U.S. patent application number 14/730263 was filed with the patent office on 2015-09-24 for perfume systems.
The applicant listed for this patent is The Proctor & Gamble Company. Invention is credited to Hugo Robert Germain DENUTTE, An PINTENS, Johan SMETS, Koen VAN AKEN, Freek Annie Camiel VRIELYNCK.
Application Number | 20150267143 14/730263 |
Document ID | / |
Family ID | 49911789 |
Filed Date | 2015-09-24 |
United States Patent
Application |
20150267143 |
Kind Code |
A1 |
DENUTTE; Hugo Robert Germain ;
et al. |
September 24, 2015 |
PERFUME SYSTEMS
Abstract
The present application relates to perfume raw materials,
perfume delivery systems and consumer products comprising such
perfume raw materials and/or such perfume delivery systems, as well
as processes for making and using such perfume raw materials,
perfume delivery systems and consumer products. Such perfume raw
materials and compositions, including the delivery systems,
disclosed herein expand the perfume communities' options as such
perfume raw materials can provide variations on character and such
compositions can provide desired odor profiles.
Inventors: |
DENUTTE; Hugo Robert Germain;
(Hofstade (Aalst), BE) ; PINTENS; An; (Brasschaat,
BE) ; SMETS; Johan; (Lubbeek, BE) ; VRIELYNCK;
Freek Annie Camiel; (Beernem, BE) ; VAN AKEN;
Koen; (Kuurne, BE) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
The Proctor & Gamble Company |
Cincinnati |
OH |
US |
|
|
Family ID: |
49911789 |
Appl. No.: |
14/730263 |
Filed: |
June 4, 2015 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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14096041 |
Dec 4, 2013 |
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14730263 |
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61734011 |
Dec 6, 2012 |
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Current U.S.
Class: |
424/49 ; 510/103;
512/13; 512/4; 549/397; 549/463 |
Current CPC
Class: |
A61Q 11/00 20130101;
C11D 3/2096 20130101; A61K 8/498 20130101; C07D 493/08 20130101;
A61Q 13/00 20130101; C11D 11/0017 20130101; C11D 3/505 20130101;
A61Q 5/02 20130101; C11B 9/008 20130101; A61K 8/4973 20130101; C11B
9/0076 20130101 |
International
Class: |
C11B 9/00 20060101
C11B009/00; C11D 11/00 20060101 C11D011/00; C11D 3/20 20060101
C11D003/20; A61K 8/49 20060101 A61K008/49; A61Q 11/00 20060101
A61Q011/00; C11D 3/50 20060101 C11D003/50 |
Claims
1. A molecule selected from the group consisting of: a) a molecule
having the following structure ##STR00035## R.sub.1, R.sub.2,
R.sub.3 and R.sub.4 are each independently selected from the group
consisting of: hydrogen; a straight or branched C.sub.1-C.sub.6
alkyl moiety; a straight or branched C.sub.2-C.sub.6 alkenyl
moiety; and a straight or branched C.sub.2-C.sub.6 alkyne moiety;
and R.sub.5 is selected from the group consisting of a straight or
branched C.sub.1-C.sub.6 alkyl moiety; a straight or branched
C.sub.2-C.sub.6 alkenyl moiety; and a straight or branched
C.sub.2-C.sub.6 alkyne moiety; b) stereomers of said molecule; and
c) mixtures thereof.
2. A composition comprising, based on total composition weight, at
least 0.00001% of one or more molecules according to claim 1 and an
optional adjunct material.
3. A composition according to claim 2, said composition comprising
based on total composition weight, from about 0.0001% to about 25%
of one or more molecules according to claim 1; and an adjunct
ingredient said composition being a consumer product.
4. A composition according to claim 2, said composition, being a
cleaning and treatment composition.
5. A composition according to claim 2, said composition being a
fabric and/or hard surface cleaning and/or treatment
composition.
6. A composition according to claim 2, said composition being a
detergent, said detergent comprising, based on total detergent
weight, from about 0.00001% to about 25% of one or more molecules
according to claim 1; and an adjunct ingredient.
7. A composition according to claim 2, said composition being a
highly compacted consumer product, said highly compacted consumer
product comprising, based on total highly compacted consumer
product weight, from about 0.00001% to about 25% of one or more
molecules according to claim 1; and an adjunct ingredient.
8. A highly compacted consumer product according to claim 7, said
highly compacted consumer product being a highly compacted
detergent.
9. The composition of claim 2, said composition being a perfume
delivery system selected from a polymer assisted delivery system; a
molecule-assisted delivery system; a fiber-assisted delivery
system; a cyclodextrin delivery system; a starch encapsulated
accord; and/or an inorganic carrier delivery system.
10. A perfume delivery system according to claim 9, said perfume
delivery system being a nanocapsule or a microcapsule comprising,
based on total nanocapsule or microcapsule weight, at least 0.001%
of one or more molecules according to claim 1.
11. A perfume delivery system according to claim 9, said perfume
delivery system being a starch encapsulated accord comprising,
based on total starch encapsulate or starch agglomerate weight, at
least 0.001% of one or more molecules according to claim 1.
12. A perfume delivery system according to claim 9, said perfume
delivery system being a cyclodextrin delivery system comprising
based on total cyclodextrin delivery system weight, at least 0.001%
of one or more molecules according to claim 1.
13. A perfume delivery system according to claim 9, said perfume
delivery system being a polymer assisted delivery matrix system
comprising, based on total polymer assisted delivery matrix system
weight, at least 0.001% of one or more molecules according to claim
1.
14. A consumer product comprising, based on total consumer product
weight, at least 0.001% of a perfume delivery system selected from
the perfume delivery systems of claims 9-13 and mixtures
thereof.
15. An oral care composition comprising, based on total composition
weight, at least 0.001% of one or more molecules according to claim
1 and an adjunct ingredient selected from the group consisting of
stannous, zinc, potassium, calcium, or copper salts, antibacterial
agents, anti-tartar agents, breath reduction agents, chelants,
structuring agents, TRPV1 or TRPA1 agonists, TRPV1 or TRPA1
antagonists, TRPM8 enhancers, flavor, tooth sensitivity actives,
caries actives, abrasives, sorbitol, menthol, bitter blockers,
anionic surfactant, cationic surfactant, nonionic surfactant, or
combinations thereof.
Description
FIELD OF INVENTION
[0001] The present application relates to perfume raw materials,
perfume delivery systems and consumer products comprising such
perfume raw materials and/or perfume delivery systems, as well as
processes for making and using such perfume raw materials, perfume
delivery systems and consumer products.
BACKGROUND OF THE INVENTION
[0002] Consumer products may comprise one or more perfumes, and/or
perfume delivery systems that can mask an undesirable odor and/or
provide a desired scent and/or experience to a product and/or a
situs that is contacted with such a product. While current
perfumes, and perfume delivery systems provide desirable
experiences and/or fragrances, consumers continue to seek products
that contain sensates, such as cooling or have scents that may be
longer lasting and that are tailored to their individual desires
(see for example USPA 2007/0275866 A1 and USPA 2008/0305977
A1)--unfortunately the pool of perfume raw materials and perfume
delivery systems that is available is still too limited to
completely meet the desired needs.
[0003] Applicants believe that the perfume raw materials and
perfumes, including the delivery systems, disclosed herein expand
the options, as such sensates and/or perfume raw materials can
provide variations on character and such and/or perfumes can
provide desired sensations and/or odor profiles. In certain
aspects, such and/or perfume raw materials and/or perfume delivery
systems comprising such and/or perfume raw materials may provide
variations on character, sensation and/or odor profiles that are
better than expected as measured by parameters such as headspace
analysis (employed to determine perfume delivery system perfume
leakage and/or perfume delivery efficiency), C log P, boiling point
and/or odor detection threshold.
SUMMARY OF THE INVENTION
[0004] The present application relates to perfume raw materials,
perfume delivery systems and consumer products comprising such
perfume raw materials and/or such perfume delivery systems, as well
as processes for making and using such perfume raw materials,
perfume delivery systems and consumer products.
DETAILED DESCRIPTION OF THE INVENTION
Definitions
[0005] As used herein "consumer product" means baby care, beauty
care, fabric & home care, family care, feminine care, health
care, snack and/or beverage products or devices generally intended
to be used or consumed in the form in which it is sold. Such
products include but are not limited to diapers, bibs, wipes;
products for and/or methods relating to treating hair (human, dog,
and/or cat), including, bleaching, coloring, dyeing, conditioning,
shampooing, styling; deodorants and antiperspirants; personal
cleansing; cosmetics; skin care including application of creams,
lotions, and other topically applied products for consumer use
including fine fragrances; and shaving products, products for
and/or methods relating to treating fabrics, hard surfaces and any
other surfaces in the area of fabric and home care, including: air
care including air fresheners and scent delivery systems, car care,
dishwashing, fabric conditioning (including softening and/or
freshening), laundry detergency, laundry and rinse additive and/or
care, hard surface cleaning and/or treatment including floor and
toilet bowl cleaners, and other cleaning for consumer or
institutional use; products and/or methods relating to bath tissue,
facial tissue, paper handkerchiefs, and/or paper towels; tampons,
feminine napkins; products and/or methods relating to oral care
including toothpastes, tooth gels, tooth rinses, denture adhesives,
tooth whitening; over-the-counter health care including cough and
cold remedies, pain relievers, RX pharmaceuticals, pet health and
nutrition; processed food products intended primarily for
consumption between customary meals or as a meal accompaniment
(non-limiting examples include potato chips, tortilla chips,
popcorn, pretzels, corn chips, cereal bars, vegetable chips or
crisps, snack mixes, party mixes, multigrain chips, snack crackers,
cheese snacks, pork rinds, corn snacks, pellet snacks, extruded
snacks and bagel chips); and coffee.
[0006] As used herein, the term "cleaning and/or treatment
composition" is a subset of consumer products that includes, unless
otherwise indicated, beauty care, fabric & home care products.
Such products include, but are not limited to, products for
treating hair (human, dog, and/or cat), including, bleaching,
coloring, dyeing, conditioning, shampooing, styling; deodorants and
antiperspirants; personal cleansing; cosmetics; skin care including
application of creams, lotions, and other topically applied
products for consumer use including fine fragrances; and shaving
products, products for treating fabrics, hard surfaces and any
other surfaces in the area of fabric and home care, including: air
care including air fresheners and scent delivery systems, car care,
dishwashing, fabric conditioning (including softening and/or
freshening), laundry detergency, laundry and rinse additive and/or
care, hard surface cleaning and/or treatment including floor and
toilet bowl cleaners, granular or powder-form all-purpose or
"heavy-duty" washing agents, especially cleaning detergents;
liquid, gel or paste-form all-purpose washing agents, especially
the so-called heavy-duty liquid types; liquid fine-fabric
detergents; hand dishwashing agents or light duty dishwashing
agents, especially those of the high-foaming type; machine
dishwashing agents, including the various tablet, granular, liquid
and rinse-aid types for household and institutional use; liquid
cleaning and disinfecting agents, including antibacterial hand-wash
types, cleaning bars, mouthwashes, denture cleaners, dentifrice,
car or carpet shampoos, bathroom cleaners including toilet bowl
cleaners; hair shampoos and hair-rinses; shower gels, fine
fragrances and foam baths and metal cleaners; as well as cleaning
auxiliaries such as bleach additives and "stain-stick" or pre-treat
types, substrate-laden products such as dryer added sheets, dry and
wetted wipes and pads, nonwoven substrates, and sponges; as well as
sprays and mists all for consumer or/and institutional use; and/or
methods relating to oral care including toothpastes, tooth gels,
tooth rinses, denture adhesives, tooth whitening.
[0007] As used herein, the term "fabric and/or hard surface
cleaning and/or treatment composition" is a subset of cleaning and
treatment compositions that includes, unless otherwise indicated,
granular or powder-form all-purpose or "heavy-duty" washing agents,
especially cleaning detergents; liquid, gel or paste-form
all-purpose washing agents, especially the so-called heavy-duty
liquid types; liquid fine-fabric detergents; hand dishwashing
agents or light duty dishwashing agents, especially those of the
high-foaming type; machine dishwashing agents, including the
various tablet, granular, liquid and rinse-aid types for household
and institutional use; liquid cleaning and disinfecting agents,
including antibacterial hand-wash types, cleaning bars, car or
carpet shampoos, bathroom cleaners including toilet bowl cleaners;
and metal cleaners, fabric conditioning products including
softening and/or freshening that may be in liquid, solid and/or
dryer sheet form; as well as cleaning auxiliaries such as bleach
additives and "stain-stick" or pre-treat types, substrate-laden
products such as dryer added sheets, dry and wetted wipes and pads,
nonwoven substrates, and sponges; as well as sprays and mists. All
of such products which were applicable may be in standard,
concentrated or even highly concentrated form even to the extent
that such products may in certain aspect be non-aqueous.
[0008] As used herein, the term "oral care composition" is a
product, which in the ordinary course of usage, is not
intentionally swallowed for purposes of systemic administration of
particular therapeutic agents, but is rather retained in the oral
cavity for a time sufficient to contact substantially all of the
dental surfaces and/or oral tissues for purposes of oral activity.
The oral care composition may be in various forms including
toothpaste, dentifrice, tooth gel, subgingival gel, mouthrinse,
mousse, foam, mouthspray, lozenge, chewable tablet, chewing gum or
denture product. The oral care composition may also be incorporated
onto strips or films for direct application or attachment to oral
surfaces. The term "dentifrice", as used herein, includes paste,
gel, or liquid formulations unless otherwise specified.
[0009] The dentifrice composition may be a single phase composition
or may be a combination of two or more separate dentifrice
compositions. The dentifrice composition may be in any desired
form, such as deep striped, surface striped, multilayered,having a
gel surrounding a paste, or any combination thereof. Each
dentifrice composition in a dentifrice comprising two or more
separate dentifrice compositions may be contained in a physically
separated compartment of a dispenser and dispensed
side-by-side.
[0010] As used herein, articles such as "a" and "an" when used in a
claim, are understood to mean one or more of what is claimed or
described.
[0011] As used herein, the terms "include", "includes" and
"including" are meant to be non-limiting.
[0012] As used herein, the term "solid" includes granular, powder,
bar and tablet product forms.
[0013] As used herein, the term "fluid" includes liquid, gel, paste
and gas product forms.
[0014] As used herein, the term "situs" includes paper products,
fabrics, garments, hard surfaces, hair and skin.
[0015] As used herein, "perfume raw materials" include molecules
that can serve the purposes of providing odour and/or a sensation
such as cooling.
[0016] Unless otherwise noted, all component or composition levels
are in reference to the active portion of that component or
composition, and are exclusive of impurities, for example, residual
solvents or by-products, which may be present in commercially
available sources of such components or compositions.
[0017] All percentages and ratios are calculated by weight unless
otherwise indicated. All percentages and ratios are calculated
based on the total composition unless otherwise indicated.
[0018] It should be understood that every maximum numerical
limitation given throughout this specification includes every lower
numerical limitation, as if such lower numerical limitations were
expressly written herein. Every minimum numerical limitation given
throughout this specification will include every higher numerical
limitation, as if such higher numerical limitations were expressly
written herein. Every numerical range given throughout this
specification will include every narrower numerical range that
falls within such broader numerical range, as if such narrower
numerical ranges were all expressly written herein.
[0019] The PRMs disclosed herein (a.k.a., molecules) may provide
one or more of the following benefits at levels that Applicants
believe are unexpected in view of PRMs in general: a cooling
sensation, neat product odor; wet fabric odor when applied to a
fabric; dry fabric odor when applied to a fabric; reduced leakage
from an encapsulate, including an encapsulate such as a perfume
microcapsule; increased head space versus neat oil in certain
perfume delivery technologies; odor when used in a matrix perfume
delivery that is applied to a package; neat product odor when
applied to a cleaning and/or treatment composition; fine fragrance
composition odor when used in a fine fragrance; dry hair odor when
a composition comprising such a PRM is applied to hair; PRM bloom
from a solution comprising such a PRM; and new PRM character when
applied to a situs. Confirmation of such benefits can be obtained
by applying standard test methodologies detailed herein. The PRMs
and stereoisomers of such PRMs above can be made in accordance with
the teachings detailed in the present specification.
[0020] Molecules having Structure 1 or Structure 2 below and
stereoisomers of such molecules are disclosed.
##STR00001##
For Structure 1:
[0021] R.sub.1, R.sub.4 and R.sub.5 are each independently selected
from the group consisting of: a straight or branched
C.sub.1-C.sub.6 alkyl moiety; a straight or branched
C.sub.2-C.sub.6 alkenyl moiety; and a straight or branched
C.sub.2-C.sub.6 alkyne moiety; and [0022] R.sub.2 and R.sub.3 are
each independently selected from the group consisting of: hydrogen;
a straight or branched C.sub.1-C.sub.6 alkyl moiety; a straight or
branched C.sub.2-C.sub.6 alkenyl moiety; and a straight or branched
C.sub.2-C.sub.6 alkyne moiety.
For Structure 2:
[0022] [0023] R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each
independently selected from the group consisting of: hydrogen; a
straight or branched C.sub.1-C.sub.6 alkyl moiety; a straight or
branched C.sub.2-C.sub.6 alkenyl moiety; and a straight or branched
C.sub.2-C.sub.6 alkyne moiety; [0024] and R.sub.5 is selected from
the group consisting of a straight or branched C.sub.1-C.sub.6
alkyl moiety; a straight or branched C.sub.2-C.sub.6 alkenyl
moiety; and a straight or branched C.sub.2-C.sub.6 alkyne
moiety.
[0025] In one aspect, a composition comprising, based on total
composition weight, at least 0.00001%, from about 0.001% to about
95%, from about 0.01% to about 85%, from about 0.01% to about 75%,
from about 0.01% to about 65%, from about 0.01% to about 50%, from
about 0.1% to about 15%, from about 0.1% to about 10% or even from
about 0.5% to about 10% of one or more molecules having a structure
according to Structure 1 and/or Structure 2 and an optional adjunct
material is disclosed.
[0026] In one aspect, said composition comprises, based on total
composition weight, at least 0.001%, from about 0.001% to about 5%,
from 0.005% to about 4%, or even from 0.010% to about 2% of one or
more molecules having a structure according to Structure 1 and/or
Structure 2 and an adjunct ingredient selected from the group
consisting of stannous, zinc, potassium, calcium, or copper salts,
antibacterial agents, anti-tartar agents, breath reduction agents,
chelants, structuring agents, TRPV1 or TRPA1 agonists, TRPV1 or
TRPA1 antagonists, TRPM8 enhancers, flavor, tooth sensitivity
actives, caries actives, abrasives, sorbitol, menthol, bitter
blockers, anionic surfactant, cationic surfactant, nonionic
surfactant, or combinations thereof is disclosed. Said composition
can be used as an oral care composition.
[0027] In one aspect, said composition, is a cleaning and treatment
composition.
[0028] In one aspect, said composition is a fabric and/or hard
surface cleaning and/or treatment composition.
[0029] In one aspect, said composition is a detergent that
comprises, based on total detergent weight, from about 0.00001% to
about 25%, from 0.00005% to about 10%, from 0.0001% to about 5%,
from 0.0005% to about 1.0%, or even from 0.001% to about 0.5% of
one or more molecules according to claim 1; and an adjunct
ingredient.
[0030] In one aspect, said composition is highly compacted consumer
product, said highly compacted consumer product that comprises,
based on total highly compacted consumer product weight, from about
0.00001% to about 25%, from 0.00005% to about 10%, from 0.0001% to
about 5%, from 0.0005% to about 1.0%, or even from 0.001% to about
0.5% of one or more molecules having a structure according to
Structure 1 and/or Structure 2; and an adjunct ingredient.
[0031] In one aspect, said composition is highly compacted consumer
product is a highly compacted detergent.
[0032] In one aspect, said composition comprises, based on total
composition weight, from about 0.0001% to about 25%, from about
0.0005% to about 10%, from about 0.001% to about 5%, from about
0.005% to about 2.5%, or even from 0.01% to about 1% of one or more
molecules having a structure according to Structure 1 and/or
Structure 2; and an adjunct ingredient said composition being a
consumer product.
Perfume Delivery Systems
[0033] In one aspect, a perfume delivery system comprising, based
on total composition weight, at least 0.00001%, from about 0.001%
to about 95%, from about 0.01% to about 85%, from about 0.01% to
about 75%, from about 0.01% to about 65%, from about 0.01% to about
50%, from about 0.1% to about 15%, from about 0.1% to about 10% or
even from about 0.5% to about 10% of one or more molecules having a
structure according to Structure 1 and/or Structure 2 and an
optional adjunct material, said perfume delivery system being a
perfume delivery system selected from a polymer assisted delivery
system; a molecule-assisted delivery system; a fiber-assisted
delivery system; a cyclodextrin delivery system; a starch
encapsulated accord; and/or an inorganic carrier delivery system is
disclosed.
[0034] In one aspect, said perfume delivery system is a nanocapsule
or a microcapsule comprising, based on total nanocapsule or
microcapsule weight, at least 0.001%, from about 0.1% to about 99%,
from 25% to about 95%, from 30 to about 90%, from 45% to about 90%,
or from 65% to about 90% of one or more molecules having a
structure according to Structure 1 and/or Structure 2.
[0035] In one aspect, said perfume delivery system being a starch
encapsulated accord comprising, based on total starch encapsulate
or starch agglomerate weight, at least 0.001%, from about 0.1% to
about 99%, from 25% to about 95%, from 30 to about 90%, from 45% to
about 90%, from 65% to about 90% of one or more molecules having a
structure according to Structure 1 and/or Structure 2.
[0036] In one aspect, said perfume delivery system being a
cyclodextrin delivery system comprising based on total cyclodextrin
delivery system weight, at least 0.001%, from 0.1% to about 99%,
from 2.5% to about 75%, from 5% to about 60%, from 5% to about 50%,
from 5% to about 25% of one or more molecules having a structure
according to Structure 1 and/or Structure 2.
[0037] In one aspect, said perfume delivery system being a polymer
assisted delivery matrix system comprising, based on total polymer
assisted delivery matrix system weight, at least 0.001%, from 0.1%
to about 99%, from 2.5% to about 75%, from 5% to about 60%, from 5%
to about 50%, from 5% to about 25% of one or more molecules having
a structure according to Structure 1 and/or Structure 2.
[0038] In one aspect, a consumer product comprising, based on total
consumer product weight, at least 0.001%, from about 0.001% to
about 20%, from about 0.01% to about 10%, from about 0.05% to about
5%, from about 0.1% to about 0.5% of a perfume delivery system
selected from the perfume delivery systems disclosed herein and
mixtures thereof is disclosed.
[0039] Certain perfume delivery systems, methods of making certain
perfume delivery systems and the uses of such perfume delivery
systems are disclosed in USPA 2007/0275866 A1. Such perfume
delivery systems include: [0040] I. Polymer Assisted Delivery
(PAD): This perfume delivery technology uses polymeric materials to
deliver perfume materials. Classical coacervation, water soluble or
partly soluble to insoluble charged or neutral polymers, liquid
crystals, hot melts, hydrogels, perfumed plastics, microcapsules,
nano- and micro-latexes, polymeric film formers, and polymeric
absorbents, polymeric adsorbents, etc. are some examples. PAD
includes but is not limited to:
[0041] a.) Matrix Systems: The fragrance is dissolved or dispersed
in a polymer matrix or particle. Perfumes, for example, may be 1)
dispersed into the polymer prior to formulating into the product or
2) added separately from the polymer during or after formulation of
the product. Diffusion of perfume from the polymer is a common
trigger that allows or increases the rate of perfume release from a
polymeric matrix system that is deposited or applied to the desired
surface (situs), although many other triggers are know that may
control perfume release. Absorption and/or adsorption into or onto
polymeric particles, films, solutions, and the like are aspects of
this technology. Nano- or micro-particles composed of organic
materials (e.g., latexes) are examples. Suitable particles include
a wide range of materials including, but not limited to polyacetal,
polyacrylate, polyacrylic, polyacrylonitrile, polyamide,
polyaryletherketone, polybutadiene, polybutylene, polybutylene
terephthalate, polychloroprene, poly ethylene, polyethylene
terephthalate, polycyclohexylene dimethylene terephthalate,
polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone,
polyester, polyethylene, polyetherimide, polyethersulfone,
polyethylenechlorinates, polyimide, polyisoprene, polylactic acid,
polymethylpentene, polyphenylene oxide, polyphenylene sulfide,
polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl
acetate, polyvinyl chloride, as well as polymers or copolymers
based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl
acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl
acetate-ethylene, and mixtures thereof.
[0042] "Standard" systems refer to those that are "pre-loaded" with
the intent of keeping the pre-loaded perfume associated with the
polymer until the moment or moments of perfume release. Such
polymers may also suppress the neat product odor and provide a
bloom and/or longevity benefit depending on the rate of perfume
release. One challenge with such systems is to achieve the ideal
balance between 1) in-product stability (keeping perfume inside
carrier until you need it) and 2) timely release (during use or
from dry situs). Achieving such stability is particularly important
during in-product storage and product aging. This challenge is
particularly apparent for aqueous-based, surfactant-containing
products, such as heavy duty liquid laundry detergents. Many
"Standard" matrix systems available effectively become
"Equilibrium" systems when formulated into aqueous-based products.
One may select an "Equilibrium" system or a Reservoir system, which
has acceptable in-product diffusion stability and available
triggers for release (e.g., friction). "Equilibrium" systems are
those in which the perfume and polymer may be added separately to
the product, and the equilibrium interaction between perfume and
polymer leads to a benefit at one or more consumer touch points
(versus a free perfume control that has no polymer-assisted
delivery technology). The polymer may also be pre-loaded with
perfume; however, part or all of the perfume may diffuse during
in-product storage reaching an equilibrium that includes having
desired perfume raw materials (PRMs) associated with the polymer.
The polymer then carries the perfume to the surface, and release is
typically via perfume diffusion. The use of such equilibrium system
polymers has the potential to decrease the neat product odor
intensity of the neat product (usually more so in the case of
pre-loaded standard system). Deposition of such polymers may serve
to "flatten" the release profile and provide increased longevity.
As indicated above, such longevity would be achieved by suppressing
the initial intensity and may enable the formulator to use more
high impact or low odor detection threshold (ODT) or low Kovats
Index (KI) PRMs to achieve FMOT benefits without initial intensity
that is too strong or distorted. It is important that perfume
release occurs within the time frame of the application to impact
the desired consumer touch point or touch points. Suitable
micro-particles and micro-latexes as well as methods of making same
may be found in USPA 2005/0003980 A1. Matrix systems also include
hot melt adhesives and perfume plastics. In addition,
hydrophobically modified polysaccharides may be formulated into the
perfumed product to increase perfume deposition and/or modify
perfume release. All such matrix systems, including for example
polysaccarides and nanolatexes may be combined with other PDTs,
including other PAD systems such as PAD reservoir systems in the
form of a perfume microcapsule (PMC). Polymer Assisted Delivery
(PAD) matrix systems may include those described in US Patent
Applications 2004/0110648 A1.
[0043] Silicones are also examples of polymers that may be used as
PDT, and can provide perfume benefits in a manner similar to the
polymer-assisted delivery "matrix system". Such a PDT is referred
to as silicone-assisted delivery (SAD). One may pre-load silicones
with perfume, or use them as an equilibrium system as described for
PAD. Functionalized silicones may also be used. Examples of
silicones include polydimethylsiloxane and
polyalkyldimethylsiloxanes. Other examples include those with amine
functionality, which may be used to provide benefits associated
with amine-assisted delivery (AAD) and/or polymer-assisted delivery
(PAD) and/or amine-reaction products (ARP). [0044] b.) Reservoir
Systems: Reservoir systems are also known as a core-shell type
technology, or one in which the fragrance is surrounded by a
perfume release controlling membrane, which may serve as a
protective shell. The material inside the microcapsule is referred
to as the core, internal phase, or fill, whereas the wall is
sometimes called a shell, coating, or membrane. Microparticles or
pressure sensitive capsules or microcapsules are examples of this
technology. Microcapsules of the current invention are formed by a
variety of procedures that include, but are not limited to,
coating, extrusion, spray-drying, interfacial, in-situ and matrix
polymerization. The possible shell materials vary widely in their
stability toward water. Among the most stable are
polyoxymethyleneurea (PMU)-based materials, which may hold certain
PRMs for even long periods of time in aqueous solution (or
product). Such systems include but are not limited to
urea-formaldehyde and/or melamine-formaldehyde. Stable shell
materials include polyacrylate-based materials obtained as reaction
product of an oil soluble or dispersible amine with a
multifunctional acrylate or methacrylate monomer or oligomer, an
oil soluble acid and an initiator, in presence of an anionic
emulsifier comprising a water soluble or water dispersible acrylic
acid alkyl acid copolymer, an alkali or alkali salt. Gelatin-based
microcapsules may be prepared so that they dissolve quickly or
slowly in water, depending for example on the degree of
cross-linking. Many other capsule wall materials are available and
vary in the degree of perfume diffusion stability observed. Without
wishing to be bound by theory, the rate of release of perfume from
a capsule, for example, once deposited on a surface is typically in
reverse order of in-product perfume diffusion stability. As such,
urea-formaldehyde and melamine-formaldehyde microcapsules for
example, typically require a release mechanism other than, or in
addition to, diffusion for release, such as mechanical force (e.g.,
friction, pressure, shear stress) that serves to break the capsule
and increase the rate of perfume (fragrance) release. Other
triggers include melting, dissolution, hydrolysis or other chemical
reaction, electromagnetic radiation, and the like. The use of
pre-loaded microcapsules requires the proper ratio of in-product
stability and in-use and/or on-surface (on-situs) release, as well
as proper selection of PRMs. Microcapsules that are based on
urea-formaldehyde and/or melamine-formaldehyde are relatively
stable, especially in near neutral aqueous-based solutions. These
materials may require a friction trigger which may not be
applicable to all product applications. Other microcapsule
materials (e.g., gelatin) may be unstable in aqueous-based products
and may even provide reduced benefit (versus free perfume control)
when in-product aged. Scratch and sniff technologies are yet
another example of PAD. [0045] II. Molecule-Assisted Delivery
(MAD): Non-polymer materials or molecules may also serve to improve
the delivery of perfume. Without wishing to be bound by theory,
perfume may non-covalently interact with organic materials,
resulting in altered deposition and/or release. Non-limiting
examples of such organic materials include but are not limited to
hydrophobic materials such as organic oils, waxes, mineral oils,
petrolatum, fatty acids or esters, sugars, surfactants, liposomes
and even other perfume raw material (perfume oils), as well as
natural oils, including body and/or other soils. Perfume fixatives
are yet another example. In one aspect, non-polymeric materials or
molecules have a C Log P greater than about 2. Molecule-Assisted
Delivery (MAD) may also include those described in U.S. Pat. No.
7,119,060. [0046] III. Fiber-Assisted Delivery (FAD): The choice or
use of a situs itself may serve to improve the delivery of perfume.
In fact, the situs itself may be a perfume delivery technology. For
example, different fabric types such as cotton or polyester will
have different properties with respect to ability to attract and/or
retain and/or release perfume. The amount of perfume deposited on
or in fibers may be altered by the choice of fiber, and also by the
history or treatment of the fiber, as well as by any fiber coatings
or treatments. Fibers may be woven and non-woven as well as natural
or synthetic. Natural fibers include those produced by plants,
animals, and geological processes, and include but are not limited
to cellulose materials such as cotton, linen, hemp jute, flax,
ramie, and sisal, and fibers used to manufacture paper and cloth.
Fiber-Assisted Delivery may consist of the use of wood fiber, such
as thermomechanical pulp and bleached or unbleached kraft or
sulfite pulps. Animal fibers consist largely of particular
proteins, such as silk, sinew, catgut and hair (including wool).
Polymer fibers based on synthetic chemicals include but are not
limited to polyamide nylon, PET or PBT polyester,
phenol-formaldehyde (PF), polyvinyl alcohol fiber (PVOH), polyvinyl
chloride fiber (PVC), polyolefins (PP and PE), and acrylic
polymers. All such fibers may be pre-loaded with a perfume, and
then added to a product that may or may not contain free perfume
and/or one or more perfume delivery technologies. In one aspect,
the fibers may be added to a product prior to being loaded with a
perfume, and then loaded with a perfume by adding a perfume that
may diffuse into the fiber, to the product. Without wishing to be
bound by theory, the perfume may absorb onto or be adsorbed into
the fiber, for example, during product storage, and then be
released at one or more moments of truth or consumer touch points.
[0047] IV. Cyclodextrin Delivery System (CD): This technology
approach uses a cyclic oligosaccharide or cyclodextrin to improve
the delivery of perfume. Typically a perfume and cyclodextrin (CD)
complex is formed. Such complexes may be preformed, formed in-situ,
or formed on or in the situs. Without wishing to be bound by
theory, loss of water may serve to shift the equilibrium toward the
CD-Perfume complex, especially if other adjunct ingredients (e.g.,
surfactant) are not present at high concentration to compete with
the perfume for the cyclodextrin cavity. A bloom benefit may be
achieved if water exposure or an increase in moisture content
occurs at a later time point. In addition, cyclodextrin allows the
perfume formulator increased flexibility in selection of PRMs.
Cyclodextrin may be pre-loaded with perfume or added separately
from perfume to obtain the desired perfume stability, deposition or
release benefit. Suitable CDs as well as methods of making same may
be found in USPA 2005/0003980 A1. [0048] V. Starch Encapsulated
Accord (SEA): The use of a starch encapsulated accord (SEA)
technology allows one to modify the properties of the perfume, for
example, by converting a liquid perfume into a solid by adding
ingredients such as starch. The benefit includes increased perfume
retention during product storage, especially under non-aqueous
conditions. Upon exposure to moisture, a perfume bloom may be
triggered. Benefits at other moments of truth may also be achieved
because the starch allows the product formulator to select PRMs or
PRM concentrations that normally cannot be used without the
presence of SEA. Another technology example includes the use of
other organic and inorganic materials, such as silica to convert
perfume from liquid to solid. Suitable SEAs as well as methods of
making same may be found in U.S. Pat. No. 6,458,754 B1. [0049] VI.
Inorganic Carrier Delivery System (ZIC): This technology relates to
the use of porous zeolites or other inorganic materials to deliver
perfumes. Perfume-loaded zeolite may be used with or without
adjunct ingredients used for example to coat the perfume-loaded
zeolite (PLZ) to change its perfume release properties during
product storage or during use or from the dry situs. Suitable
zeolite and inorganic carriers as well as methods of making same
may be found in USPA 2005/0003980 A1. Silica is another form of
ZIC. Another example of a suitable inorganic carrier includes
inorganic tubules, where the perfume or other active material is
contained within the lumen of the nano- or micro-tubules. In one
aspect, the perfume-loaded inorganic tubule (or Perfume-Loaded
Tubule or PLT) is a mineral nano- or micro-tubule, such as
halloysite or mixtures of halloysite with other inorganic
materials, including other clays. The PLT technology may also
comprise additional ingredients on the inside and/or outside of the
tubule for the purpose of improving in-product diffusion stability,
deposition on the desired situs or for controlling the release rate
of the loaded perfume. Monomeric and/or polymeric materials,
including starch encapsulation, may be used to coat, plug, cap, or
otherwise encapsulate the PLT. Suitable PLT systems as well as
methods of making same may be found in U.S. Pat. No. 5,651,976.
[0050] In another aspect, the perfume delivery systems disclosed
herein are suitable for use in consumer products, cleaning and
treatment compositions, fabric and hard surface cleaning and/or
treatment compositions, detergents, and highly compacted consumer
products, including highly compacted fabric and hard surface
cleaning and/or treatment compositions (e.g., solid or fluid highly
compacted detergents) at levels, based on total consumer product
weight, from about 0.001% to about 20%, from about 0.01% to about
10%, from about 0.05% to about 5%, from about 0.1% to about
0.5%.
[0051] The perfume delivery technologies (a.k.a., perfume delivery
systems) that are disclosed in the present specification may be
used in any combination in any type of consumer product, cleaning
and/or treatment composition, fabric and hard surface cleaning
and/or treatment composition, detergent, and/or highly compact
detergent.
Perfumes
[0052] The molecules having a structure according to Structure 1
and/or Structure 2 may be used to formulate perfumes. Such perfumes
are combinations of molecules that may be employed, based on total
perfume weight, at levels of from about 0.01% to about 50%, from
about 0.1% to about 15%, from about 0.1% to about 10% or even from
about 0.5% to about 10%. Such perfumes may be utilized in various
applications, including being applied neat to a situs or used in a
consumer product, cleaning and/or treatment composition, fabric and
hard surface cleaning and/or treatment composition, detergent,
and/or a highly compact detergent.
Adjunct Materials
[0053] For the purposes of the present invention, the non-limiting
list of adjuncts illustrated hereinafter are suitable for use in
the compositions detailed herein (e.g., consumer products, cleaning
and/or treatment compositions, fabric and hard surface cleaning
and/or treatment compositions, detergents, and/or a highly compact
detergents). Such adjunct materials may be desirably incorporated
in certain embodiments of the compositions, for example to assist
or enhance performance of the composition, for treatment of the
substrate to be cleaned, or to modify the aesthetics of the
composition as is the case with perfumes, colorants, dyes or the
like. It is understood that such adjuncts are in addition to the
components that are supplied via Applicants' perfumes and/or
perfume systems detailed herein. The precise nature of these
additional components, and levels of incorporation thereof, will
depend on the physical form of the composition and the nature of
the operation for which it is to be used.
[0054] Suitable adjunct materials include, but are not limited to,
surfactants, builders, chelating agents, dye transfer inhibiting
agents, dispersants, enzymes, and enzyme stabilizers, catalytic
materials, bleach activators, polymeric dispersing agents, clay
soil removal/anti-redeposition agents, brighteners, suds
suppressors, dyes, additional perfume and perfume delivery systems,
structure elasticizing agents, fabric softeners, carriers,
hydrotropes, processing aids and/or pigments, metal salts,
structurants or binders, anti-tartar agents, anti-caries agents,
abrasives, fillers, humectants, breath agents, flavors,
antibacterial agents. In addition to the disclosure below, suitable
examples of such other adjuncts and levels of use are found in U.S.
Pat. No. 6,326,348 B1.
[0055] Each adjunct ingredient is not essential to Applicants'
compositions. Thus, certain embodiments of Applicants' compositions
may not contain one or more of the following adjuncts materials:
bleach activators, surfactants, builders, chelating agents, dye
transfer inhibiting agents, dispersants, enzymes, and enzyme
stabilizers, catalytic metal complexes, polymeric dispersing
agents, clay and soil removal/anti-redeposition agents,
brighteners, suds suppressors, dyes, additional perfumes and
perfume delivery systems, structure elasticizing agents, fabric
softeners, carriers, hydrotropes, processing aids and/or pigments,
metal salts, structurants or binders, anti-tartar agents,
anti-caries agents, abrasives, fillers, humectants, breath agents,
flavors, antibacterial agents. However, when one or more adjuncts
are present, such adjuncts may be present as detailed below:
[0056] Surfactants--The compositions according to the present
invention can comprise a surfactant or surfactant system wherein
the surfactant can be selected from nonionic and/or anionic and/or
cationic surfactants and/or ampholytic and/or zwitterionic and/or
semi-polar nonionic surfactants. The surfactant is typically
present at a level of from about 0.1%, from about 1%, or even from
about 5% by weight of the cleaning compositions to about 99.9%, to
about 80%, to about 35%, or even to about 30% by weight of the
cleaning compositions.
[0057] Builders--The compositions of the present invention can
comprise one or more detergent builders or builder systems. When
present, the compositions will typically comprise at least about 1%
builder, or from about 5% or 10% to about 80%, 50%, or even 30% by
weight, of said builder. Builders include, but are not limited to,
the alkali metal, ammonium and alkanolammonium salts of
polyphosphates, alkali metal silicates, alkaline earth and alkali
metal carbonates, aluminosilicate builders polycarboxylate
compounds. ether hydroxypolycarboxylates, copolymers of maleic
anhydride with ethylene or vinyl methyl ether,
1,3,5-trihydroxybenzene-2,4,6-trisulphonic acid, and
carboxymethyl-oxysuccinic acid, the various alkali metal, ammonium
and substituted ammonium salts of polyacetic acids such as
ethylenediamine tetraacetic acid and nitrilotriacetic acid, as well
as polycarboxylates such as mellitic acid, succinic acid,
oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic
acid, carboxymethyloxysuccinic acid, and soluble salts thereof.
[0058] Chelating Agents--The compositions herein may also
optionally contain one or more copper, iron and/or manganese
chelating agents. If utilized, chelating agents will generally
comprise from about 0.1% by weight of the compositions herein to
about 15%, or even from about 3.0% to about 15% by weight of the
compositions herein.
[0059] Dye Transfer Inhibiting Agents--The compositions of the
present invention may also include one or more dye transfer
inhibiting agents. Suitable polymeric dye transfer inhibiting
agents include, but are not limited to, polyvinylpyrrolidone
polymers, polyamine N-oxide polymers, copolymers of
N-vinylpyrrolidone and N-vinylimidazole, polyvinyloxazolidones and
polyvinylimidazoles or mixtures thereof. When present in the
compositions herein, the dye transfer inhibiting agents are present
at levels from about 0.0001%, from about 0.01%, from about 0.05% by
weight of the cleaning compositions to about 10%, about 2%, or even
about 1% by weight of the cleaning compositions.
[0060] Dispersants--The compositions of the present invention can
also contain dispersants. Suitable water-soluble organic materials
are the homo- or co-polymeric acids or their salts, in which the
polycarboxylic acid may comprise at least two carboxyl radicals
separated from each other by not more than two carbon atoms.
[0061] Enzymes--The compositions can comprise one or more detergent
enzymes which provide cleaning performance and/or fabric care
benefits. Examples of suitable enzymes include, but are not limited
to, hemicellulases, peroxidases, proteases, cellulases, xylanases,
lipases, phospholipases, esterases, cutinases, pectinases,
keratanases, reductases, oxidases, phenoloxidases, lipoxygenases,
ligninases, pullulanases, tannases, pentosanases, malanases,
B-glucanases, arabinosidases, hyaluronidase, chondroitinase,
laccase, and amylases, or mixtures thereof. A typical combination
is a cocktail of conventional applicable enzymes like protease,
lipase, cutinase and/or cellulase in conjunction with amylase.
[0062] Enzyme Stabilizers--Enzymes for use in compositions, for
example, detergents can be stabilized by various techniques. The
enzymes employed herein can be stabilized by the presence of
water-soluble sources of calcium and/or magnesium ions in the
finished compositions that provide such ions to the enzymes.
[0063] Catalytic Metal Complexes--Applicants' compositions may
include catalytic metal complexes. One type of metal-containing
bleach catalyst is a catalyst system comprising a transition metal
cation of defined bleach catalytic activity, such as copper, iron,
titanium, ruthenium, tungsten, molybdenum, or manganese cations, an
auxiliary metal cation having little or no bleach catalytic
activity, such as zinc or aluminum cations, and a sequestrate
having defined stability constants for the catalytic and auxiliary
metal cations, particularly ethylenediaminetetraacetic acid,
ethylenediaminetetra (methyl-enephosphonic acid) and water-soluble
salts thereof. Such catalysts are disclosed in U.S. Pat. No.
4,430,243.
[0064] If desired, the compositions herein can be catalyzed by
means of a manganese compound. Such compounds and levels of use are
well known in the art and include, for example, the manganese-based
catalysts disclosed in U.S. Pat. No. 5,576,282. Cobalt bleach
catalysts useful herein are known, and are described, for example,
in U.S. Pat. No. 5,597,936.
[0065] Compositions herein may also suitably include a transition
metal complex of a macropolycyclic rigid ligand--abbreviated as
"MRL". As a practical matter, and not by way of limitation, the
compositions and cleaning processes herein can be adjusted to
provide on the order of at least one part per hundred million of
the benefit agent MRL species in the aqueous washing medium, and
may provide from about 0.005 ppm to about 25 ppm, from about 0.05
ppm to about 10 ppm, or even from about 0.1 ppm to about 5 ppm, of
the MRL in the wash liquor. Suitable transition-metals in the
instant transition-metal bleach catalyst include manganese, iron
and chromium. Suitable MRL's herein are a special type of
ultra-rigid ligand that is cross-bridged such as
5,12-diethyl-1,5,8,12-tetraazabicyclo[6.6.2]hexa-decane. Suitable
transition metal MRLs are readily prepared by known procedures,
such as taught for example in and U.S. Pat. No. 6,225,464.
Methods of Use
[0066] Some of the consumer products disclosed herein can be used
to clean or treat a situs inter alia a surface or fabric. Typically
at least a portion of the situs is contacted with an embodiment of
Applicants' composition, in neat form or diluted in a liquor, for
example, a wash liquor and then the situs may be optionally washed
and/or rinsed. In one aspect, a situs is optionally washed and/or
rinsed, contacted with a composition according to the present
invention and then optionally washed and/or rinsed. The situs may
also then be dried via line drying and/or machine drying. For
purposes of the present invention, washing includes but is not
limited to, scrubbing, and mechanical agitation. The fabric may
comprise most any fabric capable of being laundered or treated in
normal consumer use conditions. Liquors that may comprise the
disclosed compositions may have a pH of from about 3 to about 11.5.
Such compositions are typically employed at concentrations of from
about 500 ppm to about 15,000 ppm in solution. When the wash
solvent is water, the water temperature typically ranges from about
5.degree. C. to about 90.degree. C. and, when the situs comprises a
fabric, the water to fabric ratio is typically from about 1:1 to
about 30:1.
Test Methods
[0067] It is understood that the test methods that are disclosed in
the Test Methods Section of the present application should be used
to determine the respective values of the parameters of Applicants'
invention as such invention is described and claimed herein.
(1) C log P
[0068] The log P values of many perfume ingredients have been
reported; for example, the Pomona92 database, available from
Daylight Chemical Information Systems, Inc. (Daylight CIS), Irvine,
Calif., contains many, along with citations to the original
literature. However, the log P values are most conveniently
calculated by the "C LOG P" program, also available from Daylight
CIS. This program also lists experimental log P values when they
are available in the Pomona92 database. The "calculated log P" (C
log P) is determined by the fragment approach of Hansch and Leo
(cf., A. Leo, in Comprehensive Medicinal Chemistry, Vol. 4, C.
Hansch, P. G. Sammens, J. B. Taylor and C. A. Ramsden, Eds., p.
295, Pergamon Press, 1990, incorporated herein by reference). The
fragment approach is based on the chemical structure of each
perfume ingredient, and takes into account the numbers and types of
atoms, the atom connectivity, and chemical bonding. The C log P
values, which are the most reliable and widely used estimates for
this physicochemical property, are preferably used instead of the
experimental log P values in the selection of perfume ingredients
which are useful in the present invention.
(2) Boiling Point
[0069] Boiling point is measured by ASTM method D2887-04a,
"Standard Test Method for Boiling Range Distribution of Petroleum
Fractions by Gas Chromatography," ASTM International.
(3) Headspace Ratio
[0070] (a) Obtain a fragrance free consumer product formulation.
[0071] (b) Obtain fragrance microcapsules whose water content has
been adjusted to achieve a perfume content of 25 wt % in the
aqueous slurry. [0072] (c) Prepare Sample A by adding 2.0 grams of
the fragrance microcapsule aqueous slurry to 95 grams of the
fragrance free consumer product formulation. Then add 3.0 grams of
deionized water to balance the formulation to 100 grams. Age this
formulation for 1 week at 40 degrees Centigrade. [0073] (d) Prepare
Sample B by adding 0.50 grams of the neat fragrance to 95 grams of
fragrance free consumer product formulation. Then add 4.5 grams of
deionized water to balance the formulation to 100 grams. Age this
formulation for 1 week at 40 degrees Centigrade.
[0074] The Headspace Ratio for determining perfume leakage from a
perfume delivery system is defined as the headspace concentration
of Sample A divided by the headspace concentration of Sample B,
H Sample_A H Sample_B , ##EQU00001##
where H.sub.sample.sub.--.sub.A is the headspace concentration of a
consumer product formulation Sample A, and
H.sub.sample.sub.--.sub.B is the headspace concentration of a
consumer product formulation Sample B.
[0075] The Headspace Ratio for determining perfume delivery
efficiency from a perfume delivery system is defined as the
headspace concentration of Sample B divided by the headspace
concentration of Sample A,
H Sample_B H Sample_A , ##EQU00002##
where H.sub.Sample.sub.--.sub.A is the headspace concentration of a
consumer product formulation Sample A, and
H.sub.Sample.sub.--.sub.B is the headspace concentration of a
consumer product formulation Sample B.
[0076] Solid-Phase Micro-Extraction (SPME)-Gas Chromatography/Mass
Spectrometry is used to measure the level of perfume raw materials
in the headspace of products. 1.0 grams of the 1 week at 40 degrees
Centigrade aged sample are placed into a clean 20 ml headspace vial
and allowed to equilibrate for at least 2 hours at room
temperature.
[0077] The samples are then analyzed using the MPS2-SMPE-GC-MS
analysis system (GC-02001-0153, MSD-02001-0154,
MPS2-02001-0155).
Apparatus:
[0078] 1. 20 ml headspace vial [0079] 2. Timer. [0080] 3. Gas
Chromatograph (GC): Agilent model 6890 with a CIS-4 injector
(Gerstel, Mulheim, Germany) and MPS-2 Autosampler and TDU. For SPME
analysis, we used the split/splitless injector (not the CIS-4
injector). [0081] 4. GC column: J&W DB-5 MS, 30 M.times.0.25 mm
ID, 1.0 m film thickness obtained from J&W Scientific of
Folsom, Calif., USA. [0082] 5. Carrier gas, helium, 1.5 ml/min.
flow rate. [0083] 6. The injector liner is a special SPME liner
(0.75 mm ID) from Supelco. [0084] 7. The Detector is a model 5973
Mass Selective Detector obtained from Agilent Technologies, Inc.,
Wilmington, Del., USA having a source temperature of about
230.degree. C., and a MS Quad temperature of about 150.degree.
C.
Analysis Procedure:
[0084] [0085] 1. Transfer sample to proper sample tray and proceed
with SPME-GC-MS analysis. [0086] 2. Start sequence of sample
loading and analysis. In this step, the sample is allowed to
equilibrate for at least two hours on the auto sampler tray, then
sampled directly from the tray. The SPME fiber assembly is
DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5
minutes. [0087] 3. Injector temperature is at 260 C. [0088] 4. Then
GC-MS analysis run is started. Desorption time is 5 minutes. [0089]
5. The following temperature program is used: [0090] i) an initial
temperature of about 50.degree. C. which is held for 3 minutes,
[0091] ii) increase the initial temperature at a rate of about
6.degree. C./min until a temperature of about 250.degree. C. is
reached, then 25.degree. C./min to 275.degree. C., hold at about
275.degree. C. for 4.67 minute. [0092] 6. Perfume compounds are
identified using the MS spectral libraries of John Wiley & Sons
and the National Institute of Standards and Technology (NIST),
purchased and licensed through Hewlett Packard. [0093] 7.
Chromatographic peaks for specific ions are integrated using the
Chemstation software obtained from Agilent Technologies, Inc.,
Wilmington, Del., USA. [0094] 8. The ratio for each PRM is
calculated by dividing the peak area for the perfume raw material
in Sample A by the peak area in Sample B. [0095] 9. Each ratio is
then weighted by that perfume raw material's weight composition in
the perfume. [0096] 10. The Headspace Ratio is calculated as the
sum of the individual perfume raw material ratios obtained in step
9. (4) Perfume Leakage can also be Evaluated via % Liquid-Liquid
Extraction and Gas Chromatographic-Mass Spectrometric Analysis
[0097] When determining the % perfume leakage from Perfume
Microcapsules in liquid detergent, a fresh sample of liquid
detergent with equal level of free perfume (without Perfume
Microcapsules) must also be analyzed in parallel for reference.
[0098] 1. Preparation of an Internal Standard Solution [0099] Stock
solution of tonalid: Weigh 70 mg tonalid and add 20 ml hexane p.a.
[0100] Internal Standard Solution solution: Dilute 200 .mu.l of
stock solution in 20 ml hexane p.a. [0101] Mix to homogenize
[0102] 2. Perfume Extraction from Liquid Detergent without Perfume
Microcapsules (Reference) [0103] Weigh 2 g of liquid detergent
product into an extraction vessel [0104] Add 2 ml of Internal
Standard Solution and close vessel [0105] Extract perfume by gently
turning the extraction vessel upside-down for 20 times (manually)
[0106] Add spoon tip of Sodium Sulphate [0107] After separation of
layers, immediately transfer hexane-layer into Gas Chromatograph
auto sampler-vial and cap vial [0108] Inject splitless (1.5 .mu.l)
into Gas Chromatograph injection-port [0109] Run Gas
Chromatographic-Mass Spectrometric analysis
[0110] 3. Perfume Extraction from Liquid Detergent with Perfume
Microcapsules [0111] Weigh 2 g of liquid detergent product into an
extraction vessel [0112] Add 2 ml of Internal Standard Solution and
close vessel [0113] Extract perfume by gently turning the
extraction vessel upside-down for 20 times (manually) [0114] Add
spoon tip of Sodium Sulphate [0115] After separation of layers,
immediately transfer hexane-layer into Gas Chromatograph auto
sampler-vial and cap vial [0116] Inject splitless (1.5 .mu.l) into
Gas Chromatograph injection-port [0117] Run Gas
Chromatographic-Mass Spectrometric analysis
[0118] 4. Calculation [0119] The perfume leakage from capsules per
individual Perfume Raw Material:
[0119] % perfume leakage=((Area Perfume Raw Material
caps.times.Area Internal Standard Solution ref.times.Weight
ref)/(Area Internal Standard Solution caps.times.Area Perfume Raw
Material ref.times.Weight caps)).times.100
(5) Odor Detection Threshold (ODT)
[0120] Determined using a gas chromatograph. The gas chromatograph
is calibrated to determine the exact volume of material injected by
the syringe, the precise split ratio, and the hydrocarbon response
using a hydrocarbon standard of known concentration and chain
length distribution. The air flow rate is accurately measured and,
assuming the duration of human inhalation to last 12 seconds, the
sampled volume is calculated. Since the precise concentration at
the detector at any point in time is known, the mass per volume
inhaled is known, and hence the concentration of material.
[0121] For example, to determine whether a material has a threshold
below 50 parts per billion, solutions are delivered to the sniff
port at the calculated concentration. A panelist sniffs the GC
effluent and identifies the retention time when odor is noticed.
The average among 6 panelists determines the threshold of notice
ability. The necessary amount of analyte is injected into the
column to achieve a 50 parts per billion concentration at the
detector. Typical gas chromatograph parameters for determining odor
detection thresholds are listed below: [0122] GC: 5890 Series II
with FID detector, 7673 Autosampler [0123] Column: J&W
Scientific DB-1 [0124] Length: 30 meters, 0.25 millmeter inside
diameter, 1 micrometer film thickness [0125] Method: [0126] split
injection: 17/1 split ratio [0127] Autosampler: 1.13 microliters
per injection [0128] Column flow: 1.10 milliLiters per minute
[0129] Air Flow: 345 milliLiters per minute [0130] Inlet
Temperature: 245 degrees Centigrade [0131] Detector Temperature:
285 degrees Centigrade [0132] Initial Temperature=50 degrees
Centigrade, 5 degrees Centigrade per minute ramp rate, final
temperature=280 degrees Centigrade, Final time=6 minutes [0133]
Leading assumptions: 12 seconds per sniff, GC air adds to sample
dilution
(6) Coolant Screening on the TRPM8 Receptor
[0134] HEK-23 (human embryonic kidney) cells stably transfected
with human TRPM8 were grown in 15 ml growth medium [high glucose
DMEM (Dulbecco's Modification of Eagle's Medium) supplemented with
10% FBS (fetal bovine serum), 100 ug/ml Penicillin/streptomycin, 5
.mu.g/ml blasticindin, and 100 .mu.g/ml zeocin) in a 75 CM 2 flask
for 3 days at 37.degree. C. in a mammalian cell culture incubator
set at 5% CO2. Cells were detached with addition of 2 ml of
trypsin-EDTA buffer (GIBCO.RTM. 25200, Invitrogen) for about 2-3
min. Trypsin was inactivated by addition of 8 ml growth medium.
Cells were transferred to a 50 ml tube and centrifuged at 850 rpm
for 3 minutes to remove medium. After centrifugation, a pellet of
cells was formed in the bottom of the tube separating them from the
supernatant solution. The supernatant was discarded and the cell
pellet was suspended in 1 ml of fresh growth medium to which 5 ul
(12.5 ug) of Fluo-4 AM (Molecular Probes, Inc.) calcium indicator
was added and incubated for 30 min with gentle shaking. (Fluo-4 is
a fluorescent dye used for quantifying cellular Ca t concentrations
in the 100 nM to 1 microM range.) At the end of 30 minutes, 45 ml
of assay buffer [1.times.HBSS (Hank's Balanced Salt Solution), 20
mM HEPES (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid)] was
added to wash cells and the resulting mixture was then centrifuged
at 850 rpm for 3 minutes to remove excess buffer and Fluo-4 AM
calcium indicator. The pellet cells were re-suspended in 10 ml
assay buffer and 90 ul aliquots (-50,000 cells) per well delivered
to a 96-well assay plate containing 10 ul of test compounds (1 mM
in assay buffer, final concentration 100 uM) or buffer control and
incubated at room temperature for 30 minutes. After 30 minutes,
plate is placed into a fluorometric imaging plate reader (FLIPR 384
from Molecular Devices) and basal fluorescence recorded (excitation
wave length 488 nm and emission wave length 510 nm). The FLIPR
assay is an accepted method for detecting changes in intracellular
calcium concentration. Then 20 ul of 37.5 uM of the compounds of
the invention were tested as TRPM8 agonist in the assay buffer
(final concentration 6.25 uM) was added and fluorescence recorded.
For determining the direct effect of test compounds on TRPM8,
fluorescence was measured immediately after addition of each
compound.
EXAMPLES
[0135] While particular embodiments of the present invention have
been illustrated and described, it would be obvious to those
skilled in the art that various other changes and modifications can
be made without departing from the spirit and scope of the
invention. It is therefore intended to cover in the appended claims
all such changes and modifications that are within the scope of
this invention.
Example 1
PRM Synthesis
TABLE-US-00001 [0136] Chemical Chemical Structure - 6 Structure - 7
member ring member ring variant IUPAC Names variant IUPAC Names 1
##STR00002## (R,S)-3-isobutyl-1,4,6- trimethyl-2-
oxabicyclo[2.2.2]octane ##STR00003## (R,S)-7-isobutyl-1,4,5-
trimethyl-6- oxabicyclo[3.2.1]octane 2 ##STR00004##
(R,S)-3-butyl-4-ethyl- 1,6-dime-thyl-2- oxabicyclo[2.2.2]octane
##STR00005## (R,S)-7-butyl-1-ethyl- 4,5-dimethyl-6-
oxabicyclo[3.2.1]octane 3 ##STR00006## (R,S)-1,3,4,6-
tetramethyl-2- oxabicyclo[2.2.2]octane ##STR00007## (R,S)-1,4,5,7-
tetramethyl-6- oxabicyclo[3.2.1]octane 4 ##STR00008##
(R,S)-4-ethyl-1,3,6- trimethyl-2-oxa- bicyclo[2.2.2]octane
##STR00009## (R,S)-1-ethyl-4,5,7- trimethyl-6-
oxabicyclo[3.2.1]octane 5 ##STR00010## (R,S)-4-isopropyl-1,6-
dimethyl-2-oxa- bicyclo[2.2.2]octane ##STR00011##
(R,S)-1-isopropyl-4,5- dimethyl-6- oxabicyclo[3.2.1]octane 6
##STR00012## 1,6-dimethyl-4-(R,S)- propyl-2-oxa-
bicyclo[2.2.2]octane ##STR00013## (R,S)-4,5-dimethyl-1- propyl-6-
oxabicyclo[3.2.1]octane 7 ##STR00014## 4-(R,S)-allyl-1,6-
dimethyl-2-oxa- bicyclo[2.2.2]octane ##STR00015##
(R,S)-1-allyl-4,5- dimethyl-6- oxabicyclo[3.2.1]octane 8
##STR00016## (R,S)-1,4,6-trimethyl-2- oxa- bicyclo[2.2.2]octane
##STR00017## (R,S)-1,4,5-trimethyl-6- oxabicyclo[3.2.1]octane 9
##STR00018## (R,S)-1,3,3,4,6- pentamethyl-2-oxa-
bicyclo[2.2.2]octane ##STR00019## (R,S)-1,4,5,7,7- pentamethyl-6-
oxabicyclo[3.2.1]octane 10 ##STR00020## (R,S)-4-ethyl-1,6-
dimethyl-2-oxa- bicyclo[2.2.2]octane ##STR00021##
(R,S)-1-ethyl-4,5- dimethyl-6- oxabicyclo[3.2.1]octane 11
##STR00022## 1,3,6-trimethyl-4- propyl-2- oxabicyclo[2.2.2]octane
##STR00023## (R,S)-4,5,7-trimethyl-1- propyl-6-
oxabicyclo[3.2.1]octane 12 ##STR00024## 4-butyl-1,3,6-trimethyl- 2-
oxabicyclo[2.2.2]octane ##STR00025## (R,S)-1-butyl-4,5,7-
trimethyl-6- oxabicyclo[3.2.1]octane 13 ##STR00026##
3-butyl-1,4,6-trimethyl- 2- oxabicyclo[2.2.2]octane ##STR00027##
(R,S)-7-butyl-1,4,5- trimethyl-6- oxabicyclo[3.2.1]octane
Example 1
Synthesis of Table 1 Molecules
Synthesis of 3,4-dimethylcyclohex-3-enecarbonitrile
##STR00028##
[0138] A solution of acrylonitrile (1 eq.) and
2,3-dimethylbuta-1,3-diene (1.1 eq.) in toluene (2M) was pumped
through a heated coil reactor at 240.degree. C. with a residence
time of 10 minutes. The resulting mixture was concentrated under
reduced pressure and yielded the product as colorless oil (87%
yield).
Synthesis of methyl 3,4-dimethylcyclohex-3-enecarboxylate
##STR00029##
[0140] A solution of methyl acrylate (1 eq.) and
2,3-dimethylbuta-1,3-diene (1.1 eq.) in toluene (2M) was pumped
through a heated coil reactor at 220.degree. C. with a residence
time of 17 minutes. The resulting mixture was concentrated under
reduced pressure and yielded the product as colorless oil (87%
yield).
Synthesis of Intermediates, Alkylations
3,4-dimethylcyclohex-3-enecarbonitrile or methyl
3,4-dimethylcyclohex-3-enecarboxylate
##STR00030##
TABLE-US-00002 [0141] Intermediate for --R R.sub.1 compound # Table
1 X --CN methyl 1, 3 & 13 I --CN ethyl 2 & 4 Br --CN
n-propyl 11 I --CN n-butyl 12 I --CO.sub.2Me methyl 8 & 9 I
--CO.sub.2Me ethyl 10 Br --CO.sub.2Me iso-propyl 5 I --CO.sub.2Me
n-propyl 6 I --CO.sub.2Me allyl 7 Br
[0142] A representative procedure for the methylation of
3,4-dimethylcyclohex-3-enecarbonitrile:
[0143] To a solution of di-isopropylamine (1.05 eq.) in dry THF
(0.5 M) at 0.degree. C., was added drop wise a solution of
n-butyllithium (1.05 eq.-2.2 M cyclohexane). After stirring for 10
minutes at the same temperature,
3,4-dimethylcyclohex-3-enecarbonitrile (1 eq.) was added drop wise
to this mixture. After another 10 minutes, iodomethane was added
drop wise at 0.degree. C. Complete conversion was observed after 10
minutes stirring. The reaction was quenched by addition of a
saturated NH.sub.4Cl aqueous solution and extracted with Et.sub.2O.
The combined organic layers were dried over MgSO.sub.4 and
concentrated under reduced pressure. The resulting oil was purified
using a quick filtration over silica by elution with a petroleum
ether--Et.sub.2O mixture (9-1). Concentration of the eluent under
reduced pressure resulted in the compound as a colorless oil (92%
yield).
Synthesis of Intermediates, Nitrile Alkylations
##STR00031##
TABLE-US-00003 [0144] Intermediate for R.sub.1 R.sub.2 compound #
Table 1 methyl iso-butyl 1 ethyl n-butyl 2 methyl n-butyl 13 methyl
methyl 3 ethyl methyl 4 n-propyl methyl 11 n-butyl methyl 12
[0145] A representative procedure is given for the synthesis of
intermediate for compound 3.
[0146] A methyllithium solution (1.2 equiv.) was added drop wise to
a solution of the nitrile (1 eq.) in dry THF (0.5M) at -20.degree.
C. After stifling for 15 minutes at -10/-20.degree. C., full
conversion was observed by GC-MS. The reaction was quenched with a
H.sub.2SO.sub.4 solution (2M-2 eq.) and stirred at ambient
temperature till full hydrolysis of the in situ formed imine was
observed. The mixture was then extracted with Et.sub.2O and washed
with a saturated NaHCO.sub.3 aqueous solution. The combined organic
phases were dried over MgSO.sub.4 and concentrated under reduced
pressure. The resulting oil was purified using a quick filtration
over silica gel by eluting with a petroleum ether--Et.sub.2O
mixture (9-1). Concentration of the eluent under reduced pressure
resulted in the compound as a colorless oil (89% yield).
Synthesis of Intermediates, Reduction of Ketones/Methyl Esters
##STR00032##
TABLE-US-00004 [0147] Intermediate for R.sub.1 R.sub.2 compound #
Table 1 methyl iso-butyl 1 ethyl n-butyl 2 methyl methyl 3 ethyl
methyl 4 iso-propyl --OMe 5 n-propyl --OMe 6 allyl --OMe 7 methyl
--OMe 8 ethyl --OMe 10 n-propyl methyl 11 n-butyl methyl 12 methyl
n-butyl 13
[0148] A representative procedure is given for the synthesis of
intermediate for compound 1.
[0149] To a solution of ketone (1 eq.) in dry THF (0.5 M) was added
portion wise lithium-aluminiumhydride (0.5 eq.) at 0.degree. C.
Reaction completion was observed by GC-MS after 15 minutes of
stirring at ambient temperature. The mixture was cooled to
0.degree. C. and consequently was added: water (same amount of mL
as mg hydride used), 15% NaOH solution (same amount of mL as mg
hydride used) & water (2 times amount of mL as mg hydride
used). This quenching was followed by stirring for 1 hour at
ambient temperature. The resulting mixture was filtered over celite
and the filter was washed with Et.sub.2O. Concentration of the
filtrate under reduced pressure resulted in the compound as a
colorless oil (94% yield).
Synthesis of Intermediate,
2-(1,3,4-trimethylcyclohex-3-en-1-yl)propan-2-ol
##STR00033##
[0151] To a solution of methyl
1,3,4-trimethylcyclohex-3-enecarboxylate (1 eq.) in dry THF (0.5 M)
at -20.degree. C. was added drop wise a solution of methylmagnesium
iodide (2.1 eq.-3 M). The resulting mixture was stirred overnight
at ambient temperature and successively quenched with a saturated
NH.sub.4Cl solution and extracted with Et.sub.2O. The combined
organic layers were dried over MgSO.sub.4 and concentrated under
reduced pressure. The resulting oil was purified using a quick
filtration over silica by elution with a petroleum ether--Et.sub.2O
mixture (1-1). Concentration of the eluent under reduced pressure
resulted in the compound as a colorless oil (86% yield).
Synthesis of Compounds 1-10 Table 1
##STR00034##
TABLE-US-00005 [0152] Intermediate for R.sub.1 R.sub.2 R.sub.3
compound # Table 1 methyl iso-butyl H 1 ethyl n-butyl H 2 methyl
methyl H 3 ethyl methyl H 4 iso-propyl H H 5 n-propyl H H 6 allyl H
H 7 methyl H H 8 methyl methyl methyl 9 ethyl H H 10 n-propyl
methyl H 11 n-butyl methyl H 12 methyl n-butyl H 13
[0153] A representative procedure is given for the synthesis of
intermediate for compound 3 Table 1.
[0154] A mixture of 1-(1,3,4-trimethylcyclohex-3-en-1-yl)ethanol (1
eq.) and Cu(OTf).sub.2 (3 mol %) in toluene is stirred overnight at
65.degree. C. The resulting mixture is concentrated under reduced
pressure and purified using a quick filtration over silica by
elution with a petroleum ether--Et.sub.2O mixture (9-1).
Concentration of the eluent under reduced pressure resulted in the
compound as a colorless oil (65% yield).
Example 2
84 wt % Core/16 wt % Wall Melamine Formaldehyde (MF) Capsule (PAD
Reservoir System
[0155] 17 grams of butyl acrylate-acrylic acid copolymer emulsifier
(Colloid C351, 25% solids, pka 4.5-4.7, (Kemira Chemicals, Inc.
Kennesaw, Ga. U.S.A.) and 17 grams of polyacrylic acid (35% solids,
pKa 1.5-2.5, Aldrich) are dissolved and mixed in 200 grams
deionized water. The pH of the solution is adjusted to pH of 6.0
with sodium hydroxide solution. 7 grams of partially methylated
methylol melamine resin (Cymel 385, 80% solids, (Cytec Industries
West Paterson, N.J., U.S.A.)) is added to the emulsifier solution.
200 grams of perfume oil is added to the previous mixture under
mechanical agitation and the temperature is raised to 45.degree. C.
After mixing at higher speed until a stable emulsion is obtained,
the second solution and 4 grams of sodium sulfate salt are added to
the emulsion. This second solution contains 3 grams of polyacrylic
acid polymer (Colloid C121, 25% solids (Kemira Chemicals, Inc.
Kennesaw, Ga. U.S.A.), 100 grams of distilled water, sodium
hydroxide solution to adjust pH to 6.0, 10 grams of partially
methylated methyol melamine resin (Cymel 385, 80% Cytec). This
mixture is heated till 85 C and maintained 8 hours with continuous
stirring to complete the encapsulation process. 23 grams of
acetoacetamide (Sigma-Aldrich, Saint Louis, Mo. U.S.A.) is added to
the suspension. Salts and structuring agents can then still be
added to the slurry.
Example 3
Process of Making a Polymer Assisted Delivery (PAD) Matrix
System
[0156] A mixture comprising 50% of a perfume composition comprising
one or more Table 1 PRMs, 40% of carboxyl-terminated Hypro.TM. RLP
1300X18 (CAS#0068891-50-9) from nanoresins, (put at 60.degree. C.
in warm water bath for 1 hour before mixing) and 10% of
Lupasol.RTM. WF(CAS#09002-98-6) from BASF (put at 60.degree. C. in
warm water bath for 1 hour before mixing). Mixing is achieved by
mixing for five minutes using a Ultra-Turrax T25 Basic equipment
(from IKA). After mixing, the mixture is put in a warm water bath
at 60.degree. C. for .+-.12 hours. A homogenous, viscous and sticky
material is obtained.
[0157] In the same way as described above different ratios between
the components can be used:
TABLE-US-00006 Weight % Perfume composition 40 50 60 70 80 Lupasol
.RTM. WF 12 10 8 6 4 Hypro .TM. RLP 48 40 32 24 16 CTBN1300X18
Weight % Perfume composition 50 50 50 50 50 50 50 50 Lupasol .RTM.
WF 2.5 5 7.5 10 12.5 15 17.5 20 Hypro .TM. RLP 47.5 45 42.5 40 37.5
35 32.5 30 CTBN 1300X18
Examples 4-51
Product Formulation
[0158] Non-limiting examples of product formulations containing
PRMs disclosed in the present specification perfume and amines
summarized in the following table.
Examples 4-9
[0159] Granular laundry detergent compositions for hand washing or
washing machines, typically top-loading washing machines.
TABLE-US-00007 4 5 6 7 8 9 (wt %) (wt %) (wt %) (wt %) (wt %) (wt
%) Linear alkylbenzenesulfonate 20 22 20 15 19.5 20 C.sub.12-14
Dimethylhydroxyethyl 0.7 0.2 1 0.6 0.0 0 ammonium chloride AE3S 0.9
1 0.9 0.0 0.4 0.9 AE7 0.0 0.0 0.0 1 0.1 3 Sodium tripolyphosphate 5
0.0 4 9 2 0.0 Zeolite A 0.0 1 0.0 1 4 1 1.6R Silicate
(SiO.sub.2:Na.sub.2O at 7 5 2 3 3 5 ratio 1.6:1) Sodium carbonate
25 20 25 17 18 19 Polyacrylate MW 4500 1 0.6 1 1 1.5 1 Random graft
copolymer.sup.1 0.1 0.2 0.0 0.0 0.05 0.0 Carboxymethyl cellulose 1
0.3 1 1 1 1 Stainzyme .RTM. (20 mg active/g) 0.1 0.2 0.1 0.2 0.1
0.1 Protease (Savinase .RTM., 32.89 mg 0.1 0.1 0.1 0.1 0.1
active/g) Amylase - Natalase .RTM. (8.65 mg 0.1 0.0 0.1 0.0 0.1 0.1
active/g) Lipase - Lipex .RTM. (18 mg active/g) 0.03 0.07 0.3 0.1
0.07 0.4 Fluorescent Brightener 1 0.06 0.0 0.06 0.18 0.06 0.06
Fluorescent Brightener 2 0.1 0.06 0.1 0.0 0.1 0.1 DTPA 0.6 0.8 0.6
0.25 0.6 0.6 MgSO.sub.4 1 1 1 0.5 1 1 Sodium Percarbonate 0.0 5.2
0.1 0.0 0.0 0.0 Sodium Perborate Monohydrate 4.4 0.0 3.85 2.09 0.78
3.63 NOBS 1.9 0.0 1.66 0.0 0.33 0.75 TAED 0.58 1.2 0.51 0.0 0.015
0.28 Sulphonated zinc phthalocyanine 0.0030 0.0 0.0012 0.0030
0.0021 0.0 S-ACMC 0.1 0.0 0.0 0.0 0.06 0.0 Direct Violet Dye (DV9
or 0.0 0.0 0.0003 0.0001 0.0001 0.0 DV99 or DV66) Additional Neat
Perfume .sup.(2) 0.5 0.5 0.5 0.5 0.5 0.5 Amine .sup.(1) 0.1 0.5 0.0
0.01 0.02 0.00 Perfume Delivery System As 0.05 0.0 0.1 0.0 0.2 0.4
Disclosed In The Present Specification Including Examples 2-3
Perfume comprising one or 0.3 0.4 0.01 0.02 0.04 0.1 more PRMs from
Table 1 Sulfate/Moisture Balance .sup.(1) One or more materials
comprising an amine moiety as disclosed in the present
specification. .sup.(2) Optional.
Examples 10-15
[0160] Granular laundry detergent compositions typically for
front-loading automatic washing machines.
TABLE-US-00008 10 11 12 13 14 15 (wt %) (wt %) (wt %) (wt %) (wt %)
(wt %) Linear alkylbenzenesulfonate 8 7.1 7 6.5 7.5 7.5 AE3S 0 4.8
1.0 5.2 4 4 C12-14 Alkylsulfate 1 0 1 0 0 0 AE7 2.2 0 2.2 0 0 0
C.sub.10-12 Dimethyl 0.75 0.94 0.98 0.98 0 0 hydroxyethylammonium
chloride Crystalline layered silicate (.delta.- 4.1 0 4.8 0 0 0
Na.sub.2Si.sub.2O.sub.5) Zeolite A 5 0 5 0 2 2 Citric Acid 3 5 3 4
2.5 3 Sodium Carbonate 15 20 14 20 23 23 Silicate 2R
(SiO.sub.2:Na.sub.2O at ratio 2:1) 0.08 0 0.11 0 0 0 Soil release
agent 0.75 0.72 0.71 0.72 0 0 Acrylic Acid/Maleic Acid 1.1 3.7 1.0
3.7 2.6 3.8 Copolymer Carboxymethylcellulose 0.15 1.4 0.2 1.4 1 0.5
Protease - Purafect .RTM. (84 mg 0.2 0.2 0.3 0.15 0.12 0.13
active/g) Amylase - Stainzyme Plus .RTM. (20 mg 0.2 0.15 0.2 0.3
0.15 0.15 active/g) Lipase - Lipex .RTM. (18.00 mg active/g) 0.05
0.15 0.1 0 0 0 Amylase - Natalase .RTM. (8.65 mg 0.1 0.2 0 0 0.15
0.15 active/g) Cellulase - Celluclean .TM. (15.6 mg 0 0 0 0 0.1 0.1
active/g) TAED 3.6 4.0 3.6 4.0 2.2 1.4 Percarbonate 13 13.2 13 13.2
16 14 Na salt of Ethylenediamine-N,N'- 0.2 0.2 0.2 0.2 0.2 0.2
disuccinic acid, (S,S) isomer (EDDS) Hydroxyethane di phosphonate
0.2 0.2 0.2 0.2 0.2 0.2 (HEDP) MgSO.sub.4 0.42 0.42 0.42 0.42 0.4
0.4 Perfume 0.5 0.6 0.5 0.6 0.6 0.6 Suds suppressor agglomerate
0.05 0.1 0.05 0.1 0.06 0.05 Soap 0.45 0.45 0.45 0.45 0 0
Sulphonated zinc phthalocyanine 0.0007 0.0012 0.0007 0 0 0 (active)
S-ACMC 0.01 0.01 0 0.01 0 0 Direct Violet 9 (active) 0 0 0.0001
0.0001 0 0 Additional Neat Perfume .sup.(2) 0.5 0.5 0.5 0.5 0.5 0.5
Amine .sup.(1) 0.1 0.5 0.0 0.01 0.02 0.00 Perfume Delivery System
As 0.05 0.0 0.1 0.0 0.2 0.4 Disclosed In The Present Specification
Including Examples 2-3 Perfume comprising one or more 0.3 0.4 0.01
0.02 0.04 0.1 PRMs from Table 1 Sulfate/Water & Miscellaneous
Balance .sup.(1) One or more materials comprising an amine moiety
as disclosed in the present specification. .sup.(2) Optional.
[0161] The typical pH is about 10.
Examples 16-22
Heavy Duty Liquid Laundry Detergent Compositions
TABLE-US-00009 [0162] 16 17 18 19 20 21 22 (wt %) (wt %) (wt %) (wt
%) (wt %) (wt %) (wt %) AES C.sub.12-15 alkyl ethoxy (1.8) sulfate
11 10 4 6.32 0 0 0 AE3S 0 0 0 0 2.4 0 0 Linear alkyl benzene
sulfonate/ 1.4 4 8 3.3 5 8 19 sulfonic acid HSAS 3 5.1 3 0 0 0 0
Sodium formate 1.6 0.09 1.2 0.04 1.6 1.2 0.2 Sodium hydroxide 2.3
3.8 1.7 1.9 1.7 2.5 2.3 Monoethanolamine 1.4 1.49 1.0 0.7 0 0 To pH
8.2 Diethylene glycol 5.5 0.0 4.1 0.0 0 0 0 AE9 0.4 0.6 0.3 0.3 0 0
0 AE8 0 0 0 0 0 0 20.0 AE7 0 0 0 0 2.4 6 0 Chelant (HEDP) 0.15 0.15
0.11 0.07 0.5 0.11 0.8 Citric Acid 2.5 3.96 1.88 1.98 0.9 2.5 0.6
C.sub.12-14 dimethyl Amine Oxide 0.3 0.73 0.23 0.37 0 0 0
C.sub.12-18 Fatty Acid 0.8 1.9 0.6 0.99 1.2 0 15.0
4-formyl-phenylboronic acid 0 0 0 0 0.05 0.02 0.01 Borax 1.43 1.5
1.1 0.75 0 1.07 0 Ethanol 1.54 1.77 1.15 0.89 0 3 7 A compound
having the following 0.1 0 0 0 0 0 2.0 general structure:
bis((C.sub.2H.sub.5O)(C.sub.2H.sub.4O)n)(CH.sub.3)--N.sup.+--C.sub.xH.sub.-
2x--N.sup.+--(CH.sub.3)-- bis((C.sub.2H.sub.5O)(C.sub.2H.sub.4O)n),
wherein n = from 20 to 30, and x = from 3 to 8, or sulphated or
sulphonated variants thereof Ethoxylated (EO.sub.15) tetraethylene
pentamine 0.3 0.33 0.23 0.17 0.0 0.0 0 Ethoxylated Polyethylenimine
0 0 0 0 0 0 0.8 Ethoxylated hexamethylene diamine 0.8 0.81 0.6 0.4
1 1 1,2-Propanediol 0.0 6.6 0.0 3.3 0.5 2 8.0 Fluorescent
Brightener 0.2 0.1 0.05 0.3 0.15 0.3 0.2 Hydrogenated castor oil
derivative structurant 0.1 0 0 0 0 0 0.1 Perfume 1.6 1.1 1.0 0.8
0.9 1.5 1.6 Protease (40.6 mg active/g) 0.8 0.6 0.7 0.9 0.7 0.6 1.5
Mannanase: Mannaway .RTM. (25 mg active/g) 0.07 0.05 0.045 0.06
0.04 0.045 0.1 Amylase: Stainzyme .RTM. (15 mg active/g) 0.3 0 0.3
0.1 0 0.4 0.1 Amylase: Natalase .RTM. (29 mg active/g) 0 0.2 0.1
0.15 0.07 0 0.1 Xyloglucanase (Whitezyme .RTM., 20 mg active/g) 0.2
0.1 0 0 0.05 0.05 0.2 Lipex .RTM. (18 mg active/g) 0.4 0.2 0.3 0.1
0.2 0 0 Additional Neat Perfume .sup.(2) 0.5 0.5 0.5 0.5 0.5 0.5
0.5 Amine .sup.(1) 0.1 0.5 0.0 0.01 0.02 0.00 0.07 Perfume Delivery
System As Disclosed In 0.05 0.0 0.1 0.0 0.2 0.4 0.0 The Present
Specification Including Examples 2-3 Perfume comprising one or more
PRMs 0.7 0.5 0.8 0.05 0.6 0.1 0.6 from Table 1 *Water, dyes &
minors Balance *Based on total cleaning and/or treatment
composition weight, a total of no more than 12% water .sup.(1) One
or more materials comprising an amine moiety as disclosed in the
present specification. .sup.(2) Optional.
Examples 23-24
Unit Dose Compositions
TABLE-US-00010 [0163] Example of Unit Dose detergents 23 24 C14-C15
alkyl poly ethoxylate (8) 12 -- C12-C14 alkyl poly ethoxylate (7) 1
14 C12-C14 alkyl poly ethoxylate (3) sulfate 8.4 9 Mono
EthanolAmine salt Linear Alkylbenzene sulfonic acid 15 16 Citric
Acid 0.6 0.5 C12-C18 Fatty Acid 15 17 Enzymes 1.5 1.2 PEI 600 EO20
4 -- Diethylene triamine penta methylene 1.3 -- phosphonic acid or
HEDP Fluorescent brightener 0.2 0.3 Hydrogenated Castor Oil 0.2 0.2
1,2 propanediol 16 12 Glycerol 6.2 8.5 Sodium hydroxide -- 1 Mono
Ethanol Amine 7.9 6.1 Dye Present Present PDMS -- 2.7 Potassium
sulphite 0.2 0.2 Additional Neat Perfume.sup.(2) 0.5 0.5
Amine.sup.(1) 0.1 0.5 Perfume Delivery System As Disclosed In The
0.05 0.0 Present Specification Including Examples 2-3 Perfume
comprising one or more PRMs from 0.3 0.4 Table 1 Water Up to Up to
100p 100 .sup.(1)One or more materials comprising an amine moiety
as disclosed in the present specification. .sup.(2)Optional.
Example 25-30
Bleach & Laundry Additive Detergent Formulations
TABLE-US-00011 [0164] Ingredients 25 26 27 28 29 30 AES 11.3 6.0
15.4 16.0 12.0 10.0 LAS 25.6 12.0 4.6 -- -- 26.1 MEA-HSAS -- -- --
3.5 -- -- DTPA: Diethylene 0.51 -- 1.5 -- -- 2.6 triamine
pentaacetic acid 4,5-Dihydroxy-1,3- 1.82 -- -- -- -- 1.4
benzenedisulfonic acid disodium salt 1,2-propandiol -- 10 -- -- --
15 Copolymer of 2.0 dimethylterephthalate, 1,2-propylene glycol,
methyl capped PEG Poly(ethyleneimine) 1.8 ethoxylated, PEI600 E20
Acrylic acid/maleic acid 2.9 copolymer Acusol 880 2.0 1.8 2.9
(Hydrophobically Modified Non-Ionic Polyol) Protease (55 mg/g
active) -- -- -- -- 0.1 0.1 Amylase (30 mg/g active) -- -- -- -- --
0.02 Brightener 0.21 -- -- 0.15 -- 0.18 Dye or mixture or dyes 0.01
0.005 0.006 0.002 0.007 0.008 selected from Examples 1- 28 in Table
1. Additional Neat Perfume .sup.(2) 0.5 0.5 0.5 0.5 0.5 0.5 Amine
.sup.(1) 0.1 0.5 0.0 0.01 0.02 0.00 Perfume Delivery System 0.05
0.0 0.1 0.0 0.2 0.4 As Disclosed In The Present Specification
Including Examples 2-3 Perfume comprising one 0.3 0.4 0.01 0.02
0.04 0.1 or more PRMs from Table 1 water, other optional to 100% to
100% to 100% to 100% to 100% to 100% agents/components* balance
balance balance balance balance balance .sup.(3) One or more
materials comprising an amine moiety as disclosed in the present
specification. .sup.(4) Optional. *Other optional agents/components
include suds suppressors, structuring agents such as those based on
Hydrogenated Castor Oil (preferably Hydrogenated Castor Oil,
Anionic Premix), solvents and/or Mica pearlescent aesthetic
enhancer.
Raw Materials and Notes for Composition Examples
[0165] LAS is linear alkylbenzenesulfonate having an average
aliphatic carbon chain length C.sub.9-C.sub.15 supplied by Stepan,
Northfield, Ill., USA or Huntsman Corp. (HLAS is acid form).
[0166] C.sub.12-14 Dimethylhydroxyethyl ammonium chloride, supplied
by Clariant GmbH, Germany
[0167] AE3S is C.sub.12-15 alkyl ethoxy (3) sulfate supplied by
Stepan, Northfield, Ill., USA
[0168] AE7 is C.sub.12-15 alcohol ethoxylate, with an average
degree of ethoxylation of 7, supplied by Huntsman, Salt Lake City,
Utah, USA
[0169] AES is C.sub.10-18 alkyl ethoxy sulfate supplied by Shell
Chemicals.
[0170] AE9 is C.sub.12-13 alcohol ethoxylate, with an average
degree of ethoxylation of 9, supplied by Huntsman, Salt Lake City,
Utah, USA
[0171] HSAS or HC1617HSAS is a mid-branched primary alkyl sulfate
with average carbon chain length of about 16-17
[0172] Sodium tripolyphosphate is supplied by Rhodia, Paris,
France
[0173] Zeolite A is supplied by Industrial Zeolite (UK) Ltd, Grays,
Essex, UK
[0174] 1.6R Silicate is supplied by Koma, Nestemica, Czech
Republic
[0175] Sodium Carbonate is supplied by Solvay, Houston, Tex.,
USA
[0176] Polyacrylate MW 4500 is supplied by BASF, Ludwigshafen,
Germany
[0177] Carboxymethyl cellulose is Finnfix.RTM. V supplied by CP
Kelco, Arnhem, Netherlands
[0178] Suitable chelants are, for example, diethylenetetraamine
pentaacetic acid (DTPA) supplied by Dow Chemical, Midland, Mich.,
USA or Hydroxyethane di phosphonate (HEDP) supplied by Solutia, St
Louis, Mo., USA Bagsvaerd, Denmark
[0179] Savinase.RTM., Natalase.RTM., Stainzyme.RTM., Lipex.RTM.,
Celluclean.TM., Mannaway.RTM. and Whitezyme.RTM. are all products
of Novozymes, Bagsvaerd, Denmark.
[0180] Proteases may be supplied by Genencor International, Palo
Alto, Calif., USA (e.g. Purafect Prime.RTM.) or by Novozymes,
Bagsvaerd, Denmark (e.g. Liquanase.RTM., Coronase.RTM.).
[0181] Fluorescent Brightener 1 is Tinopal.RTM. AMS, Fluorescent
Brightener 2 is Tinopal.RTM. CBS-X, Sulphonated zinc phthalocyanine
and Direct Violet 9 is Pergasol.RTM. Violet BN-Z all supplied by
Ciba Specialty Chemicals, Basel, Switzerland
[0182] Sodium percarbonate supplied by Solvay, Houston, Tex.,
USA
[0183] Sodium perborate is supplied by Degussa, Hanau, Germany
[0184] NOBS is sodium nonanoyloxybenzenesulfonate, supplied by
Future Fuels, Batesville, USA
[0185] TAED is tetraacetylethylenediamine, supplied under the
Peractive.RTM. brand name by Clariant GmbH, Sulzbach, Germany
[0186] S-ACMC is carboxymethylcellulose conjugated with C.I.
Reactive Blue 19, sold by Megazyme, Wicklow, Ireland under the
product name AZO-CM-CELLULOSE, product code S-ACMC.
[0187] Soil release agent is Repel-o-tex.RTM. PF, supplied by
Rhodia, Paris, France
[0188] Acrylic Acid/Maleic Acid Copolymer is molecular weight
70,000 and acrylate:maleate ratio 70:30, supplied by BASF,
Ludwigshafen, Germany
[0189] Na salt of Ethylenediamine-N,N'-disuccinic acid, (S,S)
isomer (EDDS) is supplied by Octel, Ellesmere Port, UK
[0190] Hydroxyethane di phosphonate (HEDP) is supplied by Dow
Chemical, Midland, Mich., USA
[0191] Suds suppressor agglomerate is supplied by Dow Corning,
Midland, Mich., USA
[0192] HSAS is mid-branched alkyl sulfate as disclosed in U.S. Pat.
No. 6,020,303 and U.S. Pat. No. 6,060,443
[0193] C.sub.12-14 dimethyl Amine Oxide is supplied by Procter
& Gamble Chemicals, Cincinnati, USA
[0194] Random graft copolymer is a polyvinyl acetate grafted
polyethylene oxide copolymer having a polyethylene oxide backbone
and multiple polyvinyl acetate side chains. The molecular weight of
the polyethylene oxide backbone is about 6000 and the weight ratio
of the polyethylene oxide to polyvinyl acetate is about 40:60 and
no more than 1 grafting point per 50 ethylene oxide units.
[0195] Ethoxylated polyethyleneimine is polyethyleneimine (MW=600)
with 20 ethoxylate groups per --NH.
[0196] Cationic cellulose polymer is LK400, LR400 and/or JR30M from
Amerchol Corporation, Edgewater N.J.
[0197] Note: all enzyme levels are expressed as % enzyme raw
material
[0198] The dimensions and values disclosed herein are not to be
understood as being strictly limited to the exact numerical values
recited. Instead, unless otherwise specified, each such dimension
is intended to mean both the recited value and a functionally
equivalent range surrounding that value. For example, a dimension
disclosed as "40 mm" is intended to mean "about 40 mm".
Example 31
Shampoo Formulations
TABLE-US-00012 [0199] Ingredient Ammonium Laureth Sulfate
(AE.sub.3S) 6.00 Ammonium Lauryl Sulfate (ALS) 10.00 Laureth-4
Alcohol 0.90 Trihydroxystearin.sup.(7) 0.10 Perfume comprising one
or more 0.60 PRMs from Table 1 Sodium Chloride 0.40 Citric Acid
0.04 Sodium Citrate 0.40 Sodium Benzoate 0.25 Ethylene Diamine
Tetra Acetic Acid 0.10 Dimethicone.sup.(9, 10, 11) 1.00.sup.(9)
Water and Minors (QS to 100%) Balance
Example 32-34
Fine Fragrance Formulations
TABLE-US-00013 [0200] Ingredient 32 33 34 Cyclic oligosaccharide 0
5 10 Ethanol 90 75 80 Perfume comprising one or more 10 20 10 PRMs
from Table 1
Example 35-48
Dentifrice Containing Sensate
TABLE-US-00014 [0201] Ingredient 35 36 37 38 39 40 41 42 43 Calcium
Peroxide 0.1 Carbomer 956 0.2 0.3 0.2 0.2 0.2 0.2 0.2 CMC 0.75 0.2
1.0 1.0 1.0 1.0 Color Solution (1%) 0.05 0.05 0.5 0.75 0.18 0.02
0.25 0.05 0.05 Wintergreen Spice Flavor 0.15 Fruit Mint Flavor 0.55
Mint Flavor 0.59 0.45 0.42 1.0 1.2 1.0 1.0 Cinnamon Flavor 0.5
Vanillyl Butyl Ether 0.02 WS-23 0.1 0.05 0.1 WS-3 0.2 0.05 0.2 MGA
0.2 Menthol 0.52 0.55 0.56 0.15 0.58 Sensate comprising one or 0.01
0.03 0.015 0.004 0.01 0.01 0.03 0.008 0.02 more PRMs from Table 1
Potassium Sorbate 0.004 0.008 0.004 0.004 Poloxamer 407 1.0 0.2 0.2
0.2 0.2 0.2 Polyethylene Glycol 300 3.0 3.0 3.0 Polyethylene Glycol
600 2.3 Propylene Glycol 10.0 Saccharin Sodium 0.46 0.5 0.45 0.4
0.58 0.4 0.4 0.4 0.4 Sucralose 0.02 0.02 0.02 Silica Abrasive 22.0
31.0 20.0 21.0 17.0 15.0 15.0 15.0 15.0 Sodium Benzoate 0.004 0.004
0.004 0.004 Silica Thickening 2.0 7.0 7.0 7.0 7.0 Sodium
Bicarbonate 1.5 9.0 Sodium Carbonate 0.5 NaOH 50% soln 1.74 2.2 2.0
2.0 2.0 2.0 Na Lauryl Sulfate (27.9% 4.0 5.0 3.0 4.0 4.0 3.0 2.0
soln) Stannous Fluoride 0.454 0.454 Sodium Fluoride 0.243 0.243
0.243 Sodium MFP 0.76 0.76 0.76 0.76 Glycerin USP 99.7% 9.0 11.9
33.0 9.0 Sorbitol Soln USP 24.3 24.5 4.0 44.7 56.9 43.0 43.0 40.0
38.0 Tetra Na Pyrophosphate 2.05 5.045 3.85 3.85 Anhydrous Tetra
Potassium 6.38 Pyrophosphate (60% Soln) Na Acid Pyrophosphate 2.1
4.0 1.0 4.3 4.5 4.5 2.0 Alkyl Phosphate 3.5 6.7 3.5 3.5
Cocamidopropyl Betaine 3.5 (30% Soln) TitaniumDioxide 0.5 1.0 0.25
0.3 0.3 0.2 0.2 Ti02/Carnauba Wax Prills 0.6 0.3 Xanthan Gum 0.6
0.4 0.45 0.7 0.3 0.3 0.3 0.3 Water Purified USP QS QS QS QS QS QS
QS QS QS Ingredient 44 45 46 47 48 Calcium Carbonate 40.0 Dibasic
Calcium Phosphate 35.0 Dihydrate Silica Abrasive 24.0 12.5 17.0
Phytic Acid 0.8 2.0 Gantrez S-97 2.0 Color Solution (1%) 0.05 0.05
0.05 Saccharin sodium 0.47 0.25 0.3 0.3 0.58 Spice Mint Flavor 1.0
Wintergreen Spice Flavor 1.2 0.15 Mint Flavor 0.3 0.6 0.5 0.42
Cinnamon Flavor 0.18 WS-23 Coolant 0.03 0.02 WS-3 Coolant 0.03 0.02
MGA 0.08 0.08 Menthol 0.38 0.24 0.2 0.5 0.58 Sensate comprising one
or 0.08 0.005 0.004 0.008 0.01 more PRMs from Table 1 Glycerin 16.5
15.0 Sorbitol solution 10.5 33.0 11.5 14.0 57.0 Poloxamer 407 0.2
Polyethylene Glycol 300 2.5 Polyethylene Glycol 600 3.0 Carbomer
0.3 0.2 CMC 7M8SF 1.0 1.0 1.0 1.0 HEC 250MX 0.5 Sodium Lauryl
Sulfate 7.5 7.0 5.5 7.0 4.0 (27.9% soln) NaOH 50% soln 1.0 Sodium
0.76 0.76 0.76 0.76 Monofluorophosphate Sodium Fluoride 0.32 Sodium
Gluconate 1.0 Stannous Chloride 1.0 Dihydrate Zinc Citrate 0.5
Potassium Nitrate 5.0 Sodium Phosphate, 3.2 Tribasic Tetra Sodium
0.5 0.5 3.85 Pyrophosphate, Anhydrous Sodium Acid 1.0 Pyrophosphate
TitaniumDioxide 0.5 0.5 0.25 Xanthan Gum (Keltro 1000 0.5 0.7
Carrageenan 0.5 Water, Purified, USP QS QS QS QS QS
Example 49-51
Mouthrinse Containing Sensate
TABLE-US-00015 [0202] Ingredient 49 50 51 Ethanol USP 190 proof 15
15 15 Glycerin 7.5 7.5 7.5 Polysorbate 80 NF 0.12 0.12 0.12 Flavor'
0.16 0.16 0.16 Saccharin sodium 0.067 0.067 0.06 Color solution
0.04 0.04 0.04 Sensate comprising one or more PRMs 0.03 0.017 1
from Table 1 Calcium chloride 0.025 0.025 0.025 Cetylpyridinium
chloride 0.045 0.045 0.045 Benzoic acid 0.005 0.005 0.005 Sodium
benzoate 0.054 0.054 0.054 Water QS QS QS
[0203] The dimensions and values disclosed herein are not to be
understood as being strictly limited to the exact numerical values
recited. Instead, unless otherwise specified, each such dimension
is intended to mean both the recited value and a functionally
equivalent range surrounding that value. For example, a dimension
disclosed as "40 mm" is intended to mean "about 40 mm".
[0204] All documents cited in the Detailed Description of the
Invention are, in relevant part, incorporated herein by reference;
the citation of any document is not to be construed as an admission
that it is prior art with respect to the present invention. To the
extent that any meaning or definition of a term in this document
conflicts with any meaning or definition of the same term in a
document incorporated by reference, the meaning or definition
assigned to that term in this document shall govern.
[0205] While particular embodiments of the present invention have
been illustrated and described, it would be obvious to those
skilled in the art that various other changes and modifications can
be made without departing from the spirit and scope of the
invention. It is therefore intended to cover in the appended claims
all such changes and modifications that are within the scope of
this invention.
* * * * *