Composition For Detecting The Response Of Rectal Adenocarcinomas To Radiochemotherapy

Abstract

A cDNA array (9984 genes) was used for expression profiling in rectal adenocarcinoma. The expression data were correlated to responsiveness to chemotherapy followed by radiotherapy. A set of 54 genes was found that were differentially expressed in responders vs. non-responders. The genes may be used as prognostic markers for determining whether a rectal adenocarcinoma is responsive to radiohemotherapy.

Description

[0001] This application claims the benefit of the filing date of U.S. Provisional Application Ser. No. 60/535,491, filed Jan. 12, 2004, whose disclosure is entirely incorporated by reference herein.

FIELD

[0002] The present invention relates, e.g., to a composition comprising a plurality of nucleic acid probes for use in research and diagnostic applications.

BACKGROUND INFORMATION

[0003] Rectal adenocarcinomas are among the most frequent malignant tumors in the Western World. Surgery, including total mesorectal resection, is the primary treatment for rectal carcinomas. In locally advanced stages of this disease, radiation or combined radiochemotherapy is mandatory. Whether radiochemotherapy should be administered prior to surgery (neoadjuvant) or after resection of the primary tumor (adjuvant), however, is still a matter of controversy (Sauer R. (2002) Pathol Oncol Res 8, 7-17; Pablman at al. (1998) Eur J Cancer; 34, 438-48; Nelson at al. (2001) N Engl J Med 345, 690-2). The decision to administer neoadjuvant radiochemotherapy relies primarily on the depth of tumor infiltration, which, in specialized centers is determined pie-therapeutically by rectal ultrasound (Liersch et al. (2003) Chirurg 74, 224-34; Hunerbein at al. Ann Surg (1997) 225, 432-8; Adams at al. (1999) Dis Colon Rectum 42, 159-66; Glaser et al. (1990) Br J Surg 77, 883-7). Neoadjuvant regimens might be particularly attractive (i) because a priori not curatively resectable tumors can be down-sized to achieve the undisputed benefit of tumor cell free surgical margins (R0-resection), (ii) because preoperative treatment reduces tumor burden and, therefore, might increase the possibility for sphincter preservation, and (iii) because radiochemotherapy cannot be applied when postoperative clinical complications occur.

[0004] However, the response of individual tumors to radiochemotherapy is not uniform. This poses a considerable clinical dilemma because patients with a priori resistant tumors could be spared exposure to radiation and DNA-damaging drugs, treatments that are associated with substantial side effects. In such cases surgery could be scheduled without delay. Alternatively, different neoadjuvant treatment modalities including additional chemotherapeutics could he pursued. It would therefore be of significant clinical relevance to identify predictive markers of cancer response to neoadjuvant radiochemotherapy.

[0005] Accordingly, numerous groups have employed targeted approaches to correlate expression levels of candidate genes in response to radiation, different chemotherapeutic drugs, and combinations of radiation and chemotherapy (for review see Pasche at al. (2002) Best Pract Res Clin Gastroenterol 16, 331-45; Adlard et al. (2002) Lancet Oncol 3, 75-82). The selections of candidate genes primarily included genes required for drug metabolism, drug activation, drug resistance, and DNA damage repair, and oncogenes and tumor suppressor genes involved in cell cycle control. Unfortunately, these candidate gene approaches have not materialized into sound pre-therapeutic predictors of response to radiochemotherapy. See, e.g., Okonkwo at al. (2001) Oncol Rep 8, 497-500; Saw et al (2003) Dis Colon Rectum 46, 192-202; Spitz at al. (1997) Clin Cancer Res 3, 1685-90; Luna-Perez at al. (1998) Ann Surg Oncol 5, 203-8; Elsaleb et al. (2000) Radiother Oncol 56, 239-44; Diez et al (2003) Oncology 64, 213-9; Scott at al. (1998) Eur J Surg Oncol 24, 169-73. There remains a need to establish reliable, clinically useful, predictors of radiochemosensitivity of rectal adenocarcinomas.

[0006] Parallel profiling of global gene expression levels based on microarray technologies has emerged as a powerful tool to monitor the transcriptome of cancer cells for tumor classification and prognosis (Rosenwald et at (2002) N Engl Med 346, 1937-47; van't Veer at al. (2002) Nature 415, 530-6; Iizuka et al. (2003) Lancet 361, 923-9; Bertucci at al. (2001) Lancet Oncol 2, 674-82; Yeoh et al (2002) Cancer Cell 1, 133-43). In addition, the power of gene expression profiling as a predictor of drug response has been explored in several model systems, including the NCI-60 cancer cell line panel (Staunton at al. (2001) Proc Natl Acad Sci USA 98, 10787-92; Scherf et al. (2000) Nat Genet 24, 236-44) and tumor xenografts (Zembutsu et al (2002) Cancer Res 62, 518-27). The results of these studies provide evidence that at least for some tumors and a subset of drugs, pre-therapeutic gene expression profiles might predict treatment response.

[0007] The present inventors have analyzed gene expression profiles of rectal adenocarcinomas, and have identified genes whose expression is correlated with responsiveness of the tumors to radiochemotherapy (e.g., neoadjuvant radiochemotherapy). Combinations comprising probes specific for these genes can be used in, diagnostic and experimental methods.

BRIEF DESCRIPTION OF THE DRAWINGS

[0008] FIG. 1 is a pictorial presentation of specimen accrual, clinical diagnosis, and experimental design. cUICC refers to pre-therapeutic clinical staging of tumors based on rectal ultrasound and computed tomography. ypUICC refers to histological assessment of the resected specimen after neoadjuvant therapy.

[0009] FIG. 2 shows a hierarchical cluster analysis of 23 patients based on the 54 most significantly changed genes (p<0.001) when using T-level-down-sizing. Note that in this cluster analysis, all but one patient (P15) were correctly assigned to the group of non-responders (13 patients on the left), while the 10 patients on the right were grouped as responders. Gene symbols and fold change between the groups are listed to the right. Values<1 reflect down-regulation (white) in the class of responders, whereas values>1 reflect up-regulation (grey).

DESCRIPTION OF Tap INVENTION

[0010] The present invention relates, e.g., to the identification of genes and gene products (molecular markers, molecular signatures) from rectal adenocarcinomas whose expression, compared to a baseline value, is correlated with the responsiveness of the tumors to radiochemotherapy. As used herein, a "baseline value" includes, e.g., the expression in normal tissue, such as normal rectal tissue, e.g. from the subject or from a "pool" of normal subjects; or from a pool of different tissues from normal subjects. In a preferred embodiment, the expression is from a pool of cell lines (e.g. of carcinogenic origin), such as the universal human reference library available from Stratagene (catalogue no. 740000). The pooled values may be either commercially available or otherwise derived. Alternatively, the baseline value may be the expression in rectal carcinomas that are known to be "non-responders" to radiochemotherapy, e.g. the average value from a pool or compilation of such tumor samples. The baseline value may be available in a database compiled from any of such values.

[0011] About 54 molecular markers are identified herein that are expressed in a significantly altered amount in rectal carcinomas that are responsive to radiochemotherapy, compared to rectal adenocarcinomas that are not responsive. Of the 54 molecular markers, 13 are up-regulated, and 41 are down-regulated, in responders compared to non-responders. Of course, other genes, as well, may be differentially regulated in responders compared to non-responders.

[0012] These molecular markers can serve as the basis for diagnostic assays to determine the responsiveness of a rectal carcinoma to radiochemotherapy. For example, nucleic acid probes corresponding to one or more of the genes, and/or antibodies specific for proteins encoded by the genes, can be used to analyze a sample from a rectal tumor, in order to determine the responsiveness. Molecules (e.g. nucleic acid probes, antibodies, etc) corresponding to any number of the 54 identified genes, in any combination or permutation, can be used in compositions and methods of the invention. The genes and gene products can also aid in the identification of therapeutic agents, e.g. agents which can be administered in conjunction with radiochemotherapy, and which enhance the responsiveness of a rectal tumor to the radiochemotherapy. Furthermore, the identification of genes whose expression is correlated with responsiveness to radiochemotherapy can also provide a basis for explaining the different metabolic processes involved in such responsiveness, and thus can be used as research tools.

[0013] One aspect of the invention is a composition (combination) comprising one or a plurality of (preferably at least about 5, at least about 10, or at least about 15) isolated nucleic acids of at least about 8 contiguous nucleotides (e.g., at least about 12, 15, 25, 35, 50 or 75 contiguous nucleotides), selected from nucleic acids that correspond to genes 1-54 from Table 3, and comprising no more than about 1.times.10.sup.6 (e.g., no more than about 500,000; 200,000; 100,000; 50,000; 25,000; 14,000; 13000; 12,000; 11,000; 10,000; 9,000; 8,000; 7,000; 6,000; 5,000, 4,000; 3,000; 2,000; 1,000; 500; 250; 150; 70 or 50) total isolated nucleic acids. In embodiments of the invention, the composition comprises at least about 5 (e.g., at least about 10, 15, 25, 50, 54, 60, 70 or 100 or more) nucleic acids that correspond to genes 1-54 from Table 3. In embodiments of the invention, at least one of the nucleic acids that correspond to genes 1-54 contains at least about 50 contiguous nucleotides, and'or is a eDNA. For example, the nucleic acids corresponding to genes 1-54 of Table 3 may be selected from:

[0014] (a) nucleic acids that comprise the sequences of SEQ ID NOs: 1-58 or 113-123;

[0015] (b) nucleic acids that comprise sequences that are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to the sequences of SEQ 1D NOs: 1-58 or 113-123;

[0016] (c) nucleic acids that comprise sequences encoding polypeptides represented by SEQ ID NOs: 59-112;

[0017] (d) nucleic acids that comprise sequences of active fragments of the nucleic acids of (a), (b), or (c);

[0018] (e) nucleic acids that comprise sequences of active variants of the nucleic acids of (a), (b), or (c) and/or

[0019] (f) nucleic acids that comprise complete complements of the sequences of any of the nucleic acids (a)-(e);

wherein the nucleic acids hybridize under conditions of high stringency to nucleic acids represented by SEQ ID NOs: 1-58 or 113-123, or to complements thereof.

[0020] The composition may be used, e.g., to determine the responsiveness of a rectal adenocarcinoma to radiochemotherapy.

[0021] As used herein, a "plurality" refers to two or more members, more preferably to a group of at least about 2, or at least about 5, or at least about 15, or at least about 54, etc., of the identified molecular markers.

[0022] As used herein, the term "isolated" nucleic acid (or polypeptide, or antibody) refers to a nucleic acid (or polypeptide, or antibody) that is in a form other than it occurs in nature, for example in a buffer, in a dry form awaiting reconstitution, as part of an array, a kit or a pharmaceutical composition, etc. The term an "isolated" nucleic acid or protein does not include a cell extract (e.g., a crude or semi-purified cell extract).

[0023] The majority of rectal tumors are carcinomas, and the majority of these rectal carcinomas are adenocarcinomas. The terms rectal tumor, carcinoma and adenocarcinoma are sometimes used interchangeably herein, with the understanding that the rectal tumors being discussed are preferably rectal adenocarcinomas. (It is noted that adenocarcinomas located in tissues other than the rectum may, under certain circumstances, also exhibit expression patterns similar to those discussed herein, with regard to responsiveness to radiochemotherapy.) A rectal adenocarcinoma that is "responsive to" radiochemotherapy is a tumor that is measurably more sensitive to such treatment than is a "non-responsive" tumor. The range of responsiveness of a responsive tumor may range widely. For example, in some cases, a responsive tumor may melt away, whereas in other cases, the reduction in size is not more than about 10%. Criteria for measuring responsiveness are known to skilled workers; some criteria are provided in the Examples.

[0024] The individual sequences of nucleic acids and proteins in the compositions and methods of the invention were publicly available at the time the invention was made. However, the relationship between expression of these sequences and the responsiveness of rectal adenocarcinomas to radiochemotherapy had not previously been observed; and the particular combinations of sequences in the compositions of the invention had not been disclosed or suggested.

[0025] The GenBank accession numbers and the sequences of some representative nucleic acids and proteins corresponding to genes 1-54 are provided in Table 3 (in Example II) and in the Sequence Listing attached hereto. Nucleic acids or proteins that "correspond to" a gene include nucleic acids or proteins that are expressed by the gene, or active fragments or variants of the expressed nucleic acids or proteins, or complements of the nucleic acids or fragments, etc. Only one strand of each nucleic acid is shown, but the complementary strand is understood to be included by any reference to the displayed strand. A "complement," as used herein, is a complete (full-length) complementary strand (with no mismatches) of a single strand nucleic acid.

[0026] As is discussed more fully below, probes from NCI-cDNA arrays (e.g., probes obtained from Incyte) were used in the experiments described herein to identify the 54 molecular markers of the invention. Some of those probes represent full-length coding sequences, and others (e,g,, probes corresponding to genes 3, 6, 14, 19, 28, 30, 32, 44, 45, 48 and 51) are less than full-length. Full-length nucleic acid sequences (e.g., full-length coding sequences or genomic sequences) that correspond to the less than full-length probes were obtained, using conventional methods to mine Genbank sequences. Both full-length and less than full-length sequences are listed in Table. 3. Full-length SEQ ID NOs are listed in the first column of the table; and less than full-length coding sequences in the third column. The SEQ ID NOs listed in the second column of the table in general represent full length proteins. No protein sequences are listed for some of the short EST s (e.g., genes 6, 28, 45 and 51); however, a skilled worker can readily identify open reading frames in these nucleic acid sequences and thus identify the corresponding protein sequences.

[0027] In a preferred embodiment, the nucleic acids corresponding to genes 1-54 of Table 3 are selected from the fifteen genes whose expression is most highly correlated in the study discussed herein with responsiveness of the tumors to radiochemotherapy [genes 1-12 (represented, e.g., by the nucleotide sequences of SEQ ID NOs: 1-15 and 113-114) and genes 42-44 (represented, e.g., by the nucleotide sequences of SEQ ID NOs: 46-48 and 120)]. That is, the nucleic acids in the composition (each having at least about 15 contiguous nucleotides) that correspond to genes in Table 3 may be selected from:

[0028] (a) nucleic acids that comprise sequences of SEQ ID NOs: 1-15, 113-114, 46-48, or 120;

[0029] (b) nucleic acids that comprise sequences that are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to SEQ ID NOs: 1-15, 113-114, 46-48, or 120;

[0030] (c) nucleic acids that comprise sequences encoding polypeptides represented by SEQ NOs 59-72 or 102-104;

[0031] (d) nucleic acids that comprise sequences of active fragments of the nucleic acids of (a), (b), or (c);

[0032] (e) nucleic acids that comprise sequences of active variants of the nucleic acids of (a), (b), or (c); and/or

[0033] (f) nucleic acids that comprise complete complements of any of the sequences of nucleic acids (a)-(e);

wherein the nucleic acids hybridize under conditions of high stringency to nucleic acids represented by SEQ ID NOs: 11-15, 113-114, 46-48, or 120, or to complements thereof.

[0034] The nucleic acids discussed above, arid derivatives thereof; can be used as probes to identify (e.g., by hybridization assays) polynucleotides whose expression is altered, compared to a baseline value, in rectal adenocarcinomas that are responsive to radiochemotherapy. As noted, some of the SEQ ID NOs represent full-length cDNAs, and others represent cDNAs or ESTs that are partial copies of gene coding sequences. The invention includes fragments containing sequential nucleotides of the partial or full-length cDNA s; preferably, these fragments are at least about 8, or at least about 15, nucleotides in length, and are specific for the genes from which the corresponding cDNAs were obtained. As discussed in more detail below, skilled workers will recognize how to select suitable fragments of a given nucleic acid that will hybridize specifically to a polynucleotide of interest.

[0035] Compositions of the invention may comprise any combination of, e.g., at least about 1, 2, 5, 10, 15, 20, 25, 50, 55, 60, 75 or 100 or more of the mentioned nucleic acids and/or fragments that correspond to genes from Table 3. A nucleic acid composition of the invention may comprise, consist essentially of; or consist of, a total of, e.g., about 1, 2, 5, 10, 15, 20, 25, 50, 60, 70, 100, 150, 250, 500, 750, 1,000, 2,000, 3,000, 5,000, 7,000; 8,000; 9,000; 10,000, 11,000; 12,000; 13,000; 14,000; 15,000; 25,000, 50,000, 100,000, 200,000, 500,000, 1.times.10.sup.6, or more isolated nucleic acids. The term "consisting essentially of," in this context, refers to a value intermediate between the specific number of the mentioned elements (here, nucleic acids) encompassed by the term "consisting of" and the large number encompassed by the term "comprising." A nucleic acid composition of the invention preferably comprises no more than a total of, e.g., about 1.times.10.sup.5 (e.g., no more than about 500,000; 200,000; 100,000; 50,000; 25,000; 14,000; 13,000; 12,000; 11,000; 10,000; 9,000; 8,000; 7,000; 6,000; 5,000, 4,000; 3,000; 2,000; 1,000; 750; 500; 250; 150; 100; 70; 60; 50; 25; 20; 15; 10; 5; 2; or 1) isolated nucleic acids.

[0036] Another embodiment of the invention is a composition of nucleic acids or fragments which hybridize specifically under conditions of high stringency to nucleic acids from the set represented by the SEQ ID NOs corresponding to genes 1-54 (e.g. SEQ NOs: 1-58 and 113-123), or to complements thereof.

[0037] The nucleic acid compositions of the invention may be in the form of an aqueous solution (e.g., for use in solution hybridization), or the nucleic acids in the composition may be immobilized on a substrate. In some compositions of the invention, the isolated nucleic acids are in an array or a microarray, e.g., they are hybridizable elements on an array, such as a microarray. A nucleic acid array may further comprise, bound (e.g., bound specifically) to one or more nucleic acids of the array, polynucleotides from a sample representing expressed genes. In general, as used herein, the term "nucleic acid" refers to a probe, whereas the term "polynucleotide" refers to an expression product of a gene, or a derivative of such an expression product. The sample may be, e.g., from an individual subject's rectal adenocarcinoma; from a normal tissue, such as a normal rectal tissue; from a tissue known to be non-responsive or known to be responsive to radiochemotherapy; or combinations thereof. In one embodiment, the nucleic acids in an array and the polynucleotides from a sample representing expressed genes have been subjected to nucleic acid hybridization under high stringency conditions (such that nucleic acids of the array that are specific for particular polynucleotides from the sample are specifically hybridized to those polynucleotides).

[0038] In the nucleic acid compositions of the invention, at least one phosphate, sugar and/or base moiety in the helix may be modified. For example, a phosphate may be modified as a phosphorothioate, a phosphoridothioate, a phosphoramidothioate, a phosphoramidate, a phosphordiimidate, a methylphosphonate, an alkyl phosphotriester, 3'-aminopropyl, a formacetal, or an analogue thereof.

[0039] Another embodiment is a composition comprising one or a plurality of (e.g., at least about 5, 10 or 15) isolated nucleic acids, each of which hybridizes specifically under high stringency conditions to part or all of a coding sequence whose expression reflects (is indicative of is correlated with) responsiveness of a rectal adenocarcinoma to radiochemotherapy. Examples of some such nucleic acids are nucleic acids corresponding to genes 1-54, as discussed above (e.g., nucleic acids represented by SEQ m NOs: 1-58 or 113-123, or active fragments, variants, or complements thereat).

[0040] Sequences "corresponding to" a gene, or "specific for" a gene include sequences that are substantially similar to (e.g., hybridize under conditions of high stringency to) one of the strands of the double stranded form of that gene. By hybridizing "specifically" is meant herein that two components (e.g. an expressed gene or polynucleotide and a nucleic acid probe) bind selectively to each other and not generally to other components unintended' for binding to the subject components. The parameters required to achieve specific interactions can be determined routinely, using conventional methods in the art.

[0041] Another aspect of the invention is a composition (combination) comprising polypeptides that are of a size and structure that can be recognized and/or bound by an antibody. That is, the polypeptides are antigenic. Specifically, the composition comprises one or a plurality of (e,g., at least about 5, 10 or 15) isolated, antigenic polypeptides selected from polypeptides that correspond to genes 1-54 from Table 3. For example, the composition may comprise polypeptides selected from:

[0042] (a) polypeptides comprising SEQ ID NOs: 59-112;

[0043] (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-58 or 113-123;

[0044] (c) polypeptides whose sequences are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to SEQ ID NOs: 59-112;

[0045] (d) active variants of (a), (b) or (c); and/or

[0046] (e) antigenic fragments of (a), (b) or (c),

wherein the polypeptides, active variants or antigenic fragments are of a size and structure that can be recognized, or bound by, an antibody.

[0047] In a preferred embodiment, the polypeptides in the above composition that correspond to genes from Table 3 are selected from the fifteen polypeptides whose expression is most highly correlated in the study discussed herein with responsiveness of the tumors to radiochemotherapy [genes 1-12 (represented, e.g., by the amino acid sequences of SEQ ID NOs 59-72) and genes 42-44 (represented, e.g., by the amino acid sequences of SEQ ID NOs: 102-104)]. That is, the composition may comprise polypeptides selected from:

[0048] (a) polypeptides comprising SEQ ID NOs: 59-72 or 102-104;

[0049] (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-15, 113-114, 46-48 or 120);

[0050] (c) polypeptides whose sequences are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to SEQ ID NOs: 59-72 or 102-104;

[0051] (d) active variants of (a), (b), or (c); and/or

[0052] (e) antigenic fragments of (a), (b), or (c),

wherein the polypeptides, active variants or antigenic fragments are of a size and structure that can be recognized and/or bound by an antibody.

[0053] One use of such compositions of polypeptides of the invention is as a source for generating antibodies that can be used to detect the responsiveness of a rectal adenocarcinoma to radiochemotherapy.

[0054] A composition of polypeptides of the invention may comprise any combination of, e.g., at least about 1, 2, 5, 10, 15, 25, 50, 55, 60, 75, 100 or more of the mentioned isolated polypeptides, variants or fragments that correspond to genes from Table 3. A polypeptide composition of the invention may comprise, consist essentially of or consist of e.g., at least about 1, 2, 5, 10, 15, 25, 50, 75, 100, 200, 500, 750, 1,000, 2,000, 3,000, 5,000, 10,000, 25,000, 50,000, 100,000, 200,000, 500,000, 1.times.10.sup.6, 5.times.10.sup.6 or more total isolated polypeptides.

[0055] Another embodiment is a composition comprising one or a plurality of (e.g., at least about 5, 10 or 15) isolated, antigenic, polypeptides for use in generating antibodies for detecting the response of a rectal adenocarcinoma to radiochemotherapy, wherein said polypeptides are polypeptides whose expression is correlated with responsiveness of the adenocarcinoma to radiochemotherapy.

[0056] Another aspect of the invention is a composition comprising antibodies specific for the polypeptides of the invention. As used herein, an antibody that is "specific for" a polypeptide includes an antibody that binds selectively to the polypeptide and not generally to other polypeptides unintended for binding to the antibody. The parameters required to achieve such specificity can be determined routinely, using conventional methods in the art.

[0057] One embodiment of the invention is a composition comprising selected numbers of such antibodies, which are in a form that permits their binding to the polypeptides for which they are specific. Specifically, the composition comprises one or a plurality of isolated antibodies (preferably at least about 5, 10 or 15 isolated antibodies), which are selected from antibodies that are specific for polypeptides corresponding to genes 1-54 from Table 3. Preferably, the antibodies are specific for polypeptides corresponding to genes 1-12 or 42-44 from Table 3. For example, the antibodies may be specific for polypeptides selected from:

[0058] (a) polypeptides comprising SEQ ID NOs: 59-112 (particularly SEQ ID NOs: 59-72 or 102-104);

[0059] (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-58 or 113-123 (particularly SEQ ID NOs: 1-15, 46-48, 113-114, or 120);

[0060] (c) polypeptides that are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to SEQ ID NOs: 59-112 (particularly to SEQ ID NOs: 59-72 or 102-104);

[0061] (d) polypeptides that are active variants of (a), (b), or (c); and/or

[0062] (e) polypeptides that are antigenic fragments of (a), (b) or (c).

[0063] Generally, the antigenic fragments comprise at least about 8 or at least about 12 contiguous amino acids of said polypeptide sequences.

[0064] The antibody compositions of the invention may be used, e.g., to determine the responsiveness of a rectal adenocarcinoma to radiochemotherapy.

[0065] The above compositions may comprise any combination of, e.g., at least about 1, 2, 5, 10, 15, 20, 25, 35, 45, 55, 65, 75, 100, 200, 300, 400, 500 or more of the mentioned isolated antibodies or antibody fragments specific for genes that correspond to genes from Table 3. An antibody composition of the invention may comprise, consist essentially of, or consist of a total of, e.g., at least about 1, 2, 5, 10, 15, 20, 25, 50, 60, 70, 100, 125, 150, 200, 250, 300, 400, 500, 750, 1,000, 2,000, 3,000, 5,000, 7,000; 8,000; 9,000; 10,000, 11,000; 12,000; 13,000; 14,000; 15,000; 25,000, 50,000, 100,000, 200,000, 500,000, 1.times.10.sup.6 or more isolated antibodies. In embodiments of the invention, the composition comprises no more than about 1,000 (e.g., no more than about 500,000; 200,000; 100,000; 50,000; 25,000; 14,000; 13,000; 12,000; 11,000; 10,000; 9,000; 8,000; 7,000; 6,000; 5,000, 4,000; 3,000; 2,000; 1,000; 750; 500; 400; 300; 250; 200; 150; 125; 100; 70; 60; 50; 25; 20; 15; 10; 5; 2; or 1) total isolated antibodies.

[0066] The isolated antibodies in any of the above compositions may be in the form of an aqueous solution (e.g., in a form suitable for radioimmunoassay), or the isolated antibodies may be immobilized on a substrate. In embodiments of the invention, the isolated antibodies are in an array, e.g., a microarray; they may be reactive elements on an array, such as a microarray. By "reactive" elements is meant that the antibodies can react, e.g., bind, in a specific manner, with antigens for which they are specific.

[0067] Another aspect of the invention is a method for detecting (e.g., measuring, or quantitating) one or more polynucleotides or polypeptides of the invention in a sample, such as a sample from a rectal adenocarcinoma, compared to a baseline value. Generally, the detected polynucleotides or polypeptides correspond to a gene whose expression is correlated with responsiveness of the tumor to radiochemotherapy (e.g., genes 1-54 from Table 3). The method is generally a method for determining the responsiveness of the rectal adenocarcinoma to radiochemotherapy. In one embodiment, this method involves contacting the sample with a composition of nucleic acids, or of antibodies, of the invention, under conditions effective for specific binding of the nucleic acids to the polynucleotides in the sample (such as hybridization under conditions of high stringency), or effective for specific binding of the antibodies to the polypeptides in the sample. The method may further comprise detecting (e.g., determining the amount of) the polynucleotides in the sample which have bound to the nucleic acids, or detecting (e.g., determining the amount of) the polypeptides in the sample which have bound to the antibodies. Preferably, the polynucleotides or polypeptides that are detected reflect expression (either up-regulation or down-regulation) that is correlated with (indicative of) responsiveness of the adenocarcinoma to radiochemotherapy.

[0068] For example, a decrease in the amount (level of expression) of one or more of set #1 of 41 polynucleotides or polypeptides in a sample indicates that the adenocarcinoma is responsive to radiochemotherapy. Set #1 comprises nucleic acids corresponding to genes 1-41 (e.g., nucleic acids that comprise SEQ ID NOs: 145 or 113-119, or that can hybridize specifically (e.g., under conditions of high stringency) to those nucleic acids, or that are complements of those nucleic acids, etc.); and the corresponding polypeptides, which comprise sequences corresponding to genes 1-41 (e.g., polypeptides comprising SEQ ID NOs: 59-102, etc.).

[0069] An increase in the amount (level of expression) of one or more of set #2 of 13 polynucleotides or polypeptides in a sample indicates that the adenocarcinoma is responsive to radiochemotherapy. Set #2 comprises nucleic acids corresponding to genes 42-54 (e.g., nucleic acids that comprise SEQ ID NOs: 46-58 or 120-123, or that can hybridize specifically (e.g., under conditions of high stringency) to those nucleic acids, or that are complements of those nucleic acids, etc.); and the corresponding polypeptides, which comprise sequences corresponding to genes 42-54 (e.g., polypeptides comprising SEQ ID NOs: 102-112, etc.).

[0070] In assays described herein, a given polynucleotide or polypeptide may or may not be expressed in an increased or decreased amount in a sample from a rectal adenocarcinoma, compared to a baseline value. In a general sense, this invention relates to methods to determine if a gene product is expressed in an increased or decreased amount, irrespective of whether such increased or decreased expression is detected.

[0071] The rectal adenocarcinoma evaluated in this method is preferably from a human patient. The patient may not have been subjected to surgery, such as rectal resection, i.e., the patient is preoperative. In this case, the method can provide information as to Whether preadjuvant therapy is advisable. Alternatively, the patient may have already been subjected to surgery, such as rectal resection, i.e., the patient is postoperative. In this case, the method can provide information as to whether adjuvant therapy is advisable.

[0072] In one embodiment, the method comprises determining in a polynucleotide sample which represents expressed genes in a rectal adenocarcinoma the amount (level of expression), compared to a baseline value, of one or a plurality of (e.g., at least about 5, 10 or 15) polynucleotides whose expression is correlated with the responsiveness of the adenocarcinoma to radiochemotherapy. For example, the expression of genes selected from genes 1-54 of Table 3 can be measured. As used herein, the term "polynucleotide" sample in general refers to expression products of genes, such as mRNA, or derivatives of such expression products, such as, e.g., cRNA, cDNA, or PCR amplification products. The term "nucleic acid" generally refers to a nucleic acid used as a probe to detect such polynucleotides.

[0073] In one embodiment of this method, each of the polynucleotides can hybridize specifically (e.g., under conditions of high stringency) to one of the nucleic acids noted above. For example, the nucleic acids may be selected from nucleic acids comprising SEQ ID NOs: 1-58 or 113-123 (in particular, SEQ ID NOs: 1-15, 46-48, 113-114, or 120), and/or the mentioned fragments or variants thereof (e.g., nucleic acids that are at least about 90%, 95% or 98% identical to those SEQ ID NOs; nucleic acids that encode polypeptides represented by SEQ ID NOs: 59-112 (in particular, SEQ ID NOs: 59-72 or 102-104); active fragments that comprise at least about 8 to 15 contiguous nucleotides of any of those nucleic acids; active variants of any of those nucleic acids; or complements of any of the above nucleic acids). In embodiments of this method, the amount (level of expression) of at least about 1, 2, 5, 10, 25, 50, or 54 of the polynucleotides corresponding to genes 1-54 from Table 3 is determined,

[0074] In one embodiment of the method, the amount (level of expression) of polynucleotides in a sample is determined by hybridizing polynucleotides in the sample to a nucleic acid composition of the invention, under conditions of high stringency, and comparing the amount of hybridization to a baseline value. In embodiments of this method, the nucleic acids are immobilized on a substrate, and/or are in an array, e.g. are hybridizable elements on an array, such as a microarray.

[0075] The amount of hybridization of a polynucleotide in the sample to a nucleic acid specific for it in the nucleic acid composition generally reflects the level of expression of the polynucleotide in the rectal adenocarcinoma.

[0076] The baseline value may be obtained, for example, by hybridizing a nucleic acid composition of the invention, under conditions of high stringency, to a control polynucleotide sample. For example, one can use a polynucleotide sample obtained from normal tissue, such as a normal rectal tissue, e.g. from the subject or from a "pool" of normal subjects; or to a polynucleotide obtained from a pool of different tissues of normal subjects. In a preferred embodiment, one uses a pool of cell lines of carcinogenic origin, such as the universal human reference library available from Stratagene (catalogue no. 740000). The pooled values may be either commercially available or otherwise derived. Alternatively, the baseline value may be the expression in rectal carcinomas that are known to be "non-responders" to radiochemotherapy, e.g., the average value from a pool or compilation of such tumor samples. Any of the above types of baseline values may available in a database compiled from such values.

[0077] In another embodiment of this method, the determination of the amount (level of expression) of polynucleotides in a sample is performed by quantitatively amplifying polynucleotides in the rectal adenocarcinoma sample with primers specific for those polynucleotides, and comparing the amount of amplified polynucleotide to a baseline value. For example, conventional methods of RT-PCR may be used. In one embodiment, the polynucleotides from the rectal adenocarcinoma sample (and, optionally, from controls) are labeled with a detectable label, e.g., a fluorescent label.

[0078] In another embodiment, the method comprises determining in a polypeptide sample from a rectal adenocarcinoma the amount (level of expression), compared to the amount (level of expression) of a baseline value, of each of one or a plurality of polypeptides whose expression is correlated with the responsiveness of the adenocarcinoma to radiochemotherapy (e.g., polypeptides corresponding to genes 1-54 of Table 3). The polypeptides may be selected from polypeptides that bind specifically to antibodies specific for polypeptides:

[0079] (a) comprising SEQ ID NOs: 59-112 (particularly SEQ ID NOs; 59-72 or 102-104);

[0080] (b) encoded by polynucleotides comprising SEQ ID NOs: 1-58 and 113-123 (particularly SEQ ID NOs: 1-15, 46-48, 113-114, and 120);

[0081] (c) whose sequences are at least about 85% (e.g., at least about 90%, 95%, or 98%) identical to SEQ ID NOs: 59-112 (particularly to SEQ ID NOs: 59-72 and 102-104);

[0082] (d) that are active variants of (a), (b), or (c); and/or

[0083] (e) that are antigenic fragments of (a), (b) or (c).

[0084] An altered amount (level of expression) of one or more of the polypeptides compared to a baseline value is correlated with the responsiveness of the rectal adenocarcinoma to radiochemotherapy. In embodiments of the invention, the amount of at least about 1, 2, 5, 10, 50 or 54 of the polypeptides is determined.

[0085] In one embodiment of this method, the determination is performed by:

[0086] contacting said polypeptide sample with an antibody composition containing one or a plurality of antibodies specific for polypeptides comprising polypeptides (a), (b), (c), (d) and/or (e) above, under conditions effective for at least one of said antibodies to bind specifically to the corresponding polypeptide (polypeptide for which it is specific), and

[0087] comparing the amount (degree) of specific binding of to a baseline value.

[0088] The antibody composition may be in the fern of an aqueous solution; the antibodies may be immobilized on a substrate or surface (e.g., a surface suitable for surface plasmon resonance (SPR)-based technology); and/or the antibodies may be in an array, e.g. they may be reactive elements on an array, such as a microarray.

[0089] The amount of binding of a polypeptide in the sample to an antibody specific for it in the antibody composition generally reflects the amount (level of expression) of the polypeptide in the rectal adenocarcinoma.

[0090] The baseline value may reflect the amount of the polypeptides expressed in nomad tissue. For example, it may he obtained by contacting the antibody composition, under conditions as above, to a polypeptide sample obtained from normal rectal tissue, e.g., from the subject or a reference "pool" of normal subjects; or to a polypeptide sample obtained from a pool of different tissues of normal subjects. In a preferred embodiment, one uses a pool of cell lines of carcinogenic origin, such as the universal human reference library available from Stratagene (catalogue no. 740000). The pooled values may be either commercially available or otherwise derived. Alternatively, the baseline value may be determined with rectal carcinomas that are known to be "non-responders" to radiochemotherapy, e.g., the average value from a pool or compilation of such tumor samples. Any of the above types of baseline values may available in a compiled database.

[0091] Another aspect of the invention is a kit (e.g. for detecting the presence and/or amount of a polynucleotide in a sample from a rectal adenocarcinoma, which may indicate that the rectal adenocarcinoma is responsive to radiochemotherapy), comprising a composition of nucleic acids of the invention (e.g., in the form of an array) and, optionally, one or more reagents that facilitate hybridization of the nucleic acids in the composition to a test polynucleotide(s) of interest, and/or that facilitate detection of the hybridized polynucleotide(s), e.g., that facilitate detection of fluorescence. The kit may comprise a composition of nucleic acids of the invention (e.g., in the form of an array), means for carrying out hybridization of the nucleic acids in the composition to a test polynucleotide(s) of interest, and/or for means for reading hybridization results. Hybridization results may be units of fluorescence.

[0092] Another aspect is a kit (e.g. for detecting the presence and/or amount of a polypeptide in a sample from a rectal adenocarcinoma, which may indicate that the rectal adenocarcinoma is responsive to radiochemotherapy), comprising a composition of antibodies of the invention (e.g., in the form of an array) and, optionally, one or more reagents that facilitate binding of the antibodies in the composition with a test polypeptide(s) of interest, or that facilitate detection of bound antibody. The kit may comprise a composition of antibodies of the invention (e.g., in the form of an array), means for carrying out binding of the antibodies in the array to a test polynucleotide(s) of interest, and/or means for reading the binding results.

[0093] Another aspect of the invention is a method for identifying a candidate for an agent (e.g., a drug) that enhances (e.g., facilitates, increases, potentiates) the response of a rectal adenocarcinoma to radiochemotherapy. Such an agent would be particularly valuable if administered to a patient in conjunction with radiochemotherapy. One embodiment of this method comprises

[0094] (a) contacting a rectal adenocarcinoma cell with a putative agent;

[0095] (b) hybridizing a sample of polynucleotides representing expressed genes obtained from the contacted adenocarcinoma cell to a nucleic acid composition of the invention, under conditions effective for specific hybridization of a nucleic acid probe of the invention to its corresponding polynucleotide target (e.g., under high stringency hybridization conditions); and

[0096] (c) determining the amount (level of) of specific hybridization of one or more of the polynucleotides in the sample to one or more of the nucleic acids in the composition, compared to the amount in the absence of the putative agent,

[0097] wherein the amount of specific hybridization of a polynucleotide reflects the amount (level) of its expression in the contacted adenocarcinoma cell, and

[0098] wherein a putative agent that reduces the expression of one or more polynucleotides of the invention corresponding to genes 1-41, or that enhances the expression of one or more polynucleotides of the invention corresponding to genes 42-54, compared to the amount in the absence of the putative agent, is a candidate for an agent that enhances the response of a rectal adenocarcinoma to radiochemotherapy. The method may further comprise assessing the ability of the candidate agent to enhance responsiveness of an adenocarcinoma to radiochemotherapy in viva.

[0099] Another aspect of the invention is a method for identifying a candidate for an agent (e.g., a drug) that enhances the response of a rectal adenocarcinoma to radiochemotherapy, comprising,

[0100] (a) contacting a rectal adenocarcinoma cell with a putative agent;

[0101] (b) contacting a sample of polypeptides obtained from the contacted adenocarcinoma cell with an antibody composition of the invention, under conditions effective for specific binding of an antibody to its corresponding polypeptide; and

[0102] (c) determining the amount (level of) of specific binding of one of more of the polypeptides in the sample to one of more of the antibodies of the composition, compared to the amount in the absence of the putative agent,

[0103] wherein the amount of specific binding of a polypeptide reflects the amount (level) of its expression in the contacted adenocarcinoma, and

[0104] wherein a putative agent that reduces the expression of one or more polypeptides of the invention corresponding to genes 1-41, or that enhances the expression of one or more polynucleotides of the invention corresponding to genes 42-54, compared to the amount in the absence of the putative agent, is a candidate for an agent that enhances the response of a rectal adenocarcinoma to radiochemotherapy. The method may further comprise assessing the ability of the candidate agent to enhance responsiveness of an adenocarcinoma to radiochemotherapy in viva,

[0105] Another aspect of the invention is a method for identifying target genes for therapy of rectal adenocarcinoma.

[0106] One embodiment is a method for identifying a gene whose inhibition (of expression or activity) enhances the response of a rectal adenocarcinoma to radiochemotherapy, comprising

[0107] (a) inhibiting in a rectal adenocarcinoma the expression and/or activity of a gene selected from genes 1 through 41, or the expression and/or activity of a gene product of one of those genes; and

[0108] (b) determining if the rectal tumor exhibits an increased response to radiochemotherapy compared to a baseline value.

[0109] Another embodiment is a method for identifying a gene whose stimulation (of expression or activity) enhances the response of a rectal adenocarcinoma to radiochemotherapy, comprising

[0110] (a) stimulating in a rectal adenocarcinoma the expression and/or activity of a gene selected from genes 42 through 54, or the expression and/or activity of a gene product of one of those genes; and

[0111] (b) determining if the rectal tumor exhibits an increased response to radiochemotherapy compared to a baseline value.

[0112] In the present application, the term "nucleic acid" (e.g., with reference to probe molecules) refers both to DNA (including cDNA) and RNA, as well as DNA-like or RNA-like materials, such as branched DNAs, peptide nucleic acids (PNA) or locked nucleic acids (LNA). Nucleic acid probes for gene expression analysis include those comprising ribonucleotides, deoxyribonucleotides, both, and/or their analogues. Nucleic acids of the invention include double stranded and partially or completely single stranded molecules. In a preferred embodiment, probes for gene expression comprise single stranded nucleic acid molecules that are complementary to an mRNA target expressed by a gene of interest, or that are complementary to the opposite strand (e.g., complementary to a first strand cDNA generated from the mRNA).

[0113] Several nucleic acid probe sequences described herein are cDNAs complementary to genes or gene fragments; some are ESTs. For purposes of the analysis, it is not necessary that the Pall length sequence be known, as those of skill in the art will know how to obtain the full length sequence using the sequence of a given fragment or EST and known data mining, bioinformatic, and DNA sequencing methodologies without undue experimentation. If desired, the skilled artisan can subsequently select as a probe a nucleic acid that is longer than the initial gene fragment or EST, or a suitable fragment selected from that extended sequence. Many full length sequences (e.g., full-length coding sequences or genomic sequences) have been determined from less than full-length sequences used in the experiments described herein; these full length sequences are provided in Table 3, Again, a skilled worker can readily select suitable probe sequences, corresponding to coding sequences, using conventional procedures. Since some of the probe sequences are identified solely based on expression levels, it is not essential to know a priori the function of a particular gene.

[0114] The present invention includes a variety of active variants of nucleic acids. For example, nucleic acid probes can be sequence variants of the sequences described herein (e.g., they can include nucleotide substitutions, small insertions or deletions, nucleotide analogues, etc.); or they can be chemical variants (e.g., they can contain chemical derivatives); or they can be length variants. An "active variant," as used herein, is a variant that retains a measurable amount of an activity of the starting material. For example, an active variant of a nucleic acid probe retains an adequate ability to hybridize specifically to a complementary DNA strand (or mRNA) in a test sample. Preferably, an active variant of a nucleic acid probe also exhibits adequate resistance to nucleases and stability in the hybridization protocols employed. DNA or RNA may be made more resistant to nuclease degradation, e.g., by incorporating modified nucleosides (e.g., 2'-O-methylribose or 1'-.alpha.-anomers), or by modifying internucleoside linkages (e.g., methylphosphonates or phosphorothioates), as described below.

[0115] With regard to sequence variants, the invention includes nucleic acid probes which exhibit variations in sequence compared to the wild type sequence, provided the probe retains the ability to hybridize specifically to the polynucleotide to which it corresponds (e.g., to the nucleic acid from which it is derived, or a complement thereof). For example, small deletions, insertions, substitutions, rearrangements etc. are tolerated. The sequence changes may be introduced artificially, or they may be naturally occurring, e.g., changes reflecting degeneracy of the genetic code, allelic variants, species homologues, etc.

[0116] Nucleotide analogues can be incorporated into the nucleic acids by methods well known in the art. The only requirement is that the incorporated nucleotide analogues must serve to base pair with target polynucleotide sequences. For example, certain guanine nucleotides can be substituted with hypoxanthine which base pairs with cytosine residues. However, these base pairs are less stable than those between guanine and cytosine. Alternatively, adenine nucleotides can be substituted with 2,6-diaminopurine which can form stronger base pairs than those between adenine and-thymidine.

[0117] The invention also relates to nucleic acid probes that are at least about 70%, 75%, 80%, 85%, 90%, 95%, 98% or 99% identical in sequence to a polynucleotide target of interest, or to a complement thereof. The invention also relates to nucleic acid probes that are at least about 70%, 75%, 80%, 85%, 90%, 95%, 98% or 99% identical or complementary to one of the nucleic acids of the invention corresponding to genes 1-54. Conventional algorithms can be used to determine the percent identity or complementarity, e.g., as described by Lipman and Pearson (Proc. Natl Acad Sci 80:726-730, 1983) or Martinez/Needleman-Wunsch (Nucl Acid Research 11:4629-4634, 1983).

[0118] The invention also relates to nucleic acid probes that hybridize specifically to corresponding target polunucleotides, e.g., under conditions of high stringency. Hybridization condtions are discussed elsewhere herein. Some nucleic acid probes may not hybridize effectively under hybridization conditions due to secondary structure. To optimize probe hybridization, the probe sequences may be examined using a computer algorithm to identify portions of genes without potential secondary structure. Such computer algorithms are well known in the art, such as OLIGO 4.06 Primer Analysis Software (National Biosciences, Plymouth, Minn.) or LASERGENE software (DNASTAR, Madison, Wis); MACDASLS software (Hitachi Software Engineering Co, Std. South San Francisco, Calif.) and the like. These programs can search nucleotide sequences to identify stem loop structures and tandem repeats and to analyze G+C content of the sequence (those sequences with a G+C content greater than 60% are excluded). Alternatively, the probes can be optimized by trial and error. Experiments can be performed to determine whether probes and complementary target polynucleotides hybridize optimally under experimental conditions.

[0119] With regard to chemical variants, the nucleic acids can include nucleotides that have been derivatized chemically or enzymatically. Typical chemical modifications include derivatization with acyl, alkyl, aryl or amino groups. Suitable modified base moieties include, for example, 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl)uracil, 5-carboxymethylaminomethyl-.omega.-thiouridine, 5-carboxymethyl-aminomethyl uracil, dihydrouracil, .beta.-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 3-methyl-cytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, .beta.-D-mannosylqueosine, 5-methoxy-carboxymethyluracil, 5-methoxyuracil-2-methylthio-N6-iso-pentenyladenine, uracil-5-oxyacetic acid, butoxosine, pseudouracil, queuosine, 2-thio-cytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-t-oxyacetic acid, 5-methyl-2-thiouracil, 3(3-amino-3-N-2-carboxypropyl)uracil and 2,6-diaminopurine.

[0120] The nucleic acid may comprise at least one modified sugar moiety including, but not limited, to arabinose, 2-fluoroarabinose, xylulose, and hexose.

[0121] The nucleic acid may comprise a modified phosphate backbone synthesized from one or more nucleotides having, for example, one of the following structures; a phosphorothioate, a phosphoridothioate, a phosphoramidothioate, a phosphoramidate, a phosphordiimidate, a methylphosphonate, an alkyl phosphotriester, 3'-aminopropyl and a form acetal or analog thereof.

[0122] The nucleic acid may be an .alpha.-anomeric oligonucleotide which forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual .beta.-units, the strands run parallel to each other (Gautier et al. (1987), Nucl. Acids Res. 15:6625-6641).

[0123] The nucleic acid may be conjugated to another molecule, e.g., a peptide, a hybridization-triggered cross-linking agent, a hybridization-triggered cleavage agent, etc., all of which are well-known in the art.

[0124] With regard to length variants (active fragments), those skilled in the art will appreciate that a probe of choice for a particular gene can be the full length coding sequence or any fragment thereof having generally at least about 8 or at least about 15 nucleotides. When the full length sequence is known, the practitioner can select any appropriate fragment of that sequence, using conventional methods. In some embodiments, multiple probes, corresponding to different portions of a given SEQ ID (molecular marker) of the invention, are used. For example, probes representing about 10 non-overlapping 20-mers can be selected from a 200-mer sequence. Thus, for example, if each of the 54 molecular markers of the invention is represented by 10 probes, the total number of the probes corresponding to the molecular markers in the composition (e.g., in a microarray) will be 540. A skilled worker can design a suitable selection of overlapping or non-overlapping probes corresponding to each expressed polynucleotide of interest, without undue experimentation.

[0125] A nucleic acid probe of the invention can be of any suitable length. The size of the DNA sequence of interest may vary, and is preferably from about 8 to about 10,000 nucleotides, e.g. from about 50 to about 3,500 nucleotides. In some embodiments, full-length coding sequences are preferred. In others, the nucleic acids range from about 50 to about 200 nucleotides, preferably from about 50 to about 80 nucleotides. All ranges provided herein include the end point values. Any nucleic acid that can uniquely identify a polynucleotide of the invention (e.g., that can hybridize to it specifically) is included in the invention. In general, a nucleic acid comprising at least about 8, 10, 15, 20 or 25 or more contiguous nucleotides contains sufficient information to specify uniquely a gene of a mammalian (e.g., human) genome. Practically, larger oligonucleotides are generally used as probes.

[0126] Nucleic acid probes (e.g., oligonucleotides) of this invention may be synthesized, in whole or in part, by standard synthetic methods known in the art. See, e.g., Caruthers et al. (1980) Nucleic. Acids Symp. Ser. (2) 215-233; Stein et al. (1998), Nucl. Acids Res. 16, 3209; and Sarin et al, (1988), Proc. Natl. Acad. Sci. USA 85, 7448-7451. An automated synthesizer (such as those commercially available from Biosearch, Applied Biosystems) may be used. DNA probes can be cloned and isolated by conventional methods; can be isolated from pre-existing clones, such as those from Incyte as described herein; or can be prepared by a combination of conventional synthetic methods.

[0127] A composition comprising nucleic acids of the invention can take any of a variety of forms. For example, the nucleic acids can be fi-e in a solution (e.g., an aqueous solution), and can, e.g., be subjected to hybridization in solution to polynucleotides from a sample of interest. Methods of hybridization in solution are well-known in the art.

[0128] Alternatively, the nucleic acids can be in the final of an array. The term "array" as used herein means an ordered arrangement of addressable, accessible, spatially discrete or identifiable, molecules disposed on a surface. The molecules in the array can be hybridizable elements (e.g., nucleic acids) or reactive elements (e.g., antibodies). Arrays can comprise any number of sites that comprise probes, from about 5 to, in the case of a microarray, tens to hundreds of thousands or more.

[0129] Any of a variety of suitable, compatible surfaces can be used in conjunction with this invention. The surface (usually a solid, preferably a suitable rigid or semi-rigid support) can be any of a variety of organic or inorganic materials or combinations thereof, including, merely by way of example, plastics such as polypropylene or polystyrene; ceramic; silicon; (fused) silica, quartz or glass, which can have the thickness of, for example, a glass microscope slide or a glass cover slip; paper, such as filter paper; diazotized cellulose; nitrocellulose filters; nylon membrane; or polyacrylamide gel pad. Substrates that are transparent to light are useful when the method of performing an assay involves optical detection. Suitable surfaces include membranes, filters, chips, slides, wafers, fibers, magnetic or nomnagnetic beads, gels, tubing, plates, polymers, microparticles, capillaries, or the like. The substrate can have a variety of surface forms, such as wells, trenches, pins, channels and pores, to which the nucleic acid probes are bound. The shape of the surface is not critical. It can, for example, be a flat surface such as a square, rectangle, or circle; a curved surface; or a three dimensional surface such as a bead, particle, strand, precipitate, tube, sphere, etc. Microfluidic devises are also encompassed by the invention.

[0130] In a preferred embodiment, a composition of nucleic acids is in the form of a microarray (sometimes referred to as a DNA "chip"). Microarrays allow for massively parallel gene expression analysis. See, e.g., Lockhart et at (2002), Nature 405, 827-836 and Phimister (1999), Nature Genetics 21(supp), 1-60. In a microarray, the array elements are arranged so that there are preferably at least one or more different array elements, more preferably at least about 100 array elements, and most preferably at least about 1,000 array elements, on a 1 cm.sup.2 substrate surface. The maximum number of array elements is unlimited, and can be at least 100,000 array elements. Furthermore, the hybridization signal ham each of the array elements is individually distinguishable. Methods of making DNA arrays, including microarrays are conventional. For example, the probes may be synthesized directly on the surface; or preformed molecules, such as oligonucleotides or cDNAs, may be introduced onto (e.g., bound to, or otherwise immobilized on) the surface. Among suitable fabrication methods are photolithography, pipetting, drop-touch, piezoelectric printing (ink-jet), or the like. For some typical methods, see Ekins et al. (1999), Trends in Biotech 17, 217-218; Healey et al. (1995) Science 269, 1078-80; WO95/251116; WO95/35505; and U.S. Pat. No. 5,605,662.

[0131] Furthermore, the probes do not have to be directly bound to the substrate, but rather can be bound to the substrate through a linker group. The linker groups are typically about 6 to 50 atoms long to provide exposure to the attached nucleic acid probe. Preferred linker groups include ethylene glycol oligomers, diamines, diacids and the like. Reactive groups on the substrate surface react with one of the terminal portions of the linker to bind the linker to the substrate. The other terminal portion of the linker is then functionalized for binding the nucleic acid probe.

[0132] A composition of the invention may comprise, optionally, nucleic acids (or polypeptides, or antibodies) that act as internal controls. The controls may he positive controls or negative controls, examples of which will be evident to the skilled worker. in order to conduct an analysis of expressed genes, a sample representing expressed target genes (polynucleolides or polypeptides) is first derived from a rectal adenocarcinoma. As used herein, "polynucleotides" refers to a target whose expression is analyzed, whereas "nucleic acid" refers to a composition (of probes) used to analyze the expression of the polynucleotides. The sample can be derived from any bodily fluid (blood, urine, saliva, phlegm, gastric juices, etc.), from stool samples, or from cultured cells. Preferably, the sample is derived from rectal biopsy tissue. Because rectal adenocarcinoma cells can also he present in peripheral blood, blood samples may also be used.

[0133] DNA or RNA can be isolated according to any of a number of methods well known to those of skill in the art. For example, methods of purification of nucleic acids are described in Laboratory Techniques in Biochemistry and Molecular Biology: Hybridization With Nucleic Acid Probes, Part I. Theory and Nucleic Acid Preparation, P. Tijssen, ed. Elsevier, New York, N.Y. (1993). In one case, total RNA is isolated using the TRIZOL total RNA isolation reagent (Life Technologies, Gaithersburg, Md.) and mRNA is isolated using oligo d(T) column chromatography or glass beads. Alternatively, when target polynucleotides are derived from an mRNA, the target polynucleotide can he a eDNA reverse transcribed from an mRNA, an RNA transcribed from that cDNA, a DNA amplified from that eDNA, an RNA transcribed from the amplified DNA, or the like. When the target polynucleotide is derived from DNA, the target polynucleotide can be DNA amplified from DNA or RNA reverse transcribed from DNA. In yet another alternative, the targets are target polynucleotides prepared by more than one method. Accordingly, a polynucleotide sample "representing expressed genes" can comprise, e.g., mRNA, cRNA, cDNA, PCR products, or the like.

[0134] When target polynucleotides are amplified it is desirable to amplify the polynucleotide and maintain the relative abundances of the original sample, including low abundance transcripts. Total mRNA can be converted to cDNA and amplified by conventional procedures. For example, in one embodiment, mRNA is amplified by reverse transcription using a reverse transcriptase and a primer consisting of oligo d(T) and a sequence encoding the phage T7 promoter to provide a single stranded DNA template. The second cDNA strand is polymerized using a DNA polymerase and a RNAse which assists in breaking up the DNA/RNA hybrid. After synthesis of the double stranded cDNA, T7 RNA polymerase can be added and RNA transcribed from the second eDNA strand template (Van Gelder et al. U.S. Pat. No. 5,545,522). RNA can be amplified in vitro, in situ or in viva (See Eberwine, U.S. Pat. No. 5,514,545). A cDNA may be amplified by any of a variety of conventional amplification procedures, including PCR. Suitable PCR primers can be selected using routine, any-recognized methods. For guidance with regard to designing suitable primers and other facets of PCR methodology, see hints et al. eds. PCR Protocols: a guide to methods and applications, 1990, Academic Press, San Diego, Calif. or other standard references or manuals.

[0135] It is advantageous to include quantitation controls within the sample to assure that amplification and labeling procedures do not change the true distribution of target polynucleotides in a sample. For this purpose, a sample can be spiked with a known amount of a control target polynucleotide and the composition of nucleic acid probes can include reference nucleic acid probes which specifically hybridize with the control target polynucleotides. After hybridization and processing, the hybridization signals obtained should reflect accurately the amounts of control target polynucleotide added to the sample.

[0136] Prior to hybridization, it may be desirable to :fragment the target polynucleotides. Fragmentation improves hybridization by minimizing secondary structure and cross-hybridization to other nucleic acid target polynucleotides in the sample or noncomplementary nucleic acid probes. Fragmentation can be performed by mechanical, enzymatic or chemical means.

[0137] The target polynucleotides may be labeled with one or more labeling moieties to allow for detection of hybridized probe/target polynucleotide complexes. The labeling moieties can include compositions that can be detected by spectroscopic, photochemical, biochemical, bioelectronic, immunochemical, electrical, optical or chemical means. The labeling moieties include radioisotopes, such as .sup.32P, .sup.33P or .sup.35S, chemiluminescent compounds, labeled binding proteins, heavy metal atoms, spectroscopic markers, such as fluorescent markers and dyes, magnetic labels, linked enzymes, mass spectrometry tags, spin labels, electron transfer donors and acceptors, and the like. In a preferred embodiment, a fluorescent dye is incorporated directly by using a fluorochrome conjugated nucleotide triphosphate (e.g. Cy3-dUTP) or through a secondary coupling reaction by first incorporating an amino allyl conjugated nucleotide triphosphate (e.g. amino allyl-dUTP) followed by chemical coupling of the fluorochrome (e.g. NHS-Cy3).

[0138] Exemplary dyes include quinoline dyes, triarylmethane dyes, phthaleins, azo dyes, cyanine dyes and the like. Preferably, fluorescent markers absorb light above about 300 nm, preferably above 400 nm, and usually emit light at wavelengths at least greater than 10 nm above the wavelength of the light absorbed. Specific preferred fluorescent markers include fluorescein, phycoerythrin, rhodamine, lissamine, and Cy3 and Cy5 available from Amersham Pharmacia Biotech (Piscataway, N.J.).

[0139] Labeling can be carried out during an amplification reaction, such as polymerase chain and in vitro transcription reactions, or by nick translation or 5' or 3'-end-labeling reactions. In one case, labeled nucleotides are used in an in vitro transcription reaction. When the label is incorporated after or without an amplification step, the label is incorporated by using terminal transferase or by kinasing the 5' end of the target polynucleotide and then incubating overnight with a labeled oligonucleotide in the presence of T4 RNA ligase.

[0140] Alternatively, the labeling moiety can be incorporated after hybridization once a probe/target complex has formed. In one case, biotin is first incorporated during an amplification step as described above. After the hybridization reaction, unbound polynucleotides are rinsed away so that the only biotin remaining bound to the substrate is that attached to target polynucleotides that are hybridized to the nucleic acid probes. Then, an avidin-conjugated fluorophore, such as avidin-phycoerythrin, that binds with high affinity to biotin is added. In another case, the labeling moiety is incorporated by intercalation into preformed target/polynucleotide probe complexes. In this case, an intercalating dye such as a psoralen-linked dye can be employed.

[0141] Under some circumstances it may be advantageous to immobilize the target polynucleotides on a substrate and have the nucleic acid probes bind to the immobilized target polynucleotides. In such cases the target polynucleotides can be attached to a substrate as described above.

[0142] Hybridization causes a denatured nucleic acid probe and a denatured complementary target polynucleotide to form a stable duplex through base pairing. Hybridization methods are well known to those skilled in the art (See, for example, Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 24: Hybridization With Nucleic Acid Probes, P. Tijssen, ed. Elsevier, New York, N.Y. (1993)). Conditions can be selected for hybridization where exactly complementary target and nucleic acid probe can hybridize, i.e., each base pair must interact with its complementary base pair. Alternatively, conditions can be selected where target and probes have mismatches but are still able to hybridize. Suitable conditions can be selected, for example, by varying the concentrations of salt or formamide in the prehybridization, hybridization and wash solutions, or by varying the hybridization and wash temperatures.

[0143] Hybridization can be performed at low stringency with buffers, such as 6.times. SSPE with 0.005% Triton X-100 at 37.degree. C., which permits hybridization between target and polynucleotide probes that contain some mismatches to form target polynucleotide/probe complexes. Subsequent washes are performed at higher stringency with buffers, such as 0.5.times.SSPE with 0.005% Triton X-100 at 50.degree. C., to retain hybridization of only those target/probe complexes that contain exactly complementary sequences. Alternatively, hybridization can be performed with buffers, such as 5.times.SSC/0.2% SDS at 60.degree. C., and washes performed in 2.times.SSC/0.2% SDS and then in 0.1.times.SSC. Stringency can also be increased by adding agents such as formamide. Background signals can be reduced by the use of detergent, such as sodium dodecyl sulfate, Sarcosyl or Triton X-100, or a blocking agent, such as sperm DNA or bovine serum albumin (BSA).

[0144] In a preferred embodiment, nucleic acid probes of the invention hybridize specifically to target polynucleotides of interest under conditions of high stringency. As used herein, "conditions of high stringency" or "high stringent hybridization conditions" means any conditions in which hybridization will occur when there is at least about 95%, preferably about 97 to 100%, nucleotide complementarity (identity) between the nucleic acids (e.g., a polynucleotide of interest and a nucleic acid probe). Generally, high stringency conditions are selected to be about 5.degree. C. to 20.degree. C. lower than the thermal melting point (T.sub.m) for the specific sequence at a defined ionic strength and pH. Appropriate high stringent hybridization conditions include, e.g., hybridization in a buffer such as, for example, 6.times. SSPE-T (0.9 M NaCl, 60 mM NaH, PO.sub.4, 6 mM EDTA and 0.05% Triton X-100) for between about 10 minutes and about at least 3 hours (in a preferred embodiment, at least about 15 minutes) at a temperature ranging from about 4.degree. C. to about 37.degree. C.). In a most preferred embodiment, hybridization under high stringent conditions is carried out in 5.times.SSC, 50% (lionized Formarnide, 0.1% SDS at 42.degree. C. overnight.

[0145] Hybridization specificity can be evaluated by comparing the hybridization of specificity-control nucleic acid probes to specificity-control target polynucleotides that are added to a sample in a known amount. The specificity-control target polynucleotides may have one or more sequence mismatches compared with the corresponding nucleic acid probes. In this manner, whether only complementary target polynucleotides are hybridizing to the nucleic acid probes or whether mismatched hybrid duplexes are forming is determined.

[0146] Hybridization reactions can be performed in absolute or differential hybridization formats. In the absolute hybridization format, target polynucleotides from one sample are hybridized to the probes in an array (e.g., in a microarray format) and signals detected after hybridization complex formation correlate to target polynucleotide levels in a sample. In the differential hybridization format, the differential expression of a set of genes in two biological samples is analyzed. For differential hybridization, target polynucleotides from both biological samples are prepared and labeled with different labeling moieties. A mixture of the two labeled target polynucleotides is added to an array (e.g., a microarray). The array is then examined under conditions in which the emissions from the two different labels are individually detectable. Probes in the array that are hybridized to substantially equal numbers of target polynucleotides derived from both biological samples give a distinct combined fluorescence (Shalon et al. PCT publication WO95/35505). In a preferred embodiment, the labels are fluorescent labels with distinguishable emission spectra, such as a lissamine conjugated nucleotide analog and a fluorescein conjugated nucleotide-analog. In another embodiment Cy3/Cy5 fluorophores (Amersham Pharmacia Biotech) are employed.

[0147] After hybridization, the array (e.g., microarray) is washed to remove nonhybridized polynucleotides and complex formation between the hybridizable array elements and the target polynucleotides is detected. Methods for detecting complex formation are well known to those skilled in the art. In a preferred embodiment, the target polynucleotides are labeled with a fluorescent label and levels and patterns of fluorescence indicative of complex formation are measured. In one embodiment, the measurement is accomplished by fluorescence microscopy, preferably confocal fluorescence microscopy. An argon ion laser excites the fluorescent label, emissions are directed to a photomultiplier and the amount of emitted light detected and quantitated. The detected signal should be proportional to the amount of probe/target polynucleotide complex at each position of the microarray. The fluorescence microscope can be associated with a computer-driven scanner device to generate a quantitative two-dimensional image of hybridization intensity. The scanned image is examined to determine the abundance/expression level of each hybridized target polynucleotide. In another embodiment, the measurement of levels and patterns of fluorescence is accomplished with a fluorescent imaging device, such as a microarray scanner (e.g., Axon scanner with GenePix Pro software). As with the previous measurement method, the measurements can be used to determine the abundance/expression level of each hybridized target polynucleotide.

[0148] In a differential hybridization experiment, target polynucleotides from two or more different biological samples are labeled with two or more different fluorescent labels with different emission wavelengths. Fluorescent signals are detected separately with different photomultipliers set to detect specific wavelengths. The relative abundances/expression levels of the target polynucleotides in two or more samples is obtained.

[0149] Typically, array fluorescence intensities can be normalized to take into account variations in hybridization intensities when more than one array is used under similar test conditions. In a preferred embodiment, individual probe/target complex hybridization intensities are normalized using the intensities derived from internal normalization controls contained on each microarray.

[0150] Other methods for quantitating the amount of an expressed nucleic acid (e.g., an expressed mRNA) corresponding to a molecular marker of interest of the invention will be evident to the skilled worker. For example, any of a variety of quantitative amplification procedures, such as quantitative PCR, can be carried out. Methods for selecting suitable amplification primers, based on the sequences disclosed herein, for optimizing amplification conditions, and for detecting and quantitating the amplified product, are conventional. Some such procedures are discussed herein with reference to amplifying nucleic acid samples in preparation for hybridization assays.

[0151] Other aspects of the invention relate to methods for determining the responsiveness of a rectal adenocarcinoma to radiochemotherapy, comprising detecting the presence of and/or quantitating the amount of, one or more protein (polypeptide) products whose expression is correlated with the responsiveness. The terms "protein" and "polypeptide" are used interchangeably herein.

[0152] Polypeptides whose expression is measured include those comprising SEQ ID NOs: 59-112.

[0153] The presence or quantity of the protein product in a body fluid, a stool sample, or, preferably, in a tissue or cell sample from the subject, is determined, and compared to a baseline value.

[0154] Methods of preparing samples (e.g., from patients) for polypeptide analysis are conventional and well known in the art, and a variety of methods known to skilled workers can be used to determine the amount of these proteins. For example, enzymatic activities of the proteins can be measured, using conventional procedures. Alternatively, the proteins can be detected by immunological methods such as, e.g., immunoassays (EIA), radioimmunoassay (RIA), immunofluorescence microscopy, or immunahistochemistry, all of which assay methods are fully conventional. See, e.g., U.S. Pat. No. 6,602,661.

[0155] The invention includes antibodies which are specific for polypeptides comprising SEQ ID NOs: 59-112, or for active variants or fragments of these polypeptides. An "active" variant or fragment of a polypeptide of the invention is one which is able to bind to, or to elicit, an antibody that is specific for a polypeptide corresponding to one of genes 1-54. For example, polypeptides comprising small substitutions, additions, deletions, etc., are tolerated provided they retain the ability to elicit a desired antibody, as are suitable antigenic fragments of the polypeptides. Antigens that exhibit at least about 90% (e.g., at least about 95%, or at least about 98%)sequence identity to a polypeptide comprising one of SEQ ID NOs; 59-112, or to a fragment thereof, are also tolerated. Methods for determining ifs polypeptide exhibits a particular percent identity to a polypeptide comprising, e.g., one of SEQ ID NOs; 59-112 are conventional; algorithms such as those discussed elsewhere herein in regard to nucleic acids can be used.

[0156] In a preferred embodiment, antibodies of the invention are immobilized on a surface (e.g., are reactive elements on an array, such as a microarray, or are on another surface, such as used for surface plasmon resonance (SPR)-based technology [e.g., Biacore]), and polypeptides in the sample are detected by virtue of their ability to bind specifically to the antibodies. Methods of preparing the surfaces and performing the analyses are conventional.

[0157] Any of a variety of antibodies can be used in methods of the invention. Such antibodies include, e.g., polyclonal, monoclonal (mAbs), recombinant, humanized or partially humanized, single chain, Fab, and fragments thereof. The antibodies can be of any isotype, e.g., IgM, various IgG isotypes such as IgG.sub.1' IgG.sub.2a etc., and they can be from any animal species that produces antibodies, including goat, rabbit, mouse, chicken or the like. An antibody "specific for" a polypeptide means that the antibody recognizes a defined sequence of amino acids, or epitope, either present in the full length polypeptide or in a peptide fragment thereof.

[0158] Antibodies can be prepared according to conventional method, which are well known, e.g. Green at al., Production of Polyclonal Antisera, in Immunochemical Protocols (Manson, ed.), (Humana Press 1992); Coligan at al., in Current Protocols in Immunology, Sec. 2.4.1 (1992); Kohler & Milstein (1975), Nature 256 495; Coligan at al., sections 2.5.1-2.6.7; and Harlow at al., Antibodies: A Laboratory Manual, page 726 (Cold Spring Harbor Laboratory Pub. 1988), Methods of preparing humanized or partially humanized antibodies, and antibody fragments, and methods of purifying antibodies, are conventional.

[0159] The molecular profiling information described herein can be harnessed for the purpose of identifying agents (e.g., drugs) that can enhance (increase, facilitate, potentiate, etc.) the response of a rectal adenocarcinoma to radiochemotherapy. Such agents are particularly useful when administered, as therapeutic agents, in conjunction with radiochemotherapy, in order to enhance the effect of the radiochemotherapy. For example, the agents can be administered to a subject before, during or after radiochemotherapy is carried out. Agents are selected which enhance expression or activity of one or more genes whose up-regulation is correlated with the responsiveness, and/or which decrease expression and/or activity of one or more genes whose down-regulation is correlated with the responsiveness.

[0160] In assays to identify such agents, putative agents are introduced into cells, and either polynucleotide expression or activity levels, or polypeptide expression or activity levels, are measured. The expression and/or activity levels of polynucleotides or polypeptides corresponding to marker genes of the invention are determined. Preferably, the methods are carried out in vitro, with cultured cells or with tumor tissue, and employ high throughput procedures. Candidate agents selected in this manner can then be tested further in vivo.

[0161] In one embodiment, rectal adenocarcinoma cell lines are prepared from tumors that are either responsive or non-responsive to radiochemotherapy, using standard methods, and are profiled using the present methods. Preferred cell lines are those that maintain the expression profile of the primary tumor from which they were derived. One or several such cell lines may be used as a "general" panel; alternatively or additionally, cell lines from individual subjects may be prepared and used. In other embodiments, previously established rectal adenocarcinoma cell lines are used or non-tumor rectal cells, or cells from other normal tissues, are used. A skilled worker can readily select a suitable cell line to use in the method.

[0162] The molecular alterations in cell line cells contacted with a putative modulatory agent can be measured at the mRNA level (gene expression) applying conventional methods, such as those disclosed herein. Alternatively, one can assay the protein product(s) or activities of the selected gene(s), using conventional procedures. For example, in the ease of secreted or cell-surface proteins, expression can be assessed using immunoassay or other immunological methods including enzyme immunoassays (EIA), radioimmunoassay (RIA), immunofluorescence microscopy or flow cytometry. EIAs are described in greater detail in several references (Butler, J E, In: Structure of Antigens, Vol. 1 (Van Regenmortel, M., CRC Press, Boca Raton 1992, pp. 209-259; Butler, J E, "ELISA," In: van Oss, C. J. et al. (eds), Immunochemistry, Marcel Dekker, Inc., New York, 1994, pp. 759-803; Butler, J E (ed,), Immunochemistry of Solid-Phase Immunoassay, CRC Press, Boca Raton, 1991). RIAs are discussed in Kirkham and Hunter (eds.), Radioimmune Assay Methods, E. & S. Livingstone, Edinburgh, 1970. Preferably, polypeptide samples are contacted with antibody compositions of the invention that are in the form of an array, such as a microarray, and are analyzed as described elsewhere herein.

[0163] Without wishing to be bound by any particular mechanism, it is suggested that, among the types of agents that can be tested and identified as therapeutic agents are, e.g., agents that (1) act on a cellular pathway that inhibits or stimulates expression of a gene of interest, (2) act directly on the protein product, or (3) bypass the step in a cellular pathway mediated by the product of this gene.

[0164] A variety of types of agents can be tested and identified as the desired agents.

[0165] For example, one can utilize known properties of a target protein to devise agents to stimulate or inhibit its production or activity, as desired. That is, one can devise a means to inhibit the action of or bind, block, remove or otherwise diminish the presence, activity and/or availability of, a protein whose down-regulation is associated with responsiveness to radiochemotherapy; or one can devise a means to stimulate the action of, or to potentiate or enhance the activity of or availability of; a protein whose up-regulation is associated with such responsiveness. For example, in the case of a cellular receptor, one could expose the receptor to an antagonist, a soluble form of the receptor or a "decoy" ligand binding site of a receptor (to compete for ligand) (Gershoni J M et al., (1988) Proc Natl Aced Sci USA 85, 4087-9; U.S. Pat. No. 5,770,572) to inhibit it.

[0166] Antibodies may be administered to a cell to bind and inactivate (or compete with), or to enhance the activity of, secreted protein products or expressed cell-surface products of genes of interest.

[0167] Another approach is to employ antisense oligonucleotides or nucleic acid constructs that inhibit expression of a gene whose down-regulation is desired, in a highly specific manner. Methods to select, test and optimize putative antisense sequences are routine. In one embodiment, nucleic acid constructs are used to express an antisense molecule of interest. Methods to operatively link appropriate antisense sequences to an appropriate regulatory element, e.g., a promoter, such as a strong promoter, an inducible strong promoter, or the like. Inducible promoters include, e.g., an estrogen inducible system (Braselmann et al. (1993) Proc Natl Acid Sci USA 90, 1657-1661). Also known are repressible systems driven by the conventional antibiotic, tetracycline (Gossen et al,, (1992) Proc. Natl. Acad. Sci. USA 89, 5547-5551).

[0168] In another embodiment of inhibition by antisense, antisense oligonucleotides are administered to a cell. The oligonucleotides can be DNA or RNA or chimeric mixtures or derivatives or modified versions thereof, single-stranded or double-stranded. The oligonucleotides can be modified at the base moiety, sugar moiety, or phosphate backbone (as discussed above). The oligonucleotide may include other appending groups such as peptides, or agents facilitating transport across the cell membrane (see, e.g. Letsinger at al. (1989) Proc. Natl. Acad. Sci. USA 84, 684-652; PCT Publication WO 88/09810 (1988)), hybridization-triggered cleavage agents (e.g. Krol et al, (1988), Bio Techniques 6, 958-976) or intercalating agents (e.g., Zon (1988), Pharm. Res 5, 539-549),

[0169] Multiple antisense constructs or oligonucleotides specific for different genes can be employed together. The sequences of the downregulated genes described herein can be used to design the antisense molecules (Hambor et al., (1988) J. Exp. Med. 168, 1237-1245; Holt et al., (1986) Proc. Nat'l. Acad. Sci. 83, 4794-4798; Izant et al., (1984) Cell 36, 1007-1015); Izant et al,, (1985) Science 222, 345-352; De Benedetti et al., (1987) Proc. Natl. Acad. Sci. USA, 84, 658-662). The antisense sequences may range from about 6 to about 50 nucleotides, and may be as large as 100 or 200 nucleotides, or larger. They may correspond to full-length coding sequences and/or may be genomic sequences that comprise non-coding sequences.

[0170] Another approach is to use ribozymes that can specifically cleave nucleic acids encoding the overexpressed genes of the invention. Such methods are routine in the art and methods of making and using any of a variety of appropriate ribozymes are well known to the skilled worker. For reviews on ribozymes see e.g., Ohkawa et al. (1995) J. Biochem. 118, 251-258; Sigurdsson et al. (1995) Trends Biotechnol. 13, 286-289; Rossi, J. J. (1995) Trends Biotechnol. 13, 301-306; Kiehntopf et al. (1995) J. Mol. Med. 73, 65-71). A ribozyme having specificity for an mRNA of interest can be designed based upon the nucleotide sequence of, e.g., the corresponding cDNA. For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the base sequence of the active site is complementary to the base sequence to be cleaved in an mRNA corresponding to one of the overexpressed genes of the invention. See for example U.S. Pat. Nos. 4,987,071 and 5,116,742, both by Cech et al. Alternatively, the sequence of an overexpressed gene of the invention can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See for example Bartel et al. (1993) Science 261, 1411-1418.

[0171] Another approach involves double stranded RNAs called small interfering RNAs. An siRNA is a double-stranded RNA molecule comprising self-complementary sense and antisense regions, wherein the antisense region comprises nucleotide sequence that is complementary to nucleotide sequence in a target nucleic acid molecule or a portion thereof, and the sense region has a nucleotide sequence corresponding to the target nucleic acid sequence or a portion thereof. The siRNA can be assembled from two separate oligonucleotides, where one strand is the sense strand and the other is the antisense strand, wherein the antisense and sense strands are self-complementary. The siRNA can be assembled from a single oligonucleotide, where the self-complementary sense and antisense regions of the siRNA are linked by means of a nucleic acid based or non-nucleic acid-based linker(s). The siRNA can be a polynucleotide with a hairpin secondary structure, having self-complementary sense and antisense regions. The siRNA can be a circular single-stranded polynucleotide having two or more loop structures and a stem comprising self-complementary sense and antisense regions, wherein the circular polynucleotide can be processed either in vivo or in vitro to generate an active siNA molecule capable of mediating RNAi. In certain embodiments, the siNA molecule of the invention comprises separate sense and antisense sequences or regions, wherein the sense and antisense regions are covalently linked by nucleotide or non-nucleotide linkers molecules as is known in the art, or are alternately non-covalently linked by ionic interactions, hydrogen bonding, van der waals interactions, hydrophobic interactions, and/or stacking interactions.

[0172] RNAi molecules can be used to inhibit gene expression, using conventional procedures. Typical method to design, make and use interfering RNA molecules are described, e.g., in U.S. Pat. No. 6,506,559, Lau et al. (2003) Scientific American, pp, 34-41; McManus et al. (2002) Nature Reviews Genetics 3, 737-747; Dylochoorn at al. (2003) Nature Reviews Molecular Cell Biology 4, 457-467; Allshire (2002) Science 297, 1818-1819; Volpe at al. (2002) Science 297, 1833-1837; Jenuwein (2002) Science 297, 2215-2218; Hall at al, (2002) Science 297 2232-2237; Hutvagner at al. (2002) Science 227, 2056-60; McManus at al. (2002) RNA 8, 842-850; Reinhart et al. (2002) Gene & Dev. 16, 1616-1626; Reinhart at al. (2002) Science 297, 1831; Fire et al. (1998) Nature 391, 806-811, Moss (2001) Curr Biol 11, R772-5, Brummelkamp at al. (2002) Science 296, 550-3; Bass (2001) Nature 411 428-429; and Elbashir at al. (2001) Nature 411, 494-498; U.S. Pat. No. 6,506,559; US patent application 20030206887; and PCT applications WO99/07409, WO99/32619, WO 00/01846, WO 00/44914, WO00/44895, WO01/29058, WO01/36646, WO01/75164, WO01/92513, WO 01/29058, WO01/89304, WO01/90401, WO02/16620, and WO02/29858. For guidance on methods to design interfering RNA molecules, see, e.g., Vickers at al. (2003), J Biol Chem 278, 7108-7118 and Yang et al. (2003) Proc Natl Acad Sci USA 99, 9942-9947, For methods to make siRNAs, see e.g. Tuschl at al. (1999) Genes & Dev. 13, 3191-3197; Kawasaki at al. (2003) Nucleic Acids Res 31, 700-707; Miyagishi et al. (2003) Nature Biotechnol 20, 497-500; Lee at al. (2002) Nature Biotechnol 20, 500-505, Brummelkamp et al. (2002) Science 296, 550-553; McManus et al. (2002) RNA 8, 842-850; Paddison et al. (2002a) Gene Dev 16, 948-958; Paddison et al. (2002b) Proc Nat'l Acad Sci USA 99, 1443-1448); Paul at al. (2002) Nature Biotechnol 20, 505-508; Sui et al. (2002) Proc Natl Acad Sci USA 99, 5515-5520; and Yu et al. (2002) Proc Natl Acad Sci USA 99, 6047-6052. For methods to use siRNAs to inhibit expression, see e,g. Hannon (2002) Nature 418, 244-251; Bernstein et al., (2002) RNA 7, 1509-1521; Hutvagner et al., Curr. Opin. Genetics & Development 12, 225-232; Brummelkamp (2002) Science 296, 550-553; Lee et al. (2002) Nature Biotechnol 20, 500-505; Miyagishi et al. (2002) Nature Biotechnol. 20, 497-500; Paddison at al. (2002) Genes & Dev 16, 948-958; Paul et al. (2002) Nature Biotechnol. 20, 505-508; Sui at al. (2002) Proc. Natl. Acad. Sci. USA 99, 5515-5520; and Yu et al. (2002) Proc. Natl. Acad. Sci. USA 99, 6047-6052.

[0173] Another approach is to use small molecules (sometimes referred to herein as "compounds"). They may be isolated from natural sources or developed synthetically, e.g., by combinatorial chemistry. In general, such molecules are identified from large libraries of natural products or synthetic (or semi-synthetic) extracts or chemical libraries according to methods known in the art. Those skilled in the field of drug discovery and development will understand that the precise source of test extracts or compounds is not critical to the methods of the invention. Accordingly, virtually any number of chemical extracts or compounds can be used in the methods described herein. Examples of such extracts or compounds include, but are not limited to, plant-, fungal-, prokaryotic- or animal-based extracts, fermentation broths, and synthetic compounds, as well as modification of existing compounds. Numerous methods are also available for generating random or directed synthesis (e.g., semi-synthesis or total synthesis) of any number of chemical compounds, including, but not limited to, saccharide-, lipid-, peptide-, polypeptide- and nucleic acid-based compounds. Synthetic compound libraries are commercially available, e.g., from Brandon Associates (Merrimack, N.H.) and Aldrich Chemical (Milwaukee, Wis.).

[0174] Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant, and animal extracts are commercially available from a number of sources, e.g., Biotics (Sussex, UK), Xenova (Slough, UK), Harbor Branch Oceangraphics Institute (Ft. Pierce, Fla.), and PharmaMar, U.S.A. (Cambridge, Mass.), In addition, natural and synthetically produced libraries are generated, if desired, according to methods known in the art, e.g., by standard extraction and fractionation methods. Furthermore, if desired, any library or compound is readily modified using standard chemical, physical, or biochemical methods.

[0175] Once a molecule has been identified in vitro as a candidate agent that increases the responsiveness of a rectal adenocarcinoma to radiochemotherapy, one can further determine in vivo if the candidate does, in fact, increase the responsiveness in a subject. Furthermore, if a candidate agent is shown to inhibit or stimulate expression or activity o f several genes whose expression is correlated with the responsiveness, one can inhibit or stimulate the expression of each of the genes individually, in viva, in order ID determine those genes whose expression is correlated to the responsiveness.

[0176] The candidate agent(s) can be introduced into any suitable animal model for rectal carcinoma. Eventually, agents that have been shown to be safe and effective in animal models can be tested and used in human patients.

[0177] Methods for introducing agents into cells or animals are conventional. For example, methods of gene transfer can be used, wherein antisense molecules, ribozymes, or siRNAs are introduced into a rectal adenocarcinoma cell, tissue or organ of interest, or nucleic acids that encode proteins which modulate (up-regulate or down-regulate) the production or activity of one or more of the genes of the invention are so introduced. Methods of gene transfer are conventional, and include virus-mediated gene transfer, for example, with retroviruses (Nabel et al. (1989) Science 244, 1342), lentiviruses, and recombinant adenovirus vectors (Horowitz, M. S., In Virology, Fields, B N et al, eds, Raven Press, New York, 1990, p. 1679, or current edition; Berkner (1988) Biotechniques 6, 616-29, Strauss, S E, In; The Adenoviruses, Ginsberg, H S, ed., Plenum Press, New York, 1984, or current edition). Adeno-associated virus (AAV) can also be used (Samulski et al, (1991)EMBO J. 10, 3941 (1991); Lebkowski et al. (1988) Mol. Cell. Biol. 8, 3988-3996; Kahn et al (1990), Proc. Natl. Acad. Sci. USA 87, 2211-2215; Hermonat et al, (1984), J. Viral. 51, 329-339). Improved efficiency is attained by the use of promoter enhancer elements in the DNA constructs (Philip et al. (1993), J. Biol. Chem. 268, 16087-16090).

[0178] In addition to virus-mediated gene transfer, physical means well-known in the art can be used for direct gene transfer, including administration of plasmid DNA (Wolff at al, 1990, supra) and particle-bombardment mediated gene transfer, originally described in the transformation of plant tissue (Klein et al (1987), Nature 327, 70 (1987); Christou, at al. (1990), Trends Biotechnol. 6, 145) but also applicable to mammalian tissues in vivo, ex vivo or in vitro (Yang et al, (1990), Proc. Natl. Acad. Sci. USA 87, 9568 (1990); Williams at al. (1991), Proc. Natl. Acad. Sci. USA 88, 2726; Zelenin et al. (1991), FEBS Lett. 280, 94; Zelenin at al. (1989), FEBS Lett. 244, 65; Johnston et al. (1991), In Vitro Cell. Dev. Biol, 27, 11). Furthermore, electroporation or calcium phosphate transfection, both well-known means to transfer genes into cell in vitro, can also be used to transfer DNA molecules according to the present invention to tissues in vivo (Pear et al. (1993) Proc. Natl. Acad. Sci. USA 90, 8392; Titomirov at al. (1991), Biochim. Biophys. Acta 1088, 131).

[0179] Gene transfer can also be achieved using "carrier mediated gene transfer" (Wu et al. (1989), J. Biol. Chem. 264, 16985; Wu at al. (1988), J. Biol., Chem. 263, 14621; Soriano et al. (1983), Proc. Nail. Acad. Set. USA 80, 7128; Wang at al. (1982), Proc. Natl. Acad. Sci. USA 84, 7851; Wilson at al. (1992), J. Biol. Chem. 267, 963). Preferred carriers are targeted liposomes (Nicolau at al. (1983), Proc. Natl. Acad. Sci, USA 80, 1068 (1983); Soriano at al., supra) such as immunoliposomes, which can incorporate acylated monoclonal antibodies into the lipid bilayer (Wang at al., supra), or polycations such as asialoglycoprotein/polylysine (Wu et al., 1989, supra). Liposomes have been used to encapsulate and deliver a variety of materials to cells, including nucleic acids and viral particles (Faller et al (1984), J. Virol. 49, 269-272).

[0180] Preformed liposomes that contain synthetic cationic: lipids form stable complexes with polyanionic DNA (Feigner at al, (1987), Proc. Nail. Acad. Sci. USA 84, 7413-7417). Cationic liposomes, liposomes comprising some cationic lipid, that contained a membrane fusion-promoting lipid dioctadecyldimethyl-ammonium-bromide (DDAB) have efficiently transferred heterologous genes into eukaryotic cells (Rose et al. (1991), Biotechniques 10, 520-525). Cationic liposomes can mediate high level cellular expression of transgenes, or mRNA, by delivering them into a variety of cultured cell lines (Malone et al. (1989), Proc. Natl. Acad. Sci. USA 86 6077-6081).

[0181] Another embodiment of the invention is a method for identifying a gene whose inhibition (e.g., inhibition of nucleic acid expression or activity, or inhibition of polypeptide synthesis or activity) enhances the response of a rectal tumor to radiochemotherapy. For example, one can test one or more of the genes of the invention whose over-expression is correlated with responsiveness of a rectal adenocarcinoma to radiochemotherapy (e.g., genes 1-41). The method can be carried out in vitro, but is preferably carried out in vivo, in a suitable animal model. In one embodiment, the method comprises:

[0182] a. inhibiting (completely or partially, using, agents such as those discussed elsewhere herein) in a rectal adenocarcinoma the expression and/or activity of a polynucleotide corresponding to one of genes 1-41 (e.g., polynucleotide that hybridizes specifically to a nucleic acid comprising one of SEQ ID NOs: 1-41 or 113-119, and/or to a fragment that comprises at least about 15 contiguous nucleotides of one of those sequences; or to a complement of one of those fragments); or inhibiting the synthesis and/or activity of a polypeptide corresponding to one of genes 1-41 (e.g., a polypeptide that binds specifically to an antibody of the invention, such as an antibody specific for one of polypeptides comprising SEQ ID NOs: 59-101, and/or for an antigenic fragment of one of those polypeptides), and

[0183] b. determining if the rectal adenocarcinoma exhibits an increased response to radiochemotherapy, compared to the response in the absence of the inhibition.

[0184] Another embodiment of the invention is a method for identifying a gene whose stimulation (e.g., stimulation of nucleic acid expression or activity, or stimulation of polypeptide synthesis or activity) enhances the response of a rectal tumor to radiochemotherapy, comprising:

[0185] a. stimulating (completely or partially, using agents such as those discussed elsewhere herein) in a rectal adenocarcinoma the expression and/or activity of a polynucleotide corresponding to one of genes 42-54 (e.g., a polynucleotide that hybridizes specifically to a nucleic acid comprising one of SEQ NOs: 46-58 or 120-123, and/or to a fragment that comprises at least about 15 contiguous nucleotides of one of those sequences, or to a complement of one of those nucleic acids or fragments); or inhibiting the synthesis and/or activity of a polypeptide corresponding to one of genes 42-54 (e.g., a polypeptide that binds specifically to an antibody of the invention, such as an antibody specific for a polypeptide comprising one of SEQ ID NOs: 102-112, and/or for an antigenic fragment of one of those polypeptides), and

[0186] b. determining if the rectal adenocarcinoma exhibits an increased response to radiochemotherapy, compared to the response in the absence of the stimulation.

[0187] Other aspects of the invention are kits suitable for performing any of the methods of the invention.

[0188] One embodiment of the invention is a kit for detecting the presence and/or amount of a polynucleotide in a sample from a rectal adenocarcinoma, which may indicate that the rectal adenocarcinoma is responsive to radiochemotherapy, comprising a composition of nucleic acids of the invention (e.g., in the form of an array) and, optionally, one or more reagents that facilitate hybridization of the nucleic acids in the composition to a test polynucleotide of interest, and/or that facilitate detection of the hybridized polynucleotide(s), e.,g., that facilitate detection of fluorescence. The kit may comprise a composition of nucleic acids of the invention (e.g., in the form of an array), means for carrying out hybridization of the nucleic acids in the array to a test polynucleotide(s) of interest, and means for reading hybridization results. Hybridization results may be units of fluorescence.

[0189] Another embodiment is a kit for detecting the presence and/or amount of a polypeptide in a sample from a rectal adenocarcinoma, which may indicate that the rectal adenocarcinoma is responsive to radiochemotherapy, comprising a composition of antibodies of the invention (e.g., in the form of an array) and, optionally, one or more reagents that facilitate binding of the antibodies in the composition with a test protein(s) of interest, or that facilitate detection of bound antibody. The kit may comprise a composition of antibodies of the invention (e.g., in the form of an array or a Biacore chip), means for carrying out binding of the antibodies in the array to a test polypeptide(s) of interest, and means for reading the binding results.

[0190] Kits of the invention may comprise instructions for performing a method, such as a diagnostic method. Other optional elements of a kit of the invention include suitable buffers, media components, or the like; a computer or computer-readable medium for storing and/or evaluating the assay results; containers; or packaging materials. Reagents for performing suitable controls may also be included. The reagents of the kit may be in containers in which the reagents are stable, e.g., in lyophilized form or stabilized liquids. The reagents may also be in single use form, e.g., in single reaction form for diagnostic use.

[0191] The present invention also relates to combinations of the invention in which the nucleic acid or protein sequences of the invention are represented, not by physical molecules, but by computer-implemented databases. For example, the present invention relates to electronic forms of polynucleotides, polypeptides, antibodies, etc., of the present invention, including a computer-readable medium (e.g., magnetic, optical, etc., stored in any suitable format, such as flat files or hierarchical files) which comprise such sequences, or fragments thereof, e-commerce-related means, etc. An investigator may, e.g., compare an expression profile exhibited by a rectal adenocarcinoma sample of interest to an electronic form of one of the expression profiles of the invention, and may thereby determine its responsiveness to radiochemotherapy.

[0192] Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention, unless specified. In the foregoing and in the following examples, all temperatures are set forth uncorrected in degrees Celsius; and, unless otherwise indicated, all parts and percentages are by weight.

EXAMPLES

Example I

Patients and Methods

A. Selection of Patients and Response Classification

[0193] All patients are participants in a multicenter, randomized prospective phase III clinical trial (CAO/ARD/AIO-94, German Rectal Cancer Trial) aimed at determining the relative benefits of preoperative (neoadjuvant) versus postoperative (adjuvant) radiochemotherapy (Sauer at al. (2001) Strahleuther Onkol 177, 173-81). For the study here, we collected biopsies from 23 patients between December 2001 to October 2002 who were assigned to the neoadjuvant treatment arm adhering to the guidelines set by the local ethical review board. Pre-therapeutic staging was performed including complete medical history and physical evaluation, digital rectal examination, endorectal ultrasound, rigid rectoscopy with two tumor biopsies, colonoscopy, abdominal ultrasound, abdominal and pelvic computed tomography and chest X-ray. Endoscopic ultrasound was performed by two experienced surgeons and was based on the degree of tumor infiltration through the rectal wall (T-level) according to standard criteria (Liersch at al. (2003) Chirurg 74, 224-34; Adams et a7. (1999) Dis Colon Rectum 42, 159-66; Glaser at al. (1990) Br J Surg 77, 883-7; Hunerbein at al. (2001) Eur J Ultrasound 13, 17-23). Only patients with uT-level 3 (n=22) and uT-level 4 (n=1) carcinomas located within 16 cm from the anocutaneous verge were included. The majority of the patients were diagnosed with uUICC III (n=16) carcinomas, and only seven patients were diagnosed as uUICC II. Two pre-therapeutical biopsies were taken from representative, adjacent areas of the tumors one of which was examined by one pathologist. All rectal cancers were histologically diagnosed as adenocarcinomas. The second biopsy was used for RNA extraction. All 23 patients randomly assigned to the neoadjuvant arm received a total dose of 50.4 Gy of radiation accompanied by 5-fluorouracil (5-FU 1000 mg per m.sup.2, days 1-5 and days 28-33) intravenous application. Details of the preoperative treatment modalities were described previously (Sauer et al. (2001) Strahlenther Onkol 177, 173-81). Standardized surgery was performed including total mesorectal excision (TME, (Heald et al. (1986) Lancet 1, 1479-82)) alter an interval of approximately five weeks after radiochemotherapy. The histological workup of surgical specimens was performed according to UICC standards (Sobin L H, Wittekind C. UICC: TNM classification of malignant tumors. 5 ed. New York: John Wiley & Sons, 1997). Tumor response was assessed based on T-level down-sizing (as performed by rectal ultrasound before radiochemotherapy and histomorphologically after surgery). Down-sizing was defined as the reduction of tumor infiltration for at least one T-level. The experimental design is summarized in FIG. 1. We have chosen the T-level classification as the international standard for rectal cancer staging. The clinical data and details of the response classification are summarized in Table 1. Additionally, three matched pairs of preoperative biopsies and resected tumor specimens from patients of the adjuvant treatment arm were analyzed to establish the degree of similarity of the bioptic material and resected specimen.

TABLE-US-00001 TABLE 1 Tumor ypN ypN Samples uT ypT uUICC ypUICC uN ypN total infiltrated M ypGrading R P1 3 0 II 0 0 0 18 0 0 x 0 P2 3 0 III 0 1 0 27 0 0 x 0 P3 3 0 II 0 0 0 16 0 0 x 0 P4 3 2 III I 1 0 22 0 0 2 0 P5 3 1 II I 0 0 20 0 0 2 0 P6 3 2 III I 1 0 24 0 0 2 0 P7 3 1 II II 0 0 18 0 0 2 0 P8 4 3c III III 0 1 19 3 0 3 0 P9 3 2 II I 0 0 16 0 0 3 0 P10 3 3b III III 1 1 30 1 0 2 0 P11 3 3b III II 1 0 15 0 0 2 0 P12 3 3b II III 0 0 8 1 0 3 0 P13 3 3b III III 1 1 27 1 0 2 0 P14 3 4a III III 1 1 19 1 0 2 0 P15 3 3b III II 1 0 28 0 0 2 0 P16 3 3a III II 1 0 21 0 0 2 0 P17 3 3b III III 1 1 19 2 0 3 0 P18 3 4a III III 1 1 21 2 0 2 0 P19 3 3c III II 1 0 24 0 0 3 0 P20 3 3c II II 0 0 16 0 0 2 0 P21 3 3c III II 1 0 17 0 0 2 0 P22 3 3a III II 1 0 14 0 0 2 0 P23 3 4a III III 1 1 22 1 0 2 0

Therapy response and clinical data of 23 patients included in this study. uT, T-level determined by rectal ultrasound; ypT, T-level by histopathological assessment; uUICC, UICC stage by ultrasowad; ypUICC, UICC stage by histopathological assessment; uN, lymph node status by ultrasound; ypN, lymph node status by histopathological assessment; ypN total, complete number of analyzed lymph nodes; ypN infiltrated, number of affected lymph nodes; M, distant metastasis; ypGrading, tumor grading by histopathological assessment; R, resectability (O refers to histologically tumor free surgical margins). u: before any treatment, yp: histopathological assessment after neodadjuvant treatment,

B. RNA Isolation and Expression Profiling

[0194] Following rectal ultrasound, tumor biopsies were ascertained and stored for later isolation of RNA (Ambion, Austin, Tex.). Tumor material was in the range of 5 mg to 80 mg. RNA extraction was performed using TRIZOL (Invitrogen, Carlsbad, Calif.) following standard procedures. High-quality RNA could be successfully extracted from all samples. In order to generate enough RNA for repeat hybridizations, inRNA was amplified using the RiboArrip RNA amplification kit (Arcturus, Mountain View, Calif.), which resulted in antisense mRNA amounts that averaged 40 .mu.g. cRNA was reverse transcribed into cDNA incorporating aminoallyl-dUTP, Labeled cDNA was purified using Qiagen columns (QIAquick, PCR purification kit, Qiagen, Los Angeles, Calif.), followed by chemical coupling of Cy3 (Amersham, Piscataway, N.J.). Control cRNA was generated by amplification of a universal human reference mRNA pool (Stratagene, La Jolla, Calif.; catalogue number 740000) and labeled as above using Cy5 (Amersham). RNA quantification and labeling efficiency was determined using the Nanodrop quantification device (Nanodrop, Rockland, Del.). Expression profiling was carried out on the NCI-cDNA arrays (9984 genes) as follows: 3.0 .mu.g of Cy3 labeled test cDNA and 3.0 ng of Cy5 labeled control cDNA were hybridized at 42.degree. C. overnight in specifically designed hybridization cassettes (TeleChem International, Inc., Sunnyvale, Calif.). After hybridization, slides were washed and scanned on an Axon scanner using GenePixPro (3.0) software (Axon Instruments, Inc., Union City, Calif.). Background subtraction and normalization was performed when submitting the data to the CIT/NIH-microarray database, mAdb (web site nciarray.nih.gov). Spot quality was assessed according to criteria in GenePixPro (3.0) software. Spots with a small size or low intensity in both the red and green channels were eliminated, as were genes with more than 50% of missing data. This a priori filtering to remove genes with unreliable signals resulted in a final tally of 9059 genes. For each patient sample two independent hybridizations were performed. Correlation coefficients of the technical repeat hybridizations were greater than 0.95, with one exception (P1, correlation coefficient of 0.87).

C. Statistical Analysis

[0195] All statistical analyses were done on the BRBArrayTools package for micro-array analysis developed at the Biometric Research Branch of the National Cancer Institute (Simon R, Peng A. BRBArrayTools, 2003). BRBArrayTools can be obtained from the web site linus.nci.nih.gov/BRB.about.ArrayTools.html. Technical replicate expression profiles of the same tumor specimen were highly consistent and were averaged for analysis. A class comparison analysis was applied to determine which genes were differentially expressed between the two classes. For this we used a two-sample T-test with a randomized variance model (Wright G, Simon R. A random variance model for differential gene detection in small sample microarray experiments, 2003. Tech. Rep. 013, Biometric Research Branch, National Cancer Institute, at the web site linus.ncianh.gov/.about.bib/TechReport.htm. The randomized variance model assumes that the variance of the expression of each gene is randomly drawn from an inverse-gamma distribution. For a small number of samples, this gives better results than assigning equal variance to all genes or attempting to estimate the variances separately for each gene.

[0196] We applied six different classification methods to predict response: Compound Covariate Predictor (Radmacher et al. (2002) J Comput Biol 9, 505-11), Diagonal Linear Discriminant Analysis (Dudoit et al. (2002) Journal of the American Statistical Association, 77-87), 1 and 3-Nearest Neighbor classifiers (Devroye, L, Gyorfi L, G. Lugosi. A probabilistic theory of pattern recognition. New York: Springer, 1996), Nearest Centroid classifier and Support Vector Machine (Vapnik V N. Statistical learning theory. New York: John Wiley & Sons, Inc 1998). The genes that are differentially expressed at a p<0.001 level were used as predictive features in the classifiers. A leave-one-out cross-validation (LOOCV) was employed to estimate the prediction accuracy for each classification method. With LOOCV one sample is left out and the remaining samples are used to build a classifier, which would then be used to classify the left out sample. Both feature selection and classifier design was repeated each time a sample was left out. The fraction of samples that are classified correctly is an estimate of the classification accuracy.

[0197] The significance of the classification results are calculated by permuting the class labels of the samples and then finding the fraction of times this re-labeling resulted in higher LOOCV classification accuracy. The method is described in detail in Radmacher et al, (Radmacher et al. (2002) J Comput Biol 9, 505-11).

Example II

Identification of Genes whose Expression is Correlated with Responsiveness to Radiochemotherapy

[0198] In order to identify molecular signatures of responsiveness of rectal carcinomas to neoadjuvant, preoperative radiochemotherapy, we analyzed gene expression profiles of 23 tumor biopsies. The flow of sample collection, clinical diagnosis, and experimental design is depicted in FIG. 1. All patients participated in a randomized clinical trial aimed at comparing the relative benefits of adjuvant versus neoadjuvant radiochemotherapy of locally advanced rectal carcinoma. Since standardization of surgical procedure and evaluation of therapy response is critical, all patient samples Were collected from a single clinic (University Medical Center Gottineen, Germany), Before biopsy sampling, initial tumor staging was performed by rectal ultrasound, a procedure that, in the experience of the inventors, shows concordance with the histomorphological classification of tumor resections in more than 85% of cases (Liersch et al. (2003) Chirurg 24, 224-34). In all instances, duplet biopsies were ascertained and submitted to either histopathological evaluation or for the purpose of expression profiling. Neoadjuvant treatment, the histological diagnosis, and surgical resection of carcinomas were standardized as part of the clinical trial.

[0199] To establish the degree of similarity of the bioptic samples and the surgically removed tumors, three matched pairs of biopsies and turners of patients from the adjuvant treatment aim were compared using gene expression profiling. Average correlation coefficients were in the range of 84%, indicating that in general the turner biopsies reflect the transcriptome of rectal carcinomas.

[0200] Gene expression profiles of the tumors from patients assigned to the neoadjuvant arm of the study were established using 10 K cDNA arrays and then evaluated by class comparison analysis. In class comparison analysis, all samples were evaluated and genes that were differentially expressed in tumors with or without response were identified.

[0201] The clinical data and response classification are listed in Table 1. Response classification was based on T-level down-sizing. Nine patients were considered responders (P1-P9) and 14 patients showed no T-level response (P10-P23). T-level down-sizing was supported by 54 genes (p<0.001), which were differentially expressed between the two response classes Classification results for T-level down-sizing were most accurate using the Compound Covariate Predictor and Diagonal Linear Discriminant analysis. Results are presented here for the Compound Covariate Predictor. Four patients were incorrectly classified, three of whom belonged to the non-response group but were classified as responders (P15, P21 and P23), while responder P1 was incorrectly placed in the non-response group. Class prediction using T-level down-sizing results in 83% correct assignment as to either responders or non-responders (p=0.03). Table 2 shows the classification accuracy obtained for the all six classifiers for the T-level down-sizing classification.

TABLE-US-00002 TABLE 2 Classification accuracy Class label 1 refers to the group of responders, class label 0 to the group of non-responders. Compound Linear Support Number of Covariate Discriminant 1-Nearest 3 Nearest Nearest Vector Tumor Class genes in Predictor Analysis Neighbor Neighbor Centroid Machine Samples label classifier Correct? Correct? Correct? Correct? Correct? Correct? P1 1 89 NO NO NO NO NO NO P2 1 48 YES NO NO NO YES NO P3 1 41 YES YES YES NO NO YES P4 1 45 YES YES NO YES YES NO P5 1 36 YES YES YES YES YES YES P6 1 39 YES YES YES YES YES YES P7 1 40 YES YES NO NO NO NO P8 1 47 YES YES NO YES YES NO P9 1 43 YES YES NO YES NO NO P10 0 41 YES YES NO YES NO YES P11 0 39 YES YES YES YES YES YES P12 0 35 YES YES YES YES YES YES P13 0 53 YES YES YES YES YES YES P14 0 38 YES YES YES YES YES YES P15 0 66 NO NO NO NO NO NO P16 0 54 YES YES YES YES YES YES P17 0 47 YES YES YES YES YES YES P18 0 40 YES YES YES YES YES YES P19 0 44 YES YES YES YES YES YES P20 0 43 YES YES YES YES NO NO P21 0 84 NO NO NO NO NO NO P22 0 46 YES YES YES YES YES YES P23 0 56 NO YES NO NO NO NO Percent 83 83 57 70 61 57 correctly classified

[0202] The sensitivity of the test measured as the percentage of responders that were predicted correctly as responders is 89% Specificity (i.e,, patients that were correctly classified as non-responders to radiochernotherapy) was 79%. The positive predictive value (percentage of patients classified as responders who were true responders) is 73% and the negative predictive value (percentage of patients classified as non-responders who were true non-responders) is 92%.

[0203] Table 3 provides the annotation of the 54 most significantly changed genes in class comparison analysis. 41 genes were down-regulated and 13 genes showed higher expression values in the group of responders. This list of genes includes calmixa, kinectin 1, copine III, villin-like, motilin, cdc42, myosin IA, cyclin T1, interleukin 12A, SMC1 (structural maintenance of chromosomes 1), platelet derived growth factor C and a number of genes that encode proteins involved in signaling, membrane transport and proteins with varying enzymatic properties (thiolase, lipase, peptidase and protease activity).

TABLE-US-00003 TABLE 3 DNA PRT Probe SEQ SEQ SEQ ID ID ID UG Gene Accession NO: NO: NO: Description Clone cluster symbol Number Map 1 1 59 calmin (calponin-like, transmembrane) IncytePD: 1464613 Hs.406099 CLMN NM_ 024734 14q32.2 2 2-3 60-61 FK506 binding protein 1B, 12.6 kDa IncytePD: 1288118 Hs.77643 FKBP1B NM_004116 2p24.1 NM_054033 3 4 62 113 kinectin 1 (kinesin receptor) IncytePD: 3736760 AI916662 4 5 63 copine III IncytePD: 3444952 Hs.14158 CPNE3 NM_003909 8q21.13 5 6 64 glutamic-pyruvate transaminase (alanine IncytePD: 1630709 Hs.103502 GPT NM_005309 8q24.3 aminotransferase) 6 7 NO 114 Incyte EST IncytePD: 1607471 7 8 65 filamin B, beta (actin binding protein 278) IncytePD: 1871362 Hs.81008 FLNB NM_001457 3p14.3 8 9 66 villin-like IncytePD: 2804190 Hs.103665 VILL NM_015873 3p21.3 9 10 67 homeo box D9 IncytePD: 2956581 Hs.236646 HOXD9 NM_014213 2q31.1 10 11-12 68-69 CDC42 binding protein kinase alpha IncytePD: 1602261 Hs.18586 CDC42BPA NM_003607 1q42.11 (DMPK-like) NM_014826 11 13-14 70-71 Homo sapiens cDNA FLJ30016 IncytePD: 1570161 Hs.14931 NM_024880 10 fis, clone 3NB692000429. NM_030756 12 15 72 monoglyceride lipase IncytePD: 2174920 Hs.6721 MGLL NM_007283 3q21.3 13 16 73 acetyl-Coenzyme A acyltransferase 1 IncytePD: 1926543 Hs.166160 ACAA1 NM_001607 3p23- (peroxisomal 3-oxoacyl-Coenzyme A p22 thiolase) 14 17 74 115 regulator of G-protein signalling 19 IncytePD: 1626914 Hs.6454 RGS19IP1 AA740666 19p13.1 interacting protein 1 15 18 75 p21/Cdc42/Rac1-activated IncytePD: 2632434 Hs.64056 PAK1 NM_002576 11q13- kinase 1 (STE20 homolog, yeast) q14 16 19 76 motilin IncytePD: 237225 Hs.2813 MLN NM_002418 6p21.3 17 20 77 inositol 1,3,4-triphosphate 5/6 kinase IncytePD: 1967095 Hs.6453 ITPK1 NM_014216 14q31 18 21 78 myosin IA IncytePD: 1502005 Hs.5394 MYO1A AF105424 12q13- q15 19 22 79 116 S164 protein IncytePD: 2047730 Hs.180789 S164 AI400786 14q24.3 20 23 80 protein phosphatase 1, regulatory IncytePD: 2314555 Hs.106019 PPP1R10 NM_002714 6p21.3 subunit 10 21 24 81 KIAA0138 gene product IncytePD: 1731569 Hs.159384 KIAA0138 NM_014649 19p13.3 22 25 82 mucin 5, subtype B, tracheobronchial IncytePD: 1737280 Hs.102482 MUC5B XM_039877 11p15 23 26 83 E74-like, factor 1 (ets domain IncytePD: 1312824 Hs.154365 ELF1 NM_172373 13q13 transcription factor) 24 27 84 metal-regulatory transcription IncytePD: 2467743 Hs.211581 MTF1 NM_005955 1p33 factor 1 25 28 85 small nuclear protein PRAC IncytePD: 2231168 Hs.116467 PRAC BC_030950 17q21 26 29 86 cyclin T1 IncytePD: 2928577 Hs.279906 CCNT1 NM_001240 12pter- qter 27 30-31 87-88 hypothetical protein FLJ12949 IncytePD: 1393595 Hs.184519 FLJ12949 NM_178159 19p13.2 NM_023008 28 32 NO 117 ESTs, Moderately similar to IncytePD: 1222442 Hs.66915 AI934538 22 TRY2_HUMAN Trypsin II precursor (Anionic trypsinogen) [H. sapiens] 29 33 89 Homo sapiens, clone IMAGE: IncytePD: 475497 Hs.355279 NM_022740 7 4797596, mRNA 30 34 90 118 ESTs IncytePD: 1398814 Hs.355960 N41458 12 31 35 91 Homo sapiens, clone IMAGE: IncytePD: 1964852 Hs.427683 BC035712 10 5587702, mRNA 32 36 92 119 WAS protein family, member 2 IncytePD: 1448116 Hs.288908 WASF2 AI094497 1p36.11- p34.3 33 37 93 adaptor-related protein complex 3, IncytePD: 1301192 Hs.75056 AP3D1 NM_003938 19p13.3 delta 1 subunit 34 38 94 protein expressed in thyroid IncytePD: 1807085 Hs.7486 YF13H12 NM_014297 19q13.2 35 39 95 sodium channel, nonvoltage-gated 1, IncytePD: 2121687 Hs.37129 SCNN1B NM_001039 16p12.2- beta (Liddle syndrome) p12.1 36 40 96 KIAA0284 protein IncytePD: 1890138 Hs.182536 KIAA0284 AB006622 14q32.33 37 41 97 deltex homolog 2 (Drosophila) IncytePD: 1691161 Hs.89135 DTX2 NM_020892 7q11.23 38 42 98 myeloid/lymphoid or mixed-lineage IncytePD: 1692195 Hs.199160 MLL BC_036089 11q23 leukemia (trithorax homolog, Drosophila) 39 43 99 chromosome 11 open reading frame 13 IncytePD: 1919646 Hs.72925 C11orf13 NM_003475 11p15.5 40 44 100 small nuclear RNA activating complex, IncytePD: 1445203 Hs.78403 SNAPC2 NM_003083 19p13.3- polypeptide 2, 45 kDa p13.2 41 45 101 SMC1 structural maintenance of IncytePD: 3074894 Hs.211602 SMC1L1 NM_006306 Xp11.22- chromosomes 1-like 1 (yeast) p11.21 42 46 102 LIV-1 protein, estrogen regulated IncytePD: 1402273 Hs.79136 LIV-1 NM_012319 18q12.1 43 47 103 membrane-bound transcription IncytePD: 1302425 Hs.350970 MBTPS2 AF019612 Xp22.1- factor protease, site 2 p22.2 44 48 104 120 ESTs, glutamate-cysteine ligase, IncytePD: 1432207 Hs.315562 GCLM AA805202 1p22.11 modifier subunit 45 49 NO 121 ESTs IncytePD: 4106720 Hs.12876 AA845636 66 46 50 105 hypothetical protein DKFZp762O076 IncytePD: 1967206 Hs.21621 DKFZp762O076 NM_018710 8q21.3 47 51 106 guanylate cyclase 1, soluble, beta 3 IncytePD: 1417408 Hs.77890 GUCY1B3 BC_047620 4q31.3- q33 48 52 107 122 eukaryotic translation initiation factor 5A2 IncytePD: 786494 Hs.104660 EIF5A2 AA134594 3q26.2 49 53 108 interleukin 12A (natural killer cell IncytePD: 2760318 Hs.673 IL12A NM_000882 3p12- stimulatory factor 1, cytotoxic lymphocyte q13.2 maturation factor 1, p35) 50 54 109 hypothetical protein MGC26706 IncytePD: 2706048 Hs.65406 MGC26706 NM_152581 Xp22.31 51 55 NO 123 Incyte EST IncytePD: 2922438 52 56 110 solute carrier family 1 (glial high affinity IncytePD: 3074077 Hs.75379 SLC1A3 Z31713 5p13 glutamate transporter), member 3 53 57 111 serine/threonine kinase 18 IncytePD: 2732630 Hs.172052 STK18 NM_014264 4q27- q28 54 58 112 platelet derived growth factor C IncytePD: 943826 Hs.43080 PDGFC NM_016205 4q32

[0204] List of 54 most significantly changed genes in the class-comparison analysis. UG cluster, unigene cluster. Genes 1-41 are expressed at lower levels in the responders, and genes 42-54 are expressed at higher levels in the responders. Gene 1 is the most statistically significant down-regulated gene and gene 41 is the least statistically significant down-regulated gene. Gene 42 is the most statistically significant up-regulated gene and gene 54 is the least statistically significant up-regulated gene.

[0205] The results of a hierarchical cluster analysis of the 54 genes are presented pictorially in FIG. 2. Fifteen of the 54 genes are particularly highly correlated with the degree of responsiveness to radiochemotherapy (p<0.00032). These genes are indicated as genes 1-12 (down-regulated) and 42-44 (up-regulated).

[0206] Several candidate genes have previously been analyzed by other groups for their potential to serve as predictors for response to radiation or chemotherapy. These include Ku70/80, ERCC1, TP53, DPYD (dihydropyrimidine dehydrogenase), and TYMS (thymidylate synthase). The expression levels of these genes in our analysis, however, were not significantly different in groups of responders or non-responders based on T-level down-sizing.

[0207] The 54 genes whose expression levels were most significantly changed represent members of several cellular pathways and map to multiple different chromosomes. Of particular interest are genes that encode proteins involved in DNA damage repair pathways, such as SMC1, which is involved in the S-phase checkpoint mediated by ATM (Yazdi et al. (2002) Genes Dev 16, 571-82; Kim et al. (2002) Genes Dev 16, 560-70). A number of genes were involved in microtubule organization. For instance, calmin has homology to calponin and dystrophin (Ishisaki et al. (2001) Genomics 74, 172-9). Cdc42 is a member of the Rho GTPase subfamily and triggers microtubule reorganization and cytoskeletal remodeling through GSK-3 and APC, two proteins involved in Wnt-signaling (Etienne-Maimeville et al., (2003) Nature; 421, 753-6; Harwood et al. (2003) Nat Cell Biol 5, 275-7). Filamin B is an integrator of cell mechanics and signaling and acts in the Rho signaling apparatus (Stossel et al. (2001) Nat Rev Mol Cell Biol 2, 138-45); villin proteins are involved in actin metabolism (Athman et al. (2002) Am J Physiol Gastrointest Liver Physiol 283, G496-502); and kinectin 1 is a binding partner of kinesin, and belongs to a class of molecular motors involved in mitoses, axoplasmic transport and secretion (Karcher et al. (2002) Trends Cell Biol 12, 21-7). The preponderance of genes involved in microtubule organization cannot be explained by relative abundance of members of such gene families alone. Again, none of the previously used candidate genes were present in this list.

[0208] From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make changes and modifications of the invention to adapt it to various usage and conditions.

[0209] Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The preceding preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.

[0210] The entire disclosure of all applications, patents and publications, cited above and in the figures are hereby incorporated in their entirety by reference.

Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 123 <210> SEQ ID NO 1 <211> LENGTH: 3118 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 1 gcgcgcccgc cagccaggct ctccgcgccc gccgcccgcg ccgcgctggc ccgggctctc 60 ccgcccgcgc ttcatggctg cacacgagtg ggactggttc caacgcgagg agctcatcgg 120 gcagattagc gacatccgag tgcagaacct gcaagttgag agggaaaatg tgcagaagag 180 gacctttaca cgatggataa atctacatct agaaaagtgc aacccacctc tagaagttaa 240 agatttattc gtcgatatac aagatggcaa aatcctaatg gctttgttag aagtcctgtc 300 tgggcggaat ctgctgcacg aatacaaatc ctcgtcgcat cgtatttttc ggttgaacaa 360 catagcgaaa gcacttaagt ttttggaaga tagcaatgta aaactggtta gcattgatgc 420 agcagaaata gcagatggca acccttcttt ggttcttggg ctgatatgga acataatcct 480 cttcttccag attaaggagc tcacaggcaa cctcagcaga aactctccat cttccagctt 540 gtcccctggc tcagggggca cagactcaga ctcatccttc ccacccacac ccactgcaga 600 gaggagcgtg gcaatatcgg tgaaagacca gaggaaggct atcaaggccc tgttggcgtg 660 ggtgcagagg aaaacgagaa agtatggcgt ggcggtgcag gactttgcgg gcagttggag 720 gagtgggctg gctttcctgg cggtgatcaa ggccattgac cccagcctgg tggacatgaa 780 acaggccctg gaaaattcca cacgagaaaa tctagagaag gctttcagca tcgcacagga 840 tgccctgcac atccccaggc tcctggagcc agaagacatc atggttgaca caccagacga 900 gcagtctatc atgacttacg tggcacagtt tctagaacgt tttccggagt tggaagccga 960 agatattttc gattcagata aagaagttcc tatcgaatcc acttttgttc gcatcaaaga 1020 aactccttct gaacaggaga gcaaagtctt cgttctgact gaaaatgggg agcgtaccta 1080 cactgttaac catgaaacca gccacccacc accctccaaa gtctttgtct gtgacaagcc 1140 cgagagcatg aaggaattcc gcctggatgg tgtttccagc catgcgctgt cagacagctc 1200 caccgagttc atgcaccaga ttattgacca ggtcctgcaa gggggcccag gtaagaccag 1260 cgacatcagt gagccatctc cagaatcctc cattttatca tccagaaagg agaacgggag 1320 gtccaactct ttgccgatca agaaaacagt tcactttgag gctgacacct acaaggatcc 1380 tttctgcagt aagaacctgt ccctttgctt tgaagggagc ccaagagtgg caaaggaatc 1440 attgaggcag gatggacatg tcttggcagt tgaggttgct gaggaaaagg aacagaaaca 1500 ggaatcctcg aagattccag aatcctcctc tgacaaggtc gctggtgaca tttttttggt 1560 ggagggcaca aacaataatt ctcagtcttc ttcctgtaat ggtgctttag agagtacagc 1620 ccgccacgat gaagaaagtc actctctttc acccccagga gaaaatactg tgatggccga 1680 ttccttccag atcaaggtta acctgatgac tgtagaagct ttagaggagg gagactattt 1740 tgaagccatc ccattaaaag cctcaaaatt taacagcgac ctaatagatt ttgcttctac 1800 cagccaggct ttcaacaaag ttccttcacc tcatgagaca aaacctgacg aggatgctga 1860 ggcttttgag aatcatgctg aaaaactagg taaaaggagt attaaatctg ctcacaaaaa 1920 gaaggattcg ccagagcctc aagttaagat ggacaaacat gaacctcatc aggactccgg 1980 agaagaagct gaaggctgtc cttcagcccc agaagagaca ccagtggata aaaagccaga 2040 ggtgcatgaa aaggccaaga gaaagtccac ccgtcctcat tatgaggaag agggagaaga 2100 cgatgacctc cagggtgtgg gcgaggaatt atcttccagc cccccaagca gctgtgtcag 2160 cttggagacc cttgggagtc acagcgaaga aggcctggat ttcaagccct ccccacccct 2220 ctcaaaggtt tccgtcattc cccacgacct cttctatttc ccacactatg aggttcccct 2280 ggctgcagtt ttggaggctt atgtagaaga cccggaggat ctaaaaaatg aagaaatgga 2340 tctcgaagag ccagagggct atatgccaga cctggactcc agggaggagg aggccgatgg 2400 ctctcagagc agctccagtt cctcggtgcc aggagagagc ctccccagtg ccagcgacca 2460 ggtgctgtat ctcagcaggg gtggtgtggg taccacacca gcctcagaac ccgctccact 2520 ggccccccat gaggaccacc agcaaaggga gaccaaagag aatgacccca tggacagcca 2580 tcagtcccag gaatccccaa acctggaaaa catagcaaac cccctagaag aaaatgtaac 2640 gaaagaatca atcagtagta aaaaaaagga aaaaaggaaa catgtggacc acgtagaaag 2700 ttcactattt gtagcaccag gaagtgttca atcctcagat gacctagaag aagacagtag 2760 cgactacagc attccttcca ggactagtca cagtgactcc agcatttacc ttcgacgaca 2820 tactcatagg tcttcggaat cggatcattt tagctatgtt cagttgagga acgcagcaga 2880 tctggatgac agaagaaacc gaatattaac caggaaggcc aacagctcag gagaagccat 2940 gtcactgggg agccacagcc cgcagagtga ctccctgaca cagcttgtcc agcagccgga 3000 tatgatgtat tttattctct tcctgtggct cctggtgtac tgcttgctgc tcttcccaca 3060 actggatgtt agcaggctct gatacgtgtg tctggataat aaaaaagaca ggaccctg 3118 <210> SEQ ID NO 2 <211> LENGTH: 930 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 gcgagccgga gcgacggcgg ggctggggcc ggagccgagc cggggtcggg cagcagcagg 60 gaccccccag aggcggggcc tgtgggaccg ctatgggcgt ggagatcgag accatctccc 120 ccggagacgg aaggacattc cccaagaagg gccaaacgtg tgtggtgcac tacacaggaa 180 tgctccaaaa tgggaagaag tttgattcat ccagagacag aaacaaacct ttcaagttca 240 gaattggcaa acaggaagtc atcaaaggtt ttgaagaggg tgcagcccag atgagcttgg 300 ggcagagggc gaagctgacc tgcacccctg atgtggcata tggagccacg ggccaccccg 360 gtgtcatccc tcccaatgcc accctcatct ttgacgtgga gctgctcaac ttagagtgaa 420 ggcaggaagg aactcaaggt ggtggctgga gatggctgct gctcaccctc ctagcctgct 480 ctgccactgg gacggctcct gcttttgggg ctcttgatca gtgtgctaac ctcactgcct 540 catggcatca tccattctct ctgcccaagt tgctctgtat gtgttcgtca gtgttcatgc 600 gaattcttgc ttgaggaaac ttcggttgca gattgaagca tttcaggttg tgcattttgt 660 gtgatgcatg tagtagcctt tcctgatgac agaacacaga tctcttgttc gcacaatcta 720 cactgcctta ccttcactta aaccacacac acaaggtgct cagacatgaa atgtacatgg 780 cgtaccgtac acagagggac ttgagccagt tacctttgct gtcactttct ctcttataaa 840 ttctgttagc tgctcactta aacaatgtcc tctttgagaa aatgtaaaat aaaggctctg 900 tgcttgacaa aaaaaaaaaa aaaaaaaaaa 930 <210> SEQ ID NO 3 <211> LENGTH: 972 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 3 gcgagccgga gcgacggcgg ggctggggcc ggagccgagc cggggtcggg cagcagcagg 60 gaccccccag aggcggggcc tgtgggaccg ctatgggcgt ggagatcgag accatctccc 120 ccggagacgg aaggacattc cccaagaagg gccaaacgtg tgtggtgcac tacacaggaa 180 tgctccaaaa tgggaagaag tttgattcat ccagagacag aaacaaacct ttcaagttca 240 gaattggcaa acaggaagtc atcaaaggtt ttgaagaggg tgcagcccag ctgggtcctc 300 tttctcctct ccccatctgc ccccatccct gctagatgag cttggggcag agggcgaagc 360 tgacctgcac ccctgatgtg gcatatggag ccacgggcca ccccggtgtc atccctccca 420 atgccaccct catctttgac gtggagctgc tcaacttaga gtgaaggcag gaaggaactc 480 aaggtggctg gagatggctg ctgctcaccc tcctagcctg ctctgccact gggacggctc 540 ctgcttttgg ggctcttgat cagtgtgcta acctcactgc ctcatggcat catccattct 600 ctctgcccaa gttgctctgt atgtgttcgt cagtgttcat gcgaattctt gcttgaggaa 660 acttcggttg cagattgaag catttcaggt tgtgcatttt gtgtgatgca tgtagtagcc 720 tttcctgatg acagaacaca gatctcttgt tcgcacaatc tacactgcct taccttcact 780 taaaccacac acacaaggtg ctcagacatg aaatgtacat ggcgtaccgt acacagaggg 840 acttgagcca gttacctttg ctgtcacttt ctctcttata aattctgtta gctgctcact 900 taaacaatgt cctctttgag aaaatgtaaa ataaaggctc tgtgcttgac aaaaaaaaaa 960 aaaaaaaaaa aa 972 <210> SEQ ID NO 4 <211> LENGTH: 4816 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 cgtcttcccg gtctcctttc ccggccgcac agggtagatt ttcgttccgt cacccaggct 60 ggagtgcagt ggtgtgacct tggcttgctg caaccctttg cctcctgggt tcaagtgatt 120 ctcattgcct cagcctccta agtagctggg attacaggtt ttataggatc acattgacaa 180 aagtaccatg gagttttatg agtcagcata ttttattgtt cttattcctt caatagttat 240 tacagtaatt ttcctcttct tctggctttt catgaaagaa acattatatg atgaagttct 300 tgcaaaacag aaaagagaac aaaagcttat tcctaccaaa acagataaaa agaaagcaga 360 aaagaaaaag aataaaaaga aagaaatcca gaatggaaac ctccatgaat ccgactctga 420 gagtgtacct cgagacttta aattatcaga tgctttggca gtagaagatg atcaagttgc 480 acctgttcca ttgaatgtcg ttgaaacttc aagtagtgtt agggaaagaa aaaagaagga 540 aaagaaacaa aagcctgtgc ttgaagagca ggtcatcaaa gaaagtgacg catcaaagat 600 tcctggcaaa aaagtagaac ctgtcccagt tactaaacag cccacccctc cctctgaagc 660 agctgcctcg aagaagaaac cagggcagaa gaagtctaaa aatggaagcg atgaccagga 720 taaaaaggtg gaaactctca tggtaccatc aaaaaggcaa gaagcattgc ccctccacca 780 agagactaaa caagaaagtg gatcagggaa gaagaaagct tcatcaaaga aacaaaagac 840 agaaaatgtc ttcgtagatg aaccccttat tcatgcaact acttatattc ctttgatgga 900 taatgctgac tcaagtcctg tggtagataa gagagaggtt attgatttgc ttaaacctga 960 ccaagtagaa gggatccaga aatctgggac taaaaaactg aagaccgaaa ctgacaaaga 1020 aaatgctgaa gtgaagttta aagattttct tctgtccttg aagactatga tgttttctga 1080 agatgaggct ctttgtgttg tagacttgct aaaggagaag tctggtgtaa tacaagatgc 1140 tttaaagaag tcaagtaagg gagaattgac tacgcttata catcagcttc aagaaaagga 1200 caagttactc gctgctgtga aggaagatgc tgctgctaca aaggatcggt gtaagcagtt 1260 aacccaggaa atgatgacag agaaagaaag aagcaatgtg gttataacaa ggatgaaaga 1320 tcgaattgga acattagaaa aggaacataa tgtatttcaa aacaaaatac atgtcagtta 1380 tcaagagact caacagatgc agatgaagtt tcagcaagtt cgtgagcaga tggaggcaga 1440 gatagctcac ttgaagcagg aaaatggtat actgagagat gcagtcagca acactacaaa 1500 tcaactggaa agcaagcagt ctgcagaact aaataaacta cgccaggatt atgctaggtt 1560 ggtgaatgag ctgactgaga aaacaggaaa gctacagcaa gaggaagtcc aaaagaagaa 1620 tgctgagcaa gcagctactc agttgaaggt tcaactacaa gaagctgaga gaaggtggga 1680 agaagttcag agctacatca ggaagagaac agcggaacat gaggcagcac agcaagattt 1740 acagagtaaa tttgtggcca aagaaaatga agtacagagt ctgcatagta agcttacaga 1800 taccttggta tcaaaacaac agttggagca aagactaatg cagttaatgg aatcagagca 1860 gaaaagggtg aacaaagaag agtctctaca aatgcaggtt caggatattt tggagcagaa 1920 tgaggctttg aaagctcaaa ttcagcagtt ccattcccag atagcagccc agacctccgc 1980 ttcagttcta gcagaagaat tacataaagt gattgcagaa aaggataagc agataaaaca 2040 gactgaagat tctttagcaa gtgaacgtga tcgtttaaca agtaaagaag aggaacttaa 2100 ggatatacag aatatgaatt tcttattaaa agctgaagtg cagaaattac aggccctggc 2160 aaatgagcag gctgctgctg cacatgaatt ggagaagatg caacaaagtg tttatgttaa 2220 agatgataaa ataagattgc tggaagagca actacaacat gaaatttcaa acaaaatgga 2280 agaatttaag attctaaatg accaaaacaa agcattaaaa tcagaagttc agaagctaca 2340 gactcttgtt tctgaacagc ctaataagga tgttgtggaa caaatggaaa aatgcattca 2400 agaaaaagat gagaagttaa agactgtgga agaattactt gaaactggac ttattcaggt 2460 ggcaactaaa gaagaggagc tgaatgcaat aagaacagaa aattcatctc tgacaaaaga 2520 agttcaagac ttaaaagcta agcaaaatga tcaggtttct tttgcctctc tagttgaaga 2580 acttaagaaa gtgatccatg agaaagatgg aaagatcaag tctgtagaag agcttctgga 2640 ggcagaactt ctcaaagttg ctaacaagga gaaaactgtt caggatttga aacaggaaat 2700 aaaggctcta aaagaagaaa taggaaatgt ccagcttgaa aaggctcaac agttatctat 2760 cacttccaaa gttcaggagc ttcagaactt attaaaagga aaagaggaac agatgaatac 2820 catgaaggct gttttggaag agaaagagaa agacctagcc aatacaggga agtggttaca 2880 ggatcttcaa gaagaaaatg aatctttaaa agcacatgtt caggaagtag cacaacataa 2940 cttgaaagag gcctcttctg catcacagtt tgaagaactt gagattgtgt tgaaagaaaa 3000 ggaaaatgaa ttgaagaggt tagaagccat gctaaaagag agggagagtg atctttctag 3060 caaaacacag ctgttacagg atgtacaaga tgaaaacaaa ttgtttaagt cccaaattga 3120 gcagcttaaa caacaaaact accaacaggc atcttctttt ccccctcatg aagaattatt 3180 aaaagtaatt tcagaaagag agaaagaaat aagtggtctc tggaatgagt tagattcttt 3240 gaaggatgca gttgaacacc agaggaagaa aaacaatgac cttcgggaga aaaactggga 3300 agcaatggaa gcattggcat caactgaaaa aatgctgcag gacaaagtga acaagacttc 3360 caaggaaagg cagcaacagg tggaagctgt tgagttggag gctaaagaag ttctcaaaaa 3420 attatttcca aaggtgtctg tcccttctaa tttgagttat ggtgaatggt tgcatggatt 3480 tgaaaaaaag gcaaaagaat gtatggctgg aacttcaggg tcagaggagg ttaaggttct 3540 agagcacaag ttgaaagaag ctgatgaaat gcacacattg ttacagctag agtgtgaaaa 3600 atacaaatcc gtccttgcag aaacagaagg aattttacag aagctacaga gaagtgttga 3660 gcaagaagaa aataaatgga aagttaaggt cgatgaatca cacaagacta ttaaacagat 3720 gcagtcatca tttacatctt cagaacaaga gctagagcga ttaagaagcg aaaataagga 3780 tattgaaaat ctgagaagag aacgagaaca tttggaaatg gaactagaaa aggcagagat 3840 ggaacgatct acctatgtta cagaagtcag agagctgaaa gatctgttga ctgaattgca 3900 gaaaaaactt gatgattcat attctgaagc agtaagacag aatgaagagc taaatttgtt 3960 gaaggcacag ttaaatgaaa cactcacaaa acttagaact gaacaaaatg aaagacagaa 4020 ggtagctggt gatttgcata aggctcaaca gtcactggag cttatccagt caaaaatagt 4080 aaaagctgct ggagacacta ctgttattga aaatagtgat gtttccccag aaacggagtc 4140 ttctgagaag gagacaatgt ctgtaagtct aaatcagact gtaacacagt tacagcagtt 4200 gcttcaggcg gtaaaccaac agctcacaaa ggagaaagag cactaccagg tgttagagtg 4260 atcatcctct ggcctacctt gacacatgct ctccttcaaa atgctaattc agagtgaagt 4320 aattgggaaa ctgttcattt gaggataaaa aaggcattgt attatatttt gccaaattaa 4380 agccttattt atgttttcac cctttctact ttgtcagaaa cactgaacag agttttgtct 4440 tttctaatcc ttgttagact actgatttaa agaaggaaaa aaaaaagcca actctgtaga 4500 caccttcaga gtttagtttt ataataaaaa ctgtttgaat aattagacct ttacattcct 4560 gaagataaac atgtaatctt ttatcttatt ttgctcaata aaattgttca gaagatcaaa 4620 gtggtaaaga caatgtaaaa tttaacattt taatactgat gttgtacact gttttactta 4680 acattttggg aagtaactgc ctctgacttc aactcaagaa aacacttttt tgttgctaat 4740 gtaatcggtt tttgtaatgg cgtcagcaaa taaaaggatg cttattattc aaaaaaaaaa 4800 aaaaaaaaaa aaaaaa 4816 <210> SEQ ID NO 5 <211> LENGTH: 4737 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5 gtcccagcgt cgctccggac gctgccaacc tgttctccac cgtcgctcga cttccacctc 60 taagactccc acgaaactca ggttgaataa ttcatcaaat tacacaactg aactcaagac 120 atggctgccc agtgtgtcac aaaggtggcg ctgaatgttt cctgtgccaa tcttttggat 180 aaagatatag ggtcaaagtc agacccttta tgtgtgttgt ttttgaatac aagtggtcaa 240 cagtggtatg aggttgagcg cacagaaagg attaagaatt gcttgaatcc ccaattttcc 300 aagacattta ttattgatta ctactttgaa gtggttcaga aattgaaatt tggggtttat 360 gacatcgaca acaaaactat tgagctgagt gatgatgact tcttagggga atgtgaatgt 420 acccttggac aaattgtttc cagcaagaag ctaactcgac cactggtgat gaaaactggc 480 agacctgcag gaaaagggag cattacgatt tcagctgaag aaataaaaga taatagagtg 540 gtcttgtttg aaatggaagc cagaaaactg gataataagg atctatttgg aaagtcagac 600 ccatacctgg aattccacaa gcagacatct gatggaaact ggctaatggt tcatcggaca 660 gaggttgtta aaaacaactt gaatcctgtt tggaggcctt tcaagatctc tcttaactca 720 ctgtgttacg gagatatgga caaaaccatt aaggtggagt gttatgatta tgacaatgat 780 gggtcacatg atctcattgg aacatttcag accaccatga caaaactgaa agaagcctcc 840 agaagctcac ctgttgaatt tgaatgcata aatgagaaaa aaaggcaaaa gaaaaaaagc 900 tacaagaatt caggtgttat cagtgtgaaa cagtgtgaga ttacagtaga atgcacattc 960 cttgactata taatgggagg atgtcagctg aattttactg tgggagtgga cttcactggc 1020 tccaatggtg acccaaggtc tccagactcc cttcattaca tcagccccaa tggcgttaat 1080 gagtatttga ctgctctctg gtctgtggga ctggtcattc aagattatga tgctgataag 1140 atgtttccag cttttggttt tggcgctcag atacctcctc agtggcaggt atcacatgaa 1200 tttccaatga acttcaaccc atccaatccc tactgcaatg gaatccaagg cattgtagag 1260 gcgtatcggt cttgtcttcc tcagataaaa ctctatggac caactaattt ttctccaatc 1320 ataaatcacg tggccaggtt tgctgctgca gccacgcaac agcagacagc ttctcaatat 1380 tttgtgcttt tgattattac tgatggtgtg atcacagacc ttgatgaaac cagacaagct 1440 atagttaatg cctccaggct gcctatgtcc atcataattg ttggagttgg aggtgctgac 1500 ttcagcgcca tggagtttct ggatggtgat ggtggaagtc tccgctcccc attgggcgaa 1560 gtggccatca gagatattgt ccagtttgtg cctttcagac agttccagaa tgctccaaaa 1620 gaagcacttg ctcagtgtgt cttggcagag attccccagc aggtggtggg ctacttcaat 1680 acatacaaac tccttcctcc caagaaccca gccacgaaac aacagaagca gtgaccactt 1740 caacagaatt cttttgtgtt atgtggagca atgccatctc tcaccccaaa tcgtgtatct 1800 gtcattctac gtacttttta cccccagcat ttatgatgta aatctctttc tctatggatt 1860 atatctgttt aaagcattct ttctaggtta ttttgggggg acagtgccaa gtccatcttt 1920 gcccagtcaa ttcagtgatt gatagcaatt tacattaatt gcagtaaagc tctttggatt 1980 agaaattagt gtggggaaag cttattctgt tgttgttttt gtttactttc atatgatgaa 2040 aatgctgtgt ttaagtgttt gtcaatagga agaatggaaa actgttggga tgatgtggtt 2100 tgcaggttgc tgtgcctgat tcacagtgta tgttgtataa gccaatgtcc atacctgatt 2160 atgagagctt cttaaattat atgatatcaa atttgttcct gtaactctgt atacagtgct 2220 tttctgcaag gtaaaaataa cctgtctatg catctgattt ttgctacagt ttagacactg 2280 tggtttacaa aacagcatgc actcaacttg ggactttatg aaaagtactg aatgagcagg 2340 aaaaggcgca tactcagttt tttaaatgta caatcaacaa gtaaaaataa cctcatgtaa 2400 gtaagccatt tttatttgcc tttctagata ttttatttta ttgtggaaaa ctgtaaacat 2460 ggtcagattt ggcttttttt ttcattaact gagcaagact ttcaggatat tgtagatgca 2520 cagatggtag gttgtcctga attctacatt attagattac tttaattgag atttgttaaa 2580 acggttagga ctgttttgtc caggaaagat aagaggacca aacatataag gtgaaattca 2640 gaattccgtt tccttctaac taatgaaaaa ctgcttacta aaaaaaaatt ttatactttc 2700 cttgctaagg tcccatatat tgatttgtac agatccactt agtcattttc tccttttttt 2760 aagaaccatt ttcatctgat ttttaaactc acgataccag ttatctgtta atcaaaattg 2820 cattttacaa tttaataatg tgatatttcc tatgtctaca gcatacctta ttaggtataa 2880 aacctactgc aacttagaaa aaggaaagaa aaaagaagac ttttccaact gctgcattaa 2940 gatagggtgg attttatgtg cttttttttt ttaagagttg aatttctttt cctgactttt 3000 accttttaca gcgtattact tagtgaacat tacattttca gaatagatcc taatatttta 3060 ttgagggcct atgtgctaaa aactatgcat atctatatat tggccaatta tctttaataa 3120 tttacctttt gaaattgcat gtttatcata tatccttaag tggacacata cagtgccatg 3180 ttgatgtgcc tctcagtttt attgaaaagc tgccccacag cccatgtctc ttgttctctg 3240 caatgcctca agggagtgag ctctcaacca cagatagctg tggcttctca gaagcagctc 3300 attgccaagg ccaggctgag aggggacctg cttgctgtgg tggttgccta gcccagatga 3360 gcatttacct accaccttcc cacttggcta gctgtccttt ggatatgtgc tgttaactgg 3420 ggaaggcatc taactagtag cctgctactc catagtatgg ctcaatagat gacacatcat 3480 tttgacatta tcaataggag aaaagaaaac taacccttct tctgattgtt tggagccata 3540 gttgtctcag atgttctaat tctctttgta tgcttggaaa cagcatagat atgttgctgt 3600 ggttttcaga attttctctt ttaatcacaa gaagcctttt aaaaaatgac ttacacatat 3660 tctcaatgta cagtaaaaca gacagaagtg agcttatctg tttgatgctg tggcagggtc 3720 ccagtcactg ggcatatcct ccttctcctt aaccagcttc tcagcagccc ctgagtcacc 3780 tgcacaaggt gcttgggaac tgctggttat gagcattcct ggttttcttc agccaaataa 3840 caggtaatca ctgtcaattg gatttggtct tcattatttt atattctgat tttatcagaa 3900 ttattctatt ttaaaattgt tttaaaattt aaaaacattt aattcatgat catgttcatc 3960 agtagatgct attattcata agaactgtga ttccagcaaa ctagggtaat tggtgccttt 4020 ttacagtttt gaataaaagc atttacaatt tctaaattat cagttttcac agtttcagca 4080 ctcaacctca tcatacgctg atttaatatt gttttacatt aaaatagtcc ttttccctgt 4140 tgtgccacca ttcatttaag tgctgtttgt tcttaaaatg catttaaaga aaaattaccc 4200 atattgactt tcacacctca tataatcaga tctattacaa atatatatcg gagtgacggt 4260 gcccaggata gatgtaatat ttcttacaga tgctggcaca gaggaaataa tataccagct 4320 aatctagtca cctaaccttg tggttagaat tgcaatttta agaccagaaa aatttgaagt 4380 ctgatcagag atttacaact gttcattata gtggtgcctt aggcaatctt tccaaagtaa 4440 attcagggcc ccattgctac ttatgccata tttggacata cttttttttt cttcaatttt 4500 gtaaacttcc tggaaagctg tcttcactaa gtatccccta gtctctatat atgtggttag 4560 tagtcatgga aatgacacat aaagtacgcc agaagtttga tggaacgtgt tagaaactgt 4620 tttgtgcttt tatggatgtc atacttgaca atacatgtgt aagttactaa tatatgaatt 4680 gatgctaaat atatcttaca tttgaattcc ttttggataa agttatttct tgatgtg 4737 <210> SEQ ID NO 6 <211> LENGTH: 1924 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 ccccgccttc acccactgcc tctgcctccc tggggcagag ctgtttccca gacgggtggg 60 gcggggccca actgtcccag ctccttcagc cctttctgtc cctcccagtg aggccagctg 120 cggtgaagag ggtgctctct tgcctggcgt tccctctgca cggctgcccc ctcccaccct 180 gcccactaag ccagacccac tgtcgccatt cccacttctg gtcctgccac ctcctgagct 240 gccttcccgc ctggtctggg tagagtcatg gcctcgagca caggtgaccg gagccaggcg 300 gtgaggcatg gactgagggc gaaggtgctg acgctggacg gcatgaaccc gcgtgtgcgg 360 agagtggagt acgcagtgcg tggccccata gtgcagcgag ccttggagct ggagcaggag 420 ctgcgccagg gtgtgaagaa gcctttcacc gaggtcatcc gtgccaacat cggggacgca 480 caggctatgg ggcagaggcc catcaccttc ctgcgccagg tcttggccct ctgtgttaac 540 cctgatcttc tgagcagccc caacttccct gacgatgcca agaaaagggc ggagcgcatc 600 ttgcaggcgt gtgggggcca cagtctgggg gcctacagcg tcagctccgg catccagctg 660 atccgggagg acgtggcgcg gtacattgag aggcgtgacg gaggcatccc tgcggacccc 720 aacaacgtct tcctgtccac aggggccagc gatgccatcg tgacggtgct gaagctgctg 780 gtggccggcg agggccacac acgcacgggt gtgctcatcc ccatccccca gtacccactc 840 tactcggcca cgctggcaga gctgggcgca gtgcaggtgg attactacct ggacgaggag 900 cgtgcctggg cgctggacgt ggccgagctt caccgtgcac tgggccaggc gcgtgaccac 960 tgccgccctc gtgcgctctg tgtcatcaac cctggcaacc ccaccgggca ggtgcagacc 1020 cgcgagtgca tcgaggccgt gatccgcttc gccttcgaag agcggctctt tctgctggcg 1080 gacgaggtgt accaggacaa cgtgtacgcc gcgggttcgc agttccactc attcaagaag 1140 gtgctcatgg agatggggcc gccctacgcc gggcagcagg agcttgcctc cttccactcc 1200 acctccaagg gctacatggg cgagtgcggg ttccgcggcg gctatgtgga ggtggtgaac 1260 atggacgctg cagtgcagca gcagatgctg aagctgatga gtgtgcggct gtgcccgccg 1320 gtgccaggac aggccctgct ggacctggtg gtcagcccgc ccgcgcccac cgacccctcc 1380 tttgcgcagt tccaggctga gaagcaggca gtgctggcag agctggcggc caaggccaag 1440 ctcaccgagc aggtcttcaa tgaggctcct ggcatcagct gcaacccagt gcagggcgcc 1500 atgtactcct tcccgcgcgt gcagctgccc ccgcgggcgg tggagcgcgc tcaggagctg 1560 ggcctggccc ccgatatgtt cttctgcctg cgcctcctgg aggagaccgg catctgcgtg 1620 gtgccaggga gcggctttgg gcagcgggaa ggcacctacc acttccggat gaccattctg 1680 ccccccttgg agaaactgcg gctgctgctg gagaagctga gcaggttcca tgccaagttc 1740 accctcgagt actcctgagc accccagctg gggccaggct gggtcgccct ggactgtgtg 1800 ctcaggagcc ctgggaggct ctggagccca ctgtacttgc tcttgatgcc tggcggggtg 1860 gggtgggggg ggtgctgggc ccctgcctct ctgcaggtcc ctaataaagc tgtgtggcag 1920 tctg 1924 <210> SEQ ID NO 7 <211> LENGTH: 1924 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 7 ccccgccttc acccactgcc tctgcctccc tggggcagag ctgtttccca gacgggtggg 60 gcggggccca actgtcccag ctccttcagc cctttctgtc cctcccagtg aggccagctg 120 cggtgaagag ggtgctctct tgcctggcgt tccctctgca cggctgcccc ctcccaccct 180 gcccactaag ccagacccac tgtcgccatt cccacttctg gtcctgccac ctcctgagct 240 gccttcccgc ctggtctggg tagagtcatg gcctcgagca caggtgaccg gagccaggcg 300 gtgaggcatg gactgagggc gaaggtgctg acgctggacg gcatgaaccc gcgtgtgcgg 360 agagtggagt acgcagtgcg tggccccata gtgcagcgag ccttggagct ggagcaggag 420 ctgcgccagg gtgtgaagaa gcctttcacc gaggtcatcc gtgccaacat cggggacgca 480 caggctatgg ggcagaggcc catcaccttc ctgcgccagg tcttggccct ctgtgttaac 540 cctgatcttc tgagcagccc caacttccct gacgatgcca agaaaagggc ggagcgcatc 600 ttgcaggcgt gtgggggcca cagtctgggg gcctacagcg tcagctccgg catccagctg 660 atccgggagg acgtggcgcg gtacattgag aggcgtgacg gaggcatccc tgcggacccc 720 aacaacgtct tcctgtccac aggggccagc gatgccatcg tgacggtgct gaagctgctg 780 gtggccggcg agggccacac acgcacgggt gtgctcatcc ccatccccca gtacccactc 840 tactcggcca cgctggcaga gctgggcgca gtgcaggtgg attactacct ggacgaggag 900 cgtgcctggg cgctggacgt ggccgagctt caccgtgcac tgggccaggc gcgtgaccac 960 tgccgccctc gtgcgctctg tgtcatcaac cctggcaacc ccaccgggca ggtgcagacc 1020 cgcgagtgca tcgaggccgt gatccgcttc gccttcgaag agcggctctt tctgctggcg 1080 gacgaggtgt accaggacaa cgtgtacgcc gcgggttcgc agttccactc attcaagaag 1140 gtgctcatgg agatggggcc gccctacgcc gggcagcagg agcttgcctc cttccactcc 1200 acctccaagg gctacatggg cgagtgcggg ttccgcggcg gctatgtgga ggtggtgaac 1260 atggacgctg cagtgcagca gcagatgctg aagctgatga gtgtgcggct gtgcccgccg 1320 gtgccaggac aggccctgct ggacctggtg gtcagcccgc ccgcgcccac cgacccctcc 1380 tttgcgcagt tccaggctga gaagcaggca gtgctggcag agctggcggc caaggccaag 1440 ctcaccgagc aggtcttcaa tgaggctcct ggcatcagct gcaacccagt gcagggcgcc 1500 atgtactcct tcccgcgcgt gcagctgccc ccgcgggcgg tggagcgcgc tcaggagctg 1560 ggcctggccc ccgatatgtt cttctgcctg cgcctcctgg aggagaccgg catctgcgtg 1620 gtgccaggga gcggctttgg gcagcgggaa ggcacctacc acttccggat gaccattctg 1680 ccccccttgg agaaactgcg gctgctgctg gagaagctga gcaggttcca tgccaagttc 1740 accctcgagt actcctgagc accccagctg gggccaggct gggtcgccct ggactgtgtg 1800 ctcaggagcc ctgggaggct ctggagccca ctgtacttgc tcttgatgcc tggcggggtg 1860 gggtgggggg ggtgctgggc ccctgcctct ctgcaggtcc ctaataaagc tgtgtggcag 1920 tctg 1924 <210> SEQ ID NO 8 <211> LENGTH: 9432 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 gccgtggctc cggtagcagc aagttcgaac cccgctcccg ctccgcttcg gttctcgctc 60 cttcggccct tgggcctcca aacaccagtc cccggcagct cgttgcgcat tgcgctctcc 120 ccgccaccag gatgccggta accgagaagg atctagctga ggacgcgcct tggaagaaga 180 tccagcagaa cacgttcaca cgctggtgca acgagcacct caagtgcgtg aacaaacgca 240 tcggcaacct gcagaccgac ctgagcgacg ggctgcggct catcgcgctg ctcgaggtgc 300 tcagccagaa gcgcatgtac cgcaagtacc atcagcggcc cacctttcgc cagatgcagc 360 tcgagaatgt gtccgtggcg ctcgagttcc tggaccgtga gagcatcaag ctcgtgtcca 420 tcgatagcaa agccattgtg gatgggaacc tgaagctcat cttgggtctg gtgtggacgc 480 tgatcctcca ctactccatc tccatgcccg tgtgggagga tgaaggggat gatgatgcca 540 agaagcagac gccaaagcag aggctgctgg ggtggattca gaacaagatc ccctacttgc 600 ccatcaccaa ctttaaccag aactggcaag acggcaaagc cctgggagcc ctggtagaca 660 gctgtgctcc aggtctgtgc ccagactggg aatcctggga cccgcagaag cctgtggata 720 atgcacgaga agccatgcag caggcagatg actggctggg tgtcccacag gtcatcactc 780 ctgaagaaat cattcacccg gatgtggacg agcactcagt tatgacttac ctgtcccagt 840 tccccaaagc caagctcaag ccgggggctc ctctcaaacc caaactcaac ccgaagaaag 900 ccagggccta tggcagagga atcgagccca ctggaaacat ggtgaagcag ccagccaagt 960 tcactgtgga caccatcagc gccgggcaag gagacgtgat ggtgtttgtt gaggacccag 1020 aagggaacaa agaggaggca caagtgaccc ctgacagcga caagaacaag acatactctg 1080 tggagtatct gcccaaggtc accgggctac acaaagtcac agtcctcttt gcaggacagc 1140 acatctccaa gagcccattt gaagtgagtg ttgacaaggc ccagggagat gccagtaaag 1200 tcactgcaaa aggtccaggg ttggaagctg tagggaacat cgccaataag cccacctact 1260 ttgacatcta tacggcagga gctggtgtgg gtgacattgg tgtggaggtg gaagatcccc 1320 aggggaagaa caccgtggag ttgctcgtgg aagacaaagg aaaccaggtg tatcgatgtg 1380 tgtacaaacc catgcagcct ggccctcacg tggtcaagat cttctttgct ggggacacta 1440 ttcctaagag tcccttcgtt gtgcaggttg gggaagcctg caatccaaat gcctgccggg 1500 ccagtggccg aggcctacaa cccaaaggcg tccgtatccg ggagaccaca gatttcaagg 1560 ttgacaccaa agctgcagga agtggggagc tcggggtaac catgaagggt cctaagggtc 1620 tggaggagct ggtgaagcag aaagactttc tggatggggt ctacgcattc gagtattacc 1680 ccagcacccc ggggagatac agcattgcca tcacatgggg gggacaccac attccaaaga 1740 gcccctttga agttcaagtt ggccctgaag cgggtatgca gaaagtccgt gcttggggcc 1800 ctgggctcca tggtgggatt gtcgggcggt cagcggactt cgtggtagaa tccattggct 1860 ctgaagtggg gtctctgggg tttgccattg aaggcccctc tcaggcaaag attgagtaca 1920 acgaccagaa tgatggatcg tgtgatgtca aatactggcc caaggagcct ggcgaatatg 1980 ctgttcacat catgtgtgac gacgaagaca tcaaggacag cccgtacatg gccttcatcc 2040 acccagccac gggaggctac aaccctgatc tggttcgagc atacgggcca ggtttggaga 2100 aatctggatg cattgtcaac aacctggccg agttcactgt ggatcctaag gatgctggaa 2160 aagctccctt aaagatattt gctcaggatg gggaaggcca acgcattgac atccagatga 2220 agaaccggat ggacggcaca tatgcatgct catacacccc ggtgaaggcc atcaagcaca 2280 ccattgctgt ggtctgggga ggcgtgaaca tcccgcacag cccctacagg gtcaacatcg 2340 ggcaaggtag ccatcctcag aaggtcaaag tgtttgggcc aggtgtggag agaagtggtc 2400 tgaaggcaaa tgaacctaca cacttcacgg tggactgtac tgaggctggg gaaggtgatg 2460 tcagtgttgg cattaagtgt gatgcccggg tgttaagtga agatgaggaa gacgtggatt 2520 ttgacattat tcacaatgcc aatgatacgt tcacagtcaa atatgtgcct cctgctgctg 2580 ggcgatacac tatcaaagtt ctctttgcat ctcaggaaat ccccgccagc cctttcagag 2640 tcaaagttga cccttcccac gatgccagca aagtgaaggc agaaggccca gggctcagca 2700 aagcaggtgt ggaaaatggg aaaccgaccc acttcactgt ctacaccaag ggggctggga 2760 aagccccgct caacgtgcag ttcaacagcc ctcttcctgg cgatgcagtg aaggatttgg 2820 atatcatcga taattatgac tactctcaca cggttaaata tacacccacc caacagggca 2880 acatgcaggt tctggtgact tacggtggcg atcccatccc taaaagccct ttcactgtgg 2940 gtgttgctgc accgctggat ctgagcaaga taaaactcaa tgggctggaa aacagggtgg 3000 aagttgggaa ggatcaggag ttcaccgttg ataccagggg ggcaggaggc caggggaagc 3060 tggacgtgac aatcctcagc ccctctcgga aggtcgtgcc atgcctagtg acacctgtga 3120 caggccggga gaacagcacg gccaagttca tccctcggga ggaggggctg tatgctgtag 3180 acgtgaccta cgatggacac cctgtgcccg ggagccccta cacagtggag gcctcgctgc 3240 caccagatcc cagcaaggtg aaggcccacg gtcccggcct cgaaggtggt ctcgtgggca 3300 agcctgccga gttcaccatc gataccaaag gagctggtac tggaggtctg ggcttaacgg 3360 tggaaggtcc gtgcgaggcc aaaatcgagt gctccgacaa tggtgatggg acctgctccg 3420 tctcttacct tcccacaaaa cccggggagt acttcgtcaa catcctcttt gaagaagtcc 3480 acatacctgg gtctcccttc aaagctgaca ttgaaatgcc ctttgacccc tctaaagtcg 3540 tggcatcggg gccaggtctc gagcacggga aggtgggtga agctggcctc cttagcgtca 3600 actgctcgga agcgggaccg ggggccctgg gcctggaagc tgtctcggac tcgggaacaa 3660 aagccgaagt cagtattcag aacaacaaag atggcaccta cgcggtgacc tacgtgcccc 3720 tgacggccgg catgtacacg ttgaccatga agtatggtgg cgaactcgtg ccacacttcc 3780 ccgcccgggt caaggtggag cccgccgtgg acaccagcag gatcaaagtc tttggaccag 3840 gaatagaagg gaaagatgtg ttccgggaag ctaccaccga ctttacagtt gactctcggc 3900 cgctgaccca ggttgggggt gaccacatca aggcccacat tgccaacccc tcaggggcct 3960 ccaccgagtg ctttgtcaca gacaatgcgg atgggaccta ccaggtggaa tacacaccct 4020 ttgagaaagg tctccatgta gtggaggtga catatgatga cgtgcctatc ccaaacagtc 4080 ccttcaaggt ggctgtcact gaaggctgcc agccatctag ggtgcaagcc caaggacctg 4140 gattgaaaga ggcctttacc aacaagccca atgtcttcac cgtggttacc agaggcgcag 4200 gaattggtgg gcttggcata actgttgagg gaccatcaga gtcgaagata aattgcagag 4260 acaacaagga tggcagctgc agtgctgagt acattccttt cgcgccgggg gattacgatg 4320 ttaatatcac atatggagga gcccacatcc ctggcagccc cttcagggtt cctgtgaagg 4380 atgttgtgga ccccagcaag gtcaagattg ccggccccgg gctgggctca ggcgtccgag 4440 cccgtgtcct gcagtccttc acggtggaca gcagcaaggc tggcctggct ccgctggaag 4500 tgagggttct gggcccacga ggcttggtgg agccagtgaa catggtggac aatggagatg 4560 gcacacacac agtaacctac accccatctc aggagggacc ttacatggtc tcagttaaat 4620 atgctgatga agagattcct cgcagtccct tcaaggtcaa ggtccttccc acatatgatg 4680 ccagcaaagt gactgccagt ggccccggcc ttagttccta tggtgtgcct gccagtctac 4740 ctgtggactt tgcaattgat gcccgagatg ccggggaagg cctgcttgct gttcaaataa 4800 cggaccaaga aggaaaaccc aaaagagcca ttgtccatga caataaagat ggcacgtatg 4860 ctgtcaccta catccccgac aagactgggc gctatatgat tggagtcacc tacgggggtg 4920 acgacatccc actttctcct tatcgcatcc gagccacaca gacgggtgat gccagcaagt 4980 gcctggccac gggtcctgga atcgcctcca ctgtgaaaac tggcgaagaa gtaggctttg 5040 tggttgatgc caagactgcc gggaagggta aagtgacctg cacggttctg accccagatg 5100 gcactgaggc cgaggccgat gtcattgaga atgaagatgg aacctatgac atcttctaca 5160 cagctgccaa gccgggcaca tatgtgatct atgtgcgctt cggtggtgtt gatattccta 5220 acagcccctt cactgtcatg gccacagatg gggaagtcac agccgtggag gaggcaccgg 5280 taaatgcatg tccccctgga ttcaggccct gggtgaccga agaggcctat gtcccagtga 5340 gtgacatgaa cggcctggga tttaagcctt ttgacctggt cattccgttt gctgtcagga 5400 aaggagaaat cactggagag gtccacatgc cttctgggaa gacagccaca cctgagattg 5460 tggacaacaa ggacggcacg gtcactgtta gatatgcccc cactgaggtc gggctccatg 5520 agatgcacat caaatacatg ggcagccaca tccctgagag cccactccag ttctacgtga 5580 actaccccaa cagtggaagt gtttctgcat acggtccagg cctcgtgtat ggagtggcca 5640 acaaaactgc caccttcacc atcgtcacag aggatgcagg agaaggtggt ctggacttgg 5700 ctattgaggg cccctcaaaa gcagaaatca gctgcattga caataaagat gggacatgca 5760 cagtgaccta cctgccgact ctgccaggcg actacagcat tctggtcaag tacaatgaca 5820 agcacatccc tggcagcccc ttcacagcca agatcacaga tgacagcagg cggtgctccc 5880 aggtgaagtt gggctcagcc gctgacttcc tgctcgacat cagtgagact gacctcagca 5940 gcctgacggc cagcattaag gccccatctg gccgagacga gccctgtctc ctgaagaggc 6000 tgcccaacaa ccacattggc atctccttca tcccccggga agtgggcgaa catctggtca 6060 gcatcaagaa aaatggcaac catgtggcca acagccccgt gtctatcatg gtggtccagt 6120 cggagattgg tgacgcccgc cgagccaaag tctatggccg cggcctgtca gaaggccgga 6180 ctttcgagat gtctgacttc atcgtggaca caagggatgc aggttatggt ggcatatcct 6240 tggcggtgga aggccccagc aaagtggaca tccagacgga ggacctggaa gatggcacct 6300 gcaaagtctc ctacttccct accgtgcctg gggtttatat cgtctccacc aaattcgctg 6360 acgagcacgt gcctgggagc ccatttaccg tgaagatcag tggggaggga agagtcaaag 6420 agagcatcac ccgcaccagt cgggccccgt ccgtggccac tgtcgggagc atttgtgacc 6480 tgaacctgaa aatcccagaa atcaacagca gtgatatgtc ggcccacgtc accagcccct 6540 ctggccgtgt gactgaggca gagattgtgc ccatggggaa gaactcacac tgcgtccggt 6600 ttgtgcccca ggagatgggc gtgcacacgg tcagcgtcaa gtaccgtggg cagcacgtca 6660 ccggcagccc cttccagttc accgtggggc cacttggtga aggaggcgcc cacaaggtgc 6720 gggcaggagg ccctggcctg gagagaggag aagcgggagt cccagctgag ttcagcattt 6780 ggacccggga agcaggcgct ggaggcctct ccatcgctgt tgagggcccc agtaaggccg 6840 agattacatt cgatgaccat aaaaatgggt cgtgcggtgt atcttatatt gcccaagagc 6900 ctggtaacta cgaggtgtcc atcaagttca atgatgagca catcccggaa agcccctacc 6960 tggtgccggt catcgcaccc tccgacgacg cccgccgcct cactgttatg agccttcagg 7020 aatcgggatt aaaagttaac cagccagcat cctttgctat aaggttgaat ggcgcaaaag 7080 gcaagattga tgcaaaggtg cacagcccct ctggagccgt ggaggagtgc cacgtgtctg 7140 agctggagcc agataagtat gctgttcgct tcatccctca tgagaatggt gtccacacca 7200 tcgatgtcaa gttcaatggg agccacgtgg ttggaagccc cttcaaagtg cgcgttgggg 7260 agcctggaca agcggggaac cctgccctgg tgtccgccta tggcacggga ctcgaagggg 7320 gcaccacagg tatccagtcg gaattcttta ttaacaccac ccgagcaggt ccagggacat 7380 tatccgtcac catcgaaggc ccatccaagg ttaaaatgga ttgccaggaa acacctgaag 7440 ggtacaaagt catgtacacc cccatggctc ctggtaacta cctgatcagt gtcaaatacg 7500 gtgggcccaa ccacatcgtg ggcagtccct tcaaggccaa ggtgacaggc cagcgtctag 7560 ttagccctgg ctcagccaac gagacctcat ccatcctggt ggagtcagtg accaggtcgt 7620 ctacagagac ctgctatagc gccattccca aggcatcctc ggacgccagc aaggtgacct 7680 ctaagggggc agggctctca aaggcctttg tgggccagaa gagttccttc ctggtggact 7740 gcagcaaagc tggctccaac atgctgctga tcggggtcca tgggcccacc accccctgcg 7800 aggaggtctc catgaagcat gtaggcaacc agcaatacaa cgtcacatac gtcgtcaagg 7860 agaggggcga ttatgtgctg gctgtgaagt ggggggagga acacatccct ggcagccctt 7920 ttcatgtcac agtgccttaa aacagttttc tcaaatcctg gagagagttc ttgtggttgc 7980 ttttgttgct tgtttgtaat tcattttata caaagccctc cagcctgttt gtggggctga 8040 aaccccatcc ctaaaatatt gctgttgtaa aatgccttca gaaataagtc ctagactgga 8100 ctcttgaggg acatattgga gaatcttaag aaatgcaagc ttgttcaggg ggctgagaag 8160 atcctgagta cactaggtgc aaaccagaac tcttggtgga acagaccagc cactgcagca 8220 gacagaccag gaacacaatg agactgacat ttcaaaaaaa caaaactggc tagcctgagc 8280 tgctggttca ctcttcagca tttatgaaac aaggctaggg gaagatgggc agagaaaaag 8340 gggacaccta gtttggttgt catttggcaa aggagatgac ttaaaatccg cttaatctct 8400 tccagtgtcc gtgttaatgt atttggctat tagatcacta gcactgcttt accgctcctc 8460 atcgccaaca cccccatgct ctgtggcctt cttacacttc tcagagggca gagtggcagc 8520 cgggcaccct acagaaactc agagggcaga gtggcagcca ggcccacatg tctctcaagt 8580 acctgtcccc tcgctctggt gattatttct tgcagaatca ccacacgaga ccatcccggc 8640 agtcatggtt ttgctttagt tttccaagtc cgtttcagtc ccttccttgg tctgaagaaa 8700 ttctgcagtg gcgagcagtt tcccacttgc caaagatccc ttttaaccaa cactagccct 8760 tgtttttaac acacgctcca gcccttcatc agcctgggca gtcttaccaa aatgtttaaa 8820 gtgatctcag aggggcccat ggattaacgc cctcatccca aggtccgtcc catgacataa 8880 cactccacac ccgccccagc caacttcatg ggtcactttt tctggaaaat aatgatctgt 8940 acagacagga cagaatgaaa ctcctgcggc tctttggcct gaaagttggg aatggttggg 9000 ggagagaagg gcagcagctt attggtggtc ttttcaccat tggcagaaac agtgagagct 9060 gtgtggtgca gaaatccaga aatgaggtgt agggaatttt gcctgccttc ctgcagacct 9120 gagctggctt tggaatgagg ttaaagtgtc agggacgttg cctgagccca aatgtgtagt 9180 gtggtctggg caggcagacc tttaggtttt gctgcttagt cctgaggaag tggccactct 9240 tgtggcaggt gtagtatctg gggcgagtgt tgggggtaaa agcccaccct acagaaagtg 9300 gaacagcccg gacctgatgt gaaaggacca cgggtgttgt aagctgggac cggaaccaaa 9360 ctggaatcaa acgcgactgt aaattgtatc ttataactta ttaaataaaa cattgctccg 9420 taaaaaaaaa aa 9432 <210> SEQ ID NO 9 <211> LENGTH: 2193 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 9 cgatgatgat tcagtggaat gggcccaaga ccagcatttc tgagaaggct cgggggctgg 60 ctttgaccta cagcctccgg gacagggaac gtggtggtgg tcgtgcacag attggtgtgg 120 tggatgatga ggccaaagcc ccggacctca tgcagatcat ggaggctgtg ctgggctgca 180 gggtgggcag cctgcgtgcc gccacgccca gcaaggatat caaccagctg cagaaggcca 240 atgttcgcct gtaccatgtc tatgagaagg gcaaagacct ggtggtcctg gagttggcga 300 cccccccact gacccaggac ctgctgcagg aggaggactt ctacatcctg gaccagggtg 360 gcttcaagat ctatgtgtgg cagggacgca tgtctagcct ccaggagaga aaggctgcct 420 tcagccgggc tgtgggcttc atccaggcca agggctaccc gacctacacc aacgtggagg 480 tggtgaacga cggcgccgag tcggccgcgt tcaagcagct cttccggact tggtctgaga 540 agcggcgcag gaaccagaag ctcggcggga gggataaatc gattcatgta aagctggacg 600 tgggcaagct gcacacccag cctaagttag cggcccagct caggatggtg gacgacggct 660 ctgggaaggt ggaggtgtgg tgcatccagg acttacacag gcagcccgtg gaccccaagc 720 gtcatggaca gctgtgtgca ggcaactgct accttgtgct ctacacatac cagaggctgg 780 gccgtgttca gtacatcctg tacctatggc agggccacca ggccactgcg gatgagattg 840 aggccctgaa cagcaacgct gaggaactag atgtcatgta tggtggcgtc ctagtacagg 900 agcatgtgac catgggcagc gagccccccc acttcctcgc catcttccag ggccagctgg 960 tgatcttcca ggagagagct gggcaccatg gaaaggggca gtcagcatcc accacaaggc 1020 ttttccaagt gcaaggcact gacagccaca acaccaggac catggaggtg ccagcccgtg 1080 cctcatccct caactccagt gacatcttct tgctggtcac agccagcgtc tgctacctct 1140 ggtttgggaa gggctgtaat ggtgatcagc gtgagatggc acgggtggtg gtcactgtca 1200 tttccaggaa gaatgaggaa acggtgctgg agggtcagga gcctccccac ttctgggagg 1260 ccctgggagg ccgggccccc taccccagca acaagaggct ccctgaggag gtccccagct 1320 tccagccacg actgtttgag tgctccagcc acatgggctg cctggtcctc gcagaagtgg 1380 ggttcttcag ccaggaggac ctggacaagt atgacatcat gttactggac acctggcagg 1440 agatcttcct gtggcttggg gaagctgcaa gtgagtggaa ggaggcggtg gcctggggcc 1500 aggagtacct gaagactcac ccagcaggga ggagcccggc cacacccatc gtgctggtca 1560 agcagggcca tgagcctccc accttcattg gatggttctt cacttgggac ccctacaagt 1620 ggactagcca cccgtcccac aaggaagtgg tggatggcag cccggcagca gcatcaacca 1680 tctctgagat aacagcagaa gtcaacaact tgcggctatc cagatggccg ggcaatggca 1740 gggcaggtgc cgtggccctg caggccctca agggctccca ggacagctca gagaatgatc 1800 tggtgcgaag ccccaagtcg gctggcagca gaaccagcag ctccgtcagc agcaccagcg 1860 ccacgatcaa cgggggcctg cgccgggaac aactgatgca ccaggctgtt gaggacctgc 1920 cagagggcgt ggaccctgcc cgcagggagt tctatctctc agactctgac ttccaagata 1980 tctttgggaa atccaaggag gaattctaca gcatggccac gtggaggcag cggcaggaga 2040 aaaagcagct gggcttcttc tgaacccaag ccctctcgac tgcccctatc ccctggaccc 2100 caacatacct acaatgctgg ggaggccctg cttccactcc cctcagaggc ttttggtcat 2160 cctctgcgtg tcagtaaaag caggcagccc ata 2193 <210> SEQ ID NO 10 <211> LENGTH: 2089 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 gcggccgctc cgtgtgccct ggactcgccg cccgcggctc ggaagctgga gagtcagcga 60 cggggcccga ctgcgggacc gagggctgca agaagaagcg aacaaatagt ccccagcgcc 120 tcctctggat gcggtcgcgt ctgtggtcct ggcagccgct gggcgggcca ggccaggtcg 180 ggccgggccg agccgggcac atggacctgg gcctgcgggc tctaattgcg gcgcttatgt 240 tgatgatttt ttttttaatc acagcagccc ccagtttagc ggactgattt actcccggta 300 ttggtaaata tgatcacgtg ggccgcgcga ccaatggtgg aggctgcagc ctgcgaacta 360 gtcggtggct cgggcgccgg cggggagctg ctcggcggcg gacagtgtaa tgttgggtgg 420 gagtgcggga cgcctcaaaa tgtcttccag tggcaccctc agcaactact acgtggactc 480 gcttataggc catgagggcg acgaggtgtt cgcggcgcgc ttcgggccgc cggggccagg 540 cgcgcagggc cggcctgcag gtgtggctga tggcccggcc gccaccgccg ccgagttcgc 600 ctcgtgtagt tttgccccca gatcggccgt gttctctgcc tcgtggtccg cggtgccctc 660 ccagcccccg gcagcggcgg cgatgagcgg cctctaccac ccgtacgttc ccccgccgcc 720 cctggccgcc tctgcctccg agcccggccg ctacgtgcgc tcctggatgg agccgctgcc 780 cggcttcccg ggcggtgcgg gcggtggcgg tggtggtgga ggcggcggtc cgggccgcgg 840 tcccagccct ggccccagcg gcccagccaa cgggcgccac tacgggatta agcctgaaac 900 ccgagcggcc ccggcccccg ccacggccgc ctccaccacc tcctcctcct ccacttcctt 960 atcctcctcc tccaaacgga ctgagtgctc cgtggcccgg gagtcccagg ggagcagcgg 1020 ccccgagttc tcgtgcaact cgttcctgca ggagaaggcg gcagcggcga cggggggaac 1080 cgggcctggg gcagggatcg gggccgcgac tgggacgggc ggctcgtcgg agccctcagc 1140 ttgcagcgac cacccgatcc caggctgttc gctgaaggag gaggagaagc agcattcgca 1200 gccgcagcag cagcaacttg acccaaacaa ccccgccgcg aactggatcc acgctcgctc 1260 cacccggaaa aagcgctgtc cctacaccaa ataccagacg cttgagctgg agaaagaatt 1320 cctcttcaac atgtacctca cccgggaccg gcgctacgag gtggccagga ttctcaacct 1380 aacagagaga caggtcaaaa tctggtttca gaaccgtagg atgaaaatga aaaagatgag 1440 caaggagaaa tgccccaaag gagactgacc cggcgcggtg ctggcgggag cgctcaaggg 1500 cagcggattt gttgttgttg ctgttttcct ttgtgggtgt ttggtgcttg atttccagaa 1560 actctccagc gacttggact tcttcttctt tttttttttc tttttagata gaagtgactg 1620 tgtggttggt ctctgaggta tttgggggac tctgtatttg ctcgtttacg tgttggaaaa 1680 accaagtggc tttggggttt cgccctatcc cactccctct ctttcctgct ccattggttc 1740 cttaagaaat gctatatttt gtgagtgcaa gctggcttgg ggagccctct cttgtgtaaa 1800 tgtcccccat gtttctgaaa agtgctgtag tttagtcccc tcacccccag cactgcccaa 1860 acaggggcca agtgcgcccc aattccaaga atgaaggcag agcgacaaca gtgcggacac 1920 cccggctgct agcccacggt gaagcccggc ggggttgccc accagttgcg aaagccccct 1980 ttcctcaggg agcacgcggg acctcggtgg agatctccag tgaggcttag aggagcccag 2040 ggcctcgggc gggttggggt ttgtcctcag tgcattggac gcgctgctc 2089 <210> SEQ ID NO 11 <211> LENGTH: 8019 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 11 gcggcccggt gcgggtgtcg gggagaccgg gctctctgcc cggcgcggcg cggcgcggct 60 cggcccacga gcgaccaccg acatggagtg ggctcgggcg gccaagtagc cgcttctccg 120 gagcccggtg ccagtgccgc ccgcagcccg ccttccaccc ccggccgcgc cgccggtcag 180 gccctagggt gaagccggga ggaaaatgaa gagttttcac cggaatccgt tgaaaatagg 240 actgactgca aagccttaaa gaaagaagga cctcgggagg agaaacgaaa agccgcctcc 300 gggcaagact tggcgtgctc cgagccgagg ggctgcttca gggacctcgc cccctccctt 360 tcccgctgga gaaattgccg ctgatgcatt atccaagtgg tggttgggag gatttgcagc 420 aacatttttg gttttccctc ccccttctat gcattctgtt tttttcctcc cttttctgtt 480 tttcttcttc ccgggaagtg aattgctgat gcaaatcgga ctttattcat taatgatgca 540 accggattcg tttcaggatt acgttgcacg agttgaattt tgaatgaagg agaagagttt 600 tttttttttt ttttaaagaa gtgttgactc tctagttcgt tgtactttta attattattt 660 tatttaaata tacgacttaa ttgtattctt ttaaaaatgc attaagtata tattttatgg 720 taatttaccc tcaaaatata tgtatatggg tgaaattgaa gacgcttcag ttaagtgagg 780 ttactggtgt gttggatgtt taattcagca ccagcattgc atgacagttg tttgaataac 840 aagtggttta tttttaaaac catacctttt aaaatttagg ttcagataat agtaaaagtc 900 atcataataa tttaaaggaa aaccagcaga aatcgaagca aacatgtctg gagaagtgcg 960 tttgaggcag ttggagcagt ttattttgga cgggcccgct cagaccaatg ggcagtgctt 1020 cagtgtggag acattactgg atatactcat ctgcctttat gatgaatgca ataattctcc 1080 attgagaaga gagaagaaca ttctcgaata cctagaatgg gctaaaccat ttacttctaa 1140 agtgaaacaa atgcgattac atagagaaga ctttgaaata ttaaaggtga ttggtcgagg 1200 agcttttggg gaggttgctg tagtaaaact aaaaaatgca gataaagtgt ttgccatgaa 1260 aatattgaat aaatgggaaa tgctgaaaag agctgagaca gcatgttttc gtgaagaaag 1320 ggatgtatta gtgaatggag acaataaatg gattacaacc ttgcactatg ctttccagga 1380 tgacaataac ttatacctgg ttatggatta ttatgttggt ggggatttgc ttactctact 1440 cagcaaattt gaagatagat tgcctgaaga tatggctaga ttttacttgg ctgagatggt 1500 gatagcaatt gactcagttc atcagctaca ttatgtacac agagacatta aacctgacaa 1560 tatactgatg gatatgaatg gacatattcg gttagcagat tttggttctt gtctgaagct 1620 gatggaagat ggaacggttc agtcctcagt ggctgtagga actccagatt atatctctcc 1680 tgaaatcctt caagccatgg aagatggaaa agggagatat ggacctgaat gtgactggtg 1740 gtctttgggg gtctgtatgt atgaaatgct ttacggagaa acaccatttt atgcagaatc 1800 gctggtggag acatacggaa aaatcatgaa ccacaaagag aggtttcagt ttccagccca 1860 agtgactgat gtgtctgaaa atgctaagga tcttattcga aggctcattt gtagcagaga 1920 acatcgactt ggtcaaaatg gaatagaaga ctttaagaaa cacccatttt tcagtggaat 1980 tgattgggat aatattcgga actgtgaagc accttatatt ccagaagtta gtagcccaac 2040 agatacatcg aattttgatg tagatgatga ttgtttaaaa aattctgaaa cgatgccccc 2100 accaacacat actgcatttt ctggccacca tctgccattt gttggtttta catatactag 2160 tagctgtgta ctttctgatc ggagctgttt aagagttacg gctggtccca cctcactgga 2220 tcttgatgtt aatgttcaga ggactctaga caacaactta gcaactgaag cttatgaaag 2280 aagaattaag cgccttgagc aagaaaaact tgaactcagt agaaaacttc aagagtcaac 2340 acagactgtc caagctctgc agtattcaac tgttgatggt ccactaacag caagcaaaga 2400 tttagaaata aaaaacttaa aagaagaaat tgaaaaacta agaaaacaag taacagaatc 2460 aagtcatttg gaacagcaac ttgaagaagc taatgctgtg aggcaagaac tagatgatgc 2520 ttttagacaa atcaaggctt atgaaaaaca aatcaaaacg ttacaacaag aaagagaaga 2580 tctaaataag gaactagtcc aggctagtga gcgattaaaa aaccaatcca aagagctgaa 2640 agacgcacac tgtcagagga aactggccat gcaggaattc atggagatca atgagcggct 2700 aacagaattg cacacccaaa aacagaaact tgctcgccat gtccgagata aggaagaaga 2760 ggtggacctg gtgatgcaaa aagttgaaag cttaaggcaa gaactgcgca gaacagaaag 2820 agccaaaaaa gagctggaag ttcatacaga agctctagct gctgaagcat ctaaagacag 2880 gaagctacgt gaacagagtg agcactattc taagcaactg gaaaatgaat tggagggact 2940 gaagcaaaaa caaattagtt actcaccagg agtatgcagc atagaacatc agcaagagat 3000 aaccaaacta aagactgatt tggaaaagaa aagtatcttt tatgaagaag aattatctaa 3060 aagagaagga atacatgcaa atgaaataaa aaatcttaag aaagaactgc atgattcaga 3120 aggtcagcaa cttgctctca acaaagaaat tatgatttta aaagacaaat tggaaaaaac 3180 cagaagagaa agtcaaagtg aaagggagga atttgaaagt gagttcaaac aacaatatga 3240 acgagaaaaa gtgttgttaa ctgaagaaaa taaaaagctg acgagtgaac ttgataagct 3300 tactactttg tatgagaact taagtataca caaccagcag ttagaagaag aggttaaaga 3360 tctagcagac aagaaagaat cagttgcaca ttgggaagcc caaatcacag aaataattca 3420 gtgggtcagc gatgaaaagg atgcacgagg gtatcttcag gccttagctt ctaaaatgac 3480 tgaagaattg gaggcattaa gaaattccag cttgggtaca cgagcaacag atatgccctg 3540 gaaaatgcgt cgttttgcga aactggatat gtcagctaga ctggagttgc agtcggctct 3600 ggatgcagaa ataagagcca aacaggccat ccaagaagag ttgaataaag ttaaagcatc 3660 taatatcata acagaatgta aactaaaaga ttcagagaag aagaacttgg aactactctc 3720 agaaatcgaa cagctgataa aggacactga agagcttaga tctgaaaagg gtatagagca 3780 ccaagactca cagcattctt tcttggcatt tttgaatacg cctaccgatg ctctggatca 3840 atttgaaact gtagactcca ctccactttc agttcacaca ccaaccttaa ggaaaaaagg 3900 atgtcctggt tcaactggct ttccacctaa gcgcaagact caccagtttt ttgtaaaatc 3960 ttttactact cctaccaagt gtcatcagtg tacctccttg atggtgggtt taataagaca 4020 gggctgttca tgtgaagtgt gtggattctc atgccatata acttgtgtaa acaaagctcc 4080 aaccacttgt ccagttcctc ctgaacagac aaaaggtccc ctgggtatag atcctcagaa 4140 aggaatagga acagcatatg aaggtcatgt caggattcct aagccagctg gagtgaagaa 4200 agggtggcag agagcactgg ctatagtgtg tgacttcaaa ctctttctgt acgatattgc 4260 tgaaggaaaa gcatctcagc ccagtgttgt cattagtcaa gtgattgaca tgagggatga 4320 agaattttct gtgagttcag tcttggcttc tgatgttatc catgcaagtc ggaaagatat 4380 accctgtata tttagggtca cagcttccca gctctcagca tctaataaca aatgttcaat 4440 cctgatgcta gcagacactg agaatgagaa gaataagtgg gtgggagtgc tgagtgaatt 4500 gcacaagatt ttgaagaaaa acaaattcag agaccgctca gtctatgttc ccaaagaggc 4560 ttatgacagc actctacccc tcattaaaac aacccaggca gccgcaatca tagatcatga 4620 aagaattgct ttgggaaacg aagaagggtt atttgttgta catgtcacca aagatgaaat 4680 tattagagtt ggtgacaata agaagattca tcagattgaa ctcattccaa atgatcagct 4740 tgttgctgtg atctcaggac gaaatcgtca tgtacgactt tttcctatgt cagcattgga 4800 tgggcgagag accgattttt acaagctgtc agaaactaaa gggtgtcaaa ccgtaacttc 4860 tggaaaggtg cgccatggag ctctcacatg cctgtgtgtg gctatgaaaa ggcaggtcct 4920 ctgttatgaa ctatttcaga gcaagacccg tcacagaaaa tttaaagaaa ttcaagtccc 4980 atataatgtc cagtggatgg caatcttcag tgaacaactc tgtgtgggat tccagtcagg 5040 atttctaaga taccccttga atggagaagg aaatccatac agtatgctcc attcaaatga 5100 ccatacacta tcatttattg cacatcaacc aatggatgct atctgcgcag ttgagatctc 5160 cagtaaagaa tatctgctgt gttttaacag cattgggata tacactgact gccagggccg 5220 aagatctaga caacaggaat tgatgtggcc agcaaatcct tcctcttgtt gttacaatgc 5280 accatatctc tcggtgtaca gtgaaaatgc agttgatatc tttgatgtga actccatgga 5340 atggattcag actcttcctc tcaaaaaggt tcgaccctta aacaatgaag gatcattaaa 5400 tcttttaggg ttggagacca ttagattaat atatttcaaa aataagatgg cagaagggga 5460 cgaactggta gtacctgaaa catcagataa tagtcggaaa caaatggtta gaaacattaa 5520 caataagcgg cgttattcct tcagagtccc agaagaggaa aggatgcagc agaggaggga 5580 aatgctacga gatccagaaa tgagaaataa attaatttct aatccaacta attttaatca 5640 catagcacac atgggtcctg gagatggaat acagatcctg aaagatctgc ccatgaaccc 5700 tcggcctcag gaaagtcgga cagtattcag tggctcagtc agtattccat ctatcaccaa 5760 atcccgccct gagccaggcc gctccatgag tgctagcagt ggcttgtcag caaggtcatc 5820 cgcacagaat ggcagcgcat taaagaggga attctctgga ggaagctaca gtgccaagcg 5880 gcagcccatg ccctccccgt cagagggctc tttgtcctct ggaggcatgg accaaggaag 5940 tgatgcccca gcgagggact ttgacggaga ggactctgac tctccgaggc attccacagc 6000 ttccaacagt tccaacctaa gcagcccccc aagcccagct tcaccccgaa aaaccaagag 6060 cctctccctg gagagcactg accgcgggag ctgggacccg tgagctgcct cagcactggg 6120 acctctcgct ctccgctccc tgccactcgc ctcctctcac tttcatctct tccctccacc 6180 tcgcctgctc ggcctgaaag ccaccagggg ctggcagcag tagcaggaca gggattcagg 6240 agttctgacg acacgactct cagatccacg cccccagcct aacagcaaca acaaagacag 6300 actttccgta gcagcttaga ttaacgttga tttcattcca tgcacttaga gttgctttca 6360 gtaacatttt acccctactc ccaaaggtag cttaaataga cagattacac aaatgtaagt 6420 gataagaata agattagaca gattttgctt tcacagtaga gtctcattat agtcctaaaa 6480 tagctcatgg gcttctccgc atccagaagg gagaattggt ccctggagtg gctcactaag 6540 ctcttaatca gcaaacgcag tgagtatcaa cctgattgtt gccaggaaat ccttatgaat 6600 taaaacaatg catattttac tacagtacag agtttaaatg aatacataaa tgtagaagta 6660 ctgaatgtat atatttaaaa ggagcctctt gtattcaaca aaagatggat gcatatataa 6720 gagagatgat ttaatttaaa gaaatatgtt gtttcttgtc tgtaatgtaa tgtaaagggt 6780 ggaaaggcct caagctcaca tttgtagaga gagagcgaga gaaatcagag ttccctttat 6840 tgccctgtcc tcaaactggt cataggctct agtcacctgg ggagctgtag aaaacacttg 6900 cagagccagg ttttgctggt ttggggcatg ccctgggcac cagagcttta acatttgaag 6960 ccacttcagc agcagcagca aaaggcgaac tcatctctac ccaagatgtt tcttttccta 7020 gtggtggaat ttgaacactt ctcacttttt attgtatttt atcttccgca gataaatgta 7080 gaaatacacg attctgtcac ctctgatccc ttccatctga aaggttacaa ggagtgttgt 7140 agcttctgaa ggtgcagaaa acaatttcta aaaatgcttt tattcctggg ctaatcctgt 7200 ccctccctaa gtcacagcga ggtgtctgtc ccagggctgg agatgcttcc caaggaggag 7260 tctgttttgt tgagagtggg cgtgggcttc ttcacataag cctggggaag gaagaaaaaa 7320 cggctttcat taccaaataa tgtaaaacct caaaagcaag ggcttcaaca gccttaacca 7380 aatattattc cccatagcca gtggaaaatg gatgtgacaa ccccagtgcg caggccagag 7440 tgagtgagcc cagcacggcg ctccgactgg cttcctctct caggtgctgg attgtggggt 7500 tagtggcatt tccagctgga ttcctcctgt tgtagttgcc ataaggaaat gagatgcaga 7560 atcagaagga tctatttcta cagaatcatt tcaccagtta agcacatgag tagagaaaga 7620 gataaaaata aaagtatctc atgaaggaaa gagattttgc ctctctttta cttttcacct 7680 aagtttctct gagaaataga gacaggattc tctctttaaa attcagtgaa aatgaagaaa 7740 gttttcctgc agttgctaac ctgagttgca gtgtttaagg ccatcatttc actgctgctg 7800 tctgtgactc cacgtctgtg tcactgaggt gacctgcgtg tcactgaggt ggccaccatg 7860 ctggcctgcg gcatgtgcag ggagctgagg ctgtttccag gtgatgctgc tgtgtggaga 7920 aggttctgag atgcagtgag ggaagaaagg atcctgctgg ggattccatt gtaagcacct 7980 ataatcggga attttcatgt aacagctttg acatttaaa 8019 <210> SEQ ID NO 12 <211> LENGTH: 7776 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 gcggcccggt gcgggtgtcg gggagaccgg gctctctgcc cggcgcggcg cggcgcggct 60 cggcccacga gcgaccaccg acatggagtg ggctcgggcg gccaagtagc cgcttctccg 120 gagcccggtg ccagtgccgc ccgcagcccg ccttccaccc ccggccgcgc cgccggtcag 180 gccctagggt gaagccggga ggaaaatgaa gagttttcac cggaatccgt tgaaaatagg 240 actgactgca aagccttaaa gaaagaagga cctcgggagg agaaacgaaa agccgcctcc 300 gggcaagact tggcgtgctc cgagccgagg ggctgcttca gggacctcgc cccctccctt 360 tcccgctgga gaaattgccg ctgatgcatt atccaagtgg tggttgggag gatttgcagc 420 aacatttttg gttttccctc ccccttctat gcattctgtt tttttcctcc cttttctgtt 480 tttcttcttc ccgggaagtg aattgctgat gcaaatcgga ctttattcat taatgatgca 540 accggattcg tttcaggatt acgttgcacg agttgaattt tgaatgaagg agaagagttt 600 tttttttttt ttttaaagaa gtgttgactc tctagttcgt tgtactttta attattattt 660 tatttaaata tacgacttaa ttgtattctt ttaaaaatgc attaagtata tattttatgg 720 taatttaccc tcaaaatata tgtatatggg tgaaattgaa gacgcttcag ttaagtgagg 780 ttactggtgt gttggatgtt taattcagca ccagcattgc atgacagttg tttgaataac 840 aagtggttta tttttaaaac catacctttt aaaatttagg ttcagataat agtaaaagtc 900 atcataataa tttaaaggaa aaccagcaga aatcgaagca aacatgtctg gagaagtgcg 960 tttgaggcag ttggagcagt ttattttgga cgggcccgct cagaccaatg ggcagtgctt 1020 cagtgtggag acattactgg atatactcat ctgcctttat gatgaatgca ataattctcc 1080 attgagaaga gagaagaaca ttctcgaata cctagaatgg gctaaaccat ttacttctaa 1140 agtgaaacaa atgcgattac atagagaaga ctttgaaata ttaaaggtga ttggtcgagg 1200 agcttttggg gaggttgctg tagtaaaact aaaaaatgca gataaagtgt ttgccatgaa 1260 aatattgaat aaatgggaaa tgctgaaaag agctgagaca gcatgttttc gtgaagaaag 1320 ggatgtatta gtgaatggag acaataaatg gattacaacc ttgcactatg ctttccagga 1380 tgacaataac ttatacctgg ttatggatta ttatgttggt ggggatttgc ttactctact 1440 cagcaaattt gaagatagat tgcctgaaga tatggctaga ttttacttgg ctgagatggt 1500 gatagcaatt gactcagttc atcagctaca ttatgtacac agagacatta aacctgacaa 1560 tatactgatg gatatgaatg gacatattcg gttagcagat tttggttctt gtctgaagct 1620 gatggaagat ggaacggttc agtcctcagt ggctgtagga actccagatt atatctctcc 1680 tgaaatcctt caagccatgg aagatggaaa agggagatat ggacctgaat gtgactggtg 1740 gtctttgggg gtctgtatgt atgaaatgct ttacggagaa acaccatttt atgcagaatc 1800 gctggtggag acatacggaa aaatcatgaa ccacaaagag aggtttcagt ttccagccca 1860 agtgactgat gtgtctgaaa atgctaagga tcttattcga aggctcattt gtagcagaga 1920 acatcgactt ggtcaaaatg gaatagaaga ctttaagaaa cacccatttt tcagtggaat 1980 tgattgggat aatattcgga actgtgaagc accttatatt ccagaagtta gtagcccaac 2040 agatacatcg aattttgatg tagatgatga ttgtttaaaa aattctgaaa cgatgccccc 2100 accaacacat actgcatttt ctggccacca tctgccattt gttggtttta catatactag 2160 tagctgtgta ctttctgatc ggagctgttt aagagttacg gctggtccca cctcactgga 2220 tcttgatgtt aatgttcaga ggactctaga caacaactta gcaactgaag cttatgaaag 2280 aagaattaag cgccttgagc aagaaaaact tgaactcagt agaaaacttc aagagtcaac 2340 acagactgtc caagctctgc agtattcaac tgttgatggt ccactaacag caagcaaaga 2400 tttagaaata aaaaacttaa aagaagaaat tgaaaaacta agaaaacaag taacagaatc 2460 aagtcatttg gaacagcaac ttgaagaagc taatgctgtg aggcaagaac tagatgatgc 2520 ttttagacaa atcaaggctt atgaaaaaca aatcaaaacg ttacaacaag aaagagaaga 2580 tctaaataag ctggaagttc atacagaagc tctagctgct gaagcatcta aagacaggaa 2640 gctacgtgaa cagagtgagc actattctaa gcaactggaa aatgaattgg agggactgaa 2700 gcaaaaacaa attagttact caccaggagt atgcagcata gaacatcagc aagagataac 2760 caaactaaag actgatttgg aaaagaaaag tatcttttat gaagaagaat tatctaaaag 2820 agaaggaata catgcaaatg aaataaaaaa tcttaagaaa gaactgcatg attcagaagg 2880 tcagcaactt gctctcaaca aagaaattat gattttaaaa gacaaattgg aaaaaaccag 2940 aagagaaagt caaagtgaaa gggaggaatt tgaaagtgag ttcaaacaac aatatgaacg 3000 agaaaaagtg ttgttaactg aagaaaataa aaagctgacg agtgaacttg ataagcttac 3060 tactttgtat gagaacttaa gtatacacaa ccagcagtta gaagaagagg ttaaagatct 3120 agcagacaag aaagaatcag ttgcacattg ggaagcccaa atcacagaaa taattcagtg 3180 ggtcagcgat gaaaaggatg cacgagggta tcttcaggcc ttagcttcta aaatgactga 3240 agaattggag gcattaagaa attccagctt gggtacacga gcaacagata tgccctggaa 3300 aatgcgtcgt tttgcgaaac tggatatgtc agctagactg gagttgcagt cggctctgga 3360 tgcagaaata agagccaaac aggccatcca agaagagttg aataaagtta aagcatctaa 3420 tatcataaca gaatgtaaac taaaagattc agagaagaag aacttggaac tactctcaga 3480 aatcgaacag ctgataaagg acactgaaga gcttagatct gaaaagggta tagagcacca 3540 agactcacag cattctttct tggcattttt gaatacgcct accgatgctc tggatcaatt 3600 tgaaactgta gactccactc cactttcagt tcacacacca accttaagga aaaaaggatg 3660 tcctggttca actggctttc cacctaagcg caagactcac cagttttttg taaaatcttt 3720 tactactcct accaagtgtc atcagtgtac ctccttgatg gtgggtttaa taagacaggg 3780 ctgttcatgt gaagtgtgtg gattctcatg ccatataact tgtgtaaaca aagctccaac 3840 cacttgtcca gttcctcctg aacagacaaa aggtcccctg ggtatagatc ctcagaaagg 3900 aataggaaca gcatatgaag gtcatgtcag gattcctaag ccagctggag tgaagaaagg 3960 gtggcagaga gcactggcta tagtgtgtga cttcaaactc tttctgtacg atattgctga 4020 aggaaaagca tctcagccca gtgttgtcat tagtcaagtg attgacatga gggatgaaga 4080 attttctgtg agttcagtct tggcttctga tgttatccat gcaagtcgga aagatatacc 4140 ctgtatattt agggtcacag cttcccagct ctcagcatct aataacaaat gttcaatcct 4200 gatgctagca gacactgaga atgagaagaa taagtgggtg ggagtgctga gtgaattgca 4260 caagattttg aagaaaaaca aattcagaga ccgctcagtc tatgttccca aagaggctta 4320 tgacagcact ctacccctca ttaaaacaac ccaggcagcc gcaatcatag atcatgaaag 4380 aattgctttg ggaaacgaag aagggttatt tgttgtacat gtcaccaaag atgaaattat 4440 tagagttggt gacaataaga agattcatca gattgaactc attccaaatg atcagcttgt 4500 tgctgtgatc tcaggacgaa atcgtcatgt acgacttttt cctatgtcag cattggatgg 4560 gcgagagacc gatttttaca agctgtcaga aactaaaggg tgtcaaaccg taacttctgg 4620 aaaggtgcgc catggagctc tcacatgcct gtgtgtggct atgaaaaggc aggtcctctg 4680 ttatgaacta tttcagagca agacccgtca cagaaaattt aaagaaattc aagtcccata 4740 taatgtccag tggatggcaa tcttcagtga acaactctgt gtgggattcc agtcaggatt 4800 tctaagatac cccttgaatg gagaaggaaa tccatacagt atgctccatt caaatgacca 4860 tacactatca tttattgcac atcaaccaat ggatgctatc tgcgcagttg agatctccag 4920 taaagaatat ctgctgtgtt ttaacagcat tgggatatac actgactgcc agggccgaag 4980 atctagacaa caggaattga tgtggccagc aaatccttcc tcttgttgtt acaatgcacc 5040 atatctctcg gtgtacagtg aaaatgcagt tgatatcttt gatgtgaact ccatggaatg 5100 gattcagact cttcctctca aaaaggttcg acccttaaac aatgaaggat cattaaatct 5160 tttagggttg gagaccatta gattaatata tttcaaaaat aagatggcag aaggggacga 5220 actggtagta cctgaaacat cagataatag tcggaaacaa atggttagaa acattaacaa 5280 taagcggcgt tattccttca gagtcccaga agaggaaagg atgcagcaga ggagggaaat 5340 gctacgagat ccagaaatga gaaataaatt aatttctaat ccaactaatt ttaatcacat 5400 agcacacatg ggtcctggag atggaataca gatcctgaaa gatctgccca tgaaccctcg 5460 gcctcaggaa agtcggacag tattcagtgg ctcagtcagt attccatcta tcaccaaatc 5520 ccgccctgag ccaggccgct ccatgagtgc tagcagtggc ttgtcagcaa ggtcatccgc 5580 acagaatggc agcgcattaa agagggaatt ctctggagga agctacagtg ccaagcggca 5640 gcccatgccc tccccgtcag agggctcttt gtcctctgga ggcatggacc aaggaagtga 5700 tgccccagcg agggactttg acggagagga ctctgactct ccgaggcatt ccacagcttc 5760 caacagttcc aacctaagca gccccccaag cccagcttca ccccgaaaaa ccaagagcct 5820 ctccctggag agcactgacc gcgggagctg ggacccgtga gctgcctcag cactgggacc 5880 tctcgctctc cgctccctgc cactcgcctc ctctcacttt catctcttcc ctccacctcg 5940 cctgctcggc ctgaaagcca ccaggggctg gcagcagtag caggacaggg attcaggagt 6000 tctgacgaca cgactctcag atccacgccc ccagcctaac agcaacaaca aagacagact 6060 ttccgtagca gcttagatta acgttgattt cattccatgc acttagagtt gctttcagta 6120 acattttacc cctactccca aaggtagctt aaatagacag attacacaaa tgtaagtgat 6180 aagaataaga ttagacagat tttgctttca cagtagagtc tcattatagt cctaaaatag 6240 ctcatgggct tctccgcatc cagaagggag aattggtccc tggagtggct cactaagctc 6300 ttaatcagca aacgcagtga gtatcaacct gattgttgcc aggaaatcct tatgaattaa 6360 aacaatgcat attttactac agtacagagt ttaaatgaat acataaatgt agaagtactg 6420 aatgtatata tttaaaagga gcctcttgta ttcaacaaaa gatggatgca tatataagag 6480 agatgattta atttaaagaa atatgttgtt tcttgtctgt aatgtaatgt aaagggtgga 6540 aaggcctcaa gctcacattt gtagagagag agcgagagaa atcagagttc cctttattgc 6600 cctgtcctca aactggtcat aggctctagt cacctgggga gctgtagaaa acacttgcag 6660 agccaggttt tgctggtttg gggcatgccc tgggcaccag agctttaaca tttgaagcca 6720 cttcagcagc agcagcaaaa ggcgaactca tctctaccca agatgtttct tttcctagtg 6780 gtggaatttg aacacttctc actttttatt gtattttatc ttccgcagat aaatgtagaa 6840 atacacgatt ctgtcacctc tgatcccttc catctgaaag gttacaagga gtgttgtagc 6900 ttctgaaggt gcagaaaaca atttctaaaa atgcttttat tcctgggcta atcctgtccc 6960 tccctaagtc acagcgaggt gtctgtccca gggctggaga tgcttcccaa ggaggagtct 7020 gttttgttga gagtgggcgt gggcttcttc acataagcct ggggaaggaa gaaaaaacgg 7080 ctttcattac caaataatgt aaaacctcaa aagcaagggc ttcaacagcc ttaaccaaat 7140 attattcccc atagccagtg gaaaatggat gtgacaaccc cagtgcgcag gccagagtga 7200 gtgagcccag cacggcgctc cgactggctt cctctctcag gtgctggatt gtggggttag 7260 tggcatttcc agctggattc ctcctgttgt agttgccata aggaaatgag atgcagaatc 7320 agaaggatct atttctacag aatcatttca ccagttaagc acatgagtag agaaagagat 7380 aaaaataaaa gtatctcatg aaggaaagag attttgcctc tcttttactt ttcacctaag 7440 tttctctgag aaatagagac aggattctct ctttaaaatt cagtgaaaat gaagaaagtt 7500 ttcctgcagt tgctaacctg agttgcagtg tttaaggcca tcatttcact gctgctgtct 7560 gtgactccac gtctgtgtca ctgaggtgac ctgcgtgtca ctgaggtggc caccatgctg 7620 gcctgcggca tgtgcaggga gctgaggctg tttccaggtg atgctgctgt gtggagaagg 7680 ttctgagatg cagtgaggga agaaaggatc ctgctgggga ttccattgta agcacctata 7740 atcgggaatt ttcatgtaac agctttgaca tttaaa 7776 <210> SEQ ID NO 13 <211> LENGTH: 2757 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 13 attgtaaact agtttttggt ttgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 60 aaaaaaaaaa aaggtctttt gtaactgact tctttcactt agcaaatgga agggtttttg 120 atggaatctt agctcagatg tcgccctagg cttggccttc tggaactcac tgttctcttg 180 cttccttcca ccctgcctcc ctacccgctt tgctacaaga agacagaatg tagaaacccc 240 cagttgactt tttgagtaga aatgagccat gttctattta gtggtagaat gtttgctggg 300 ttagcccagg acttcagatg gagtgcttcc tcctttttaa taccttgtga ctgctgtgtt 360 ggcaagcaga gggttaaatg ctgcaggagg acatgggaga gtttttgctt tgagggtcca 420 ctggagcaag agaagcttga gagtctgtct ctgagatccc agaacagaca tgaagatatg 480 gtaccgattc ccttggtgct aaaaggaact ccaggggaat ttcaggaaac ccctcctttt 540 ctcgtcttta ttctcacccc gtccccccgc cacctctctc cccaagttca cactcaggag 600 ggaggaatct tttacctttt ccgttctggg cagcagcctg tagggaatgt tatcagtgtt 660 gggactgggc acgggaccaa gccttcctgg tgcctggact gcaacctagc tgagagctga 720 catggcaggg cgagttgtgt gtgagttggc tgcccctagg ctcataggcc tagcacaata 780 gagaccctgt caatggaggg acactatcag gcaggtcact atcaatgtga cagacactat 840 caggcaggtc acattggtgc agatccttgg aggactcccc cccacccccc atgagtggat 900 tcctccaggt caggggctgg ctgggactgt ggatgctgga gtaagtggaa ttgtgggtgc 960 actctgcttc agcagtactc tccaaggaga atgattgttt taataaatta ctgttttaat 1020 aagggaggtg gaagagcttt ttaatcactt gctttttaaa aatttttaat tttattttaa 1080 ttaattagtt tatttatttt ttgagacgga gtcttgctct gtcgcccagg ctggagtgca 1140 gtggcacgat ctcggctcac tgcacctctg cctcctggat tcacaccatt ctcctgcctc 1200 agcctccaga gtagctggga ctacaggcac ccgccaccac gcccgactaa ttttttgtat 1260 ttttagcaga gacggggttt caccgtgtta gccaggatgg tgtagatctc ctgaccttgt 1320 gatcctcccg cctcagcctt ccaaagggag ggattactgg cgtgagtcac cgcgcctggc 1380 ctttattttt tatttctttt gagatggagt tttgctctgt cacccaggct ggagtaccgg 1440 tggtgggatc tcgcctcact gcaacttgcg cctcccgggt tcaagcgatt ctccagcctc 1500 agcctcctga gtagctggga ttacaggcgt gtgccaccgc ctccagctaa tttttgtatt 1560 tttagtagag accgggcttc accatgttgg ccaggctggt ctcgaactcc tgacctcagg 1620 tgagcgtcct gccttggcct cccaaagtgc tgggattaca ggcgtgagcc actacaccca 1680 gccaatcagt tgcttttaaa ctacttaaat aaaaagagcc aacccaaaat cttgtgcatg 1740 cttgggaaac tggcagtgga atatgagaag tttttatttg tggtgcacac aggtgactcg 1800 ggctgttgtg tattggttct tgcctcgatc tgtagcaagc aatctgttgt ttcttgcctg 1860 ccttttggga agaaatgaaa aaagaagcag cacgagtctc catacatcat gattgtgatg 1920 gcactgggcc tgagaccttt tctgctgtcc aggtaaaaat gtgaagacca tggttttgag 1980 gtttcttaat aaattcaggt gttaagtgcc aagtgatgct cccagcccct gagctagagc 2040 aactatgctg ttcatgtccc caggaatgga agtggaccct agttaggtgc tggtggccag 2100 ccatgtgtac ctagggcagg gccaggtcct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 2160 gtgtgtgtgt gagagagaga gagagagaga gagagagaca gagagagaga tagagagaaa 2220 cataaaggtg atcggcactc agacatcctg tgtggtccac ctcacttctc aagcaggtgt 2280 ctttccagtc tacaactcgt tgaccacagg tggaattcat aagctctgtt ccctgtcctg 2340 cttgggtcct ccagagaaag aaatgttgaa ttatcatctt ggtgatggtc aactctgaaa 2400 gcctaaattt tcatgatcac caaagtgttt ggatttaaaa gggtggctca ctccgtaatt 2460 ccggcacttt gggaggctga ggcagaagga tcacttgagc ccagaagttt cagactaggc 2520 tgggcaacaa agcaagaccc ggtctctccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2580 tcaaaaaaat tagctggggg tggtggtgtg ctcctatagc tccagctact caggaggctg 2640 aggcgggagg atcgcttgag cccaggggtt tgcggctgca gtgagctgtg attgcaccac 2700 tgcactccag cctgggcgac tgtgagaccc cgtctttaag aaaaaaaaaa aaaaaaa 2757 <210> SEQ ID NO 14 <211> LENGTH: 2444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 14 ggtttttttt ttttaccccc cttttttatt tattattttt ttgcacattg agcggatcct 60 tgggaacgag agaaaaaaga aacccaaact cacgcgtgca gaagatctcc ccccccttcc 120 cctcccctcc tccctctttt cccctcccca ggagaaaaag acccccaagc agaaaaaagt 180 tcaccttgga ctcgtctttt tcttgcaata ttttttgggg gggcaaaact ttgagggggt 240 gatttttttt ggcttttctt cctccttcat ttttcttcca aaattgctgc tggtgggtga 300 aaaaaaaatg ccgcagctga acggcggtgg aggggatgac ctaggcgcca acgacgaact 360 gatttccttc aaagacgagg gcgaacagga ggagaagagc tccgaaaact cctcggcaga 420 gagggattta gctgatgtca aatcgtctct agtcaatgaa tcagaaacga atcaaaacag 480 ctcctccgat tccgaggcgg aaagacggcc tccgcctcgc tccgaaagtt tccgagacaa 540 atcccgggaa agtttggaag aagcggccaa gaggcaagat ggagggctct ttaaggggcc 600 accgtatccc ggctacccct tcatcatgat ccccgacctg acgagcccct acctccccaa 660 cggatcgctc tcgcccaccg cccgaaccta tctccagatg aaatggccac tgcttgatgt 720 ccaggcaggg agcctccaga gtagacaagc cctcaaggat gcccggtccc catcaccggc 780 acacattgtc tctaacaaag tgccagtggt gcagcaccct caccatgtcc accccctcac 840 gcctcttatc acgtacagca atgaacactt cacgccggga aacccacctc cacacttacc 900 agccgacgta gaccccaaaa caggaatccc acggcctccg caccctccag atatatcccc 960 gtattaccca ctatcgcctg gcaccgtagg acaaatcccc catccgctag gatggttagt 1020 accacagcaa ggtcaaccag tgtacccaat cacgacagga ggattcagac acccctaccc 1080 cacagctctg accgtcaatg cttccgtgtc caggttccct ccccatatgg tcccaccaca 1140 tcatacgcta cacacgacgg gcattccgca tccggccata gtcacaccaa cagtcaaaca 1200 ggaatcgtcc cagagtgatg tcggctcact ccatagttca aagcatcagg actccaaaaa 1260 ggaagaagaa aagaagaagc cccacataaa gaaacctctt aatgcattca tgttgtatat 1320 gaaggaaatg agagcaaagg tcgtagctga gtgcacgttg aaagaaagcg cggccatcaa 1380 ccagatcctt gggcggaggt ggcatgcact gtccagagaa gagcaagcga aatactacga 1440 gctggcccgg aaggagcgac agcttcatat gcaactgtac cccggctggt ccgcgcggga 1500 taactatgga aagaagaaga agaggaaaag ggacaagcag ccgggagaga ccaatgaaca 1560 cagcgaatgt ttcctaaatc cttgcctttc acttcctccg attacagacc tcagcgctcc 1620 taagaaatgc cgagcgcgct ttggccttga tcaacagaat aactggtgcg gcccttgcag 1680 gagaaaaaaa aagtgcgttc gctacataca aggtgaaggc agctgcctca gcccaccctc 1740 ttcagatgga agcttactag attcgcctcc cccctccccg aacctgctag gctcccctcc 1800 ccgagacgcc aagtcacaga ctgagcagac ccagcctctg tcgctgtccc tgaagcccga 1860 ccccctggcc cacctgtcca tgatgcctcc gccacccgcc ctcctgctcg ctgaggccac 1920 ccacaaggcc tccgccctct gtcccaacgg ggccctggac ctgcccccag ccgctttgca 1980 gcctgccgcc ccctcctcat caattgcaca gccgtcgact tcttggttac attcccacag 2040 ctccctggcc gggacccagc cccagccgct gtcgctcgtc accaagtctt tagaatagct 2100 ttagcgtcgt gaaccccgct gctttgttta tggttttgtt tcacttttct taatttgccc 2160 cccaccccca ccttgaaagg ttttgttttg tactctctta attttgtgcc atgtggctac 2220 attagttgat gtttatcgag ttcattggtc aatatttgac ccattcttat ttcaatttct 2280 ccttttaaat atgtagatga gagaagaacc tcatgattgg taccaaaatt tttatcaaca 2340 gctgtttaaa gtctttgtag cgtttaaaaa atatatatat atacataact gttatgtagt 2400 tcggatagct tagttttaaa agactgatta aaaaacaaaa aaaa 2444 <210> SEQ ID NO 15 <211> LENGTH: 1573 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 15 cttccccggt gcagacaccc ggcgaagccc acccggtttt cccagcggca tttccgatga 60 cagcttcggg gctacgtgtc ctgtgctgtc ggagacgcac aggaagcaaa gtttgtgaga 120 agccttgggg gcgactttgc cttgggcacc cgcatttgtg cgtctgcgag gtgcctcggt 180 gtgcgcggag ctagtttccc agtttcccgg gcccctccct tctccgagcc cctctagcga 240 tttgtttagg aaaagtgatg acatgaacta gtagtggaga atcgcagcgc cgctccccgc 300 cctggggagg gaggggagcc ccggagagcc tgccggtggg agctggaagc aggctcccgg 360 ctgagcgccc cagcccgaaa ggcagggtct gggtgcggga agagggctcg gagctgcctt 420 cctgctgcct tggggccgcc cagatgaggg aacagcccga tttgcctggt tctgattctc 480 caggctgtcg tggttgtgga atgcaaacgc cagcacataa tggaaacagg acctgaagac 540 ccttccagca tgccagagga aagttccccc aggcggaccc cgcagagcat tccctaccag 600 gacctccctc acctggtcaa tgcagacgga cagtacctct tctgcaggta ctggaaaccc 660 acaggcacac ccaaggccct catctttgtg tcccatggag ccggagagca cagtggccgc 720 tatgaagagc tggctcggat gctgatgggg ctggacctgc tggtgttcgc ccacgaccat 780 gttggccacg gacagagcga aggggagagg atggtagtgt ctgacttcca cgttttcgtc 840 agggatgtgt tgcagcatgt ggattccatg cagaaagact accctgggct tcctgtcttc 900 cttctgggcc actccatggg aggcgccatc gccatcctca cggccgcaga gaggccgggc 960 cacttcgccg gcatggtact catttcgcct ctggttcttg ccaatcctga atctgcaaca 1020 actttcaagg tccttgctgc gaaagtgctc aaccttgtgc tgccaaactt gtccctcggg 1080 cccatcgact ccagcgtgct ctctcggaat aagacagagg tcgacattta taactcagac 1140 cccctgatct gccgggcagg gctgaaggtg tgcttcggca tccaactgct gaatgccgtc 1200 tcacgggtgg agcgcgccct ccccaagctg actgtgccct tcctgctgct ccagggctct 1260 gccgatcgcc tatgtgacag caaaggggcc tacctgctca tggagttagc caagagccag 1320 gacaagactc tcaagattta tgaaggtgcc taccatgttc tccacaagga gcttcctgaa 1380 gtcaccaact ccgtcttcca tgaaataaac atgtgggtct ctcaaaggac agccacggca 1440 ggaactgcgt ccccaccctg aatgcattgg ccggtgcccg gctcatggtc tgggggatgc 1500 aggcagggga agggcagaga tggcttctca gatatggctt gcaaaaaaaa aaaaaaaaaa 1560 aaaaaaaaaa aaa 1573 <210> SEQ ID NO 16 <211> LENGTH: 1695 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 atgtggttct gcgcgtgtgc ggacggctgt ctgttaactc cgcggtcagt tcccggactg 60 gtggctggtc tgcagggttg acctgcgcaa tgcagaggct gcaggtagtg ctgggccacc 120 tgaggggtcc ggccgattcc ggctggatgc cgcaggccgc gccttgcctg agcggtgccc 180 cgcaggcctc ggccgcggac gtggtggtgg tgcacgggcg gcgcacggcc atctgccggg 240 cgggccgcgg cggcttcaag gacaccaccc ccgacgagct tctctcggca gtcatgaccg 300 cggttctcaa ggacgtgaat ctgaggccgg aacagctggg ggacatctgt gtcggaaatg 360 tgctgcagcc tggggccggg gcaatcatgg cccgaatcgc ccagtttctg agtgacatcc 420 cggagactgt gcctttgtcc actgtcaata gacagtgttc gtcggggcta caggcagtgg 480 ccagcatagc aggtggcatc agaaatgggt cttatgacat tggcatggcc tgtggggtgg 540 agtccatgtc cctggctgac agagggaacc ctggaaatat tacttcgcgc ttgatggaga 600 aggagaaggc cagagattgc ctgattccta tggggataac ctctgagaat gtggctgagc 660 ggtttggcat ttcacgggag aagcaggata cctttgccct ggcttcccag cagaaggcag 720 caagagccca gagcaagggc tgtttccaag ctgagattgt gcctgtgacc accacggtcc 780 atgatgacaa gggcaccaag aggagcatca ctgtgaccca ggatgagggt atccgcccca 840 gcaccaccat ggagggcctg gccaaactga agcctgcctt caagaaagat ggttctacca 900 cagctggaaa ctctagccag gtgagtgatg gggcagctgc catcctgctg gcccggaggt 960 ccaaggcaga agagttgggc cttcccatcc ttggggtcct gaggtcttat gcagtggttg 1020 gggtcccacc tgacatcatg ggcattggac ctgcctatgc catcccagta gctttgcaaa 1080 aagcagggct gacagtgagt gacgtggaca tcttcgagat caatgaggcc tttgcaagcc 1140 aggctgccta ctgtgtggag aagctacgac tcccccctga gaaggtgaac cccctggggg 1200 gtgcagtggc cttagggcac ccactgggct gcactggggc acgacaggtc atcacgctgc 1260 tcaatgagct gaagcgccgt gggaagaggg catacggagt ggtgtccatg tgcatcggga 1320 ctggaatggg agccgctgcc gtctttgaat accctgggaa ctgagtgagg tcccaggctg 1380 gaggcgctac gcagacagtc ctgctgctct agcagcaagg cagtaacacc acaaaagcaa 1440 aaccacatgg gaaaactcag cactggtggt ggtggcagtg gacagatcaa ggcacttcaa 1500 ctcatttgga aaatgtgaac actgatgaca tggtatagga gtgggtgggg tgttgagcca 1560 cccatcagac cctctttagc tgtgcaagat aaaagcagcc tgggtcaccc aggccacaag 1620 gccatggtta attcttaagg caaggcaaat ccatggatga gaagtgcaat gggcatagta 1680 aaagtgcatg aattt 1695 <210> SEQ ID NO 17 <211> LENGTH: 1936 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 ctggagtttg cggagggccg agccgggtgc gcacggggag gcggaggcag cggcggcggc 60 ggcggcggcg gcggcggcgg agcagatgaa gaaactgagg ccctgtgatg tgaagtgact 120 tgccccccag ccacacagct ggaccattct ggctgctgtc tggacaagaa gtcgtagggg 180 gtgagggtgg aagctgggaa acccacagga ggcaaccaca ctagtttaga tcttctggtg 240 accccacttc tcgctgctca tgccgctggg actggggcgg cggaaaaagg cgccccctct 300 agtggaaaat gaggaggctg agccaggccg tggagggctg ggcgtggggg agccagggcc 360 tctgggcgga ggtgggtcgg ggggccccca aatgggcttg cccccccctc ccccagccct 420 gcggccccgc ctcgtgttcc acacccagct ggcccatggc agtcccactg gccgcatcga 480 gggcttcacc aacgtcaagg agctgtatgg caagatcgcc gaggccttcc gcctgccaac 540 tgccgaggtg atgttctgca ccctgaacac ccacaaagtg gacatggaca agctcctggg 600 gggccagatc gggctggagg acttcatctt cgcccacgtg aaggggcagc gcaaggaggt 660 ggaggtgttc aagtcggagg atgcactcgg gctcaccatc acggacaacg gggctggcta 720 cgccttcatc aagcgcatca aggagggcag cgtgatcgac cacatccacc tcatcagcgt 780 gggcgacatg atcgaggcca ttaacgggca gagcctgctg ggctgccggc actacgaggt 840 ggcccggctg ctcaaggagc tgccccgagg ccgtaccttc acgctgaagc tcacggagcc 900 tcgcaaggcc ttcgacatga tcagccagcg ttcagcgggt ggccgccctg gctctggccc 960 acaactgggc actggccgag ggaccctgcg gctccgatcc cggggccccg ccacggtgga 1020 ggatctgccc tctgcctttg aagagaaggc cattgagaag gtggatgacc tgctggagag 1080 ttacatgggt atcagggaca cggagctggc ggccaccatg gtggagctgg gaaaggacaa 1140 aaggaacccg gatgagctgg ccgaggccct ggacgaacgg ctgggtgact ttgccttccc 1200 tgacgagttc gtctttgacg tctggggcgc cattggggac gccaaggtcg gccgctacta 1260 ggactgcccc cggaccctgc gatgatgacc cgggcgcaac ctggtggggg cccccagcag 1320 ggacactgac gtcaggaccc gagcctccag cctgagccta gctcagcagc ccaaggacga 1380 tggtgagggg aggtggggcc aggccccctg ccccgctcca atcggtacca tcccctccct 1440 ggttcccagt ctggccgggg tccccggccc ccctgtgccc tgttccccac ctacctcagc 1500 tgggtcaggc acagggaggg gagggatcag ccaaattggg cggccacccc cgcctccacc 1560 actttccacc atcagctgcc aaactggtcc ctctgtctcc ctggggcctt gggttctgtt 1620 tgggggtcat gaccttccta gtttcctgac gcagggaata caggggagag ggttgtcctt 1680 ccccccagca aatgcaataa tgccctcacc cctcctgaga ggagccccct ccctgtggag 1740 cctgttacct ccgcatttga cacgagtctg ctgtgaaccc cgcaacctcc tccccacctc 1800 ccatctctcc ttccaggccc atccctggcc cagagcagga gggagggagg gacgatggcg 1860 gtgggttttt gtatctgaat ttgctgtctt gaacataaag aatctatctg ctgttaaaaa 1920 aaaaaaaaaa aaaaaa 1936 <210> SEQ ID NO 18 <211> LENGTH: 2318 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 gccacgaagg ccacagacgc cttccccctt ggactctcat tcccttttcc acggagcccc 60 gcgctttcgt gagccccctc gaggaacctg gtctccgcat ccagttacca cctcctgcct 120 cagaggccat ctgagccctt cgcacctcgc ccctcagtcc ccccttgccc ccccgcggag 180 atcgcctcgc tccctcccgc ccccccatca tcccttccct cgcagttccc ctgtcctgag 240 gggagccccg ccacggcagc gacagcgggc aggagggaga aagtgaaggt tgggcgacac 300 ttggcctcac tcccggctag gcgcacccac ggggaggaga ggaggagccg agagagctga 360 gcagcgcgga agtagctgct gctggtggtg acaatgtcaa ataacggcct agacattcaa 420 gacaaacccc cagcccctcc gatgagaaat accagcacta tgattggagt cggcagcaaa 480 gatgctggaa ccctaaacca tggttctaaa cctctgcctc caaacccaga ggagaagaaa 540 aagaaggacc gattttaccg atccatttta cctggagata aaacaaataa aaagaaagag 600 aaagagcggc cagagatttc tctcccttca gattttgaac acacaattca tgtcggtttt 660 gatgctgtca caggggagtt tacgggaatg ccagagcagt gggcccgctt gcttcagaca 720 tcaaatatca ctaagtcgga gcagaagaaa aacccgcagg ctgttctgga tgtgttggag 780 ttttacaact cgaagaagac atccaacagc cagaaataca tgagctttac agataagtca 840 gctgaggatt acaattcttc taatgccttg aatgtgaagg ctgtgtctga gactcctgca 900 gtgccaccag tttcagaaga tgaggatgat gatgatgatg atgctacccc accaccagtg 960 attgctccac gcccagagca cacaaaatct gtatacacac ggtctgtgat tgaaccactt 1020 cctgtcactc caactcggga cgtggctaca tctcccattt cacctactga aaataacacc 1080 actccaccag atgctttgac ccggaatact gagaagcaga agaagaagcc taaaatgtct 1140 gatgaggaga tcttggagaa attacgaagc atagtgagtg tgggcgatcc taagaagaaa 1200 tatacacggt ttgagaagat tggacaaggt gcttcaggca ccgtgtacac agcaatggat 1260 gtggccacag gacaggaggt ggccattaag cagatgaatc ttcagcagca gcccaagaaa 1320 gagctgatta ttaatgagat cctggtcatg agggaaaaca agaacccaaa cattgtgaat 1380 tacttggaca gttacctcgt gggagatgag ctgtgggttg ttatggaata cttggctgga 1440 ggctccttga cagatgtggt gacagaaact tgcatggatg aaggccaaat tgcagctgtg 1500 tgccgtgagt gtctgcaggc tctggagttc ttgcattcga accaggtcat tcacagagac 1560 atcaagagtg acaatattct gttgggaatg gatggctctg tcaagctaac tgactttgga 1620 ttctgtgcac agataacccc agagcagagc aaacggagca ccatggtagg aaccccatac 1680 tggatggcac cagaggttgt gacacgaaag gcctatgggc ccaaggttga catctggtcc 1740 ctgggcatca tggccatcga aatgattgaa ggggagcctc catacctcaa tgaaaaccct 1800 ctgagagcct tgtacctcat tgccaccaat gggaccccag aacttcagaa cccagagaag 1860 ctgtcagcta tcttccggga ctttctgaac cgctgtctcg atatggatgt ggagaagaga 1920 ggttcagcta aagagctgct acagcatcaa ttcctgaaga ttgccaagcc cctctccagc 1980 ctcactccac tgattgctgc agctaaggag gcaacaaaga acaatcacta aaaccacact 2040 caccccagcc tcattgtgcc aagctctgtg agataaatgc acatttcaga aattccaact 2100 cctgatgccc tcttctcctt gccttgcttc tcccatttcc tgatctagca ctcctcaaga 2160 ctttgatcct tggaaaccgt gtgtccagca ttgaagagaa ctgcaactga atgactaatc 2220 agatgatggc catttctaaa taaggaattt cctcccaatt catggatatg agggtggttt 2280 atgattaagg gtttatataa ataaatgttt ctagtctt 2318 <210> SEQ ID NO 19 <211> LENGTH: 571 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 19 tcagccggac accagaagac aagcagagag actcctccag acccactcag accacgtgca 60 cgccctccaa gatggtatcc cgtaaggctg tggctgctct gctggtggtg catgtagctg 120 ccatgctggc ctcccagacg gaagccttcg tccccatctt cacctatggc gaactccaga 180 ggatgcagga aaaggaacgg aataaagggc aaaagaaatc cctgagtgta tggcagaggt 240 ctggggagga aggtcctgta gaccctgcgg agcccatcag ggaagaagaa aacgaaatga 300 tcaagctgac tgctcctctg gaaattggaa tgaggatgaa ctccagacag ctggaaaagt 360 acccggccac cctggaaggg ctgctgagtg agatgcttcc ccagcatgca gccaagtgat 420 ggccacgctg gggagaaggt ggacagattt gggaggcccc tcctgcccaa gtgaggccct 480 gggaatttac agagcctgcc agctgggctt ggaaggaaaa cacctttcca aagcaaattc 540 ccctccagca aataaagcat gaaatataca g 571 <210> SEQ ID NO 20 <211> LENGTH: 3139 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 ggccgaggag gaagtggcgg cggcggcggc gggactgcgc gccccagctc cgatccccgt 60 tccgcgtccc cgccgccggg aggaggtgcc cactcgctcg cggcgcgcgc cggccgccag 120 actcggcctg tgggcgattt cctccggacc caggctcccc gcccgaggag gaagatgcag 180 acctttctga aagggaagag agttggctac tggctgagcg agaagaaaat caagaagctg 240 aatttccagg ccttcgccga gctgtgcagg aagcgaggga tggaggttgt gcagctgaac 300 cttagccggc cgatcgagga gcagggcccc ctggacgtca tcatccacaa gctgactgac 360 gtcatccttg aagccgacca gaatgatagc cagtccctgg agctggtgca caggttccag 420 gagtacatcg atgcccaccc tgagaccatc gtcctggacc cgctccctgc catcagaacc 480 ctgcttgacc gctccaagtc ctatgagctc atccggaaga ttgaggccta catggaagac 540 gacaggatct gctcgccacc cttcatggag ctcacgagcc tgtgcgggga tgacaccatg 600 cggctgctgg agaagaacgg cttgactttc ccattcattt gcaaaaccag agtggctcat 660 ggcaccaact ctcacgagat ggctatcgtg ttcaaccagg agggcctgaa cgccatccag 720 ccaccctgcg tggtccagaa tttcatcaac cacaacgccg tcctgtacaa ggtgttcgtg 780 gttggcgagt cctacaccgt ggtccagagg ccctcactca agaacttctc cgcaggcaca 840 tcagaccgtg agtccatctt cttcaacagc cacaacgtgt caaagccgga gtcgtcatcg 900 gtcctgacgg agctggacaa gatcgagggc gtgttcgagc ggccgagcga cgaggtcatc 960 cgggagctct cccgggccct gcggcaggca ctgggcgtgt cactcttcgg catcgacatc 1020 atcatcaaca accagacagg gcagcacgcc gtcattgaca tcaatgcctt cccaggctac 1080 gagggcgtga gcgagttctt cacagacctc ctgaaccaca tcgccactgt cctgcagggc 1140 cagagcacag ccatggcagc cacaggggac gtggccctgc tgaggcacag caagcttctg 1200 gccgagccgg cgggcggcct ggtgggcgag cggacatgca gcgccagccc cggctgctgc 1260 ggcagcatga tgggccagga cgcgccctgg aaggctgagg ccgacgcggg cggcaccgcc 1320 aagctgccgc accagagact cggctgcaac gccggcgtgt cgcccagctt ccagcagcat 1380 tgtgtggcct ccctggccac caaggcctcc tcccagtagc cacggagccg ggacccagag 1440 gggcagcgca gggcgcagag cacacccgct gggccagcag ctcccaacgg cgatgctact 1500 actaagaatc cccagtgatc tgattcttct gttttttaat ttttaacctg attctctgat 1560 gtcatgatct aaatgagggg tagtggggga tggaagagag taccaggtgg tccaccgttg 1620 gggagtgggg ccgtccgcct gctctctact gtgcagacct cctaactgag tttacacacg 1680 cttgtgtttg caacactagg tctggatggg aggtgagggg tgtgcgtatg gctgccatgc 1740 cggtgtctgt gcacatccct gtctgttggt ctccatggcc actgtggacc gggacccttg 1800 ggggaagcct gcccatgtcg ggctgtggga ggctgatcgg tgcatgtgag agtggcttcc 1860 cttctgcctg actccccact ccctgacctg ccccttcctt gtttttcctc ctactggtct 1920 ccaccaaggc tttgttagcc cccaccctgc ctggtgtgca gctaacccct ccctccccac 1980 agccagagga ggccacagac ccctcagggg agttccgcgc tggtgtctgg gctgtgctcc 2040 ctcactaaag ggaaggaaag gaagctgggc gtcctctggg ccccccaaca cacgtcccat 2100 ttagccctgc acagcggtct ccttccccta agccagcact gctgctccct ggagcccggg 2160 aaggaggctg cctggctgga ggcccgagcc gatggcgcct gtgctgagga tttgtgctgt 2220 gatttgggca aatcattcca ggtctttggg cctccacccc cttgtctcta gtggacattt 2280 gagatcagag agcaccacag ggctggcttt gtgccctaac ccctgggatg cagcctgcct 2340 ttccataaag tcacctaggt gaggataggc gcgggagcct cggcatgaca ccatggagat 2400 cggggccctc ttcccagtgg gttcactcct tttcacacct gctgggtccc tcctcaccca 2460 gcaggcctgg tccacctctc attgcaagcc ccaagcactg agccagcagg tgccagggag 2520 ccacccgccc cccatcgctt ctgcacacct cagactcacc ccatcacctt ggcagcaaag 2580 cactggctct gccgtctgac ccctgatcca ggcagccccc tctgcagaga aaagggttgg 2640 ggagaagcct ctgcagtcct ggaagatgtg gggtgctggg tgagaggcat cagcccccac 2700 aagtatgttt ttgtgtctta agatagcagt ttactttgaa aaagtgaaaa aggcttccgg 2760 gctgtcctct gcccagtgag atggaggacg ctagagaaag tgctgagtgt cccgagagag 2820 gcccccgagc cagtgcatgg aggtccttcg gcctggctca gctgggctgc aggatgccca 2880 ctttgaggag ggaggcacag ggcttgggcg aggggcagag gccatcagaa ctgcccggct 2940 tttttggaaa ctgaggaccc aacaactaac cacgtttaca cgacttgagt tttgaacccc 3000 gattaatgtc tgtacgtcac ctttcctagt tctgaccctg agccctgggg aacaggaaag 3060 cgtggctggc ctcttgcact gctttgtctc caaaataaac tactgaaatc aaaccgcaaa 3120 aaaaaaaaaa aaaaaaaaa 3139 <210> SEQ ID NO 21 <211> LENGTH: 3590 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 aaaatcagaa gagtggacac tggcaagagg agggcagcct ttttcccagc ttccttgcac 60 catggacagc tcccattaag ccacctctcc atcctggggc caggactctt atgccccatt 120 cctgtcaaat tgagatttca tccaccattc tccaaggaca gtgaagttat accctagttc 180 cagtgttggg atcagtggcc cctctggaca tgcctctcct ggaaggttct gtgggggtgg 240 aggatcttgt cctcctggaa cccttggtgg aggagtcact gctcaagaat cttcagcttc 300 gctatgaaaa caaggagatt tatacctaca ttgggaatgt ggtgatctca gtgaatccct 360 atcaacagct tcccatctat gggccagagt tcattgccaa atatcaagac tatactttct 420 atgagctgaa gccccatatc tacgcattgg caaatgtggc gtaccagtca ctgagggaca 480 gggaccgaga ccagtgtatc ctcatcacag gcgagagtgg atcagggaag actgaggcca 540 gcaagctggt gatgtcttat gtggctgccg tctgtgggaa aggagagcag gtgaactctg 600 tgaaggagca gctgctacag tctaacccag tgctggaggc ttttggcaat gccaagacca 660 ttcgcaacaa caattcctcc cgatttggaa aatacatgga tattgaattt gacttcaagg 720 gatcccccct cggtggtgtc atcacaaact atctgcttga gaaatcccga ttagtgaagc 780 agctcaaagg agaaaggaac ttccacatct tctatcagct gctggctgga gcagatgaac 840 agctgctgaa ggccctgaag cttgagcggg atacaactgg ctatgcctat ctgaatcatg 900 aagtatccag agtggatggc atggacgacg cctccagctt cagggctgta cagagtgcaa 960 tggcagtgat tgggttctcg gaggaggaga ttcgacaagt gctagaggtg acatccatgg 1020 tgctaaagct ggggaacgtg ttggtggctg atgagttcca ggccagtggg ataccagcaa 1080 gtggcatccg tgatgggaga ggtgttcggg agattgggga gatggtgggc ttgaattcag 1140 aagaagtaga gagagctttg tgctcgagga ccatggaaac agccaaggaa aaggtggtca 1200 ctgcactgaa tgttatgcag gctcagtatg ctcgggacgc cctggctaag aacatctaca 1260 gccgcctctt tgactggata gtgaatcgaa tcaatgagag catcaaggtg ggcatcgggg 1320 aaaagaagaa ggtaatggga gtccttgata tctacggttt tgagatatta gaggataata 1380 gctttgagca atttgtgatc aactactgca atgagaagct gcagcaggtg ttcatagaga 1440 tgaccctgaa agaagagcaa gaggaatata agagagaagg cataccgtgg acaaaggtgg 1500 actactttga taatggcatc atttgtaagc tcattgagca taatcagcga ggtatcctgg 1560 ccatgttgga tgaggagtgc ctgcggcctg gggtggtcag tgactccact ttcctagcaa 1620 agctgaacca gctcttctcc aagcatggcc actacgagag caaagtcacc cagaatgccc 1680 agcgtcagta tgaccacacc atgggcctca gctgcttccg catctgccac tatgcgggca 1740 aggtgacata caacgtgacc agctttattg acaagaataa tgacctactc ttccgagacc 1800 tgttgcaggc catgtggaag gcccagcacc ccctccttcg gtccttgttt cctgagggca 1860 atcctaagca ggcatctctc aaacgccccc cgactgctgg ggcccagttc aagagttctg 1920 tggccatcct catgaagaat ctgtattcca agagccccaa ctacatcagg tgcataaagc 1980 ccaatgagca tcagcagcga ggtcagttct cttcagacct ggtggcaacc caggctcggt 2040 acctgggact gctggagaac gtacgggtgc gacgggcagg ctatgcccac cgccagggtt 2100 atgggccctt cctggaaagg taccgattgc tgagccggag cacctggcct cactggaatg 2160 ggggagaccg ggaaggtgtt gagaaggtcc tgggggagct gagcatgtcc tcgggggagc 2220 tggcctttgg caagacaaag atcttcatta gaagccccaa gactcttttc tacctcgaag 2280 aacagaggcg cctgagactc cagcagctgg ccacactcat acagaagatt taccgaggct 2340 ggcgctgccg cacccactac caactgatgc gaaagagtca gatcctcatc tcctcttggt 2400 ttcggggaaa catgcaaaag aaatgctatg ggaagataaa ggcatccgtg ttattgatcc 2460 aggcttttgt gagagggtgg aaggcccgaa agaattatcg caaatatttc cggtcagagg 2520 ctgccctcac cttggcagat ttcatctaca agagcatggt acagaaattc ctactggggc 2580 tgaagaacaa tttgccatcc acaaacgtct tagacaagac atggccagcc gccccctaca 2640 agtgcctcag cacagcaaat caggagctgc agcagctctt ctaccagtgg aagtgcaaga 2700 ggttccggga tcagctgtcc ccgaagcagg tagagatcct gagggaaaag ctctgtgcca 2760 gtgaactgtt caagggcaag aaggcttcat atccccagag tgtccccatt ccattctgtg 2820 gtgactacat tgggctgcaa gggaacccca agctgcagaa gctgaaaggc ggggaggagg 2880 ggcctgttct gatggcagag gccgtgaaga aggtcaatcg tggcaatggc aagacttctt 2940 ctcggattct cctcctgacc aagggccatg tgattctcac agacaccaag aagtcccagg 3000 ccaaaattgt cattgggcta gacaatgtgg ctggggtgtc agtcaccagc ctcaaggatg 3060 ggctctttag cttgcatctg agtgagatgt catcggtggg ctccaagggg gacttcctgc 3120 tggtcagcga gcatgtgatt gaactgctga ccaaaatgta ccgggctgtg ctggatgcca 3180 cgcagaggca gcttacagtc accgtgactg agaagttctc agtgaggttc aaggagaaca 3240 gtgtggctgt caaggtcgtc cagggccctg caggtggtga caacagcaag ctacgctaca 3300 aaaaaaaggg gagtcattgc ttggaggtga ctgtgcagtg aggagggggc accatgcaga 3360 gatggcagtt gcttcctcct gaaccagcac taatccccct ctgccctcct gtgtgggagg 3420 atctctaacc cctctgatcg tggcgcatgg cttggggatt aaactaccct tgaagaggac 3480 ccttgtccca aacccttctt gttctctcct ccaaaagtag cttcctccaa cccgcagcct 3540 ctctgcacac taataaaaca tgtggcttgg aaaggtccaa aaaaaaaaaa 3590 <210> SEQ ID NO 22 <211> LENGTH: 3008 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 taagaatgtc ttttccacct catttgaatc gccctcccat gggaatccca gcactcccac 60 cagggatccc acccccgcag tttccaggat ttcctccacc tgtacctcca gggaccccaa 120 tgattcctgt accaatgagc attatggctc ctgctccaac tgtcttagta cccactgtgt 180 ctatggttgg aaagcatttg ggcgcaagaa aggatcatcc aggcttaaag gctaaagaaa 240 atgatgaaaa ttgtggtcct actaccactg tttttgttgg caacatttcc gagaaagctt 300 cagacatgct tataagacaa ctcttagctc cttcggattc tgtgagtaca aggagccaga 360 atctaccctc cgtgcactca gattattaca tgacctgcaa attggagaga aaaagctact 420 cgttaaagtt gatgcaaaga caaaggcaca gctggatgaa tggaaagcaa agaagaaagc 480 ttctaatggg gttgggatga aagtagtaag ggaggctgga caaggttaac ttgccagaga 540 aagcactggt acagactatt ccaaacagag ctaattcatt aaggcagctt tgtaaaatgc 600 aaggccagaa actgtcacta atgacgatga agaagccttg gatgaagaaa caaagaggag 660 agatcagatg attaaagggg ctattgaagt tttaattcgt gaatactcca gtgagctaaa 720 tgccccctca caggaatctg attctcaccc caggaagaag aagaaggaaa agaaggagga 780 cattttccgc agatttccag tggccccact gatcccttat ccactcatca ctaaggagga 840 tataaatgct atagaaatgg aagaagacaa aagagacctg atatctcgag agatcagcaa 900 attcagagac acacataaga aactggaaga agagaaaggc aaaaaggaaa aagaaagaca 960 ggaaattgag aaagaacgga gagaaagaga gagggagcgt gaaagggaac gagaaaggcg 1020 agaacgggaa cgagaaaggg aaagagaacg tgaacgagaa aaggagaaag aacgggagcg 1080 ggaacgagaa cgggataggg accgtgaccg gacaaaagag agagaccgag atcgggatcg 1140 agagagagat cgtgaccggg atagagaaag gagctcagat cgtaataagg atcgcagtcg 1200 atcaagagaa aaaagcagag atcgtgaaag ggaacgagag cgggaaagag agagagagag 1260 agaacgagag cgagaacgag aacgggagcg agagagagag cgagagaggg aacgggagcg 1320 agaaagagaa aaagacaaaa aacgggaccg agaagaagat gaagaagatg catacgaacg 1380 aagaaaactt gaaagaaaac tccgagagaa agaagctgct tatcaagagc gccttaagaa 1440 ttgggaaatc agagaacgaa agaaaacccg ggaatatgag aaagaagctg aaagagaaga 1500 agaaagaaga agagaaatgg ccaaagaagc taaacgacta aaagaattct tagaagacta 1560 tgatgatgat agagatgacc ccaaatatta cagaggaagt gctcttcaga aaaggttgcg 1620 tgatagagaa aaggaaatgg aagcagatga acgagatagg aagagagaga aggaggagct 1680 tgaggaaatc aggcagcgcc ttctggcaga agggcatcca gatccagatg cagagctcca 1740 gaggatggaa caagaggctg agaggcgcag gcagccacaa ataaagcaag agccagaatc 1800 agaagaggag gaagaagaaa agcaagaaaa agaagaaaaa cgagaagaac ccatggaaga 1860 ggaagaggag ccagagcaaa agccttgtct gaaacctact ctgaggccca tcagctctgc 1920 tccatctgtt tcctctgcca gtggcaatgc aacacctaac actcctgggg atgagtctcc 1980 ctgtggtatt attattcctc atgaaaactc accagatcaa cagcaacctg aggagcatag 2040 gccaaaaata ggactaagtc ttaaactggg tgcttccaat agtcctggtc agcctaattc 2100 tgtgaagaga aagaaactac ctgtagatag tgtctttaac aaatttgagg atgaagacag 2160 tgatgacgta ccccgaaaaa ggaaactggt tcccttggat tatggtgaag atgataaaaa 2220 tgcaaccaaa ggcactgtaa acactgaaga aaagcgtaaa cacattaaga gtctcattga 2280 gaaaatccct acagccaaac ctgagctctt cgcttatccc ctggattggt ctattgtgga 2340 ttctatactg atggaacgtc gaattagacc atggattaat aagaaaatca tagaatatat 2400 aggtgaagaa gaagctacat tagttgattt tgtttgttct aaggttatgg ctcatagttc 2460 accccagagc attttagatg atgttgccat ggtacttgat gaagaagcag aagtttttat 2520 agtcaaaatg tggagattat tgatatatga aacagaagcc aagaaaattg gtcttgtgaa 2580 gtaaaacttt ttatatttag agttccattt cagatttctt ctttgccacc cttttaagga 2640 ctttgaattt ttctttgtct ttgaagacat tgtgagatct gtaatttttt ttttttgtag 2700 aaaatgtgaa ttttttggtc ctctaatttg ttgttgccct gtgtactccc ttggttgtaa 2760 agtcatctga atccttggtt ctctttatac tcaccaggta caaattactg gtatgtttta 2820 taagccgcag ctactgtaca cagcctatct gatataatct tgttctgctg atttgtttct 2880 tgtaaatatt aaaacgactc cccaattatt ttgcagaatt gcacttaata ttgaaatgta 2940 ctgtatagga accaacatga acaattttaa ttgaaaacac cagtcataaa ctattaccac 3000 ccccactc 3008 <210> SEQ ID NO 23 <211> LENGTH: 4540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 23 attctggggt tcgtttagag gtttgaattt tctcggagaa agacaggccg gccacgagga 60 aaacagaaac aagccgcagc aacatctaag cccttgaaag gatcctgaga gaggggggaa 120 agggaaaaca gcagccacca gcccaaccac ttgtgtcttc tgccccttcc cacctatctt 180 gcccacccca ccagcccacg ctgcttggga cttgaaatct gtggccgaag gaccgtcact 240 acataacttc aaaaataatc aaccaccctc ccttcccaaa ccacccaaat tcactcatcc 300 agcgtttact tttttgaatc cactcagaac ttttttctgc gacccccctc cctaaatgga 360 gttgggtggg ggggaaatga atactgagtt ggcctttatt ttttaaaaga ctttttgatc 420 caatgaggcc ccctaaataa ttgagttttg ggtcctggtt ggttgtttta ttttttttcc 480 tccaaaattt taccccctcc cccctgagcc cgaggtgctg acgtcgcaaa aaaattggat 540 aaaaccacca tcatgggttc gggtcccata gaccccaaag aacttctcaa gggcctggac 600 agcttcctta accgagatgg ggaagtcaaa agtgtggatg ggatttccaa gatcttcagt 660 ttgatgaagg aagcacgaaa gatggtgagt cgatgcactt acttgaacat tctcctgcag 720 acccgttcac cagaaatatt ggtcaaattt attgacgttg gcggctacaa acttcttaac 780 aattggctga cgtattcaaa gacaaccaac aacattcccc tcctccagca aattctactg 840 accctgcagc atctaccgct cactgtagac catctcaagc agaacaacac agctaaactg 900 gtgaagcagc tgagcaagtc aagtgaggat gaagagctcc ggaaattggc ctcagtcctt 960 gtcagcgact ggatggctgt catccgctct cagagcagta cccagcctgc tgagaaagat 1020 aagaagaaac gtaaagatga aggaaaaagt cgaactaccc ttcctgagcg acctttgaca 1080 gaggtgaagg ctgagacccg ggctgaggag gccccagaga agaagaggga gaagcccaag 1140 tctcttcgca ccacagcacc cagtcatgcc aagttccgtt ccactggact agagctggag 1200 acaccatcct tggtgcctgt gaagaagaat gccagcacag tggtggtttc tgacaagtac 1260 aaccttaaac ccatccccct caaacgtcag agcaacgtag ctgctccagg agatgccact 1320 ccccctgcag agaagaaata caagccactc aacacaacac ctaatgccac caaagagatc 1380 aaagtgaaga tcatcccgcc acagcctatg gagggcctgg gctttctgga tgctcttaat 1440 tcagcccctg ttccaggcat caaaattaag aagaaaaaaa aagtactgtc acctacggct 1500 gccaagccaa gcccctttga agggaaaacg agcacagaac caagcacagc caaaccttct 1560 tccccagaac cagcaccacc ttctgaggca atggacgcag accgtccagg caccccggtt 1620 ccccctgttg aagtcccgga gctcatggat acagcctctt tggagccagg agctctggat 1680 gccaagccag tggagagtcc tggagatcct aaccaactga cccggaaagg caggaagagg 1740 aaaagtgtga catggcctga ggaaggcaaa ctgagagaat atttctattt tgaattggat 1800 gaaactgaac gagtaaatgt gaataagatc aaggactttg gtgaggcggc taagcgagag 1860 atactgtcag accgacatgc atttgagaca gcgcggcgtc tgagccatga taacatggag 1920 gagaaggtgc cctgggtgtg cccccggccc ctggttctgc cctcacctct tgtcacccct 1980 ggaagcaata gtcaggagcg atatatccag gctgagcggg agaagggaat ccttcaggag 2040 ctcttcctga acaaggagag tcctcatgag cctgatcctg agccctacga gcccataccc 2100 cctaaactca tccccctaga tgaggagtgt tccatggatg agactccgta tgttgagact 2160 ctggaacctg gggggtcagg tggctcacct gatggggcag gaggctccaa gttgcctcca 2220 gttctggcca atcttatggg aagcatgggt gctggaaagg gcccccaagg ccctggagga 2280 ggaggcatta atgtccaaga gatcctcacc tccatcatgg gtagcccaaa cagtcatcct 2340 tcagaggaac tactgaaaca accagactat tcggacaaga tcaagcagat gctggtgcca 2400 catggactcc taggccctgg cccaatagcc aatggtttcc caccaggggg tcctgggggc 2460 cccaagggca tgcagcactt tccccctgga cctgggggac ctatgccagg tccccatgga 2520 ggccctggtg ggccagtggg tccacgtctt ctgggtcctc caccccctcc ccggggaggt 2580 gatcccttct gggatggccc gggcgaccct atgcggggtg gcccaatgcg ggggggtcca 2640 ggaccaggtc ctggaccata ccatagaggc cgaggtggcc gaggaggaaa cgaacctcct 2700 cctcctcctc ctccattccg aggcgccaga ggaggtcgct ctggaggagg acccccaaat 2760 ggacgagggg gccctggtgg gggcatggtt ggaggtggtg ggcatcgtcc tcacgaaggc 2820 cctggtgggg gcatgggcaa cagcagtgga catcgtcccc acgaaggccc tggcggtggc 2880 atgggaagtg ggcatcgccc ccatgaaggc cctggtggta gcatgggtgg gggtggagga 2940 catcgtcccc acgaaggccc tggcggtggc atcagtggtg gcagtggcca tcgtccccat 3000 gaaggccctg gcggaggaat gggtgccggt ggtggacatc gcccccacga aggccctggc 3060 ggaagcatgg gtggaagtgg tggacatcgt ccccatgaag gccctggaca cggggggccc 3120 catggccacc ggcctcatga tgtccctggt caccgaggcc atgaccatcg agggccgcca 3180 cctcatgagc accgtggcca tgatggtcct ggccacgggg gagggggcca ccgagggcac 3240 gatggaggcc acagccatgg aggagacatg tcaaaccgcc ctgtctgccg acatttcatg 3300 atgaagggca actgccgcta tgagaacaac tgtgccttct accacccggg tgtcaatggg 3360 ccccccctgc cctagggacc atttgcctgc cctgttcaca caacccctgt ggactgcagc 3420 ctcgctcttt ccaccctgtt atggcttctg tgaggcccat tttccctttt ccccagctga 3480 tgaggagccg gccccctcag ttcccacttg cttgggttcc tgggggtttt ctgatcactg 3540 gtgcgcattg atgtacatat tttcctccag tctggggagg agagagactg gaaacgttcc 3600 tggactgctg aagaggagac ccagttggct tcactttttg agaagattcg ccctgtaccc 3660 caaacccctt tccagtatta cccttaatgc ttgagaacct aaagctggtt atcctggcga 3720 acacccctac ccttctattg cgggtcccca catgcacaca gaactctgac acaggatcag 3780 ctgcacttaa gaaatcatcc cagctaagtt cattattcct catggggtgg ggagatgctg 3840 aaaggggtat tgtatatccc actgcactga gagggctcaa tcagctggat ttgagttctg 3900 gaacacacat catccccacc cctcccccag cgtgggctca ccattcttag tcctttctca 3960 agtgggacct tcaactttct gtgaacaccc agtctgcgtc ctgggtctgc taggttcgat 4020 gatggcgaac tcgtatctgc atccggtgca agttttagct ggcagaggtg agaccggtgg 4080 tgctggtctg cctttgccaa ctatagccag tctggagact tgataaaata cttcagtgag 4140 accagcttct catcaacttg ggcccggcgt gctgggcctg aaagtcacac tacatgcact 4200 gcctttggga gtcagctcac tccctgctcc cacctggaac cttgccagcg tgaaggaggc 4260 ttccaggtac ttcaccctgt caaccacctc tgaatcccca ccaggcgcct tcctgggtgg 4320 attcaacaag atgattttgc cctttcccag ttctctcctt cactttggca tcagttgttt 4380 tctatgaaaa cagtggattg gttgggtttt gtgcagggtc ttgggttaga gccaaaatgg 4440 atttgaggat gagtattttt ttttttggtt ttgtatattt tgtacattaa taataaacag 4500 tggaaagaga agcagcttaa aaaaaaaaaa aaaaaaaaaa 4540 <210> SEQ ID NO 24 <211> LENGTH: 3233 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 tgcgactgag tcggtggcga agacgggaac gcgacgatgg cggagactct gcccgggtcg 60 ggcgactcgg gccctggcac ggcttctctc ggcccgggcg ttgcggagac tgggacgagg 120 cggctcagcg agctgcgggt gatcgatctg cgggcggagc tgaagaagcg gaacctggac 180 acgggcggca acaagagcgt cctgatggag cggctcaaga aggcggttaa agaagagggg 240 caagatcctg atgaaattgg catcgagtta gaagccacca gcaagaagtc agccaagaga 300 tgtgttaaag gactgaagat ggaggaggaa ggcacagaag ataatggcct ggaagacgat 360 tccagagacg ggcaggagga catggaagca agtctggaga acctgcagaa tatgggcatg 420 atggacatga gtgtgctaga cgaaactgaa gtggcgaata gcagtgctcc agattttggg 480 gaggatggca cggacggcct tctcgattcc ttttgtgata gtaaagaata cgtggctgca 540 cagctgagac agctcccggc tcagccccca gagcatgctg tggatgggga aggatttaag 600 aacactttgg aaacttcatc gttgaacttc aaagtaactc cggacattga agaatccctt 660 ttggagccag aaaatgagaa aatactcgac attttggggg aaacttgtaa atctgagcca 720 gtaaaagaag aaagttccga gctggagcag ccatttgcac aggacacaag tagcgtgggg 780 ccagacagaa agcttgcgga ggaagaggac ctatttgaca gcgcccatcc ggaagagggt 840 gatttagatt tggccagcga gtcaacagca cacgctcagt cgagcaaggc agacagcctg 900 ttagcggtag tgaaaaggga gcccgcggag cagccaggcg atggcgagag gacggactgt 960 gagcctgtag ggctagagcc ggcagttgag cagagtagtg cggcctccga gctcgcggag 1020 gcctctagcg aggagctcgc agaagcaccc acggaagccc caagcccaga agccagagat 1080 agcaaagaag acgggaggaa gtttgatttt gacgcttgta atgaagtccc tccggctcct 1140 aaagagtcct caaccagtga gggcgctgat cagaaaatga gctcttttaa ggaagaaaaa 1200 gatataaagc caatcattaa agatgaaaaa ggtcgggtcg gcagcggttc tggtcggaac 1260 ctgtgggtca gcgggctgtc ctccacaaca cgcgctacgg atctcaagaa ccttttcagc 1320 aagtatggga aggttgtcgg ggccaaagtg gtaacgaacg cccgcagccc gggggctcga 1380 tgctatggat tcgtcaccat gtcgacatct gacgaggcga ccaagtgcat cagccatctc 1440 cacagaactg agctgcatgg acgaatgatc tccgtagaga aggccaaaaa tgagcctgct 1500 gggaaaaagc tttccgacag aaaagagtgc gaagtgaaga aggaaaaatt atcgagtgtc 1560 gacagacatc attctgtgga gatcaaaatt gaaaaaactg taattaagaa ggaagagaag 1620 attgagaaga aggaggaaaa aaagcctgaa gacattaaga aggaagaaaa agaccaggat 1680 gagctgaaac ccggacctac aaatcggtct agagtcacca aatcaggaag cagaggaatg 1740 gagcggacgg tcgtgatgga taaatcgaaa ggagagcccg tcattagcgt gaaaaccaca 1800 agcaggtcca aagagagaag ctccaagagt caggatcgca agtcagaaag caaagaaaag 1860 agagacatct tgtcgtttga taaaatcaaa gaacaaaggg agagagagcg ccagaggcag 1920 cgggaacggg agatccgcga aacggagagg cggcgggagc gcgagcagcg ggagcgggag 1980 caacgcctcg aggccttcca tgagcggaag gagaaggccc ggctacagcg ggaacgcctg 2040 cagctcgagt gccagcgcca gcggctggag cgggagcgca tggagcggga gcggctggag 2100 cgcgagcgca tgcgcgtgga gcgtgagcgc aggaaggagc aggagcgcat ccaccgcgag 2160 cgcgaggagc tgcggcgcca gcaggagcag ctgcgttacg agcaggagcg gcggcccggg 2220 cggaggccct acgacctgga ccgacgagat gatgcctatt ggccagaagg aaagcgtgtg 2280 gcaatggagg accgatatcg tgcagacttt ccccggccag accaccgctt tcacgacttc 2340 gatcatcgag accggggcca gtaccaggac cacgccatcg acaggcggga gggttcgagg 2400 ccaatgatgg gagaccaccg ggatgggcag cactatggag atgaccgcca tggccacgga 2460 ggacccccag agcgccacgg ccgggactcc cgtgatggct gggggggcta cggctccgac 2520 aagaggctga gtgaaggccg ggggctgccc cctcccccca ggggtggccg tgactgggga 2580 gagcacaacc agcggctaga ggagcaccag gcacgcgcct ggcagggtgc catggacgca 2640 ggcgcggcta gccgggagca cgccaggtgg caaggtggcg agaggggcct gtctgggccc 2700 tcggggccgg ggcacatggc aagccgcggt ggagtggcgg ggcgaggcgg ctttgcacaa 2760 ggtggacatt cccagggcca cgtggtgcca ggtggcggac tggaaggtgg cggagtggcc 2820 agccaggacc ggggcagcag agtccctcac ccacaccctc atcccccccc gtacccccac 2880 ttcacccgcc gctactaagt cccactcgct gtgagttttc gggtgggcag acgcactgtt 2940 gaatctggta gccagggttc cctcgaactt gggggatctt tttaaaagca aagtaaatcc 3000 tgccaccatg ttgtagctca atacaatgtg aactcacttt tttttttttt tttaataaat 3060 gtgttcttgt tctgccattt ttaaatcaag gtttctgtta acgaggcatt ccattttcca 3120 ttaataaagt ttaccattcg caaaaaaaaa atgtgttctt gttctgccat ttttaaatca 3180 aggtttctgt taacgaggca ttccattttc cattaataaa gtttaccatt cgc 3233 <210> SEQ ID NO 25 <211> LENGTH: 17847 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 25 atgggtgccc cgagcgcgtg ccggacgctg gtgttggctc tggcggccat gctcgtggtg 60 ccgcaggcag agtgcacggg cagatccccc tacgactccc tgagtgtcct ggatgggacc 120 ctacccgtcc ccaacacagg gctctggggc cccacgggct cacagtgtca ggaaactcag 180 gggctggctt ggatggggtg tccaggagaa gagacccagg gccctgtgga gccgagctgg 240 gagaatgcag ggcacaccat ggatggcggt gccccgacgt cctcgcccac ccggcgcgtg 300 agctttgttc cacccgtcac tgtcttcccc agcctgagcc gtaagcagat gctgcccctg 360 ccagccggga agggggtgtt tgccagtccc aaaggtgggg gcccagatct aggggtgcag 420 ctgccaccag ccctgaaccc ggcgcacaat gggcgggtgt gcagcacctg gggtgacttc 480 cactacaaga ccttcgacgg cgacgtcttc cgcttccctg gcctttgcaa ctacgtgttc 540 tctgagcact gccgcgccgc ctacgaggac ttcaacgtcc agctacgccg aggcctagtg 600 ggctccaggc ctgtggtcac ccgtgttgtc atcaaggccc aggggctggt gctggaggcg 660 tccaacggct ccgtcctcat caatgggcag cgggaggagc tgccttacag ccgcactggc 720 ctcctggtgg agcagagcgg ggactacatc aaggtcagca tccggctggt gctgacattc 780 ctgtggaacg gagaggacag tgccctgctg gagctggatc ccaaatacgc caaccagacc 840 tgtggcctgt gtggggactt caacggcctc ccggccttca acgagttcta tgcccacaac 900 gccaggctga ccccgctcca gtttgggaac ctgcagaagt tggatgggcc cacggagcag 960 tgcccggacc cgctgccctt gccggccggc aactgcacgg acgagccccc atggatggca 1020 ggggtgccca gcctggccca ctgtgctccc caggagggca tctgccaccg caccctgctg 1080 gggccggcct ttgcggagtg ccacgcactg gtggacagca ctgcgtacct ggccgcctgc 1140 gcccaggacc tgtgccgctg ccccacctgc ccgtgtgcca cctttgtgga atactcacgc 1200 cagtgcgccc acgcgggggg ccagccgcgg aactggaggt gccctgagct ctgcccccgg 1260 acctgccccc tcaacatgca gcaccaggag tgtggctcac cctgcacgga cacctgctcc 1320 aacccccagc gcgcgcagct ctgcgaggac cactgtgtgg acggctgctt ctgcccccca 1380 ggcacggtgc tggatgacat cacgcactct ggctgcctgc ccctcgggca gtgcccctgc 1440 acccacggcg gccgcaccta cagcccgggc acctccttca acaccacctg cagctcctgc 1500 acctgctccg gggggctatg gcagtgccag gacctgccgt gccctggcac ctgctctgtg 1560 cagggcgggg cccacatctc cacctatgat gagaaactct acgacctgca tggtgactgc 1620 agctacgttc tgtccaagag ccacatcccc cacatgggca tccccagcac acttctgggg 1680 ggcaccccac atcatcgagc caggcccaat gcacgcgtgg gtccttctcc ccagaaatgt 1740 gccgacagca gcttcaccgt gctggctgag ctgcggaagt gcggcctgac ggacaacgag 1800 aactgcctga aagcggtgac gctcagcctg gacggcgggg acacggccat ccgggtccaa 1860 gcggacggcg gcgtgttcct caactccatc tacacgcagc tgcccctgtc ggcagccaac 1920 atcaccctgt tcacaccctc gagcttcttc atcgtggtgc agacaggcct ggggctgcag 1980 ctgctggtgc agctggtgcc actcatgcag gtgtttgtca ggctggaccc cgcccaccag 2040 ggccagatgt gcggcctgtg tgggaacttc aaccagaacc aggctgacga cttcacggcc 2100 ctcagcgggg tggtggaggc cacgggcgca gccttcgcca acacctggaa ggcccaggct 2160 gcctgtgcca atgccaggaa cagctttgag gacccctgct ccctcagtgt ggagaatgag 2220 aactacgccc ggcactggtg ctcgcgcctg accgatccca acagtgcctt ctcgcgctgc 2280 cactccatca tcaaccccaa gcccttccac tcgaactgca tgtttgacac ctgcaactgt 2340 gagcggagcg aggactgcct gtgcgccgcg ctgtcctcct atgtgcacgc ctgtgccgcc 2400 aagggcgtac agctcagcga ctggagggac ggcgtctgca ccaagtacat gcagaactgc 2460 cccaagtccc agcgctacgc ctacgtggtg gatgcctgcc agcccacttg ccgcggcctg 2520 agtgaggccg acgtcacctg cagcgtttcc ttcgtgcctg tggacggctg cacctgcccc 2580 gcgggcacct tcctcaatga cgcgggcgcc tgtgtgcccg cccaggagtg cccctgctac 2640 gctcacggca ccgtgctggc tcctggagag gtggtgcacg acgagggcgc cgtgtggtaa 2700 gggtctgggg ggaaagcagg ccccccaggg tgtgcagccc ccatggtgta cctggactgc 2760 agcaacagct cggcgggcac ccctggggcc gagtgcctcc ggagctgcca cacgctggac 2820 gtgggctgtt tcagcacaca ctgcgtgtcc ggctgtgtct gtcccccggg gctggtgtcg 2880 gatgggagtg ggggctgcat tgccgaggag gactgcccct gtgtgcacaa cgaggccacc 2940 tacaagcctg gagagaccat cagggtcgac tgcaacacct gcacctgcag gaaccggagg 3000 tgggagtgca gccaccggct ctgcctgggc acctgcgtgg cctacgggga tggccacttc 3060 atcacctttg atggcgatcg ctacagcttt gaaggcagct gcgagtacat cttggcccag 3120 gactactgtg gggacaacac cacccacggg accttccgca tcgtcaccga gaacatcccc 3180 tgtgggacca ccggcaccac ctgctccaag gccatcaagc tcttcgtgga ggtgagaacg 3240 gccccagctg tgagcacccc cgaccctgca gccaacgagc cggcccccag ggaagcttcg 3300 gtcggcttcc ggcagcgtct gcctcccctg cagagctacg agctgatcct ccaagagggg 3360 acctttaagg cggtggcgag agggccgggt ggggacccac cctacaagat acgctacatg 3420 gggatcttcc tggtcatcga gacccacggg atggccgtgt cctgggaccg gaagaccagc 3480 gtgttcatcc gactgcacca ggactacaag ggcagggtct gcggcctgtg cgggaacttc 3540 gacgacaatg ccatcaatga ctttgccacg cgtagccggt ccgtggtggg ggacgcactg 3600 gagtttggga acagctggaa gctctccccc tcctgcccgg acgccctggc acccaaggac 3660 ccctgcacgg ccaacccctt ccgcaagtcc tgggcccaga agcagtgcag catcctccac 3720 ggccccacct tcgccgcctg ccgctcccag gttgactcca ccaagtacta cgaggcctgc 3780 gtgaacgacg cgtgtgcctg cgactcgggt ggcgactgcg agtgtttctg cacggctgtg 3840 gctgcctacg cccaggcctg ccacgacgcg ggcctgtgtg tgtcctggcg gactccggac 3900 acctgcccct tgttctgtga cttctacaac ccacatgggg gctgtgagtg gcactaccag 3960 ccctgcgggg caccctgcct aaaaacctgc cggaacccca gtgggcactg cctggtggac 4020 ctgcctggcc tggaaggctg ctacccgaag tgcccaccca gccagccctt cttcaatgag 4080 gaccagatga agtgcgtggc ccagtgtggc tgctacgaca aggacggaaa ctactatgac 4140 gtcggtgcaa gggtccccac agcggagaac tgccagagct gtaactgcac acccagtggc 4200 atccagtgcg ctcacagcct tgaggcctgc acctgcacct atgaggacag gacctacagc 4260 taccaggacg tcatctacaa caccaccgat gggcttggcg cctgcttgat cgccatctgc 4320 ggaagcaacg gcaccatcat caggaaggct gtggcatgtc ctggaactcc agccacaacg 4380 ccattcacct tcaccaccgc ctgggtcccc cactccacga caagcccggc cctcccggtc 4440 tccaccgtgt gtgtccgcga ggtctgccgc tggtccagct ggtacaatgg gcaccgccca 4500 gagcccggcc tgggaggcgg agactttgag acgtttgaaa acctgaggca gagagggtac 4560 caggtatgcc ctgtgctggc tgacatcgag tgccgggcgg cgcagcttcc cgacatgccg 4620 ctggaggagc tgggccagca ggtggactgt gaccgcatgc gggggctgat gtgcgccaac 4680 agccaacaga gtcccccgct ctgtcacgac tacgagctgc gggttctctg ctgcgaatac 4740 gtgccctgtg gcccctcccc ggccccaggc accagccctc agccctccct cagtgccagc 4800 acggagcctg ctgtgcctac cccaacccag accacagcaa ccgaaaagac caccctatgg 4860 gtgaccccga gcatccggtc gacggcggcc ctcacctcgc agactgggtc cagctcaggc 4920 cccgtgacgg tcaccccctc ggccccaggt accaccacct gccagccccg gtgtcagtgg 4980 acagagtggt ttgatgagga ctaccccaag tctgaacaac ttggagggga cgttgagtcc 5040 tacgataaga tcagggccgc tggagggcac ttatgccagc agcctaagga catagagtgc 5100 caggccgaga gcttccccaa ctggaccctg gcacaggtgg ggcagaaggt gcactgtgac 5160 gtccacttcg gcctggtgtg caggaactgg gagcaggagg gcgtcttcaa gatgtgctac 5220 aactacagga tccgggtcct ctgctgcagt gacgaccact gcaggggacg tgccacaacc 5280 ccgccaccga ccacagagct ggagacggcc accaccacca ccacccaggc cctgttctca 5340 acgccgcagc ctacgagtag cccggggctg accagggctc ccccggccag caccacagca 5400 gtccccaccc tctcagaagg actgacatcc cccagataca caagcaccct tggtacagcc 5460 accacgggag gccccacgac gcctgcaggc tccacagaac ccactgtccc aggggtggcc 5520 acatccaccc ttccaacacg ctcagccctt ccagggacga cggggagctt gggcacatgg 5580 cgcccctcac agccacccac gctggcccca acaacaatgg caacctccag agctcgcccg 5640 acaggcacag ccagcaccgc ttccaaagag ccgctgacca cgagcctggc gccaacactc 5700 acgagcgagc tgtccacctc tcaggccgag accagcacgc ccaggacaga gacgacaatg 5760 agccccttga ctaacaccac caccagccag ggcacgaccc gctgtcaacc gaagtgtgag 5820 tggacagagt ggtttgacgt ggacttccca acctcagggg ttgcaggcgg ggacatggaa 5880 acttttgaaa acatcagggc tgctgggggc aagatgtgct gggcaccaaa gagcatagag 5940 tgccgggcgg agaactaccc cgaggtaagc atcgaccagg tcgggcaggt gctgacctgc 6000 agcctggaga cggggctgac ctgcaagaac gaagaccaga caggcaggtt caacatgtgc 6060 ttcaactaca acgtgcgtgt gctttgctgt gacgactaca gccactgccc cagtacccca 6120 gccaccagct ccacggccac gccctcctca actccgggga cgacctggat cctcacaaag 6180 ccgaccacaa cagccactac gactgcgtcc actggatcca cggccacccc gacctccacc 6240 ctgagaacag ctccccctcc caaagtgctg accaccacgg ccaccacacc cacagtcacc 6300 agctccaaag ccactccctc ctccagtcca gggactgcaa ccgcccttcc agcactgaga 6360 agcacagcca ccacacccac agctaccagc gttacaccca tcccctcttc ctccctgggc 6420 accacctgga cccgcctatc acagaccacc acacccacgg ccaccatgtc cacagccaca 6480 ccctcctcca ctccagagac tgcccacacc tccacagtgc ttaccgccac ggccaccaca 6540 actggggcca ccggctctgt ggccaccccc tcctccaccc caggaacagc tcacactacc 6600 aaagtgccaa ctaccacaac cacgggcttc acagccaccc cctcctccag cccagggacg 6660 gcactcacgc ctccagtgtg gatcagcaca accaccacac ccacaaccag aggctccacg 6720 gtgaccccct cctccatccc ggggaccacc cacaccgcca cagtgctgac caccaccacc 6780 acaactgtgg ccactggttc tatggcaaca ccctcctcta gcacacagac cagtggtact 6840 cccccatcac tgaccaccac ggccactacg atcacggcca ccggctccac caccaacccc 6900 tcctcaactc ctgggacaac tcccatcccc ccagtgctga ccaccaccgc caccacacct 6960 gcagccacca gcaacacagt gactccctcc tctgccctag ggaccaccca cacaccccca 7020 gtgccgaaca ccatggccac cacacacggg cgatccctgc cccccagcag tccccacacg 7080 gtgcgcacag cctggacttc ggccacctcg ggcatcttgg gcaccaccca catcacagag 7140 ccttccacgg tgacttccca caccctagca gcaaccaccg gtaccaccca gcactcgact 7200 ccagcccttt ccagccctca ccctagcagc agaaccaccg agtcaccccc ttctccaggg 7260 acgaccaccc cgggccacac cacggccacc tccaggacca cagccacggc cacacccagc 7320 aagacccgca cctcgaccct gctgcccagc agccccacat cggcccccat aaccacggtg 7380 gtgaccatgg gctgtgagcc ccagtgtgcc tggtcagagt ggctggacta cagctacccc 7440 atgccggggc cctctggcgg ggactttgac acctactcca acatccgtgc ggccggaggg 7500 gccgtctgtg agcagcccct gggcctcgag tgccgtgccc aggcccagcc tggtgtcccc 7560 ctgcgggagt tgggccaggt cgtggaatgc agcctggact ttggcctggt ctgcaggaac 7620 cgtgagcagg tggggaagtt caagatgtgc ttcaactatg aaatccgtgt gttctgctgc 7680 aactacggcc actgccccag caccccggcc accagctcta cggccatgcc ctcctccact 7740 ccggggacga cctggatcct cacagagctg accacaacag ccactacgac tgagtccact 7800 ggatccacgg ccaccccgtc ctccacccca gggaccacct ggatcctcac agagccgagc 7860 actacagcca ccgtgacggt gcccaccgga tccacggcca ccgcctcctc cacccaggca 7920 actgctggca ccccacatgt gagcaccacg gccacgacac ccacagtcac cagctccaaa 7980 gccactccct tctccagtcc agggactgca accgcccttc cagcactgag aagcacagcc 8040 accacaccca cagctaccag ctttacagcc atcccctcct cctccctggg caccacctgg 8100 acccgcctat cacagaccac cacacccacg gccaccatgt ccacagccac accctcctcc 8160 actccagaga ctgtccacac ctccacagtg cttaccacca cggccaccac aaccggggcc 8220 accggctctg tggccacccc ctcctccacc ccaggaacag ctcacactac caaagtgctg 8280 actaccacaa ccacgggctt cacagccacc ccctcctcca gcccagggac ggcacgcacg 8340 cttccagtgt ggatcagcac aaccaccaca cccacaacca gaggttccac ggtgaccccc 8400 tcctccatcc cggggaccac ccacaccccc acagtgctga ccaccaccac cacaactgtg 8460 gccactggtt ctatggcaac accctcctct agcacacaga ccagtggtac tcccccatca 8520 ctgaccacca cggccactac gatcacggcc accggctcca ccaccaaccc ctcctcaact 8580 ccagggacaa cacctatccc cccagtgctg accaccaccg ccaccacacc tgcagccacc 8640 agcagcacag tgactccctc ctctgcccta gggaccaccc acacaccccc agtgccgaac 8700 accacggcca ccacacacgg gcgatccctg tcccccagca gtccccacac ggtgcgcaca 8760 gcctggactt cggccacctc aggcaccttg ggcaccaccc acatcacaga gccttccacg 8820 gggacttccc acaccccagc agcaaccacc ggtaccaccc agcactcgac tccagccctg 8880 tccagccctc accctagcag caggaccacc gagtcacccc cttctccagg gacgaccacc 8940 ccgggccaca ccagggccac ctccaggacc acggccacgg ccacacccag caagacccgc 9000 acctcgaccc tgctgcccag cagccccaca tcggccccaa taaccacggt ggtgaccatg 9060 ggctgtgagc cccagtgtgc ctggtcagag tggctggact acagctaccc catgccgggg 9120 ccctctggcg gggactttga cacctactcc aacatccgtg cggccggagg ggccgtctgt 9180 gagcagcccc tgggcctcga gtgccgtgcc caggcccagc ctggtgtccc cctgcgggag 9240 ttgggccagg tcgtggaatg cagcctggac tttggcctgg tctgcaggaa ccgtgagcag 9300 gtggggaagt tcaagatgtg cttcaactat gaaatccgtg tgttctgctg caactacggc 9360 cactgcccca gcaccccggc caccagctct acggccacgc cctcctccac tccagggacg 9420 acctggatcc tcacagagca gaccacagca gccactacga ccgcaaccac tggatccacg 9480 gccatcccgt cctccacccc gggaacagct ccccctccca aagtgctgac cagcacggcc 9540 accacaccca cagccaccag ttccaaagcc acttcctcct ccagtccaag gactgcaacc 9600 acccttccag tgctgacaag cacagccacc aaatccacag ctaccagctt tacacccatc 9660 ccctccttca cccttgggac caccgggacc ctcccagaac agaccaccac acccatggcc 9720 accatgtcca caatccaccc ctcctccact ccggagacca cccacacctc cacagtgctg 9780 accacgaagg ccaccacgac aagggccacc agttccatgt ccaccccctc ctccactccg 9840 gggacgacct ggatcctcac agagctgacc acagcagcca ctacaactgc agccactggc 9900 cccacggcca ccccgtcctc caccccaggg accacctgga tcctcacaga gcccagcact 9960 acagccaccg tgacggtgcc caccggatcc acggccaccg cctcctccac ccgggcaact 10020 gctggcaccc tcaaagtgct gaccagcacg gccaccacac ccacagtcat cagctccaga 10080 gccactccct cctccagtcc agggactgca accgcccttc cagcactgag aagcacagcc 10140 accacaccca cagctaccag cgttacagcc atcccctctt cctccctggg caccgcctgg 10200 acccgcctat cacagaccac cacacccacg gccaccatgt ccacagccac accctcctct 10260 actccagaga ctgtccacac ctccacagtg cttaccacca cgaccaccac aaccagggcc 10320 accggctctg tggccacccc ctcctccacc ccaggaacag ctcacactac caaagtgccg 10380 actaccacaa ccacgggctt cacagccacc ccctcctcca gcccagggac ggcactcacg 10440 cctccagtgt ggatcagcac aaccaccaca cccacaacca gaggctccac ggtgaccccc 10500 tcctccatcc cggggaccac ccacaccgcc acagtgctga ccaccaccac cacaactgtg 10560 gccactggtt ctatggcaac accctcctct agcacacaga ccagtgggac cacccacaca 10620 cccccagtgc cgaacaccac ggccaccaca cacgggcggt ccctgccccc cagcagtccc 10680 cacacggtgc gcacagcctg gacttcggcc acctcgggca tcttgggcac cacccacatc 10740 acagagcctt ccacggtgac ttcccacacc ccagcagcaa ccaccagtac cacccagcac 10800 tcgactccag ccctgtccag ccctcaccct agcagcagga ccaccgagtc acccccttct 10860 ccagggacga ccaccccggg ccacaccagg ggcacctcca ggaccacagc cacagccaca 10920 cccagcaaga cccgcacctc gaccctgctg cccagcagcc ccacatcggc ccccataacc 10980 acggtggtga ccacgggctg tgagccccag tgtgcctggt cagagtggct ggactacagc 11040 taccccatgc cggggccctc tggcggggac tttgacacct actccaacat ccgtgcggcc 11100 ggaggggcag tctgtgagca gcccctgggc ctcgagtgcc gtgcccaggc ccagcctggt 11160 gtccccctgc gggagttggg ccaggtcgtg gaatgcagcc tggactttgg cctggtctgc 11220 aggaaccgtg agcaggtggg gaagttcaag atgtgcttca actatgaaat ccgtgtgttc 11280 tgctgcaact acggccactg ccccagcacc ccggccacca gctctacggc cacgccctcc 11340 tcaactccgg ggacgacctg gatcctcaca aagctgacca caacagccac tacgactgag 11400 tccactggat ccacggccac cccgtcctcc accccaggga ccacctggat cctcacagag 11460 ccgagcacta cagccaccgt gacggtgccc accggatcca cggccaccgc ctcctccacc 11520 caggcaactg ctggcacccc acatgtgagc accacggcca cgacacccac agtcaccagc 11580 tccaaagcca ctcccttctc cagtccaggg actgcaaccg cccttccagc actgagaagc 11640 acagccacca cacccacagc taccagcttt acagccatcc cctcctcctc cctgggcacc 11700 acctggaccc gcctatcaca gaccaccaca cccacggcca ccatgtccac agccacaccc 11760 tcctccactc cagagactgc ccacacctcc acagtgctta ccaccacggc caccacaacc 11820 agggccaccg gctctgtggc caccccctct tccaccccag gaacagctca cactaccaaa 11880 gtgccgacta ccacaaccac gggcttcaca gtcaccccct cctccagccc agggacggca 11940 cgcacgcctc cagtgtggat cagcacaacc accacaccca caaccagtgg ctccacggtg 12000 accccctcct ccgtcccggg gaccacccac acccccacag tgctgaccac caccaccaca 12060 actgtggcca ctggttctat ggcaacaccc tcctctagca cacagaccag tggtactccc 12120 ccatcactga tcaccacggc cactacgatc acggccaccg gctccaccac caacccctcc 12180 tcaactccag ggacaacacc tatcccccca gtgctgacca ccaccgccac cacacctgca 12240 gccaccagca gcacagtgac tccctcctct gccctaggga ccacccacac acccccagtg 12300 ccgaacacca cggccaccac acacgggcga tccctgtccc ccagcagtcc ccacacggtg 12360 cgcacagcct ggacttcggc cacctcaggc accttgggca ccacccacat cacagagcct 12420 tccacgggga cttcccacac cccagcagca accaccggta ccacccagca ctcgactcca 12480 gccctgtcca gccctcaccc tagcagcagg accaccgagt cacccccttc cccagggacg 12540 accaccccgg gccacaccac ggccacctcc aggaccacgg ccacggccac acccagcaag 12600 acccgcacct cgaccctgct gcccagcagc cccacatcgg cccccataac cacggtggtg 12660 accacgggct gtgagcccca gtgtgcctgg tcagagtggc tggactacag ctaccccatg 12720 ccggggccct ctggcgggga ctttgacacc tactccaaca tccgtgcggc cggaggggcc 12780 gtctgtgagc agcccctggg cctcgagtgc cgtgcccagg cccagcctgg tgtccccctg 12840 ggggagttgg gccaggtcgt ggaatgcagc ctggactttg gcctggtctg caggaaccgt 12900 gagcaggtgg ggaagttcaa gatgtgcttc aactatgaaa tccgtgtgtt ctgctgcaac 12960 tacggccact gccccagcac cccggccacc agctctacgg ccatgccctc ctccactccg 13020 gggacgacct ggatcctcac agagctgacc acaacagcca ctacgactgc atccactgga 13080 tccacggcca ccccgtcctc caccccggga acagctcccc ctcccaaagt gctgaccagc 13140 ccggccacca cacccacagc caccagttcc aaagccactt cctcctccag tccaaggact 13200 gcaaccaccc ttccagtgct gacaagcaca gccaccaaat ccacagctac cagcgttaca 13260 cccatcccct cctccaccct tgggaccacc gggaccctcc cagaacagac caccacaccc 13320 gtggccacca tgtccacaat ccacccctcc tccactccgg agaccaccca cacctccaca 13380 gtgctgacca cgaaggccac cacgacaagg gccaccagtt ccacgtccac cccctcctcc 13440 actccgggga cgacctggat cctcacagag ctgaccacag cagccactac aactgcagcc 13500 actggcccca cggccacccc gtcctccacc ccagggacca cctggatcct cacagagctg 13560 accacaacag ccactacgac tgcgtccact ggatccacgg ccaccccgtc ctccacccca 13620 gggaccacct ggatcctcac agagccgagc actacagcca ccgtgacggt gcccaccgga 13680 tccacggcca ccgcctcctc cacccaggca actgctggca ccccacatgt gagcaccacg 13740 gccacgacac ccacagtcac cagctccaaa gccactccct cctccagtcc agggactgca 13800 actgcccttc cagcactgag aagcacagcc accacaccca cagctaccag ctttacagcc 13860 atcccctcct cctccctggg caccacctgg acccgcctat cacagaccac cacacccacg 13920 gccaccatgt ccacagccac accctcctcc actccagaga ctgtccacac ctccacagtg 13980 cttaccgcca cggccaccac aaccggggcc accggctctg tggccacccc ctcctccacc 14040 ccaggaacag ctcacactac caaagtgccg actaccacaa ccacgggctt cacagccacc 14100 ccctcctcca gcccagggac ggcactcacg cctccagtgt ggatcagcac aaccaccaca 14160 cccacaacca ccacacccac aaccagtggc tccacggtga ccccctcctc catcccgggg 14220 accacccaca ccgccagagt gctgaccacc accaccacaa ctgtggccac tggttctatg 14280 gcaacaccct cctctagcac acagaccagt ggtactcccc catcactgac caccacggcc 14340 actacgatca cggccaccgg ctccaccacc aacccctcct caactccagg gacaacaccc 14400 atcaccccag tgctgaccag cacggccacc acacccgcag ccaccagctc caaagccact 14460 tcctcctcca gtccaaggac tgcaaccacc cttccagtgc tgacaagcac agccacaaaa 14520 tccacagcta ccagctttac acccatcccc tcctccaccc tgtggaccac gtggaccgtc 14580 ccagcacaga ccaccacacc catgtccacc atgtccacaa tccacacctc ctctactcca 14640 gagaccaccc acacctccac agtgctgacc accacagcca ccatgacaag ggccaccaat 14700 tccacggcca caccctcctc cactctgggg acgacccgga tcctcactga gctgaccaca 14760 acagccacta caactgcagc cactggatcc acggccaccc tgtcctccac cccagggacc 14820 acctggatcc tcacagagcc gagcactata gccaccgtga tggtgcccac cggttccacg 14880 gccaccgcct cctccactct gggaacagct cacaccccca aagtggtgac caccatggcc 14940 actatgccca cagccactgc ctccacggtt cccagctcgt ccaccgtggg gaccacccgc 15000 acccctgcag tgctccccag cagcctgcca accttcagcg tgtccactgt gtcctcctca 15060 gtcctcacca ccctgagacc cactggcttc cccagctccc acttctctac tccctgcttc 15120 tgcagggcat ttggacagtt tttctcgccc ggggaagtca tctacaataa gaccgaccga 15180 gccggctgcc atttctacgc agtgtgcaat cagcactgtg acattgaccg cttccagggc 15240 gcctgtccca cctccccacc gccagtgtcc tccgccccgc tgtcctcgcc ctcccctgcc 15300 cctggctgtg acaatgccat ccctctccgg caggtgaatg agacctggac cctggagaac 15360 tgcacggtgg ccaggtgcgt gggtgacaac cgtgtcgtcc tgctggaccc aaagcctgtg 15420 gccaacgtca cctgcgtgaa caagcacctg cccatcaaag tgtcggaccc gagccagccc 15480 tgtgacttcc actatgagtg cgagtgcatc tgcagcatgt ggggcggctc ccactattcc 15540 acctttgacg gcacctctta caccttccgg ggcaactgca cctatgtcct catgagagag 15600 atccatgcac gctttgggaa tctcagcctc tacctggaca accactactg cacggcctct 15660 gccactgccg ctgccgcccg ctgcccccgc gccctcagca tccactacaa gtccatggat 15720 atcgtcctca ctgtcaccat ggtgcatggg aaggaggagg gcctgatcct gtttgaccaa 15780 attccggtga gcagcggttt cagcaagaac ggcgtgcttg tgtctgtgct ggggaccacc 15840 accatgcgtg tggacattcc tgccctgggc gtgagcgtca ccttcaatgg ccaagtcttc 15900 caggcccggc tgccctacag cctcttccac aacaacaccg agggccagtg cggcacctgc 15960 accaacaacc agagggacga ctgtctccag cgggacggaa ccactgccgc cagttgcaag 16020 gacatggcca agacgtggct ggtccccgac agcagaaagg atggctgctg ggccccgact 16080 ggcacacccc ccactgccag ccccgcagcc ccggtgtcta gcacacccac ccccacccca 16140 tgcccaccac agccgctctg tgatctgatg ctgagccagg tctttgctga gtgccacaac 16200 cttgtgcccc cgggcccatt cttcaacgcc tgcatcagcg accactgcag gggccgcctt 16260 gaggtgccct gccagagcct ggaggcttac gcagagctct gccgcgcccg gggagtgtgc 16320 agtgactggc gaggtgcaac cggtggcctg tgcgacctca cctgcccacc caccaaagtg 16380 tacaagccat gcggccccat acagcctgcc acctgcaact ctaggaacca gagcccacag 16440 ctggagggga tggcggaggg ctgcttctgc cctgaggacc agatcctctt caacgcacac 16500 atgggcatct gcgtgcaggc ctgcccctgc gtgggacccg atgggtttcc taaatttccc 16560 ggggagcggt gggtcagcaa ctgccagtcc tgcgtgtgtg acgagggttc agtgtcggtg 16620 cagtgcaagc ccctgccctg tgacgcccag ggtcagcccc cgccgtgcaa ccgtcccggc 16680 ttcgtaaccg tgaccaggcc ccgggccgag aacccctgct gccccgagac ggtgtgcgtg 16740 tgcaacacaa ccacctgccc ccagagcctg cctgtgtgcc cgccagggca ggagtccatc 16800 tgcacccagg aggagggcga ctgctgtccc accttccgct gcagacctca gctgtgttcg 16860 tacaatggca ccttctacgg ggttggtgca accttcccag gcgcccttcc ctgccacatg 16920 tgtacctgcc tctctgggga cacccaggac ccaacggtgc aatgtcagga ggatgcctgc 16980 aacaatacta cctgtcccca gggctttgag tacaagagag tggccgggca gtgctgtggg 17040 gagtgcgtcc agaccgcctg cctcacgccc gatggccagc cagtccagct gaatgaaacc 17100 tgggtcaaca gccatgtgga caactgcacc gtgtacctct gtgaggctga gggtggagtc 17160 catttgctga ccccacagcc tgcatcctgc ccagatgtgt ccagctgcag ggggagcctc 17220 aggaaaaccg gctgctgcta ctcctgtgag gaggactcct gtcaagtccg catcaacacg 17280 accatcctgt ggcaccaggg ctgcgagacc gaggtcaaca tcaccttctg cgagggctcc 17340 tgccccggag cgtccaagta ctcagcagag gcccaggcca tgcagcacca gtgcacctgc 17400 tgccaggaga ggcgggtcca cgaggagacg gtgcccttgc actgtcctaa cggctcagcc 17460 atcctgcaca cctacaccca cgtggatgag tgtggctgca cgcccttctg tgtccctgcg 17520 cccatggctc ccccacacac ccgtggcttc ccggcccagg aggccactgc tgtctgagaa 17580 cgttctgcct ccatccccat gctctgtcca cctggagcca ggatgtgcat tgtctgatca 17640 tgaaaacctt gggcctcctc tgcggagccc cccggcctgt gtgtggcacc ccgcgctccg 17700 tgctcctgct gcccaccccg tgggtgaaac cggccccaga agggtgaggg gccagcagga 17760 cccctttcgg gagggcgcca ctcaggagtc ctaccctggg agagcctgtg gcccaccttg 17820 gccttgcccc tccctgatgt cactggg 17847 <210> SEQ ID NO 26 <211> LENGTH: 3499 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 26 gccaagaagc ttgagagaag aaaaatttca gaaaaattgt ctcaatttga ctagaatatc 60 aatgaaccag gaaaactgaa gcaccttccc taaagaaaac ttgggtatac aattactcca 120 cagacagagc tgagggtttt ttacccaaat cagtcactgg attttgctgc ctgatacgtg 180 aatcttcttg gaatttttct catgtggatc taaggggaat gctttattat ggctgctgtt 240 gtccaacaga acgacctagt atttgaattt gctagtaacg tcatggagga tgaacgacag 300 cttggtgatc cagctatttt tcctgccgta attgtggaac atgttcctgg tgctgatatt 360 ctcaatagtt atgccggtct agcctgtgtg gaagagccca atgacatgat tactgagagt 420 tcactggatg ttgctgaaga agaaatcata gacgatgatg atgatgacat cacccttaca 480 gttgaagctt cttgtcatga cggggatgaa acaattgaaa ctattgaggc tgctgaggca 540 ctcctcaata tggattcccc tggccctatg ctggatgaaa aacgaataaa taataatata 600 tttagttcac ctgaagatga catggttgtt gccccagtca cccatgtgtc cgtcacatta 660 gatgggattc ctgaagtgat ggaaacacag caggtgcaag aaaaatatgc agactcaccg 720 ggagcctcat caccagaaca gcctaagagg aaaaaaggaa gaaaaactaa accaccacga 780 ccagattccc cagccactac gccaaatata tctgtgaaga agaaaaacaa agatggaaag 840 ggaaacacaa tttatctttg ggagttttta ctggcactgc tccaggacaa ggctacttgt 900 cctaaataca tcaagtggac ccagcgagag aaaggcattt ttaaattggt ggattctaaa 960 gcagtgtcca ggttgtgggg gaagcacaaa aacaaacctg atatgaatta tgagaccatg 1020 ggaagagcac tcaggtacta ttaccaaagg ggtattctgg caaaagtgga aggtcagcgc 1080 ttggtgtatc agtttaaaga aatgccaaaa gatcttatat atataaatga tgaggatcca 1140 agttccagca tagagtcttc agatccatca ctatcttcat cagccacttc aaataggaat 1200 caaaccagcc ggtcgagagt atcttcaagt ccaggggtaa aaggaggagc cactacagtt 1260 ctaaaaccag ggaattctaa agctgcaaaa cccaaagatc ctgtggaagt tgcacaacca 1320 tcagaagttt tgaggacagt gcagcccacg cagtctccat atcctaccca gctcttccgg 1380 actgttcatg tagtacagcc agtacaggct gtcccagagg gagaagcagc tagaaccagt 1440 accatgcagg atgaaacatt aaattcttcc gttcagagta ttaggactat acaggctcca 1500 acccaagttc cagtggttgt gtctcctagg aatcagcagt tgcatacagt aacactccaa 1560 acagtgccac tcacaacagt tatagccagc acagatccat cagcaggtac tggatctcag 1620 aagtttattt tacaagccat tccatcatca cagcccatga cagtactgaa agaaaatgtc 1680 atgctgcagt cacaaaaggc gggctctcct ccttcaattg tcttgggccc tgcccaggtt 1740 cagcaggtcc ttactagcaa tgttcagacc atttgcaatg gaaccgtcag tgtggcttcc 1800 tctccatcct tcagtgctac tgcacctgtg gtgacctttt ctcctcgcag ttcacagctg 1860 gttgctcacc cacctggcac tgtaatcact tcagttatca aaactcaaga aacaaaaact 1920 cttacacagg aagtagagaa aaaggaatct gaagatcatt tgaaagagaa cactgagaaa 1980 acggagcagc agccacagcc ttatgtgatg gtagtgtcca gttccaatgg atttacttct 2040 caggtagcta tgaaacaaaa cgaactgctg gaacccaact ctttttagtt aatataccaa 2100 agcttatgaa taattgtttg ttaattgaac attttcaatt atatgcagac tgactgattc 2160 taagataaat tctaaggagg tttctaattt tgtaattgtt aaaaatagag ttaattttga 2220 ctttgttaga tgagggagga aaactcaact gtttctcttt gttatctaaa tgtttcagaa 2280 ttcaatcgtg aaggaacagg cattttacac tatgaagaca ttcttttgag atttttattt 2340 cagttgctat atcataagca tttttaaagt ttcttttcta attttacatt gtattagatt 2400 ttctgattct tttgtaaata cagaacttaa atagaaggca acaggaaatt tatataggaa 2460 ctattttcat tccacttgtg taagttaagt cttgactctt tcaaatgcaa aaaacctatt 2520 ttatgctttg ttaaaattat ggtgtcactt agattgactt tagttgactg cactatataa 2580 tatagaacta tgaatatgta gaataacatg aaaaattgga ggtgctggtg gtatggctga 2640 ccctgtttca gaagcaggat agtataaaag catcagccta agaatggcac tcccactaac 2700 tagctatgta atcttgacct ctttgggctt tagttcctct cataaaagga agagatgtat 2760 tggattagac tagattatca ccactttctc ttctagttct aattttttta attctaatac 2820 ctatattttc aagttatgtc aattaaatca ttatcaggtt atttcctaat gtaagaatag 2880 ctaaaatgtt gcagagaaat aagtgaccca acaaaattta ttcatctgtt atgggtaaga 2940 tctgccataa attcttccta aataatttgt ttactaactc tttaggccac tgtgctttgc 3000 ggtccattag taaacttgtg ttgctaagtg ctaaacagaa tactgctatt ttgagagagt 3060 caagactctt tcttaagggc caagaaagca acttgagcct tgggctaatc tggctgagta 3120 gtcagttata aaagcataat tgctttatat tttggatcat tttttactgg gggcggactt 3180 ggggggggtt gcatacaaag ataacatata tatccaactt tctgaaatga aatgttttta 3240 gattactttt tcaactgtaa ataatgtaca tttaatgtca caagaaaaaa atgtcttctg 3300 caaattttct agtataacag aaatttttgt agatgaaaaa aatcattatg tttagaggtc 3360 taatgctatg ttttcatatt acagagtgaa tttgtattta aacaaaaatt taaattttgg 3420 aatcctctaa acatttttgt atctttaatt ggtttattat taaataaatc atataaaaat 3480 tctcaaaaaa aaaaaaaaa 3499 <210> SEQ ID NO 27 <211> LENGTH: 3302 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27 cggtgctgcc gccgttgccg ggagccgcgg agacaagtca ttacgttttc atttctcaca 60 actgggctga gcacaactga accatggggg aacacagtcc agacaacaac atcatctact 120 ttgaggcaga ggaagatgag ctgacccccg atgataaaat gctcaggttt gtggataaaa 180 acggactggt gccttcctca tctggaactg tttatgatag gaccactgtt cttattgagc 240 aggaccctgg cactttggag gatgaagatg acgacggaca gtgcggagaa cacttgcctt 300 ttctagtagg gggtgaagag ggctttcacc tgatagatca tgaagcaatg tcccagggtt 360 atgtgcagca cattatctca ccagatcaga ttcatttgac aataaaccct ggttccacac 420 ccatgccaag aaatattgaa ggtgcaaccc tcactctgca gtcggaatgt ccggaaacaa 480 aacgtaaaga agtaaagcgg taccaatgta cctttgaggg ctgtccccgc acctacagca 540 cagcaggcaa cctgcgaacc caccagaaga ctcaccgagg agagtacacc tttgtctgta 600 atcaggaggg ctgtggcaaa gccttcctta cctctcacag cctcaggatc cacgtgcgag 660 tgcacacgaa ggagaagcca tttgagtgtg acgtgcaggg ctgtgagaag gcattcaaca 720 cactgtacag gctgaaagca catcagaggc ttcacacagg gaaaacgttt aactgtgaat 780 ctgaaggctg cagcaaatac ttcaccacac tcagtgatct gaggaagcac attcgaactc 840 atacagggga aaagccattt cggtgcgatc acgatggctg tggaaaagca tttgcagcaa 900 gccaccacct taaaactcac gttcgtacac atactggtga aagacccttc ttctgcccca 960 gtaatggctg tgagaaaaca ttcagcactc aatacagtct caaaagtcac atgaaaggtc 1020 atgataacaa aggacactca tacaatgcac ttccacaaca caatggatca gaggatacaa 1080 atcactcact ttgtctaagt gacttgagcc ttctgtccac agattctgaa ttgcgagaaa 1140 attccagtac gacccagggc caggacctca gcacaatttc accagcaatc atctttgaat 1200 caatgttcca gaattcagat gatacggcaa ttcaggaaga tcctcaacag acagcttcct 1260 tgactgaaag ttttaatggt gatgcagagt cagtcagtga tgttccgcca tccacaggaa 1320 attcagcatc tttatctctt ccacttgtac tgcaacctgg cctctccgag ccaccccagc 1380 ctctactacc tgcctcagct ccgtctgctc ctccgcctgc tccctcccta ggacctggct 1440 cccagcaagc tgcatttggc aacccccctg ctctcttaca acctccagaa gtgcctgttc 1500 cccacagcac acagtttgct gctaatcatc aagagtttct tccgcacccc caggcaccgc 1560 agcccattgt accaggactt tctgttgttg ctggggcttc tgcatcagca gcggcagtgg 1620 catcagctgt ggcagcacca gccccaccac aaagtactac tgagcccctg ccagccatgg 1680 tccagactct gcccctgggt gccaactctg tcctaactaa taatcccaca ataaccatca 1740 ccccaactcc caacacagct atcctgcagt ccagcctagt catgggagaa cagaacttac 1800 aatggatatt aaatggtgcc accagttctc cacaaaacca agaacaaatt cagcaagcat 1860 ctaaagttga gaaggtgttt tttaccactg cagtaccagt agccagtagc ccagggagct 1920 ctgtccagca gattggcctc agtgttcctg tgatcatcat caaacaagaa gaggcatgtc 1980 agtgtcagtg tgcatgccgg gactctgcaa aggagcgggc atccagcagg agaaagggct 2040 gctcctcccc accccctcca gagccgagcc cccaggctcc tgatgggccc agcctgcagc 2100 tcccagcgca gactttctct tcagcccctg ttcccgggtc atcatcctct accttgccct 2160 cctcctgtga gcaaagccga caagcagaga ctccttcaga ccctcagaca gaaacattaa 2220 gtgccatgga tgtgtcagag tttctatccc tccagagcct ggacaccccg tccaatctga 2280 ttcccattga agcactactg cagggggagg aggagatggg cctcaccagc agcttctcca 2340 agtgaagggc ccatgtgtgc tcacctctgg gaaaagcggg tgagcaggag gcatgaggta 2400 caatgcctgc catcatgggt cagaaatttg aaggatgaag aaatctactg tttgaaatcc 2460 tcacctttca gacgtatttt ctttattcac atcccaggag catccatttt aaggaactat 2520 tctttggaaa aaaacaaaaa acaaaaaaaa caacaaaaaa agctaagtta taagtgaact 2580 gtttggctgc actgtatgtc acttttgctt gttgtcatgt gaacttggaa actaaggtta 2640 ctcgtgtgca taaaaattct aaatgaaagg gtgtggtttc catcaatctg atgctgccca 2700 tcgcttgcac tggggtcttt gtggatcggg caggagtttt cagtgtgttg ggtgttgctc 2760 cttcctatgt gtcttttgaa tctgaggctg acatttgctt ggaaggccag acccttgctc 2820 catcagagag ggcagtggca aaggccagtg aggcagctgt gagttggaca gggttcaggt 2880 gagatggtgt tgtcatttgt gcttagtgtt ggtggtgctc agggtggata acacgggtcg 2940 ttctgcagcc cgcttcagca caaataggca gcttaaggcc tggctcacag gctgtggggt 3000 tgatctggct ctgcagaggc cctaggcagc ttgttgactg ctgtctgttg atgacgtgtg 3060 tgcaaagcag gctctagcaa catgatcact gtccttgcct tcctggttct ttctctcggt 3120 tggttgccag ggcttgcaga tcgcagtgaa ttttccttgg ggaacatcgc tgttttgtcc 3180 tagagtgaac ttgtggctta tggccagtgc tgtttggtgg tctgccttct ttttaatggt 3240 attttcttcc tcagagcaga agggctgcat tttgcttatc agaagaaggt gcagatttaa 3300 gg 3302 <210> SEQ ID NO 28 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 28 ccttcctctc ctagcctaag gcgtgcaaac agagcgccac tgggaggctg aaacctttag 60 gccgatgctt gcttgcaagg tcaggcaagc tggattctgg tccccacctt tgcagagaga 120 acagcgatgt tgtgcgccca tttctcagat caaggaccgg cccatcttac tacctccaag 180 agtgcttttc tctctaataa gaaaacatct actttgaaac atctactggg cgagaccagg 240 agtgatggct cagcctgtaa ttctggaatt tcgggaggcc gaggcaggaa gattccttga 300 gcacaggagt tccagaccag cctgggcaat gtagcaagac gctgtctcta tttatacaat 360 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 390 <210> SEQ ID NO 29 <211> LENGTH: 2564 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 29 agatacacgg tttttaagaa agaacttcta accccactcc accgcccaac ggtcacgtga 60 cgcgcctgcg tcctcgcctc aaggtttttt ctggtcgcat attggctgtt aactcggcta 120 cggggtgtag cgaggtgcat tccggaagta ggtcctttga cttttgcttc ctctacggag 180 gcaagtaaca acccggcggt cgacgcttag cggaagttcg tcaagtcgca gttgcccccg 240 cacagcggat gtgggtcgcc tcttaggtga cgctgggaag tgcctgcaac cttcgccgct 300 gccttctggt tgaagcacta tggagggaga gaggaagaac aacaacaaac ggtggtattt 360 cactcgagaa cagctggaaa atagcccatc ccgtcgtttt ggcgtggacc cagataaaga 420 actttcttat cgccagcagg cggccaatct gcttcaggac atggggcagc gtcttaacgt 480 ctcacaattg actatcaaca ctgctatagt atacatgcat cgattctaca tgattcagtc 540 cttcacacag ttccctggaa attctgtggc tccagcagcc ttgtttctag cagctaaagt 600 ggaggagcag cccaaaaaat tggaacatgt catcaaggta gcacatactt gtctccatcc 660 tcaggaatcc cttcctgata ctagaagtga ggcttatttg caacaagttc aagatctggt 720 cattttagaa agcataattt tgcagacttt aggctttgaa ctaacaattg atcacccaca 780 tactcatgta gtaaagtgca ctcaacttgt tcgagcaagc aaggacttag cacagacttc 840 ttacttcatg gcaaccaaca gcctgcattt gaccacattt agcctgcagt acacacctcc 900 tgtggtggcc tgtgtctgca ttcacctggc ttgcaagtgg tccaattggg agatcccagt 960 ctcaactgac gggaagcact ggtgggagta tgttgacgcc actgtgacct tggaactttt 1020 agatgaactg acacatgagt ttctacagat tttggagaaa actcccaaca ggctcaaacg 1080 catttggaat tggagggcat gcgaggctgc caagaaaaca aaagcagatg accgaggaac 1140 agatgaaaag acttcagagc agacaatcct caatatgatt tcccagagct cttcagacac 1200 aaccattgca ggtttaatga gcatgtcaac ttctaccaca agtgcagtgc cttccctgcc 1260 agtctccgaa gagtcatcca gcaacttaac cagtgtggag atgttgccgg gcaagcgttg 1320 gctgtcctcc caaccttctt tcaaactaga acctactcag ggtcatcgga ctagtgagaa 1380 tttagcactt acaggagttg atcattcctt accacaggat ggttcaaatg catttatttc 1440 ccagaagcag aatagtaaga gtgtgccatc agctaaagtg tcactgaaag aataccgcgc 1500 gaagcatgca gaagaattgg ctgcccagaa gaggcaactg gagaacatgg aagccaatgt 1560 gaagtcacaa tatgcatatg ctgcccagaa tctcctttct catcatgata gccattcttc 1620 agtcattcta aaaatgccca tagagggttc agaaaacccc gagcggcctt ttctggaaaa 1680 ggctgacaaa acagctctca aaatgagaat cccagtggca ggtggagata aagctgcgtc 1740 ttcaaaacca gaggagataa aaatgcgcat aaaagtccat gctgcagctg ataagcacaa 1800 ttctgtagag gacagtgtta caaagagccg agagcacaaa gaaaagcaca agactcaccc 1860 atctaatcat catcatcatc ataatcacca ctcacacaag cactctcatt cccaacttcc 1920 agttggtact gggaacaaac gtcctggtga tccaaaacat agtagccaga caagcaactt 1980 agcacataaa acctatagct tgtctagttc tttttcctct tccagttcta ctcgtaaaag 2040 gggaccctct gaagagactg gaggggctgt gtttgatcat ccagccaaga ttgccaagag 2100 tactaaatcc tcttccctaa atttctcctt cccttcactt cctacaatgg gtcagatgcc 2160 tgggcatagc tcagacacaa gtggcctttc cttttcacag cccagctgta aaactcgtgt 2220 ccctcattcg aaactggata aagggcccac tggggccaat ggtcacaaca cgacccagac 2280 aatagactat caagacactg tgaatatgct tcactccctg ctcagtgccc agggtgttca 2340 gcccactcag cccactgcat ttgaatttgt tcgtccttat agtgactatc tgaatcctcg 2400 gtctggtgga atctcctcga gatctggcaa tacagacaaa ccccggccac cacctctgcc 2460 atcagaacct cctccaccac ttccacccct tcctaagtaa aaaaagaaaa agaagaggag 2520 aaaaaaactt ctttaaaaaa acacataatt tttctttttt tttt 2564 <210> SEQ ID NO 30 <211> LENGTH: 2948 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 30 gcgtgcgcaa tgggccacag aaccgccatg ccggaaccgc gcgggtcgtc gcagctgcgg 60 gtgaacgcgg cgtttgccgc gcggtacaac cgctaccggg agcgcgagga actgcagcgg 120 cgaatttgat ccccagcagg agcgggactt ttacaaaacg ctctccttgt tgaagaagaa 180 ggacccccgc atttatcaga aagatgccac cttctataac agaacagcat cgtcatcaga 240 cagtgaggag gacccagaag ccttggagaa gcagaagaaa gtgcggccca tgtacctgaa 300 ggactacgag aggaaggtta tcttggagaa ggcaggcaaa tatgttgatg aggagaactc 360 agacggggag acttccaatc acagactcca ggagacatcg tcgcaaagtt atgtggagga 420 acagaaacag ctcaaggaaa gcttccgggc atttgtggag gacagtgagg acgaggacgg 480 cgctggggag ggcggctcca gtttgctgca gaaacgtgcc aaaaccaggc aggagaaggc 540 ccaggaggag gccgactaca tcgagtggct gaagggacag aaagagattc ggaacccaga 600 ttccctgaag gaactgacgc atctcaagga atactggaac gaccctgagt tggatgaagg 660 ggagcggttc ctgcgggatt acatcctcaa caaacgctat gaggaggagg aagaggagga 720 ggaagatgaa gaggaaatgg aggaagagaa gggggtccac ggtcccccag tccagctggc 780 tgtggacgac tcctcagacg aaggggagct gtttctgaag aaacaggagg actttgaaca 840 gaagtacaat ttccgtttcg aggagccgga ctcagcatcg gtcaagacct acccacgcag 900 catcgcgtcc tccgtgcgcc gtaaggatga gcgcagaaag gagaagaggg aagagactcg 960 ggagcgaaag aagagggaga aagcaaagaa gcaggaagag ctcaagcagc tgaagaacct 1020 gaagaggaag gagattctgg ccaagctgga gaagctgcgg aaagtaacag gcaacgagat 1080 gctgggcctc gaggaggggg accttgaaga cgacttcgac cctgcccagc acgaccagct 1140 catgcagaag tgctttgggg acgagtacta cggggccgtg gaggaggaga agccacaatt 1200 tgaggaagaa gaagggcttg aagacgactg gaactgggac acgtgggacg ggcctgagca 1260 ggagggagac tggagccagc aggagctgca ctgtgaggac cccaacttca acatggacgc 1320 cgactacgac cccagccagc cgaggaagaa aaagcgcgag gcccccttga cgggcaagaa 1380 gaagcgcaag tcgcccttcg ccgcggccgt ggggcaggag aagcccgtgt tcgaacccgg 1440 ggacaagacg ttcgaggagt acctggatga gtattaccgg ctggactacg aggacatcat 1500 cgacgacctg ccctgtcgct tcaagtaccg cacagtggtg ccctgtgact ttggcctcag 1560 cactgaggag atcctcgctg ctgacgataa ggagctgaac cggtggtgct ccctaaagaa 1620 gacctgcatg tacaggtcag agcaggagga gctgcgggac aagcgggcgt acagccagaa 1680 ggcccagaac tcatggaaaa agcggcaggt cttcaagtca ctctgccgag aagaggcaga 1740 gacacctgcg gaagccacag ggaagccaca gagagatgaa gccggcccac agaggcagct 1800 gccagccctt gatggcagct tgatggggcc ggagagtccc ccagcacagg aagaggaagc 1860 ccctgtatca ccccacaaga agccagcccc ccagaagcgg aggagggcca agaaggcacg 1920 gctgctgggc cccactgtga tgcttggtgg atgcgagttc agccgccaga gactgcaggc 1980 ctttggcctc aaccccaaac ggctgcactt ccgccagctg ggccggcagc ggaggaaaca 2040 acaggggccc aagaacagct cctgagcacc agggagcagg caggggcctc aggctcctct 2100 cctcaaatca agccctggac aggtctcgca cccacaagta ctatctgctg cagagatcct 2160 ctcatctgtg gccaggcacg cctgtaatcc cagcactttg ggaggccgag gtgaaaggat 2220 cacttgagcc caggaattgg agaccagcgt gggcaactta gcgagactcc atctctacaa 2280 aatgtggtga cacatgcctg tagtcccagc tactcaggag gctggggaag gaagatcact 2340 taaggccatg agtttgaggc tacagagagc tatgattgca ccactgcact ccagcctggg 2400 caacaaagca agaccctgtc tcttgaaaaa aaaaaaaaaa ttaaaaaaca cgtgtagctg 2460 tgggtaagga agtcgtccca ttttatggat gtggaaactg aggctgactt aaacttcccg 2520 tgacttggag ctctcacctc gagacacctc ccagacccca catcccctca gaacgctgcg 2580 cccagccaca cccacgatca agttacacag ctttattggc ccccagcagc cacagttccc 2640 ccaagggggc tttgggacag ggagggcccg ggcgtccagt gcaaactaca gtacgtgagt 2700 caggccctga ggggggtgcc cggggtcctc cttccctacc ctgccaggag ggccccgctg 2760 gtgggagaca ggtgtatggg ctctgtgggc tctgtccctg gctgaatggc cccagactgg 2820 ttgcagctgg gcttgagggg ctgacaacag gaagtaccat catcactgcc agagctcaag 2880 atcccacacc cgacatgaca taaataaaaa aataaatagt gttgtatctt taaaaaaaaa 2940 aaaaaaaa 2948 <210> SEQ ID NO 31 <211> LENGTH: 3022 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 31 gcgtgcgcaa tgggccacag aaccgccatg ccggaaccgc gcgggtcgtc gcagctgcgg 60 gtgaacgcgg cgtttgccgc gcggtacaac cgctaccggg agcgcgagga actgcagcgg 120 ctgaaggatc gctacgggga ccgagacagc agcagcgact ccagctccga gtcggactca 180 agcgacgagc gcgtggaatt tgatccccag caggagcggg acttttacaa aacgctctcc 240 ttgttgaaga agaaggaccc ccgcatttat cagaaagatg ccaccttcta taacagaaca 300 gcatcgtcat cagacagtga ggaggaccca gaagccttgg agaagcagaa gaaagtgcgg 360 cccatgtacc tgaaggacta cgagaggaag gttatcttgg agaaggcagg caaatatgtt 420 gatgaggaga actcagacgg ggagacttcc aatcacagac tccaggagac atcgtcgcaa 480 agttatgtgg aggaacagaa acagctcaag gaaagcttcc gggcatttgt ggaggacagt 540 gaggacgagg acggcgctgg ggagggcggc tccagtttgc tgcagaaacg tgccaaaacc 600 aggcaggaga aggcccagga ggaggccgac tacatcgagt ggctgaaggg acagaaagag 660 attcggaacc cagattccct gaaggaactg acgcatctca aggaatactg gaacgaccct 720 gagttggatg aaggggagcg gttcctgcgg gattacatcc tcaacaaacg ctatgaggag 780 gaggaagagg aggaggaaga tgaagaggaa atggaggaag agaagggggt ccacggtccc 840 ccagtccagc tggctgtgga cgactcctca gacgaagggg agctgtttct gaagaaacag 900 gaggactttg aacagaagta caatttccgt ttcgaggagc cggactcagc atcggtcaag 960 acctacccac gcagcatcgc gtcctccgtg cgccgtaagg atgagcgcag aaaggagaag 1020 agggaagaga ctcgggagcg aaagaagagg gagaaagcaa agaagcagga agagctcaag 1080 cagctgaaga acctgaagag gaaggagatt ctggccaagc tggagaagct gcggaaagta 1140 acaggcaacg agatgctggg cctcgaggag ggggaccttg aagacgactt cgaccctgcc 1200 cagcacgacc agctcatgca gaagtgcttt ggggacgagt actacggggc cgtggaggag 1260 gagaagccac aatttgagga agaagaaggg cttgaagacg actggaactg ggacacgtgg 1320 gacgggcctg agcaggaggg agactggagc cagcaggagc tgcactgtga ggaccccaac 1380 ttcaacatgg acgccgacta cgaccccagc cagccgagga agaaaaagcg cgaggccccc 1440 ttgacgggca agaagaagcg caagtcgccc ttcgccgcgg ccgtggggca ggagaagccc 1500 gtgttcgaac ccggggacaa gacgttcgag gagtacctgg atgagtatta ccggctggac 1560 tacgaggaca tcatcgacga cctgccctgt cgcttcaagt accgcacagt ggtgccctgt 1620 gactttggcc tcagcactga ggagatcctc gctgctgacg ataaggagct gaaccggtgg 1680 tgctccctaa agaagacctg catgtacagg tcagagcagg aggagctgcg ggacaagcgg 1740 gcgtacagcc agaaggccca gaactcatgg aaaaagcggc aggtcttcaa gtcactctgc 1800 cgagaagagg cagagacacc tgcggaagcc acagggaagc cacagagaga tgaagccggc 1860 ccacagaggc agctgccagc ccttgatggc agcttgatgg ggccggagag tcccccagca 1920 caggaagagg aagcccctgt atcaccccac aagaagccag ccccccagaa gcggaggagg 1980 gccaagaagg cacggctgct gggccccact gtgatgcttg gtggatgcga gttcagccgc 2040 cagagactgc aggcctttgg cctcaacccc aaacggctgc acttccgcca gctgggccgg 2100 cagcggagga aacaacaggg gcccaagaac agctcctgag caccagggag caggcagggg 2160 cctcaggctc ctctcctcaa atcaagccct ggacaggtct cgcacccaca agtactatct 2220 gctgcagaga tcctctcatc tgtggccagg cacgcctgta atcccagcac tttgggaggc 2280 cgaggtgaaa ggatcacttg agcccaggaa ttggagacca gcgtgggcaa cttagcgaga 2340 ctccatctct acaaaatgtg gtgacacatg cctgtagtcc cagctactca ggaggctggg 2400 gaaggaagat cacttaaggc catgagtttg aggctacaga gagctatgat tgcaccactg 2460 cactccagcc tgggcaacaa agcaagaccc tgtctcttga aaaaaaaaaa aaaattaaaa 2520 aacacgtgta gctgtgggta aggaagtcgt cccattttat ggatgtggaa actgaggctg 2580 acttaaactt cccgtgactt ggagctctca cctcgagaca cctcccagac cccacatccc 2640 ctcagaacgc tgcgcccagc cacacccacg atcaagttac acagctttat tggcccccag 2700 cagccacagt tcccccaagg gggctttggg acagggaggg cccgggcgtc cagtgcaaac 2760 tacagtacgt gagtcaggcc ctgagggggg tgcccggggt cctccttccc taccctgcca 2820 ggagggcccc gctggtggga gacaggtgta tgggctctgt gggctctgtc cctggctgaa 2880 tggccccaga ctggttgcag ctgggcttga ggggctgaca acaggaagta ccatcatcac 2940 tgccagagct caagatccca cacccgacat gacataaata aaaaaataaa tagtgttgta 3000 tctttaaaaa aaaaaaaaaa aa 3022 <210> SEQ ID NO 32 <211> LENGTH: 2044 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 ctggacgagt ccgagcgcgt cacctcctca cgctgcggct gtcgcccgtg tcccgccggc 60 ccgttccgtg tcgccccgca gtgctgcggc cgccgcggca ccatggctgt gtttgtcgtg 120 ctcctggcgt tggtggcggg tgttttgggg aacgagttta gtatattaaa atcaccaggg 180 tctgttgttt tccgaaatgg aaattggcct ataccaggag agcggatccc agacgtggct 240 gcattgtcca tgggcttctc tgtgaaagaa gacctttctt ggccaggact cgcagtgggt 300 aacctgtttc atcgtcctcg ggctaccgtc atggtgatgg tgaagggagt gaacaaactg 360 gctctacccc caggcagtgt catttcgtac cctttggaga atgcagttcc ttttagtctt 420 gacagtgttg caaattccat tcactcctta ttttctgagg aaactcctgt tgttttgcag 480 ttggctccca gtgaggaaag agtgtatatg gtagggaagg caaactcagt gtttgaagac 540 ctttcagtca ccttgcgcca gctccgtaat cgcctgtttc aagaaaactc tgttctcagt 600 tcactccccc tcaattctct gagtaggaac aatgaagttg acctgctctt tctttctgaa 660 ctgcaagtgc tacatgatat ttcaagcttg ctgtctcgtc ataagcatct agccaaggat 720 cattctcctg atttatattc actggagctg gcaggtttgg atgaaattgg gaagcgttat 780 ggggaagact ctgaacaatt cagagatgct tctaagatcc ttgttgacgc tctgcaaaag 840 tttgcagatg acatgtacag tctttatggt gggaatgcag tggtagagtt agtcactgtc 900 aagtcatttg acacctccct cattaggaag acaaggacta tccttgaggc aaaacaagcg 960 aagaacccag caagtcccta taaccttgca tataagtata attttgaata ttccgtggtt 1020 ttcaacatgg tactttggat aatgatcgcc ttggccttgg ctgtgattat cacctcttac 1080 aatatttgga acatggatcc tggatatgat agcatcattt ataggatgac aaaccagaag 1140 attcgaatgg attgaatgtt acctgtgcca gaattagaaa agggggttgg aaattggctg 1200 ttttgttaaa atatatcttt tagtgtgctt taaagtagat agtatacttt acatttataa 1260 aaaaaaatca aattttgttc tttattttgt gtgtgcctgt gatgtttttc tagagtgaat 1320 tatagtattg acgtgaatcc cactgtggta tagattccat aatatgcttg aatattatga 1380 tatagccatt taataacatt gatttcattc tgtttaatga atttggaaat atgcactgaa 1440 agaaatgtaa aacatttaga atagctcgtg ttatggaaaa aagtgcactg aatttattag 1500 acaaacttac gaatgcttaa cttctttaca cagcataggt gaaaatcata tttgggctat 1560 tgtatactat gaacaatttg taaatgtctt aatttgatgt aaataactct gaaacaagag 1620 aaaaggtttt taacttagag tagccctaaa atatggatgt gcttatataa tcgcttagtt 1680 ttggaactgt atctgagtaa cagaggacag ctgtttttta accctcttct gcaagtttgt 1740 tgacctacat gggctaatat ggatactaaa aatactacat tgatctaaga agaaactagc 1800 cttgtggagt atatagatgc ttttcattat acacacaaaa atccctgagg gacattttga 1860 ggcatgaata taaaacattt ttatttcagt aacttttccc cctgtgtaag ttactatggt 1920 ttgtggtaca acttcattct atagaatatt aagtggaagt gggtgaattc tactttttat 1980 gttggagtgg accaatgtct atcaagagtg acaaataaag ttaatgatga ttccaaaaaa 2040 aaaa 2044 <210> SEQ ID NO 33 <211> LENGTH: 4000 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 cggccgcttt tttctcaaga tggcagattc ccactgaggc tgagggggcc gagctcgcgc 60 gccgcgttcc cttctccgtt gccatgaacc gcggacaccc cggccccgat ggcccccgtg 120 tacgaaggta tggcctcaca tgtgcaagtt ttctcccctc acacccttca atcaagtgcc 180 ttctgtagtg tgaagaaact aaaagtagag ccaagttcca actgggacat gactgggtac 240 ggctcccaca gcaaagtgta cagccagagc aagaacatac caccttctca gccagcctcc 300 acaaccgtca gcacctcctt gccggtccca aacccaagcc taccttacga gcagaccatc 360 gtcttcccag gaagcaccgg gcacatcgtg gtcacctcag caagcagcac ttctgtcacc 420 gggcaagtcc tcggcggacc acacaaccta atgcgtcgaa gcactgtgag cctccttgat 480 acctaccaaa aatgtggact caagcgtaag agcgaggaga tcgagaacac aagcagcgtg 540 cagatcatcg aggagcatcc acccatgatt cagaataatg caagcggggc cactgtcgcc 600 actgccacca cgtctactgc cacctccaaa aacagcggct ccaacagcga gggcgactat 660 cagctggtgc agcatgaggt gctgtgctcc atgaccaaca cctacgaggt cttagagttc 720 ttgggccgag ggacgtttgg acaagtggtc aagtgctgga aacggggcac caatgagatc 780 gtagccatca agatcctgaa gaaccgccca tcctatgccc gacaaggtca gattgaagtg 840 agcatcctgg cccggttgag cacggagagt gccgatgact ataacttcgt ccgggcctac 900 gaatgcttcc agcacaagaa ccacacgtgc ttggtcttcg agatgttgga gcagaacctc 960 tatgactttc tgaagcaaaa caagtttagc cccttgcccc tcaaatacat tcgcccagtt 1020 ctccagcagg tagccacagc cctgatgaaa ctcaaaagcc taggtcttat ccacgctgac 1080 ctcaaaccag aaaacatcat gctggtggat ccatctagac aaccatacag agtcaaggtc 1140 atcgactttg gttcagccag ccacgtctcc aaggctgtgt gctccaccta cttgcagtcc 1200 agatattaca gggcccctga gatcatcctt ggtttaccat tttgtgaggc aattgacatg 1260 tggtccctgg gctgtgttat tgcagaattg ttcctgggtt ggccgttata tccaggagct 1320 tcggagtatg atcagattcg gtatatttca caaacacagg gtttgcctgc tgaatattta 1380 ttaagcgccg ggacaaagac aactaggttt ttcaaccgtg acacggactc accatatcct 1440 ttgtggagac tgaagacacc agatgaccat gaagcagaga cagggattaa gtcaaaagaa 1500 gcaagaaagt acattttcaa ctgtttagat gatatggccc aggtgaacat gacgacagat 1560 ttggaaggga gcgacatgtt ggtagaaaag gctgaccggc gggagttcat tgacctgttg 1620 aagaagatgc tgaccattga tgctgacaag agaatcactc caatcgaaac cctgaaccat 1680 ccctttgtca ccatgacaca cttactcgat tttccccaca gcacacacgt caaatcatgt 1740 ttccagaaca tggagatctg caagcgtcgg gtgaatatgt atgacacggt gaaccagagc 1800 aaaacccctt tcatcacgca cgtggccccc agcacgtcca ccaacctgac catgaccttt 1860 aacaaccagc tgaccactgt ccacaaccag gctccctcct ctaccagtgc cactatttcc 1920 ttagccaatc ccgaagtctc catactaaac tacccatcta cactctacca gccctcagcg 1980 gcatccatgg ctgcagtggc ccagcggagc atgcccctgc agacaggaac agcccagatt 2040 tgtgcccggc ctgacccgtt ccagcaagct ctcatcgtgt gtccccccgg cttccaaggc 2100 ttgcaggcct ctccctctaa gcacgctggc tactcggtgc gaatggaaaa tgcagttccc 2160 atcgtcactc aagccccagg agctcagcct cttcagatcc aaccaggtct gcttgcccag 2220 caggcttggc caagtgggac ccagcagatc ctgcttcccc cagcatggca gcaactgact 2280 ggagtggcca cccacacatc agtgcagcat gccaccgtga ttcccgagac catggcaggc 2340 acccagcagc tggcggactg gagaaatacg catgctcacg gaagccatta taatcccatc 2400 atgcagcagc ctgcactatt gaccggtcat gtgacccttc cagcagcaca gcccttaaat 2460 gtgggtgtgg cccacgtgat gcggcagcag ccaaccagca ccacctcctc ccggaagagt 2520 aagcagcacc agtcatctgt gagaaatgtc tccacctgtg aggtgtcctc ctctcaggcc 2580 atcagctccc cacagcgatc caagcgtgtc aaggagaaca cacctccccg ctgtgccatg 2640 gtgcacagta gcccggcctg cagcacctcg gtcacctgtg ggtggggcga cgtggcctcc 2700 agcaccaccc gggaacggca gcggcagaca attgtcattc ccgacactcc cagccccacg 2760 gtcagcgtca tcaccatcag cagtgacacg gacgaggagg aggaacagaa acacgccccc 2820 accagcactg tctccaagca aagaaaaaac gtcatcagct gtgtcacagt ccacgactcc 2880 ccctactccg actcctccag caacaccagc ccctactccg tgcagcagcg tgctgggcac 2940 aacaatgcca atgcctttga caccaagggg agcctggaga atcactgcac ggggaacccc 3000 cgaaccatca tcgtgccacc cctgaaaacc caggccagcg aagtattggt ggagtgtgat 3060 agcctggtgc cagtcaacac cagtcaccac tcgtcctcct acaagtccaa gtcctccagc 3120 aacgtgacct ccaccagcgg tcactcttca gggagctcat ctggagccat cacctaccgg 3180 cagcagcggc cgggccccca cttccagcag cagcagccac tcaatctcag ccaggctcag 3240 cagcacatca ccacggaccg cactgggagc caccgaaggc agcaggccta catcactccc 3300 accatggccc aggctccgta ctccttcccg cacaacagcc ccagccacgg cactgtgcac 3360 ccgcatctgg ctgcagccgc tgccgctgcc cacctcccca cccagcccca cctctacacc 3420 tacactgcgc cggcggccct gggctccacc ggcaccgtgg cccacctggt ggcctcgcaa 3480 ggctctgcgc gccacaccgt gcagcacact gcctacccag ccagcatcgt ccaccaggtc 3540 cccgtgagca tgggcccccg ggtcctgccc tcgcccacca tccacccgag tcagtatcca 3600 gcccaatttg cccaccagac ctacatcagc gcctcgccag cctccaccgt ctacactgga 3660 tacccactga gccccgccaa ggtcaaccag tacccttaca tataaacact ggaggggagg 3720 gagggaggga gggagggaga gaatggcccg agggaggagg gagagaagga gggaggcgct 3780 cctgggaccg tgggcgctgg ccttttatac tgaagatgcc gcacacaaac aatgcaaacg 3840 gggcaggggc gggggggggg ggggcagagg gcagggggac gggtcgggac accagtgaaa 3900 cttgaaccgg gaagtgggag gacgtagagc agagaagaga acatttttaa aaggaaggga 3960 ttaaagaggg tgggaaatct atggttttta ttttaaaaaa 4000 <210> SEQ ID NO 34 <211> LENGTH: 5652 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 34 cttgctgtta atgaacttgg ttaaacatgg tcaagtgtat gtatgtatat attatcagta 60 ctggccttct ctatctaaga ggaatagcaa gaaatttaga gacattattt ggacattgat 120 ttctactaac tccactgaat tagattcagc cttcactttt tgggaaatgc acggacactg 180 ggaaagatga aatgaagaag ttttccagca tgatgttctt gtctttggag cttagcctta 240 cttaggtctt agaacaaaaa caagtcggta gttattagtt actgtatctc attttccaaa 300 acacacgttt ctttgttaca gtcatttaca catatttttg catgccacat ttttgctttt 360 gagcttttgc tgaatcacta aatgaccacc tttcatgttc ctaatgtatt aaaattatca 420 gaggattctt tgaggattaa atgtgtcagt aagggtatta ttttgaacaa tgcgtaaaag 480 gtgaaggcca gctgaagagg cctttttgtt gtgaacagaa taatatactg gaatctgagg 540 actgcactgt tatgaatgga ttatttggct atggaaagaa gttattttta ggcacagcat 600 ccctataagc cctgaagcta tgtgttttac aaactagaaa ttatgcacta aataaaaatt 660 accagatgtc agtctctgta tgtgccaaat ggcaaatgtg taatggttca gagcctggaa 720 gaaatgatgc ttatttcttt gccattcaaa ctcaaaaggg atagctgagg tagagtgctg 780 ttgaaaaaat tgcagtgttt ccagctaccc aaagatgtta cgaattgtta tctgaaaggc 840 tttcattctt tcccctcatg gctcgttgtg tgtttgtggc attacaaatg taacccacat 900 atttattcta atttattaca ttctttcctg aggctcctct tgttctttta aagggtcagc 960 agataactta ttttaagaat caacctggac acagtattct aacaaaggtc caatacagag 1020 ctaaataaat aataggagtc atagccagac acagtgactc acgcctgtaa tcccaacatt 1080 ttgggaggcc aaggcgggtg gattacctgg tggtgcatgc ctgtagtctc agctactcag 1140 gaggctgagg caggagaatc acttgaaccc gggacgcaga ggttacagtg aaccgagatt 1200 gcgccactgc actccagcct gggcaacaga gcgagacctc tatctcaaaa ataaataaat 1260 aaatacattt aaaatatata tatatatata tatatatata tatatatata tatatatata 1320 tatatatata tttatatata tttcgtgact tatatcttgc acataccagc atacctcatt 1380 aattttaatg taaccatcca ttggcttctc ttctctcctt agaaattcga gctcaactgg 1440 tagaacaaca aaaatgcctg gagcagcaaa cggagatgcg agttcagctt ctccaggatc 1500 tgcaagattt cttccgaaaa aaagctgaaa ttgagacgga atattcccgg aatctagaga 1560 agttagcaga aaggttcatg gcaaaaacaa gaagcactaa ggatcatcaa caatacaaga 1620 aagaccagaa cctgttgtct ccagtgaact gctggtattt gctcctgaac caagtaagga 1680 gagaaagcaa agaccatgca accttgagtg acatctatct gaacaatgtg attatgcggt 1740 tcatgcagat aagtgaggat tctaccagga tgtttaaaaa gagcaaagag attgcattcc 1800 aacttcatga ggatttaatg aaggttctta atgagcttta tacggtgatg aaaacatacc 1860 atatgtatca tgcagagagc atcagtgcag agagcaagct gaaagaggcc gaaaaacaag 1920 aggaaaagca aattgggaga tctggtgatc cagtcttcca tattcgacta gaggagagac 1980 atcaacggcg aagctctgta aagaaaattg aaaaaatgaa agaaaaaaga caagcaaaat 2040 attcagaaaa taagctaaaa tcaattaagg cacggaacga atatctccta acacttgaag 2100 ccaccaatgc ctcagttttc aagtactata ttcatgatct ttctgattta attgattgct 2160 gtgatcttgg ctaccatgca agtctgaaca gagccctaag aacatatctg tctgcggagt 2220 acaaccttga aacctccaga catgagggct tagacattat tgagaatgca gttgataatt 2280 tagagcccag gagcgataag cagagattca tggagatgta ccctgctgcg ttctgtccac 2340 caatgaagtt tgagtttcag tctcacatgg gtgatgaggt gtgccaggtc agtgcccagc 2400 agccagtcca ggcagagctc atgctcaggt accaacagtt gcagtcccgc cttgccacgc 2460 tcaaaatcga gaatgaagag gttaagaaaa cgactgaagc caccttgcag acgatacaag 2520 atatggtcac catcgaggac tatgatgttt ctgaatgctt ccagcacagt cgttccacag 2580 aatcagtgaa gtccactgtc tctgaaacct acctgagtaa acccagcatc gccaagagaa 2640 gagccaacca gcaggaaact gaacagttct acttcatgaa actcagagaa tatttggaag 2700 gcagtaatct catcacaaaa cttcaagcca aacatgactt gctgcagagg accctgggag 2760 aaggtcatag agctgaatat atgactacaa gccgaggacg aagaaactcg cacacaagac 2820 atcaggactc aggacaggtt attcccctca ttgtggaaag ctgtattcgg ttcatcaatc 2880 tctatggtct tcagcatcag gggattttca gagtgtctgg ttcccaggtg gaagtcaatg 2940 atattaaaaa ttcatttgag agaggtgaaa atcctttggc tgatgaccag agtaaccatg 3000 atattaactc agttgctggc gttctgaagc tctatttccg tgggctggaa aaccccctct 3060 ttcctaagga aagatttaac gatctgattt cttgtatcag aatagataat ctctatgaga 3120 gggcgcttca catccgcaaa ctcctcctga ctttgcccag gtcggtcctt atagtgatga 3180 ggtacctctt tgccttcctc aatcatctat cacagtacag cgatgagaat atgatggacc 3240 cttataacct ggccatttgc tttggcccaa cattgatgcc tgtcccagaa atacaggatc 3300 aagtgtcttg ccaggcacat gtgaatgaaa ttatcaaaac catcatcatc caccatgaga 3360 ctattttccc agatgctaaa gagctggatg gccctgttta tgagaaatgt atggctggag 3420 atgactattg cgacagccca tacagtgagc acggtacatt ggaggaagtg gaccaagatg 3480 ctggtacaga gccccacaca agtgaagatg aatgtgagcc aatagaagca atagccaagt 3540 ttgactatgt tgggcggtct gccagagaac tatccttcaa gaagggtgcc tccctgctgc 3600 tgtatcaccg tgcatctgag gactggtggg aaggcaggca caacgggatt gacgggctgg 3660 tgcctcacca gtatatagtg gtgcaggata tggatgatac gttttcagac actctgagcc 3720 aaaaagccga cagtgaggcc agcagtgggc cagtcacgga agacaagtcc tcatccaagg 3780 acatgaactc cccgacagac cgtcatcctg acggctattt agccaggcaa cgaaaaagag 3840 gagagccacc ccctccagta aggcgtcctg gcaggaccag tgatggccat tgcccgctcc 3900 accctccaca tgccctttct aactcctcag ttgacctagg gtccccaagc cttgccagtc 3960 acccccgggg cctgctgcag aaccgtggcc tcaacaatga cagtcctgag cggaggcgca 4020 ggcctggcca tggcagcctg accaacatca gccggcacga ctccctcaag aagatcgaca 4080 gccctcccat tagaaggtcc acgtcatcag ggcaatacac gggcttcaat gaccacaagc 4140 cactggaccc agagacaatt gctcaggata ttgaagaaac gatgaacaca gctttgaatg 4200 aactccgaga actggagaga cagagcacag caaagcatgc ccctgatgtg gtgctggata 4260 ccctggagca agtgaaaaac tctcccaccc ctgccacttc cacggaatct ctcagccctt 4320 tgcacaacgt tgccctcagg agctccgagc ctcagattcg acgtagcacg agctcctcca 4380 gtgacacaat gagtactttc aagcctatgg tggcacccag aatgggcgtg cagctgaagc 4440 ctccagccct taggccaaaa cctgctgttc ttccaaaaac aaatcctacc ataggacctg 4500 ccccacctcc ccagggtcca acagacaagt catgcacaat gtaaaaacca gccaagcaag 4560 gccataaagg gaggtgactt aaaaaagaaa atggattagt gacaaaagtc actgatccat 4620 aactttcctt agttttgtgc ttataactgg agatcttttg gcttttctat gttgtcgaat 4680 gtaatgtctg agactagcta aattaacacg ggcatttgta ttttgtaatt tttttaaata 4740 actggacata tgtcatttta aggacaatag aaacacttag acttacttga aaatccaatg 4800 ctgcaccact tgtaatgaag gcaacaccgc tctccacatt gtacagagct tcaggtttaa 4860 tgtagcccag ctgagtcaga aaggttgtga cctgaaggca gaagaacccg aatgccacac 4920 ctcattggag tatagccagt gttggtctgt ggcacttggg ctgaaaggtg ataatggcat 4980 tgcgtggtag ctgacaatga gcaccttcgg ttccatgtgg agcggggttt agctcatgca 5040 aaagacttgc aattgtctcc atgggacgat cccagtggga ctgtcagccc acagctcgag 5100 tgggttggat gcttgcctct ttcctaacag ttatttcccc gggtccagct taaagactcg 5160 atggaaggag gtagaacctc tgctgttact gcttgaactt aacctgggaa aggagaggaa 5220 gacaccatct ccaaagctat taatgtcact ccttttgcga gcatgattag gccccggaga 5280 tttccaagtc cccccatcta cacttacaaa cgattagaag ggtttaattt taaagacttt 5340 ctggttacac tactccacga actcctccaa agatccgtta ttcaataact gcctagaaaa 5400 tgtttccatc tcctctaaat ccctgtgttc tcctctgtgg aaatgaaggc agcaagaagc 5460 acctgaggcc ttggttcatg cagtgttctc ttttgactaa atcacctagg ttcctttaaa 5520 catgctacaa agcccaggca tggtggtgca cacctgtact cccagctact cgggtggttt 5580 acacaggagg atggctttgg gcctagtagt tcgagtccag cctgggcagc atagtgtgag 5640 accctgtctc tt 5652 <210> SEQ ID NO 35 <211> LENGTH: 2920 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 35 tgtcaaccag cactttttaa gatgaactgt aaccaactag cttctcacat gcttctcata 60 tggtaagagt taattttagc tcatgaaact tttggttctg tgaaacacct gctgaacaga 120 ctcctgggaa gggggtctgt gggagtcgac atttatacaa ccttccaggt gattctgagc 180 ttatcagagc tggagaggca cttgctaccc aggggcttgg tgtggaacgt gagatgccaa 240 agccaaattc aggcctctca gctcaaggca ccctgaagca cagctagtca ctccagcaca 300 tgttgaagct gtgcatgttt acttcatgtt gaactgttca tgttttattt ttggaacact 360 ggggattggc aaaaaaaaaa aaaacccatg tgaataaagc cttctagggc accactgtgc 420 cgattgtgaa ccacacgtgg acaaaacaag ccgcgcttga tagcaactac ctacatgacc 480 agcactcccc tggatgctga tgctgccatg cgagacggga cgttggcgca gcagcatgcc 540 agccacccat tgcttctcct gcttgccaac tcaaccgtgc tgctccctca gacaccatca 600 cttgcgcctc ccaagcaatg gaagccctgg cgatgctctc atgagcccct cactccagca 660 gagcccctga ccaagccagg ggagcaggac ttttccagcc aaggacacaa cggactggtg 720 gctgtgagta cctccccact tgatcccact tcactggccc tgggcgtgtg gctctcagca 780 gcctgggaag gagtgtgaag aagcaggtgg gataagggcc ttgagagaga aggaaaaggc 840 agcctagtcg atgctctctg ctctccagtg ctgactgggg gctgggtcga atgctcatct 900 gcagccagct gtggacatca caggctcctt tcctcccctt cccctaatgg ggaaaggtgg 960 tttccccatg gcctgtgagg gagtcaggga gcttccagaa acaagctgac aaggtgggga 1020 agcatgtaac caacacagca tgagagcagg cagcgtacct gcagagactg ggggtgaaca 1080 ccgccgtctt cgagaggcgc catgtgatcg ggggtgcagc tgtcactgag gagatcatcc 1140 cagggtttaa gttctcccgc gcgtcctacc tgctcagcct gctgaggccg cagatttaca 1200 ctgatctgga gctgaagaaa catgggctga ggcttcatct tcgaaacccc tactccttca 1260 cccccatgct ggaagagggt gcaggcagca aggtgcccag gtgccttctg ctgggcacag 1320 acatggcaga aaaccagaag cagatcgccc agttctccca gaaggatgcc caggtctttc 1380 ccaaatatga ggagttcatg catcgcttgg cattagccat tgaccctctg ctggatgcgg 1440 cccccgtgga catggcggcc ttccagcatg gctccttgct gcaaaggatg aggtcgctct 1500 ccaccctcaa gcccctgctg aaggcaggcc gcatcctggg agcccagctt ccccgatatt 1560 atgaggtcct cacagctccc attaccaagg tgctggatca gtggttcgag tctgagcctt 1620 taaaagccac tctagccaca gatgcagtga ttggagccat gacaagtccc cacactccgg 1680 ggagtgggta tgtgctgctg caccatgtga tggggggcct ggagggaatg cagggggcct 1740 ggggctacgt ccaggggggc atgggtgccc tctctgatgc gatcgcaagc tcagccacca 1800 cacatggagc aagcatcttc actgaaaaga cagtggcgaa ggtgcaggtg aacagtgaag 1860 gctgtgttca aggagttgtg ctggaagatg gcacagaggt gagaagcaaa atggtgctgt 1920 ccaacacatc accgcagatc accttcctga agctgacgcc acaggagtgg cttcctgagg 1980 agttcctgga gagaatctct cagctggaca cccggtcgcc tgtcaccaag atcaatggta 2040 agaggcacac cacattgcag cactgtctcc tttgacccat ctgagtgaga aacctccagg 2100 ctgggggcag ctgaactcag tcatcatctc cattcccgga cctccagcct gtgtccccct 2160 gcagcctggt cagaagtggc cgtagacagg ctgcccagct tcctggcggc ccccaatgct 2220 cccaggggcc agccgctgcc ccatcaccaa tgctccatcc acctgaactg tgaagacacc 2280 ctcctccttc atcaggcctt tgaagatgcc atggatggcc tgccttccca cagtgtttga 2340 ttgcatcgag gtctatgccc ctggcttcaa ggactctgtg gttggcagag acatcctcac 2400 accaccagat ttggagagaa tcttcgggct tcctggaggg aacatattcc actgcgccat 2460 gtccctggac cagctctact tcgcccgccc cgtgcccctg cattctggct accgctgccc 2520 tctccagggc ctgtatctct gtggaagtgg ggctcatcct ggaggaggtg tgatgggagc 2580 tgctgggcga aatgcagcac atgtggcctt tagggacctc aagagcatgt gaccctgaac 2640 cagctctgac ccaggaagaa gactccaccc ctgaattcca agtgctccat tggatcagct 2700 tcccaggaag ttcagcttcg ggttagtaca taaggccacc acaatgctca agaaattatt 2760 ttagaaaaaa cgtacgagtt acatttagtg caagttgacc ttatgcccat gcctccatac 2820 atggactggt tctgttttat taaaactaat atttcataca aaaaaaaaaa aaaaaaaaaa 2880 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2920 <210> SEQ ID NO 36 <211> LENGTH: 2129 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 cgtaatggcg gacacaggca gggcgagcgc ggctgggggc gtagcgcgct gagggggtcc 60 ggccgtttgg cagcccgcga ggcggtccgc gggagcacac tctgtgcgga gactgggcgg 120 ccggccgacc cttcctgtcg ctgacggcga ctgcgggagg ccaggttgtt tttcaccatt 180 cagaacattg cctgaagcag gtccaccatg ccgttagtaa cgaggaacat cgagccaagg 240 cacctgtgcc gtcagacgtt gcctagcgtt agaagcgagc tggaatgcgt gaccaacatc 300 accctggcaa atgtcatccg acagctgggc agcctgagta aatatgcaga ggacattttt 360 ggagagctct ttactcaggc aaataccttt gcctctcggg taagctccct tgctgagagg 420 gtcgaccgac tacaggttaa agtcactcag ctggatccca aggaagaaga agtgtcactg 480 caaggaatca acacccgaaa agccttcaga agttccacca ttcaagacca gaagcttttt 540 gacagaaact ctctcccagt gcctgtctta gaaacataca atacctgtga tactcctccc 600 cctctcaaca atcttacccc ttacagggac gatggaaaag aggcactcaa attctacaca 660 gacccttcat acttctttga tctttggaag gagaagatgc tgcaggacac caaggatatc 720 atgaaagaga agagaaagca taggaaagaa aagaaagata atccaaatcg agggaatgta 780 aacccacgta aaatcaagac acgtaaggaa gagtgggaga aaatgaagat ggggcaagaa 840 tttgtggagt ccaaagaaaa gctggggact tctgggtatc cacccacttt ggtgtaccag 900 aatggcagca ttggctgtgt tgaaaacgtg gatgcaagta gctatccgcc accaccacag 960 tcagactctg cttcttcacc ttctccttcc ttctccgagg acaacttgcc tcctccacca 1020 gcagaattca gttacccagt ggacaaccaa agaggatctg gtttggctgg acccaaaaga 1080 tccagtgtgg tcagcccaag ccatccacca ccagctcctc ctctaggctc tccaccaggc 1140 cctaaacccg ggtttgctcc accacctgcc cctccgccac ctccgcctcc aatgataggc 1200 atcccacctc caccaccgcc tgtaggattt gggtctccag ggacgcctcc accaccctca 1260 cccccatctt tcccacctca ccctgatttt gctgcccctc cacctcctcc tccaccacca 1320 gcagctgact acccaactct gccaccacct cccttgtccc agccaacagg aggagcacct 1380 cctcctcccc ctcctcctcc tcctccgggg ccccctcctc cccctttcac tggtgcagat 1440 ggccaacctg ctataccacc accgctttct gataccacca agcccaagtc ctccttgcct 1500 gccgtgagcg atgcccgtag cgacctgctt tcagccatcc gtcaaggttt tcagctgcgc 1560 agggttgagg agcagcggga acaagagaag cgggatgttg tgggcaatga cgtggccacc 1620 atcttgtctc gtcgcattgc tgttgagtac agtgactcag aagatgactc ctctgaattt 1680 gatgaggacg actggtccga ttaactcttt ctgcctgctg cccaccttct ttttctttcc 1740 ttcctacctg ccttctttga tgccaacccc aacagacccg tagggggaga aaagggagga 1800 aaaaagtaat tttaaggggc caaagctttc cctgaagcaa ccaaagatat atccaagtgc 1860 ttcctccaag tcaacatgta tttcctctcc ccattttcag gccctgtggg gctcctgagg 1920 ttcagtagct gggatgttcc ctctttcctt caagtgcctg ttgcatattg aaaggaagga 1980 gaaatcccaa agcagattcc tttgatcggg tttctgttgg agatggggct tcccttagga 2040 gccatattca actacagcct tctaaaacct gtgccctcag ccactttaaa aaaaaaaaaa 2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2129 <210> SEQ ID NO 37 <211> LENGTH: 4878 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 37 gtccgccatt tgcaaggggc ccggagcggg atcgcggcac ctgccgagcg ggtcgccgcc 60 tctgccgcgg tccttggacc ccgccgccgc cctggcctgg gagcttgccc cgccgcagcg 120 gccggcagcg cggcgctccg cgggcggcag gcacgggccc cgggccccct cacggcgccc 180 agccgcgggc ctcccgaggc aaaagcccgt gggccgccgc gatggccctc aagatggtga 240 agggcagcat cgaccgcatg ttcgacaaga atctgcagga cttggtccgc ggcatccgta 300 accacaagga ggacgaggca aaatacatat ctcagtgcat tgatgagatc aagcaggagc 360 tgaagcagga caacatagcg gtgaaggcga acgcggtctg caagctgacg tatttacaga 420 tgttgggata cgacatcagc tgggccgcct tcaacatcat agaagtgatg agtgcctcca 480 agttcacctt caagcgaatt ggctacctcg ctgcttccca gagctttcac gaaggcaccg 540 acgtcatcat gctgaccacc aatcagatcc gtaaggactt gagcagcccc agccagtacg 600 acacaggtgt tgcactgacg ggtctgtcct gcttcgtcac cccagacctt gccagagacc 660 tggcaaatga catcatgaca ctgatgtcac acaccaagcc ctacatcagg aagaaggctg 720 tgctgatcat gtacaaggtg ttcctgaagt accccgagtc gctgcgccct gcctttcccc 780 ggctgaagga gaagctggag gaccccgacc ccggggttca gtcggctgcc gtcaatgtca 840 tctgcgagct ggccagacgc aaccctaaga actacctgtc cctggccccg ctctttttca 900 agctgatgac gtcctccacc aacaactggg tcctcatcaa gatcatcaag ctgttcggtg 960 ctcttactcc tttggaaccg cggctgggca agaagctgat cgagcccctc accaatctca 1020 tccacagcac gtctgccatg tctctcctct atgaatgtgt gaacaccgtg attgcagtgc 1080 tcatctcgct gtcctccggc atgcccaacc acagcgccag catccagctt tgtgttcaga 1140 aattaaggat attgatcgag gactccgatc agaacttgaa gtacctgggg ctgctggcaa 1200 tgtccaagat cctgaagacc caccccaagt ccgtgcagtc ccacaaggac ctcatcctgc 1260 agtgcctgga cgacaaggac gagtccatcc ggctgcgggc cctggacctg ctctatggga 1320 tggtgtccaa gaagaacctg atggagatcg tgaagaagct gatgacccac gtagacaagg 1380 cagagggtac cacctaccgt gacgagctgc tcaccaagat cattgacatc tgcagccagt 1440 ccaactacca gtacatcacc aacttcgagt ggtacatcag catcctggtg gagctgaccc 1500 ggctggaggg cacacggcac ggccacctca tcgccgccca aatgctggac gtggccatcc 1560 gcgtgaaggc catccgcaag ttcgccgtgt cccagatgtc tgcgctgctt gacagtgcac 1620 acctgctggc cagcagcacc cagcggaacg ggatctgtga ggtgctgtac gctgccgcct 1680 ggatctgcgg ggagttctca gagcatctgc aggaaccaca ccacactttg gaggccatgc 1740 tgcggcccag agtcaccacg ctgccaggcc acatccaggc cgtgtatgtg cagaacgtgg 1800 tcaagctcta cgcctccatc ctgcagcaga aggagcaggc cggggaggca gagggcgctc 1860 aggccgtcac ccagctcatg gtggaccggc tgccccagtt tgtgcagagc gcagacctgg 1920 aggtgcagga gcgggcgtcc tgcatcctgc agctggtcaa gcacatccag aagcttcagg 1980 ccaaggacgt gcctgtggca gaggaggtca gcgctctctt tgctggggag ctgaacccag 2040 tggcccccaa ggcccagaag aaggttccag tccccgaagg cctggacctg gacgcctgga 2100 tcaatgagcc actctcggac agcgagtcag aggacgagag gcccagggcc gtcttccacg 2160 aggaggagca gcggcgtccc aagcaccggc cgtcggaggc ggacgaggaa gagctggctc 2220 ggcgccgaga ggcccggaag caggagcagg ccaacaaccc cttctacatc aagagctcgc 2280 catcgccaca gaagcggtac caggacaccc cgggcgtgga gcacattccc gtggtgcaga 2340 ttgacctctc cgtccccttg aaggttccag ggctgcctat gtcagatcag tatgtgaagc 2400 tggaggagga gcggcggcac cggcagaagc tggagaagga caagaggagg aaaaagagga 2460 aggagaagga gaagaagggc aagcgccgcc acagctcgct gcccacggag agcgacgagg 2520 acatcgcccc tgcccagcag gtggacatcg tcacagagga gatgcctgag aatgctctgc 2580 ccagcgacga ggatgacaaa gaccccaacg acccctacag ggctctggat attgacctgg 2640 ataagccctt agccgacagc gagaaactgc ctattcagaa acacagaaac accgagacct 2700 caaaatcccc tgagaaggac gttcccatgg tagaaaagaa gagcaagaaa cccaagaaga 2760 aagagaaaaa acacaaagag aaagagagag acaaggagaa gaagaaggag aaggagaaga 2820 agaaatctcc caagcctaag aagaagaagc acaggaagga gaaggaggag cggaccaaag 2880 gcaagaagaa gtccaagaag cagcctccag gcagcgagga ggcagcgggg gagccggtgc 2940 agaatggcgc gccagaggag gagcagctcc cgcctgagtc cagctactcc ctcctcgctg 3000 aaaattccta tgttaaaatg acctgtgaca tccggggcag tctgcaggag gacagccagg 3060 tcactgtggc catcgtgctg gagaacagga gcagcagcat cctcaagggc atggagctca 3120 gcgtgctgga ctcactcaat gccaggatgg cccggccgca gggctcctcc gtccacgatg 3180 gcgtccccgt gcctttccag ctgcccccag gcgtctccaa cgaagcccag tatgtgttca 3240 ccatccagag catcgtcatg gcgcagaagc tcaaggggac cctgtccttc attgccaaga 3300 atgacgaggg tgcgacccac gagaagctgg acttcaggct gcacttcagc tgcagctcct 3360 acttgatcac cactccctgc tacagtgacg cctttgctaa gttgctggag tctggggact 3420 tgagcatgag ctcaatcaaa gtcgatggca ttcggatgtc cttccagaat cttctggcga 3480 agatctgttt tcaccaccat ttttccgttg tggagcgagt ggactcctgc gcctccatgt 3540 acagccgctc catccagggc caccatgtct gcctcctggt gaaaaaggtg agaactctgt 3600 ctcagtcgac gggaagtgca gtgactccac gctactgagc aacttgttag aagagatgaa 3660 ggcgacgctg gccaagtgtt gagagctgcc tgcgagcccc gcaccacccc gcggagcacg 3720 tacccaggga ccgcagccct gacgtgtctc gcctctcctc agtcgtgtgt actgtaccca 3780 agcctgagtg ttaatttaac tctatgttgt ccgccgtgta gacatccgag gtcatttgtt 3840 gcgttgaatt atctgaccat ccttttttac tgtgactctt cccattctct ttggcaagaa 3900 gtccccttct cgcccccaaa ccagcaaggg actcccccac ctgggtctgt gccctgcccc 3960 gcgctggggg ccgagtcctt gaatgtggct tcaggggctc ctgtcctggg ccagggcctg 4020 atgggcacca cgtgaggggc acttggtgga cagggcgggg ctgacgtggc ctcctctggg 4080 gtcgcctgct tttgacccaa aggtcctgac ggttgcgtcc gggggagggg aaggaagggc 4140 cgctgtcgcc aaggttttct ctcccagaac ccacagtggg aaagcggtct tgccaggcgt 4200 tgtccattgt cagtgtgctc gtgggctggt gactgggtct tgggatccca ggccacgcgc 4260 cagccaggct gtgggcaggg cggggccagg gacgccaaag agaggttgca gtcagaaccg 4320 tggacggggt gggttgaggc ctctctgcca cccgtcttcc tggtcagcag aagtgcatct 4380 cggcttgggt ttggggtggt ccgcatcccc tgcttgccac tatgcgcacc aaggtttccc 4440 cacatccttc ccagcaccct taggaaggcc caggcagggc ctggaagcag cggacctggg 4500 ctgttctgtg ttgaaggagt gtgcccagtg cccttgggca ggacctgtga gagccacctc 4560 acaggcagag cccccaccag gcagggcaag gagactccgc tcactcccca cggccagcgt 4620 gggcacagga ctgacccttc ttcagagata atgacatttt atcttctcct tttgatgaaa 4680 actgtcactt tagcatgtaa tccattacag aatcccatgc agtgattcca ggatttgaaa 4740 ttgtatgatg tgttacataa gaatttattt gctatcgaca ttcccgtata aagagagaga 4800 catatcacgc tgctgtcatg attttgtgtc aagatgatcc aataaagttg taaaacaggc 4860 atttccaaaa aaaaaaaa 4878 <210> SEQ ID NO 38 <211> LENGTH: 964 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 38 gagtgccgta gcgcccggct cctgcagacg ctcggcctcc gctcattcct gaccccgcag 60 tgggcgcgat ggcggaggct gtactgaggg tcgcccggcg gcagctgagc cagcgcggcg 120 ggtctggagc ccccatcctc ctgcggcaga tgttcgagcc tgtgagctgc accttcacgt 180 acctgctggg tgacggagag tcccgggagg ccgttctgat cgacccagtc ctggaaacag 240 cgcctcggga tgcccagctg atcaaggagc tggggctgcg gctgctctat gctgtgaata 300 cccactgcca cgcggaccac attacaggct cggggctgct ccgttccctc ctccctggct 360 gccagtctgt catctcccgc cttagtgggg cccaggctga cttacacatt gaggatggag 420 actccatccg cttcgggcgc ttcgcgttgg agaccagggc cagccctggc cacaccccag 480 gctgtgtcac cttcgtcctg aatgaccaca gcatggcctt cactggagat gccctgttga 540 tccgtgggtg tgggcggaca gacttccagc aaggctgtgc caagaccttg taccactcgg 600 tccatgaaaa gatcttcaca cttccaggag actgtctgat ctaccctgct cacgattacc 660 atgggttcac agtgtccacc gtggaggagg agaggactct gaaccctcgg ctcaccctca 720 gctgtgagga gtttgtcaaa atcatgggca acctgaactt gcctaaacct cagcagatag 780 actttgctgt tccagccaac atgcgctgtg gggtgcagac acccactgcc tgatctcact 840 tctgtcagat gctcccatcc actattaatg cactaggtgg gaggagaggg cggcaatgac 900 actgcacctc tcctttccca ccgcattccc tggagctccc taaataaaac tttttttaac 960 gtga 964 <210> SEQ ID NO 39 <211> LENGTH: 3384 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 39 atggcccccg gggagaagat caaagccaaa atcaagaaga atctgcccgt gacgggccct 60 caggcgccga ccattaaaga gctgatgcgg tggtactgcc tcaacaccaa cacccatggc 120 tgtcgccgca tcgtggtgtc ccgcggccgt ctgcgccgcc tcctctggat cgggttcaca 180 ctgactgccg tggccctcat cctctggcag tgcgccctcc tcgtcttctc cttctatact 240 gtctcagttt ccatcaaagt ccacttccgg aagctggatt ttcctgcagt caccatctgc 300 aacatcaacc cctacaagta cagcaccgtt cgccaccttc tagctgactt ggaacaggag 360 accagagagg ccctgaagtc cctgtatggc tttccagagt cccggaagcg ccgagaggcg 420 gagtcctgga actccgtctc agagggaaag cagcctagat tctcccaccg gattccgctg 480 ctgatctttg atcaggatga gaagggcaag gccagggact tcttcacagg gaggaagcgg 540 aaagtcggcg gtagcatcat tcacaaggct tcaaatgtca tgcacatcga gtccaagcaa 600 gtggtgggat tccaactgtg ctcaaatgac acctccgact gtgccaccta caccttcagc 660 tcgggaatca atgccattca ggagtggtat aagctacact acatgaacat catggcacag 720 gtgcctctgg agaagaaaat caacatgagc tattctgctg aggagctgct ggtgacctgc 780 ttctttgatg gagtgtcctg tgatgccagg aatttcacgc ttttccacca cccgatgcat 840 gggaattgct atactttcaa caacagagaa aatgagacca ttctcagcac ctccatgggg 900 ggcagcgaat atgggctgca agtcattttg tacataaacg aagaggaata caacccattc 960 ctcgtgtcct ccactggagc taaggtgatc atccatcggc aggatgagta tccctccgtc 1020 gaagatgtgg gaacagagat tgagacaaca atggtcacct ctataggaat gcacctgaca 1080 gagtccttca agctgagtga gccctccagt cagtgcacgg agggcgggag tgacgtgcca 1140 atcaggaaca tctacaacgc tgcctactcg ctccagatct gccttcattc atgcttccag 1200 acaaagatgg tggagaaatg tgggtgtgcc cagtacagcc agcctctacc tcctgcagcc 1260 aactactgca actaccagca gcaccccaac tggatgtatt gttactacca actgcatcga 1320 gcctttgtcc aggaagagct gggctgccag tctgtgtgca aggaagcctg ccgctttaaa 1380 gagtggacac taaccacaag cctggcacaa tggccatctg tggtttcgga gaagtggttg 1440 ctgcctgttc tcacttggga ccaaggccgg caagtaaaca aaaagctcaa caagacagac 1500 ttggccaaac tcttgatatt ctacaaagac ctgaaccaga gatccatcat ggagagccca 1560 gccaacagta ttgagatgct tctgtccaac ttcggcggtc agctgggcct gtggatgagc 1620 tgctctgttg tctgcgtcat cgagatcatc gaggtcttct tcattgactt cttctctatc 1680 attgcccgcc gccagtggca gaaagccaag gagtggtggg cctggaaaca ggctccccca 1740 tgtccagaag ctccccgtag cccacagggc caggacaatc cagccctgga tatagacgat 1800 gacctaccca ctttcaactc tgctttgcac ctgcctccag ccctaggaac ccaagtgccc 1860 ggcacaccgc cccccaaata caataccttg cgcttggaga gggccttttc caaccagctc 1920 acagataccc agatgctgga tgagctctga ggcagggttg agaagacaga tctagtcagg 1980 accaccagcc atggtctaag gacatggatc gggtgccccc agacgtgtgc acaggggacc 2040 ctctgcccca ctctgggctt ttcagatact ctgaccaaaa agcctgcttt aaaccgcaag 2100 atggggcctg ggcatgcgca ggaggagcca tcgggtacta cgcagcaaca ctcacaactg 2160 tccaggctga gataaatccc gggacctgaa ctattagcac gtcactagag actgggagcc 2220 gaggcagtgg tgctggccca agtgaaggcc agagtgagga ctgatgcagc tctttacggg 2280 tcttgagagg gaaggactct tccaaagccc caaagccgag ggtttcaccc acactgccag 2340 cctgggttgg ggcccaagga tgtgaccttg agtgtcaagg ctggacagct actgccagat 2400 gccaaagata ggagaaagtg ccagccctga agctggagcc gcttgtgaat aaactgttct 2460 tcatcattga cactggagaa aggtgtcctc catgccctca ggcagcagag aactggccca 2520 gagcccttgg agtgttggtg gagatcagag tgccgtggtg gaggtctggg actatgtcag 2580 agtgtcctca ctttggggca tgggtggctc caggagatgg atttagttat tcaattttgt 2640 ggatgaataa attgaggcac agaaagatta agttaccggc ccaaggtgac acagtgagga 2700 ggtggcagag ctaggatttg accccagaca atctgacttc atgattgtgg catccaattc 2760 gtgtctgtgc ctcaatttgt gcaaacgact gtgtcacttt gcttggggag ggggagcatc 2820 ccacccacat gccctgggca ggtgacccaa gacagagctg acccctccac caccaaaggc 2880 ctgtctctca ccaacaagcc aactgctcac agatgaccca cttcatacca cattcacatc 2940 tggccacctg actccagcta tcaggtatta agtcccgggc agcgataagc ccccccacaa 3000 cagtgtgtta gctctgtctt agcaacctga taggttagca taggggctgc aaatgttgtt 3060 ccgccacacc aaatccctgt ttttgtccat gaactaagaa ttttatttta ttttattttt 3120 tattttttgt agaaatagga tctcactatg ttgcccaggc tgttcttgaa ctcctggcct 3180 caaatgatct tcccacttca gcctcccaaa gtgcagggat tacaggcaca agccaccgtg 3240 cccagccaag aatttttatt tttgctttta aatacccaaa gaagaagatt ctgtgactca 3300 tggaaatgat atgagattcg aattccagtg tctataaata aagttttatt ggtacacagc 3360 cccaaaaaaa aaaaaaaaaa aaaa 3384 <210> SEQ ID NO 40 <211> LENGTH: 6280 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 ggtgaaggac ctgggcagcc tcaatgggac gtttgtgaat gacatgcgca tcccggacca 60 gaagtacgtc acgctgaagc tcaacgatgt catccgcttt ggctacgatt ccaacatgta 120 tgtgctggag cgtgtgcagc accgagtccc ggaggaggca ctcaagcatg aaaagtacac 180 cagccagctg caggtgagcg tgaagggttt ggcgcccaag aggagcgagg cactgccgga 240 acacacacca tactgcgagg cctcgaaccc caggccggag aagggggacc ggagaccagg 300 aacagaggca gcctcttacc gcacacccct gtatgggcag ccctcctggt ggggtgagga 360 cgatggtagc acgctgcctg atgcccagcg ccagggagag ccctacccag agcgccccaa 420 gggacccgtg cagcaggacg gggagctcca cggcttccgc gcccctgctg agcctcaggg 480 ctgctcgttc cggcgggagc ccagctactt cgagatcccc acgaaggaga ccccgcagcc 540 gtcgcagccc cccgaggtgc cggcacacga gatgcccacg aaggatgcag aggcaggtgg 600 gggcggagcg gcccctgtgg tgcagagcca cgcctccttc accatcgagt ttgatgactg 660 cagccctggc aagatgaaga tcaaggacca tatcaccaag ttttccctgc gccagcggcg 720 gcccccgggc aaggaggcca cacctggcga gatggtgtcg gctgagacca aggtggccga 780 ctggctggtg cagaatgacc cgagcctgct gcaccgggtt ggccctgggg atgaccgcca 840 cagcaccaag agcgacctgc ctgtccacac ccgcaccctg aagggccaca agcacgagga 900 cggcacgcag agtgactcag aggaccccct ggccaaggcg gcctcggccg ctggggtgcc 960 cttggaggcc agcggggggc aggtgcggct gcagaggcag atcaagcggg acccccagga 1020 gctactacat aaccagcagg cctttgtcat cgagttcttc gacgaggaca cgccccgaaa 1080 gaagcgctcc cagtccttca cgcacagccc gtccggggac cccaaggccg acaagcgccg 1140 tggcccaacg ccggccgata gggaccgccc cagtgtccca gccccagtcc aggcaggggg 1200 ccgcagctcg gggccacaga gggccggctc gctcaagcgg gagaagacag aggaacggct 1260 gggcagcccc tcgcccgcct cccgaacccc tgcccgcccc ttcggaagcg tggggcgccg 1320 ctcccgcctg gcccaggact tcatggccca gtgtctgcgg gagagctccc cggccgcccg 1380 gcccagcccc gagaaggttc ctccggtgct gcccgctccc ctgacacccc atgggaccag 1440 ccccgtgggc cccccgaccc caccgcccgc ccccacggac ccccagctga ccaaggcacg 1500 gaaacaggag gaggatgaca gcctcagtga cgcagggaca tacaccatcg agaccgaggc 1560 gcaggacacg gaggtggagg aggctcggaa gatgatcgac caggtctttg gggtgttgga 1620 gtcccctgaa ctctccaggg catcttcggc cacctttcgc ccagtcatca gaggggacag 1680 agatgagtct gatgacgggg gcgtggccca gcggatggcg ctactgcagg agtttgcctc 1740 ccggccactg ggtgcggccc cccaggcgga gcaccagggc ctcccggtgc cgggctcccc 1800 tgggggtcag aagtgggtgt cccgctgggc cagcctggct gacagctact cagacccggg 1860 cctcacagag gatggcctgg gacgtagagg cggggagccg gaggggtccc tgcctgtgcg 1920 catgcggcga cggctccctc agctgcccag tgagagggct gacagccctg cgggcccaga 1980 gagcagcagg aggagtgggc ctgggccacc ggagctggac agtgagcagc ccagccgcct 2040 cttcggccag gaggagttgg atcctgacag cctcagcgat gccagtgggt cggacggggg 2100 ccgaggcccc gagccagggg tggagccaca ggacagcaga cgcaggagcc cccaggaggg 2160 gcccacgtgg agcaggggtc ggcgctcacc aagggccccc ggggagccaa ctcccgcctc 2220 tttcttcatt ggggaccaga atggggacgc tgtgttatct aggaaactgc ttgcggctcc 2280 aggggatggg gagggcctag ggcagacagc ccagcccagc cccccagcac gggatggcgt 2340 ctatgtcagt gccaatggga gaatggtcat ccagctacgg cctggacggt ccccagaacc 2400 cgacggccct gccccagcct ttctccggca agagagcttc actaaggagc cagccagtgg 2460 tcccccagcg cccggcaagc ccccccacat ctccagccac ccgcttctac aggacctggc 2520 cgctacccgg gccgcacgca tggacttcca ctcccaggac acccacctga tcttgaagga 2580 gacggagacg gccctggcgg ccctggaggc ccgactcctc tctaattctg tggatgccga 2640 gtgtgagggg ggcagcaccc cgaggccgcc ggaggacgcc ctgtctgggg actcggacgt 2700 ggacacagcc agcaccgtca gcctgcgtag tggcaagagc gggcccagcc ccacaacccc 2760 ccagcctctg cgggcacaga aggagatgtc gccatccccg ccagctgcac aggacccggg 2820 aggcaccgcc ctggtcagtg cccgtgagca gtcctcagag aggcagcatc acccacttgg 2880 cccgacggac atgggccgtg gagagccggt acggcgctca gccataaggc gtggccacag 2940 gccccgaggg tccctggatt ggcccagtga ggagcgtggc cctgtcctcg cccacctacc 3000 cagctcagat gtgatggcct ccaaccacga aacccctgag gccaccgggg caggacggct 3060 aggttctcgc cggaaaccag cggccccacc gccatcccca gctgcccggg aggagcagag 3120 ccgtagctca gccagctccc agaaggggcc gcaggccttg acccgctcca acagcctgtc 3180 cacccctcgc cccacacggg cctcccggct gaggcgggcc cggctggggg acgcttcaga 3240 cactgaggct gcggatggtg agcgggggtc cctgggcaac cctgagcccg tgggccggcc 3300 agctgctgag caggccaaga agctgtcacg cctggacatc ctggccatgc cccggaagcg 3360 ggccggctcc ttcacaggga ctagtgaccc cgaggcagcc cctgcccgca ccagcttctc 3420 tggccgcagt gtggagttgt gctgtgccag ccgcaagccc accatggccg aagcacgggc 3480 tgtctccagg aaggctgcca acacagccac caccacgggt ccccgccagc ccttcagcag 3540 ggcccgctcg ggcagtgccc gatacacctc caccactcag accccgaggg ctggcagctc 3600 cagccgggct cgttcccggg cccccggccc ccgggacacg gacgacgatg aggaggagcc 3660 tgacccttat ggtttcatcg tgcagacggc agagattgcg gagattgcca ggctgagcca 3720 gacgctggtg aaggacgtgg ccatcctagc ccaggagatc cacgatgtgg ctggggacgg 3780 tgacacactg ggctcctcgg agcctgccca cagcgcctcc ctcagcaaca tgcccagcac 3840 ccccgcctcg accatctctg cccgggagga gctggtgcag cgcatccccg aggccagcct 3900 caacttccag aaggtgccgc ccggctcgct gaactctcgg gactttgacc agaacatgaa 3960 cgacagctgt gaggacgccc tggccaacaa gacgcggcct cggaaccgag aggaggtgat 4020 cttcgataac ctgatgctga acccggtgtc ccagctgtcg caggccatcc gtgagaacac 4080 agagcacctt gccgagaaga tgaagatcct ctttcagaac acagggagag cttgggagga 4140 cctggaagcc aggatcaacg ccgagaacga ggtgcccatc ctgaagacat ctaacaagga 4200 aatcagctcc atcctgaagg aactgaggcg ggtgcagaaa cagctggaag ttatcaatgc 4260 catcgtggac cccagtggga gcctggacct gctcacagga aacaggagct tggccagctc 4320 tgcacagccg gggctgggga agggccgcgt ggctgcccag agcccaccct cacccgcctc 4380 agccgaggcc ctgctgccag ccctgcccct gaggaatttc ccacagcggg ccagctgtgg 4440 gcctcccagc ctcccggacc ccaccttcct ccctgatgcc gagaggttcc tgatctaggc 4500 cccagacctg gccaggccag cctccctgtg cgtgtgcgtc tctgccttcc gtccgccgca 4560 cacccgcctg cctggccgca ggtggttctc cctgaagacc cccacatgtg ccatatccct 4620 gtgggcgggt gcctcccacg cccttgcccc ctcgtcagct cccagccagc accctactca 4680 ccctgtccag ccccatggcc acccccaccc ctgcctcgcc ccctacaggc ctctgggccc 4740 agctcctggc caggctgctg ccaaggtcaa gccctcaagg gcattacccc gcctcctctt 4800 catcactgtt atttttgtct ttagctttaa aggaaagagt tgttggtgcc attgcaggtg 4860 ccccctccag gcctgactgg ctccgccagg cactaacctg ccataaccct ttgtgctggc 4920 ctgcggccag gcagaggaag agaggtcgac tgtggggtca tttggtgcca aacatggagg 4980 tgggcaggct cacctgttcc tgggactgtc tgagatggca gggcacttgc cctggtggct 5040 cccacctgac cccaggcctt ttataggcag gagccccact gcttccagcc tctggtgcca 5100 acacagttgc caaacccatt gagcttgggg ctgccccgtg gaggcctcct gggtatggac 5160 caggggcttg ttgagagctg agccatgcac acaggtgcag acacccccca actcccatgc 5220 acacggctag tccaggcgcc tccacgctgc accgtgagga ctgcagggca tgtccccgtg 5280 aggggctatg ggcctctgta ggtgggcttc caaggtcctg ggtgcagccg ggtgcatggc 5340 agcccttctg gcgggggtga gcgcacgacc aaagtcactg gaagccgggt ttccggaagc 5400 tcgcagcttg gcctgcacca cacgccctcc ccttttggct tcacgccatc aggcctcaag 5460 tgggcatggg ggcagggacg ggcccaggaa ctgttgtttt ctcaggattc tttcagctgg 5520 gaacatggca ggtgagcaga gcttggtgcc tctgccgtgg cccctgctgg ggcagcccgt 5580 gttgccggag cctctaagcc aaagagcccg ttggccgtgg ttggtggggg tggacgtggg 5640 ggtgtcccac ctggaccaga ctggcgtggg tgagctccac accctgcctg gcaatggtat 5700 gagagtcgga cctggacagg gccagctgct gggggagcgg cactggggac tggaggctgg 5760 aagcgggtgg tgtgtgtccc ctgtttactt ttagctgagc tggggttggg tgtacgggtt 5820 ctgttcctct gagccctgcg gcccacctga tgtttacgtg tgtgtgtgag ggggggcggg 5880 ggtggcaggt gtccccccct ggtccccgcc ccaagagcct gctgtctgta tggaggaggt 5940 gctagcccgg tccaccgggc tgctgcccac ccctgcatgc cccagttgcc caccccgcct 6000 gcccctggac atgaagtggt cacgcttcat ccacggctcc ttcccacccc tcggcagtgg 6060 ctgtgcaatg ttttaagttc acaagttcct gctcctcccc acactgagct cctttgttcc 6120 tccccctcca gcctttgcct gggaactggt ccttgtttgc cgggcttctc ggagggttca 6180 ctgtacattc gttctcaggt ggtcttgtgg ctgtctttcg gaaaatggtt attttatatg 6240 atttgtcatg gaatttgttc taataaatca ttcttctatc 6280 <210> SEQ ID NO 41 <211> LENGTH: 2782 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 41 gcgacgccga gtttcactct ggctgccttc tcctgagagt cggagccaca gccagagccc 60 tgcccaggcc gagccggagc tgcagcccga gcgcggtggt gccctcagcc ccgtcctctt 120 gtcctcctca gcctcggtgc cttggaattt gtgtcgctga gtcagcaagc ctttcagatt 180 tgcccggttt ttgttgtttg tggtttgtat caagatggga actcaaacaa gtcattcctc 240 ctaaggagct ggtgtcttca tccagaaggg acagtttgtg ccagctctcc agagagaaaa 300 ggatctggta ctgttctgga gtggcctgta gcagacactg aaccaccagc cagctgcatt 360 tgttgtcctg gaagtcattg ccaactctgc cagtcacact ggggtcccca aagaagtcaa 420 gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg 480 tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg 540 caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc 600 tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag 660 ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc 720 tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc 780 accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc 840 gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac 900 tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac 960 aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttttgccgc 1020 agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc 1080 cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg 1140 tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc 1200 ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc 1260 tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct 1320 cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag 1380 cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc 1440 tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga 1500 gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg 1560 tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt 1620 cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag 1680 ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag 1740 gactgcatca tctgcatgga gaagctgtcc gcagcgtctg gatacagcga tgtgactgac 1800 agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac 1860 ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc 1920 tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta 1980 ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac 2040 agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc 2100 agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag 2160 ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg 2220 ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac 2280 attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct 2340 gcccaggggg tgaccgagga ctgcctggag cagcagtgac ctcgcacccc agcacgcccg 2400 cctctggtgg ccaccccgct gccccatggc tggctgggtg gccaggcagg aagtgcccag 2460 cccgagaggc tgggaggttt gttgagggtg tggggtgtgc cccacctgaa gccggggctc 2520 cccctgcctg cctctctctc ctcctcccct ctgggaattg ggcagccctg ggcagttgta 2580 ctcatggggg cttaggatgc agctacctca gtgcgcaggg cccgtctgtc ctctgggggc 2640 tgcttcgggc ccgcggtgct cggggcctgg tgtggggcga gtagagactt ccccagcctg 2700 gacgggcgtg ggttctgggt cagcttcttt tacctcaatt ttgtttgcaa taaatgctct 2760 atagccaaaa aaaaaaaaaa aa 2782 <210> SEQ ID NO 42 <211> LENGTH: 2124 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 42 gctccgcaat catcttcttt accctggagc tgctgctgct gctgctgctt ttgcttttgg 60 ggctgagttt aataagcgag cgagcgagca agcgagcgcg gggggaaaaa ggcagagaat 120 gtccgccatc taccctccgc tcctgggcgc gctctcattc atagcagcct cttcatgaat 180 tacagctgag ggggggcgga ggaggggggg gtaccacaca acaccccagc aaacctccgg 240 gcccccaggc atggctagct cgtgtgccgt gcaggtgaag ctggagctgg ggcaccgcgc 300 ccaggtgagg aaaaaaccca ccgtggaggg cttcacccac gactggatgg tgttcgtacg 360 cggtccggag cacagtaaca tacagcactt tgtggagaaa gtcgtcttcc acttgcacga 420 aagctttcct aggccaaaaa gagtgtgcaa agatccacct tacaaagtag aagaatctgg 480 gtatgctggt ttcattttgc caattgaagt ttattttaaa aacaaggaag aacctaggaa 540 agtccgcttt gattatgact tattcctgca tcttgaaggc catccaccag tgaatcacct 600 ccgctgtgaa aagctaactt tcaacaaccc cacagaggac tttaggagaa agttgctgaa 660 ggcaggaggg gaccctaata ggagtattca taccagcagc agcagcagca gcagcagtag 720 cagcagcagc agcagcagca gcagcagcag tagcagcagc agcagcggca gcagcagcag 780 cagtagcagc agcagtagca gcagcagcag cagcagtagt accagttttt caaagcctca 840 caaattaatg aaggagcaca aggaaaaacc ttctaaagac tccagagaac ataaaagtgc 900 cttcaaagaa ccttccaggg atcacaacaa atcttccaaa gaatcctcta agaaacccaa 960 agaaaataaa ccactgaaag aagagaaaat agttcctaag atggccttca aggaacctaa 1020 acccatgtca aaagagccaa aaccagatag taacttactc accatcacca gtggacaaga 1080 taagaaggct cctagtaaaa ggccgcccat ttcagattct gaagaactct cagccaaaaa 1140 aaggaaaaag agtagctcag aggctttatt taaaagtttt tctagcgcac caccactgat 1200 actcacttgt tctgctgaca aaaaacagat aaaagataaa tctcatgtca agatgggaaa 1260 ggtcaaaatt gaaagtgaga catcagagaa gaagaaatca acgttaccgc catttgatga 1320 tattgtggat cccaatgatt cagatgtgga ggagaatata tcctctaaat ctgattctga 1380 acaacccagt cctgccagct ccagctccag ctccagctcc agcttcacac catcccagac 1440 caggcaacaa ggtcctttga ggtctataat gaaagatctg cattctgatg acaatgagga 1500 ggaatcagat gaagtggagg ataacgacaa tgactctgaa atggagaggc ctgtaaatag 1560 aggaggcagc cgaagtcgca gagttagctt aagtgatggc agcgatagtg aaagcagttc 1620 tgcttcttca cccctacatc acgaacctcc accaccctta ctaaaaacca acaacaacca 1680 gattcttgaa gtgaaaagtc caataaagca aagcaaatca gataagcaaa taaagaatgg 1740 tgaatgtgac aaggcatacc tagatgaact ggtagagctt cacagaaggt taatgacatt 1800 gagagaaaga cacattctgc agcagatcgt gaaccttata gaagaaactg gacactttca 1860 tatcacaaac acaacatttg attttgatct ttgctcgctg gacaaaacca cagtccgtaa 1920 actacagagt tacctggaaa catctggaac atcctgagga tataacaact ggatgcatca 1980 agaactattg tgtttttttt ttttggtttt tttttttttt tggttgtgat tttttgttct 2040 tgttgtttat atgaaaacac tcaaaatgat gcaaccaaaa gggaaaaaat aaaaatcaaa 2100 caacctccaa aaaaaaaaaa aaaa 2124 <210> SEQ ID NO 43 <211> LENGTH: 1539 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 43 gaattcgggg ggagggggca gtgtcctccg agccaggaca ggcatgttgt tgggactggc 60 ggccatggag ctgaaggtgt gggtggatgg catccagcgt gtggtctgtg gggtctcaga 120 gcagaccacc tgccaggaag tggtcatcgc actagcccaa gcaataggcc agactggccg 180 ctttgtgctt gtgcagcggc ttcgggagaa ggagcggcag ttgctgccac aagagtgtcc 240 agtgggcgcc caggccacct gcggacagtt tgccagcgat gtccagtttg tcctgaggcg 300 cacagggccc agcctagctg ggaggccctc ctcagacagc tgtccacccc cggaacgctg 360 cctaattcgt gccagcctcc ctgtaaagcc acgggctgcg ctgggctgtg agccccgcaa 420 aacactgacc cccgagccag cccccagcct ctcacgccct gggcctgcgg cccctgtgac 480 acccacacca ggctgctgca cagacctgcg gggcctggag ctcagggtgc agaggaatgc 540 tgaggagctg ggccatgagg ccttctggga gcaagagctg cgccgggagc aggcccggga 600 gcgagaggga caggcacgcc tgcaggcact aagtgcggcc actgctgagc atgccgcccg 660 gctgcaggcc ctggacgctc aggcccgtgc cctggaggct gagctgcagc tggcagcgga 720 ggcccctggg cccccctcac ctatggcatc tgccactgag cgcctgcacc aggacctggc 780 tgttcaggag cggcagagtg cggaggtgca gggcagcctg gctctggtga gccgggccct 840 ggaggcagca gagcgagcct tgcaggctca ggctcaggag ctggaggagc tgaaccgaga 900 gctccgtcag tgcaacctgc agcagttcat ccagcagacc ggggctgcgc tgccaccgcc 960 cccacggcct gacaggggcc ctcctggcac tcagggccct ctgcctccag ccagagagga 1020 gtccctcctg ggcgctccct ctgagtccca tgctggtgcc cagcctaggc cccgaggtgg 1080 cccccatgac gcagaactcc tggaggtagc agcagctcct gccccagagt ggtgtcctct 1140 ggcagcccag ccccaggctc tgtgacagcc tagtgagggc tgcaagacca tcctgcccgg 1200 accacagaag gagagttggc ggtcacagag ggctcctctg ccaggcagtg ggaagccctg 1260 ggtttggcct caggagctgg gggtgcagtg ggggactgcc ctagtccttg ccaggtcgcc 1320 cagcaccctg gagaagcatg gggcgtagcc agctcggaac ttgccaggcc ccaaaggcca 1380 cgactgcctg ttggggacag gagatgcatg gacagtgtgc tcaagctgtg ggcatgtgct 1440 tgcctgcggg agaggtcctt cactgtgtgt acacagcaag agcatgtgtg tgccacttcc 1500 cctaccccaa cgtgaaaacc tcaataaact gcccgaagc 1539 <210> SEQ ID NO 44 <211> LENGTH: 1514 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 44 cgcgcctgcc tctttctgag cggcatgaag ccacctccca ggcggcgagc ggccccggcg 60 cgctatctgg gcgaggtgac cggtcccgcg acctggagcg ctcgcgagaa gcggcagcta 120 gtgcgactcc tgcaggcgcg gcagggccag ccggagccgg acgccaccga gctggcccgg 180 gagctgcggg gccggagcga ggctgagatc cgggtcttcc tccagcagct caagggccgc 240 gtagcccggg aggccattca gaaagtgcat ccgggtggcc ttcagggacc aaggcgccgg 300 gaggcacagc ccccagcccc catagaggtc tggacggatc tggctgagaa gataacaggg 360 ccactggaag aagccctggc agtggctttc tcgcaggtgc tcaccatcgc ggccacggaa 420 ccggtcaccc tcctgcactc caagcccccc aagcccacgc aggcccgtgg aaagcctttg 480 ctcctgagcg cccctggagg acaggaagac cccgcccctg aaatacctag ctctgcccct 540 gctgcaccta gctccgcacc caggactcct gaccctgccc ctgagaaacc ttctgagtcg 600 tcggctggtc cctccactga agaagacttt gctgtggact ttgagaagat ctacaagtac 660 ttgtcctctg tctcccgaag tggccgcagc cccgagctct cagcagctga gtccgctgtg 720 gtcctcgacc tgctcatgtc acttccagag gagctgccac tcctgccctg cacagccctg 780 gttgagcata tgacggagac gtacctacgc ctgacagccc cccagcccat tcccgctgga 840 gggagcctgg ggcctgcagc agaaggggat ggggctggct ccaaggcacc agaggagacc 900 cccccagcca ccgagaaggc cgagcacagc gaactgaaat cgccttggca agcagctggg 960 atctgtcccc tgaacccgtt cctggtgccc ctggagcttc tgggtcgggc agccacccct 1020 gccaggtgag gggcatggcg ggcaggaggc cacaccaggc cccccgccct gcccctcggt 1080 tctgctcggc tggccctggc tctttctgag gatcccgtca tgggggaagg tccttgagat 1140 gatgctcagc tgtggggcgg gcctctaaga tgccccatac tttgggggtc tcagaaatgg 1200 aacccccgtt gtacaggggt tgggtggggg ttgcaggact ccactcacaa gcctcctgat 1260 gtcaaggaca ggcggacagg gctggcctcc cccagtcccc aagccccact gtgccttgtt 1320 gtctgctggg gggccatagc tggcactgcc caccgtaaag gccctcgcac attttccccc 1380 ttcctgtaca cctcggggcc agcatcctca ccttcttcaa ctgaccagtc gtggttactc 1440 cctgctgcca ggtccttccc cttcccgggg gtattctgtg accatgaata aagttaccat 1500 tctctttctc tttc 1514 <210> SEQ ID NO 45 <400> SEQUENCE: 45 000 <210> SEQ ID NO 46 <211> LENGTH: 2744 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 ctcgtgccga attcggcacg agaccgcgtg ttcgcgcctg gtagagattt ctcgaagaca 60 ccagtgggcc cgtgtggaac caaacctgcg cgcgtggccg ggccgtggga caacgaggcc 120 gcggagacga aggcgcaatg gcgaggaagt tatctgtaat cttgatcctg acctttgccc 180 tctctgtcac aaatcccctt catgaactaa aagcagctgc tttcccccag accactgaga 240 aaattagtcc gaattgggaa tctggcatta atgttgactt ggcaatttcc acacggcaat 300 atcatctaca acagcttttc taccgctatg gagaaaataa ttctttgtca gttgaagggt 360 tcagaaaatt acttcaaaat ataggcatag ataagattaa aagaatccat atacaccatg 420 accacgacca tcactcagac cacgagcatc actcagacca tgagcgtcac tcagaccatg 480 agcatcactc agaccacgag catcactctg accataatca tgctgcttct ggtaaaaata 540 agcgaaaagc tctttgccca gaccatgact cagatagttc aggtaaagat cctagaaaca 600 gccaggggaa aggagctcac cgaccagaac atgccagtgg tagaaggaat gtcaaggaca 660 gtgttagtgc tagtgaagtg acctcaactg tgtacaacac tgtctctgaa ggaactcact 720 ttctagagac aatagagact ccaagacctg gaaaactctt ccccaaagat gtaagcagct 780 ccactccacc cagtgtcaca tcaaagagcc gggtgagccg gctggctggt aggaaaacaa 840 atgaatctgt gagtgagccc cgaaaaggct ttatgtattc cagaaacaca aatgaaaatc 900 ctcaggagtg tttcaatgca tcaaagctac tgacatctca tggcatgggc atccaggttc 960 cgctgaatgc aacagagttc aactatctct gtccagccat catcaaccaa attgatgcta 1020 gatcttgtct gattcataca agtgaaaaga aggctgaaat ccctccaaag acctattcat 1080 tacaaatagc ctgggttggt ggttttatag ccatttccat catcagtttc ctgtctctgc 1140 tgggggttat cttagtgcct ctcatgaatc gggtgttttt caaatttctc ctgagtttcc 1200 ttgtggcact ggccgttggg actttgagtg gtgatgcttt tttacacctt cttccacatt 1260 ctcatgcaag tcaccaccat agtcatagcc atgaagaacc agcaatggaa atgaaaagag 1320 gaccactttt cagtcatctg tcttctcaaa acatagaaga aagtgcctat tttgattcca 1380 cgtggaaggg tctaacagct ctaggaggcc tgtatttcat gtttcttgtt gaacatgtcc 1440 tcacattgat caaacaattt aaagataaga agaaaaagaa tcagaagaaa cctgaaaatg 1500 atgatgatgt ggagattaag aagcagttgt ccaagtatga atctcaactt tcaacaaatg 1560 aggagaaagt agatacagat gatcgaactg aaggctattt acgagcagac tcacaagagc 1620 cctcccactt tgattctcag cagcctgcag tcttggaaga agaagaggtc atgatagctc 1680 atgctcatcc acaggaagtc tacaatgaat atgtacccag agggtgcaag aataaatgcc 1740 attcacattt ccacgataca ctcggccagt cagacgatct cattcaccac catcatgact 1800 accatcatat tctccatcat caccaccacc aaaaccacca tcctcacagt cacagccagc 1860 gctactctcg ggaggagctg aaagatgccg gcgtcgccac tttggcctgg atggtgataa 1920 tgggtgatgg cctgcacaat ttcagcgatg gcctagcaat tggtgctgct tttactgaag 1980 gcttatcaag tggtttaagt acttctgttg ctgtgttctg tcatgagttg cctcatgaat 2040 taggtgactt tgctgttcta ctaaaggctg gcatgaccgt taagcaggct gtcctttata 2100 atgcattgtc agccatgctg gcgtatcttg gaatggcaac aggaattttc attggtcatt 2160 atgctgaaaa tgtttctatg tggatatttg cacttactgc tggcttattc atgtatgttg 2220 ctctggttga tatggtacct gaaatgctgc acaatgatgc tagtgaccat ggatgtagcc 2280 gctgggggta tttcttttta cagaatgctg ggatgctttt gggttttgga attatgttac 2340 ttatttccat atttgaacat aaaatcgtgt ttcgtataaa tttctagtta aggtttaaat 2400 gctagagtag cttaaaaagt tgtcatagtt tcagtaggtc atagggagat gagtttgtat 2460 gctgtactat gcagcgttta aagttagtgg gttttgtgat ttttgtattg aatattgctg 2520 tctgttacaa agtcagttaa aggtacgttt taatatttaa gttattctat cttggagata 2580 aaatctgtat gtgcaattca ccggtattac cagtttatta tgtaaacaag agatttggca 2640 tgacatgttc tgtatgtttc agggaaaaat gtctttaatg ctttttcaag aactaacaca 2700 gttattccta tactggattt taggtctctg aagaactgct ggtg 2744 <210> SEQ ID NO 47 <211> LENGTH: 1759 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 47 agcggatgct ggggctgtaa ggcgcgcgcg gtcagctgtt ggcggtgcag ggaggaggac 60 gccggggctc gccttccctc ctctgccgcc gctgccgcca tgattccggt gtcgctggtg 120 gtggtggtgg tgggtggctg gactgtcgtc tacctgaccg acttggtgct gaagtcatct 180 gtctatttta aacattctta tgaagactgg ctggaaaaca acggactgag catctcccct 240 ttccacataa gatggcaaac tgctgttttc aatcgtgcct tttacagttg gggacggcgg 300 aaagcaagga tgctttacca atggttcaat tttggaatgg tgtttggcgt aattgccatg 360 tttagctcat tttttctcct tggaaaaacg ctgatgcaga ctttggcaca aatgatggct 420 gactctccct cttcttattc ttcctcctct tcttcctctt cctcctcttc ttcctcttcc 480 tcttcttcat cttcttcctc ttcctcgctt cacaatgaac aggtgttaca agttgtggtt 540 cctggtataa atttacccgt caatcaactg acctatttct tcacggcagt tctcattagt 600 ggtgttgtac atgaaattgg acatgggata gcagctatta gggaacaagt tcgatttaat 660 ggctttggga tttttctctt cattatttat cctggagcat ttgttgatct gttcaccact 720 catttgcaac ttatatcgcc agtccagcag ctaaggatat tttgtgcagg tatctggcat 780 aattttgtcc ttgcactctt gggtatttta gctcttgttc tcctcccagt aattctcttg 840 ccattttact acactggagt tggggtgctc atcactgaag ttgctgagga ctctcctgcc 900 attggaccca gaggcctttt tgtgggagac cttgtcaccc atctacagga ttgtcctgtt 960 actaatgtgc aagattggaa tgaatgttta gataccatcg cctatgagcc ccaaattggt 1020 tactgtataa gtgcatcaac tttacagcag ttaagtttcc cagttagagc atacaaacga 1080 ctagatggtt caactgaatg ctgtaacaat cacagcctca cagatgtgtg cttttcctac 1140 agaaataatt ttaataagcg tttgcataca tgtcttcctg cccggaaagc agttgaagca 1200 actcaagttt gcagaaccaa taaagactgt aaaaaaagct caagttcaag tttctgtata 1260 ataccttctt tggaaactca cactcgctta ataaaagtaa aacacccacc tcagattgat 1320 atgttatacg taggacatcc tctgcatctt cactacacag tgagcatcac cagttttatc 1380 ccacgtttta actttctaag catagatctg ccagtggttg tggagacatt tgtcaagtac 1440 ctgatttccc tctcaggagc tctggctatt gttaatgcag taccctgctt tgctttggat 1500 ggacaatgga ttctaaactc tttcttggat gccaccctta cctcagtgat tggagacaat 1560 gatgtcaaag atctaatagg gtttttcatc ttgctgggtg gcagtgtact tttggctgcc 1620 aatgtgaccc tgggactctg gatggttaca gcacggtaat gtttgcactc atctgacaga 1680 atccctgagt tacagtatac agctatgtgg taatattcat tgccattgaa attcttactt 1740 ggtatgaaat ataaagtgt 1759 <210> SEQ ID NO 48 <211> LENGTH: 1610 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 48 ggcacgaggc tgcggccgca gtagccggag ccggagccgc agccaccggt gccttccttt 60 cccgccgccg cccagccgcc gtccggcctc cctcgggccc gagcgcagac caggctccag 120 ccgcgcggcg ccggcagcct cgcgctccct ctcgggtctc tctcgggcct cgggcaccgc 180 gtcctgtggg cggccgcctg cctgcccgcc cgcccgcagc cccttgcctg ccggcccctg 240 ggcggcccgt gccatgggca ccgacagccg cgcggccaag gcgctcctgg cgcgggcccg 300 caccctgcac ctgcagacgg ggaacctgct gaactggggc cgcctgcgga agaagtgccc 360 gtccacgcac agcgaggagc ttcatgattg tatccaaaaa accttgaatg aatggagttc 420 ccaaatcaac ccagatttgg tcagggagtt tccagatgtc ttggaatgca ctgtatctca 480 tgcagtagaa aagataaatc ctgatgaaag agaagaaatg aaagtttctg caaaactgtt 540 cattgtagaa tcaaactctt catcatcaac tagaagtgca gttgacatgg cctgttcagt 600 ccttggagtt gcacagctgg attctgtgat cattgcttca cctcctattg aagatggagt 660 taatctttcc ttggagcatt tacagcctta ctgggaggaa ttagaaaact tagttcagag 720 caaaaagatt gttgccatag gtacctctga tctagacaaa acacagttgg aacagctgta 780 tcagtgggca caggtaaaac caaatagtaa ccaagttaat cttgcctcct gctgtgtgat 840 gccaccagat ttgactgcat ttgctaaaca atttgacata cagctgttga ctcacaatga 900 tccaaaagaa ctgctttctg aagcaagttt ccaagaagct cttcaggaaa gcattcctga 960 cattcaagcg cacgagtggg tgccgctgtg gctactgcgg tattcggtca ttgtgaaaag 1020 tagaggaatt atcaaatcaa aaggctacat tttacaagct aaaagaaggg gttcttaact 1080 gacttaggag cataacttac ctgtaatttc cttcaatatg agagaaaatt gagatgtgta 1140 aaatctagtt actgcctgta aatggtgtca ttgaggcaga tattctttcg tcatatttga 1200 cagtatgttg tctgtcaagt tttaaatact tatcttgcct ccatatcaat ccattctcat 1260 gaacctctgt attgctttcc ttaaactatt gttttctaat tgaaattgtc tataaagaaa 1320 atacttgcaa tatatttttc ctttattttt atgactaata taaatcaaga aaatttgttg 1380 ttagatatat tttggcctag gtatcagggt aatgtatata catatttttt atttccaaaa 1440 aaaattcatt aattgcttct taactcttat tataaccaag caatttaatt acaattgtta 1500 aaactgaaat actggaagaa gatatttttc ctgtcattga tgagatatat cagagtaact 1560 ggagtagctg ggatttacta gtagtgtaaa taaaattcac tcttcaatac 1610 <210> SEQ ID NO 49 <211> LENGTH: 2044 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 49 ctggacgagt ccgagcgcgt cacctcctca cgctgcggct gtcgcccgtg tcccgccggc 60 ccgttccgtg tcgccccgca gtgctgcggc cgccgcggca ccatggctgt gtttgtcgtg 120 ctcctggcgt tggtggcggg tgttttgggg aacgagttta gtatattaaa atcaccaggg 180 tctgttgttt tccgaaatgg aaattggcct ataccaggag agcggatccc agacgtggct 240 gcattgtcca tgggcttctc tgtgaaagaa gacctttctt ggccaggact cgcagtgggt 300 aacctgtttc atcgtcctcg ggctaccgtc atggtgatgg tgaagggagt gaacaaactg 360 gctctacccc caggcagtgt catttcgtac cctttggaga atgcagttcc ttttagtctt 420 gacagtgttg caaattccat tcactcctta ttttctgagg aaactcctgt tgttttgcag 480 ttggctccca gtgaggaaag agtgtatatg gtagggaagg caaactcagt gtttgaagac 540 ctttcagtca ccttgcgcca gctccgtaat cgcctgtttc aagaaaactc tgttctcagt 600 tcactccccc tcaattctct gagtaggaac aatgaagttg acctgctctt tctttctgaa 660 ctgcaagtgc tacatgatat ttcaagcttg ctgtctcgtc ataagcatct agccaaggat 720 cattctcctg atttatattc actggagctg gcaggtttgg atgaaattgg gaagcgttat 780 ggggaagact ctgaacaatt cagagatgct tctaagatcc ttgttgacgc tctgcaaaag 840 tttgcagatg acatgtacag tctttatggt gggaatgcag tggtagagtt agtcactgtc 900 aagtcatttg acacctccct cattaggaag acaaggacta tccttgaggc aaaacaagcg 960 aagaacccag caagtcccta taaccttgca tataagtata attttgaata ttccgtggtt 1020 ttcaacatgg tactttggat aatgatcgcc ttggccttgg ctgtgattat cacctcttac 1080 aatatttgga acatggatcc tggatatgat agcatcattt ataggatgac aaaccagaag 1140 attcgaatgg attgaatgtt acctgtgcca gaattagaaa agggggttgg aaattggctg 1200 ttttgttaaa atatatcttt tagtgtgctt taaagtagat agtatacttt acatttataa 1260 aaaaaaatca aattttgttc tttattttgt gtgtgcctgt gatgtttttc tagagtgaat 1320 tatagtattg acgtgaatcc cactgtggta tagattccat aatatgcttg aatattatga 1380 tatagccatt taataacatt gatttcattc tgtttaatga atttggaaat atgcactgaa 1440 agaaatgtaa aacatttaga atagctcgtg ttatggaaaa aagtgcactg aatttattag 1500 acaaacttac gaatgcttaa cttctttaca cagcataggt gaaaatcata tttgggctat 1560 tgtatactat gaacaatttg taaatgtctt aatttgatgt aaataactct gaaacaagag 1620 aaaaggtttt taacttagag tagccctaaa atatggatgt gcttatataa tcgcttagtt 1680 ttggaactgt atctgagtaa cagaggacag ctgtttttta accctcttct gcaagtttgt 1740 tgacctacat gggctaatat ggatactaaa aatactacat tgatctaaga agaaactagc 1800 cttgtggagt atatagatgc ttttcattat acacacaaaa atccctgagg gacattttga 1860 ggcatgaata taaaacattt ttatttcagt aacttttccc cctgtgtaag ttactatggt 1920 ttgtggtaca acttcattct atagaatatt aagtggaagt gggtgaattc tactttttat 1980 gttggagtgg accaatgtct atcaagagtg acaaataaag ttaatgatga ttccaaaaaa 2040 aaaa 2044 <210> SEQ ID NO 50 <211> LENGTH: 2266 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 50 agcggagcag tagccaccac tccgccgagg ccgcaacccc ggctcggcct ccccaggccc 60 cgccgctgcc gcagtcatgg ctgctgatgg ggtggacgaa cgctcgcctc tgctgtcagc 120 atcccactcc ggaaatgtca ctcccaccgc cccaccgtac ttgcaagaaa gcagccccag 180 agcggagctc ccacctccat atacagccat tgccagtcca gacgccagtg gtattccagt 240 aataaactgc cgtgtgtgcc aatcactaat caatttggat ggcaagcttc accagcatgt 300 ggttaagtgc acagtttgca atgaagctac gccaatcaaa aaccccccaa caggcaagaa 360 atatgttaga tgcccttgta attgtcttct catttgtaag gacacatctc ggcgaatagg 420 atgcccaaga cccaactgta gacggataat taaccttggc ccagtaatgc ttatttctga 480 agaacaacca gctcagcctg cattgccaat ccaaccagaa ggtacaaggg tcgtgtgtgg 540 gcactgtgga aacacattcc tgtggatgga actgaggttc aacactctgg caaaatgccc 600 acactgcaaa aaaatctcct cagtgggtag tgcacttcca cgaagacgct gctgtgcata 660 tattaccatt ggaatgatat gtattttcat tggagttggg ttaactgttg gcaccccaga 720 ttttgcaagg cgatttcgag caacctatgt ttcttgggca attgcttatc tcctaggatt 780 gatctgcctt atccgagctt gttattgggg agccataaga gtcagttatc cagaacacag 840 ttttgcataa gcttgtttat gattcagtaa tgcaggtgag agtgtctagc agttcttggt 900 aagctactct ggacatcttt aaattattta tcctaatgga ttccattctg gtttatgtat 960 aatcgtttca agactttggg agtcttttat gaacaaatgc tcattgcact atattatatg 1020 caaattgttt tgctgctagg ttttcaaaat ttgaataata aagccttttc atgttctttt 1080 acatctctta tagatatttt tggatttgtt accaaacatt acatttactc tcaccctttt 1140 attattttta aataagttat ttcattactt gctgatacat gagtattcct aagtgtttat 1200 aaatatttct ataatagttt cacatttata tttacatttt aattaaacag tatcaaaatt 1260 gcttgcttaa aacctaagca atatgcattt tgcttgaact gcttactgta actttaacct 1320 aagattatag tgaccttatt caggaaaaaa aaaaaattta gtgtaacttc aaagacttga 1380 cattcttgtc agaggaaaaa aaatttctag atactgtttg cttgtttttt gttgtttgta 1440 gaaagataaa atattttggt aataatttaa aatacaagaa cgaatattta tttgtccaca 1500 gttggagatg ttggataaat gtcttttctc aaagatcaca ggacttttgt ctttcatttt 1560 tgccttttta tttaccattt ataaaagatc tggtctggat tatggaattt aatgtttatc 1620 agctctatgt attcctttat agaggcttga ggaagtattt cacataacat gttttataat 1680 acttaaccat ttatccaaag atatatttac attgggttgt gcccctttcc cttagatcat 1740 ggtaaatttt tcttattgag gtaattatgt actacttata tttgaaggaa gcttatgaca 1800 ttttacagta gctaaaatgt tgagattaga ggtactttta ctattcttct caaaggtaac 1860 tgatcagata attacccaaa ttattcaaga aaatagatca gaaataaaga acaacataat 1920 tttctaagaa ttcattgaaa tttatggaat cagctctcgc actgcccatc tttgcagttt 1980 tgaaaaagaa attgcttaat cacaaatgtt ctacagtctt taaatgtagt agaattagac 2040 agtgagatca tctgagtaaa ttgattggtg attccagaga taagactaat attttaaatt 2100 atttatgata ctgattagta taaaaacgta ctcatcacag aatttgaagc aaaatacatg 2160 tacacttcaa agagtaaatg acaaatgtat aaatgctgta gctcaggatt atatgtacct 2220 ttaaaaatac actaataaag attattgttc aaaaaaaaaa aaaaaa 2266 <210> SEQ ID NO 51 <211> LENGTH: 3142 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 51 gtggccgctg ccgcctctgc ctgggtccct tcggccgtac ctctgcgtgg gggctgcctc 60 cccggctccc ggtgcagaca ccatgtacgg atttgtgaat cacgccctgg agttgctggt 120 gatccgcaat tacggccccg aggtgtggga agacatcaaa aaagaggcac agttagatga 180 agaaggacag tttcttgtca gaataatata tgatgactcc aaaacttatg atttggttgc 240 tgctgcaagc aaagtcctca atctcaatgc tggagaaatc ctccaaatgt ttgggaagat 300 gtttttcgtc ttttgccaag aatctggtta tgatacaatc ttgcgtgtcc tgggctctaa 360 tgtcagagaa tttctacaga accttgatgc tctgcacgac caccttgcta ccatctaccc 420 aggaatgcgt gcaccttcct ttaggtgcac tgatgcagaa aagggcaaag gactcatttt 480 gcactactac tcagagagag aaggacttca ggatattgtc attggaatca tcaaaacagt 540 ggcacaacaa atccatggca ctgaaataga catgaaggtt attcagcaaa gaaatgaaga 600 atgtgatcat actcaatttt taattgaaga aaaagagtca aaagaagagg atttttatga 660 agatcttgac agatttgaag aaaatggtac ccaggaatca cgcatcagcc catatacatt 720 ctgcaaagct tttccttttc atataatatt tgaccgggac ctagtggtca ctcagtgtgg 780 caatgctata tacagagttc tcccccagct ccagcctggg aattgcagcc ttctgtctgt 840 cttctcgctg gttcgtcctc atattgatat tagtttccat gggatccttt ctcacatcaa 900 tactgttttt gtattgagaa gcaaggaagg attgttggat gtggagaaat tagaatgtga 960 ggatgaactg actgggactg agatcagctg cttacgtctc aagggtcaaa tgatctactt 1020 acctgaagca gatagcatac tttttctatg ttcaccaagt gtcatgaacc tggacgattt 1080 gacaaggaga gggctgtatc taagtgacat ccctctgcat gatgccacac gcgatcttgt 1140 tcttttggga gaacaattta gagaggaata caaactcacc caagaactgg aaatcctcac 1200 tgacaggcta cagctcacgt taagagccct ggaagatgaa aagaaaaaga cagacacatt 1260 gctgtattct gtccttcctc cgtctgttgc caatgagctg cggcacaagc gtccagtgcc 1320 tgccaaaaga tatgacaatg tgaccatcct ctttagtggc attgtgggct tcaatgcttt 1380 ctgtagcaag catgcatctg gagaaggagc catgaagatc gtcaacctcc tcaacgacct 1440 ctacaccaga tttgacacac tgactgattc ccggaaaaac ccatttgttt ataaggtgga 1500 gactgttggt gacaagtata tgacagtgag tggtttacca gagccatgca ttcaccatgc 1560 acgatccatc tgccacctgg ccttggacat gatggaaatt gctggccagg ttcaagtaga 1620 tggtgaatct gttcagataa caatagggat acacactgga gaggtagtta caggtgtcat 1680 aggacagcgg atgcctcgat actgtctttt tgggaatact gtcaacctca caagccgaac 1740 agaaaccaca ggagaaaagg gaaaaataaa tgtgtctgaa tatacataca gatgtcttat 1800 gtctccagaa aattcagatc cacaattcca cttggagcac agaggcccag tgtccatgaa 1860 gggcaaaaaa gaaccaatgc aagtttggtt tctatccaga aaaaatacag gaacagagga 1920 aacaaagcag gatgatgact gaatcttgga ttgtggggtg aagaggagta cagactaggt 1980 tccagttttc tcctaacacg tgccaagccc aggagcagtt cttccctatg gatacagatt 2040 ttcttttgtc cttgtccatt accccaagac tttcttctag atatatctct cactatccgt 2100 tattcaacct tagctctgct ttctattact ttttaggctt tagtatatta tctaaagttt 2160 ggcttttgat gtggatgatg tgagcttcat gtgtcttaaa atctactaca agcattacct 2220 aacatggtga tctgcaagta gtaggcaccc aataaatatt tgttgaattt agttaaatga 2280 aactgaacag tgtttggcca tgtgtatatt tatatcatgt ttaccaaatc tgtttagtgt 2340 tccacatata tgtatatgta tattttaatg actataatgt aataaagttt atatcatgtt 2400 ggtgtatatc attatagaaa tcattttcta aaggagtgaa ttctaagttt taggggaaaa 2460 aatgcaattt attttcagac tcccaaagta agaattaaca tatcatgcta agaaaatagt 2520 gactattttg aagtatgcta cttccctttc agaaatatag aatacacgtt tctgttatta 2580 aagtatttga ttactaattc aaatcatatg gcaattataa ttcttctaaa atgctatcat 2640 ttgtaactgt atcccctgta ttaaatctca ttaaccacag gcagctgtta cagaaagctg 2700 cattgtttca cattgagctg ttacattagt tcaggctaaa tgttgggcgc tccaaccaca 2760 tccaagaata aatctggaaa cacactgctg ggatactgct gttagagccc ttcttggcct 2820 tgtattccca gaaatgagct ccctttcctt agcttagaag aatgtgatta tatccaggac 2880 atcatgttca gaaaacttag tttactttca gcatagaatg cattactgtt ggaataattg 2940 gcctctagct cttaaatgtc tctgataact tattaatatc tatctttata aaatagagtg 3000 caactacttt tgtgtaaaaa tgtttgcctt taaatttagt atttcatatc agcacatcga 3060 tatatgtata aatgttccat gttaatgtgt aaaagagtct gtaataaatt atttttttca 3120 cgtgtcaaaa aaaaaaaaaa aa 3142 <210> SEQ ID NO 52 <211> LENGTH: 5537 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 ggaactgccg cggccgccac cgccgctgcc ggcgccgctg ctgtagggga ccagcgcggg 60 tgcgcagacg aaaggcgctc tttgccagct gaaagttccc acggaaaaac taccatctcc 120 cctgcccacc atggcagacg aaattgattt cactactgga gatgccgggg cttccagcac 180 ttaccctatg cagtgctcgg ccttgcgcaa aaacggcttc gtggtgctca aaggacgacc 240 atgcaaaata gtggagatgt caacttccaa aactggaaag catggtcatg ccaaggttca 300 ccttgttgga attgatattt tcacgggcaa aaaatatgaa gatatttgtc cttctactca 360 caacatggat gttccaaata ttaagagaaa tgattatcaa ctgatatgca ttcaagatgg 420 ttacctttcc ctgctgacag aaactggtga agttcgtgag gatcttaaac tgccagaagg 480 tgaactaggc aaagaaatag agggaaaata caatgcaggt gaagatgtac aggtgtctgt 540 catgtgtgca atgagtgaag aatatgctgt agccataaaa ccctgcaaat aaacggaaac 600 atcaggcatg aacactgttt atgtctgaat caactgcaga tctaatttgg ttctaagttg 660 tcaccaaagc tatagccttc ataagcaacc tcatttcttt ttttaattgt tttcagattg 720 tgctgggtta gttttgcaag caattgataa tttttaaaaa attatcaata tgtataattt 780 tttttgaatt ttgtagatat gtttcctata atattcctgt ggttttcagt atgtcagtcc 840 aagaaacaaa caagatagct tcagcagatg tgatttgtct gagcaaatca ttcctgtgtt 900 ttagttagat gataaaccag ggttttaaat caaacaatgt agcataaagt ggtattgaag 960 taccatattt aagttgaact gctctgcatt aattacagat ttaatataaa atgaactgat 1020 tatatattgg aattgttgca ctttcagcct gtgtagggca aacacaaatc cttaaacaaa 1080 aatcatgtta tcaaaaactg tcagttattt tggtggccac atgcaaccat gtgattactt 1140 tggtcatact atttaccaaa ttgttggcaa acttgatgta accttatatg gtggttttag 1200 tcccttctta tggttggcag aagggcactg aactgttggg tgaaagttag ttagcaagta 1260 agattataag gaagacacaa aagacagtgg caaagagggt tgattaaatc tataagtttt 1320 tatgtgagga ctttgtaagt cagcataaaa atgaaaagtt gtttctcagt tgtttttgct 1380 tttaactttg cccccaacgt ttaaagggag tgatctgctt tacatgatac tatgcaatgc 1440 ttgttttcca actatgttga ataaatagta atatttatca gtaaatactc ctttccaact 1500 tccttttttt tttttttttt tttgagactg agtctcactc catcagccag gctggagtgc 1560 agtggtgcaa tctcggctca ctgcaacctc tgcctcccga gttcaagcaa ttctcctgcc 1620 tcagcctccc aagtagctgg gactacaggt gcatgccacc acgcccagct acttttttgt 1680 gtattttagt agagatgggg tttcaccatg ttgtctaggc tggtcttgaa ctcctgacct 1740 caggtgatcc acctgcctca gcctcccaaa gtgctgggat tacaggcatg agccaccaca 1800 cccagcccct ttccaaccat ttctaagtag attttttgac attaatgtat ttattaaaca 1860 aaaactgaga attccttaaa ttgatttgga atttttgtta attttatgtc ctttttttcc 1920 taaagtgaat taaagtgaat catggaagca gcattacttt atatgaatat tattatttaa 1980 gttaagttat tttaagtata tgcatttttt ctgattgttg tgtgacttaa ttcagttgct 2040 ggtgtgaact ataactagca aataattcta taaactgaat tattttaaaa ggtattttag 2100 gtgacaccac tgcatttcta tttcatcttt tgagtcatat gtatattatt tccagaattt 2160 tagacattat tacagggttt gtgaggacct ttgactcagt gacaatcatc atattggagc 2220 aaaacataga acaaaatcac tatctcagaa ataccttaat tctctaagac tggctcttag 2280 acctctccca tcatgccttg acctctaaaa agccctttgt tcctatcttc taaaggaaag 2340 tatatcatat atgatgatgt aactgatcta atcagtgact ggaaatagca ttagtaacag 2400 aagatcccaa gttttagttg cttaatttgt acacactttt aaatattgtc ttagcctcgg 2460 caaaccaatt tggggaagaa gcaagatact ttaagagaaa tacaaaggaa atttctaaag 2520 cacaagaaat agtgaggtag tagttagtcg tctttcctac aacattttag cttttgccca 2580 tctaaagcac aattaaaatt aggctacatt ctttccagta ttctatttaa gtacctacta 2640 catactgctc tagtttctta gtactctgta atgtgtatct taattgctac tggttggcat 2700 tgtaactcat aggaattcca gaaaattatt aatccgtgct gcttgcagtt cattcatatg 2760 gcccctctta accatgctgg tgttatgatt cagtattaac tctcaattag catgcccctg 2820 ttcttcctaa cttgtaaaat ttcacataaa tatattttca attgtgtaca aattaagggt 2880 gtacaaatta taataatgca tctctatctt catactttga atggcaaacg ctatttatgc 2940 ataaatattt tcattttaag taatatatga agtgtaaata ctcgatatat aagtatagat 3000 tttaaagata tgggacttta ttttcacata agtcaataga tgtttctcta gaacaaaata 3060 tttagtaaag ctttataaat tatattaaaa ggaagcgggg aacatgtatt ttttaacata 3120 gaacagaagt gacttcattc tttttagaca tcagaaatgt taaagttgat tcccaatatt 3180 tgttgtactt ttttgtagca aatgttaaaa atcacgagtt accatgtata gaatgtggac 3240 tgtcatgttg atatcattgt acagtgataa gccattttta tctgtataca tttcaccaat 3300 ttattaacag gttgaatatt tgtttctttt tagaacattt tatttatact gtgaagactt 3360 tgttatacct tatttgctac aacatagatc atatcattgc tactttgact tagcatttgc 3420 atcataaaca taattatgat gtttttttca tgctcccttc caggggctca gtcacttgaa 3480 gaaactgttg ctaaccaagc tcttgactct gtttccctta atgatacaag tctctgtacc 3540 agcgctttat gttaattacc aaaactctcc tgcatcagag catgatatct ataataggag 3600 atactgcaat aaaatgatta ggctgtaaaa tttggagaca caatttttca ttacaatgca 3660 atttgcatgt gcacatgtgc gcacataact ttatatgtta gttctttttt ccaaactccc 3720 aactcttaaa agtattgtag tctgttggtg cctcaactgt tggtaacttt ttttttttaa 3780 atttacaact ttccacaact tgtttttgta ctttaaggtt tctcaattag aatatttcta 3840 gttgagctgt aatttgaatg cattgttctc agggctattt gtgctaaaag ctgaaatttc 3900 attattttaa agctaattgc ctgaaaatat attggcagaa ttttcccaaa ttgtaataac 3960 tgtgatacat gcatataaaa aaatccttaa tgtcaacaca cttaaactac atgctaaata 4020 gtcaagaaaa aaatggaaac agtagcatcc atactggaat cttgccatat ttttttcatt 4080 ttagaataga ttttggcagt ctcatcttag aatcctatcc ttaggataca tctgaaagca 4140 ttcctttggc atggacccca gagatagttt tggagccagg cattgatgta gaggttcacc 4200 aaacatattt agggataata gataaattca taatgctttt ttgggtacac tgaaatgttt 4260 acatactgaa ttctgtaata tgaactagga acgcatttac tatgagaaaa tatggctctt 4320 aagcagtgta agagtgaaaa tataagcata tttccattaa cagtatattg tactgatcag 4380 cagctctcat tttaacatca gttaggcata atatttcata gttttcaagc cttttttttc 4440 tgctaacatt cagacaagta acaggcaaca aagatttaag aaaaatttat ggtggaaaac 4500 cttaaaaatt gagacaattc aatctattta atctattaaa ttttttctct gaattgggta 4560 tatggcatca ttatttgatt ttagcaggga acatttggat ttagcttatg aaacacagat 4620 gttctatggg aacatggctt gaagccaata tgtaatttaa tgtttttcca ttaaacaaac 4680 atctgaacac caacttagct accaagtgag gtcaagtgcc tgaaaagtac tgtatacatc 4740 taataagcat gttttcctta tgtaaaagat gcactttatg gcaatgcata ccaggctttc 4800 acctgctaga aacatacttg ttgccaactt tgccatctac cactattctc ctccttagaa 4860 caggtagaaa cctattttac aaaaaaaaaa aaaaaaaaaa aaagacaggt tattgtattt 4920 atatgaagtc cctaaaactg tttcttggta ttgatagact taagtttatc ttagttcaag 4980 attgcacttt ttaaaaaact ctggactatt ttcagcaatg accgaacagc ttgtcacaca 5040 tcatagttgt gatctttttt gaggagttat ttattgtggt taatatctac tataaataag 5100 cattcttgtg cttgttacaa agcataatgc aaattactag ttctatacta gtataatgaa 5160 aatgactagt tctatactgt tatgtacttt tgtcttcctc cccaaaaagg aaacagttta 5220 gcattgtcta aattcagtgg cactttttta gtaatacatt tttttttctt agatacagga 5280 gaactattgc ttttacctgc agaaactcaa atgttttcgc taaaacttta aaattctaaa 5340 atacgtagta tgggtattac taattgtaca ttttacattt caaaaatagt taaaattcaa 5400 atgttaagtc tttgacttaa aaaaccttta aatatagata ataccttaac aattataact 5460 ttgtgatatt attaaaatat atttgtctgt taacttcatc agttgtatta aataaaaata 5520 gttaacagct tgcacta 5537 <210> SEQ ID NO 53 <211> LENGTH: 1444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 53 tttcattttg ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac 60 cccgggagtt aatccgaaag cgccgcaagc cccgcgggcc ggccgcaccg cacgtgtcac 120 cgagaagctg atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg 180 ggaaagtcct gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc 240 agccaccgcc ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc 300 tgcagtgccg gctcagcatg tgtccagcgc gcagcctcct ccttgtggct accctggtcc 360 tcctggacca cctcagtttg gccagaaacc tccccgtggc cactccagac ccaggaatgt 420 tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg ctccagaagg 480 ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca 540 caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga 600 gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa 660 agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc 720 aggtggagtt caagaccatg aatgcaaagc ttctgatgga tcctaagagg cagatctttc 780 tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg 840 agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc 900 tctgcatact tcttcatgct ttcagaattc gggcagtgac tattgataga gtgatgagct 960 atctgaatgc ttcctaaaaa gcgaggtccc tccaaaccgt tgtcattttt ataaaacttt 1020 gaaatgagga aactttgata ggatgtggat taagaactag ggagggggaa agaaggatgg 1080 gactattaca tccacatgat acctctgatc aagtattttt gacatttact gtggataaat 1140 tgtttttaag ttttcatgaa tgaattgcta agaagggaaa atatccatcc tgaaggtgtt 1200 tttcattcac tttaatagaa gggcaaatat ttataagcta tttctgtacc aaagtgtttg 1260 tggaaacaaa catgtaagca taacttattt taaaatattt atttatataa cttggtaatc 1320 atgaaagcat ctgagctaac ttatatttat ttatgttata tttattaaat tatttatcaa 1380 gtgtatttga aaaatatttt taagtgttct aaaaataaaa gtattgaatt aaagtgaaaa 1440 aaaa 1444 <210> SEQ ID NO 54 <211> LENGTH: 3189 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 54 agcgggcggg actgccgggt gatgagatac tcggtcggcg acggtagaac gggcgacggc 60 gacaaccgca atcacatcca cgacggtgat catggcagag aatcacgccc agaataaagc 120 caagctcatc tctgagaccc ggaggaggtt cgaagctgag tatgtgacag ataagtcaga 180 taaatatgat gcacgtgatg ttgaaaggct acaacaagat gataactggg ttgaaagtta 240 cttatcttgg agacataata ttgtagatga aacactgaag atgctcgatg agagttttca 300 gtggaggaaa gaaatttctg tcaatgacct taatgaatcc tccattccca gatggttatt 360 ggaaattggt gttatttatc tccatggtta tgacaaagaa ggtaacaaat tgttctggat 420 cagggtgaag tatcatgtaa aagaccagaa aaccatattg gacaaaaaga agctcatagc 480 attctggttg gaacgttatg ctaagaggga aaatgggaaa cctgtaacag tgatgtttga 540 cctgtcagaa actggaataa atagcattga catggacttt gtacgcttta tcatcaactg 600 ctttaaggtt tattacccta aatacctctc aaaaatagtg atctttgata tgccttggtt 660 aatgaatgct gctttcaaaa ttgtgaaaac ctggcttggt ccagaagcag tgagcttgtt 720 gaagtttaca agcaaaaatg aagtccagga ctatgtcagt gtagaatacc tgcctcccca 780 catgggtgga actgatcctt tcaagtatag ctatccacca ctagtagatg atgacttcca 840 gaccccactg tgtgagaatg ggcctattac cagtgaggat gaaacttcaa gtaaagaaga 900 catagaaagt gatggcaaag aaacattgga aacaatttct aatgaagaac aaacacctct 960 tcttaaaaag attaacccaa ccgaatctac ttccaaagca gaagaaaatg aaaaagttga 1020 ttcaaaagtg aaagctttca agaaaccatt gagtgtattt aaaggcccct tactacacat 1080 cagcccagca gaagaactgt actttggaag tacagaatcc ggagagaaga aaaccttaat 1140 agtgttgaca aatgtaacta aaaatatagt ggcatttaag gtgagaacaa cagctccaga 1200 aaaatacaga gtcaagccaa gcaatagcag ctgtgacccg ggtgcatcag tggatatagt 1260 tgtgtctccc catgggggtt taacagtctc tgcccaagac cgttttctga taatggctgc 1320 agaaatggaa cagtcatctg gcacaggccc agcagaatta actcagtttt ggaaagaagt 1380 tcccagaaac aaagtgatgg aacataggtt aagatgccat actgttgaaa gcagtaaacc 1440 aaacactctt acgttaaaag acaatgcttt caatatgtca gataaaacca gtgaagatat 1500 atgtctacaa ctcagtcgtt tactagaaag caataggaag cttgaagacc aagttcagcg 1560 ttgtatctgg ttccagcagc tgctgctttc cttaacaatg ctcttgcttg cttttgtcac 1620 ctctttcttc tatttattgt acagttaaag aagtggtgcc gggtaggaac cacggttcct 1680 tcgtccatta gttggaaaaa gtaacagacc taaaactcta ccaagctact aaaaacattg 1740 cacatctgtg cttcctaaaa ggaaatatgc agcacgtgga ggggaacaca tacatgtctt 1800 gaaaataaac tgctagaata aagaaatgct ggagaaattg attataagag actatagcta 1860 tttagtaaag taagtaaagg catatccatt gtgtaaatta atagtttaaa tataatttat 1920 tttttccttt tgatctgaat acttttaaag cttaagtttt atcgtgtaaa tacattagct 1980 aaactgaaaa gtataagtaa catgctttgt tgcagccaaa aaatgtaatc tgctttttta 2040 tgacagaatt attatagctg agctgactta ctagcttttc tatactatgt atatagaaga 2100 acatgtatat tgagaaagaa aacatactta tatagaggaa tttatgtaac catgactttg 2160 taattttgag aattcctccc agtgatggtc agtattcttt tggaatgtaa accgatttaa 2220 tgccaaacca ccttaacctt tgtttctcag tgttccttaa cagcctgcct tttattaatc 2280 tcaggttttt ttatgaacac tctcatttca gtagaatttg gaaaactaag cgtggttgga 2340 atttctttga attctgttag taatgcccaa aagaaaagtc tcaagcagtc cccctatcca 2400 gtcattttta tggagtttca tgttgtccac tatagctgga cactgaacct tttgcctaat 2460 ttattataaa ggcctgaccc tctattgtcc catcttcacc cccattccag agcagaggag 2520 tctctgtgga ccatgaattg cactgtctcc ctcctcattt ctaaatgaaa ggtattagat 2580 ataaattttt ttgaaaggtt agttgtttga gatgctaagc aggataataa atttagattt 2640 taaaatgttc cctgtaaaag tcagcccatg acaaggaaat ttacaaaata ctagagtatc 2700 tagaagggtg aaaacaaaaa aaaataaaaa gaaacacaga cgcccaggtg tcagctctcc 2760 gtttaaagaa tgaaaaatgt aactcatgat gatctgtgaa accttcaaac taggaccaat 2820 tgacttactt gatattctgc ctttgatatg gtagtaccca cccggtattc ctaaaatcct 2880 aaaaagatac accttgcagt agcagaggca atgacatgag tttgttttct cattaatatg 2940 accagtttgg gtctatgttg gttcacatgt acatctactt tatatgaaag aaaaaacagt 3000 tgtctgcctg taaaatgttg agtttcgatt gagccatgtt tggagatttt attactattc 3060 tgaagggtag tgttgttggt tttcatcttc aagaagttga ttccaaaact gagttatgaa 3120 gaatgatata acagttcctt caaaattggc ctaggaaata aaaccttaaa aggaaaaaaa 3180 aaaaaaaaa 3189 <210> SEQ ID NO 55 <211> LENGTH: 2266 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 55 agcggagcag tagccaccac tccgccgagg ccgcaacccc ggctcggcct ccccaggccc 60 cgccgctgcc gcagtcatgg ctgctgatgg ggtggacgaa cgctcgcctc tgctgtcagc 120 atcccactcc ggaaatgtca ctcccaccgc cccaccgtac ttgcaagaaa gcagccccag 180 agcggagctc ccacctccat atacagccat tgccagtcca gacgccagtg gtattccagt 240 aataaactgc cgtgtgtgcc aatcactaat caatttggat ggcaagcttc accagcatgt 300 ggttaagtgc acagtttgca atgaagctac gccaatcaaa aaccccccaa caggcaagaa 360 atatgttaga tgcccttgta attgtcttct catttgtaag gacacatctc ggcgaatagg 420 atgcccaaga cccaactgta gacggataat taaccttggc ccagtaatgc ttatttctga 480 agaacaacca gctcagcctg cattgccaat ccaaccagaa ggtacaaggg tcgtgtgtgg 540 gcactgtgga aacacattcc tgtggatgga actgaggttc aacactctgg caaaatgccc 600 acactgcaaa aaaatctcct cagtgggtag tgcacttcca cgaagacgct gctgtgcata 660 tattaccatt ggaatgatat gtattttcat tggagttggg ttaactgttg gcaccccaga 720 ttttgcaagg cgatttcgag caacctatgt ttcttgggca attgcttatc tcctaggatt 780 gatctgcctt atccgagctt gttattgggg agccataaga gtcagttatc cagaacacag 840 ttttgcataa gcttgtttat gattcagtaa tgcaggtgag agtgtctagc agttcttggt 900 aagctactct ggacatcttt aaattattta tcctaatgga ttccattctg gtttatgtat 960 aatcgtttca agactttggg agtcttttat gaacaaatgc tcattgcact atattatatg 1020 caaattgttt tgctgctagg ttttcaaaat ttgaataata aagccttttc atgttctttt 1080 acatctctta tagatatttt tggatttgtt accaaacatt acatttactc tcaccctttt 1140 attattttta aataagttat ttcattactt gctgatacat gagtattcct aagtgtttat 1200 aaatatttct ataatagttt cacatttata tttacatttt aattaaacag tatcaaaatt 1260 gcttgcttaa aacctaagca atatgcattt tgcttgaact gcttactgta actttaacct 1320 aagattatag tgaccttatt caggaaaaaa aaaaaattta gtgtaacttc aaagacttga 1380 cattcttgtc agaggaaaaa aaatttctag atactgtttg cttgtttttt gttgtttgta 1440 gaaagataaa atattttggt aataatttaa aatacaagaa cgaatattta tttgtccaca 1500 gttggagatg ttggataaat gtcttttctc aaagatcaca ggacttttgt ctttcatttt 1560 tgccttttta tttaccattt ataaaagatc tggtctggat tatggaattt aatgtttatc 1620 agctctatgt attcctttat agaggcttga ggaagtattt cacataacat gttttataat 1680 acttaaccat ttatccaaag atatatttac attgggttgt gcccctttcc cttagatcat 1740 ggtaaatttt tcttattgag gtaattatgt actacttata tttgaaggaa gcttatgaca 1800 ttttacagta gctaaaatgt tgagattaga ggtactttta ctattcttct caaaggtaac 1860 tgatcagata attacccaaa ttattcaaga aaatagatca gaaataaaga acaacataat 1920 tttctaagaa ttcattgaaa tttatggaat cagctctcgc actgcccatc tttgcagttt 1980 tgaaaaagaa attgcttaat cacaaatgtt ctacagtctt taaatgtagt agaattagac 2040 agtgagatca tctgagtaaa ttgattggtg attccagaga taagactaat attttaaatt 2100 atttatgata ctgattagta taaaaacgta ctcatcacag aatttgaagc aaaatacatg 2160 tacacttcaa agagtaaatg acaaatgtat aaatgctgta gctcaggatt atatgtacct 2220 ttaaaaatac actaataaag attattgttc aaaaaaaaaa aaaaaa 2266 <210> SEQ ID NO 56 <211> LENGTH: 3234 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 56 gtttgcattt ctaatgacag tgaactgaca aagcgtgaaa gtggtctaag gagcaaaaca 60 aagccagcaa gcctgcttct ggtgtgccaa gattaatcaa tattccagaa acctcgggtt 120 tcccctcctc cctgtgcggt ttccattccc cactcctcct ttcccgggca cagactcctc 180 cctctcttct taagttgccc tgatagtaac ttgcagtttc agagcacatg cacactgtca 240 ggctagcctg cctgcttacg cgcgctgcgg attgttgctc cgttgtacct gctgggaatt 300 cacctcgtta ctgcttgata tcttccaccc cttacaaaat cagaaaaggt aagtgtcaca 360 ttctgtgttc ctgctgggtt taatttctcc tttcacttct ctgccgatgt atttgccttc 420 caagcagagg agtagcctga atcaaggcta gccattttgg tagataaagt ccttgttagt 480 catctcacgt cgtgagagtg tggtgctgtt tatgccggtc gctgttaatt cggagttgag 540 tcattcgggg tggattgggg gcagattgtg gcgcgagatc tagaaaaagg atcaaggttg 600 agcggatctg cttaaaagtg actggtaaga ggaatcagag ctattagttt aaaaaaaaaa 660 aaattccttg ggtccttcct tcccttattt cccggtcttc cacttctccc taagcattta 720 atccagtgtg aagtcttaaa caaattagaa gtcttagtat cactgacccc aacttgcaat 780 tttatttaaa aggcaaactg ttaagacaag tctttttttt tcctgcactg ggattgcgag 840 aagtcatttg cgaggagtcc tttggtttcc agttacctcc ccacaggcgc acacgctggc 900 tgcttgcgtt ggcagcgaca cacatccatg gtacggctgg ttttcactcg gattgattat 960 gggaagggct atggattaga gctcctgtaa agcaccaagg aggaatccct tgatttttca 1020 gaacagctga tttccaccag gaaagagatt tactgaaatg tagttaaata gcgtgagtgc 1080 tttaaagaaa ccagaaacca caagctgtaa tgtttggaat gaaaattggt ttcatctcat 1140 ctgttctaga aatcctaaat tttaaaacgc taaaaagtca gcgatagttt ctcggaagat 1200 tccagcatgt gtgtcacaaa gaaaaacact acttcatact tctacttgtg ataaacgaag 1260 ctgaattgtg atttcagatg atttatagat gtgcccagag cactttgctt atttcatgga 1320 aaaaaaatga aaaaattacc ctgtaaaata gtcacatgta tttcccatgt actgtgggca 1380 cttgtgttct ttttatgacc atatttacta gtagatatta ttatattttt tcttaatgaa 1440 gaaaatagct ggttacttta ctgcatgtaa cagagacaac tcccacctat cagtatctta 1500 attattttta ttgacctggt tatgctttca accatgtata cagcataatt tgtcaagtaa 1560 tgattgaata ctttctgtgc attcagttca attggacatt tactgattgt gtacgttgtg 1620 caaggcatca gctgggttct gcgggggagg gtgggaatag gggttctcag tcagatctag 1680 ctctgaagaa cccttttata gcctcattgg aaggggaagg acggattttt aaaaagaaaa 1740 tagaatatat tccgaattta tgcacatttc tcacacgtgg tccactaaaa tatgcacact 1800 gcaaccttga ggtctggtat tgtggctctc cagtccttga ttcctgctga gattatgcaa 1860 tttgccaaga gcttgcctgg tgtggagcag cactgatttc tcacccctgg aggctataac 1920 tcatgtctct ttttctccca ttctagttgt gttttctaat accaaagagg aggtttggct 1980 ttctgtgggt gattcccaga cactgaagtg caaagaagag accctcctag aaaagtaaaa 2040 tatgactaaa agcaatggag aagagcccaa gatggggggc aggatggaga gattccagca 2100 gggagtccgt aaacgcacac ttttggccaa gaagaaagtg cagaacatta caaaggagga 2160 tgttaaaagt tacctgtttc ggaatgcttt tgtgctgctc acagtcaccg ctgtcattgt 2220 gggtgagtca tttgattaaa aacaaaaaaa cctgtatctt gtttctctgg ggcatctggc 2280 tgcccgggga atattatcag atgaactagt tgtaggtatc aaaatggtag cctaggcttt 2340 cctctgaact tgatgatttt tctccataaa aatgactgtt ttggcttgtt tggagcaata 2400 tatagtaaac acatcattag gcatcattag gcatcattag gcattatgca aatcaattgt 2460 gtgaggaaga aaataaataa aatattttcc catttcatgt aaggataagg aagtgatcat 2520 ttaatcatta ggcatgacaa agcaagcatg ctagatttgg ccaaaatgta attatataca 2580 atgtcagttg cacttaaaac taatttatac aattagtaca cctaaaatga catgttggtt 2640 ccaaatagta attatattct aactggtgct gacttgaagc tgagtatcaa cgcttaggca 2700 cagagaccga atattttatg tgtttgcact ctctcaccca gcaactggga aaggtagatt 2760 ggggaaaatg ttaacacaga tctctttcat tcattgcttt gcagagcctg ccataaccag 2820 ctataccttt ttttgaatca tttccatctc ttactaattt agcagggttg acagcaatct 2880 gtactaataa aatattattg ttttgttttg tttattgatc ttaaaagtta tagtttatta 2940 cttatgggtg gcattgatcc tactttaaaa tatagctgaa aaaacctact tatttggaat 3000 tttgaccaac caatacagaa tccttagatt gacaacatat acgccaatgc caggttgtaa 3060 atattccaac ttaacctacc aatttgccac caaaaaagag gcattcagta ccgttttaat 3120 ctctactttg gagtttgcca agatttccat caactttaaa gaggtaatga tttaataaag 3180 attaagaaaa ttctgtagtg tgtaaatata acttttttca agaaaattga attc 3234 <210> SEQ ID NO 57 <211> LENGTH: 3331 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 57 cagagggcac cgcccaggcc tcggaaggtg tcagggagaa ctttccgtgg tttcagcgtc 60 gtcgcctgga gcggcggttt agagagccga gcctgatggg cgccaaggcc ggctggctgc 120 ttggagcgct gcctcgaagg gactgcgtaa ggaagctaat ccggagaacc caggccagag 180 cctgaaatat ggcgacctgc atcggggaga agatcgagga ttttaaagtt ggaaatctgc 240 ttggtaaagg atcatttgct ggtgtctaca gagctgagtc cattcacagt ggtttggaag 300 ttgcaatcaa aatgatagat aagaaagcca tgtacaaagc aggaatggta cagagagtcc 360 aaaatgaggt gaaaatacat tgccaattga aacatccttc tatcttggag ctttataact 420 attttgaaga tagcaattat gtgtatctgg tattagaaat gtgccataat ggagaaatga 480 acaggtatct aaagaataga gtgaaaccct tctcagaaaa tgaagctcga cacttcatgc 540 accagatcat cacagggatg ttgtatcttc attctcatgg tatactacac cgggacctca 600 cactttctaa cctcctactg actcgtaata tgaacatcaa gattgctgat tttgggctgg 660 caactcaact gaaaatgcca catgaaaagc actatacatt atgtggaact cctaactaca 720 tttcaccaga aattgccact cgaagtgcac atggccttga atctgatgtt tggtccctgg 780 gctgtatgtt ttatacatta cttatcggga gaccaccctt cgacactgac acagtcaaga 840 acacattaaa taaagtagta ttggcagatt atgaaatgcc aacttttttg tcaatagagg 900 ccaaggacct tattcaccag ttacttcgta gaaatccagc agatcgttta agtctgtctt 960 cagtattgga ccatcctttt atgtcccgaa attcttcaac aaaaagtaaa gatttaggaa 1020 ctgtggaaga ctcaattgat agtgggcatg ccacaatttc tactgcaatt acagcttctt 1080 ccagtaccag tataagtggt agtttatttg acaaaagaag acttttgatt ggtcagccac 1140 tcccaaataa aatgactgta tttccaaaga ataaaagttc aactgatttt tcttcttcag 1200 gagatggaaa cagtttttat actcagtggg gaaatcaaga aaccagtaat agtggaaggg 1260 gaagagtaat tcaagatgca gaagaaaggc cacattctcg ataccttcgt agagcttatt 1320 cctctgatag atctggcact tctaatagac agtctcaagc aaaaacatat acaatggaac 1380 gatgtcactc agcagaaatg ctttcagtgt ccaaaagatc aggaggaggt gaaaatgaag 1440 agaggtactc acccacagac aacaatgcca acatttttaa cttctttaaa gaaaagacat 1500 ccagtagttc tggatctttt gaaagacctg ataacaatca agcactctcc aatcatcttt 1560 gtccaggaaa aactcctttt ccatttgcag acccgacacc tcagactgaa accgtacaac 1620 agtggtttgg gaatctgcaa ataaatgctc atttaagaaa aactactgaa tatgacagca 1680 tcagcccaaa ccgggacttc cagggccatc cagatttgca gaaggacaca tcaaaaaatg 1740 cctggactga tacaaaagtc aaaaagaact ctgatgcttc tgataatgca cattctgtaa 1800 aacagcaaaa taccatgaaa tatatgactg cacttcacag taaacctgag ataatccaac 1860 aagaatgtgt ttttggctca gatcctcttt ctgaacagag caagactagg ggtatggagc 1920 caccatgggg ttatcagaat cgtacattaa gaagcattac atctccgttg gttgctcaca 1980 ggttaaaacc aatcagacag aaaaccaaaa aggctgtggt gagcatactt gattcagagg 2040 aggtgtgtgt ggagcttgta aaggagtatg catctcaaga atatgtgaaa gaagttcttc 2100 agatatctag tgatggaaat acgatcacta tttattatcc aaatggtggt agaggttttc 2160 ctcttgctga tagaccaccc tcacctactg acaacatcag taggtacagc tttgacaatt 2220 taccagaaaa atactggcga aaatatcaat atgcttccag gtttgtacag cttctaagat 2280 ctaaatctcc caaaatcact tattttacaa gatatgctaa atgcattttg atggagaatt 2340 ctcctggtgc tgattttgag gtttggtttt atgatggggt aaaaatacac aaaacagaag 2400 atttcattca ggtgattgaa aagacaggga agtcttacac tttaaaaagt gaaagtgaag 2460 ttaatagctt gaaagaggag ataaaaatgt atatggacca tgctaatgag ggtcatcgta 2520 tttgtttagc actggaatcc ataatttcag aagaggaaag gaaaactagg agtgctccct 2580 ttttcccaat aatcatagga agaaaacctg gtagtactag ttcacctaag gccttatcac 2640 ctcctccttc tgtggattca aattacccaa cgagagatag agcatctttc aacagaatgg 2700 tcatgcatag tgatgcttct ccaacacagg caccaatcct taatccctct atggttacaa 2760 atgaaggact tggtcttaca actacagctt ctggaacaga catctcttct aatagtctaa 2820 aagattgtct tcctaaatca gcacaacttt tgaaatctgt ttttgtgaaa aatgttggtt 2880 gggctacaca gttaactagt ggagctgtgt gggttcagtt taatgatggg tcccagttgg 2940 ttgtgcaggc aggagtgtct tctatcagtt atacctcacc aaatggtcaa acaactaggt 3000 atggagaaaa tgaaaaatta ccagactaca tcaaacagaa attacagtgt ctgtcttcca 3060 tccttttgat gttttctaat ccgactccta attttcattg attaaaactc ctttcagaca 3120 tataagttta ataaataact tttttgttga ctttcaagta aagtgatttt ttttaattta 3180 acataaagtc ttcagaaagc ctttctatga aagaatttta acctataatg taaaccatgt 3240 atctgagata acaaagcaga atgaaacttg agtcacttac taaatatagt ggatataaaa 3300 tagaacacct gactttgctc ttagaccata a 3331 <210> SEQ ID NO 58 <211> LENGTH: 3007 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 58 gcccggagag ccgcatctat tggcagcttt gttattgatc agaaactgct cgccgccgac 60 ttggcttcca gtctggctgc gggcaaccct tgagttttcg cctctgtcct gtcccccgaa 120 ctgacaggtg ctcccagcaa cttgctgggg acttctcgcc gctcccccgc gtccccaccc 180 cctcattcct ccctcgcctt cacccccacc cccaccactt cgccacagct caggatttgt 240 ttaaaccttg ggaaactggt tcaggtccag gttttgcttt gatccttttc aaaaactgga 300 gacacagaag agggctctag gaaaaagttt tggatgggat tatgtggaaa ctaccctgcg 360 attctctgct gccagagcag gctcggcgct tccaccccag tgcagccttc ccctggcggt 420 ggtgaaagag actcgggagt cgctgcttcc aaagtgcccg ccgtgagtga gctctcaccc 480 cagtcagcca aatgagcctc ttcgggcttc tcctgctgac atctgccctg gccggccaga 540 gacaggggac tcaggcggaa tccaacctga gtagtaaatt ccagttttcc agcaacaagg 600 aacagaacgg agtacaagat cctcagcatg agagaattat tactgtgtct actaatggaa 660 gtattcacag cccaaggttt cctcatactt atccaagaaa tacggtcttg gtatggagat 720 tagtagcagt agaggaaaat gtatggatac aacttacgtt tgatgaaaga tttgggcttg 780 aagacccaga agatgacata tgcaagtatg attttgtaga agttgaggaa cccagtgatg 840 gaactatatt agggcgctgg tgtggttctg gtactgtacc aggaaaacag atttctaaag 900 gaaatcaaat taggataaga tttgtatctg atgaatattt tccttctgaa ccagggttct 960 gcatccacta caacattgtc atgccacaat tcacagaagc tgtgagtcct tcagtgctac 1020 ccccttcagc tttgccactg gacctgctta ataatgctat aactgccttt agtaccttgg 1080 aagaccttat tcgatatctt gaaccagaga gatggcagtt ggacttagaa gatctatata 1140 ggccaacttg gcaacttctt ggcaaggctt ttgtttttgg aagaaaatcc agagtggtgg 1200 atctgaacct tctaacagag gaggtaagat tatacagctg cacacctcgt aacttctcag 1260 tgtccataag ggaagaacta aagagaaccg ataccatttt ctggccaggt tgtctcctgg 1320 ttaaacgctg tggtgggaac tgtgcctgtt gtctccacaa ttgcaatgaa tgtcaatgtg 1380 tcccaagcaa agttactaaa aaataccacg aggtccttca gttgagacca aagaccggtg 1440 tcaggggatt gcacaaatca ctcaccgacg tggccctgga gcaccatgag gagtgtgact 1500 gtgtgtgcag agggagcaca ggaggatagc cgcatcacca ccagcagctc ttgcccagag 1560 ctgtgcagtg cagtggctga ttctattaga gaacgtatgc gttatctcca tccttaatct 1620 cagttgtttg cttcaaggac ctttcatctt caggatttac agtgcattct gaaagaggag 1680 acatcaaaca gaattaggag ttgtgcaaca gctcttttga gaggaggcct aaaggacagg 1740 agaaaaggtc ttcaatcgtg gaaagaaaat taaatgttgt attaaataga tcaccagcta 1800 gtttcagagt taccatgtac gtattccact agctgggttc tgtatttcag ttctttcgat 1860 acggcttagg gtaatgtcag tacaggaaaa aaactgtgca agtgagcacc tgattccgtt 1920 gccttgctta actctaaagc tccatgtcct gggcctaaaa tcgtataaaa tctggatttt 1980 tttttttttt tttgctcata ttcacatatg taaaccagaa cattctatgt actacaaacc 2040 tggtttttaa aaaggaacta tgttgctatg aattaaactt gtgtcgtgct gataggacag 2100 actggatttt tcatatttct tattaaaatt tctgccattt agaagaagag aactacattc 2160 atggtttgga agagataaac ctgaaaagaa gagtggcctt atcttcactt tatcgataag 2220 tcagtttatt tgtttcattg tgtacatttt tatattctcc ttttgacatt ataactgttg 2280 gcttttctaa tcttgttaaa tatatctatt tttaccaaag gtatttaata ttctttttta 2340 tgacaactta gatcaactat ttttagcttg gtaaattttt ctaaacacaa ttgttatagc 2400 cagaggaaca aagatgatat aaaatattgt tgctctgaca aaaatacatg tatttcattc 2460 tcgtatggtg ctagagttag attaatctgc attttaaaaa actgaattgg aatagaattg 2520 gtaagttgca aagacttttt gaaaataatt aaattatcat atcttccatt cctgttattg 2580 gagatgaaaa taaaaagcaa cttatgaaag tagacattca gatccagcca ttactaacct 2640 attccttttt tggggaaatc tgagcctagc tcagaaaaac ataaagcacc ttgaaaaaga 2700 cttggcagct tcctgataaa gcgtgctgtg ctgtgcagta ggaacacatc ctatttattg 2760 tgatgttgtg gttttattat cttaaactct gttccataca cttgtataaa tacatggata 2820 tttttatgta cagaagtatg tctcttaacc agttcactta ttgtactctg gcaatttaaa 2880 agaaaatcag taaaatattt tgcttgtaaa atgcttaata tcgtgcctag gttatgtggt 2940 gactatttga atcaaaaatg tattgaatca tcaaataaaa gaatgtggct attttgggga 3000 gaaaatt 3007 <210> SEQ ID NO 59 <211> LENGTH: 1002 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 59 Met Ala Ala His Glu Trp Asp Trp Phe Gln Arg Glu Glu Leu Ile Gly 1 5 10 15 Gln Ile Ser Asp Ile Arg Val Gln Asn Leu Gln Val Glu Arg Glu Asn 20 25 30 Val Gln Lys Arg Thr Phe Thr Arg Trp Ile Asn Leu His Leu Glu Lys 35 40 45 Cys Asn Pro Pro Leu Glu Val Lys Asp Leu Phe Val Asp Ile Gln Asp 50 55 60 Gly Lys Ile Leu Met Ala Leu Leu Glu Val Leu Ser Gly Arg Asn Leu 65 70 75 80 Leu His Glu Tyr Lys Ser Ser Ser His Arg Ile Phe Arg Leu Asn Asn 85 90 95 Ile Ala Lys Ala Leu Lys Phe Leu Glu Asp Ser Asn Val Lys Leu Val 100 105 110 Ser Ile Asp Ala Ala Glu Ile Ala Asp Gly Asn Pro Ser Leu Val Leu 115 120 125 Gly Leu Ile Trp Asn Ile Ile Leu Phe Phe Gln Ile Lys Glu Leu Thr 130 135 140 Gly Asn Leu Ser Arg Asn Ser Pro Ser Ser Ser Leu Ser Pro Gly Ser 145 150 155 160 Gly Gly Thr Asp Ser Asp Ser Ser Phe Pro Pro Thr Pro Thr Ala Glu 165 170 175 Arg Ser Val Ala Ile Ser Val Lys Asp Gln Arg Lys Ala Ile Lys Ala 180 185 190 Leu Leu Ala Trp Val Gln Arg Lys Thr Arg Lys Tyr Gly Val Ala Val 195 200 205 Gln Asp Phe Ala Gly Ser Trp Arg Ser Gly Leu Ala Phe Leu Ala Val 210 215 220 Ile Lys Ala Ile Asp Pro Ser Leu Val Asp Met Lys Gln Ala Leu Glu 225 230 235 240 Asn Ser Thr Arg Glu Asn Leu Glu Lys Ala Phe Ser Ile Ala Gln Asp 245 250 255 Ala Leu His Ile Pro Arg Leu Leu Glu Pro Glu Asp Ile Met Val Asp 260 265 270 Thr Pro Asp Glu Gln Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Glu 275 280 285 Arg Phe Pro Glu Leu Glu Ala Glu Asp Ile Phe Asp Ser Asp Lys Glu 290 295 300 Val Pro Ile Glu Ser Thr Phe Val Arg Ile Lys Glu Thr Pro Ser Glu 305 310 315 320 Gln Glu Ser Lys Val Phe Val Leu Thr Glu Asn Gly Glu Arg Thr Tyr 325 330 335 Thr Val Asn His Glu Thr Ser His Pro Pro Pro Ser Lys Val Phe Val 340 345 350 Cys Asp Lys Pro Glu Ser Met Lys Glu Phe Arg Leu Asp Gly Val Ser 355 360 365 Ser His Ala Leu Ser Asp Ser Ser Thr Glu Phe Met His Gln Ile Ile 370 375 380 Asp Gln Val Leu Gln Gly Gly Pro Gly Lys Thr Ser Asp Ile Ser Glu 385 390 395 400 Pro Ser Pro Glu Ser Ser Ile Leu Ser Ser Arg Lys Glu Asn Gly Arg 405 410 415 Ser Asn Ser Leu Pro Ile Lys Lys Thr Val His Phe Glu Ala Asp Thr 420 425 430 Tyr Lys Asp Pro Phe Cys Ser Lys Asn Leu Ser Leu Cys Phe Glu Gly 435 440 445 Ser Pro Arg Val Ala Lys Glu Ser Leu Arg Gln Asp Gly His Val Leu 450 455 460 Ala Val Glu Val Ala Glu Glu Lys Glu Gln Lys Gln Glu Ser Ser Lys 465 470 475 480 Ile Pro Glu Ser Ser Ser Asp Lys Val Ala Gly Asp Ile Phe Leu Val 485 490 495 Glu Gly Thr Asn Asn Asn Ser Gln Ser Ser Ser Cys Asn Gly Ala Leu 500 505 510 Glu Ser Thr Ala Arg His Asp Glu Glu Ser His Ser Leu Ser Pro Pro 515 520 525 Gly Glu Asn Thr Val Met Ala Asp Ser Phe Gln Ile Lys Val Asn Leu 530 535 540 Met Thr Val Glu Ala Leu Glu Glu Gly Asp Tyr Phe Glu Ala Ile Pro 545 550 555 560 Leu Lys Ala Ser Lys Phe Asn Ser Asp Leu Ile Asp Phe Ala Ser Thr 565 570 575 Ser Gln Ala Phe Asn Lys Val Pro Ser Pro His Glu Thr Lys Pro Asp 580 585 590 Glu Asp Ala Glu Ala Phe Glu Asn His Ala Glu Lys Leu Gly Lys Arg 595 600 605 Ser Ile Lys Ser Ala His Lys Lys Lys Asp Ser Pro Glu Pro Gln Val 610 615 620 Lys Met Asp Lys His Glu Pro His Gln Asp Ser Gly Glu Glu Ala Glu 625 630 635 640 Gly Cys Pro Ser Ala Pro Glu Glu Thr Pro Val Asp Lys Lys Pro Glu 645 650 655 Val His Glu Lys Ala Lys Arg Lys Ser Thr Arg Pro His Tyr Glu Glu 660 665 670 Glu Gly Glu Asp Asp Asp Leu Gln Gly Val Gly Glu Glu Leu Ser Ser 675 680 685 Ser Pro Pro Ser Ser Cys Val Ser Leu Glu Thr Leu Gly Ser His Ser 690 695 700 Glu Glu Gly Leu Asp Phe Lys Pro Ser Pro Pro Leu Ser Lys Val Ser 705 710 715 720 Val Ile Pro His Asp Leu Phe Tyr Phe Pro His Tyr Glu Val Pro Leu 725 730 735 Ala Ala Val Leu Glu Ala Tyr Val Glu Asp Pro Glu Asp Leu Lys Asn 740 745 750 Glu Glu Met Asp Leu Glu Glu Pro Glu Gly Tyr Met Pro Asp Leu Asp 755 760 765 Ser Arg Glu Glu Glu Ala Asp Gly Ser Gln Ser Ser Ser Ser Ser Ser 770 775 780 Val Pro Gly Glu Ser Leu Pro Ser Ala Ser Asp Gln Val Leu Tyr Leu 785 790 795 800 Ser Arg Gly Gly Val Gly Thr Thr Pro Ala Ser Glu Pro Ala Pro Leu 805 810 815 Ala Pro His Glu Asp His Gln Gln Arg Glu Thr Lys Glu Asn Asp Pro 820 825 830 Met Asp Ser His Gln Ser Gln Glu Ser Pro Asn Leu Glu Asn Ile Ala 835 840 845 Asn Pro Leu Glu Glu Asn Val Thr Lys Glu Ser Ile Ser Ser Lys Lys 850 855 860 Lys Glu Lys Arg Lys His Val Asp His Val Glu Ser Ser Leu Phe Val 865 870 875 880 Ala Pro Gly Ser Val Gln Ser Ser Asp Asp Leu Glu Glu Asp Ser Ser 885 890 895 Asp Tyr Ser Ile Pro Ser Arg Thr Ser His Ser Asp Ser Ser Ile Tyr 900 905 910 Leu Arg Arg His Thr His Arg Ser Ser Glu Ser Asp His Phe Ser Tyr 915 920 925 Val Gln Leu Arg Asn Ala Ala Asp Leu Asp Asp Arg Arg Asn Arg Ile 930 935 940 Leu Thr Arg Lys Ala Asn Ser Ser Gly Glu Ala Met Ser Leu Gly Ser 945 950 955 960 His Ser Pro Gln Ser Asp Ser Leu Thr Gln Leu Val Gln Gln Pro Asp 965 970 975 Met Met Tyr Phe Ile Leu Phe Leu Trp Leu Leu Val Tyr Cys Leu Leu 980 985 990 Leu Phe Pro Gln Leu Asp Val Ser Arg Leu 995 1000 <210> SEQ ID NO 60 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 60 Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 1 5 10 15 Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 20 25 30 Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 35 40 45 Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 50 55 60 Ala Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp 65 70 75 80 Val Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala 85 90 95 Thr Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 100 105 <210> SEQ ID NO 61 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 61 Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 1 5 10 15 Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 20 25 30 Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 35 40 45 Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 50 55 60 Ala Gln Leu Gly Pro Leu Ser Pro Leu Pro Ile Cys Pro His Pro Cys 65 70 75 80 <210> SEQ ID NO 62 <211> LENGTH: 1357 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 62 Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile 1 5 10 15 Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr 20 25 30 Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile 35 40 45 Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys 50 55 60 Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val 65 70 75 80 Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln 85 90 95 Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg 100 105 110 Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln 115 120 125 Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu 130 135 140 Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala 145 150 155 160 Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp 165 170 175 Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu 180 185 190 Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys 195 200 205 Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp 210 215 220 Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala 225 230 235 240 Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys 245 250 255 Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys 260 265 270 Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu 275 280 285 Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val 290 295 300 Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys 305 310 315 320 Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu 325 330 335 Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys 340 345 350 Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg 355 360 365 Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu 370 375 380 Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu 385 390 395 400 Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu 405 410 415 Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala 420 425 430 Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu 435 440 445 Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu 450 455 460 Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu 465 470 475 480 Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg 485 490 495 Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu 500 505 510 Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu 515 520 525 Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln 530 535 540 Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg 545 550 555 560 Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu 565 570 575 Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile 580 585 590 Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val 595 600 605 Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala 610 615 620 Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile 625 630 635 640 Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala 645 650 655 Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln 660 665 670 Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln 675 680 685 Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn 690 695 700 Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu 705 710 715 720 Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys 725 730 735 Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu 740 745 750 Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile 755 760 765 Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala 770 775 780 Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys 785 790 795 800 Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu 805 810 815 Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln 820 825 830 Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val 835 840 845 Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu 850 855 860 Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys 865 870 875 880 Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp 885 890 895 Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln 900 905 910 Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe 915 920 925 Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg 930 935 940 Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr 945 950 955 960 Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln 965 970 975 Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro 980 985 990 Pro His Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile 995 1000 1005 Ser Gly Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu His 1010 1015 1020 Gln Arg Lys Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp Glu Ala Met 1025 1030 1035 1040 Glu Ala Leu Ala Ser Thr Glu Lys Met Leu Gln Asp Lys Val Asn Lys 1045 1050 1055 Thr Ser Lys Glu Arg Gln Gln Gln Val Glu Ala Val Glu Leu Glu Ala 1060 1065 1070 Lys Glu Val Leu Lys Lys Leu Phe Pro Lys Val Ser Val Pro Ser Asn 1075 1080 1085 Leu Ser Tyr Gly Glu Trp Leu His Gly Phe Glu Lys Lys Ala Lys Glu 1090 1095 1100 Cys Met Ala Gly Thr Ser Gly Ser Glu Glu Val Lys Val Leu Glu His 1105 1110 1115 1120 Lys Leu Lys Glu Ala Asp Glu Met His Thr Leu Leu Gln Leu Glu Cys 1125 1130 1135 Glu Lys Tyr Lys Ser Val Leu Ala Glu Thr Glu Gly Ile Leu Gln Lys 1140 1145 1150 Leu Gln Arg Ser Val Glu Gln Glu Glu Asn Lys Trp Lys Val Lys Val 1155 1160 1165 Asp Glu Ser His Lys Thr Ile Lys Gln Met Gln Ser Ser Phe Thr Ser 1170 1175 1180 Ser Glu Gln Glu Leu Glu Arg Leu Arg Ser Glu Asn Lys Asp Ile Glu 1185 1190 1195 1200 Asn Leu Arg Arg Glu Arg Glu His Leu Glu Met Glu Leu Glu Lys Ala 1205 1210 1215 Glu Met Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu Leu Lys Asp 1220 1225 1230 Leu Leu Thr Glu Leu Gln Lys Lys Leu Asp Asp Ser Tyr Ser Glu Ala 1235 1240 1245 Val Arg Gln Asn Glu Glu Leu Asn Leu Leu Lys Ala Gln Leu Asn Glu 1250 1255 1260 Thr Leu Thr Lys Leu Arg Thr Glu Gln Asn Glu Arg Gln Lys Val Ala 1265 1270 1275 1280 Gly Asp Leu His Lys Ala Gln Gln Ser Leu Glu Leu Ile Gln Ser Lys 1285 1290 1295 Ile Val Lys Ala Ala Gly Asp Thr Thr Val Ile Glu Asn Ser Asp Val 1300 1305 1310 Ser Pro Glu Thr Glu Ser Ser Glu Lys Glu Thr Met Ser Val Ser Leu 1315 1320 1325 Asn Gln Thr Val Thr Gln Leu Gln Gln Leu Leu Gln Ala Val Asn Gln 1330 1335 1340 Gln Leu Thr Lys Glu Lys Glu His Tyr Gln Val Leu Glu 1345 1350 1355 <210> SEQ ID NO 63 <211> LENGTH: 537 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 63 Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala 1 5 10 15 Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 20 25 30 Leu Phe Leu Asn Thr Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Thr 35 40 45 Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Thr Phe Ile 50 55 60 Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 65 70 75 80 Asp Ile Asp Asn Lys Thr Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 85 90 95 Glu Cys Glu Cys Thr Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Thr 100 105 110 Arg Pro Leu Val Met Lys Thr Gly Arg Pro Ala Gly Lys Gly Ser Ile 115 120 125 Thr Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 130 135 140 Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp 145 150 155 160 Pro Tyr Leu Glu Phe His Lys Gln Thr Ser Asp Gly Asn Trp Leu Met 165 170 175 Val His Arg Thr Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg 180 185 190 Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys 195 200 205 Thr Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp 210 215 220 Leu Ile Gly Thr Phe Gln Thr Thr Met Thr Lys Leu Lys Glu Ala Ser 225 230 235 240 Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln 245 250 255 Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys 260 265 270 Glu Ile Thr Val Glu Cys Thr Phe Leu Asp Tyr Ile Met Gly Gly Cys 275 280 285 Gln Leu Asn Phe Thr Val Gly Val Asp Phe Thr Gly Ser Asn Gly Asp 290 295 300 Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn 305 310 315 320 Glu Tyr Leu Thr Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr 325 330 335 Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro 340 345 350 Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser 355 360 365 Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser 370 375 380 Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Thr Asn Phe Ser Pro Ile 385 390 395 400 Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Thr Gln Gln Gln Thr 405 410 415 Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Thr Asp Gly Val Ile Thr 420 425 430 Asp Leu Asp Glu Thr Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro 435 440 445 Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met 450 455 460 Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu 465 470 475 480 Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln 485 490 495 Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro 500 505 510 Gln Gln Val Val Gly Tyr Phe Asn Thr Tyr Lys Leu Leu Pro Pro Lys 515 520 525 Asn Pro Ala Thr Lys Gln Gln Lys Gln 530 535 <210> SEQ ID NO 64 <211> LENGTH: 496 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 64 Met Ala Ser Ser Thr Gly Asp Arg Ser Gln Ala Val Arg His Gly Leu 1 5 10 15 Arg Ala Lys Val Leu Thr Leu Asp Gly Met Asn Pro Arg Val Arg Arg 20 25 30 Val Glu Tyr Ala Val Arg Gly Pro Ile Val Gln Arg Ala Leu Glu Leu 35 40 45 Glu Gln Glu Leu Arg Gln Gly Val Lys Lys Pro Phe Thr Glu Val Ile 50 55 60 Arg Ala Asn Ile Gly Asp Ala Gln Ala Met Gly Gln Arg Pro Ile Thr 65 70 75 80 Phe Leu Arg Gln Val Leu Ala Leu Cys Val Asn Pro Asp Leu Leu Ser 85 90 95 Ser Pro Asn Phe Pro Asp Asp Ala Lys Lys Arg Ala Glu Arg Ile Leu 100 105 110 Gln Ala Cys Gly Gly His Ser Leu Gly Ala Tyr Ser Val Ser Ser Gly 115 120 125 Ile Gln Leu Ile Arg Glu Asp Val Ala Arg Tyr Ile Glu Arg Arg Asp 130 135 140 Gly Gly Ile Pro Ala Asp Pro Asn Asn Val Phe Leu Ser Thr Gly Ala 145 150 155 160 Ser Asp Ala Ile Val Thr Val Leu Lys Leu Leu Val Ala Gly Glu Gly 165 170 175 His Thr Arg Thr Gly Val Leu Ile Pro Ile Pro Gln Tyr Pro Leu Tyr 180 185 190 Ser Ala Thr Leu Ala Glu Leu Gly Ala Val Gln Val Asp Tyr Tyr Leu 195 200 205 Asp Glu Glu Arg Ala Trp Ala Leu Asp Val Ala Glu Leu His Arg Ala 210 215 220 Leu Gly Gln Ala Arg Asp His Cys Arg Pro Arg Ala Leu Cys Val Ile 225 230 235 240 Asn Pro Gly Asn Pro Thr Gly Gln Val Gln Thr Arg Glu Cys Ile Glu 245 250 255 Ala Val Ile Arg Phe Ala Phe Glu Glu Arg Leu Phe Leu Leu Ala Asp 260 265 270 Glu Val Tyr Gln Asp Asn Val Tyr Ala Ala Gly Ser Gln Phe His Ser 275 280 285 Phe Lys Lys Val Leu Met Glu Met Gly Pro Pro Tyr Ala Gly Gln Gln 290 295 300 Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly Tyr Met Gly Glu Cys 305 310 315 320 Gly Phe Arg Gly Gly Tyr Val Glu Val Val Asn Met Asp Ala Ala Val 325 330 335 Gln Gln Gln Met Leu Lys Leu Met Ser Val Arg Leu Cys Pro Pro Val 340 345 350 Pro Gly Gln Ala Leu Leu Asp Leu Val Val Ser Pro Pro Ala Pro Thr 355 360 365 Asp Pro Ser Phe Ala Gln Phe Gln Ala Glu Lys Gln Ala Val Leu Ala 370 375 380 Glu Leu Ala Ala Lys Ala Lys Leu Thr Glu Gln Val Phe Asn Glu Ala 385 390 395 400 Pro Gly Ile Ser Cys Asn Pro Val Gln Gly Ala Met Tyr Ser Phe Pro 405 410 415 Arg Val Gln Leu Pro Pro Arg Ala Val Glu Arg Ala Gln Glu Leu Gly 420 425 430 Leu Ala Pro Asp Met Phe Phe Cys Leu Arg Leu Leu Glu Glu Thr Gly 435 440 445 Ile Cys Val Val Pro Gly Ser Gly Phe Gly Gln Arg Glu Gly Thr Tyr 450 455 460 His Phe Arg Met Thr Ile Leu Pro Pro Leu Glu Lys Leu Arg Leu Leu 465 470 475 480 Leu Glu Lys Leu Ser Arg Phe His Ala Lys Phe Thr Leu Glu Tyr Ser 485 490 495 <210> SEQ ID NO 65 <211> LENGTH: 2602 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 65 Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 1 5 10 15 Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 20 25 30 Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 35 40 45 Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 50 55 60 Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 65 70 75 80 Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 85 90 95 Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 100 105 110 Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 115 120 125 Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 130 135 140 Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 145 150 155 160 Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 165 170 175 Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 180 185 190 Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 195 200 205 Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 210 215 220 Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 225 230 235 240 Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 245 250 255 Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 260 265 270 Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 275 280 285 Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 290 295 300 Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 305 310 315 320 Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 325 330 335 His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 340 345 350 Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 355 360 365 Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 370 375 380 Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 385 390 395 400 Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 405 410 415 Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 420 425 430 Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 435 440 445 Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 450 455 460 Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 465 470 475 480 Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 485 490 495 Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 500 505 510 Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 515 520 525 Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 530 535 540 Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 545 550 555 560 Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 565 570 575 Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 580 585 590 Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 595 600 605 Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 610 615 620 Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 625 630 635 640 Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 645 650 655 Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 660 665 670 Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 675 680 685 Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 690 695 700 Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 705 710 715 720 Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 725 730 735 Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 740 745 750 Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 755 760 765 Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 770 775 780 Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 785 790 795 800 His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 805 810 815 Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 820 825 830 Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 835 840 845 Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 850 855 860 Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 865 870 875 880 Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 885 890 895 Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 900 905 910 Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 915 920 925 Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 930 935 940 Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 945 950 955 960 Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 965 970 975 Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 980 985 990 Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro 995 1000 1005 Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro 1010 1015 1020 Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro 1025 1030 1035 1040 Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly 1045 1050 1055 Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly 1060 1065 1070 Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser 1075 1080 1085 Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro 1090 1095 1100 Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly 1105 1110 1115 1120 Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val 1125 1130 1135 Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly 1140 1145 1150 Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu 1155 1160 1165 Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn 1170 1175 1180 Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly 1185 1190 1195 1200 Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe 1205 1210 1215 Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys 1220 1225 1230 Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr 1235 1240 1245 Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp 1250 1255 1260 His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys 1265 1270 1275 1280 Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro 1285 1290 1295 Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro 1300 1305 1310 Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro 1315 1320 1325 Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn 1330 1335 1340 Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly 1345 1350 1355 1360 Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg 1365 1370 1375 Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro 1380 1385 1390 Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly 1395 1400 1405 Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val 1410 1415 1420 Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu 1425 1430 1435 1440 Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu 1445 1450 1455 Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val 1460 1465 1470 Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu 1475 1480 1485 Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg 1490 1495 1500 Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val 1505 1510 1515 1520 Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu 1525 1530 1535 Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu 1540 1545 1550 Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val 1555 1560 1565 His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys 1570 1575 1580 Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro 1585 1590 1595 1600 Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys 1605 1610 1615 Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu 1620 1625 1630 Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val 1635 1640 1645 Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val 1650 1655 1660 Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys 1665 1670 1675 1680 Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro 1685 1690 1695 Asn Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val 1700 1705 1710 Glu Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val 1715 1720 1725 Thr Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe 1730 1735 1740 Lys Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile 1745 1750 1755 1760 Thr Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile 1765 1770 1775 Val Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu 1780 1785 1790 Val Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro 1795 1800 1805 Glu Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val 1810 1815 1820 Ser Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala 1825 1830 1835 1840 Thr Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu 1845 1850 1855 Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys 1860 1865 1870 Asp Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr 1875 1880 1885 Ser Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe 1890 1895 1900 Thr Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu 1905 1910 1915 1920 Gly Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser 1925 1930 1935 Ser Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys 1940 1945 1950 Leu Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro 1955 1960 1965 Arg Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His 1970 1975 1980 Val Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly 1985 1990 1995 2000 Asp Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg 2005 2010 2015 Thr Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr 2020 2025 2030 Gly Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln 2035 2040 2045 Thr Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr 2050 2055 2060 Val Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val 2065 2070 2075 2080 Pro Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys 2085 2090 2095 Glu Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly 2100 2105 2110 Ser Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp 2115 2120 2125 Met Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu 2130 2135 2140 Ile Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln 2145 2150 2155 2160 Glu Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val 2165 2170 2175 Thr Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly 2180 2185 2190 Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala 2195 2200 2205 Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly 2210 2215 2220 Gly Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe 2225 2230 2235 2240 Asp Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu 2245 2250 2255 Pro Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro 2260 2265 2270 Glu Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg 2275 2280 2285 Arg Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln 2290 2295 2300 Pro Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp 2305 2310 2315 2320 Ala Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser 2325 2330 2335 Glu Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn 2340 2345 2350 Gly Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly 2355 2360 2365 Ser Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro 2370 2375 2380 Ala Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly 2385 2390 2395 2400 Ile Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr 2405 2410 2415 Leu Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln 2420 2425 2430 Glu Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly 2435 2440 2445 Asn Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly 2450 2455 2460 Ser Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly 2465 2470 2475 2480 Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser 2485 2490 2495 Ser Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala 2500 2505 2510 Ser Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly 2515 2520 2525 Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met 2530 2535 2540 Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser 2545 2550 2555 2560 Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys 2565 2570 2575 Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile 2580 2585 2590 Pro Gly Ser Pro Phe His Val Thr Val Pro 2595 2600 <210> SEQ ID NO 66 <211> LENGTH: 686 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 66 Met Met Ile Gln Trp Asn Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala 1 5 10 15 Arg Gly Leu Ala Leu Thr Tyr Ser Leu Arg Asp Arg Glu Arg Gly Gly 20 25 30 Gly Arg Ala Gln Ile Gly Val Val Asp Asp Glu Ala Lys Ala Pro Asp 35 40 45 Leu Met Gln Ile Met Glu Ala Val Leu Gly Cys Arg Val Gly Ser Leu 50 55 60 Arg Ala Ala Thr Pro Ser Lys Asp Ile Asn Gln Leu Gln Lys Ala Asn 65 70 75 80 Val Arg Leu Tyr His Val Tyr Glu Lys Gly Lys Asp Leu Val Val Leu 85 90 95 Glu Leu Ala Thr Pro Pro Leu Thr Gln Asp Leu Leu Gln Glu Glu Asp 100 105 110 Phe Tyr Ile Leu Asp Gln Gly Gly Phe Lys Ile Tyr Val Trp Gln Gly 115 120 125 Arg Met Ser Ser Leu Gln Glu Arg Lys Ala Ala Phe Ser Arg Ala Val 130 135 140 Gly Phe Ile Gln Ala Lys Gly Tyr Pro Thr Tyr Thr Asn Val Glu Val 145 150 155 160 Val Asn Asp Gly Ala Glu Ser Ala Ala Phe Lys Gln Leu Phe Arg Thr 165 170 175 Trp Ser Glu Lys Arg Arg Arg Asn Gln Lys Leu Gly Gly Arg Asp Lys 180 185 190 Ser Ile His Val Lys Leu Asp Val Gly Lys Leu His Thr Gln Pro Lys 195 200 205 Leu Ala Ala Gln Leu Arg Met Val Asp Asp Gly Ser Gly Lys Val Glu 210 215 220 Val Trp Cys Ile Gln Asp Leu His Arg Gln Pro Val Asp Pro Lys Arg 225 230 235 240 His Gly Gln Leu Cys Ala Gly Asn Cys Tyr Leu Val Leu Tyr Thr Tyr 245 250 255 Gln Arg Leu Gly Arg Val Gln Tyr Ile Leu Tyr Leu Trp Gln Gly His 260 265 270 Gln Ala Thr Ala Asp Glu Ile Glu Ala Leu Asn Ser Asn Ala Glu Glu 275 280 285 Leu Asp Val Met Tyr Gly Gly Val Leu Val Gln Glu His Val Thr Met 290 295 300 Gly Ser Glu Pro Pro His Phe Leu Ala Ile Phe Gln Gly Gln Leu Val 305 310 315 320 Ile Phe Gln Glu Arg Ala Gly His His Gly Lys Gly Gln Ser Ala Ser 325 330 335 Thr Thr Arg Leu Phe Gln Val Gln Gly Thr Asp Ser His Asn Thr Arg 340 345 350 Thr Met Glu Val Pro Ala Arg Ala Ser Ser Leu Asn Ser Ser Asp Ile 355 360 365 Phe Leu Leu Val Thr Ala Ser Val Cys Tyr Leu Trp Phe Gly Lys Gly 370 375 380 Cys Asn Gly Asp Gln Arg Glu Met Ala Arg Val Val Val Thr Val Ile 385 390 395 400 Ser Arg Lys Asn Glu Glu Thr Val Leu Glu Gly Gln Glu Pro Pro His 405 410 415 Phe Trp Glu Ala Leu Gly Gly Arg Ala Pro Tyr Pro Ser Asn Lys Arg 420 425 430 Leu Pro Glu Glu Val Pro Ser Phe Gln Pro Arg Leu Phe Glu Cys Ser 435 440 445 Ser His Met Gly Cys Leu Val Leu Ala Glu Val Gly Phe Phe Ser Gln 450 455 460 Glu Asp Leu Asp Lys Tyr Asp Ile Met Leu Leu Asp Thr Trp Gln Glu 465 470 475 480 Ile Phe Leu Trp Leu Gly Glu Ala Ala Ser Glu Trp Lys Glu Ala Val 485 490 495 Ala Trp Gly Gln Glu Tyr Leu Lys Thr His Pro Ala Gly Arg Ser Pro 500 505 510 Ala Thr Pro Ile Val Leu Val Lys Gln Gly His Glu Pro Pro Thr Phe 515 520 525 Ile Gly Trp Phe Phe Thr Trp Asp Pro Tyr Lys Trp Thr Ser His Pro 530 535 540 Ser His Lys Glu Val Val Asp Gly Ser Pro Ala Ala Ala Ser Thr Ile 545 550 555 560 Ser Glu Ile Thr Ala Glu Val Asn Asn Leu Arg Leu Ser Arg Trp Pro 565 570 575 Gly Asn Gly Arg Ala Gly Ala Val Ala Leu Gln Ala Leu Lys Gly Ser 580 585 590 Gln Asp Ser Ser Glu Asn Asp Leu Val Arg Ser Pro Lys Ser Ala Gly 595 600 605 Ser Arg Thr Ser Ser Ser Val Ser Ser Thr Ser Ala Thr Ile Asn Gly 610 615 620 Gly Leu Arg Arg Glu Gln Leu Met His Gln Ala Val Glu Asp Leu Pro 625 630 635 640 Glu Gly Val Asp Pro Ala Arg Arg Glu Phe Tyr Leu Ser Asp Ser Asp 645 650 655 Phe Gln Asp Ile Phe Gly Lys Ser Lys Glu Glu Phe Tyr Ser Met Ala 660 665 670 Thr Trp Arg Gln Arg Gln Glu Lys Lys Gln Leu Gly Phe Phe 675 680 685 <210> SEQ ID NO 67 <211> LENGTH: 342 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 67 Met Ser Ser Ser Gly Thr Leu Ser Asn Tyr Tyr Val Asp Ser Leu Ile 1 5 10 15 Gly His Glu Gly Asp Glu Val Phe Ala Ala Arg Phe Gly Pro Pro Gly 20 25 30 Pro Gly Ala Gln Gly Arg Pro Ala Gly Val Ala Asp Gly Pro Ala Ala 35 40 45 Thr Ala Ala Glu Phe Ala Ser Cys Ser Phe Ala Pro Arg Ser Ala Val 50 55 60 Phe Ser Ala Ser Trp Ser Ala Val Pro Ser Gln Pro Pro Ala Ala Ala 65 70 75 80 Ala Met Ser Gly Leu Tyr His Pro Tyr Val Pro Pro Pro Pro Leu Ala 85 90 95 Ala Ser Ala Ser Glu Pro Gly Arg Tyr Val Arg Ser Trp Met Glu Pro 100 105 110 Leu Pro Gly Phe Pro Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 115 120 125 Gly Gly Pro Gly Arg Gly Pro Ser Pro Gly Pro Ser Gly Pro Ala Asn 130 135 140 Gly Arg His Tyr Gly Ile Lys Pro Glu Thr Arg Ala Ala Pro Ala Pro 145 150 155 160 Ala Thr Ala Ala Ser Thr Thr Ser Ser Ser Ser Thr Ser Leu Ser Ser 165 170 175 Ser Ser Lys Arg Thr Glu Cys Ser Val Ala Arg Glu Ser Gln Gly Ser 180 185 190 Ser Gly Pro Glu Phe Ser Cys Asn Ser Phe Leu Gln Glu Lys Ala Ala 195 200 205 Ala Ala Thr Gly Gly Thr Gly Pro Gly Ala Gly Ile Gly Ala Ala Thr 210 215 220 Gly Thr Gly Gly Ser Ser Glu Pro Ser Ala Cys Ser Asp His Pro Ile 225 230 235 240 Pro Gly Cys Ser Leu Lys Glu Glu Glu Lys Gln His Ser Gln Pro Gln 245 250 255 Gln Gln Gln Leu Asp Pro Asn Asn Pro Ala Ala Asn Trp Ile His Ala 260 265 270 Arg Ser Thr Arg Lys Lys Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu 275 280 285 Glu Leu Glu Lys Glu Phe Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg 290 295 300 Arg Tyr Glu Val Ala Arg Ile Leu Asn Leu Thr Glu Arg Gln Val Lys 305 310 315 320 Ile Trp Phe Gln Asn Arg Arg Met Lys Met Lys Lys Met Ser Lys Glu 325 330 335 Lys Cys Pro Lys Gly Asp 340 <210> SEQ ID NO 68 <211> LENGTH: 1719 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 68 Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 1 5 10 15 Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu 20 25 30 Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 35 40 45 Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr 50 55 60 Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 65 70 75 80 Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 85 90 95 Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 100 105 110 Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val 115 120 125 Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe 130 135 140 Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 145 150 155 160 Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 165 170 175 Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 180 185 190 His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 195 200 205 Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 210 215 220 Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr 225 230 235 240 Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 245 250 255 Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 260 265 270 Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val 275 280 285 Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 290 295 300 Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 305 310 315 320 Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 325 330 335 Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 340 345 350 Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr 355 360 365 Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met 370 375 380 Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val 385 390 395 400 Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 405 410 415 Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln 420 425 430 Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile 435 440 445 Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 450 455 460 Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro 465 470 475 480 Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 485 490 495 Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln 500 505 510 Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 515 520 525 Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg 530 535 540 Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 545 550 555 560 Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 565 570 575 Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Thr Glu Leu His Thr Gln 580 585 590 Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 595 600 605 Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Thr 610 615 620 Glu Arg Ala Lys Lys Glu Leu Glu Val His Thr Glu Ala Leu Ala Ala 625 630 635 640 Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 645 650 655 Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 660 665 670 Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys 675 680 685 Leu Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 690 695 700 Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 705 710 715 720 Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 725 730 735 Met Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser 740 745 750 Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 755 760 765 Lys Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp 770 775 780 Lys Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 785 790 795 800 Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 805 810 815 Trp Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 820 825 830 Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu 835 840 845 Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met 850 855 860 Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 865 870 875 880 Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 885 890 895 Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys 900 905 910 Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 915 920 925 Glu Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile 930 935 940 Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro 945 950 955 960 Thr Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser 965 970 975 Val His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly 980 985 990 Phe Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr 995 1000 1005 Thr Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile 1010 1015 1020 Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr 1025 1030 1035 1040 Cys Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr 1045 1050 1055 Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr 1060 1065 1070 Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp 1075 1080 1085 Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp 1090 1095 1100 Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val 1105 1110 1115 1120 Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser 1125 1130 1135 Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val 1140 1145 1150 Thr Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met 1155 1160 1165 Leu Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser 1170 1175 1180 Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val 1185 1190 1195 1200 Tyr Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr 1205 1210 1215 Thr Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn 1220 1225 1230 Glu Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg 1235 1240 1245 Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp 1250 1255 1260 Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe 1265 1270 1275 1280 Pro Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser 1285 1290 1295 Glu Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly 1300 1305 1310 Ala Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr 1315 1320 1325 Glu Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln 1330 1335 1340 Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys 1345 1350 1355 1360 Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly 1365 1370 1375 Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile 1380 1385 1390 Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys 1395 1400 1405 Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln 1410 1415 1420 Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser 1425 1430 1435 1440 Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala 1445 1450 1455 Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro 1460 1465 1470 Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu 1475 1480 1485 Gly Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu 1490 1495 1500 Gly Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln 1505 1510 1515 1520 Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro 1525 1530 1535 Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu 1540 1545 1550 Met Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala 1555 1560 1565 His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met 1570 1575 1580 Asn Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser 1585 1590 1595 1600 Ile Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser 1605 1610 1615 Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala 1620 1625 1630 Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro 1635 1640 1645 Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln 1650 1655 1660 Gly Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser 1665 1670 1675 1680 Pro Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro 1685 1690 1695 Ser Pro Ala Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr 1700 1705 1710 Asp Arg Gly Ser Trp Asp Pro 1715 <210> SEQ ID NO 69 <211> LENGTH: 1638 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 69 Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 1 5 10 15 Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu 20 25 30 Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 35 40 45 Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr 50 55 60 Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 65 70 75 80 Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 85 90 95 Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 100 105 110 Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val 115 120 125 Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe 130 135 140 Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 145 150 155 160 Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 165 170 175 Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 180 185 190 His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 195 200 205 Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 210 215 220 Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr 225 230 235 240 Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 245 250 255 Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 260 265 270 Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val 275 280 285 Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 290 295 300 Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 305 310 315 320 Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 325 330 335 Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 340 345 350 Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr 355 360 365 Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met 370 375 380 Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val 385 390 395 400 Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 405 410 415 Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln 420 425 430 Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile 435 440 445 Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 450 455 460 Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro 465 470 475 480 Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 485 490 495 Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln 500 505 510 Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 515 520 525 Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg 530 535 540 Glu Asp Leu Asn Lys Leu Glu Val His Thr Glu Ala Leu Ala Ala Glu 545 550 555 560 Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser Lys 565 570 575 Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser Tyr 580 585 590 Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys Leu 595 600 605 Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu Ser 610 615 620 Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu 625 630 635 640 Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met 645 650 655 Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser Glu 660 665 670 Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys 675 680 685 Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp Lys 690 695 700 Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu 705 710 715 720 Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp 725 730 735 Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp 740 745 750 Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu 755 760 765 Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met Pro 770 775 780 Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu 785 790 795 800 Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln 805 810 815 Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys Lys 820 825 830 Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu 835 840 845 Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu 850 855 860 His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro Thr 865 870 875 880 Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser Val 885 890 895 His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly Phe 900 905 910 Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr Thr 915 920 925 Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile Arg 930 935 940 Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr Cys 945 950 955 960 Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr Lys 965 970 975 Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr Glu 980 985 990 Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp Gln 995 1000 1005 Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp Ile 1010 1015 1020 Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val Ile 1025 1030 1035 1040 Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp 1045 1050 1055 Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val Thr 1060 1065 1070 Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met Leu 1075 1080 1085 Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser Glu 1090 1095 1100 Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val Tyr 1105 1110 1115 1120 Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr Thr 1125 1130 1135 Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn Glu 1140 1145 1150 Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg Val 1155 1160 1165 Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp Gln 1170 1175 1180 Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe Pro 1185 1190 1195 1200 Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser Glu 1205 1210 1215 Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly Ala 1220 1225 1230 Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr Glu 1235 1240 1245 Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln Val 1250 1255 1260 Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys Val 1265 1270 1275 1280 Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly Asn 1285 1290 1295 Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile Ala 1300 1305 1310 His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys Glu 1315 1320 1325 Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln Gly 1330 1335 1340 Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser Ser 1345 1350 1355 1360 Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala Val 1365 1370 1375 Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro Leu 1380 1385 1390 Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu Gly 1395 1400 1405 Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu Gly 1410 1415 1420 Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln Met 1425 1430 1435 1440 Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro Glu 1445 1450 1455 Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu Met 1460 1465 1470 Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala His 1475 1480 1485 Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met Asn 1490 1495 1500 Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser Ile 1505 1510 1515 1520 Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser Ala 1525 1530 1535 Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala Leu 1540 1545 1550 Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro Met 1555 1560 1565 Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln Gly 1570 1575 1580 Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser Pro 1585 1590 1595 1600 Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro Ser 1605 1610 1615 Pro Ala Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr Asp 1620 1625 1630 Arg Gly Ser Trp Asp Pro 1635 <210> SEQ ID NO 70 <211> LENGTH: 152 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met Ser His Val Leu Phe Ser Gly Arg Met Phe Ala Gly Leu Ala Gln 1 5 10 15 Asp Phe Arg Trp Ser Ala Ser Ser Phe Leu Ile Pro Cys Asp Cys Cys 20 25 30 Val Gly Lys Gln Arg Val Lys Cys Cys Arg Arg Thr Trp Glu Ser Phe 35 40 45 Cys Phe Glu Gly Pro Leu Glu Gln Glu Lys Leu Glu Ser Leu Ser Leu 50 55 60 Arg Ser Gln Asn Arg His Glu Asp Met Val Pro Ile Pro Leu Val Leu 65 70 75 80 Lys Gly Thr Pro Gly Glu Phe Gln Glu Thr Pro Pro Phe Leu Val Phe 85 90 95 Ile Leu Thr Pro Ser Pro Arg His Leu Ser Pro Gln Val His Thr Gln 100 105 110 Glu Gly Gly Ile Phe Tyr Leu Phe Arg Ser Gly Gln Gln Pro Val Gly 115 120 125 Asn Val Ile Ser Val Gly Thr Gly His Gly Thr Lys Pro Ser Trp Cys 130 135 140 Leu Asp Cys Asn Leu Ala Glu Ser 145 150 <210> SEQ ID NO 71 <211> LENGTH: 596 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 71 Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 1 5 10 15 Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 20 25 30 Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 35 40 45 Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 50 55 60 Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 65 70 75 80 Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 85 90 95 Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 100 105 110 Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr 115 120 125 Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln 130 135 140 Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile 145 150 155 160 Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro 165 170 175 Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn 180 185 190 Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro 195 200 205 Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro 210 215 220 Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Leu Val Pro Gln 225 230 235 240 Gln Gly Gln Pro Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro 245 250 255 Tyr Pro Thr Ala Leu Thr Val Asn Ala Ser Val Ser Arg Phe Pro Pro 260 265 270 His Met Val Pro Pro His His Thr Leu His Thr Thr Gly Ile Pro His 275 280 285 Pro Ala Ile Val Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp 290 295 300 Val Gly Ser Leu His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu 305 310 315 320 Glu Lys Lys Lys Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu 325 330 335 Tyr Met Lys Glu Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys 340 345 350 Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu 355 360 365 Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg 370 375 380 Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr 385 390 395 400 Gly Lys Lys Lys Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn 405 410 415 Glu His Ser Glu Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile 420 425 430 Thr Asp Leu Ser Ala Pro Lys Lys Cys Arg Ala Arg Phe Gly Leu Asp 435 440 445 Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys Cys Val 450 455 460 Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu Ser Pro Pro Ser Ser Asp 465 470 475 480 Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser Pro Asn Leu Leu Gly Ser 485 490 495 Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu Gln Thr Gln Pro Leu Ser 500 505 510 Leu Ser Leu Lys Pro Asp Pro Leu Ala His Leu Ser Met Met Pro Pro 515 520 525 Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr His Lys Ala Ser Ala Leu 530 535 540 Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro Ala Ala Leu Gln Pro Ala 545 550 555 560 Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser Thr Ser Trp Leu His Ser 565 570 575 His Ser Ser Leu Ala Gly Thr Gln Pro Gln Pro Leu Ser Leu Val Thr 580 585 590 Lys Ser Leu Glu 595 <210> SEQ ID NO 72 <211> LENGTH: 313 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 1 5 10 15 Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 20 25 30 Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 35 40 45 Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 50 55 60 Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 65 70 75 80 Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 85 90 95 Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 100 105 110 His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 115 120 125 Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 130 135 140 Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 145 150 155 160 Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 165 170 175 Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 180 185 190 Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 195 200 205 Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 210 215 220 Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 225 230 235 240 Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 245 250 255 Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 260 265 270 Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 275 280 285 Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 290 295 300 Ala Thr Ala Gly Thr Ala Ser Pro Pro 305 310 <210> SEQ ID NO 73 <211> LENGTH: 424 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 73 Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 1 5 10 15 Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 20 25 30 Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 35 40 45 Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 50 55 60 Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 65 70 75 80 Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 85 90 95 Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 100 105 110 Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 115 120 125 Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 130 135 140 Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn 145 150 155 160 Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp 165 170 175 Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe 180 185 190 Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln 195 200 205 Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val 210 215 220 Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile 225 230 235 240 Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly 245 250 255 Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala 260 265 270 Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala 275 280 285 Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu 290 295 300 Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly 305 310 315 320 Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val 325 330 335 Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala 340 345 350 Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro 355 360 365 Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala 370 375 380 Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg 385 390 395 400 Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala 405 410 415 Ala Val Phe Glu Tyr Pro Gly Asn 420 <210> SEQ ID NO 74 <211> LENGTH: 333 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 74 Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 1 5 10 15 Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 20 25 30 Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 35 40 45 Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 50 55 60 Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 65 70 75 80 Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 85 90 95 Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 100 105 110 Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 115 120 125 Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 130 135 140 Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 145 150 155 160 Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 165 170 175 Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 180 185 190 Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 195 200 205 Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 210 215 220 Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 245 250 255 Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 275 280 285 Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 290 295 300 Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 305 310 315 320 Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 325 330 <210> SEQ ID NO 75 <211> LENGTH: 545 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 75 Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 1 5 10 15 Met Arg Asn Thr Ser Thr Met Ile Gly Val Gly Ser Lys Asp Ala Gly 20 25 30 Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 35 40 45 Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 50 55 60 Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 65 70 75 80 Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 85 90 95 Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 100 105 110 Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 115 120 125 Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 130 135 140 Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 145 150 155 160 Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 165 170 175 Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 180 185 190 Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 195 200 205 Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 210 215 220 Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 225 230 235 240 Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 245 250 255 Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 260 265 270 Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 275 280 285 Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 290 295 300 Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 305 310 315 320 Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 325 330 335 Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 340 345 350 Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 355 360 365 Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 370 375 380 Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 385 390 395 400 Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 405 410 415 Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 420 425 430 Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp 435 440 445 Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr 450 455 460 Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly 465 470 475 480 Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp 485 490 495 Phe Leu Asn Arg Cys Leu Asp Met Asp Val Glu Lys Arg Gly Ser Ala 500 505 510 Lys Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser 515 520 525 Ser Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn 530 535 540 His 545 <210> SEQ ID NO 76 <211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 1 5 10 15 Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 20 25 30 Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 35 40 45 Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 50 55 60 Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 65 70 75 80 Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 85 90 95 Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 100 105 110 Ala Ala Lys 115 <210> SEQ ID NO 77 <211> LENGTH: 414 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 77 Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 1 5 10 15 Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 20 25 30 Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 35 40 45 Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 50 55 60 Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 65 70 75 80 Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 85 90 95 Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 100 105 110 Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 115 120 125 Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 130 135 140 Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 145 150 155 160 Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 165 170 175 Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 180 185 190 His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 195 200 205 Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 210 215 220 Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 225 230 235 240 Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 245 250 255 Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 260 265 270 Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 275 280 285 Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly 290 295 300 Val Ser Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu 305 310 315 320 Gln Gly Gln Ser Thr Ala Met Ala Ala Thr Gly Asp Val Ala Leu Leu 325 330 335 Arg His Ser Lys Leu Leu Ala Glu Pro Ala Gly Gly Leu Val Gly Glu 340 345 350 Arg Thr Cys Ser Ala Ser Pro Gly Cys Cys Gly Ser Met Met Gly Gln 355 360 365 Asp Ala Pro Trp Lys Ala Glu Ala Asp Ala Gly Gly Thr Ala Lys Leu 370 375 380 Pro His Gln Arg Leu Gly Cys Asn Ala Gly Val Ser Pro Ser Phe Gln 385 390 395 400 Gln His Cys Val Ala Ser Leu Ala Thr Lys Ala Ser Ser Gln 405 410 <210> SEQ ID NO 78 <211> LENGTH: 1043 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 1 5 10 15 Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr 20 25 30 Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile Ser Val 35 40 45 Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 50 55 60 Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 65 70 75 80 Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 85 90 95 Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 100 105 110 Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 115 120 125 Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 130 135 140 Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 145 150 155 160 Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 165 170 175 Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 180 185 190 Lys Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 195 200 205 Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 210 215 220 Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp Asp 225 230 235 240 Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 245 250 255 Ser Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 260 265 270 Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile 275 280 285 Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 290 295 300 Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 305 310 315 320 Thr Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 325 330 335 Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg 340 345 350 Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 355 360 365 Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 370 375 380 Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 385 390 395 400 Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu Glu 405 410 415 Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 420 425 430 Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 435 440 445 Ile Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 450 455 460 Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly 465 470 475 480 His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 485 490 495 Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 500 505 510 Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 515 520 525 Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu Arg 530 535 540 Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 545 550 555 560 Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 565 570 575 Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 580 585 590 Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 595 600 605 Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 610 615 620 Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 625 630 635 640 Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly 645 650 655 Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 660 665 670 Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 675 680 685 Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 690 695 700 Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 705 710 715 720 Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 725 730 735 Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 740 745 750 Phe Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 755 760 765 Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val 770 775 780 Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 785 790 795 800 Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 805 810 815 Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 820 825 830 Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu 835 840 845 Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 850 855 860 Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 865 870 875 880 Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 885 890 895 Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser Arg 900 905 910 Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 915 920 925 Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 930 935 940 Val Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 945 950 955 960 Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His Val 965 970 975 Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 980 985 990 Arg Gln Leu Thr Val Thr Val Thr Glu Lys Phe Ser Val Arg Phe Lys 995 1000 1005 Glu Asn Ser Val Ala Val Lys Val Val Gln Gly Pro Ala Gly Gly Asp 1010 1015 1020 Asn Ser Lys Leu Arg Tyr Lys Lys Lys Gly Ser His Cys Leu Glu Val 1025 1030 1035 1040 Thr Val Gln <210> SEQ ID NO 79 <211> LENGTH: 638 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Met Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu 1 5 10 15 Leu Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys 20 25 30 Lys Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu 35 40 45 Ile Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met 50 55 60 Glu Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg 65 70 75 80 Asp Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu 85 90 95 Arg Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu 100 105 110 Arg Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 115 120 125 Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg 130 135 140 Asp Arg Asp Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg 145 150 155 160 Asp Arg Asp Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys Asp Arg 165 170 175 Ser Arg Ser Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg Glu Arg 180 185 190 Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 195 200 205 Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys 210 215 220 Lys Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys 225 230 235 240 Leu Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu 245 250 255 Lys Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys 260 265 270 Glu Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala 275 280 285 Lys Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp 290 295 300 Pro Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg 305 310 315 320 Glu Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu 325 330 335 Glu Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp 340 345 350 Pro Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg 355 360 365 Gln Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu 370 375 380 Lys Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu 385 390 395 400 Glu Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser 405 410 415 Ser Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr 420 425 430 Pro Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser 435 440 445 Pro Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser 450 455 460 Leu Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys 465 470 475 480 Arg Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu 485 490 495 Asp Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr 500 505 510 Gly Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu 515 520 525 Lys Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys 530 535 540 Pro Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile 545 550 555 560 Leu Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu 565 570 575 Tyr Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys 580 585 590 Val Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met 595 600 605 Val Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu 610 615 620 Leu Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 625 630 635 <210> SEQ ID NO 80 <211> LENGTH: 940 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 1 5 10 15 Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 20 25 30 Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 35 40 45 Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 50 55 60 Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 65 70 75 80 Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 85 90 95 Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 100 105 110 Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 115 120 125 Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 130 135 140 Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 145 150 155 160 Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 165 170 175 Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 180 185 190 Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 195 200 205 Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 210 215 220 Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 225 230 235 240 Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 245 250 255 Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 260 265 270 Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 275 280 285 Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 290 295 300 Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 305 310 315 320 Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 325 330 335 Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 340 345 350 Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 355 360 365 Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 370 375 380 Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 385 390 395 400 Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 405 410 415 Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 420 425 430 Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 435 440 445 Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 450 455 460 Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 465 470 475 480 Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 485 490 495 Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 500 505 510 Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 515 520 525 Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 530 535 540 Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 545 550 555 560 Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 565 570 575 Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 580 585 590 Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 595 600 605 Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 610 615 620 Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 625 630 635 640 Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 645 650 655 Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 660 665 670 Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 675 680 685 Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 690 695 700 Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 705 710 715 720 Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 725 730 735 Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 740 745 750 Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 755 760 765 Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 770 775 780 Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 785 790 795 800 Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 805 810 815 Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 820 825 830 Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 835 840 845 Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 850 855 860 Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 865 870 875 880 Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 885 890 895 Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 900 905 910 Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 915 920 925 Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 930 935 940 <210> SEQ ID NO 81 <211> LENGTH: 953 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 81 Met Ala Glu Thr Leu Pro Gly Ser Gly Asp Ser Gly Pro Gly Thr Ala 1 5 10 15 Ser Leu Gly Pro Gly Val Ala Glu Thr Gly Thr Arg Arg Leu Ser Glu 20 25 30 Leu Arg Val Ile Asp Leu Arg Ala Glu Leu Lys Lys Arg Asn Leu Asp 35 40 45 Thr Gly Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys Lys Ala Val 50 55 60 Lys Glu Glu Gly Gln Asp Pro Asp Glu Ile Gly Ile Glu Leu Glu Ala 65 70 75 80 Thr Ser Lys Lys Ser Ala Lys Arg Cys Val Lys Gly Leu Lys Met Glu 85 90 95 Glu Glu Gly Thr Glu Asp Asn Gly Leu Glu Asp Asp Ser Arg Asp Gly 100 105 110 Gln Glu Asp Met Glu Ala Ser Leu Glu Asn Leu Gln Asn Met Gly Met 115 120 125 Met Asp Met Ser Val Leu Asp Glu Thr Glu Val Ala Asn Ser Ser Ala 130 135 140 Pro Asp Phe Gly Glu Asp Gly Thr Asp Gly Leu Leu Asp Ser Phe Cys 145 150 155 160 Asp Ser Lys Glu Tyr Val Ala Ala Gln Leu Arg Gln Leu Pro Ala Gln 165 170 175 Pro Pro Glu His Ala Val Asp Gly Glu Gly Phe Lys Asn Thr Leu Glu 180 185 190 Thr Ser Ser Leu Asn Phe Lys Val Thr Pro Asp Ile Glu Glu Ser Leu 195 200 205 Leu Glu Pro Glu Asn Glu Lys Ile Leu Asp Ile Leu Gly Glu Thr Cys 210 215 220 Lys Ser Glu Pro Val Lys Glu Glu Ser Ser Glu Leu Glu Gln Pro Phe 225 230 235 240 Ala Gln Asp Thr Ser Ser Val Gly Pro Asp Arg Lys Leu Ala Glu Glu 245 250 255 Glu Asp Leu Phe Asp Ser Ala His Pro Glu Glu Gly Asp Leu Asp Leu 260 265 270 Ala Ser Glu Ser Thr Ala His Ala Gln Ser Ser Lys Ala Asp Ser Leu 275 280 285 Leu Ala Val Val Lys Arg Glu Pro Ala Glu Gln Pro Gly Asp Gly Glu 290 295 300 Arg Thr Asp Cys Glu Pro Val Gly Leu Glu Pro Ala Val Glu Gln Ser 305 310 315 320 Ser Ala Ala Ser Glu Leu Ala Glu Ala Ser Ser Glu Glu Leu Ala Glu 325 330 335 Ala Pro Thr Glu Ala Pro Ser Pro Glu Ala Arg Asp Ser Lys Glu Asp 340 345 350 Gly Arg Lys Phe Asp Phe Asp Ala Cys Asn Glu Val Pro Pro Ala Pro 355 360 365 Lys Glu Ser Ser Thr Ser Glu Gly Ala Asp Gln Lys Met Ser Ser Phe 370 375 380 Lys Glu Glu Lys Asp Ile Lys Pro Ile Ile Lys Asp Glu Lys Gly Arg 385 390 395 400 Val Gly Ser Gly Ser Gly Arg Asn Leu Trp Val Ser Gly Leu Ser Ser 405 410 415 Thr Thr Arg Ala Thr Asp Leu Lys Asn Leu Phe Ser Lys Tyr Gly Lys 420 425 430 Val Val Gly Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Arg 435 440 445 Cys Tyr Gly Phe Val Thr Met Ser Thr Ser Asp Glu Ala Thr Lys Cys 450 455 460 Ile Ser His Leu His Arg Thr Glu Leu His Gly Arg Met Ile Ser Val 465 470 475 480 Glu Lys Ala Lys Asn Glu Pro Ala Gly Lys Lys Leu Ser Asp Arg Lys 485 490 495 Glu Cys Glu Val Lys Lys Glu Lys Leu Ser Ser Val Asp Arg His His 500 505 510 Ser Val Glu Ile Lys Ile Glu Lys Thr Val Ile Lys Lys Glu Glu Lys 515 520 525 Ile Glu Lys Lys Glu Glu Lys Lys Pro Glu Asp Ile Lys Lys Glu Glu 530 535 540 Lys Asp Gln Asp Glu Leu Lys Pro Gly Pro Thr Asn Arg Ser Arg Val 545 550 555 560 Thr Lys Ser Gly Ser Arg Gly Met Glu Arg Thr Val Val Met Asp Lys 565 570 575 Ser Lys Gly Glu Pro Val Ile Ser Val Lys Thr Thr Ser Arg Ser Lys 580 585 590 Glu Arg Ser Ser Lys Ser Gln Asp Arg Lys Ser Glu Ser Lys Glu Lys 595 600 605 Arg Asp Ile Leu Ser Phe Asp Lys Ile Lys Glu Gln Arg Glu Arg Glu 610 615 620 Arg Gln Arg Gln Arg Glu Arg Glu Ile Arg Glu Thr Glu Arg Arg Arg 625 630 635 640 Glu Arg Glu Gln Arg Glu Arg Glu Gln Arg Leu Glu Ala Phe His Glu 645 650 655 Arg Lys Glu Lys Ala Arg Leu Gln Arg Glu Arg Leu Gln Leu Glu Cys 660 665 670 Gln Arg Gln Arg Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu 675 680 685 Arg Glu Arg Met Arg Val Glu Arg Glu Arg Arg Lys Glu Gln Glu Arg 690 695 700 Ile His Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Glu Gln Leu Arg 705 710 715 720 Tyr Glu Gln Glu Arg Arg Pro Gly Arg Arg Pro Tyr Asp Leu Asp Arg 725 730 735 Arg Asp Asp Ala Tyr Trp Pro Glu Gly Lys Arg Val Ala Met Glu Asp 740 745 750 Arg Tyr Arg Ala Asp Phe Pro Arg Pro Asp His Arg Phe His Asp Phe 755 760 765 Asp His Arg Asp Arg Gly Gln Tyr Gln Asp His Ala Ile Asp Arg Arg 770 775 780 Glu Gly Ser Arg Pro Met Met Gly Asp His Arg Asp Gly Gln His Tyr 785 790 795 800 Gly Asp Asp Arg His Gly His Gly Gly Pro Pro Glu Arg His Gly Arg 805 810 815 Asp Ser Arg Asp Gly Trp Gly Gly Tyr Gly Ser Asp Lys Arg Leu Ser 820 825 830 Glu Gly Arg Gly Leu Pro Pro Pro Pro Arg Gly Gly Arg Asp Trp Gly 835 840 845 Glu His Asn Gln Arg Leu Glu Glu His Gln Ala Arg Ala Trp Gln Gly 850 855 860 Ala Met Asp Ala Gly Ala Ala Ser Arg Glu His Ala Arg Trp Gln Gly 865 870 875 880 Gly Glu Arg Gly Leu Ser Gly Pro Ser Gly Pro Gly His Met Ala Ser 885 890 895 Arg Gly Gly Val Ala Gly Arg Gly Gly Phe Ala Gln Gly Gly His Ser 900 905 910 Gln Gly His Val Val Pro Gly Gly Gly Leu Glu Gly Gly Gly Val Ala 915 920 925 Ser Gln Asp Arg Gly Ser Arg Val Pro His Pro His Pro His Pro Pro 930 935 940 Pro Tyr Pro His Phe Thr Arg Arg Tyr 945 950 <210> SEQ ID NO 82 <211> LENGTH: 5858 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (900)..(900) <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid <400> SEQUENCE: 82 Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 1 5 10 15 Met Leu Val Val Pro Gln Ala Glu Cys Thr Gly Arg Ser Pro Tyr Asp 20 25 30 Ser Leu Ser Val Leu Asp Gly Thr Leu Pro Val Pro Asn Thr Gly Leu 35 40 45 Trp Gly Pro Thr Gly Ser Gln Cys Gln Glu Thr Gln Gly Leu Ala Trp 50 55 60 Met Gly Cys Pro Gly Glu Glu Thr Gln Gly Pro Val Glu Pro Ser Trp 65 70 75 80 Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser Pro 85 90 95 Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser Leu 100 105 110 Ser Arg Lys Gln Met Leu Pro Leu Pro Ala Gly Lys Gly Val Phe Ala 115 120 125 Ser Pro Lys Gly Gly Gly Pro Asp Leu Gly Val Gln Leu Pro Pro Ala 130 135 140 Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp Gly Asp Phe 145 150 155 160 His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro Gly Leu Cys 165 170 175 Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu Asp Phe Asn 180 185 190 Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val Val Thr Arg 195 200 205 Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser Asn Gly Ser 210 215 220 Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser Arg Thr Gly 225 230 235 240 Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser Ile Arg Leu 245 250 255 Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu Leu Glu Leu 260 265 270 Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly Asp Phe Asn 275 280 285 Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala Arg Leu Thr 290 295 300 Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln 305 310 315 320 Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Pro 325 330 335 Pro Trp Met Ala Gly Val Pro Ser Leu Ala His Cys Ala Pro Gln Glu 340 345 350 Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His 355 360 365 Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu 370 375 380 Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg 385 390 395 400 Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu 405 410 415 Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly 420 425 430 Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys 435 440 445 Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu 450 455 460 Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys 465 470 475 480 Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr 485 490 495 Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu 500 505 510 Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr 515 520 525 Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu 530 535 540 Ser Lys Ser His Ile Pro His Met Gly Ile Pro Ser Thr Leu Leu Gly 545 550 555 560 Gly Thr Pro His His Arg Ala Arg Pro Asn Ala Arg Val Gly Pro Ser 565 570 575 Pro Gln Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg 580 585 590 Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu 595 600 605 Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly 610 615 620 Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn 625 630 635 640 Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly 645 650 655 Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met Gln Val Phe 660 665 670 Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly 675 680 685 Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val 690 695 700 Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala 705 710 715 720 Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser 725 730 735 Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp 740 745 750 Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro 755 760 765 Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu 770 775 780 Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala 785 790 795 800 Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr 805 810 815 Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala 820 825 830 Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser 835 840 845 Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe 850 855 860 Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys Pro Cys Tyr 865 870 875 880 Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His Asp Glu Gly 885 890 895 Ala Val Trp Xaa Gly Ser Gly Gly Lys Ala Gly Pro Pro Gly Cys Ala 900 905 910 Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro 915 920 925 Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe 930 935 940 Ser Thr His Cys Val Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser 945 950 955 960 Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His 965 970 975 Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn 980 985 990 Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys 995 1000 1005 Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp 1010 1015 1020 Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln 1025 1030 1035 1040 Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr 1045 1050 1055 Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile 1060 1065 1070 Lys Leu Phe Val Glu Val Arg Thr Ala Pro Ala Val Ser Thr Pro Asp 1075 1080 1085 Pro Ala Ala Asn Glu Pro Ala Pro Arg Glu Ala Ser Val Gly Phe Arg 1090 1095 1100 Gln Arg Leu Pro Pro Leu Gln Ser Tyr Glu Leu Ile Leu Gln Glu Gly 1105 1110 1115 1120 Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro Pro Tyr Lys 1125 1130 1135 Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His Gly Met Ala 1140 1145 1150 Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu His Gln Asp 1155 1160 1165 Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp Asp Asn Ala 1170 1175 1180 Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly Asp Ala Leu 1185 1190 1195 1200 Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro Asp Ala Leu 1205 1210 1215 Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys Ser Trp Ala 1220 1225 1230 Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala Ala Cys Arg 1235 1240 1245 Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val Asn Asp Ala 1250 1255 1260 Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys Thr Ala Val 1265 1270 1275 1280 Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys Val Ser Trp 1285 1290 1295 Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr Asn Pro His 1300 1305 1310 Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro Cys Leu Lys 1315 1320 1325 Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu Pro Gly Leu 1330 1335 1340 Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe Phe Asn Glu 1345 1350 1355 1360 Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp Lys Asp Gly 1365 1370 1375 Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu Asn Cys Gln 1380 1385 1390 Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His Ser Leu Glu 1395 1400 1405 Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr Gln Asp Val 1410 1415 1420 Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile Ala Ile Cys 1425 1430 1435 1440 Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys Pro Gly Thr 1445 1450 1455 Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val Pro His Ser 1460 1465 1470 Thr Thr Ser Pro Ala Leu Pro Val Ser Thr Val Cys Val Arg Glu Val 1475 1480 1485 Cys Arg Trp Ser Ser Trp Tyr Asn Gly His Arg Pro Glu Pro Gly Leu 1490 1495 1500 Gly Gly Gly Asp Phe Glu Thr Phe Glu Asn Leu Arg Gln Arg Gly Tyr 1505 1510 1515 1520 Gln Val Cys Pro Val Leu Ala Asp Ile Glu Cys Arg Ala Ala Gln Leu 1525 1530 1535 Pro Asp Met Pro Leu Glu Glu Leu Gly Gln Gln Val Asp Cys Asp Arg 1540 1545 1550 Met Arg Gly Leu Met Cys Ala Asn Ser Gln Gln Ser Pro Pro Leu Cys 1555 1560 1565 His Asp Tyr Glu Leu Arg Val Leu Cys Cys Glu Tyr Val Pro Cys Gly 1570 1575 1580 Pro Ser Pro Ala Pro Gly Thr Ser Pro Gln Pro Ser Leu Ser Ala Ser 1585 1590 1595 1600 Thr Glu Pro Ala Val Pro Thr Pro Thr Gln Thr Thr Ala Thr Glu Lys 1605 1610 1615 Thr Thr Leu Trp Val Thr Pro Ser Ile Arg Ser Thr Ala Ala Leu Thr 1620 1625 1630 Ser Gln Thr Gly Ser Ser Ser Gly Pro Val Thr Val Thr Pro Ser Ala 1635 1640 1645 Pro Gly Thr Thr Thr Cys Gln Pro Arg Cys Gln Trp Thr Glu Trp Phe 1650 1655 1660 Asp Glu Asp Tyr Pro Lys Ser Glu Gln Leu Gly Gly Asp Val Glu Ser 1665 1670 1675 1680 Tyr Asp Lys Ile Arg Ala Ala Gly Gly His Leu Cys Gln Gln Pro Lys 1685 1690 1695 Asp Ile Glu Cys Gln Ala Glu Ser Phe Pro Asn Trp Thr Leu Ala Gln 1700 1705 1710 Val Gly Gln Lys Val His Cys Asp Val His Phe Gly Leu Val Cys Arg 1715 1720 1725 Asn Trp Glu Gln Glu Gly Val Phe Lys Met Cys Tyr Asn Tyr Arg Ile 1730 1735 1740 Arg Val Leu Cys Cys Ser Asp Asp His Cys Arg Gly Arg Ala Thr Thr 1745 1750 1755 1760 Pro Pro Pro Thr Thr Glu Leu Glu Thr Ala Thr Thr Thr Thr Thr Gln 1765 1770 1775 Ala Leu Phe Ser Thr Pro Gln Pro Thr Ser Ser Pro Gly Leu Thr Arg 1780 1785 1790 Ala Pro Pro Ala Ser Thr Thr Ala Val Pro Thr Leu Ser Glu Gly Leu 1795 1800 1805 Thr Ser Pro Arg Tyr Thr Ser Thr Leu Gly Thr Ala Thr Thr Gly Gly 1810 1815 1820 Pro Thr Thr Pro Ala Gly Ser Thr Glu Pro Thr Val Pro Gly Val Ala 1825 1830 1835 1840 Thr Ser Thr Leu Pro Thr Arg Ser Ala Leu Pro Gly Thr Thr Gly Ser 1845 1850 1855 Leu Gly Thr Trp Arg Pro Ser Gln Pro Pro Thr Leu Ala Pro Thr Thr 1860 1865 1870 Met Ala Thr Ser Arg Ala Arg Pro Thr Gly Thr Ala Ser Thr Ala Ser 1875 1880 1885 Lys Glu Pro Leu Thr Thr Ser Leu Ala Pro Thr Leu Thr Ser Glu Leu 1890 1895 1900 Ser Thr Ser Gln Ala Glu Thr Ser Thr Pro Arg Thr Glu Thr Thr Met 1905 1910 1915 1920 Ser Pro Leu Thr Asn Thr Thr Thr Ser Gln Gly Thr Thr Arg Cys Gln 1925 1930 1935 Pro Lys Cys Glu Trp Thr Glu Trp Phe Asp Val Asp Phe Pro Thr Ser 1940 1945 1950 Gly Val Ala Gly Gly Asp Met Glu Thr Phe Glu Asn Ile Arg Ala Ala 1955 1960 1965 Gly Gly Lys Met Cys Trp Ala Pro Lys Ser Ile Glu Cys Arg Ala Glu 1970 1975 1980 Asn Tyr Pro Glu Val Ser Ile Asp Gln Val Gly Gln Val Leu Thr Cys 1985 1990 1995 2000 Ser Leu Glu Thr Gly Leu Thr Cys Lys Asn Glu Asp Gln Thr Gly Arg 2005 2010 2015 Phe Asn Met Cys Phe Asn Tyr Asn Val Arg Val Leu Cys Cys Asp Asp 2020 2025 2030 Tyr Ser His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro 2035 2040 2045 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Pro Thr Thr Thr 2050 2055 2060 Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Thr Ser Thr 2065 2070 2075 2080 Leu Arg Thr Ala Pro Pro Pro Lys Val Leu Thr Thr Thr Ala Thr Thr 2085 2090 2095 Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr 2100 2105 2110 Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala 2115 2120 2125 Thr Ser Val Thr Pro Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr 2130 2135 2140 Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr 2145 2150 2155 2160 Pro Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Ala 2165 2170 2175 Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser 2180 2185 2190 Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr 2195 2200 2205 Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro 2210 2215 2220 Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr 2225 2230 2235 2240 Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Thr Val Leu 2245 2250 2255 Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser 2260 2265 2270 Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala 2275 2280 2285 Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro 2290 2295 2300 Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro 2305 2310 2315 2320 Ala Ala Thr Ser Asn Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr 2325 2330 2335 His Thr Pro Pro Val Pro Asn Thr Met Ala Thr Thr His Gly Arg Ser 2340 2345 2350 Leu Pro Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala 2355 2360 2365 Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Val 2370 2375 2380 Thr Ser His Thr Leu Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr 2385 2390 2395 2400 Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro 2405 2410 2415 Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg 2420 2425 2430 Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu 2435 2440 2445 Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly 2450 2455 2460 Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro 2465 2470 2475 2480 Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg 2485 2490 2495 Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg 2500 2505 2510 Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val 2515 2520 2525 Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val 2530 2535 2540 Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys 2545 2550 2555 2560 Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met 2565 2570 2575 Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr 2580 2585 2590 Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser 2595 2600 2605 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr 2610 2615 2620 Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala 2625 2630 2635 2640 Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val 2645 2650 2655 Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala 2660 2665 2670 Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe 2675 2680 2685 Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser 2690 2695 2700 Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser 2705 2710 2715 2720 Thr Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr 2725 2730 2735 Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly 2740 2745 2750 Thr Ala His Thr Thr Lys Val Leu Thr Thr Thr Thr Thr Gly Phe Thr 2755 2760 2765 Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Leu Pro Val Trp 2770 2775 2780 Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro 2785 2790 2795 2800 Ser Ser Ile Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr 2805 2810 2815 Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr 2820 2825 2830 Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile 2835 2840 2845 Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr 2850 2855 2860 Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr 2865 2870 2875 2880 Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro 2885 2890 2895 Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro 2900 2905 2910 Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly 2915 2920 2925 Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His 2930 2935 2940 Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu 2945 2950 2955 2960 Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro 2965 2970 2975 Gly Thr Thr Thr Pro Gly His Thr Arg Ala Thr Ser Arg Thr Thr Ala 2980 2985 2990 Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser 2995 3000 3005 Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro 3010 3015 3020 Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly 3025 3030 3035 3040 Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly 3045 3050 3055 Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala 3060 3065 3070 Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser 3075 3080 3085 Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe 3090 3095 3100 Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly 3105 3110 3115 3120 His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser 3125 3130 3135 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Gln Thr Thr Ala Ala Thr 3140 3145 3150 Thr Thr Ala Thr Thr Gly Ser Thr Ala Ile Pro Ser Ser Thr Pro Gly 3155 3160 3165 Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr 3170 3175 3180 Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr 3185 3190 3195 3200 Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser 3205 3210 3215 Phe Thr Pro Ile Pro Ser Phe Thr Leu Gly Thr Thr Gly Thr Leu Pro 3220 3225 3230 Glu Gln Thr Thr Thr Pro Met Ala Thr Met Ser Thr Ile His Pro Ser 3235 3240 3245 Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys Ala 3250 3255 3260 Thr Thr Thr Arg Ala Thr Ser Ser Met Ser Thr Pro Ser Ser Thr Pro 3265 3270 3275 3280 Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr Thr 3285 3290 3295 Ala Ala Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr 3300 3305 3310 Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr 3315 3320 3325 Gly Ser Thr Ala Thr Ala Ser Ser Thr Arg Ala Thr Ala Gly Thr Leu 3330 3335 3340 Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr Val Ile Ser Ser Arg 3345 3350 3355 3360 Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu 3365 3370 3375 Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr Ala Ile Pro 3380 3385 3390 Ser Ser Ser Leu Gly Thr Ala Trp Thr Arg Leu Ser Gln Thr Thr Thr 3395 3400 3405 Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr 3410 3415 3420 Val His Thr Ser Thr Val Leu Thr Thr Thr Thr Thr Thr Thr Arg Ala 3425 3430 3435 3440 Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr 3445 3450 3455 Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser 3460 3465 3470 Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr 3475 3480 3485 Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro 3490 3495 3500 Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr Thr Val 3505 3510 3515 3520 Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly 3525 3530 3535 Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly 3540 3545 3550 Arg Ser Leu Pro Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr 3555 3560 3565 Ser Ala Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser 3570 3575 3580 Thr Val Thr Ser His Thr Pro Ala Ala Thr Thr Ser Thr Thr Gln His 3585 3590 3595 3600 Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu 3605 3610 3615 Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Arg Gly Thr 3620 3625 3630 Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr 3635 3640 3645 Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr 3650 3655 3660 Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser 3665 3670 3675 3680 Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn 3685 3690 3695 Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu 3700 3705 3710 Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln 3715 3720 3725 Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu 3730 3735 3740 Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe 3745 3750 3755 3760 Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr 3765 3770 3775 Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Leu 3780 3785 3790 Thr Thr Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro 3795 3800 3805 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr 3810 3815 3820 Ala Thr Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr 3825 3830 3835 3840 Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro 3845 3850 3855 Thr Val Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala 3860 3865 3870 Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr 3875 3880 3885 Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg 3890 3895 3900 Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro 3905 3910 3915 3920 Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Thr Thr 3925 3930 3935 Ala Thr Thr Thr Arg Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr 3940 3945 3950 Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly 3955 3960 3965 Phe Thr Val Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Pro Pro 3970 3975 3980 Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val 3985 3990 3995 4000 Thr Pro Ser Ser Val Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr 4005 4010 4015 Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser 4020 4025 4030 Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Ile Thr Thr Ala Thr 4035 4040 4045 Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly 4050 4055 4060 Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala 4065 4070 4075 4080 Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His 4085 4090 4095 Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu 4100 4105 4110 Ser Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr 4115 4120 4125 Ser Gly Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr 4130 4135 4140 Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro 4145 4150 4155 4160 Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro 4165 4170 4175 Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr 4180 4185 4190 Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro 4195 4200 4205 Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Thr Gly Cys 4210 4215 4220 Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met 4225 4230 4235 4240 Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala 4245 4250 4255 Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala 4260 4265 4270 Gln Ala Gln Pro Gly Val Pro Leu Gly Glu Leu Gly Gln Val Val Glu 4275 4280 4285 Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly 4290 4295 4300 Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn 4305 4310 4315 4320 Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met Pro 4325 4330 4335 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr 4340 4345 4350 Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr 4355 4360 4365 Pro Gly Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Pro Ala Thr Thr 4370 4375 4380 Pro Thr Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr 4385 4390 4395 4400 Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala 4405 4410 4415 Thr Ser Val Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr 4420 4425 4430 Leu Pro Glu Gln Thr Thr Thr Pro Val Ala Thr Met Ser Thr Ile His 4435 4440 4445 Pro Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr 4450 4455 4460 Lys Ala Thr Thr Thr Arg Ala Thr Ser Ser Thr Ser Thr Pro Ser Ser 4465 4470 4475 4480 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr 4485 4490 4495 Thr Thr Ala Ala Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly 4500 4505 4510 Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala 4515 4520 4525 Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp 4530 4535 4540 Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr Gly 4545 4550 4555 4560 Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr Pro His 4565 4570 4575 Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr 4580 4585 4590 Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser 4595 4600 4605 Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser 4610 4615 4620 Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr 4625 4630 4635 4640 Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His 4645 4650 4655 Thr Ser Thr Val Leu Thr Ala Thr Ala Thr Thr Thr Gly Ala Thr Gly 4660 4665 4670 Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys 4675 4680 4685 Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser 4690 4695 4700 Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr 4705 4710 4715 4720 Pro Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser 4725 4730 4735 Ser Ile Pro Gly Thr Thr His Thr Ala Arg Val Leu Thr Thr Thr Thr 4740 4745 4750 Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln 4755 4760 4765 Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr 4770 4775 4780 Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro 4785 4790 4795 4800 Ile Thr Pro Val Leu Thr Ser Thr Ala Thr Thr Pro Ala Ala Thr Ser 4805 4810 4815 Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro 4820 4825 4830 Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro 4835 4840 4845 Ile Pro Ser Ser Thr Leu Trp Thr Thr Trp Thr Val Pro Ala Gln Thr 4850 4855 4860 Thr Thr Pro Met Ser Thr Met Ser Thr Ile His Thr Ser Ser Thr Pro 4865 4870 4875 4880 Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Met Thr 4885 4890 4895 Arg Ala Thr Asn Ser Thr Ala Thr Pro Ser Ser Thr Leu Gly Thr Thr 4900 4905 4910 Arg Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ala Thr 4915 4920 4925 Gly Ser Thr Ala Thr Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu 4930 4935 4940 Thr Glu Pro Ser Thr Ile Ala Thr Val Met Val Pro Thr Gly Ser Thr 4945 4950 4955 4960 Ala Thr Ala Ser Ser Thr Leu Gly Thr Ala His Thr Pro Lys Val Val 4965 4970 4975 Thr Thr Met Ala Thr Met Pro Thr Ala Thr Ala Ser Thr Val Pro Ser 4980 4985 4990 Ser Ser Thr Val Gly Thr Thr Arg Thr Pro Ala Val Leu Pro Ser Ser 4995 5000 5005 Leu Pro Thr Phe Ser Val Ser Thr Val Ser Ser Ser Val Leu Thr Thr 5010 5015 5020 Leu Arg Pro Thr Gly Phe Pro Ser Ser His Phe Ser Thr Pro Cys Phe 5025 5030 5035 5040 Cys Arg Ala Phe Gly Gln Phe Phe Ser Pro Gly Glu Val Ile Tyr Asn 5045 5050 5055 Lys Thr Asp Arg Ala Gly Cys His Phe Tyr Ala Val Cys Asn Gln His 5060 5065 5070 Cys Asp Ile Asp Arg Phe Gln Gly Ala Cys Pro Thr Ser Pro Pro Pro 5075 5080 5085 Val Ser Ser Ala Pro Leu Ser Ser Pro Ser Pro Ala Pro Gly Cys Asp 5090 5095 5100 Asn Ala Ile Pro Leu Arg Gln Val Asn Glu Thr Trp Thr Leu Glu Asn 5105 5110 5115 5120 Cys Thr Val Ala Arg Cys Val Gly Asp Asn Arg Val Val Leu Leu Asp 5125 5130 5135 Pro Lys Pro Val Ala Asn Val Thr Cys Val Asn Lys His Leu Pro Ile 5140 5145 5150 Lys Val Ser Asp Pro Ser Gln Pro Cys Asp Phe His Tyr Glu Cys Glu 5155 5160 5165 Cys Ile Cys Ser Met Trp Gly Gly Ser His Tyr Ser Thr Phe Asp Gly 5170 5175 5180 Thr Ser Tyr Thr Phe Arg Gly Asn Cys Thr Tyr Val Leu Met Arg Glu 5185 5190 5195 5200 Ile His Ala Arg Phe Gly Asn Leu Ser Leu Tyr Leu Asp Asn His Tyr 5205 5210 5215 Cys Thr Ala Ser Ala Thr Ala Ala Ala Ala Arg Cys Pro Arg Ala Leu 5220 5225 5230 Ser Ile His Tyr Lys Ser Met Asp Ile Val Leu Thr Val Thr Met Val 5235 5240 5245 His Gly Lys Glu Glu Gly Leu Ile Leu Phe Asp Gln Ile Pro Val Ser 5250 5255 5260 Ser Gly Phe Ser Lys Asn Gly Val Leu Val Ser Val Leu Gly Thr Thr 5265 5270 5275 5280 Thr Met Arg Val Asp Ile Pro Ala Leu Gly Val Ser Val Thr Phe Asn 5285 5290 5295 Gly Gln Val Phe Gln Ala Arg Leu Pro Tyr Ser Leu Phe His Asn Asn 5300 5305 5310 Thr Glu Gly Gln Cys Gly Thr Cys Thr Asn Asn Gln Arg Asp Asp Cys 5315 5320 5325 Leu Gln Arg Asp Gly Thr Thr Ala Ala Ser Cys Lys Asp Met Ala Lys 5330 5335 5340 Thr Trp Leu Val Pro Asp Ser Arg Lys Asp Gly Cys Trp Ala Pro Thr 5345 5350 5355 5360 Gly Thr Pro Pro Thr Ala Ser Pro Ala Ala Pro Val Ser Ser Thr Pro 5365 5370 5375 Thr Pro Thr Pro Cys Pro Pro Gln Pro Leu Cys Asp Leu Met Leu Ser 5380 5385 5390 Gln Val Phe Ala Glu Cys His Asn Leu Val Pro Pro Gly Pro Phe Phe 5395 5400 5405 Asn Ala Cys Ile Ser Asp His Cys Arg Gly Arg Leu Glu Val Pro Cys 5410 5415 5420 Gln Ser Leu Glu Ala Tyr Ala Glu Leu Cys Arg Ala Arg Gly Val Cys 5425 5430 5435 5440 Ser Asp Trp Arg Gly Ala Thr Gly Gly Leu Cys Asp Leu Thr Cys Pro 5445 5450 5455 Pro Thr Lys Val Tyr Lys Pro Cys Gly Pro Ile Gln Pro Ala Thr Cys 5460 5465 5470 Asn Ser Arg Asn Gln Ser Pro Gln Leu Glu Gly Met Ala Glu Gly Cys 5475 5480 5485 Phe Cys Pro Glu Asp Gln Ile Leu Phe Asn Ala His Met Gly Ile Cys 5490 5495 5500 Val Gln Ala Cys Pro Cys Val Gly Pro Asp Gly Phe Pro Lys Phe Pro 5505 5510 5515 5520 Gly Glu Arg Trp Val Ser Asn Cys Gln Ser Cys Val Cys Asp Glu Gly 5525 5530 5535 Ser Val Ser Val Gln Cys Lys Pro Leu Pro Cys Asp Ala Gln Gly Gln 5540 5545 5550 Pro Pro Pro Cys Asn Arg Pro Gly Phe Val Thr Val Thr Arg Pro Arg 5555 5560 5565 Ala Glu Asn Pro Cys Cys Pro Glu Thr Val Cys Val Cys Asn Thr Thr 5570 5575 5580 Thr Cys Pro Gln Ser Leu Pro Val Cys Pro Pro Gly Gln Glu Ser Ile 5585 5590 5595 5600 Cys Thr Gln Glu Glu Gly Asp Cys Cys Pro Thr Phe Arg Cys Arg Pro 5605 5610 5615 Gln Leu Cys Ser Tyr Asn Gly Thr Phe Tyr Gly Val Gly Ala Thr Phe 5620 5625 5630 Pro Gly Ala Leu Pro Cys His Met Cys Thr Cys Leu Ser Gly Asp Thr 5635 5640 5645 Gln Asp Pro Thr Val Gln Cys Gln Glu Asp Ala Cys Asn Asn Thr Thr 5650 5655 5660 Cys Pro Gln Gly Phe Glu Tyr Lys Arg Val Ala Gly Gln Cys Cys Gly 5665 5670 5675 5680 Glu Cys Val Gln Thr Ala Cys Leu Thr Pro Asp Gly Gln Pro Val Gln 5685 5690 5695 Leu Asn Glu Thr Trp Val Asn Ser His Val Asp Asn Cys Thr Val Tyr 5700 5705 5710 Leu Cys Glu Ala Glu Gly Gly Val His Leu Leu Thr Pro Gln Pro Ala 5715 5720 5725 Ser Cys Pro Asp Val Ser Ser Cys Arg Gly Ser Leu Arg Lys Thr Gly 5730 5735 5740 Cys Cys Tyr Ser Cys Glu Glu Asp Ser Cys Gln Val Arg Ile Asn Thr 5745 5750 5755 5760 Thr Ile Leu Trp His Gln Gly Cys Glu Thr Glu Val Asn Ile Thr Phe 5765 5770 5775 Cys Glu Gly Ser Cys Pro Gly Ala Ser Lys Tyr Ser Ala Glu Ala Gln 5780 5785 5790 Ala Met Gln His Gln Cys Thr Cys Cys Gln Glu Arg Arg Val His Glu 5795 5800 5805 Glu Thr Val Pro Leu His Cys Pro Asn Gly Ser Ala Ile Leu His Thr 5810 5815 5820 Tyr Thr His Val Asp Glu Cys Gly Cys Thr Pro Phe Cys Val Pro Ala 5825 5830 5835 5840 Pro Met Ala Pro Pro His Thr Arg Gly Phe Pro Ala Gln Glu Ala Thr 5845 5850 5855 Ala Val <210> SEQ ID NO 83 <211> LENGTH: 619 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 83 Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 1 5 10 15 Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 20 25 30 Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 35 40 45 Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 50 55 60 Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 65 70 75 80 Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 85 90 95 Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 100 105 110 Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile Phe Ser Ser Pro 115 120 125 Glu Asp Asp Met Val Val Ala Pro Val Thr His Val Ser Val Thr Leu 130 135 140 Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val Gln Glu Lys Tyr 145 150 155 160 Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro Lys Arg Lys Lys 165 170 175 Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro Ala Thr Thr Pro 180 185 190 Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys Gly Asn Thr Ile 195 200 205 Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Lys Ala Thr Cys 210 215 220 Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys Leu 225 230 235 240 Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys His Lys Asn Lys 245 250 255 Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr Tyr 260 265 270 Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr Gln 275 280 285 Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn Asp Glu Asp Pro 290 295 300 Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser Ser Ser Ala Thr 305 310 315 320 Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser Ser Ser Pro Gly 325 330 335 Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly Asn Ser Lys Ala 340 345 350 Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro Ser Glu Val Leu 355 360 365 Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr Gln Leu Phe Arg 370 375 380 Thr Val His Val Val Gln Pro Val Gln Ala Val Pro Glu Gly Glu Ala 385 390 395 400 Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn Ser Ser Val Gln 405 410 415 Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro Val Val Val Ser 420 425 430 Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln Thr Val Pro Leu 435 440 445 Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly Thr Gly Ser Gln 450 455 460 Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro Met Thr Val Leu 465 470 475 480 Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly Ser Pro Pro Ser 485 490 495 Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu Thr Ser Asn Val 500 505 510 Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser Ser Pro Ser Phe 515 520 525 Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg Ser Ser Gln Leu 530 535 540 Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val Ile Lys Thr Gln 545 550 555 560 Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys Glu Ser Glu Asp 565 570 575 His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln Pro Gln Pro Tyr 580 585 590 Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser Gln Val Ala Met 595 600 605 Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe 610 615 <210> SEQ ID NO 84 <211> LENGTH: 753 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 84 Met Gly Glu His Ser Pro Asp Asn Asn Ile Ile Tyr Phe Glu Ala Glu 1 5 10 15 Glu Asp Glu Leu Thr Pro Asp Asp Lys Met Leu Arg Phe Val Asp Lys 20 25 30 Asn Gly Leu Val Pro Ser Ser Ser Gly Thr Val Tyr Asp Arg Thr Thr 35 40 45 Val Leu Ile Glu Gln Asp Pro Gly Thr Leu Glu Asp Glu Asp Asp Asp 50 55 60 Gly Gln Cys Gly Glu His Leu Pro Phe Leu Val Gly Gly Glu Glu Gly 65 70 75 80 Phe His Leu Ile Asp His Glu Ala Met Ser Gln Gly Tyr Val Gln His 85 90 95 Ile Ile Ser Pro Asp Gln Ile His Leu Thr Ile Asn Pro Gly Ser Thr 100 105 110 Pro Met Pro Arg Asn Ile Glu Gly Ala Thr Leu Thr Leu Gln Ser Glu 115 120 125 Cys Pro Glu Thr Lys Arg Lys Glu Val Lys Arg Tyr Gln Cys Thr Phe 130 135 140 Glu Gly Cys Pro Arg Thr Tyr Ser Thr Ala Gly Asn Leu Arg Thr His 145 150 155 160 Gln Lys Thr His Arg Gly Glu Tyr Thr Phe Val Cys Asn Gln Glu Gly 165 170 175 Cys Gly Lys Ala Phe Leu Thr Ser His Ser Leu Arg Ile His Val Arg 180 185 190 Val His Thr Lys Glu Lys Pro Phe Glu Cys Asp Val Gln Gly Cys Glu 195 200 205 Lys Ala Phe Asn Thr Leu Tyr Arg Leu Lys Ala His Gln Arg Leu His 210 215 220 Thr Gly Lys Thr Phe Asn Cys Glu Ser Glu Gly Cys Ser Lys Tyr Phe 225 230 235 240 Thr Thr Leu Ser Asp Leu Arg Lys His Ile Arg Thr His Thr Gly Glu 245 250 255 Lys Pro Phe Arg Cys Asp His Asp Gly Cys Gly Lys Ala Phe Ala Ala 260 265 270 Ser His His Leu Lys Thr His Val Arg Thr His Thr Gly Glu Arg Pro 275 280 285 Phe Phe Cys Pro Ser Asn Gly Cys Glu Lys Thr Phe Ser Thr Gln Tyr 290 295 300 Ser Leu Lys Ser His Met Lys Gly His Asp Asn Lys Gly His Ser Tyr 305 310 315 320 Asn Ala Leu Pro Gln His Asn Gly Ser Glu Asp Thr Asn His Ser Leu 325 330 335 Cys Leu Ser Asp Leu Ser Leu Leu Ser Thr Asp Ser Glu Leu Arg Glu 340 345 350 Asn Ser Ser Thr Thr Gln Gly Gln Asp Leu Ser Thr Ile Ser Pro Ala 355 360 365 Ile Ile Phe Glu Ser Met Phe Gln Asn Ser Asp Asp Thr Ala Ile Gln 370 375 380 Glu Asp Pro Gln Gln Thr Ala Ser Leu Thr Glu Ser Phe Asn Gly Asp 385 390 395 400 Ala Glu Ser Val Ser Asp Val Pro Pro Ser Thr Gly Asn Ser Ala Ser 405 410 415 Leu Ser Leu Pro Leu Val Leu Gln Pro Gly Leu Ser Glu Pro Pro Gln 420 425 430 Pro Leu Leu Pro Ala Ser Ala Pro Ser Ala Pro Pro Pro Ala Pro Ser 435 440 445 Leu Gly Pro Gly Ser Gln Gln Ala Ala Phe Gly Asn Pro Pro Ala Leu 450 455 460 Leu Gln Pro Pro Glu Val Pro Val Pro His Ser Thr Gln Phe Ala Ala 465 470 475 480 Asn His Gln Glu Phe Leu Pro His Pro Gln Ala Pro Gln Pro Ile Val 485 490 495 Pro Gly Leu Ser Val Val Ala Gly Ala Ser Ala Ser Ala Ala Ala Val 500 505 510 Ala Ser Ala Val Ala Ala Pro Ala Pro Pro Gln Ser Thr Thr Glu Pro 515 520 525 Leu Pro Ala Met Val Gln Thr Leu Pro Leu Gly Ala Asn Ser Val Leu 530 535 540 Thr Asn Asn Pro Thr Ile Thr Ile Thr Pro Thr Pro Asn Thr Ala Ile 545 550 555 560 Leu Gln Ser Ser Leu Val Met Gly Glu Gln Asn Leu Gln Trp Ile Leu 565 570 575 Asn Gly Ala Thr Ser Ser Pro Gln Asn Gln Glu Gln Ile Gln Gln Ala 580 585 590 Ser Lys Val Glu Lys Val Phe Phe Thr Thr Ala Val Pro Val Ala Ser 595 600 605 Ser Pro Gly Ser Ser Val Gln Gln Ile Gly Leu Ser Val Pro Val Ile 610 615 620 Ile Ile Lys Gln Glu Glu Ala Cys Gln Cys Gln Cys Ala Cys Arg Asp 625 630 635 640 Ser Ala Lys Glu Arg Ala Ser Ser Arg Arg Lys Gly Cys Ser Ser Pro 645 650 655 Pro Pro Pro Glu Pro Ser Pro Gln Ala Pro Asp Gly Pro Ser Leu Gln 660 665 670 Leu Pro Ala Gln Thr Phe Ser Ser Ala Pro Val Pro Gly Ser Ser Ser 675 680 685 Ser Thr Leu Pro Ser Ser Cys Glu Gln Ser Arg Gln Ala Glu Thr Pro 690 695 700 Ser Asp Pro Gln Thr Glu Thr Leu Ser Ala Met Asp Val Ser Glu Phe 705 710 715 720 Leu Ser Leu Gln Ser Leu Asp Thr Pro Ser Asn Leu Ile Pro Ile Glu 725 730 735 Ala Leu Leu Gln Gly Glu Glu Glu Met Gly Leu Thr Ser Ser Phe Ser 740 745 750 Lys <210> SEQ ID NO 85 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 85 Met Leu Cys Ala His Phe Ser Asp Gln Gly Pro Ala His Leu Thr Thr 1 5 10 15 Ser Lys Ser Ala Phe Leu Ser Asn Lys Lys Thr Ser Thr Leu Lys His 20 25 30 Leu Leu Gly Glu Thr Arg Ser Asp Gly Ser Ala Cys Asn Ser Gly Ile 35 40 45 Ser Gly Gly Arg Gly Arg Lys Ile Pro 50 55 <210> SEQ ID NO 86 <211> LENGTH: 726 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 1 5 10 15 Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 20 25 30 Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 35 40 45 Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 50 55 60 Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 65 70 75 80 Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 85 90 95 Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 100 105 110 His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 115 120 125 Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 130 135 140 Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 145 150 155 160 Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 165 170 175 Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 180 185 190 Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 195 200 205 Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 210 215 220 Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 225 230 235 240 Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 245 250 255 Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 260 265 270 Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 275 280 285 Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 290 295 300 Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 305 310 315 320 Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 325 330 335 Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 340 345 350 Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 355 360 365 Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 370 375 380 Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 385 390 395 400 Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 405 410 415 Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 420 425 430 Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 435 440 445 Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 450 455 460 Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 465 470 475 480 Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 485 490 495 Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 500 505 510 His Pro Ser Asn His His His His His Asn His His Ser His Lys His 515 520 525 Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 530 535 540 Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 545 550 555 560 Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 565 570 575 Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 580 585 590 Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 595 600 605 Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 610 615 620 Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 625 630 635 640 Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 645 650 655 Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 660 665 670 Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 675 680 685 Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 690 695 700 Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 705 710 715 720 Leu Pro Pro Leu Pro Lys 725 <210> SEQ ID NO 87 <211> LENGTH: 591 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 87 Met Tyr Leu Lys Asp Tyr Glu Arg Lys Val Ile Leu Glu Lys Ala Gly 1 5 10 15 Lys Tyr Val Asp Glu Glu Asn Ser Asp Gly Glu Thr Ser Asn His Arg 20 25 30 Leu Gln Glu Thr Ser Ser Gln Ser Tyr Val Glu Glu Gln Lys Gln Leu 35 40 45 Lys Glu Ser Phe Arg Ala Phe Val Glu Asp Ser Glu Asp Glu Asp Gly 50 55 60 Ala Gly Glu Gly Gly Ser Ser Leu Leu Gln Lys Arg Ala Lys Thr Arg 65 70 75 80 Gln Glu Lys Ala Gln Glu Glu Ala Asp Tyr Ile Glu Trp Leu Lys Gly 85 90 95 Gln Lys Glu Ile Arg Asn Pro Asp Ser Leu Lys Glu Leu Thr His Leu 100 105 110 Lys Glu Tyr Trp Asn Asp Pro Glu Leu Asp Glu Gly Glu Arg Phe Leu 115 120 125 Arg Asp Tyr Ile Leu Asn Lys Arg Tyr Glu Glu Glu Glu Glu Glu Glu 130 135 140 Glu Asp Glu Glu Glu Met Glu Glu Glu Lys Gly Val His Gly Pro Pro 145 150 155 160 Val Gln Leu Ala Val Asp Asp Ser Ser Asp Glu Gly Glu Leu Phe Leu 165 170 175 Lys Lys Gln Glu Asp Phe Glu Gln Lys Tyr Asn Phe Arg Phe Glu Glu 180 185 190 Pro Asp Ser Ala Ser Val Lys Thr Tyr Pro Arg Ser Ile Ala Ser Ser 195 200 205 Val Arg Arg Lys Asp Glu Arg Arg Lys Glu Lys Arg Glu Glu Thr Arg 210 215 220 Glu Arg Lys Lys Arg Glu Lys Ala Lys Lys Gln Glu Glu Leu Lys Gln 225 230 235 240 Leu Lys Asn Leu Lys Arg Lys Glu Ile Leu Ala Lys Leu Glu Lys Leu 245 250 255 Arg Lys Val Thr Gly Asn Glu Met Leu Gly Leu Glu Glu Gly Asp Leu 260 265 270 Glu Asp Asp Phe Asp Pro Ala Gln His Asp Gln Leu Met Gln Lys Cys 275 280 285 Phe Gly Asp Glu Tyr Tyr Gly Ala Val Glu Glu Glu Lys Pro Gln Phe 290 295 300 Glu Glu Glu Glu Gly Leu Glu Asp Asp Trp Asn Trp Asp Thr Trp Asp 305 310 315 320 Gly Pro Glu Gln Glu Gly Asp Trp Ser Gln Gln Glu Leu His Cys Glu 325 330 335 Asp Pro Asn Phe Asn Met Asp Ala Asp Tyr Asp Pro Ser Gln Pro Arg 340 345 350 Lys Lys Lys Arg Glu Ala Pro Leu Thr Gly Lys Lys Lys Arg Lys Ser 355 360 365 Pro Phe Ala Ala Ala Val Gly Gln Glu Lys Pro Val Phe Glu Pro Gly 370 375 380 Asp Lys Thr Phe Glu Glu Tyr Leu Asp Glu Tyr Tyr Arg Leu Asp Tyr 385 390 395 400 Glu Asp Ile Ile Asp Asp Leu Pro Cys Arg Phe Lys Tyr Arg Thr Val 405 410 415 Val Pro Cys Asp Phe Gly Leu Ser Thr Glu Glu Ile Leu Ala Ala Asp 420 425 430 Asp Lys Glu Leu Asn Arg Trp Cys Ser Leu Lys Lys Thr Cys Met Tyr 435 440 445 Arg Ser Glu Gln Glu Glu Leu Arg Asp Lys Arg Ala Tyr Ser Gln Lys 450 455 460 Ala Gln Asn Ser Trp Lys Lys Arg Gln Val Phe Lys Ser Leu Cys Arg 465 470 475 480 Glu Glu Ala Glu Thr Pro Ala Glu Ala Thr Gly Lys Pro Gln Arg Asp 485 490 495 Glu Ala Gly Pro Gln Arg Gln Leu Pro Ala Leu Asp Gly Ser Leu Met 500 505 510 Gly Pro Glu Ser Pro Pro Ala Gln Glu Glu Glu Ala Pro Val Ser Pro 515 520 525 His Lys Lys Pro Ala Pro Gln Lys Arg Arg Arg Ala Lys Lys Ala Arg 530 535 540 Leu Leu Gly Pro Thr Val Met Leu Gly Gly Cys Glu Phe Ser Arg Gln 545 550 555 560 Arg Leu Gln Ala Phe Gly Leu Asn Pro Lys Arg Leu His Phe Arg Gln 565 570 575 Leu Gly Arg Gln Arg Arg Lys Gln Gln Gly Pro Lys Asn Ser Ser 580 585 590 <210> SEQ ID NO 88 <211> LENGTH: 709 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Met Gly His Arg Thr Ala Met Pro Glu Pro Arg Gly Ser Ser Gln Leu 1 5 10 15 Arg Val Asn Ala Ala Phe Ala Ala Arg Tyr Asn Arg Tyr Arg Glu Arg 20 25 30 Glu Glu Leu Gln Arg Leu Lys Asp Arg Tyr Gly Asp Arg Asp Ser Ser 35 40 45 Ser Asp Ser Ser Ser Glu Ser Asp Ser Ser Asp Glu Arg Val Glu Phe 50 55 60 Asp Pro Gln Gln Glu Arg Asp Phe Tyr Lys Thr Leu Ser Leu Leu Lys 65 70 75 80 Lys Lys Asp Pro Arg Ile Tyr Gln Lys Asp Ala Thr Phe Tyr Asn Arg 85 90 95 Thr Ala Ser Ser Ser Asp Ser Glu Glu Asp Pro Glu Ala Leu Glu Lys 100 105 110 Gln Lys Lys Val Arg Pro Met Tyr Leu Lys Asp Tyr Glu Arg Lys Val 115 120 125 Ile Leu Glu Lys Ala Gly Lys Tyr Val Asp Glu Glu Asn Ser Asp Gly 130 135 140 Glu Thr Ser Asn His Arg Leu Gln Glu Thr Ser Ser Gln Ser Tyr Val 145 150 155 160 Glu Glu Gln Lys Gln Leu Lys Glu Ser Phe Arg Ala Phe Val Glu Asp 165 170 175 Ser Glu Asp Glu Asp Gly Ala Gly Glu Gly Gly Ser Ser Leu Leu Gln 180 185 190 Lys Arg Ala Lys Thr Arg Gln Glu Lys Ala Gln Glu Glu Ala Asp Tyr 195 200 205 Ile Glu Trp Leu Lys Gly Gln Lys Glu Ile Arg Asn Pro Asp Ser Leu 210 215 220 Lys Glu Leu Thr His Leu Lys Glu Tyr Trp Asn Asp Pro Glu Leu Asp 225 230 235 240 Glu Gly Glu Arg Phe Leu Arg Asp Tyr Ile Leu Asn Lys Arg Tyr Glu 245 250 255 Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Met Glu Glu Glu Lys 260 265 270 Gly Val His Gly Pro Pro Val Gln Leu Ala Val Asp Asp Ser Ser Asp 275 280 285 Glu Gly Glu Leu Phe Leu Lys Lys Gln Glu Asp Phe Glu Gln Lys Tyr 290 295 300 Asn Phe Arg Phe Glu Glu Pro Asp Ser Ala Ser Val Lys Thr Tyr Pro 305 310 315 320 Arg Ser Ile Ala Ser Ser Val Arg Arg Lys Asp Glu Arg Arg Lys Glu 325 330 335 Lys Arg Glu Glu Thr Arg Glu Arg Lys Lys Arg Glu Lys Ala Lys Lys 340 345 350 Gln Glu Glu Leu Lys Gln Leu Lys Asn Leu Lys Arg Lys Glu Ile Leu 355 360 365 Ala Lys Leu Glu Lys Leu Arg Lys Val Thr Gly Asn Glu Met Leu Gly 370 375 380 Leu Glu Glu Gly Asp Leu Glu Asp Asp Phe Asp Pro Ala Gln His Asp 385 390 395 400 Gln Leu Met Gln Lys Cys Phe Gly Asp Glu Tyr Tyr Gly Ala Val Glu 405 410 415 Glu Glu Lys Pro Gln Phe Glu Glu Glu Glu Gly Leu Glu Asp Asp Trp 420 425 430 Asn Trp Asp Thr Trp Asp Gly Pro Glu Gln Glu Gly Asp Trp Ser Gln 435 440 445 Gln Glu Leu His Cys Glu Asp Pro Asn Phe Asn Met Asp Ala Asp Tyr 450 455 460 Asp Pro Ser Gln Pro Arg Lys Lys Lys Arg Glu Ala Pro Leu Thr Gly 465 470 475 480 Lys Lys Lys Arg Lys Ser Pro Phe Ala Ala Ala Val Gly Gln Glu Lys 485 490 495 Pro Val Phe Glu Pro Gly Asp Lys Thr Phe Glu Glu Tyr Leu Asp Glu 500 505 510 Tyr Tyr Arg Leu Asp Tyr Glu Asp Ile Ile Asp Asp Leu Pro Cys Arg 515 520 525 Phe Lys Tyr Arg Thr Val Val Pro Cys Asp Phe Gly Leu Ser Thr Glu 530 535 540 Glu Ile Leu Ala Ala Asp Asp Lys Glu Leu Asn Arg Trp Cys Ser Leu 545 550 555 560 Lys Lys Thr Cys Met Tyr Arg Ser Glu Gln Glu Glu Leu Arg Asp Lys 565 570 575 Arg Ala Tyr Ser Gln Lys Ala Gln Asn Ser Trp Lys Lys Arg Gln Val 580 585 590 Phe Lys Ser Leu Cys Arg Glu Glu Ala Glu Thr Pro Ala Glu Ala Thr 595 600 605 Gly Lys Pro Gln Arg Asp Glu Ala Gly Pro Gln Arg Gln Leu Pro Ala 610 615 620 Leu Asp Gly Ser Leu Met Gly Pro Glu Ser Pro Pro Ala Gln Glu Glu 625 630 635 640 Glu Ala Pro Val Ser Pro His Lys Lys Pro Ala Pro Gln Lys Arg Arg 645 650 655 Arg Ala Lys Lys Ala Arg Leu Leu Gly Pro Thr Val Met Leu Gly Gly 660 665 670 Cys Glu Phe Ser Arg Gln Arg Leu Gln Ala Phe Gly Leu Asn Pro Lys 675 680 685 Arg Leu His Phe Arg Gln Leu Gly Arg Gln Arg Arg Lys Gln Gln Gly 690 695 700 Pro Lys Asn Ser Ser 705 <210> SEQ ID NO 89 <211> LENGTH: 1198 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 89 Met Ala Pro Val Tyr Glu Gly Met Ala Ser His Val Gln Val Phe Ser 1 5 10 15 Pro His Thr Leu Gln Ser Ser Ala Phe Cys Ser Val Lys Lys Leu Lys 20 25 30 Val Glu Pro Ser Ser Asn Trp Asp Met Thr Gly Tyr Gly Ser His Ser 35 40 45 Lys Val Tyr Ser Gln Ser Lys Asn Ile Pro Pro Ser Gln Pro Ala Ser 50 55 60 Thr Thr Val Ser Thr Ser Leu Pro Val Pro Asn Pro Ser Leu Pro Tyr 65 70 75 80 Glu Gln Thr Ile Val Phe Pro Gly Ser Thr Gly His Ile Val Val Thr 85 90 95 Ser Ala Ser Ser Thr Ser Val Thr Gly Gln Val Leu Gly Gly Pro His 100 105 110 Asn Leu Met Arg Arg Ser Thr Val Ser Leu Leu Asp Thr Tyr Gln Lys 115 120 125 Cys Gly Leu Lys Arg Lys Ser Glu Glu Ile Glu Asn Thr Ser Ser Val 130 135 140 Gln Ile Ile Glu Glu His Pro Pro Met Ile Gln Asn Asn Ala Ser Gly 145 150 155 160 Ala Thr Val Ala Thr Ala Thr Thr Ser Thr Ala Thr Ser Lys Asn Ser 165 170 175 Gly Ser Asn Ser Glu Gly Asp Tyr Gln Leu Val Gln His Glu Val Leu 180 185 190 Cys Ser Met Thr Asn Thr Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly 195 200 205 Thr Phe Gly Gln Val Val Lys Cys Trp Lys Arg Gly Thr Asn Glu Ile 210 215 220 Val Ala Ile Lys Ile Leu Lys Asn Arg Pro Ser Tyr Ala Arg Gln Gly 225 230 235 240 Gln Ile Glu Val Ser Ile Leu Ala Arg Leu Ser Thr Glu Ser Ala Asp 245 250 255 Asp Tyr Asn Phe Val Arg Ala Tyr Glu Cys Phe Gln His Lys Asn His 260 265 270 Thr Cys Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu 275 280 285 Lys Gln Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Val 290 295 300 Leu Gln Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu 305 310 315 320 Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Ser 325 330 335 Arg Gln Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His 340 345 350 Val Ser Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg 355 360 365 Ala Pro Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met 370 375 380 Trp Ser Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu 385 390 395 400 Tyr Pro Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr 405 410 415 Gln Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr 420 425 430 Arg Phe Phe Asn Arg Asp Thr Asp Ser Pro Tyr Pro Leu Trp Arg Leu 435 440 445 Lys Thr Pro Asp Asp His Glu Ala Glu Thr Gly Ile Lys Ser Lys Glu 450 455 460 Ala Arg Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn 465 470 475 480 Met Thr Thr Asp Leu Glu Gly Ser Asp Met Leu Val Glu Lys Ala Asp 485 490 495 Arg Arg Glu Phe Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala 500 505 510 Asp Lys Arg Ile Thr Pro Ile Glu Thr Leu Asn His Pro Phe Val Thr 515 520 525 Met Thr His Leu Leu Asp Phe Pro His Ser Thr His Val Lys Ser Cys 530 535 540 Phe Gln Asn Met Glu Ile Cys Lys Arg Arg Val Asn Met Tyr Asp Thr 545 550 555 560 Val Asn Gln Ser Lys Thr Pro Phe Ile Thr His Val Ala Pro Ser Thr 565 570 575 Ser Thr Asn Leu Thr Met Thr Phe Asn Asn Gln Leu Thr Thr Val His 580 585 590 Asn Gln Ala Pro Ser Ser Thr Ser Ala Thr Ile Ser Leu Ala Asn Pro 595 600 605 Glu Val Ser Ile Leu Asn Tyr Pro Ser Thr Leu Tyr Gln Pro Ser Ala 610 615 620 Ala Ser Met Ala Ala Val Ala Gln Arg Ser Met Pro Leu Gln Thr Gly 625 630 635 640 Thr Ala Gln Ile Cys Ala Arg Pro Asp Pro Phe Gln Gln Ala Leu Ile 645 650 655 Val Cys Pro Pro Gly Phe Gln Gly Leu Gln Ala Ser Pro Ser Lys His 660 665 670 Ala Gly Tyr Ser Val Arg Met Glu Asn Ala Val Pro Ile Val Thr Gln 675 680 685 Ala Pro Gly Ala Gln Pro Leu Gln Ile Gln Pro Gly Leu Leu Ala Gln 690 695 700 Gln Ala Trp Pro Ser Gly Thr Gln Gln Ile Leu Leu Pro Pro Ala Trp 705 710 715 720 Gln Gln Leu Thr Gly Val Ala Thr His Thr Ser Val Gln His Ala Thr 725 730 735 Val Ile Pro Glu Thr Met Ala Gly Thr Gln Gln Leu Ala Asp Trp Arg 740 745 750 Asn Thr His Ala His Gly Ser His Tyr Asn Pro Ile Met Gln Gln Pro 755 760 765 Ala Leu Leu Thr Gly His Val Thr Leu Pro Ala Ala Gln Pro Leu Asn 770 775 780 Val Gly Val Ala His Val Met Arg Gln Gln Pro Thr Ser Thr Thr Ser 785 790 795 800 Ser Arg Lys Ser Lys Gln His Gln Ser Ser Val Arg Asn Val Ser Thr 805 810 815 Cys Glu Val Ser Ser Ser Gln Ala Ile Ser Ser Pro Gln Arg Ser Lys 820 825 830 Arg Val Lys Glu Asn Thr Pro Pro Arg Cys Ala Met Val His Ser Ser 835 840 845 Pro Ala Cys Ser Thr Ser Val Thr Cys Gly Trp Gly Asp Val Ala Ser 850 855 860 Ser Thr Thr Arg Glu Arg Gln Arg Gln Thr Ile Val Ile Pro Asp Thr 865 870 875 880 Pro Ser Pro Thr Val Ser Val Ile Thr Ile Ser Ser Asp Thr Asp Glu 885 890 895 Glu Glu Glu Gln Lys His Ala Pro Thr Ser Thr Val Ser Lys Gln Arg 900 905 910 Lys Asn Val Ile Ser Cys Val Thr Val His Asp Ser Pro Tyr Ser Asp 915 920 925 Ser Ser Ser Asn Thr Ser Pro Tyr Ser Val Gln Gln Arg Ala Gly His 930 935 940 Asn Asn Ala Asn Ala Phe Asp Thr Lys Gly Ser Leu Glu Asn His Cys 945 950 955 960 Thr Gly Asn Pro Arg Thr Ile Ile Val Pro Pro Leu Lys Thr Gln Ala 965 970 975 Ser Glu Val Leu Val Glu Cys Asp Ser Leu Val Pro Val Asn Thr Ser 980 985 990 His His Ser Ser Ser Tyr Lys Ser Lys Ser Ser Ser Asn Val Thr Ser 995 1000 1005 Thr Ser Gly His Ser Ser Gly Ser Ser Ser Gly Ala Ile Thr Tyr Arg 1010 1015 1020 Gln Gln Arg Pro Gly Pro His Phe Gln Gln Gln Gln Pro Leu Asn Leu 1025 1030 1035 1040 Ser Gln Ala Gln Gln His Ile Thr Thr Asp Arg Thr Gly Ser His Arg 1045 1050 1055 Arg Gln Gln Ala Tyr Ile Thr Pro Thr Met Ala Gln Ala Pro Tyr Ser 1060 1065 1070 Phe Pro His Asn Ser Pro Ser His Gly Thr Val His Pro His Leu Ala 1075 1080 1085 Ala Ala Ala Ala Ala Ala His Leu Pro Thr Gln Pro His Leu Tyr Thr 1090 1095 1100 Tyr Thr Ala Pro Ala Ala Leu Gly Ser Thr Gly Thr Val Ala His Leu 1105 1110 1115 1120 Val Ala Ser Gln Gly Ser Ala Arg His Thr Val Gln His Thr Ala Tyr 1125 1130 1135 Pro Ala Ser Ile Val His Gln Val Pro Val Ser Met Gly Pro Arg Val 1140 1145 1150 Leu Pro Ser Pro Thr Ile His Pro Ser Gln Tyr Pro Ala Gln Phe Ala 1155 1160 1165 His Gln Thr Tyr Ile Ser Ala Ser Pro Ala Ser Thr Val Tyr Thr Gly 1170 1175 1180 Tyr Pro Leu Ser Pro Ala Lys Val Asn Gln Tyr Pro Tyr Ile 1185 1190 1195 <210> SEQ ID NO 90 <211> LENGTH: 1022 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Met Arg Val Gln Leu Leu Gln Asp Leu Gln Asp Phe Phe Arg Lys Lys 1 5 10 15 Ala Glu Ile Glu Thr Glu Tyr Ser Arg Asn Leu Glu Lys Leu Ala Glu 20 25 30 Arg Phe Met Ala Lys Thr Arg Ser Thr Lys Asp His Gln Gln Tyr Lys 35 40 45 Lys Asp Gln Asn Leu Leu Ser Pro Val Asn Cys Trp Tyr Leu Leu Leu 50 55 60 Asn Gln Val Arg Arg Glu Ser Lys Asp His Ala Thr Leu Ser Asp Ile 65 70 75 80 Tyr Leu Asn Asn Val Ile Met Arg Phe Met Gln Ile Ser Glu Asp Ser 85 90 95 Thr Arg Met Phe Lys Lys Ser Lys Glu Ile Ala Phe Gln Leu His Glu 100 105 110 Asp Leu Met Lys Val Leu Asn Glu Leu Tyr Thr Val Met Lys Thr Tyr 115 120 125 His Met Tyr His Ala Glu Ser Ile Ser Ala Glu Ser Lys Leu Lys Glu 130 135 140 Ala Glu Lys Gln Glu Glu Lys Gln Ile Gly Arg Ser Gly Asp Pro Val 145 150 155 160 Phe His Ile Arg Leu Glu Glu Arg His Gln Arg Arg Ser Ser Val Lys 165 170 175 Lys Ile Glu Lys Met Lys Glu Lys Arg Gln Ala Lys Tyr Ser Glu Asn 180 185 190 Lys Leu Lys Ser Ile Lys Ala Arg Asn Glu Tyr Leu Leu Thr Leu Glu 195 200 205 Ala Thr Asn Ala Ser Val Phe Lys Tyr Tyr Ile His Asp Leu Ser Asp 210 215 220 Leu Ile Asp Cys Cys Asp Leu Gly Tyr His Ala Ser Leu Asn Arg Ala 225 230 235 240 Leu Arg Thr Tyr Leu Ser Ala Glu Tyr Asn Leu Glu Thr Ser Arg His 245 250 255 Glu Gly Leu Asp Ile Ile Glu Asn Ala Val Asp Asn Leu Glu Pro Arg 260 265 270 Ser Asp Lys Gln Arg Phe Met Glu Met Tyr Pro Ala Ala Phe Cys Pro 275 280 285 Pro Met Lys Phe Glu Phe Gln Ser His Met Gly Asp Glu Val Cys Gln 290 295 300 Val Ser Ala Gln Gln Pro Val Gln Ala Glu Leu Met Leu Arg Tyr Gln 305 310 315 320 Gln Leu Gln Ser Arg Leu Ala Thr Leu Lys Ile Glu Asn Glu Glu Val 325 330 335 Lys Lys Thr Thr Glu Ala Thr Leu Gln Thr Ile Gln Asp Met Val Thr 340 345 350 Ile Glu Asp Tyr Asp Val Ser Glu Cys Phe Gln His Ser Arg Ser Thr 355 360 365 Glu Ser Val Lys Ser Thr Val Ser Glu Thr Tyr Leu Ser Lys Pro Ser 370 375 380 Ile Ala Lys Arg Arg Ala Asn Gln Gln Glu Thr Glu Gln Phe Tyr Phe 385 390 395 400 Met Lys Leu Arg Glu Tyr Leu Glu Gly Ser Asn Leu Ile Thr Lys Leu 405 410 415 Gln Ala Lys His Asp Leu Leu Gln Arg Thr Leu Gly Glu Gly His Arg 420 425 430 Ala Glu Tyr Met Thr Thr Ser Arg Gly Arg Arg Asn Ser His Thr Arg 435 440 445 His Gln Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys Ile 450 455 460 Arg Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg Val 465 470 475 480 Ser Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu Arg 485 490 495 Gly Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn Ser 500 505 510 Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro Leu 515 520 525 Phe Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile Asp 530 535 540 Asn Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr Leu 545 550 555 560 Pro Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu Asn 565 570 575 His Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu 580 585 590 Ala Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln Asp 595 600 605 Gln Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile Ile 610 615 620 Ile His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly Pro 625 630 635 640 Val Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro Tyr 645 650 655 Ser Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr Glu 660 665 670 Pro His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala Lys 675 680 685 Phe Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys Gly 690 695 700 Ala Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu Gly 705 710 715 720 Arg His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val Val 725 730 735 Gln Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala Asp 740 745 750 Ser Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser Lys 755 760 765 Asp Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala Arg 770 775 780 Gln Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly Arg 785 790 795 800 Thr Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser Asn 805 810 815 Ser Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg Gly 820 825 830 Leu Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg Arg 835 840 845 Arg Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser Leu 850 855 860 Lys Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly Gln 865 870 875 880 Tyr Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile Ala 885 890 895 Gln Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg Glu 900 905 910 Leu Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu Asp 915 920 925 Thr Leu Glu Gln Val Lys Asn Ser Pro Thr Pro Ala Thr Ser Thr Glu 930 935 940 Ser Leu Ser Pro Leu His Asn Val Ala Leu Arg Ser Ser Glu Pro Gln 945 950 955 960 Ile Arg Arg Ser Thr Ser Ser Ser Ser Asp Thr Met Ser Thr Phe Lys 965 970 975 Pro Met Val Ala Pro Arg Met Gly Val Gln Leu Lys Pro Pro Ala Leu 980 985 990 Arg Pro Lys Pro Ala Val Leu Pro Lys Thr Asn Pro Thr Ile Gly Pro 995 1000 1005 Ala Pro Pro Pro Gln Gly Pro Thr Asp Lys Ser Cys Thr Met 1010 1015 1020 <210> SEQ ID NO 91 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 91 Met Ala Ala Ser Gly Arg Gly Leu Cys Lys Ala Val Ala Ala Ser Pro 1 5 10 15 Phe Pro Ala Trp Arg Arg Asp Asn Thr Glu Ala Arg Gly Gly Leu Lys 20 25 30 Pro Glu Tyr Asp Ala Val Val Ile Gly Ala Gly His Asn Gly Leu Val 35 40 45 Ala Ala Ala Tyr Leu Gln Arg Leu Gly Val Asn Thr Ala Val Phe Glu 50 55 60 Arg Arg His Val Ile Gly Gly Ala Ala Val Thr Glu Glu Ile Ile Pro 65 70 75 80 Gly Phe Lys Phe Ser Arg Ala Ser Tyr Leu Leu Ser Leu Leu Arg Pro 85 90 95 Gln Ile Tyr Thr Asp Leu Glu Leu Lys Lys His Gly Leu Arg Leu His 100 105 110 Leu Arg Asn Pro Tyr Ser Phe Thr Pro Met Leu Glu Glu Gly Ala Gly 115 120 125 Ser Lys Val Pro Arg Cys Leu Leu Leu Gly Thr Asp Met Ala Glu Asn 130 135 140 Gln Lys Gln Ile Ala Gln Phe Ser Gln Lys Asp Ala Gln Val Phe Pro 145 150 155 160 Lys Tyr Glu Glu Phe Met His Arg Leu Ala Leu Ala Ile Asp Pro Leu 165 170 175 Leu Asp Ala Ala Pro Val Asp Met Ala Ala Phe Gln His Gly Ser Leu 180 185 190 Leu Gln Arg Met Arg Ser Leu Ser Thr Leu Lys Pro Leu Leu Lys Ala 195 200 205 Gly Arg Ile Leu Gly Ala Gln Leu Pro Arg Tyr Tyr Glu Val Leu Thr 210 215 220 Ala Pro Ile Thr Lys Val Leu Asp Gln Trp Phe Glu Ser Glu Pro Leu 225 230 235 240 Lys Ala Thr Leu Ala Thr Asp Ala Val Ile Gly Ala Met Thr Ser Pro 245 250 255 His Thr Pro Gly Ser Gly Tyr Val Leu Leu His His Val Met Gly Gly 260 265 270 Leu Glu Gly Met Gln Gly Ala Trp Gly Tyr Val Gln Gly Gly Met Gly 275 280 285 Ala Leu Ser Asp Ala Ile Ala Ser Ser Ala Thr Thr His Gly Ala Ser 290 295 300 Ile Phe Thr Glu Lys Thr Val Ala Lys Val Gln Val Asn Ser Glu Gly 305 310 315 320 Cys Val Gln Gly Val Val Leu Glu Asp Gly Thr Glu Val Arg Ser Lys 325 330 335 Met Val Leu Ser Asn Thr Ser Pro Gln Ile Thr Phe Leu Lys Leu Thr 340 345 350 Pro Gln Glu Trp Leu Pro Glu Glu Phe Leu Glu Arg Ile Ser Gln Leu 355 360 365 Asp Thr Arg Ser Pro Val Thr Lys Ile Asn Val Ala Val Asp Arg Leu 370 375 380 Pro Ser Phe Leu Ala Ala Pro Asn Ala Pro Arg Gly Gln Pro Leu Pro 385 390 395 400 His His Gln Cys Ser Ile His Leu Asn Cys Glu Asp Thr Leu Leu Leu 405 410 415 His Gln Ala Phe Glu Asp Ala Met Asp Gly Leu Ser Ser His Arg Pro 420 425 430 Val Ile Glu Leu Cys Ile Pro Ser Ser Leu Asp Pro Thr Leu Ala Pro 435 440 445 Pro Gly Cys His Val Val Ser Leu Phe Thr Gln Tyr Thr Pro Tyr Thr 450 455 460 Leu Ala Gly Gly Lys Ala Trp Asp Glu Gln Glu Arg Asp Ala Tyr Ala 465 470 475 480 Asp Arg Val Phe Asp Cys Ile Glu Val Tyr Ala Pro Gly Phe Lys Asp 485 490 495 Ser Val Val Gly Arg Asp Ile Leu Thr Pro Pro Asp Leu Glu Arg Ile 500 505 510 Phe Gly Leu Pro Gly Gly Asn Ile Phe His Cys Ala Met Ser Leu Asp 515 520 525 Gln Leu Tyr Phe Ala Arg Pro Val Pro Leu His Ser Gly Tyr Arg Cys 530 535 540 Pro Leu Gln Gly Leu Tyr Leu Cys Gly Ser Gly Ala His Pro Gly Gly 545 550 555 560 Gly Val Met Gly Ala Ala Gly Arg Asn Ala Ala His Val Ala Phe Arg 565 570 575 Asp Leu Lys Ser Met 580 <210> SEQ ID NO 92 <211> LENGTH: 498 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 92 Met Pro Leu Val Thr Arg Asn Ile Glu Pro Arg His Leu Cys Arg Gln 1 5 10 15 Thr Leu Pro Ser Val Arg Ser Glu Leu Glu Cys Val Thr Asn Ile Thr 20 25 30 Leu Ala Asn Val Ile Arg Gln Leu Gly Ser Leu Ser Lys Tyr Ala Glu 35 40 45 Asp Ile Phe Gly Glu Leu Phe Thr Gln Ala Asn Thr Phe Ala Ser Arg 50 55 60 Val Ser Ser Leu Ala Glu Arg Val Asp Arg Leu Gln Val Lys Val Thr 65 70 75 80 Gln Leu Asp Pro Lys Glu Glu Glu Val Ser Leu Gln Gly Ile Asn Thr 85 90 95 Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Lys Leu Phe Asp 100 105 110 Arg Asn Ser Leu Pro Val Pro Val Leu Glu Thr Tyr Asn Thr Cys Asp 115 120 125 Thr Pro Pro Pro Leu Asn Asn Leu Thr Pro Tyr Arg Asp Asp Gly Lys 130 135 140 Glu Ala Leu Lys Phe Tyr Thr Asp Pro Ser Tyr Phe Phe Asp Leu Trp 145 150 155 160 Lys Glu Lys Met Leu Gln Asp Thr Lys Asp Ile Met Lys Glu Lys Arg 165 170 175 Lys His Arg Lys Glu Lys Lys Asp Asn Pro Asn Arg Gly Asn Val Asn 180 185 190 Pro Arg Lys Ile Lys Thr Arg Lys Glu Glu Trp Glu Lys Met Lys Met 195 200 205 Gly Gln Glu Phe Val Glu Ser Lys Glu Lys Leu Gly Thr Ser Gly Tyr 210 215 220 Pro Pro Thr Leu Val Tyr Gln Asn Gly Ser Ile Gly Cys Val Glu Asn 225 230 235 240 Val Asp Ala Ser Ser Tyr Pro Pro Pro Pro Gln Ser Asp Ser Ala Ser 245 250 255 Ser Pro Ser Pro Ser Phe Ser Glu Asp Asn Leu Pro Pro Pro Pro Ala 260 265 270 Glu Phe Ser Tyr Pro Val Asp Asn Gln Arg Gly Ser Gly Leu Ala Gly 275 280 285 Pro Lys Arg Ser Ser Val Val Ser Pro Ser His Pro Pro Pro Ala Pro 290 295 300 Pro Leu Gly Ser Pro Pro Gly Pro Lys Pro Gly Phe Ala Pro Pro Pro 305 310 315 320 Ala Pro Pro Pro Pro Pro Pro Pro Met Ile Gly Ile Pro Pro Pro Pro 325 330 335 Pro Pro Val Gly Phe Gly Ser Pro Gly Thr Pro Pro Pro Pro Ser Pro 340 345 350 Pro Ser Phe Pro Pro His Pro Asp Phe Ala Ala Pro Pro Pro Pro Pro 355 360 365 Pro Pro Pro Ala Ala Asp Tyr Pro Thr Leu Pro Pro Pro Pro Leu Ser 370 375 380 Gln Pro Thr Gly Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 385 390 395 400 Gly Pro Pro Pro Pro Pro Phe Thr Gly Ala Asp Gly Gln Pro Ala Ile 405 410 415 Pro Pro Pro Leu Ser Asp Thr Thr Lys Pro Lys Ser Ser Leu Pro Ala 420 425 430 Val Ser Asp Ala Arg Ser Asp Leu Leu Ser Ala Ile Arg Gln Gly Phe 435 440 445 Gln Leu Arg Arg Val Glu Glu Gln Arg Glu Gln Glu Lys Arg Asp Val 450 455 460 Val Gly Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu 465 470 475 480 Tyr Ser Asp Ser Glu Asp Asp Ser Ser Glu Phe Asp Glu Asp Asp Trp 485 490 495 Ser Asp <210> SEQ ID NO 93 <211> LENGTH: 1138 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 93 Met Ala Leu Lys Met Val Lys Gly Ser Ile Asp Arg Met Phe Asp Lys 1 5 10 15 Asn Leu Gln Asp Leu Val Arg Gly Ile Arg Asn His Lys Glu Asp Glu 20 25 30 Ala Lys Tyr Ile Ser Gln Cys Ile Asp Glu Ile Lys Gln Glu Leu Lys 35 40 45 Gln Asp Asn Ile Ala Val Lys Ala Asn Ala Val Cys Lys Leu Thr Tyr 50 55 60 Leu Gln Met Leu Gly Tyr Asp Ile Ser Trp Ala Ala Phe Asn Ile Ile 65 70 75 80 Glu Val Met Ser Ala Ser Lys Phe Thr Phe Lys Arg Ile Gly Tyr Leu 85 90 95 Ala Ala Ser Gln Ser Phe His Glu Gly Thr Asp Val Ile Met Leu Thr 100 105 110 Thr Asn Gln Ile Arg Lys Asp Leu Ser Ser Pro Ser Gln Tyr Asp Thr 115 120 125 Gly Val Ala Leu Thr Gly Leu Ser Cys Phe Val Thr Pro Asp Leu Ala 130 135 140 Arg Asp Leu Ala Asn Asp Ile Met Thr Leu Met Ser His Thr Lys Pro 145 150 155 160 Tyr Ile Arg Lys Lys Ala Val Leu Ile Met Tyr Lys Val Phe Leu Lys 165 170 175 Tyr Pro Glu Ser Leu Arg Pro Ala Phe Pro Arg Leu Lys Glu Lys Leu 180 185 190 Glu Asp Pro Asp Pro Gly Val Gln Ser Ala Ala Val Asn Val Ile Cys 195 200 205 Glu Leu Ala Arg Arg Asn Pro Lys Asn Tyr Leu Ser Leu Ala Pro Leu 210 215 220 Phe Phe Lys Leu Met Thr Ser Ser Thr Asn Asn Trp Val Leu Ile Lys 225 230 235 240 Ile Ile Lys Leu Phe Gly Ala Leu Thr Pro Leu Glu Pro Arg Leu Gly 245 250 255 Lys Lys Leu Ile Glu Pro Leu Thr Asn Leu Ile His Ser Thr Ser Ala 260 265 270 Met Ser Leu Leu Tyr Glu Cys Val Asn Thr Val Ile Ala Val Leu Ile 275 280 285 Ser Leu Ser Ser Gly Met Pro Asn His Ser Ala Ser Ile Gln Leu Cys 290 295 300 Val Gln Lys Leu Arg Ile Leu Ile Glu Asp Ser Asp Gln Asn Leu Lys 305 310 315 320 Tyr Leu Gly Leu Leu Ala Met Ser Lys Ile Leu Lys Thr His Pro Lys 325 330 335 Ser Val Gln Ser His Lys Asp Leu Ile Leu Gln Cys Leu Asp Asp Lys 340 345 350 Asp Glu Ser Ile Arg Leu Arg Ala Leu Asp Leu Leu Tyr Gly Met Val 355 360 365 Ser Lys Lys Asn Leu Met Glu Ile Val Lys Lys Leu Met Thr His Val 370 375 380 Asp Lys Ala Glu Gly Thr Thr Tyr Arg Asp Glu Leu Leu Thr Lys Ile 385 390 395 400 Ile Asp Ile Cys Ser Gln Ser Asn Tyr Gln Tyr Ile Thr Asn Phe Glu 405 410 415 Trp Tyr Ile Ser Ile Leu Val Glu Leu Thr Arg Leu Glu Gly Thr Arg 420 425 430 His Gly His Leu Ile Ala Ala Gln Met Leu Asp Val Ala Ile Arg Val 435 440 445 Lys Ala Ile Arg Lys Phe Ala Val Ser Gln Met Ser Ala Leu Leu Asp 450 455 460 Ser Ala His Leu Leu Ala Ser Ser Thr Gln Arg Asn Gly Ile Cys Glu 465 470 475 480 Val Leu Tyr Ala Ala Ala Trp Ile Cys Gly Glu Phe Ser Glu His Leu 485 490 495 Gln Glu Pro His His Thr Leu Glu Ala Met Leu Arg Pro Arg Val Thr 500 505 510 Thr Leu Pro Gly His Ile Gln Ala Val Tyr Val Gln Asn Val Val Lys 515 520 525 Leu Tyr Ala Ser Ile Leu Gln Gln Lys Glu Gln Ala Gly Glu Ala Glu 530 535 540 Gly Ala Gln Ala Val Thr Gln Leu Met Val Asp Arg Leu Pro Gln Phe 545 550 555 560 Val Gln Ser Ala Asp Leu Glu Val Gln Glu Arg Ala Ser Cys Ile Leu 565 570 575 Gln Leu Val Lys His Ile Gln Lys Leu Gln Ala Lys Asp Val Pro Val 580 585 590 Ala Glu Glu Val Ser Ala Leu Phe Ala Gly Glu Leu Asn Pro Val Ala 595 600 605 Pro Lys Ala Gln Lys Lys Val Pro Val Pro Glu Gly Leu Asp Leu Asp 610 615 620 Ala Trp Ile Asn Glu Pro Leu Ser Asp Ser Glu Ser Glu Asp Glu Arg 625 630 635 640 Pro Arg Ala Val Phe His Glu Glu Glu Gln Arg Arg Pro Lys His Arg 645 650 655 Pro Ser Glu Ala Asp Glu Glu Glu Leu Ala Arg Arg Arg Glu Ala Arg 660 665 670 Lys Gln Glu Gln Ala Asn Asn Pro Phe Tyr Ile Lys Ser Ser Pro Ser 675 680 685 Pro Gln Lys Arg Tyr Gln Asp Thr Pro Gly Val Glu His Ile Pro Val 690 695 700 Val Gln Ile Asp Leu Ser Val Pro Leu Lys Val Pro Gly Leu Pro Met 705 710 715 720 Ser Asp Gln Tyr Val Lys Leu Glu Glu Glu Arg Arg His Arg Gln Lys 725 730 735 Leu Glu Lys Asp Lys Arg Arg Lys Lys Arg Lys Glu Lys Glu Lys Lys 740 745 750 Gly Lys Arg Arg His Ser Ser Leu Pro Thr Glu Ser Asp Glu Asp Ile 755 760 765 Ala Pro Ala Gln Gln Val Asp Ile Val Thr Glu Glu Met Pro Glu Asn 770 775 780 Ala Leu Pro Ser Asp Glu Asp Asp Lys Asp Pro Asn Asp Pro Tyr Arg 785 790 795 800 Ala Leu Asp Ile Asp Leu Asp Lys Pro Leu Ala Asp Ser Glu Lys Leu 805 810 815 Pro Ile Gln Lys His Arg Asn Thr Glu Thr Ser Lys Ser Pro Glu Lys 820 825 830 Asp Val Pro Met Val Glu Lys Lys Ser Lys Lys Pro Lys Lys Lys Glu 835 840 845 Lys Lys His Lys Glu Lys Glu Arg Asp Lys Glu Lys Lys Lys Glu Lys 850 855 860 Glu Lys Lys Lys Ser Pro Lys Pro Lys Lys Lys Lys His Arg Lys Glu 865 870 875 880 Lys Glu Glu Arg Thr Lys Gly Lys Lys Lys Ser Lys Lys Gln Pro Pro 885 890 895 Gly Ser Glu Glu Ala Ala Gly Glu Pro Val Gln Asn Gly Ala Pro Glu 900 905 910 Glu Glu Gln Leu Pro Pro Glu Ser Ser Tyr Ser Leu Leu Ala Glu Asn 915 920 925 Ser Tyr Val Lys Met Thr Cys Asp Ile Arg Gly Ser Leu Gln Glu Asp 930 935 940 Ser Gln Val Thr Val Ala Ile Val Leu Glu Asn Arg Ser Ser Ser Ile 945 950 955 960 Leu Lys Gly Met Glu Leu Ser Val Leu Asp Ser Leu Asn Ala Arg Met 965 970 975 Ala Arg Pro Gln Gly Ser Ser Val His Asp Gly Val Pro Val Pro Phe 980 985 990 Gln Leu Pro Pro Gly Val Ser Asn Glu Ala Gln Tyr Val Phe Thr Ile 995 1000 1005 Gln Ser Ile Val Met Ala Gln Lys Leu Lys Gly Thr Leu Ser Phe Ile 1010 1015 1020 Ala Lys Asn Asp Glu Gly Ala Thr His Glu Lys Leu Asp Phe Arg Leu 102 1030 1035 1040 His Phe Ser Cys Ser Ser Tyr Leu Ile Thr Thr Pro Cys Tyr Ser Asp 1045 1050 1055 Ala Phe Ala Lys Leu Leu Glu Ser Gly Asp Leu Ser Met Ser Ser Ile 1060 1065 1070 Lys Val Asp Gly Ile Arg Met Ser Phe Gln Asn Leu Leu Ala Lys Ile 1075 1080 1085 Cys Phe His His His Phe Ser Val Val Glu Arg Val Asp Ser Cys Ala 1090 1095 1100 Ser Met Tyr Ser Arg Ser Ile Gln Gly His His Val Cys Leu Leu Val 1105 1110 1115 1120 Lys Lys Val Arg Thr Leu Ser Gln Ser Thr Gly Ser Ala Val Thr Pro 1125 1130 1135 Arg Tyr <210> SEQ ID NO 94 <211> LENGTH: 227 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 94 Met Phe Glu Pro Val Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Gly 1 5 10 15 Glu Ser Arg Glu Ala Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro 20 25 30 Arg Asp Ala Gln Leu Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala 35 40 45 Val Asn Thr His Cys His Ala Asp His Ile Thr Gly Ser Gly Leu Leu 50 55 60 Arg Ser Leu Leu Pro Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly 65 70 75 80 Ala Gln Ala Asp Leu His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly 85 90 95 Arg Phe Ala Leu Glu Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys 100 105 110 Val Thr Phe Val Leu Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala 115 120 125 Leu Leu Ile Arg Gly Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala 130 135 140 Lys Thr Leu Tyr His Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly 145 150 155 160 Asp Cys Leu Ile Tyr Pro Ala His Asp Tyr His Gly Phe Thr Val Ser 165 170 175 Thr Val Glu Glu Glu Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys 180 185 190 Glu Glu Phe Val Lys Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln 195 200 205 Gln Ile Asp Phe Ala Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr 210 215 220 Pro Thr Ala 225 <210> SEQ ID NO 95 <211> LENGTH: 640 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 95 Met His Val Lys Lys Tyr Leu Leu Lys Gly Leu His Arg Leu Gln Lys 1 5 10 15 Gly Pro Gly Tyr Thr Tyr Lys Glu Leu Leu Val Trp Tyr Cys Asp Asn 20 25 30 Thr Asn Thr His Gly Pro Lys Arg Ile Ile Cys Glu Gly Pro Lys Lys 35 40 45 Lys Ala Met Trp Phe Leu Leu Thr Leu Leu Phe Ala Ala Leu Val Cys 50 55 60 Trp Gln Trp Gly Ile Phe Ile Arg Thr Tyr Leu Ser Trp Glu Val Ser 65 70 75 80 Val Ser Leu Ser Val Gly Phe Lys Thr Met Asp Phe Pro Ala Val Thr 85 90 95 Ile Cys Asn Ala Ser Pro Phe Lys Tyr Ser Lys Ile Lys His Leu Leu 100 105 110 Lys Asp Leu Asp Glu Leu Met Glu Ala Val Leu Glu Arg Ile Leu Ala 115 120 125 Pro Glu Leu Ser His Ala Asn Ala Thr Arg Asn Leu Asn Phe Ser Ile 130 135 140 Trp Asn His Thr Pro Leu Val Leu Ile Asp Glu Arg Asn Pro His His 145 150 155 160 Pro Met Val Leu Asp Leu Phe Gly Asp Asn His Asn Gly Leu Thr Ser 165 170 175 Ser Ser Ala Ser Glu Lys Ile Cys Asn Ala His Gly Cys Lys Met Ala 180 185 190 Met Arg Leu Cys Ser Leu Asn Arg Thr Gln Cys Thr Phe Arg Asn Phe 195 200 205 Thr Ser Ala Thr Gln Ala Leu Thr Glu Trp Tyr Ile Leu Gln Ala Thr 210 215 220 Asn Ile Phe Ala Gln Val Pro Gln Gln Glu Leu Val Glu Met Ser Tyr 225 230 235 240 Pro Gly Glu Gln Met Ile Leu Ala Cys Leu Phe Gly Ala Glu Pro Cys 245 250 255 Asn Tyr Arg Asn Phe Thr Ser Ile Phe Tyr Pro His Tyr Gly Asn Cys 260 265 270 Tyr Ile Phe Asn Trp Gly Met Thr Glu Lys Ala Leu Pro Ser Ala Asn 275 280 285 Pro Gly Thr Glu Phe Gly Leu Lys Leu Ile Leu Asp Ile Gly Gln Glu 290 295 300 Asp Tyr Val Pro Phe Leu Ala Ser Thr Gly Gly Val Arg Leu Met Leu 305 310 315 320 His Glu Gln Arg Ser Tyr Pro Phe Ile Arg Asp Glu Gly Ile Tyr Ala 325 330 335 Met Ser Gly Thr Glu Thr Ser Ile Gly Val Leu Val Asp Lys Leu Gln 340 345 350 Arg Met Gly Glu Pro Tyr Ser Pro Cys Thr Val Asn Gly Ser Glu Val 355 360 365 Pro Val Gln Asn Phe Tyr Ser Asp Tyr Asn Thr Thr Tyr Ser Ile Gln 370 375 380 Ala Cys Leu Arg Ser Cys Phe Gln Asp His Met Ile Arg Asn Cys Asn 385 390 395 400 Cys Gly His Tyr Leu Tyr Pro Leu Pro Arg Gly Glu Lys Tyr Cys Asn 405 410 415 Asn Arg Asp Phe Pro Asp Trp Ala His Cys Tyr Ser Asp Leu Gln Met 420 425 430 Ser Val Ala Gln Arg Glu Thr Cys Ile Gly Met Cys Lys Glu Ser Cys 435 440 445 Asn Asp Thr Gln Tyr Lys Met Thr Ile Ser Met Ala Asp Trp Pro Ser 450 455 460 Glu Ala Ser Glu Asp Trp Ile Phe His Val Leu Ser Gln Glu Arg Asp 465 470 475 480 Gln Ser Thr Asn Ile Thr Leu Ser Arg Lys Gly Ile Val Lys Leu Asn 485 490 495 Ile Tyr Phe Gln Glu Phe Asn Tyr Arg Thr Ile Glu Glu Ser Ala Ala 500 505 510 Asn Asn Ile Val Trp Leu Leu Ser Asn Leu Gly Gly Gln Phe Gly Phe 515 520 525 Trp Met Gly Gly Ser Val Leu Cys Leu Ile Glu Phe Gly Glu Ile Ile 530 535 540 Ile Asp Phe Val Trp Ile Thr Ile Ile Lys Leu Val Ala Leu Ala Lys 545 550 555 560 Ser Leu Arg Gln Arg Arg Ala Gln Ala Ser Tyr Ala Gly Pro Pro Pro 565 570 575 Thr Val Ala Glu Leu Val Glu Ala His Thr Asn Phe Gly Phe Gln Pro 580 585 590 Asp Thr Ala Pro Arg Ser Pro Asn Thr Gly Pro Tyr Pro Ser Glu Gln 595 600 605 Ala Leu Pro Ile Pro Gly Thr Pro Pro Pro Asn Tyr Asp Ser Leu Arg 610 615 620 Leu Gln Pro Leu Asp Val Ile Glu Ser Asp Ser Glu Gly Asp Ala Ile 625 630 635 640 <210> SEQ ID NO 96 <211> LENGTH: 1498 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 96 Val Lys Asp Leu Gly Ser Leu Asn Gly Thr Phe Val Asn Asp Met Arg 1 5 10 15 Ile Pro Asp Gln Lys Tyr Val Thr Leu Lys Leu Asn Asp Val Ile Arg 20 25 30 Phe Gly Tyr Asp Ser Asn Met Tyr Val Leu Glu Arg Val Gln His Arg 35 40 45 Val Pro Glu Glu Ala Leu Lys His Glu Lys Tyr Thr Ser Gln Leu Gln 50 55 60 Val Ser Val Lys Gly Leu Ala Pro Lys Arg Ser Glu Ala Leu Pro Glu 65 70 75 80 His Thr Pro Tyr Cys Glu Ala Ser Asn Pro Arg Pro Glu Lys Gly Asp 85 90 95 Arg Arg Pro Gly Thr Glu Ala Ala Ser Tyr Arg Thr Pro Leu Tyr Gly 100 105 110 Gln Pro Ser Trp Trp Gly Glu Asp Asp Gly Ser Thr Leu Pro Asp Ala 115 120 125 Gln Arg Gln Gly Glu Pro Tyr Pro Glu Arg Pro Lys Gly Pro Val Gln 130 135 140 Gln Asp Gly Glu Leu His Gly Phe Arg Ala Pro Ala Glu Pro Gln Gly 145 150 155 160 Cys Ser Phe Arg Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr Lys Glu 165 170 175 Thr Pro Gln Pro Ser Gln Pro Pro Glu Val Pro Ala His Glu Met Pro 180 185 190 Thr Lys Asp Ala Glu Ala Gly Gly Gly Gly Ala Ala Pro Val Val Gln 195 200 205 Ser His Ala Ser Phe Thr Ile Glu Phe Asp Asp Cys Ser Pro Gly Lys 210 215 220 Met Lys Ile Lys Asp His Ile Thr Lys Phe Ser Leu Arg Gln Arg Arg 225 230 235 240 Pro Pro Gly Lys Glu Ala Thr Pro Gly Glu Met Val Ser Ala Glu Thr 245 250 255 Lys Val Ala Asp Trp Leu Val Gln Asn Asp Pro Ser Leu Leu His Arg 260 265 270 Val Gly Pro Gly Asp Asp Arg His Ser Thr Lys Ser Asp Leu Pro Val 275 280 285 His Thr Arg Thr Leu Lys Gly His Lys His Glu Asp Gly Thr Gln Ser 290 295 300 Asp Ser Glu Asp Pro Leu Ala Lys Ala Ala Ser Ala Ala Gly Val Pro 305 310 315 320 Leu Glu Ala Ser Gly Gly Gln Val Arg Leu Gln Arg Gln Ile Lys Arg 325 330 335 Asp Pro Gln Glu Leu Leu His Asn Gln Gln Ala Phe Val Ile Glu Phe 340 345 350 Phe Asp Glu Asp Thr Pro Arg Lys Lys Arg Ser Gln Ser Phe Thr His 355 360 365 Ser Pro Ser Gly Asp Pro Lys Ala Asp Lys Arg Arg Gly Pro Thr Pro 370 375 380 Ala Asp Arg Asp Arg Pro Ser Val Pro Ala Pro Val Gln Ala Gly Gly 385 390 395 400 Arg Ser Ser Gly Pro Gln Arg Ala Gly Ser Leu Lys Arg Glu Lys Thr 405 410 415 Glu Glu Arg Leu Gly Ser Pro Ser Pro Ala Ser Arg Thr Pro Ala Arg 420 425 430 Pro Phe Gly Ser Val Gly Arg Arg Ser Arg Leu Ala Gln Asp Phe Met 435 440 445 Ala Gln Cys Leu Arg Glu Ser Ser Pro Ala Ala Arg Pro Ser Pro Glu 450 455 460 Lys Val Pro Pro Val Leu Pro Ala Pro Leu Thr Pro His Gly Thr Ser 465 470 475 480 Pro Val Gly Pro Pro Thr Pro Pro Pro Ala Pro Thr Asp Pro Gln Leu 485 490 495 Thr Lys Ala Arg Lys Gln Glu Glu Asp Asp Ser Leu Ser Asp Ala Gly 500 505 510 Thr Tyr Thr Ile Glu Thr Glu Ala Gln Asp Thr Glu Val Glu Glu Ala 515 520 525 Arg Lys Met Ile Asp Gln Val Phe Gly Val Leu Glu Ser Pro Glu Leu 530 535 540 Ser Arg Ala Ser Ser Ala Thr Phe Arg Pro Val Ile Arg Gly Asp Arg 545 550 555 560 Asp Glu Ser Asp Asp Gly Gly Val Ala Gln Arg Met Ala Leu Leu Gln 565 570 575 Glu Phe Ala Ser Arg Pro Leu Gly Ala Ala Pro Gln Ala Glu His Gln 580 585 590 Gly Leu Pro Val Pro Gly Ser Pro Gly Gly Gln Lys Trp Val Ser Arg 595 600 605 Trp Ala Ser Leu Ala Asp Ser Tyr Ser Asp Pro Gly Leu Thr Glu Asp 610 615 620 Gly Leu Gly Arg Arg Gly Gly Glu Pro Glu Gly Ser Leu Pro Val Arg 625 630 635 640 Met Arg Arg Arg Leu Pro Gln Leu Pro Ser Glu Arg Ala Asp Ser Pro 645 650 655 Ala Gly Pro Glu Ser Ser Arg Arg Ser Gly Pro Gly Pro Pro Glu Leu 660 665 670 Asp Ser Glu Gln Pro Ser Arg Leu Phe Gly Gln Glu Glu Leu Asp Pro 675 680 685 Asp Ser Leu Ser Asp Ala Ser Gly Ser Asp Gly Gly Arg Gly Pro Glu 690 695 700 Pro Gly Val Glu Pro Gln Asp Ser Arg Arg Arg Ser Pro Gln Glu Gly 705 710 715 720 Pro Thr Trp Ser Arg Gly Arg Arg Ser Pro Arg Ala Pro Gly Glu Pro 725 730 735 Thr Pro Ala Ser Phe Phe Ile Gly Asp Gln Asn Gly Asp Ala Val Leu 740 745 750 Ser Arg Lys Leu Leu Ala Ala Pro Gly Asp Gly Glu Gly Leu Gly Gln 755 760 765 Thr Ala Gln Pro Ser Pro Pro Ala Arg Asp Gly Val Tyr Val Ser Ala 770 775 780 Asn Gly Arg Met Val Ile Gln Leu Arg Pro Gly Arg Ser Pro Glu Pro 785 790 795 800 Asp Gly Pro Ala Pro Ala Phe Leu Arg Gln Glu Ser Phe Thr Lys Glu 805 810 815 Pro Ala Ser Gly Pro Pro Ala Pro Gly Lys Pro Pro His Ile Ser Ser 820 825 830 His Pro Leu Leu Gln Asp Leu Ala Ala Thr Arg Ala Ala Arg Met Asp 835 840 845 Phe His Ser Gln Asp Thr His Leu Ile Leu Lys Glu Thr Glu Thr Ala 850 855 860 Leu Ala Ala Leu Glu Ala Arg Leu Leu Ser Asn Ser Val Asp Ala Glu 865 870 875 880 Cys Glu Gly Gly Ser Thr Pro Arg Pro Pro Glu Asp Ala Leu Ser Gly 885 890 895 Asp Ser Asp Val Asp Thr Ala Ser Thr Val Ser Leu Arg Ser Gly Lys 900 905 910 Ser Gly Pro Ser Pro Thr Thr Pro Gln Pro Leu Arg Ala Gln Lys Glu 915 920 925 Met Ser Pro Ser Pro Pro Ala Ala Gln Asp Pro Gly Gly Thr Ala Leu 930 935 940 Val Ser Ala Arg Glu Gln Ser Ser Glu Arg Gln His His Pro Leu Gly 945 950 955 960 Pro Thr Asp Met Gly Arg Gly Glu Pro Val Arg Arg Ser Ala Ile Arg 965 970 975 Arg Gly His Arg Pro Arg Gly Ser Leu Asp Trp Pro Ser Glu Glu Arg 980 985 990 Gly Pro Val Leu Ala His Leu Pro Ser Ser Asp Val Met Ala Ser Asn 995 1000 1005 His Glu Thr Pro Glu Ala Thr Gly Ala Gly Arg Leu Gly Ser Arg Arg 1010 1015 1020 Lys Pro Ala Ala Pro Pro Pro Ser Pro Ala Ala Arg Glu Glu Gln Ser 1025 1030 1035 1040 Arg Ser Ser Ala Ser Ser Gln Lys Gly Pro Gln Ala Leu Thr Arg Ser 1045 1050 1055 Asn Ser Leu Ser Thr Pro Arg Pro Thr Arg Ala Ser Arg Leu Arg Arg 1060 1065 1070 Ala Arg Leu Gly Asp Ala Ser Asp Thr Glu Ala Ala Asp Gly Glu Arg 1075 1080 1085 Gly Ser Leu Gly Asn Pro Glu Pro Val Gly Arg Pro Ala Ala Glu Gln 1090 1095 1100 Ala Lys Lys Leu Ser Arg Leu Asp Ile Leu Ala Met Pro Arg Lys Arg 1105 1110 1115 1120 Ala Gly Ser Phe Thr Gly Thr Ser Asp Pro Glu Ala Ala Pro Ala Arg 1125 1130 1135 Thr Ser Phe Ser Gly Arg Ser Val Glu Leu Cys Cys Ala Ser Arg Lys 1140 1145 1150 Pro Thr Met Ala Glu Ala Arg Ala Val Ser Arg Lys Ala Ala Asn Thr 1155 1160 1165 Ala Thr Thr Thr Gly Pro Arg Gln Pro Phe Ser Arg Ala Arg Ser Gly 1170 1175 1180 Ser Ala Arg Tyr Thr Ser Thr Thr Gln Thr Pro Arg Ala Gly Ser Ser 1185 1190 1195 1200 Ser Arg Ala Arg Ser Arg Ala Pro Gly Pro Arg Asp Thr Asp Asp Asp 1205 1210 1215 Glu Glu Glu Pro Asp Pro Tyr Gly Phe Ile Val Gln Thr Ala Glu Ile 1220 1225 1230 Ala Glu Ile Ala Arg Leu Ser Gln Thr Leu Val Lys Asp Val Ala Ile 1235 1240 1245 Leu Ala Gln Glu Ile His Asp Val Ala Gly Asp Gly Asp Thr Leu Gly 1250 1255 1260 Ser Ser Glu Pro Ala His Ser Ala Ser Leu Ser Asn Met Pro Ser Thr 1265 1270 1275 1280 Pro Ala Ser Thr Ile Ser Ala Arg Glu Glu Leu Val Gln Arg Ile Pro 1285 1290 1295 Glu Ala Ser Leu Asn Phe Gln Lys Val Pro Pro Gly Ser Leu Asn Ser 1300 1305 1310 Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu Asp Ala Leu Ala 1315 1320 1325 Asn Lys Thr Arg Pro Arg Asn Arg Glu Glu Val Ile Phe Asp Asn Leu 1330 1335 1340 Met Leu Asn Pro Val Ser Gln Leu Ser Gln Ala Ile Arg Glu Asn Thr 1345 1350 1355 1360 Glu His Leu Ala Glu Lys Met Lys Ile Leu Phe Gln Asn Thr Gly Arg 1365 1370 1375 Ala Trp Glu Asp Leu Glu Ala Arg Ile Asn Ala Glu Asn Glu Val Pro 1380 1385 1390 Ile Leu Lys Thr Ser Asn Lys Glu Ile Ser Ser Ile Leu Lys Glu Leu 1395 1400 1405 Arg Arg Val Gln Lys Gln Leu Glu Val Ile Asn Ala Ile Val Asp Pro 1410 1415 1420 Ser Gly Ser Leu Asp Leu Leu Thr Gly Asn Arg Ser Leu Ala Ser Ser 1425 1430 1435 1440 Ala Gln Pro Gly Leu Gly Lys Gly Arg Val Ala Ala Gln Ser Pro Pro 1445 1450 1455 Ser Pro Ala Ser Ala Glu Ala Leu Leu Pro Ala Leu Pro Leu Arg Asn 1460 1465 1470 Phe Pro Gln Arg Ala Ser Cys Gly Pro Pro Ser Leu Pro Asp Pro Thr 1475 1480 1485 Phe Leu Pro Asp Ala Glu Arg Phe Leu Ile 1490 1495 <210 > SEQ ID NO 97 <211> LENGTH: 622 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 97 Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 1 5 10 15 Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 20 25 30 Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 35 40 45 Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 50 55 60 Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 65 70 75 80 Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 85 90 95 Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 100 105 110 Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 115 120 125 Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 130 135 140 Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 145 150 155 160 Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 165 170 175 Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 180 185 190 Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 195 200 205 Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 210 215 220 Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 225 230 235 240 His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 245 250 255 Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 260 265 270 Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 275 280 285 Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 290 295 300 Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 305 310 315 320 Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 325 330 335 Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 340 345 350 Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 355 360 365 Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 370 375 380 Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 385 390 395 400 Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 405 410 415 Glu Lys Leu Ser Ala Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 420 425 430 Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 435 440 445 Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 450 455 460 Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 465 470 475 480 Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 485 490 495 Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 500 505 510 Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 515 520 525 Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 530 535 540 Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 545 550 555 560 Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 565 570 575 Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 580 585 590 Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 595 600 605 Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 610 615 620 <210> SEQ ID NO 98 <211> LENGTH: 568 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 98 Met Ala Ser Ser Cys Ala Val Gln Val Lys Leu Glu Leu Gly His Arg 1 5 10 15 Ala Gln Val Arg Lys Lys Pro Thr Val Glu Gly Phe Thr His Asp Trp 20 25 30 Met Val Phe Val Arg Gly Pro Glu His Ser Asn Ile Gln His Phe Val 35 40 45 Glu Lys Val Val Phe His Leu His Glu Ser Phe Pro Arg Pro Lys Arg 50 55 60 Val Cys Lys Asp Pro Pro Tyr Lys Val Glu Glu Ser Gly Tyr Ala Gly 65 70 75 80 Phe Ile Leu Pro Ile Glu Val Tyr Phe Lys Asn Lys Glu Glu Pro Arg 85 90 95 Lys Val Arg Phe Asp Tyr Asp Leu Phe Leu His Leu Glu Gly His Pro 100 105 110 Pro Val Asn His Leu Arg Cys Glu Lys Leu Thr Phe Asn Asn Pro Thr 115 120 125 Glu Asp Phe Arg Arg Lys Leu Leu Lys Ala Gly Gly Asp Pro Asn Arg 130 135 140 Ser Ile His Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 145 150 155 160 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 165 170 175 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser 180 185 190 Phe Ser Lys Pro His Lys Leu Met Lys Glu His Lys Glu Lys Pro Ser 195 200 205 Lys Asp Ser Arg Glu His Lys Ser Ala Phe Lys Glu Pro Ser Arg Asp 210 215 220 His Asn Lys Ser Ser Lys Glu Ser Ser Lys Lys Pro Lys Glu Asn Lys 225 230 235 240 Pro Leu Lys Glu Glu Lys Ile Val Pro Lys Met Ala Phe Lys Glu Pro 245 250 255 Lys Pro Met Ser Lys Glu Pro Lys Pro Asp Ser Asn Leu Leu Thr Ile 260 265 270 Thr Ser Gly Gln Asp Lys Lys Ala Pro Ser Lys Arg Pro Pro Ile Ser 275 280 285 Asp Ser Glu Glu Leu Ser Ala Lys Lys Arg Lys Lys Ser Ser Ser Glu 290 295 300 Ala Leu Phe Lys Ser Phe Ser Ser Ala Pro Pro Leu Ile Leu Thr Cys 305 310 315 320 Ser Ala Asp Lys Lys Gln Ile Lys Asp Lys Ser His Val Lys Met Gly 325 330 335 Lys Val Lys Ile Glu Ser Glu Thr Ser Glu Lys Lys Lys Ser Thr Leu 340 345 350 Pro Pro Phe Asp Asp Ile Val Asp Pro Asn Asp Ser Asp Val Glu Glu 355 360 365 Asn Ile Ser Ser Lys Ser Asp Ser Glu Gln Pro Ser Pro Ala Ser Ser 370 375 380 Ser Ser Ser Ser Ser Ser Ser Phe Thr Pro Ser Gln Thr Arg Gln Gln 385 390 395 400 Gly Pro Leu Arg Ser Ile Met Lys Asp Leu His Ser Asp Asp Asn Glu 405 410 415 Glu Glu Ser Asp Glu Val Glu Asp Asn Asp Asn Asp Ser Glu Met Glu 420 425 430 Arg Pro Val Asn Arg Gly Gly Ser Arg Ser Arg Arg Val Ser Leu Ser 435 440 445 Asp Gly Ser Asp Ser Glu Ser Ser Ser Ala Ser Ser Pro Leu His His 450 455 460 Glu Pro Pro Pro Pro Leu Leu Lys Thr Asn Asn Asn Gln Ile Leu Glu 465 470 475 480 Val Lys Ser Pro Ile Lys Gln Ser Lys Ser Asp Lys Gln Ile Lys Asn 485 490 495 Gly Glu Cys Asp Lys Ala Tyr Leu Asp Glu Leu Val Glu Leu His Arg 500 505 510 Arg Leu Met Thr Leu Arg Glu Arg His Ile Leu Gln Gln Ile Val Asn 515 520 525 Leu Ile Glu Glu Thr Gly His Phe His Ile Thr Asn Thr Thr Phe Asp 530 535 540 Phe Asp Leu Cys Ser Leu Asp Lys Thr Thr Val Arg Lys Leu Gln Ser 545 550 555 560 Tyr Leu Glu Thr Ser Gly Thr Ser 565 <210> SEQ ID NO 99 <211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 99 Met Leu Leu Gly Leu Ala Ala Met Glu Leu Lys Val Trp Val Asp Gly 1 5 10 15 Ile Gln Arg Val Val Cys Gly Val Ser Glu Gln Thr Thr Cys Gln Glu 20 25 30 Val Val Ile Ala Leu Ala Gln Ala Ile Gly Gln Thr Gly Arg Phe Val 35 40 45 Leu Val Gln Arg Leu Arg Glu Lys Glu Arg Gln Leu Leu Pro Gln Glu 50 55 60 Cys Pro Val Gly Ala Gln Ala Thr Cys Gly Gln Phe Ala Ser Asp Val 65 70 75 80 Gln Phe Val Leu Arg Arg Thr Gly Pro Ser Leu Ala Gly Arg Pro Ser 85 90 95 Ser Asp Ser Cys Pro Pro Pro Glu Arg Cys Leu Ile Arg Ala Ser Leu 100 105 110 Pro Val Lys Pro Arg Ala Ala Leu Gly Cys Glu Pro Arg Lys Thr Leu 115 120 125 Thr Pro Glu Pro Ala Pro Ser Leu Ser Arg Pro Gly Pro Ala Ala Pro 130 135 140 Val Thr Pro Thr Pro Gly Cys Cys Thr Asp Leu Arg Gly Leu Glu Leu 145 150 155 160 Arg Val Gln Arg Asn Ala Glu Glu Leu Gly His Glu Ala Phe Trp Glu 165 170 175 Gln Glu Leu Arg Arg Glu Gln Ala Arg Glu Arg Glu Gly Gln Ala Arg 180 185 190 Leu Gln Ala Leu Ser Ala Ala Thr Ala Glu His Ala Ala Arg Leu Gln 195 200 205 Ala Leu Asp Ala Gln Ala Arg Ala Leu Glu Ala Glu Leu Gln Leu Ala 210 215 220 Ala Glu Ala Pro Gly Pro Pro Ser Pro Met Ala Ser Ala Thr Glu Arg 225 230 235 240 Leu His Gln Asp Leu Ala Val Gln Glu Arg Gln Ser Ala Glu Val Gln 245 250 255 Gly Ser Leu Ala Leu Val Ser Arg Ala Leu Glu Ala Ala Glu Arg Ala 260 265 270 Leu Gln Ala Gln Ala Gln Glu Leu Glu Glu Leu Asn Arg Glu Leu Arg 275 280 285 Gln Cys Asn Leu Gln Gln Phe Ile Gln Gln Thr Gly Ala Ala Leu Pro 290 295 300 Pro Pro Pro Arg Pro Asp Arg Gly Pro Pro Gly Thr Gln Gly Pro Leu 305 310 315 320 Pro Pro Ala Arg Glu Glu Ser Leu Leu Gly Ala Pro Ser Glu Ser His 325 330 335 Ala Gly Ala Gln Pro Arg Pro Arg Gly Gly Pro His Asp Ala Glu Leu 340 345 350 Leu Glu Val Ala Ala Ala Pro Ala Pro Glu Trp Cys Pro Leu Ala Ala 355 360 365 Gln Pro Gln Ala Leu 370 <210> SEQ ID NO 100 <211> LENGTH: 334 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 100 Met Lys Pro Pro Pro Arg Arg Arg Ala Ala Pro Ala Arg Tyr Leu Gly 1 5 10 15 Glu Val Thr Gly Pro Ala Thr Trp Ser Ala Arg Glu Lys Arg Gln Leu 20 25 30 Val Arg Leu Leu Gln Ala Arg Gln Gly Gln Pro Glu Pro Asp Ala Thr 35 40 45 Glu Leu Ala Arg Glu Leu Arg Gly Arg Ser Glu Ala Glu Ile Arg Val 50 55 60 Phe Leu Gln Gln Leu Lys Gly Arg Val Ala Arg Glu Ala Ile Gln Lys 65 70 75 80 Val His Pro Gly Gly Leu Gln Gly Pro Arg Arg Arg Glu Ala Gln Pro 85 90 95 Pro Ala Pro Ile Glu Val Trp Thr Asp Leu Ala Glu Lys Ile Thr Gly 100 105 110 Pro Leu Glu Glu Ala Leu Ala Val Ala Phe Ser Gln Val Leu Thr Ile 115 120 125 Ala Ala Thr Glu Pro Val Thr Leu Leu His Ser Lys Pro Pro Lys Pro 130 135 140 Thr Gln Ala Arg Gly Lys Pro Leu Leu Leu Ser Ala Pro Gly Gly Gln 145 150 155 160 Glu Asp Pro Ala Pro Glu Ile Pro Ser Ser Ala Pro Ala Ala Pro Ser 165 170 175 Ser Ala Pro Arg Thr Pro Asp Pro Ala Pro Glu Lys Pro Ser Glu Ser 180 185 190 Ser Ala Gly Pro Ser Thr Glu Glu Asp Phe Ala Val Asp Phe Glu Lys 195 200 205 Ile Tyr Lys Tyr Leu Ser Ser Val Ser Arg Ser Gly Arg Ser Pro Glu 210 215 220 Leu Ser Ala Ala Glu Ser Ala Val Val Leu Asp Leu Leu Met Ser Leu 225 230 235 240 Pro Glu Glu Leu Pro Leu Leu Pro Cys Thr Ala Leu Val Glu His Met 245 250 255 Thr Glu Thr Tyr Leu Arg Leu Thr Ala Pro Gln Pro Ile Pro Ala Gly 260 265 270 Gly Ser Leu Gly Pro Ala Ala Glu Gly Asp Gly Ala Gly Ser Lys Ala 275 280 285 Pro Glu Glu Thr Pro Pro Ala Thr Glu Lys Ala Glu His Ser Glu Leu 290 295 300 Lys Ser Pro Trp Gln Ala Ala Gly Ile Cys Pro Leu Asn Pro Phe Leu 305 310 315 320 Val Pro Leu Glu Leu Leu Gly Arg Ala Ala Thr Pro Ala Arg 325 330 <210> SEQ ID NO 101 <211> LENGTH: 1233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 101 Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 1 5 10 15 Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 20 25 30 Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 35 40 45 Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 50 55 60 Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 65 70 75 80 Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 85 90 95 Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 100 105 110 Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 115 120 125 Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 130 135 140 Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 145 150 155 160 Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 165 170 175 Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 180 185 190 Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 195 200 205 Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 210 215 220 Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 225 230 235 240 Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 245 250 255 Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 260 265 270 Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 275 280 285 Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 290 295 300 Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 305 310 315 320 Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 325 330 335 Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 340 345 350 Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 355 360 365 Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 370 375 380 Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 385 390 395 400 Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 405 410 415 Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 420 425 430 Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 435 440 445 Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 450 455 460 Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 465 470 475 480 Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 485 490 495 Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 500 505 510 Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 515 520 525 Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 530 535 540 Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 545 550 555 560 Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 565 570 575 Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 580 585 590 Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 595 600 605 Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 610 615 620 Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 625 630 635 640 Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 645 650 655 Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 660 665 670 Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 675 680 685 Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 690 695 700 Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 705 710 715 720 Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 725 730 735 Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 740 745 750 Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 755 760 765 Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 770 775 780 Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 785 790 795 800 Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 805 810 815 Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 820 825 830 Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 835 840 845 Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 850 855 860 Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 865 870 875 880 Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 885 890 895 Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 900 905 910 Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 915 920 925 Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 930 935 940 Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 945 950 955 960 Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 965 970 975 Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 980 985 990 Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 995 1000 1005 Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 1010 1015 1020 Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 1025 1030 1035 1040 Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 1045 1050 1055 Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 1060 1065 1070 Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 1075 1080 1085 Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 1090 1095 1100 Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 1105 1110 1115 1120 Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 1125 1130 1135 Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 1140 1145 1150 Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 1155 1160 1165 Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 1170 1175 1180 Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 1185 1190 1195 1200 Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 1205 1210 1215 Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 1220 1225 1230 Gln <210> SEQ ID NO 102 <211> LENGTH: 749 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 102 Met Ala Arg Lys Leu Ser Val Ile Leu Ile Leu Thr Phe Ala Leu Ser 1 5 10 15 Val Thr Asn Pro Leu His Glu Leu Lys Ala Ala Ala Phe Pro Gln Thr 20 25 30 Thr Glu Lys Ile Ser Pro Asn Trp Glu Ser Gly Ile Asn Val Asp Leu 35 40 45 Ala Ile Ser Thr Arg Gln Tyr His Leu Gln Gln Leu Phe Tyr Arg Tyr 50 55 60 Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys Leu Leu Gln 65 70 75 80 Asn Ile Gly Ile Asp Lys Ile Lys Arg Ile His Ile His His Asp His 85 90 95 Asp His His Ser Asp His Glu His His Ser Asp His Glu Arg His Ser 100 105 110 Asp His Glu His His Ser Asp His Glu His His Ser Asp His Asn His 115 120 125 Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala Leu Cys Pro Asp His Asp 130 135 140 Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn Ser Gln Gly Lys Gly Ala 145 150 155 160 His Arg Pro Glu His Ala Ser Gly Arg Arg Asn Val Lys Asp Ser Val 165 170 175 Ser Ala Ser Glu Val Thr Ser Thr Val Tyr Asn Thr Val Ser Glu Gly 180 185 190 Thr His Phe Leu Glu Thr Ile Glu Thr Pro Arg Pro Gly Lys Leu Phe 195 200 205 Pro Lys Asp Val Ser Ser Ser Thr Pro Pro Ser Val Thr Ser Lys Ser 210 215 220 Arg Val Ser Arg Leu Ala Gly Arg Lys Thr Asn Glu Ser Val Ser Glu 225 230 235 240 Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn Thr Asn Glu Asn Pro Gln 245 250 255 Glu Cys Phe Asn Ala Ser Lys Leu Leu Thr Ser His Gly Met Gly Ile 260 265 270 Gln Val Pro Leu Asn Ala Thr Glu Phe Asn Tyr Leu Cys Pro Ala Ile 275 280 285 Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu Ile His Thr Ser Glu Lys 290 295 300 Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser Leu Gln Ile Ala Trp Val 305 310 315 320 Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser Phe Leu Ser Leu Leu Gly 325 330 335 Val Ile Leu Val Pro Leu Met Asn Arg Val Phe Phe Lys Phe Leu Leu 340 345 350 Ser Phe Leu Val Ala Leu Ala Val Gly Thr Leu Ser Gly Asp Ala Phe 355 360 365 Leu His Leu Leu Pro His Ser His Ala Ser His His His Ser His Ser 370 375 380 His Glu Glu Pro Ala Met Glu Met Lys Arg Gly Pro Leu Phe Ser His 385 390 395 400 Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala Tyr Phe Asp Ser Thr Trp 405 410 415 Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr Phe Met Phe Leu Val Glu 420 425 430 His Val Leu Thr Leu Ile Lys Gln Phe Lys Asp Lys Lys Lys Lys Asn 435 440 445 Gln Lys Lys Pro Glu Asn Asp Asp Asp Val Glu Ile Lys Lys Gln Leu 450 455 460 Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn Glu Glu Lys Val Asp Thr 465 470 475 480 Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala Asp Ser Gln Glu Pro Ser 485 490 495 His Phe Asp Ser Gln Gln Pro Ala Val Leu Glu Glu Glu Glu Val Met 500 505 510 Ile Ala His Ala His Pro Gln Glu Val Tyr Asn Glu Tyr Val Pro Arg 515 520 525 Gly Cys Lys Asn Lys Cys His Ser His Phe His Asp Thr Leu Gly Gln 530 535 540 Ser Asp Asp Leu Ile His His His His Asp Tyr His His Ile Leu His 545 550 555 560 His His His His Gln Asn His His Pro His Ser His Ser Gln Arg Tyr 565 570 575 Ser Arg Glu Glu Leu Lys Asp Ala Gly Val Ala Thr Leu Ala Trp Met 580 585 590 Val Ile Met Gly Asp Gly Leu His Asn Phe Ser Asp Gly Leu Ala Ile 595 600 605 Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser Gly Leu Ser Thr Ser Val 610 615 620 Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 625 630 635 640 Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Val Leu Tyr Asn Ala 645 650 655 Leu Ser Ala Met Leu Ala Tyr Leu Gly Met Ala Thr Gly Ile Phe Ile 660 665 670 Gly His Tyr Ala Glu Asn Val Ser Met Trp Ile Phe Ala Leu Thr Ala 675 680 685 Gly Leu Phe Met Tyr Val Ala Leu Val Asp Met Val Pro Glu Met Leu 690 695 700 His Asn Asp Ala Ser Asp His Gly Cys Ser Arg Trp Gly Tyr Phe Phe 705 710 715 720 Leu Gln Asn Ala Gly Met Leu Leu Gly Phe Gly Ile Met Leu Leu Ile 725 730 735 Ser Ile Phe Glu His Lys Ile Val Phe Arg Ile Asn Phe 740 745 <210> SEQ ID NO 103 <211> LENGTH: 519 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 103 Met Ile Pro Val Ser Leu Val Val Val Val Val Gly Gly Trp Thr Val 1 5 10 15 Val Tyr Leu Thr Asp Leu Val Leu Lys Ser Ser Val Tyr Phe Lys His 20 25 30 Ser Tyr Glu Asp Trp Leu Glu Asn Asn Gly Leu Ser Ile Ser Pro Phe 35 40 45 His Ile Arg Trp Gln Thr Ala Val Phe Asn Arg Ala Phe Tyr Ser Trp 50 55 60 Gly Arg Arg Lys Ala Arg Met Leu Tyr Gln Trp Phe Asn Phe Gly Met 65 70 75 80 Val Phe Gly Val Ile Ala Met Phe Ser Ser Phe Phe Leu Leu Gly Lys 85 90 95 Thr Leu Met Gln Thr Leu Ala Gln Met Met Ala Asp Ser Pro Ser Ser 100 105 110 Tyr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 115 120 125 Ser Ser Ser Ser Ser Ser Ser Ser Leu His Asn Glu Gln Val Leu Gln 130 135 140 Val Val Val Pro Gly Ile Asn Leu Pro Val Asn Gln Leu Thr Tyr Phe 145 150 155 160 Phe Thr Ala Val Leu Ile Ser Gly Val Val His Glu Ile Gly His Gly 165 170 175 Ile Ala Ala Ile Arg Glu Gln Val Arg Phe Asn Gly Phe Gly Ile Phe 180 185 190 Leu Phe Ile Ile Tyr Pro Gly Ala Phe Val Asp Leu Phe Thr Thr His 195 200 205 Leu Gln Leu Ile Ser Pro Val Gln Gln Leu Arg Ile Phe Cys Ala Gly 210 215 220 Ile Trp His Asn Phe Val Leu Ala Leu Leu Gly Ile Leu Ala Leu Val 225 230 235 240 Leu Leu Pro Val Ile Leu Leu Pro Phe Tyr Tyr Thr Gly Val Gly Val 245 250 255 Leu Ile Thr Glu Val Ala Glu Asp Ser Pro Ala Ile Gly Pro Arg Gly 260 265 270 Leu Phe Val Gly Asp Leu Val Thr His Leu Gln Asp Cys Pro Val Thr 275 280 285 Asn Val Gln Asp Trp Asn Glu Cys Leu Asp Thr Ile Ala Tyr Glu Pro 290 295 300 Gln Ile Gly Tyr Cys Ile Ser Ala Ser Thr Leu Gln Gln Leu Ser Phe 305 310 315 320 Pro Val Arg Ala Tyr Lys Arg Leu Asp Gly Ser Thr Glu Cys Cys Asn 325 330 335 Asn His Ser Leu Thr Asp Val Cys Phe Ser Tyr Arg Asn Asn Phe Asn 340 345 350 Lys Arg Leu His Thr Cys Leu Pro Ala Arg Lys Ala Val Glu Ala Thr 355 360 365 Gln Val Cys Arg Thr Asn Lys Asp Cys Lys Lys Ser Ser Ser Ser Ser 370 375 380 Phe Cys Ile Ile Pro Ser Leu Glu Thr His Thr Arg Leu Ile Lys Val 385 390 395 400 Lys His Pro Pro Gln Ile Asp Met Leu Tyr Val Gly His Pro Leu His 405 410 415 Leu His Tyr Thr Val Ser Ile Thr Ser Phe Ile Pro Arg Phe Asn Phe 420 425 430 Leu Ser Ile Asp Leu Pro Val Val Val Glu Thr Phe Val Lys Tyr Leu 435 440 445 Ile Ser Leu Ser Gly Ala Leu Ala Ile Val Asn Ala Val Pro Cys Phe 450 455 460 Ala Leu Asp Gly Gln Trp Ile Leu Asn Ser Phe Leu Asp Ala Thr Leu 465 470 475 480 Thr Ser Val Ile Gly Asp Asn Asp Val Lys Asp Leu Ile Gly Phe Phe 485 490 495 Ile Leu Leu Gly Gly Ser Val Leu Leu Ala Ala Asn Val Thr Leu Gly 500 505 510 Leu Trp Met Val Thr Ala Arg 515 <210> SEQ ID NO 104 <211> LENGTH: 274 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 104 Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 1 5 10 15 Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 20 25 30 Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 35 40 45 Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 50 55 60 Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 65 70 75 80 Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 85 90 95 Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 100 105 110 Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 115 120 125 Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 130 135 140 Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 145 150 155 160 Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 165 170 175 Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 180 185 190 Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 195 200 205 Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 210 215 220 Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 225 230 235 240 Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 245 250 255 Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 260 265 270 Gly Ser <210> SEQ ID NO 105 <211> LENGTH: 257 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 105 Met Ala Ala Asp Gly Val Asp Glu Arg Ser Pro Leu Leu Ser Ala Ser 1 5 10 15 His Ser Gly Asn Val Thr Pro Thr Ala Pro Pro Tyr Leu Gln Glu Ser 20 25 30 Ser Pro Arg Ala Glu Leu Pro Pro Pro Tyr Thr Ala Ile Ala Ser Pro 35 40 45 Asp Ala Ser Gly Ile Pro Val Ile Asn Cys Arg Val Cys Gln Ser Leu 50 55 60 Ile Asn Leu Asp Gly Lys Leu His Gln His Val Val Lys Cys Thr Val 65 70 75 80 Cys Asn Glu Ala Thr Pro Ile Lys Asn Pro Pro Thr Gly Lys Lys Tyr 85 90 95 Val Arg Cys Pro Cys Asn Cys Leu Leu Ile Cys Lys Asp Thr Ser Arg 100 105 110 Arg Ile Gly Cys Pro Arg Pro Asn Cys Arg Arg Ile Ile Asn Leu Gly 115 120 125 Pro Val Met Leu Ile Ser Glu Glu Gln Pro Ala Gln Pro Ala Leu Pro 130 135 140 Ile Gln Pro Glu Gly Thr Arg Val Val Cys Gly His Cys Gly Asn Thr 145 150 155 160 Phe Leu Trp Met Glu Leu Arg Phe Asn Thr Leu Ala Lys Cys Pro His 165 170 175 Cys Lys Lys Ile Ser Ser Val Gly Ser Ala Leu Pro Arg Arg Arg Cys 180 185 190 Cys Ala Tyr Ile Thr Ile Gly Met Ile Cys Ile Phe Ile Gly Val Gly 195 200 205 Leu Thr Val Gly Thr Pro Asp Phe Ala Arg Arg Phe Arg Ala Thr Tyr 210 215 220 Val Ser Trp Ala Ile Ala Tyr Leu Leu Gly Leu Ile Cys Leu Ile Arg 225 230 235 240 Ala Cys Tyr Trp Gly Ala Ile Arg Val Ser Tyr Pro Glu His Ser Phe 245 250 255 Ala <210> SEQ ID NO 106 <211> LENGTH: 619 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 106 Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn 1 5 10 15 Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp 20 25 30 Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr 35 40 45 Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly 50 55 60 Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu 65 70 75 80 Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu 85 90 95 Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr 100 105 110 Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly 115 120 125 Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp 130 135 140 Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr 145 150 155 160 Glu Ile Asp Met Lys Val Ile Gln Gln Arg Asn Glu Glu Cys Asp His 165 170 175 Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr 180 185 190 Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Glu Ser Arg Ile 195 200 205 Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp 210 215 220 Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu 225 230 235 240 Pro Gln Leu Gln Pro Gly Asn Cys Ser Leu Leu Ser Val Phe Ser Leu 245 250 255 Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile 260 265 270 Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu 275 280 285 Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Thr Glu Ile Ser Cys Leu 290 295 300 Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu 305 310 315 320 Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg 325 330 335 Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu 340 345 350 Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu 355 360 365 Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu 370 375 380 Asp Glu Lys Lys Lys Thr Asp Thr Leu Leu Tyr Ser Val Leu Pro Pro 385 390 395 400 Ser Val Ala Asn Glu Leu Arg His Lys Arg Pro Val Pro Ala Lys Arg 405 410 415 Tyr Asp Asn Val Thr Ile Leu Phe Ser Gly Ile Val Gly Phe Asn Ala 420 425 430 Phe Cys Ser Lys His Ala Ser Gly Glu Gly Ala Met Lys Ile Val Asn 435 440 445 Leu Leu Asn Asp Leu Tyr Thr Arg Phe Asp Thr Leu Thr Asp Ser Arg 450 455 460 Lys Asn Pro Phe Val Tyr Lys Val Glu Thr Val Gly Asp Lys Tyr Met 465 470 475 480 Thr Val Ser Gly Leu Pro Glu Pro Cys Ile His His Ala Arg Ser Ile 485 490 495 Cys His Leu Ala Leu Asp Met Met Glu Ile Ala Gly Gln Val Gln Val 500 505 510 Asp Gly Glu Ser Val Gln Ile Thr Ile Gly Ile His Thr Gly Glu Val 515 520 525 Val Thr Gly Val Ile Gly Gln Arg Met Pro Arg Tyr Cys Leu Phe Gly 530 535 540 Asn Thr Val Asn Leu Thr Ser Arg Thr Glu Thr Thr Gly Glu Lys Gly 545 550 555 560 Lys Ile Asn Val Ser Glu Tyr Thr Tyr Arg Cys Leu Met Ser Pro Glu 565 570 575 Asn Ser Asp Pro Gln Phe His Leu Glu His Arg Gly Pro Val Ser Met 580 585 590 Lys Gly Lys Lys Glu Pro Met Gln Val Trp Phe Leu Ser Arg Lys Asn 595 600 605 Thr Gly Thr Glu Glu Thr Lys Gln Asp Asp Asp 610 615 <210> SEQ ID NO 107 <211> LENGTH: 153 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 107 Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 1 5 10 15 Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 20 25 30 Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 35 40 45 Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 50 55 60 Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 65 70 75 80 Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 85 90 95 Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 100 105 110 Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 115 120 125 Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 130 135 140 Tyr Ala Val Ala Ile Lys Pro Cys Lys 145 150 <210> SEQ ID NO 108 <211> LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 108 Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 1 5 10 15 Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 20 25 30 Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 35 40 45 Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 50 55 60 Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 65 70 75 80 Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 85 90 95 Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 100 105 110 Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 115 120 125 Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 130 135 140 Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 145 150 155 160 Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 165 170 175 Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 180 185 190 Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 195 200 205 Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 210 215 220 Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 225 230 235 240 Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 245 250 <210> SEQ ID NO 109 <211> LENGTH: 518 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 109 Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 1 5 10 15 Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 20 25 30 Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 35 40 45 Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 50 55 60 Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 65 70 75 80 Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 85 90 95 Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 100 105 110 Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 115 120 125 Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 130 135 140 Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 145 150 155 160 Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 165 170 175 Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 180 185 190 Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 195 200 205 Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 210 215 220 Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 225 230 235 240 Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 245 250 255 Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 260 265 270 Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 275 280 285 Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 290 295 300 Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 305 310 315 320 Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 325 330 335 Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 340 345 350 Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 355 360 365 Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 370 375 380 Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 385 390 395 400 Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 405 410 415 Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 420 425 430 Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 435 440 445 Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 450 455 460 Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu Ser 465 470 475 480 Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln Gln 485 490 495 Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser Phe 500 505 510 Phe Tyr Leu Leu Tyr Ser 515 <210> SEQ ID NO 110 <211> LENGTH: 542 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 110 Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 1 5 10 15 Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 20 25 30 Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 35 40 45 Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 50 55 60 Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 65 70 75 80 Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 85 90 95 Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 100 105 110 Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 115 120 125 Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 130 135 140 Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 145 150 155 160 Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 165 170 175 Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 180 185 190 Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 195 200 205 Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 210 215 220 Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 225 230 235 240 Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 245 250 255 Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 260 265 270 Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 275 280 285 Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 290 295 300 Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 305 310 315 320 Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 325 330 335 Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 340 345 350 Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 355 360 365 Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 370 375 380 Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 385 390 395 400 Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 405 410 415 Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 420 425 430 Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 435 440 445 Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 450 455 460 Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 465 470 475 480 Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 485 490 495 Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 500 505 510 Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 515 520 525 Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 530 535 540 <210> SEQ ID NO 111 <211> LENGTH: 970 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 111 Met Ala Thr Cys Ile Gly Glu Lys Ile Glu Asp Phe Lys Val Gly Asn 1 5 10 15 Leu Leu Gly Lys Gly Ser Phe Ala Gly Val Tyr Arg Ala Glu Ser Ile 20 25 30 His Ser Gly Leu Glu Val Ala Ile Lys Met Ile Asp Lys Lys Ala Met 35 40 45 Tyr Lys Ala Gly Met Val Gln Arg Val Gln Asn Glu Val Lys Ile His 50 55 60 Cys Gln Leu Lys His Pro Ser Ile Leu Glu Leu Tyr Asn Tyr Phe Glu 65 70 75 80 Asp Ser Asn Tyr Val Tyr Leu Val Leu Glu Met Cys His Asn Gly Glu 85 90 95 Met Asn Arg Tyr Leu Lys Asn Arg Val Lys Pro Phe Ser Glu Asn Glu 100 105 110 Ala Arg His Phe Met His Gln Ile Ile Thr Gly Met Leu Tyr Leu His 115 120 125 Ser His Gly Ile Leu His Arg Asp Leu Thr Leu Ser Asn Leu Leu Leu 130 135 140 Thr Arg Asn Met Asn Ile Lys Ile Ala Asp Phe Gly Leu Ala Thr Gln 145 150 155 160 Leu Lys Met Pro His Glu Lys His Tyr Thr Leu Cys Gly Thr Pro Asn 165 170 175 Tyr Ile Ser Pro Glu Ile Ala Thr Arg Ser Ala His Gly Leu Glu Ser 180 185 190 Asp Val Trp Ser Leu Gly Cys Met Phe Tyr Thr Leu Leu Ile Gly Arg 195 200 205 Pro Pro Phe Asp Thr Asp Thr Val Lys Asn Thr Leu Asn Lys Val Val 210 215 220 Leu Ala Asp Tyr Glu Met Pro Thr Phe Leu Ser Ile Glu Ala Lys Asp 225 230 235 240 Leu Ile His Gln Leu Leu Arg Arg Asn Pro Ala Asp Arg Leu Ser Leu 245 250 255 Ser Ser Val Leu Asp His Pro Phe Met Ser Arg Asn Ser Ser Thr Lys 260 265 270 Ser Lys Asp Leu Gly Thr Val Glu Asp Ser Ile Asp Ser Gly His Ala 275 280 285 Thr Ile Ser Thr Ala Ile Thr Ala Ser Ser Ser Thr Ser Ile Ser Gly 290 295 300 Ser Leu Phe Asp Lys Arg Arg Leu Leu Ile Gly Gln Pro Leu Pro Asn 305 310 315 320 Lys Met Thr Val Phe Pro Lys Asn Lys Ser Ser Thr Asp Phe Ser Ser 325 330 335 Ser Gly Asp Gly Asn Ser Phe Tyr Thr Gln Trp Gly Asn Gln Glu Thr 340 345 350 Ser Asn Ser Gly Arg Gly Arg Val Ile Gln Asp Ala Glu Glu Arg Pro 355 360 365 His Ser Arg Tyr Leu Arg Arg Ala Tyr Ser Ser Asp Arg Ser Gly Thr 370 375 380 Ser Asn Arg Gln Ser Gln Ala Lys Thr Tyr Thr Met Glu Arg Cys His 385 390 395 400 Ser Ala Glu Met Leu Ser Val Ser Lys Arg Ser Gly Gly Gly Glu Asn 405 410 415 Glu Glu Arg Tyr Ser Pro Thr Asp Asn Asn Ala Asn Ile Phe Asn Phe 420 425 430 Phe Lys Glu Lys Thr Ser Ser Ser Ser Gly Ser Phe Glu Arg Pro Asp 435 440 445 Asn Asn Gln Ala Leu Ser Asn His Leu Cys Pro Gly Lys Thr Pro Phe 450 455 460 Pro Phe Ala Asp Pro Thr Pro Gln Thr Glu Thr Val Gln Gln Trp Phe 465 470 475 480 Gly Asn Leu Gln Ile Asn Ala His Leu Arg Lys Thr Thr Glu Tyr Asp 485 490 495 Ser Ile Ser Pro Asn Arg Asp Phe Gln Gly His Pro Asp Leu Gln Lys 500 505 510 Asp Thr Ser Lys Asn Ala Trp Thr Asp Thr Lys Val Lys Lys Asn Ser 515 520 525 Asp Ala Ser Asp Asn Ala His Ser Val Lys Gln Gln Asn Thr Met Lys 530 535 540 Tyr Met Thr Ala Leu His Ser Lys Pro Glu Ile Ile Gln Gln Glu Cys 545 550 555 560 Val Phe Gly Ser Asp Pro Leu Ser Glu Gln Ser Lys Thr Arg Gly Met 565 570 575 Glu Pro Pro Trp Gly Tyr Gln Asn Arg Thr Leu Arg Ser Ile Thr Ser 580 585 590 Pro Leu Val Ala His Arg Leu Lys Pro Ile Arg Gln Lys Thr Lys Lys 595 600 605 Ala Val Val Ser Ile Leu Asp Ser Glu Glu Val Cys Val Glu Leu Val 610 615 620 Lys Glu Tyr Ala Ser Gln Glu Tyr Val Lys Glu Val Leu Gln Ile Ser 625 630 635 640 Ser Asp Gly Asn Thr Ile Thr Ile Tyr Tyr Pro Asn Gly Gly Arg Gly 645 650 655 Phe Pro Leu Ala Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg 660 665 670 Tyr Ser Phe Asp Asn Leu Pro Glu Lys Tyr Trp Arg Lys Tyr Gln Tyr 675 680 685 Ala Ser Arg Phe Val Gln Leu Leu Arg Ser Lys Ser Pro Lys Ile Thr 690 695 700 Tyr Phe Thr Arg Tyr Ala Lys Cys Ile Leu Met Glu Asn Ser Pro Gly 705 710 715 720 Ala Asp Phe Glu Val Trp Phe Tyr Asp Gly Val Lys Ile His Lys Thr 725 730 735 Glu Asp Phe Ile Gln Val Ile Glu Lys Thr Gly Lys Ser Tyr Thr Leu 740 745 750 Lys Ser Glu Ser Glu Val Asn Ser Leu Lys Glu Glu Ile Lys Met Tyr 755 760 765 Met Asp His Ala Asn Glu Gly His Arg Ile Cys Leu Ala Leu Glu Ser 770 775 780 Ile Ile Ser Glu Glu Glu Arg Lys Thr Arg Ser Ala Pro Phe Phe Pro 785 790 795 800 Ile Ile Ile Gly Arg Lys Pro Gly Ser Thr Ser Ser Pro Lys Ala Leu 805 810 815 Ser Pro Pro Pro Ser Val Asp Ser Asn Tyr Pro Thr Arg Asp Arg Ala 820 825 830 Ser Phe Asn Arg Met Val Met His Ser Asp Ala Ser Pro Thr Gln Ala 835 840 845 Pro Ile Leu Asn Pro Ser Met Val Thr Asn Glu Gly Leu Gly Leu Thr 850 855 860 Thr Thr Ala Ser Gly Thr Asp Ile Ser Ser Asn Ser Leu Lys Asp Cys 865 870 875 880 Leu Pro Lys Ser Ala Gln Leu Leu Lys Ser Val Phe Val Lys Asn Val 885 890 895 Gly Trp Ala Thr Gln Leu Thr Ser Gly Ala Val Trp Val Gln Phe Asn 900 905 910 Asp Gly Ser Gln Leu Val Val Gln Ala Gly Val Ser Ser Ile Ser Tyr 915 920 925 Thr Ser Pro Asn Gly Gln Thr Thr Arg Tyr Gly Glu Asn Glu Lys Leu 930 935 940 Pro Asp Tyr Ile Lys Gln Lys Leu Gln Cys Leu Ser Ser Ile Leu Leu 945 950 955 960 Met Phe Ser Asn Pro Thr Pro Asn Phe His 965 970 <210> SEQ ID NO 112 <211> LENGTH: 345 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 112 Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 1 5 10 15 Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 20 25 30 Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 35 40 45 Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 50 55 60 His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 65 70 75 80 Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 85 90 95 Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 100 105 110 Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 115 120 125 Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 130 135 140 Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 145 150 155 160 Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 165 170 175 Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 180 185 190 Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 195 200 205 Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 210 215 220 Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 225 230 235 240 Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 245 250 255 Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 260 265 270 Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 275 280 285 His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 290 295 300 Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 305 310 315 320 His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 325 330 335 Cys Val Cys Arg Gly Ser Thr Gly Gly 340 345 <210> SEQ ID NO 113 <211> LENGTH: 309 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 113 tgctttcttt ttatctgttt tggtaggaat aagcttttgt tctcttttct gttttgcaag 60 aacttcatca tataatgttt ctttcatgaa aagccagaag aagaggaaaa ttactgtaat 120 aactattgaa ggaataagaa caataaaata tgctgactca taaaactcca tggtactttt 180 gtcaatgtga tcctataaaa ccctgtgcgg ccgggaaagg agaccgggaa gacgcggcgg 240 cgccggcact acagcccggg ccgcccgctc cgaggcgccg ccgccgccgc cgccgccgcc 300 gcagtcgct 309 <210> SEQ ID NO 114 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (221)..(221) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (324)..(324) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 114 gccaagtgat aaagccacaa ccttgtgttt gctttccctc ccaatcccag aactcaggac 60 tggagcccat gtggtttgca gttaaaggcc aaaagtcctg cacctatttt ataaaactat 120 gactgtgttt atcactgtgt tggggtcggt tccatttttg aggttccatc tttatgaaaa 180 gataacctgt cttctaacct gcttggatgg ctggtagtca natgtgaacg aacacctacc 240 gtgtgcctgg ccatgttcta tgttctaggc tgcagcaatc aacaagatgg gccatacaac 300 acccacccgg tgaagttcaa gtcnagtagc tgttagctta aggaaagagt attcccttat 360 cccactacac cttaaaatgt attgctgtcc 390 <210> SEQ ID NO 115 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 115 tttttttttc caacagcaga tagattcttt atgttcaaga cagcaaattc agatacaaaa 60 acccaccgcc atcgtccctc cctccctcct gctctgggcc agggatgggc ctggaaggag 120 agatgggagg tggggaggag gttgcggggt tcacagcaga ctcgtgtcaa atgcggaggt 180 aacaggctcc acagggaggg ggctcctctc aggaggggtg agggcattat tgcatttgct 240 ggggggaagg acaaccctct cccctgtatt ccctgcgtca ggaaactagg aaggtcatga 300 cccccaaaca gaacccaagg ccccagggag acagagggac cagtttggca gctgatggtg 360 gaaagtggtg gaggcggggg tggccgccaa tttggctgat cctc 404 <210> SEQ ID NO 116 <211> LENGTH: 499 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 116 tttttttttt ttcctggggt gagaatcaaa ttcctgtgag ggggcattta gctcactgga 60 gtattcacga attaaaactt caatagcccc tttaatcatc tgatctctcc tctttgtttc 120 ttcatccaag gcttcttcat cgtcattagt gacagtttct ggccttgcat tcccattaga 180 agctttcttc tttgctttcc attcatccag ctgtgccttt gtctttgcat caactttaac 240 gagtagcttt ttctctccaa tttgcaggtc atgtaataat ctgagtgcac ggagggtaga 300 ttctggctcc ttgtactcac agaatccgaa ggcttgaagc tttccggaag caccttgtac 360 tctcttccag ctcaaaacca aaccacattt agctaagagt tgtcttataa gcatgtctga 420 agctttctcg gaaatgttgc caacaaaaac agtggtagta ggaccacaat tttcatcatt 480 ttctttagcc tttaagcct 499 <210> SEQ ID NO 117 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (335)..(335) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 117 ttttgtggtc taaaataaac ttttaattgc acatttgtgt cttgggttat ctgtggggtg 60 agaaacctcc tcacttccaa tcccagctat ctgggtacaa tctggtgttg tggtctggct 120 gtcggcgagg ggtagaggtg ggtgcaggac tggcccccga gtctgcaccg acctcttcag 180 ggcagggagc tcagaccatg gtagtacttg cactgcttca gggcctcgct gaagccctca 240 cacagggaca ggtcactctg agtggtggaa cagtccagga actgcctgat ctcataggcg 300 cagggcccca tctgcagggg ctggggggca gcggnggtgg gggcctgctg gacagcaggc 360 tgggagggct ccgagctccc cccgctgaag gctccggtca gggcgctgcc catgacgtgt 420 cccacagccg agcccacggc tacccctgcg gccgtggtcg ccatctgagc catgagcccc 480 ggctggcccg aag 493 <210> SEQ ID NO 118 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (484)..(484) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 118 gtcaaattgt atccgttaag ggttttctaa cttttgctat cccccccgcg accaaaaaaa 60 gggggggttt ataatttaaa gaaaaggaaa agaggcgtgg gttggtagtt gtgtccttaa 120 catttaggaa tgacatagcc tctggagtct acaaactgaa gaaactttca tctgatcagc 180 cttggaaatc caaagttaaa gagcctatgt gtctcttgag gcgggggtta gaggattcaa 240 atttgggatg atgctcattg attcctgacc atagcagtga gaggccattt tttgtgcagg 300 aaatgtgctt aggactcagt cttgttttcg gattatccac cacagaaacc ctgagacaca 360 gagcagctta gaagtctcta cccaggcgta aatagagctc cctactccag acccatagcc 420 agtgagaagg cccatttttt tggtgcagga aatgtgctta gggactcagt ccttggtttt 480 cgantatcca ccacaggaaa ccctggagac tag 513 <210> SEQ ID NO 119 <211> LENGTH: 415 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 119 tgctttctct tctctttcat gatatccttg gtgtcctgca gcatcttctc cttccaaaga 60 tcaaagaagt atgaagggtc tgtgtagaat ttgagtgcct cttttccatc gtccctgtaa 120 ggggtaagat tgttgagagg gggaggagta tcacaggtat tgtatgtttc taagacaggc 180 actgggagag agtttctgtc aaaaagcttc tggtcttgaa tggtggaact tctgaaggct 240 tttcgggtgt tgattccttg cagtgacact tcttcttcct tgggatccag ctgagtgact 300 ttaacctgta gtcggtcgac cctctcagca agggagctta cccgaggagc aaaggtattt 360 tcctgagtag aggactcccg aagaatgtct ctgcatattt actcaggctg ccgac 415 <210> SEQ ID NO 120 <211> LENGTH: 426 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 120 ttatgatttg gatgttttta aattattaat ttattttcaa atcatactca gtttgagttc 60 aaatagttca aaaatcaata taatgcttca ggatgcttcc agctattgaa acaacccaat 120 taaaaaatat acaactcaca ctttatttta gttaaattca taatgtaggt aatattaaaa 180 attattataa acatttaata atgctttata atttgctatt atagtacacc actacagaca 240 cataaaaagt tgacttatct aattaaaaca ttttcccttc ctatgtttct aattctgaaa 300 actataaaaa tattaaagtc atgttacata tttttcaaaa ataaaactgc catatcccat 360 tgccaacttt acatgaaaaa ggtatatgtt ctggtatatt aggaagttaa tgatgaaaaa 420 tatagg 426 <210> SEQ ID NO 121 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 121 tttttttttc tcttttaaaa acttttatta cgcattgcta aataacattg catgatgtat 60 tgcacacatc atgtggtaaa cagcactcca cagtaatcca tacaatagct cgtacaatga 120 ccatcaaaat agtttgaaaa ccgttatagt tttcatccga gtgagtgtct ttatattctt 180 ccatgcaatc tgatttcata attaagatta ctcttccatt ctacaacaac caaccgaaaa 240 taatttttta taaaagccca accacaacaa aaggtcattg ggacattacg aaaagtcgga 300 aattagactc caaaatatca caaggtgtcc gtcttttgaa agacttgtcc ctaaaatttg 360 tgtgatctga cacttgggtt gcttttaccg ccagcagcat gtgacactgt acttactgag 420 aaggaacagt acattgacat atcg 444 <210> SEQ ID NO 122 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (419)..(419) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (431)..(431) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (446)..(446) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (467)..(467) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 122 caattaaggg tgtacaaatt ataataatgc atctctatct tcatactttg aatggcaaac 60 gctatttatg cataaatatt ttcattttaa gtaatatatg aagtgtaaat actcgatata 120 taagtataga ttttaaagat atgggacttt attttcacat aagtcaatag atgtttctct 180 agaacaaaat atttagtaaa gctttataaa ttatattaaa aggaagcggg gaacatgtat 240 tttttaacat agaacagaag tgacttcatt ctttttagac atcagaaatg ttaaagttga 300 ttcccaatat ttgttgtact tttttgtagc aaatgttaaa aatcaccgag ttaccatgta 360 tagaatgtgg actgtcatgt tgatatcatt ggtacagtgg ataagcccat ttttaaccng 420 tatacatttc nccaatttaa ttaacngggg tgaataattt ggtttcnttt taga 474 <210> SEQ ID NO 123 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (419)..(419) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (431)..(431) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (446)..(446) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (467)..(467) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 123 caattaaggg tgtacaaatt ataataatgc atctctatct tcatactttg aatggcaaac 60 gctatttatg cataaatatt ttcattttaa gtaatatatg aagtgtaaat actcgatata 120 taagtataga ttttaaagat atgggacttt attttcacat aagtcaatag atgtttctct 180 agaacaaaat atttagtaaa gctttataaa ttatattaaa aggaagcggg gaacatgtat 240 tttttaacat agaacagaag tgacttcatt ctttttagac atcagaaatg ttaaagttga 300 ttcccaatat ttgttgtact tttttgtagc aaatgttaaa aatcaccgag ttaccatgta 360 tagaatgtgg actgtcatgt tgatatcatt ggtacagtgg ataagcccat ttttaaccng 420 tatacatttc nccaatttaa ttaacngggg tgaataattt ggtttcnttt taga 474

1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 123 <210> SEQ ID NO 1 <211> LENGTH: 3118 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 1 gcgcgcccgc cagccaggct ctccgcgccc gccgcccgcg ccgcgctggc ccgggctctc 60 ccgcccgcgc ttcatggctg cacacgagtg ggactggttc caacgcgagg agctcatcgg 120 gcagattagc gacatccgag tgcagaacct gcaagttgag agggaaaatg tgcagaagag 180 gacctttaca cgatggataa atctacatct agaaaagtgc aacccacctc tagaagttaa 240 agatttattc gtcgatatac aagatggcaa aatcctaatg gctttgttag aagtcctgtc 300 tgggcggaat ctgctgcacg aatacaaatc ctcgtcgcat cgtatttttc ggttgaacaa 360 catagcgaaa gcacttaagt ttttggaaga tagcaatgta aaactggtta gcattgatgc 420 agcagaaata gcagatggca acccttcttt ggttcttggg ctgatatgga acataatcct 480 cttcttccag attaaggagc tcacaggcaa cctcagcaga aactctccat cttccagctt 540 gtcccctggc tcagggggca cagactcaga ctcatccttc ccacccacac ccactgcaga 600 gaggagcgtg gcaatatcgg tgaaagacca gaggaaggct atcaaggccc tgttggcgtg 660 ggtgcagagg aaaacgagaa agtatggcgt ggcggtgcag gactttgcgg gcagttggag 720 gagtgggctg gctttcctgg cggtgatcaa ggccattgac cccagcctgg tggacatgaa 780 acaggccctg gaaaattcca cacgagaaaa tctagagaag gctttcagca tcgcacagga 840 tgccctgcac atccccaggc tcctggagcc agaagacatc atggttgaca caccagacga 900 gcagtctatc atgacttacg tggcacagtt tctagaacgt tttccggagt tggaagccga 960 agatattttc gattcagata aagaagttcc tatcgaatcc acttttgttc gcatcaaaga 1020 aactccttct gaacaggaga gcaaagtctt cgttctgact gaaaatgggg agcgtaccta 1080 cactgttaac catgaaacca gccacccacc accctccaaa gtctttgtct gtgacaagcc 1140 cgagagcatg aaggaattcc gcctggatgg tgtttccagc catgcgctgt cagacagctc 1200 caccgagttc atgcaccaga ttattgacca ggtcctgcaa gggggcccag gtaagaccag 1260 cgacatcagt gagccatctc cagaatcctc cattttatca tccagaaagg agaacgggag 1320 gtccaactct ttgccgatca agaaaacagt tcactttgag gctgacacct acaaggatcc 1380 tttctgcagt aagaacctgt ccctttgctt tgaagggagc ccaagagtgg caaaggaatc 1440 attgaggcag gatggacatg tcttggcagt tgaggttgct gaggaaaagg aacagaaaca 1500 ggaatcctcg aagattccag aatcctcctc tgacaaggtc gctggtgaca tttttttggt 1560 ggagggcaca aacaataatt ctcagtcttc ttcctgtaat ggtgctttag agagtacagc 1620 ccgccacgat gaagaaagtc actctctttc acccccagga gaaaatactg tgatggccga 1680 ttccttccag atcaaggtta acctgatgac tgtagaagct ttagaggagg gagactattt 1740 tgaagccatc ccattaaaag cctcaaaatt taacagcgac ctaatagatt ttgcttctac 1800 cagccaggct ttcaacaaag ttccttcacc tcatgagaca aaacctgacg aggatgctga 1860 ggcttttgag aatcatgctg aaaaactagg taaaaggagt attaaatctg ctcacaaaaa 1920 gaaggattcg ccagagcctc aagttaagat ggacaaacat gaacctcatc aggactccgg 1980 agaagaagct gaaggctgtc cttcagcccc agaagagaca ccagtggata aaaagccaga 2040 ggtgcatgaa aaggccaaga gaaagtccac ccgtcctcat tatgaggaag agggagaaga 2100 cgatgacctc cagggtgtgg gcgaggaatt atcttccagc cccccaagca gctgtgtcag 2160 cttggagacc cttgggagtc acagcgaaga aggcctggat ttcaagccct ccccacccct 2220 ctcaaaggtt tccgtcattc cccacgacct cttctatttc ccacactatg aggttcccct 2280 ggctgcagtt ttggaggctt atgtagaaga cccggaggat ctaaaaaatg aagaaatgga 2340 tctcgaagag ccagagggct atatgccaga cctggactcc agggaggagg aggccgatgg 2400 ctctcagagc agctccagtt cctcggtgcc aggagagagc ctccccagtg ccagcgacca 2460 ggtgctgtat ctcagcaggg gtggtgtggg taccacacca gcctcagaac ccgctccact 2520 ggccccccat gaggaccacc agcaaaggga gaccaaagag aatgacccca tggacagcca 2580 tcagtcccag gaatccccaa acctggaaaa catagcaaac cccctagaag aaaatgtaac 2640 gaaagaatca atcagtagta aaaaaaagga aaaaaggaaa catgtggacc acgtagaaag 2700 ttcactattt gtagcaccag gaagtgttca atcctcagat gacctagaag aagacagtag 2760 cgactacagc attccttcca ggactagtca cagtgactcc agcatttacc ttcgacgaca 2820 tactcatagg tcttcggaat cggatcattt tagctatgtt cagttgagga acgcagcaga 2880 tctggatgac agaagaaacc gaatattaac caggaaggcc aacagctcag gagaagccat 2940 gtcactgggg agccacagcc cgcagagtga ctccctgaca cagcttgtcc agcagccgga 3000 tatgatgtat tttattctct tcctgtggct cctggtgtac tgcttgctgc tcttcccaca 3060 actggatgtt agcaggctct gatacgtgtg tctggataat aaaaaagaca ggaccctg 3118 <210> SEQ ID NO 2 <211> LENGTH: 930 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 gcgagccgga gcgacggcgg ggctggggcc ggagccgagc cggggtcggg cagcagcagg 60 gaccccccag aggcggggcc tgtgggaccg ctatgggcgt ggagatcgag accatctccc 120 ccggagacgg aaggacattc cccaagaagg gccaaacgtg tgtggtgcac tacacaggaa 180 tgctccaaaa tgggaagaag tttgattcat ccagagacag aaacaaacct ttcaagttca 240 gaattggcaa acaggaagtc atcaaaggtt ttgaagaggg tgcagcccag atgagcttgg 300 ggcagagggc gaagctgacc tgcacccctg atgtggcata tggagccacg ggccaccccg 360 gtgtcatccc tcccaatgcc accctcatct ttgacgtgga gctgctcaac ttagagtgaa 420 ggcaggaagg aactcaaggt ggtggctgga gatggctgct gctcaccctc ctagcctgct 480 ctgccactgg gacggctcct gcttttgggg ctcttgatca gtgtgctaac ctcactgcct 540 catggcatca tccattctct ctgcccaagt tgctctgtat gtgttcgtca gtgttcatgc 600 gaattcttgc ttgaggaaac ttcggttgca gattgaagca tttcaggttg tgcattttgt 660 gtgatgcatg tagtagcctt tcctgatgac agaacacaga tctcttgttc gcacaatcta 720 cactgcctta ccttcactta aaccacacac acaaggtgct cagacatgaa atgtacatgg 780 cgtaccgtac acagagggac ttgagccagt tacctttgct gtcactttct ctcttataaa 840 ttctgttagc tgctcactta aacaatgtcc tctttgagaa aatgtaaaat aaaggctctg 900 tgcttgacaa aaaaaaaaaa aaaaaaaaaa 930 <210> SEQ ID NO 3 <211> LENGTH: 972 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 3 gcgagccgga gcgacggcgg ggctggggcc ggagccgagc cggggtcggg cagcagcagg 60 gaccccccag aggcggggcc tgtgggaccg ctatgggcgt ggagatcgag accatctccc 120 ccggagacgg aaggacattc cccaagaagg gccaaacgtg tgtggtgcac tacacaggaa 180 tgctccaaaa tgggaagaag tttgattcat ccagagacag aaacaaacct ttcaagttca 240 gaattggcaa acaggaagtc atcaaaggtt ttgaagaggg tgcagcccag ctgggtcctc 300 tttctcctct ccccatctgc ccccatccct gctagatgag cttggggcag agggcgaagc 360 tgacctgcac ccctgatgtg gcatatggag ccacgggcca ccccggtgtc atccctccca 420 atgccaccct catctttgac gtggagctgc tcaacttaga gtgaaggcag gaaggaactc 480 aaggtggctg gagatggctg ctgctcaccc tcctagcctg ctctgccact gggacggctc 540 ctgcttttgg ggctcttgat cagtgtgcta acctcactgc ctcatggcat catccattct 600 ctctgcccaa gttgctctgt atgtgttcgt cagtgttcat gcgaattctt gcttgaggaa 660 acttcggttg cagattgaag catttcaggt tgtgcatttt gtgtgatgca tgtagtagcc 720 tttcctgatg acagaacaca gatctcttgt tcgcacaatc tacactgcct taccttcact 780 taaaccacac acacaaggtg ctcagacatg aaatgtacat ggcgtaccgt acacagaggg 840 acttgagcca gttacctttg ctgtcacttt ctctcttata aattctgtta gctgctcact 900 taaacaatgt cctctttgag aaaatgtaaa ataaaggctc tgtgcttgac aaaaaaaaaa 960 aaaaaaaaaa aa 972 <210> SEQ ID NO 4 <211> LENGTH: 4816 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 cgtcttcccg gtctcctttc ccggccgcac agggtagatt ttcgttccgt cacccaggct 60 ggagtgcagt ggtgtgacct tggcttgctg caaccctttg cctcctgggt tcaagtgatt 120 ctcattgcct cagcctccta agtagctggg attacaggtt ttataggatc acattgacaa 180 aagtaccatg gagttttatg agtcagcata ttttattgtt cttattcctt caatagttat 240 tacagtaatt ttcctcttct tctggctttt catgaaagaa acattatatg atgaagttct 300 tgcaaaacag aaaagagaac aaaagcttat tcctaccaaa acagataaaa agaaagcaga 360 aaagaaaaag aataaaaaga aagaaatcca gaatggaaac ctccatgaat ccgactctga 420 gagtgtacct cgagacttta aattatcaga tgctttggca gtagaagatg atcaagttgc 480 acctgttcca ttgaatgtcg ttgaaacttc aagtagtgtt agggaaagaa aaaagaagga 540 aaagaaacaa aagcctgtgc ttgaagagca ggtcatcaaa gaaagtgacg catcaaagat 600 tcctggcaaa aaagtagaac ctgtcccagt tactaaacag cccacccctc cctctgaagc 660 agctgcctcg aagaagaaac cagggcagaa gaagtctaaa aatggaagcg atgaccagga 720 taaaaaggtg gaaactctca tggtaccatc aaaaaggcaa gaagcattgc ccctccacca 780 agagactaaa caagaaagtg gatcagggaa gaagaaagct tcatcaaaga aacaaaagac 840 agaaaatgtc ttcgtagatg aaccccttat tcatgcaact acttatattc ctttgatgga 900 taatgctgac tcaagtcctg tggtagataa gagagaggtt attgatttgc ttaaacctga 960 ccaagtagaa gggatccaga aatctgggac taaaaaactg aagaccgaaa ctgacaaaga 1020 aaatgctgaa gtgaagttta aagattttct tctgtccttg aagactatga tgttttctga 1080 agatgaggct ctttgtgttg tagacttgct aaaggagaag tctggtgtaa tacaagatgc 1140 tttaaagaag tcaagtaagg gagaattgac tacgcttata catcagcttc aagaaaagga 1200 caagttactc gctgctgtga aggaagatgc tgctgctaca aaggatcggt gtaagcagtt 1260 aacccaggaa atgatgacag agaaagaaag aagcaatgtg gttataacaa ggatgaaaga 1320

tcgaattgga acattagaaa aggaacataa tgtatttcaa aacaaaatac atgtcagtta 1380 tcaagagact caacagatgc agatgaagtt tcagcaagtt cgtgagcaga tggaggcaga 1440 gatagctcac ttgaagcagg aaaatggtat actgagagat gcagtcagca acactacaaa 1500 tcaactggaa agcaagcagt ctgcagaact aaataaacta cgccaggatt atgctaggtt 1560 ggtgaatgag ctgactgaga aaacaggaaa gctacagcaa gaggaagtcc aaaagaagaa 1620 tgctgagcaa gcagctactc agttgaaggt tcaactacaa gaagctgaga gaaggtggga 1680 agaagttcag agctacatca ggaagagaac agcggaacat gaggcagcac agcaagattt 1740 acagagtaaa tttgtggcca aagaaaatga agtacagagt ctgcatagta agcttacaga 1800 taccttggta tcaaaacaac agttggagca aagactaatg cagttaatgg aatcagagca 1860 gaaaagggtg aacaaagaag agtctctaca aatgcaggtt caggatattt tggagcagaa 1920 tgaggctttg aaagctcaaa ttcagcagtt ccattcccag atagcagccc agacctccgc 1980 ttcagttcta gcagaagaat tacataaagt gattgcagaa aaggataagc agataaaaca 2040 gactgaagat tctttagcaa gtgaacgtga tcgtttaaca agtaaagaag aggaacttaa 2100 ggatatacag aatatgaatt tcttattaaa agctgaagtg cagaaattac aggccctggc 2160 aaatgagcag gctgctgctg cacatgaatt ggagaagatg caacaaagtg tttatgttaa 2220 agatgataaa ataagattgc tggaagagca actacaacat gaaatttcaa acaaaatgga 2280 agaatttaag attctaaatg accaaaacaa agcattaaaa tcagaagttc agaagctaca 2340 gactcttgtt tctgaacagc ctaataagga tgttgtggaa caaatggaaa aatgcattca 2400 agaaaaagat gagaagttaa agactgtgga agaattactt gaaactggac ttattcaggt 2460 ggcaactaaa gaagaggagc tgaatgcaat aagaacagaa aattcatctc tgacaaaaga 2520 agttcaagac ttaaaagcta agcaaaatga tcaggtttct tttgcctctc tagttgaaga 2580 acttaagaaa gtgatccatg agaaagatgg aaagatcaag tctgtagaag agcttctgga 2640 ggcagaactt ctcaaagttg ctaacaagga gaaaactgtt caggatttga aacaggaaat 2700 aaaggctcta aaagaagaaa taggaaatgt ccagcttgaa aaggctcaac agttatctat 2760 cacttccaaa gttcaggagc ttcagaactt attaaaagga aaagaggaac agatgaatac 2820 catgaaggct gttttggaag agaaagagaa agacctagcc aatacaggga agtggttaca 2880 ggatcttcaa gaagaaaatg aatctttaaa agcacatgtt caggaagtag cacaacataa 2940 cttgaaagag gcctcttctg catcacagtt tgaagaactt gagattgtgt tgaaagaaaa 3000 ggaaaatgaa ttgaagaggt tagaagccat gctaaaagag agggagagtg atctttctag 3060 caaaacacag ctgttacagg atgtacaaga tgaaaacaaa ttgtttaagt cccaaattga 3120 gcagcttaaa caacaaaact accaacaggc atcttctttt ccccctcatg aagaattatt 3180 aaaagtaatt tcagaaagag agaaagaaat aagtggtctc tggaatgagt tagattcttt 3240 gaaggatgca gttgaacacc agaggaagaa aaacaatgac cttcgggaga aaaactggga 3300 agcaatggaa gcattggcat caactgaaaa aatgctgcag gacaaagtga acaagacttc 3360 caaggaaagg cagcaacagg tggaagctgt tgagttggag gctaaagaag ttctcaaaaa 3420 attatttcca aaggtgtctg tcccttctaa tttgagttat ggtgaatggt tgcatggatt 3480 tgaaaaaaag gcaaaagaat gtatggctgg aacttcaggg tcagaggagg ttaaggttct 3540 agagcacaag ttgaaagaag ctgatgaaat gcacacattg ttacagctag agtgtgaaaa 3600 atacaaatcc gtccttgcag aaacagaagg aattttacag aagctacaga gaagtgttga 3660 gcaagaagaa aataaatgga aagttaaggt cgatgaatca cacaagacta ttaaacagat 3720 gcagtcatca tttacatctt cagaacaaga gctagagcga ttaagaagcg aaaataagga 3780 tattgaaaat ctgagaagag aacgagaaca tttggaaatg gaactagaaa aggcagagat 3840 ggaacgatct acctatgtta cagaagtcag agagctgaaa gatctgttga ctgaattgca 3900 gaaaaaactt gatgattcat attctgaagc agtaagacag aatgaagagc taaatttgtt 3960 gaaggcacag ttaaatgaaa cactcacaaa acttagaact gaacaaaatg aaagacagaa 4020 ggtagctggt gatttgcata aggctcaaca gtcactggag cttatccagt caaaaatagt 4080 aaaagctgct ggagacacta ctgttattga aaatagtgat gtttccccag aaacggagtc 4140 ttctgagaag gagacaatgt ctgtaagtct aaatcagact gtaacacagt tacagcagtt 4200 gcttcaggcg gtaaaccaac agctcacaaa ggagaaagag cactaccagg tgttagagtg 4260 atcatcctct ggcctacctt gacacatgct ctccttcaaa atgctaattc agagtgaagt 4320 aattgggaaa ctgttcattt gaggataaaa aaggcattgt attatatttt gccaaattaa 4380 agccttattt atgttttcac cctttctact ttgtcagaaa cactgaacag agttttgtct 4440 tttctaatcc ttgttagact actgatttaa agaaggaaaa aaaaaagcca actctgtaga 4500 caccttcaga gtttagtttt ataataaaaa ctgtttgaat aattagacct ttacattcct 4560 gaagataaac atgtaatctt ttatcttatt ttgctcaata aaattgttca gaagatcaaa 4620 gtggtaaaga caatgtaaaa tttaacattt taatactgat gttgtacact gttttactta 4680 acattttggg aagtaactgc ctctgacttc aactcaagaa aacacttttt tgttgctaat 4740 gtaatcggtt tttgtaatgg cgtcagcaaa taaaaggatg cttattattc aaaaaaaaaa 4800 aaaaaaaaaa aaaaaa 4816 <210> SEQ ID NO 5 <211> LENGTH: 4737 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5 gtcccagcgt cgctccggac gctgccaacc tgttctccac cgtcgctcga cttccacctc 60 taagactccc acgaaactca ggttgaataa ttcatcaaat tacacaactg aactcaagac 120 atggctgccc agtgtgtcac aaaggtggcg ctgaatgttt cctgtgccaa tcttttggat 180 aaagatatag ggtcaaagtc agacccttta tgtgtgttgt ttttgaatac aagtggtcaa 240 cagtggtatg aggttgagcg cacagaaagg attaagaatt gcttgaatcc ccaattttcc 300 aagacattta ttattgatta ctactttgaa gtggttcaga aattgaaatt tggggtttat 360 gacatcgaca acaaaactat tgagctgagt gatgatgact tcttagggga atgtgaatgt 420 acccttggac aaattgtttc cagcaagaag ctaactcgac cactggtgat gaaaactggc 480 agacctgcag gaaaagggag cattacgatt tcagctgaag aaataaaaga taatagagtg 540 gtcttgtttg aaatggaagc cagaaaactg gataataagg atctatttgg aaagtcagac 600 ccatacctgg aattccacaa gcagacatct gatggaaact ggctaatggt tcatcggaca 660 gaggttgtta aaaacaactt gaatcctgtt tggaggcctt tcaagatctc tcttaactca 720 ctgtgttacg gagatatgga caaaaccatt aaggtggagt gttatgatta tgacaatgat 780 gggtcacatg atctcattgg aacatttcag accaccatga caaaactgaa agaagcctcc 840 agaagctcac ctgttgaatt tgaatgcata aatgagaaaa aaaggcaaaa gaaaaaaagc 900 tacaagaatt caggtgttat cagtgtgaaa cagtgtgaga ttacagtaga atgcacattc 960 cttgactata taatgggagg atgtcagctg aattttactg tgggagtgga cttcactggc 1020 tccaatggtg acccaaggtc tccagactcc cttcattaca tcagccccaa tggcgttaat 1080 gagtatttga ctgctctctg gtctgtggga ctggtcattc aagattatga tgctgataag 1140 atgtttccag cttttggttt tggcgctcag atacctcctc agtggcaggt atcacatgaa 1200 tttccaatga acttcaaccc atccaatccc tactgcaatg gaatccaagg cattgtagag 1260 gcgtatcggt cttgtcttcc tcagataaaa ctctatggac caactaattt ttctccaatc 1320 ataaatcacg tggccaggtt tgctgctgca gccacgcaac agcagacagc ttctcaatat 1380 tttgtgcttt tgattattac tgatggtgtg atcacagacc ttgatgaaac cagacaagct 1440 atagttaatg cctccaggct gcctatgtcc atcataattg ttggagttgg aggtgctgac 1500 ttcagcgcca tggagtttct ggatggtgat ggtggaagtc tccgctcccc attgggcgaa 1560 gtggccatca gagatattgt ccagtttgtg cctttcagac agttccagaa tgctccaaaa 1620 gaagcacttg ctcagtgtgt cttggcagag attccccagc aggtggtggg ctacttcaat 1680 acatacaaac tccttcctcc caagaaccca gccacgaaac aacagaagca gtgaccactt 1740 caacagaatt cttttgtgtt atgtggagca atgccatctc tcaccccaaa tcgtgtatct 1800 gtcattctac gtacttttta cccccagcat ttatgatgta aatctctttc tctatggatt 1860 atatctgttt aaagcattct ttctaggtta ttttgggggg acagtgccaa gtccatcttt 1920 gcccagtcaa ttcagtgatt gatagcaatt tacattaatt gcagtaaagc tctttggatt 1980 agaaattagt gtggggaaag cttattctgt tgttgttttt gtttactttc atatgatgaa 2040 aatgctgtgt ttaagtgttt gtcaatagga agaatggaaa actgttggga tgatgtggtt 2100 tgcaggttgc tgtgcctgat tcacagtgta tgttgtataa gccaatgtcc atacctgatt 2160 atgagagctt cttaaattat atgatatcaa atttgttcct gtaactctgt atacagtgct 2220 tttctgcaag gtaaaaataa cctgtctatg catctgattt ttgctacagt ttagacactg 2280 tggtttacaa aacagcatgc actcaacttg ggactttatg aaaagtactg aatgagcagg 2340 aaaaggcgca tactcagttt tttaaatgta caatcaacaa gtaaaaataa cctcatgtaa 2400 gtaagccatt tttatttgcc tttctagata ttttatttta ttgtggaaaa ctgtaaacat 2460 ggtcagattt ggcttttttt ttcattaact gagcaagact ttcaggatat tgtagatgca 2520 cagatggtag gttgtcctga attctacatt attagattac tttaattgag atttgttaaa 2580 acggttagga ctgttttgtc caggaaagat aagaggacca aacatataag gtgaaattca 2640 gaattccgtt tccttctaac taatgaaaaa ctgcttacta aaaaaaaatt ttatactttc 2700 cttgctaagg tcccatatat tgatttgtac agatccactt agtcattttc tccttttttt 2760 aagaaccatt ttcatctgat ttttaaactc acgataccag ttatctgtta atcaaaattg 2820 cattttacaa tttaataatg tgatatttcc tatgtctaca gcatacctta ttaggtataa 2880 aacctactgc aacttagaaa aaggaaagaa aaaagaagac ttttccaact gctgcattaa 2940 gatagggtgg attttatgtg cttttttttt ttaagagttg aatttctttt cctgactttt 3000 accttttaca gcgtattact tagtgaacat tacattttca gaatagatcc taatatttta 3060 ttgagggcct atgtgctaaa aactatgcat atctatatat tggccaatta tctttaataa 3120 tttacctttt gaaattgcat gtttatcata tatccttaag tggacacata cagtgccatg 3180 ttgatgtgcc tctcagtttt attgaaaagc tgccccacag cccatgtctc ttgttctctg 3240 caatgcctca agggagtgag ctctcaacca cagatagctg tggcttctca gaagcagctc 3300 attgccaagg ccaggctgag aggggacctg cttgctgtgg tggttgccta gcccagatga 3360 gcatttacct accaccttcc cacttggcta gctgtccttt ggatatgtgc tgttaactgg 3420 ggaaggcatc taactagtag cctgctactc catagtatgg ctcaatagat gacacatcat 3480 tttgacatta tcaataggag aaaagaaaac taacccttct tctgattgtt tggagccata 3540 gttgtctcag atgttctaat tctctttgta tgcttggaaa cagcatagat atgttgctgt 3600 ggttttcaga attttctctt ttaatcacaa gaagcctttt aaaaaatgac ttacacatat 3660 tctcaatgta cagtaaaaca gacagaagtg agcttatctg tttgatgctg tggcagggtc 3720

ccagtcactg ggcatatcct ccttctcctt aaccagcttc tcagcagccc ctgagtcacc 3780 tgcacaaggt gcttgggaac tgctggttat gagcattcct ggttttcttc agccaaataa 3840 caggtaatca ctgtcaattg gatttggtct tcattatttt atattctgat tttatcagaa 3900 ttattctatt ttaaaattgt tttaaaattt aaaaacattt aattcatgat catgttcatc 3960 agtagatgct attattcata agaactgtga ttccagcaaa ctagggtaat tggtgccttt 4020 ttacagtttt gaataaaagc atttacaatt tctaaattat cagttttcac agtttcagca 4080 ctcaacctca tcatacgctg atttaatatt gttttacatt aaaatagtcc ttttccctgt 4140 tgtgccacca ttcatttaag tgctgtttgt tcttaaaatg catttaaaga aaaattaccc 4200 atattgactt tcacacctca tataatcaga tctattacaa atatatatcg gagtgacggt 4260 gcccaggata gatgtaatat ttcttacaga tgctggcaca gaggaaataa tataccagct 4320 aatctagtca cctaaccttg tggttagaat tgcaatttta agaccagaaa aatttgaagt 4380 ctgatcagag atttacaact gttcattata gtggtgcctt aggcaatctt tccaaagtaa 4440 attcagggcc ccattgctac ttatgccata tttggacata cttttttttt cttcaatttt 4500 gtaaacttcc tggaaagctg tcttcactaa gtatccccta gtctctatat atgtggttag 4560 tagtcatgga aatgacacat aaagtacgcc agaagtttga tggaacgtgt tagaaactgt 4620 tttgtgcttt tatggatgtc atacttgaca atacatgtgt aagttactaa tatatgaatt 4680 gatgctaaat atatcttaca tttgaattcc ttttggataa agttatttct tgatgtg 4737 <210> SEQ ID NO 6 <211> LENGTH: 1924 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 ccccgccttc acccactgcc tctgcctccc tggggcagag ctgtttccca gacgggtggg 60 gcggggccca actgtcccag ctccttcagc cctttctgtc cctcccagtg aggccagctg 120 cggtgaagag ggtgctctct tgcctggcgt tccctctgca cggctgcccc ctcccaccct 180 gcccactaag ccagacccac tgtcgccatt cccacttctg gtcctgccac ctcctgagct 240 gccttcccgc ctggtctggg tagagtcatg gcctcgagca caggtgaccg gagccaggcg 300 gtgaggcatg gactgagggc gaaggtgctg acgctggacg gcatgaaccc gcgtgtgcgg 360 agagtggagt acgcagtgcg tggccccata gtgcagcgag ccttggagct ggagcaggag 420 ctgcgccagg gtgtgaagaa gcctttcacc gaggtcatcc gtgccaacat cggggacgca 480 caggctatgg ggcagaggcc catcaccttc ctgcgccagg tcttggccct ctgtgttaac 540 cctgatcttc tgagcagccc caacttccct gacgatgcca agaaaagggc ggagcgcatc 600 ttgcaggcgt gtgggggcca cagtctgggg gcctacagcg tcagctccgg catccagctg 660 atccgggagg acgtggcgcg gtacattgag aggcgtgacg gaggcatccc tgcggacccc 720 aacaacgtct tcctgtccac aggggccagc gatgccatcg tgacggtgct gaagctgctg 780 gtggccggcg agggccacac acgcacgggt gtgctcatcc ccatccccca gtacccactc 840 tactcggcca cgctggcaga gctgggcgca gtgcaggtgg attactacct ggacgaggag 900 cgtgcctggg cgctggacgt ggccgagctt caccgtgcac tgggccaggc gcgtgaccac 960 tgccgccctc gtgcgctctg tgtcatcaac cctggcaacc ccaccgggca ggtgcagacc 1020 cgcgagtgca tcgaggccgt gatccgcttc gccttcgaag agcggctctt tctgctggcg 1080 gacgaggtgt accaggacaa cgtgtacgcc gcgggttcgc agttccactc attcaagaag 1140 gtgctcatgg agatggggcc gccctacgcc gggcagcagg agcttgcctc cttccactcc 1200 acctccaagg gctacatggg cgagtgcggg ttccgcggcg gctatgtgga ggtggtgaac 1260 atggacgctg cagtgcagca gcagatgctg aagctgatga gtgtgcggct gtgcccgccg 1320 gtgccaggac aggccctgct ggacctggtg gtcagcccgc ccgcgcccac cgacccctcc 1380 tttgcgcagt tccaggctga gaagcaggca gtgctggcag agctggcggc caaggccaag 1440 ctcaccgagc aggtcttcaa tgaggctcct ggcatcagct gcaacccagt gcagggcgcc 1500 atgtactcct tcccgcgcgt gcagctgccc ccgcgggcgg tggagcgcgc tcaggagctg 1560 ggcctggccc ccgatatgtt cttctgcctg cgcctcctgg aggagaccgg catctgcgtg 1620 gtgccaggga gcggctttgg gcagcgggaa ggcacctacc acttccggat gaccattctg 1680 ccccccttgg agaaactgcg gctgctgctg gagaagctga gcaggttcca tgccaagttc 1740 accctcgagt actcctgagc accccagctg gggccaggct gggtcgccct ggactgtgtg 1800 ctcaggagcc ctgggaggct ctggagccca ctgtacttgc tcttgatgcc tggcggggtg 1860 gggtgggggg ggtgctgggc ccctgcctct ctgcaggtcc ctaataaagc tgtgtggcag 1920 tctg 1924 <210> SEQ ID NO 7 <211> LENGTH: 1924 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 7 ccccgccttc acccactgcc tctgcctccc tggggcagag ctgtttccca gacgggtggg 60 gcggggccca actgtcccag ctccttcagc cctttctgtc cctcccagtg aggccagctg 120 cggtgaagag ggtgctctct tgcctggcgt tccctctgca cggctgcccc ctcccaccct 180 gcccactaag ccagacccac tgtcgccatt cccacttctg gtcctgccac ctcctgagct 240 gccttcccgc ctggtctggg tagagtcatg gcctcgagca caggtgaccg gagccaggcg 300 gtgaggcatg gactgagggc gaaggtgctg acgctggacg gcatgaaccc gcgtgtgcgg 360 agagtggagt acgcagtgcg tggccccata gtgcagcgag ccttggagct ggagcaggag 420 ctgcgccagg gtgtgaagaa gcctttcacc gaggtcatcc gtgccaacat cggggacgca 480 caggctatgg ggcagaggcc catcaccttc ctgcgccagg tcttggccct ctgtgttaac 540 cctgatcttc tgagcagccc caacttccct gacgatgcca agaaaagggc ggagcgcatc 600 ttgcaggcgt gtgggggcca cagtctgggg gcctacagcg tcagctccgg catccagctg 660 atccgggagg acgtggcgcg gtacattgag aggcgtgacg gaggcatccc tgcggacccc 720 aacaacgtct tcctgtccac aggggccagc gatgccatcg tgacggtgct gaagctgctg 780 gtggccggcg agggccacac acgcacgggt gtgctcatcc ccatccccca gtacccactc 840 tactcggcca cgctggcaga gctgggcgca gtgcaggtgg attactacct ggacgaggag 900 cgtgcctggg cgctggacgt ggccgagctt caccgtgcac tgggccaggc gcgtgaccac 960 tgccgccctc gtgcgctctg tgtcatcaac cctggcaacc ccaccgggca ggtgcagacc 1020 cgcgagtgca tcgaggccgt gatccgcttc gccttcgaag agcggctctt tctgctggcg 1080 gacgaggtgt accaggacaa cgtgtacgcc gcgggttcgc agttccactc attcaagaag 1140 gtgctcatgg agatggggcc gccctacgcc gggcagcagg agcttgcctc cttccactcc 1200 acctccaagg gctacatggg cgagtgcggg ttccgcggcg gctatgtgga ggtggtgaac 1260 atggacgctg cagtgcagca gcagatgctg aagctgatga gtgtgcggct gtgcccgccg 1320 gtgccaggac aggccctgct ggacctggtg gtcagcccgc ccgcgcccac cgacccctcc 1380 tttgcgcagt tccaggctga gaagcaggca gtgctggcag agctggcggc caaggccaag 1440 ctcaccgagc aggtcttcaa tgaggctcct ggcatcagct gcaacccagt gcagggcgcc 1500 atgtactcct tcccgcgcgt gcagctgccc ccgcgggcgg tggagcgcgc tcaggagctg 1560 ggcctggccc ccgatatgtt cttctgcctg cgcctcctgg aggagaccgg catctgcgtg 1620 gtgccaggga gcggctttgg gcagcgggaa ggcacctacc acttccggat gaccattctg 1680 ccccccttgg agaaactgcg gctgctgctg gagaagctga gcaggttcca tgccaagttc 1740 accctcgagt actcctgagc accccagctg gggccaggct gggtcgccct ggactgtgtg 1800 ctcaggagcc ctgggaggct ctggagccca ctgtacttgc tcttgatgcc tggcggggtg 1860 gggtgggggg ggtgctgggc ccctgcctct ctgcaggtcc ctaataaagc tgtgtggcag 1920 tctg 1924 <210> SEQ ID NO 8 <211> LENGTH: 9432 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 gccgtggctc cggtagcagc aagttcgaac cccgctcccg ctccgcttcg gttctcgctc 60 cttcggccct tgggcctcca aacaccagtc cccggcagct cgttgcgcat tgcgctctcc 120 ccgccaccag gatgccggta accgagaagg atctagctga ggacgcgcct tggaagaaga 180 tccagcagaa cacgttcaca cgctggtgca acgagcacct caagtgcgtg aacaaacgca 240 tcggcaacct gcagaccgac ctgagcgacg ggctgcggct catcgcgctg ctcgaggtgc 300 tcagccagaa gcgcatgtac cgcaagtacc atcagcggcc cacctttcgc cagatgcagc 360 tcgagaatgt gtccgtggcg ctcgagttcc tggaccgtga gagcatcaag ctcgtgtcca 420 tcgatagcaa agccattgtg gatgggaacc tgaagctcat cttgggtctg gtgtggacgc 480 tgatcctcca ctactccatc tccatgcccg tgtgggagga tgaaggggat gatgatgcca 540 agaagcagac gccaaagcag aggctgctgg ggtggattca gaacaagatc ccctacttgc 600 ccatcaccaa ctttaaccag aactggcaag acggcaaagc cctgggagcc ctggtagaca 660 gctgtgctcc aggtctgtgc ccagactggg aatcctggga cccgcagaag cctgtggata 720 atgcacgaga agccatgcag caggcagatg actggctggg tgtcccacag gtcatcactc 780 ctgaagaaat cattcacccg gatgtggacg agcactcagt tatgacttac ctgtcccagt 840 tccccaaagc caagctcaag ccgggggctc ctctcaaacc caaactcaac ccgaagaaag 900 ccagggccta tggcagagga atcgagccca ctggaaacat ggtgaagcag ccagccaagt 960 tcactgtgga caccatcagc gccgggcaag gagacgtgat ggtgtttgtt gaggacccag 1020 aagggaacaa agaggaggca caagtgaccc ctgacagcga caagaacaag acatactctg 1080 tggagtatct gcccaaggtc accgggctac acaaagtcac agtcctcttt gcaggacagc 1140 acatctccaa gagcccattt gaagtgagtg ttgacaaggc ccagggagat gccagtaaag 1200 tcactgcaaa aggtccaggg ttggaagctg tagggaacat cgccaataag cccacctact 1260 ttgacatcta tacggcagga gctggtgtgg gtgacattgg tgtggaggtg gaagatcccc 1320 aggggaagaa caccgtggag ttgctcgtgg aagacaaagg aaaccaggtg tatcgatgtg 1380 tgtacaaacc catgcagcct ggccctcacg tggtcaagat cttctttgct ggggacacta 1440 ttcctaagag tcccttcgtt gtgcaggttg gggaagcctg caatccaaat gcctgccggg 1500 ccagtggccg aggcctacaa cccaaaggcg tccgtatccg ggagaccaca gatttcaagg 1560 ttgacaccaa agctgcagga agtggggagc tcggggtaac catgaagggt cctaagggtc 1620 tggaggagct ggtgaagcag aaagactttc tggatggggt ctacgcattc gagtattacc 1680 ccagcacccc ggggagatac agcattgcca tcacatgggg gggacaccac attccaaaga 1740 gcccctttga agttcaagtt ggccctgaag cgggtatgca gaaagtccgt gcttggggcc 1800 ctgggctcca tggtgggatt gtcgggcggt cagcggactt cgtggtagaa tccattggct 1860

ctgaagtggg gtctctgggg tttgccattg aaggcccctc tcaggcaaag attgagtaca 1920 acgaccagaa tgatggatcg tgtgatgtca aatactggcc caaggagcct ggcgaatatg 1980 ctgttcacat catgtgtgac gacgaagaca tcaaggacag cccgtacatg gccttcatcc 2040 acccagccac gggaggctac aaccctgatc tggttcgagc atacgggcca ggtttggaga 2100 aatctggatg cattgtcaac aacctggccg agttcactgt ggatcctaag gatgctggaa 2160 aagctccctt aaagatattt gctcaggatg gggaaggcca acgcattgac atccagatga 2220 agaaccggat ggacggcaca tatgcatgct catacacccc ggtgaaggcc atcaagcaca 2280 ccattgctgt ggtctgggga ggcgtgaaca tcccgcacag cccctacagg gtcaacatcg 2340 ggcaaggtag ccatcctcag aaggtcaaag tgtttgggcc aggtgtggag agaagtggtc 2400 tgaaggcaaa tgaacctaca cacttcacgg tggactgtac tgaggctggg gaaggtgatg 2460 tcagtgttgg cattaagtgt gatgcccggg tgttaagtga agatgaggaa gacgtggatt 2520 ttgacattat tcacaatgcc aatgatacgt tcacagtcaa atatgtgcct cctgctgctg 2580 ggcgatacac tatcaaagtt ctctttgcat ctcaggaaat ccccgccagc cctttcagag 2640 tcaaagttga cccttcccac gatgccagca aagtgaaggc agaaggccca gggctcagca 2700 aagcaggtgt ggaaaatggg aaaccgaccc acttcactgt ctacaccaag ggggctggga 2760 aagccccgct caacgtgcag ttcaacagcc ctcttcctgg cgatgcagtg aaggatttgg 2820 atatcatcga taattatgac tactctcaca cggttaaata tacacccacc caacagggca 2880 acatgcaggt tctggtgact tacggtggcg atcccatccc taaaagccct ttcactgtgg 2940 gtgttgctgc accgctggat ctgagcaaga taaaactcaa tgggctggaa aacagggtgg 3000 aagttgggaa ggatcaggag ttcaccgttg ataccagggg ggcaggaggc caggggaagc 3060 tggacgtgac aatcctcagc ccctctcgga aggtcgtgcc atgcctagtg acacctgtga 3120 caggccggga gaacagcacg gccaagttca tccctcggga ggaggggctg tatgctgtag 3180 acgtgaccta cgatggacac cctgtgcccg ggagccccta cacagtggag gcctcgctgc 3240 caccagatcc cagcaaggtg aaggcccacg gtcccggcct cgaaggtggt ctcgtgggca 3300 agcctgccga gttcaccatc gataccaaag gagctggtac tggaggtctg ggcttaacgg 3360 tggaaggtcc gtgcgaggcc aaaatcgagt gctccgacaa tggtgatggg acctgctccg 3420 tctcttacct tcccacaaaa cccggggagt acttcgtcaa catcctcttt gaagaagtcc 3480 acatacctgg gtctcccttc aaagctgaca ttgaaatgcc ctttgacccc tctaaagtcg 3540 tggcatcggg gccaggtctc gagcacggga aggtgggtga agctggcctc cttagcgtca 3600 actgctcgga agcgggaccg ggggccctgg gcctggaagc tgtctcggac tcgggaacaa 3660 aagccgaagt cagtattcag aacaacaaag atggcaccta cgcggtgacc tacgtgcccc 3720 tgacggccgg catgtacacg ttgaccatga agtatggtgg cgaactcgtg ccacacttcc 3780 ccgcccgggt caaggtggag cccgccgtgg acaccagcag gatcaaagtc tttggaccag 3840 gaatagaagg gaaagatgtg ttccgggaag ctaccaccga ctttacagtt gactctcggc 3900 cgctgaccca ggttgggggt gaccacatca aggcccacat tgccaacccc tcaggggcct 3960 ccaccgagtg ctttgtcaca gacaatgcgg atgggaccta ccaggtggaa tacacaccct 4020 ttgagaaagg tctccatgta gtggaggtga catatgatga cgtgcctatc ccaaacagtc 4080 ccttcaaggt ggctgtcact gaaggctgcc agccatctag ggtgcaagcc caaggacctg 4140 gattgaaaga ggcctttacc aacaagccca atgtcttcac cgtggttacc agaggcgcag 4200 gaattggtgg gcttggcata actgttgagg gaccatcaga gtcgaagata aattgcagag 4260 acaacaagga tggcagctgc agtgctgagt acattccttt cgcgccgggg gattacgatg 4320 ttaatatcac atatggagga gcccacatcc ctggcagccc cttcagggtt cctgtgaagg 4380 atgttgtgga ccccagcaag gtcaagattg ccggccccgg gctgggctca ggcgtccgag 4440 cccgtgtcct gcagtccttc acggtggaca gcagcaaggc tggcctggct ccgctggaag 4500 tgagggttct gggcccacga ggcttggtgg agccagtgaa catggtggac aatggagatg 4560 gcacacacac agtaacctac accccatctc aggagggacc ttacatggtc tcagttaaat 4620 atgctgatga agagattcct cgcagtccct tcaaggtcaa ggtccttccc acatatgatg 4680 ccagcaaagt gactgccagt ggccccggcc ttagttccta tggtgtgcct gccagtctac 4740 ctgtggactt tgcaattgat gcccgagatg ccggggaagg cctgcttgct gttcaaataa 4800 cggaccaaga aggaaaaccc aaaagagcca ttgtccatga caataaagat ggcacgtatg 4860 ctgtcaccta catccccgac aagactgggc gctatatgat tggagtcacc tacgggggtg 4920 acgacatccc actttctcct tatcgcatcc gagccacaca gacgggtgat gccagcaagt 4980 gcctggccac gggtcctgga atcgcctcca ctgtgaaaac tggcgaagaa gtaggctttg 5040 tggttgatgc caagactgcc gggaagggta aagtgacctg cacggttctg accccagatg 5100 gcactgaggc cgaggccgat gtcattgaga atgaagatgg aacctatgac atcttctaca 5160 cagctgccaa gccgggcaca tatgtgatct atgtgcgctt cggtggtgtt gatattccta 5220 acagcccctt cactgtcatg gccacagatg gggaagtcac agccgtggag gaggcaccgg 5280 taaatgcatg tccccctgga ttcaggccct gggtgaccga agaggcctat gtcccagtga 5340 gtgacatgaa cggcctggga tttaagcctt ttgacctggt cattccgttt gctgtcagga 5400 aaggagaaat cactggagag gtccacatgc cttctgggaa gacagccaca cctgagattg 5460 tggacaacaa ggacggcacg gtcactgtta gatatgcccc cactgaggtc gggctccatg 5520 agatgcacat caaatacatg ggcagccaca tccctgagag cccactccag ttctacgtga 5580 actaccccaa cagtggaagt gtttctgcat acggtccagg cctcgtgtat ggagtggcca 5640 acaaaactgc caccttcacc atcgtcacag aggatgcagg agaaggtggt ctggacttgg 5700 ctattgaggg cccctcaaaa gcagaaatca gctgcattga caataaagat gggacatgca 5760 cagtgaccta cctgccgact ctgccaggcg actacagcat tctggtcaag tacaatgaca 5820 agcacatccc tggcagcccc ttcacagcca agatcacaga tgacagcagg cggtgctccc 5880 aggtgaagtt gggctcagcc gctgacttcc tgctcgacat cagtgagact gacctcagca 5940 gcctgacggc cagcattaag gccccatctg gccgagacga gccctgtctc ctgaagaggc 6000 tgcccaacaa ccacattggc atctccttca tcccccggga agtgggcgaa catctggtca 6060 gcatcaagaa aaatggcaac catgtggcca acagccccgt gtctatcatg gtggtccagt 6120 cggagattgg tgacgcccgc cgagccaaag tctatggccg cggcctgtca gaaggccgga 6180 ctttcgagat gtctgacttc atcgtggaca caagggatgc aggttatggt ggcatatcct 6240 tggcggtgga aggccccagc aaagtggaca tccagacgga ggacctggaa gatggcacct 6300 gcaaagtctc ctacttccct accgtgcctg gggtttatat cgtctccacc aaattcgctg 6360 acgagcacgt gcctgggagc ccatttaccg tgaagatcag tggggaggga agagtcaaag 6420 agagcatcac ccgcaccagt cgggccccgt ccgtggccac tgtcgggagc atttgtgacc 6480 tgaacctgaa aatcccagaa atcaacagca gtgatatgtc ggcccacgtc accagcccct 6540 ctggccgtgt gactgaggca gagattgtgc ccatggggaa gaactcacac tgcgtccggt 6600 ttgtgcccca ggagatgggc gtgcacacgg tcagcgtcaa gtaccgtggg cagcacgtca 6660 ccggcagccc cttccagttc accgtggggc cacttggtga aggaggcgcc cacaaggtgc 6720 gggcaggagg ccctggcctg gagagaggag aagcgggagt cccagctgag ttcagcattt 6780 ggacccggga agcaggcgct ggaggcctct ccatcgctgt tgagggcccc agtaaggccg 6840 agattacatt cgatgaccat aaaaatgggt cgtgcggtgt atcttatatt gcccaagagc 6900 ctggtaacta cgaggtgtcc atcaagttca atgatgagca catcccggaa agcccctacc 6960 tggtgccggt catcgcaccc tccgacgacg cccgccgcct cactgttatg agccttcagg 7020 aatcgggatt aaaagttaac cagccagcat cctttgctat aaggttgaat ggcgcaaaag 7080 gcaagattga tgcaaaggtg cacagcccct ctggagccgt ggaggagtgc cacgtgtctg 7140 agctggagcc agataagtat gctgttcgct tcatccctca tgagaatggt gtccacacca 7200 tcgatgtcaa gttcaatggg agccacgtgg ttggaagccc cttcaaagtg cgcgttgggg 7260 agcctggaca agcggggaac cctgccctgg tgtccgccta tggcacggga ctcgaagggg 7320 gcaccacagg tatccagtcg gaattcttta ttaacaccac ccgagcaggt ccagggacat 7380 tatccgtcac catcgaaggc ccatccaagg ttaaaatgga ttgccaggaa acacctgaag 7440 ggtacaaagt catgtacacc cccatggctc ctggtaacta cctgatcagt gtcaaatacg 7500 gtgggcccaa ccacatcgtg ggcagtccct tcaaggccaa ggtgacaggc cagcgtctag 7560 ttagccctgg ctcagccaac gagacctcat ccatcctggt ggagtcagtg accaggtcgt 7620 ctacagagac ctgctatagc gccattccca aggcatcctc ggacgccagc aaggtgacct 7680 ctaagggggc agggctctca aaggcctttg tgggccagaa gagttccttc ctggtggact 7740 gcagcaaagc tggctccaac atgctgctga tcggggtcca tgggcccacc accccctgcg 7800 aggaggtctc catgaagcat gtaggcaacc agcaatacaa cgtcacatac gtcgtcaagg 7860 agaggggcga ttatgtgctg gctgtgaagt ggggggagga acacatccct ggcagccctt 7920 ttcatgtcac agtgccttaa aacagttttc tcaaatcctg gagagagttc ttgtggttgc 7980 ttttgttgct tgtttgtaat tcattttata caaagccctc cagcctgttt gtggggctga 8040 aaccccatcc ctaaaatatt gctgttgtaa aatgccttca gaaataagtc ctagactgga 8100 ctcttgaggg acatattgga gaatcttaag aaatgcaagc ttgttcaggg ggctgagaag 8160 atcctgagta cactaggtgc aaaccagaac tcttggtgga acagaccagc cactgcagca 8220 gacagaccag gaacacaatg agactgacat ttcaaaaaaa caaaactggc tagcctgagc 8280 tgctggttca ctcttcagca tttatgaaac aaggctaggg gaagatgggc agagaaaaag 8340 gggacaccta gtttggttgt catttggcaa aggagatgac ttaaaatccg cttaatctct 8400 tccagtgtcc gtgttaatgt atttggctat tagatcacta gcactgcttt accgctcctc 8460 atcgccaaca cccccatgct ctgtggcctt cttacacttc tcagagggca gagtggcagc 8520 cgggcaccct acagaaactc agagggcaga gtggcagcca ggcccacatg tctctcaagt 8580 acctgtcccc tcgctctggt gattatttct tgcagaatca ccacacgaga ccatcccggc 8640 agtcatggtt ttgctttagt tttccaagtc cgtttcagtc ccttccttgg tctgaagaaa 8700 ttctgcagtg gcgagcagtt tcccacttgc caaagatccc ttttaaccaa cactagccct 8760 tgtttttaac acacgctcca gcccttcatc agcctgggca gtcttaccaa aatgtttaaa 8820 gtgatctcag aggggcccat ggattaacgc cctcatccca aggtccgtcc catgacataa 8880 cactccacac ccgccccagc caacttcatg ggtcactttt tctggaaaat aatgatctgt 8940 acagacagga cagaatgaaa ctcctgcggc tctttggcct gaaagttggg aatggttggg 9000 ggagagaagg gcagcagctt attggtggtc ttttcaccat tggcagaaac agtgagagct 9060 gtgtggtgca gaaatccaga aatgaggtgt agggaatttt gcctgccttc ctgcagacct 9120 gagctggctt tggaatgagg ttaaagtgtc agggacgttg cctgagccca aatgtgtagt 9180 gtggtctggg caggcagacc tttaggtttt gctgcttagt cctgaggaag tggccactct 9240 tgtggcaggt gtagtatctg gggcgagtgt tgggggtaaa agcccaccct acagaaagtg 9300 gaacagcccg gacctgatgt gaaaggacca cgggtgttgt aagctgggac cggaaccaaa 9360

ctggaatcaa acgcgactgt aaattgtatc ttataactta ttaaataaaa cattgctccg 9420 taaaaaaaaa aa 9432 <210> SEQ ID NO 9 <211> LENGTH: 2193 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 9 cgatgatgat tcagtggaat gggcccaaga ccagcatttc tgagaaggct cgggggctgg 60 ctttgaccta cagcctccgg gacagggaac gtggtggtgg tcgtgcacag attggtgtgg 120 tggatgatga ggccaaagcc ccggacctca tgcagatcat ggaggctgtg ctgggctgca 180 gggtgggcag cctgcgtgcc gccacgccca gcaaggatat caaccagctg cagaaggcca 240 atgttcgcct gtaccatgtc tatgagaagg gcaaagacct ggtggtcctg gagttggcga 300 cccccccact gacccaggac ctgctgcagg aggaggactt ctacatcctg gaccagggtg 360 gcttcaagat ctatgtgtgg cagggacgca tgtctagcct ccaggagaga aaggctgcct 420 tcagccgggc tgtgggcttc atccaggcca agggctaccc gacctacacc aacgtggagg 480 tggtgaacga cggcgccgag tcggccgcgt tcaagcagct cttccggact tggtctgaga 540 agcggcgcag gaaccagaag ctcggcggga gggataaatc gattcatgta aagctggacg 600 tgggcaagct gcacacccag cctaagttag cggcccagct caggatggtg gacgacggct 660 ctgggaaggt ggaggtgtgg tgcatccagg acttacacag gcagcccgtg gaccccaagc 720 gtcatggaca gctgtgtgca ggcaactgct accttgtgct ctacacatac cagaggctgg 780 gccgtgttca gtacatcctg tacctatggc agggccacca ggccactgcg gatgagattg 840 aggccctgaa cagcaacgct gaggaactag atgtcatgta tggtggcgtc ctagtacagg 900 agcatgtgac catgggcagc gagccccccc acttcctcgc catcttccag ggccagctgg 960 tgatcttcca ggagagagct gggcaccatg gaaaggggca gtcagcatcc accacaaggc 1020 ttttccaagt gcaaggcact gacagccaca acaccaggac catggaggtg ccagcccgtg 1080 cctcatccct caactccagt gacatcttct tgctggtcac agccagcgtc tgctacctct 1140 ggtttgggaa gggctgtaat ggtgatcagc gtgagatggc acgggtggtg gtcactgtca 1200 tttccaggaa gaatgaggaa acggtgctgg agggtcagga gcctccccac ttctgggagg 1260 ccctgggagg ccgggccccc taccccagca acaagaggct ccctgaggag gtccccagct 1320 tccagccacg actgtttgag tgctccagcc acatgggctg cctggtcctc gcagaagtgg 1380 ggttcttcag ccaggaggac ctggacaagt atgacatcat gttactggac acctggcagg 1440 agatcttcct gtggcttggg gaagctgcaa gtgagtggaa ggaggcggtg gcctggggcc 1500 aggagtacct gaagactcac ccagcaggga ggagcccggc cacacccatc gtgctggtca 1560 agcagggcca tgagcctccc accttcattg gatggttctt cacttgggac ccctacaagt 1620 ggactagcca cccgtcccac aaggaagtgg tggatggcag cccggcagca gcatcaacca 1680 tctctgagat aacagcagaa gtcaacaact tgcggctatc cagatggccg ggcaatggca 1740 gggcaggtgc cgtggccctg caggccctca agggctccca ggacagctca gagaatgatc 1800 tggtgcgaag ccccaagtcg gctggcagca gaaccagcag ctccgtcagc agcaccagcg 1860 ccacgatcaa cgggggcctg cgccgggaac aactgatgca ccaggctgtt gaggacctgc 1920 cagagggcgt ggaccctgcc cgcagggagt tctatctctc agactctgac ttccaagata 1980 tctttgggaa atccaaggag gaattctaca gcatggccac gtggaggcag cggcaggaga 2040 aaaagcagct gggcttcttc tgaacccaag ccctctcgac tgcccctatc ccctggaccc 2100 caacatacct acaatgctgg ggaggccctg cttccactcc cctcagaggc ttttggtcat 2160 cctctgcgtg tcagtaaaag caggcagccc ata 2193 <210> SEQ ID NO 10 <211> LENGTH: 2089 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 gcggccgctc cgtgtgccct ggactcgccg cccgcggctc ggaagctgga gagtcagcga 60 cggggcccga ctgcgggacc gagggctgca agaagaagcg aacaaatagt ccccagcgcc 120 tcctctggat gcggtcgcgt ctgtggtcct ggcagccgct gggcgggcca ggccaggtcg 180 ggccgggccg agccgggcac atggacctgg gcctgcgggc tctaattgcg gcgcttatgt 240 tgatgatttt ttttttaatc acagcagccc ccagtttagc ggactgattt actcccggta 300 ttggtaaata tgatcacgtg ggccgcgcga ccaatggtgg aggctgcagc ctgcgaacta 360 gtcggtggct cgggcgccgg cggggagctg ctcggcggcg gacagtgtaa tgttgggtgg 420 gagtgcggga cgcctcaaaa tgtcttccag tggcaccctc agcaactact acgtggactc 480 gcttataggc catgagggcg acgaggtgtt cgcggcgcgc ttcgggccgc cggggccagg 540 cgcgcagggc cggcctgcag gtgtggctga tggcccggcc gccaccgccg ccgagttcgc 600 ctcgtgtagt tttgccccca gatcggccgt gttctctgcc tcgtggtccg cggtgccctc 660 ccagcccccg gcagcggcgg cgatgagcgg cctctaccac ccgtacgttc ccccgccgcc 720 cctggccgcc tctgcctccg agcccggccg ctacgtgcgc tcctggatgg agccgctgcc 780 cggcttcccg ggcggtgcgg gcggtggcgg tggtggtgga ggcggcggtc cgggccgcgg 840 tcccagccct ggccccagcg gcccagccaa cgggcgccac tacgggatta agcctgaaac 900 ccgagcggcc ccggcccccg ccacggccgc ctccaccacc tcctcctcct ccacttcctt 960 atcctcctcc tccaaacgga ctgagtgctc cgtggcccgg gagtcccagg ggagcagcgg 1020 ccccgagttc tcgtgcaact cgttcctgca ggagaaggcg gcagcggcga cggggggaac 1080 cgggcctggg gcagggatcg gggccgcgac tgggacgggc ggctcgtcgg agccctcagc 1140 ttgcagcgac cacccgatcc caggctgttc gctgaaggag gaggagaagc agcattcgca 1200 gccgcagcag cagcaacttg acccaaacaa ccccgccgcg aactggatcc acgctcgctc 1260 cacccggaaa aagcgctgtc cctacaccaa ataccagacg cttgagctgg agaaagaatt 1320 cctcttcaac atgtacctca cccgggaccg gcgctacgag gtggccagga ttctcaacct 1380 aacagagaga caggtcaaaa tctggtttca gaaccgtagg atgaaaatga aaaagatgag 1440 caaggagaaa tgccccaaag gagactgacc cggcgcggtg ctggcgggag cgctcaaggg 1500 cagcggattt gttgttgttg ctgttttcct ttgtgggtgt ttggtgcttg atttccagaa 1560 actctccagc gacttggact tcttcttctt tttttttttc tttttagata gaagtgactg 1620 tgtggttggt ctctgaggta tttgggggac tctgtatttg ctcgtttacg tgttggaaaa 1680 accaagtggc tttggggttt cgccctatcc cactccctct ctttcctgct ccattggttc 1740 cttaagaaat gctatatttt gtgagtgcaa gctggcttgg ggagccctct cttgtgtaaa 1800 tgtcccccat gtttctgaaa agtgctgtag tttagtcccc tcacccccag cactgcccaa 1860 acaggggcca agtgcgcccc aattccaaga atgaaggcag agcgacaaca gtgcggacac 1920 cccggctgct agcccacggt gaagcccggc ggggttgccc accagttgcg aaagccccct 1980 ttcctcaggg agcacgcggg acctcggtgg agatctccag tgaggcttag aggagcccag 2040 ggcctcgggc gggttggggt ttgtcctcag tgcattggac gcgctgctc 2089 <210> SEQ ID NO 11 <211> LENGTH: 8019 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 11 gcggcccggt gcgggtgtcg gggagaccgg gctctctgcc cggcgcggcg cggcgcggct 60 cggcccacga gcgaccaccg acatggagtg ggctcgggcg gccaagtagc cgcttctccg 120 gagcccggtg ccagtgccgc ccgcagcccg ccttccaccc ccggccgcgc cgccggtcag 180 gccctagggt gaagccggga ggaaaatgaa gagttttcac cggaatccgt tgaaaatagg 240 actgactgca aagccttaaa gaaagaagga cctcgggagg agaaacgaaa agccgcctcc 300 gggcaagact tggcgtgctc cgagccgagg ggctgcttca gggacctcgc cccctccctt 360 tcccgctgga gaaattgccg ctgatgcatt atccaagtgg tggttgggag gatttgcagc 420 aacatttttg gttttccctc ccccttctat gcattctgtt tttttcctcc cttttctgtt 480 tttcttcttc ccgggaagtg aattgctgat gcaaatcgga ctttattcat taatgatgca 540 accggattcg tttcaggatt acgttgcacg agttgaattt tgaatgaagg agaagagttt 600 tttttttttt ttttaaagaa gtgttgactc tctagttcgt tgtactttta attattattt 660 tatttaaata tacgacttaa ttgtattctt ttaaaaatgc attaagtata tattttatgg 720 taatttaccc tcaaaatata tgtatatggg tgaaattgaa gacgcttcag ttaagtgagg 780 ttactggtgt gttggatgtt taattcagca ccagcattgc atgacagttg tttgaataac 840 aagtggttta tttttaaaac catacctttt aaaatttagg ttcagataat agtaaaagtc 900 atcataataa tttaaaggaa aaccagcaga aatcgaagca aacatgtctg gagaagtgcg 960 tttgaggcag ttggagcagt ttattttgga cgggcccgct cagaccaatg ggcagtgctt 1020 cagtgtggag acattactgg atatactcat ctgcctttat gatgaatgca ataattctcc 1080 attgagaaga gagaagaaca ttctcgaata cctagaatgg gctaaaccat ttacttctaa 1140 agtgaaacaa atgcgattac atagagaaga ctttgaaata ttaaaggtga ttggtcgagg 1200 agcttttggg gaggttgctg tagtaaaact aaaaaatgca gataaagtgt ttgccatgaa 1260 aatattgaat aaatgggaaa tgctgaaaag agctgagaca gcatgttttc gtgaagaaag 1320 ggatgtatta gtgaatggag acaataaatg gattacaacc ttgcactatg ctttccagga 1380 tgacaataac ttatacctgg ttatggatta ttatgttggt ggggatttgc ttactctact 1440 cagcaaattt gaagatagat tgcctgaaga tatggctaga ttttacttgg ctgagatggt 1500 gatagcaatt gactcagttc atcagctaca ttatgtacac agagacatta aacctgacaa 1560 tatactgatg gatatgaatg gacatattcg gttagcagat tttggttctt gtctgaagct 1620 gatggaagat ggaacggttc agtcctcagt ggctgtagga actccagatt atatctctcc 1680 tgaaatcctt caagccatgg aagatggaaa agggagatat ggacctgaat gtgactggtg 1740 gtctttgggg gtctgtatgt atgaaatgct ttacggagaa acaccatttt atgcagaatc 1800 gctggtggag acatacggaa aaatcatgaa ccacaaagag aggtttcagt ttccagccca 1860 agtgactgat gtgtctgaaa atgctaagga tcttattcga aggctcattt gtagcagaga 1920 acatcgactt ggtcaaaatg gaatagaaga ctttaagaaa cacccatttt tcagtggaat 1980 tgattgggat aatattcgga actgtgaagc accttatatt ccagaagtta gtagcccaac 2040 agatacatcg aattttgatg tagatgatga ttgtttaaaa aattctgaaa cgatgccccc 2100 accaacacat actgcatttt ctggccacca tctgccattt gttggtttta catatactag 2160 tagctgtgta ctttctgatc ggagctgttt aagagttacg gctggtccca cctcactgga 2220 tcttgatgtt aatgttcaga ggactctaga caacaactta gcaactgaag cttatgaaag 2280 aagaattaag cgccttgagc aagaaaaact tgaactcagt agaaaacttc aagagtcaac 2340 acagactgtc caagctctgc agtattcaac tgttgatggt ccactaacag caagcaaaga 2400

tttagaaata aaaaacttaa aagaagaaat tgaaaaacta agaaaacaag taacagaatc 2460 aagtcatttg gaacagcaac ttgaagaagc taatgctgtg aggcaagaac tagatgatgc 2520 ttttagacaa atcaaggctt atgaaaaaca aatcaaaacg ttacaacaag aaagagaaga 2580 tctaaataag gaactagtcc aggctagtga gcgattaaaa aaccaatcca aagagctgaa 2640 agacgcacac tgtcagagga aactggccat gcaggaattc atggagatca atgagcggct 2700 aacagaattg cacacccaaa aacagaaact tgctcgccat gtccgagata aggaagaaga 2760 ggtggacctg gtgatgcaaa aagttgaaag cttaaggcaa gaactgcgca gaacagaaag 2820 agccaaaaaa gagctggaag ttcatacaga agctctagct gctgaagcat ctaaagacag 2880 gaagctacgt gaacagagtg agcactattc taagcaactg gaaaatgaat tggagggact 2940 gaagcaaaaa caaattagtt actcaccagg agtatgcagc atagaacatc agcaagagat 3000 aaccaaacta aagactgatt tggaaaagaa aagtatcttt tatgaagaag aattatctaa 3060 aagagaagga atacatgcaa atgaaataaa aaatcttaag aaagaactgc atgattcaga 3120 aggtcagcaa cttgctctca acaaagaaat tatgatttta aaagacaaat tggaaaaaac 3180 cagaagagaa agtcaaagtg aaagggagga atttgaaagt gagttcaaac aacaatatga 3240 acgagaaaaa gtgttgttaa ctgaagaaaa taaaaagctg acgagtgaac ttgataagct 3300 tactactttg tatgagaact taagtataca caaccagcag ttagaagaag aggttaaaga 3360 tctagcagac aagaaagaat cagttgcaca ttgggaagcc caaatcacag aaataattca 3420 gtgggtcagc gatgaaaagg atgcacgagg gtatcttcag gccttagctt ctaaaatgac 3480 tgaagaattg gaggcattaa gaaattccag cttgggtaca cgagcaacag atatgccctg 3540 gaaaatgcgt cgttttgcga aactggatat gtcagctaga ctggagttgc agtcggctct 3600 ggatgcagaa ataagagcca aacaggccat ccaagaagag ttgaataaag ttaaagcatc 3660 taatatcata acagaatgta aactaaaaga ttcagagaag aagaacttgg aactactctc 3720 agaaatcgaa cagctgataa aggacactga agagcttaga tctgaaaagg gtatagagca 3780 ccaagactca cagcattctt tcttggcatt tttgaatacg cctaccgatg ctctggatca 3840 atttgaaact gtagactcca ctccactttc agttcacaca ccaaccttaa ggaaaaaagg 3900 atgtcctggt tcaactggct ttccacctaa gcgcaagact caccagtttt ttgtaaaatc 3960 ttttactact cctaccaagt gtcatcagtg tacctccttg atggtgggtt taataagaca 4020 gggctgttca tgtgaagtgt gtggattctc atgccatata acttgtgtaa acaaagctcc 4080 aaccacttgt ccagttcctc ctgaacagac aaaaggtccc ctgggtatag atcctcagaa 4140 aggaatagga acagcatatg aaggtcatgt caggattcct aagccagctg gagtgaagaa 4200 agggtggcag agagcactgg ctatagtgtg tgacttcaaa ctctttctgt acgatattgc 4260 tgaaggaaaa gcatctcagc ccagtgttgt cattagtcaa gtgattgaca tgagggatga 4320 agaattttct gtgagttcag tcttggcttc tgatgttatc catgcaagtc ggaaagatat 4380 accctgtata tttagggtca cagcttccca gctctcagca tctaataaca aatgttcaat 4440 cctgatgcta gcagacactg agaatgagaa gaataagtgg gtgggagtgc tgagtgaatt 4500 gcacaagatt ttgaagaaaa acaaattcag agaccgctca gtctatgttc ccaaagaggc 4560 ttatgacagc actctacccc tcattaaaac aacccaggca gccgcaatca tagatcatga 4620 aagaattgct ttgggaaacg aagaagggtt atttgttgta catgtcacca aagatgaaat 4680 tattagagtt ggtgacaata agaagattca tcagattgaa ctcattccaa atgatcagct 4740 tgttgctgtg atctcaggac gaaatcgtca tgtacgactt tttcctatgt cagcattgga 4800 tgggcgagag accgattttt acaagctgtc agaaactaaa gggtgtcaaa ccgtaacttc 4860 tggaaaggtg cgccatggag ctctcacatg cctgtgtgtg gctatgaaaa ggcaggtcct 4920 ctgttatgaa ctatttcaga gcaagacccg tcacagaaaa tttaaagaaa ttcaagtccc 4980 atataatgtc cagtggatgg caatcttcag tgaacaactc tgtgtgggat tccagtcagg 5040 atttctaaga taccccttga atggagaagg aaatccatac agtatgctcc attcaaatga 5100 ccatacacta tcatttattg cacatcaacc aatggatgct atctgcgcag ttgagatctc 5160 cagtaaagaa tatctgctgt gttttaacag cattgggata tacactgact gccagggccg 5220 aagatctaga caacaggaat tgatgtggcc agcaaatcct tcctcttgtt gttacaatgc 5280 accatatctc tcggtgtaca gtgaaaatgc agttgatatc tttgatgtga actccatgga 5340 atggattcag actcttcctc tcaaaaaggt tcgaccctta aacaatgaag gatcattaaa 5400 tcttttaggg ttggagacca ttagattaat atatttcaaa aataagatgg cagaagggga 5460 cgaactggta gtacctgaaa catcagataa tagtcggaaa caaatggtta gaaacattaa 5520 caataagcgg cgttattcct tcagagtccc agaagaggaa aggatgcagc agaggaggga 5580 aatgctacga gatccagaaa tgagaaataa attaatttct aatccaacta attttaatca 5640 catagcacac atgggtcctg gagatggaat acagatcctg aaagatctgc ccatgaaccc 5700 tcggcctcag gaaagtcgga cagtattcag tggctcagtc agtattccat ctatcaccaa 5760 atcccgccct gagccaggcc gctccatgag tgctagcagt ggcttgtcag caaggtcatc 5820 cgcacagaat ggcagcgcat taaagaggga attctctgga ggaagctaca gtgccaagcg 5880 gcagcccatg ccctccccgt cagagggctc tttgtcctct ggaggcatgg accaaggaag 5940 tgatgcccca gcgagggact ttgacggaga ggactctgac tctccgaggc attccacagc 6000 ttccaacagt tccaacctaa gcagcccccc aagcccagct tcaccccgaa aaaccaagag 6060 cctctccctg gagagcactg accgcgggag ctgggacccg tgagctgcct cagcactggg 6120 acctctcgct ctccgctccc tgccactcgc ctcctctcac tttcatctct tccctccacc 6180 tcgcctgctc ggcctgaaag ccaccagggg ctggcagcag tagcaggaca gggattcagg 6240 agttctgacg acacgactct cagatccacg cccccagcct aacagcaaca acaaagacag 6300 actttccgta gcagcttaga ttaacgttga tttcattcca tgcacttaga gttgctttca 6360 gtaacatttt acccctactc ccaaaggtag cttaaataga cagattacac aaatgtaagt 6420 gataagaata agattagaca gattttgctt tcacagtaga gtctcattat agtcctaaaa 6480 tagctcatgg gcttctccgc atccagaagg gagaattggt ccctggagtg gctcactaag 6540 ctcttaatca gcaaacgcag tgagtatcaa cctgattgtt gccaggaaat ccttatgaat 6600 taaaacaatg catattttac tacagtacag agtttaaatg aatacataaa tgtagaagta 6660 ctgaatgtat atatttaaaa ggagcctctt gtattcaaca aaagatggat gcatatataa 6720 gagagatgat ttaatttaaa gaaatatgtt gtttcttgtc tgtaatgtaa tgtaaagggt 6780 ggaaaggcct caagctcaca tttgtagaga gagagcgaga gaaatcagag ttccctttat 6840 tgccctgtcc tcaaactggt cataggctct agtcacctgg ggagctgtag aaaacacttg 6900 cagagccagg ttttgctggt ttggggcatg ccctgggcac cagagcttta acatttgaag 6960 ccacttcagc agcagcagca aaaggcgaac tcatctctac ccaagatgtt tcttttccta 7020 gtggtggaat ttgaacactt ctcacttttt attgtatttt atcttccgca gataaatgta 7080 gaaatacacg attctgtcac ctctgatccc ttccatctga aaggttacaa ggagtgttgt 7140 agcttctgaa ggtgcagaaa acaatttcta aaaatgcttt tattcctggg ctaatcctgt 7200 ccctccctaa gtcacagcga ggtgtctgtc ccagggctgg agatgcttcc caaggaggag 7260 tctgttttgt tgagagtggg cgtgggcttc ttcacataag cctggggaag gaagaaaaaa 7320 cggctttcat taccaaataa tgtaaaacct caaaagcaag ggcttcaaca gccttaacca 7380 aatattattc cccatagcca gtggaaaatg gatgtgacaa ccccagtgcg caggccagag 7440 tgagtgagcc cagcacggcg ctccgactgg cttcctctct caggtgctgg attgtggggt 7500 tagtggcatt tccagctgga ttcctcctgt tgtagttgcc ataaggaaat gagatgcaga 7560 atcagaagga tctatttcta cagaatcatt tcaccagtta agcacatgag tagagaaaga 7620 gataaaaata aaagtatctc atgaaggaaa gagattttgc ctctctttta cttttcacct 7680 aagtttctct gagaaataga gacaggattc tctctttaaa attcagtgaa aatgaagaaa 7740 gttttcctgc agttgctaac ctgagttgca gtgtttaagg ccatcatttc actgctgctg 7800 tctgtgactc cacgtctgtg tcactgaggt gacctgcgtg tcactgaggt ggccaccatg 7860 ctggcctgcg gcatgtgcag ggagctgagg ctgtttccag gtgatgctgc tgtgtggaga 7920 aggttctgag atgcagtgag ggaagaaagg atcctgctgg ggattccatt gtaagcacct 7980 ataatcggga attttcatgt aacagctttg acatttaaa 8019 <210> SEQ ID NO 12 <211> LENGTH: 7776 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 gcggcccggt gcgggtgtcg gggagaccgg gctctctgcc cggcgcggcg cggcgcggct 60 cggcccacga gcgaccaccg acatggagtg ggctcgggcg gccaagtagc cgcttctccg 120 gagcccggtg ccagtgccgc ccgcagcccg ccttccaccc ccggccgcgc cgccggtcag 180 gccctagggt gaagccggga ggaaaatgaa gagttttcac cggaatccgt tgaaaatagg 240 actgactgca aagccttaaa gaaagaagga cctcgggagg agaaacgaaa agccgcctcc 300 gggcaagact tggcgtgctc cgagccgagg ggctgcttca gggacctcgc cccctccctt 360 tcccgctgga gaaattgccg ctgatgcatt atccaagtgg tggttgggag gatttgcagc 420 aacatttttg gttttccctc ccccttctat gcattctgtt tttttcctcc cttttctgtt 480 tttcttcttc ccgggaagtg aattgctgat gcaaatcgga ctttattcat taatgatgca 540 accggattcg tttcaggatt acgttgcacg agttgaattt tgaatgaagg agaagagttt 600 tttttttttt ttttaaagaa gtgttgactc tctagttcgt tgtactttta attattattt 660 tatttaaata tacgacttaa ttgtattctt ttaaaaatgc attaagtata tattttatgg 720 taatttaccc tcaaaatata tgtatatggg tgaaattgaa gacgcttcag ttaagtgagg 780 ttactggtgt gttggatgtt taattcagca ccagcattgc atgacagttg tttgaataac 840 aagtggttta tttttaaaac catacctttt aaaatttagg ttcagataat agtaaaagtc 900 atcataataa tttaaaggaa aaccagcaga aatcgaagca aacatgtctg gagaagtgcg 960 tttgaggcag ttggagcagt ttattttgga cgggcccgct cagaccaatg ggcagtgctt 1020 cagtgtggag acattactgg atatactcat ctgcctttat gatgaatgca ataattctcc 1080 attgagaaga gagaagaaca ttctcgaata cctagaatgg gctaaaccat ttacttctaa 1140 agtgaaacaa atgcgattac atagagaaga ctttgaaata ttaaaggtga ttggtcgagg 1200 agcttttggg gaggttgctg tagtaaaact aaaaaatgca gataaagtgt ttgccatgaa 1260 aatattgaat aaatgggaaa tgctgaaaag agctgagaca gcatgttttc gtgaagaaag 1320 ggatgtatta gtgaatggag acaataaatg gattacaacc ttgcactatg ctttccagga 1380 tgacaataac ttatacctgg ttatggatta ttatgttggt ggggatttgc ttactctact 1440 cagcaaattt gaagatagat tgcctgaaga tatggctaga ttttacttgg ctgagatggt 1500 gatagcaatt gactcagttc atcagctaca ttatgtacac agagacatta aacctgacaa 1560 tatactgatg gatatgaatg gacatattcg gttagcagat tttggttctt gtctgaagct 1620

gatggaagat ggaacggttc agtcctcagt ggctgtagga actccagatt atatctctcc 1680 tgaaatcctt caagccatgg aagatggaaa agggagatat ggacctgaat gtgactggtg 1740 gtctttgggg gtctgtatgt atgaaatgct ttacggagaa acaccatttt atgcagaatc 1800 gctggtggag acatacggaa aaatcatgaa ccacaaagag aggtttcagt ttccagccca 1860 agtgactgat gtgtctgaaa atgctaagga tcttattcga aggctcattt gtagcagaga 1920 acatcgactt ggtcaaaatg gaatagaaga ctttaagaaa cacccatttt tcagtggaat 1980 tgattgggat aatattcgga actgtgaagc accttatatt ccagaagtta gtagcccaac 2040 agatacatcg aattttgatg tagatgatga ttgtttaaaa aattctgaaa cgatgccccc 2100 accaacacat actgcatttt ctggccacca tctgccattt gttggtttta catatactag 2160 tagctgtgta ctttctgatc ggagctgttt aagagttacg gctggtccca cctcactgga 2220 tcttgatgtt aatgttcaga ggactctaga caacaactta gcaactgaag cttatgaaag 2280 aagaattaag cgccttgagc aagaaaaact tgaactcagt agaaaacttc aagagtcaac 2340 acagactgtc caagctctgc agtattcaac tgttgatggt ccactaacag caagcaaaga 2400 tttagaaata aaaaacttaa aagaagaaat tgaaaaacta agaaaacaag taacagaatc 2460 aagtcatttg gaacagcaac ttgaagaagc taatgctgtg aggcaagaac tagatgatgc 2520 ttttagacaa atcaaggctt atgaaaaaca aatcaaaacg ttacaacaag aaagagaaga 2580 tctaaataag ctggaagttc atacagaagc tctagctgct gaagcatcta aagacaggaa 2640 gctacgtgaa cagagtgagc actattctaa gcaactggaa aatgaattgg agggactgaa 2700 gcaaaaacaa attagttact caccaggagt atgcagcata gaacatcagc aagagataac 2760 caaactaaag actgatttgg aaaagaaaag tatcttttat gaagaagaat tatctaaaag 2820 agaaggaata catgcaaatg aaataaaaaa tcttaagaaa gaactgcatg attcagaagg 2880 tcagcaactt gctctcaaca aagaaattat gattttaaaa gacaaattgg aaaaaaccag 2940 aagagaaagt caaagtgaaa gggaggaatt tgaaagtgag ttcaaacaac aatatgaacg 3000 agaaaaagtg ttgttaactg aagaaaataa aaagctgacg agtgaacttg ataagcttac 3060 tactttgtat gagaacttaa gtatacacaa ccagcagtta gaagaagagg ttaaagatct 3120 agcagacaag aaagaatcag ttgcacattg ggaagcccaa atcacagaaa taattcagtg 3180 ggtcagcgat gaaaaggatg cacgagggta tcttcaggcc ttagcttcta aaatgactga 3240 agaattggag gcattaagaa attccagctt gggtacacga gcaacagata tgccctggaa 3300 aatgcgtcgt tttgcgaaac tggatatgtc agctagactg gagttgcagt cggctctgga 3360 tgcagaaata agagccaaac aggccatcca agaagagttg aataaagtta aagcatctaa 3420 tatcataaca gaatgtaaac taaaagattc agagaagaag aacttggaac tactctcaga 3480 aatcgaacag ctgataaagg acactgaaga gcttagatct gaaaagggta tagagcacca 3540 agactcacag cattctttct tggcattttt gaatacgcct accgatgctc tggatcaatt 3600 tgaaactgta gactccactc cactttcagt tcacacacca accttaagga aaaaaggatg 3660 tcctggttca actggctttc cacctaagcg caagactcac cagttttttg taaaatcttt 3720 tactactcct accaagtgtc atcagtgtac ctccttgatg gtgggtttaa taagacaggg 3780 ctgttcatgt gaagtgtgtg gattctcatg ccatataact tgtgtaaaca aagctccaac 3840 cacttgtcca gttcctcctg aacagacaaa aggtcccctg ggtatagatc ctcagaaagg 3900 aataggaaca gcatatgaag gtcatgtcag gattcctaag ccagctggag tgaagaaagg 3960 gtggcagaga gcactggcta tagtgtgtga cttcaaactc tttctgtacg atattgctga 4020 aggaaaagca tctcagccca gtgttgtcat tagtcaagtg attgacatga gggatgaaga 4080 attttctgtg agttcagtct tggcttctga tgttatccat gcaagtcgga aagatatacc 4140 ctgtatattt agggtcacag cttcccagct ctcagcatct aataacaaat gttcaatcct 4200 gatgctagca gacactgaga atgagaagaa taagtgggtg ggagtgctga gtgaattgca 4260 caagattttg aagaaaaaca aattcagaga ccgctcagtc tatgttccca aagaggctta 4320 tgacagcact ctacccctca ttaaaacaac ccaggcagcc gcaatcatag atcatgaaag 4380 aattgctttg ggaaacgaag aagggttatt tgttgtacat gtcaccaaag atgaaattat 4440 tagagttggt gacaataaga agattcatca gattgaactc attccaaatg atcagcttgt 4500 tgctgtgatc tcaggacgaa atcgtcatgt acgacttttt cctatgtcag cattggatgg 4560 gcgagagacc gatttttaca agctgtcaga aactaaaggg tgtcaaaccg taacttctgg 4620 aaaggtgcgc catggagctc tcacatgcct gtgtgtggct atgaaaaggc aggtcctctg 4680 ttatgaacta tttcagagca agacccgtca cagaaaattt aaagaaattc aagtcccata 4740 taatgtccag tggatggcaa tcttcagtga acaactctgt gtgggattcc agtcaggatt 4800 tctaagatac cccttgaatg gagaaggaaa tccatacagt atgctccatt caaatgacca 4860 tacactatca tttattgcac atcaaccaat ggatgctatc tgcgcagttg agatctccag 4920 taaagaatat ctgctgtgtt ttaacagcat tgggatatac actgactgcc agggccgaag 4980 atctagacaa caggaattga tgtggccagc aaatccttcc tcttgttgtt acaatgcacc 5040 atatctctcg gtgtacagtg aaaatgcagt tgatatcttt gatgtgaact ccatggaatg 5100 gattcagact cttcctctca aaaaggttcg acccttaaac aatgaaggat cattaaatct 5160 tttagggttg gagaccatta gattaatata tttcaaaaat aagatggcag aaggggacga 5220 actggtagta cctgaaacat cagataatag tcggaaacaa atggttagaa acattaacaa 5280 taagcggcgt tattccttca gagtcccaga agaggaaagg atgcagcaga ggagggaaat 5340 gctacgagat ccagaaatga gaaataaatt aatttctaat ccaactaatt ttaatcacat 5400 agcacacatg ggtcctggag atggaataca gatcctgaaa gatctgccca tgaaccctcg 5460 gcctcaggaa agtcggacag tattcagtgg ctcagtcagt attccatcta tcaccaaatc 5520 ccgccctgag ccaggccgct ccatgagtgc tagcagtggc ttgtcagcaa ggtcatccgc 5580 acagaatggc agcgcattaa agagggaatt ctctggagga agctacagtg ccaagcggca 5640 gcccatgccc tccccgtcag agggctcttt gtcctctgga ggcatggacc aaggaagtga 5700 tgccccagcg agggactttg acggagagga ctctgactct ccgaggcatt ccacagcttc 5760 caacagttcc aacctaagca gccccccaag cccagcttca ccccgaaaaa ccaagagcct 5820 ctccctggag agcactgacc gcgggagctg ggacccgtga gctgcctcag cactgggacc 5880 tctcgctctc cgctccctgc cactcgcctc ctctcacttt catctcttcc ctccacctcg 5940 cctgctcggc ctgaaagcca ccaggggctg gcagcagtag caggacaggg attcaggagt 6000 tctgacgaca cgactctcag atccacgccc ccagcctaac agcaacaaca aagacagact 6060 ttccgtagca gcttagatta acgttgattt cattccatgc acttagagtt gctttcagta 6120 acattttacc cctactccca aaggtagctt aaatagacag attacacaaa tgtaagtgat 6180 aagaataaga ttagacagat tttgctttca cagtagagtc tcattatagt cctaaaatag 6240 ctcatgggct tctccgcatc cagaagggag aattggtccc tggagtggct cactaagctc 6300 ttaatcagca aacgcagtga gtatcaacct gattgttgcc aggaaatcct tatgaattaa 6360 aacaatgcat attttactac agtacagagt ttaaatgaat acataaatgt agaagtactg 6420 aatgtatata tttaaaagga gcctcttgta ttcaacaaaa gatggatgca tatataagag 6480 agatgattta atttaaagaa atatgttgtt tcttgtctgt aatgtaatgt aaagggtgga 6540 aaggcctcaa gctcacattt gtagagagag agcgagagaa atcagagttc cctttattgc 6600 cctgtcctca aactggtcat aggctctagt cacctgggga gctgtagaaa acacttgcag 6660 agccaggttt tgctggtttg gggcatgccc tgggcaccag agctttaaca tttgaagcca 6720 cttcagcagc agcagcaaaa ggcgaactca tctctaccca agatgtttct tttcctagtg 6780 gtggaatttg aacacttctc actttttatt gtattttatc ttccgcagat aaatgtagaa 6840 atacacgatt ctgtcacctc tgatcccttc catctgaaag gttacaagga gtgttgtagc 6900 ttctgaaggt gcagaaaaca atttctaaaa atgcttttat tcctgggcta atcctgtccc 6960 tccctaagtc acagcgaggt gtctgtccca gggctggaga tgcttcccaa ggaggagtct 7020 gttttgttga gagtgggcgt gggcttcttc acataagcct ggggaaggaa gaaaaaacgg 7080 ctttcattac caaataatgt aaaacctcaa aagcaagggc ttcaacagcc ttaaccaaat 7140 attattcccc atagccagtg gaaaatggat gtgacaaccc cagtgcgcag gccagagtga 7200 gtgagcccag cacggcgctc cgactggctt cctctctcag gtgctggatt gtggggttag 7260 tggcatttcc agctggattc ctcctgttgt agttgccata aggaaatgag atgcagaatc 7320 agaaggatct atttctacag aatcatttca ccagttaagc acatgagtag agaaagagat 7380 aaaaataaaa gtatctcatg aaggaaagag attttgcctc tcttttactt ttcacctaag 7440 tttctctgag aaatagagac aggattctct ctttaaaatt cagtgaaaat gaagaaagtt 7500 ttcctgcagt tgctaacctg agttgcagtg tttaaggcca tcatttcact gctgctgtct 7560 gtgactccac gtctgtgtca ctgaggtgac ctgcgtgtca ctgaggtggc caccatgctg 7620 gcctgcggca tgtgcaggga gctgaggctg tttccaggtg atgctgctgt gtggagaagg 7680 ttctgagatg cagtgaggga agaaaggatc ctgctgggga ttccattgta agcacctata 7740 atcgggaatt ttcatgtaac agctttgaca tttaaa 7776 <210> SEQ ID NO 13 <211> LENGTH: 2757 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 13 attgtaaact agtttttggt ttgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 60 aaaaaaaaaa aaggtctttt gtaactgact tctttcactt agcaaatgga agggtttttg 120 atggaatctt agctcagatg tcgccctagg cttggccttc tggaactcac tgttctcttg 180 cttccttcca ccctgcctcc ctacccgctt tgctacaaga agacagaatg tagaaacccc 240 cagttgactt tttgagtaga aatgagccat gttctattta gtggtagaat gtttgctggg 300 ttagcccagg acttcagatg gagtgcttcc tcctttttaa taccttgtga ctgctgtgtt 360 ggcaagcaga gggttaaatg ctgcaggagg acatgggaga gtttttgctt tgagggtcca 420 ctggagcaag agaagcttga gagtctgtct ctgagatccc agaacagaca tgaagatatg 480 gtaccgattc ccttggtgct aaaaggaact ccaggggaat ttcaggaaac ccctcctttt 540 ctcgtcttta ttctcacccc gtccccccgc cacctctctc cccaagttca cactcaggag 600 ggaggaatct tttacctttt ccgttctggg cagcagcctg tagggaatgt tatcagtgtt 660 gggactgggc acgggaccaa gccttcctgg tgcctggact gcaacctagc tgagagctga 720 catggcaggg cgagttgtgt gtgagttggc tgcccctagg ctcataggcc tagcacaata 780 gagaccctgt caatggaggg acactatcag gcaggtcact atcaatgtga cagacactat 840 caggcaggtc acattggtgc agatccttgg aggactcccc cccacccccc atgagtggat 900 tcctccaggt caggggctgg ctgggactgt ggatgctgga gtaagtggaa ttgtgggtgc 960 actctgcttc agcagtactc tccaaggaga atgattgttt taataaatta ctgttttaat 1020 aagggaggtg gaagagcttt ttaatcactt gctttttaaa aatttttaat tttattttaa 1080 ttaattagtt tatttatttt ttgagacgga gtcttgctct gtcgcccagg ctggagtgca 1140

gtggcacgat ctcggctcac tgcacctctg cctcctggat tcacaccatt ctcctgcctc 1200 agcctccaga gtagctggga ctacaggcac ccgccaccac gcccgactaa ttttttgtat 1260 ttttagcaga gacggggttt caccgtgtta gccaggatgg tgtagatctc ctgaccttgt 1320 gatcctcccg cctcagcctt ccaaagggag ggattactgg cgtgagtcac cgcgcctggc 1380 ctttattttt tatttctttt gagatggagt tttgctctgt cacccaggct ggagtaccgg 1440 tggtgggatc tcgcctcact gcaacttgcg cctcccgggt tcaagcgatt ctccagcctc 1500 agcctcctga gtagctggga ttacaggcgt gtgccaccgc ctccagctaa tttttgtatt 1560 tttagtagag accgggcttc accatgttgg ccaggctggt ctcgaactcc tgacctcagg 1620 tgagcgtcct gccttggcct cccaaagtgc tgggattaca ggcgtgagcc actacaccca 1680 gccaatcagt tgcttttaaa ctacttaaat aaaaagagcc aacccaaaat cttgtgcatg 1740 cttgggaaac tggcagtgga atatgagaag tttttatttg tggtgcacac aggtgactcg 1800 ggctgttgtg tattggttct tgcctcgatc tgtagcaagc aatctgttgt ttcttgcctg 1860 ccttttggga agaaatgaaa aaagaagcag cacgagtctc catacatcat gattgtgatg 1920 gcactgggcc tgagaccttt tctgctgtcc aggtaaaaat gtgaagacca tggttttgag 1980 gtttcttaat aaattcaggt gttaagtgcc aagtgatgct cccagcccct gagctagagc 2040 aactatgctg ttcatgtccc caggaatgga agtggaccct agttaggtgc tggtggccag 2100 ccatgtgtac ctagggcagg gccaggtcct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 2160 gtgtgtgtgt gagagagaga gagagagaga gagagagaca gagagagaga tagagagaaa 2220 cataaaggtg atcggcactc agacatcctg tgtggtccac ctcacttctc aagcaggtgt 2280 ctttccagtc tacaactcgt tgaccacagg tggaattcat aagctctgtt ccctgtcctg 2340 cttgggtcct ccagagaaag aaatgttgaa ttatcatctt ggtgatggtc aactctgaaa 2400 gcctaaattt tcatgatcac caaagtgttt ggatttaaaa gggtggctca ctccgtaatt 2460 ccggcacttt gggaggctga ggcagaagga tcacttgagc ccagaagttt cagactaggc 2520 tgggcaacaa agcaagaccc ggtctctccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2580 tcaaaaaaat tagctggggg tggtggtgtg ctcctatagc tccagctact caggaggctg 2640 aggcgggagg atcgcttgag cccaggggtt tgcggctgca gtgagctgtg attgcaccac 2700 tgcactccag cctgggcgac tgtgagaccc cgtctttaag aaaaaaaaaa aaaaaaa 2757 <210> SEQ ID NO 14 <211> LENGTH: 2444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 14 ggtttttttt ttttaccccc cttttttatt tattattttt ttgcacattg agcggatcct 60 tgggaacgag agaaaaaaga aacccaaact cacgcgtgca gaagatctcc ccccccttcc 120 cctcccctcc tccctctttt cccctcccca ggagaaaaag acccccaagc agaaaaaagt 180 tcaccttgga ctcgtctttt tcttgcaata ttttttgggg gggcaaaact ttgagggggt 240 gatttttttt ggcttttctt cctccttcat ttttcttcca aaattgctgc tggtgggtga 300 aaaaaaaatg ccgcagctga acggcggtgg aggggatgac ctaggcgcca acgacgaact 360 gatttccttc aaagacgagg gcgaacagga ggagaagagc tccgaaaact cctcggcaga 420 gagggattta gctgatgtca aatcgtctct agtcaatgaa tcagaaacga atcaaaacag 480 ctcctccgat tccgaggcgg aaagacggcc tccgcctcgc tccgaaagtt tccgagacaa 540 atcccgggaa agtttggaag aagcggccaa gaggcaagat ggagggctct ttaaggggcc 600 accgtatccc ggctacccct tcatcatgat ccccgacctg acgagcccct acctccccaa 660 cggatcgctc tcgcccaccg cccgaaccta tctccagatg aaatggccac tgcttgatgt 720 ccaggcaggg agcctccaga gtagacaagc cctcaaggat gcccggtccc catcaccggc 780 acacattgtc tctaacaaag tgccagtggt gcagcaccct caccatgtcc accccctcac 840 gcctcttatc acgtacagca atgaacactt cacgccggga aacccacctc cacacttacc 900 agccgacgta gaccccaaaa caggaatccc acggcctccg caccctccag atatatcccc 960 gtattaccca ctatcgcctg gcaccgtagg acaaatcccc catccgctag gatggttagt 1020 accacagcaa ggtcaaccag tgtacccaat cacgacagga ggattcagac acccctaccc 1080 cacagctctg accgtcaatg cttccgtgtc caggttccct ccccatatgg tcccaccaca 1140 tcatacgcta cacacgacgg gcattccgca tccggccata gtcacaccaa cagtcaaaca 1200 ggaatcgtcc cagagtgatg tcggctcact ccatagttca aagcatcagg actccaaaaa 1260 ggaagaagaa aagaagaagc cccacataaa gaaacctctt aatgcattca tgttgtatat 1320 gaaggaaatg agagcaaagg tcgtagctga gtgcacgttg aaagaaagcg cggccatcaa 1380 ccagatcctt gggcggaggt ggcatgcact gtccagagaa gagcaagcga aatactacga 1440 gctggcccgg aaggagcgac agcttcatat gcaactgtac cccggctggt ccgcgcggga 1500 taactatgga aagaagaaga agaggaaaag ggacaagcag ccgggagaga ccaatgaaca 1560 cagcgaatgt ttcctaaatc cttgcctttc acttcctccg attacagacc tcagcgctcc 1620 taagaaatgc cgagcgcgct ttggccttga tcaacagaat aactggtgcg gcccttgcag 1680 gagaaaaaaa aagtgcgttc gctacataca aggtgaaggc agctgcctca gcccaccctc 1740 ttcagatgga agcttactag attcgcctcc cccctccccg aacctgctag gctcccctcc 1800 ccgagacgcc aagtcacaga ctgagcagac ccagcctctg tcgctgtccc tgaagcccga 1860 ccccctggcc cacctgtcca tgatgcctcc gccacccgcc ctcctgctcg ctgaggccac 1920 ccacaaggcc tccgccctct gtcccaacgg ggccctggac ctgcccccag ccgctttgca 1980 gcctgccgcc ccctcctcat caattgcaca gccgtcgact tcttggttac attcccacag 2040 ctccctggcc gggacccagc cccagccgct gtcgctcgtc accaagtctt tagaatagct 2100 ttagcgtcgt gaaccccgct gctttgttta tggttttgtt tcacttttct taatttgccc 2160 cccaccccca ccttgaaagg ttttgttttg tactctctta attttgtgcc atgtggctac 2220 attagttgat gtttatcgag ttcattggtc aatatttgac ccattcttat ttcaatttct 2280 ccttttaaat atgtagatga gagaagaacc tcatgattgg taccaaaatt tttatcaaca 2340 gctgtttaaa gtctttgtag cgtttaaaaa atatatatat atacataact gttatgtagt 2400 tcggatagct tagttttaaa agactgatta aaaaacaaaa aaaa 2444 <210> SEQ ID NO 15 <211> LENGTH: 1573 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 15 cttccccggt gcagacaccc ggcgaagccc acccggtttt cccagcggca tttccgatga 60 cagcttcggg gctacgtgtc ctgtgctgtc ggagacgcac aggaagcaaa gtttgtgaga 120 agccttgggg gcgactttgc cttgggcacc cgcatttgtg cgtctgcgag gtgcctcggt 180 gtgcgcggag ctagtttccc agtttcccgg gcccctccct tctccgagcc cctctagcga 240 tttgtttagg aaaagtgatg acatgaacta gtagtggaga atcgcagcgc cgctccccgc 300 cctggggagg gaggggagcc ccggagagcc tgccggtggg agctggaagc aggctcccgg 360 ctgagcgccc cagcccgaaa ggcagggtct gggtgcggga agagggctcg gagctgcctt 420 cctgctgcct tggggccgcc cagatgaggg aacagcccga tttgcctggt tctgattctc 480 caggctgtcg tggttgtgga atgcaaacgc cagcacataa tggaaacagg acctgaagac 540 ccttccagca tgccagagga aagttccccc aggcggaccc cgcagagcat tccctaccag 600 gacctccctc acctggtcaa tgcagacgga cagtacctct tctgcaggta ctggaaaccc 660 acaggcacac ccaaggccct catctttgtg tcccatggag ccggagagca cagtggccgc 720 tatgaagagc tggctcggat gctgatgggg ctggacctgc tggtgttcgc ccacgaccat 780 gttggccacg gacagagcga aggggagagg atggtagtgt ctgacttcca cgttttcgtc 840 agggatgtgt tgcagcatgt ggattccatg cagaaagact accctgggct tcctgtcttc 900 cttctgggcc actccatggg aggcgccatc gccatcctca cggccgcaga gaggccgggc 960 cacttcgccg gcatggtact catttcgcct ctggttcttg ccaatcctga atctgcaaca 1020 actttcaagg tccttgctgc gaaagtgctc aaccttgtgc tgccaaactt gtccctcggg 1080 cccatcgact ccagcgtgct ctctcggaat aagacagagg tcgacattta taactcagac 1140 cccctgatct gccgggcagg gctgaaggtg tgcttcggca tccaactgct gaatgccgtc 1200 tcacgggtgg agcgcgccct ccccaagctg actgtgccct tcctgctgct ccagggctct 1260 gccgatcgcc tatgtgacag caaaggggcc tacctgctca tggagttagc caagagccag 1320 gacaagactc tcaagattta tgaaggtgcc taccatgttc tccacaagga gcttcctgaa 1380 gtcaccaact ccgtcttcca tgaaataaac atgtgggtct ctcaaaggac agccacggca 1440 ggaactgcgt ccccaccctg aatgcattgg ccggtgcccg gctcatggtc tgggggatgc 1500 aggcagggga agggcagaga tggcttctca gatatggctt gcaaaaaaaa aaaaaaaaaa 1560 aaaaaaaaaa aaa 1573 <210> SEQ ID NO 16 <211> LENGTH: 1695 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 atgtggttct gcgcgtgtgc ggacggctgt ctgttaactc cgcggtcagt tcccggactg 60 gtggctggtc tgcagggttg acctgcgcaa tgcagaggct gcaggtagtg ctgggccacc 120 tgaggggtcc ggccgattcc ggctggatgc cgcaggccgc gccttgcctg agcggtgccc 180 cgcaggcctc ggccgcggac gtggtggtgg tgcacgggcg gcgcacggcc atctgccggg 240 cgggccgcgg cggcttcaag gacaccaccc ccgacgagct tctctcggca gtcatgaccg 300 cggttctcaa ggacgtgaat ctgaggccgg aacagctggg ggacatctgt gtcggaaatg 360 tgctgcagcc tggggccggg gcaatcatgg cccgaatcgc ccagtttctg agtgacatcc 420 cggagactgt gcctttgtcc actgtcaata gacagtgttc gtcggggcta caggcagtgg 480 ccagcatagc aggtggcatc agaaatgggt cttatgacat tggcatggcc tgtggggtgg 540 agtccatgtc cctggctgac agagggaacc ctggaaatat tacttcgcgc ttgatggaga 600 aggagaaggc cagagattgc ctgattccta tggggataac ctctgagaat gtggctgagc 660 ggtttggcat ttcacgggag aagcaggata cctttgccct ggcttcccag cagaaggcag 720 caagagccca gagcaagggc tgtttccaag ctgagattgt gcctgtgacc accacggtcc 780 atgatgacaa gggcaccaag aggagcatca ctgtgaccca ggatgagggt atccgcccca 840 gcaccaccat ggagggcctg gccaaactga agcctgcctt caagaaagat ggttctacca 900 cagctggaaa ctctagccag gtgagtgatg gggcagctgc catcctgctg gcccggaggt 960 ccaaggcaga agagttgggc cttcccatcc ttggggtcct gaggtcttat gcagtggttg 1020 gggtcccacc tgacatcatg ggcattggac ctgcctatgc catcccagta gctttgcaaa 1080

aagcagggct gacagtgagt gacgtggaca tcttcgagat caatgaggcc tttgcaagcc 1140 aggctgccta ctgtgtggag aagctacgac tcccccctga gaaggtgaac cccctggggg 1200 gtgcagtggc cttagggcac ccactgggct gcactggggc acgacaggtc atcacgctgc 1260 tcaatgagct gaagcgccgt gggaagaggg catacggagt ggtgtccatg tgcatcggga 1320 ctggaatggg agccgctgcc gtctttgaat accctgggaa ctgagtgagg tcccaggctg 1380 gaggcgctac gcagacagtc ctgctgctct agcagcaagg cagtaacacc acaaaagcaa 1440 aaccacatgg gaaaactcag cactggtggt ggtggcagtg gacagatcaa ggcacttcaa 1500 ctcatttgga aaatgtgaac actgatgaca tggtatagga gtgggtgggg tgttgagcca 1560 cccatcagac cctctttagc tgtgcaagat aaaagcagcc tgggtcaccc aggccacaag 1620 gccatggtta attcttaagg caaggcaaat ccatggatga gaagtgcaat gggcatagta 1680 aaagtgcatg aattt 1695 <210> SEQ ID NO 17 <211> LENGTH: 1936 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 ctggagtttg cggagggccg agccgggtgc gcacggggag gcggaggcag cggcggcggc 60 ggcggcggcg gcggcggcgg agcagatgaa gaaactgagg ccctgtgatg tgaagtgact 120 tgccccccag ccacacagct ggaccattct ggctgctgtc tggacaagaa gtcgtagggg 180 gtgagggtgg aagctgggaa acccacagga ggcaaccaca ctagtttaga tcttctggtg 240 accccacttc tcgctgctca tgccgctggg actggggcgg cggaaaaagg cgccccctct 300 agtggaaaat gaggaggctg agccaggccg tggagggctg ggcgtggggg agccagggcc 360 tctgggcgga ggtgggtcgg ggggccccca aatgggcttg cccccccctc ccccagccct 420 gcggccccgc ctcgtgttcc acacccagct ggcccatggc agtcccactg gccgcatcga 480 gggcttcacc aacgtcaagg agctgtatgg caagatcgcc gaggccttcc gcctgccaac 540 tgccgaggtg atgttctgca ccctgaacac ccacaaagtg gacatggaca agctcctggg 600 gggccagatc gggctggagg acttcatctt cgcccacgtg aaggggcagc gcaaggaggt 660 ggaggtgttc aagtcggagg atgcactcgg gctcaccatc acggacaacg gggctggcta 720 cgccttcatc aagcgcatca aggagggcag cgtgatcgac cacatccacc tcatcagcgt 780 gggcgacatg atcgaggcca ttaacgggca gagcctgctg ggctgccggc actacgaggt 840 ggcccggctg ctcaaggagc tgccccgagg ccgtaccttc acgctgaagc tcacggagcc 900 tcgcaaggcc ttcgacatga tcagccagcg ttcagcgggt ggccgccctg gctctggccc 960 acaactgggc actggccgag ggaccctgcg gctccgatcc cggggccccg ccacggtgga 1020 ggatctgccc tctgcctttg aagagaaggc cattgagaag gtggatgacc tgctggagag 1080 ttacatgggt atcagggaca cggagctggc ggccaccatg gtggagctgg gaaaggacaa 1140 aaggaacccg gatgagctgg ccgaggccct ggacgaacgg ctgggtgact ttgccttccc 1200 tgacgagttc gtctttgacg tctggggcgc cattggggac gccaaggtcg gccgctacta 1260 ggactgcccc cggaccctgc gatgatgacc cgggcgcaac ctggtggggg cccccagcag 1320 ggacactgac gtcaggaccc gagcctccag cctgagccta gctcagcagc ccaaggacga 1380 tggtgagggg aggtggggcc aggccccctg ccccgctcca atcggtacca tcccctccct 1440 ggttcccagt ctggccgggg tccccggccc ccctgtgccc tgttccccac ctacctcagc 1500 tgggtcaggc acagggaggg gagggatcag ccaaattggg cggccacccc cgcctccacc 1560 actttccacc atcagctgcc aaactggtcc ctctgtctcc ctggggcctt gggttctgtt 1620 tgggggtcat gaccttccta gtttcctgac gcagggaata caggggagag ggttgtcctt 1680 ccccccagca aatgcaataa tgccctcacc cctcctgaga ggagccccct ccctgtggag 1740 cctgttacct ccgcatttga cacgagtctg ctgtgaaccc cgcaacctcc tccccacctc 1800 ccatctctcc ttccaggccc atccctggcc cagagcagga gggagggagg gacgatggcg 1860 gtgggttttt gtatctgaat ttgctgtctt gaacataaag aatctatctg ctgttaaaaa 1920 aaaaaaaaaa aaaaaa 1936 <210> SEQ ID NO 18 <211> LENGTH: 2318 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 gccacgaagg ccacagacgc cttccccctt ggactctcat tcccttttcc acggagcccc 60 gcgctttcgt gagccccctc gaggaacctg gtctccgcat ccagttacca cctcctgcct 120 cagaggccat ctgagccctt cgcacctcgc ccctcagtcc ccccttgccc ccccgcggag 180 atcgcctcgc tccctcccgc ccccccatca tcccttccct cgcagttccc ctgtcctgag 240 gggagccccg ccacggcagc gacagcgggc aggagggaga aagtgaaggt tgggcgacac 300 ttggcctcac tcccggctag gcgcacccac ggggaggaga ggaggagccg agagagctga 360 gcagcgcgga agtagctgct gctggtggtg acaatgtcaa ataacggcct agacattcaa 420 gacaaacccc cagcccctcc gatgagaaat accagcacta tgattggagt cggcagcaaa 480 gatgctggaa ccctaaacca tggttctaaa cctctgcctc caaacccaga ggagaagaaa 540 aagaaggacc gattttaccg atccatttta cctggagata aaacaaataa aaagaaagag 600 aaagagcggc cagagatttc tctcccttca gattttgaac acacaattca tgtcggtttt 660 gatgctgtca caggggagtt tacgggaatg ccagagcagt gggcccgctt gcttcagaca 720 tcaaatatca ctaagtcgga gcagaagaaa aacccgcagg ctgttctgga tgtgttggag 780 ttttacaact cgaagaagac atccaacagc cagaaataca tgagctttac agataagtca 840 gctgaggatt acaattcttc taatgccttg aatgtgaagg ctgtgtctga gactcctgca 900 gtgccaccag tttcagaaga tgaggatgat gatgatgatg atgctacccc accaccagtg 960 attgctccac gcccagagca cacaaaatct gtatacacac ggtctgtgat tgaaccactt 1020 cctgtcactc caactcggga cgtggctaca tctcccattt cacctactga aaataacacc 1080 actccaccag atgctttgac ccggaatact gagaagcaga agaagaagcc taaaatgtct 1140 gatgaggaga tcttggagaa attacgaagc atagtgagtg tgggcgatcc taagaagaaa 1200 tatacacggt ttgagaagat tggacaaggt gcttcaggca ccgtgtacac agcaatggat 1260 gtggccacag gacaggaggt ggccattaag cagatgaatc ttcagcagca gcccaagaaa 1320 gagctgatta ttaatgagat cctggtcatg agggaaaaca agaacccaaa cattgtgaat 1380 tacttggaca gttacctcgt gggagatgag ctgtgggttg ttatggaata cttggctgga 1440 ggctccttga cagatgtggt gacagaaact tgcatggatg aaggccaaat tgcagctgtg 1500 tgccgtgagt gtctgcaggc tctggagttc ttgcattcga accaggtcat tcacagagac 1560 atcaagagtg acaatattct gttgggaatg gatggctctg tcaagctaac tgactttgga 1620 ttctgtgcac agataacccc agagcagagc aaacggagca ccatggtagg aaccccatac 1680 tggatggcac cagaggttgt gacacgaaag gcctatgggc ccaaggttga catctggtcc 1740 ctgggcatca tggccatcga aatgattgaa ggggagcctc catacctcaa tgaaaaccct 1800 ctgagagcct tgtacctcat tgccaccaat gggaccccag aacttcagaa cccagagaag 1860 ctgtcagcta tcttccggga ctttctgaac cgctgtctcg atatggatgt ggagaagaga 1920 ggttcagcta aagagctgct acagcatcaa ttcctgaaga ttgccaagcc cctctccagc 1980 ctcactccac tgattgctgc agctaaggag gcaacaaaga acaatcacta aaaccacact 2040 caccccagcc tcattgtgcc aagctctgtg agataaatgc acatttcaga aattccaact 2100 cctgatgccc tcttctcctt gccttgcttc tcccatttcc tgatctagca ctcctcaaga 2160 ctttgatcct tggaaaccgt gtgtccagca ttgaagagaa ctgcaactga atgactaatc 2220 agatgatggc catttctaaa taaggaattt cctcccaatt catggatatg agggtggttt 2280 atgattaagg gtttatataa ataaatgttt ctagtctt 2318 <210> SEQ ID NO 19 <211> LENGTH: 571 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 19 tcagccggac accagaagac aagcagagag actcctccag acccactcag accacgtgca 60 cgccctccaa gatggtatcc cgtaaggctg tggctgctct gctggtggtg catgtagctg 120 ccatgctggc ctcccagacg gaagccttcg tccccatctt cacctatggc gaactccaga 180 ggatgcagga aaaggaacgg aataaagggc aaaagaaatc cctgagtgta tggcagaggt 240 ctggggagga aggtcctgta gaccctgcgg agcccatcag ggaagaagaa aacgaaatga 300 tcaagctgac tgctcctctg gaaattggaa tgaggatgaa ctccagacag ctggaaaagt 360 acccggccac cctggaaggg ctgctgagtg agatgcttcc ccagcatgca gccaagtgat 420 ggccacgctg gggagaaggt ggacagattt gggaggcccc tcctgcccaa gtgaggccct 480 gggaatttac agagcctgcc agctgggctt ggaaggaaaa cacctttcca aagcaaattc 540 ccctccagca aataaagcat gaaatataca g 571 <210> SEQ ID NO 20 <211> LENGTH: 3139 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 ggccgaggag gaagtggcgg cggcggcggc gggactgcgc gccccagctc cgatccccgt 60 tccgcgtccc cgccgccggg aggaggtgcc cactcgctcg cggcgcgcgc cggccgccag 120 actcggcctg tgggcgattt cctccggacc caggctcccc gcccgaggag gaagatgcag 180 acctttctga aagggaagag agttggctac tggctgagcg agaagaaaat caagaagctg 240 aatttccagg ccttcgccga gctgtgcagg aagcgaggga tggaggttgt gcagctgaac 300 cttagccggc cgatcgagga gcagggcccc ctggacgtca tcatccacaa gctgactgac 360 gtcatccttg aagccgacca gaatgatagc cagtccctgg agctggtgca caggttccag 420 gagtacatcg atgcccaccc tgagaccatc gtcctggacc cgctccctgc catcagaacc 480 ctgcttgacc gctccaagtc ctatgagctc atccggaaga ttgaggccta catggaagac 540 gacaggatct gctcgccacc cttcatggag ctcacgagcc tgtgcgggga tgacaccatg 600 cggctgctgg agaagaacgg cttgactttc ccattcattt gcaaaaccag agtggctcat 660 ggcaccaact ctcacgagat ggctatcgtg ttcaaccagg agggcctgaa cgccatccag 720 ccaccctgcg tggtccagaa tttcatcaac cacaacgccg tcctgtacaa ggtgttcgtg 780 gttggcgagt cctacaccgt ggtccagagg ccctcactca agaacttctc cgcaggcaca 840 tcagaccgtg agtccatctt cttcaacagc cacaacgtgt caaagccgga gtcgtcatcg 900 gtcctgacgg agctggacaa gatcgagggc gtgttcgagc ggccgagcga cgaggtcatc 960 cgggagctct cccgggccct gcggcaggca ctgggcgtgt cactcttcgg catcgacatc 1020

atcatcaaca accagacagg gcagcacgcc gtcattgaca tcaatgcctt cccaggctac 1080 gagggcgtga gcgagttctt cacagacctc ctgaaccaca tcgccactgt cctgcagggc 1140 cagagcacag ccatggcagc cacaggggac gtggccctgc tgaggcacag caagcttctg 1200 gccgagccgg cgggcggcct ggtgggcgag cggacatgca gcgccagccc cggctgctgc 1260 ggcagcatga tgggccagga cgcgccctgg aaggctgagg ccgacgcggg cggcaccgcc 1320 aagctgccgc accagagact cggctgcaac gccggcgtgt cgcccagctt ccagcagcat 1380 tgtgtggcct ccctggccac caaggcctcc tcccagtagc cacggagccg ggacccagag 1440 gggcagcgca gggcgcagag cacacccgct gggccagcag ctcccaacgg cgatgctact 1500 actaagaatc cccagtgatc tgattcttct gttttttaat ttttaacctg attctctgat 1560 gtcatgatct aaatgagggg tagtggggga tggaagagag taccaggtgg tccaccgttg 1620 gggagtgggg ccgtccgcct gctctctact gtgcagacct cctaactgag tttacacacg 1680 cttgtgtttg caacactagg tctggatggg aggtgagggg tgtgcgtatg gctgccatgc 1740 cggtgtctgt gcacatccct gtctgttggt ctccatggcc actgtggacc gggacccttg 1800 ggggaagcct gcccatgtcg ggctgtggga ggctgatcgg tgcatgtgag agtggcttcc 1860 cttctgcctg actccccact ccctgacctg ccccttcctt gtttttcctc ctactggtct 1920 ccaccaaggc tttgttagcc cccaccctgc ctggtgtgca gctaacccct ccctccccac 1980 agccagagga ggccacagac ccctcagggg agttccgcgc tggtgtctgg gctgtgctcc 2040 ctcactaaag ggaaggaaag gaagctgggc gtcctctggg ccccccaaca cacgtcccat 2100 ttagccctgc acagcggtct ccttccccta agccagcact gctgctccct ggagcccggg 2160 aaggaggctg cctggctgga ggcccgagcc gatggcgcct gtgctgagga tttgtgctgt 2220 gatttgggca aatcattcca ggtctttggg cctccacccc cttgtctcta gtggacattt 2280 gagatcagag agcaccacag ggctggcttt gtgccctaac ccctgggatg cagcctgcct 2340 ttccataaag tcacctaggt gaggataggc gcgggagcct cggcatgaca ccatggagat 2400 cggggccctc ttcccagtgg gttcactcct tttcacacct gctgggtccc tcctcaccca 2460 gcaggcctgg tccacctctc attgcaagcc ccaagcactg agccagcagg tgccagggag 2520 ccacccgccc cccatcgctt ctgcacacct cagactcacc ccatcacctt ggcagcaaag 2580 cactggctct gccgtctgac ccctgatcca ggcagccccc tctgcagaga aaagggttgg 2640 ggagaagcct ctgcagtcct ggaagatgtg gggtgctggg tgagaggcat cagcccccac 2700 aagtatgttt ttgtgtctta agatagcagt ttactttgaa aaagtgaaaa aggcttccgg 2760 gctgtcctct gcccagtgag atggaggacg ctagagaaag tgctgagtgt cccgagagag 2820 gcccccgagc cagtgcatgg aggtccttcg gcctggctca gctgggctgc aggatgccca 2880 ctttgaggag ggaggcacag ggcttgggcg aggggcagag gccatcagaa ctgcccggct 2940 tttttggaaa ctgaggaccc aacaactaac cacgtttaca cgacttgagt tttgaacccc 3000 gattaatgtc tgtacgtcac ctttcctagt tctgaccctg agccctgggg aacaggaaag 3060 cgtggctggc ctcttgcact gctttgtctc caaaataaac tactgaaatc aaaccgcaaa 3120 aaaaaaaaaa aaaaaaaaa 3139 <210> SEQ ID NO 21 <211> LENGTH: 3590 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 aaaatcagaa gagtggacac tggcaagagg agggcagcct ttttcccagc ttccttgcac 60 catggacagc tcccattaag ccacctctcc atcctggggc caggactctt atgccccatt 120 cctgtcaaat tgagatttca tccaccattc tccaaggaca gtgaagttat accctagttc 180 cagtgttggg atcagtggcc cctctggaca tgcctctcct ggaaggttct gtgggggtgg 240 aggatcttgt cctcctggaa cccttggtgg aggagtcact gctcaagaat cttcagcttc 300 gctatgaaaa caaggagatt tatacctaca ttgggaatgt ggtgatctca gtgaatccct 360 atcaacagct tcccatctat gggccagagt tcattgccaa atatcaagac tatactttct 420 atgagctgaa gccccatatc tacgcattgg caaatgtggc gtaccagtca ctgagggaca 480 gggaccgaga ccagtgtatc ctcatcacag gcgagagtgg atcagggaag actgaggcca 540 gcaagctggt gatgtcttat gtggctgccg tctgtgggaa aggagagcag gtgaactctg 600 tgaaggagca gctgctacag tctaacccag tgctggaggc ttttggcaat gccaagacca 660 ttcgcaacaa caattcctcc cgatttggaa aatacatgga tattgaattt gacttcaagg 720 gatcccccct cggtggtgtc atcacaaact atctgcttga gaaatcccga ttagtgaagc 780 agctcaaagg agaaaggaac ttccacatct tctatcagct gctggctgga gcagatgaac 840 agctgctgaa ggccctgaag cttgagcggg atacaactgg ctatgcctat ctgaatcatg 900 aagtatccag agtggatggc atggacgacg cctccagctt cagggctgta cagagtgcaa 960 tggcagtgat tgggttctcg gaggaggaga ttcgacaagt gctagaggtg acatccatgg 1020 tgctaaagct ggggaacgtg ttggtggctg atgagttcca ggccagtggg ataccagcaa 1080 gtggcatccg tgatgggaga ggtgttcggg agattgggga gatggtgggc ttgaattcag 1140 aagaagtaga gagagctttg tgctcgagga ccatggaaac agccaaggaa aaggtggtca 1200 ctgcactgaa tgttatgcag gctcagtatg ctcgggacgc cctggctaag aacatctaca 1260 gccgcctctt tgactggata gtgaatcgaa tcaatgagag catcaaggtg ggcatcgggg 1320 aaaagaagaa ggtaatggga gtccttgata tctacggttt tgagatatta gaggataata 1380 gctttgagca atttgtgatc aactactgca atgagaagct gcagcaggtg ttcatagaga 1440 tgaccctgaa agaagagcaa gaggaatata agagagaagg cataccgtgg acaaaggtgg 1500 actactttga taatggcatc atttgtaagc tcattgagca taatcagcga ggtatcctgg 1560 ccatgttgga tgaggagtgc ctgcggcctg gggtggtcag tgactccact ttcctagcaa 1620 agctgaacca gctcttctcc aagcatggcc actacgagag caaagtcacc cagaatgccc 1680 agcgtcagta tgaccacacc atgggcctca gctgcttccg catctgccac tatgcgggca 1740 aggtgacata caacgtgacc agctttattg acaagaataa tgacctactc ttccgagacc 1800 tgttgcaggc catgtggaag gcccagcacc ccctccttcg gtccttgttt cctgagggca 1860 atcctaagca ggcatctctc aaacgccccc cgactgctgg ggcccagttc aagagttctg 1920 tggccatcct catgaagaat ctgtattcca agagccccaa ctacatcagg tgcataaagc 1980 ccaatgagca tcagcagcga ggtcagttct cttcagacct ggtggcaacc caggctcggt 2040 acctgggact gctggagaac gtacgggtgc gacgggcagg ctatgcccac cgccagggtt 2100 atgggccctt cctggaaagg taccgattgc tgagccggag cacctggcct cactggaatg 2160 ggggagaccg ggaaggtgtt gagaaggtcc tgggggagct gagcatgtcc tcgggggagc 2220 tggcctttgg caagacaaag atcttcatta gaagccccaa gactcttttc tacctcgaag 2280 aacagaggcg cctgagactc cagcagctgg ccacactcat acagaagatt taccgaggct 2340 ggcgctgccg cacccactac caactgatgc gaaagagtca gatcctcatc tcctcttggt 2400 ttcggggaaa catgcaaaag aaatgctatg ggaagataaa ggcatccgtg ttattgatcc 2460 aggcttttgt gagagggtgg aaggcccgaa agaattatcg caaatatttc cggtcagagg 2520 ctgccctcac cttggcagat ttcatctaca agagcatggt acagaaattc ctactggggc 2580 tgaagaacaa tttgccatcc acaaacgtct tagacaagac atggccagcc gccccctaca 2640 agtgcctcag cacagcaaat caggagctgc agcagctctt ctaccagtgg aagtgcaaga 2700 ggttccggga tcagctgtcc ccgaagcagg tagagatcct gagggaaaag ctctgtgcca 2760 gtgaactgtt caagggcaag aaggcttcat atccccagag tgtccccatt ccattctgtg 2820 gtgactacat tgggctgcaa gggaacccca agctgcagaa gctgaaaggc ggggaggagg 2880 ggcctgttct gatggcagag gccgtgaaga aggtcaatcg tggcaatggc aagacttctt 2940 ctcggattct cctcctgacc aagggccatg tgattctcac agacaccaag aagtcccagg 3000 ccaaaattgt cattgggcta gacaatgtgg ctggggtgtc agtcaccagc ctcaaggatg 3060 ggctctttag cttgcatctg agtgagatgt catcggtggg ctccaagggg gacttcctgc 3120 tggtcagcga gcatgtgatt gaactgctga ccaaaatgta ccgggctgtg ctggatgcca 3180 cgcagaggca gcttacagtc accgtgactg agaagttctc agtgaggttc aaggagaaca 3240 gtgtggctgt caaggtcgtc cagggccctg caggtggtga caacagcaag ctacgctaca 3300 aaaaaaaggg gagtcattgc ttggaggtga ctgtgcagtg aggagggggc accatgcaga 3360 gatggcagtt gcttcctcct gaaccagcac taatccccct ctgccctcct gtgtgggagg 3420 atctctaacc cctctgatcg tggcgcatgg cttggggatt aaactaccct tgaagaggac 3480 ccttgtccca aacccttctt gttctctcct ccaaaagtag cttcctccaa cccgcagcct 3540 ctctgcacac taataaaaca tgtggcttgg aaaggtccaa aaaaaaaaaa 3590 <210> SEQ ID NO 22 <211> LENGTH: 3008 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 taagaatgtc ttttccacct catttgaatc gccctcccat gggaatccca gcactcccac 60 cagggatccc acccccgcag tttccaggat ttcctccacc tgtacctcca gggaccccaa 120 tgattcctgt accaatgagc attatggctc ctgctccaac tgtcttagta cccactgtgt 180 ctatggttgg aaagcatttg ggcgcaagaa aggatcatcc aggcttaaag gctaaagaaa 240 atgatgaaaa ttgtggtcct actaccactg tttttgttgg caacatttcc gagaaagctt 300 cagacatgct tataagacaa ctcttagctc cttcggattc tgtgagtaca aggagccaga 360 atctaccctc cgtgcactca gattattaca tgacctgcaa attggagaga aaaagctact 420 cgttaaagtt gatgcaaaga caaaggcaca gctggatgaa tggaaagcaa agaagaaagc 480 ttctaatggg gttgggatga aagtagtaag ggaggctgga caaggttaac ttgccagaga 540 aagcactggt acagactatt ccaaacagag ctaattcatt aaggcagctt tgtaaaatgc 600 aaggccagaa actgtcacta atgacgatga agaagccttg gatgaagaaa caaagaggag 660 agatcagatg attaaagggg ctattgaagt tttaattcgt gaatactcca gtgagctaaa 720 tgccccctca caggaatctg attctcaccc caggaagaag aagaaggaaa agaaggagga 780 cattttccgc agatttccag tggccccact gatcccttat ccactcatca ctaaggagga 840 tataaatgct atagaaatgg aagaagacaa aagagacctg atatctcgag agatcagcaa 900 attcagagac acacataaga aactggaaga agagaaaggc aaaaaggaaa aagaaagaca 960 ggaaattgag aaagaacgga gagaaagaga gagggagcgt gaaagggaac gagaaaggcg 1020 agaacgggaa cgagaaaggg aaagagaacg tgaacgagaa aaggagaaag aacgggagcg 1080 ggaacgagaa cgggataggg accgtgaccg gacaaaagag agagaccgag atcgggatcg 1140 agagagagat cgtgaccggg atagagaaag gagctcagat cgtaataagg atcgcagtcg 1200 atcaagagaa aaaagcagag atcgtgaaag ggaacgagag cgggaaagag agagagagag 1260

agaacgagag cgagaacgag aacgggagcg agagagagag cgagagaggg aacgggagcg 1320 agaaagagaa aaagacaaaa aacgggaccg agaagaagat gaagaagatg catacgaacg 1380 aagaaaactt gaaagaaaac tccgagagaa agaagctgct tatcaagagc gccttaagaa 1440 ttgggaaatc agagaacgaa agaaaacccg ggaatatgag aaagaagctg aaagagaaga 1500 agaaagaaga agagaaatgg ccaaagaagc taaacgacta aaagaattct tagaagacta 1560 tgatgatgat agagatgacc ccaaatatta cagaggaagt gctcttcaga aaaggttgcg 1620 tgatagagaa aaggaaatgg aagcagatga acgagatagg aagagagaga aggaggagct 1680 tgaggaaatc aggcagcgcc ttctggcaga agggcatcca gatccagatg cagagctcca 1740 gaggatggaa caagaggctg agaggcgcag gcagccacaa ataaagcaag agccagaatc 1800 agaagaggag gaagaagaaa agcaagaaaa agaagaaaaa cgagaagaac ccatggaaga 1860 ggaagaggag ccagagcaaa agccttgtct gaaacctact ctgaggccca tcagctctgc 1920 tccatctgtt tcctctgcca gtggcaatgc aacacctaac actcctgggg atgagtctcc 1980 ctgtggtatt attattcctc atgaaaactc accagatcaa cagcaacctg aggagcatag 2040 gccaaaaata ggactaagtc ttaaactggg tgcttccaat agtcctggtc agcctaattc 2100 tgtgaagaga aagaaactac ctgtagatag tgtctttaac aaatttgagg atgaagacag 2160 tgatgacgta ccccgaaaaa ggaaactggt tcccttggat tatggtgaag atgataaaaa 2220 tgcaaccaaa ggcactgtaa acactgaaga aaagcgtaaa cacattaaga gtctcattga 2280 gaaaatccct acagccaaac ctgagctctt cgcttatccc ctggattggt ctattgtgga 2340 ttctatactg atggaacgtc gaattagacc atggattaat aagaaaatca tagaatatat 2400 aggtgaagaa gaagctacat tagttgattt tgtttgttct aaggttatgg ctcatagttc 2460 accccagagc attttagatg atgttgccat ggtacttgat gaagaagcag aagtttttat 2520 agtcaaaatg tggagattat tgatatatga aacagaagcc aagaaaattg gtcttgtgaa 2580 gtaaaacttt ttatatttag agttccattt cagatttctt ctttgccacc cttttaagga 2640 ctttgaattt ttctttgtct ttgaagacat tgtgagatct gtaatttttt ttttttgtag 2700 aaaatgtgaa ttttttggtc ctctaatttg ttgttgccct gtgtactccc ttggttgtaa 2760 agtcatctga atccttggtt ctctttatac tcaccaggta caaattactg gtatgtttta 2820 taagccgcag ctactgtaca cagcctatct gatataatct tgttctgctg atttgtttct 2880 tgtaaatatt aaaacgactc cccaattatt ttgcagaatt gcacttaata ttgaaatgta 2940 ctgtatagga accaacatga acaattttaa ttgaaaacac cagtcataaa ctattaccac 3000 ccccactc 3008 <210> SEQ ID NO 23 <211> LENGTH: 4540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 23 attctggggt tcgtttagag gtttgaattt tctcggagaa agacaggccg gccacgagga 60 aaacagaaac aagccgcagc aacatctaag cccttgaaag gatcctgaga gaggggggaa 120 agggaaaaca gcagccacca gcccaaccac ttgtgtcttc tgccccttcc cacctatctt 180 gcccacccca ccagcccacg ctgcttggga cttgaaatct gtggccgaag gaccgtcact 240 acataacttc aaaaataatc aaccaccctc ccttcccaaa ccacccaaat tcactcatcc 300 agcgtttact tttttgaatc cactcagaac ttttttctgc gacccccctc cctaaatgga 360 gttgggtggg ggggaaatga atactgagtt ggcctttatt ttttaaaaga ctttttgatc 420 caatgaggcc ccctaaataa ttgagttttg ggtcctggtt ggttgtttta ttttttttcc 480 tccaaaattt taccccctcc cccctgagcc cgaggtgctg acgtcgcaaa aaaattggat 540 aaaaccacca tcatgggttc gggtcccata gaccccaaag aacttctcaa gggcctggac 600 agcttcctta accgagatgg ggaagtcaaa agtgtggatg ggatttccaa gatcttcagt 660 ttgatgaagg aagcacgaaa gatggtgagt cgatgcactt acttgaacat tctcctgcag 720 acccgttcac cagaaatatt ggtcaaattt attgacgttg gcggctacaa acttcttaac 780 aattggctga cgtattcaaa gacaaccaac aacattcccc tcctccagca aattctactg 840 accctgcagc atctaccgct cactgtagac catctcaagc agaacaacac agctaaactg 900 gtgaagcagc tgagcaagtc aagtgaggat gaagagctcc ggaaattggc ctcagtcctt 960 gtcagcgact ggatggctgt catccgctct cagagcagta cccagcctgc tgagaaagat 1020 aagaagaaac gtaaagatga aggaaaaagt cgaactaccc ttcctgagcg acctttgaca 1080 gaggtgaagg ctgagacccg ggctgaggag gccccagaga agaagaggga gaagcccaag 1140 tctcttcgca ccacagcacc cagtcatgcc aagttccgtt ccactggact agagctggag 1200 acaccatcct tggtgcctgt gaagaagaat gccagcacag tggtggtttc tgacaagtac 1260 aaccttaaac ccatccccct caaacgtcag agcaacgtag ctgctccagg agatgccact 1320 ccccctgcag agaagaaata caagccactc aacacaacac ctaatgccac caaagagatc 1380 aaagtgaaga tcatcccgcc acagcctatg gagggcctgg gctttctgga tgctcttaat 1440 tcagcccctg ttccaggcat caaaattaag aagaaaaaaa aagtactgtc acctacggct 1500 gccaagccaa gcccctttga agggaaaacg agcacagaac caagcacagc caaaccttct 1560 tccccagaac cagcaccacc ttctgaggca atggacgcag accgtccagg caccccggtt 1620 ccccctgttg aagtcccgga gctcatggat acagcctctt tggagccagg agctctggat 1680 gccaagccag tggagagtcc tggagatcct aaccaactga cccggaaagg caggaagagg 1740 aaaagtgtga catggcctga ggaaggcaaa ctgagagaat atttctattt tgaattggat 1800 gaaactgaac gagtaaatgt gaataagatc aaggactttg gtgaggcggc taagcgagag 1860 atactgtcag accgacatgc atttgagaca gcgcggcgtc tgagccatga taacatggag 1920 gagaaggtgc cctgggtgtg cccccggccc ctggttctgc cctcacctct tgtcacccct 1980 ggaagcaata gtcaggagcg atatatccag gctgagcggg agaagggaat ccttcaggag 2040 ctcttcctga acaaggagag tcctcatgag cctgatcctg agccctacga gcccataccc 2100 cctaaactca tccccctaga tgaggagtgt tccatggatg agactccgta tgttgagact 2160 ctggaacctg gggggtcagg tggctcacct gatggggcag gaggctccaa gttgcctcca 2220 gttctggcca atcttatggg aagcatgggt gctggaaagg gcccccaagg ccctggagga 2280 ggaggcatta atgtccaaga gatcctcacc tccatcatgg gtagcccaaa cagtcatcct 2340 tcagaggaac tactgaaaca accagactat tcggacaaga tcaagcagat gctggtgcca 2400 catggactcc taggccctgg cccaatagcc aatggtttcc caccaggggg tcctgggggc 2460 cccaagggca tgcagcactt tccccctgga cctgggggac ctatgccagg tccccatgga 2520 ggccctggtg ggccagtggg tccacgtctt ctgggtcctc caccccctcc ccggggaggt 2580 gatcccttct gggatggccc gggcgaccct atgcggggtg gcccaatgcg ggggggtcca 2640 ggaccaggtc ctggaccata ccatagaggc cgaggtggcc gaggaggaaa cgaacctcct 2700 cctcctcctc ctccattccg aggcgccaga ggaggtcgct ctggaggagg acccccaaat 2760 ggacgagggg gccctggtgg gggcatggtt ggaggtggtg ggcatcgtcc tcacgaaggc 2820 cctggtgggg gcatgggcaa cagcagtgga catcgtcccc acgaaggccc tggcggtggc 2880 atgggaagtg ggcatcgccc ccatgaaggc cctggtggta gcatgggtgg gggtggagga 2940 catcgtcccc acgaaggccc tggcggtggc atcagtggtg gcagtggcca tcgtccccat 3000 gaaggccctg gcggaggaat gggtgccggt ggtggacatc gcccccacga aggccctggc 3060 ggaagcatgg gtggaagtgg tggacatcgt ccccatgaag gccctggaca cggggggccc 3120 catggccacc ggcctcatga tgtccctggt caccgaggcc atgaccatcg agggccgcca 3180 cctcatgagc accgtggcca tgatggtcct ggccacgggg gagggggcca ccgagggcac 3240 gatggaggcc acagccatgg aggagacatg tcaaaccgcc ctgtctgccg acatttcatg 3300 atgaagggca actgccgcta tgagaacaac tgtgccttct accacccggg tgtcaatggg 3360 ccccccctgc cctagggacc atttgcctgc cctgttcaca caacccctgt ggactgcagc 3420 ctcgctcttt ccaccctgtt atggcttctg tgaggcccat tttccctttt ccccagctga 3480 tgaggagccg gccccctcag ttcccacttg cttgggttcc tgggggtttt ctgatcactg 3540 gtgcgcattg atgtacatat tttcctccag tctggggagg agagagactg gaaacgttcc 3600 tggactgctg aagaggagac ccagttggct tcactttttg agaagattcg ccctgtaccc 3660 caaacccctt tccagtatta cccttaatgc ttgagaacct aaagctggtt atcctggcga 3720 acacccctac ccttctattg cgggtcccca catgcacaca gaactctgac acaggatcag 3780 ctgcacttaa gaaatcatcc cagctaagtt cattattcct catggggtgg ggagatgctg 3840 aaaggggtat tgtatatccc actgcactga gagggctcaa tcagctggat ttgagttctg 3900 gaacacacat catccccacc cctcccccag cgtgggctca ccattcttag tcctttctca 3960 agtgggacct tcaactttct gtgaacaccc agtctgcgtc ctgggtctgc taggttcgat 4020 gatggcgaac tcgtatctgc atccggtgca agttttagct ggcagaggtg agaccggtgg 4080 tgctggtctg cctttgccaa ctatagccag tctggagact tgataaaata cttcagtgag 4140 accagcttct catcaacttg ggcccggcgt gctgggcctg aaagtcacac tacatgcact 4200 gcctttggga gtcagctcac tccctgctcc cacctggaac cttgccagcg tgaaggaggc 4260 ttccaggtac ttcaccctgt caaccacctc tgaatcccca ccaggcgcct tcctgggtgg 4320 attcaacaag atgattttgc cctttcccag ttctctcctt cactttggca tcagttgttt 4380 tctatgaaaa cagtggattg gttgggtttt gtgcagggtc ttgggttaga gccaaaatgg 4440 atttgaggat gagtattttt ttttttggtt ttgtatattt tgtacattaa taataaacag 4500 tggaaagaga agcagcttaa aaaaaaaaaa aaaaaaaaaa 4540 <210> SEQ ID NO 24 <211> LENGTH: 3233 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 tgcgactgag tcggtggcga agacgggaac gcgacgatgg cggagactct gcccgggtcg 60 ggcgactcgg gccctggcac ggcttctctc ggcccgggcg ttgcggagac tgggacgagg 120 cggctcagcg agctgcgggt gatcgatctg cgggcggagc tgaagaagcg gaacctggac 180 acgggcggca acaagagcgt cctgatggag cggctcaaga aggcggttaa agaagagggg 240 caagatcctg atgaaattgg catcgagtta gaagccacca gcaagaagtc agccaagaga 300 tgtgttaaag gactgaagat ggaggaggaa ggcacagaag ataatggcct ggaagacgat 360 tccagagacg ggcaggagga catggaagca agtctggaga acctgcagaa tatgggcatg 420 atggacatga gtgtgctaga cgaaactgaa gtggcgaata gcagtgctcc agattttggg 480 gaggatggca cggacggcct tctcgattcc ttttgtgata gtaaagaata cgtggctgca 540 cagctgagac agctcccggc tcagccccca gagcatgctg tggatgggga aggatttaag 600 aacactttgg aaacttcatc gttgaacttc aaagtaactc cggacattga agaatccctt 660 ttggagccag aaaatgagaa aatactcgac attttggggg aaacttgtaa atctgagcca 720

gtaaaagaag aaagttccga gctggagcag ccatttgcac aggacacaag tagcgtgggg 780 ccagacagaa agcttgcgga ggaagaggac ctatttgaca gcgcccatcc ggaagagggt 840 gatttagatt tggccagcga gtcaacagca cacgctcagt cgagcaaggc agacagcctg 900 ttagcggtag tgaaaaggga gcccgcggag cagccaggcg atggcgagag gacggactgt 960 gagcctgtag ggctagagcc ggcagttgag cagagtagtg cggcctccga gctcgcggag 1020 gcctctagcg aggagctcgc agaagcaccc acggaagccc caagcccaga agccagagat 1080 agcaaagaag acgggaggaa gtttgatttt gacgcttgta atgaagtccc tccggctcct 1140 aaagagtcct caaccagtga gggcgctgat cagaaaatga gctcttttaa ggaagaaaaa 1200 gatataaagc caatcattaa agatgaaaaa ggtcgggtcg gcagcggttc tggtcggaac 1260 ctgtgggtca gcgggctgtc ctccacaaca cgcgctacgg atctcaagaa ccttttcagc 1320 aagtatggga aggttgtcgg ggccaaagtg gtaacgaacg cccgcagccc gggggctcga 1380 tgctatggat tcgtcaccat gtcgacatct gacgaggcga ccaagtgcat cagccatctc 1440 cacagaactg agctgcatgg acgaatgatc tccgtagaga aggccaaaaa tgagcctgct 1500 gggaaaaagc tttccgacag aaaagagtgc gaagtgaaga aggaaaaatt atcgagtgtc 1560 gacagacatc attctgtgga gatcaaaatt gaaaaaactg taattaagaa ggaagagaag 1620 attgagaaga aggaggaaaa aaagcctgaa gacattaaga aggaagaaaa agaccaggat 1680 gagctgaaac ccggacctac aaatcggtct agagtcacca aatcaggaag cagaggaatg 1740 gagcggacgg tcgtgatgga taaatcgaaa ggagagcccg tcattagcgt gaaaaccaca 1800 agcaggtcca aagagagaag ctccaagagt caggatcgca agtcagaaag caaagaaaag 1860 agagacatct tgtcgtttga taaaatcaaa gaacaaaggg agagagagcg ccagaggcag 1920 cgggaacggg agatccgcga aacggagagg cggcgggagc gcgagcagcg ggagcgggag 1980 caacgcctcg aggccttcca tgagcggaag gagaaggccc ggctacagcg ggaacgcctg 2040 cagctcgagt gccagcgcca gcggctggag cgggagcgca tggagcggga gcggctggag 2100 cgcgagcgca tgcgcgtgga gcgtgagcgc aggaaggagc aggagcgcat ccaccgcgag 2160 cgcgaggagc tgcggcgcca gcaggagcag ctgcgttacg agcaggagcg gcggcccggg 2220 cggaggccct acgacctgga ccgacgagat gatgcctatt ggccagaagg aaagcgtgtg 2280 gcaatggagg accgatatcg tgcagacttt ccccggccag accaccgctt tcacgacttc 2340 gatcatcgag accggggcca gtaccaggac cacgccatcg acaggcggga gggttcgagg 2400 ccaatgatgg gagaccaccg ggatgggcag cactatggag atgaccgcca tggccacgga 2460 ggacccccag agcgccacgg ccgggactcc cgtgatggct gggggggcta cggctccgac 2520 aagaggctga gtgaaggccg ggggctgccc cctcccccca ggggtggccg tgactgggga 2580 gagcacaacc agcggctaga ggagcaccag gcacgcgcct ggcagggtgc catggacgca 2640 ggcgcggcta gccgggagca cgccaggtgg caaggtggcg agaggggcct gtctgggccc 2700 tcggggccgg ggcacatggc aagccgcggt ggagtggcgg ggcgaggcgg ctttgcacaa 2760 ggtggacatt cccagggcca cgtggtgcca ggtggcggac tggaaggtgg cggagtggcc 2820 agccaggacc ggggcagcag agtccctcac ccacaccctc atcccccccc gtacccccac 2880 ttcacccgcc gctactaagt cccactcgct gtgagttttc gggtgggcag acgcactgtt 2940 gaatctggta gccagggttc cctcgaactt gggggatctt tttaaaagca aagtaaatcc 3000 tgccaccatg ttgtagctca atacaatgtg aactcacttt tttttttttt tttaataaat 3060 gtgttcttgt tctgccattt ttaaatcaag gtttctgtta acgaggcatt ccattttcca 3120 ttaataaagt ttaccattcg caaaaaaaaa atgtgttctt gttctgccat ttttaaatca 3180 aggtttctgt taacgaggca ttccattttc cattaataaa gtttaccatt cgc 3233 <210> SEQ ID NO 25 <211> LENGTH: 17847 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 25 atgggtgccc cgagcgcgtg ccggacgctg gtgttggctc tggcggccat gctcgtggtg 60 ccgcaggcag agtgcacggg cagatccccc tacgactccc tgagtgtcct ggatgggacc 120 ctacccgtcc ccaacacagg gctctggggc cccacgggct cacagtgtca ggaaactcag 180 gggctggctt ggatggggtg tccaggagaa gagacccagg gccctgtgga gccgagctgg 240 gagaatgcag ggcacaccat ggatggcggt gccccgacgt cctcgcccac ccggcgcgtg 300 agctttgttc cacccgtcac tgtcttcccc agcctgagcc gtaagcagat gctgcccctg 360 ccagccggga agggggtgtt tgccagtccc aaaggtgggg gcccagatct aggggtgcag 420 ctgccaccag ccctgaaccc ggcgcacaat gggcgggtgt gcagcacctg gggtgacttc 480 cactacaaga ccttcgacgg cgacgtcttc cgcttccctg gcctttgcaa ctacgtgttc 540 tctgagcact gccgcgccgc ctacgaggac ttcaacgtcc agctacgccg aggcctagtg 600 ggctccaggc ctgtggtcac ccgtgttgtc atcaaggccc aggggctggt gctggaggcg 660 tccaacggct ccgtcctcat caatgggcag cgggaggagc tgccttacag ccgcactggc 720 ctcctggtgg agcagagcgg ggactacatc aaggtcagca tccggctggt gctgacattc 780 ctgtggaacg gagaggacag tgccctgctg gagctggatc ccaaatacgc caaccagacc 840 tgtggcctgt gtggggactt caacggcctc ccggccttca acgagttcta tgcccacaac 900 gccaggctga ccccgctcca gtttgggaac ctgcagaagt tggatgggcc cacggagcag 960 tgcccggacc cgctgccctt gccggccggc aactgcacgg acgagccccc atggatggca 1020 ggggtgccca gcctggccca ctgtgctccc caggagggca tctgccaccg caccctgctg 1080 gggccggcct ttgcggagtg ccacgcactg gtggacagca ctgcgtacct ggccgcctgc 1140 gcccaggacc tgtgccgctg ccccacctgc ccgtgtgcca cctttgtgga atactcacgc 1200 cagtgcgccc acgcgggggg ccagccgcgg aactggaggt gccctgagct ctgcccccgg 1260 acctgccccc tcaacatgca gcaccaggag tgtggctcac cctgcacgga cacctgctcc 1320 aacccccagc gcgcgcagct ctgcgaggac cactgtgtgg acggctgctt ctgcccccca 1380 ggcacggtgc tggatgacat cacgcactct ggctgcctgc ccctcgggca gtgcccctgc 1440 acccacggcg gccgcaccta cagcccgggc acctccttca acaccacctg cagctcctgc 1500 acctgctccg gggggctatg gcagtgccag gacctgccgt gccctggcac ctgctctgtg 1560 cagggcgggg cccacatctc cacctatgat gagaaactct acgacctgca tggtgactgc 1620 agctacgttc tgtccaagag ccacatcccc cacatgggca tccccagcac acttctgggg 1680 ggcaccccac atcatcgagc caggcccaat gcacgcgtgg gtccttctcc ccagaaatgt 1740 gccgacagca gcttcaccgt gctggctgag ctgcggaagt gcggcctgac ggacaacgag 1800 aactgcctga aagcggtgac gctcagcctg gacggcgggg acacggccat ccgggtccaa 1860 gcggacggcg gcgtgttcct caactccatc tacacgcagc tgcccctgtc ggcagccaac 1920 atcaccctgt tcacaccctc gagcttcttc atcgtggtgc agacaggcct ggggctgcag 1980 ctgctggtgc agctggtgcc actcatgcag gtgtttgtca ggctggaccc cgcccaccag 2040 ggccagatgt gcggcctgtg tgggaacttc aaccagaacc aggctgacga cttcacggcc 2100 ctcagcgggg tggtggaggc cacgggcgca gccttcgcca acacctggaa ggcccaggct 2160 gcctgtgcca atgccaggaa cagctttgag gacccctgct ccctcagtgt ggagaatgag 2220 aactacgccc ggcactggtg ctcgcgcctg accgatccca acagtgcctt ctcgcgctgc 2280 cactccatca tcaaccccaa gcccttccac tcgaactgca tgtttgacac ctgcaactgt 2340 gagcggagcg aggactgcct gtgcgccgcg ctgtcctcct atgtgcacgc ctgtgccgcc 2400 aagggcgtac agctcagcga ctggagggac ggcgtctgca ccaagtacat gcagaactgc 2460 cccaagtccc agcgctacgc ctacgtggtg gatgcctgcc agcccacttg ccgcggcctg 2520 agtgaggccg acgtcacctg cagcgtttcc ttcgtgcctg tggacggctg cacctgcccc 2580 gcgggcacct tcctcaatga cgcgggcgcc tgtgtgcccg cccaggagtg cccctgctac 2640 gctcacggca ccgtgctggc tcctggagag gtggtgcacg acgagggcgc cgtgtggtaa 2700 gggtctgggg ggaaagcagg ccccccaggg tgtgcagccc ccatggtgta cctggactgc 2760 agcaacagct cggcgggcac ccctggggcc gagtgcctcc ggagctgcca cacgctggac 2820 gtgggctgtt tcagcacaca ctgcgtgtcc ggctgtgtct gtcccccggg gctggtgtcg 2880 gatgggagtg ggggctgcat tgccgaggag gactgcccct gtgtgcacaa cgaggccacc 2940 tacaagcctg gagagaccat cagggtcgac tgcaacacct gcacctgcag gaaccggagg 3000 tgggagtgca gccaccggct ctgcctgggc acctgcgtgg cctacgggga tggccacttc 3060 atcacctttg atggcgatcg ctacagcttt gaaggcagct gcgagtacat cttggcccag 3120 gactactgtg gggacaacac cacccacggg accttccgca tcgtcaccga gaacatcccc 3180 tgtgggacca ccggcaccac ctgctccaag gccatcaagc tcttcgtgga ggtgagaacg 3240 gccccagctg tgagcacccc cgaccctgca gccaacgagc cggcccccag ggaagcttcg 3300 gtcggcttcc ggcagcgtct gcctcccctg cagagctacg agctgatcct ccaagagggg 3360 acctttaagg cggtggcgag agggccgggt ggggacccac cctacaagat acgctacatg 3420 gggatcttcc tggtcatcga gacccacggg atggccgtgt cctgggaccg gaagaccagc 3480 gtgttcatcc gactgcacca ggactacaag ggcagggtct gcggcctgtg cgggaacttc 3540 gacgacaatg ccatcaatga ctttgccacg cgtagccggt ccgtggtggg ggacgcactg 3600 gagtttggga acagctggaa gctctccccc tcctgcccgg acgccctggc acccaaggac 3660 ccctgcacgg ccaacccctt ccgcaagtcc tgggcccaga agcagtgcag catcctccac 3720 ggccccacct tcgccgcctg ccgctcccag gttgactcca ccaagtacta cgaggcctgc 3780 gtgaacgacg cgtgtgcctg cgactcgggt ggcgactgcg agtgtttctg cacggctgtg 3840 gctgcctacg cccaggcctg ccacgacgcg ggcctgtgtg tgtcctggcg gactccggac 3900 acctgcccct tgttctgtga cttctacaac ccacatgggg gctgtgagtg gcactaccag 3960 ccctgcgggg caccctgcct aaaaacctgc cggaacccca gtgggcactg cctggtggac 4020 ctgcctggcc tggaaggctg ctacccgaag tgcccaccca gccagccctt cttcaatgag 4080 gaccagatga agtgcgtggc ccagtgtggc tgctacgaca aggacggaaa ctactatgac 4140 gtcggtgcaa gggtccccac agcggagaac tgccagagct gtaactgcac acccagtggc 4200 atccagtgcg ctcacagcct tgaggcctgc acctgcacct atgaggacag gacctacagc 4260 taccaggacg tcatctacaa caccaccgat gggcttggcg cctgcttgat cgccatctgc 4320 ggaagcaacg gcaccatcat caggaaggct gtggcatgtc ctggaactcc agccacaacg 4380 ccattcacct tcaccaccgc ctgggtcccc cactccacga caagcccggc cctcccggtc 4440 tccaccgtgt gtgtccgcga ggtctgccgc tggtccagct ggtacaatgg gcaccgccca 4500 gagcccggcc tgggaggcgg agactttgag acgtttgaaa acctgaggca gagagggtac 4560 caggtatgcc ctgtgctggc tgacatcgag tgccgggcgg cgcagcttcc cgacatgccg 4620 ctggaggagc tgggccagca ggtggactgt gaccgcatgc gggggctgat gtgcgccaac 4680 agccaacaga gtcccccgct ctgtcacgac tacgagctgc gggttctctg ctgcgaatac 4740

gtgccctgtg gcccctcccc ggccccaggc accagccctc agccctccct cagtgccagc 4800 acggagcctg ctgtgcctac cccaacccag accacagcaa ccgaaaagac caccctatgg 4860 gtgaccccga gcatccggtc gacggcggcc ctcacctcgc agactgggtc cagctcaggc 4920 cccgtgacgg tcaccccctc ggccccaggt accaccacct gccagccccg gtgtcagtgg 4980 acagagtggt ttgatgagga ctaccccaag tctgaacaac ttggagggga cgttgagtcc 5040 tacgataaga tcagggccgc tggagggcac ttatgccagc agcctaagga catagagtgc 5100 caggccgaga gcttccccaa ctggaccctg gcacaggtgg ggcagaaggt gcactgtgac 5160 gtccacttcg gcctggtgtg caggaactgg gagcaggagg gcgtcttcaa gatgtgctac 5220 aactacagga tccgggtcct ctgctgcagt gacgaccact gcaggggacg tgccacaacc 5280 ccgccaccga ccacagagct ggagacggcc accaccacca ccacccaggc cctgttctca 5340 acgccgcagc ctacgagtag cccggggctg accagggctc ccccggccag caccacagca 5400 gtccccaccc tctcagaagg actgacatcc cccagataca caagcaccct tggtacagcc 5460 accacgggag gccccacgac gcctgcaggc tccacagaac ccactgtccc aggggtggcc 5520 acatccaccc ttccaacacg ctcagccctt ccagggacga cggggagctt gggcacatgg 5580 cgcccctcac agccacccac gctggcccca acaacaatgg caacctccag agctcgcccg 5640 acaggcacag ccagcaccgc ttccaaagag ccgctgacca cgagcctggc gccaacactc 5700 acgagcgagc tgtccacctc tcaggccgag accagcacgc ccaggacaga gacgacaatg 5760 agccccttga ctaacaccac caccagccag ggcacgaccc gctgtcaacc gaagtgtgag 5820 tggacagagt ggtttgacgt ggacttccca acctcagggg ttgcaggcgg ggacatggaa 5880 acttttgaaa acatcagggc tgctgggggc aagatgtgct gggcaccaaa gagcatagag 5940 tgccgggcgg agaactaccc cgaggtaagc atcgaccagg tcgggcaggt gctgacctgc 6000 agcctggaga cggggctgac ctgcaagaac gaagaccaga caggcaggtt caacatgtgc 6060 ttcaactaca acgtgcgtgt gctttgctgt gacgactaca gccactgccc cagtacccca 6120 gccaccagct ccacggccac gccctcctca actccgggga cgacctggat cctcacaaag 6180 ccgaccacaa cagccactac gactgcgtcc actggatcca cggccacccc gacctccacc 6240 ctgagaacag ctccccctcc caaagtgctg accaccacgg ccaccacacc cacagtcacc 6300 agctccaaag ccactccctc ctccagtcca gggactgcaa ccgcccttcc agcactgaga 6360 agcacagcca ccacacccac agctaccagc gttacaccca tcccctcttc ctccctgggc 6420 accacctgga cccgcctatc acagaccacc acacccacgg ccaccatgtc cacagccaca 6480 ccctcctcca ctccagagac tgcccacacc tccacagtgc ttaccgccac ggccaccaca 6540 actggggcca ccggctctgt ggccaccccc tcctccaccc caggaacagc tcacactacc 6600 aaagtgccaa ctaccacaac cacgggcttc acagccaccc cctcctccag cccagggacg 6660 gcactcacgc ctccagtgtg gatcagcaca accaccacac ccacaaccag aggctccacg 6720 gtgaccccct cctccatccc ggggaccacc cacaccgcca cagtgctgac caccaccacc 6780 acaactgtgg ccactggttc tatggcaaca ccctcctcta gcacacagac cagtggtact 6840 cccccatcac tgaccaccac ggccactacg atcacggcca ccggctccac caccaacccc 6900 tcctcaactc ctgggacaac tcccatcccc ccagtgctga ccaccaccgc caccacacct 6960 gcagccacca gcaacacagt gactccctcc tctgccctag ggaccaccca cacaccccca 7020 gtgccgaaca ccatggccac cacacacggg cgatccctgc cccccagcag tccccacacg 7080 gtgcgcacag cctggacttc ggccacctcg ggcatcttgg gcaccaccca catcacagag 7140 ccttccacgg tgacttccca caccctagca gcaaccaccg gtaccaccca gcactcgact 7200 ccagcccttt ccagccctca ccctagcagc agaaccaccg agtcaccccc ttctccaggg 7260 acgaccaccc cgggccacac cacggccacc tccaggacca cagccacggc cacacccagc 7320 aagacccgca cctcgaccct gctgcccagc agccccacat cggcccccat aaccacggtg 7380 gtgaccatgg gctgtgagcc ccagtgtgcc tggtcagagt ggctggacta cagctacccc 7440 atgccggggc cctctggcgg ggactttgac acctactcca acatccgtgc ggccggaggg 7500 gccgtctgtg agcagcccct gggcctcgag tgccgtgccc aggcccagcc tggtgtcccc 7560 ctgcgggagt tgggccaggt cgtggaatgc agcctggact ttggcctggt ctgcaggaac 7620 cgtgagcagg tggggaagtt caagatgtgc ttcaactatg aaatccgtgt gttctgctgc 7680 aactacggcc actgccccag caccccggcc accagctcta cggccatgcc ctcctccact 7740 ccggggacga cctggatcct cacagagctg accacaacag ccactacgac tgagtccact 7800 ggatccacgg ccaccccgtc ctccacccca gggaccacct ggatcctcac agagccgagc 7860 actacagcca ccgtgacggt gcccaccgga tccacggcca ccgcctcctc cacccaggca 7920 actgctggca ccccacatgt gagcaccacg gccacgacac ccacagtcac cagctccaaa 7980 gccactccct tctccagtcc agggactgca accgcccttc cagcactgag aagcacagcc 8040 accacaccca cagctaccag ctttacagcc atcccctcct cctccctggg caccacctgg 8100 acccgcctat cacagaccac cacacccacg gccaccatgt ccacagccac accctcctcc 8160 actccagaga ctgtccacac ctccacagtg cttaccacca cggccaccac aaccggggcc 8220 accggctctg tggccacccc ctcctccacc ccaggaacag ctcacactac caaagtgctg 8280 actaccacaa ccacgggctt cacagccacc ccctcctcca gcccagggac ggcacgcacg 8340 cttccagtgt ggatcagcac aaccaccaca cccacaacca gaggttccac ggtgaccccc 8400 tcctccatcc cggggaccac ccacaccccc acagtgctga ccaccaccac cacaactgtg 8460 gccactggtt ctatggcaac accctcctct agcacacaga ccagtggtac tcccccatca 8520 ctgaccacca cggccactac gatcacggcc accggctcca ccaccaaccc ctcctcaact 8580 ccagggacaa cacctatccc cccagtgctg accaccaccg ccaccacacc tgcagccacc 8640 agcagcacag tgactccctc ctctgcccta gggaccaccc acacaccccc agtgccgaac 8700 accacggcca ccacacacgg gcgatccctg tcccccagca gtccccacac ggtgcgcaca 8760 gcctggactt cggccacctc aggcaccttg ggcaccaccc acatcacaga gccttccacg 8820 gggacttccc acaccccagc agcaaccacc ggtaccaccc agcactcgac tccagccctg 8880 tccagccctc accctagcag caggaccacc gagtcacccc cttctccagg gacgaccacc 8940 ccgggccaca ccagggccac ctccaggacc acggccacgg ccacacccag caagacccgc 9000 acctcgaccc tgctgcccag cagccccaca tcggccccaa taaccacggt ggtgaccatg 9060 ggctgtgagc cccagtgtgc ctggtcagag tggctggact acagctaccc catgccgggg 9120 ccctctggcg gggactttga cacctactcc aacatccgtg cggccggagg ggccgtctgt 9180 gagcagcccc tgggcctcga gtgccgtgcc caggcccagc ctggtgtccc cctgcgggag 9240 ttgggccagg tcgtggaatg cagcctggac tttggcctgg tctgcaggaa ccgtgagcag 9300 gtggggaagt tcaagatgtg cttcaactat gaaatccgtg tgttctgctg caactacggc 9360 cactgcccca gcaccccggc caccagctct acggccacgc cctcctccac tccagggacg 9420 acctggatcc tcacagagca gaccacagca gccactacga ccgcaaccac tggatccacg 9480 gccatcccgt cctccacccc gggaacagct ccccctccca aagtgctgac cagcacggcc 9540 accacaccca cagccaccag ttccaaagcc acttcctcct ccagtccaag gactgcaacc 9600 acccttccag tgctgacaag cacagccacc aaatccacag ctaccagctt tacacccatc 9660 ccctccttca cccttgggac caccgggacc ctcccagaac agaccaccac acccatggcc 9720 accatgtcca caatccaccc ctcctccact ccggagacca cccacacctc cacagtgctg 9780 accacgaagg ccaccacgac aagggccacc agttccatgt ccaccccctc ctccactccg 9840 gggacgacct ggatcctcac agagctgacc acagcagcca ctacaactgc agccactggc 9900 cccacggcca ccccgtcctc caccccaggg accacctgga tcctcacaga gcccagcact 9960 acagccaccg tgacggtgcc caccggatcc acggccaccg cctcctccac ccgggcaact 10020 gctggcaccc tcaaagtgct gaccagcacg gccaccacac ccacagtcat cagctccaga 10080 gccactccct cctccagtcc agggactgca accgcccttc cagcactgag aagcacagcc 10140 accacaccca cagctaccag cgttacagcc atcccctctt cctccctggg caccgcctgg 10200 acccgcctat cacagaccac cacacccacg gccaccatgt ccacagccac accctcctct 10260 actccagaga ctgtccacac ctccacagtg cttaccacca cgaccaccac aaccagggcc 10320 accggctctg tggccacccc ctcctccacc ccaggaacag ctcacactac caaagtgccg 10380 actaccacaa ccacgggctt cacagccacc ccctcctcca gcccagggac ggcactcacg 10440 cctccagtgt ggatcagcac aaccaccaca cccacaacca gaggctccac ggtgaccccc 10500 tcctccatcc cggggaccac ccacaccgcc acagtgctga ccaccaccac cacaactgtg 10560 gccactggtt ctatggcaac accctcctct agcacacaga ccagtgggac cacccacaca 10620 cccccagtgc cgaacaccac ggccaccaca cacgggcggt ccctgccccc cagcagtccc 10680 cacacggtgc gcacagcctg gacttcggcc acctcgggca tcttgggcac cacccacatc 10740 acagagcctt ccacggtgac ttcccacacc ccagcagcaa ccaccagtac cacccagcac 10800 tcgactccag ccctgtccag ccctcaccct agcagcagga ccaccgagtc acccccttct 10860 ccagggacga ccaccccggg ccacaccagg ggcacctcca ggaccacagc cacagccaca 10920 cccagcaaga cccgcacctc gaccctgctg cccagcagcc ccacatcggc ccccataacc 10980 acggtggtga ccacgggctg tgagccccag tgtgcctggt cagagtggct ggactacagc 11040 taccccatgc cggggccctc tggcggggac tttgacacct actccaacat ccgtgcggcc 11100 ggaggggcag tctgtgagca gcccctgggc ctcgagtgcc gtgcccaggc ccagcctggt 11160 gtccccctgc gggagttggg ccaggtcgtg gaatgcagcc tggactttgg cctggtctgc 11220 aggaaccgtg agcaggtggg gaagttcaag atgtgcttca actatgaaat ccgtgtgttc 11280 tgctgcaact acggccactg ccccagcacc ccggccacca gctctacggc cacgccctcc 11340 tcaactccgg ggacgacctg gatcctcaca aagctgacca caacagccac tacgactgag 11400 tccactggat ccacggccac cccgtcctcc accccaggga ccacctggat cctcacagag 11460 ccgagcacta cagccaccgt gacggtgccc accggatcca cggccaccgc ctcctccacc 11520 caggcaactg ctggcacccc acatgtgagc accacggcca cgacacccac agtcaccagc 11580 tccaaagcca ctcccttctc cagtccaggg actgcaaccg cccttccagc actgagaagc 11640 acagccacca cacccacagc taccagcttt acagccatcc cctcctcctc cctgggcacc 11700 acctggaccc gcctatcaca gaccaccaca cccacggcca ccatgtccac agccacaccc 11760 tcctccactc cagagactgc ccacacctcc acagtgctta ccaccacggc caccacaacc 11820 agggccaccg gctctgtggc caccccctct tccaccccag gaacagctca cactaccaaa 11880 gtgccgacta ccacaaccac gggcttcaca gtcaccccct cctccagccc agggacggca 11940 cgcacgcctc cagtgtggat cagcacaacc accacaccca caaccagtgg ctccacggtg 12000 accccctcct ccgtcccggg gaccacccac acccccacag tgctgaccac caccaccaca 12060 actgtggcca ctggttctat ggcaacaccc tcctctagca cacagaccag tggtactccc 12120 ccatcactga tcaccacggc cactacgatc acggccaccg gctccaccac caacccctcc 12180 tcaactccag ggacaacacc tatcccccca gtgctgacca ccaccgccac cacacctgca 12240 gccaccagca gcacagtgac tccctcctct gccctaggga ccacccacac acccccagtg 12300

ccgaacacca cggccaccac acacgggcga tccctgtccc ccagcagtcc ccacacggtg 12360 cgcacagcct ggacttcggc cacctcaggc accttgggca ccacccacat cacagagcct 12420 tccacgggga cttcccacac cccagcagca accaccggta ccacccagca ctcgactcca 12480 gccctgtcca gccctcaccc tagcagcagg accaccgagt cacccccttc cccagggacg 12540 accaccccgg gccacaccac ggccacctcc aggaccacgg ccacggccac acccagcaag 12600 acccgcacct cgaccctgct gcccagcagc cccacatcgg cccccataac cacggtggtg 12660 accacgggct gtgagcccca gtgtgcctgg tcagagtggc tggactacag ctaccccatg 12720 ccggggccct ctggcgggga ctttgacacc tactccaaca tccgtgcggc cggaggggcc 12780 gtctgtgagc agcccctggg cctcgagtgc cgtgcccagg cccagcctgg tgtccccctg 12840 ggggagttgg gccaggtcgt ggaatgcagc ctggactttg gcctggtctg caggaaccgt 12900 gagcaggtgg ggaagttcaa gatgtgcttc aactatgaaa tccgtgtgtt ctgctgcaac 12960 tacggccact gccccagcac cccggccacc agctctacgg ccatgccctc ctccactccg 13020 gggacgacct ggatcctcac agagctgacc acaacagcca ctacgactgc atccactgga 13080 tccacggcca ccccgtcctc caccccggga acagctcccc ctcccaaagt gctgaccagc 13140 ccggccacca cacccacagc caccagttcc aaagccactt cctcctccag tccaaggact 13200 gcaaccaccc ttccagtgct gacaagcaca gccaccaaat ccacagctac cagcgttaca 13260 cccatcccct cctccaccct tgggaccacc gggaccctcc cagaacagac caccacaccc 13320 gtggccacca tgtccacaat ccacccctcc tccactccgg agaccaccca cacctccaca 13380 gtgctgacca cgaaggccac cacgacaagg gccaccagtt ccacgtccac cccctcctcc 13440 actccgggga cgacctggat cctcacagag ctgaccacag cagccactac aactgcagcc 13500 actggcccca cggccacccc gtcctccacc ccagggacca cctggatcct cacagagctg 13560 accacaacag ccactacgac tgcgtccact ggatccacgg ccaccccgtc ctccacccca 13620 gggaccacct ggatcctcac agagccgagc actacagcca ccgtgacggt gcccaccgga 13680 tccacggcca ccgcctcctc cacccaggca actgctggca ccccacatgt gagcaccacg 13740 gccacgacac ccacagtcac cagctccaaa gccactccct cctccagtcc agggactgca 13800 actgcccttc cagcactgag aagcacagcc accacaccca cagctaccag ctttacagcc 13860 atcccctcct cctccctggg caccacctgg acccgcctat cacagaccac cacacccacg 13920 gccaccatgt ccacagccac accctcctcc actccagaga ctgtccacac ctccacagtg 13980 cttaccgcca cggccaccac aaccggggcc accggctctg tggccacccc ctcctccacc 14040 ccaggaacag ctcacactac caaagtgccg actaccacaa ccacgggctt cacagccacc 14100 ccctcctcca gcccagggac ggcactcacg cctccagtgt ggatcagcac aaccaccaca 14160 cccacaacca ccacacccac aaccagtggc tccacggtga ccccctcctc catcccgggg 14220 accacccaca ccgccagagt gctgaccacc accaccacaa ctgtggccac tggttctatg 14280 gcaacaccct cctctagcac acagaccagt ggtactcccc catcactgac caccacggcc 14340 actacgatca cggccaccgg ctccaccacc aacccctcct caactccagg gacaacaccc 14400 atcaccccag tgctgaccag cacggccacc acacccgcag ccaccagctc caaagccact 14460 tcctcctcca gtccaaggac tgcaaccacc cttccagtgc tgacaagcac agccacaaaa 14520 tccacagcta ccagctttac acccatcccc tcctccaccc tgtggaccac gtggaccgtc 14580 ccagcacaga ccaccacacc catgtccacc atgtccacaa tccacacctc ctctactcca 14640 gagaccaccc acacctccac agtgctgacc accacagcca ccatgacaag ggccaccaat 14700 tccacggcca caccctcctc cactctgggg acgacccgga tcctcactga gctgaccaca 14760 acagccacta caactgcagc cactggatcc acggccaccc tgtcctccac cccagggacc 14820 acctggatcc tcacagagcc gagcactata gccaccgtga tggtgcccac cggttccacg 14880 gccaccgcct cctccactct gggaacagct cacaccccca aagtggtgac caccatggcc 14940 actatgccca cagccactgc ctccacggtt cccagctcgt ccaccgtggg gaccacccgc 15000 acccctgcag tgctccccag cagcctgcca accttcagcg tgtccactgt gtcctcctca 15060 gtcctcacca ccctgagacc cactggcttc cccagctccc acttctctac tccctgcttc 15120 tgcagggcat ttggacagtt tttctcgccc ggggaagtca tctacaataa gaccgaccga 15180 gccggctgcc atttctacgc agtgtgcaat cagcactgtg acattgaccg cttccagggc 15240 gcctgtccca cctccccacc gccagtgtcc tccgccccgc tgtcctcgcc ctcccctgcc 15300 cctggctgtg acaatgccat ccctctccgg caggtgaatg agacctggac cctggagaac 15360 tgcacggtgg ccaggtgcgt gggtgacaac cgtgtcgtcc tgctggaccc aaagcctgtg 15420 gccaacgtca cctgcgtgaa caagcacctg cccatcaaag tgtcggaccc gagccagccc 15480 tgtgacttcc actatgagtg cgagtgcatc tgcagcatgt ggggcggctc ccactattcc 15540 acctttgacg gcacctctta caccttccgg ggcaactgca cctatgtcct catgagagag 15600 atccatgcac gctttgggaa tctcagcctc tacctggaca accactactg cacggcctct 15660 gccactgccg ctgccgcccg ctgcccccgc gccctcagca tccactacaa gtccatggat 15720 atcgtcctca ctgtcaccat ggtgcatggg aaggaggagg gcctgatcct gtttgaccaa 15780 attccggtga gcagcggttt cagcaagaac ggcgtgcttg tgtctgtgct ggggaccacc 15840 accatgcgtg tggacattcc tgccctgggc gtgagcgtca ccttcaatgg ccaagtcttc 15900 caggcccggc tgccctacag cctcttccac aacaacaccg agggccagtg cggcacctgc 15960 accaacaacc agagggacga ctgtctccag cgggacggaa ccactgccgc cagttgcaag 16020 gacatggcca agacgtggct ggtccccgac agcagaaagg atggctgctg ggccccgact 16080 ggcacacccc ccactgccag ccccgcagcc ccggtgtcta gcacacccac ccccacccca 16140 tgcccaccac agccgctctg tgatctgatg ctgagccagg tctttgctga gtgccacaac 16200 cttgtgcccc cgggcccatt cttcaacgcc tgcatcagcg accactgcag gggccgcctt 16260 gaggtgccct gccagagcct ggaggcttac gcagagctct gccgcgcccg gggagtgtgc 16320 agtgactggc gaggtgcaac cggtggcctg tgcgacctca cctgcccacc caccaaagtg 16380 tacaagccat gcggccccat acagcctgcc acctgcaact ctaggaacca gagcccacag 16440 ctggagggga tggcggaggg ctgcttctgc cctgaggacc agatcctctt caacgcacac 16500 atgggcatct gcgtgcaggc ctgcccctgc gtgggacccg atgggtttcc taaatttccc 16560 ggggagcggt gggtcagcaa ctgccagtcc tgcgtgtgtg acgagggttc agtgtcggtg 16620 cagtgcaagc ccctgccctg tgacgcccag ggtcagcccc cgccgtgcaa ccgtcccggc 16680 ttcgtaaccg tgaccaggcc ccgggccgag aacccctgct gccccgagac ggtgtgcgtg 16740 tgcaacacaa ccacctgccc ccagagcctg cctgtgtgcc cgccagggca ggagtccatc 16800 tgcacccagg aggagggcga ctgctgtccc accttccgct gcagacctca gctgtgttcg 16860 tacaatggca ccttctacgg ggttggtgca accttcccag gcgcccttcc ctgccacatg 16920 tgtacctgcc tctctgggga cacccaggac ccaacggtgc aatgtcagga ggatgcctgc 16980 aacaatacta cctgtcccca gggctttgag tacaagagag tggccgggca gtgctgtggg 17040 gagtgcgtcc agaccgcctg cctcacgccc gatggccagc cagtccagct gaatgaaacc 17100 tgggtcaaca gccatgtgga caactgcacc gtgtacctct gtgaggctga gggtggagtc 17160 catttgctga ccccacagcc tgcatcctgc ccagatgtgt ccagctgcag ggggagcctc 17220 aggaaaaccg gctgctgcta ctcctgtgag gaggactcct gtcaagtccg catcaacacg 17280 accatcctgt ggcaccaggg ctgcgagacc gaggtcaaca tcaccttctg cgagggctcc 17340 tgccccggag cgtccaagta ctcagcagag gcccaggcca tgcagcacca gtgcacctgc 17400 tgccaggaga ggcgggtcca cgaggagacg gtgcccttgc actgtcctaa cggctcagcc 17460 atcctgcaca cctacaccca cgtggatgag tgtggctgca cgcccttctg tgtccctgcg 17520 cccatggctc ccccacacac ccgtggcttc ccggcccagg aggccactgc tgtctgagaa 17580 cgttctgcct ccatccccat gctctgtcca cctggagcca ggatgtgcat tgtctgatca 17640 tgaaaacctt gggcctcctc tgcggagccc cccggcctgt gtgtggcacc ccgcgctccg 17700 tgctcctgct gcccaccccg tgggtgaaac cggccccaga agggtgaggg gccagcagga 17760 cccctttcgg gagggcgcca ctcaggagtc ctaccctggg agagcctgtg gcccaccttg 17820 gccttgcccc tccctgatgt cactggg 17847 <210> SEQ ID NO 26 <211> LENGTH: 3499 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 26 gccaagaagc ttgagagaag aaaaatttca gaaaaattgt ctcaatttga ctagaatatc 60 aatgaaccag gaaaactgaa gcaccttccc taaagaaaac ttgggtatac aattactcca 120 cagacagagc tgagggtttt ttacccaaat cagtcactgg attttgctgc ctgatacgtg 180 aatcttcttg gaatttttct catgtggatc taaggggaat gctttattat ggctgctgtt 240 gtccaacaga acgacctagt atttgaattt gctagtaacg tcatggagga tgaacgacag 300 cttggtgatc cagctatttt tcctgccgta attgtggaac atgttcctgg tgctgatatt 360 ctcaatagtt atgccggtct agcctgtgtg gaagagccca atgacatgat tactgagagt 420 tcactggatg ttgctgaaga agaaatcata gacgatgatg atgatgacat cacccttaca 480 gttgaagctt cttgtcatga cggggatgaa acaattgaaa ctattgaggc tgctgaggca 540 ctcctcaata tggattcccc tggccctatg ctggatgaaa aacgaataaa taataatata 600 tttagttcac ctgaagatga catggttgtt gccccagtca cccatgtgtc cgtcacatta 660 gatgggattc ctgaagtgat ggaaacacag caggtgcaag aaaaatatgc agactcaccg 720 ggagcctcat caccagaaca gcctaagagg aaaaaaggaa gaaaaactaa accaccacga 780 ccagattccc cagccactac gccaaatata tctgtgaaga agaaaaacaa agatggaaag 840 ggaaacacaa tttatctttg ggagttttta ctggcactgc tccaggacaa ggctacttgt 900 cctaaataca tcaagtggac ccagcgagag aaaggcattt ttaaattggt ggattctaaa 960 gcagtgtcca ggttgtgggg gaagcacaaa aacaaacctg atatgaatta tgagaccatg 1020 ggaagagcac tcaggtacta ttaccaaagg ggtattctgg caaaagtgga aggtcagcgc 1080 ttggtgtatc agtttaaaga aatgccaaaa gatcttatat atataaatga tgaggatcca 1140 agttccagca tagagtcttc agatccatca ctatcttcat cagccacttc aaataggaat 1200 caaaccagcc ggtcgagagt atcttcaagt ccaggggtaa aaggaggagc cactacagtt 1260 ctaaaaccag ggaattctaa agctgcaaaa cccaaagatc ctgtggaagt tgcacaacca 1320 tcagaagttt tgaggacagt gcagcccacg cagtctccat atcctaccca gctcttccgg 1380 actgttcatg tagtacagcc agtacaggct gtcccagagg gagaagcagc tagaaccagt 1440 accatgcagg atgaaacatt aaattcttcc gttcagagta ttaggactat acaggctcca 1500 acccaagttc cagtggttgt gtctcctagg aatcagcagt tgcatacagt aacactccaa 1560 acagtgccac tcacaacagt tatagccagc acagatccat cagcaggtac tggatctcag 1620 aagtttattt tacaagccat tccatcatca cagcccatga cagtactgaa agaaaatgtc 1680

atgctgcagt cacaaaaggc gggctctcct ccttcaattg tcttgggccc tgcccaggtt 1740 cagcaggtcc ttactagcaa tgttcagacc atttgcaatg gaaccgtcag tgtggcttcc 1800 tctccatcct tcagtgctac tgcacctgtg gtgacctttt ctcctcgcag ttcacagctg 1860 gttgctcacc cacctggcac tgtaatcact tcagttatca aaactcaaga aacaaaaact 1920 cttacacagg aagtagagaa aaaggaatct gaagatcatt tgaaagagaa cactgagaaa 1980 acggagcagc agccacagcc ttatgtgatg gtagtgtcca gttccaatgg atttacttct 2040 caggtagcta tgaaacaaaa cgaactgctg gaacccaact ctttttagtt aatataccaa 2100 agcttatgaa taattgtttg ttaattgaac attttcaatt atatgcagac tgactgattc 2160 taagataaat tctaaggagg tttctaattt tgtaattgtt aaaaatagag ttaattttga 2220 ctttgttaga tgagggagga aaactcaact gtttctcttt gttatctaaa tgtttcagaa 2280 ttcaatcgtg aaggaacagg cattttacac tatgaagaca ttcttttgag atttttattt 2340 cagttgctat atcataagca tttttaaagt ttcttttcta attttacatt gtattagatt 2400 ttctgattct tttgtaaata cagaacttaa atagaaggca acaggaaatt tatataggaa 2460 ctattttcat tccacttgtg taagttaagt cttgactctt tcaaatgcaa aaaacctatt 2520 ttatgctttg ttaaaattat ggtgtcactt agattgactt tagttgactg cactatataa 2580 tatagaacta tgaatatgta gaataacatg aaaaattgga ggtgctggtg gtatggctga 2640 ccctgtttca gaagcaggat agtataaaag catcagccta agaatggcac tcccactaac 2700 tagctatgta atcttgacct ctttgggctt tagttcctct cataaaagga agagatgtat 2760 tggattagac tagattatca ccactttctc ttctagttct aattttttta attctaatac 2820 ctatattttc aagttatgtc aattaaatca ttatcaggtt atttcctaat gtaagaatag 2880 ctaaaatgtt gcagagaaat aagtgaccca acaaaattta ttcatctgtt atgggtaaga 2940 tctgccataa attcttccta aataatttgt ttactaactc tttaggccac tgtgctttgc 3000 ggtccattag taaacttgtg ttgctaagtg ctaaacagaa tactgctatt ttgagagagt 3060 caagactctt tcttaagggc caagaaagca acttgagcct tgggctaatc tggctgagta 3120 gtcagttata aaagcataat tgctttatat tttggatcat tttttactgg gggcggactt 3180 ggggggggtt gcatacaaag ataacatata tatccaactt tctgaaatga aatgttttta 3240 gattactttt tcaactgtaa ataatgtaca tttaatgtca caagaaaaaa atgtcttctg 3300 caaattttct agtataacag aaatttttgt agatgaaaaa aatcattatg tttagaggtc 3360 taatgctatg ttttcatatt acagagtgaa tttgtattta aacaaaaatt taaattttgg 3420 aatcctctaa acatttttgt atctttaatt ggtttattat taaataaatc atataaaaat 3480 tctcaaaaaa aaaaaaaaa 3499 <210> SEQ ID NO 27 <211> LENGTH: 3302 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27 cggtgctgcc gccgttgccg ggagccgcgg agacaagtca ttacgttttc atttctcaca 60 actgggctga gcacaactga accatggggg aacacagtcc agacaacaac atcatctact 120 ttgaggcaga ggaagatgag ctgacccccg atgataaaat gctcaggttt gtggataaaa 180 acggactggt gccttcctca tctggaactg tttatgatag gaccactgtt cttattgagc 240 aggaccctgg cactttggag gatgaagatg acgacggaca gtgcggagaa cacttgcctt 300 ttctagtagg gggtgaagag ggctttcacc tgatagatca tgaagcaatg tcccagggtt 360 atgtgcagca cattatctca ccagatcaga ttcatttgac aataaaccct ggttccacac 420 ccatgccaag aaatattgaa ggtgcaaccc tcactctgca gtcggaatgt ccggaaacaa 480 aacgtaaaga agtaaagcgg taccaatgta cctttgaggg ctgtccccgc acctacagca 540 cagcaggcaa cctgcgaacc caccagaaga ctcaccgagg agagtacacc tttgtctgta 600 atcaggaggg ctgtggcaaa gccttcctta cctctcacag cctcaggatc cacgtgcgag 660 tgcacacgaa ggagaagcca tttgagtgtg acgtgcaggg ctgtgagaag gcattcaaca 720 cactgtacag gctgaaagca catcagaggc ttcacacagg gaaaacgttt aactgtgaat 780 ctgaaggctg cagcaaatac ttcaccacac tcagtgatct gaggaagcac attcgaactc 840 atacagggga aaagccattt cggtgcgatc acgatggctg tggaaaagca tttgcagcaa 900 gccaccacct taaaactcac gttcgtacac atactggtga aagacccttc ttctgcccca 960 gtaatggctg tgagaaaaca ttcagcactc aatacagtct caaaagtcac atgaaaggtc 1020 atgataacaa aggacactca tacaatgcac ttccacaaca caatggatca gaggatacaa 1080 atcactcact ttgtctaagt gacttgagcc ttctgtccac agattctgaa ttgcgagaaa 1140 attccagtac gacccagggc caggacctca gcacaatttc accagcaatc atctttgaat 1200 caatgttcca gaattcagat gatacggcaa ttcaggaaga tcctcaacag acagcttcct 1260 tgactgaaag ttttaatggt gatgcagagt cagtcagtga tgttccgcca tccacaggaa 1320 attcagcatc tttatctctt ccacttgtac tgcaacctgg cctctccgag ccaccccagc 1380 ctctactacc tgcctcagct ccgtctgctc ctccgcctgc tccctcccta ggacctggct 1440 cccagcaagc tgcatttggc aacccccctg ctctcttaca acctccagaa gtgcctgttc 1500 cccacagcac acagtttgct gctaatcatc aagagtttct tccgcacccc caggcaccgc 1560 agcccattgt accaggactt tctgttgttg ctggggcttc tgcatcagca gcggcagtgg 1620 catcagctgt ggcagcacca gccccaccac aaagtactac tgagcccctg ccagccatgg 1680 tccagactct gcccctgggt gccaactctg tcctaactaa taatcccaca ataaccatca 1740 ccccaactcc caacacagct atcctgcagt ccagcctagt catgggagaa cagaacttac 1800 aatggatatt aaatggtgcc accagttctc cacaaaacca agaacaaatt cagcaagcat 1860 ctaaagttga gaaggtgttt tttaccactg cagtaccagt agccagtagc ccagggagct 1920 ctgtccagca gattggcctc agtgttcctg tgatcatcat caaacaagaa gaggcatgtc 1980 agtgtcagtg tgcatgccgg gactctgcaa aggagcgggc atccagcagg agaaagggct 2040 gctcctcccc accccctcca gagccgagcc cccaggctcc tgatgggccc agcctgcagc 2100 tcccagcgca gactttctct tcagcccctg ttcccgggtc atcatcctct accttgccct 2160 cctcctgtga gcaaagccga caagcagaga ctccttcaga ccctcagaca gaaacattaa 2220 gtgccatgga tgtgtcagag tttctatccc tccagagcct ggacaccccg tccaatctga 2280 ttcccattga agcactactg cagggggagg aggagatggg cctcaccagc agcttctcca 2340 agtgaagggc ccatgtgtgc tcacctctgg gaaaagcggg tgagcaggag gcatgaggta 2400 caatgcctgc catcatgggt cagaaatttg aaggatgaag aaatctactg tttgaaatcc 2460 tcacctttca gacgtatttt ctttattcac atcccaggag catccatttt aaggaactat 2520 tctttggaaa aaaacaaaaa acaaaaaaaa caacaaaaaa agctaagtta taagtgaact 2580 gtttggctgc actgtatgtc acttttgctt gttgtcatgt gaacttggaa actaaggtta 2640 ctcgtgtgca taaaaattct aaatgaaagg gtgtggtttc catcaatctg atgctgccca 2700 tcgcttgcac tggggtcttt gtggatcggg caggagtttt cagtgtgttg ggtgttgctc 2760 cttcctatgt gtcttttgaa tctgaggctg acatttgctt ggaaggccag acccttgctc 2820 catcagagag ggcagtggca aaggccagtg aggcagctgt gagttggaca gggttcaggt 2880 gagatggtgt tgtcatttgt gcttagtgtt ggtggtgctc agggtggata acacgggtcg 2940 ttctgcagcc cgcttcagca caaataggca gcttaaggcc tggctcacag gctgtggggt 3000 tgatctggct ctgcagaggc cctaggcagc ttgttgactg ctgtctgttg atgacgtgtg 3060 tgcaaagcag gctctagcaa catgatcact gtccttgcct tcctggttct ttctctcggt 3120 tggttgccag ggcttgcaga tcgcagtgaa ttttccttgg ggaacatcgc tgttttgtcc 3180 tagagtgaac ttgtggctta tggccagtgc tgtttggtgg tctgccttct ttttaatggt 3240 attttcttcc tcagagcaga agggctgcat tttgcttatc agaagaaggt gcagatttaa 3300 gg 3302 <210> SEQ ID NO 28 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 28 ccttcctctc ctagcctaag gcgtgcaaac agagcgccac tgggaggctg aaacctttag 60 gccgatgctt gcttgcaagg tcaggcaagc tggattctgg tccccacctt tgcagagaga 120 acagcgatgt tgtgcgccca tttctcagat caaggaccgg cccatcttac tacctccaag 180 agtgcttttc tctctaataa gaaaacatct actttgaaac atctactggg cgagaccagg 240 agtgatggct cagcctgtaa ttctggaatt tcgggaggcc gaggcaggaa gattccttga 300 gcacaggagt tccagaccag cctgggcaat gtagcaagac gctgtctcta tttatacaat 360 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 390 <210> SEQ ID NO 29 <211> LENGTH: 2564 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 29 agatacacgg tttttaagaa agaacttcta accccactcc accgcccaac ggtcacgtga 60 cgcgcctgcg tcctcgcctc aaggtttttt ctggtcgcat attggctgtt aactcggcta 120 cggggtgtag cgaggtgcat tccggaagta ggtcctttga cttttgcttc ctctacggag 180 gcaagtaaca acccggcggt cgacgcttag cggaagttcg tcaagtcgca gttgcccccg 240 cacagcggat gtgggtcgcc tcttaggtga cgctgggaag tgcctgcaac cttcgccgct 300 gccttctggt tgaagcacta tggagggaga gaggaagaac aacaacaaac ggtggtattt 360 cactcgagaa cagctggaaa atagcccatc ccgtcgtttt ggcgtggacc cagataaaga 420 actttcttat cgccagcagg cggccaatct gcttcaggac atggggcagc gtcttaacgt 480 ctcacaattg actatcaaca ctgctatagt atacatgcat cgattctaca tgattcagtc 540 cttcacacag ttccctggaa attctgtggc tccagcagcc ttgtttctag cagctaaagt 600 ggaggagcag cccaaaaaat tggaacatgt catcaaggta gcacatactt gtctccatcc 660 tcaggaatcc cttcctgata ctagaagtga ggcttatttg caacaagttc aagatctggt 720 cattttagaa agcataattt tgcagacttt aggctttgaa ctaacaattg atcacccaca 780 tactcatgta gtaaagtgca ctcaacttgt tcgagcaagc aaggacttag cacagacttc 840 ttacttcatg gcaaccaaca gcctgcattt gaccacattt agcctgcagt acacacctcc 900 tgtggtggcc tgtgtctgca ttcacctggc ttgcaagtgg tccaattggg agatcccagt 960 ctcaactgac gggaagcact ggtgggagta tgttgacgcc actgtgacct tggaactttt 1020 agatgaactg acacatgagt ttctacagat tttggagaaa actcccaaca ggctcaaacg 1080 catttggaat tggagggcat gcgaggctgc caagaaaaca aaagcagatg accgaggaac 1140 agatgaaaag acttcagagc agacaatcct caatatgatt tcccagagct cttcagacac 1200

aaccattgca ggtttaatga gcatgtcaac ttctaccaca agtgcagtgc cttccctgcc 1260 agtctccgaa gagtcatcca gcaacttaac cagtgtggag atgttgccgg gcaagcgttg 1320 gctgtcctcc caaccttctt tcaaactaga acctactcag ggtcatcgga ctagtgagaa 1380 tttagcactt acaggagttg atcattcctt accacaggat ggttcaaatg catttatttc 1440 ccagaagcag aatagtaaga gtgtgccatc agctaaagtg tcactgaaag aataccgcgc 1500 gaagcatgca gaagaattgg ctgcccagaa gaggcaactg gagaacatgg aagccaatgt 1560 gaagtcacaa tatgcatatg ctgcccagaa tctcctttct catcatgata gccattcttc 1620 agtcattcta aaaatgccca tagagggttc agaaaacccc gagcggcctt ttctggaaaa 1680 ggctgacaaa acagctctca aaatgagaat cccagtggca ggtggagata aagctgcgtc 1740 ttcaaaacca gaggagataa aaatgcgcat aaaagtccat gctgcagctg ataagcacaa 1800 ttctgtagag gacagtgtta caaagagccg agagcacaaa gaaaagcaca agactcaccc 1860 atctaatcat catcatcatc ataatcacca ctcacacaag cactctcatt cccaacttcc 1920 agttggtact gggaacaaac gtcctggtga tccaaaacat agtagccaga caagcaactt 1980 agcacataaa acctatagct tgtctagttc tttttcctct tccagttcta ctcgtaaaag 2040 gggaccctct gaagagactg gaggggctgt gtttgatcat ccagccaaga ttgccaagag 2100 tactaaatcc tcttccctaa atttctcctt cccttcactt cctacaatgg gtcagatgcc 2160 tgggcatagc tcagacacaa gtggcctttc cttttcacag cccagctgta aaactcgtgt 2220 ccctcattcg aaactggata aagggcccac tggggccaat ggtcacaaca cgacccagac 2280 aatagactat caagacactg tgaatatgct tcactccctg ctcagtgccc agggtgttca 2340 gcccactcag cccactgcat ttgaatttgt tcgtccttat agtgactatc tgaatcctcg 2400 gtctggtgga atctcctcga gatctggcaa tacagacaaa ccccggccac cacctctgcc 2460 atcagaacct cctccaccac ttccacccct tcctaagtaa aaaaagaaaa agaagaggag 2520 aaaaaaactt ctttaaaaaa acacataatt tttctttttt tttt 2564 <210> SEQ ID NO 30 <211> LENGTH: 2948 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 30 gcgtgcgcaa tgggccacag aaccgccatg ccggaaccgc gcgggtcgtc gcagctgcgg 60 gtgaacgcgg cgtttgccgc gcggtacaac cgctaccggg agcgcgagga actgcagcgg 120 cgaatttgat ccccagcagg agcgggactt ttacaaaacg ctctccttgt tgaagaagaa 180 ggacccccgc atttatcaga aagatgccac cttctataac agaacagcat cgtcatcaga 240 cagtgaggag gacccagaag ccttggagaa gcagaagaaa gtgcggccca tgtacctgaa 300 ggactacgag aggaaggtta tcttggagaa ggcaggcaaa tatgttgatg aggagaactc 360 agacggggag acttccaatc acagactcca ggagacatcg tcgcaaagtt atgtggagga 420 acagaaacag ctcaaggaaa gcttccgggc atttgtggag gacagtgagg acgaggacgg 480 cgctggggag ggcggctcca gtttgctgca gaaacgtgcc aaaaccaggc aggagaaggc 540 ccaggaggag gccgactaca tcgagtggct gaagggacag aaagagattc ggaacccaga 600 ttccctgaag gaactgacgc atctcaagga atactggaac gaccctgagt tggatgaagg 660 ggagcggttc ctgcgggatt acatcctcaa caaacgctat gaggaggagg aagaggagga 720 ggaagatgaa gaggaaatgg aggaagagaa gggggtccac ggtcccccag tccagctggc 780 tgtggacgac tcctcagacg aaggggagct gtttctgaag aaacaggagg actttgaaca 840 gaagtacaat ttccgtttcg aggagccgga ctcagcatcg gtcaagacct acccacgcag 900 catcgcgtcc tccgtgcgcc gtaaggatga gcgcagaaag gagaagaggg aagagactcg 960 ggagcgaaag aagagggaga aagcaaagaa gcaggaagag ctcaagcagc tgaagaacct 1020 gaagaggaag gagattctgg ccaagctgga gaagctgcgg aaagtaacag gcaacgagat 1080 gctgggcctc gaggaggggg accttgaaga cgacttcgac cctgcccagc acgaccagct 1140 catgcagaag tgctttgggg acgagtacta cggggccgtg gaggaggaga agccacaatt 1200 tgaggaagaa gaagggcttg aagacgactg gaactgggac acgtgggacg ggcctgagca 1260 ggagggagac tggagccagc aggagctgca ctgtgaggac cccaacttca acatggacgc 1320 cgactacgac cccagccagc cgaggaagaa aaagcgcgag gcccccttga cgggcaagaa 1380 gaagcgcaag tcgcccttcg ccgcggccgt ggggcaggag aagcccgtgt tcgaacccgg 1440 ggacaagacg ttcgaggagt acctggatga gtattaccgg ctggactacg aggacatcat 1500 cgacgacctg ccctgtcgct tcaagtaccg cacagtggtg ccctgtgact ttggcctcag 1560 cactgaggag atcctcgctg ctgacgataa ggagctgaac cggtggtgct ccctaaagaa 1620 gacctgcatg tacaggtcag agcaggagga gctgcgggac aagcgggcgt acagccagaa 1680 ggcccagaac tcatggaaaa agcggcaggt cttcaagtca ctctgccgag aagaggcaga 1740 gacacctgcg gaagccacag ggaagccaca gagagatgaa gccggcccac agaggcagct 1800 gccagccctt gatggcagct tgatggggcc ggagagtccc ccagcacagg aagaggaagc 1860 ccctgtatca ccccacaaga agccagcccc ccagaagcgg aggagggcca agaaggcacg 1920 gctgctgggc cccactgtga tgcttggtgg atgcgagttc agccgccaga gactgcaggc 1980 ctttggcctc aaccccaaac ggctgcactt ccgccagctg ggccggcagc ggaggaaaca 2040 acaggggccc aagaacagct cctgagcacc agggagcagg caggggcctc aggctcctct 2100 cctcaaatca agccctggac aggtctcgca cccacaagta ctatctgctg cagagatcct 2160 ctcatctgtg gccaggcacg cctgtaatcc cagcactttg ggaggccgag gtgaaaggat 2220 cacttgagcc caggaattgg agaccagcgt gggcaactta gcgagactcc atctctacaa 2280 aatgtggtga cacatgcctg tagtcccagc tactcaggag gctggggaag gaagatcact 2340 taaggccatg agtttgaggc tacagagagc tatgattgca ccactgcact ccagcctggg 2400 caacaaagca agaccctgtc tcttgaaaaa aaaaaaaaaa ttaaaaaaca cgtgtagctg 2460 tgggtaagga agtcgtccca ttttatggat gtggaaactg aggctgactt aaacttcccg 2520 tgacttggag ctctcacctc gagacacctc ccagacccca catcccctca gaacgctgcg 2580 cccagccaca cccacgatca agttacacag ctttattggc ccccagcagc cacagttccc 2640 ccaagggggc tttgggacag ggagggcccg ggcgtccagt gcaaactaca gtacgtgagt 2700 caggccctga ggggggtgcc cggggtcctc cttccctacc ctgccaggag ggccccgctg 2760 gtgggagaca ggtgtatggg ctctgtgggc tctgtccctg gctgaatggc cccagactgg 2820 ttgcagctgg gcttgagggg ctgacaacag gaagtaccat catcactgcc agagctcaag 2880 atcccacacc cgacatgaca taaataaaaa aataaatagt gttgtatctt taaaaaaaaa 2940 aaaaaaaa 2948 <210> SEQ ID NO 31 <211> LENGTH: 3022 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 31 gcgtgcgcaa tgggccacag aaccgccatg ccggaaccgc gcgggtcgtc gcagctgcgg 60 gtgaacgcgg cgtttgccgc gcggtacaac cgctaccggg agcgcgagga actgcagcgg 120 ctgaaggatc gctacgggga ccgagacagc agcagcgact ccagctccga gtcggactca 180 agcgacgagc gcgtggaatt tgatccccag caggagcggg acttttacaa aacgctctcc 240 ttgttgaaga agaaggaccc ccgcatttat cagaaagatg ccaccttcta taacagaaca 300 gcatcgtcat cagacagtga ggaggaccca gaagccttgg agaagcagaa gaaagtgcgg 360 cccatgtacc tgaaggacta cgagaggaag gttatcttgg agaaggcagg caaatatgtt 420 gatgaggaga actcagacgg ggagacttcc aatcacagac tccaggagac atcgtcgcaa 480 agttatgtgg aggaacagaa acagctcaag gaaagcttcc gggcatttgt ggaggacagt 540 gaggacgagg acggcgctgg ggagggcggc tccagtttgc tgcagaaacg tgccaaaacc 600 aggcaggaga aggcccagga ggaggccgac tacatcgagt ggctgaaggg acagaaagag 660 attcggaacc cagattccct gaaggaactg acgcatctca aggaatactg gaacgaccct 720 gagttggatg aaggggagcg gttcctgcgg gattacatcc tcaacaaacg ctatgaggag 780 gaggaagagg aggaggaaga tgaagaggaa atggaggaag agaagggggt ccacggtccc 840 ccagtccagc tggctgtgga cgactcctca gacgaagggg agctgtttct gaagaaacag 900 gaggactttg aacagaagta caatttccgt ttcgaggagc cggactcagc atcggtcaag 960 acctacccac gcagcatcgc gtcctccgtg cgccgtaagg atgagcgcag aaaggagaag 1020 agggaagaga ctcgggagcg aaagaagagg gagaaagcaa agaagcagga agagctcaag 1080 cagctgaaga acctgaagag gaaggagatt ctggccaagc tggagaagct gcggaaagta 1140 acaggcaacg agatgctggg cctcgaggag ggggaccttg aagacgactt cgaccctgcc 1200 cagcacgacc agctcatgca gaagtgcttt ggggacgagt actacggggc cgtggaggag 1260 gagaagccac aatttgagga agaagaaggg cttgaagacg actggaactg ggacacgtgg 1320 gacgggcctg agcaggaggg agactggagc cagcaggagc tgcactgtga ggaccccaac 1380 ttcaacatgg acgccgacta cgaccccagc cagccgagga agaaaaagcg cgaggccccc 1440 ttgacgggca agaagaagcg caagtcgccc ttcgccgcgg ccgtggggca ggagaagccc 1500 gtgttcgaac ccggggacaa gacgttcgag gagtacctgg atgagtatta ccggctggac 1560 tacgaggaca tcatcgacga cctgccctgt cgcttcaagt accgcacagt ggtgccctgt 1620 gactttggcc tcagcactga ggagatcctc gctgctgacg ataaggagct gaaccggtgg 1680 tgctccctaa agaagacctg catgtacagg tcagagcagg aggagctgcg ggacaagcgg 1740 gcgtacagcc agaaggccca gaactcatgg aaaaagcggc aggtcttcaa gtcactctgc 1800 cgagaagagg cagagacacc tgcggaagcc acagggaagc cacagagaga tgaagccggc 1860 ccacagaggc agctgccagc ccttgatggc agcttgatgg ggccggagag tcccccagca 1920 caggaagagg aagcccctgt atcaccccac aagaagccag ccccccagaa gcggaggagg 1980 gccaagaagg cacggctgct gggccccact gtgatgcttg gtggatgcga gttcagccgc 2040 cagagactgc aggcctttgg cctcaacccc aaacggctgc acttccgcca gctgggccgg 2100 cagcggagga aacaacaggg gcccaagaac agctcctgag caccagggag caggcagggg 2160 cctcaggctc ctctcctcaa atcaagccct ggacaggtct cgcacccaca agtactatct 2220 gctgcagaga tcctctcatc tgtggccagg cacgcctgta atcccagcac tttgggaggc 2280 cgaggtgaaa ggatcacttg agcccaggaa ttggagacca gcgtgggcaa cttagcgaga 2340 ctccatctct acaaaatgtg gtgacacatg cctgtagtcc cagctactca ggaggctggg 2400 gaaggaagat cacttaaggc catgagtttg aggctacaga gagctatgat tgcaccactg 2460 cactccagcc tgggcaacaa agcaagaccc tgtctcttga aaaaaaaaaa aaaattaaaa 2520 aacacgtgta gctgtgggta aggaagtcgt cccattttat ggatgtggaa actgaggctg 2580 acttaaactt cccgtgactt ggagctctca cctcgagaca cctcccagac cccacatccc 2640

ctcagaacgc tgcgcccagc cacacccacg atcaagttac acagctttat tggcccccag 2700 cagccacagt tcccccaagg gggctttggg acagggaggg cccgggcgtc cagtgcaaac 2760 tacagtacgt gagtcaggcc ctgagggggg tgcccggggt cctccttccc taccctgcca 2820 ggagggcccc gctggtggga gacaggtgta tgggctctgt gggctctgtc cctggctgaa 2880 tggccccaga ctggttgcag ctgggcttga ggggctgaca acaggaagta ccatcatcac 2940 tgccagagct caagatccca cacccgacat gacataaata aaaaaataaa tagtgttgta 3000 tctttaaaaa aaaaaaaaaa aa 3022 <210> SEQ ID NO 32 <211> LENGTH: 2044 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 ctggacgagt ccgagcgcgt cacctcctca cgctgcggct gtcgcccgtg tcccgccggc 60 ccgttccgtg tcgccccgca gtgctgcggc cgccgcggca ccatggctgt gtttgtcgtg 120 ctcctggcgt tggtggcggg tgttttgggg aacgagttta gtatattaaa atcaccaggg 180 tctgttgttt tccgaaatgg aaattggcct ataccaggag agcggatccc agacgtggct 240 gcattgtcca tgggcttctc tgtgaaagaa gacctttctt ggccaggact cgcagtgggt 300 aacctgtttc atcgtcctcg ggctaccgtc atggtgatgg tgaagggagt gaacaaactg 360 gctctacccc caggcagtgt catttcgtac cctttggaga atgcagttcc ttttagtctt 420 gacagtgttg caaattccat tcactcctta ttttctgagg aaactcctgt tgttttgcag 480 ttggctccca gtgaggaaag agtgtatatg gtagggaagg caaactcagt gtttgaagac 540 ctttcagtca ccttgcgcca gctccgtaat cgcctgtttc aagaaaactc tgttctcagt 600 tcactccccc tcaattctct gagtaggaac aatgaagttg acctgctctt tctttctgaa 660 ctgcaagtgc tacatgatat ttcaagcttg ctgtctcgtc ataagcatct agccaaggat 720 cattctcctg atttatattc actggagctg gcaggtttgg atgaaattgg gaagcgttat 780 ggggaagact ctgaacaatt cagagatgct tctaagatcc ttgttgacgc tctgcaaaag 840 tttgcagatg acatgtacag tctttatggt gggaatgcag tggtagagtt agtcactgtc 900 aagtcatttg acacctccct cattaggaag acaaggacta tccttgaggc aaaacaagcg 960 aagaacccag caagtcccta taaccttgca tataagtata attttgaata ttccgtggtt 1020 ttcaacatgg tactttggat aatgatcgcc ttggccttgg ctgtgattat cacctcttac 1080 aatatttgga acatggatcc tggatatgat agcatcattt ataggatgac aaaccagaag 1140 attcgaatgg attgaatgtt acctgtgcca gaattagaaa agggggttgg aaattggctg 1200 ttttgttaaa atatatcttt tagtgtgctt taaagtagat agtatacttt acatttataa 1260 aaaaaaatca aattttgttc tttattttgt gtgtgcctgt gatgtttttc tagagtgaat 1320 tatagtattg acgtgaatcc cactgtggta tagattccat aatatgcttg aatattatga 1380 tatagccatt taataacatt gatttcattc tgtttaatga atttggaaat atgcactgaa 1440 agaaatgtaa aacatttaga atagctcgtg ttatggaaaa aagtgcactg aatttattag 1500 acaaacttac gaatgcttaa cttctttaca cagcataggt gaaaatcata tttgggctat 1560 tgtatactat gaacaatttg taaatgtctt aatttgatgt aaataactct gaaacaagag 1620 aaaaggtttt taacttagag tagccctaaa atatggatgt gcttatataa tcgcttagtt 1680 ttggaactgt atctgagtaa cagaggacag ctgtttttta accctcttct gcaagtttgt 1740 tgacctacat gggctaatat ggatactaaa aatactacat tgatctaaga agaaactagc 1800 cttgtggagt atatagatgc ttttcattat acacacaaaa atccctgagg gacattttga 1860 ggcatgaata taaaacattt ttatttcagt aacttttccc cctgtgtaag ttactatggt 1920 ttgtggtaca acttcattct atagaatatt aagtggaagt gggtgaattc tactttttat 1980 gttggagtgg accaatgtct atcaagagtg acaaataaag ttaatgatga ttccaaaaaa 2040 aaaa 2044 <210> SEQ ID NO 33 <211> LENGTH: 4000 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 cggccgcttt tttctcaaga tggcagattc ccactgaggc tgagggggcc gagctcgcgc 60 gccgcgttcc cttctccgtt gccatgaacc gcggacaccc cggccccgat ggcccccgtg 120 tacgaaggta tggcctcaca tgtgcaagtt ttctcccctc acacccttca atcaagtgcc 180 ttctgtagtg tgaagaaact aaaagtagag ccaagttcca actgggacat gactgggtac 240 ggctcccaca gcaaagtgta cagccagagc aagaacatac caccttctca gccagcctcc 300 acaaccgtca gcacctcctt gccggtccca aacccaagcc taccttacga gcagaccatc 360 gtcttcccag gaagcaccgg gcacatcgtg gtcacctcag caagcagcac ttctgtcacc 420 gggcaagtcc tcggcggacc acacaaccta atgcgtcgaa gcactgtgag cctccttgat 480 acctaccaaa aatgtggact caagcgtaag agcgaggaga tcgagaacac aagcagcgtg 540 cagatcatcg aggagcatcc acccatgatt cagaataatg caagcggggc cactgtcgcc 600 actgccacca cgtctactgc cacctccaaa aacagcggct ccaacagcga gggcgactat 660 cagctggtgc agcatgaggt gctgtgctcc atgaccaaca cctacgaggt cttagagttc 720 ttgggccgag ggacgtttgg acaagtggtc aagtgctgga aacggggcac caatgagatc 780 gtagccatca agatcctgaa gaaccgccca tcctatgccc gacaaggtca gattgaagtg 840 agcatcctgg cccggttgag cacggagagt gccgatgact ataacttcgt ccgggcctac 900 gaatgcttcc agcacaagaa ccacacgtgc ttggtcttcg agatgttgga gcagaacctc 960 tatgactttc tgaagcaaaa caagtttagc cccttgcccc tcaaatacat tcgcccagtt 1020 ctccagcagg tagccacagc cctgatgaaa ctcaaaagcc taggtcttat ccacgctgac 1080 ctcaaaccag aaaacatcat gctggtggat ccatctagac aaccatacag agtcaaggtc 1140 atcgactttg gttcagccag ccacgtctcc aaggctgtgt gctccaccta cttgcagtcc 1200 agatattaca gggcccctga gatcatcctt ggtttaccat tttgtgaggc aattgacatg 1260 tggtccctgg gctgtgttat tgcagaattg ttcctgggtt ggccgttata tccaggagct 1320 tcggagtatg atcagattcg gtatatttca caaacacagg gtttgcctgc tgaatattta 1380 ttaagcgccg ggacaaagac aactaggttt ttcaaccgtg acacggactc accatatcct 1440 ttgtggagac tgaagacacc agatgaccat gaagcagaga cagggattaa gtcaaaagaa 1500 gcaagaaagt acattttcaa ctgtttagat gatatggccc aggtgaacat gacgacagat 1560 ttggaaggga gcgacatgtt ggtagaaaag gctgaccggc gggagttcat tgacctgttg 1620 aagaagatgc tgaccattga tgctgacaag agaatcactc caatcgaaac cctgaaccat 1680 ccctttgtca ccatgacaca cttactcgat tttccccaca gcacacacgt caaatcatgt 1740 ttccagaaca tggagatctg caagcgtcgg gtgaatatgt atgacacggt gaaccagagc 1800 aaaacccctt tcatcacgca cgtggccccc agcacgtcca ccaacctgac catgaccttt 1860 aacaaccagc tgaccactgt ccacaaccag gctccctcct ctaccagtgc cactatttcc 1920 ttagccaatc ccgaagtctc catactaaac tacccatcta cactctacca gccctcagcg 1980 gcatccatgg ctgcagtggc ccagcggagc atgcccctgc agacaggaac agcccagatt 2040 tgtgcccggc ctgacccgtt ccagcaagct ctcatcgtgt gtccccccgg cttccaaggc 2100 ttgcaggcct ctccctctaa gcacgctggc tactcggtgc gaatggaaaa tgcagttccc 2160 atcgtcactc aagccccagg agctcagcct cttcagatcc aaccaggtct gcttgcccag 2220 caggcttggc caagtgggac ccagcagatc ctgcttcccc cagcatggca gcaactgact 2280 ggagtggcca cccacacatc agtgcagcat gccaccgtga ttcccgagac catggcaggc 2340 acccagcagc tggcggactg gagaaatacg catgctcacg gaagccatta taatcccatc 2400 atgcagcagc ctgcactatt gaccggtcat gtgacccttc cagcagcaca gcccttaaat 2460 gtgggtgtgg cccacgtgat gcggcagcag ccaaccagca ccacctcctc ccggaagagt 2520 aagcagcacc agtcatctgt gagaaatgtc tccacctgtg aggtgtcctc ctctcaggcc 2580 atcagctccc cacagcgatc caagcgtgtc aaggagaaca cacctccccg ctgtgccatg 2640 gtgcacagta gcccggcctg cagcacctcg gtcacctgtg ggtggggcga cgtggcctcc 2700 agcaccaccc gggaacggca gcggcagaca attgtcattc ccgacactcc cagccccacg 2760 gtcagcgtca tcaccatcag cagtgacacg gacgaggagg aggaacagaa acacgccccc 2820 accagcactg tctccaagca aagaaaaaac gtcatcagct gtgtcacagt ccacgactcc 2880 ccctactccg actcctccag caacaccagc ccctactccg tgcagcagcg tgctgggcac 2940 aacaatgcca atgcctttga caccaagggg agcctggaga atcactgcac ggggaacccc 3000 cgaaccatca tcgtgccacc cctgaaaacc caggccagcg aagtattggt ggagtgtgat 3060 agcctggtgc cagtcaacac cagtcaccac tcgtcctcct acaagtccaa gtcctccagc 3120 aacgtgacct ccaccagcgg tcactcttca gggagctcat ctggagccat cacctaccgg 3180 cagcagcggc cgggccccca cttccagcag cagcagccac tcaatctcag ccaggctcag 3240 cagcacatca ccacggaccg cactgggagc caccgaaggc agcaggccta catcactccc 3300 accatggccc aggctccgta ctccttcccg cacaacagcc ccagccacgg cactgtgcac 3360 ccgcatctgg ctgcagccgc tgccgctgcc cacctcccca cccagcccca cctctacacc 3420 tacactgcgc cggcggccct gggctccacc ggcaccgtgg cccacctggt ggcctcgcaa 3480 ggctctgcgc gccacaccgt gcagcacact gcctacccag ccagcatcgt ccaccaggtc 3540 cccgtgagca tgggcccccg ggtcctgccc tcgcccacca tccacccgag tcagtatcca 3600 gcccaatttg cccaccagac ctacatcagc gcctcgccag cctccaccgt ctacactgga 3660 tacccactga gccccgccaa ggtcaaccag tacccttaca tataaacact ggaggggagg 3720 gagggaggga gggagggaga gaatggcccg agggaggagg gagagaagga gggaggcgct 3780 cctgggaccg tgggcgctgg ccttttatac tgaagatgcc gcacacaaac aatgcaaacg 3840 gggcaggggc gggggggggg ggggcagagg gcagggggac gggtcgggac accagtgaaa 3900 cttgaaccgg gaagtgggag gacgtagagc agagaagaga acatttttaa aaggaaggga 3960 ttaaagaggg tgggaaatct atggttttta ttttaaaaaa 4000 <210> SEQ ID NO 34 <211> LENGTH: 5652 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 34 cttgctgtta atgaacttgg ttaaacatgg tcaagtgtat gtatgtatat attatcagta 60 ctggccttct ctatctaaga ggaatagcaa gaaatttaga gacattattt ggacattgat 120 ttctactaac tccactgaat tagattcagc cttcactttt tgggaaatgc acggacactg 180 ggaaagatga aatgaagaag ttttccagca tgatgttctt gtctttggag cttagcctta 240 cttaggtctt agaacaaaaa caagtcggta gttattagtt actgtatctc attttccaaa 300

acacacgttt ctttgttaca gtcatttaca catatttttg catgccacat ttttgctttt 360 gagcttttgc tgaatcacta aatgaccacc tttcatgttc ctaatgtatt aaaattatca 420 gaggattctt tgaggattaa atgtgtcagt aagggtatta ttttgaacaa tgcgtaaaag 480 gtgaaggcca gctgaagagg cctttttgtt gtgaacagaa taatatactg gaatctgagg 540 actgcactgt tatgaatgga ttatttggct atggaaagaa gttattttta ggcacagcat 600 ccctataagc cctgaagcta tgtgttttac aaactagaaa ttatgcacta aataaaaatt 660 accagatgtc agtctctgta tgtgccaaat ggcaaatgtg taatggttca gagcctggaa 720 gaaatgatgc ttatttcttt gccattcaaa ctcaaaaggg atagctgagg tagagtgctg 780 ttgaaaaaat tgcagtgttt ccagctaccc aaagatgtta cgaattgtta tctgaaaggc 840 tttcattctt tcccctcatg gctcgttgtg tgtttgtggc attacaaatg taacccacat 900 atttattcta atttattaca ttctttcctg aggctcctct tgttctttta aagggtcagc 960 agataactta ttttaagaat caacctggac acagtattct aacaaaggtc caatacagag 1020 ctaaataaat aataggagtc atagccagac acagtgactc acgcctgtaa tcccaacatt 1080 ttgggaggcc aaggcgggtg gattacctgg tggtgcatgc ctgtagtctc agctactcag 1140 gaggctgagg caggagaatc acttgaaccc gggacgcaga ggttacagtg aaccgagatt 1200 gcgccactgc actccagcct gggcaacaga gcgagacctc tatctcaaaa ataaataaat 1260 aaatacattt aaaatatata tatatatata tatatatata tatatatata tatatatata 1320 tatatatata tttatatata tttcgtgact tatatcttgc acataccagc atacctcatt 1380 aattttaatg taaccatcca ttggcttctc ttctctcctt agaaattcga gctcaactgg 1440 tagaacaaca aaaatgcctg gagcagcaaa cggagatgcg agttcagctt ctccaggatc 1500 tgcaagattt cttccgaaaa aaagctgaaa ttgagacgga atattcccgg aatctagaga 1560 agttagcaga aaggttcatg gcaaaaacaa gaagcactaa ggatcatcaa caatacaaga 1620 aagaccagaa cctgttgtct ccagtgaact gctggtattt gctcctgaac caagtaagga 1680 gagaaagcaa agaccatgca accttgagtg acatctatct gaacaatgtg attatgcggt 1740 tcatgcagat aagtgaggat tctaccagga tgtttaaaaa gagcaaagag attgcattcc 1800 aacttcatga ggatttaatg aaggttctta atgagcttta tacggtgatg aaaacatacc 1860 atatgtatca tgcagagagc atcagtgcag agagcaagct gaaagaggcc gaaaaacaag 1920 aggaaaagca aattgggaga tctggtgatc cagtcttcca tattcgacta gaggagagac 1980 atcaacggcg aagctctgta aagaaaattg aaaaaatgaa agaaaaaaga caagcaaaat 2040 attcagaaaa taagctaaaa tcaattaagg cacggaacga atatctccta acacttgaag 2100 ccaccaatgc ctcagttttc aagtactata ttcatgatct ttctgattta attgattgct 2160 gtgatcttgg ctaccatgca agtctgaaca gagccctaag aacatatctg tctgcggagt 2220 acaaccttga aacctccaga catgagggct tagacattat tgagaatgca gttgataatt 2280 tagagcccag gagcgataag cagagattca tggagatgta ccctgctgcg ttctgtccac 2340 caatgaagtt tgagtttcag tctcacatgg gtgatgaggt gtgccaggtc agtgcccagc 2400 agccagtcca ggcagagctc atgctcaggt accaacagtt gcagtcccgc cttgccacgc 2460 tcaaaatcga gaatgaagag gttaagaaaa cgactgaagc caccttgcag acgatacaag 2520 atatggtcac catcgaggac tatgatgttt ctgaatgctt ccagcacagt cgttccacag 2580 aatcagtgaa gtccactgtc tctgaaacct acctgagtaa acccagcatc gccaagagaa 2640 gagccaacca gcaggaaact gaacagttct acttcatgaa actcagagaa tatttggaag 2700 gcagtaatct catcacaaaa cttcaagcca aacatgactt gctgcagagg accctgggag 2760 aaggtcatag agctgaatat atgactacaa gccgaggacg aagaaactcg cacacaagac 2820 atcaggactc aggacaggtt attcccctca ttgtggaaag ctgtattcgg ttcatcaatc 2880 tctatggtct tcagcatcag gggattttca gagtgtctgg ttcccaggtg gaagtcaatg 2940 atattaaaaa ttcatttgag agaggtgaaa atcctttggc tgatgaccag agtaaccatg 3000 atattaactc agttgctggc gttctgaagc tctatttccg tgggctggaa aaccccctct 3060 ttcctaagga aagatttaac gatctgattt cttgtatcag aatagataat ctctatgaga 3120 gggcgcttca catccgcaaa ctcctcctga ctttgcccag gtcggtcctt atagtgatga 3180 ggtacctctt tgccttcctc aatcatctat cacagtacag cgatgagaat atgatggacc 3240 cttataacct ggccatttgc tttggcccaa cattgatgcc tgtcccagaa atacaggatc 3300 aagtgtcttg ccaggcacat gtgaatgaaa ttatcaaaac catcatcatc caccatgaga 3360 ctattttccc agatgctaaa gagctggatg gccctgttta tgagaaatgt atggctggag 3420 atgactattg cgacagccca tacagtgagc acggtacatt ggaggaagtg gaccaagatg 3480 ctggtacaga gccccacaca agtgaagatg aatgtgagcc aatagaagca atagccaagt 3540 ttgactatgt tgggcggtct gccagagaac tatccttcaa gaagggtgcc tccctgctgc 3600 tgtatcaccg tgcatctgag gactggtggg aaggcaggca caacgggatt gacgggctgg 3660 tgcctcacca gtatatagtg gtgcaggata tggatgatac gttttcagac actctgagcc 3720 aaaaagccga cagtgaggcc agcagtgggc cagtcacgga agacaagtcc tcatccaagg 3780 acatgaactc cccgacagac cgtcatcctg acggctattt agccaggcaa cgaaaaagag 3840 gagagccacc ccctccagta aggcgtcctg gcaggaccag tgatggccat tgcccgctcc 3900 accctccaca tgccctttct aactcctcag ttgacctagg gtccccaagc cttgccagtc 3960 acccccgggg cctgctgcag aaccgtggcc tcaacaatga cagtcctgag cggaggcgca 4020 ggcctggcca tggcagcctg accaacatca gccggcacga ctccctcaag aagatcgaca 4080 gccctcccat tagaaggtcc acgtcatcag ggcaatacac gggcttcaat gaccacaagc 4140 cactggaccc agagacaatt gctcaggata ttgaagaaac gatgaacaca gctttgaatg 4200 aactccgaga actggagaga cagagcacag caaagcatgc ccctgatgtg gtgctggata 4260 ccctggagca agtgaaaaac tctcccaccc ctgccacttc cacggaatct ctcagccctt 4320 tgcacaacgt tgccctcagg agctccgagc ctcagattcg acgtagcacg agctcctcca 4380 gtgacacaat gagtactttc aagcctatgg tggcacccag aatgggcgtg cagctgaagc 4440 ctccagccct taggccaaaa cctgctgttc ttccaaaaac aaatcctacc ataggacctg 4500 ccccacctcc ccagggtcca acagacaagt catgcacaat gtaaaaacca gccaagcaag 4560 gccataaagg gaggtgactt aaaaaagaaa atggattagt gacaaaagtc actgatccat 4620 aactttcctt agttttgtgc ttataactgg agatcttttg gcttttctat gttgtcgaat 4680 gtaatgtctg agactagcta aattaacacg ggcatttgta ttttgtaatt tttttaaata 4740 actggacata tgtcatttta aggacaatag aaacacttag acttacttga aaatccaatg 4800 ctgcaccact tgtaatgaag gcaacaccgc tctccacatt gtacagagct tcaggtttaa 4860 tgtagcccag ctgagtcaga aaggttgtga cctgaaggca gaagaacccg aatgccacac 4920 ctcattggag tatagccagt gttggtctgt ggcacttggg ctgaaaggtg ataatggcat 4980 tgcgtggtag ctgacaatga gcaccttcgg ttccatgtgg agcggggttt agctcatgca 5040 aaagacttgc aattgtctcc atgggacgat cccagtggga ctgtcagccc acagctcgag 5100 tgggttggat gcttgcctct ttcctaacag ttatttcccc gggtccagct taaagactcg 5160 atggaaggag gtagaacctc tgctgttact gcttgaactt aacctgggaa aggagaggaa 5220 gacaccatct ccaaagctat taatgtcact ccttttgcga gcatgattag gccccggaga 5280 tttccaagtc cccccatcta cacttacaaa cgattagaag ggtttaattt taaagacttt 5340 ctggttacac tactccacga actcctccaa agatccgtta ttcaataact gcctagaaaa 5400 tgtttccatc tcctctaaat ccctgtgttc tcctctgtgg aaatgaaggc agcaagaagc 5460 acctgaggcc ttggttcatg cagtgttctc ttttgactaa atcacctagg ttcctttaaa 5520 catgctacaa agcccaggca tggtggtgca cacctgtact cccagctact cgggtggttt 5580 acacaggagg atggctttgg gcctagtagt tcgagtccag cctgggcagc atagtgtgag 5640 accctgtctc tt 5652 <210> SEQ ID NO 35 <211> LENGTH: 2920 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 35 tgtcaaccag cactttttaa gatgaactgt aaccaactag cttctcacat gcttctcata 60 tggtaagagt taattttagc tcatgaaact tttggttctg tgaaacacct gctgaacaga 120 ctcctgggaa gggggtctgt gggagtcgac atttatacaa ccttccaggt gattctgagc 180 ttatcagagc tggagaggca cttgctaccc aggggcttgg tgtggaacgt gagatgccaa 240 agccaaattc aggcctctca gctcaaggca ccctgaagca cagctagtca ctccagcaca 300 tgttgaagct gtgcatgttt acttcatgtt gaactgttca tgttttattt ttggaacact 360 ggggattggc aaaaaaaaaa aaaacccatg tgaataaagc cttctagggc accactgtgc 420 cgattgtgaa ccacacgtgg acaaaacaag ccgcgcttga tagcaactac ctacatgacc 480 agcactcccc tggatgctga tgctgccatg cgagacggga cgttggcgca gcagcatgcc 540 agccacccat tgcttctcct gcttgccaac tcaaccgtgc tgctccctca gacaccatca 600 cttgcgcctc ccaagcaatg gaagccctgg cgatgctctc atgagcccct cactccagca 660 gagcccctga ccaagccagg ggagcaggac ttttccagcc aaggacacaa cggactggtg 720 gctgtgagta cctccccact tgatcccact tcactggccc tgggcgtgtg gctctcagca 780 gcctgggaag gagtgtgaag aagcaggtgg gataagggcc ttgagagaga aggaaaaggc 840 agcctagtcg atgctctctg ctctccagtg ctgactgggg gctgggtcga atgctcatct 900 gcagccagct gtggacatca caggctcctt tcctcccctt cccctaatgg ggaaaggtgg 960 tttccccatg gcctgtgagg gagtcaggga gcttccagaa acaagctgac aaggtgggga 1020 agcatgtaac caacacagca tgagagcagg cagcgtacct gcagagactg ggggtgaaca 1080 ccgccgtctt cgagaggcgc catgtgatcg ggggtgcagc tgtcactgag gagatcatcc 1140 cagggtttaa gttctcccgc gcgtcctacc tgctcagcct gctgaggccg cagatttaca 1200 ctgatctgga gctgaagaaa catgggctga ggcttcatct tcgaaacccc tactccttca 1260 cccccatgct ggaagagggt gcaggcagca aggtgcccag gtgccttctg ctgggcacag 1320 acatggcaga aaaccagaag cagatcgccc agttctccca gaaggatgcc caggtctttc 1380 ccaaatatga ggagttcatg catcgcttgg cattagccat tgaccctctg ctggatgcgg 1440 cccccgtgga catggcggcc ttccagcatg gctccttgct gcaaaggatg aggtcgctct 1500 ccaccctcaa gcccctgctg aaggcaggcc gcatcctggg agcccagctt ccccgatatt 1560 atgaggtcct cacagctccc attaccaagg tgctggatca gtggttcgag tctgagcctt 1620 taaaagccac tctagccaca gatgcagtga ttggagccat gacaagtccc cacactccgg 1680 ggagtgggta tgtgctgctg caccatgtga tggggggcct ggagggaatg cagggggcct 1740 ggggctacgt ccaggggggc atgggtgccc tctctgatgc gatcgcaagc tcagccacca 1800 cacatggagc aagcatcttc actgaaaaga cagtggcgaa ggtgcaggtg aacagtgaag 1860

gctgtgttca aggagttgtg ctggaagatg gcacagaggt gagaagcaaa atggtgctgt 1920 ccaacacatc accgcagatc accttcctga agctgacgcc acaggagtgg cttcctgagg 1980 agttcctgga gagaatctct cagctggaca cccggtcgcc tgtcaccaag atcaatggta 2040 agaggcacac cacattgcag cactgtctcc tttgacccat ctgagtgaga aacctccagg 2100 ctgggggcag ctgaactcag tcatcatctc cattcccgga cctccagcct gtgtccccct 2160 gcagcctggt cagaagtggc cgtagacagg ctgcccagct tcctggcggc ccccaatgct 2220 cccaggggcc agccgctgcc ccatcaccaa tgctccatcc acctgaactg tgaagacacc 2280 ctcctccttc atcaggcctt tgaagatgcc atggatggcc tgccttccca cagtgtttga 2340 ttgcatcgag gtctatgccc ctggcttcaa ggactctgtg gttggcagag acatcctcac 2400 accaccagat ttggagagaa tcttcgggct tcctggaggg aacatattcc actgcgccat 2460 gtccctggac cagctctact tcgcccgccc cgtgcccctg cattctggct accgctgccc 2520 tctccagggc ctgtatctct gtggaagtgg ggctcatcct ggaggaggtg tgatgggagc 2580 tgctgggcga aatgcagcac atgtggcctt tagggacctc aagagcatgt gaccctgaac 2640 cagctctgac ccaggaagaa gactccaccc ctgaattcca agtgctccat tggatcagct 2700 tcccaggaag ttcagcttcg ggttagtaca taaggccacc acaatgctca agaaattatt 2760 ttagaaaaaa cgtacgagtt acatttagtg caagttgacc ttatgcccat gcctccatac 2820 atggactggt tctgttttat taaaactaat atttcataca aaaaaaaaaa aaaaaaaaaa 2880 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2920 <210> SEQ ID NO 36 <211> LENGTH: 2129 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 cgtaatggcg gacacaggca gggcgagcgc ggctgggggc gtagcgcgct gagggggtcc 60 ggccgtttgg cagcccgcga ggcggtccgc gggagcacac tctgtgcgga gactgggcgg 120 ccggccgacc cttcctgtcg ctgacggcga ctgcgggagg ccaggttgtt tttcaccatt 180 cagaacattg cctgaagcag gtccaccatg ccgttagtaa cgaggaacat cgagccaagg 240 cacctgtgcc gtcagacgtt gcctagcgtt agaagcgagc tggaatgcgt gaccaacatc 300 accctggcaa atgtcatccg acagctgggc agcctgagta aatatgcaga ggacattttt 360 ggagagctct ttactcaggc aaataccttt gcctctcggg taagctccct tgctgagagg 420 gtcgaccgac tacaggttaa agtcactcag ctggatccca aggaagaaga agtgtcactg 480 caaggaatca acacccgaaa agccttcaga agttccacca ttcaagacca gaagcttttt 540 gacagaaact ctctcccagt gcctgtctta gaaacataca atacctgtga tactcctccc 600 cctctcaaca atcttacccc ttacagggac gatggaaaag aggcactcaa attctacaca 660 gacccttcat acttctttga tctttggaag gagaagatgc tgcaggacac caaggatatc 720 atgaaagaga agagaaagca taggaaagaa aagaaagata atccaaatcg agggaatgta 780 aacccacgta aaatcaagac acgtaaggaa gagtgggaga aaatgaagat ggggcaagaa 840 tttgtggagt ccaaagaaaa gctggggact tctgggtatc cacccacttt ggtgtaccag 900 aatggcagca ttggctgtgt tgaaaacgtg gatgcaagta gctatccgcc accaccacag 960 tcagactctg cttcttcacc ttctccttcc ttctccgagg acaacttgcc tcctccacca 1020 gcagaattca gttacccagt ggacaaccaa agaggatctg gtttggctgg acccaaaaga 1080 tccagtgtgg tcagcccaag ccatccacca ccagctcctc ctctaggctc tccaccaggc 1140 cctaaacccg ggtttgctcc accacctgcc cctccgccac ctccgcctcc aatgataggc 1200 atcccacctc caccaccgcc tgtaggattt gggtctccag ggacgcctcc accaccctca 1260 cccccatctt tcccacctca ccctgatttt gctgcccctc cacctcctcc tccaccacca 1320 gcagctgact acccaactct gccaccacct cccttgtccc agccaacagg aggagcacct 1380 cctcctcccc ctcctcctcc tcctccgggg ccccctcctc cccctttcac tggtgcagat 1440 ggccaacctg ctataccacc accgctttct gataccacca agcccaagtc ctccttgcct 1500 gccgtgagcg atgcccgtag cgacctgctt tcagccatcc gtcaaggttt tcagctgcgc 1560 agggttgagg agcagcggga acaagagaag cgggatgttg tgggcaatga cgtggccacc 1620 atcttgtctc gtcgcattgc tgttgagtac agtgactcag aagatgactc ctctgaattt 1680 gatgaggacg actggtccga ttaactcttt ctgcctgctg cccaccttct ttttctttcc 1740 ttcctacctg ccttctttga tgccaacccc aacagacccg tagggggaga aaagggagga 1800 aaaaagtaat tttaaggggc caaagctttc cctgaagcaa ccaaagatat atccaagtgc 1860 ttcctccaag tcaacatgta tttcctctcc ccattttcag gccctgtggg gctcctgagg 1920 ttcagtagct gggatgttcc ctctttcctt caagtgcctg ttgcatattg aaaggaagga 1980 gaaatcccaa agcagattcc tttgatcggg tttctgttgg agatggggct tcccttagga 2040 gccatattca actacagcct tctaaaacct gtgccctcag ccactttaaa aaaaaaaaaa 2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2129 <210> SEQ ID NO 37 <211> LENGTH: 4878 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 37 gtccgccatt tgcaaggggc ccggagcggg atcgcggcac ctgccgagcg ggtcgccgcc 60 tctgccgcgg tccttggacc ccgccgccgc cctggcctgg gagcttgccc cgccgcagcg 120 gccggcagcg cggcgctccg cgggcggcag gcacgggccc cgggccccct cacggcgccc 180 agccgcgggc ctcccgaggc aaaagcccgt gggccgccgc gatggccctc aagatggtga 240 agggcagcat cgaccgcatg ttcgacaaga atctgcagga cttggtccgc ggcatccgta 300 accacaagga ggacgaggca aaatacatat ctcagtgcat tgatgagatc aagcaggagc 360 tgaagcagga caacatagcg gtgaaggcga acgcggtctg caagctgacg tatttacaga 420 tgttgggata cgacatcagc tgggccgcct tcaacatcat agaagtgatg agtgcctcca 480 agttcacctt caagcgaatt ggctacctcg ctgcttccca gagctttcac gaaggcaccg 540 acgtcatcat gctgaccacc aatcagatcc gtaaggactt gagcagcccc agccagtacg 600 acacaggtgt tgcactgacg ggtctgtcct gcttcgtcac cccagacctt gccagagacc 660 tggcaaatga catcatgaca ctgatgtcac acaccaagcc ctacatcagg aagaaggctg 720 tgctgatcat gtacaaggtg ttcctgaagt accccgagtc gctgcgccct gcctttcccc 780 ggctgaagga gaagctggag gaccccgacc ccggggttca gtcggctgcc gtcaatgtca 840 tctgcgagct ggccagacgc aaccctaaga actacctgtc cctggccccg ctctttttca 900 agctgatgac gtcctccacc aacaactggg tcctcatcaa gatcatcaag ctgttcggtg 960 ctcttactcc tttggaaccg cggctgggca agaagctgat cgagcccctc accaatctca 1020 tccacagcac gtctgccatg tctctcctct atgaatgtgt gaacaccgtg attgcagtgc 1080 tcatctcgct gtcctccggc atgcccaacc acagcgccag catccagctt tgtgttcaga 1140 aattaaggat attgatcgag gactccgatc agaacttgaa gtacctgggg ctgctggcaa 1200 tgtccaagat cctgaagacc caccccaagt ccgtgcagtc ccacaaggac ctcatcctgc 1260 agtgcctgga cgacaaggac gagtccatcc ggctgcgggc cctggacctg ctctatggga 1320 tggtgtccaa gaagaacctg atggagatcg tgaagaagct gatgacccac gtagacaagg 1380 cagagggtac cacctaccgt gacgagctgc tcaccaagat cattgacatc tgcagccagt 1440 ccaactacca gtacatcacc aacttcgagt ggtacatcag catcctggtg gagctgaccc 1500 ggctggaggg cacacggcac ggccacctca tcgccgccca aatgctggac gtggccatcc 1560 gcgtgaaggc catccgcaag ttcgccgtgt cccagatgtc tgcgctgctt gacagtgcac 1620 acctgctggc cagcagcacc cagcggaacg ggatctgtga ggtgctgtac gctgccgcct 1680 ggatctgcgg ggagttctca gagcatctgc aggaaccaca ccacactttg gaggccatgc 1740 tgcggcccag agtcaccacg ctgccaggcc acatccaggc cgtgtatgtg cagaacgtgg 1800 tcaagctcta cgcctccatc ctgcagcaga aggagcaggc cggggaggca gagggcgctc 1860 aggccgtcac ccagctcatg gtggaccggc tgccccagtt tgtgcagagc gcagacctgg 1920 aggtgcagga gcgggcgtcc tgcatcctgc agctggtcaa gcacatccag aagcttcagg 1980 ccaaggacgt gcctgtggca gaggaggtca gcgctctctt tgctggggag ctgaacccag 2040 tggcccccaa ggcccagaag aaggttccag tccccgaagg cctggacctg gacgcctgga 2100 tcaatgagcc actctcggac agcgagtcag aggacgagag gcccagggcc gtcttccacg 2160 aggaggagca gcggcgtccc aagcaccggc cgtcggaggc ggacgaggaa gagctggctc 2220 ggcgccgaga ggcccggaag caggagcagg ccaacaaccc cttctacatc aagagctcgc 2280 catcgccaca gaagcggtac caggacaccc cgggcgtgga gcacattccc gtggtgcaga 2340 ttgacctctc cgtccccttg aaggttccag ggctgcctat gtcagatcag tatgtgaagc 2400 tggaggagga gcggcggcac cggcagaagc tggagaagga caagaggagg aaaaagagga 2460 aggagaagga gaagaagggc aagcgccgcc acagctcgct gcccacggag agcgacgagg 2520 acatcgcccc tgcccagcag gtggacatcg tcacagagga gatgcctgag aatgctctgc 2580 ccagcgacga ggatgacaaa gaccccaacg acccctacag ggctctggat attgacctgg 2640 ataagccctt agccgacagc gagaaactgc ctattcagaa acacagaaac accgagacct 2700 caaaatcccc tgagaaggac gttcccatgg tagaaaagaa gagcaagaaa cccaagaaga 2760 aagagaaaaa acacaaagag aaagagagag acaaggagaa gaagaaggag aaggagaaga 2820 agaaatctcc caagcctaag aagaagaagc acaggaagga gaaggaggag cggaccaaag 2880 gcaagaagaa gtccaagaag cagcctccag gcagcgagga ggcagcgggg gagccggtgc 2940 agaatggcgc gccagaggag gagcagctcc cgcctgagtc cagctactcc ctcctcgctg 3000 aaaattccta tgttaaaatg acctgtgaca tccggggcag tctgcaggag gacagccagg 3060 tcactgtggc catcgtgctg gagaacagga gcagcagcat cctcaagggc atggagctca 3120 gcgtgctgga ctcactcaat gccaggatgg cccggccgca gggctcctcc gtccacgatg 3180 gcgtccccgt gcctttccag ctgcccccag gcgtctccaa cgaagcccag tatgtgttca 3240 ccatccagag catcgtcatg gcgcagaagc tcaaggggac cctgtccttc attgccaaga 3300 atgacgaggg tgcgacccac gagaagctgg acttcaggct gcacttcagc tgcagctcct 3360 acttgatcac cactccctgc tacagtgacg cctttgctaa gttgctggag tctggggact 3420 tgagcatgag ctcaatcaaa gtcgatggca ttcggatgtc cttccagaat cttctggcga 3480 agatctgttt tcaccaccat ttttccgttg tggagcgagt ggactcctgc gcctccatgt 3540 acagccgctc catccagggc caccatgtct gcctcctggt gaaaaaggtg agaactctgt 3600 ctcagtcgac gggaagtgca gtgactccac gctactgagc aacttgttag aagagatgaa 3660 ggcgacgctg gccaagtgtt gagagctgcc tgcgagcccc gcaccacccc gcggagcacg 3720 tacccaggga ccgcagccct gacgtgtctc gcctctcctc agtcgtgtgt actgtaccca 3780 agcctgagtg ttaatttaac tctatgttgt ccgccgtgta gacatccgag gtcatttgtt 3840

gcgttgaatt atctgaccat ccttttttac tgtgactctt cccattctct ttggcaagaa 3900 gtccccttct cgcccccaaa ccagcaaggg actcccccac ctgggtctgt gccctgcccc 3960 gcgctggggg ccgagtcctt gaatgtggct tcaggggctc ctgtcctggg ccagggcctg 4020 atgggcacca cgtgaggggc acttggtgga cagggcgggg ctgacgtggc ctcctctggg 4080 gtcgcctgct tttgacccaa aggtcctgac ggttgcgtcc gggggagggg aaggaagggc 4140 cgctgtcgcc aaggttttct ctcccagaac ccacagtggg aaagcggtct tgccaggcgt 4200 tgtccattgt cagtgtgctc gtgggctggt gactgggtct tgggatccca ggccacgcgc 4260 cagccaggct gtgggcaggg cggggccagg gacgccaaag agaggttgca gtcagaaccg 4320 tggacggggt gggttgaggc ctctctgcca cccgtcttcc tggtcagcag aagtgcatct 4380 cggcttgggt ttggggtggt ccgcatcccc tgcttgccac tatgcgcacc aaggtttccc 4440 cacatccttc ccagcaccct taggaaggcc caggcagggc ctggaagcag cggacctggg 4500 ctgttctgtg ttgaaggagt gtgcccagtg cccttgggca ggacctgtga gagccacctc 4560 acaggcagag cccccaccag gcagggcaag gagactccgc tcactcccca cggccagcgt 4620 gggcacagga ctgacccttc ttcagagata atgacatttt atcttctcct tttgatgaaa 4680 actgtcactt tagcatgtaa tccattacag aatcccatgc agtgattcca ggatttgaaa 4740 ttgtatgatg tgttacataa gaatttattt gctatcgaca ttcccgtata aagagagaga 4800 catatcacgc tgctgtcatg attttgtgtc aagatgatcc aataaagttg taaaacaggc 4860 atttccaaaa aaaaaaaa 4878 <210> SEQ ID NO 38 <211> LENGTH: 964 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 38 gagtgccgta gcgcccggct cctgcagacg ctcggcctcc gctcattcct gaccccgcag 60 tgggcgcgat ggcggaggct gtactgaggg tcgcccggcg gcagctgagc cagcgcggcg 120 ggtctggagc ccccatcctc ctgcggcaga tgttcgagcc tgtgagctgc accttcacgt 180 acctgctggg tgacggagag tcccgggagg ccgttctgat cgacccagtc ctggaaacag 240 cgcctcggga tgcccagctg atcaaggagc tggggctgcg gctgctctat gctgtgaata 300 cccactgcca cgcggaccac attacaggct cggggctgct ccgttccctc ctccctggct 360 gccagtctgt catctcccgc cttagtgggg cccaggctga cttacacatt gaggatggag 420 actccatccg cttcgggcgc ttcgcgttgg agaccagggc cagccctggc cacaccccag 480 gctgtgtcac cttcgtcctg aatgaccaca gcatggcctt cactggagat gccctgttga 540 tccgtgggtg tgggcggaca gacttccagc aaggctgtgc caagaccttg taccactcgg 600 tccatgaaaa gatcttcaca cttccaggag actgtctgat ctaccctgct cacgattacc 660 atgggttcac agtgtccacc gtggaggagg agaggactct gaaccctcgg ctcaccctca 720 gctgtgagga gtttgtcaaa atcatgggca acctgaactt gcctaaacct cagcagatag 780 actttgctgt tccagccaac atgcgctgtg gggtgcagac acccactgcc tgatctcact 840 tctgtcagat gctcccatcc actattaatg cactaggtgg gaggagaggg cggcaatgac 900 actgcacctc tcctttccca ccgcattccc tggagctccc taaataaaac tttttttaac 960 gtga 964 <210> SEQ ID NO 39 <211> LENGTH: 3384 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 39 atggcccccg gggagaagat caaagccaaa atcaagaaga atctgcccgt gacgggccct 60 caggcgccga ccattaaaga gctgatgcgg tggtactgcc tcaacaccaa cacccatggc 120 tgtcgccgca tcgtggtgtc ccgcggccgt ctgcgccgcc tcctctggat cgggttcaca 180 ctgactgccg tggccctcat cctctggcag tgcgccctcc tcgtcttctc cttctatact 240 gtctcagttt ccatcaaagt ccacttccgg aagctggatt ttcctgcagt caccatctgc 300 aacatcaacc cctacaagta cagcaccgtt cgccaccttc tagctgactt ggaacaggag 360 accagagagg ccctgaagtc cctgtatggc tttccagagt cccggaagcg ccgagaggcg 420 gagtcctgga actccgtctc agagggaaag cagcctagat tctcccaccg gattccgctg 480 ctgatctttg atcaggatga gaagggcaag gccagggact tcttcacagg gaggaagcgg 540 aaagtcggcg gtagcatcat tcacaaggct tcaaatgtca tgcacatcga gtccaagcaa 600 gtggtgggat tccaactgtg ctcaaatgac acctccgact gtgccaccta caccttcagc 660 tcgggaatca atgccattca ggagtggtat aagctacact acatgaacat catggcacag 720 gtgcctctgg agaagaaaat caacatgagc tattctgctg aggagctgct ggtgacctgc 780 ttctttgatg gagtgtcctg tgatgccagg aatttcacgc ttttccacca cccgatgcat 840 gggaattgct atactttcaa caacagagaa aatgagacca ttctcagcac ctccatgggg 900 ggcagcgaat atgggctgca agtcattttg tacataaacg aagaggaata caacccattc 960 ctcgtgtcct ccactggagc taaggtgatc atccatcggc aggatgagta tccctccgtc 1020 gaagatgtgg gaacagagat tgagacaaca atggtcacct ctataggaat gcacctgaca 1080 gagtccttca agctgagtga gccctccagt cagtgcacgg agggcgggag tgacgtgcca 1140 atcaggaaca tctacaacgc tgcctactcg ctccagatct gccttcattc atgcttccag 1200 acaaagatgg tggagaaatg tgggtgtgcc cagtacagcc agcctctacc tcctgcagcc 1260 aactactgca actaccagca gcaccccaac tggatgtatt gttactacca actgcatcga 1320 gcctttgtcc aggaagagct gggctgccag tctgtgtgca aggaagcctg ccgctttaaa 1380 gagtggacac taaccacaag cctggcacaa tggccatctg tggtttcgga gaagtggttg 1440 ctgcctgttc tcacttggga ccaaggccgg caagtaaaca aaaagctcaa caagacagac 1500 ttggccaaac tcttgatatt ctacaaagac ctgaaccaga gatccatcat ggagagccca 1560 gccaacagta ttgagatgct tctgtccaac ttcggcggtc agctgggcct gtggatgagc 1620 tgctctgttg tctgcgtcat cgagatcatc gaggtcttct tcattgactt cttctctatc 1680 attgcccgcc gccagtggca gaaagccaag gagtggtggg cctggaaaca ggctccccca 1740 tgtccagaag ctccccgtag cccacagggc caggacaatc cagccctgga tatagacgat 1800 gacctaccca ctttcaactc tgctttgcac ctgcctccag ccctaggaac ccaagtgccc 1860 ggcacaccgc cccccaaata caataccttg cgcttggaga gggccttttc caaccagctc 1920 acagataccc agatgctgga tgagctctga ggcagggttg agaagacaga tctagtcagg 1980 accaccagcc atggtctaag gacatggatc gggtgccccc agacgtgtgc acaggggacc 2040 ctctgcccca ctctgggctt ttcagatact ctgaccaaaa agcctgcttt aaaccgcaag 2100 atggggcctg ggcatgcgca ggaggagcca tcgggtacta cgcagcaaca ctcacaactg 2160 tccaggctga gataaatccc gggacctgaa ctattagcac gtcactagag actgggagcc 2220 gaggcagtgg tgctggccca agtgaaggcc agagtgagga ctgatgcagc tctttacggg 2280 tcttgagagg gaaggactct tccaaagccc caaagccgag ggtttcaccc acactgccag 2340 cctgggttgg ggcccaagga tgtgaccttg agtgtcaagg ctggacagct actgccagat 2400 gccaaagata ggagaaagtg ccagccctga agctggagcc gcttgtgaat aaactgttct 2460 tcatcattga cactggagaa aggtgtcctc catgccctca ggcagcagag aactggccca 2520 gagcccttgg agtgttggtg gagatcagag tgccgtggtg gaggtctggg actatgtcag 2580 agtgtcctca ctttggggca tgggtggctc caggagatgg atttagttat tcaattttgt 2640 ggatgaataa attgaggcac agaaagatta agttaccggc ccaaggtgac acagtgagga 2700 ggtggcagag ctaggatttg accccagaca atctgacttc atgattgtgg catccaattc 2760 gtgtctgtgc ctcaatttgt gcaaacgact gtgtcacttt gcttggggag ggggagcatc 2820 ccacccacat gccctgggca ggtgacccaa gacagagctg acccctccac caccaaaggc 2880 ctgtctctca ccaacaagcc aactgctcac agatgaccca cttcatacca cattcacatc 2940 tggccacctg actccagcta tcaggtatta agtcccgggc agcgataagc ccccccacaa 3000 cagtgtgtta gctctgtctt agcaacctga taggttagca taggggctgc aaatgttgtt 3060 ccgccacacc aaatccctgt ttttgtccat gaactaagaa ttttatttta ttttattttt 3120 tattttttgt agaaatagga tctcactatg ttgcccaggc tgttcttgaa ctcctggcct 3180 caaatgatct tcccacttca gcctcccaaa gtgcagggat tacaggcaca agccaccgtg 3240 cccagccaag aatttttatt tttgctttta aatacccaaa gaagaagatt ctgtgactca 3300 tggaaatgat atgagattcg aattccagtg tctataaata aagttttatt ggtacacagc 3360 cccaaaaaaa aaaaaaaaaa aaaa 3384 <210> SEQ ID NO 40 <211> LENGTH: 6280 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 ggtgaaggac ctgggcagcc tcaatgggac gtttgtgaat gacatgcgca tcccggacca 60 gaagtacgtc acgctgaagc tcaacgatgt catccgcttt ggctacgatt ccaacatgta 120 tgtgctggag cgtgtgcagc accgagtccc ggaggaggca ctcaagcatg aaaagtacac 180 cagccagctg caggtgagcg tgaagggttt ggcgcccaag aggagcgagg cactgccgga 240 acacacacca tactgcgagg cctcgaaccc caggccggag aagggggacc ggagaccagg 300 aacagaggca gcctcttacc gcacacccct gtatgggcag ccctcctggt ggggtgagga 360 cgatggtagc acgctgcctg atgcccagcg ccagggagag ccctacccag agcgccccaa 420 gggacccgtg cagcaggacg gggagctcca cggcttccgc gcccctgctg agcctcaggg 480 ctgctcgttc cggcgggagc ccagctactt cgagatcccc acgaaggaga ccccgcagcc 540 gtcgcagccc cccgaggtgc cggcacacga gatgcccacg aaggatgcag aggcaggtgg 600 gggcggagcg gcccctgtgg tgcagagcca cgcctccttc accatcgagt ttgatgactg 660 cagccctggc aagatgaaga tcaaggacca tatcaccaag ttttccctgc gccagcggcg 720 gcccccgggc aaggaggcca cacctggcga gatggtgtcg gctgagacca aggtggccga 780 ctggctggtg cagaatgacc cgagcctgct gcaccgggtt ggccctgggg atgaccgcca 840 cagcaccaag agcgacctgc ctgtccacac ccgcaccctg aagggccaca agcacgagga 900 cggcacgcag agtgactcag aggaccccct ggccaaggcg gcctcggccg ctggggtgcc 960 cttggaggcc agcggggggc aggtgcggct gcagaggcag atcaagcggg acccccagga 1020 gctactacat aaccagcagg cctttgtcat cgagttcttc gacgaggaca cgccccgaaa 1080 gaagcgctcc cagtccttca cgcacagccc gtccggggac cccaaggccg acaagcgccg 1140 tggcccaacg ccggccgata gggaccgccc cagtgtccca gccccagtcc aggcaggggg 1200 ccgcagctcg gggccacaga gggccggctc gctcaagcgg gagaagacag aggaacggct 1260

gggcagcccc tcgcccgcct cccgaacccc tgcccgcccc ttcggaagcg tggggcgccg 1320 ctcccgcctg gcccaggact tcatggccca gtgtctgcgg gagagctccc cggccgcccg 1380 gcccagcccc gagaaggttc ctccggtgct gcccgctccc ctgacacccc atgggaccag 1440 ccccgtgggc cccccgaccc caccgcccgc ccccacggac ccccagctga ccaaggcacg 1500 gaaacaggag gaggatgaca gcctcagtga cgcagggaca tacaccatcg agaccgaggc 1560 gcaggacacg gaggtggagg aggctcggaa gatgatcgac caggtctttg gggtgttgga 1620 gtcccctgaa ctctccaggg catcttcggc cacctttcgc ccagtcatca gaggggacag 1680 agatgagtct gatgacgggg gcgtggccca gcggatggcg ctactgcagg agtttgcctc 1740 ccggccactg ggtgcggccc cccaggcgga gcaccagggc ctcccggtgc cgggctcccc 1800 tgggggtcag aagtgggtgt cccgctgggc cagcctggct gacagctact cagacccggg 1860 cctcacagag gatggcctgg gacgtagagg cggggagccg gaggggtccc tgcctgtgcg 1920 catgcggcga cggctccctc agctgcccag tgagagggct gacagccctg cgggcccaga 1980 gagcagcagg aggagtgggc ctgggccacc ggagctggac agtgagcagc ccagccgcct 2040 cttcggccag gaggagttgg atcctgacag cctcagcgat gccagtgggt cggacggggg 2100 ccgaggcccc gagccagggg tggagccaca ggacagcaga cgcaggagcc cccaggaggg 2160 gcccacgtgg agcaggggtc ggcgctcacc aagggccccc ggggagccaa ctcccgcctc 2220 tttcttcatt ggggaccaga atggggacgc tgtgttatct aggaaactgc ttgcggctcc 2280 aggggatggg gagggcctag ggcagacagc ccagcccagc cccccagcac gggatggcgt 2340 ctatgtcagt gccaatggga gaatggtcat ccagctacgg cctggacggt ccccagaacc 2400 cgacggccct gccccagcct ttctccggca agagagcttc actaaggagc cagccagtgg 2460 tcccccagcg cccggcaagc ccccccacat ctccagccac ccgcttctac aggacctggc 2520 cgctacccgg gccgcacgca tggacttcca ctcccaggac acccacctga tcttgaagga 2580 gacggagacg gccctggcgg ccctggaggc ccgactcctc tctaattctg tggatgccga 2640 gtgtgagggg ggcagcaccc cgaggccgcc ggaggacgcc ctgtctgggg actcggacgt 2700 ggacacagcc agcaccgtca gcctgcgtag tggcaagagc gggcccagcc ccacaacccc 2760 ccagcctctg cgggcacaga aggagatgtc gccatccccg ccagctgcac aggacccggg 2820 aggcaccgcc ctggtcagtg cccgtgagca gtcctcagag aggcagcatc acccacttgg 2880 cccgacggac atgggccgtg gagagccggt acggcgctca gccataaggc gtggccacag 2940 gccccgaggg tccctggatt ggcccagtga ggagcgtggc cctgtcctcg cccacctacc 3000 cagctcagat gtgatggcct ccaaccacga aacccctgag gccaccgggg caggacggct 3060 aggttctcgc cggaaaccag cggccccacc gccatcccca gctgcccggg aggagcagag 3120 ccgtagctca gccagctccc agaaggggcc gcaggccttg acccgctcca acagcctgtc 3180 cacccctcgc cccacacggg cctcccggct gaggcgggcc cggctggggg acgcttcaga 3240 cactgaggct gcggatggtg agcgggggtc cctgggcaac cctgagcccg tgggccggcc 3300 agctgctgag caggccaaga agctgtcacg cctggacatc ctggccatgc cccggaagcg 3360 ggccggctcc ttcacaggga ctagtgaccc cgaggcagcc cctgcccgca ccagcttctc 3420 tggccgcagt gtggagttgt gctgtgccag ccgcaagccc accatggccg aagcacgggc 3480 tgtctccagg aaggctgcca acacagccac caccacgggt ccccgccagc ccttcagcag 3540 ggcccgctcg ggcagtgccc gatacacctc caccactcag accccgaggg ctggcagctc 3600 cagccgggct cgttcccggg cccccggccc ccgggacacg gacgacgatg aggaggagcc 3660 tgacccttat ggtttcatcg tgcagacggc agagattgcg gagattgcca ggctgagcca 3720 gacgctggtg aaggacgtgg ccatcctagc ccaggagatc cacgatgtgg ctggggacgg 3780 tgacacactg ggctcctcgg agcctgccca cagcgcctcc ctcagcaaca tgcccagcac 3840 ccccgcctcg accatctctg cccgggagga gctggtgcag cgcatccccg aggccagcct 3900 caacttccag aaggtgccgc ccggctcgct gaactctcgg gactttgacc agaacatgaa 3960 cgacagctgt gaggacgccc tggccaacaa gacgcggcct cggaaccgag aggaggtgat 4020 cttcgataac ctgatgctga acccggtgtc ccagctgtcg caggccatcc gtgagaacac 4080 agagcacctt gccgagaaga tgaagatcct ctttcagaac acagggagag cttgggagga 4140 cctggaagcc aggatcaacg ccgagaacga ggtgcccatc ctgaagacat ctaacaagga 4200 aatcagctcc atcctgaagg aactgaggcg ggtgcagaaa cagctggaag ttatcaatgc 4260 catcgtggac cccagtggga gcctggacct gctcacagga aacaggagct tggccagctc 4320 tgcacagccg gggctgggga agggccgcgt ggctgcccag agcccaccct cacccgcctc 4380 agccgaggcc ctgctgccag ccctgcccct gaggaatttc ccacagcggg ccagctgtgg 4440 gcctcccagc ctcccggacc ccaccttcct ccctgatgcc gagaggttcc tgatctaggc 4500 cccagacctg gccaggccag cctccctgtg cgtgtgcgtc tctgccttcc gtccgccgca 4560 cacccgcctg cctggccgca ggtggttctc cctgaagacc cccacatgtg ccatatccct 4620 gtgggcgggt gcctcccacg cccttgcccc ctcgtcagct cccagccagc accctactca 4680 ccctgtccag ccccatggcc acccccaccc ctgcctcgcc ccctacaggc ctctgggccc 4740 agctcctggc caggctgctg ccaaggtcaa gccctcaagg gcattacccc gcctcctctt 4800 catcactgtt atttttgtct ttagctttaa aggaaagagt tgttggtgcc attgcaggtg 4860 ccccctccag gcctgactgg ctccgccagg cactaacctg ccataaccct ttgtgctggc 4920 ctgcggccag gcagaggaag agaggtcgac tgtggggtca tttggtgcca aacatggagg 4980 tgggcaggct cacctgttcc tgggactgtc tgagatggca gggcacttgc cctggtggct 5040 cccacctgac cccaggcctt ttataggcag gagccccact gcttccagcc tctggtgcca 5100 acacagttgc caaacccatt gagcttgggg ctgccccgtg gaggcctcct gggtatggac 5160 caggggcttg ttgagagctg agccatgcac acaggtgcag acacccccca actcccatgc 5220 acacggctag tccaggcgcc tccacgctgc accgtgagga ctgcagggca tgtccccgtg 5280 aggggctatg ggcctctgta ggtgggcttc caaggtcctg ggtgcagccg ggtgcatggc 5340 agcccttctg gcgggggtga gcgcacgacc aaagtcactg gaagccgggt ttccggaagc 5400 tcgcagcttg gcctgcacca cacgccctcc ccttttggct tcacgccatc aggcctcaag 5460 tgggcatggg ggcagggacg ggcccaggaa ctgttgtttt ctcaggattc tttcagctgg 5520 gaacatggca ggtgagcaga gcttggtgcc tctgccgtgg cccctgctgg ggcagcccgt 5580 gttgccggag cctctaagcc aaagagcccg ttggccgtgg ttggtggggg tggacgtggg 5640 ggtgtcccac ctggaccaga ctggcgtggg tgagctccac accctgcctg gcaatggtat 5700 gagagtcgga cctggacagg gccagctgct gggggagcgg cactggggac tggaggctgg 5760 aagcgggtgg tgtgtgtccc ctgtttactt ttagctgagc tggggttggg tgtacgggtt 5820 ctgttcctct gagccctgcg gcccacctga tgtttacgtg tgtgtgtgag ggggggcggg 5880 ggtggcaggt gtccccccct ggtccccgcc ccaagagcct gctgtctgta tggaggaggt 5940 gctagcccgg tccaccgggc tgctgcccac ccctgcatgc cccagttgcc caccccgcct 6000 gcccctggac atgaagtggt cacgcttcat ccacggctcc ttcccacccc tcggcagtgg 6060 ctgtgcaatg ttttaagttc acaagttcct gctcctcccc acactgagct cctttgttcc 6120 tccccctcca gcctttgcct gggaactggt ccttgtttgc cgggcttctc ggagggttca 6180 ctgtacattc gttctcaggt ggtcttgtgg ctgtctttcg gaaaatggtt attttatatg 6240 atttgtcatg gaatttgttc taataaatca ttcttctatc 6280 <210> SEQ ID NO 41 <211> LENGTH: 2782 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 41 gcgacgccga gtttcactct ggctgccttc tcctgagagt cggagccaca gccagagccc 60 tgcccaggcc gagccggagc tgcagcccga gcgcggtggt gccctcagcc ccgtcctctt 120 gtcctcctca gcctcggtgc cttggaattt gtgtcgctga gtcagcaagc ctttcagatt 180 tgcccggttt ttgttgtttg tggtttgtat caagatggga actcaaacaa gtcattcctc 240 ctaaggagct ggtgtcttca tccagaaggg acagtttgtg ccagctctcc agagagaaaa 300 ggatctggta ctgttctgga gtggcctgta gcagacactg aaccaccagc cagctgcatt 360 tgttgtcctg gaagtcattg ccaactctgc cagtcacact ggggtcccca aagaagtcaa 420 gatctgccgg aggcgctggg caatgacccc gggactccag gccagagggg tctgaagctg 480 tttgggaaag cagcgggact ccttgggaag atggccatgg ccccaagccc ttccctggtg 540 caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc 600 tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag 660 ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc 720 tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc 780 accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc 840 gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac 900 tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac 960 aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttttgccgc 1020 agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc 1080 cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg 1140 tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc 1200 ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc 1260 tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct 1320 cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag 1380 cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc 1440 tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga 1500 gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg 1560 tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt 1620 cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag 1680 ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag 1740 gactgcatca tctgcatgga gaagctgtcc gcagcgtctg gatacagcga tgtgactgac 1800 agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac 1860 ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc 1920 tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta 1980 ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac 2040 agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc 2100 agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag 2160 ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg 2220 ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac 2280

attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct 2340 gcccaggggg tgaccgagga ctgcctggag cagcagtgac ctcgcacccc agcacgcccg 2400 cctctggtgg ccaccccgct gccccatggc tggctgggtg gccaggcagg aagtgcccag 2460 cccgagaggc tgggaggttt gttgagggtg tggggtgtgc cccacctgaa gccggggctc 2520 cccctgcctg cctctctctc ctcctcccct ctgggaattg ggcagccctg ggcagttgta 2580 ctcatggggg cttaggatgc agctacctca gtgcgcaggg cccgtctgtc ctctgggggc 2640 tgcttcgggc ccgcggtgct cggggcctgg tgtggggcga gtagagactt ccccagcctg 2700 gacgggcgtg ggttctgggt cagcttcttt tacctcaatt ttgtttgcaa taaatgctct 2760 atagccaaaa aaaaaaaaaa aa 2782 <210> SEQ ID NO 42 <211> LENGTH: 2124 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 42 gctccgcaat catcttcttt accctggagc tgctgctgct gctgctgctt ttgcttttgg 60 ggctgagttt aataagcgag cgagcgagca agcgagcgcg gggggaaaaa ggcagagaat 120 gtccgccatc taccctccgc tcctgggcgc gctctcattc atagcagcct cttcatgaat 180 tacagctgag ggggggcgga ggaggggggg gtaccacaca acaccccagc aaacctccgg 240 gcccccaggc atggctagct cgtgtgccgt gcaggtgaag ctggagctgg ggcaccgcgc 300 ccaggtgagg aaaaaaccca ccgtggaggg cttcacccac gactggatgg tgttcgtacg 360 cggtccggag cacagtaaca tacagcactt tgtggagaaa gtcgtcttcc acttgcacga 420 aagctttcct aggccaaaaa gagtgtgcaa agatccacct tacaaagtag aagaatctgg 480 gtatgctggt ttcattttgc caattgaagt ttattttaaa aacaaggaag aacctaggaa 540 agtccgcttt gattatgact tattcctgca tcttgaaggc catccaccag tgaatcacct 600 ccgctgtgaa aagctaactt tcaacaaccc cacagaggac tttaggagaa agttgctgaa 660 ggcaggaggg gaccctaata ggagtattca taccagcagc agcagcagca gcagcagtag 720 cagcagcagc agcagcagca gcagcagcag tagcagcagc agcagcggca gcagcagcag 780 cagtagcagc agcagtagca gcagcagcag cagcagtagt accagttttt caaagcctca 840 caaattaatg aaggagcaca aggaaaaacc ttctaaagac tccagagaac ataaaagtgc 900 cttcaaagaa ccttccaggg atcacaacaa atcttccaaa gaatcctcta agaaacccaa 960 agaaaataaa ccactgaaag aagagaaaat agttcctaag atggccttca aggaacctaa 1020 acccatgtca aaagagccaa aaccagatag taacttactc accatcacca gtggacaaga 1080 taagaaggct cctagtaaaa ggccgcccat ttcagattct gaagaactct cagccaaaaa 1140 aaggaaaaag agtagctcag aggctttatt taaaagtttt tctagcgcac caccactgat 1200 actcacttgt tctgctgaca aaaaacagat aaaagataaa tctcatgtca agatgggaaa 1260 ggtcaaaatt gaaagtgaga catcagagaa gaagaaatca acgttaccgc catttgatga 1320 tattgtggat cccaatgatt cagatgtgga ggagaatata tcctctaaat ctgattctga 1380 acaacccagt cctgccagct ccagctccag ctccagctcc agcttcacac catcccagac 1440 caggcaacaa ggtcctttga ggtctataat gaaagatctg cattctgatg acaatgagga 1500 ggaatcagat gaagtggagg ataacgacaa tgactctgaa atggagaggc ctgtaaatag 1560 aggaggcagc cgaagtcgca gagttagctt aagtgatggc agcgatagtg aaagcagttc 1620 tgcttcttca cccctacatc acgaacctcc accaccctta ctaaaaacca acaacaacca 1680 gattcttgaa gtgaaaagtc caataaagca aagcaaatca gataagcaaa taaagaatgg 1740 tgaatgtgac aaggcatacc tagatgaact ggtagagctt cacagaaggt taatgacatt 1800 gagagaaaga cacattctgc agcagatcgt gaaccttata gaagaaactg gacactttca 1860 tatcacaaac acaacatttg attttgatct ttgctcgctg gacaaaacca cagtccgtaa 1920 actacagagt tacctggaaa catctggaac atcctgagga tataacaact ggatgcatca 1980 agaactattg tgtttttttt ttttggtttt tttttttttt tggttgtgat tttttgttct 2040 tgttgtttat atgaaaacac tcaaaatgat gcaaccaaaa gggaaaaaat aaaaatcaaa 2100 caacctccaa aaaaaaaaaa aaaa 2124 <210> SEQ ID NO 43 <211> LENGTH: 1539 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 43 gaattcgggg ggagggggca gtgtcctccg agccaggaca ggcatgttgt tgggactggc 60 ggccatggag ctgaaggtgt gggtggatgg catccagcgt gtggtctgtg gggtctcaga 120 gcagaccacc tgccaggaag tggtcatcgc actagcccaa gcaataggcc agactggccg 180 ctttgtgctt gtgcagcggc ttcgggagaa ggagcggcag ttgctgccac aagagtgtcc 240 agtgggcgcc caggccacct gcggacagtt tgccagcgat gtccagtttg tcctgaggcg 300 cacagggccc agcctagctg ggaggccctc ctcagacagc tgtccacccc cggaacgctg 360 cctaattcgt gccagcctcc ctgtaaagcc acgggctgcg ctgggctgtg agccccgcaa 420 aacactgacc cccgagccag cccccagcct ctcacgccct gggcctgcgg cccctgtgac 480 acccacacca ggctgctgca cagacctgcg gggcctggag ctcagggtgc agaggaatgc 540 tgaggagctg ggccatgagg ccttctggga gcaagagctg cgccgggagc aggcccggga 600 gcgagaggga caggcacgcc tgcaggcact aagtgcggcc actgctgagc atgccgcccg 660 gctgcaggcc ctggacgctc aggcccgtgc cctggaggct gagctgcagc tggcagcgga 720 ggcccctggg cccccctcac ctatggcatc tgccactgag cgcctgcacc aggacctggc 780 tgttcaggag cggcagagtg cggaggtgca gggcagcctg gctctggtga gccgggccct 840 ggaggcagca gagcgagcct tgcaggctca ggctcaggag ctggaggagc tgaaccgaga 900 gctccgtcag tgcaacctgc agcagttcat ccagcagacc ggggctgcgc tgccaccgcc 960 cccacggcct gacaggggcc ctcctggcac tcagggccct ctgcctccag ccagagagga 1020 gtccctcctg ggcgctccct ctgagtccca tgctggtgcc cagcctaggc cccgaggtgg 1080 cccccatgac gcagaactcc tggaggtagc agcagctcct gccccagagt ggtgtcctct 1140 ggcagcccag ccccaggctc tgtgacagcc tagtgagggc tgcaagacca tcctgcccgg 1200 accacagaag gagagttggc ggtcacagag ggctcctctg ccaggcagtg ggaagccctg 1260 ggtttggcct caggagctgg gggtgcagtg ggggactgcc ctagtccttg ccaggtcgcc 1320 cagcaccctg gagaagcatg gggcgtagcc agctcggaac ttgccaggcc ccaaaggcca 1380 cgactgcctg ttggggacag gagatgcatg gacagtgtgc tcaagctgtg ggcatgtgct 1440 tgcctgcggg agaggtcctt cactgtgtgt acacagcaag agcatgtgtg tgccacttcc 1500 cctaccccaa cgtgaaaacc tcaataaact gcccgaagc 1539 <210> SEQ ID NO 44 <211> LENGTH: 1514 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 44 cgcgcctgcc tctttctgag cggcatgaag ccacctccca ggcggcgagc ggccccggcg 60 cgctatctgg gcgaggtgac cggtcccgcg acctggagcg ctcgcgagaa gcggcagcta 120 gtgcgactcc tgcaggcgcg gcagggccag ccggagccgg acgccaccga gctggcccgg 180 gagctgcggg gccggagcga ggctgagatc cgggtcttcc tccagcagct caagggccgc 240 gtagcccggg aggccattca gaaagtgcat ccgggtggcc ttcagggacc aaggcgccgg 300 gaggcacagc ccccagcccc catagaggtc tggacggatc tggctgagaa gataacaggg 360 ccactggaag aagccctggc agtggctttc tcgcaggtgc tcaccatcgc ggccacggaa 420 ccggtcaccc tcctgcactc caagcccccc aagcccacgc aggcccgtgg aaagcctttg 480 ctcctgagcg cccctggagg acaggaagac cccgcccctg aaatacctag ctctgcccct 540 gctgcaccta gctccgcacc caggactcct gaccctgccc ctgagaaacc ttctgagtcg 600 tcggctggtc cctccactga agaagacttt gctgtggact ttgagaagat ctacaagtac 660 ttgtcctctg tctcccgaag tggccgcagc cccgagctct cagcagctga gtccgctgtg 720 gtcctcgacc tgctcatgtc acttccagag gagctgccac tcctgccctg cacagccctg 780 gttgagcata tgacggagac gtacctacgc ctgacagccc cccagcccat tcccgctgga 840 gggagcctgg ggcctgcagc agaaggggat ggggctggct ccaaggcacc agaggagacc 900 cccccagcca ccgagaaggc cgagcacagc gaactgaaat cgccttggca agcagctggg 960 atctgtcccc tgaacccgtt cctggtgccc ctggagcttc tgggtcgggc agccacccct 1020 gccaggtgag gggcatggcg ggcaggaggc cacaccaggc cccccgccct gcccctcggt 1080 tctgctcggc tggccctggc tctttctgag gatcccgtca tgggggaagg tccttgagat 1140 gatgctcagc tgtggggcgg gcctctaaga tgccccatac tttgggggtc tcagaaatgg 1200 aacccccgtt gtacaggggt tgggtggggg ttgcaggact ccactcacaa gcctcctgat 1260 gtcaaggaca ggcggacagg gctggcctcc cccagtcccc aagccccact gtgccttgtt 1320 gtctgctggg gggccatagc tggcactgcc caccgtaaag gccctcgcac attttccccc 1380 ttcctgtaca cctcggggcc agcatcctca ccttcttcaa ctgaccagtc gtggttactc 1440 cctgctgcca ggtccttccc cttcccgggg gtattctgtg accatgaata aagttaccat 1500 tctctttctc tttc 1514 <210> SEQ ID NO 45 <400> SEQUENCE: 45 000 <210> SEQ ID NO 46 <211> LENGTH: 2744 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 ctcgtgccga attcggcacg agaccgcgtg ttcgcgcctg gtagagattt ctcgaagaca 60 ccagtgggcc cgtgtggaac caaacctgcg cgcgtggccg ggccgtggga caacgaggcc 120 gcggagacga aggcgcaatg gcgaggaagt tatctgtaat cttgatcctg acctttgccc 180 tctctgtcac aaatcccctt catgaactaa aagcagctgc tttcccccag accactgaga 240 aaattagtcc gaattgggaa tctggcatta atgttgactt ggcaatttcc acacggcaat 300 atcatctaca acagcttttc taccgctatg gagaaaataa ttctttgtca gttgaagggt 360 tcagaaaatt acttcaaaat ataggcatag ataagattaa aagaatccat atacaccatg 420 accacgacca tcactcagac cacgagcatc actcagacca tgagcgtcac tcagaccatg 480 agcatcactc agaccacgag catcactctg accataatca tgctgcttct ggtaaaaata 540

agcgaaaagc tctttgccca gaccatgact cagatagttc aggtaaagat cctagaaaca 600 gccaggggaa aggagctcac cgaccagaac atgccagtgg tagaaggaat gtcaaggaca 660 gtgttagtgc tagtgaagtg acctcaactg tgtacaacac tgtctctgaa ggaactcact 720 ttctagagac aatagagact ccaagacctg gaaaactctt ccccaaagat gtaagcagct 780 ccactccacc cagtgtcaca tcaaagagcc gggtgagccg gctggctggt aggaaaacaa 840 atgaatctgt gagtgagccc cgaaaaggct ttatgtattc cagaaacaca aatgaaaatc 900 ctcaggagtg tttcaatgca tcaaagctac tgacatctca tggcatgggc atccaggttc 960 cgctgaatgc aacagagttc aactatctct gtccagccat catcaaccaa attgatgcta 1020 gatcttgtct gattcataca agtgaaaaga aggctgaaat ccctccaaag acctattcat 1080 tacaaatagc ctgggttggt ggttttatag ccatttccat catcagtttc ctgtctctgc 1140 tgggggttat cttagtgcct ctcatgaatc gggtgttttt caaatttctc ctgagtttcc 1200 ttgtggcact ggccgttggg actttgagtg gtgatgcttt tttacacctt cttccacatt 1260 ctcatgcaag tcaccaccat agtcatagcc atgaagaacc agcaatggaa atgaaaagag 1320 gaccactttt cagtcatctg tcttctcaaa acatagaaga aagtgcctat tttgattcca 1380 cgtggaaggg tctaacagct ctaggaggcc tgtatttcat gtttcttgtt gaacatgtcc 1440 tcacattgat caaacaattt aaagataaga agaaaaagaa tcagaagaaa cctgaaaatg 1500 atgatgatgt ggagattaag aagcagttgt ccaagtatga atctcaactt tcaacaaatg 1560 aggagaaagt agatacagat gatcgaactg aaggctattt acgagcagac tcacaagagc 1620 cctcccactt tgattctcag cagcctgcag tcttggaaga agaagaggtc atgatagctc 1680 atgctcatcc acaggaagtc tacaatgaat atgtacccag agggtgcaag aataaatgcc 1740 attcacattt ccacgataca ctcggccagt cagacgatct cattcaccac catcatgact 1800 accatcatat tctccatcat caccaccacc aaaaccacca tcctcacagt cacagccagc 1860 gctactctcg ggaggagctg aaagatgccg gcgtcgccac tttggcctgg atggtgataa 1920 tgggtgatgg cctgcacaat ttcagcgatg gcctagcaat tggtgctgct tttactgaag 1980 gcttatcaag tggtttaagt acttctgttg ctgtgttctg tcatgagttg cctcatgaat 2040 taggtgactt tgctgttcta ctaaaggctg gcatgaccgt taagcaggct gtcctttata 2100 atgcattgtc agccatgctg gcgtatcttg gaatggcaac aggaattttc attggtcatt 2160 atgctgaaaa tgtttctatg tggatatttg cacttactgc tggcttattc atgtatgttg 2220 ctctggttga tatggtacct gaaatgctgc acaatgatgc tagtgaccat ggatgtagcc 2280 gctgggggta tttcttttta cagaatgctg ggatgctttt gggttttgga attatgttac 2340 ttatttccat atttgaacat aaaatcgtgt ttcgtataaa tttctagtta aggtttaaat 2400 gctagagtag cttaaaaagt tgtcatagtt tcagtaggtc atagggagat gagtttgtat 2460 gctgtactat gcagcgttta aagttagtgg gttttgtgat ttttgtattg aatattgctg 2520 tctgttacaa agtcagttaa aggtacgttt taatatttaa gttattctat cttggagata 2580 aaatctgtat gtgcaattca ccggtattac cagtttatta tgtaaacaag agatttggca 2640 tgacatgttc tgtatgtttc agggaaaaat gtctttaatg ctttttcaag aactaacaca 2700 gttattccta tactggattt taggtctctg aagaactgct ggtg 2744 <210> SEQ ID NO 47 <211> LENGTH: 1759 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 47 agcggatgct ggggctgtaa ggcgcgcgcg gtcagctgtt ggcggtgcag ggaggaggac 60 gccggggctc gccttccctc ctctgccgcc gctgccgcca tgattccggt gtcgctggtg 120 gtggtggtgg tgggtggctg gactgtcgtc tacctgaccg acttggtgct gaagtcatct 180 gtctatttta aacattctta tgaagactgg ctggaaaaca acggactgag catctcccct 240 ttccacataa gatggcaaac tgctgttttc aatcgtgcct tttacagttg gggacggcgg 300 aaagcaagga tgctttacca atggttcaat tttggaatgg tgtttggcgt aattgccatg 360 tttagctcat tttttctcct tggaaaaacg ctgatgcaga ctttggcaca aatgatggct 420 gactctccct cttcttattc ttcctcctct tcttcctctt cctcctcttc ttcctcttcc 480 tcttcttcat cttcttcctc ttcctcgctt cacaatgaac aggtgttaca agttgtggtt 540 cctggtataa atttacccgt caatcaactg acctatttct tcacggcagt tctcattagt 600 ggtgttgtac atgaaattgg acatgggata gcagctatta gggaacaagt tcgatttaat 660 ggctttggga tttttctctt cattatttat cctggagcat ttgttgatct gttcaccact 720 catttgcaac ttatatcgcc agtccagcag ctaaggatat tttgtgcagg tatctggcat 780 aattttgtcc ttgcactctt gggtatttta gctcttgttc tcctcccagt aattctcttg 840 ccattttact acactggagt tggggtgctc atcactgaag ttgctgagga ctctcctgcc 900 attggaccca gaggcctttt tgtgggagac cttgtcaccc atctacagga ttgtcctgtt 960 actaatgtgc aagattggaa tgaatgttta gataccatcg cctatgagcc ccaaattggt 1020 tactgtataa gtgcatcaac tttacagcag ttaagtttcc cagttagagc atacaaacga 1080 ctagatggtt caactgaatg ctgtaacaat cacagcctca cagatgtgtg cttttcctac 1140 agaaataatt ttaataagcg tttgcataca tgtcttcctg cccggaaagc agttgaagca 1200 actcaagttt gcagaaccaa taaagactgt aaaaaaagct caagttcaag tttctgtata 1260 ataccttctt tggaaactca cactcgctta ataaaagtaa aacacccacc tcagattgat 1320 atgttatacg taggacatcc tctgcatctt cactacacag tgagcatcac cagttttatc 1380 ccacgtttta actttctaag catagatctg ccagtggttg tggagacatt tgtcaagtac 1440 ctgatttccc tctcaggagc tctggctatt gttaatgcag taccctgctt tgctttggat 1500 ggacaatgga ttctaaactc tttcttggat gccaccctta cctcagtgat tggagacaat 1560 gatgtcaaag atctaatagg gtttttcatc ttgctgggtg gcagtgtact tttggctgcc 1620 aatgtgaccc tgggactctg gatggttaca gcacggtaat gtttgcactc atctgacaga 1680 atccctgagt tacagtatac agctatgtgg taatattcat tgccattgaa attcttactt 1740 ggtatgaaat ataaagtgt 1759 <210> SEQ ID NO 48 <211> LENGTH: 1610 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 48 ggcacgaggc tgcggccgca gtagccggag ccggagccgc agccaccggt gccttccttt 60 cccgccgccg cccagccgcc gtccggcctc cctcgggccc gagcgcagac caggctccag 120 ccgcgcggcg ccggcagcct cgcgctccct ctcgggtctc tctcgggcct cgggcaccgc 180 gtcctgtggg cggccgcctg cctgcccgcc cgcccgcagc cccttgcctg ccggcccctg 240 ggcggcccgt gccatgggca ccgacagccg cgcggccaag gcgctcctgg cgcgggcccg 300 caccctgcac ctgcagacgg ggaacctgct gaactggggc cgcctgcgga agaagtgccc 360 gtccacgcac agcgaggagc ttcatgattg tatccaaaaa accttgaatg aatggagttc 420 ccaaatcaac ccagatttgg tcagggagtt tccagatgtc ttggaatgca ctgtatctca 480 tgcagtagaa aagataaatc ctgatgaaag agaagaaatg aaagtttctg caaaactgtt 540 cattgtagaa tcaaactctt catcatcaac tagaagtgca gttgacatgg cctgttcagt 600 ccttggagtt gcacagctgg attctgtgat cattgcttca cctcctattg aagatggagt 660 taatctttcc ttggagcatt tacagcctta ctgggaggaa ttagaaaact tagttcagag 720 caaaaagatt gttgccatag gtacctctga tctagacaaa acacagttgg aacagctgta 780 tcagtgggca caggtaaaac caaatagtaa ccaagttaat cttgcctcct gctgtgtgat 840 gccaccagat ttgactgcat ttgctaaaca atttgacata cagctgttga ctcacaatga 900 tccaaaagaa ctgctttctg aagcaagttt ccaagaagct cttcaggaaa gcattcctga 960 cattcaagcg cacgagtggg tgccgctgtg gctactgcgg tattcggtca ttgtgaaaag 1020 tagaggaatt atcaaatcaa aaggctacat tttacaagct aaaagaaggg gttcttaact 1080 gacttaggag cataacttac ctgtaatttc cttcaatatg agagaaaatt gagatgtgta 1140 aaatctagtt actgcctgta aatggtgtca ttgaggcaga tattctttcg tcatatttga 1200 cagtatgttg tctgtcaagt tttaaatact tatcttgcct ccatatcaat ccattctcat 1260 gaacctctgt attgctttcc ttaaactatt gttttctaat tgaaattgtc tataaagaaa 1320 atacttgcaa tatatttttc ctttattttt atgactaata taaatcaaga aaatttgttg 1380 ttagatatat tttggcctag gtatcagggt aatgtatata catatttttt atttccaaaa 1440 aaaattcatt aattgcttct taactcttat tataaccaag caatttaatt acaattgtta 1500 aaactgaaat actggaagaa gatatttttc ctgtcattga tgagatatat cagagtaact 1560 ggagtagctg ggatttacta gtagtgtaaa taaaattcac tcttcaatac 1610 <210> SEQ ID NO 49 <211> LENGTH: 2044 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 49 ctggacgagt ccgagcgcgt cacctcctca cgctgcggct gtcgcccgtg tcccgccggc 60 ccgttccgtg tcgccccgca gtgctgcggc cgccgcggca ccatggctgt gtttgtcgtg 120 ctcctggcgt tggtggcggg tgttttgggg aacgagttta gtatattaaa atcaccaggg 180 tctgttgttt tccgaaatgg aaattggcct ataccaggag agcggatccc agacgtggct 240 gcattgtcca tgggcttctc tgtgaaagaa gacctttctt ggccaggact cgcagtgggt 300 aacctgtttc atcgtcctcg ggctaccgtc atggtgatgg tgaagggagt gaacaaactg 360 gctctacccc caggcagtgt catttcgtac cctttggaga atgcagttcc ttttagtctt 420 gacagtgttg caaattccat tcactcctta ttttctgagg aaactcctgt tgttttgcag 480 ttggctccca gtgaggaaag agtgtatatg gtagggaagg caaactcagt gtttgaagac 540 ctttcagtca ccttgcgcca gctccgtaat cgcctgtttc aagaaaactc tgttctcagt 600 tcactccccc tcaattctct gagtaggaac aatgaagttg acctgctctt tctttctgaa 660 ctgcaagtgc tacatgatat ttcaagcttg ctgtctcgtc ataagcatct agccaaggat 720 cattctcctg atttatattc actggagctg gcaggtttgg atgaaattgg gaagcgttat 780 ggggaagact ctgaacaatt cagagatgct tctaagatcc ttgttgacgc tctgcaaaag 840 tttgcagatg acatgtacag tctttatggt gggaatgcag tggtagagtt agtcactgtc 900 aagtcatttg acacctccct cattaggaag acaaggacta tccttgaggc aaaacaagcg 960 aagaacccag caagtcccta taaccttgca tataagtata attttgaata ttccgtggtt 1020 ttcaacatgg tactttggat aatgatcgcc ttggccttgg ctgtgattat cacctcttac 1080 aatatttgga acatggatcc tggatatgat agcatcattt ataggatgac aaaccagaag 1140

attcgaatgg attgaatgtt acctgtgcca gaattagaaa agggggttgg aaattggctg 1200 ttttgttaaa atatatcttt tagtgtgctt taaagtagat agtatacttt acatttataa 1260 aaaaaaatca aattttgttc tttattttgt gtgtgcctgt gatgtttttc tagagtgaat 1320 tatagtattg acgtgaatcc cactgtggta tagattccat aatatgcttg aatattatga 1380 tatagccatt taataacatt gatttcattc tgtttaatga atttggaaat atgcactgaa 1440 agaaatgtaa aacatttaga atagctcgtg ttatggaaaa aagtgcactg aatttattag 1500 acaaacttac gaatgcttaa cttctttaca cagcataggt gaaaatcata tttgggctat 1560 tgtatactat gaacaatttg taaatgtctt aatttgatgt aaataactct gaaacaagag 1620 aaaaggtttt taacttagag tagccctaaa atatggatgt gcttatataa tcgcttagtt 1680 ttggaactgt atctgagtaa cagaggacag ctgtttttta accctcttct gcaagtttgt 1740 tgacctacat gggctaatat ggatactaaa aatactacat tgatctaaga agaaactagc 1800 cttgtggagt atatagatgc ttttcattat acacacaaaa atccctgagg gacattttga 1860 ggcatgaata taaaacattt ttatttcagt aacttttccc cctgtgtaag ttactatggt 1920 ttgtggtaca acttcattct atagaatatt aagtggaagt gggtgaattc tactttttat 1980 gttggagtgg accaatgtct atcaagagtg acaaataaag ttaatgatga ttccaaaaaa 2040 aaaa 2044 <210> SEQ ID NO 50 <211> LENGTH: 2266 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 50 agcggagcag tagccaccac tccgccgagg ccgcaacccc ggctcggcct ccccaggccc 60 cgccgctgcc gcagtcatgg ctgctgatgg ggtggacgaa cgctcgcctc tgctgtcagc 120 atcccactcc ggaaatgtca ctcccaccgc cccaccgtac ttgcaagaaa gcagccccag 180 agcggagctc ccacctccat atacagccat tgccagtcca gacgccagtg gtattccagt 240 aataaactgc cgtgtgtgcc aatcactaat caatttggat ggcaagcttc accagcatgt 300 ggttaagtgc acagtttgca atgaagctac gccaatcaaa aaccccccaa caggcaagaa 360 atatgttaga tgcccttgta attgtcttct catttgtaag gacacatctc ggcgaatagg 420 atgcccaaga cccaactgta gacggataat taaccttggc ccagtaatgc ttatttctga 480 agaacaacca gctcagcctg cattgccaat ccaaccagaa ggtacaaggg tcgtgtgtgg 540 gcactgtgga aacacattcc tgtggatgga actgaggttc aacactctgg caaaatgccc 600 acactgcaaa aaaatctcct cagtgggtag tgcacttcca cgaagacgct gctgtgcata 660 tattaccatt ggaatgatat gtattttcat tggagttggg ttaactgttg gcaccccaga 720 ttttgcaagg cgatttcgag caacctatgt ttcttgggca attgcttatc tcctaggatt 780 gatctgcctt atccgagctt gttattgggg agccataaga gtcagttatc cagaacacag 840 ttttgcataa gcttgtttat gattcagtaa tgcaggtgag agtgtctagc agttcttggt 900 aagctactct ggacatcttt aaattattta tcctaatgga ttccattctg gtttatgtat 960 aatcgtttca agactttggg agtcttttat gaacaaatgc tcattgcact atattatatg 1020 caaattgttt tgctgctagg ttttcaaaat ttgaataata aagccttttc atgttctttt 1080 acatctctta tagatatttt tggatttgtt accaaacatt acatttactc tcaccctttt 1140 attattttta aataagttat ttcattactt gctgatacat gagtattcct aagtgtttat 1200 aaatatttct ataatagttt cacatttata tttacatttt aattaaacag tatcaaaatt 1260 gcttgcttaa aacctaagca atatgcattt tgcttgaact gcttactgta actttaacct 1320 aagattatag tgaccttatt caggaaaaaa aaaaaattta gtgtaacttc aaagacttga 1380 cattcttgtc agaggaaaaa aaatttctag atactgtttg cttgtttttt gttgtttgta 1440 gaaagataaa atattttggt aataatttaa aatacaagaa cgaatattta tttgtccaca 1500 gttggagatg ttggataaat gtcttttctc aaagatcaca ggacttttgt ctttcatttt 1560 tgccttttta tttaccattt ataaaagatc tggtctggat tatggaattt aatgtttatc 1620 agctctatgt attcctttat agaggcttga ggaagtattt cacataacat gttttataat 1680 acttaaccat ttatccaaag atatatttac attgggttgt gcccctttcc cttagatcat 1740 ggtaaatttt tcttattgag gtaattatgt actacttata tttgaaggaa gcttatgaca 1800 ttttacagta gctaaaatgt tgagattaga ggtactttta ctattcttct caaaggtaac 1860 tgatcagata attacccaaa ttattcaaga aaatagatca gaaataaaga acaacataat 1920 tttctaagaa ttcattgaaa tttatggaat cagctctcgc actgcccatc tttgcagttt 1980 tgaaaaagaa attgcttaat cacaaatgtt ctacagtctt taaatgtagt agaattagac 2040 agtgagatca tctgagtaaa ttgattggtg attccagaga taagactaat attttaaatt 2100 atttatgata ctgattagta taaaaacgta ctcatcacag aatttgaagc aaaatacatg 2160 tacacttcaa agagtaaatg acaaatgtat aaatgctgta gctcaggatt atatgtacct 2220 ttaaaaatac actaataaag attattgttc aaaaaaaaaa aaaaaa 2266 <210> SEQ ID NO 51 <211> LENGTH: 3142 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 51 gtggccgctg ccgcctctgc ctgggtccct tcggccgtac ctctgcgtgg gggctgcctc 60 cccggctccc ggtgcagaca ccatgtacgg atttgtgaat cacgccctgg agttgctggt 120 gatccgcaat tacggccccg aggtgtggga agacatcaaa aaagaggcac agttagatga 180 agaaggacag tttcttgtca gaataatata tgatgactcc aaaacttatg atttggttgc 240 tgctgcaagc aaagtcctca atctcaatgc tggagaaatc ctccaaatgt ttgggaagat 300 gtttttcgtc ttttgccaag aatctggtta tgatacaatc ttgcgtgtcc tgggctctaa 360 tgtcagagaa tttctacaga accttgatgc tctgcacgac caccttgcta ccatctaccc 420 aggaatgcgt gcaccttcct ttaggtgcac tgatgcagaa aagggcaaag gactcatttt 480 gcactactac tcagagagag aaggacttca ggatattgtc attggaatca tcaaaacagt 540 ggcacaacaa atccatggca ctgaaataga catgaaggtt attcagcaaa gaaatgaaga 600 atgtgatcat actcaatttt taattgaaga aaaagagtca aaagaagagg atttttatga 660 agatcttgac agatttgaag aaaatggtac ccaggaatca cgcatcagcc catatacatt 720 ctgcaaagct tttccttttc atataatatt tgaccgggac ctagtggtca ctcagtgtgg 780 caatgctata tacagagttc tcccccagct ccagcctggg aattgcagcc ttctgtctgt 840 cttctcgctg gttcgtcctc atattgatat tagtttccat gggatccttt ctcacatcaa 900 tactgttttt gtattgagaa gcaaggaagg attgttggat gtggagaaat tagaatgtga 960 ggatgaactg actgggactg agatcagctg cttacgtctc aagggtcaaa tgatctactt 1020 acctgaagca gatagcatac tttttctatg ttcaccaagt gtcatgaacc tggacgattt 1080 gacaaggaga gggctgtatc taagtgacat ccctctgcat gatgccacac gcgatcttgt 1140 tcttttggga gaacaattta gagaggaata caaactcacc caagaactgg aaatcctcac 1200 tgacaggcta cagctcacgt taagagccct ggaagatgaa aagaaaaaga cagacacatt 1260 gctgtattct gtccttcctc cgtctgttgc caatgagctg cggcacaagc gtccagtgcc 1320 tgccaaaaga tatgacaatg tgaccatcct ctttagtggc attgtgggct tcaatgcttt 1380 ctgtagcaag catgcatctg gagaaggagc catgaagatc gtcaacctcc tcaacgacct 1440 ctacaccaga tttgacacac tgactgattc ccggaaaaac ccatttgttt ataaggtgga 1500 gactgttggt gacaagtata tgacagtgag tggtttacca gagccatgca ttcaccatgc 1560 acgatccatc tgccacctgg ccttggacat gatggaaatt gctggccagg ttcaagtaga 1620 tggtgaatct gttcagataa caatagggat acacactgga gaggtagtta caggtgtcat 1680 aggacagcgg atgcctcgat actgtctttt tgggaatact gtcaacctca caagccgaac 1740 agaaaccaca ggagaaaagg gaaaaataaa tgtgtctgaa tatacataca gatgtcttat 1800 gtctccagaa aattcagatc cacaattcca cttggagcac agaggcccag tgtccatgaa 1860 gggcaaaaaa gaaccaatgc aagtttggtt tctatccaga aaaaatacag gaacagagga 1920 aacaaagcag gatgatgact gaatcttgga ttgtggggtg aagaggagta cagactaggt 1980 tccagttttc tcctaacacg tgccaagccc aggagcagtt cttccctatg gatacagatt 2040 ttcttttgtc cttgtccatt accccaagac tttcttctag atatatctct cactatccgt 2100 tattcaacct tagctctgct ttctattact ttttaggctt tagtatatta tctaaagttt 2160 ggcttttgat gtggatgatg tgagcttcat gtgtcttaaa atctactaca agcattacct 2220 aacatggtga tctgcaagta gtaggcaccc aataaatatt tgttgaattt agttaaatga 2280 aactgaacag tgtttggcca tgtgtatatt tatatcatgt ttaccaaatc tgtttagtgt 2340 tccacatata tgtatatgta tattttaatg actataatgt aataaagttt atatcatgtt 2400 ggtgtatatc attatagaaa tcattttcta aaggagtgaa ttctaagttt taggggaaaa 2460 aatgcaattt attttcagac tcccaaagta agaattaaca tatcatgcta agaaaatagt 2520 gactattttg aagtatgcta cttccctttc agaaatatag aatacacgtt tctgttatta 2580 aagtatttga ttactaattc aaatcatatg gcaattataa ttcttctaaa atgctatcat 2640 ttgtaactgt atcccctgta ttaaatctca ttaaccacag gcagctgtta cagaaagctg 2700 cattgtttca cattgagctg ttacattagt tcaggctaaa tgttgggcgc tccaaccaca 2760 tccaagaata aatctggaaa cacactgctg ggatactgct gttagagccc ttcttggcct 2820 tgtattccca gaaatgagct ccctttcctt agcttagaag aatgtgatta tatccaggac 2880 atcatgttca gaaaacttag tttactttca gcatagaatg cattactgtt ggaataattg 2940 gcctctagct cttaaatgtc tctgataact tattaatatc tatctttata aaatagagtg 3000 caactacttt tgtgtaaaaa tgtttgcctt taaatttagt atttcatatc agcacatcga 3060 tatatgtata aatgttccat gttaatgtgt aaaagagtct gtaataaatt atttttttca 3120 cgtgtcaaaa aaaaaaaaaa aa 3142 <210> SEQ ID NO 52 <211> LENGTH: 5537 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 ggaactgccg cggccgccac cgccgctgcc ggcgccgctg ctgtagggga ccagcgcggg 60 tgcgcagacg aaaggcgctc tttgccagct gaaagttccc acggaaaaac taccatctcc 120 cctgcccacc atggcagacg aaattgattt cactactgga gatgccgggg cttccagcac 180 ttaccctatg cagtgctcgg ccttgcgcaa aaacggcttc gtggtgctca aaggacgacc 240 atgcaaaata gtggagatgt caacttccaa aactggaaag catggtcatg ccaaggttca 300 ccttgttgga attgatattt tcacgggcaa aaaatatgaa gatatttgtc cttctactca 360 caacatggat gttccaaata ttaagagaaa tgattatcaa ctgatatgca ttcaagatgg 420

ttacctttcc ctgctgacag aaactggtga agttcgtgag gatcttaaac tgccagaagg 480 tgaactaggc aaagaaatag agggaaaata caatgcaggt gaagatgtac aggtgtctgt 540 catgtgtgca atgagtgaag aatatgctgt agccataaaa ccctgcaaat aaacggaaac 600 atcaggcatg aacactgttt atgtctgaat caactgcaga tctaatttgg ttctaagttg 660 tcaccaaagc tatagccttc ataagcaacc tcatttcttt ttttaattgt tttcagattg 720 tgctgggtta gttttgcaag caattgataa tttttaaaaa attatcaata tgtataattt 780 tttttgaatt ttgtagatat gtttcctata atattcctgt ggttttcagt atgtcagtcc 840 aagaaacaaa caagatagct tcagcagatg tgatttgtct gagcaaatca ttcctgtgtt 900 ttagttagat gataaaccag ggttttaaat caaacaatgt agcataaagt ggtattgaag 960 taccatattt aagttgaact gctctgcatt aattacagat ttaatataaa atgaactgat 1020 tatatattgg aattgttgca ctttcagcct gtgtagggca aacacaaatc cttaaacaaa 1080 aatcatgtta tcaaaaactg tcagttattt tggtggccac atgcaaccat gtgattactt 1140 tggtcatact atttaccaaa ttgttggcaa acttgatgta accttatatg gtggttttag 1200 tcccttctta tggttggcag aagggcactg aactgttggg tgaaagttag ttagcaagta 1260 agattataag gaagacacaa aagacagtgg caaagagggt tgattaaatc tataagtttt 1320 tatgtgagga ctttgtaagt cagcataaaa atgaaaagtt gtttctcagt tgtttttgct 1380 tttaactttg cccccaacgt ttaaagggag tgatctgctt tacatgatac tatgcaatgc 1440 ttgttttcca actatgttga ataaatagta atatttatca gtaaatactc ctttccaact 1500 tccttttttt tttttttttt tttgagactg agtctcactc catcagccag gctggagtgc 1560 agtggtgcaa tctcggctca ctgcaacctc tgcctcccga gttcaagcaa ttctcctgcc 1620 tcagcctccc aagtagctgg gactacaggt gcatgccacc acgcccagct acttttttgt 1680 gtattttagt agagatgggg tttcaccatg ttgtctaggc tggtcttgaa ctcctgacct 1740 caggtgatcc acctgcctca gcctcccaaa gtgctgggat tacaggcatg agccaccaca 1800 cccagcccct ttccaaccat ttctaagtag attttttgac attaatgtat ttattaaaca 1860 aaaactgaga attccttaaa ttgatttgga atttttgtta attttatgtc ctttttttcc 1920 taaagtgaat taaagtgaat catggaagca gcattacttt atatgaatat tattatttaa 1980 gttaagttat tttaagtata tgcatttttt ctgattgttg tgtgacttaa ttcagttgct 2040 ggtgtgaact ataactagca aataattcta taaactgaat tattttaaaa ggtattttag 2100 gtgacaccac tgcatttcta tttcatcttt tgagtcatat gtatattatt tccagaattt 2160 tagacattat tacagggttt gtgaggacct ttgactcagt gacaatcatc atattggagc 2220 aaaacataga acaaaatcac tatctcagaa ataccttaat tctctaagac tggctcttag 2280 acctctccca tcatgccttg acctctaaaa agccctttgt tcctatcttc taaaggaaag 2340 tatatcatat atgatgatgt aactgatcta atcagtgact ggaaatagca ttagtaacag 2400 aagatcccaa gttttagttg cttaatttgt acacactttt aaatattgtc ttagcctcgg 2460 caaaccaatt tggggaagaa gcaagatact ttaagagaaa tacaaaggaa atttctaaag 2520 cacaagaaat agtgaggtag tagttagtcg tctttcctac aacattttag cttttgccca 2580 tctaaagcac aattaaaatt aggctacatt ctttccagta ttctatttaa gtacctacta 2640 catactgctc tagtttctta gtactctgta atgtgtatct taattgctac tggttggcat 2700 tgtaactcat aggaattcca gaaaattatt aatccgtgct gcttgcagtt cattcatatg 2760 gcccctctta accatgctgg tgttatgatt cagtattaac tctcaattag catgcccctg 2820 ttcttcctaa cttgtaaaat ttcacataaa tatattttca attgtgtaca aattaagggt 2880 gtacaaatta taataatgca tctctatctt catactttga atggcaaacg ctatttatgc 2940 ataaatattt tcattttaag taatatatga agtgtaaata ctcgatatat aagtatagat 3000 tttaaagata tgggacttta ttttcacata agtcaataga tgtttctcta gaacaaaata 3060 tttagtaaag ctttataaat tatattaaaa ggaagcgggg aacatgtatt ttttaacata 3120 gaacagaagt gacttcattc tttttagaca tcagaaatgt taaagttgat tcccaatatt 3180 tgttgtactt ttttgtagca aatgttaaaa atcacgagtt accatgtata gaatgtggac 3240 tgtcatgttg atatcattgt acagtgataa gccattttta tctgtataca tttcaccaat 3300 ttattaacag gttgaatatt tgtttctttt tagaacattt tatttatact gtgaagactt 3360 tgttatacct tatttgctac aacatagatc atatcattgc tactttgact tagcatttgc 3420 atcataaaca taattatgat gtttttttca tgctcccttc caggggctca gtcacttgaa 3480 gaaactgttg ctaaccaagc tcttgactct gtttccctta atgatacaag tctctgtacc 3540 agcgctttat gttaattacc aaaactctcc tgcatcagag catgatatct ataataggag 3600 atactgcaat aaaatgatta ggctgtaaaa tttggagaca caatttttca ttacaatgca 3660 atttgcatgt gcacatgtgc gcacataact ttatatgtta gttctttttt ccaaactccc 3720 aactcttaaa agtattgtag tctgttggtg cctcaactgt tggtaacttt ttttttttaa 3780 atttacaact ttccacaact tgtttttgta ctttaaggtt tctcaattag aatatttcta 3840 gttgagctgt aatttgaatg cattgttctc agggctattt gtgctaaaag ctgaaatttc 3900 attattttaa agctaattgc ctgaaaatat attggcagaa ttttcccaaa ttgtaataac 3960 tgtgatacat gcatataaaa aaatccttaa tgtcaacaca cttaaactac atgctaaata 4020 gtcaagaaaa aaatggaaac agtagcatcc atactggaat cttgccatat ttttttcatt 4080 ttagaataga ttttggcagt ctcatcttag aatcctatcc ttaggataca tctgaaagca 4140 ttcctttggc atggacccca gagatagttt tggagccagg cattgatgta gaggttcacc 4200 aaacatattt agggataata gataaattca taatgctttt ttgggtacac tgaaatgttt 4260 acatactgaa ttctgtaata tgaactagga acgcatttac tatgagaaaa tatggctctt 4320 aagcagtgta agagtgaaaa tataagcata tttccattaa cagtatattg tactgatcag 4380 cagctctcat tttaacatca gttaggcata atatttcata gttttcaagc cttttttttc 4440 tgctaacatt cagacaagta acaggcaaca aagatttaag aaaaatttat ggtggaaaac 4500 cttaaaaatt gagacaattc aatctattta atctattaaa ttttttctct gaattgggta 4560 tatggcatca ttatttgatt ttagcaggga acatttggat ttagcttatg aaacacagat 4620 gttctatggg aacatggctt gaagccaata tgtaatttaa tgtttttcca ttaaacaaac 4680 atctgaacac caacttagct accaagtgag gtcaagtgcc tgaaaagtac tgtatacatc 4740 taataagcat gttttcctta tgtaaaagat gcactttatg gcaatgcata ccaggctttc 4800 acctgctaga aacatacttg ttgccaactt tgccatctac cactattctc ctccttagaa 4860 caggtagaaa cctattttac aaaaaaaaaa aaaaaaaaaa aaagacaggt tattgtattt 4920 atatgaagtc cctaaaactg tttcttggta ttgatagact taagtttatc ttagttcaag 4980 attgcacttt ttaaaaaact ctggactatt ttcagcaatg accgaacagc ttgtcacaca 5040 tcatagttgt gatctttttt gaggagttat ttattgtggt taatatctac tataaataag 5100 cattcttgtg cttgttacaa agcataatgc aaattactag ttctatacta gtataatgaa 5160 aatgactagt tctatactgt tatgtacttt tgtcttcctc cccaaaaagg aaacagttta 5220 gcattgtcta aattcagtgg cactttttta gtaatacatt tttttttctt agatacagga 5280 gaactattgc ttttacctgc agaaactcaa atgttttcgc taaaacttta aaattctaaa 5340 atacgtagta tgggtattac taattgtaca ttttacattt caaaaatagt taaaattcaa 5400 atgttaagtc tttgacttaa aaaaccttta aatatagata ataccttaac aattataact 5460 ttgtgatatt attaaaatat atttgtctgt taacttcatc agttgtatta aataaaaata 5520 gttaacagct tgcacta 5537 <210> SEQ ID NO 53 <211> LENGTH: 1444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 53 tttcattttg ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac 60 cccgggagtt aatccgaaag cgccgcaagc cccgcgggcc ggccgcaccg cacgtgtcac 120 cgagaagctg atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg 180 ggaaagtcct gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc 240 agccaccgcc ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc 300 tgcagtgccg gctcagcatg tgtccagcgc gcagcctcct ccttgtggct accctggtcc 360 tcctggacca cctcagtttg gccagaaacc tccccgtggc cactccagac ccaggaatgt 420 tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg ctccagaagg 480 ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca 540 caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga 600 gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa 660 agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc 720 aggtggagtt caagaccatg aatgcaaagc ttctgatgga tcctaagagg cagatctttc 780 tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg 840 agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc 900 tctgcatact tcttcatgct ttcagaattc gggcagtgac tattgataga gtgatgagct 960 atctgaatgc ttcctaaaaa gcgaggtccc tccaaaccgt tgtcattttt ataaaacttt 1020 gaaatgagga aactttgata ggatgtggat taagaactag ggagggggaa agaaggatgg 1080 gactattaca tccacatgat acctctgatc aagtattttt gacatttact gtggataaat 1140 tgtttttaag ttttcatgaa tgaattgcta agaagggaaa atatccatcc tgaaggtgtt 1200 tttcattcac tttaatagaa gggcaaatat ttataagcta tttctgtacc aaagtgtttg 1260 tggaaacaaa catgtaagca taacttattt taaaatattt atttatataa cttggtaatc 1320 atgaaagcat ctgagctaac ttatatttat ttatgttata tttattaaat tatttatcaa 1380 gtgtatttga aaaatatttt taagtgttct aaaaataaaa gtattgaatt aaagtgaaaa 1440 aaaa 1444 <210> SEQ ID NO 54 <211> LENGTH: 3189 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 54 agcgggcggg actgccgggt gatgagatac tcggtcggcg acggtagaac gggcgacggc 60 gacaaccgca atcacatcca cgacggtgat catggcagag aatcacgccc agaataaagc 120 caagctcatc tctgagaccc ggaggaggtt cgaagctgag tatgtgacag ataagtcaga 180 taaatatgat gcacgtgatg ttgaaaggct acaacaagat gataactggg ttgaaagtta 240 cttatcttgg agacataata ttgtagatga aacactgaag atgctcgatg agagttttca 300 gtggaggaaa gaaatttctg tcaatgacct taatgaatcc tccattccca gatggttatt 360

ggaaattggt gttatttatc tccatggtta tgacaaagaa ggtaacaaat tgttctggat 420 cagggtgaag tatcatgtaa aagaccagaa aaccatattg gacaaaaaga agctcatagc 480 attctggttg gaacgttatg ctaagaggga aaatgggaaa cctgtaacag tgatgtttga 540 cctgtcagaa actggaataa atagcattga catggacttt gtacgcttta tcatcaactg 600 ctttaaggtt tattacccta aatacctctc aaaaatagtg atctttgata tgccttggtt 660 aatgaatgct gctttcaaaa ttgtgaaaac ctggcttggt ccagaagcag tgagcttgtt 720 gaagtttaca agcaaaaatg aagtccagga ctatgtcagt gtagaatacc tgcctcccca 780 catgggtgga actgatcctt tcaagtatag ctatccacca ctagtagatg atgacttcca 840 gaccccactg tgtgagaatg ggcctattac cagtgaggat gaaacttcaa gtaaagaaga 900 catagaaagt gatggcaaag aaacattgga aacaatttct aatgaagaac aaacacctct 960 tcttaaaaag attaacccaa ccgaatctac ttccaaagca gaagaaaatg aaaaagttga 1020 ttcaaaagtg aaagctttca agaaaccatt gagtgtattt aaaggcccct tactacacat 1080 cagcccagca gaagaactgt actttggaag tacagaatcc ggagagaaga aaaccttaat 1140 agtgttgaca aatgtaacta aaaatatagt ggcatttaag gtgagaacaa cagctccaga 1200 aaaatacaga gtcaagccaa gcaatagcag ctgtgacccg ggtgcatcag tggatatagt 1260 tgtgtctccc catgggggtt taacagtctc tgcccaagac cgttttctga taatggctgc 1320 agaaatggaa cagtcatctg gcacaggccc agcagaatta actcagtttt ggaaagaagt 1380 tcccagaaac aaagtgatgg aacataggtt aagatgccat actgttgaaa gcagtaaacc 1440 aaacactctt acgttaaaag acaatgcttt caatatgtca gataaaacca gtgaagatat 1500 atgtctacaa ctcagtcgtt tactagaaag caataggaag cttgaagacc aagttcagcg 1560 ttgtatctgg ttccagcagc tgctgctttc cttaacaatg ctcttgcttg cttttgtcac 1620 ctctttcttc tatttattgt acagttaaag aagtggtgcc gggtaggaac cacggttcct 1680 tcgtccatta gttggaaaaa gtaacagacc taaaactcta ccaagctact aaaaacattg 1740 cacatctgtg cttcctaaaa ggaaatatgc agcacgtgga ggggaacaca tacatgtctt 1800 gaaaataaac tgctagaata aagaaatgct ggagaaattg attataagag actatagcta 1860 tttagtaaag taagtaaagg catatccatt gtgtaaatta atagtttaaa tataatttat 1920 tttttccttt tgatctgaat acttttaaag cttaagtttt atcgtgtaaa tacattagct 1980 aaactgaaaa gtataagtaa catgctttgt tgcagccaaa aaatgtaatc tgctttttta 2040 tgacagaatt attatagctg agctgactta ctagcttttc tatactatgt atatagaaga 2100 acatgtatat tgagaaagaa aacatactta tatagaggaa tttatgtaac catgactttg 2160 taattttgag aattcctccc agtgatggtc agtattcttt tggaatgtaa accgatttaa 2220 tgccaaacca ccttaacctt tgtttctcag tgttccttaa cagcctgcct tttattaatc 2280 tcaggttttt ttatgaacac tctcatttca gtagaatttg gaaaactaag cgtggttgga 2340 atttctttga attctgttag taatgcccaa aagaaaagtc tcaagcagtc cccctatcca 2400 gtcattttta tggagtttca tgttgtccac tatagctgga cactgaacct tttgcctaat 2460 ttattataaa ggcctgaccc tctattgtcc catcttcacc cccattccag agcagaggag 2520 tctctgtgga ccatgaattg cactgtctcc ctcctcattt ctaaatgaaa ggtattagat 2580 ataaattttt ttgaaaggtt agttgtttga gatgctaagc aggataataa atttagattt 2640 taaaatgttc cctgtaaaag tcagcccatg acaaggaaat ttacaaaata ctagagtatc 2700 tagaagggtg aaaacaaaaa aaaataaaaa gaaacacaga cgcccaggtg tcagctctcc 2760 gtttaaagaa tgaaaaatgt aactcatgat gatctgtgaa accttcaaac taggaccaat 2820 tgacttactt gatattctgc ctttgatatg gtagtaccca cccggtattc ctaaaatcct 2880 aaaaagatac accttgcagt agcagaggca atgacatgag tttgttttct cattaatatg 2940 accagtttgg gtctatgttg gttcacatgt acatctactt tatatgaaag aaaaaacagt 3000 tgtctgcctg taaaatgttg agtttcgatt gagccatgtt tggagatttt attactattc 3060 tgaagggtag tgttgttggt tttcatcttc aagaagttga ttccaaaact gagttatgaa 3120 gaatgatata acagttcctt caaaattggc ctaggaaata aaaccttaaa aggaaaaaaa 3180 aaaaaaaaa 3189 <210> SEQ ID NO 55 <211> LENGTH: 2266 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 55 agcggagcag tagccaccac tccgccgagg ccgcaacccc ggctcggcct ccccaggccc 60 cgccgctgcc gcagtcatgg ctgctgatgg ggtggacgaa cgctcgcctc tgctgtcagc 120 atcccactcc ggaaatgtca ctcccaccgc cccaccgtac ttgcaagaaa gcagccccag 180 agcggagctc ccacctccat atacagccat tgccagtcca gacgccagtg gtattccagt 240 aataaactgc cgtgtgtgcc aatcactaat caatttggat ggcaagcttc accagcatgt 300 ggttaagtgc acagtttgca atgaagctac gccaatcaaa aaccccccaa caggcaagaa 360 atatgttaga tgcccttgta attgtcttct catttgtaag gacacatctc ggcgaatagg 420 atgcccaaga cccaactgta gacggataat taaccttggc ccagtaatgc ttatttctga 480 agaacaacca gctcagcctg cattgccaat ccaaccagaa ggtacaaggg tcgtgtgtgg 540 gcactgtgga aacacattcc tgtggatgga actgaggttc aacactctgg caaaatgccc 600 acactgcaaa aaaatctcct cagtgggtag tgcacttcca cgaagacgct gctgtgcata 660 tattaccatt ggaatgatat gtattttcat tggagttggg ttaactgttg gcaccccaga 720 ttttgcaagg cgatttcgag caacctatgt ttcttgggca attgcttatc tcctaggatt 780 gatctgcctt atccgagctt gttattgggg agccataaga gtcagttatc cagaacacag 840 ttttgcataa gcttgtttat gattcagtaa tgcaggtgag agtgtctagc agttcttggt 900 aagctactct ggacatcttt aaattattta tcctaatgga ttccattctg gtttatgtat 960 aatcgtttca agactttggg agtcttttat gaacaaatgc tcattgcact atattatatg 1020 caaattgttt tgctgctagg ttttcaaaat ttgaataata aagccttttc atgttctttt 1080 acatctctta tagatatttt tggatttgtt accaaacatt acatttactc tcaccctttt 1140 attattttta aataagttat ttcattactt gctgatacat gagtattcct aagtgtttat 1200 aaatatttct ataatagttt cacatttata tttacatttt aattaaacag tatcaaaatt 1260 gcttgcttaa aacctaagca atatgcattt tgcttgaact gcttactgta actttaacct 1320 aagattatag tgaccttatt caggaaaaaa aaaaaattta gtgtaacttc aaagacttga 1380 cattcttgtc agaggaaaaa aaatttctag atactgtttg cttgtttttt gttgtttgta 1440 gaaagataaa atattttggt aataatttaa aatacaagaa cgaatattta tttgtccaca 1500 gttggagatg ttggataaat gtcttttctc aaagatcaca ggacttttgt ctttcatttt 1560 tgccttttta tttaccattt ataaaagatc tggtctggat tatggaattt aatgtttatc 1620 agctctatgt attcctttat agaggcttga ggaagtattt cacataacat gttttataat 1680 acttaaccat ttatccaaag atatatttac attgggttgt gcccctttcc cttagatcat 1740 ggtaaatttt tcttattgag gtaattatgt actacttata tttgaaggaa gcttatgaca 1800 ttttacagta gctaaaatgt tgagattaga ggtactttta ctattcttct caaaggtaac 1860 tgatcagata attacccaaa ttattcaaga aaatagatca gaaataaaga acaacataat 1920 tttctaagaa ttcattgaaa tttatggaat cagctctcgc actgcccatc tttgcagttt 1980 tgaaaaagaa attgcttaat cacaaatgtt ctacagtctt taaatgtagt agaattagac 2040 agtgagatca tctgagtaaa ttgattggtg attccagaga taagactaat attttaaatt 2100 atttatgata ctgattagta taaaaacgta ctcatcacag aatttgaagc aaaatacatg 2160 tacacttcaa agagtaaatg acaaatgtat aaatgctgta gctcaggatt atatgtacct 2220 ttaaaaatac actaataaag attattgttc aaaaaaaaaa aaaaaa 2266 <210> SEQ ID NO 56 <211> LENGTH: 3234 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 56 gtttgcattt ctaatgacag tgaactgaca aagcgtgaaa gtggtctaag gagcaaaaca 60 aagccagcaa gcctgcttct ggtgtgccaa gattaatcaa tattccagaa acctcgggtt 120 tcccctcctc cctgtgcggt ttccattccc cactcctcct ttcccgggca cagactcctc 180 cctctcttct taagttgccc tgatagtaac ttgcagtttc agagcacatg cacactgtca 240 ggctagcctg cctgcttacg cgcgctgcgg attgttgctc cgttgtacct gctgggaatt 300 cacctcgtta ctgcttgata tcttccaccc cttacaaaat cagaaaaggt aagtgtcaca 360 ttctgtgttc ctgctgggtt taatttctcc tttcacttct ctgccgatgt atttgccttc 420 caagcagagg agtagcctga atcaaggcta gccattttgg tagataaagt ccttgttagt 480 catctcacgt cgtgagagtg tggtgctgtt tatgccggtc gctgttaatt cggagttgag 540 tcattcgggg tggattgggg gcagattgtg gcgcgagatc tagaaaaagg atcaaggttg 600 agcggatctg cttaaaagtg actggtaaga ggaatcagag ctattagttt aaaaaaaaaa 660 aaattccttg ggtccttcct tcccttattt cccggtcttc cacttctccc taagcattta 720 atccagtgtg aagtcttaaa caaattagaa gtcttagtat cactgacccc aacttgcaat 780 tttatttaaa aggcaaactg ttaagacaag tctttttttt tcctgcactg ggattgcgag 840 aagtcatttg cgaggagtcc tttggtttcc agttacctcc ccacaggcgc acacgctggc 900 tgcttgcgtt ggcagcgaca cacatccatg gtacggctgg ttttcactcg gattgattat 960 gggaagggct atggattaga gctcctgtaa agcaccaagg aggaatccct tgatttttca 1020 gaacagctga tttccaccag gaaagagatt tactgaaatg tagttaaata gcgtgagtgc 1080 tttaaagaaa ccagaaacca caagctgtaa tgtttggaat gaaaattggt ttcatctcat 1140 ctgttctaga aatcctaaat tttaaaacgc taaaaagtca gcgatagttt ctcggaagat 1200 tccagcatgt gtgtcacaaa gaaaaacact acttcatact tctacttgtg ataaacgaag 1260 ctgaattgtg atttcagatg atttatagat gtgcccagag cactttgctt atttcatgga 1320 aaaaaaatga aaaaattacc ctgtaaaata gtcacatgta tttcccatgt actgtgggca 1380 cttgtgttct ttttatgacc atatttacta gtagatatta ttatattttt tcttaatgaa 1440 gaaaatagct ggttacttta ctgcatgtaa cagagacaac tcccacctat cagtatctta 1500 attattttta ttgacctggt tatgctttca accatgtata cagcataatt tgtcaagtaa 1560 tgattgaata ctttctgtgc attcagttca attggacatt tactgattgt gtacgttgtg 1620 caaggcatca gctgggttct gcgggggagg gtgggaatag gggttctcag tcagatctag 1680 ctctgaagaa cccttttata gcctcattgg aaggggaagg acggattttt aaaaagaaaa 1740 tagaatatat tccgaattta tgcacatttc tcacacgtgg tccactaaaa tatgcacact 1800 gcaaccttga ggtctggtat tgtggctctc cagtccttga ttcctgctga gattatgcaa 1860 tttgccaaga gcttgcctgg tgtggagcag cactgatttc tcacccctgg aggctataac 1920

tcatgtctct ttttctccca ttctagttgt gttttctaat accaaagagg aggtttggct 1980 ttctgtgggt gattcccaga cactgaagtg caaagaagag accctcctag aaaagtaaaa 2040 tatgactaaa agcaatggag aagagcccaa gatggggggc aggatggaga gattccagca 2100 gggagtccgt aaacgcacac ttttggccaa gaagaaagtg cagaacatta caaaggagga 2160 tgttaaaagt tacctgtttc ggaatgcttt tgtgctgctc acagtcaccg ctgtcattgt 2220 gggtgagtca tttgattaaa aacaaaaaaa cctgtatctt gtttctctgg ggcatctggc 2280 tgcccgggga atattatcag atgaactagt tgtaggtatc aaaatggtag cctaggcttt 2340 cctctgaact tgatgatttt tctccataaa aatgactgtt ttggcttgtt tggagcaata 2400 tatagtaaac acatcattag gcatcattag gcatcattag gcattatgca aatcaattgt 2460 gtgaggaaga aaataaataa aatattttcc catttcatgt aaggataagg aagtgatcat 2520 ttaatcatta ggcatgacaa agcaagcatg ctagatttgg ccaaaatgta attatataca 2580 atgtcagttg cacttaaaac taatttatac aattagtaca cctaaaatga catgttggtt 2640 ccaaatagta attatattct aactggtgct gacttgaagc tgagtatcaa cgcttaggca 2700 cagagaccga atattttatg tgtttgcact ctctcaccca gcaactggga aaggtagatt 2760 ggggaaaatg ttaacacaga tctctttcat tcattgcttt gcagagcctg ccataaccag 2820 ctataccttt ttttgaatca tttccatctc ttactaattt agcagggttg acagcaatct 2880 gtactaataa aatattattg ttttgttttg tttattgatc ttaaaagtta tagtttatta 2940 cttatgggtg gcattgatcc tactttaaaa tatagctgaa aaaacctact tatttggaat 3000 tttgaccaac caatacagaa tccttagatt gacaacatat acgccaatgc caggttgtaa 3060 atattccaac ttaacctacc aatttgccac caaaaaagag gcattcagta ccgttttaat 3120 ctctactttg gagtttgcca agatttccat caactttaaa gaggtaatga tttaataaag 3180 attaagaaaa ttctgtagtg tgtaaatata acttttttca agaaaattga attc 3234 <210> SEQ ID NO 57 <211> LENGTH: 3331 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 57 cagagggcac cgcccaggcc tcggaaggtg tcagggagaa ctttccgtgg tttcagcgtc 60 gtcgcctgga gcggcggttt agagagccga gcctgatggg cgccaaggcc ggctggctgc 120 ttggagcgct gcctcgaagg gactgcgtaa ggaagctaat ccggagaacc caggccagag 180 cctgaaatat ggcgacctgc atcggggaga agatcgagga ttttaaagtt ggaaatctgc 240 ttggtaaagg atcatttgct ggtgtctaca gagctgagtc cattcacagt ggtttggaag 300 ttgcaatcaa aatgatagat aagaaagcca tgtacaaagc aggaatggta cagagagtcc 360 aaaatgaggt gaaaatacat tgccaattga aacatccttc tatcttggag ctttataact 420 attttgaaga tagcaattat gtgtatctgg tattagaaat gtgccataat ggagaaatga 480 acaggtatct aaagaataga gtgaaaccct tctcagaaaa tgaagctcga cacttcatgc 540 accagatcat cacagggatg ttgtatcttc attctcatgg tatactacac cgggacctca 600 cactttctaa cctcctactg actcgtaata tgaacatcaa gattgctgat tttgggctgg 660 caactcaact gaaaatgcca catgaaaagc actatacatt atgtggaact cctaactaca 720 tttcaccaga aattgccact cgaagtgcac atggccttga atctgatgtt tggtccctgg 780 gctgtatgtt ttatacatta cttatcggga gaccaccctt cgacactgac acagtcaaga 840 acacattaaa taaagtagta ttggcagatt atgaaatgcc aacttttttg tcaatagagg 900 ccaaggacct tattcaccag ttacttcgta gaaatccagc agatcgttta agtctgtctt 960 cagtattgga ccatcctttt atgtcccgaa attcttcaac aaaaagtaaa gatttaggaa 1020 ctgtggaaga ctcaattgat agtgggcatg ccacaatttc tactgcaatt acagcttctt 1080 ccagtaccag tataagtggt agtttatttg acaaaagaag acttttgatt ggtcagccac 1140 tcccaaataa aatgactgta tttccaaaga ataaaagttc aactgatttt tcttcttcag 1200 gagatggaaa cagtttttat actcagtggg gaaatcaaga aaccagtaat agtggaaggg 1260 gaagagtaat tcaagatgca gaagaaaggc cacattctcg ataccttcgt agagcttatt 1320 cctctgatag atctggcact tctaatagac agtctcaagc aaaaacatat acaatggaac 1380 gatgtcactc agcagaaatg ctttcagtgt ccaaaagatc aggaggaggt gaaaatgaag 1440 agaggtactc acccacagac aacaatgcca acatttttaa cttctttaaa gaaaagacat 1500 ccagtagttc tggatctttt gaaagacctg ataacaatca agcactctcc aatcatcttt 1560 gtccaggaaa aactcctttt ccatttgcag acccgacacc tcagactgaa accgtacaac 1620 agtggtttgg gaatctgcaa ataaatgctc atttaagaaa aactactgaa tatgacagca 1680 tcagcccaaa ccgggacttc cagggccatc cagatttgca gaaggacaca tcaaaaaatg 1740 cctggactga tacaaaagtc aaaaagaact ctgatgcttc tgataatgca cattctgtaa 1800 aacagcaaaa taccatgaaa tatatgactg cacttcacag taaacctgag ataatccaac 1860 aagaatgtgt ttttggctca gatcctcttt ctgaacagag caagactagg ggtatggagc 1920 caccatgggg ttatcagaat cgtacattaa gaagcattac atctccgttg gttgctcaca 1980 ggttaaaacc aatcagacag aaaaccaaaa aggctgtggt gagcatactt gattcagagg 2040 aggtgtgtgt ggagcttgta aaggagtatg catctcaaga atatgtgaaa gaagttcttc 2100 agatatctag tgatggaaat acgatcacta tttattatcc aaatggtggt agaggttttc 2160 ctcttgctga tagaccaccc tcacctactg acaacatcag taggtacagc tttgacaatt 2220 taccagaaaa atactggcga aaatatcaat atgcttccag gtttgtacag cttctaagat 2280 ctaaatctcc caaaatcact tattttacaa gatatgctaa atgcattttg atggagaatt 2340 ctcctggtgc tgattttgag gtttggtttt atgatggggt aaaaatacac aaaacagaag 2400 atttcattca ggtgattgaa aagacaggga agtcttacac tttaaaaagt gaaagtgaag 2460 ttaatagctt gaaagaggag ataaaaatgt atatggacca tgctaatgag ggtcatcgta 2520 tttgtttagc actggaatcc ataatttcag aagaggaaag gaaaactagg agtgctccct 2580 ttttcccaat aatcatagga agaaaacctg gtagtactag ttcacctaag gccttatcac 2640 ctcctccttc tgtggattca aattacccaa cgagagatag agcatctttc aacagaatgg 2700 tcatgcatag tgatgcttct ccaacacagg caccaatcct taatccctct atggttacaa 2760 atgaaggact tggtcttaca actacagctt ctggaacaga catctcttct aatagtctaa 2820 aagattgtct tcctaaatca gcacaacttt tgaaatctgt ttttgtgaaa aatgttggtt 2880 gggctacaca gttaactagt ggagctgtgt gggttcagtt taatgatggg tcccagttgg 2940 ttgtgcaggc aggagtgtct tctatcagtt atacctcacc aaatggtcaa acaactaggt 3000 atggagaaaa tgaaaaatta ccagactaca tcaaacagaa attacagtgt ctgtcttcca 3060 tccttttgat gttttctaat ccgactccta attttcattg attaaaactc ctttcagaca 3120 tataagttta ataaataact tttttgttga ctttcaagta aagtgatttt ttttaattta 3180 acataaagtc ttcagaaagc ctttctatga aagaatttta acctataatg taaaccatgt 3240 atctgagata acaaagcaga atgaaacttg agtcacttac taaatatagt ggatataaaa 3300 tagaacacct gactttgctc ttagaccata a 3331 <210> SEQ ID NO 58 <211> LENGTH: 3007 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 58 gcccggagag ccgcatctat tggcagcttt gttattgatc agaaactgct cgccgccgac 60 ttggcttcca gtctggctgc gggcaaccct tgagttttcg cctctgtcct gtcccccgaa 120 ctgacaggtg ctcccagcaa cttgctgggg acttctcgcc gctcccccgc gtccccaccc 180 cctcattcct ccctcgcctt cacccccacc cccaccactt cgccacagct caggatttgt 240 ttaaaccttg ggaaactggt tcaggtccag gttttgcttt gatccttttc aaaaactgga 300 gacacagaag agggctctag gaaaaagttt tggatgggat tatgtggaaa ctaccctgcg 360 attctctgct gccagagcag gctcggcgct tccaccccag tgcagccttc ccctggcggt 420 ggtgaaagag actcgggagt cgctgcttcc aaagtgcccg ccgtgagtga gctctcaccc 480 cagtcagcca aatgagcctc ttcgggcttc tcctgctgac atctgccctg gccggccaga 540 gacaggggac tcaggcggaa tccaacctga gtagtaaatt ccagttttcc agcaacaagg 600 aacagaacgg agtacaagat cctcagcatg agagaattat tactgtgtct actaatggaa 660 gtattcacag cccaaggttt cctcatactt atccaagaaa tacggtcttg gtatggagat 720 tagtagcagt agaggaaaat gtatggatac aacttacgtt tgatgaaaga tttgggcttg 780 aagacccaga agatgacata tgcaagtatg attttgtaga agttgaggaa cccagtgatg 840 gaactatatt agggcgctgg tgtggttctg gtactgtacc aggaaaacag atttctaaag 900 gaaatcaaat taggataaga tttgtatctg atgaatattt tccttctgaa ccagggttct 960 gcatccacta caacattgtc atgccacaat tcacagaagc tgtgagtcct tcagtgctac 1020 ccccttcagc tttgccactg gacctgctta ataatgctat aactgccttt agtaccttgg 1080 aagaccttat tcgatatctt gaaccagaga gatggcagtt ggacttagaa gatctatata 1140 ggccaacttg gcaacttctt ggcaaggctt ttgtttttgg aagaaaatcc agagtggtgg 1200 atctgaacct tctaacagag gaggtaagat tatacagctg cacacctcgt aacttctcag 1260 tgtccataag ggaagaacta aagagaaccg ataccatttt ctggccaggt tgtctcctgg 1320 ttaaacgctg tggtgggaac tgtgcctgtt gtctccacaa ttgcaatgaa tgtcaatgtg 1380 tcccaagcaa agttactaaa aaataccacg aggtccttca gttgagacca aagaccggtg 1440 tcaggggatt gcacaaatca ctcaccgacg tggccctgga gcaccatgag gagtgtgact 1500 gtgtgtgcag agggagcaca ggaggatagc cgcatcacca ccagcagctc ttgcccagag 1560 ctgtgcagtg cagtggctga ttctattaga gaacgtatgc gttatctcca tccttaatct 1620 cagttgtttg cttcaaggac ctttcatctt caggatttac agtgcattct gaaagaggag 1680 acatcaaaca gaattaggag ttgtgcaaca gctcttttga gaggaggcct aaaggacagg 1740 agaaaaggtc ttcaatcgtg gaaagaaaat taaatgttgt attaaataga tcaccagcta 1800 gtttcagagt taccatgtac gtattccact agctgggttc tgtatttcag ttctttcgat 1860 acggcttagg gtaatgtcag tacaggaaaa aaactgtgca agtgagcacc tgattccgtt 1920 gccttgctta actctaaagc tccatgtcct gggcctaaaa tcgtataaaa tctggatttt 1980 tttttttttt tttgctcata ttcacatatg taaaccagaa cattctatgt actacaaacc 2040 tggtttttaa aaaggaacta tgttgctatg aattaaactt gtgtcgtgct gataggacag 2100 actggatttt tcatatttct tattaaaatt tctgccattt agaagaagag aactacattc 2160 atggtttgga agagataaac ctgaaaagaa gagtggcctt atcttcactt tatcgataag 2220 tcagtttatt tgtttcattg tgtacatttt tatattctcc ttttgacatt ataactgttg 2280 gcttttctaa tcttgttaaa tatatctatt tttaccaaag gtatttaata ttctttttta 2340

tgacaactta gatcaactat ttttagcttg gtaaattttt ctaaacacaa ttgttatagc 2400 cagaggaaca aagatgatat aaaatattgt tgctctgaca aaaatacatg tatttcattc 2460 tcgtatggtg ctagagttag attaatctgc attttaaaaa actgaattgg aatagaattg 2520 gtaagttgca aagacttttt gaaaataatt aaattatcat atcttccatt cctgttattg 2580 gagatgaaaa taaaaagcaa cttatgaaag tagacattca gatccagcca ttactaacct 2640 attccttttt tggggaaatc tgagcctagc tcagaaaaac ataaagcacc ttgaaaaaga 2700 cttggcagct tcctgataaa gcgtgctgtg ctgtgcagta ggaacacatc ctatttattg 2760 tgatgttgtg gttttattat cttaaactct gttccataca cttgtataaa tacatggata 2820 tttttatgta cagaagtatg tctcttaacc agttcactta ttgtactctg gcaatttaaa 2880 agaaaatcag taaaatattt tgcttgtaaa atgcttaata tcgtgcctag gttatgtggt 2940 gactatttga atcaaaaatg tattgaatca tcaaataaaa gaatgtggct attttgggga 3000 gaaaatt 3007 <210> SEQ ID NO 59 <211> LENGTH: 1002 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 59 Met Ala Ala His Glu Trp Asp Trp Phe Gln Arg Glu Glu Leu Ile Gly 1 5 10 15 Gln Ile Ser Asp Ile Arg Val Gln Asn Leu Gln Val Glu Arg Glu Asn 20 25 30 Val Gln Lys Arg Thr Phe Thr Arg Trp Ile Asn Leu His Leu Glu Lys 35 40 45 Cys Asn Pro Pro Leu Glu Val Lys Asp Leu Phe Val Asp Ile Gln Asp 50 55 60 Gly Lys Ile Leu Met Ala Leu Leu Glu Val Leu Ser Gly Arg Asn Leu 65 70 75 80 Leu His Glu Tyr Lys Ser Ser Ser His Arg Ile Phe Arg Leu Asn Asn 85 90 95 Ile Ala Lys Ala Leu Lys Phe Leu Glu Asp Ser Asn Val Lys Leu Val 100 105 110 Ser Ile Asp Ala Ala Glu Ile Ala Asp Gly Asn Pro Ser Leu Val Leu 115 120 125 Gly Leu Ile Trp Asn Ile Ile Leu Phe Phe Gln Ile Lys Glu Leu Thr 130 135 140 Gly Asn Leu Ser Arg Asn Ser Pro Ser Ser Ser Leu Ser Pro Gly Ser 145 150 155 160 Gly Gly Thr Asp Ser Asp Ser Ser Phe Pro Pro Thr Pro Thr Ala Glu 165 170 175 Arg Ser Val Ala Ile Ser Val Lys Asp Gln Arg Lys Ala Ile Lys Ala 180 185 190 Leu Leu Ala Trp Val Gln Arg Lys Thr Arg Lys Tyr Gly Val Ala Val 195 200 205 Gln Asp Phe Ala Gly Ser Trp Arg Ser Gly Leu Ala Phe Leu Ala Val 210 215 220 Ile Lys Ala Ile Asp Pro Ser Leu Val Asp Met Lys Gln Ala Leu Glu 225 230 235 240 Asn Ser Thr Arg Glu Asn Leu Glu Lys Ala Phe Ser Ile Ala Gln Asp 245 250 255 Ala Leu His Ile Pro Arg Leu Leu Glu Pro Glu Asp Ile Met Val Asp 260 265 270 Thr Pro Asp Glu Gln Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Glu 275 280 285 Arg Phe Pro Glu Leu Glu Ala Glu Asp Ile Phe Asp Ser Asp Lys Glu 290 295 300 Val Pro Ile Glu Ser Thr Phe Val Arg Ile Lys Glu Thr Pro Ser Glu 305 310 315 320 Gln Glu Ser Lys Val Phe Val Leu Thr Glu Asn Gly Glu Arg Thr Tyr 325 330 335 Thr Val Asn His Glu Thr Ser His Pro Pro Pro Ser Lys Val Phe Val 340 345 350 Cys Asp Lys Pro Glu Ser Met Lys Glu Phe Arg Leu Asp Gly Val Ser 355 360 365 Ser His Ala Leu Ser Asp Ser Ser Thr Glu Phe Met His Gln Ile Ile 370 375 380 Asp Gln Val Leu Gln Gly Gly Pro Gly Lys Thr Ser Asp Ile Ser Glu 385 390 395 400 Pro Ser Pro Glu Ser Ser Ile Leu Ser Ser Arg Lys Glu Asn Gly Arg 405 410 415 Ser Asn Ser Leu Pro Ile Lys Lys Thr Val His Phe Glu Ala Asp Thr 420 425 430 Tyr Lys Asp Pro Phe Cys Ser Lys Asn Leu Ser Leu Cys Phe Glu Gly 435 440 445 Ser Pro Arg Val Ala Lys Glu Ser Leu Arg Gln Asp Gly His Val Leu 450 455 460 Ala Val Glu Val Ala Glu Glu Lys Glu Gln Lys Gln Glu Ser Ser Lys 465 470 475 480 Ile Pro Glu Ser Ser Ser Asp Lys Val Ala Gly Asp Ile Phe Leu Val 485 490 495 Glu Gly Thr Asn Asn Asn Ser Gln Ser Ser Ser Cys Asn Gly Ala Leu 500 505 510 Glu Ser Thr Ala Arg His Asp Glu Glu Ser His Ser Leu Ser Pro Pro 515 520 525 Gly Glu Asn Thr Val Met Ala Asp Ser Phe Gln Ile Lys Val Asn Leu 530 535 540 Met Thr Val Glu Ala Leu Glu Glu Gly Asp Tyr Phe Glu Ala Ile Pro 545 550 555 560 Leu Lys Ala Ser Lys Phe Asn Ser Asp Leu Ile Asp Phe Ala Ser Thr 565 570 575 Ser Gln Ala Phe Asn Lys Val Pro Ser Pro His Glu Thr Lys Pro Asp 580 585 590 Glu Asp Ala Glu Ala Phe Glu Asn His Ala Glu Lys Leu Gly Lys Arg 595 600 605 Ser Ile Lys Ser Ala His Lys Lys Lys Asp Ser Pro Glu Pro Gln Val 610 615 620 Lys Met Asp Lys His Glu Pro His Gln Asp Ser Gly Glu Glu Ala Glu 625 630 635 640 Gly Cys Pro Ser Ala Pro Glu Glu Thr Pro Val Asp Lys Lys Pro Glu 645 650 655 Val His Glu Lys Ala Lys Arg Lys Ser Thr Arg Pro His Tyr Glu Glu 660 665 670 Glu Gly Glu Asp Asp Asp Leu Gln Gly Val Gly Glu Glu Leu Ser Ser 675 680 685 Ser Pro Pro Ser Ser Cys Val Ser Leu Glu Thr Leu Gly Ser His Ser 690 695 700 Glu Glu Gly Leu Asp Phe Lys Pro Ser Pro Pro Leu Ser Lys Val Ser 705 710 715 720 Val Ile Pro His Asp Leu Phe Tyr Phe Pro His Tyr Glu Val Pro Leu 725 730 735 Ala Ala Val Leu Glu Ala Tyr Val Glu Asp Pro Glu Asp Leu Lys Asn 740 745 750 Glu Glu Met Asp Leu Glu Glu Pro Glu Gly Tyr Met Pro Asp Leu Asp 755 760 765 Ser Arg Glu Glu Glu Ala Asp Gly Ser Gln Ser Ser Ser Ser Ser Ser 770 775 780 Val Pro Gly Glu Ser Leu Pro Ser Ala Ser Asp Gln Val Leu Tyr Leu 785 790 795 800 Ser Arg Gly Gly Val Gly Thr Thr Pro Ala Ser Glu Pro Ala Pro Leu 805 810 815 Ala Pro His Glu Asp His Gln Gln Arg Glu Thr Lys Glu Asn Asp Pro 820 825 830 Met Asp Ser His Gln Ser Gln Glu Ser Pro Asn Leu Glu Asn Ile Ala 835 840 845 Asn Pro Leu Glu Glu Asn Val Thr Lys Glu Ser Ile Ser Ser Lys Lys 850 855 860 Lys Glu Lys Arg Lys His Val Asp His Val Glu Ser Ser Leu Phe Val 865 870 875 880 Ala Pro Gly Ser Val Gln Ser Ser Asp Asp Leu Glu Glu Asp Ser Ser 885 890 895 Asp Tyr Ser Ile Pro Ser Arg Thr Ser His Ser Asp Ser Ser Ile Tyr 900 905 910 Leu Arg Arg His Thr His Arg Ser Ser Glu Ser Asp His Phe Ser Tyr 915 920 925 Val Gln Leu Arg Asn Ala Ala Asp Leu Asp Asp Arg Arg Asn Arg Ile 930 935 940 Leu Thr Arg Lys Ala Asn Ser Ser Gly Glu Ala Met Ser Leu Gly Ser 945 950 955 960 His Ser Pro Gln Ser Asp Ser Leu Thr Gln Leu Val Gln Gln Pro Asp 965 970 975 Met Met Tyr Phe Ile Leu Phe Leu Trp Leu Leu Val Tyr Cys Leu Leu 980 985 990 Leu Phe Pro Gln Leu Asp Val Ser Arg Leu 995 1000 <210> SEQ ID NO 60 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 60 Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 1 5 10 15 Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 20 25 30 Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 35 40 45 Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 50 55 60 Ala Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp 65 70 75 80 Val Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala 85 90 95 Thr Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 100 105

<210> SEQ ID NO 61 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 61 Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 1 5 10 15 Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 20 25 30 Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 35 40 45 Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 50 55 60 Ala Gln Leu Gly Pro Leu Ser Pro Leu Pro Ile Cys Pro His Pro Cys 65 70 75 80 <210> SEQ ID NO 62 <211> LENGTH: 1357 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 62 Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile 1 5 10 15 Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr 20 25 30 Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile 35 40 45 Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys 50 55 60 Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val 65 70 75 80 Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln 85 90 95 Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg 100 105 110 Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln 115 120 125 Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu 130 135 140 Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala 145 150 155 160 Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp 165 170 175 Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu 180 185 190 Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys 195 200 205 Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp 210 215 220 Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala 225 230 235 240 Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys 245 250 255 Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys 260 265 270 Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu 275 280 285 Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val 290 295 300 Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys 305 310 315 320 Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu 325 330 335 Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys 340 345 350 Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg 355 360 365 Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu 370 375 380 Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu 385 390 395 400 Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu 405 410 415 Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala 420 425 430 Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu 435 440 445 Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu 450 455 460 Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu 465 470 475 480 Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg 485 490 495 Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu 500 505 510 Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu 515 520 525 Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln 530 535 540 Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg 545 550 555 560 Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu 565 570 575 Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile 580 585 590 Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val 595 600 605 Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala 610 615 620 Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile 625 630 635 640 Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala 645 650 655 Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln 660 665 670 Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln 675 680 685 Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn 690 695 700 Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu 705 710 715 720 Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys 725 730 735 Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu 740 745 750 Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile 755 760 765 Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala 770 775 780 Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys 785 790 795 800 Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu 805 810 815 Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln 820 825 830 Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val 835 840 845 Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu 850 855 860 Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys 865 870 875 880 Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp 885 890 895 Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln 900 905 910 Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe 915 920 925 Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg 930 935 940 Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr 945 950 955 960 Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln 965 970 975 Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro 980 985 990 Pro His Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile 995 1000 1005 Ser Gly Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu His 1010 1015 1020 Gln Arg Lys Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp Glu Ala Met 1025 1030 1035 1040 Glu Ala Leu Ala Ser Thr Glu Lys Met Leu Gln Asp Lys Val Asn Lys 1045 1050 1055 Thr Ser Lys Glu Arg Gln Gln Gln Val Glu Ala Val Glu Leu Glu Ala 1060 1065 1070 Lys Glu Val Leu Lys Lys Leu Phe Pro Lys Val Ser Val Pro Ser Asn 1075 1080 1085 Leu Ser Tyr Gly Glu Trp Leu His Gly Phe Glu Lys Lys Ala Lys Glu 1090 1095 1100 Cys Met Ala Gly Thr Ser Gly Ser Glu Glu Val Lys Val Leu Glu His 1105 1110 1115 1120 Lys Leu Lys Glu Ala Asp Glu Met His Thr Leu Leu Gln Leu Glu Cys 1125 1130 1135 Glu Lys Tyr Lys Ser Val Leu Ala Glu Thr Glu Gly Ile Leu Gln Lys 1140 1145 1150 Leu Gln Arg Ser Val Glu Gln Glu Glu Asn Lys Trp Lys Val Lys Val 1155 1160 1165 Asp Glu Ser His Lys Thr Ile Lys Gln Met Gln Ser Ser Phe Thr Ser 1170 1175 1180

Ser Glu Gln Glu Leu Glu Arg Leu Arg Ser Glu Asn Lys Asp Ile Glu 1185 1190 1195 1200 Asn Leu Arg Arg Glu Arg Glu His Leu Glu Met Glu Leu Glu Lys Ala 1205 1210 1215 Glu Met Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu Leu Lys Asp 1220 1225 1230 Leu Leu Thr Glu Leu Gln Lys Lys Leu Asp Asp Ser Tyr Ser Glu Ala 1235 1240 1245 Val Arg Gln Asn Glu Glu Leu Asn Leu Leu Lys Ala Gln Leu Asn Glu 1250 1255 1260 Thr Leu Thr Lys Leu Arg Thr Glu Gln Asn Glu Arg Gln Lys Val Ala 1265 1270 1275 1280 Gly Asp Leu His Lys Ala Gln Gln Ser Leu Glu Leu Ile Gln Ser Lys 1285 1290 1295 Ile Val Lys Ala Ala Gly Asp Thr Thr Val Ile Glu Asn Ser Asp Val 1300 1305 1310 Ser Pro Glu Thr Glu Ser Ser Glu Lys Glu Thr Met Ser Val Ser Leu 1315 1320 1325 Asn Gln Thr Val Thr Gln Leu Gln Gln Leu Leu Gln Ala Val Asn Gln 1330 1335 1340 Gln Leu Thr Lys Glu Lys Glu His Tyr Gln Val Leu Glu 1345 1350 1355 <210> SEQ ID NO 63 <211> LENGTH: 537 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 63 Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala 1 5 10 15 Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 20 25 30 Leu Phe Leu Asn Thr Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Thr 35 40 45 Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Thr Phe Ile 50 55 60 Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 65 70 75 80 Asp Ile Asp Asn Lys Thr Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 85 90 95 Glu Cys Glu Cys Thr Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Thr 100 105 110 Arg Pro Leu Val Met Lys Thr Gly Arg Pro Ala Gly Lys Gly Ser Ile 115 120 125 Thr Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 130 135 140 Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp 145 150 155 160 Pro Tyr Leu Glu Phe His Lys Gln Thr Ser Asp Gly Asn Trp Leu Met 165 170 175 Val His Arg Thr Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg 180 185 190 Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys 195 200 205 Thr Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp 210 215 220 Leu Ile Gly Thr Phe Gln Thr Thr Met Thr Lys Leu Lys Glu Ala Ser 225 230 235 240 Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln 245 250 255 Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys 260 265 270 Glu Ile Thr Val Glu Cys Thr Phe Leu Asp Tyr Ile Met Gly Gly Cys 275 280 285 Gln Leu Asn Phe Thr Val Gly Val Asp Phe Thr Gly Ser Asn Gly Asp 290 295 300 Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn 305 310 315 320 Glu Tyr Leu Thr Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr 325 330 335 Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro 340 345 350 Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser 355 360 365 Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser 370 375 380 Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Thr Asn Phe Ser Pro Ile 385 390 395 400 Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Thr Gln Gln Gln Thr 405 410 415 Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Thr Asp Gly Val Ile Thr 420 425 430 Asp Leu Asp Glu Thr Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro 435 440 445 Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met 450 455 460 Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu 465 470 475 480 Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln 485 490 495 Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro 500 505 510 Gln Gln Val Val Gly Tyr Phe Asn Thr Tyr Lys Leu Leu Pro Pro Lys 515 520 525 Asn Pro Ala Thr Lys Gln Gln Lys Gln 530 535 <210> SEQ ID NO 64 <211> LENGTH: 496 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 64 Met Ala Ser Ser Thr Gly Asp Arg Ser Gln Ala Val Arg His Gly Leu 1 5 10 15 Arg Ala Lys Val Leu Thr Leu Asp Gly Met Asn Pro Arg Val Arg Arg 20 25 30 Val Glu Tyr Ala Val Arg Gly Pro Ile Val Gln Arg Ala Leu Glu Leu 35 40 45 Glu Gln Glu Leu Arg Gln Gly Val Lys Lys Pro Phe Thr Glu Val Ile 50 55 60 Arg Ala Asn Ile Gly Asp Ala Gln Ala Met Gly Gln Arg Pro Ile Thr 65 70 75 80 Phe Leu Arg Gln Val Leu Ala Leu Cys Val Asn Pro Asp Leu Leu Ser 85 90 95 Ser Pro Asn Phe Pro Asp Asp Ala Lys Lys Arg Ala Glu Arg Ile Leu 100 105 110 Gln Ala Cys Gly Gly His Ser Leu Gly Ala Tyr Ser Val Ser Ser Gly 115 120 125 Ile Gln Leu Ile Arg Glu Asp Val Ala Arg Tyr Ile Glu Arg Arg Asp 130 135 140 Gly Gly Ile Pro Ala Asp Pro Asn Asn Val Phe Leu Ser Thr Gly Ala 145 150 155 160 Ser Asp Ala Ile Val Thr Val Leu Lys Leu Leu Val Ala Gly Glu Gly 165 170 175 His Thr Arg Thr Gly Val Leu Ile Pro Ile Pro Gln Tyr Pro Leu Tyr 180 185 190 Ser Ala Thr Leu Ala Glu Leu Gly Ala Val Gln Val Asp Tyr Tyr Leu 195 200 205 Asp Glu Glu Arg Ala Trp Ala Leu Asp Val Ala Glu Leu His Arg Ala 210 215 220 Leu Gly Gln Ala Arg Asp His Cys Arg Pro Arg Ala Leu Cys Val Ile 225 230 235 240 Asn Pro Gly Asn Pro Thr Gly Gln Val Gln Thr Arg Glu Cys Ile Glu 245 250 255 Ala Val Ile Arg Phe Ala Phe Glu Glu Arg Leu Phe Leu Leu Ala Asp 260 265 270 Glu Val Tyr Gln Asp Asn Val Tyr Ala Ala Gly Ser Gln Phe His Ser 275 280 285 Phe Lys Lys Val Leu Met Glu Met Gly Pro Pro Tyr Ala Gly Gln Gln 290 295 300 Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly Tyr Met Gly Glu Cys 305 310 315 320 Gly Phe Arg Gly Gly Tyr Val Glu Val Val Asn Met Asp Ala Ala Val 325 330 335 Gln Gln Gln Met Leu Lys Leu Met Ser Val Arg Leu Cys Pro Pro Val 340 345 350 Pro Gly Gln Ala Leu Leu Asp Leu Val Val Ser Pro Pro Ala Pro Thr 355 360 365 Asp Pro Ser Phe Ala Gln Phe Gln Ala Glu Lys Gln Ala Val Leu Ala 370 375 380 Glu Leu Ala Ala Lys Ala Lys Leu Thr Glu Gln Val Phe Asn Glu Ala 385 390 395 400 Pro Gly Ile Ser Cys Asn Pro Val Gln Gly Ala Met Tyr Ser Phe Pro 405 410 415 Arg Val Gln Leu Pro Pro Arg Ala Val Glu Arg Ala Gln Glu Leu Gly 420 425 430 Leu Ala Pro Asp Met Phe Phe Cys Leu Arg Leu Leu Glu Glu Thr Gly 435 440 445 Ile Cys Val Val Pro Gly Ser Gly Phe Gly Gln Arg Glu Gly Thr Tyr 450 455 460 His Phe Arg Met Thr Ile Leu Pro Pro Leu Glu Lys Leu Arg Leu Leu 465 470 475 480 Leu Glu Lys Leu Ser Arg Phe His Ala Lys Phe Thr Leu Glu Tyr Ser 485 490 495 <210> SEQ ID NO 65 <211> LENGTH: 2602 <212> TYPE: PRT <213> ORGANISM: Homo sapiens

<400> SEQUENCE: 65 Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 1 5 10 15 Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 20 25 30 Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 35 40 45 Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 50 55 60 Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 65 70 75 80 Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 85 90 95 Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 100 105 110 Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 115 120 125 Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 130 135 140 Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 145 150 155 160 Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 165 170 175 Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 180 185 190 Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 195 200 205 Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 210 215 220 Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 225 230 235 240 Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 245 250 255 Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 260 265 270 Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 275 280 285 Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 290 295 300 Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 305 310 315 320 Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 325 330 335 His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 340 345 350 Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 355 360 365 Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 370 375 380 Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 385 390 395 400 Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 405 410 415 Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 420 425 430 Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 435 440 445 Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 450 455 460 Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 465 470 475 480 Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 485 490 495 Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 500 505 510 Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 515 520 525 Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 530 535 540 Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 545 550 555 560 Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 565 570 575 Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 580 585 590 Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 595 600 605 Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 610 615 620 Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 625 630 635 640 Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 645 650 655 Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 660 665 670 Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 675 680 685 Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 690 695 700 Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 705 710 715 720 Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 725 730 735 Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 740 745 750 Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 755 760 765 Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 770 775 780 Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 785 790 795 800 His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 805 810 815 Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 820 825 830 Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 835 840 845 Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 850 855 860 Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 865 870 875 880 Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 885 890 895 Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 900 905 910 Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 915 920 925 Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 930 935 940 Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 945 950 955 960 Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 965 970 975 Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 980 985 990 Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro 995 1000 1005 Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro 1010 1015 1020 Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro 1025 1030 1035 1040 Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly 1045 1050 1055 Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly 1060 1065 1070 Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser 1075 1080 1085 Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro 1090 1095 1100 Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly 1105 1110 1115 1120 Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val 1125 1130 1135 Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly 1140 1145 1150 Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu 1155 1160 1165 Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn 1170 1175 1180 Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly 1185 1190 1195 1200 Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe 1205 1210 1215 Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys 1220 1225 1230 Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr 1235 1240 1245 Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp 1250 1255 1260 His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys 1265 1270 1275 1280 Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro 1285 1290 1295 Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro 1300 1305 1310 Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro 1315 1320 1325

Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn 1330 1335 1340 Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly 1345 1350 1355 1360 Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg 1365 1370 1375 Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro 1380 1385 1390 Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly 1395 1400 1405 Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val 1410 1415 1420 Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu 1425 1430 1435 1440 Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu 1445 1450 1455 Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val 1460 1465 1470 Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu 1475 1480 1485 Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg 1490 1495 1500 Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val 1505 1510 1515 1520 Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu 1525 1530 1535 Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu 1540 1545 1550 Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val 1555 1560 1565 His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys 1570 1575 1580 Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro 1585 1590 1595 1600 Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys 1605 1610 1615 Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu 1620 1625 1630 Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val 1635 1640 1645 Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val 1650 1655 1660 Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys 1665 1670 1675 1680 Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro 1685 1690 1695 Asn Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val 1700 1705 1710 Glu Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val 1715 1720 1725 Thr Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe 1730 1735 1740 Lys Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile 1745 1750 1755 1760 Thr Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile 1765 1770 1775 Val Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu 1780 1785 1790 Val Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro 1795 1800 1805 Glu Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val 1810 1815 1820 Ser Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala 1825 1830 1835 1840 Thr Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu 1845 1850 1855 Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys 1860 1865 1870 Asp Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr 1875 1880 1885 Ser Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe 1890 1895 1900 Thr Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu 1905 1910 1915 1920 Gly Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser 1925 1930 1935 Ser Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys 1940 1945 1950 Leu Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro 1955 1960 1965 Arg Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His 1970 1975 1980 Val Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly 1985 1990 1995 2000 Asp Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg 2005 2010 2015 Thr Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr 2020 2025 2030 Gly Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln 2035 2040 2045 Thr Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr 2050 2055 2060 Val Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val 2065 2070 2075 2080 Pro Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys 2085 2090 2095 Glu Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly 2100 2105 2110 Ser Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp 2115 2120 2125 Met Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu 2130 2135 2140 Ile Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln 2145 2150 2155 2160 Glu Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val 2165 2170 2175 Thr Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly 2180 2185 2190 Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala 2195 2200 2205 Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly 2210 2215 2220 Gly Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe 2225 2230 2235 2240 Asp Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu 2245 2250 2255 Pro Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro 2260 2265 2270 Glu Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg 2275 2280 2285 Arg Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln 2290 2295 2300 Pro Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp 2305 2310 2315 2320 Ala Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser 2325 2330 2335 Glu Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn 2340 2345 2350 Gly Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly 2355 2360 2365 Ser Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro 2370 2375 2380 Ala Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly 2385 2390 2395 2400 Ile Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr 2405 2410 2415 Leu Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln 2420 2425 2430 Glu Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly 2435 2440 2445 Asn Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly 2450 2455 2460 Ser Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly 2465 2470 2475 2480 Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser 2485 2490 2495 Ser Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala 2500 2505 2510 Ser Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly 2515 2520 2525 Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met 2530 2535 2540 Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser 2545 2550 2555 2560 Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys 2565 2570 2575 Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile 2580 2585 2590 Pro Gly Ser Pro Phe His Val Thr Val Pro 2595 2600 <210> SEQ ID NO 66 <211> LENGTH: 686 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 66 Met Met Ile Gln Trp Asn Gly Pro Lys Thr Ser Ile Ser Glu Lys Ala 1 5 10 15

Arg Gly Leu Ala Leu Thr Tyr Ser Leu Arg Asp Arg Glu Arg Gly Gly 20 25 30 Gly Arg Ala Gln Ile Gly Val Val Asp Asp Glu Ala Lys Ala Pro Asp 35 40 45 Leu Met Gln Ile Met Glu Ala Val Leu Gly Cys Arg Val Gly Ser Leu 50 55 60 Arg Ala Ala Thr Pro Ser Lys Asp Ile Asn Gln Leu Gln Lys Ala Asn 65 70 75 80 Val Arg Leu Tyr His Val Tyr Glu Lys Gly Lys Asp Leu Val Val Leu 85 90 95 Glu Leu Ala Thr Pro Pro Leu Thr Gln Asp Leu Leu Gln Glu Glu Asp 100 105 110 Phe Tyr Ile Leu Asp Gln Gly Gly Phe Lys Ile Tyr Val Trp Gln Gly 115 120 125 Arg Met Ser Ser Leu Gln Glu Arg Lys Ala Ala Phe Ser Arg Ala Val 130 135 140 Gly Phe Ile Gln Ala Lys Gly Tyr Pro Thr Tyr Thr Asn Val Glu Val 145 150 155 160 Val Asn Asp Gly Ala Glu Ser Ala Ala Phe Lys Gln Leu Phe Arg Thr 165 170 175 Trp Ser Glu Lys Arg Arg Arg Asn Gln Lys Leu Gly Gly Arg Asp Lys 180 185 190 Ser Ile His Val Lys Leu Asp Val Gly Lys Leu His Thr Gln Pro Lys 195 200 205 Leu Ala Ala Gln Leu Arg Met Val Asp Asp Gly Ser Gly Lys Val Glu 210 215 220 Val Trp Cys Ile Gln Asp Leu His Arg Gln Pro Val Asp Pro Lys Arg 225 230 235 240 His Gly Gln Leu Cys Ala Gly Asn Cys Tyr Leu Val Leu Tyr Thr Tyr 245 250 255 Gln Arg Leu Gly Arg Val Gln Tyr Ile Leu Tyr Leu Trp Gln Gly His 260 265 270 Gln Ala Thr Ala Asp Glu Ile Glu Ala Leu Asn Ser Asn Ala Glu Glu 275 280 285 Leu Asp Val Met Tyr Gly Gly Val Leu Val Gln Glu His Val Thr Met 290 295 300 Gly Ser Glu Pro Pro His Phe Leu Ala Ile Phe Gln Gly Gln Leu Val 305 310 315 320 Ile Phe Gln Glu Arg Ala Gly His His Gly Lys Gly Gln Ser Ala Ser 325 330 335 Thr Thr Arg Leu Phe Gln Val Gln Gly Thr Asp Ser His Asn Thr Arg 340 345 350 Thr Met Glu Val Pro Ala Arg Ala Ser Ser Leu Asn Ser Ser Asp Ile 355 360 365 Phe Leu Leu Val Thr Ala Ser Val Cys Tyr Leu Trp Phe Gly Lys Gly 370 375 380 Cys Asn Gly Asp Gln Arg Glu Met Ala Arg Val Val Val Thr Val Ile 385 390 395 400 Ser Arg Lys Asn Glu Glu Thr Val Leu Glu Gly Gln Glu Pro Pro His 405 410 415 Phe Trp Glu Ala Leu Gly Gly Arg Ala Pro Tyr Pro Ser Asn Lys Arg 420 425 430 Leu Pro Glu Glu Val Pro Ser Phe Gln Pro Arg Leu Phe Glu Cys Ser 435 440 445 Ser His Met Gly Cys Leu Val Leu Ala Glu Val Gly Phe Phe Ser Gln 450 455 460 Glu Asp Leu Asp Lys Tyr Asp Ile Met Leu Leu Asp Thr Trp Gln Glu 465 470 475 480 Ile Phe Leu Trp Leu Gly Glu Ala Ala Ser Glu Trp Lys Glu Ala Val 485 490 495 Ala Trp Gly Gln Glu Tyr Leu Lys Thr His Pro Ala Gly Arg Ser Pro 500 505 510 Ala Thr Pro Ile Val Leu Val Lys Gln Gly His Glu Pro Pro Thr Phe 515 520 525 Ile Gly Trp Phe Phe Thr Trp Asp Pro Tyr Lys Trp Thr Ser His Pro 530 535 540 Ser His Lys Glu Val Val Asp Gly Ser Pro Ala Ala Ala Ser Thr Ile 545 550 555 560 Ser Glu Ile Thr Ala Glu Val Asn Asn Leu Arg Leu Ser Arg Trp Pro 565 570 575 Gly Asn Gly Arg Ala Gly Ala Val Ala Leu Gln Ala Leu Lys Gly Ser 580 585 590 Gln Asp Ser Ser Glu Asn Asp Leu Val Arg Ser Pro Lys Ser Ala Gly 595 600 605 Ser Arg Thr Ser Ser Ser Val Ser Ser Thr Ser Ala Thr Ile Asn Gly 610 615 620 Gly Leu Arg Arg Glu Gln Leu Met His Gln Ala Val Glu Asp Leu Pro 625 630 635 640 Glu Gly Val Asp Pro Ala Arg Arg Glu Phe Tyr Leu Ser Asp Ser Asp 645 650 655 Phe Gln Asp Ile Phe Gly Lys Ser Lys Glu Glu Phe Tyr Ser Met Ala 660 665 670 Thr Trp Arg Gln Arg Gln Glu Lys Lys Gln Leu Gly Phe Phe 675 680 685 <210> SEQ ID NO 67 <211> LENGTH: 342 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 67 Met Ser Ser Ser Gly Thr Leu Ser Asn Tyr Tyr Val Asp Ser Leu Ile 1 5 10 15 Gly His Glu Gly Asp Glu Val Phe Ala Ala Arg Phe Gly Pro Pro Gly 20 25 30 Pro Gly Ala Gln Gly Arg Pro Ala Gly Val Ala Asp Gly Pro Ala Ala 35 40 45 Thr Ala Ala Glu Phe Ala Ser Cys Ser Phe Ala Pro Arg Ser Ala Val 50 55 60 Phe Ser Ala Ser Trp Ser Ala Val Pro Ser Gln Pro Pro Ala Ala Ala 65 70 75 80 Ala Met Ser Gly Leu Tyr His Pro Tyr Val Pro Pro Pro Pro Leu Ala 85 90 95 Ala Ser Ala Ser Glu Pro Gly Arg Tyr Val Arg Ser Trp Met Glu Pro 100 105 110 Leu Pro Gly Phe Pro Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 115 120 125 Gly Gly Pro Gly Arg Gly Pro Ser Pro Gly Pro Ser Gly Pro Ala Asn 130 135 140 Gly Arg His Tyr Gly Ile Lys Pro Glu Thr Arg Ala Ala Pro Ala Pro 145 150 155 160 Ala Thr Ala Ala Ser Thr Thr Ser Ser Ser Ser Thr Ser Leu Ser Ser 165 170 175 Ser Ser Lys Arg Thr Glu Cys Ser Val Ala Arg Glu Ser Gln Gly Ser 180 185 190 Ser Gly Pro Glu Phe Ser Cys Asn Ser Phe Leu Gln Glu Lys Ala Ala 195 200 205 Ala Ala Thr Gly Gly Thr Gly Pro Gly Ala Gly Ile Gly Ala Ala Thr 210 215 220 Gly Thr Gly Gly Ser Ser Glu Pro Ser Ala Cys Ser Asp His Pro Ile 225 230 235 240 Pro Gly Cys Ser Leu Lys Glu Glu Glu Lys Gln His Ser Gln Pro Gln 245 250 255 Gln Gln Gln Leu Asp Pro Asn Asn Pro Ala Ala Asn Trp Ile His Ala 260 265 270 Arg Ser Thr Arg Lys Lys Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu 275 280 285 Glu Leu Glu Lys Glu Phe Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg 290 295 300 Arg Tyr Glu Val Ala Arg Ile Leu Asn Leu Thr Glu Arg Gln Val Lys 305 310 315 320 Ile Trp Phe Gln Asn Arg Arg Met Lys Met Lys Lys Met Ser Lys Glu 325 330 335 Lys Cys Pro Lys Gly Asp 340 <210> SEQ ID NO 68 <211> LENGTH: 1719 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 68 Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 1 5 10 15 Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu 20 25 30 Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 35 40 45 Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr 50 55 60 Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 65 70 75 80 Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 85 90 95 Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 100 105 110 Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val 115 120 125 Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe 130 135 140 Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 145 150 155 160 Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 165 170 175 Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 180 185 190 His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 195 200 205 Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 210 215 220 Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr

225 230 235 240 Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 245 250 255 Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 260 265 270 Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val 275 280 285 Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 290 295 300 Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 305 310 315 320 Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 325 330 335 Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 340 345 350 Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr 355 360 365 Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met 370 375 380 Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val 385 390 395 400 Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 405 410 415 Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln 420 425 430 Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile 435 440 445 Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 450 455 460 Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro 465 470 475 480 Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 485 490 495 Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln 500 505 510 Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 515 520 525 Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg 530 535 540 Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 545 550 555 560 Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 565 570 575 Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Thr Glu Leu His Thr Gln 580 585 590 Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 595 600 605 Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Thr 610 615 620 Glu Arg Ala Lys Lys Glu Leu Glu Val His Thr Glu Ala Leu Ala Ala 625 630 635 640 Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 645 650 655 Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 660 665 670 Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys 675 680 685 Leu Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 690 695 700 Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 705 710 715 720 Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 725 730 735 Met Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser 740 745 750 Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 755 760 765 Lys Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp 770 775 780 Lys Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 785 790 795 800 Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 805 810 815 Trp Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 820 825 830 Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu 835 840 845 Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met 850 855 860 Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 865 870 875 880 Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 885 890 895 Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys 900 905 910 Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 915 920 925 Glu Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile 930 935 940 Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro 945 950 955 960 Thr Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser 965 970 975 Val His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly 980 985 990 Phe Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr 995 1000 1005 Thr Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile 1010 1015 1020 Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr 1025 1030 1035 1040 Cys Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr 1045 1050 1055 Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr 1060 1065 1070 Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp 1075 1080 1085 Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp 1090 1095 1100 Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val 1105 1110 1115 1120 Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser 1125 1130 1135 Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val 1140 1145 1150 Thr Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met 1155 1160 1165 Leu Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser 1170 1175 1180 Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val 1185 1190 1195 1200 Tyr Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr 1205 1210 1215 Thr Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn 1220 1225 1230 Glu Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg 1235 1240 1245 Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp 1250 1255 1260 Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe 1265 1270 1275 1280 Pro Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser 1285 1290 1295 Glu Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly 1300 1305 1310 Ala Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr 1315 1320 1325 Glu Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln 1330 1335 1340 Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys 1345 1350 1355 1360 Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly 1365 1370 1375 Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile 1380 1385 1390 Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys 1395 1400 1405 Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln 1410 1415 1420 Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser 1425 1430 1435 1440 Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala 1445 1450 1455 Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro 1460 1465 1470 Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu 1475 1480 1485 Gly Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu 1490 1495 1500 Gly Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln 1505 1510 1515 1520 Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro 1525 1530 1535 Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu 1540 1545 1550 Met Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala 1555 1560 1565

His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met 1570 1575 1580 Asn Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser 1585 1590 1595 1600 Ile Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser 1605 1610 1615 Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala 1620 1625 1630 Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro 1635 1640 1645 Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln 1650 1655 1660 Gly Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser 1665 1670 1675 1680 Pro Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro 1685 1690 1695 Ser Pro Ala Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr 1700 1705 1710 Asp Arg Gly Ser Trp Asp Pro 1715 <210> SEQ ID NO 69 <211> LENGTH: 1638 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 69 Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 1 5 10 15 Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu 20 25 30 Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 35 40 45 Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr 50 55 60 Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 65 70 75 80 Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 85 90 95 Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 100 105 110 Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val 115 120 125 Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe 130 135 140 Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 145 150 155 160 Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 165 170 175 Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 180 185 190 His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 195 200 205 Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 210 215 220 Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr 225 230 235 240 Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 245 250 255 Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 260 265 270 Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val 275 280 285 Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 290 295 300 Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 305 310 315 320 Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 325 330 335 Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 340 345 350 Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr 355 360 365 Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met 370 375 380 Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val 385 390 395 400 Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 405 410 415 Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln 420 425 430 Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile 435 440 445 Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 450 455 460 Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro 465 470 475 480 Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 485 490 495 Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln 500 505 510 Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 515 520 525 Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg 530 535 540 Glu Asp Leu Asn Lys Leu Glu Val His Thr Glu Ala Leu Ala Ala Glu 545 550 555 560 Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser Lys 565 570 575 Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser Tyr 580 585 590 Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys Leu 595 600 605 Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu Ser 610 615 620 Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu 625 630 635 640 Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met 645 650 655 Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser Glu 660 665 670 Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys 675 680 685 Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp Lys 690 695 700 Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu 705 710 715 720 Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp 725 730 735 Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp 740 745 750 Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu 755 760 765 Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met Pro 770 775 780 Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu 785 790 795 800 Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln 805 810 815 Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys Lys 820 825 830 Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu 835 840 845 Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu 850 855 860 His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro Thr 865 870 875 880 Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser Val 885 890 895 His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly Phe 900 905 910 Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr Thr 915 920 925 Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile Arg 930 935 940 Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr Cys 945 950 955 960 Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr Lys 965 970 975 Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr Glu 980 985 990 Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp Gln 995 1000 1005 Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp Ile 1010 1015 1020 Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val Ile 1025 1030 1035 1040 Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp 1045 1050 1055 Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val Thr 1060 1065 1070 Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met Leu 1075 1080 1085 Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser Glu 1090 1095 1100 Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val Tyr 1105 1110 1115 1120 Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr Thr 1125 1130 1135

Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn Glu 1140 1145 1150 Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg Val 1155 1160 1165 Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp Gln 1170 1175 1180 Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe Pro 1185 1190 1195 1200 Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser Glu 1205 1210 1215 Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly Ala 1220 1225 1230 Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr Glu 1235 1240 1245 Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln Val 1250 1255 1260 Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys Val 1265 1270 1275 1280 Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly Asn 1285 1290 1295 Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile Ala 1300 1305 1310 His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys Glu 1315 1320 1325 Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln Gly 1330 1335 1340 Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser Ser 1345 1350 1355 1360 Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala Val 1365 1370 1375 Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro Leu 1380 1385 1390 Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu Gly 1395 1400 1405 Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu Gly 1410 1415 1420 Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln Met 1425 1430 1435 1440 Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro Glu 1445 1450 1455 Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu Met 1460 1465 1470 Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala His 1475 1480 1485 Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met Asn 1490 1495 1500 Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser Ile 1505 1510 1515 1520 Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser Ala 1525 1530 1535 Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala Leu 1540 1545 1550 Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro Met 1555 1560 1565 Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln Gly 1570 1575 1580 Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser Pro 1585 1590 1595 1600 Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro Ser 1605 1610 1615 Pro Ala Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr Asp 1620 1625 1630 Arg Gly Ser Trp Asp Pro 1635 <210> SEQ ID NO 70 <211> LENGTH: 152 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met Ser His Val Leu Phe Ser Gly Arg Met Phe Ala Gly Leu Ala Gln 1 5 10 15 Asp Phe Arg Trp Ser Ala Ser Ser Phe Leu Ile Pro Cys Asp Cys Cys 20 25 30 Val Gly Lys Gln Arg Val Lys Cys Cys Arg Arg Thr Trp Glu Ser Phe 35 40 45 Cys Phe Glu Gly Pro Leu Glu Gln Glu Lys Leu Glu Ser Leu Ser Leu 50 55 60 Arg Ser Gln Asn Arg His Glu Asp Met Val Pro Ile Pro Leu Val Leu 65 70 75 80 Lys Gly Thr Pro Gly Glu Phe Gln Glu Thr Pro Pro Phe Leu Val Phe 85 90 95 Ile Leu Thr Pro Ser Pro Arg His Leu Ser Pro Gln Val His Thr Gln 100 105 110 Glu Gly Gly Ile Phe Tyr Leu Phe Arg Ser Gly Gln Gln Pro Val Gly 115 120 125 Asn Val Ile Ser Val Gly Thr Gly His Gly Thr Lys Pro Ser Trp Cys 130 135 140 Leu Asp Cys Asn Leu Ala Glu Ser 145 150 <210> SEQ ID NO 71 <211> LENGTH: 596 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 71 Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 1 5 10 15 Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 20 25 30 Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 35 40 45 Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 50 55 60 Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 65 70 75 80 Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 85 90 95 Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 100 105 110 Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr 115 120 125 Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln 130 135 140 Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile 145 150 155 160 Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro 165 170 175 Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn 180 185 190 Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro 195 200 205 Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro 210 215 220 Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Leu Val Pro Gln 225 230 235 240 Gln Gly Gln Pro Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro 245 250 255 Tyr Pro Thr Ala Leu Thr Val Asn Ala Ser Val Ser Arg Phe Pro Pro 260 265 270 His Met Val Pro Pro His His Thr Leu His Thr Thr Gly Ile Pro His 275 280 285 Pro Ala Ile Val Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp 290 295 300 Val Gly Ser Leu His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu 305 310 315 320 Glu Lys Lys Lys Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu 325 330 335 Tyr Met Lys Glu Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys 340 345 350 Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu 355 360 365 Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg 370 375 380 Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr 385 390 395 400 Gly Lys Lys Lys Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn 405 410 415 Glu His Ser Glu Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile 420 425 430 Thr Asp Leu Ser Ala Pro Lys Lys Cys Arg Ala Arg Phe Gly Leu Asp 435 440 445 Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys Cys Val 450 455 460 Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu Ser Pro Pro Ser Ser Asp 465 470 475 480 Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser Pro Asn Leu Leu Gly Ser 485 490 495 Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu Gln Thr Gln Pro Leu Ser 500 505 510 Leu Ser Leu Lys Pro Asp Pro Leu Ala His Leu Ser Met Met Pro Pro 515 520 525 Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr His Lys Ala Ser Ala Leu 530 535 540 Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro Ala Ala Leu Gln Pro Ala 545 550 555 560 Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser Thr Ser Trp Leu His Ser 565 570 575 His Ser Ser Leu Ala Gly Thr Gln Pro Gln Pro Leu Ser Leu Val Thr

580 585 590 Lys Ser Leu Glu 595 <210> SEQ ID NO 72 <211> LENGTH: 313 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 1 5 10 15 Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 20 25 30 Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 35 40 45 Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 50 55 60 Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 65 70 75 80 Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 85 90 95 Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 100 105 110 His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 115 120 125 Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 130 135 140 Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 145 150 155 160 Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 165 170 175 Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 180 185 190 Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 195 200 205 Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 210 215 220 Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 225 230 235 240 Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 245 250 255 Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 260 265 270 Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 275 280 285 Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 290 295 300 Ala Thr Ala Gly Thr Ala Ser Pro Pro 305 310 <210> SEQ ID NO 73 <211> LENGTH: 424 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 73 Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 1 5 10 15 Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 20 25 30 Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 35 40 45 Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 50 55 60 Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 65 70 75 80 Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 85 90 95 Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 100 105 110 Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 115 120 125 Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 130 135 140 Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn 145 150 155 160 Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp 165 170 175 Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe 180 185 190 Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln 195 200 205 Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val 210 215 220 Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile 225 230 235 240 Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly 245 250 255 Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala 260 265 270 Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala 275 280 285 Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu 290 295 300 Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly 305 310 315 320 Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val 325 330 335 Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala 340 345 350 Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro 355 360 365 Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala 370 375 380 Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg 385 390 395 400 Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala 405 410 415 Ala Val Phe Glu Tyr Pro Gly Asn 420 <210> SEQ ID NO 74 <211> LENGTH: 333 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 74 Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 1 5 10 15 Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 20 25 30 Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 35 40 45 Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 50 55 60 Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 65 70 75 80 Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 85 90 95 Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 100 105 110 Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 115 120 125 Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 130 135 140 Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 145 150 155 160 Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 165 170 175 Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 180 185 190 Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 195 200 205 Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 210 215 220 Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 245 250 255 Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 275 280 285 Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 290 295 300 Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 305 310 315 320 Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 325 330 <210> SEQ ID NO 75 <211> LENGTH: 545 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 75 Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 1 5 10 15 Met Arg Asn Thr Ser Thr Met Ile Gly Val Gly Ser Lys Asp Ala Gly 20 25 30 Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 35 40 45 Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr

50 55 60 Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 65 70 75 80 Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 85 90 95 Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 100 105 110 Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 115 120 125 Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 130 135 140 Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 145 150 155 160 Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 165 170 175 Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 180 185 190 Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 195 200 205 Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 210 215 220 Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 225 230 235 240 Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 245 250 255 Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 260 265 270 Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 275 280 285 Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 290 295 300 Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 305 310 315 320 Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 325 330 335 Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 340 345 350 Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 355 360 365 Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 370 375 380 Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 385 390 395 400 Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 405 410 415 Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 420 425 430 Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp 435 440 445 Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr 450 455 460 Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly 465 470 475 480 Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp 485 490 495 Phe Leu Asn Arg Cys Leu Asp Met Asp Val Glu Lys Arg Gly Ser Ala 500 505 510 Lys Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser 515 520 525 Ser Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn 530 535 540 His 545 <210> SEQ ID NO 76 <211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 1 5 10 15 Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 20 25 30 Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 35 40 45 Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 50 55 60 Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 65 70 75 80 Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 85 90 95 Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 100 105 110 Ala Ala Lys 115 <210> SEQ ID NO 77 <211> LENGTH: 414 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 77 Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 1 5 10 15 Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 20 25 30 Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 35 40 45 Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 50 55 60 Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 65 70 75 80 Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 85 90 95 Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 100 105 110 Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 115 120 125 Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 130 135 140 Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 145 150 155 160 Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 165 170 175 Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 180 185 190 His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 195 200 205 Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 210 215 220 Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 225 230 235 240 Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 245 250 255 Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 260 265 270 Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 275 280 285 Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly 290 295 300 Val Ser Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu 305 310 315 320 Gln Gly Gln Ser Thr Ala Met Ala Ala Thr Gly Asp Val Ala Leu Leu 325 330 335 Arg His Ser Lys Leu Leu Ala Glu Pro Ala Gly Gly Leu Val Gly Glu 340 345 350 Arg Thr Cys Ser Ala Ser Pro Gly Cys Cys Gly Ser Met Met Gly Gln 355 360 365 Asp Ala Pro Trp Lys Ala Glu Ala Asp Ala Gly Gly Thr Ala Lys Leu 370 375 380 Pro His Gln Arg Leu Gly Cys Asn Ala Gly Val Ser Pro Ser Phe Gln 385 390 395 400 Gln His Cys Val Ala Ser Leu Ala Thr Lys Ala Ser Ser Gln 405 410 <210> SEQ ID NO 78 <211> LENGTH: 1043 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 1 5 10 15 Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr 20 25 30 Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile Ser Val 35 40 45 Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 50 55 60 Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 65 70 75 80 Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 85 90 95 Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 100 105 110 Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 115 120 125 Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 130 135 140 Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 145 150 155 160

Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 165 170 175 Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 180 185 190 Lys Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 195 200 205 Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 210 215 220 Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp Asp 225 230 235 240 Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 245 250 255 Ser Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 260 265 270 Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile 275 280 285 Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 290 295 300 Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 305 310 315 320 Thr Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 325 330 335 Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg 340 345 350 Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 355 360 365 Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 370 375 380 Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 385 390 395 400 Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu Glu 405 410 415 Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 420 425 430 Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 435 440 445 Ile Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 450 455 460 Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly 465 470 475 480 His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 485 490 495 Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 500 505 510 Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 515 520 525 Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu Arg 530 535 540 Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 545 550 555 560 Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 565 570 575 Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 580 585 590 Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 595 600 605 Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 610 615 620 Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 625 630 635 640 Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly 645 650 655 Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 660 665 670 Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 675 680 685 Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 690 695 700 Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 705 710 715 720 Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 725 730 735 Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 740 745 750 Phe Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 755 760 765 Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val 770 775 780 Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 785 790 795 800 Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 805 810 815 Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 820 825 830 Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu 835 840 845 Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 850 855 860 Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 865 870 875 880 Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 885 890 895 Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser Arg 900 905 910 Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 915 920 925 Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 930 935 940 Val Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 945 950 955 960 Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His Val 965 970 975 Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 980 985 990 Arg Gln Leu Thr Val Thr Val Thr Glu Lys Phe Ser Val Arg Phe Lys 995 1000 1005 Glu Asn Ser Val Ala Val Lys Val Val Gln Gly Pro Ala Gly Gly Asp 1010 1015 1020 Asn Ser Lys Leu Arg Tyr Lys Lys Lys Gly Ser His Cys Leu Glu Val 1025 1030 1035 1040 Thr Val Gln <210> SEQ ID NO 79 <211> LENGTH: 638 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Met Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu 1 5 10 15 Leu Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys 20 25 30 Lys Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu 35 40 45 Ile Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met 50 55 60 Glu Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg 65 70 75 80 Asp Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu 85 90 95 Arg Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu 100 105 110 Arg Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 115 120 125 Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg 130 135 140 Asp Arg Asp Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg 145 150 155 160 Asp Arg Asp Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys Asp Arg 165 170 175 Ser Arg Ser Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg Glu Arg 180 185 190 Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 195 200 205 Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys 210 215 220 Lys Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys 225 230 235 240 Leu Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu 245 250 255 Lys Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys 260 265 270 Glu Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala 275 280 285 Lys Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp 290 295 300 Pro Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg 305 310 315 320 Glu Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu 325 330 335 Glu Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp 340 345 350 Pro Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg 355 360 365 Gln Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu 370 375 380 Lys Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu 385 390 395 400 Glu Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser

405 410 415 Ser Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr 420 425 430 Pro Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser 435 440 445 Pro Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser 450 455 460 Leu Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys 465 470 475 480 Arg Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu 485 490 495 Asp Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr 500 505 510 Gly Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu 515 520 525 Lys Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys 530 535 540 Pro Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile 545 550 555 560 Leu Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu 565 570 575 Tyr Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys 580 585 590 Val Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met 595 600 605 Val Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu 610 615 620 Leu Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 625 630 635 <210> SEQ ID NO 80 <211> LENGTH: 940 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 1 5 10 15 Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 20 25 30 Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 35 40 45 Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 50 55 60 Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 65 70 75 80 Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 85 90 95 Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 100 105 110 Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 115 120 125 Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 130 135 140 Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 145 150 155 160 Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 165 170 175 Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 180 185 190 Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 195 200 205 Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 210 215 220 Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 225 230 235 240 Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 245 250 255 Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 260 265 270 Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 275 280 285 Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 290 295 300 Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 305 310 315 320 Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 325 330 335 Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 340 345 350 Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 355 360 365 Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 370 375 380 Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 385 390 395 400 Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 405 410 415 Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 420 425 430 Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 435 440 445 Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 450 455 460 Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 465 470 475 480 Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 485 490 495 Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 500 505 510 Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 515 520 525 Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 530 535 540 Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 545 550 555 560 Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 565 570 575 Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 580 585 590 Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 595 600 605 Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 610 615 620 Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 625 630 635 640 Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 645 650 655 Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 660 665 670 Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 675 680 685 Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 690 695 700 Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 705 710 715 720 Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 725 730 735 Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 740 745 750 Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 755 760 765 Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 770 775 780 Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 785 790 795 800 Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 805 810 815 Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 820 825 830 Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 835 840 845 Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 850 855 860 Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 865 870 875 880 Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 885 890 895 Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 900 905 910 Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 915 920 925 Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 930 935 940 <210> SEQ ID NO 81 <211> LENGTH: 953 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 81 Met Ala Glu Thr Leu Pro Gly Ser Gly Asp Ser Gly Pro Gly Thr Ala 1 5 10 15 Ser Leu Gly Pro Gly Val Ala Glu Thr Gly Thr Arg Arg Leu Ser Glu 20 25 30 Leu Arg Val Ile Asp Leu Arg Ala Glu Leu Lys Lys Arg Asn Leu Asp 35 40 45 Thr Gly Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys Lys Ala Val 50 55 60 Lys Glu Glu Gly Gln Asp Pro Asp Glu Ile Gly Ile Glu Leu Glu Ala 65 70 75 80

Thr Ser Lys Lys Ser Ala Lys Arg Cys Val Lys Gly Leu Lys Met Glu 85 90 95 Glu Glu Gly Thr Glu Asp Asn Gly Leu Glu Asp Asp Ser Arg Asp Gly 100 105 110 Gln Glu Asp Met Glu Ala Ser Leu Glu Asn Leu Gln Asn Met Gly Met 115 120 125 Met Asp Met Ser Val Leu Asp Glu Thr Glu Val Ala Asn Ser Ser Ala 130 135 140 Pro Asp Phe Gly Glu Asp Gly Thr Asp Gly Leu Leu Asp Ser Phe Cys 145 150 155 160 Asp Ser Lys Glu Tyr Val Ala Ala Gln Leu Arg Gln Leu Pro Ala Gln 165 170 175 Pro Pro Glu His Ala Val Asp Gly Glu Gly Phe Lys Asn Thr Leu Glu 180 185 190 Thr Ser Ser Leu Asn Phe Lys Val Thr Pro Asp Ile Glu Glu Ser Leu 195 200 205 Leu Glu Pro Glu Asn Glu Lys Ile Leu Asp Ile Leu Gly Glu Thr Cys 210 215 220 Lys Ser Glu Pro Val Lys Glu Glu Ser Ser Glu Leu Glu Gln Pro Phe 225 230 235 240 Ala Gln Asp Thr Ser Ser Val Gly Pro Asp Arg Lys Leu Ala Glu Glu 245 250 255 Glu Asp Leu Phe Asp Ser Ala His Pro Glu Glu Gly Asp Leu Asp Leu 260 265 270 Ala Ser Glu Ser Thr Ala His Ala Gln Ser Ser Lys Ala Asp Ser Leu 275 280 285 Leu Ala Val Val Lys Arg Glu Pro Ala Glu Gln Pro Gly Asp Gly Glu 290 295 300 Arg Thr Asp Cys Glu Pro Val Gly Leu Glu Pro Ala Val Glu Gln Ser 305 310 315 320 Ser Ala Ala Ser Glu Leu Ala Glu Ala Ser Ser Glu Glu Leu Ala Glu 325 330 335 Ala Pro Thr Glu Ala Pro Ser Pro Glu Ala Arg Asp Ser Lys Glu Asp 340 345 350 Gly Arg Lys Phe Asp Phe Asp Ala Cys Asn Glu Val Pro Pro Ala Pro 355 360 365 Lys Glu Ser Ser Thr Ser Glu Gly Ala Asp Gln Lys Met Ser Ser Phe 370 375 380 Lys Glu Glu Lys Asp Ile Lys Pro Ile Ile Lys Asp Glu Lys Gly Arg 385 390 395 400 Val Gly Ser Gly Ser Gly Arg Asn Leu Trp Val Ser Gly Leu Ser Ser 405 410 415 Thr Thr Arg Ala Thr Asp Leu Lys Asn Leu Phe Ser Lys Tyr Gly Lys 420 425 430 Val Val Gly Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Arg 435 440 445 Cys Tyr Gly Phe Val Thr Met Ser Thr Ser Asp Glu Ala Thr Lys Cys 450 455 460 Ile Ser His Leu His Arg Thr Glu Leu His Gly Arg Met Ile Ser Val 465 470 475 480 Glu Lys Ala Lys Asn Glu Pro Ala Gly Lys Lys Leu Ser Asp Arg Lys 485 490 495 Glu Cys Glu Val Lys Lys Glu Lys Leu Ser Ser Val Asp Arg His His 500 505 510 Ser Val Glu Ile Lys Ile Glu Lys Thr Val Ile Lys Lys Glu Glu Lys 515 520 525 Ile Glu Lys Lys Glu Glu Lys Lys Pro Glu Asp Ile Lys Lys Glu Glu 530 535 540 Lys Asp Gln Asp Glu Leu Lys Pro Gly Pro Thr Asn Arg Ser Arg Val 545 550 555 560 Thr Lys Ser Gly Ser Arg Gly Met Glu Arg Thr Val Val Met Asp Lys 565 570 575 Ser Lys Gly Glu Pro Val Ile Ser Val Lys Thr Thr Ser Arg Ser Lys 580 585 590 Glu Arg Ser Ser Lys Ser Gln Asp Arg Lys Ser Glu Ser Lys Glu Lys 595 600 605 Arg Asp Ile Leu Ser Phe Asp Lys Ile Lys Glu Gln Arg Glu Arg Glu 610 615 620 Arg Gln Arg Gln Arg Glu Arg Glu Ile Arg Glu Thr Glu Arg Arg Arg 625 630 635 640 Glu Arg Glu Gln Arg Glu Arg Glu Gln Arg Leu Glu Ala Phe His Glu 645 650 655 Arg Lys Glu Lys Ala Arg Leu Gln Arg Glu Arg Leu Gln Leu Glu Cys 660 665 670 Gln Arg Gln Arg Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu 675 680 685 Arg Glu Arg Met Arg Val Glu Arg Glu Arg Arg Lys Glu Gln Glu Arg 690 695 700 Ile His Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Glu Gln Leu Arg 705 710 715 720 Tyr Glu Gln Glu Arg Arg Pro Gly Arg Arg Pro Tyr Asp Leu Asp Arg 725 730 735 Arg Asp Asp Ala Tyr Trp Pro Glu Gly Lys Arg Val Ala Met Glu Asp 740 745 750 Arg Tyr Arg Ala Asp Phe Pro Arg Pro Asp His Arg Phe His Asp Phe 755 760 765 Asp His Arg Asp Arg Gly Gln Tyr Gln Asp His Ala Ile Asp Arg Arg 770 775 780 Glu Gly Ser Arg Pro Met Met Gly Asp His Arg Asp Gly Gln His Tyr 785 790 795 800 Gly Asp Asp Arg His Gly His Gly Gly Pro Pro Glu Arg His Gly Arg 805 810 815 Asp Ser Arg Asp Gly Trp Gly Gly Tyr Gly Ser Asp Lys Arg Leu Ser 820 825 830 Glu Gly Arg Gly Leu Pro Pro Pro Pro Arg Gly Gly Arg Asp Trp Gly 835 840 845 Glu His Asn Gln Arg Leu Glu Glu His Gln Ala Arg Ala Trp Gln Gly 850 855 860 Ala Met Asp Ala Gly Ala Ala Ser Arg Glu His Ala Arg Trp Gln Gly 865 870 875 880 Gly Glu Arg Gly Leu Ser Gly Pro Ser Gly Pro Gly His Met Ala Ser 885 890 895 Arg Gly Gly Val Ala Gly Arg Gly Gly Phe Ala Gln Gly Gly His Ser 900 905 910 Gln Gly His Val Val Pro Gly Gly Gly Leu Glu Gly Gly Gly Val Ala 915 920 925 Ser Gln Asp Arg Gly Ser Arg Val Pro His Pro His Pro His Pro Pro 930 935 940 Pro Tyr Pro His Phe Thr Arg Arg Tyr 945 950 <210> SEQ ID NO 82 <211> LENGTH: 5858 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (900)..(900) <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid <400> SEQUENCE: 82 Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 1 5 10 15 Met Leu Val Val Pro Gln Ala Glu Cys Thr Gly Arg Ser Pro Tyr Asp 20 25 30 Ser Leu Ser Val Leu Asp Gly Thr Leu Pro Val Pro Asn Thr Gly Leu 35 40 45 Trp Gly Pro Thr Gly Ser Gln Cys Gln Glu Thr Gln Gly Leu Ala Trp 50 55 60 Met Gly Cys Pro Gly Glu Glu Thr Gln Gly Pro Val Glu Pro Ser Trp 65 70 75 80 Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser Pro 85 90 95 Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser Leu 100 105 110 Ser Arg Lys Gln Met Leu Pro Leu Pro Ala Gly Lys Gly Val Phe Ala 115 120 125 Ser Pro Lys Gly Gly Gly Pro Asp Leu Gly Val Gln Leu Pro Pro Ala 130 135 140 Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp Gly Asp Phe 145 150 155 160 His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro Gly Leu Cys 165 170 175 Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu Asp Phe Asn 180 185 190 Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val Val Thr Arg 195 200 205 Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser Asn Gly Ser 210 215 220 Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser Arg Thr Gly 225 230 235 240 Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser Ile Arg Leu 245 250 255 Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu Leu Glu Leu 260 265 270 Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly Asp Phe Asn 275 280 285 Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala Arg Leu Thr 290 295 300 Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln 305 310 315 320 Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Pro 325 330 335 Pro Trp Met Ala Gly Val Pro Ser Leu Ala His Cys Ala Pro Gln Glu 340 345 350 Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His 355 360 365 Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu 370 375 380

Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg 385 390 395 400 Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu 405 410 415 Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly 420 425 430 Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys 435 440 445 Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu 450 455 460 Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys 465 470 475 480 Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr 485 490 495 Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu 500 505 510 Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr 515 520 525 Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu 530 535 540 Ser Lys Ser His Ile Pro His Met Gly Ile Pro Ser Thr Leu Leu Gly 545 550 555 560 Gly Thr Pro His His Arg Ala Arg Pro Asn Ala Arg Val Gly Pro Ser 565 570 575 Pro Gln Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg 580 585 590 Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu 595 600 605 Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly 610 615 620 Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn 625 630 635 640 Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly 645 650 655 Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met Gln Val Phe 660 665 670 Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly 675 680 685 Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val 690 695 700 Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala 705 710 715 720 Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser 725 730 735 Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp 740 745 750 Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro 755 760 765 Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu 770 775 780 Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala 785 790 795 800 Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr 805 810 815 Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala 820 825 830 Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser 835 840 845 Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe 850 855 860 Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys Pro Cys Tyr 865 870 875 880 Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His Asp Glu Gly 885 890 895 Ala Val Trp Xaa Gly Ser Gly Gly Lys Ala Gly Pro Pro Gly Cys Ala 900 905 910 Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro 915 920 925 Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe 930 935 940 Ser Thr His Cys Val Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser 945 950 955 960 Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His 965 970 975 Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn 980 985 990 Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys 995 1000 1005 Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp 1010 1015 1020 Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln 1025 1030 1035 1040 Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr 1045 1050 1055 Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile 1060 1065 1070 Lys Leu Phe Val Glu Val Arg Thr Ala Pro Ala Val Ser Thr Pro Asp 1075 1080 1085 Pro Ala Ala Asn Glu Pro Ala Pro Arg Glu Ala Ser Val Gly Phe Arg 1090 1095 1100 Gln Arg Leu Pro Pro Leu Gln Ser Tyr Glu Leu Ile Leu Gln Glu Gly 1105 1110 1115 1120 Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro Pro Tyr Lys 1125 1130 1135 Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His Gly Met Ala 1140 1145 1150 Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu His Gln Asp 1155 1160 1165 Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp Asp Asn Ala 1170 1175 1180 Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly Asp Ala Leu 1185 1190 1195 1200 Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro Asp Ala Leu 1205 1210 1215 Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys Ser Trp Ala 1220 1225 1230 Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala Ala Cys Arg 1235 1240 1245 Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val Asn Asp Ala 1250 1255 1260 Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys Thr Ala Val 1265 1270 1275 1280 Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys Val Ser Trp 1285 1290 1295 Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr Asn Pro His 1300 1305 1310 Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro Cys Leu Lys 1315 1320 1325 Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu Pro Gly Leu 1330 1335 1340 Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe Phe Asn Glu 1345 1350 1355 1360 Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp Lys Asp Gly 1365 1370 1375 Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu Asn Cys Gln 1380 1385 1390 Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His Ser Leu Glu 1395 1400 1405 Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr Gln Asp Val 1410 1415 1420 Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile Ala Ile Cys 1425 1430 1435 1440 Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys Pro Gly Thr 1445 1450 1455 Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val Pro His Ser 1460 1465 1470 Thr Thr Ser Pro Ala Leu Pro Val Ser Thr Val Cys Val Arg Glu Val 1475 1480 1485 Cys Arg Trp Ser Ser Trp Tyr Asn Gly His Arg Pro Glu Pro Gly Leu 1490 1495 1500 Gly Gly Gly Asp Phe Glu Thr Phe Glu Asn Leu Arg Gln Arg Gly Tyr 1505 1510 1515 1520 Gln Val Cys Pro Val Leu Ala Asp Ile Glu Cys Arg Ala Ala Gln Leu 1525 1530 1535 Pro Asp Met Pro Leu Glu Glu Leu Gly Gln Gln Val Asp Cys Asp Arg 1540 1545 1550 Met Arg Gly Leu Met Cys Ala Asn Ser Gln Gln Ser Pro Pro Leu Cys 1555 1560 1565 His Asp Tyr Glu Leu Arg Val Leu Cys Cys Glu Tyr Val Pro Cys Gly 1570 1575 1580 Pro Ser Pro Ala Pro Gly Thr Ser Pro Gln Pro Ser Leu Ser Ala Ser 1585 1590 1595 1600 Thr Glu Pro Ala Val Pro Thr Pro Thr Gln Thr Thr Ala Thr Glu Lys 1605 1610 1615 Thr Thr Leu Trp Val Thr Pro Ser Ile Arg Ser Thr Ala Ala Leu Thr 1620 1625 1630 Ser Gln Thr Gly Ser Ser Ser Gly Pro Val Thr Val Thr Pro Ser Ala 1635 1640 1645 Pro Gly Thr Thr Thr Cys Gln Pro Arg Cys Gln Trp Thr Glu Trp Phe 1650 1655 1660 Asp Glu Asp Tyr Pro Lys Ser Glu Gln Leu Gly Gly Asp Val Glu Ser 1665 1670 1675 1680 Tyr Asp Lys Ile Arg Ala Ala Gly Gly His Leu Cys Gln Gln Pro Lys 1685 1690 1695 Asp Ile Glu Cys Gln Ala Glu Ser Phe Pro Asn Trp Thr Leu Ala Gln 1700 1705 1710 Val Gly Gln Lys Val His Cys Asp Val His Phe Gly Leu Val Cys Arg 1715 1720 1725

Asn Trp Glu Gln Glu Gly Val Phe Lys Met Cys Tyr Asn Tyr Arg Ile 1730 1735 1740 Arg Val Leu Cys Cys Ser Asp Asp His Cys Arg Gly Arg Ala Thr Thr 1745 1750 1755 1760 Pro Pro Pro Thr Thr Glu Leu Glu Thr Ala Thr Thr Thr Thr Thr Gln 1765 1770 1775 Ala Leu Phe Ser Thr Pro Gln Pro Thr Ser Ser Pro Gly Leu Thr Arg 1780 1785 1790 Ala Pro Pro Ala Ser Thr Thr Ala Val Pro Thr Leu Ser Glu Gly Leu 1795 1800 1805 Thr Ser Pro Arg Tyr Thr Ser Thr Leu Gly Thr Ala Thr Thr Gly Gly 1810 1815 1820 Pro Thr Thr Pro Ala Gly Ser Thr Glu Pro Thr Val Pro Gly Val Ala 1825 1830 1835 1840 Thr Ser Thr Leu Pro Thr Arg Ser Ala Leu Pro Gly Thr Thr Gly Ser 1845 1850 1855 Leu Gly Thr Trp Arg Pro Ser Gln Pro Pro Thr Leu Ala Pro Thr Thr 1860 1865 1870 Met Ala Thr Ser Arg Ala Arg Pro Thr Gly Thr Ala Ser Thr Ala Ser 1875 1880 1885 Lys Glu Pro Leu Thr Thr Ser Leu Ala Pro Thr Leu Thr Ser Glu Leu 1890 1895 1900 Ser Thr Ser Gln Ala Glu Thr Ser Thr Pro Arg Thr Glu Thr Thr Met 1905 1910 1915 1920 Ser Pro Leu Thr Asn Thr Thr Thr Ser Gln Gly Thr Thr Arg Cys Gln 1925 1930 1935 Pro Lys Cys Glu Trp Thr Glu Trp Phe Asp Val Asp Phe Pro Thr Ser 1940 1945 1950 Gly Val Ala Gly Gly Asp Met Glu Thr Phe Glu Asn Ile Arg Ala Ala 1955 1960 1965 Gly Gly Lys Met Cys Trp Ala Pro Lys Ser Ile Glu Cys Arg Ala Glu 1970 1975 1980 Asn Tyr Pro Glu Val Ser Ile Asp Gln Val Gly Gln Val Leu Thr Cys 1985 1990 1995 2000 Ser Leu Glu Thr Gly Leu Thr Cys Lys Asn Glu Asp Gln Thr Gly Arg 2005 2010 2015 Phe Asn Met Cys Phe Asn Tyr Asn Val Arg Val Leu Cys Cys Asp Asp 2020 2025 2030 Tyr Ser His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro 2035 2040 2045 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Pro Thr Thr Thr 2050 2055 2060 Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Thr Ser Thr 2065 2070 2075 2080 Leu Arg Thr Ala Pro Pro Pro Lys Val Leu Thr Thr Thr Ala Thr Thr 2085 2090 2095 Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr 2100 2105 2110 Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala 2115 2120 2125 Thr Ser Val Thr Pro Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr 2130 2135 2140 Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr 2145 2150 2155 2160 Pro Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Ala 2165 2170 2175 Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser 2180 2185 2190 Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr 2195 2200 2205 Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro 2210 2215 2220 Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr 2225 2230 2235 2240 Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Thr Val Leu 2245 2250 2255 Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser 2260 2265 2270 Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala 2275 2280 2285 Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro 2290 2295 2300 Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro 2305 2310 2315 2320 Ala Ala Thr Ser Asn Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr 2325 2330 2335 His Thr Pro Pro Val Pro Asn Thr Met Ala Thr Thr His Gly Arg Ser 2340 2345 2350 Leu Pro Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala 2355 2360 2365 Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Val 2370 2375 2380 Thr Ser His Thr Leu Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr 2385 2390 2395 2400 Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro 2405 2410 2415 Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg 2420 2425 2430 Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu 2435 2440 2445 Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly 2450 2455 2460 Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro 2465 2470 2475 2480 Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg 2485 2490 2495 Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg 2500 2505 2510 Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val 2515 2520 2525 Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val 2530 2535 2540 Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys 2545 2550 2555 2560 Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met 2565 2570 2575 Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr 2580 2585 2590 Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser 2595 2600 2605 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr 2610 2615 2620 Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala 2625 2630 2635 2640 Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val 2645 2650 2655 Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala 2660 2665 2670 Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe 2675 2680 2685 Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser 2690 2695 2700 Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser 2705 2710 2715 2720 Thr Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr 2725 2730 2735 Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly 2740 2745 2750 Thr Ala His Thr Thr Lys Val Leu Thr Thr Thr Thr Thr Gly Phe Thr 2755 2760 2765 Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Leu Pro Val Trp 2770 2775 2780 Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro 2785 2790 2795 2800 Ser Ser Ile Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr 2805 2810 2815 Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr 2820 2825 2830 Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile 2835 2840 2845 Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr 2850 2855 2860 Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr 2865 2870 2875 2880 Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro 2885 2890 2895 Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro 2900 2905 2910 Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly 2915 2920 2925 Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His 2930 2935 2940 Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu 2945 2950 2955 2960 Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro 2965 2970 2975 Gly Thr Thr Thr Pro Gly His Thr Arg Ala Thr Ser Arg Thr Thr Ala 2980 2985 2990 Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser 2995 3000 3005 Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro 3010 3015 3020 Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly 3025 3030 3035 3040 Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly 3045 3050 3055 Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala

3060 3065 3070 Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser 3075 3080 3085 Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe 3090 3095 3100 Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly 3105 3110 3115 3120 His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser 3125 3130 3135 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Gln Thr Thr Ala Ala Thr 3140 3145 3150 Thr Thr Ala Thr Thr Gly Ser Thr Ala Ile Pro Ser Ser Thr Pro Gly 3155 3160 3165 Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr 3170 3175 3180 Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr 3185 3190 3195 3200 Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser 3205 3210 3215 Phe Thr Pro Ile Pro Ser Phe Thr Leu Gly Thr Thr Gly Thr Leu Pro 3220 3225 3230 Glu Gln Thr Thr Thr Pro Met Ala Thr Met Ser Thr Ile His Pro Ser 3235 3240 3245 Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys Ala 3250 3255 3260 Thr Thr Thr Arg Ala Thr Ser Ser Met Ser Thr Pro Ser Ser Thr Pro 3265 3270 3275 3280 Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr Thr 3285 3290 3295 Ala Ala Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr 3300 3305 3310 Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr 3315 3320 3325 Gly Ser Thr Ala Thr Ala Ser Ser Thr Arg Ala Thr Ala Gly Thr Leu 3330 3335 3340 Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr Val Ile Ser Ser Arg 3345 3350 3355 3360 Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu 3365 3370 3375 Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr Ala Ile Pro 3380 3385 3390 Ser Ser Ser Leu Gly Thr Ala Trp Thr Arg Leu Ser Gln Thr Thr Thr 3395 3400 3405 Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr 3410 3415 3420 Val His Thr Ser Thr Val Leu Thr Thr Thr Thr Thr Thr Thr Arg Ala 3425 3430 3435 3440 Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr 3445 3450 3455 Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser 3460 3465 3470 Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr 3475 3480 3485 Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro 3490 3495 3500 Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr Thr Val 3505 3510 3515 3520 Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly 3525 3530 3535 Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly 3540 3545 3550 Arg Ser Leu Pro Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr 3555 3560 3565 Ser Ala Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser 3570 3575 3580 Thr Val Thr Ser His Thr Pro Ala Ala Thr Thr Ser Thr Thr Gln His 3585 3590 3595 3600 Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu 3605 3610 3615 Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Arg Gly Thr 3620 3625 3630 Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr 3635 3640 3645 Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr 3650 3655 3660 Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser 3665 3670 3675 3680 Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn 3685 3690 3695 Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu 3700 3705 3710 Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln 3715 3720 3725 Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu 3730 3735 3740 Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe 3745 3750 3755 3760 Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr 3765 3770 3775 Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Leu 3780 3785 3790 Thr Thr Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro 3795 3800 3805 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr 3810 3815 3820 Ala Thr Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr 3825 3830 3835 3840 Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro 3845 3850 3855 Thr Val Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala 3860 3865 3870 Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr 3875 3880 3885 Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg 3890 3895 3900 Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro 3905 3910 3915 3920 Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Thr Thr 3925 3930 3935 Ala Thr Thr Thr Arg Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr 3940 3945 3950 Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly 3955 3960 3965 Phe Thr Val Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Pro Pro 3970 3975 3980 Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val 3985 3990 3995 4000 Thr Pro Ser Ser Val Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr 4005 4010 4015 Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser 4020 4025 4030 Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Ile Thr Thr Ala Thr 4035 4040 4045 Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly 4050 4055 4060 Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala 4065 4070 4075 4080 Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His 4085 4090 4095 Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu 4100 4105 4110 Ser Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr 4115 4120 4125 Ser Gly Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr 4130 4135 4140 Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro 4145 4150 4155 4160 Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro 4165 4170 4175 Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr 4180 4185 4190 Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro 4195 4200 4205 Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Thr Gly Cys 4210 4215 4220 Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met 4225 4230 4235 4240 Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala 4245 4250 4255 Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala 4260 4265 4270 Gln Ala Gln Pro Gly Val Pro Leu Gly Glu Leu Gly Gln Val Val Glu 4275 4280 4285 Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly 4290 4295 4300 Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn 4305 4310 4315 4320 Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met Pro 4325 4330 4335 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr 4340 4345 4350 Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr 4355 4360 4365 Pro Gly Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Pro Ala Thr Thr 4370 4375 4380 Pro Thr Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr 4385 4390 4395 4400

Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala 4405 4410 4415 Thr Ser Val Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr 4420 4425 4430 Leu Pro Glu Gln Thr Thr Thr Pro Val Ala Thr Met Ser Thr Ile His 4435 4440 4445 Pro Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr 4450 4455 4460 Lys Ala Thr Thr Thr Arg Ala Thr Ser Ser Thr Ser Thr Pro Ser Ser 4465 4470 4475 4480 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr 4485 4490 4495 Thr Thr Ala Ala Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly 4500 4505 4510 Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala 4515 4520 4525 Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp 4530 4535 4540 Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr Gly 4545 4550 4555 4560 Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr Pro His 4565 4570 4575 Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr 4580 4585 4590 Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser 4595 4600 4605 Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser 4610 4615 4620 Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr 4625 4630 4635 4640 Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His 4645 4650 4655 Thr Ser Thr Val Leu Thr Ala Thr Ala Thr Thr Thr Gly Ala Thr Gly 4660 4665 4670 Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys 4675 4680 4685 Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser 4690 4695 4700 Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr 4705 4710 4715 4720 Pro Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser 4725 4730 4735 Ser Ile Pro Gly Thr Thr His Thr Ala Arg Val Leu Thr Thr Thr Thr 4740 4745 4750 Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln 4755 4760 4765 Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr 4770 4775 4780 Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro 4785 4790 4795 4800 Ile Thr Pro Val Leu Thr Ser Thr Ala Thr Thr Pro Ala Ala Thr Ser 4805 4810 4815 Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro 4820 4825 4830 Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro 4835 4840 4845 Ile Pro Ser Ser Thr Leu Trp Thr Thr Trp Thr Val Pro Ala Gln Thr 4850 4855 4860 Thr Thr Pro Met Ser Thr Met Ser Thr Ile His Thr Ser Ser Thr Pro 4865 4870 4875 4880 Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Met Thr 4885 4890 4895 Arg Ala Thr Asn Ser Thr Ala Thr Pro Ser Ser Thr Leu Gly Thr Thr 4900 4905 4910 Arg Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ala Thr 4915 4920 4925 Gly Ser Thr Ala Thr Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu 4930 4935 4940 Thr Glu Pro Ser Thr Ile Ala Thr Val Met Val Pro Thr Gly Ser Thr 4945 4950 4955 4960 Ala Thr Ala Ser Ser Thr Leu Gly Thr Ala His Thr Pro Lys Val Val 4965 4970 4975 Thr Thr Met Ala Thr Met Pro Thr Ala Thr Ala Ser Thr Val Pro Ser 4980 4985 4990 Ser Ser Thr Val Gly Thr Thr Arg Thr Pro Ala Val Leu Pro Ser Ser 4995 5000 5005 Leu Pro Thr Phe Ser Val Ser Thr Val Ser Ser Ser Val Leu Thr Thr 5010 5015 5020 Leu Arg Pro Thr Gly Phe Pro Ser Ser His Phe Ser Thr Pro Cys Phe 5025 5030 5035 5040 Cys Arg Ala Phe Gly Gln Phe Phe Ser Pro Gly Glu Val Ile Tyr Asn 5045 5050 5055 Lys Thr Asp Arg Ala Gly Cys His Phe Tyr Ala Val Cys Asn Gln His 5060 5065 5070 Cys Asp Ile Asp Arg Phe Gln Gly Ala Cys Pro Thr Ser Pro Pro Pro 5075 5080 5085 Val Ser Ser Ala Pro Leu Ser Ser Pro Ser Pro Ala Pro Gly Cys Asp 5090 5095 5100 Asn Ala Ile Pro Leu Arg Gln Val Asn Glu Thr Trp Thr Leu Glu Asn 5105 5110 5115 5120 Cys Thr Val Ala Arg Cys Val Gly Asp Asn Arg Val Val Leu Leu Asp 5125 5130 5135 Pro Lys Pro Val Ala Asn Val Thr Cys Val Asn Lys His Leu Pro Ile 5140 5145 5150 Lys Val Ser Asp Pro Ser Gln Pro Cys Asp Phe His Tyr Glu Cys Glu 5155 5160 5165 Cys Ile Cys Ser Met Trp Gly Gly Ser His Tyr Ser Thr Phe Asp Gly 5170 5175 5180 Thr Ser Tyr Thr Phe Arg Gly Asn Cys Thr Tyr Val Leu Met Arg Glu 5185 5190 5195 5200 Ile His Ala Arg Phe Gly Asn Leu Ser Leu Tyr Leu Asp Asn His Tyr 5205 5210 5215 Cys Thr Ala Ser Ala Thr Ala Ala Ala Ala Arg Cys Pro Arg Ala Leu 5220 5225 5230 Ser Ile His Tyr Lys Ser Met Asp Ile Val Leu Thr Val Thr Met Val 5235 5240 5245 His Gly Lys Glu Glu Gly Leu Ile Leu Phe Asp Gln Ile Pro Val Ser 5250 5255 5260 Ser Gly Phe Ser Lys Asn Gly Val Leu Val Ser Val Leu Gly Thr Thr 5265 5270 5275 5280 Thr Met Arg Val Asp Ile Pro Ala Leu Gly Val Ser Val Thr Phe Asn 5285 5290 5295 Gly Gln Val Phe Gln Ala Arg Leu Pro Tyr Ser Leu Phe His Asn Asn 5300 5305 5310 Thr Glu Gly Gln Cys Gly Thr Cys Thr Asn Asn Gln Arg Asp Asp Cys 5315 5320 5325 Leu Gln Arg Asp Gly Thr Thr Ala Ala Ser Cys Lys Asp Met Ala Lys 5330 5335 5340 Thr Trp Leu Val Pro Asp Ser Arg Lys Asp Gly Cys Trp Ala Pro Thr 5345 5350 5355 5360 Gly Thr Pro Pro Thr Ala Ser Pro Ala Ala Pro Val Ser Ser Thr Pro 5365 5370 5375 Thr Pro Thr Pro Cys Pro Pro Gln Pro Leu Cys Asp Leu Met Leu Ser 5380 5385 5390 Gln Val Phe Ala Glu Cys His Asn Leu Val Pro Pro Gly Pro Phe Phe 5395 5400 5405 Asn Ala Cys Ile Ser Asp His Cys Arg Gly Arg Leu Glu Val Pro Cys 5410 5415 5420 Gln Ser Leu Glu Ala Tyr Ala Glu Leu Cys Arg Ala Arg Gly Val Cys 5425 5430 5435 5440 Ser Asp Trp Arg Gly Ala Thr Gly Gly Leu Cys Asp Leu Thr Cys Pro 5445 5450 5455 Pro Thr Lys Val Tyr Lys Pro Cys Gly Pro Ile Gln Pro Ala Thr Cys 5460 5465 5470 Asn Ser Arg Asn Gln Ser Pro Gln Leu Glu Gly Met Ala Glu Gly Cys 5475 5480 5485 Phe Cys Pro Glu Asp Gln Ile Leu Phe Asn Ala His Met Gly Ile Cys 5490 5495 5500 Val Gln Ala Cys Pro Cys Val Gly Pro Asp Gly Phe Pro Lys Phe Pro 5505 5510 5515 5520 Gly Glu Arg Trp Val Ser Asn Cys Gln Ser Cys Val Cys Asp Glu Gly 5525 5530 5535 Ser Val Ser Val Gln Cys Lys Pro Leu Pro Cys Asp Ala Gln Gly Gln 5540 5545 5550 Pro Pro Pro Cys Asn Arg Pro Gly Phe Val Thr Val Thr Arg Pro Arg 5555 5560 5565 Ala Glu Asn Pro Cys Cys Pro Glu Thr Val Cys Val Cys Asn Thr Thr 5570 5575 5580 Thr Cys Pro Gln Ser Leu Pro Val Cys Pro Pro Gly Gln Glu Ser Ile 5585 5590 5595 5600 Cys Thr Gln Glu Glu Gly Asp Cys Cys Pro Thr Phe Arg Cys Arg Pro 5605 5610 5615 Gln Leu Cys Ser Tyr Asn Gly Thr Phe Tyr Gly Val Gly Ala Thr Phe 5620 5625 5630 Pro Gly Ala Leu Pro Cys His Met Cys Thr Cys Leu Ser Gly Asp Thr 5635 5640 5645 Gln Asp Pro Thr Val Gln Cys Gln Glu Asp Ala Cys Asn Asn Thr Thr 5650 5655 5660 Cys Pro Gln Gly Phe Glu Tyr Lys Arg Val Ala Gly Gln Cys Cys Gly 5665 5670 5675 5680 Glu Cys Val Gln Thr Ala Cys Leu Thr Pro Asp Gly Gln Pro Val Gln 5685 5690 5695 Leu Asn Glu Thr Trp Val Asn Ser His Val Asp Asn Cys Thr Val Tyr 5700 5705 5710 Leu Cys Glu Ala Glu Gly Gly Val His Leu Leu Thr Pro Gln Pro Ala 5715 5720 5725 Ser Cys Pro Asp Val Ser Ser Cys Arg Gly Ser Leu Arg Lys Thr Gly 5730 5735 5740

Cys Cys Tyr Ser Cys Glu Glu Asp Ser Cys Gln Val Arg Ile Asn Thr 5745 5750 5755 5760 Thr Ile Leu Trp His Gln Gly Cys Glu Thr Glu Val Asn Ile Thr Phe 5765 5770 5775 Cys Glu Gly Ser Cys Pro Gly Ala Ser Lys Tyr Ser Ala Glu Ala Gln 5780 5785 5790 Ala Met Gln His Gln Cys Thr Cys Cys Gln Glu Arg Arg Val His Glu 5795 5800 5805 Glu Thr Val Pro Leu His Cys Pro Asn Gly Ser Ala Ile Leu His Thr 5810 5815 5820 Tyr Thr His Val Asp Glu Cys Gly Cys Thr Pro Phe Cys Val Pro Ala 5825 5830 5835 5840 Pro Met Ala Pro Pro His Thr Arg Gly Phe Pro Ala Gln Glu Ala Thr 5845 5850 5855 Ala Val <210> SEQ ID NO 83 <211> LENGTH: 619 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 83 Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 1 5 10 15 Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 20 25 30 Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 35 40 45 Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 50 55 60 Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 65 70 75 80 Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 85 90 95 Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 100 105 110 Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile Phe Ser Ser Pro 115 120 125 Glu Asp Asp Met Val Val Ala Pro Val Thr His Val Ser Val Thr Leu 130 135 140 Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val Gln Glu Lys Tyr 145 150 155 160 Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro Lys Arg Lys Lys 165 170 175 Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro Ala Thr Thr Pro 180 185 190 Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys Gly Asn Thr Ile 195 200 205 Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Lys Ala Thr Cys 210 215 220 Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys Leu 225 230 235 240 Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys His Lys Asn Lys 245 250 255 Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr Tyr 260 265 270 Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr Gln 275 280 285 Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn Asp Glu Asp Pro 290 295 300 Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser Ser Ser Ala Thr 305 310 315 320 Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser Ser Ser Pro Gly 325 330 335 Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly Asn Ser Lys Ala 340 345 350 Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro Ser Glu Val Leu 355 360 365 Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr Gln Leu Phe Arg 370 375 380 Thr Val His Val Val Gln Pro Val Gln Ala Val Pro Glu Gly Glu Ala 385 390 395 400 Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn Ser Ser Val Gln 405 410 415 Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro Val Val Val Ser 420 425 430 Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln Thr Val Pro Leu 435 440 445 Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly Thr Gly Ser Gln 450 455 460 Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro Met Thr Val Leu 465 470 475 480 Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly Ser Pro Pro Ser 485 490 495 Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu Thr Ser Asn Val 500 505 510 Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser Ser Pro Ser Phe 515 520 525 Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg Ser Ser Gln Leu 530 535 540 Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val Ile Lys Thr Gln 545 550 555 560 Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys Glu Ser Glu Asp 565 570 575 His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln Pro Gln Pro Tyr 580 585 590 Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser Gln Val Ala Met 595 600 605 Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe 610 615 <210> SEQ ID NO 84 <211> LENGTH: 753 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 84 Met Gly Glu His Ser Pro Asp Asn Asn Ile Ile Tyr Phe Glu Ala Glu 1 5 10 15 Glu Asp Glu Leu Thr Pro Asp Asp Lys Met Leu Arg Phe Val Asp Lys 20 25 30 Asn Gly Leu Val Pro Ser Ser Ser Gly Thr Val Tyr Asp Arg Thr Thr 35 40 45 Val Leu Ile Glu Gln Asp Pro Gly Thr Leu Glu Asp Glu Asp Asp Asp 50 55 60 Gly Gln Cys Gly Glu His Leu Pro Phe Leu Val Gly Gly Glu Glu Gly 65 70 75 80 Phe His Leu Ile Asp His Glu Ala Met Ser Gln Gly Tyr Val Gln His 85 90 95 Ile Ile Ser Pro Asp Gln Ile His Leu Thr Ile Asn Pro Gly Ser Thr 100 105 110 Pro Met Pro Arg Asn Ile Glu Gly Ala Thr Leu Thr Leu Gln Ser Glu 115 120 125 Cys Pro Glu Thr Lys Arg Lys Glu Val Lys Arg Tyr Gln Cys Thr Phe 130 135 140 Glu Gly Cys Pro Arg Thr Tyr Ser Thr Ala Gly Asn Leu Arg Thr His 145 150 155 160 Gln Lys Thr His Arg Gly Glu Tyr Thr Phe Val Cys Asn Gln Glu Gly 165 170 175 Cys Gly Lys Ala Phe Leu Thr Ser His Ser Leu Arg Ile His Val Arg 180 185 190 Val His Thr Lys Glu Lys Pro Phe Glu Cys Asp Val Gln Gly Cys Glu 195 200 205 Lys Ala Phe Asn Thr Leu Tyr Arg Leu Lys Ala His Gln Arg Leu His 210 215 220 Thr Gly Lys Thr Phe Asn Cys Glu Ser Glu Gly Cys Ser Lys Tyr Phe 225 230 235 240 Thr Thr Leu Ser Asp Leu Arg Lys His Ile Arg Thr His Thr Gly Glu 245 250 255 Lys Pro Phe Arg Cys Asp His Asp Gly Cys Gly Lys Ala Phe Ala Ala 260 265 270 Ser His His Leu Lys Thr His Val Arg Thr His Thr Gly Glu Arg Pro 275 280 285 Phe Phe Cys Pro Ser Asn Gly Cys Glu Lys Thr Phe Ser Thr Gln Tyr 290 295 300 Ser Leu Lys Ser His Met Lys Gly His Asp Asn Lys Gly His Ser Tyr 305 310 315 320 Asn Ala Leu Pro Gln His Asn Gly Ser Glu Asp Thr Asn His Ser Leu 325 330 335 Cys Leu Ser Asp Leu Ser Leu Leu Ser Thr Asp Ser Glu Leu Arg Glu 340 345 350 Asn Ser Ser Thr Thr Gln Gly Gln Asp Leu Ser Thr Ile Ser Pro Ala 355 360 365 Ile Ile Phe Glu Ser Met Phe Gln Asn Ser Asp Asp Thr Ala Ile Gln 370 375 380 Glu Asp Pro Gln Gln Thr Ala Ser Leu Thr Glu Ser Phe Asn Gly Asp 385 390 395 400 Ala Glu Ser Val Ser Asp Val Pro Pro Ser Thr Gly Asn Ser Ala Ser 405 410 415 Leu Ser Leu Pro Leu Val Leu Gln Pro Gly Leu Ser Glu Pro Pro Gln 420 425 430 Pro Leu Leu Pro Ala Ser Ala Pro Ser Ala Pro Pro Pro Ala Pro Ser 435 440 445 Leu Gly Pro Gly Ser Gln Gln Ala Ala Phe Gly Asn Pro Pro Ala Leu 450 455 460 Leu Gln Pro Pro Glu Val Pro Val Pro His Ser Thr Gln Phe Ala Ala 465 470 475 480 Asn His Gln Glu Phe Leu Pro His Pro Gln Ala Pro Gln Pro Ile Val 485 490 495 Pro Gly Leu Ser Val Val Ala Gly Ala Ser Ala Ser Ala Ala Ala Val

500 505 510 Ala Ser Ala Val Ala Ala Pro Ala Pro Pro Gln Ser Thr Thr Glu Pro 515 520 525 Leu Pro Ala Met Val Gln Thr Leu Pro Leu Gly Ala Asn Ser Val Leu 530 535 540 Thr Asn Asn Pro Thr Ile Thr Ile Thr Pro Thr Pro Asn Thr Ala Ile 545 550 555 560 Leu Gln Ser Ser Leu Val Met Gly Glu Gln Asn Leu Gln Trp Ile Leu 565 570 575 Asn Gly Ala Thr Ser Ser Pro Gln Asn Gln Glu Gln Ile Gln Gln Ala 580 585 590 Ser Lys Val Glu Lys Val Phe Phe Thr Thr Ala Val Pro Val Ala Ser 595 600 605 Ser Pro Gly Ser Ser Val Gln Gln Ile Gly Leu Ser Val Pro Val Ile 610 615 620 Ile Ile Lys Gln Glu Glu Ala Cys Gln Cys Gln Cys Ala Cys Arg Asp 625 630 635 640 Ser Ala Lys Glu Arg Ala Ser Ser Arg Arg Lys Gly Cys Ser Ser Pro 645 650 655 Pro Pro Pro Glu Pro Ser Pro Gln Ala Pro Asp Gly Pro Ser Leu Gln 660 665 670 Leu Pro Ala Gln Thr Phe Ser Ser Ala Pro Val Pro Gly Ser Ser Ser 675 680 685 Ser Thr Leu Pro Ser Ser Cys Glu Gln Ser Arg Gln Ala Glu Thr Pro 690 695 700 Ser Asp Pro Gln Thr Glu Thr Leu Ser Ala Met Asp Val Ser Glu Phe 705 710 715 720 Leu Ser Leu Gln Ser Leu Asp Thr Pro Ser Asn Leu Ile Pro Ile Glu 725 730 735 Ala Leu Leu Gln Gly Glu Glu Glu Met Gly Leu Thr Ser Ser Phe Ser 740 745 750 Lys <210> SEQ ID NO 85 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 85 Met Leu Cys Ala His Phe Ser Asp Gln Gly Pro Ala His Leu Thr Thr 1 5 10 15 Ser Lys Ser Ala Phe Leu Ser Asn Lys Lys Thr Ser Thr Leu Lys His 20 25 30 Leu Leu Gly Glu Thr Arg Ser Asp Gly Ser Ala Cys Asn Ser Gly Ile 35 40 45 Ser Gly Gly Arg Gly Arg Lys Ile Pro 50 55 <210> SEQ ID NO 86 <211> LENGTH: 726 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 1 5 10 15 Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 20 25 30 Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 35 40 45 Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 50 55 60 Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 65 70 75 80 Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 85 90 95 Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 100 105 110 His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 115 120 125 Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 130 135 140 Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 145 150 155 160 Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 165 170 175 Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 180 185 190 Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 195 200 205 Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 210 215 220 Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 225 230 235 240 Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 245 250 255 Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 260 265 270 Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 275 280 285 Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 290 295 300 Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 305 310 315 320 Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 325 330 335 Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 340 345 350 Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 355 360 365 Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 370 375 380 Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 385 390 395 400 Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 405 410 415 Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 420 425 430 Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 435 440 445 Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 450 455 460 Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 465 470 475 480 Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 485 490 495 Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 500 505 510 His Pro Ser Asn His His His His His Asn His His Ser His Lys His 515 520 525 Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 530 535 540 Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 545 550 555 560 Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 565 570 575 Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 580 585 590 Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 595 600 605 Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 610 615 620 Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 625 630 635 640 Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 645 650 655 Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 660 665 670 Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 675 680 685 Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 690 695 700 Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 705 710 715 720 Leu Pro Pro Leu Pro Lys 725 <210> SEQ ID NO 87 <211> LENGTH: 591 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 87 Met Tyr Leu Lys Asp Tyr Glu Arg Lys Val Ile Leu Glu Lys Ala Gly 1 5 10 15 Lys Tyr Val Asp Glu Glu Asn Ser Asp Gly Glu Thr Ser Asn His Arg 20 25 30 Leu Gln Glu Thr Ser Ser Gln Ser Tyr Val Glu Glu Gln Lys Gln Leu 35 40 45 Lys Glu Ser Phe Arg Ala Phe Val Glu Asp Ser Glu Asp Glu Asp Gly 50 55 60 Ala Gly Glu Gly Gly Ser Ser Leu Leu Gln Lys Arg Ala Lys Thr Arg 65 70 75 80 Gln Glu Lys Ala Gln Glu Glu Ala Asp Tyr Ile Glu Trp Leu Lys Gly 85 90 95 Gln Lys Glu Ile Arg Asn Pro Asp Ser Leu Lys Glu Leu Thr His Leu 100 105 110 Lys Glu Tyr Trp Asn Asp Pro Glu Leu Asp Glu Gly Glu Arg Phe Leu 115 120 125 Arg Asp Tyr Ile Leu Asn Lys Arg Tyr Glu Glu Glu Glu Glu Glu Glu 130 135 140 Glu Asp Glu Glu Glu Met Glu Glu Glu Lys Gly Val His Gly Pro Pro 145 150 155 160

Val Gln Leu Ala Val Asp Asp Ser Ser Asp Glu Gly Glu Leu Phe Leu 165 170 175 Lys Lys Gln Glu Asp Phe Glu Gln Lys Tyr Asn Phe Arg Phe Glu Glu 180 185 190 Pro Asp Ser Ala Ser Val Lys Thr Tyr Pro Arg Ser Ile Ala Ser Ser 195 200 205 Val Arg Arg Lys Asp Glu Arg Arg Lys Glu Lys Arg Glu Glu Thr Arg 210 215 220 Glu Arg Lys Lys Arg Glu Lys Ala Lys Lys Gln Glu Glu Leu Lys Gln 225 230 235 240 Leu Lys Asn Leu Lys Arg Lys Glu Ile Leu Ala Lys Leu Glu Lys Leu 245 250 255 Arg Lys Val Thr Gly Asn Glu Met Leu Gly Leu Glu Glu Gly Asp Leu 260 265 270 Glu Asp Asp Phe Asp Pro Ala Gln His Asp Gln Leu Met Gln Lys Cys 275 280 285 Phe Gly Asp Glu Tyr Tyr Gly Ala Val Glu Glu Glu Lys Pro Gln Phe 290 295 300 Glu Glu Glu Glu Gly Leu Glu Asp Asp Trp Asn Trp Asp Thr Trp Asp 305 310 315 320 Gly Pro Glu Gln Glu Gly Asp Trp Ser Gln Gln Glu Leu His Cys Glu 325 330 335 Asp Pro Asn Phe Asn Met Asp Ala Asp Tyr Asp Pro Ser Gln Pro Arg 340 345 350 Lys Lys Lys Arg Glu Ala Pro Leu Thr Gly Lys Lys Lys Arg Lys Ser 355 360 365 Pro Phe Ala Ala Ala Val Gly Gln Glu Lys Pro Val Phe Glu Pro Gly 370 375 380 Asp Lys Thr Phe Glu Glu Tyr Leu Asp Glu Tyr Tyr Arg Leu Asp Tyr 385 390 395 400 Glu Asp Ile Ile Asp Asp Leu Pro Cys Arg Phe Lys Tyr Arg Thr Val 405 410 415 Val Pro Cys Asp Phe Gly Leu Ser Thr Glu Glu Ile Leu Ala Ala Asp 420 425 430 Asp Lys Glu Leu Asn Arg Trp Cys Ser Leu Lys Lys Thr Cys Met Tyr 435 440 445 Arg Ser Glu Gln Glu Glu Leu Arg Asp Lys Arg Ala Tyr Ser Gln Lys 450 455 460 Ala Gln Asn Ser Trp Lys Lys Arg Gln Val Phe Lys Ser Leu Cys Arg 465 470 475 480 Glu Glu Ala Glu Thr Pro Ala Glu Ala Thr Gly Lys Pro Gln Arg Asp 485 490 495 Glu Ala Gly Pro Gln Arg Gln Leu Pro Ala Leu Asp Gly Ser Leu Met 500 505 510 Gly Pro Glu Ser Pro Pro Ala Gln Glu Glu Glu Ala Pro Val Ser Pro 515 520 525 His Lys Lys Pro Ala Pro Gln Lys Arg Arg Arg Ala Lys Lys Ala Arg 530 535 540 Leu Leu Gly Pro Thr Val Met Leu Gly Gly Cys Glu Phe Ser Arg Gln 545 550 555 560 Arg Leu Gln Ala Phe Gly Leu Asn Pro Lys Arg Leu His Phe Arg Gln 565 570 575 Leu Gly Arg Gln Arg Arg Lys Gln Gln Gly Pro Lys Asn Ser Ser 580 585 590 <210> SEQ ID NO 88 <211> LENGTH: 709 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Met Gly His Arg Thr Ala Met Pro Glu Pro Arg Gly Ser Ser Gln Leu 1 5 10 15 Arg Val Asn Ala Ala Phe Ala Ala Arg Tyr Asn Arg Tyr Arg Glu Arg 20 25 30 Glu Glu Leu Gln Arg Leu Lys Asp Arg Tyr Gly Asp Arg Asp Ser Ser 35 40 45 Ser Asp Ser Ser Ser Glu Ser Asp Ser Ser Asp Glu Arg Val Glu Phe 50 55 60 Asp Pro Gln Gln Glu Arg Asp Phe Tyr Lys Thr Leu Ser Leu Leu Lys 65 70 75 80 Lys Lys Asp Pro Arg Ile Tyr Gln Lys Asp Ala Thr Phe Tyr Asn Arg 85 90 95 Thr Ala Ser Ser Ser Asp Ser Glu Glu Asp Pro Glu Ala Leu Glu Lys 100 105 110 Gln Lys Lys Val Arg Pro Met Tyr Leu Lys Asp Tyr Glu Arg Lys Val 115 120 125 Ile Leu Glu Lys Ala Gly Lys Tyr Val Asp Glu Glu Asn Ser Asp Gly 130 135 140 Glu Thr Ser Asn His Arg Leu Gln Glu Thr Ser Ser Gln Ser Tyr Val 145 150 155 160 Glu Glu Gln Lys Gln Leu Lys Glu Ser Phe Arg Ala Phe Val Glu Asp 165 170 175 Ser Glu Asp Glu Asp Gly Ala Gly Glu Gly Gly Ser Ser Leu Leu Gln 180 185 190 Lys Arg Ala Lys Thr Arg Gln Glu Lys Ala Gln Glu Glu Ala Asp Tyr 195 200 205 Ile Glu Trp Leu Lys Gly Gln Lys Glu Ile Arg Asn Pro Asp Ser Leu 210 215 220 Lys Glu Leu Thr His Leu Lys Glu Tyr Trp Asn Asp Pro Glu Leu Asp 225 230 235 240 Glu Gly Glu Arg Phe Leu Arg Asp Tyr Ile Leu Asn Lys Arg Tyr Glu 245 250 255 Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Met Glu Glu Glu Lys 260 265 270 Gly Val His Gly Pro Pro Val Gln Leu Ala Val Asp Asp Ser Ser Asp 275 280 285 Glu Gly Glu Leu Phe Leu Lys Lys Gln Glu Asp Phe Glu Gln Lys Tyr 290 295 300 Asn Phe Arg Phe Glu Glu Pro Asp Ser Ala Ser Val Lys Thr Tyr Pro 305 310 315 320 Arg Ser Ile Ala Ser Ser Val Arg Arg Lys Asp Glu Arg Arg Lys Glu 325 330 335 Lys Arg Glu Glu Thr Arg Glu Arg Lys Lys Arg Glu Lys Ala Lys Lys 340 345 350 Gln Glu Glu Leu Lys Gln Leu Lys Asn Leu Lys Arg Lys Glu Ile Leu 355 360 365 Ala Lys Leu Glu Lys Leu Arg Lys Val Thr Gly Asn Glu Met Leu Gly 370 375 380 Leu Glu Glu Gly Asp Leu Glu Asp Asp Phe Asp Pro Ala Gln His Asp 385 390 395 400 Gln Leu Met Gln Lys Cys Phe Gly Asp Glu Tyr Tyr Gly Ala Val Glu 405 410 415 Glu Glu Lys Pro Gln Phe Glu Glu Glu Glu Gly Leu Glu Asp Asp Trp 420 425 430 Asn Trp Asp Thr Trp Asp Gly Pro Glu Gln Glu Gly Asp Trp Ser Gln 435 440 445 Gln Glu Leu His Cys Glu Asp Pro Asn Phe Asn Met Asp Ala Asp Tyr 450 455 460 Asp Pro Ser Gln Pro Arg Lys Lys Lys Arg Glu Ala Pro Leu Thr Gly 465 470 475 480 Lys Lys Lys Arg Lys Ser Pro Phe Ala Ala Ala Val Gly Gln Glu Lys 485 490 495 Pro Val Phe Glu Pro Gly Asp Lys Thr Phe Glu Glu Tyr Leu Asp Glu 500 505 510 Tyr Tyr Arg Leu Asp Tyr Glu Asp Ile Ile Asp Asp Leu Pro Cys Arg 515 520 525 Phe Lys Tyr Arg Thr Val Val Pro Cys Asp Phe Gly Leu Ser Thr Glu 530 535 540 Glu Ile Leu Ala Ala Asp Asp Lys Glu Leu Asn Arg Trp Cys Ser Leu 545 550 555 560 Lys Lys Thr Cys Met Tyr Arg Ser Glu Gln Glu Glu Leu Arg Asp Lys 565 570 575 Arg Ala Tyr Ser Gln Lys Ala Gln Asn Ser Trp Lys Lys Arg Gln Val 580 585 590 Phe Lys Ser Leu Cys Arg Glu Glu Ala Glu Thr Pro Ala Glu Ala Thr 595 600 605 Gly Lys Pro Gln Arg Asp Glu Ala Gly Pro Gln Arg Gln Leu Pro Ala 610 615 620 Leu Asp Gly Ser Leu Met Gly Pro Glu Ser Pro Pro Ala Gln Glu Glu 625 630 635 640 Glu Ala Pro Val Ser Pro His Lys Lys Pro Ala Pro Gln Lys Arg Arg 645 650 655 Arg Ala Lys Lys Ala Arg Leu Leu Gly Pro Thr Val Met Leu Gly Gly 660 665 670 Cys Glu Phe Ser Arg Gln Arg Leu Gln Ala Phe Gly Leu Asn Pro Lys 675 680 685 Arg Leu His Phe Arg Gln Leu Gly Arg Gln Arg Arg Lys Gln Gln Gly 690 695 700 Pro Lys Asn Ser Ser 705 <210> SEQ ID NO 89 <211> LENGTH: 1198 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 89 Met Ala Pro Val Tyr Glu Gly Met Ala Ser His Val Gln Val Phe Ser 1 5 10 15 Pro His Thr Leu Gln Ser Ser Ala Phe Cys Ser Val Lys Lys Leu Lys 20 25 30 Val Glu Pro Ser Ser Asn Trp Asp Met Thr Gly Tyr Gly Ser His Ser 35 40 45 Lys Val Tyr Ser Gln Ser Lys Asn Ile Pro Pro Ser Gln Pro Ala Ser 50 55 60 Thr Thr Val Ser Thr Ser Leu Pro Val Pro Asn Pro Ser Leu Pro Tyr 65 70 75 80 Glu Gln Thr Ile Val Phe Pro Gly Ser Thr Gly His Ile Val Val Thr 85 90 95

Ser Ala Ser Ser Thr Ser Val Thr Gly Gln Val Leu Gly Gly Pro His 100 105 110 Asn Leu Met Arg Arg Ser Thr Val Ser Leu Leu Asp Thr Tyr Gln Lys 115 120 125 Cys Gly Leu Lys Arg Lys Ser Glu Glu Ile Glu Asn Thr Ser Ser Val 130 135 140 Gln Ile Ile Glu Glu His Pro Pro Met Ile Gln Asn Asn Ala Ser Gly 145 150 155 160 Ala Thr Val Ala Thr Ala Thr Thr Ser Thr Ala Thr Ser Lys Asn Ser 165 170 175 Gly Ser Asn Ser Glu Gly Asp Tyr Gln Leu Val Gln His Glu Val Leu 180 185 190 Cys Ser Met Thr Asn Thr Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly 195 200 205 Thr Phe Gly Gln Val Val Lys Cys Trp Lys Arg Gly Thr Asn Glu Ile 210 215 220 Val Ala Ile Lys Ile Leu Lys Asn Arg Pro Ser Tyr Ala Arg Gln Gly 225 230 235 240 Gln Ile Glu Val Ser Ile Leu Ala Arg Leu Ser Thr Glu Ser Ala Asp 245 250 255 Asp Tyr Asn Phe Val Arg Ala Tyr Glu Cys Phe Gln His Lys Asn His 260 265 270 Thr Cys Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu 275 280 285 Lys Gln Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Val 290 295 300 Leu Gln Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu 305 310 315 320 Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Ser 325 330 335 Arg Gln Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His 340 345 350 Val Ser Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg 355 360 365 Ala Pro Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met 370 375 380 Trp Ser Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu 385 390 395 400 Tyr Pro Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr 405 410 415 Gln Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr 420 425 430 Arg Phe Phe Asn Arg Asp Thr Asp Ser Pro Tyr Pro Leu Trp Arg Leu 435 440 445 Lys Thr Pro Asp Asp His Glu Ala Glu Thr Gly Ile Lys Ser Lys Glu 450 455 460 Ala Arg Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn 465 470 475 480 Met Thr Thr Asp Leu Glu Gly Ser Asp Met Leu Val Glu Lys Ala Asp 485 490 495 Arg Arg Glu Phe Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala 500 505 510 Asp Lys Arg Ile Thr Pro Ile Glu Thr Leu Asn His Pro Phe Val Thr 515 520 525 Met Thr His Leu Leu Asp Phe Pro His Ser Thr His Val Lys Ser Cys 530 535 540 Phe Gln Asn Met Glu Ile Cys Lys Arg Arg Val Asn Met Tyr Asp Thr 545 550 555 560 Val Asn Gln Ser Lys Thr Pro Phe Ile Thr His Val Ala Pro Ser Thr 565 570 575 Ser Thr Asn Leu Thr Met Thr Phe Asn Asn Gln Leu Thr Thr Val His 580 585 590 Asn Gln Ala Pro Ser Ser Thr Ser Ala Thr Ile Ser Leu Ala Asn Pro 595 600 605 Glu Val Ser Ile Leu Asn Tyr Pro Ser Thr Leu Tyr Gln Pro Ser Ala 610 615 620 Ala Ser Met Ala Ala Val Ala Gln Arg Ser Met Pro Leu Gln Thr Gly 625 630 635 640 Thr Ala Gln Ile Cys Ala Arg Pro Asp Pro Phe Gln Gln Ala Leu Ile 645 650 655 Val Cys Pro Pro Gly Phe Gln Gly Leu Gln Ala Ser Pro Ser Lys His 660 665 670 Ala Gly Tyr Ser Val Arg Met Glu Asn Ala Val Pro Ile Val Thr Gln 675 680 685 Ala Pro Gly Ala Gln Pro Leu Gln Ile Gln Pro Gly Leu Leu Ala Gln 690 695 700 Gln Ala Trp Pro Ser Gly Thr Gln Gln Ile Leu Leu Pro Pro Ala Trp 705 710 715 720 Gln Gln Leu Thr Gly Val Ala Thr His Thr Ser Val Gln His Ala Thr 725 730 735 Val Ile Pro Glu Thr Met Ala Gly Thr Gln Gln Leu Ala Asp Trp Arg 740 745 750 Asn Thr His Ala His Gly Ser His Tyr Asn Pro Ile Met Gln Gln Pro 755 760 765 Ala Leu Leu Thr Gly His Val Thr Leu Pro Ala Ala Gln Pro Leu Asn 770 775 780 Val Gly Val Ala His Val Met Arg Gln Gln Pro Thr Ser Thr Thr Ser 785 790 795 800 Ser Arg Lys Ser Lys Gln His Gln Ser Ser Val Arg Asn Val Ser Thr 805 810 815 Cys Glu Val Ser Ser Ser Gln Ala Ile Ser Ser Pro Gln Arg Ser Lys 820 825 830 Arg Val Lys Glu Asn Thr Pro Pro Arg Cys Ala Met Val His Ser Ser 835 840 845 Pro Ala Cys Ser Thr Ser Val Thr Cys Gly Trp Gly Asp Val Ala Ser 850 855 860 Ser Thr Thr Arg Glu Arg Gln Arg Gln Thr Ile Val Ile Pro Asp Thr 865 870 875 880 Pro Ser Pro Thr Val Ser Val Ile Thr Ile Ser Ser Asp Thr Asp Glu 885 890 895 Glu Glu Glu Gln Lys His Ala Pro Thr Ser Thr Val Ser Lys Gln Arg 900 905 910 Lys Asn Val Ile Ser Cys Val Thr Val His Asp Ser Pro Tyr Ser Asp 915 920 925 Ser Ser Ser Asn Thr Ser Pro Tyr Ser Val Gln Gln Arg Ala Gly His 930 935 940 Asn Asn Ala Asn Ala Phe Asp Thr Lys Gly Ser Leu Glu Asn His Cys 945 950 955 960 Thr Gly Asn Pro Arg Thr Ile Ile Val Pro Pro Leu Lys Thr Gln Ala 965 970 975 Ser Glu Val Leu Val Glu Cys Asp Ser Leu Val Pro Val Asn Thr Ser 980 985 990 His His Ser Ser Ser Tyr Lys Ser Lys Ser Ser Ser Asn Val Thr Ser 995 1000 1005 Thr Ser Gly His Ser Ser Gly Ser Ser Ser Gly Ala Ile Thr Tyr Arg 1010 1015 1020 Gln Gln Arg Pro Gly Pro His Phe Gln Gln Gln Gln Pro Leu Asn Leu 1025 1030 1035 1040 Ser Gln Ala Gln Gln His Ile Thr Thr Asp Arg Thr Gly Ser His Arg 1045 1050 1055 Arg Gln Gln Ala Tyr Ile Thr Pro Thr Met Ala Gln Ala Pro Tyr Ser 1060 1065 1070 Phe Pro His Asn Ser Pro Ser His Gly Thr Val His Pro His Leu Ala 1075 1080 1085 Ala Ala Ala Ala Ala Ala His Leu Pro Thr Gln Pro His Leu Tyr Thr 1090 1095 1100 Tyr Thr Ala Pro Ala Ala Leu Gly Ser Thr Gly Thr Val Ala His Leu 1105 1110 1115 1120 Val Ala Ser Gln Gly Ser Ala Arg His Thr Val Gln His Thr Ala Tyr 1125 1130 1135 Pro Ala Ser Ile Val His Gln Val Pro Val Ser Met Gly Pro Arg Val 1140 1145 1150 Leu Pro Ser Pro Thr Ile His Pro Ser Gln Tyr Pro Ala Gln Phe Ala 1155 1160 1165 His Gln Thr Tyr Ile Ser Ala Ser Pro Ala Ser Thr Val Tyr Thr Gly 1170 1175 1180 Tyr Pro Leu Ser Pro Ala Lys Val Asn Gln Tyr Pro Tyr Ile 1185 1190 1195 <210> SEQ ID NO 90 <211> LENGTH: 1022 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Met Arg Val Gln Leu Leu Gln Asp Leu Gln Asp Phe Phe Arg Lys Lys 1 5 10 15 Ala Glu Ile Glu Thr Glu Tyr Ser Arg Asn Leu Glu Lys Leu Ala Glu 20 25 30 Arg Phe Met Ala Lys Thr Arg Ser Thr Lys Asp His Gln Gln Tyr Lys 35 40 45 Lys Asp Gln Asn Leu Leu Ser Pro Val Asn Cys Trp Tyr Leu Leu Leu 50 55 60 Asn Gln Val Arg Arg Glu Ser Lys Asp His Ala Thr Leu Ser Asp Ile 65 70 75 80 Tyr Leu Asn Asn Val Ile Met Arg Phe Met Gln Ile Ser Glu Asp Ser 85 90 95 Thr Arg Met Phe Lys Lys Ser Lys Glu Ile Ala Phe Gln Leu His Glu 100 105 110 Asp Leu Met Lys Val Leu Asn Glu Leu Tyr Thr Val Met Lys Thr Tyr 115 120 125 His Met Tyr His Ala Glu Ser Ile Ser Ala Glu Ser Lys Leu Lys Glu 130 135 140 Ala Glu Lys Gln Glu Glu Lys Gln Ile Gly Arg Ser Gly Asp Pro Val 145 150 155 160 Phe His Ile Arg Leu Glu Glu Arg His Gln Arg Arg Ser Ser Val Lys 165 170 175 Lys Ile Glu Lys Met Lys Glu Lys Arg Gln Ala Lys Tyr Ser Glu Asn 180 185 190

Lys Leu Lys Ser Ile Lys Ala Arg Asn Glu Tyr Leu Leu Thr Leu Glu 195 200 205 Ala Thr Asn Ala Ser Val Phe Lys Tyr Tyr Ile His Asp Leu Ser Asp 210 215 220 Leu Ile Asp Cys Cys Asp Leu Gly Tyr His Ala Ser Leu Asn Arg Ala 225 230 235 240 Leu Arg Thr Tyr Leu Ser Ala Glu Tyr Asn Leu Glu Thr Ser Arg His 245 250 255 Glu Gly Leu Asp Ile Ile Glu Asn Ala Val Asp Asn Leu Glu Pro Arg 260 265 270 Ser Asp Lys Gln Arg Phe Met Glu Met Tyr Pro Ala Ala Phe Cys Pro 275 280 285 Pro Met Lys Phe Glu Phe Gln Ser His Met Gly Asp Glu Val Cys Gln 290 295 300 Val Ser Ala Gln Gln Pro Val Gln Ala Glu Leu Met Leu Arg Tyr Gln 305 310 315 320 Gln Leu Gln Ser Arg Leu Ala Thr Leu Lys Ile Glu Asn Glu Glu Val 325 330 335 Lys Lys Thr Thr Glu Ala Thr Leu Gln Thr Ile Gln Asp Met Val Thr 340 345 350 Ile Glu Asp Tyr Asp Val Ser Glu Cys Phe Gln His Ser Arg Ser Thr 355 360 365 Glu Ser Val Lys Ser Thr Val Ser Glu Thr Tyr Leu Ser Lys Pro Ser 370 375 380 Ile Ala Lys Arg Arg Ala Asn Gln Gln Glu Thr Glu Gln Phe Tyr Phe 385 390 395 400 Met Lys Leu Arg Glu Tyr Leu Glu Gly Ser Asn Leu Ile Thr Lys Leu 405 410 415 Gln Ala Lys His Asp Leu Leu Gln Arg Thr Leu Gly Glu Gly His Arg 420 425 430 Ala Glu Tyr Met Thr Thr Ser Arg Gly Arg Arg Asn Ser His Thr Arg 435 440 445 His Gln Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys Ile 450 455 460 Arg Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg Val 465 470 475 480 Ser Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu Arg 485 490 495 Gly Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn Ser 500 505 510 Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro Leu 515 520 525 Phe Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile Asp 530 535 540 Asn Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr Leu 545 550 555 560 Pro Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu Asn 565 570 575 His Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu 580 585 590 Ala Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln Asp 595 600 605 Gln Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile Ile 610 615 620 Ile His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly Pro 625 630 635 640 Val Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro Tyr 645 650 655 Ser Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr Glu 660 665 670 Pro His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala Lys 675 680 685 Phe Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys Gly 690 695 700 Ala Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu Gly 705 710 715 720 Arg His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val Val 725 730 735 Gln Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala Asp 740 745 750 Ser Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser Lys 755 760 765 Asp Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala Arg 770 775 780 Gln Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly Arg 785 790 795 800 Thr Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser Asn 805 810 815 Ser Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg Gly 820 825 830 Leu Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg Arg 835 840 845 Arg Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser Leu 850 855 860 Lys Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly Gln 865 870 875 880 Tyr Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile Ala 885 890 895 Gln Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg Glu 900 905 910 Leu Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu Asp 915 920 925 Thr Leu Glu Gln Val Lys Asn Ser Pro Thr Pro Ala Thr Ser Thr Glu 930 935 940 Ser Leu Ser Pro Leu His Asn Val Ala Leu Arg Ser Ser Glu Pro Gln 945 950 955 960 Ile Arg Arg Ser Thr Ser Ser Ser Ser Asp Thr Met Ser Thr Phe Lys 965 970 975 Pro Met Val Ala Pro Arg Met Gly Val Gln Leu Lys Pro Pro Ala Leu 980 985 990 Arg Pro Lys Pro Ala Val Leu Pro Lys Thr Asn Pro Thr Ile Gly Pro 995 1000 1005 Ala Pro Pro Pro Gln Gly Pro Thr Asp Lys Ser Cys Thr Met 1010 1015 1020 <210> SEQ ID NO 91 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 91 Met Ala Ala Ser Gly Arg Gly Leu Cys Lys Ala Val Ala Ala Ser Pro 1 5 10 15 Phe Pro Ala Trp Arg Arg Asp Asn Thr Glu Ala Arg Gly Gly Leu Lys 20 25 30 Pro Glu Tyr Asp Ala Val Val Ile Gly Ala Gly His Asn Gly Leu Val 35 40 45 Ala Ala Ala Tyr Leu Gln Arg Leu Gly Val Asn Thr Ala Val Phe Glu 50 55 60 Arg Arg His Val Ile Gly Gly Ala Ala Val Thr Glu Glu Ile Ile Pro 65 70 75 80 Gly Phe Lys Phe Ser Arg Ala Ser Tyr Leu Leu Ser Leu Leu Arg Pro 85 90 95 Gln Ile Tyr Thr Asp Leu Glu Leu Lys Lys His Gly Leu Arg Leu His 100 105 110 Leu Arg Asn Pro Tyr Ser Phe Thr Pro Met Leu Glu Glu Gly Ala Gly 115 120 125 Ser Lys Val Pro Arg Cys Leu Leu Leu Gly Thr Asp Met Ala Glu Asn 130 135 140 Gln Lys Gln Ile Ala Gln Phe Ser Gln Lys Asp Ala Gln Val Phe Pro 145 150 155 160 Lys Tyr Glu Glu Phe Met His Arg Leu Ala Leu Ala Ile Asp Pro Leu 165 170 175 Leu Asp Ala Ala Pro Val Asp Met Ala Ala Phe Gln His Gly Ser Leu 180 185 190 Leu Gln Arg Met Arg Ser Leu Ser Thr Leu Lys Pro Leu Leu Lys Ala 195 200 205 Gly Arg Ile Leu Gly Ala Gln Leu Pro Arg Tyr Tyr Glu Val Leu Thr 210 215 220 Ala Pro Ile Thr Lys Val Leu Asp Gln Trp Phe Glu Ser Glu Pro Leu 225 230 235 240 Lys Ala Thr Leu Ala Thr Asp Ala Val Ile Gly Ala Met Thr Ser Pro 245 250 255 His Thr Pro Gly Ser Gly Tyr Val Leu Leu His His Val Met Gly Gly 260 265 270 Leu Glu Gly Met Gln Gly Ala Trp Gly Tyr Val Gln Gly Gly Met Gly 275 280 285 Ala Leu Ser Asp Ala Ile Ala Ser Ser Ala Thr Thr His Gly Ala Ser 290 295 300 Ile Phe Thr Glu Lys Thr Val Ala Lys Val Gln Val Asn Ser Glu Gly 305 310 315 320 Cys Val Gln Gly Val Val Leu Glu Asp Gly Thr Glu Val Arg Ser Lys 325 330 335 Met Val Leu Ser Asn Thr Ser Pro Gln Ile Thr Phe Leu Lys Leu Thr 340 345 350 Pro Gln Glu Trp Leu Pro Glu Glu Phe Leu Glu Arg Ile Ser Gln Leu 355 360 365 Asp Thr Arg Ser Pro Val Thr Lys Ile Asn Val Ala Val Asp Arg Leu 370 375 380 Pro Ser Phe Leu Ala Ala Pro Asn Ala Pro Arg Gly Gln Pro Leu Pro 385 390 395 400 His His Gln Cys Ser Ile His Leu Asn Cys Glu Asp Thr Leu Leu Leu 405 410 415 His Gln Ala Phe Glu Asp Ala Met Asp Gly Leu Ser Ser His Arg Pro 420 425 430 Val Ile Glu Leu Cys Ile Pro Ser Ser Leu Asp Pro Thr Leu Ala Pro 435 440 445 Pro Gly Cys His Val Val Ser Leu Phe Thr Gln Tyr Thr Pro Tyr Thr 450 455 460

Leu Ala Gly Gly Lys Ala Trp Asp Glu Gln Glu Arg Asp Ala Tyr Ala 465 470 475 480 Asp Arg Val Phe Asp Cys Ile Glu Val Tyr Ala Pro Gly Phe Lys Asp 485 490 495 Ser Val Val Gly Arg Asp Ile Leu Thr Pro Pro Asp Leu Glu Arg Ile 500 505 510 Phe Gly Leu Pro Gly Gly Asn Ile Phe His Cys Ala Met Ser Leu Asp 515 520 525 Gln Leu Tyr Phe Ala Arg Pro Val Pro Leu His Ser Gly Tyr Arg Cys 530 535 540 Pro Leu Gln Gly Leu Tyr Leu Cys Gly Ser Gly Ala His Pro Gly Gly 545 550 555 560 Gly Val Met Gly Ala Ala Gly Arg Asn Ala Ala His Val Ala Phe Arg 565 570 575 Asp Leu Lys Ser Met 580 <210> SEQ ID NO 92 <211> LENGTH: 498 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 92 Met Pro Leu Val Thr Arg Asn Ile Glu Pro Arg His Leu Cys Arg Gln 1 5 10 15 Thr Leu Pro Ser Val Arg Ser Glu Leu Glu Cys Val Thr Asn Ile Thr 20 25 30 Leu Ala Asn Val Ile Arg Gln Leu Gly Ser Leu Ser Lys Tyr Ala Glu 35 40 45 Asp Ile Phe Gly Glu Leu Phe Thr Gln Ala Asn Thr Phe Ala Ser Arg 50 55 60 Val Ser Ser Leu Ala Glu Arg Val Asp Arg Leu Gln Val Lys Val Thr 65 70 75 80 Gln Leu Asp Pro Lys Glu Glu Glu Val Ser Leu Gln Gly Ile Asn Thr 85 90 95 Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Lys Leu Phe Asp 100 105 110 Arg Asn Ser Leu Pro Val Pro Val Leu Glu Thr Tyr Asn Thr Cys Asp 115 120 125 Thr Pro Pro Pro Leu Asn Asn Leu Thr Pro Tyr Arg Asp Asp Gly Lys 130 135 140 Glu Ala Leu Lys Phe Tyr Thr Asp Pro Ser Tyr Phe Phe Asp Leu Trp 145 150 155 160 Lys Glu Lys Met Leu Gln Asp Thr Lys Asp Ile Met Lys Glu Lys Arg 165 170 175 Lys His Arg Lys Glu Lys Lys Asp Asn Pro Asn Arg Gly Asn Val Asn 180 185 190 Pro Arg Lys Ile Lys Thr Arg Lys Glu Glu Trp Glu Lys Met Lys Met 195 200 205 Gly Gln Glu Phe Val Glu Ser Lys Glu Lys Leu Gly Thr Ser Gly Tyr 210 215 220 Pro Pro Thr Leu Val Tyr Gln Asn Gly Ser Ile Gly Cys Val Glu Asn 225 230 235 240 Val Asp Ala Ser Ser Tyr Pro Pro Pro Pro Gln Ser Asp Ser Ala Ser 245 250 255 Ser Pro Ser Pro Ser Phe Ser Glu Asp Asn Leu Pro Pro Pro Pro Ala 260 265 270 Glu Phe Ser Tyr Pro Val Asp Asn Gln Arg Gly Ser Gly Leu Ala Gly 275 280 285 Pro Lys Arg Ser Ser Val Val Ser Pro Ser His Pro Pro Pro Ala Pro 290 295 300 Pro Leu Gly Ser Pro Pro Gly Pro Lys Pro Gly Phe Ala Pro Pro Pro 305 310 315 320 Ala Pro Pro Pro Pro Pro Pro Pro Met Ile Gly Ile Pro Pro Pro Pro 325 330 335 Pro Pro Val Gly Phe Gly Ser Pro Gly Thr Pro Pro Pro Pro Ser Pro 340 345 350 Pro Ser Phe Pro Pro His Pro Asp Phe Ala Ala Pro Pro Pro Pro Pro 355 360 365 Pro Pro Pro Ala Ala Asp Tyr Pro Thr Leu Pro Pro Pro Pro Leu Ser 370 375 380 Gln Pro Thr Gly Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 385 390 395 400 Gly Pro Pro Pro Pro Pro Phe Thr Gly Ala Asp Gly Gln Pro Ala Ile 405 410 415 Pro Pro Pro Leu Ser Asp Thr Thr Lys Pro Lys Ser Ser Leu Pro Ala 420 425 430 Val Ser Asp Ala Arg Ser Asp Leu Leu Ser Ala Ile Arg Gln Gly Phe 435 440 445 Gln Leu Arg Arg Val Glu Glu Gln Arg Glu Gln Glu Lys Arg Asp Val 450 455 460 Val Gly Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu 465 470 475 480 Tyr Ser Asp Ser Glu Asp Asp Ser Ser Glu Phe Asp Glu Asp Asp Trp 485 490 495 Ser Asp <210> SEQ ID NO 93 <211> LENGTH: 1138 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 93 Met Ala Leu Lys Met Val Lys Gly Ser Ile Asp Arg Met Phe Asp Lys 1 5 10 15 Asn Leu Gln Asp Leu Val Arg Gly Ile Arg Asn His Lys Glu Asp Glu 20 25 30 Ala Lys Tyr Ile Ser Gln Cys Ile Asp Glu Ile Lys Gln Glu Leu Lys 35 40 45 Gln Asp Asn Ile Ala Val Lys Ala Asn Ala Val Cys Lys Leu Thr Tyr 50 55 60 Leu Gln Met Leu Gly Tyr Asp Ile Ser Trp Ala Ala Phe Asn Ile Ile 65 70 75 80 Glu Val Met Ser Ala Ser Lys Phe Thr Phe Lys Arg Ile Gly Tyr Leu 85 90 95 Ala Ala Ser Gln Ser Phe His Glu Gly Thr Asp Val Ile Met Leu Thr 100 105 110 Thr Asn Gln Ile Arg Lys Asp Leu Ser Ser Pro Ser Gln Tyr Asp Thr 115 120 125 Gly Val Ala Leu Thr Gly Leu Ser Cys Phe Val Thr Pro Asp Leu Ala 130 135 140 Arg Asp Leu Ala Asn Asp Ile Met Thr Leu Met Ser His Thr Lys Pro 145 150 155 160 Tyr Ile Arg Lys Lys Ala Val Leu Ile Met Tyr Lys Val Phe Leu Lys 165 170 175 Tyr Pro Glu Ser Leu Arg Pro Ala Phe Pro Arg Leu Lys Glu Lys Leu 180 185 190 Glu Asp Pro Asp Pro Gly Val Gln Ser Ala Ala Val Asn Val Ile Cys 195 200 205 Glu Leu Ala Arg Arg Asn Pro Lys Asn Tyr Leu Ser Leu Ala Pro Leu 210 215 220 Phe Phe Lys Leu Met Thr Ser Ser Thr Asn Asn Trp Val Leu Ile Lys 225 230 235 240 Ile Ile Lys Leu Phe Gly Ala Leu Thr Pro Leu Glu Pro Arg Leu Gly 245 250 255 Lys Lys Leu Ile Glu Pro Leu Thr Asn Leu Ile His Ser Thr Ser Ala 260 265 270 Met Ser Leu Leu Tyr Glu Cys Val Asn Thr Val Ile Ala Val Leu Ile 275 280 285 Ser Leu Ser Ser Gly Met Pro Asn His Ser Ala Ser Ile Gln Leu Cys 290 295 300 Val Gln Lys Leu Arg Ile Leu Ile Glu Asp Ser Asp Gln Asn Leu Lys 305 310 315 320 Tyr Leu Gly Leu Leu Ala Met Ser Lys Ile Leu Lys Thr His Pro Lys 325 330 335 Ser Val Gln Ser His Lys Asp Leu Ile Leu Gln Cys Leu Asp Asp Lys 340 345 350 Asp Glu Ser Ile Arg Leu Arg Ala Leu Asp Leu Leu Tyr Gly Met Val 355 360 365 Ser Lys Lys Asn Leu Met Glu Ile Val Lys Lys Leu Met Thr His Val 370 375 380 Asp Lys Ala Glu Gly Thr Thr Tyr Arg Asp Glu Leu Leu Thr Lys Ile 385 390 395 400 Ile Asp Ile Cys Ser Gln Ser Asn Tyr Gln Tyr Ile Thr Asn Phe Glu 405 410 415 Trp Tyr Ile Ser Ile Leu Val Glu Leu Thr Arg Leu Glu Gly Thr Arg 420 425 430 His Gly His Leu Ile Ala Ala Gln Met Leu Asp Val Ala Ile Arg Val 435 440 445 Lys Ala Ile Arg Lys Phe Ala Val Ser Gln Met Ser Ala Leu Leu Asp 450 455 460 Ser Ala His Leu Leu Ala Ser Ser Thr Gln Arg Asn Gly Ile Cys Glu 465 470 475 480 Val Leu Tyr Ala Ala Ala Trp Ile Cys Gly Glu Phe Ser Glu His Leu 485 490 495 Gln Glu Pro His His Thr Leu Glu Ala Met Leu Arg Pro Arg Val Thr 500 505 510 Thr Leu Pro Gly His Ile Gln Ala Val Tyr Val Gln Asn Val Val Lys 515 520 525 Leu Tyr Ala Ser Ile Leu Gln Gln Lys Glu Gln Ala Gly Glu Ala Glu 530 535 540 Gly Ala Gln Ala Val Thr Gln Leu Met Val Asp Arg Leu Pro Gln Phe 545 550 555 560 Val Gln Ser Ala Asp Leu Glu Val Gln Glu Arg Ala Ser Cys Ile Leu 565 570 575 Gln Leu Val Lys His Ile Gln Lys Leu Gln Ala Lys Asp Val Pro Val 580 585 590 Ala Glu Glu Val Ser Ala Leu Phe Ala Gly Glu Leu Asn Pro Val Ala 595 600 605 Pro Lys Ala Gln Lys Lys Val Pro Val Pro Glu Gly Leu Asp Leu Asp 610 615 620

Ala Trp Ile Asn Glu Pro Leu Ser Asp Ser Glu Ser Glu Asp Glu Arg 625 630 635 640 Pro Arg Ala Val Phe His Glu Glu Glu Gln Arg Arg Pro Lys His Arg 645 650 655 Pro Ser Glu Ala Asp Glu Glu Glu Leu Ala Arg Arg Arg Glu Ala Arg 660 665 670 Lys Gln Glu Gln Ala Asn Asn Pro Phe Tyr Ile Lys Ser Ser Pro Ser 675 680 685 Pro Gln Lys Arg Tyr Gln Asp Thr Pro Gly Val Glu His Ile Pro Val 690 695 700 Val Gln Ile Asp Leu Ser Val Pro Leu Lys Val Pro Gly Leu Pro Met 705 710 715 720 Ser Asp Gln Tyr Val Lys Leu Glu Glu Glu Arg Arg His Arg Gln Lys 725 730 735 Leu Glu Lys Asp Lys Arg Arg Lys Lys Arg Lys Glu Lys Glu Lys Lys 740 745 750 Gly Lys Arg Arg His Ser Ser Leu Pro Thr Glu Ser Asp Glu Asp Ile 755 760 765 Ala Pro Ala Gln Gln Val Asp Ile Val Thr Glu Glu Met Pro Glu Asn 770 775 780 Ala Leu Pro Ser Asp Glu Asp Asp Lys Asp Pro Asn Asp Pro Tyr Arg 785 790 795 800 Ala Leu Asp Ile Asp Leu Asp Lys Pro Leu Ala Asp Ser Glu Lys Leu 805 810 815 Pro Ile Gln Lys His Arg Asn Thr Glu Thr Ser Lys Ser Pro Glu Lys 820 825 830 Asp Val Pro Met Val Glu Lys Lys Ser Lys Lys Pro Lys Lys Lys Glu 835 840 845 Lys Lys His Lys Glu Lys Glu Arg Asp Lys Glu Lys Lys Lys Glu Lys 850 855 860 Glu Lys Lys Lys Ser Pro Lys Pro Lys Lys Lys Lys His Arg Lys Glu 865 870 875 880 Lys Glu Glu Arg Thr Lys Gly Lys Lys Lys Ser Lys Lys Gln Pro Pro 885 890 895 Gly Ser Glu Glu Ala Ala Gly Glu Pro Val Gln Asn Gly Ala Pro Glu 900 905 910 Glu Glu Gln Leu Pro Pro Glu Ser Ser Tyr Ser Leu Leu Ala Glu Asn 915 920 925 Ser Tyr Val Lys Met Thr Cys Asp Ile Arg Gly Ser Leu Gln Glu Asp 930 935 940 Ser Gln Val Thr Val Ala Ile Val Leu Glu Asn Arg Ser Ser Ser Ile 945 950 955 960 Leu Lys Gly Met Glu Leu Ser Val Leu Asp Ser Leu Asn Ala Arg Met 965 970 975 Ala Arg Pro Gln Gly Ser Ser Val His Asp Gly Val Pro Val Pro Phe 980 985 990 Gln Leu Pro Pro Gly Val Ser Asn Glu Ala Gln Tyr Val Phe Thr Ile 995 1000 1005 Gln Ser Ile Val Met Ala Gln Lys Leu Lys Gly Thr Leu Ser Phe Ile 1010 1015 1020 Ala Lys Asn Asp Glu Gly Ala Thr His Glu Lys Leu Asp Phe Arg Leu 102 1030 1035 1040 His Phe Ser Cys Ser Ser Tyr Leu Ile Thr Thr Pro Cys Tyr Ser Asp 1045 1050 1055 Ala Phe Ala Lys Leu Leu Glu Ser Gly Asp Leu Ser Met Ser Ser Ile 1060 1065 1070 Lys Val Asp Gly Ile Arg Met Ser Phe Gln Asn Leu Leu Ala Lys Ile 1075 1080 1085 Cys Phe His His His Phe Ser Val Val Glu Arg Val Asp Ser Cys Ala 1090 1095 1100 Ser Met Tyr Ser Arg Ser Ile Gln Gly His His Val Cys Leu Leu Val 1105 1110 1115 1120 Lys Lys Val Arg Thr Leu Ser Gln Ser Thr Gly Ser Ala Val Thr Pro 1125 1130 1135 Arg Tyr <210> SEQ ID NO 94 <211> LENGTH: 227 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 94 Met Phe Glu Pro Val Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Gly 1 5 10 15 Glu Ser Arg Glu Ala Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro 20 25 30 Arg Asp Ala Gln Leu Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala 35 40 45 Val Asn Thr His Cys His Ala Asp His Ile Thr Gly Ser Gly Leu Leu 50 55 60 Arg Ser Leu Leu Pro Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly 65 70 75 80 Ala Gln Ala Asp Leu His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly 85 90 95 Arg Phe Ala Leu Glu Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys 100 105 110 Val Thr Phe Val Leu Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala 115 120 125 Leu Leu Ile Arg Gly Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala 130 135 140 Lys Thr Leu Tyr His Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly 145 150 155 160 Asp Cys Leu Ile Tyr Pro Ala His Asp Tyr His Gly Phe Thr Val Ser 165 170 175 Thr Val Glu Glu Glu Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys 180 185 190 Glu Glu Phe Val Lys Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln 195 200 205 Gln Ile Asp Phe Ala Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr 210 215 220 Pro Thr Ala 225 <210> SEQ ID NO 95 <211> LENGTH: 640 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 95 Met His Val Lys Lys Tyr Leu Leu Lys Gly Leu His Arg Leu Gln Lys 1 5 10 15 Gly Pro Gly Tyr Thr Tyr Lys Glu Leu Leu Val Trp Tyr Cys Asp Asn 20 25 30 Thr Asn Thr His Gly Pro Lys Arg Ile Ile Cys Glu Gly Pro Lys Lys 35 40 45 Lys Ala Met Trp Phe Leu Leu Thr Leu Leu Phe Ala Ala Leu Val Cys 50 55 60 Trp Gln Trp Gly Ile Phe Ile Arg Thr Tyr Leu Ser Trp Glu Val Ser 65 70 75 80 Val Ser Leu Ser Val Gly Phe Lys Thr Met Asp Phe Pro Ala Val Thr 85 90 95 Ile Cys Asn Ala Ser Pro Phe Lys Tyr Ser Lys Ile Lys His Leu Leu 100 105 110 Lys Asp Leu Asp Glu Leu Met Glu Ala Val Leu Glu Arg Ile Leu Ala 115 120 125 Pro Glu Leu Ser His Ala Asn Ala Thr Arg Asn Leu Asn Phe Ser Ile 130 135 140 Trp Asn His Thr Pro Leu Val Leu Ile Asp Glu Arg Asn Pro His His 145 150 155 160 Pro Met Val Leu Asp Leu Phe Gly Asp Asn His Asn Gly Leu Thr Ser 165 170 175 Ser Ser Ala Ser Glu Lys Ile Cys Asn Ala His Gly Cys Lys Met Ala 180 185 190 Met Arg Leu Cys Ser Leu Asn Arg Thr Gln Cys Thr Phe Arg Asn Phe 195 200 205 Thr Ser Ala Thr Gln Ala Leu Thr Glu Trp Tyr Ile Leu Gln Ala Thr 210 215 220 Asn Ile Phe Ala Gln Val Pro Gln Gln Glu Leu Val Glu Met Ser Tyr 225 230 235 240 Pro Gly Glu Gln Met Ile Leu Ala Cys Leu Phe Gly Ala Glu Pro Cys 245 250 255 Asn Tyr Arg Asn Phe Thr Ser Ile Phe Tyr Pro His Tyr Gly Asn Cys 260 265 270 Tyr Ile Phe Asn Trp Gly Met Thr Glu Lys Ala Leu Pro Ser Ala Asn 275 280 285 Pro Gly Thr Glu Phe Gly Leu Lys Leu Ile Leu Asp Ile Gly Gln Glu 290 295 300 Asp Tyr Val Pro Phe Leu Ala Ser Thr Gly Gly Val Arg Leu Met Leu 305 310 315 320 His Glu Gln Arg Ser Tyr Pro Phe Ile Arg Asp Glu Gly Ile Tyr Ala 325 330 335 Met Ser Gly Thr Glu Thr Ser Ile Gly Val Leu Val Asp Lys Leu Gln 340 345 350 Arg Met Gly Glu Pro Tyr Ser Pro Cys Thr Val Asn Gly Ser Glu Val 355 360 365 Pro Val Gln Asn Phe Tyr Ser Asp Tyr Asn Thr Thr Tyr Ser Ile Gln 370 375 380 Ala Cys Leu Arg Ser Cys Phe Gln Asp His Met Ile Arg Asn Cys Asn 385 390 395 400 Cys Gly His Tyr Leu Tyr Pro Leu Pro Arg Gly Glu Lys Tyr Cys Asn 405 410 415 Asn Arg Asp Phe Pro Asp Trp Ala His Cys Tyr Ser Asp Leu Gln Met 420 425 430 Ser Val Ala Gln Arg Glu Thr Cys Ile Gly Met Cys Lys Glu Ser Cys 435 440 445 Asn Asp Thr Gln Tyr Lys Met Thr Ile Ser Met Ala Asp Trp Pro Ser 450 455 460 Glu Ala Ser Glu Asp Trp Ile Phe His Val Leu Ser Gln Glu Arg Asp 465 470 475 480 Gln Ser Thr Asn Ile Thr Leu Ser Arg Lys Gly Ile Val Lys Leu Asn

485 490 495 Ile Tyr Phe Gln Glu Phe Asn Tyr Arg Thr Ile Glu Glu Ser Ala Ala 500 505 510 Asn Asn Ile Val Trp Leu Leu Ser Asn Leu Gly Gly Gln Phe Gly Phe 515 520 525 Trp Met Gly Gly Ser Val Leu Cys Leu Ile Glu Phe Gly Glu Ile Ile 530 535 540 Ile Asp Phe Val Trp Ile Thr Ile Ile Lys Leu Val Ala Leu Ala Lys 545 550 555 560 Ser Leu Arg Gln Arg Arg Ala Gln Ala Ser Tyr Ala Gly Pro Pro Pro 565 570 575 Thr Val Ala Glu Leu Val Glu Ala His Thr Asn Phe Gly Phe Gln Pro 580 585 590 Asp Thr Ala Pro Arg Ser Pro Asn Thr Gly Pro Tyr Pro Ser Glu Gln 595 600 605 Ala Leu Pro Ile Pro Gly Thr Pro Pro Pro Asn Tyr Asp Ser Leu Arg 610 615 620 Leu Gln Pro Leu Asp Val Ile Glu Ser Asp Ser Glu Gly Asp Ala Ile 625 630 635 640 <210> SEQ ID NO 96 <211> LENGTH: 1498 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 96 Val Lys Asp Leu Gly Ser Leu Asn Gly Thr Phe Val Asn Asp Met Arg 1 5 10 15 Ile Pro Asp Gln Lys Tyr Val Thr Leu Lys Leu Asn Asp Val Ile Arg 20 25 30 Phe Gly Tyr Asp Ser Asn Met Tyr Val Leu Glu Arg Val Gln His Arg 35 40 45 Val Pro Glu Glu Ala Leu Lys His Glu Lys Tyr Thr Ser Gln Leu Gln 50 55 60 Val Ser Val Lys Gly Leu Ala Pro Lys Arg Ser Glu Ala Leu Pro Glu 65 70 75 80 His Thr Pro Tyr Cys Glu Ala Ser Asn Pro Arg Pro Glu Lys Gly Asp 85 90 95 Arg Arg Pro Gly Thr Glu Ala Ala Ser Tyr Arg Thr Pro Leu Tyr Gly 100 105 110 Gln Pro Ser Trp Trp Gly Glu Asp Asp Gly Ser Thr Leu Pro Asp Ala 115 120 125 Gln Arg Gln Gly Glu Pro Tyr Pro Glu Arg Pro Lys Gly Pro Val Gln 130 135 140 Gln Asp Gly Glu Leu His Gly Phe Arg Ala Pro Ala Glu Pro Gln Gly 145 150 155 160 Cys Ser Phe Arg Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr Lys Glu 165 170 175 Thr Pro Gln Pro Ser Gln Pro Pro Glu Val Pro Ala His Glu Met Pro 180 185 190 Thr Lys Asp Ala Glu Ala Gly Gly Gly Gly Ala Ala Pro Val Val Gln 195 200 205 Ser His Ala Ser Phe Thr Ile Glu Phe Asp Asp Cys Ser Pro Gly Lys 210 215 220 Met Lys Ile Lys Asp His Ile Thr Lys Phe Ser Leu Arg Gln Arg Arg 225 230 235 240 Pro Pro Gly Lys Glu Ala Thr Pro Gly Glu Met Val Ser Ala Glu Thr 245 250 255 Lys Val Ala Asp Trp Leu Val Gln Asn Asp Pro Ser Leu Leu His Arg 260 265 270 Val Gly Pro Gly Asp Asp Arg His Ser Thr Lys Ser Asp Leu Pro Val 275 280 285 His Thr Arg Thr Leu Lys Gly His Lys His Glu Asp Gly Thr Gln Ser 290 295 300 Asp Ser Glu Asp Pro Leu Ala Lys Ala Ala Ser Ala Ala Gly Val Pro 305 310 315 320 Leu Glu Ala Ser Gly Gly Gln Val Arg Leu Gln Arg Gln Ile Lys Arg 325 330 335 Asp Pro Gln Glu Leu Leu His Asn Gln Gln Ala Phe Val Ile Glu Phe 340 345 350 Phe Asp Glu Asp Thr Pro Arg Lys Lys Arg Ser Gln Ser Phe Thr His 355 360 365 Ser Pro Ser Gly Asp Pro Lys Ala Asp Lys Arg Arg Gly Pro Thr Pro 370 375 380 Ala Asp Arg Asp Arg Pro Ser Val Pro Ala Pro Val Gln Ala Gly Gly 385 390 395 400 Arg Ser Ser Gly Pro Gln Arg Ala Gly Ser Leu Lys Arg Glu Lys Thr 405 410 415 Glu Glu Arg Leu Gly Ser Pro Ser Pro Ala Ser Arg Thr Pro Ala Arg 420 425 430 Pro Phe Gly Ser Val Gly Arg Arg Ser Arg Leu Ala Gln Asp Phe Met 435 440 445 Ala Gln Cys Leu Arg Glu Ser Ser Pro Ala Ala Arg Pro Ser Pro Glu 450 455 460 Lys Val Pro Pro Val Leu Pro Ala Pro Leu Thr Pro His Gly Thr Ser 465 470 475 480 Pro Val Gly Pro Pro Thr Pro Pro Pro Ala Pro Thr Asp Pro Gln Leu 485 490 495 Thr Lys Ala Arg Lys Gln Glu Glu Asp Asp Ser Leu Ser Asp Ala Gly 500 505 510 Thr Tyr Thr Ile Glu Thr Glu Ala Gln Asp Thr Glu Val Glu Glu Ala 515 520 525 Arg Lys Met Ile Asp Gln Val Phe Gly Val Leu Glu Ser Pro Glu Leu 530 535 540 Ser Arg Ala Ser Ser Ala Thr Phe Arg Pro Val Ile Arg Gly Asp Arg 545 550 555 560 Asp Glu Ser Asp Asp Gly Gly Val Ala Gln Arg Met Ala Leu Leu Gln 565 570 575 Glu Phe Ala Ser Arg Pro Leu Gly Ala Ala Pro Gln Ala Glu His Gln 580 585 590 Gly Leu Pro Val Pro Gly Ser Pro Gly Gly Gln Lys Trp Val Ser Arg 595 600 605 Trp Ala Ser Leu Ala Asp Ser Tyr Ser Asp Pro Gly Leu Thr Glu Asp 610 615 620 Gly Leu Gly Arg Arg Gly Gly Glu Pro Glu Gly Ser Leu Pro Val Arg 625 630 635 640 Met Arg Arg Arg Leu Pro Gln Leu Pro Ser Glu Arg Ala Asp Ser Pro 645 650 655 Ala Gly Pro Glu Ser Ser Arg Arg Ser Gly Pro Gly Pro Pro Glu Leu 660 665 670 Asp Ser Glu Gln Pro Ser Arg Leu Phe Gly Gln Glu Glu Leu Asp Pro 675 680 685 Asp Ser Leu Ser Asp Ala Ser Gly Ser Asp Gly Gly Arg Gly Pro Glu 690 695 700 Pro Gly Val Glu Pro Gln Asp Ser Arg Arg Arg Ser Pro Gln Glu Gly 705 710 715 720 Pro Thr Trp Ser Arg Gly Arg Arg Ser Pro Arg Ala Pro Gly Glu Pro 725 730 735 Thr Pro Ala Ser Phe Phe Ile Gly Asp Gln Asn Gly Asp Ala Val Leu 740 745 750 Ser Arg Lys Leu Leu Ala Ala Pro Gly Asp Gly Glu Gly Leu Gly Gln 755 760 765 Thr Ala Gln Pro Ser Pro Pro Ala Arg Asp Gly Val Tyr Val Ser Ala 770 775 780 Asn Gly Arg Met Val Ile Gln Leu Arg Pro Gly Arg Ser Pro Glu Pro 785 790 795 800 Asp Gly Pro Ala Pro Ala Phe Leu Arg Gln Glu Ser Phe Thr Lys Glu 805 810 815 Pro Ala Ser Gly Pro Pro Ala Pro Gly Lys Pro Pro His Ile Ser Ser 820 825 830 His Pro Leu Leu Gln Asp Leu Ala Ala Thr Arg Ala Ala Arg Met Asp 835 840 845 Phe His Ser Gln Asp Thr His Leu Ile Leu Lys Glu Thr Glu Thr Ala 850 855 860 Leu Ala Ala Leu Glu Ala Arg Leu Leu Ser Asn Ser Val Asp Ala Glu 865 870 875 880 Cys Glu Gly Gly Ser Thr Pro Arg Pro Pro Glu Asp Ala Leu Ser Gly 885 890 895 Asp Ser Asp Val Asp Thr Ala Ser Thr Val Ser Leu Arg Ser Gly Lys 900 905 910 Ser Gly Pro Ser Pro Thr Thr Pro Gln Pro Leu Arg Ala Gln Lys Glu 915 920 925 Met Ser Pro Ser Pro Pro Ala Ala Gln Asp Pro Gly Gly Thr Ala Leu 930 935 940 Val Ser Ala Arg Glu Gln Ser Ser Glu Arg Gln His His Pro Leu Gly 945 950 955 960 Pro Thr Asp Met Gly Arg Gly Glu Pro Val Arg Arg Ser Ala Ile Arg 965 970 975 Arg Gly His Arg Pro Arg Gly Ser Leu Asp Trp Pro Ser Glu Glu Arg 980 985 990 Gly Pro Val Leu Ala His Leu Pro Ser Ser Asp Val Met Ala Ser Asn 995 1000 1005 His Glu Thr Pro Glu Ala Thr Gly Ala Gly Arg Leu Gly Ser Arg Arg 1010 1015 1020 Lys Pro Ala Ala Pro Pro Pro Ser Pro Ala Ala Arg Glu Glu Gln Ser 1025 1030 1035 1040 Arg Ser Ser Ala Ser Ser Gln Lys Gly Pro Gln Ala Leu Thr Arg Ser 1045 1050 1055 Asn Ser Leu Ser Thr Pro Arg Pro Thr Arg Ala Ser Arg Leu Arg Arg 1060 1065 1070 Ala Arg Leu Gly Asp Ala Ser Asp Thr Glu Ala Ala Asp Gly Glu Arg 1075 1080 1085 Gly Ser Leu Gly Asn Pro Glu Pro Val Gly Arg Pro Ala Ala Glu Gln 1090 1095 1100 Ala Lys Lys Leu Ser Arg Leu Asp Ile Leu Ala Met Pro Arg Lys Arg 1105 1110 1115 1120 Ala Gly Ser Phe Thr Gly Thr Ser Asp Pro Glu Ala Ala Pro Ala Arg 1125 1130 1135 Thr Ser Phe Ser Gly Arg Ser Val Glu Leu Cys Cys Ala Ser Arg Lys

1140 1145 1150 Pro Thr Met Ala Glu Ala Arg Ala Val Ser Arg Lys Ala Ala Asn Thr 1155 1160 1165 Ala Thr Thr Thr Gly Pro Arg Gln Pro Phe Ser Arg Ala Arg Ser Gly 1170 1175 1180 Ser Ala Arg Tyr Thr Ser Thr Thr Gln Thr Pro Arg Ala Gly Ser Ser 1185 1190 1195 1200 Ser Arg Ala Arg Ser Arg Ala Pro Gly Pro Arg Asp Thr Asp Asp Asp 1205 1210 1215 Glu Glu Glu Pro Asp Pro Tyr Gly Phe Ile Val Gln Thr Ala Glu Ile 1220 1225 1230 Ala Glu Ile Ala Arg Leu Ser Gln Thr Leu Val Lys Asp Val Ala Ile 1235 1240 1245 Leu Ala Gln Glu Ile His Asp Val Ala Gly Asp Gly Asp Thr Leu Gly 1250 1255 1260 Ser Ser Glu Pro Ala His Ser Ala Ser Leu Ser Asn Met Pro Ser Thr 1265 1270 1275 1280 Pro Ala Ser Thr Ile Ser Ala Arg Glu Glu Leu Val Gln Arg Ile Pro 1285 1290 1295 Glu Ala Ser Leu Asn Phe Gln Lys Val Pro Pro Gly Ser Leu Asn Ser 1300 1305 1310 Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu Asp Ala Leu Ala 1315 1320 1325 Asn Lys Thr Arg Pro Arg Asn Arg Glu Glu Val Ile Phe Asp Asn Leu 1330 1335 1340 Met Leu Asn Pro Val Ser Gln Leu Ser Gln Ala Ile Arg Glu Asn Thr 1345 1350 1355 1360 Glu His Leu Ala Glu Lys Met Lys Ile Leu Phe Gln Asn Thr Gly Arg 1365 1370 1375 Ala Trp Glu Asp Leu Glu Ala Arg Ile Asn Ala Glu Asn Glu Val Pro 1380 1385 1390 Ile Leu Lys Thr Ser Asn Lys Glu Ile Ser Ser Ile Leu Lys Glu Leu 1395 1400 1405 Arg Arg Val Gln Lys Gln Leu Glu Val Ile Asn Ala Ile Val Asp Pro 1410 1415 1420 Ser Gly Ser Leu Asp Leu Leu Thr Gly Asn Arg Ser Leu Ala Ser Ser 1425 1430 1435 1440 Ala Gln Pro Gly Leu Gly Lys Gly Arg Val Ala Ala Gln Ser Pro Pro 1445 1450 1455 Ser Pro Ala Ser Ala Glu Ala Leu Leu Pro Ala Leu Pro Leu Arg Asn 1460 1465 1470 Phe Pro Gln Arg Ala Ser Cys Gly Pro Pro Ser Leu Pro Asp Pro Thr 1475 1480 1485 Phe Leu Pro Asp Ala Glu Arg Phe Leu Ile 1490 1495 <210 > SEQ ID NO 97 <211> LENGTH: 622 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 97 Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 1 5 10 15 Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 20 25 30 Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 35 40 45 Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 50 55 60 Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 65 70 75 80 Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 85 90 95 Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 100 105 110 Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 115 120 125 Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 130 135 140 Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 145 150 155 160 Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 165 170 175 Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 180 185 190 Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 195 200 205 Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 210 215 220 Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 225 230 235 240 His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 245 250 255 Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 260 265 270 Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 275 280 285 Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 290 295 300 Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 305 310 315 320 Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 325 330 335 Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 340 345 350 Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 355 360 365 Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 370 375 380 Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 385 390 395 400 Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 405 410 415 Glu Lys Leu Ser Ala Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 420 425 430 Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 435 440 445 Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 450 455 460 Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 465 470 475 480 Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 485 490 495 Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 500 505 510 Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 515 520 525 Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 530 535 540 Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 545 550 555 560 Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 565 570 575 Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 580 585 590 Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 595 600 605 Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 610 615 620 <210> SEQ ID NO 98 <211> LENGTH: 568 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 98 Met Ala Ser Ser Cys Ala Val Gln Val Lys Leu Glu Leu Gly His Arg 1 5 10 15 Ala Gln Val Arg Lys Lys Pro Thr Val Glu Gly Phe Thr His Asp Trp 20 25 30 Met Val Phe Val Arg Gly Pro Glu His Ser Asn Ile Gln His Phe Val 35 40 45 Glu Lys Val Val Phe His Leu His Glu Ser Phe Pro Arg Pro Lys Arg 50 55 60 Val Cys Lys Asp Pro Pro Tyr Lys Val Glu Glu Ser Gly Tyr Ala Gly 65 70 75 80 Phe Ile Leu Pro Ile Glu Val Tyr Phe Lys Asn Lys Glu Glu Pro Arg 85 90 95 Lys Val Arg Phe Asp Tyr Asp Leu Phe Leu His Leu Glu Gly His Pro 100 105 110 Pro Val Asn His Leu Arg Cys Glu Lys Leu Thr Phe Asn Asn Pro Thr 115 120 125 Glu Asp Phe Arg Arg Lys Leu Leu Lys Ala Gly Gly Asp Pro Asn Arg 130 135 140 Ser Ile His Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 145 150 155 160 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 165 170 175 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser 180 185 190 Phe Ser Lys Pro His Lys Leu Met Lys Glu His Lys Glu Lys Pro Ser 195 200 205 Lys Asp Ser Arg Glu His Lys Ser Ala Phe Lys Glu Pro Ser Arg Asp 210 215 220 His Asn Lys Ser Ser Lys Glu Ser Ser Lys Lys Pro Lys Glu Asn Lys 225 230 235 240 Pro Leu Lys Glu Glu Lys Ile Val Pro Lys Met Ala Phe Lys Glu Pro 245 250 255 Lys Pro Met Ser Lys Glu Pro Lys Pro Asp Ser Asn Leu Leu Thr Ile 260 265 270

Thr Ser Gly Gln Asp Lys Lys Ala Pro Ser Lys Arg Pro Pro Ile Ser 275 280 285 Asp Ser Glu Glu Leu Ser Ala Lys Lys Arg Lys Lys Ser Ser Ser Glu 290 295 300 Ala Leu Phe Lys Ser Phe Ser Ser Ala Pro Pro Leu Ile Leu Thr Cys 305 310 315 320 Ser Ala Asp Lys Lys Gln Ile Lys Asp Lys Ser His Val Lys Met Gly 325 330 335 Lys Val Lys Ile Glu Ser Glu Thr Ser Glu Lys Lys Lys Ser Thr Leu 340 345 350 Pro Pro Phe Asp Asp Ile Val Asp Pro Asn Asp Ser Asp Val Glu Glu 355 360 365 Asn Ile Ser Ser Lys Ser Asp Ser Glu Gln Pro Ser Pro Ala Ser Ser 370 375 380 Ser Ser Ser Ser Ser Ser Ser Phe Thr Pro Ser Gln Thr Arg Gln Gln 385 390 395 400 Gly Pro Leu Arg Ser Ile Met Lys Asp Leu His Ser Asp Asp Asn Glu 405 410 415 Glu Glu Ser Asp Glu Val Glu Asp Asn Asp Asn Asp Ser Glu Met Glu 420 425 430 Arg Pro Val Asn Arg Gly Gly Ser Arg Ser Arg Arg Val Ser Leu Ser 435 440 445 Asp Gly Ser Asp Ser Glu Ser Ser Ser Ala Ser Ser Pro Leu His His 450 455 460 Glu Pro Pro Pro Pro Leu Leu Lys Thr Asn Asn Asn Gln Ile Leu Glu 465 470 475 480 Val Lys Ser Pro Ile Lys Gln Ser Lys Ser Asp Lys Gln Ile Lys Asn 485 490 495 Gly Glu Cys Asp Lys Ala Tyr Leu Asp Glu Leu Val Glu Leu His Arg 500 505 510 Arg Leu Met Thr Leu Arg Glu Arg His Ile Leu Gln Gln Ile Val Asn 515 520 525 Leu Ile Glu Glu Thr Gly His Phe His Ile Thr Asn Thr Thr Phe Asp 530 535 540 Phe Asp Leu Cys Ser Leu Asp Lys Thr Thr Val Arg Lys Leu Gln Ser 545 550 555 560 Tyr Leu Glu Thr Ser Gly Thr Ser 565 <210> SEQ ID NO 99 <211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 99 Met Leu Leu Gly Leu Ala Ala Met Glu Leu Lys Val Trp Val Asp Gly 1 5 10 15 Ile Gln Arg Val Val Cys Gly Val Ser Glu Gln Thr Thr Cys Gln Glu 20 25 30 Val Val Ile Ala Leu Ala Gln Ala Ile Gly Gln Thr Gly Arg Phe Val 35 40 45 Leu Val Gln Arg Leu Arg Glu Lys Glu Arg Gln Leu Leu Pro Gln Glu 50 55 60 Cys Pro Val Gly Ala Gln Ala Thr Cys Gly Gln Phe Ala Ser Asp Val 65 70 75 80 Gln Phe Val Leu Arg Arg Thr Gly Pro Ser Leu Ala Gly Arg Pro Ser 85 90 95 Ser Asp Ser Cys Pro Pro Pro Glu Arg Cys Leu Ile Arg Ala Ser Leu 100 105 110 Pro Val Lys Pro Arg Ala Ala Leu Gly Cys Glu Pro Arg Lys Thr Leu 115 120 125 Thr Pro Glu Pro Ala Pro Ser Leu Ser Arg Pro Gly Pro Ala Ala Pro 130 135 140 Val Thr Pro Thr Pro Gly Cys Cys Thr Asp Leu Arg Gly Leu Glu Leu 145 150 155 160 Arg Val Gln Arg Asn Ala Glu Glu Leu Gly His Glu Ala Phe Trp Glu 165 170 175 Gln Glu Leu Arg Arg Glu Gln Ala Arg Glu Arg Glu Gly Gln Ala Arg 180 185 190 Leu Gln Ala Leu Ser Ala Ala Thr Ala Glu His Ala Ala Arg Leu Gln 195 200 205 Ala Leu Asp Ala Gln Ala Arg Ala Leu Glu Ala Glu Leu Gln Leu Ala 210 215 220 Ala Glu Ala Pro Gly Pro Pro Ser Pro Met Ala Ser Ala Thr Glu Arg 225 230 235 240 Leu His Gln Asp Leu Ala Val Gln Glu Arg Gln Ser Ala Glu Val Gln 245 250 255 Gly Ser Leu Ala Leu Val Ser Arg Ala Leu Glu Ala Ala Glu Arg Ala 260 265 270 Leu Gln Ala Gln Ala Gln Glu Leu Glu Glu Leu Asn Arg Glu Leu Arg 275 280 285 Gln Cys Asn Leu Gln Gln Phe Ile Gln Gln Thr Gly Ala Ala Leu Pro 290 295 300 Pro Pro Pro Arg Pro Asp Arg Gly Pro Pro Gly Thr Gln Gly Pro Leu 305 310 315 320 Pro Pro Ala Arg Glu Glu Ser Leu Leu Gly Ala Pro Ser Glu Ser His 325 330 335 Ala Gly Ala Gln Pro Arg Pro Arg Gly Gly Pro His Asp Ala Glu Leu 340 345 350 Leu Glu Val Ala Ala Ala Pro Ala Pro Glu Trp Cys Pro Leu Ala Ala 355 360 365 Gln Pro Gln Ala Leu 370 <210> SEQ ID NO 100 <211> LENGTH: 334 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 100 Met Lys Pro Pro Pro Arg Arg Arg Ala Ala Pro Ala Arg Tyr Leu Gly 1 5 10 15 Glu Val Thr Gly Pro Ala Thr Trp Ser Ala Arg Glu Lys Arg Gln Leu 20 25 30 Val Arg Leu Leu Gln Ala Arg Gln Gly Gln Pro Glu Pro Asp Ala Thr 35 40 45 Glu Leu Ala Arg Glu Leu Arg Gly Arg Ser Glu Ala Glu Ile Arg Val 50 55 60 Phe Leu Gln Gln Leu Lys Gly Arg Val Ala Arg Glu Ala Ile Gln Lys 65 70 75 80 Val His Pro Gly Gly Leu Gln Gly Pro Arg Arg Arg Glu Ala Gln Pro 85 90 95 Pro Ala Pro Ile Glu Val Trp Thr Asp Leu Ala Glu Lys Ile Thr Gly 100 105 110 Pro Leu Glu Glu Ala Leu Ala Val Ala Phe Ser Gln Val Leu Thr Ile 115 120 125 Ala Ala Thr Glu Pro Val Thr Leu Leu His Ser Lys Pro Pro Lys Pro 130 135 140 Thr Gln Ala Arg Gly Lys Pro Leu Leu Leu Ser Ala Pro Gly Gly Gln 145 150 155 160 Glu Asp Pro Ala Pro Glu Ile Pro Ser Ser Ala Pro Ala Ala Pro Ser 165 170 175 Ser Ala Pro Arg Thr Pro Asp Pro Ala Pro Glu Lys Pro Ser Glu Ser 180 185 190 Ser Ala Gly Pro Ser Thr Glu Glu Asp Phe Ala Val Asp Phe Glu Lys 195 200 205 Ile Tyr Lys Tyr Leu Ser Ser Val Ser Arg Ser Gly Arg Ser Pro Glu 210 215 220 Leu Ser Ala Ala Glu Ser Ala Val Val Leu Asp Leu Leu Met Ser Leu 225 230 235 240 Pro Glu Glu Leu Pro Leu Leu Pro Cys Thr Ala Leu Val Glu His Met 245 250 255 Thr Glu Thr Tyr Leu Arg Leu Thr Ala Pro Gln Pro Ile Pro Ala Gly 260 265 270 Gly Ser Leu Gly Pro Ala Ala Glu Gly Asp Gly Ala Gly Ser Lys Ala 275 280 285 Pro Glu Glu Thr Pro Pro Ala Thr Glu Lys Ala Glu His Ser Glu Leu 290 295 300 Lys Ser Pro Trp Gln Ala Ala Gly Ile Cys Pro Leu Asn Pro Phe Leu 305 310 315 320 Val Pro Leu Glu Leu Leu Gly Arg Ala Ala Thr Pro Ala Arg 325 330 <210> SEQ ID NO 101 <211> LENGTH: 1233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 101 Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 1 5 10 15 Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 20 25 30 Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 35 40 45 Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 50 55 60 Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 65 70 75 80 Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 85 90 95 Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 100 105 110 Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 115 120 125 Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 130 135 140 Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 145 150 155 160 Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 165 170 175 Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile

180 185 190 Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 195 200 205 Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 210 215 220 Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 225 230 235 240 Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 245 250 255 Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 260 265 270 Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 275 280 285 Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 290 295 300 Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 305 310 315 320 Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 325 330 335 Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 340 345 350 Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 355 360 365 Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 370 375 380 Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 385 390 395 400 Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 405 410 415 Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 420 425 430 Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 435 440 445 Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 450 455 460 Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 465 470 475 480 Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 485 490 495 Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 500 505 510 Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 515 520 525 Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 530 535 540 Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 545 550 555 560 Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 565 570 575 Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 580 585 590 Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 595 600 605 Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 610 615 620 Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 625 630 635 640 Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 645 650 655 Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 660 665 670 Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 675 680 685 Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 690 695 700 Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 705 710 715 720 Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 725 730 735 Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 740 745 750 Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 755 760 765 Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 770 775 780 Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 785 790 795 800 Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 805 810 815 Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 820 825 830 Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 835 840 845 Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 850 855 860 Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 865 870 875 880 Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 885 890 895 Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 900 905 910 Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 915 920 925 Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 930 935 940 Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 945 950 955 960 Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 965 970 975 Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 980 985 990 Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 995 1000 1005 Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 1010 1015 1020 Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 1025 1030 1035 1040 Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 1045 1050 1055 Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 1060 1065 1070 Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 1075 1080 1085 Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 1090 1095 1100 Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 1105 1110 1115 1120 Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 1125 1130 1135 Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 1140 1145 1150 Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 1155 1160 1165 Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 1170 1175 1180 Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 1185 1190 1195 1200 Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 1205 1210 1215 Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 1220 1225 1230 Gln <210> SEQ ID NO 102 <211> LENGTH: 749 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 102 Met Ala Arg Lys Leu Ser Val Ile Leu Ile Leu Thr Phe Ala Leu Ser 1 5 10 15 Val Thr Asn Pro Leu His Glu Leu Lys Ala Ala Ala Phe Pro Gln Thr 20 25 30 Thr Glu Lys Ile Ser Pro Asn Trp Glu Ser Gly Ile Asn Val Asp Leu 35 40 45 Ala Ile Ser Thr Arg Gln Tyr His Leu Gln Gln Leu Phe Tyr Arg Tyr 50 55 60 Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys Leu Leu Gln 65 70 75 80 Asn Ile Gly Ile Asp Lys Ile Lys Arg Ile His Ile His His Asp His 85 90 95 Asp His His Ser Asp His Glu His His Ser Asp His Glu Arg His Ser 100 105 110 Asp His Glu His His Ser Asp His Glu His His Ser Asp His Asn His 115 120 125 Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala Leu Cys Pro Asp His Asp 130 135 140 Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn Ser Gln Gly Lys Gly Ala 145 150 155 160 His Arg Pro Glu His Ala Ser Gly Arg Arg Asn Val Lys Asp Ser Val 165 170 175 Ser Ala Ser Glu Val Thr Ser Thr Val Tyr Asn Thr Val Ser Glu Gly 180 185 190 Thr His Phe Leu Glu Thr Ile Glu Thr Pro Arg Pro Gly Lys Leu Phe 195 200 205 Pro Lys Asp Val Ser Ser Ser Thr Pro Pro Ser Val Thr Ser Lys Ser 210 215 220 Arg Val Ser Arg Leu Ala Gly Arg Lys Thr Asn Glu Ser Val Ser Glu 225 230 235 240

Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn Thr Asn Glu Asn Pro Gln 245 250 255 Glu Cys Phe Asn Ala Ser Lys Leu Leu Thr Ser His Gly Met Gly Ile 260 265 270 Gln Val Pro Leu Asn Ala Thr Glu Phe Asn Tyr Leu Cys Pro Ala Ile 275 280 285 Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu Ile His Thr Ser Glu Lys 290 295 300 Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser Leu Gln Ile Ala Trp Val 305 310 315 320 Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser Phe Leu Ser Leu Leu Gly 325 330 335 Val Ile Leu Val Pro Leu Met Asn Arg Val Phe Phe Lys Phe Leu Leu 340 345 350 Ser Phe Leu Val Ala Leu Ala Val Gly Thr Leu Ser Gly Asp Ala Phe 355 360 365 Leu His Leu Leu Pro His Ser His Ala Ser His His His Ser His Ser 370 375 380 His Glu Glu Pro Ala Met Glu Met Lys Arg Gly Pro Leu Phe Ser His 385 390 395 400 Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala Tyr Phe Asp Ser Thr Trp 405 410 415 Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr Phe Met Phe Leu Val Glu 420 425 430 His Val Leu Thr Leu Ile Lys Gln Phe Lys Asp Lys Lys Lys Lys Asn 435 440 445 Gln Lys Lys Pro Glu Asn Asp Asp Asp Val Glu Ile Lys Lys Gln Leu 450 455 460 Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn Glu Glu Lys Val Asp Thr 465 470 475 480 Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala Asp Ser Gln Glu Pro Ser 485 490 495 His Phe Asp Ser Gln Gln Pro Ala Val Leu Glu Glu Glu Glu Val Met 500 505 510 Ile Ala His Ala His Pro Gln Glu Val Tyr Asn Glu Tyr Val Pro Arg 515 520 525 Gly Cys Lys Asn Lys Cys His Ser His Phe His Asp Thr Leu Gly Gln 530 535 540 Ser Asp Asp Leu Ile His His His His Asp Tyr His His Ile Leu His 545 550 555 560 His His His His Gln Asn His His Pro His Ser His Ser Gln Arg Tyr 565 570 575 Ser Arg Glu Glu Leu Lys Asp Ala Gly Val Ala Thr Leu Ala Trp Met 580 585 590 Val Ile Met Gly Asp Gly Leu His Asn Phe Ser Asp Gly Leu Ala Ile 595 600 605 Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser Gly Leu Ser Thr Ser Val 610 615 620 Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 625 630 635 640 Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Val Leu Tyr Asn Ala 645 650 655 Leu Ser Ala Met Leu Ala Tyr Leu Gly Met Ala Thr Gly Ile Phe Ile 660 665 670 Gly His Tyr Ala Glu Asn Val Ser Met Trp Ile Phe Ala Leu Thr Ala 675 680 685 Gly Leu Phe Met Tyr Val Ala Leu Val Asp Met Val Pro Glu Met Leu 690 695 700 His Asn Asp Ala Ser Asp His Gly Cys Ser Arg Trp Gly Tyr Phe Phe 705 710 715 720 Leu Gln Asn Ala Gly Met Leu Leu Gly Phe Gly Ile Met Leu Leu Ile 725 730 735 Ser Ile Phe Glu His Lys Ile Val Phe Arg Ile Asn Phe 740 745 <210> SEQ ID NO 103 <211> LENGTH: 519 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 103 Met Ile Pro Val Ser Leu Val Val Val Val Val Gly Gly Trp Thr Val 1 5 10 15 Val Tyr Leu Thr Asp Leu Val Leu Lys Ser Ser Val Tyr Phe Lys His 20 25 30 Ser Tyr Glu Asp Trp Leu Glu Asn Asn Gly Leu Ser Ile Ser Pro Phe 35 40 45 His Ile Arg Trp Gln Thr Ala Val Phe Asn Arg Ala Phe Tyr Ser Trp 50 55 60 Gly Arg Arg Lys Ala Arg Met Leu Tyr Gln Trp Phe Asn Phe Gly Met 65 70 75 80 Val Phe Gly Val Ile Ala Met Phe Ser Ser Phe Phe Leu Leu Gly Lys 85 90 95 Thr Leu Met Gln Thr Leu Ala Gln Met Met Ala Asp Ser Pro Ser Ser 100 105 110 Tyr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 115 120 125 Ser Ser Ser Ser Ser Ser Ser Ser Leu His Asn Glu Gln Val Leu Gln 130 135 140 Val Val Val Pro Gly Ile Asn Leu Pro Val Asn Gln Leu Thr Tyr Phe 145 150 155 160 Phe Thr Ala Val Leu Ile Ser Gly Val Val His Glu Ile Gly His Gly 165 170 175 Ile Ala Ala Ile Arg Glu Gln Val Arg Phe Asn Gly Phe Gly Ile Phe 180 185 190 Leu Phe Ile Ile Tyr Pro Gly Ala Phe Val Asp Leu Phe Thr Thr His 195 200 205 Leu Gln Leu Ile Ser Pro Val Gln Gln Leu Arg Ile Phe Cys Ala Gly 210 215 220 Ile Trp His Asn Phe Val Leu Ala Leu Leu Gly Ile Leu Ala Leu Val 225 230 235 240 Leu Leu Pro Val Ile Leu Leu Pro Phe Tyr Tyr Thr Gly Val Gly Val 245 250 255 Leu Ile Thr Glu Val Ala Glu Asp Ser Pro Ala Ile Gly Pro Arg Gly 260 265 270 Leu Phe Val Gly Asp Leu Val Thr His Leu Gln Asp Cys Pro Val Thr 275 280 285 Asn Val Gln Asp Trp Asn Glu Cys Leu Asp Thr Ile Ala Tyr Glu Pro 290 295 300 Gln Ile Gly Tyr Cys Ile Ser Ala Ser Thr Leu Gln Gln Leu Ser Phe 305 310 315 320 Pro Val Arg Ala Tyr Lys Arg Leu Asp Gly Ser Thr Glu Cys Cys Asn 325 330 335 Asn His Ser Leu Thr Asp Val Cys Phe Ser Tyr Arg Asn Asn Phe Asn 340 345 350 Lys Arg Leu His Thr Cys Leu Pro Ala Arg Lys Ala Val Glu Ala Thr 355 360 365 Gln Val Cys Arg Thr Asn Lys Asp Cys Lys Lys Ser Ser Ser Ser Ser 370 375 380 Phe Cys Ile Ile Pro Ser Leu Glu Thr His Thr Arg Leu Ile Lys Val 385 390 395 400 Lys His Pro Pro Gln Ile Asp Met Leu Tyr Val Gly His Pro Leu His 405 410 415 Leu His Tyr Thr Val Ser Ile Thr Ser Phe Ile Pro Arg Phe Asn Phe 420 425 430 Leu Ser Ile Asp Leu Pro Val Val Val Glu Thr Phe Val Lys Tyr Leu 435 440 445 Ile Ser Leu Ser Gly Ala Leu Ala Ile Val Asn Ala Val Pro Cys Phe 450 455 460 Ala Leu Asp Gly Gln Trp Ile Leu Asn Ser Phe Leu Asp Ala Thr Leu 465 470 475 480 Thr Ser Val Ile Gly Asp Asn Asp Val Lys Asp Leu Ile Gly Phe Phe 485 490 495 Ile Leu Leu Gly Gly Ser Val Leu Leu Ala Ala Asn Val Thr Leu Gly 500 505 510 Leu Trp Met Val Thr Ala Arg 515 <210> SEQ ID NO 104 <211> LENGTH: 274 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 104 Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 1 5 10 15 Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 20 25 30 Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 35 40 45 Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 50 55 60 Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 65 70 75 80 Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 85 90 95 Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 100 105 110 Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 115 120 125 Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 130 135 140 Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 145 150 155 160 Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 165 170 175 Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 180 185 190 Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 195 200 205

Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 210 215 220 Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 225 230 235 240 Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 245 250 255 Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 260 265 270 Gly Ser <210> SEQ ID NO 105 <211> LENGTH: 257 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 105 Met Ala Ala Asp Gly Val Asp Glu Arg Ser Pro Leu Leu Ser Ala Ser 1 5 10 15 His Ser Gly Asn Val Thr Pro Thr Ala Pro Pro Tyr Leu Gln Glu Ser 20 25 30 Ser Pro Arg Ala Glu Leu Pro Pro Pro Tyr Thr Ala Ile Ala Ser Pro 35 40 45 Asp Ala Ser Gly Ile Pro Val Ile Asn Cys Arg Val Cys Gln Ser Leu 50 55 60 Ile Asn Leu Asp Gly Lys Leu His Gln His Val Val Lys Cys Thr Val 65 70 75 80 Cys Asn Glu Ala Thr Pro Ile Lys Asn Pro Pro Thr Gly Lys Lys Tyr 85 90 95 Val Arg Cys Pro Cys Asn Cys Leu Leu Ile Cys Lys Asp Thr Ser Arg 100 105 110 Arg Ile Gly Cys Pro Arg Pro Asn Cys Arg Arg Ile Ile Asn Leu Gly 115 120 125 Pro Val Met Leu Ile Ser Glu Glu Gln Pro Ala Gln Pro Ala Leu Pro 130 135 140 Ile Gln Pro Glu Gly Thr Arg Val Val Cys Gly His Cys Gly Asn Thr 145 150 155 160 Phe Leu Trp Met Glu Leu Arg Phe Asn Thr Leu Ala Lys Cys Pro His 165 170 175 Cys Lys Lys Ile Ser Ser Val Gly Ser Ala Leu Pro Arg Arg Arg Cys 180 185 190 Cys Ala Tyr Ile Thr Ile Gly Met Ile Cys Ile Phe Ile Gly Val Gly 195 200 205 Leu Thr Val Gly Thr Pro Asp Phe Ala Arg Arg Phe Arg Ala Thr Tyr 210 215 220 Val Ser Trp Ala Ile Ala Tyr Leu Leu Gly Leu Ile Cys Leu Ile Arg 225 230 235 240 Ala Cys Tyr Trp Gly Ala Ile Arg Val Ser Tyr Pro Glu His Ser Phe 245 250 255 Ala <210> SEQ ID NO 106 <211> LENGTH: 619 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 106 Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn 1 5 10 15 Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp 20 25 30 Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr 35 40 45 Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly 50 55 60 Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu 65 70 75 80 Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu 85 90 95 Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr 100 105 110 Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly 115 120 125 Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp 130 135 140 Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr 145 150 155 160 Glu Ile Asp Met Lys Val Ile Gln Gln Arg Asn Glu Glu Cys Asp His 165 170 175 Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr 180 185 190 Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Glu Ser Arg Ile 195 200 205 Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp 210 215 220 Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu 225 230 235 240 Pro Gln Leu Gln Pro Gly Asn Cys Ser Leu Leu Ser Val Phe Ser Leu 245 250 255 Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile 260 265 270 Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu 275 280 285 Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Thr Glu Ile Ser Cys Leu 290 295 300 Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu 305 310 315 320 Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg 325 330 335 Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu 340 345 350 Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu 355 360 365 Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu 370 375 380 Asp Glu Lys Lys Lys Thr Asp Thr Leu Leu Tyr Ser Val Leu Pro Pro 385 390 395 400 Ser Val Ala Asn Glu Leu Arg His Lys Arg Pro Val Pro Ala Lys Arg 405 410 415 Tyr Asp Asn Val Thr Ile Leu Phe Ser Gly Ile Val Gly Phe Asn Ala 420 425 430 Phe Cys Ser Lys His Ala Ser Gly Glu Gly Ala Met Lys Ile Val Asn 435 440 445 Leu Leu Asn Asp Leu Tyr Thr Arg Phe Asp Thr Leu Thr Asp Ser Arg 450 455 460 Lys Asn Pro Phe Val Tyr Lys Val Glu Thr Val Gly Asp Lys Tyr Met 465 470 475 480 Thr Val Ser Gly Leu Pro Glu Pro Cys Ile His His Ala Arg Ser Ile 485 490 495 Cys His Leu Ala Leu Asp Met Met Glu Ile Ala Gly Gln Val Gln Val 500 505 510 Asp Gly Glu Ser Val Gln Ile Thr Ile Gly Ile His Thr Gly Glu Val 515 520 525 Val Thr Gly Val Ile Gly Gln Arg Met Pro Arg Tyr Cys Leu Phe Gly 530 535 540 Asn Thr Val Asn Leu Thr Ser Arg Thr Glu Thr Thr Gly Glu Lys Gly 545 550 555 560 Lys Ile Asn Val Ser Glu Tyr Thr Tyr Arg Cys Leu Met Ser Pro Glu 565 570 575 Asn Ser Asp Pro Gln Phe His Leu Glu His Arg Gly Pro Val Ser Met 580 585 590 Lys Gly Lys Lys Glu Pro Met Gln Val Trp Phe Leu Ser Arg Lys Asn 595 600 605 Thr Gly Thr Glu Glu Thr Lys Gln Asp Asp Asp 610 615 <210> SEQ ID NO 107 <211> LENGTH: 153 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 107 Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 1 5 10 15 Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 20 25 30 Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 35 40 45 Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 50 55 60 Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 65 70 75 80 Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 85 90 95 Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 100 105 110 Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 115 120 125 Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 130 135 140 Tyr Ala Val Ala Ile Lys Pro Cys Lys 145 150 <210> SEQ ID NO 108 <211> LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 108 Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 1 5 10 15 Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 20 25 30 Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 35 40 45

Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 50 55 60 Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 65 70 75 80 Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 85 90 95 Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 100 105 110 Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 115 120 125 Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 130 135 140 Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 145 150 155 160 Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 165 170 175 Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 180 185 190 Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 195 200 205 Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 210 215 220 Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 225 230 235 240 Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 245 250 <210> SEQ ID NO 109 <211> LENGTH: 518 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 109 Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 1 5 10 15 Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 20 25 30 Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 35 40 45 Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 50 55 60 Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 65 70 75 80 Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 85 90 95 Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 100 105 110 Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 115 120 125 Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 130 135 140 Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 145 150 155 160 Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 165 170 175 Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 180 185 190 Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 195 200 205 Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 210 215 220 Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 225 230 235 240 Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 245 250 255 Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 260 265 270 Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 275 280 285 Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 290 295 300 Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 305 310 315 320 Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 325 330 335 Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 340 345 350 Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 355 360 365 Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 370 375 380 Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 385 390 395 400 Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 405 410 415 Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 420 425 430 Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 435 440 445 Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 450 455 460 Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu Ser 465 470 475 480 Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln Gln 485 490 495 Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser Phe 500 505 510 Phe Tyr Leu Leu Tyr Ser 515 <210> SEQ ID NO 110 <211> LENGTH: 542 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 110 Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 1 5 10 15 Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 20 25 30 Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 35 40 45 Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 50 55 60 Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 65 70 75 80 Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 85 90 95 Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 100 105 110 Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 115 120 125 Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 130 135 140 Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 145 150 155 160 Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 165 170 175 Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 180 185 190 Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 195 200 205 Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 210 215 220 Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 225 230 235 240 Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 245 250 255 Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 260 265 270 Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 275 280 285 Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 290 295 300 Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 305 310 315 320 Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 325 330 335 Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 340 345 350 Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 355 360 365 Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 370 375 380 Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 385 390 395 400 Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 405 410 415 Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 420 425 430 Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 435 440 445 Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 450 455 460 Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 465 470 475 480 Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 485 490 495 Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 500 505 510

Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 515 520 525 Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 530 535 540 <210> SEQ ID NO 111 <211> LENGTH: 970 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 111 Met Ala Thr Cys Ile Gly Glu Lys Ile Glu Asp Phe Lys Val Gly Asn 1 5 10 15 Leu Leu Gly Lys Gly Ser Phe Ala Gly Val Tyr Arg Ala Glu Ser Ile 20 25 30 His Ser Gly Leu Glu Val Ala Ile Lys Met Ile Asp Lys Lys Ala Met 35 40 45 Tyr Lys Ala Gly Met Val Gln Arg Val Gln Asn Glu Val Lys Ile His 50 55 60 Cys Gln Leu Lys His Pro Ser Ile Leu Glu Leu Tyr Asn Tyr Phe Glu 65 70 75 80 Asp Ser Asn Tyr Val Tyr Leu Val Leu Glu Met Cys His Asn Gly Glu 85 90 95 Met Asn Arg Tyr Leu Lys Asn Arg Val Lys Pro Phe Ser Glu Asn Glu 100 105 110 Ala Arg His Phe Met His Gln Ile Ile Thr Gly Met Leu Tyr Leu His 115 120 125 Ser His Gly Ile Leu His Arg Asp Leu Thr Leu Ser Asn Leu Leu Leu 130 135 140 Thr Arg Asn Met Asn Ile Lys Ile Ala Asp Phe Gly Leu Ala Thr Gln 145 150 155 160 Leu Lys Met Pro His Glu Lys His Tyr Thr Leu Cys Gly Thr Pro Asn 165 170 175 Tyr Ile Ser Pro Glu Ile Ala Thr Arg Ser Ala His Gly Leu Glu Ser 180 185 190 Asp Val Trp Ser Leu Gly Cys Met Phe Tyr Thr Leu Leu Ile Gly Arg 195 200 205 Pro Pro Phe Asp Thr Asp Thr Val Lys Asn Thr Leu Asn Lys Val Val 210 215 220 Leu Ala Asp Tyr Glu Met Pro Thr Phe Leu Ser Ile Glu Ala Lys Asp 225 230 235 240 Leu Ile His Gln Leu Leu Arg Arg Asn Pro Ala Asp Arg Leu Ser Leu 245 250 255 Ser Ser Val Leu Asp His Pro Phe Met Ser Arg Asn Ser Ser Thr Lys 260 265 270 Ser Lys Asp Leu Gly Thr Val Glu Asp Ser Ile Asp Ser Gly His Ala 275 280 285 Thr Ile Ser Thr Ala Ile Thr Ala Ser Ser Ser Thr Ser Ile Ser Gly 290 295 300 Ser Leu Phe Asp Lys Arg Arg Leu Leu Ile Gly Gln Pro Leu Pro Asn 305 310 315 320 Lys Met Thr Val Phe Pro Lys Asn Lys Ser Ser Thr Asp Phe Ser Ser 325 330 335 Ser Gly Asp Gly Asn Ser Phe Tyr Thr Gln Trp Gly Asn Gln Glu Thr 340 345 350 Ser Asn Ser Gly Arg Gly Arg Val Ile Gln Asp Ala Glu Glu Arg Pro 355 360 365 His Ser Arg Tyr Leu Arg Arg Ala Tyr Ser Ser Asp Arg Ser Gly Thr 370 375 380 Ser Asn Arg Gln Ser Gln Ala Lys Thr Tyr Thr Met Glu Arg Cys His 385 390 395 400 Ser Ala Glu Met Leu Ser Val Ser Lys Arg Ser Gly Gly Gly Glu Asn 405 410 415 Glu Glu Arg Tyr Ser Pro Thr Asp Asn Asn Ala Asn Ile Phe Asn Phe 420 425 430 Phe Lys Glu Lys Thr Ser Ser Ser Ser Gly Ser Phe Glu Arg Pro Asp 435 440 445 Asn Asn Gln Ala Leu Ser Asn His Leu Cys Pro Gly Lys Thr Pro Phe 450 455 460 Pro Phe Ala Asp Pro Thr Pro Gln Thr Glu Thr Val Gln Gln Trp Phe 465 470 475 480 Gly Asn Leu Gln Ile Asn Ala His Leu Arg Lys Thr Thr Glu Tyr Asp 485 490 495 Ser Ile Ser Pro Asn Arg Asp Phe Gln Gly His Pro Asp Leu Gln Lys 500 505 510 Asp Thr Ser Lys Asn Ala Trp Thr Asp Thr Lys Val Lys Lys Asn Ser 515 520 525 Asp Ala Ser Asp Asn Ala His Ser Val Lys Gln Gln Asn Thr Met Lys 530 535 540 Tyr Met Thr Ala Leu His Ser Lys Pro Glu Ile Ile Gln Gln Glu Cys 545 550 555 560 Val Phe Gly Ser Asp Pro Leu Ser Glu Gln Ser Lys Thr Arg Gly Met 565 570 575 Glu Pro Pro Trp Gly Tyr Gln Asn Arg Thr Leu Arg Ser Ile Thr Ser 580 585 590 Pro Leu Val Ala His Arg Leu Lys Pro Ile Arg Gln Lys Thr Lys Lys 595 600 605 Ala Val Val Ser Ile Leu Asp Ser Glu Glu Val Cys Val Glu Leu Val 610 615 620 Lys Glu Tyr Ala Ser Gln Glu Tyr Val Lys Glu Val Leu Gln Ile Ser 625 630 635 640 Ser Asp Gly Asn Thr Ile Thr Ile Tyr Tyr Pro Asn Gly Gly Arg Gly 645 650 655 Phe Pro Leu Ala Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg 660 665 670 Tyr Ser Phe Asp Asn Leu Pro Glu Lys Tyr Trp Arg Lys Tyr Gln Tyr 675 680 685 Ala Ser Arg Phe Val Gln Leu Leu Arg Ser Lys Ser Pro Lys Ile Thr 690 695 700 Tyr Phe Thr Arg Tyr Ala Lys Cys Ile Leu Met Glu Asn Ser Pro Gly 705 710 715 720 Ala Asp Phe Glu Val Trp Phe Tyr Asp Gly Val Lys Ile His Lys Thr 725 730 735 Glu Asp Phe Ile Gln Val Ile Glu Lys Thr Gly Lys Ser Tyr Thr Leu 740 745 750 Lys Ser Glu Ser Glu Val Asn Ser Leu Lys Glu Glu Ile Lys Met Tyr 755 760 765 Met Asp His Ala Asn Glu Gly His Arg Ile Cys Leu Ala Leu Glu Ser 770 775 780 Ile Ile Ser Glu Glu Glu Arg Lys Thr Arg Ser Ala Pro Phe Phe Pro 785 790 795 800 Ile Ile Ile Gly Arg Lys Pro Gly Ser Thr Ser Ser Pro Lys Ala Leu 805 810 815 Ser Pro Pro Pro Ser Val Asp Ser Asn Tyr Pro Thr Arg Asp Arg Ala 820 825 830 Ser Phe Asn Arg Met Val Met His Ser Asp Ala Ser Pro Thr Gln Ala 835 840 845 Pro Ile Leu Asn Pro Ser Met Val Thr Asn Glu Gly Leu Gly Leu Thr 850 855 860 Thr Thr Ala Ser Gly Thr Asp Ile Ser Ser Asn Ser Leu Lys Asp Cys 865 870 875 880 Leu Pro Lys Ser Ala Gln Leu Leu Lys Ser Val Phe Val Lys Asn Val 885 890 895 Gly Trp Ala Thr Gln Leu Thr Ser Gly Ala Val Trp Val Gln Phe Asn 900 905 910 Asp Gly Ser Gln Leu Val Val Gln Ala Gly Val Ser Ser Ile Ser Tyr 915 920 925 Thr Ser Pro Asn Gly Gln Thr Thr Arg Tyr Gly Glu Asn Glu Lys Leu 930 935 940 Pro Asp Tyr Ile Lys Gln Lys Leu Gln Cys Leu Ser Ser Ile Leu Leu 945 950 955 960 Met Phe Ser Asn Pro Thr Pro Asn Phe His 965 970 <210> SEQ ID NO 112 <211> LENGTH: 345 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 112 Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 1 5 10 15 Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 20 25 30 Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 35 40 45 Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 50 55 60 His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 65 70 75 80 Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 85 90 95 Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 100 105 110 Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 115 120 125 Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 130 135 140 Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 145 150 155 160 Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 165 170 175 Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 180 185 190 Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 195 200 205 Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 210 215 220 Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 225 230 235 240 Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser

245 250 255 Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 260 265 270 Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 275 280 285 His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 290 295 300 Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 305 310 315 320 His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 325 330 335 Cys Val Cys Arg Gly Ser Thr Gly Gly 340 345 <210> SEQ ID NO 113 <211> LENGTH: 309 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 113 tgctttcttt ttatctgttt tggtaggaat aagcttttgt tctcttttct gttttgcaag 60 aacttcatca tataatgttt ctttcatgaa aagccagaag aagaggaaaa ttactgtaat 120 aactattgaa ggaataagaa caataaaata tgctgactca taaaactcca tggtactttt 180 gtcaatgtga tcctataaaa ccctgtgcgg ccgggaaagg agaccgggaa gacgcggcgg 240 cgccggcact acagcccggg ccgcccgctc cgaggcgccg ccgccgccgc cgccgccgcc 300 gcagtcgct 309 <210> SEQ ID NO 114 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (221)..(221) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (324)..(324) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 114 gccaagtgat aaagccacaa ccttgtgttt gctttccctc ccaatcccag aactcaggac 60 tggagcccat gtggtttgca gttaaaggcc aaaagtcctg cacctatttt ataaaactat 120 gactgtgttt atcactgtgt tggggtcggt tccatttttg aggttccatc tttatgaaaa 180 gataacctgt cttctaacct gcttggatgg ctggtagtca natgtgaacg aacacctacc 240 gtgtgcctgg ccatgttcta tgttctaggc tgcagcaatc aacaagatgg gccatacaac 300 acccacccgg tgaagttcaa gtcnagtagc tgttagctta aggaaagagt attcccttat 360 cccactacac cttaaaatgt attgctgtcc 390 <210> SEQ ID NO 115 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 115 tttttttttc caacagcaga tagattcttt atgttcaaga cagcaaattc agatacaaaa 60 acccaccgcc atcgtccctc cctccctcct gctctgggcc agggatgggc ctggaaggag 120 agatgggagg tggggaggag gttgcggggt tcacagcaga ctcgtgtcaa atgcggaggt 180 aacaggctcc acagggaggg ggctcctctc aggaggggtg agggcattat tgcatttgct 240 ggggggaagg acaaccctct cccctgtatt ccctgcgtca ggaaactagg aaggtcatga 300 cccccaaaca gaacccaagg ccccagggag acagagggac cagtttggca gctgatggtg 360 gaaagtggtg gaggcggggg tggccgccaa tttggctgat cctc 404 <210> SEQ ID NO 116 <211> LENGTH: 499 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 116 tttttttttt ttcctggggt gagaatcaaa ttcctgtgag ggggcattta gctcactgga 60 gtattcacga attaaaactt caatagcccc tttaatcatc tgatctctcc tctttgtttc 120 ttcatccaag gcttcttcat cgtcattagt gacagtttct ggccttgcat tcccattaga 180 agctttcttc tttgctttcc attcatccag ctgtgccttt gtctttgcat caactttaac 240 gagtagcttt ttctctccaa tttgcaggtc atgtaataat ctgagtgcac ggagggtaga 300 ttctggctcc ttgtactcac agaatccgaa ggcttgaagc tttccggaag caccttgtac 360 tctcttccag ctcaaaacca aaccacattt agctaagagt tgtcttataa gcatgtctga 420 agctttctcg gaaatgttgc caacaaaaac agtggtagta ggaccacaat tttcatcatt 480 ttctttagcc tttaagcct 499 <210> SEQ ID NO 117 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (335)..(335) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 117 ttttgtggtc taaaataaac ttttaattgc acatttgtgt cttgggttat ctgtggggtg 60 agaaacctcc tcacttccaa tcccagctat ctgggtacaa tctggtgttg tggtctggct 120 gtcggcgagg ggtagaggtg ggtgcaggac tggcccccga gtctgcaccg acctcttcag 180 ggcagggagc tcagaccatg gtagtacttg cactgcttca gggcctcgct gaagccctca 240 cacagggaca ggtcactctg agtggtggaa cagtccagga actgcctgat ctcataggcg 300 cagggcccca tctgcagggg ctggggggca gcggnggtgg gggcctgctg gacagcaggc 360 tgggagggct ccgagctccc cccgctgaag gctccggtca gggcgctgcc catgacgtgt 420 cccacagccg agcccacggc tacccctgcg gccgtggtcg ccatctgagc catgagcccc 480 ggctggcccg aag 493 <210> SEQ ID NO 118 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (484)..(484) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 118 gtcaaattgt atccgttaag ggttttctaa cttttgctat cccccccgcg accaaaaaaa 60 gggggggttt ataatttaaa gaaaaggaaa agaggcgtgg gttggtagtt gtgtccttaa 120 catttaggaa tgacatagcc tctggagtct acaaactgaa gaaactttca tctgatcagc 180 cttggaaatc caaagttaaa gagcctatgt gtctcttgag gcgggggtta gaggattcaa 240 atttgggatg atgctcattg attcctgacc atagcagtga gaggccattt tttgtgcagg 300 aaatgtgctt aggactcagt cttgttttcg gattatccac cacagaaacc ctgagacaca 360 gagcagctta gaagtctcta cccaggcgta aatagagctc cctactccag acccatagcc 420 agtgagaagg cccatttttt tggtgcagga aatgtgctta gggactcagt ccttggtttt 480 cgantatcca ccacaggaaa ccctggagac tag 513 <210> SEQ ID NO 119 <211> LENGTH: 415 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 119 tgctttctct tctctttcat gatatccttg gtgtcctgca gcatcttctc cttccaaaga 60 tcaaagaagt atgaagggtc tgtgtagaat ttgagtgcct cttttccatc gtccctgtaa 120 ggggtaagat tgttgagagg gggaggagta tcacaggtat tgtatgtttc taagacaggc 180 actgggagag agtttctgtc aaaaagcttc tggtcttgaa tggtggaact tctgaaggct 240 tttcgggtgt tgattccttg cagtgacact tcttcttcct tgggatccag ctgagtgact 300 ttaacctgta gtcggtcgac cctctcagca agggagctta cccgaggagc aaaggtattt 360 tcctgagtag aggactcccg aagaatgtct ctgcatattt actcaggctg ccgac 415 <210> SEQ ID NO 120 <211> LENGTH: 426 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 120 ttatgatttg gatgttttta aattattaat ttattttcaa atcatactca gtttgagttc 60 aaatagttca aaaatcaata taatgcttca ggatgcttcc agctattgaa acaacccaat 120 taaaaaatat acaactcaca ctttatttta gttaaattca taatgtaggt aatattaaaa 180 attattataa acatttaata atgctttata atttgctatt atagtacacc actacagaca 240 cataaaaagt tgacttatct aattaaaaca ttttcccttc ctatgtttct aattctgaaa 300 actataaaaa tattaaagtc atgttacata tttttcaaaa ataaaactgc catatcccat 360 tgccaacttt acatgaaaaa ggtatatgtt ctggtatatt aggaagttaa tgatgaaaaa 420 tatagg 426 <210> SEQ ID NO 121 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 121 tttttttttc tcttttaaaa acttttatta cgcattgcta aataacattg catgatgtat 60 tgcacacatc atgtggtaaa cagcactcca cagtaatcca tacaatagct cgtacaatga 120 ccatcaaaat agtttgaaaa ccgttatagt tttcatccga gtgagtgtct ttatattctt 180 ccatgcaatc tgatttcata attaagatta ctcttccatt ctacaacaac caaccgaaaa 240 taatttttta taaaagccca accacaacaa aaggtcattg ggacattacg aaaagtcgga 300 aattagactc caaaatatca caaggtgtcc gtcttttgaa agacttgtcc ctaaaatttg 360 tgtgatctga cacttgggtt gcttttaccg ccagcagcat gtgacactgt acttactgag 420 aaggaacagt acattgacat atcg 444 <210> SEQ ID NO 122 <211> LENGTH: 474

<212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (419)..(419) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (431)..(431) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (446)..(446) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (467)..(467) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 122 caattaaggg tgtacaaatt ataataatgc atctctatct tcatactttg aatggcaaac 60 gctatttatg cataaatatt ttcattttaa gtaatatatg aagtgtaaat actcgatata 120 taagtataga ttttaaagat atgggacttt attttcacat aagtcaatag atgtttctct 180 agaacaaaat atttagtaaa gctttataaa ttatattaaa aggaagcggg gaacatgtat 240 tttttaacat agaacagaag tgacttcatt ctttttagac atcagaaatg ttaaagttga 300 ttcccaatat ttgttgtact tttttgtagc aaatgttaaa aatcaccgag ttaccatgta 360 tagaatgtgg actgtcatgt tgatatcatt ggtacagtgg ataagcccat ttttaaccng 420 tatacatttc nccaatttaa ttaacngggg tgaataattt ggtttcnttt taga 474 <210> SEQ ID NO 123 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (419)..(419) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (431)..(431) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (446)..(446) <223> OTHER INFORMATION: n is a, c, g, or t <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (467)..(467) <223> OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 123 caattaaggg tgtacaaatt ataataatgc atctctatct tcatactttg aatggcaaac 60 gctatttatg cataaatatt ttcattttaa gtaatatatg aagtgtaaat actcgatata 120 taagtataga ttttaaagat atgggacttt attttcacat aagtcaatag atgtttctct 180 agaacaaaat atttagtaaa gctttataaa ttatattaaa aggaagcggg gaacatgtat 240 tttttaacat agaacagaag tgacttcatt ctttttagac atcagaaatg ttaaagttga 300 ttcccaatat ttgttgtact tttttgtagc aaatgttaaa aatcaccgag ttaccatgta 360 tagaatgtgg actgtcatgt tgatatcatt ggtacagtgg ataagcccat ttttaaccng 420 tatacatttc nccaatttaa ttaacngggg tgaataattt ggtttcnttt taga 474

Claims

1-81. (canceled)

82. A composition comprising at least 5 isolated nucleic acids, each of which hybridizes specifically under conditions of high stringency to part or all of a coding sequence whose expression is correlated with responsiveness of a rectal adenocarcinoma to radiochemotherapy.

83. The composition of claim 82, which comprises at least 5 isolated nucleic acids of at least about 15 contiguous nucleotides selected from nucleic acids that correspond to genes 1-54 from Table 3, and comprises no more than 9,000 total isolated nucleic acids.

84. The composition of claim 83, wherein the nucleic acids that correspond to genes 1-54 of Table 3 are selected from: (a) nucleic acids that comprise the sequences of SEQ ID NOs: 1-58 or 113-123; (b) nucleic acids that comprise sequences that are at least about 90% identical to the sequences of SEQ ID NOs: 1-58 or 113-123; (c) nucleic acids that comprise sequences encoding polypeptides represented by SEQ ID NOs: 59-112; (d) nucleic acids that comprise sequences of active fragments of the nucleic acids of (a), (b), or (c); (e) nucleic acids that comprise sequences of active variants of the nucleic acids of (a), (b), or (c) and/or (f) nucleic acids that comprise complete complements of the sequences of any of the nucleic acids (a)-(e); wherein the nucleic acids hybridize specifically under conditions of high stringency to nucleic acids represented by SEQ ID NOs: 1-58 or 113-123, or to complements thereof.

85. The composition of claim 83, wherein the at least 5 isolated nucleic acids correspond to genes 1-12 or 42-44 of Table 3.

86. The composition of claim 85, wherein the nucleic acids corresponding to genes 1-12 or 42-44 of Table 3 are selected from: (a) nucleic acids that comprise sequences comprising SEQ ID NOs: 1-15, 113-114, 46-48, or 120; (b) nucleic acids that comprise sequences that are at least about 90% identical to SEQ ID NOs: 1-15, 113-114, 46-48, or 120; (c) nucleic acids that comprise sequences encoding polypeptides represented by SEQ ID NOs 59-72 or 102-104; (d) nucleic acids that comprise sequences of active fragments of the nucleic acids of (a), (b), or (c); (e) nucleic acids that comprise sequences of active variants of the nucleic acids of (a), (b), or (c); and/or (f) nucleic acids that comprise complete complements of the sequences of any of the nucleic acids (a)-(e); wherein the nucleic acids hybridize specifically under conditions of high stringency to nucleic acids represented by SEQ ID NOs: 1-15, 113-114, 46-48 and 120, or to complements thereof.

87. A composition comprising at least 5 isolated, antigenic, polypeptides for use in generating antibodies for detecting the response of a rectal adenocarcinoma to radiochemotherapy, wherein the polypeptides are polypeptides whose expression is correlated with responsiveness of the adenocarcinoma to radiochemotherapy.

88. The composition of claim 87, wherein the at least 5 isolated, antigenic, polypeptides are selected from polypeptides that correspond to genes 1-54 from Table 3.

89. The composition of claim 88, wherein the composition comprises polypeptides selected from: (a) polypeptides comprising SEQ ID NOs: 59-112; (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-58 or 113-123; (c) polypeptides whose sequences are at least about 90% identical to SEQ ID NOs: 59-112; (d) active variants of (a), (b) or (c); and/or (e) antigenic fragments of (a), (b) or (c).

90. The composition of claim 88, wherein the polypeptides are selected from polypeptides corresponding to genes 1- 12 or 42-44 from Table 3.

91. The composition of claim 90, wherein the composition comprises polypeptides selected from: (a) polypeptides comprising SEQ ID NOs: 59-72 or 102-104; (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-15, 113-114, 46-48 or 120; (c) polypeptides that are at least about 90% identical to SEQ ID NOs: 59-72 or 102-104; (d) active variants of (a), (b), or (c); and/or (e) antigenic fragments of (a), (b), or (c).

92. A composition comprising at least 5 isolated antibodies, selected from antibodies that are specific for polypeptides corresponding to genes 1-54 of Table 3.

93. The composition of claim 92, wherein the antibodies are specific for polypeptides selected from: (a) polypeptides comprising SEQ ID NOs: 59-112; (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-58 or 113-123; (c) polypeptides whose sequences are at least about 90% identical to SEQ ID NOs: 59-112; (d) active variants of (a), (b) or (c); and/or (e) antigenic fragments of (a), (b) or (c).

94. The composition of claim 92, wherein the antibodies are specific for polypeptides selected from polypeptides corresponding to genes 1- 12 or 42-44 from Table 3.

95. The composition of claim 94, wherein the antibodies are specific for polypeptides selected from: (a) polypeptides comprising SEQ ID NOs: 59-72 or 102-104; (b) polypeptides encoded by polynucleotides comprising SEQ ID NOs: 1-15, 113-114, 46-48 or 120; (c) polypeptides that are at least about 90% identical to SEQ ID NOs: 59-72 or 102-104; (d) active variants of (a), (b), or (c); and/or (e) antigenic fragments of (a), (b), or (c).