagcacgt cagagggccg acttgcatac 126240tgcagcatat ggatggcaag gctgaaagca gtgcagtacg tgttgagtga atgagtgaac 126300tgccagcatc tagtagctga cgtgtggagt gctcaccatg ggtcagctgt tcaggcgttt 126360cacagattct aatcagtatc atgctcacga agcccaatga gatacgtgcc actatttagc 126420cacattcagt gatgagggag ctggagccaa ggggcacctg tgatgtgcct aagtcacaca 126480gatgattggc agcagggcca ggctgtccag atctggctgt agctgggggt aggaagagat 126540gacctgaggg accagggttg gaaatagaat gcgggaagga gcagcttggc taaacttgac 126600ctttttactc tgcaggagga taaagacctg gtccatggaa atgtgtgtac taaaaacctc 126660ctcctggccc gtgagggcat cgacagtgag tgtggcccat tcatcaagct cagtgacccc 126720ggcatcccca ttacggtgct gtctaggcaa ggtgtgtctc ccctctcttc cctctggccc 126780caccccgagt caggggcaag tcagcagaga gaagggctgg gctggggttg gtctcctttt 126840agagagtcat tttttttttg tattttagta gagacggggt ttcaccatgt tggccaggat 126900ggtcttgatc tcctgccttc tcttaagtcc ttgaacgagc ccccgttcgt cctcctgccc 126960tgggtgatgg cccccaccct gggatgtttt gctgatccta aggccagggc ttcagaagcc 127020tggcttcaca cgaccctcct ggggagcttg gaggcaggga cccatctgct ggctgtgacc 127080cagactgatg tatcagaagt gctggtggtg gcttggaggg ctgcacgcct gcaggccccc 127140cgcacagggc ctatgtggcc atgggccatg tttgggcaca ctgcttgaag tagttccttc 127200attggctcac tgttctggct gcagtgacag taattgaatc cctaggagat cccagaaact 127260gctccatcag tgtgtctgtt gtcttccaga atgcattgaa cgaatcccat ggattgctcc 127320tgagtgtgtt gaggactcca agaacctgag tgtggctgct gacaagtgga gctttggaac 127380cacgctctgg gaaatctgct acaatggcga gatccccttg aaagacaaga cgctgattga 127440ggtgagcagg tgtttcccgg ggcgtgaggc aagtgagggc tttcaggtgc tcgtgggctt 127500cccaggagtt gtcggaagcc tggcactgtg ggaagagatg ggcatgggtt tgaatctctt 127560cacgggccta ctgggtgtgt gacctcacaa atgtaactga acttccgtga gcctcagttt 127620catcatctat aaaatgggga taatcagtaa ctacttgtag ggttgttgtg aagattaaat 127680aatgcatata gagtgacagg catgcagtac aagctcgata gatgttatag tattatttat 127740ctgagatttt aagtgcctgt tattcagcaa aattaccaca caaatacgta tggagttcct 127800attgtgtatc aggcatcaag cttgggaaaa gctggaggtt cactataaaa taagatacag 127860gccttgcctt cccttgaggg ccttagggta tggtagggag ttaggctaaa ataacaacgg 127920taagaattcc agaaagaata cctgaaagtg tcaccctaag agccctgcaa attaggtagg 127980atggtgtcat taccctcatt tgacagatca ggtaactgag actcaggtag ccccacttac 128040ctgggttcct cagctagaat gcaaaacagg cgaggtgtgg acctcctcca aatctacctg 128100tggaaaaagt ggagactcta actccaaagg ggtaaagtag taaaaatcac aatgaaagac 128160cattgtccct tcatctcagt gactgcaatt ggaatgtgct cctgttgttt agagggggca 128220ggcatcagtt tcggctgtga gagcctggtt tcagtgctgt gtcgggagcc tgggtagttt 128280ggtgtgcctg gccttgagtg tctggagtgg ggaaaggaat aacagtgatc aggtgggaaa 128340ggccatttgg gttcagattt ttaaagtccc tgattccagg ctgcagaacc tacattttac 128400tgggggtggc atgggacaag gaaggatttg ggtggaggag ggaggggctt ggaggtcggc 128460cttgggatgt tcttctggat gcagtagctg ggatggacag aggagagacc tggagggaga 128520caggggcccc gagtctctca gcaatgggag ccccatgtcc ggaaatggca gcggaagtcc 128580agagtgcagg gtgggagata ttgaagaggt agaaccttta tgacttgcca gttaatgatg 128640gtgcaggact tgggaaagga tcttaaaccc gcagggaaac catcagatct acagatctgc 128700tatttggaat tttcagccta ggcttttggg aaattcatat ttatttttaa cttccttgga 128760tccttggaaa tgaaacaaca taccctttgt catcagtcag tatttattga gcacgtgctg 128820cgtaccctgg gctgaacagc atacagggtg gtgtaaggaa ggacccgtgt ctttaataaa 128880ataggggtct ctctccacct aagtcccctt gggttagatg gcttttctgc aggctgcact 128940gacgcaggga tgtgtgagtg acactcaagg acaagagcaa ttctcagctc cttaattcca 129000gtcctccctc ctccctgtcc tctggggcct gcccacccca ccccacccca gggcccacgg 129060ggaccagaga ggaacttagt acccttggag tccagctatg aagtagaaac tggaatgcag 129120tggtttcact tcatcttcca aaagtagcat aagttcttgt ttctaaaatt taaagtaata 129180aacagttgaa gaaaattttt aaaatgaaac tattaaaaaa agaaaacagc aatcactgca 129240ttcttgtcat ccctgaccac tgttaacact ttggcatttt gtcttccagc ctgtttgtat 129300ctctcttttt taaacaaaat tggggccatg ctagatagag ttatataaaa ttctgagttt

129360tttcatttaa tactgagaat gctttcctgt gagattaaat cataattttt acaaatttaa 129420tgtaagagtt aattgttttg tttaatttac ttgactaatt ttatatttgg catttaagtt 129480ttcaaatttc cagtgttctg tctaattctg caggaaacat ccttgtacat aaatatttgt 129540tcatatctga tttatttctg agtcattcag tcattgaagt taatgcatca gagggtttga 129600agaatctgaa gatttttgta catgttgccc aattgtattc cagaaaggct gcatgccttt 129660acttgaatga agctttttgg gactgggcta tagtgcccag tctccttgaa tttggactat 129720tcagtattag gactgtgatt tccccttgca agaataaggc agcagtaaca aacacttacg 129780aaatctacct gtaagtggag atgttgagaa tcgaatgagg aattggcaat tccacctgac 129840ctggggctga gaagtttgta ggtggttcct ttggtttctt ccatgtgccc ctcttgttta 129900cagaaagaga gattctatga aagccggtgc aggccagtga caccatcatg taaggagctg 129960gctgacctca tgacccgctg catgaactat gaccccaatc agaggccttt cttccgagcc 130020atcatgagag acattaataa gcttgaagag cagagtaaga cctgccatgt gctgctttaa 130080cccagcttgg ggagaaacag gagcctgggt ggcaatccct ggcaatcgac tgcctttcac 130140tctgttttct tttctcttct gttagatcca gatattgttt cagaaaaaaa accagcaact 130200gaagtggacc ccacacattt tgaaaagcgc ttcctaaaga ggatccgtga cttgggagag 130260gtaagttaca cccgtgctgc ttgctgctga tggcagagcc ctccgccatc cacagcgcca 130320ctctctgcac gtacagctgc tctccattct ttttcattct ggggccaggt ccatgagcga 130380aagcacctta ctgcatttgg gggccacttt catcacaagg gattgtgtct ttctccatgt 130440gacacacggc acggacggaa tgcacgtccc tgcctgcatg cacgactgtg tatgcacacg 130500ggactctggg cagctccctt gagagacttg agttttctct acaggacaga agagaatgga 130560aagagggaga gatgggggag taggtataga tatggtggaa taggaaaatc cttgcctctg 130620actttcccgg gcatatatat cctgtaagct tctctctttt tcttttgccc ccgagagaca 130680gggtctcgct ctgtgtccca ggctggagtg agtggtgtga tcatagctca ctgcagcctc 130740aacttcccag gctcaagcaa tcttcctgcc tcagcctcct gagtagctgg aactacaggc 130800acacgccccc atgctggcta atatttttta ttttttattg tagaaatggg gtcttgctat 130860gttgactagg ctgctctcag actcctggcc tcaagcaagg aggcctccca aagtgctggg 130920attataggca taagccacca tacccagccc tgtaaggctc tttagagcag ggataggttt 130980attgcacaga atcccaaaat agagtgtcag cgtttctttg gaccttaaat gggagtttcc 131040aaacagttaa ttgtgactag agaagctact gagatttgtg tctttataca gattttctgt 131100agtctggtta atgaaacaga cttgatacat ctccaggatc tgctgtgtgc cagccactgt 131160gccaggcatt gtcagaagca tggcatcctt agttcccccc accgtccccg aggccagttt 131220ctgtatgcag cgagtgcatc aggagccagc tccgatttgg ggacttggcc accactgtcg 131280ctgtcaggtg gcttggctgg aacctgatct cacgtcttct aaagactcct catgcatttg 131340ctcttttcag ccatgctgtg gggcctgtcc tgtaacgtga gcccagggct tttagagaac 131400ggcagttgtc ctgcaggccc agaaataacc ttcatttcct gtggtcatag aaattgggat 131460tgatgagttg gttcatcgtc acctgctact ttgtcttggc tcagtaactg aggggacagt 131520ttgtgaggcc aagagagcga gggggctgta gtgagcaagt acagtccagg tgagaggctt 131580ctgcctgcaa ggccagacag cgagaacccc tggccctcag gggaacggct gtgaggagca 131640agacttctgt gtgttccgtg gcctacgatg gggcttccct gataacagca catgcatctt 131700tccctccagg gccactttgg gaaggttgag ctctgcaggt atgaccccga aggggacaat 131760acaggggagc aggtggctgt taaatctctg aagcctgaga gtggaggtaa ccacatagct 131820gatctgaaaa aggaaatcga gatcttaagg aacctctatc atgagaacat tgtgaagtac 131880aaaggaatct gcacagaaga cggtatgtta tgcaaggctg gggtccggtt taaagatttg 131940gtgactgtct agggtcataa aggccagtgc aaaacaggca ctccgtggcc ttacctgggc 132000gtctgacatg ctagctggtg gttcccacac actctcaagg cttccaagtc atatgtcaaa 132060tccctcagca gctgcagggc tcctgaggag gccacccagg cccctccatc caggggctgg 132120ttccagcact gtctctccac gtcacttgca cttatgcctt atgaaactga ttcctactct 132180acctccaccc acttcctgtt ctgatccaat actagccagg gtatttcatt ttctagttgt 132240ctaaatcaaa gtggcaagta atatttacta ataattgtat cttatttgca agccagcatc 132300tactcatggt agtgaaattg acagctgatg ataatttttt tttttttttt tttttttttg 132360agacggagtc tcgctctgtg gcccaggctg gactgcagtg gcgcaatctc ggctcactgc 132420aagctccgcc tcccgggttc acgccattct cctgcctcag cctcccgagt agctgggact 132480acaggcgccc gccatcacgc ccggctaatt tttttgtatt tttagtagag acggggtttc 132540accgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcccgc ctcggcctcc 132600caaagtgctg ggattacaag cgtgagccac cgcgcccagc ccgataattt ttgaaaacag 132660tcatttgcct gtggtttaca gagcactctg actgttatct cagtgagtgc ttatgcctgt 132720gaggtaggta caccattgtt accatctcca ttcactgctg aggatcttga ggcataagag 132780gtcaagtaac atgcctgtaa tgaaggggcg aagctggcgt cacctcaggg cctctgtctc 132840atatcctgtg cccttgcctc tcccatggtt ccctcatttg gcagcctcag actgatggat 132900gttttttcta aacaggagga aatggtatta agctcatcat ggaatttctg ccttcgggaa 132960gccttaagga atatcttcca aagaataaga acaaaataaa cctcaaacag cagctaaaat 133020atgccgttca gatttgtaag gtaaaaaata aagacatcat gttacagatt aagacatcag 133080gcactctgtc ctgggtaatt ggtttgtaat ttgactctaa gtgggtaagt ttatgataat 133140tatactgttt gtttttctct gcattattta gatgaaaagt tagcttctac taagaaagta 133200aacggattta aatatggtta ttttaatgtg tatttatttg aatcagtttg ttcttaatat 133260tcttgcataa aagtcagaac caaaaaaatt gtcagtgata tgtgaatgaa atgacatttc 133320tattttttct gatgaagtga tagataatac aatctaaagt gactttagca atgtgcttga 133380cttttacttc tctctctcag gggatggact atttgggttc tcggcaatac gttcaccggg 133440acttggcagc aagaaatgtc cttgttgaga gtgaacacca agtgaaaatt ggagacttcg 133500gtttaaccaa agcaattgaa accgataagg agtattacac cgtcaaggat gaccgggaca 133560gccctgtgtt ttggtaactg aatcaaacca ctaggtttta tcaatgcttc atagagttta 133620cactgtttta ataggccctt tctggctata ttaatgtgtc tcattcctct ggcctgactc 133680aaggttagag aaggtttaga acatttggaa ttgattgata tttatcttca agaaacacac 133740ctttcagcct gtttcattga aagcagccta tataaatgac tgagcttcat atgacaccgt 133800cttccaagga atgaaagaaa tctaaccacc agctcaacat tcctagcttt ccaggagagg 133860gcattcatct gatgcagttc ttaaaactgt gagcaggtgg agagaatcta gttcctttct 133920taaacacatt cctgcagagg gaggctgtag gacagagtgg gcattgcaga ttcagggaac 133980tcctggacag agcagagcaa aacctacggg agacctggct gtctcatgaa tcaccagagg 134040ttcccaggtt agaaggccac acactggcta caaccatgtc tcagccggga acactgtcca 134100ggggagaggc tgcttacatc tctaccgcac cctgccacgt aaccacataa cgacataacc 134160aatcagcact cccctaggtg catcctacat ggacacaaac atagacctct cccacttatg 134220gagcctaaac ttactcattc attcatttaa gaaaatgcat caaggtcctg ctttgtgcca 134280gtactggaga tatggtgaac aagtaggccg agtttagagt ttaacaggct aggcagccaa 134340cggcatggag caggaaacat acagaagggt tcgggcttgg ttttctggaa gtcgtgagta 134400ttcagaagaa acctgaaaga ttcatgcggg tttagacaga cggttgctag acagcatgcg 134460tgactaggaa gaatgagaca agagcagtcg atttcccagg aactgaacct cagtgaggtc 134520agatcatgga ataggaggtt tgcaggagga agcttgagtc atggagctgg gacttcatct 134580caagaacaat gggatgctgc tggagagttt aaggagggag actttgtttt aaaaagacca 134640ccactgaatg aagggaacaa gattggagcc agggagtctg gagccaggga gtctggagcc 134700agggagtctg atttggctgc ttcaacagct caggccagag ctagtgacag catgaattag 134760gacagggact gggagagtga cagtagggtt tgagagaagt gagtaggttc aaggagtata 134820taaggagatt gggtgcggtg gaatgccttc atttttggct tgggcaagtg ggtgtcattc 134880agcaaagtag gcaatgctgg aagaggattg gacagcgatg ccacattgtg cagtgaggcc 134940actgctgtct catttagagc ctgcaggcaa atcagacctg gggctcatca ttacacggcc 135000acctcctccc ataccctgag agcatgttct cagtgaaatg aagagcacag acttggcgtg 135060ttattttagg gcagatacgt gctaccgaga gcctgtaaag gataccgtac tataggtcag 135120atgtgcacca tagcagcgta tacatggtat gtgtaaaata tataatacac agtcagatgc 135180tgtattaaat tataagaaaa accgaagagg tgatttttca gttatcctgt aatgtcggat 135240ggagtgtgcc tcccaggaaa tgaagttttg tgttctgctt cctttcaagg tatgctccag 135300aatgtttaat gcaatctaaa ttttatattg cctctgacgt ctggtctttt ggagtcactc 135360tgcatgagct gctgacttac tgtgattcag attctagtcc catggctgta agtcctactt 135420ttctcttcat ttgaatccag tacccattta aaatgtgtcc atccctctgc ttggttaact 135480tttgttttta aatggaatcc aatgaatgta ttataatgga aaatgtcact ttcccattaa 135540cttggtttgc tacttgacag ttatttgtga atctctaaag tcttgctttc acaacgagcc 135600cggagttcta taggatgacc ttgactctca aggatcttat ctgtgtagag atgaagggca 135660gttttatggg aaaatgagca agttaagtgg ggtagcactg ggtagggacc agccttgtct 135720gtgcctcctt cattcctaaa tcagatcatt ttcttgggaa cagactcctt gaccagcaca 135780agcacaagga gtggttggta gagtctaaga cactggttag agacagatca ttgaaagcta 135840ataaggattt tggattttta tttaaagtta ctaaggagaa aagccttttt attgctactt 135900aaatttccag ttgattgtag aaatttcacc ttaatctgtt tggcatttat gtaaatactt 135960gcaaagttaa acgttttgtt tgattttatt ttatatagtt gttcctgaaa atgataggcc 136020caacccatgg ccagatgaca gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc 136080tgccgtgccc acctaactgt ccagatgagg tatctatggg ccacgtcaca gtaataacac 136140tccatttcta ttatgttttc gcagcttgag ttgtccagca atgggtagag gggagagcga 136200ggaaatgatg cagtgaagtc cttgtaaaat agttttctga agctgaattt cacataagat 136260aactgagaaa tcgcctttgg ggctagatga tagccaccag ttaggttcag agcaaggatt 136320ccctccaaaa gccagcccct ctttatccac ttgcttgccc cagagggaca ggttttggtg 136380tagccttagt gtgacaaata catataattg cattttttgt gtgtaagttt atcccactta 136440ttagcattta taattcagtt ttctaagtga attgagcctt taatactaaa ctcttgagac 136500tgtgtaagac acactgaaca gtatgagtca gagagtgagg cagccagtct ggaaagttca 136560agtctgaact gagattctgc ttcaccctct aactggttta caggaatgac ctggatttta 136620ttgcagccag tcaacccttg agcttctcaa atgttaaaat attatttatg aactagagtt 136680gtatcccatt ttctgtgttt taaactattc aaatactctt gtttttctag tctttaagga 136740aaagtcattg catttccaaa attattttct tactcttgat atttctgtta ttttttaaag 136800ttcccagatc taacattttt actgttgtta cttctttctt tttacaggtt tatcaactta 136860tgaggaaatg ctgggaattc caaccatcca atcggacaag ctttcagaac cttattgaag 136920gatttgaagc acttttaaaa taagaagcat gaataacatt taaattccac agattatcaa 136980gtccttctcc tgcaacaaat gcccaagtca ttttttaaaa atttctaatg aaagaagttt 137040gtgttctgtc caaaaagtca ctgaactcat acttcagtac atatacatgt ataaggcaca 137100ctgtagtgct taatatgtgt aaggacttcc tctttaaatt tggtaccagt aacttagtga 137160cacataatga caaccaaaat atttgaaagc acttaagcac tcctccttgt ggaaagaata 137220taccaccatt tcatctggct agttcaccat cacaactgca ttaccaaaag gggatttttg 137280aaaacgagga gttgaccaaa ataatatctg aagatgattg cttttccctg ctgccagctg 137340atctgaaatg ttttgctggc acattaatca tagataaaga aagattgatg gacttagccc 137400tcaaatttca gtatctatac agtactagac catgcattct taaaatatta gataccaggt 137460agtatatatt gtttctgtac aaaaatgact gtattctctc accagtagga cttaaacttt 137520gtttctccag tggcttagct cctgttcctt tgggtgatca ctagcaccca tttttgagaa 137580agctggttct acatgggggg atagctgtgg aatagataat ttgctgcatg ttaattctca 137640agaactaagc ctgtgccagt gctttcctaa gcagtatacc tttaatcaga actcattccc 137700agaacctgga tgctattaca catgctttta agaaacgtca atgtatatcc ttttataact 137760ctaccacttt ggggcaagct attccagcac tggttttgaa tgctgtatgc aaccagtctg 137820aataccacat acgctgcact gttcttagag ggtttccata cttaccaccg atctacaagg 137880gttgatccct gtttttacca tcaatcatca ccctgtggtg caacacttga aagacccggc 137940tagaggcact atggacttca ggatccacta gacagttttc agtttgcttg gaggtagctg 138000ggtaatcaaa aatgtttagt cattgattca atgtgaacga ttacggtctt tatgaccaag 138060agtctgaaaa tctttttgtt atgctgttta gtattcgttt gatattgtta cttttcacct 138120gttgagccca aattcaggat tggttcagtg gcagcaatga agttgccatt taaatttgtt 138180catagcctac atcaccaagg tctctgtgtc aaacctgtgg ccactctata tgcactttgt 138240ttactcttta tacaaataaa tatactaaag actttacatg catatgcctt ttaatattaa 138300gatttcattt tcaaagcatt tcaaacaatt tgcttacata gaaaaataac agtatagttt 138360tggggggagg aaggggtggg ttacggtcct tactactaac aaacaaacaa acaccacttg 138420atttgcactt cttcactgtt gtgcccagtg attgataacg gggcacaggc cagtatggat 138480ggcatgtcca ctgtgctgta gtccagacac ctttgtttgt ttgttttagt tccttcaacc 138540tcttcctgct ttgactgact gactttttgc agctctgttg caaaattcac catctttcct 138600ttcttctgtt tgtttgtttg tttgtactat agtggaggtg tgactaagca ttgaagaggc 138660tgaatgcaac aggaaaatgg gaaagagaag tgcagggcct gaaaaaccca ttagtcatct 138720gctatatcac tgaatgatgc ctaattctta tcagttactt ataggtagta tacttagaaa 138780ttaccttaaa ctttctagct gtcagtcatt ttccaacaga agctagtata tgcaataaat 138840tagaccaagt gaaattcttt acaaagcata caacatatgt accaattcta gacttcataa 138900ttaaaacagg atatccacat catagttaaa aataacaagt ccccaaagtg acgagatatt 138960taatgatctg atttcaaaaa gccccggatt gagatcccaa attccctatc aattaattac 139020agtcttataa cataaacaaa cttagaaatt tctagatggc aaaaggtttc tcatgcattt 139080aataccaagg tcttcaagaa atggtgatgt caaaagtcat catagtccat aaagataaaa 139140cttctttcac aagtaaattg ggttaaataa ctgatttttc accctaacac actatcaaaa 139200agagtgagag agaaagcaga gagtgaggta tagcttatta gctcaaaatg gttataaata 139260ctgtgactcc ttaagactcc atcagaaagt gcagtattga ctgctttact atactatatt 139320gtggaaataa tagggcattt agtgatcaaa ataggcccca ttctagtcat tagatcatta 139380ctagtctacg ctatgaaatg agcacagaaa cccatgttcc tttccactta caagtctgtc 139440taaaggctaa aggtctgtct ttaggtgaat tgaaaggaat agttgctatt agaattagtg 139500ctattagatc agggatcagc aaactatata taaatggcca gatacttgaa attttaggcc 139560atatggtctt tgtaggccat acagtctctg ttgaagctaa tcagttctgc ccttgtagcg 139620taagagtgcc acagacaaca cgtaaatgaa tgagcatggc aacgtcccaa taaaagttta 139680tttatggaca ctgaaatctg aatttcatat aaatttcatg tcataagttt tcttttttcc 139740tccaaccatt taaaaatgta aacattagtc ttagcttgca ggcagcacaa aagcgggtgg 139800tagaccaaat gtggacccag ggtgtagttt gccaaaccct tttattagat caccaaagtt 139860acttttctta aaataccttc tatttttcac agaaggtata aatggtaaac aacatcttaa 139920agcatcggta gtagtggata ccttggatat cactgtcact ctcttaccgg gtttaatttt 139980gcatggctgg tgtgggcgta attgagtgtg catgtagagc atctttataa tattaccatc 140040agcacatttg gtacttgcac ccttgtagtt ctaggaaaag tcctaaaaat ctataaatgc 140100aattacttct agggaaagta aattgaaatg cacattggct tataagaaac tcattcttct 140160aaggctcagg aaacaacact gtttcccatt tattgcttca aacttctttt atatatggtg 140220tcagaattat tcccagtcct aaatcaagga atattggaac attgttagtt tctccaatgg 140280at 14028241154PRTHomo sapiens 4Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 1 5 10 15 Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 20 25 30 Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 35 40 45 Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 50 55 60 Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 65 70 75 80 Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 85 90 95 Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 100 105 110 Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 115 120 125 His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 130 135 140 Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 145 150 155 160 Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 165 170 175 Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 180 185 190 Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 195 200 205 Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 210 215 220 Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 225 230 235 240 Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 245 250 255 Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 260 265 270 Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 275 280 285 Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 290 295 300 Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 305 310 315 320 Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 325 330 335 Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 340 345 350 Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 355 360 365 Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 370 375 380 Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 385 390 395 400 Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 405 410 415 Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 420 425 430 Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 435 440 445 Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 450 455 460 Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 465 470 475 480 Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 485 490 495 Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 500 505 510 Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 515 520 525 Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 530 535 540 Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 545 550 555 560 Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 565 570 575 Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 580 585 590 Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 595 600 605 Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 610 615

620 Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 625 630 635 640 Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 645 650 655 Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 660 665 670 Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 675 680 685 Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 690 695 700 Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 705 710 715 720 Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 725 730 735 Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 740 745 750 Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 755 760 765 Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 770 775 780 Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 785 790 795 800 Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 805 810 815 Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 820 825 830 Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 835 840 845 Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 850 855 860 Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 865 870 875 880 Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 885 890 895 Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 900 905 910 Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 915 920 925 Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 930 935 940 Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 945 950 955 960 Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 965 970 975 Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 980 985 990 Tyr Leu Gly Ser Arg Gln Tyr Val His Arg Asp Leu Ala Ala Arg Asn 995 1000 1005 Val Leu Val Glu Ser Glu His Gln Val Lys Ile Gly Asp Phe Gly 1010 1015 1020 Leu Thr Lys Ala Ile Glu Thr Asp Lys Glu Tyr Tyr Thr Val Lys 1025 1030 1035 Asp Asp Arg Asp Ser Pro Val Phe Trp Tyr Ala Pro Glu Cys Leu 1040 1045 1050 Met Gln Ser Lys Phe Tyr Ile Ala Ser Asp Val Trp Ser Phe Gly 1055 1060 1065 Val Thr Leu His Glu Leu Leu Thr Tyr Cys Asp Ser Asp Ser Ser 1070 1075 1080 Pro Met Ala Leu Phe Leu Lys Met Ile Gly Pro Thr His Gly Gln 1085 1090 1095 Met Thr Val Thr Arg Leu Val Asn Thr Leu Lys Glu Gly Lys Arg 1100 1105 1110 Leu Pro Cys Pro Pro Asn Cys Pro Asp Glu Val Tyr Gln Leu Met 1115 1120 1125 Arg Lys Cys Trp Glu Phe Gln Pro Ser Asn Arg Thr Ser Phe Gln 1130 1135 1140 Asn Leu Ile Glu Gly Phe Glu Ala Leu Leu Lys 1145 1150 55449DNAHomo sapiens 5cacacaggaa ggagccgagt gggactttcc tctcgctgcc tcccggctct gcccgccctt 60cgaaagtcca gggtccctgc ccgctaggca agttgcactc atggcacctc caagtgaaga 120gacgcccctg atccctcagc gttcatgcag cctcttgtcc acggaggctg gtgccctgca 180tgtgctgctg cccgctcggg gccccgggcc cccccagcgc ctatctttct cctttgggga 240ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc agcggcatcc tgcctgtgta 300ccactccctc tttgctctgg ccacggagga cctgtcctgc tggttccccc cgagccacat 360cttctccgtg gaggatgcca gcacccaagt cctgctgtac aggattcgct tttacttccc 420caattggttt gggctggaga agtgccaccg cttcgggcta cgcaaggatt tggccagtgc 480tatccttgac ctgccagtcc tggagcacct ctttgcccag caccgcagtg acctggtgag 540tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt gagtgtctca gcctggccgt 600gttggacctg gcccggatgg cgcgagagca ggcccagcgg ccgggagagc tgctgaagac 660tgtcagctac aaggcctgcc tacccccaag cctgcgcgac ctgatccagg gcctgagctt 720cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc ctgcgccgcg tggccgcctg 780ccaggcagac cggcactcgc tcatggccaa gtacatcatg gacctggagc ggctggatcc 840agccggggcc gccgagacct tccacgtggg cctccctggg gcccttggtg gccacgacgg 900gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc tggacccagg gagaacagga 960ggtcctccag cccttctgcg actttccaga aatcgtagac attagcatca agcaggcccc 1020gcgcgttggc ccggccggag agcaccgcct ggtcactgtt accaggacag acaaccagat 1080tttagaggcc gagttcccag ggctgcccga ggctctgtcg ttcgtggcgc tcgtggacgg 1140ctacttccgg ctgaccacgg actcccagca cttcttctgc aaggaggtgg caccgccgag 1200gctgctggag gaagtggccg agcagtgcca cggccccatc actctggact ttgccatcaa 1260caagctcaag actgggggct cacgtcctgg ctcctatgtt ctccgccgca gcccccagga 1320ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc cttggtcctg attataaggg 1380ctgcctcatc cggcgcagcc ccacaggaac cttccttctg gttggcctca gccgacccca 1440cagcagtctt cgagagctcc tggcaacctg ctgggatggg gggctgcacg tagatggggt 1500ggcagtgacc ctcacttcct gctgtatccc cagacccaaa gaaaagtcca acctgatcgt 1560ggtccagaga ggtcacagcc cacccacatc atccttggtt cagccccaat cccaatacca 1620gctgagtcag atgacatttc acaagatccc tgctgacagc ctggagtggc atgagaacct 1680gggccatggg tccttcacca agatttaccg gggctgtcgc catgaggtgg tggatgggga 1740ggcccgaaag acagaggtgc tgctgaaggt catggatgcc aagcacaaga actgcatgga 1800gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg taccggcatc tcgtgctgct 1860ccacggcgtg tgcatggctg gagacagcac catggtgcag gaatttgtac acctgggggc 1920catagacatg tatctgcgaa aacgtggcca cctggtgcca gccagctgga agctgcaggt 1980ggtcaaacag ctggcctacg ccctcaacta tctggaggac aaaggcctgc cccatggcaa 2040tgtctctgcc cggaaggtgc tcctggctcg ggagggggct gatgggagcc cgcccttcat 2100caagctgagt gaccctgggg tcagccccgc tgtgttaagc ctggagatgc tcaccgacag 2160gatcccctgg gtggcccccg agtgtctccg ggaggcgcag acacttagct tggaagctga 2220caagtggggc ttcggcgcca cggtctggga agtgtttagt ggcgtcacca tgcccatcag 2280tgccctggat cctgctaaga aactccaatt ttatgaggac cggcagcagc tgccggcccc 2340caagtggaca gagctggccc tgctgattca acagtgcatg gcctatgagc cggtccagag 2400gccctccttc cgagccgtca ttcgtgacct caatagcctc atctcttcag actatgagct 2460cctctcagac cccacacctg gtgccctggc acctcgtgat gggctgtgga atggtgccca 2520gctctatgcc tgccaagacc ccacgatctt cgaggagaga cacctcaagt acatctcaca 2580gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc tatgacccgc taggcgacaa 2640tacaggtgcc ctggtggccg tgaaacagct gcagcacagc gggccagacc agcagaggga 2700ctttcagcgg gagattcaga tcctcaaagc actgcacagt gatttcattg tcaagtatcg 2760tggtgtcagc tatggcccgg gccgccagag cctgcggctg gtcatggagt acctgcccag 2820cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc ctcgatgcca gccgcctcct 2880tctctattcc tcgcagatct gcaagggcat ggagtacctg ggctcccgcc gctgcgtgca 2940ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag gcacacgtca agatcgctga 3000cttcggccta gctaagctgc tgccgcttga caaagactac tacgtggtcc gcgagccagg 3060ccagagcccc attttctggt atgcccccga atccctctcg gacaacatct tctctcgcca 3120gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc ttcacctact gcgacaaaag 3180ctgcagcccc tcggccgagt tcctgcggat gatgggatgt gagcgggatg tccccgccct 3240ctgccgcctc ttggaactgc tggaggaggg ccagaggctg ccggcgcctc ctgcctgccc 3300tgctgaggtt cacgagctca tgaagctgtg ctgggcccct agcccacagg accggccatc 3360attcagcgcc ctgggccccc agctggacat gctgtggagc ggaagccggg ggtgtgagac 3420tcatgccttc actgctcacc cagagggcaa acaccactcc ctgtcctttt catagctcct 3480gcccgcagac ctctggatta ggtctctgtt gactggctgt gtgaccttag gcccggagct 3540gcccctctct gggcctcaga ggccttatga gggtcctcta cttcaggaac acccccatga 3600cattgcattt gggggggctc ccgtggcctg tagaatagcc tgtggccttt gcaatttgtt 3660aaggttcaag acagatgggc atatgtgtca gtggggctct ctgagtcctg gcccaaagaa 3720gcaaggaacc aaatttaaga ctctcgcatc ttcccaaccc cttaagccct ggccccctga 3780gtttcctttt ctgtctctct ctttttattt tttttatttt tatttttatt tttgagacag 3840agcctcgctc tgttacccag ggtggagtgc agtggtgcga tctcggctca gtgcaacctc 3900tgcttcccag gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggt 3960gtgcaccacc acacccggct aatttttttt atttttaata gagatgaggt ttcaccatga 4020tggccaggct gatctcgaac tcctaacctc aagtgatcct cccacctcag cctcccaaag 4080tgttggaata ataggcatga gccactgcac ccaggctttt ttttttttaa atttattatt 4140attattttta agagacagga tcttgctacg ttgcccaggc tggtcttgaa ctcctgggct 4200acagtgatcc tcctgcctta tcctcctaaa tagctgggac tacagcacct agttttgagt 4260ttcctgtctt atttccaatg gggacattca tgtagctttt tttttttttt tttttttgag 4320acggagtctc gctctgtcgc ccaggctgga gtacagtggc gcaatctagg ctcactgcaa 4380gctccgcctc ctgggttcac accattctct cgcctcagcc tcccaagtag ctgggactac 4440aggcgcccgc caccacaccc ggctaatttt ttgtattttt agtagagacg gggtttcacc 4500ttgttagcca ggatggtttc catctcctga cctcgtgatc tgcccgtctc ggcctcccaa 4560agtgctggga ttacaggcat gagccactgc gcccggccct catgtagctt taaatgtatg 4620atctgacttc tgctccccga tctctgtttc tctggaggaa gccaaggaca agagcagttg 4680ctgtggctgg gactctgcct tttaggggag cccgtgtatc tctttgggat cctgaaaggg 4740ggcaggaaag gctggggtcc cagtccaccc taatggtatc tgagtgtcct agggcttcag 4800ttttcccacc tgtccaatgg gaccctttct gtcctcaccc tacaaggggc acaaagggat 4860gacaccaaac ctggcaggaa cttttcacgc aatcaaggga aggaaaggca ttcctggcag 4920agggaacagc atgccaagcg tgagaaggct cagagtaagg aggttaagag cccaagtatt 4980ggagcctaca gttttgcccc ttccatgcag tgtgacagtg ggcaagttcc tttccctctc 5040tgggtctcag ttctgtcccc tgcaaaatgg tcagagctta ccccttggct gtgcagggtc 5100aactttctga ctggtgagag ggattctcat gcaggttaag cttctgctgc tcctcctcac 5160ctgcaaagct tttctgccac ttttgcctcc ttggaaaact cttatccatc tctcaaaact 5220ccagctacca catccttgca gccttccctc atataccccc actactactg tagccctgtc 5280cttccctcca gccccactct ggccctgggg ctggggaagt gtctgtgtcc agctgtctcc 5340cctgacctca gggttccttg ggggctgggc tgaggcctca gtacagaggg ggctctggaa 5400atgtttgttg actgaataaa ggaattcagt ggaaaaaaaa aaaaaaaaa 544965053DNAHomo sapiens 6tgcagacagt gcgggcctgc gcccagtccc ggctgtcctc gccgcgaccc ctcctcagcc 60ctgggcgcgc gcacgctggg gccccgcggg gctggccgcc tagcgagcct gccggtcgac 120cccagccagc gcagcgacgg ggcgctgcct ggcccaggcg cacacggaag tgcgcttctc 180tgaagtagct ttggaaagta gagaagaaaa tccagtttgc ttcttggaga acactggaca 240gctgaataaa tgcagtatct aaatataaaa gaggactgca atgccatggc tttctgtgct 300aaaatgagga gctccaagaa gactgaggtg aacctggagg cccctgagcc aggggtggaa 360gtgatcttct atctgtcgga cagggagccc ctccggctgg gcagtggaga gtacacagca 420gaggaactgt gcatcagggc tgcacaggca tgccgtatct ctcctctttg tcacaacctc 480tttgccctgt atgacgagaa caccaagctc tggtatgctc caaatcgcac catcaccgtt 540gatgacaaga tgtccctccg gctccactac cggatgaggt tctatttcac caattggcat 600ggaaccaacg acaatgagca gtcagtgtgg cgtcattctc caaagaagca gaaaaatggc 660tacgagaaaa aaaagattcc agatgcaacc cctctccttg atgccagctc actggagtat 720ctgtttgctc agggacagta tgatttggtg aaatgcctgg ctcctattcg agaccccaag 780accgagcagg atggacatga tattgagaac gagtgtctag ggatggctgt cctggccatc 840tcacactatg ccatgatgaa gaagatgcag ttgccagaac tgcccaagga catcagctac 900aagcgatata ttccagaaac attgaataag tccatcagac agaggaacct tctcaccagg 960atgcggataa ataatgtttt caaggatttc ctaaaggaat ttaacaacaa gaccatttgt 1020gacagcagcg tgtccacgca tgacctgaag gtgaaatact tggctacctt ggaaactttg 1080acaaaacatt acggtgctga aatatttgag acttccatgt tactgatttc atcagaaaat 1140gagatgaatt ggtttcattc gaatgacggt ggaaacgttc tctactacga agtgatggtg 1200actgggaatc ttggaatcca gtggaggcat aaaccaaatg ttgtttctgt tgaaaaggaa 1260aaaaataaac tgaagcggaa aaaactggaa aataaacaca agaaggatga ggagaaaaac 1320aagatccggg aagagtggaa caatttttct tacttccctg aaatcactca cattgtaata 1380aaggagtctg tggtcagcat taacaagcag gacaacaaga aaatggaact gaagctctct 1440tcccacgagg aggccttgtc ctttgtgtcc ctggtagatg gctacttccg gctcacagca 1500gatgcccatc attacctctg caccgacgtg gcccccccgt tgatcgtcca caacatacag 1560aatggctgtc atggtccaat ctgtacagaa tacgccatca ataaattgcg gcaagaagga 1620agcgaggagg ggatgtacgt gctgaggtgg agctgcaccg actttgacaa catcctcatg 1680accgtcacct gctttgagaa gtctgagcag gtgcagggtg cccagaagca gttcaagaac 1740tttcagatcg aggtgcagaa gggccgctac agtctgcacg gttcggaccg cagcttcccc 1800agcttgggag acctcatgag ccacctcaag aagcagatcc tgcgcacgga taacatcagc 1860ttcatgctaa aacgctgctg ccagcccaag ccccgagaaa tctccaacct gctggtggct 1920actaagaaag cccaggagtg gcagcccgtc taccccatga gccagctgag tttcgatcgg 1980atcctcaaga aggatctggt gcagggcgag caccttggga gaggcacgag aacacacatc 2040tattctggga ccctgatgga ttacaaggat gacgaaggaa cttctgaaga gaagaagata 2100aaagtgatcc tcaaagtctt agaccccagc cacagggata tttccctggc cttcttcgag 2160gcagccagca tgatgagaca ggtctcccac aaacacatcg tgtacctcta tggcgtctgt 2220gtccgcgacg tggagaatat catggtggaa gagtttgtgg aagggggtcc tctggatctc 2280ttcatgcacc ggaaaagcga tgtccttacc acaccatgga aattcaaagt tgccaaacag 2340ctggccagtg ccctgagcta cttggaggat aaagacctgg tccatggaaa tgtgtgtact 2400aaaaacctcc tcctggcccg tgagggcatc gacagtgagt gtggcccatt catcaagctc 2460agtgaccccg gcatccccat tacggtgctg tctaggcaag aatgcattga acgaatccca 2520tggattgctc ctgagtgtgt tgaggactcc aagaacctga gtgtggctgc tgacaagtgg 2580agctttggaa ccacgctctg ggaaatctgc tacaatggcg agatcccctt gaaagacaag 2640acgctgattg agaaagagag attctatgaa agccggtgca ggccagtgac accatcatgt 2700aaggagctgg ctgacctcat gacccgctgc atgaactatg accccaatca gaggcctttc 2760ttccgagcca tcatgagaga cattaataag cttgaagagc agaatccaga tattgtttca 2820gaaaaaaaac cagcaactga agtggacccc acacattttg aaaagcgctt cctaaagagg 2880atccgtgact tgggagaggg ccactttggg aaggttgagc tctgcaggta tgaccccgaa 2940ggggacaata caggggagca ggtggctgtt aaatctctga agcctgagag tggaggtaac 3000cacatagctg atctgaaaaa ggaaatcgag atcttaagga acctctatca tgagaacatt 3060gtgaagtaca aaggaatctg cacagaagac ggaggaaatg gtattaagct catcatggaa 3120tttctgcctt cgggaagcct taaggaatat cttccaaaga ataagaacaa aataaacctc 3180aaacagcagc taaaatatgc cgttcagatt tgtaagggga tggactattt gggttctcgg 3240caatacgttc accgggactt ggcagcaaga aatgtccttg ttgagagtga acaccaagtg 3300aaaattggag acttcggttt aaccaaagca attgaaaccg ataaggagta ttacaccgtc 3360aaggatgacc gggacagccc tgtgttttgg tatgctccag aatgtttaat gcaatctaaa 3420ttttatattg cctctgacgt ctggtctttt ggagtcactc tgcatgagct gctgacttac 3480tgtgattcag attctagtcc catggctttg ttcctgaaaa tgataggccc aacccatggc 3540cagatgacag tcacaagact tgtgaatacg ttaaaagaag gaaaacgcct gccgtgccca 3600cctaactgtc cagatgaggt ttatcaactt atgaggaaat gctgggaatt ccaaccatcc 3660aatcggacaa gctttcagaa ccttattgaa ggatttgaag cacttttaaa ataagaagca 3720tgaataacat ttaaattcca cagattatca agtccttctc ctgcaacaaa tgcccaagtc 3780attttttaaa aatttctaat gaaagaagtt tgtgttctgt ccaaaaagtc actgaactca 3840tacttcagta catatacatg tataaggcac actgtagtgc ttaatatgtg taaggacttc 3900ctctttaaat ttggtaccag taacttagtg acacataatg acaaccaaaa tatttgaaag 3960cacttaagca ctcctccttg tggaaagaat ataccaccat ttcatctggc tagttcacca 4020tcacaactgc attaccaaaa ggggattttt gaaaacgagg agttgaccaa aataatatct 4080gaagatgatt gcttttccct gctgccagct gatctgaaat gttttgctgg cacattaatc 4140atagataaag aaagattgat ggacttagcc ctcaaatttc agtatctata cagtactaga 4200ccatgcattc ttaaaatatt agataccagg tagtatatat tgtttctgta caaaaatgac 4260tgtattctct caccagtagg acttaaactt tgtttctcca gtggcttagc tcctgttcct 4320ttgggtgatc actagcaccc atttttgaga aagctggttc tacatggggg gatagctgtg 4380gaatagataa tttgctgcat gttaattctc aagaactaag cctgtgccag tgctttccta 4440agcagtatac ctttaatcag aactcattcc cagaacctgg atgctattac acatgctttt 4500aagaaacgtc aatgtatatc cttttataac tctaccactt tggggcaagc tattccagca 4560ctggttttga atgctgtatg caaccagtct gaataccaca tacgctgcac tgttcttaga 4620gggtttccat acttaccacc gatctacaag ggttgatccc tgtttttacc atcaatcatc 4680accctgtggt gcaacacttg aaagacccgg ctagaggcac tatggacttc aggatccact 4740agacagtttt cagtttgctt ggaggtagct gggtaatcaa aaatgtttag tcattgattc 4800aatgtgaacg attacggtct ttatgaccaa gagtctgaaa atctttttgt tatgctgttt 4860agtattcgtt tgatattgtt acttttcacc tgttgagccc aaattcagga ttggttcagt 4920ggcagcaatg aagttgccat ttaaatttgt tcatagccta catcaccaag gtctctgtgt 4980caaacctgtg gccactctat atgcactttg tttactcttt atacaaataa atatactaaa 5040gactttacat gca 5053721DNAartificialJAK1_Seq_Exon14F 7ctggcctgag acattcctat g 21826DNAartificialJAK1_ Seq_Exon14R 8tgaaagagaa cacacttact ctccac 26923DNAartificialJAK1_HRM_Exon14F 9gcatgatgag acaggtctcc cac 231024DNAartificialJAK1_HRM_Exon14R 10gagaacacac ttactctcca cgtc 241121DNAartificialJAK2_Seq_Exon12F 11cagcaagtat gatgagcaag c 211220DNAartificialJAK2_Seq_Exon12R 12acagatgctc tgagaaaggc 201320DNAartificialJAK2_HRM_Exon12F 13gctttctcac aagcatttgg 201420DNAartificialJAK2_HRM_Exon12R 14ggcattagaa agcctgtagt 201521DNAartificialJAK3_Seq_Exon12F 15gcaggtctgt gagcacaaaa t 211619DNAartificialJAK3_Seq_Exon12R 16actgtctcca gccatgcac

191719DNAartificialJAK3_HRM_Exon12F 17ccaccttccc cagtcattc 191821DNAartificialJAK3_HRM_Exon12R 18gagatgccgg tacgacactt g 21

Claims

1. A method for predicting Natural Killer T-Cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject, comprising testing for the genotype of said subject for at least one JAK gene or testing for whether said subject expresses a wildtype or mutant JAK protein, wherein the presence of a mutant JAK gene indicates that a subject is at risk of developing and/or has NKTCL.

2. The method according to claim 1, wherein: when the method comprises testing for the genotype of said subject for at least one JAK gene, the method comprises testing for the genotype of said subject for at least one of JAK1, JAK2, JAK3 and/or TYK2 genes; and when the method comprises testing for whether said subject expresses a wildtype or mutant JAK protein, the method comprises testing for whether said subject expresses wildtype and/or at least one mutant JAK1, JAK2, JAK3 and/or TYK2 protein.

3. (canceled)

4. The method according to claim 1, wherein: a wildtype JAK3 gene comprises SEQ ID NO: 1 and the mutant JAK3 gene comprises a substitution of C with T at nucleotide 15792 and/or a substitution of C with T at nucleotide 15795 of SEQ ID NO: 1; and/or a wildtype JAK1 gene comprises SEQ ID NO: 3 and the mutant gene comprises a substitution of T with G at nucleotide 124823 of SEQ ID NO:3.

5. (canceled)

6. The method according to claim 1, further comprising providing an isolated blood and/or cell sample from the subject for said testing.

7. The method according to claim 6, wherein when the method comprises testing for the genotype of said subject for at least one JAK gene, the method further comprises isolating nucleic acid molecules from the subject for said testing; and when the method comprises testing for whether said subject expresses a wildtype or mutant JAK protein, the method further comprises isolating at least one protein from the subject for said testing.

8. (canceled)

9. The method according to claim 1, wherein when the method comprises testing for the genotype of said subject for at least one JAK gene, said testing is performed on genomic DNA, mRNA and/or cDNA; and/or said testing comprises sequence analysis, restriction fragment length polymorphism analysis, hybridization, polymerase chain reaction (PCR), or reverse transcription PCR

10-17. (canceled)

18. The method according to claim 1, wherein when the method comprises testing for whether said subject expresses a wildtype or mutant JAK protein, the testing comprises protein sequencing and antibody detection methods.

19. A method for screening for an agent capable of treating NKTCL, or for an agent capable of reducing the activity of at least one JAK protein, the method comprising: (i) providing a NKTCL cell line comprising at least one mutant JAK gene; (ii) contacting the NKTCL cell line with the agent; and (iii) determining the effect of the agent on the mammalian NKTCL cell line; wherein the ability of the agent to reduce the viability, growth and/or multiplication and/or increase apoptosis of the NKTCL cell line is indicative of the ability of the agent to treat NKTCL, or to reduce the activity of at least one JAK protein.

20. (canceled)

21. The method according to claim 19, wherein the NKTCL cell line carries at least one of mutant JAK1, JAK2, JAK3 and/or TYK2 genes.

22. (canceled)

23. The method according to claim 19, wherein the NKTCL cell line carries at least one of the following JAK mutations: (i) a substitution of C with Tat nucleotide 15792 of SEQ ID NO: 1; (ii) a substitution of C with Tat nucleotide 15795 of SEQ ID NO: 1; and (iii) a substitution of T with G at nucleotide 124823 of SEQ ID NO: 3.

24. An NKTCL animal model comprising at least one mutant JAK gene.

25. The NKTCL animal model according to claim 24, comprising at least one of mutant JAK1, JAK2, JAK3 and/or TYK2 genes.

26. (canceled)

27. The NKTCL animal model according to claim 24, comprising at least one of the following mutations: (i) a substitution of C with Tat nucleotide 15792 of SEQ ID NO: 1; (ii) a substitution of C with Tat nucleotide 15795 of SEQ ID NO: 1; or (iii) a substitution of T with G at nucleotide 124823 of SEQ ID NO: 3.

28. A method of treating Natural Killer T-Cell Lymphoma (NKTCL) comprising administering at least one JAK inhibitor to a subject.

29. The method according to claim 28, wherein the JAK inhibitor inhibits at least one of JAK1, JAK2, JAK3 and/or TYK2 proteins.

30-32. (canceled)

33. The method according to claim 28, wherein the JAK inhibitor comprises 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piper- idin-1-yl]-3-oxopropanenitrile (CP-690,550) and/or (E)-2-cyano-3-(4-nitrophenyl)-N-((R)-1-phenylethyl)acrylamide (WP-1034).

34-35. (canceled)

36. The method according to claim 28, wherein the subject comprises a mammal.

37. (canceled)

38. The method according to claim 28, wherein the subject with at least one mutation selected from the group consisting of JAK3-A572V, JAK3-A573V and/or JAK1-Y652D.

39-56. (canceled)

57. The method according to claim 1, wherein: the wildtype JAK3 protein comprises SEQ ID NO:2 and the mutant JAK3 protein comprises a substitution of A with V at amino acid 572 and/or a substitution of A with V at amino acid 573 of SEQ ID NO:2; and/or the wildtype JAK1 protein comprises SEQ ID NO: 4 and the mutant JAK1 protein comprises a substitution of Y with D at amino acid 652 of SEQ ID NO:4.