U.S. patent application number 14/422574 was filed with the patent office on 2015-07-16 for fusion proteins and methods for treating, preventing or ameliorationg pain. The applicant listed for this patent is Allergan, Inc., Syntaxin Limited. Invention is credited to Roger Kei Aoki, John Chaddock, Keith Foster, Joseph Francis, Peter James, Lance Steward.
Application Number | 20150197739 14/422574 |
Document ID | / |
Family ID | 49123869 |
Filed Date | 2015-07-16 |
United States Patent Application | 20150197739 |
Kind Code | A1 |
James; Peter ; et al. | July 16, 2015 |
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which protease is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease and the galanin Targeting Moiety; a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site, wherein said first spacer comprises an amino acid sequence of from 4 to 25 amino acid residues; and a second spacer located between the galanin Targeting Moiety and the translocation domain, wherein said second spacer comprises an amino acid sequence of from 4 to 35 amino acid residues. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
Inventors: | James; Peter; (Abingdon, GB) ; Foster; Keith; (Abingdon, GB) ; Chaddock; John; (Abingdon, GB) ; Aoki; Roger Kei; (Irvine, CA) ; Steward; Lance; (Irvine, CA) ; Francis; Joseph; (Irvine, CA) | ||||||||||
Applicant: |
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Family ID: | 49123869 | ||||||||||
Appl. No.: | 14/422574 | ||||||||||
Filed: | August 27, 2013 | ||||||||||
PCT Filed: | August 27, 2013 | ||||||||||
PCT NO: | PCT/GB2013/052243 | ||||||||||
371 Date: | February 19, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13595927 | Aug 27, 2012 | |||
14422574 | ||||
Current U.S. Class: | 424/94.67 ; 435/220; 435/320.1; 536/23.2 |
Current CPC Class: | C12Y 304/21072 20130101; A61P 29/00 20180101; A61P 25/06 20180101; C12N 9/52 20130101; C07K 2319/50 20130101; C12Y 304/24068 20130101; A61K 47/65 20170801; C12N 15/625 20130101; C12Y 304/24069 20130101; A61K 47/64 20170801; C07K 2319/01 20130101; A61K 38/00 20130101; C07K 2319/55 20130101; C07K 2319/74 20130101; C12Y 304/24013 20130101; A61P 25/04 20180101; C07K 14/575 20130101 |
International Class: | C12N 9/52 20060101 C12N009/52; C07K 14/575 20060101 C07K014/575 |
Sequence CWU 1
1
5911302DNAArtificial SequenceSynthetic sequence 1ggatccatgg
agttcgttaa caaacagttc aactataaag acccagttaa cggtgttgac 60attgcttaca
tcaaaatccc gaacgctggc cagatgcagc cggtaaaggc attcaaaatc
120cacaacaaaa tctgggttat cccggaacgt gataccttta ctaacccgga
agaaggtgac 180ctgaacccgc caccggaagc gaaacaggtg ccggtatctt
actatgactc cacctacctg 240tctaccgata acgaaaagga caactacctg
aaaggtgtta ctaaactgtt cgagcgtatt 300tactccaccg acctgggccg
tatgctgctg actagcatcg ttcgcggtat cccgttctgg 360ggcggttcta
ccatcgatac cgaactgaaa gtaatcgaca ctaactgcat caacgttatt
420cagccggacg gttcctatcg ttccgaagaa ctgaacctgg tgatcatcgg
cccgtctgct 480gatatcatcc agttcgagtg taagagcttt ggtcacgaag
ttctgaacct cacccgtaac 540ggctacggtt ccactcagta catccgtttc
tctccggact tcaccttcgg ttttgaagaa 600tccctggaag tagacacgaa
cccactgctg ggcgctggta aattcgcaac tgatcctgcg 660gttaccctgg
ctcacgaact gattcatgca ggccaccgcc tgtacggtat cgccatcaat
720ccgaaccgtg tcttcaaagt taacaccaac gcgtattacg agatgtccgg
tctggaagtt 780agcttcgaag aactgcgtac ttttggcggt cacgacgcta
aattcatcga ctctctgcaa 840gaaaacgagt tccgtctgta ctactataac
aagttcaaag atatcgcatc caccctgaac 900aaagcgaaat ccatcgtggg
taccactgct tctctccagt acatgaagaa cgtttttaaa 960gaaaaatacc
tgctcagcga agacacctcc ggcaaattct ctgtagacaa gttgaaattc
1020gataaacttt acaaaatgct gactgaaatt tacaccgaag acaacttcgt
taagttcttt 1080aaagttctga accgcaaaac ctatctgaac ttcgacaagg
cagtattcaa aatcaacatc 1140gtgccgaaag ttaactacac tatctacgat
ggtttcaacc tgcgtaacac caacctggct 1200gctaatttta acggccagaa
cacggaaatc aacaacatga acttcacaaa actgaaaaac 1260ttcactggtc
tgttcgagtt ttacaagctg ctgtgcgtcg ac 130221257DNAArtificial
SequenceSynthetic 2ctgcagtgta tcaaggttaa caactgggat ttattcttca
gcccgagtga agacaacttc 60accaacgacc tgaacaaagg tgaagaaatc acctcagata
ctaacatcga agcagccgaa 120gaaaacatct cgctggacct gatccagcag
tactacctga cctttaattt cgacaacgag 180ccggaaaaca tttctatcga
aaacctgagc tctgatatca tcggccagct ggaactgatg 240ccgaacatcg
aacgtttccc aaacggtaaa aagtacgagc tggacaaata taccatgttc
300cactacctgc gcgcgcagga atttgaacac ggcaaatccc gtatcgcact
gactaactcc 360gttaacgaag ctctgctcaa cccgtcccgt gtatacacct
tcttctctag cgactacgtg 420aaaaaggtca acaaagcgac tgaagctgca
atgttcttgg gttgggttga acagcttgtt 480tatgatttta ccgacgagac
gtccgaagta tctactaccg acaaaattgc ggatatcact 540atcatcatcc
cgtacatcgg tccggctctg aacattggca acatgctgta caaagacgac
600ttcgttggcg cactgatctt ctccggtgcg gtgatcctgc tggagttcat
cccggaaatc 660gccatcccgg tactgggcac ctttgctctg gtttcttaca
ttgcaaacaa ggttctgact 720gtacaaacca tcgacaacgc gctgagcaaa
cgtaacgaaa aatgggatga agtttacaaa 780tatatcgtga ccaactggct
ggctaaggtt aatactcaga tcgacctcat ccgcaaaaaa 840atgaaagaag
cactggaaaa ccaggcggaa gctaccaagg caatcattaa ctaccagtac
900aaccagtaca ccgaggaaga aaaaaacaac atcaacttca acatcgacga
tctgtcctct 960aaactgaacg aatccatcaa caaagctatg atcaacatca
acaagttcct gaaccagtgc 1020tctgtaagct atctgatgaa ctccatgatc
ccgtacggtg ttaaacgtct ggaggacttc 1080gatgcgtctc tgaaagacgc
cctgctgaaa tacatttacg acaaccgtgg cactctgatc 1140ggtcaggttg
atcgtctgaa ggacaaagtg aacaatacct tatcgaccga catccctttt
1200cagctcagta aatatgtcga taaccaacgc cttttgtcca ctctagacta gaagctt
125731323DNAArtificial SequenceSynthetic 3ggatccatgc cggttaccat
caacaacttc aactacaacg acccgatcga caacaacaac 60atcattatga tggaaccgcc
gttcgcacgt ggtaccggac gttactacaa ggcttttaag 120atcaccgacc
gtatctggat catcccggaa cgttacacct tcggttacaa acctgaggac
180ttcaacaaga gtagcgggat tttcaatcgt gacgtctgcg agtactatga
tccagattat 240ctgaatacca acgataagaa gaacatattc cttcagacta
tgattaaact cttcaaccgt 300atcaaaagca aaccgctcgg tgaaaaactc
ctcgaaatga ttatcaacgg tatcccgtac 360ctcggtgacc gtcgtgtccc
gcttgaagag ttcaacacca acatcgcaag cgtcaccgtc 420aacaaactca
tcagcaaccc aggtgaagtc gaacgtaaaa aaggtatctt cgcaaacctc
480atcatcttcg gtccgggtcc ggtcctcaac gaaaacgaaa ccatcgacat
cggtatccag 540aaccacttcg caagccgtga aggtttcggt ggtatcatgc
agatgaaatt ctgcccggaa 600tacgtcagtg tcttcaacaa cgtccaggaa
aacaaaggtg caagcatctt caaccgtcgt 660ggttacttca gcgacccggc
actcatcctc atgcatgaac tcatccacgt cctccacggt 720ctctacggta
tcaaagttga cgacctcccg atcgtcccga acgagaagaa attcttcatg
780cagagcaccg acgcaatcca ggctgaggaa ctctacacct tcggtggcca
agacccaagt 840atcataaccc cgtccaccga caaaagcatc tacgacaaag
tcctccagaa cttcaggggt 900atcgtggaca gactcaacaa agtcctcgtc
tgcatcagcg acccgaacat caatatcaac 960atatacaaga acaagttcaa
agacaagtac aaattcgtcg aggacagcga aggcaaatac 1020agcatcgacg
tagaaagttt cgacaagctc tacaaaagcc tcatgttcgg tttcaccgaa
1080accaacatcg ccgagaacta caagatcaag acaagggcaa gttacttcag
cgacagcctc 1140ccgcctgtca aaatcaagaa cctcttagac aacgagattt
acacaattga agagggcttc 1200aacatcagtg acaaagacat ggagaaggaa
tacagaggtc agaacaaggc tatcaacaaa 1260caggcatacg aggagatcag
caaagaacac ctcgcagtct acaagatcca gatgtgcgtc 1320gac
132341260DNAArtificial SequenceSynthetic 4ctgcagtgca tcgacgttga
caacgaagac ctgttcttca tcgctgacaa aaacagcttc 60agtgacgacc tgagcaaaaa
cgaacgtatc gaatacaaca cccagagcaa ctacatcgaa 120aacgacttcc
cgatcaacga actgatcctg gacaccgacc tgataagtaa aatcgaactg
180ccgagcgaaa acaccgaaag tctgaccgac ttcaacgttg acgttccggt
ttacgaaaaa 240cagccggcta tcaagaaaat cttcaccgac gaaaacacca
tcttccagta cctgtacagc 300cagaccttcc cgctggacat ccgtgacatc
agtctgacca gcagtttcga cgacgctctg 360ctgttcagca acaaagttta
cagtttcttc agcatggact acatcaaaac cgctaacaaa 420gttgttgaag
cagggctgtt cgctggttgg gttaaacaga tcgttaacga cttcgttatc
480gaagctaaca aaagcaacac tatggacaaa atcgctgaca tcagtctgat
cgttccgtac 540atcggtctgg ctctgaacgt tggtaacgaa accgctaaag
gtaactttga aaacgctttc 600gagatcgctg gtgcaagcat cctgctggag
ttcatcccgg aactgctgat cccggttgtt 660ggtgctttcc tgctggaaag
ttacatcgac aacaaaaaca agatcatcaa aaccatcgac 720aacgctctga
ccaaacgtaa cgaaaaatgg agtgatatgt acggtctgat cgttgctcag
780tggctgagca ccgtcaacac ccagttctac accatcaaag aaggtatgta
caaagctctg 840aactaccagg ctcaggctct ggaagagatc atcaaatacc
gttacaacat ctacagtgag 900aaggaaaaga gtaacatcaa catcgacttc
aacgacatca acagcaaact gaacgaaggt 960atcaaccagg ctatcgacaa
catcaacaac ttcatcaacg gttgcagtgt tagctacctg 1020atgaagaaga
tgatcccgct ggctgttgaa aaactgctgg acttcgacaa caccctgaaa
1080aagaacctgc tgaactacat cgacgaaaac aagctgtacc tgatcggtag
tgctgaatac 1140gaaaaaagta aagtgaacaa atacctgaag accatcatgc
cgttcgacct gagtatctac 1200accaacgaca ccatcctgat cgaaatgttc
aacaaataca actctctaga ctagaagctt 126051329DNAArtificial
SequenceSynthetic 5ggatccgaat tcatgccgat caccatcaac aacttcaact
acagcgatcc ggtggataac 60aaaaacatcc tgtacctgga tacccatctg aataccctgg
cgaacgaacc ggaaaaagcg 120tttcgtatca ccggcaacat ttgggttatt
ccggatcgtt ttagccgtaa cagcaacccg 180aatctgaata aaccgccgcg
tgttaccagc ccgaaaagcg gttattacga tccgaactat 240ctgagcaccg
atagcgataa agataccttc ctgaaagaaa tcatcaaact gttcaaacgc
300atcaacagcc gtgaaattgg cgaagaactg atctatcgcc tgagcaccga
tattccgttt 360ccgggcaaca acaacacccc gatcaacacc tttgatttcg
atgtggattt caacagcgtt 420gatgttaaaa cccgccaggg taacaattgg
gtgaaaaccg gcagcattaa cccgagcgtg 480attattaccg gtccgcgcga
aaacattatt gatccggaaa ccagcacctt taaactgacc 540aacaacacct
ttgcggcgca ggaaggtttt ggcgcgctga gcattattag cattagcccg
600cgctttatgc tgacctatag caacgcgacc aacgatgttg gtgaaggccg
tttcagcaaa 660agcgaatttt gcatggaccc gatcctgatc ctgatgcatg
aactgaacca tgcgatgcat 720aacctgtatg gcatcgcgat tccgaacgat
cagaccatta gcagcgtgac cagcaacatc 780ttttacagcc agtacaacgt
gaaactggaa tatgcggaaa tctatgcgtt tggcggtccg 840accattgatc
tgattccgaa aagcgcgcgc aaatacttcg aagaaaaagc gctggattac
900tatcgcagca ttgcgaaacg tctgaacagc attaccaccg cgaatccgag
cagcttcaac 960aaatatatcg gcgaatataa acagaaactg atccgcaaat
atcgctttgt ggtggaaagc 1020agcggcgaag ttaccgttaa ccgcaataaa
ttcgtggaac tgtacaacga actgacccag 1080atcttcaccg aatttaacta
tgcgaaaatc tataacgtgc agaaccgtaa aatctacctg 1140agcaacgtgt
ataccccggt gaccgcgaat attctggatg ataacgtgta cgatatccag
1200aacggcttta acatcccgaa aagcaacctg aacgttctgt ttatgggcca
gaacctgagc 1260cgtaatccgg cgctgcgtaa agtgaacccg gaaaacatgc
tgtacctgtt caccaaattt 1320tgcgtcgac 132961263DNAArtificial
SequenceSynthetic 6ctgcagtgtc gtgaactgct ggtgaaaaac accgatctgc
cgtttattgg cgatatcagc 60gatgtgaaaa ccgatatctt cctgcgcaaa gatatcaacg
aagaaaccga agtgatctac 120tacccggata acgtgagcgt tgatcaggtg
atcctgagca aaaacaccag cgaacatggt 180cagctggatc tgctgtatcc
gagcattgat agcgaaagcg aaattctgcc gggcgaaaac 240caggtgtttt
acgataaccg tacccagaac gtggattacc tgaacagcta ttactacctg
300gaaagccaga aactgagcga taacgtggaa gattttacct ttacccgcag
cattgaagaa 360gcgctggata acagcgcgaa agtttacacc tattttccga
ccctggcgaa caaagttaat 420gcgggtgttc agggcggtct gtttctgatg
tgggcgaacg atgtggtgga agatttcacc 480accaacatcc tgcgtaaaga
taccctggat aaaatcagcg atgttagcgc gattattccg 540tatattggtc
cggcgctgaa cattagcaat agcgtgcgtc gtggcaattt taccgaagcg
600tttgcggtta ccggtgtgac cattctgctg gaagcgtttc cggaatttac
cattccggcg 660ctgggtgcgt ttgtgatcta tagcaaagtg caggaacgca
acgaaatcat caaaaccatc 720gataactgcc tggaacagcg tattaaacgc
tggaaagata gctatgaatg gatgatgggc 780acctggctga gccgtattat
cacccagttc aacaacatca gctaccagat gtacgatagc 840ctgaactatc
aggcgggtgc gattaaagcg aaaatcgatc tggaatacaa aaaatacagc
900ggcagcgata aagaaaacat caaaagccag gttgaaaacc tgaaaaacag
cctggatgtg 960aaaattagcg aagcgatgaa taacatcaac aaattcatcc
gcgaatgcag cgtgacctac 1020ctgttcaaaa acatgctgcc gaaagtgatc
gatgaactga acgaatttga tcgcaacacc 1080aaagcgaaac tgatcaacct
gatcgatagc cacaacatta ttctggtggg cgaagtggat 1140aaactgaaag
cgaaagttaa caacagcttc cagaacacca tcccgtttaa catcttcagc
1200tataccaaca acagcctgct gaaagatatc atcaacgaat acttcaatct
agactagaag 1260ctt 1263730PRTArtificial SequenceSynthetic sequence
7Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 1
5 10 15 Gly Asn His Arg Ser Phe Ser Asp Leu Asn Gly Leu Thr Ser 20
25 30 816PRTArtificial SequenceSynthetic sequence 8Gly Trp Thr Leu
Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 1 5 10 15
92781DNAArtificial SequenceSynthetic sequence 9atttcagaat
tcggatccat ggagttcgtt aacaaacagt tcaactataa agacccagtt 60aacggtgttg
acattgctta catcaaaatc ccgaacgctg gccagatgca gccggtaaag
120gcattcaaaa tccacaacaa aatctgggtt atcccggaac gtgatacctt
tactaacccg 180gaagaaggtg acctgaaccc gccaccggaa gcgaaacagg
tgccggtatc ttactatgac 240tccacctacc tgtctaccga taacgaaaag
gacaactacc tgaaaggtgt tactaaactg 300ttcgagcgta tttactccac
cgacctgggc cgtatgctgc tgactagcat cgttcgcggt 360atcccgttct
ggggcggttc taccatcgat accgaactga aagtaatcga cactaactgc
420atcaacgtta ttcagccgga cggttcctat cgttccgaag aactgaacct
ggtgatcatc 480ggcccgtctg ctgatatcat ccagttcgag tgtaagagct
ttggtcacga agttctgaac 540ctcacccgta acggctacgg ttccactcag
tacatccgtt tctctccgga cttcaccttc 600ggttttgaag aatccctgga
agtagacacg aacccactgc tgggcgctgg taaattcgca 660actgatcctg
cggttaccct ggctcacgaa ctgattcatg caggccaccg cctgtacggt
720atcgccatca atccgaaccg tgtcttcaaa gttaacacca acgcgtatta
cgagatgtcc 780ggtctggaag ttagcttcga agaactgcgt acttttggcg
gtcacgacgc taaattcatc 840gactctctgc aagaaaacga gttccgtctg
tactactata acaagttcaa agatatcgca 900tccaccctga acaaagcgaa
atccatcgtg ggtaccactg cttctctcca gtacatgaag 960aacgttttta
aagaaaaata cctgctcagc gaagacacct ccggcaaatt ctctgtagac
1020aagttgaaat tcgataaact ttacaaaatg ctgactgaaa tttacaccga
agacaacttc 1080gttaagttct ttaaagttct gaaccgcaaa acctatctga
acttcgacaa ggcagtattc 1140aaaatcaaca tcgtgccgaa agttaactac
actatctacg atggtttcaa cctgcgtaac 1200accaacctgg ctgctaattt
taacggccag aacacggaaa tcaacaacat gaacttcaca 1260aaactgaaaa
acttcactgg tctgttcgag ttttacaagc tgctgtgcgt cgacggcggt
1320ggcggtagcg gcggtggcgg tagcggcggt ggcggtagcg cagacgatga
cgataaaggt 1380tggaccctga actctgctgg ttacctgctg ggtccgcacg
ctgttgcgct agcgggcggt 1440ggcggtagcg gcggtggcgg tagcggcggt
ggcggtagcg cactagtgct gcagtgtatc 1500aaggttaaca actgggattt
attcttcagc ccgagtgaag acaacttcac caacgacctg 1560aacaaaggtg
aagaaatcac ctcagatact aacatcgaag cagccgaaga aaacatctcg
1620ctggacctga tccagcagta ctacctgacc tttaatttcg acaacgagcc
ggaaaacatt 1680tctatcgaaa acctgagctc tgatatcatc ggccagctgg
aactgatgcc gaacatcgaa 1740cgtttcccaa acggtaaaaa gtacgagctg
gacaaatata ccatgttcca ctacctgcgc 1800gcgcaggaat ttgaacacgg
caaatcccgt atcgcactga ctaactccgt taacgaagct 1860ctgctcaacc
cgtcccgtgt atacaccttc ttctctagcg actacgtgaa aaaggtcaac
1920aaagcgactg aagctgcaat gttcttgggt tgggttgaac agcttgttta
tgattttacc 1980gacgagacgt ccgaagtatc tactaccgac aaaattgcgg
atatcactat catcatcccg 2040tacatcggtc cggctctgaa cattggcaac
atgctgtaca aagacgactt cgttggcgca 2100ctgatcttct ccggtgcggt
gatcctgctg gagttcatcc cggaaatcgc catcccggta 2160ctgggcacct
ttgctctggt ttcttacatt gcaaacaagg ttctgactgt acaaaccatc
2220gacaacgcgc tgagcaaacg taacgaaaaa tgggatgaag tttacaaata
tatcgtgacc 2280aactggctgg ctaaggttaa tactcagatc gacctcatcc
gcaaaaaaat gaaagaagca 2340ctggaaaacc aggcggaagc taccaaggca
atcattaact accagtacaa ccagtacacc 2400gaggaagaaa aaaacaacat
caacttcaac atcgacgatc tgtcctctaa actgaacgaa 2460tccatcaaca
aagctatgat caacatcaac aagttcctga accagtgctc tgtaagctat
2520ctgatgaact ccatgatccc gtacggtgtt aaacgtctgg aggacttcga
tgcgtctctg 2580aaagacgccc tgctgaaata catttacgac aaccgtggca
ctctgatcgg tcaggttgat 2640cgtctgaagg acaaagtgaa caatacctta
tcgaccgaca tcccttttca gctcagtaaa 2700tatgtcgata accaacgcct
tttgtccact ctagaagcac tagcgagtgg gcaccatcac 2760catcaccatt
aatgaaagct t 278110923PRTArtificial SequenceSynthetic sequence
10Ile Ser Glu Phe Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr 1
5 10 15 Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn 20 25 30 Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile His
Asn Lys Ile 35 40 45 Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn
Pro Glu Glu Gly Asp 50 55 60 Leu Asn Pro Pro Pro Glu Ala Lys Gln
Val Pro Val Ser Tyr Tyr Asp 65 70 75 80 Ser Thr Tyr Leu Ser Thr Asp
Asn Glu Lys Asp Asn Tyr Leu Lys Gly 85 90 95 Val Thr Lys Leu Phe
Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met 100 105 110 Leu Leu Thr
Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr 115 120 125 Ile
Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile 130 135
140 Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile
145 150 155 160 Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser
Phe Gly His 165 170 175 Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly
Ser Thr Gln Tyr Ile 180 185 190 Arg Phe Ser Pro Asp Phe Thr Phe Gly
Phe Glu Glu Ser Leu Glu Val 195 200 205 Asp Thr Asn Pro Leu Leu Gly
Ala Gly Lys Phe Ala Thr Asp Pro Ala 210 215 220 Val Thr Leu Ala His
Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly 225 230 235 240 Ile Ala
Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr 245 250 255
Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe 260
265 270 Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu
Phe 275 280 285 Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser
Thr Leu Asn 290 295 300 Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser
Leu Gln Tyr Met Lys 305 310 315 320 Asn Val Phe Lys Glu Lys Tyr Leu
Leu Ser Glu Asp Thr Ser Gly Lys 325 330 335 Phe Ser Val Asp Lys Leu
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr 340 345 350 Glu Ile Tyr Thr
Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn 355 360 365 Arg Lys
Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile 370 375 380
Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn 385
390 395 400 Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile
Asn Asn 405 410 415 Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu
Phe Glu Phe Tyr 420 425 430 Lys Leu Leu Cys Val Asp Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 435 440 445 Gly Gly Gly Gly Ser Ala Asp Asp
Asp Asp Lys Gly Trp Thr Leu Asn 450 455 460 Ser Ala Gly Tyr Leu Leu
Gly Pro His Ala Val Ala Leu Ala Gly Gly 465 470 475 480 Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val 485 490 495 Leu
Gln Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser 500 505
510 Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser
515 520 525 Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp
Leu Ile 530 535 540 Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu
Pro Glu Asn Ile 545 550
555 560 Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu
Met 565 570 575 Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu
Leu Asp Lys 580 585 590 Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu
Phe Glu His Gly Lys 595 600 605 Ser Arg Ile Ala Leu Thr Asn Ser Val
Asn Glu Ala Leu Leu Asn Pro 610 615 620 Ser Arg Val Tyr Thr Phe Phe
Ser Ser Asp Tyr Val Lys Lys Val Asn 625 630 635 640 Lys Ala Thr Glu
Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val 645 650 655 Tyr Asp
Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile 660 665 670
Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 675
680 685 Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe
Ser 690 695 700 Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala
Ile Pro Val 705 710 715 720 Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile
Ala Asn Lys Val Leu Thr 725 730 735 Val Gln Thr Ile Asp Asn Ala Leu
Ser Lys Arg Asn Glu Lys Trp Asp 740 745 750 Glu Val Tyr Lys Tyr Ile
Val Thr Asn Trp Leu Ala Lys Val Asn Thr 755 760 765 Gln Ile Asp Leu
Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 770 775 780 Ala Glu
Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 785 790 795
800 Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser
805 810 815 Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn
Lys Phe 820 825 830 Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser
Met Ile Pro Tyr 835 840 845 Gly Val Lys Arg Leu Glu Asp Phe Asp Ala
Ser Leu Lys Asp Ala Leu 850 855 860 Leu Lys Tyr Ile Tyr Asp Asn Arg
Gly Thr Leu Ile Gly Gln Val Asp 865 870 875 880 Arg Leu Lys Asp Lys
Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe 885 890 895 Gln Leu Ser
Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Glu 900 905 910 Ala
Leu Ala Ser Gly His His His His His His 915 920 11912PRTArtificial
SequenceSynthetic sequence 11Ile Ser Glu Phe Gly Ser Met Glu Phe
Val Asn Lys Gln Phe Asn Tyr 1 5 10 15 Lys Asp Pro Val Asn Gly Val
Asp Ile Ala Tyr Ile Lys Ile Pro Asn 20 25 30 Ala Gly Gln Met Gln
Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile 35 40 45 Trp Val Ile
Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp 50 55 60 Leu
Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp 65 70
75 80 Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly 85 90 95 Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met 100 105 110 Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr 115 120 125 Ile Asp Thr Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile 130 135 140 Gln Pro Asp Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile 145 150 155 160 Gly Pro Ser Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His 165 170 175 Glu Val
Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile 180 185 190
Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val 195
200 205 Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala 210 215 220 Val Thr Leu Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly 225 230 235 240 Ile Ala Ile Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr 245 250 255 Tyr Glu Met Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe 260 265 270 Gly Gly His Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe 275 280 285 Arg Leu Tyr Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn 290 295 300 Lys Ala
Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys 305 310 315
320 Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
325 330 335 Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr 340 345 350 Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn 355 360 365 Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile 370 375 380 Val Pro Lys Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn 385 390 395 400 Thr Asn Leu Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn 405 410 415 Met Asn Phe
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr 420 425 430 Lys
Leu Leu Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 435 440
445 Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn
450 455 460 Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu Ala
Gly Gly 465 470 475 480 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Leu Val 485 490 495 Leu Gln Cys Ile Lys Val Asn Asn Trp
Asp Leu Phe Phe Ser Pro Ser 500 505 510 Glu Asp Asn Phe Thr Asn Asp
Leu Asn Lys Gly Glu Glu Ile Thr Ser 515 520 525 Asp Thr Asn Ile Glu
Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile 530 535 540 Gln Gln Tyr
Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile 545 550 555 560
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met 565
570 575 Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp
Lys 580 585 590 Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu
His Gly Lys 595 600 605 Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu Leu Asn Pro 610 615 620 Ser Arg Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys Lys Val Asn 625 630 635 640 Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu Gln Leu Val 645 650 655 Tyr Asp Phe Thr
Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile 660 665 670 Ala Asp
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 675 680 685
Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser 690
695 700 Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro
Val 705 710 715 720 Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys Val Leu Thr 725 730 735 Val Gln Thr Ile Asp Asn Ala Leu Ser Lys
Arg Asn Glu Lys Trp Asp 740 745 750 Glu Val Tyr Lys Tyr Ile Val Thr
Asn Trp Leu Ala Lys Val Asn Thr 755 760 765 Gln Ile Asp Leu Ile Arg
Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 770 775 780 Ala Glu Ala Thr
Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 785 790 795 800 Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser 805 810
815 Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe
820 825 830 Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile
Pro Tyr 835 840 845 Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu
Lys Asp Ala Leu 850 855 860 Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr
Leu Ile Gly Gln Val Asp 865 870 875 880 Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp Ile Pro Phe 885 890 895 Gln Leu Ser Lys Tyr
Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 900 905 910
122745DNAArtificial SequenceSynthetic sequence 12catatgggat
ccatggagtt cgttaacaaa cagttcaact ataaagaccc agttaacggt 60gttgacattg
cttacatcaa aatcccgaac gctggccaga tgcagccggt aaaggcattc
120aaaatccaca acaaaatctg ggttatcccg gaacgtgata cctttactaa
cccggaagaa 180ggtgacctga acccgccacc ggaagcgaaa caggtgccgg
tatcttacta tgactccacc 240tacctgtcta ccgataacga aaaggacaac
tacctgaaag gtgttactaa actgttcgag 300cgtatttact ccaccgacct
gggccgtatg ctgctgacta gcatcgttcg cggtatcccg 360ttctggggcg
gttctaccat cgataccgaa ctgaaagtaa tcgacactaa ctgcatcaac
420gttattcagc cggacggttc ctatcgttcc gaagaactga acctggtgat
catcggcccg 480tctgctgata tcatccagtt cgagtgtaag agctttggtc
acgaagttct gaacctcacc 540cgtaacggct acggttccac tcagtacatc
cgtttctctc cggacttcac cttcggtttt 600gaagaatccc tggaagtaga
cacgaaccca ctgctgggcg ctggtaaatt cgcaactgat 660cctgcggtta
ccctggctca cgaactgatt catgcaggcc accgcctgta cggtatcgcc
720atcaatccga accgtgtctt caaagttaac accaacgcgt attacgagat
gtccggtctg 780gaagttagct tcgaagaact gcgtactttt ggcggtcacg
acgctaaatt catcgactct 840ctgcaagaaa acgagttccg tctgtactac
tataacaagt tcaaagatat cgcatccacc 900ctgaacaaag cgaaatccat
cgtgggtacc actgcttctc tccagtacat gaagaacgtt 960tttaaagaaa
aatacctgct cagcgaagac acctccggca aattctctgt agacaagttg
1020aaattcgata aactttacaa aatgctgact gaaatttaca ccgaagacaa
cttcgttaag 1080ttctttaaag ttctgaaccg caaaacctat ctgaacttcg
acaaggcagt attcaaaatc 1140aacatcgtgc cgaaagttaa ctacactatc
tacgatggtt tcaacctgcg taacaccaac 1200ctggctgcta attttaacgg
ccagaacacg gaaatcaaca acatgaactt cacaaaactg 1260aaaaacttca
ctggtctgtt cgagttttac aagctgctgt gcgtcgacgg cggtggcggt
1320agcgcagacg atgacgataa aggttggacc ctgaactctg ctggttacct
gctgggtccg 1380cacgctgttg cgctagcggg cggtggcggt agcggcggtg
gcggtagcgg cggtggcggt 1440agcgcactag tgctgcagtg tatcaaggtt
aacaactggg atttattctt cagcccgagt 1500gaagacaact tcaccaacga
cctgaacaaa ggtgaagaaa tcacctcaga tactaacatc 1560gaagcagccg
aagaaaacat ctcgctggac ctgatccagc agtactacct gacctttaat
1620ttcgacaacg agccggaaaa catttctatc gaaaacctga gctctgatat
catcggccag 1680ctggaactga tgccgaacat cgaacgtttc ccaaacggta
aaaagtacga gctggacaaa 1740tataccatgt tccactacct gcgcgcgcag
gaatttgaac acggcaaatc ccgtatcgca 1800ctgactaact ccgttaacga
agctctgctc aacccgtccc gtgtatacac cttcttctct 1860agcgactacg
tgaaaaaggt caacaaagcg actgaagctg caatgttctt gggttgggtt
1920gaacagcttg tttatgattt taccgacgag acgtccgaag tatctactac
cgacaaaatt 1980gcggatatca ctatcatcat cccgtacatc ggtccggctc
tgaacattgg caacatgctg 2040tacaaagacg acttcgttgg cgcactgatc
ttctccggtg cggtgatcct gctggagttc 2100atcccggaaa tcgccatccc
ggtactgggc acctttgctc tggtttctta cattgcaaac 2160aaggttctga
ctgtacaaac catcgacaac gcgctgagca aacgtaacga aaaatgggat
2220gaagtttaca aatatatcgt gaccaactgg ctggctaagg ttaatactca
gatcgacctc 2280atccgcaaaa aaatgaaaga agcactggaa aaccaggcgg
aagctaccaa ggcaatcatt 2340aactaccagt acaaccagta caccgaggaa
gaaaaaaaca acatcaactt caacatcgac 2400gatctgtcct ctaaactgaa
cgaatccatc aacaaagcta tgatcaacat caacaagttc 2460ctgaaccagt
gctctgtaag ctatctgatg aactccatga tcccgtacgg tgttaaacgt
2520ctggaggact tcgatgcgtc tctgaaagac gccctgctga aatacattta
cgacaaccgt 2580ggcactctga tcggtcaggt tgatcgtctg aaggacaaag
tgaacaatac cttatcgacc 2640gacatccctt ttcagctcag taaatatgtc
gataaccaac gccttttgtc cactctagaa 2700gcactagcga gtgggcacca
tcaccatcac cattaatgaa agctt 274513910PRTArtificial
SequenceSynthetic sequence 13Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440
445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu
450 455 460 Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn
Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu Asp Asn Phe Thr Asn
Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr Ser Asp Thr Asn Ile
Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525 Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530 535 540 Glu Asn Ile
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 545 550 555 560
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 565
570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe
Glu
580 585 590 His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys Ala Thr Glu Ala Ala Met
Phe Leu Gly Trp Val Glu 625 630 635 640 Gln Leu Val Tyr Asp Phe Thr
Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650 655 Asp Lys Ile Ala Asp
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 660 665 670 Leu Asn Ile
Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 675 680 685 Ile
Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 690 695
700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys
705 710 715 720 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys
Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr
Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr Gln Ile Asp Leu Ile Arg
Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu Asn Gln Ala Glu Ala Thr
Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775 780 Gln Tyr Thr Glu Glu
Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 785 790 795 800 Leu Ser
Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 805 810 815
Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 820
825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu
Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr
Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn
Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro Phe Gln Leu Ser Lys Tyr
Val Asp Asn Gln Arg Leu Leu Ser 885 890 895 Thr Leu Glu Ala Leu Ala
Ser Gly His His His His His His 900 905 910 14899PRTArtificial
SequenceSynthetic sequence 14Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440
445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu
450 455 460 Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn
Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu Asp Asn Phe Thr Asn
Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr Ser Asp Thr Asn Ile
Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525 Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530 535 540 Glu Asn Ile
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 545 550 555 560
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 565
570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe
Glu 580 585 590 His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn
Glu Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser
Ser Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu 625 630 635 640 Gln Leu Val Tyr Asp Phe
Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650 655 Asp Lys Ile Ala
Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 660 665 670 Leu Asn
Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 675 680 685
Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 690
695 700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys 705 710 715 720 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser
Lys Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val
Thr Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu Asn Gln Ala Glu Ala
Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775 780 Gln Tyr Thr Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 785 790 795 800 Leu
Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 805 810
815 Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
820 825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro Phe Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser 885 890 895 Thr Leu Asp
152787DNAArtificial SequenceSynthetic sequence 15catatgggat
ccatggagtt cgttaacaaa cagttcaact ataaagaccc agttaacggt 60gttgacattg
cttacatcaa aatcccgaac gctggccaga tgcagccggt aaaggcattc
120aaaatccaca acaaaatctg ggttatcccg gaacgtgata cctttactaa
cccggaagaa 180ggtgacctga acccgccacc ggaagcgaaa caggtgccgg
tatcttacta tgactccacc 240tacctgtcta ccgataacga aaaggacaac
tacctgaaag gtgttactaa actgttcgag 300cgtatttact ccaccgacct
gggccgtatg ctgctgacta gcatcgttcg cggtatcccg 360ttctggggcg
gttctaccat cgataccgaa ctgaaagtaa tcgacactaa ctgcatcaac
420gttattcagc cggacggttc ctatcgttcc gaagaactga acctggtgat
catcggcccg 480tctgctgata tcatccagtt cgagtgtaag agctttggtc
acgaagttct gaacctcacc 540cgtaacggct acggttccac tcagtacatc
cgtttctctc cggacttcac cttcggtttt 600gaagaatccc tggaagtaga
cacgaaccca ctgctgggcg ctggtaaatt cgcaactgat 660cctgcggtta
ccctggctca cgaactgatt catgcaggcc accgcctgta cggtatcgcc
720atcaatccga accgtgtctt caaagttaac accaacgcgt attacgagat
gtccggtctg 780gaagttagct tcgaagaact gcgtactttt ggcggtcacg
acgctaaatt catcgactct 840ctgcaagaaa acgagttccg tctgtactac
tataacaagt tcaaagatat cgcatccacc 900ctgaacaaag cgaaatccat
cgtgggtacc actgcttctc tccagtacat gaagaacgtt 960tttaaagaaa
aatacctgct cagcgaagac acctccggca aattctctgt agacaagttg
1020aaattcgata aactttacaa aatgctgact gaaatttaca ccgaagacaa
cttcgttaag 1080ttctttaaag ttctgaaccg caaaacctat ctgaacttcg
acaaggcagt attcaaaatc 1140aacatcgtgc cgaaagttaa ctacactatc
tacgatggtt tcaacctgcg taacaccaac 1200ctggctgcta attttaacgg
ccagaacacg gaaatcaaca acatgaactt cacaaaactg 1260aaaaacttca
ctggtctgtt cgagttttac aagctgctgt gcgtcgacgg cggtggcggt
1320agcgcagacg atgacgataa aggttggacc ctgaactctg ctggttacct
gctgggtccg 1380cacgctgttg gtaaccaccg ttctttctct gacctgaacg
gtctgacctc tgcgctagcg 1440ggcggtggcg gtagcggcgg tggcggtagc
ggcggtggcg gtagcgcact agtgctgcag 1500tgtatcaagg ttaacaactg
ggatttattc ttcagcccga gtgaagacaa cttcaccaac 1560gacctgaaca
aaggtgaaga aatcacctca gatactaaca tcgaagcagc cgaagaaaac
1620atctcgctgg acctgatcca gcagtactac ctgaccttta atttcgacaa
cgagccggaa 1680aacatttcta tcgaaaacct gagctctgat atcatcggcc
agctggaact gatgccgaac 1740atcgaacgtt tcccaaacgg taaaaagtac
gagctggaca aatataccat gttccactac 1800ctgcgcgcgc aggaatttga
acacggcaaa tcccgtatcg cactgactaa ctccgttaac 1860gaagctctgc
tcaacccgtc ccgtgtatac accttcttct ctagcgacta cgtgaaaaag
1920gtcaacaaag cgactgaagc tgcaatgttc ttgggttggg ttgaacagct
tgtttatgat 1980tttaccgacg agacgtccga agtatctact accgacaaaa
ttgcggatat cactatcatc 2040atcccgtaca tcggtccggc tctgaacatt
ggcaacatgc tgtacaaaga cgacttcgtt 2100ggcgcactga tcttctccgg
tgcggtgatc ctgctggagt tcatcccgga aatcgccatc 2160ccggtactgg
gcacctttgc tctggtttct tacattgcaa acaaggttct gactgtacaa
2220accatcgaca acgcgctgag caaacgtaac gaaaaatggg atgaagttta
caaatatatc 2280gtgaccaact ggctggctaa ggttaatact cagatcgacc
tcatccgcaa aaaaatgaaa 2340gaagcactgg aaaaccaggc ggaagctacc
aaggcaatca ttaactacca gtacaaccag 2400tacaccgagg aagaaaaaaa
caacatcaac ttcaacatcg acgatctgtc ctctaaactg 2460aacgaatcca
tcaacaaagc tatgatcaac atcaacaagt tcctgaacca gtgctctgta
2520agctatctga tgaactccat gatcccgtac ggtgttaaac gtctggagga
cttcgatgcg 2580tctctgaaag acgccctgct gaaatacatt tacgacaacc
gtggcactct gatcggtcag 2640gttgatcgtc tgaaggacaa agtgaacaat
accttatcga ccgacatccc ttttcagctc 2700agtaaatatg tcgataacca
acgccttttg tccactctag aagcactagc gagtgggcac 2760catcaccatc
accattaatg aaagctt 278716924PRTArtificial SequenceSynthetic
sequence 16Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys
Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His
Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn
Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp
Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe
Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110
Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115
120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile
Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser
Phe Gly His Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly
Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly
Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His
Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235
240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met
245 250 255 Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly
Gly His 260 265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu
Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser
Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser
Leu Gln Tyr Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu
Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr
Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360
365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys
370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr
Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile
Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu
Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly
Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440 445 Thr Leu Asn Ser Ala
Gly Tyr Leu Leu Gly Pro His Ala Val Gly Asn 450 455 460 His Arg Ser
Phe Ser Asp Leu Asn Gly Leu Thr Ser Ala Leu Ala Gly 465 470 475 480
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 485
490 495 Val Leu Gln Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser
Pro 500 505 510 Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu
Glu Ile Thr 515 520 525 Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn
Ile Ser Leu Asp Leu 530 535 540 Ile Gln Gln Tyr Tyr Leu Thr Phe Asn
Phe Asp Asn Glu Pro Glu Asn 545 550 555 560 Ile Ser Ile Glu Asn Leu
Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 565 570 575 Met Pro Asn Ile
Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 580 585 590 Lys Tyr
Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 595 600 605
Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 610
615 620 Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys
Val 625 630
635 640 Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln
Leu 645 650 655 Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr
Thr Asp Lys 660 665 670 Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile
Gly Pro Ala Leu Asn 675 680 685 Ile Gly Asn Met Leu Tyr Lys Asp Asp
Phe Val Gly Ala Leu Ile Phe 690 695 700 Ser Gly Ala Val Ile Leu Leu
Glu Phe Ile Pro Glu Ile Ala Ile Pro 705 710 715 720 Val Leu Gly Thr
Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 725 730 735 Thr Val
Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 740 745 750
Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 755
760 765 Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu
Asn 770 775 780 Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr
Asn Gln Tyr 785 790 795 800 Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe
Asn Ile Asp Asp Leu Ser 805 810 815 Ser Lys Leu Asn Glu Ser Ile Asn
Lys Ala Met Ile Asn Ile Asn Lys 820 825 830 Phe Leu Asn Gln Cys Ser
Val Ser Tyr Leu Met Asn Ser Met Ile Pro 835 840 845 Tyr Gly Val Lys
Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala 850 855 860 Leu Leu
Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 865 870 875
880 Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro
885 890 895 Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser
Thr Leu 900 905 910 Glu Ala Leu Ala Ser Gly His His His His His His
915 920 17913PRTArtificial SequenceSynthetic sequence 17Met Gly Ser
Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val
Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25
30 Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile
35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr
Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr
Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr
Asp Leu Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile
Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val
Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser
Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155
160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu
165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg
Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu
Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr
Asp Pro Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly
His Arg Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val
Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu
Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp
Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280
285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys
290 295 300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn
Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser
Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr
Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys
Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp
Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr
Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400
Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405
410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp
Lys Gly Trp 435 440 445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro
His Ala Val Gly Asn 450 455 460 His Arg Ser Phe Ser Asp Leu Asn Gly
Leu Thr Ser Ala Leu Ala Gly 465 470 475 480 Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu 485 490 495 Val Leu Gln Cys
Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 500 505 510 Ser Glu
Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 515 520 525
Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 530
535 540 Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu
Asn 545 550 555 560 Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly
Gln Leu Glu Leu 565 570 575 Met Pro Asn Ile Glu Arg Phe Pro Asn Gly
Lys Lys Tyr Glu Leu Asp 580 585 590 Lys Tyr Thr Met Phe His Tyr Leu
Arg Ala Gln Glu Phe Glu His Gly 595 600 605 Lys Ser Arg Ile Ala Leu
Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 610 615 620 Pro Ser Arg Val
Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 625 630 635 640 Asn
Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 645 650
655 Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys
660 665 670 Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala
Leu Asn 675 680 685 Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly
Ala Leu Ile Phe 690 695 700 Ser Gly Ala Val Ile Leu Leu Glu Phe Ile
Pro Glu Ile Ala Ile Pro 705 710 715 720 Val Leu Gly Thr Phe Ala Leu
Val Ser Tyr Ile Ala Asn Lys Val Leu 725 730 735 Thr Val Gln Thr Ile
Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 740 745 750 Asp Glu Val
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 755 760 765 Thr
Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 770 775
780 Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr
785 790 795 800 Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp
Asp Leu Ser 805 810 815 Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
Ile Asn Ile Asn Lys 820 825 830 Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met Asn Ser Met Ile Pro 835 840 845 Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala Ser Leu Lys Asp Ala 850 855 860 Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 865 870 875 880 Asp Arg
Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro 885 890 895
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu 900
905 910 Asp 182769DNAArtificial SequenceSynthetic sequence
18catatgggat ccatgccggt taccatcaac aacttcaact acaacgaccc gatcgacaac
60aacaacatca ttatgatgga accgccgttc gcacgtggta ccggacgtta ctacaaggct
120tttaagatca ccgaccgtat ctggatcatc ccggaacgtt acaccttcgg
ttacaaacct 180gaggacttca acaagagtag cgggattttc aatcgtgacg
tctgcgagta ctatgatcca 240gattatctga ataccaacga taagaagaac
atattccttc agactatgat taaactcttc 300aaccgtatca aaagcaaacc
gctcggtgaa aaactcctcg aaatgattat caacggtatc 360ccgtacctcg
gtgaccgtcg tgtcccgctt gaagagttca acaccaacat cgcaagcgtc
420accgtcaaca aactcatcag caacccaggt gaagtcgaac gtaaaaaagg
tatcttcgca 480aacctcatca tcttcggtcc gggtccggtc ctcaacgaaa
acgaaaccat cgacatcggt 540atccagaacc acttcgcaag ccgtgaaggt
ttcggtggta tcatgcagat gaaattctgc 600ccggaatacg tcagtgtctt
caacaacgtc caggaaaaca aaggtgcaag catcttcaac 660cgtcgtggtt
acttcagcga cccggcactc atcctcatgc atgaactcat ccacgtcctc
720cacggtctct acggtatcaa agttgacgac ctcccgatcg tcccgaacga
gaagaaattc 780ttcatgcaga gcaccgacgc aatccaggct gaggaactct
acaccttcgg tggccaagac 840ccaagtatca taaccccgtc caccgacaaa
agcatctacg acaaagtcct ccagaacttc 900aggggtatcg tggacagact
caacaaagtc ctcgtctgca tcagcgaccc gaacatcaat 960atcaacatat
acaagaacaa gttcaaagac aagtacaaat tcgtcgagga cagcgaaggc
1020aaatacagca tcgacgtaga aagtttcgac aagctctaca aaagcctcat
gttcggtttc 1080accgaaacca acatcgccga gaactacaag atcaagacaa
gggcaagtta cttcagcgac 1140agcctcccgc ctgtcaaaat caagaacctc
ttagacaacg agatttacac aattgaagag 1200ggcttcaaca tcagtgacaa
agacatggag aaggaataca gaggtcagaa caaggctatc 1260aacaaacagg
catacgagga gatcagcaaa gaacacctcg cagtctacaa gatccagatg
1320tgcgtcgacg gcggtggcgg tagcgcagac gatgacgata aaggttggac
cctgaactct 1380gctggttacc tgctgggtcc gcacgctgtt gcgctagcgg
gcggtggcgg tagcggcggt 1440ggcggtagcg gcggtggcgg tagcgcacta
gtgctgcagt gcatcgacgt tgacaacgaa 1500gacctgttct tcatcgctga
caaaaacagc ttcagtgacg acctgagcaa aaacgaacgt 1560atcgaataca
acacccagag caactacatc gaaaacgact tcccgatcaa cgaactgatc
1620ctggacaccg acctgataag taaaatcgaa ctgccgagcg aaaacaccga
aagtctgacc 1680gacttcaacg ttgacgttcc ggtttacgaa aaacagccgg
ctatcaagaa aatcttcacc 1740gacgaaaaca ccatcttcca gtacctgtac
agccagacct tcccgctgga catccgtgac 1800atcagtctga ccagcagttt
cgacgacgct ctgctgttca gcaacaaagt ttacagtttc 1860ttcagcatgg
actacatcaa aaccgctaac aaagttgttg aagcagggct gttcgctggt
1920tgggttaaac agatcgttaa cgacttcgtt atcgaagcta acaaaagcaa
cactatggac 1980gcaatcgctg acatcagtct gatcgttccg tacatcggtc
tggctctgaa cgttggtaac 2040gaaaccgcta aaggtaactt tgaaaacgct
ttcgagatcg ctggtgcaag catcctgctg 2100gagttcatcc cggaactgct
gatcccggtt gttggtgctt tcctgctgga aagttacatc 2160gacaacaaaa
acaagatcat caaaaccatc gacaacgctc tgaccaaacg taacgaaaaa
2220tggagtgata tgtacggtct gatcgttgct cagtggctga gcaccgtcaa
cacccagttc 2280tacaccatca aagaaggtat gtacaaagct ctgaactacc
aggctcaggc tctggaagag 2340atcatcaaat accgttacaa catctacagt
gagaaggaaa agagtaacat caacatcgac 2400ttcaacgaca tcaacagcaa
actgaacgaa ggtatcaacc aggctatcga caacatcaac 2460aacttcatca
acggttgcag tgttagctac ctgatgaaga agatgatccc gctggctgtt
2520gaaaaactgc tggacttcga caacaccctg aaaaagaacc tgctgaacta
catcgacgaa 2580aacaagctgt acctgatcgg tagtgctgaa tacgaaaaaa
gtaaagtgaa caaatacctg 2640aagaccatca tgccgttcga cctgagtatc
tacaccaacg acaccatcct gatcgaaatg 2700ttcaacaaat acaactctct
agaagcacta gcgagtgggc accatcacca tcaccattaa 2760tgaaagctt
276919918PRTArtificial SequenceSynthetic sequence 19Met Gly Ser Met
Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro 1 5 10 15 Ile Asp
Asn Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg Gly 20 25 30
Thr Gly Arg Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile 35
40 45 Ile Pro Glu Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn
Lys 50 55 60 Ser Ser Gly Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr
Asp Pro Asp 65 70 75 80 Tyr Leu Asn Thr Asn Asp Lys Lys Asn Ile Phe
Leu Gln Thr Met Ile 85 90 95 Lys Leu Phe Asn Arg Ile Lys Ser Lys
Pro Leu Gly Glu Lys Leu Leu 100 105 110 Glu Met Ile Ile Asn Gly Ile
Pro Tyr Leu Gly Asp Arg Arg Val Pro 115 120 125 Leu Glu Glu Phe Asn
Thr Asn Ile Ala Ser Val Thr Val Asn Lys Leu 130 135 140 Ile Ser Asn
Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala Asn 145 150 155 160
Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile 165
170 175 Asp Ile Gly Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly
Gly 180 185 190 Ile Met Gln Met Lys Phe Cys Pro Glu Tyr Val Ser Val
Phe Asn Asn 195 200 205 Val Gln Glu Asn Lys Gly Ala Ser Ile Phe Asn
Arg Arg Gly Tyr Phe 210 215 220 Ser Asp Pro Ala Leu Ile Leu Met His
Glu Leu Ile His Val Leu His 225 230 235 240 Gly Leu Tyr Gly Ile Lys
Val Asp Asp Leu Pro Ile Val Pro Asn Glu 245 250 255 Lys Lys Phe Phe
Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu 260 265 270 Tyr Thr
Phe Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp 275 280 285
Lys Ser Ile Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp 290
295 300 Arg Leu Asn Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn
Ile 305 310 315 320 Asn Ile Tyr Lys Asn Lys Phe Lys Asp Lys Tyr Lys
Phe Val Glu Asp 325 330 335 Ser Glu Gly Lys Tyr Ser Ile Asp Val Glu
Ser Phe Asp Lys Leu Tyr 340 345 350 Lys Ser Leu Met Phe Gly Phe Thr
Glu Thr Asn Ile Ala Glu Asn Tyr 355 360 365 Lys Ile Lys Thr Arg Ala
Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val 370 375 380 Lys Ile Lys Asn
Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly 385 390 395 400 Phe
Asn Ile Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn 405 410
415 Lys Ala Ile Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu
420 425 430 Ala Val Tyr Lys Ile Gln Met Cys Val Asp Gly Gly Gly Gly
Ser Ala 435 440 445 Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala
Gly Tyr Leu Leu 450 455 460 Gly Pro His Ala Val Ala Leu Ala Gly Gly
Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser
Ala Leu Val Leu Gln Cys Ile Asp Val 485 490 495 Asp Asn Glu Asp Leu
Phe Phe Ile Ala Asp Lys Asn Ser Phe Ser Asp 500 505 510 Asp Leu Ser
Lys Asn Glu Arg Ile Glu Tyr Asn Thr Gln Ser Asn Tyr 515 520 525 Ile
Glu Asn Asp Phe Pro Ile Asn Glu Leu Ile Leu Asp Thr Asp Leu 530 535
540 Ile Ser Lys Ile Glu Leu Pro Ser Glu Asn Thr Glu Ser Leu Thr Asp
545 550 555 560 Phe Asn Val Asp Val Pro Val Tyr Glu Lys Gln Pro Ala
Ile Lys Lys 565 570 575 Ile Phe Thr Asp Glu Asn Thr Ile Phe Gln Tyr
Leu Tyr Ser Gln Thr 580 585 590 Phe Pro Leu Asp Ile Arg Asp Ile Ser
Leu Thr Ser Ser Phe Asp Asp 595 600 605 Ala Leu Leu Phe Ser Asn Lys
Val Tyr Ser Phe Phe Ser Met Asp Tyr 610 615 620 Ile Lys Thr Ala Asn
Lys Val Val Glu Ala Gly Leu Phe Ala Gly Trp 625 630 635 640 Val Lys
Gln Ile Val Asn Asp Phe Val Ile Glu Ala Asn Lys Ser Asn 645 650
655 Thr Met Asp Ala Ile Ala Asp Ile Ser Leu Ile Val Pro Tyr Ile Gly
660 665 670 Leu Ala Leu Asn Val Gly Asn Glu Thr Ala Lys Gly Asn Phe
Glu Asn 675 680 685 Ala Phe Glu Ile Ala Gly Ala Ser Ile Leu Leu Glu
Phe Ile Pro Glu 690 695 700 Leu Leu Ile Pro Val Val Gly Ala Phe Leu
Leu Glu Ser Tyr Ile Asp 705 710 715 720 Asn Lys Asn Lys Ile Ile Lys
Thr Ile Asp Asn Ala Leu Thr Lys Arg 725 730 735 Asn Glu Lys Trp Ser
Asp Met Tyr Gly Leu Ile Val Ala Gln Trp Leu 740 745 750 Ser Thr Val
Asn Thr Gln Phe Tyr Thr Ile Lys Glu Gly Met Tyr Lys 755 760 765 Ala
Leu Asn Tyr Gln Ala Gln Ala Leu Glu Glu Ile Ile Lys Tyr Arg 770 775
780 Tyr Asn Ile Tyr Ser Glu Lys Glu Lys Ser Asn Ile Asn Ile Asp Phe
785 790 795 800 Asn Asp Ile Asn Ser Lys Leu Asn Glu Gly Ile Asn Gln
Ala Ile Asp 805 810 815 Asn Ile Asn Asn Phe Ile Asn Gly Cys Ser Val
Ser Tyr Leu Met Lys 820 825 830 Lys Met Ile Pro Leu Ala Val Glu Lys
Leu Leu Asp Phe Asp Asn Thr 835 840 845 Leu Lys Lys Asn Leu Leu Asn
Tyr Ile Asp Glu Asn Lys Leu Tyr Leu 850 855 860 Ile Gly Ser Ala Glu
Tyr Glu Lys Ser Lys Val Asn Lys Tyr Leu Lys 865 870 875 880 Thr Ile
Met Pro Phe Asp Leu Ser Ile Tyr Thr Asn Asp Thr Ile Leu 885 890 895
Ile Glu Met Phe Asn Lys Tyr Asn Ser Leu Glu Ala Leu Ala Ser Gly 900
905 910 His His His His His His 915 20908PRTArtificial
SequenceSynthetic sequence 20Met Gly Ser Met Pro Val Thr Ile Asn
Asn Phe Asn Tyr Asn Asp Pro 1 5 10 15 Ile Asp Asn Asn Asn Ile Ile
Met Met Glu Pro Pro Phe Ala Arg Gly 20 25 30 Thr Gly Arg Tyr Tyr
Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile 35 40 45 Ile Pro Glu
Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys 50 55 60 Ser
Ser Gly Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp 65 70
75 80 Tyr Leu Asn Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met
Ile 85 90 95 Lys Leu Phe Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu
Lys Leu Leu 100 105 110 Glu Met Ile Ile Asn Gly Ile Pro Tyr Leu Gly
Asp Arg Arg Val Pro 115 120 125 Leu Glu Glu Phe Asn Thr Asn Ile Ala
Ser Val Thr Val Asn Lys Leu 130 135 140 Ile Ser Asn Pro Gly Glu Val
Glu Arg Lys Lys Gly Ile Phe Ala Asn 145 150 155 160 Leu Ile Ile Phe
Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile 165 170 175 Asp Ile
Gly Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly 180 185 190
Ile Met Gln Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn 195
200 205 Val Gln Glu Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr
Phe 210 215 220 Ser Asp Pro Ala Leu Ile Leu Met His Glu Leu Ile His
Val Leu His 225 230 235 240 Gly Leu Tyr Gly Ile Lys Val Asp Asp Leu
Pro Ile Val Pro Asn Glu 245 250 255 Lys Lys Phe Phe Met Gln Ser Thr
Asp Ala Ile Gln Ala Glu Glu Leu 260 265 270 Tyr Thr Phe Gly Gly Gln
Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp 275 280 285 Lys Ser Ile Tyr
Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp 290 295 300 Arg Leu
Asn Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile 305 310 315
320 Asn Ile Tyr Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp
325 330 335 Ser Glu Gly Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys
Leu Tyr 340 345 350 Lys Ser Leu Met Phe Gly Phe Thr Glu Thr Asn Ile
Ala Glu Asn Tyr 355 360 365 Lys Ile Lys Thr Arg Ala Ser Tyr Phe Ser
Asp Ser Leu Pro Pro Val 370 375 380 Lys Ile Lys Asn Leu Leu Asp Asn
Glu Ile Tyr Thr Ile Glu Glu Gly 385 390 395 400 Phe Asn Ile Ser Asp
Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn 405 410 415 Lys Ala Ile
Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu 420 425 430 Ala
Val Tyr Lys Ile Gln Met Cys Val Asp Gly Gly Gly Gly Ser Ala 435 440
445 Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu
450 455 460 Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Asp Val 485 490 495 Asp Asn Glu Asp Leu Phe Phe Ile Ala
Asp Lys Asn Ser Phe Ser Asp 500 505 510 Asp Leu Ser Lys Asn Glu Arg
Ile Glu Tyr Asn Thr Gln Ser Asn Tyr 515 520 525 Ile Glu Asn Asp Phe
Pro Ile Asn Glu Leu Ile Leu Asp Thr Asp Leu 530 535 540 Ile Ser Lys
Ile Glu Leu Pro Ser Glu Asn Thr Glu Ser Leu Thr Asp 545 550 555 560
Phe Asn Val Asp Val Pro Val Tyr Glu Lys Gln Pro Ala Ile Lys Lys 565
570 575 Ile Phe Thr Asp Glu Asn Thr Ile Phe Gln Tyr Leu Tyr Ser Gln
Thr 580 585 590 Phe Pro Leu Asp Ile Arg Asp Ile Ser Leu Thr Ser Ser
Phe Asp Asp 595 600 605 Ala Leu Leu Phe Ser Asn Lys Val Tyr Ser Phe
Phe Ser Met Asp Tyr 610 615 620 Ile Lys Thr Ala Asn Lys Val Val Glu
Ala Gly Leu Phe Ala Gly Trp 625 630 635 640 Val Lys Gln Ile Val Asn
Asp Phe Val Ile Glu Ala Asn Lys Ser Asn 645 650 655 Thr Met Asp Ala
Ile Ala Asp Ile Ser Leu Ile Val Pro Tyr Ile Gly 660 665 670 Leu Ala
Leu Asn Val Gly Asn Glu Thr Ala Lys Gly Asn Phe Glu Asn 675 680 685
Ala Phe Glu Ile Ala Gly Ala Ser Ile Leu Leu Glu Phe Ile Pro Glu 690
695 700 Leu Leu Ile Pro Val Val Gly Ala Phe Leu Leu Glu Ser Tyr Ile
Asp 705 710 715 720 Asn Lys Asn Lys Ile Ile Lys Thr Ile Asp Asn Ala
Leu Thr Lys Arg 725 730 735 Asn Glu Lys Trp Ser Asp Met Tyr Gly Leu
Ile Val Ala Gln Trp Leu 740 745 750 Ser Thr Val Asn Thr Gln Phe Tyr
Thr Ile Lys Glu Gly Met Tyr Lys 755 760 765 Ala Leu Asn Tyr Gln Ala
Gln Ala Leu Glu Glu Ile Ile Lys Tyr Arg 770 775 780 Tyr Asn Ile Tyr
Ser Glu Lys Glu Lys Ser Asn Ile Asn Ile Asp Phe 785 790 795 800 Asn
Asp Ile Asn Ser Lys Leu Asn Glu Gly Ile Asn Gln Ala Ile Asp 805 810
815 Asn Ile Asn Asn Phe Ile Asn Gly Cys Ser Val Ser Tyr Leu Met Lys
820 825 830 Lys Met Ile Pro Leu Ala Val Glu Lys Leu Leu Asp Phe Asp
Asn Thr 835 840 845 Leu Lys Lys Asn Leu Leu Asn Tyr Ile Asp Glu Asn
Lys Leu Tyr Leu 850 855 860 Ile Gly Ser Ala Glu Tyr Glu Lys Ser Lys
Val Asn Lys Tyr Leu Lys 865 870 875 880 Thr Ile Met Pro Phe Asp Leu
Ser Ile Tyr Thr Asn Asp Thr Ile Leu 885 890 895 Ile Glu Met Phe Asn
Lys Tyr Asn Ser Leu Glu Asp 900 905 212769DNAArtificial
SequenceSynthetic sequence 21catatgggat ccatgccggt taccatcaac
aacttcaact acaacgaccc gatcgacaac 60aacaacatca ttatgatgga accgccgttc
gcacgtggta ccggacgtta ctacaaggct 120tttaagatca ccgaccgtat
ctggatcatc ccggaacgtt acaccttcgg ttacaaacct 180gaggacttca
acaagagtag cgggattttc aatcgtgacg tctgcgagta ctatgatcca
240gattatctga ataccaacga taagaagaac atattccttc agactatgat
taaactcttc 300aaccgtatca aaagcaaacc gctcggtgaa aaactcctcg
aaatgattat caacggtatc 360ccgtacctcg gtgaccgtcg tgtcccgctt
gaagagttca acaccaacat cgcaagcgtc 420accgtcaaca aactcatcag
caacccaggt gaagtcgaac gtaaaaaagg tatcttcgca 480aacctcatca
tcttcggtcc gggtccggtc ctcaacgaaa acgaaaccat cgacatcggt
540atccagaacc acttcgcaag ccgtgaaggt ttcggtggta tcatgcagat
gaaattctgc 600ccggaatacg tcagtgtctt caacaacgtc caggaaaaca
aaggtgcaag catcttcaac 660cgtcgtggtt acttcagcga cccggcactc
atcctcatgc atgaactcat ccacgtcctc 720cacggtctct acggtatcaa
agttgacgac ctcccgatcg tcccgaacga gaagaaattc 780ttcatgcaga
gcaccgacgc aatccaggct gaggaactct acaccttcgg tggccaagac
840ccaagtatca taaccccgtc caccgacaaa agcatctacg acaaagtcct
ccagaacttc 900aggggtatcg tggacagact caacaaagtc ctcgtctgca
tcagcgaccc gaacatcaat 960atcaacatat acaagaacaa gttcaaagac
aagtacaaat tcgtcgagga cagcgaaggc 1020aaatacagca tcgacgtaga
aagtttcgac aagctctaca aaagcctcat gttcggtttc 1080accgaaacca
acatcgccga gaactacaag atcaagacaa gggcaagtta cttcagcgac
1140agcctcccgc ctgtcaaaat caagaacctc ttagacaacg agatttacac
aattgaagag 1200ggcttcaaca tcagtgacaa agacatggag aaggaataca
gaggtcagaa caaggctatc 1260aacaaacagg catacgagga gatcagcaaa
gaacacctcg cagtctacaa gatccagatg 1320tgcgtcgacg gcggtggcgg
tagcgcagac gatgacgata aaggttggac cctgaactct 1380gctggttacc
tgctgggtcc gcacgctgtt gcgctagcgg gcggtggcgg tagcggcggt
1440ggcggtagcg gcggtggcgg tagcgcacta gtgctgcagt gcatcgacgt
tgacaacgaa 1500gacctgttct tcatcgctga caaaaacagc ttcagtgacg
acctgagcaa aaacgaacgt 1560atcgaataca acacccagag caactacatc
gaaaacgact tcccgatcaa cgaactgatc 1620ctggacaccg acctgataag
taaaatcgaa ctgccgagcg aaaacaccga aagtctgacc 1680gacttcaacg
ttgacgttcc ggtttacgaa aaacagccgg ctatcaagaa aatcttcacc
1740gacgaaaaca ccatcttcca gtacctgtac agccagacct tcccgctgga
catccgtgac 1800atcagtctga ccagcagttt cgacgacgct ctgctgttca
gcaacaaagt ttacagtttc 1860ttcagcatgg actacatcaa aaccgctaac
aaagttgttg aagcagggct gttcgctggt 1920tgggttaaac agatcgttaa
cgacttcgtt atcgaagcta acaaaagcaa cactatggac 1980aaaatcgctg
acatcagtct gatcgttccg tacatcggtc tggctctgaa cgttggtaac
2040gaaaccgcta aaggtaactt tgaaaacgct ttcgagatcg ctggtgcaag
catcctgctg 2100gagttcatcc cggaactgct gatcccggtt gttggtgctt
tcctgctgga aagttacatc 2160gacaacaaaa acaagatcat caaaaccatc
gacaacgctc tgaccaaacg taacgaaaaa 2220tggagtgata tgtacggtct
gatcgttgct cagtggctga gcaccgtcaa cacccagttc 2280tacaccatca
aagaaggtat gtacaaagct ctgaactacc aggctcaggc tctggaagag
2340atcatcaaat accgttacaa catctacagt gagaaggaaa agagtaacat
caacatcgac 2400ttcaacgaca tcaacagcaa actgaacgaa ggtatcaacc
aggctatcga caacatcaac 2460aacttcatca acggttgcag tgttagctac
ctgatgaaga agatgatccc gctggctgtt 2520gaaaaactgc tggacttcga
caacaccctg aaaaagaacc tgctgaacta catcgacgaa 2580aacaagctgt
acctgatcgg tagtgctgaa tacgaaaaaa gtaaagtgaa caaatacctg
2640aagaccatca tgccgttcga cctgagtatc tacaccaacg acaccatcct
gatcgaaatg 2700ttcaacaaat acaactctct agaagcacta gcgagtgggc
accatcacca tcaccattaa 2760tgaaagctt 276922918PRTArtificial
SequenceSynthetic sequence 22Met Gly Ser Met Pro Val Thr Ile Asn
Asn Phe Asn Tyr Asn Asp Pro 1 5 10 15 Ile Asp Asn Asn Asn Ile Ile
Met Met Glu Pro Pro Phe Ala Arg Gly 20 25 30 Thr Gly Arg Tyr Tyr
Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile 35 40 45 Ile Pro Glu
Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys 50 55 60 Ser
Ser Gly Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp 65 70
75 80 Tyr Leu Asn Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met
Ile 85 90 95 Lys Leu Phe Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu
Lys Leu Leu 100 105 110 Glu Met Ile Ile Asn Gly Ile Pro Tyr Leu Gly
Asp Arg Arg Val Pro 115 120 125 Leu Glu Glu Phe Asn Thr Asn Ile Ala
Ser Val Thr Val Asn Lys Leu 130 135 140 Ile Ser Asn Pro Gly Glu Val
Glu Arg Lys Lys Gly Ile Phe Ala Asn 145 150 155 160 Leu Ile Ile Phe
Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile 165 170 175 Asp Ile
Gly Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly 180 185 190
Ile Met Gln Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn 195
200 205 Val Gln Glu Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr
Phe 210 215 220 Ser Asp Pro Ala Leu Ile Leu Met His Glu Leu Ile His
Val Leu His 225 230 235 240 Gly Leu Tyr Gly Ile Lys Val Asp Asp Leu
Pro Ile Val Pro Asn Glu 245 250 255 Lys Lys Phe Phe Met Gln Ser Thr
Asp Ala Ile Gln Ala Glu Glu Leu 260 265 270 Tyr Thr Phe Gly Gly Gln
Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp 275 280 285 Lys Ser Ile Tyr
Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp 290 295 300 Arg Leu
Asn Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile 305 310 315
320 Asn Ile Tyr Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp
325 330 335 Ser Glu Gly Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys
Leu Tyr 340 345 350 Lys Ser Leu Met Phe Gly Phe Thr Glu Thr Asn Ile
Ala Glu Asn Tyr 355 360 365 Lys Ile Lys Thr Arg Ala Ser Tyr Phe Ser
Asp Ser Leu Pro Pro Val 370 375 380 Lys Ile Lys Asn Leu Leu Asp Asn
Glu Ile Tyr Thr Ile Glu Glu Gly 385 390 395 400 Phe Asn Ile Ser Asp
Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn 405 410 415 Lys Ala Ile
Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu 420 425 430 Ala
Val Tyr Lys Ile Gln Met Cys Val Asp Gly Gly Gly Gly Ser Ala 435 440
445 Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu
450 455 460 Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Asp Val 485 490 495 Asp Asn Glu Asp Leu Phe Phe Ile Ala
Asp Lys Asn Ser Phe Ser Asp 500 505 510 Asp Leu Ser Lys Asn Glu Arg
Ile Glu Tyr Asn Thr Gln Ser Asn Tyr 515 520 525 Ile Glu Asn Asp Phe
Pro Ile Asn Glu Leu Ile Leu Asp Thr Asp Leu 530 535 540 Ile Ser Lys
Ile Glu Leu Pro Ser Glu Asn Thr Glu Ser Leu Thr Asp 545 550 555 560
Phe Asn Val Asp Val Pro Val Tyr Glu Lys Gln Pro Ala Ile Lys Lys 565
570 575 Ile Phe Thr Asp Glu Asn Thr Ile Phe Gln Tyr Leu Tyr Ser Gln
Thr 580 585 590 Phe Pro Leu Asp Ile Arg Asp Ile Ser Leu Thr Ser Ser
Phe Asp Asp 595 600 605 Ala Leu Leu Phe Ser Asn Lys Val Tyr Ser Phe
Phe Ser Met Asp Tyr 610 615 620 Ile Lys Thr Ala Asn Lys Val Val Glu
Ala Gly Leu Phe Ala Gly Trp 625 630 635 640 Val Lys Gln Ile Val Asn
Asp Phe Val Ile Glu Ala Asn Lys Ser Asn 645 650 655 Thr Met Asp Lys
Ile Ala Asp Ile Ser Leu Ile Val Pro Tyr Ile Gly 660 665 670 Leu Ala
Leu Asn Val Gly Asn Glu Thr Ala Lys Gly Asn Phe Glu Asn
675 680 685 Ala Phe Glu Ile Ala Gly Ala Ser Ile Leu Leu Glu Phe Ile
Pro Glu 690 695 700 Leu Leu Ile Pro Val Val Gly Ala Phe Leu Leu Glu
Ser Tyr Ile Asp 705 710 715 720 Asn Lys Asn Lys Ile Ile Lys Thr Ile
Asp Asn Ala Leu Thr Lys Arg 725 730 735 Asn Glu Lys Trp Ser Asp Met
Tyr Gly Leu Ile Val Ala Gln Trp Leu 740 745 750 Ser Thr Val Asn Thr
Gln Phe Tyr Thr Ile Lys Glu Gly Met Tyr Lys 755 760 765 Ala Leu Asn
Tyr Gln Ala Gln Ala Leu Glu Glu Ile Ile Lys Tyr Arg 770 775 780 Tyr
Asn Ile Tyr Ser Glu Lys Glu Lys Ser Asn Ile Asn Ile Asp Phe 785 790
795 800 Asn Asp Ile Asn Ser Lys Leu Asn Glu Gly Ile Asn Gln Ala Ile
Asp 805 810 815 Asn Ile Asn Asn Phe Ile Asn Gly Cys Ser Val Ser Tyr
Leu Met Lys 820 825 830 Lys Met Ile Pro Leu Ala Val Glu Lys Leu Leu
Asp Phe Asp Asn Thr 835 840 845 Leu Lys Lys Asn Leu Leu Asn Tyr Ile
Asp Glu Asn Lys Leu Tyr Leu 850 855 860 Ile Gly Ser Ala Glu Tyr Glu
Lys Ser Lys Val Asn Lys Tyr Leu Lys 865 870 875 880 Thr Ile Met Pro
Phe Asp Leu Ser Ile Tyr Thr Asn Asp Thr Ile Leu 885 890 895 Ile Glu
Met Phe Asn Lys Tyr Asn Ser Leu Glu Ala Leu Ala Ser Gly 900 905 910
His His His His His His 915 23907PRTArtificial SequenceSynthetic
sequence 23Met Gly Ser Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn
Asp Pro 1 5 10 15 Ile Asp Asn Asn Asn Ile Ile Met Met Glu Pro Pro
Phe Ala Arg Gly 20 25 30 Thr Gly Arg Tyr Tyr Lys Ala Phe Lys Ile
Thr Asp Arg Ile Trp Ile 35 40 45 Ile Pro Glu Arg Tyr Thr Phe Gly
Tyr Lys Pro Glu Asp Phe Asn Lys 50 55 60 Ser Ser Gly Ile Phe Asn
Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp 65 70 75 80 Tyr Leu Asn Thr
Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met Ile 85 90 95 Lys Leu
Phe Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu 100 105 110
Glu Met Ile Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro 115
120 125 Leu Glu Glu Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys
Leu 130 135 140 Ile Ser Asn Pro Gly Glu Val Glu Arg Lys Lys Gly Ile
Phe Ala Asn 145 150 155 160 Leu Ile Ile Phe Gly Pro Gly Pro Val Leu
Asn Glu Asn Glu Thr Ile 165 170 175 Asp Ile Gly Ile Gln Asn His Phe
Ala Ser Arg Glu Gly Phe Gly Gly 180 185 190 Ile Met Gln Met Lys Phe
Cys Pro Glu Tyr Val Ser Val Phe Asn Asn 195 200 205 Val Gln Glu Asn
Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe 210 215 220 Ser Asp
Pro Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu His 225 230 235
240 Gly Leu Tyr Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn Glu
245 250 255 Lys Lys Phe Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu
Glu Leu 260 265 270 Tyr Thr Phe Gly Gly Gln Asp Pro Ser Ile Ile Thr
Pro Ser Thr Asp 275 280 285 Lys Ser Ile Tyr Asp Lys Val Leu Gln Asn
Phe Arg Gly Ile Val Asp 290 295 300 Arg Leu Asn Lys Val Leu Val Cys
Ile Ser Asp Pro Asn Ile Asn Ile 305 310 315 320 Asn Ile Tyr Lys Asn
Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp 325 330 335 Ser Glu Gly
Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr 340 345 350 Lys
Ser Leu Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr 355 360
365 Lys Ile Lys Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val
370 375 380 Lys Ile Lys Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu
Glu Gly 385 390 395 400 Phe Asn Ile Ser Asp Lys Asp Met Glu Lys Glu
Tyr Arg Gly Gln Asn 405 410 415 Lys Ala Ile Asn Lys Gln Ala Tyr Glu
Glu Ile Ser Lys Glu His Leu 420 425 430 Ala Val Tyr Lys Ile Gln Met
Cys Val Asp Gly Gly Gly Gly Ser Ala 435 440 445 Asp Asp Asp Asp Lys
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu 450 455 460 Gly Pro His
Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 465 470 475 480
Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Asp Val 485
490 495 Asp Asn Glu Asp Leu Phe Phe Ile Ala Asp Lys Asn Ser Phe Ser
Asp 500 505 510 Asp Leu Ser Lys Asn Glu Arg Ile Glu Tyr Asn Thr Gln
Ser Asn Tyr 515 520 525 Ile Glu Asn Asp Phe Pro Ile Asn Glu Leu Ile
Leu Asp Thr Asp Leu 530 535 540 Ile Ser Lys Ile Glu Leu Pro Ser Glu
Asn Thr Glu Ser Leu Thr Asp 545 550 555 560 Phe Asn Val Asp Val Pro
Val Tyr Glu Lys Gln Pro Ala Ile Lys Lys 565 570 575 Ile Phe Thr Asp
Glu Asn Thr Ile Phe Gln Tyr Leu Tyr Ser Gln Thr 580 585 590 Phe Pro
Leu Asp Ile Arg Asp Ile Ser Leu Thr Ser Ser Phe Asp Asp 595 600 605
Ala Leu Leu Phe Ser Asn Lys Val Tyr Ser Phe Phe Ser Met Asp Tyr 610
615 620 Ile Lys Thr Ala Asn Lys Val Val Glu Ala Gly Leu Phe Ala Gly
Trp 625 630 635 640 Val Lys Gln Ile Val Asn Asp Phe Val Ile Glu Ala
Asn Lys Ser Asn 645 650 655 Thr Met Asp Lys Ile Ala Asp Ile Ser Leu
Ile Val Pro Tyr Ile Gly 660 665 670 Leu Ala Leu Asn Val Gly Asn Glu
Thr Ala Lys Gly Asn Phe Glu Asn 675 680 685 Ala Phe Glu Ile Ala Gly
Ala Ser Ile Leu Leu Glu Phe Ile Pro Glu 690 695 700 Leu Leu Ile Pro
Val Val Gly Ala Phe Leu Leu Glu Ser Tyr Ile Asp 705 710 715 720 Asn
Lys Asn Lys Ile Ile Lys Thr Ile Asp Asn Ala Leu Thr Lys Arg 725 730
735 Asn Glu Lys Trp Ser Asp Met Tyr Gly Leu Ile Val Ala Gln Trp Leu
740 745 750 Ser Thr Val Asn Thr Gln Phe Tyr Thr Ile Lys Glu Gly Met
Tyr Lys 755 760 765 Ala Leu Asn Tyr Gln Ala Gln Ala Leu Glu Glu Ile
Ile Lys Tyr Arg 770 775 780 Tyr Asn Ile Tyr Ser Glu Lys Glu Lys Ser
Asn Ile Asn Ile Asp Phe 785 790 795 800 Asn Asp Ile Asn Ser Lys Leu
Asn Glu Gly Ile Asn Gln Ala Ile Asp 805 810 815 Asn Ile Asn Asn Phe
Ile Asn Gly Cys Ser Val Ser Tyr Leu Met Lys 820 825 830 Lys Met Ile
Pro Leu Ala Val Glu Lys Leu Leu Asp Phe Asp Asn Thr 835 840 845 Leu
Lys Lys Asn Leu Leu Asn Tyr Ile Asp Glu Asn Lys Leu Tyr Leu 850 855
860 Ile Gly Ser Ala Glu Tyr Glu Lys Ser Lys Val Asn Lys Tyr Leu Lys
865 870 875 880 Thr Ile Met Pro Phe Asp Leu Ser Ile Tyr Thr Asn Asp
Thr Ile Leu 885 890 895 Ile Glu Met Phe Asn Lys Tyr Asn Ser Leu Asp
900 905 242778DNAArtificial SequenceSynthetic sequence 24catatgggat
ccgaattcat gccgatcacc atcaacaact tcaactacag cgatccggtg 60gataacaaaa
acatcctgta cctggatacc catctgaata ccctggcgaa cgaaccggaa
120aaagcgtttc gtatcaccgg caacatttgg gttattccgg atcgttttag
ccgtaacagc 180aacccgaatc tgaataaacc gccgcgtgtt accagcccga
aaagcggtta ttacgatccg 240aactatctga gcaccgatag cgataaagat
accttcctga aagaaatcat caaactgttc 300aaacgcatca acagccgtga
aattggcgaa gaactgatct atcgcctgag caccgatatt 360ccgtttccgg
gcaacaacaa caccccgatc aacacctttg atttcgatgt ggatttcaac
420agcgttgatg ttaaaacccg ccagggtaac aattgggtga aaaccggcag
cattaacccg 480agcgtgatta ttaccggtcc gcgcgaaaac attattgatc
cggaaaccag cacctttaaa 540ctgaccaaca acacctttgc ggcgcaggaa
ggttttggcg cgctgagcat tattagcatt 600agcccgcgct ttatgctgac
ctatagcaac gcgaccaacg atgttggtga aggccgtttc 660agcaaaagcg
aattttgcat ggacccgatc ctgatcctga tgcatgaact gaaccatgcg
720atgcataacc tgtatggcat cgcgattccg aacgatcaga ccattagcag
cgtgaccagc 780aacatctttt acagccagta caacgtgaaa ctggaatatg
cggaaatcta tgcgtttggc 840ggtccgacca ttgatctgat tccgaaaagc
gcgcgcaaat acttcgaaga aaaagcgctg 900gattactatc gcagcattgc
gaaacgtctg aacagcatta ccaccgcgaa tccgagcagc 960ttcaacaaat
atatcggcga atataaacag aaactgatcc gcaaatatcg ctttgtggtg
1020gaaagcagcg gcgaagttac cgttaaccgc aataaattcg tggaactgta
caacgaactg 1080acccagatct tcaccgaatt taactatgcg aaaatctata
acgtgcagaa ccgtaaaatc 1140tacctgagca acgtgtatac cccggtgacc
gcgaatattc tggatgataa cgtgtacgat 1200atccagaacg gctttaacat
cccgaaaagc aacctgaacg ttctgtttat gggccagaac 1260ctgagccgta
atccggcgct gcgtaaagtg aacccggaaa acatgctgta cctgttcacc
1320aaattttgcg tcgacggcgg tggcggtagc gcagacgatg acgataaagg
ttggaccctg 1380aactctgctg gttacctgct gggtccgcac gctgttgcgc
tagcgggcgg tggcggtagc 1440ggcggtggcg gtagcggcgg tggcggtagc
gcactagtgc tgcagtgtcg tgaactgctg 1500gtgaaaaaca ccgatctgcc
gtttattggc gatatcagcg atgtgaaaac cgatatcttc 1560ctgcgcaaag
atatcaacga agaaaccgaa gtgatctact acccggataa cgtgagcgtt
1620gatcaggtga tcctgagcaa aaacaccagc gaacatggtc agctggatct
gctgtatccg 1680agcattgata gcgaaagcga aattctgccg ggcgaaaacc
aggtgtttta cgataaccgt 1740acccagaacg tggattacct gaacagctat
tactacctgg aaagccagaa actgagcgat 1800aacgtggaag attttacctt
tacccgcagc attgaagaag cgctggataa cagcgcgaaa 1860gtttacacct
attttccgac cctggcgaac aaagttaatg cgggtgttca gggcggtctg
1920tttctgatgt gggcgaacga tgtggtggaa gatttcacca ccaacatcct
gcgtaaagat 1980accctggata aaatcagcga tgttagcgcg attattccgt
atattggtcc ggcgctgaac 2040attagcaata gcgtgcgtcg tggcaatttt
accgaagcgt ttgcggttac cggtgtgacc 2100attctgctgg aagcgtttcc
ggaatttacc attccggcgc tgggtgcgtt tgtgatctat 2160agcaaagtgc
aggaacgcaa cgaaatcatc aaaaccatcg ataactgcct ggaacagcgt
2220attaaacgct ggaaagatag ctatgaatgg atgatgggca cctggctgag
ccgtattatc 2280acccagttca acaacatcag ctaccagatg tacgatagcc
tgaactatca ggcgggtgcg 2340attaaagcga aaatcgatct ggaatacaaa
aaatacagcg gcagcgataa agaaaacatc 2400aaaagccagg ttgaaaacct
gaaaaacagc ctggatgtga aaattagcga agcgatgaat 2460aacatcaaca
aattcatccg cgaatgcagc gtgacctacc tgttcaaaaa catgctgccg
2520aaagtgatcg atgaactgaa cgaatttgat cgcaacacca aagcgaaact
gatcaacctg 2580atcgatagcc acaacattat tctggtgggc gaagtggata
aactgaaagc gaaagttaac 2640aacagcttcc agaacaccat cccgtttaac
atcttcagct ataccaacaa cagcctgctg 2700aaagatatca tcaacgaata
cttcaatcta gaagcactag cgagtgggca ccatcaccat 2760caccattaat gaaagctt
277825921PRTArtificial SequenceSynthetic sequence 25Met Gly Ser Glu
Phe Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser 1 5 10 15 Asp Pro
Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn 20 25 30
Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile 35
40 45 Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu
Asn 50 55 60 Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr
Asp Pro Asn 65 70 75 80 Tyr Leu Ser Thr Asp Ser Asp Lys Asp Thr Phe
Leu Lys Glu Ile Ile 85 90 95 Lys Leu Phe Lys Arg Ile Asn Ser Arg
Glu Ile Gly Glu Glu Leu Ile 100 105 110 Tyr Arg Leu Ser Thr Asp Ile
Pro Phe Pro Gly Asn Asn Asn Thr Pro 115 120 125 Ile Asn Thr Phe Asp
Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys 130 135 140 Thr Arg Gln
Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser 145 150 155 160
Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser 165
170 175 Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe
Gly 180 185 190 Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu
Thr Tyr Ser 195 200 205 Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe
Ser Lys Ser Glu Phe 210 215 220 Cys Met Asp Pro Ile Leu Ile Leu Met
His Glu Leu Asn His Ala Met 225 230 235 240 His Asn Leu Tyr Gly Ile
Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser 245 250 255 Val Thr Ser Asn
Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr 260 265 270 Ala Glu
Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys 275 280 285
Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser 290
295 300 Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser
Phe 305 310 315 320 Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile
Arg Lys Tyr Arg 325 330 335 Phe Val Val Glu Ser Ser Gly Glu Val Thr
Val Asn Arg Asn Lys Phe 340 345 350 Val Glu Leu Tyr Asn Glu Leu Thr
Gln Ile Phe Thr Glu Phe Asn Tyr 355 360 365 Ala Lys Ile Tyr Asn Val
Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val 370 375 380 Tyr Thr Pro Val
Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile 385 390 395 400 Gln
Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met 405 410
415 Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu
420 425 430 Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys Val Asp Gly Gly
Gly Gly 435 440 445 Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn
Ser Ala Gly Tyr 450 455 460 Leu Leu Gly Pro His Ala Val Ala Leu Ala
Gly Gly Gly Gly Ser Gly 465 470 475 480 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Leu Val Leu Gln Cys Arg 485 490 495 Glu Leu Leu Val Lys
Asn Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser 500 505 510 Asp Val Lys
Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr 515 520 525 Glu
Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu 530 535
540 Ser Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser
545 550 555 560 Ile Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln
Val Phe Tyr 565 570 575 Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn
Ser Tyr Tyr Tyr Leu 580 585 590 Glu Ser Gln Lys Leu Ser Asp Asn Val
Glu Asp Phe Thr Phe Thr Arg 595 600 605 Ser Ile Glu Glu Ala Leu Asp
Asn Ser Ala Lys Val Tyr Thr Tyr Phe 610 615 620 Pro Thr Leu Ala Asn
Lys Val Asn Ala Gly Val Gln Gly Gly Leu Phe 625 630 635 640 Leu Met
Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn Ile Leu 645 650 655
Arg Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro 660
665 670 Tyr Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly
Asn 675 680 685 Phe Thr Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu
Leu Glu Ala 690 695 700 Phe Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala
Phe Val
Ile Tyr Ser 705 710 715 720 Lys Val Gln Glu Arg Asn Glu Ile Ile Lys
Thr Ile Asp Asn Cys Leu 725 730 735 Glu Gln Arg Ile Lys Arg Trp Lys
Asp Ser Tyr Glu Trp Met Met Gly 740 745 750 Thr Trp Leu Ser Arg Ile
Ile Thr Gln Phe Asn Asn Ile Ser Tyr Gln 755 760 765 Met Tyr Asp Ser
Leu Asn Tyr Gln Ala Gly Ala Ile Lys Ala Lys Ile 770 775 780 Asp Leu
Glu Tyr Lys Lys Tyr Ser Gly Ser Asp Lys Glu Asn Ile Lys 785 790 795
800 Ser Gln Val Glu Asn Leu Lys Asn Ser Leu Asp Val Lys Ile Ser Glu
805 810 815 Ala Met Asn Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser Val
Thr Tyr 820 825 830 Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp Glu
Leu Asn Glu Phe 835 840 845 Asp Arg Asn Thr Lys Ala Lys Leu Ile Asn
Leu Ile Asp Ser His Asn 850 855 860 Ile Ile Leu Val Gly Glu Val Asp
Lys Leu Lys Ala Lys Val Asn Asn 865 870 875 880 Ser Phe Gln Asn Thr
Ile Pro Phe Asn Ile Phe Ser Tyr Thr Asn Asn 885 890 895 Ser Leu Leu
Lys Asp Ile Ile Asn Glu Tyr Phe Asn Leu Glu Ala Leu 900 905 910 Ala
Ser Gly His His His His His His 915 920 26910PRTArtificial
SequenceSynthetic sequence 26Met Gly Ser Glu Phe Met Pro Ile Thr
Ile Asn Asn Phe Asn Tyr Ser 1 5 10 15 Asp Pro Val Asp Asn Lys Asn
Ile Leu Tyr Leu Asp Thr His Leu Asn 20 25 30 Thr Leu Ala Asn Glu
Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile 35 40 45 Trp Val Ile
Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn 50 55 60 Lys
Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn 65 70
75 80 Tyr Leu Ser Thr Asp Ser Asp Lys Asp Thr Phe Leu Lys Glu Ile
Ile 85 90 95 Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu
Glu Leu Ile 100 105 110 Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly
Asn Asn Asn Thr Pro 115 120 125 Ile Asn Thr Phe Asp Phe Asp Val Asp
Phe Asn Ser Val Asp Val Lys 130 135 140 Thr Arg Gln Gly Asn Asn Trp
Val Lys Thr Gly Ser Ile Asn Pro Ser 145 150 155 160 Val Ile Ile Thr
Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser 165 170 175 Thr Phe
Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly 180 185 190
Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser 195
200 205 Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu
Phe 210 215 220 Cys Met Asp Pro Ile Leu Ile Leu Met His Glu Leu Asn
His Ala Met 225 230 235 240 His Asn Leu Tyr Gly Ile Ala Ile Pro Asn
Asp Gln Thr Ile Ser Ser 245 250 255 Val Thr Ser Asn Ile Phe Tyr Ser
Gln Tyr Asn Val Lys Leu Glu Tyr 260 265 270 Ala Glu Ile Tyr Ala Phe
Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys 275 280 285 Ser Ala Arg Lys
Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser 290 295 300 Ile Ala
Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe 305 310 315
320 Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg
325 330 335 Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn
Lys Phe 340 345 350 Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr
Glu Phe Asn Tyr 355 360 365 Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys
Ile Tyr Leu Ser Asn Val 370 375 380 Tyr Thr Pro Val Thr Ala Asn Ile
Leu Asp Asp Asn Val Tyr Asp Ile 385 390 395 400 Gln Asn Gly Phe Asn
Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met 405 410 415 Gly Gln Asn
Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu 420 425 430 Asn
Met Leu Tyr Leu Phe Thr Lys Phe Cys Val Asp Gly Gly Gly Gly 435 440
445 Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr
450 455 460 Leu Leu Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly Gly
Ser Gly 465 470 475 480 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu
Val Leu Gln Cys Arg 485 490 495 Glu Leu Leu Val Lys Asn Thr Asp Leu
Pro Phe Ile Gly Asp Ile Ser 500 505 510 Asp Val Lys Thr Asp Ile Phe
Leu Arg Lys Asp Ile Asn Glu Glu Thr 515 520 525 Glu Val Ile Tyr Tyr
Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu 530 535 540 Ser Lys Asn
Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser 545 550 555 560
Ile Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr 565
570 575 Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr
Leu 580 585 590 Glu Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr
Phe Thr Arg 595 600 605 Ser Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys
Val Tyr Thr Tyr Phe 610 615 620 Pro Thr Leu Ala Asn Lys Val Asn Ala
Gly Val Gln Gly Gly Leu Phe 625 630 635 640 Leu Met Trp Ala Asn Asp
Val Val Glu Asp Phe Thr Thr Asn Ile Leu 645 650 655 Arg Lys Asp Thr
Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro 660 665 670 Tyr Ile
Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly Asn 675 680 685
Phe Thr Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu Leu Glu Ala 690
695 700 Phe Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala Phe Val Ile Tyr
Ser 705 710 715 720 Lys Val Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile
Asp Asn Cys Leu 725 730 735 Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser
Tyr Glu Trp Met Met Gly 740 745 750 Thr Trp Leu Ser Arg Ile Ile Thr
Gln Phe Asn Asn Ile Ser Tyr Gln 755 760 765 Met Tyr Asp Ser Leu Asn
Tyr Gln Ala Gly Ala Ile Lys Ala Lys Ile 770 775 780 Asp Leu Glu Tyr
Lys Lys Tyr Ser Gly Ser Asp Lys Glu Asn Ile Lys 785 790 795 800 Ser
Gln Val Glu Asn Leu Lys Asn Ser Leu Asp Val Lys Ile Ser Glu 805 810
815 Ala Met Asn Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser Val Thr Tyr
820 825 830 Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp Glu Leu Asn
Glu Phe 835 840 845 Asp Arg Asn Thr Lys Ala Lys Leu Ile Asn Leu Ile
Asp Ser His Asn 850 855 860 Ile Ile Leu Val Gly Glu Val Asp Lys Leu
Lys Ala Lys Val Asn Asn 865 870 875 880 Ser Phe Gln Asn Thr Ile Pro
Phe Asn Ile Phe Ser Tyr Thr Asn Asn 885 890 895 Ser Leu Leu Lys Asp
Ile Ile Asn Glu Tyr Phe Asn Leu Asp 900 905 910 272769DNAArtificial
SequenceSynthetic sequence 27catatgggat ccatgacgtg gccagttaag
gatttcaact actcagatcc tgtaaatgac 60aacgatattc tgtaccttcg cattccacaa
aataaactga tcaccacacc agtcaaagca 120ttcatgatta ctcaaaacat
ttgggtcatt ccagaacgct tttctagtga cacaaatccg 180agtttatcta
aacctccgcg tccgacgtcc aaatatcaga gctattacga tccctcatat
240ctcagtacgg acgaacaaaa agatactttc cttaaaggta tcattaaact
gtttaagcgt 300attaatgagc gcgatatcgg gaaaaagttg attaattatc
ttgttgtggg ttccccgttc 360atgggcgata gctctacccc cgaagacact
tttgatttta cccgtcatac gacaaacatc 420gcggtagaga agtttgagaa
cggatcgtgg aaagtcacaa acatcattac acctagcgtc 480ttaatttttg
gtccgctgcc aaacatctta gattatacag ccagcctgac tttgcagggg
540caacagtcga atccgagttt cgaaggtttt ggtaccctga gcattctgaa
agttgccccg 600gaatttctgc tcactttttc agatgtcacc agcaaccaga
gctcagcagt attaggaaag 660tcaatttttt gcatggaccc ggttattgca
ctgatgcacg aactgacgca ctctctgcat 720caactgtatg ggatcaacat
ccccagtgac aaacgtattc gtccccaggt gtctgaagga 780tttttctcac
aggatgggcc gaacgtccag ttcgaagagt tgtatacttt cggaggcctg
840gacgtagaga tcattcccca gattgagcgc agtcagctgc gtgagaaggc
attgggccat 900tataaggata ttgcaaaacg cctgaataac attaacaaaa
cgattccatc ttcgtggatc 960tcgaatattg ataaatataa gaaaattttt
agcgagaaat ataattttga taaagataat 1020acaggtaact ttgtggttaa
cattgacaaa ttcaactccc tttacagtga tttgacgaat 1080gtaatgagcg
aagttgtgta tagttcccaa tacaacgtta agaatcgtac ccattacttc
1140tctcgtcact acctgccggt tttcgcgaac atccttgacg ataatattta
cactattcgt 1200gacggcttta acttgaccaa caagggcttc aatattgaaa
attcaggcca gaacattgaa 1260cgcaacccgg ccttgcagaa actgtcgagt
gaatccgtgg ttgacctgtt taccaaagtc 1320tgcgtcgacg gcggtggcgg
tagcgcagac gatgacgata aaggttggac cctgaactct 1380gctggttacc
tgctgggtcc gcacgctgtt gcgctagcgg gcggtggcgg tagcggcggt
1440ggcggtagcg gcggtggcgg tagcgcacta gtgctgcagt gtattaaagt
gaaaaacaat 1500cggctgcctt atgtagcaga taaagatagc attagtcagg
agattttcga aaataaaatt 1560atcactgacg aaaccaatgt tcagaattat
tcagataaat tttcactgga cgaaagcatc 1620ttagatggcc aagttccgat
taacccggaa attgttgatc cgttactgcc gaacgtgaat 1680atggaaccgt
taaacctccc tggcgaagag atcgtatttt atgatgacat tacgaaatat
1740gtggactacc ttaattctta ttactatttg gaaagccaga aactgtccaa
taacgtggaa 1800aacattactc tgaccacaag cgtggaagag gctttaggct
actcaaataa gatttatacc 1860ttcctcccgt cgctggcgga aaaagtaaat
aaaggtgtgc aggctggtct gttcctcaac 1920tgggcgaatg aagttgtcga
agactttacc acgaatatta tgaaaaagga taccctggat 1980aaaatctccg
acgtctcggt tattatccca tatattggcc ctgcgttaaa tatcggtaat
2040agtgcgctgc gggggaattt taaccaggcc tttgctaccg cgggcgtcgc
gttcctcctg 2100gagggctttc ctgaatttac tatcccggcg ctcggtgttt
ttacatttta ctcttccatc 2160caggagcgtg agaaaattat caaaaccatc
gaaaactgcc tggagcagcg ggtgaaacgc 2220tggaaagatt cttatcaatg
gatggtgtca aactggttat ctcgcatcac gacccaattc 2280aaccatatta
attaccagat gtatgatagt ctgtcgtacc aagctgacgc cattaaagcc
2340aaaattgatc tggaatataa aaagtactct ggtagcgata aggagaacat
caaaagccag 2400gtggagaacc ttaagaatag tctggatgtg aaaatctctg
aagctatgaa taacattaac 2460aaattcattc gtgaatgttc ggtgacgtac
ctgttcaaga atatgctgcc aaaagttatt 2520gatgaactga ataaatttga
tctgcgtacc aaaaccgaac ttatcaacct catcgactcc 2580cacaacatta
tccttgtggg cgaagtggat cgtctgaagg ccaaagtaaa cgagagcttt
2640gaaaatacga tgccgtttaa tattttttca tataccaata actccttgct
gaaagatatc 2700atcaatgaat atttcaatct agaagcacta gcgagtgggc
accatcacca tcaccattaa 2760tgaaagctt 276928918PRTArtificial
SequenceSynthetic sequence 28Met Gly Ser Met Thr Trp Pro Val Lys
Asp Phe Asn Tyr Ser Asp Pro 1 5 10 15 Val Asn Asp Asn Asp Ile Leu
Tyr Leu Arg Ile Pro Gln Asn Lys Leu 20 25 30 Ile Thr Thr Pro Val
Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val 35 40 45 Ile Pro Glu
Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro 50 55 60 Pro
Arg Pro Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu 65 70
75 80 Ser Thr Asp Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys
Leu 85 90 95 Phe Lys Arg Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu
Ile Asn Tyr 100 105 110 Leu Val Val Gly Ser Pro Phe Met Gly Asp Ser
Ser Thr Pro Glu Asp 115 120 125 Thr Phe Asp Phe Thr Arg His Thr Thr
Asn Ile Ala Val Glu Lys Phe 130 135 140 Glu Asn Gly Ser Trp Lys Val
Thr Asn Ile Ile Thr Pro Ser Val Leu 145 150 155 160 Ile Phe Gly Pro
Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr 165 170 175 Leu Gln
Gly Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu 180 185 190
Ser Ile Leu Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp Val 195
200 205 Thr Ser Asn Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys
Met 210 215 220 Asp Pro Val Ile Ala Leu Met His Glu Leu Thr His Ser
Leu His Gln 225 230 235 240 Leu Tyr Gly Ile Asn Ile Pro Ser Asp Lys
Arg Ile Arg Pro Gln Val 245 250 255 Ser Glu Gly Phe Phe Ser Gln Asp
Gly Pro Asn Val Gln Phe Glu Glu 260 265 270 Leu Tyr Thr Phe Gly Gly
Leu Asp Val Glu Ile Ile Pro Gln Ile Glu 275 280 285 Arg Ser Gln Leu
Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala 290 295 300 Lys Arg
Leu Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser 305 310 315
320 Asn Ile Asp Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp
325 330 335 Lys Asp Asn Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe
Asn Ser 340 345 350 Leu Tyr Ser Asp Leu Thr Asn Val Met Ser Glu Val
Val Tyr Ser Ser 355 360 365 Gln Tyr Asn Val Lys Asn Arg Thr His Tyr
Phe Ser Arg His Tyr Leu 370 375 380 Pro Val Phe Ala Asn Ile Leu Asp
Asp Asn Ile Tyr Thr Ile Arg Asp 385 390 395 400 Gly Phe Asn Leu Thr
Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln 405 410 415 Asn Ile Glu
Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val 420 425 430 Val
Asp Leu Phe Thr Lys Val Cys Val Asp Gly Gly Gly Gly Ser Ala 435 440
445 Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu
450 455 460 Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val 485 490 495 Lys Asn Asn Arg Leu Pro Tyr Val Ala
Asp Lys Asp Ser Ile Ser Gln 500 505 510 Glu Ile Phe Glu Asn Lys Ile
Ile Thr Asp Glu Thr Asn Val Gln Asn 515 520 525 Tyr Ser Asp Lys Phe
Ser Leu Asp Glu Ser Ile Leu Asp Gly Gln Val 530 535 540 Pro Ile Asn
Pro Glu Ile Val Asp Pro Leu Leu Pro Asn Val Asn Met 545 550 555 560
Glu Pro Leu Asn Leu Pro Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile 565
570 575 Thr Lys Tyr Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser
Gln 580 585 590 Lys Leu Ser Asn Asn Val Glu Asn Ile Thr Leu Thr Thr
Ser Val Glu 595 600 605 Glu Ala Leu Gly Tyr Ser Asn Lys Ile Tyr Thr
Phe Leu Pro Ser Leu 610 615 620 Ala Glu Lys Val Asn Lys Gly Val Gln
Ala Gly Leu Phe Leu Asn Trp 625 630 635 640 Ala Asn Glu Val Val Glu
Asp Phe Thr Thr Asn Ile Met Lys Lys Asp 645 650 655 Thr Leu Asp Lys
Ile Ser Asp Val Ser Val Ile Ile Pro Tyr Ile Gly 660 665 670 Pro Ala
Leu Asn Ile Gly Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln 675 680 685
Ala Phe Ala Thr Ala Gly Val Ala Phe Leu Leu Glu Gly Phe Pro Glu 690
695 700 Phe Thr Ile Pro Ala Leu Gly Val Phe Thr Phe Tyr Ser Ser Ile
Gln 705 710 715 720 Glu Arg Glu Lys Ile Ile Lys Thr Ile Glu Asn Cys
Leu Glu Gln Arg 725 730
735 Val Lys Arg Trp Lys Asp Ser Tyr Gln Trp Met Val Ser Asn Trp Leu
740 745 750 Ser Arg Ile Thr Thr Gln Phe Asn His Ile Asn Tyr Gln Met
Tyr Asp 755 760 765 Ser Leu Ser Tyr Gln Ala Asp Ala Ile Lys Ala Lys
Ile Asp Leu Glu 770 775 780 Tyr Lys Lys Tyr Ser Gly Ser Asp Lys Glu
Asn Ile Lys Ser Gln Val 785 790 795 800 Glu Asn Leu Lys Asn Ser Leu
Asp Val Lys Ile Ser Glu Ala Met Asn 805 810 815 Asn Ile Asn Lys Phe
Ile Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys 820 825 830 Asn Met Leu
Pro Lys Val Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg 835 840 845 Thr
Lys Thr Glu Leu Ile Asn Leu Ile Asp Ser His Asn Ile Ile Leu 850 855
860 Val Gly Glu Val Asp Arg Leu Lys Ala Lys Val Asn Glu Ser Phe Glu
865 870 875 880 Asn Thr Met Pro Phe Asn Ile Phe Ser Tyr Thr Asn Asn
Ser Leu Leu 885 890 895 Lys Asp Ile Ile Asn Glu Tyr Phe Asn Leu Glu
Ala Leu Ala Ser Gly 900 905 910 His His His His His His 915
29907PRTArtificial SequenceSynthetic sequence 29Met Gly Ser Met Thr
Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro 1 5 10 15 Val Asn Asp
Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu 20 25 30 Ile
Thr Thr Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val 35 40
45 Ile Pro Glu Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro
50 55 60 Pro Arg Pro Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser
Tyr Leu 65 70 75 80 Ser Thr Asp Glu Gln Lys Asp Thr Phe Leu Lys Gly
Ile Ile Lys Leu 85 90 95 Phe Lys Arg Ile Asn Glu Arg Asp Ile Gly
Lys Lys Leu Ile Asn Tyr 100 105 110 Leu Val Val Gly Ser Pro Phe Met
Gly Asp Ser Ser Thr Pro Glu Asp 115 120 125 Thr Phe Asp Phe Thr Arg
His Thr Thr Asn Ile Ala Val Glu Lys Phe 130 135 140 Glu Asn Gly Ser
Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val Leu 145 150 155 160 Ile
Phe Gly Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr 165 170
175 Leu Gln Gly Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu
180 185 190 Ser Ile Leu Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser
Asp Val 195 200 205 Thr Ser Asn Gln Ser Ser Ala Val Leu Gly Lys Ser
Ile Phe Cys Met 210 215 220 Asp Pro Val Ile Ala Leu Met His Glu Leu
Thr His Ser Leu His Gln 225 230 235 240 Leu Tyr Gly Ile Asn Ile Pro
Ser Asp Lys Arg Ile Arg Pro Gln Val 245 250 255 Ser Glu Gly Phe Phe
Ser Gln Asp Gly Pro Asn Val Gln Phe Glu Glu 260 265 270 Leu Tyr Thr
Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile Glu 275 280 285 Arg
Ser Gln Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala 290 295
300 Lys Arg Leu Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser
305 310 315 320 Asn Ile Asp Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr
Asn Phe Asp 325 330 335 Lys Asp Asn Thr Gly Asn Phe Val Val Asn Ile
Asp Lys Phe Asn Ser 340 345 350 Leu Tyr Ser Asp Leu Thr Asn Val Met
Ser Glu Val Val Tyr Ser Ser 355 360 365 Gln Tyr Asn Val Lys Asn Arg
Thr His Tyr Phe Ser Arg His Tyr Leu 370 375 380 Pro Val Phe Ala Asn
Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp 385 390 395 400 Gly Phe
Asn Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln 405 410 415
Asn Ile Glu Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val 420
425 430 Val Asp Leu Phe Thr Lys Val Cys Val Asp Gly Gly Gly Gly Ser
Ala 435 440 445 Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly
Tyr Leu Leu 450 455 460 Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly
Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser Ala
Leu Val Leu Gln Cys Ile Lys Val 485 490 495 Lys Asn Asn Arg Leu Pro
Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln 500 505 510 Glu Ile Phe Glu
Asn Lys Ile Ile Thr Asp Glu Thr Asn Val Gln Asn 515 520 525 Tyr Ser
Asp Lys Phe Ser Leu Asp Glu Ser Ile Leu Asp Gly Gln Val 530 535 540
Pro Ile Asn Pro Glu Ile Val Asp Pro Leu Leu Pro Asn Val Asn Met 545
550 555 560 Glu Pro Leu Asn Leu Pro Gly Glu Glu Ile Val Phe Tyr Asp
Asp Ile 565 570 575 Thr Lys Tyr Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr
Leu Glu Ser Gln 580 585 590 Lys Leu Ser Asn Asn Val Glu Asn Ile Thr
Leu Thr Thr Ser Val Glu 595 600 605 Glu Ala Leu Gly Tyr Ser Asn Lys
Ile Tyr Thr Phe Leu Pro Ser Leu 610 615 620 Ala Glu Lys Val Asn Lys
Gly Val Gln Ala Gly Leu Phe Leu Asn Trp 625 630 635 640 Ala Asn Glu
Val Val Glu Asp Phe Thr Thr Asn Ile Met Lys Lys Asp 645 650 655 Thr
Leu Asp Lys Ile Ser Asp Val Ser Val Ile Ile Pro Tyr Ile Gly 660 665
670 Pro Ala Leu Asn Ile Gly Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln
675 680 685 Ala Phe Ala Thr Ala Gly Val Ala Phe Leu Leu Glu Gly Phe
Pro Glu 690 695 700 Phe Thr Ile Pro Ala Leu Gly Val Phe Thr Phe Tyr
Ser Ser Ile Gln 705 710 715 720 Glu Arg Glu Lys Ile Ile Lys Thr Ile
Glu Asn Cys Leu Glu Gln Arg 725 730 735 Val Lys Arg Trp Lys Asp Ser
Tyr Gln Trp Met Val Ser Asn Trp Leu 740 745 750 Ser Arg Ile Thr Thr
Gln Phe Asn His Ile Asn Tyr Gln Met Tyr Asp 755 760 765 Ser Leu Ser
Tyr Gln Ala Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu 770 775 780 Tyr
Lys Lys Tyr Ser Gly Ser Asp Lys Glu Asn Ile Lys Ser Gln Val 785 790
795 800 Glu Asn Leu Lys Asn Ser Leu Asp Val Lys Ile Ser Glu Ala Met
Asn 805 810 815 Asn Ile Asn Lys Phe Ile Arg Glu Cys Ser Val Thr Tyr
Leu Phe Lys 820 825 830 Asn Met Leu Pro Lys Val Ile Asp Glu Leu Asn
Lys Phe Asp Leu Arg 835 840 845 Thr Lys Thr Glu Leu Ile Asn Leu Ile
Asp Ser His Asn Ile Ile Leu 850 855 860 Val Gly Glu Val Asp Arg Leu
Lys Ala Lys Val Asn Glu Ser Phe Glu 865 870 875 880 Asn Thr Met Pro
Phe Asn Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu 885 890 895 Lys Asp
Ile Ile Asn Glu Tyr Phe Asn Leu Asp 900 905 302766DNAArtificial
SequenceSynthetic sequence 30catatgggat ccatggagtt cgttaacaaa
cagttcaact ataaagaccc agttaacggt 60gttgacattg cttacatcaa aatcccgaac
gctggccaga tgcagccggt aaaggcattc 120aaaatccaca acaaaatctg
ggttatcccg gaacgtgata cctttactaa cccggaagaa 180ggtgacctga
acccgccacc ggaagcgaaa caggtgccgg tatcttacta tgactccacc
240tacctgtcta ccgataacga aaaggacaac tacctgaaag gtgttactaa
actgttcgag 300cgtatttact ccaccgacct gggccgtatg ctgctgacta
gcatcgttcg cggtatcccg 360ttctggggcg gttctaccat cgataccgaa
ctgaaagtaa tcgacactaa ctgcatcaac 420gttattcagc cggacggttc
ctatcgttcc gaagaactga acctggtgat catcggcccg 480tctgctgata
tcatccagtt cgagtgtaag agctttggtc acgaagttct gaacctcacc
540cgtaacggct acggttccac tcagtacatc cgtttctctc cggacttcac
cttcggtttt 600gaagaatccc tggaagtaga cacgaaccca ctgctgggcg
ctggtaaatt cgcaactgat 660cctgcggtta ccctggctca cgaactgatt
catgcaggcc accgcctgta cggtatcgcc 720atcaatccga accgtgtctt
caaagttaac accaacgcgt attacgagat gtccggtctg 780gaagttagct
tcgaagaact gcgtactttt ggcggtcacg acgctaaatt catcgactct
840ctgcaagaaa acgagttccg tctgtactac tataacaagt tcaaagatat
cgcatccacc 900ctgaacaaag cgaaatccat cgtgggtacc actgcttctc
tccagtacat gaagaacgtt 960tttaaagaaa aatacctgct cagcgaagac
acctccggca aattctctgt agacaagttg 1020aaattcgata aactttacaa
aatgctgact gaaatttaca ccgaagacaa cttcgttaag 1080ttctttaaag
ttctgaaccg caaaacctat ctgaacttcg acaaggcagt attcaaaatc
1140aacatcgtgc cgaaagttaa ctacactatc tacgatggtt tcaacctgcg
taacaccaac 1200ctggctgcta attttaacgg ccagaacacg gaaatcaaca
acatgaactt cacaaaactg 1260aaaaacttca ctggtctgtt cgagttttac
aagctgctgt gcgtcgacgg cggtggcggt 1320agcgcagacg atgacgataa
aggttggacc ctgaactctg ctggttacct gctgggtccg 1380cacgctgttg
cgctagcggc tgaagctgct gctaaagaag ctgctgctaa agaagctgct
1440gctaaagctg gtggcggtgg ttccgcacta gtgctgcagt gtatcaaggt
taacaactgg 1500gatttattct tcagcccgag tgaagacaac ttcaccaacg
acctgaacaa aggtgaagaa 1560atcacctcag atactaacat cgaagcagcc
gaagaaaaca tctcgctgga cctgatccag 1620cagtactacc tgacctttaa
tttcgacaac gagccggaaa acatttctat cgaaaacctg 1680agctctgata
tcatcggcca gctggaactg atgccgaaca tcgaacgttt cccaaacggt
1740aaaaagtacg agctggacaa atataccatg ttccactacc tgcgcgcgca
ggaatttgaa 1800cacggcaaat cccgtatcgc actgactaac tccgttaacg
aagctctgct caacccgtcc 1860cgtgtataca ccttcttctc tagcgactac
gtgaaaaagg tcaacaaagc gactgaagct 1920gcaatgttct tgggttgggt
tgaacagctt gtttatgatt ttaccgacga gacgtccgaa 1980gtatctacta
ccgacaaaat tgcggatatc actatcatca tcccgtacat cggtccggct
2040ctgaacattg gcaacatgct gtacaaagac gacttcgttg gcgcactgat
cttctccggt 2100gcggtgatcc tgctggagtt catcccggaa atcgccatcc
cggtactggg cacctttgct 2160ctggtttctt acattgcaaa caaggttctg
actgtacaaa ccatcgacaa cgcgctgagc 2220aaacgtaacg aaaaatggga
tgaagtttac aaatatatcg tgaccaactg gctggctaag 2280gttaatactc
agatcgacct catccgcaaa aaaatgaaag aagcactgga aaaccaggcg
2340gaagctacca aggcaatcat taactaccag tacaaccagt acaccgagga
agaaaaaaac 2400aacatcaact tcaacatcga cgatctgtcc tctaaactga
acgaatccat caacaaagct 2460atgatcaaca tcaacaagtt cctgaaccag
tgctctgtaa gctatctgat gaactccatg 2520atcccgtacg gtgttaaacg
tctggaggac ttcgatgcgt ctctgaaaga cgccctgctg 2580aaatacattt
acgacaaccg tggcactctg atcggtcagg ttgatcgtct gaaggacaaa
2640gtgaacaata ccttatcgac cgacatccct tttcagctca gtaaatatgt
cgataaccaa 2700cgccttttgt ccactctaga agcactagcg agtgggcacc
atcaccatca ccattaatga 2760aagctt 276631917PRTArtificial
SequenceSynthetic sequence 31Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440
445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu
450 455 460 Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala
Ala Ala 465 470 475 480 Lys Ala Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val 485 490 495 Asn Asn Trp Asp Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn 500 505 510 Asp Leu Asn Lys Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala 515 520 525 Ala Glu Glu Asn Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 530 535 540 Phe Asn Phe
Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser 545 550 555 560
Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe 565
570 575 Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His
Tyr 580 585 590 Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile
Ala Leu Thr 595 600 605 Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser
Arg Val Tyr Thr Phe 610 615 620 Phe Ser Ser Asp Tyr Val Lys Lys Val
Asn Lys Ala Thr Glu Ala Ala 625 630 635 640 Met Phe Leu Gly Trp Val
Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu 645 650 655 Thr Ser Glu Val
Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile 660 665 670 Ile Pro
Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys 675 680 685
Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu 690
695 700 Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala
Leu 705 710 715 720 Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln
Thr Ile Asp Asn 725 730 735 Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp
Glu Val Tyr Lys Tyr Ile 740 745 750 Val Thr Asn Trp Leu Ala Lys Val
Asn Thr Gln Ile Asp Leu Ile Arg 755 760
765 Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala
770 775 780 Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys
Asn Asn 785 790 795 800 Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys
Leu Asn Glu Ser Ile 805 810 815 Asn Lys Ala Met Ile Asn Ile Asn Lys
Phe Leu Asn Gln Cys Ser Val 820 825 830 Ser Tyr Leu Met Asn Ser Met
Ile Pro Tyr Gly Val Lys Arg Leu Glu 835 840 845 Asp Phe Asp Ala Ser
Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp 850 855 860 Asn Arg Gly
Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val 865 870 875 880
Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val 885
890 895 Asp Asn Gln Arg Leu Leu Ser Thr Leu Glu Ala Leu Ala Ser Gly
His 900 905 910 His His His His His 915 32906PRTArtificial
SequenceSynthetic sequence 32Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440
445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu
450 455 460 Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala
Ala Ala 465 470 475 480 Lys Ala Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val 485 490 495 Asn Asn Trp Asp Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn 500 505 510 Asp Leu Asn Lys Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala 515 520 525 Ala Glu Glu Asn Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 530 535 540 Phe Asn Phe
Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser 545 550 555 560
Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe 565
570 575 Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His
Tyr 580 585 590 Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile
Ala Leu Thr 595 600 605 Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser
Arg Val Tyr Thr Phe 610 615 620 Phe Ser Ser Asp Tyr Val Lys Lys Val
Asn Lys Ala Thr Glu Ala Ala 625 630 635 640 Met Phe Leu Gly Trp Val
Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu 645 650 655 Thr Ser Glu Val
Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile 660 665 670 Ile Pro
Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys 675 680 685
Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu 690
695 700 Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala
Leu 705 710 715 720 Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln
Thr Ile Asp Asn 725 730 735 Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp
Glu Val Tyr Lys Tyr Ile 740 745 750 Val Thr Asn Trp Leu Ala Lys Val
Asn Thr Gln Ile Asp Leu Ile Arg 755 760 765 Lys Lys Met Lys Glu Ala
Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala 770 775 780 Ile Ile Asn Tyr
Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn 785 790 795 800 Ile
Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile 805 810
815 Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val
820 825 830 Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg
Leu Glu 835 840 845 Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys
Tyr Ile Tyr Asp 850 855 860 Asn Arg Gly Thr Leu Ile Gly Gln Val Asp
Arg Leu Lys Asp Lys Val 865 870 875 880 Asn Asn Thr Leu Ser Thr Asp
Ile Pro Phe Gln Leu Ser Lys Tyr Val 885 890 895 Asp Asn Gln Arg Leu
Leu Ser Thr Leu Asp 900 905 33915PRTArtificial SequenceSynthetic
sequence 33Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys
Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His
Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn
Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp
Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe
Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110
Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115
120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile
Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser
Phe Gly His Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly
Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly
Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His
Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235
240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met
245 250 255 Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly
Gly His 260 265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu
Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser
Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser
Leu Gln Tyr Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu
Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr
Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360
365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys
370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr
Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile
Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu
Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Asp Asp 435 440 445 Asp Asp Lys Gly Trp
Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro 450 455 460 His Ala Val
Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480
Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn 485
490 495 Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp
Leu 500 505 510 Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu
Ala Ala Glu 515 520 525 Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr
Tyr Leu Thr Phe Asn 530 535 540 Phe Asp Asn Glu Pro Glu Asn Ile Ser
Ile Glu Asn Leu Ser Ser Asp 545 550 555 560 Ile Ile Gly Gln Leu Glu
Leu Met Pro Asn Ile Glu Arg Phe Pro Asn 565 570 575 Gly Lys Lys Tyr
Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg 580 585 590 Ala Gln
Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 595 600 605
Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 610
615 620 Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met
Phe 625 630 635 640 Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr
Asp Glu Thr Ser 645 650 655 Glu Val Ser Thr Thr Asp Lys Ile Ala Asp
Ile Thr Ile Ile Ile Pro 660 665 670 Tyr Ile Gly Pro Ala Leu Asn Ile
Gly Asn Met Leu Tyr Lys Asp Asp 675 680 685 Phe Val Gly Ala Leu Ile
Phe Ser Gly Ala Val Ile Leu Leu Glu Phe 690 695 700 Ile Pro Glu Ile
Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser 705 710 715 720 Tyr
Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 725 730
735 Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr
740 745 750 Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg
Lys Lys 755 760 765 Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr
Lys Ala Ile Ile 770 775 780 Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu
Glu Lys Asn Asn Ile Asn 785 790 795 800 Phe Asn Ile Asp Asp Leu Ser
Ser Lys Leu Asn Glu Ser Ile Asn Lys 805 810 815 Ala Met Ile Asn Ile
Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr 820 825 830 Leu Met Asn
Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe 835 840 845 Asp
Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg 850 855
860 Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn
865 870 875 880 Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr
Val Asp Asn 885 890 895 Gln Arg Leu Leu Ser Thr Leu Glu Ala Leu Ala
Ser Gly His His His 900 905 910 His His His 915 34904PRTArtificial
SequenceSynthetic sequence 34Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305
310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe
Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu
Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys
Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val
Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr
Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn
Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr
Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425
430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Asp
435 440 445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu
Gly Pro 450 455 460 His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly Gly Ser Ala Leu Val Leu
Gln Cys Ile Lys Val Asn Asn 485 490 495 Trp Asp Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp Leu 500 505 510 Asn Lys Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu 515 520 525 Glu Asn Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn 530 535 540 Phe
Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp 545 550
555 560 Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro
Asn 565 570 575 Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His
Tyr Leu Arg 580 585 590 Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile
Ala Leu Thr Asn Ser 595 600 605 Val Asn Glu Ala Leu Leu Asn Pro Ser
Arg Val Tyr Thr Phe Phe Ser 610 615 620 Ser Asp Tyr Val Lys Lys Val
Asn Lys Ala Thr Glu Ala Ala Met Phe 625 630 635 640 Leu Gly Trp Val
Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser 645 650 655 Glu Val
Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro 660 665 670
Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp 675
680 685 Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu
Phe 690 695 700 Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala
Leu Val Ser 705 710 715 720 Tyr Ile Ala Asn Lys Val Leu Thr Val Gln
Thr Ile Asp Asn Ala Leu 725 730 735 Ser Lys Arg Asn Glu Lys Trp Asp
Glu Val Tyr Lys Tyr Ile Val Thr 740 745 750 Asn Trp Leu Ala Lys Val
Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 755 760 765 Met Lys Glu Ala
Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile 770 775 780 Asn Tyr
Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn 785 790 795
800 Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys
805 810 815 Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val
Ser Tyr 820 825 830 Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg
Leu Glu Asp Phe 835 840 845 Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys
Tyr Ile Tyr Asp Asn Arg 850 855 860 Gly Thr Leu Ile Gly Gln Val Asp
Arg Leu Lys Asp Lys Val Asn Asn 865 870 875 880 Thr Leu Ser Thr Asp
Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn 885 890 895 Gln Arg Leu
Leu Ser Thr Leu Asp 900 35905PRTArtificial SequenceSynthetic
sequence 35Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys
Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His
Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn
Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp
Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe
Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110
Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115
120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile
Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser
Phe Gly His Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly
Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly
Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His
Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235
240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met
245 250 255 Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly
Gly His 260 265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu
Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser
Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser
Leu Gln Tyr Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu
Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr
Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360
365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys
370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr
Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile
Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu
Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly
Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440 445 Thr Leu Asn Ser Ala
Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu 450 455 460 Ala Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu Gln 465 470 475 480
Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp 485
490 495 Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp
Thr 500 505 510 Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu
Ile Gln Gln 515 520 525 Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro
Glu Asn Ile Ser Ile 530 535 540 Glu Asn Leu Ser Ser Asp Ile Ile Gly
Gln Leu Glu Leu Met Pro Asn 545 550 555 560 Ile Glu Arg Phe Pro Asn
Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr 565 570 575 Met Phe His Tyr
Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg 580 585 590 Ile Ala
Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg 595 600 605
Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala 610
615 620 Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr
Asp 625 630 635 640 Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp
Lys Ile Ala Asp 645 650 655 Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro
Ala Leu Asn Ile Gly Asn 660 665 670 Met Leu Tyr Lys Asp Asp Phe Val
Gly Ala Leu Ile Phe Ser Gly Ala 675 680 685 Val Ile Leu Leu Glu Phe
Ile Pro Glu Ile Ala Ile Pro Val Leu Gly 690 695 700 Thr Phe Ala Leu
Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln 705 710 715 720 Thr
Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val 725 730
735 Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile
740 745 750 Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln
Ala Glu 755 760 765 Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln
Tyr Thr Glu Glu 770 775 780 Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp
Asp Leu Ser Ser Lys Leu 785 790 795 800 Asn Glu Ser Ile Asn Lys Ala
Met Ile Asn Ile Asn Lys Phe Leu Asn 805 810 815 Gln Cys Ser Val Ser
Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val 820 825 830 Lys Arg Leu
Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys 835 840 845 Tyr
Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu 850 855
860 Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu
865 870 875 880 Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu
Glu Ala Leu 885 890 895 Ala Ser Gly His His His His His His 900 905
36894PRTArtificial SequenceSynthetic sequence 36Met Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met
Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40
45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser
Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170
175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser
180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp
Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295
300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420
425 430 Cys Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly
Trp 435 440 445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala
Val Ala Leu 450 455 460 Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Leu Val Leu Gln 465 470 475 480 Cys Ile Lys Val Asn Asn Trp Asp
Leu Phe Phe Ser Pro Ser Glu Asp 485 490 495 Asn Phe Thr Asn Asp Leu
Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr 500 505 510 Asn Ile Glu Ala
Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln 515 520 525 Tyr Tyr
Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile 530 535 540
Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn 545
550 555 560 Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys
Tyr Thr 565 570 575 Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His
Gly Lys Ser Arg 580 585 590 Ile Ala Leu Thr Asn Ser Val Asn Glu Ala
Leu Leu Asn Pro Ser Arg 595 600 605 Val Tyr Thr Phe Phe Ser Ser Asp
Tyr Val Lys Lys Val Asn Lys Ala 610 615 620 Thr Glu Ala Ala Met Phe
Leu Gly Trp Val Glu Gln Leu Val Tyr Asp 625 630 635 640 Phe Thr Asp
Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp 645 650 655 Ile
Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn 660 665
670 Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala
675 680 685 Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val
Leu Gly 690 695 700 Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val
Leu Thr Val Gln 705 710 715 720 Thr Ile Asp Asn Ala Leu Ser Lys Arg
Asn Glu Lys Trp Asp Glu Val 725 730 735 Tyr Lys Tyr Ile Val Thr Asn
Trp Leu Ala Lys Val Asn Thr Gln Ile 740 745 750 Asp Leu Ile Arg Lys
Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu 755 760 765 Ala Thr Lys
Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu 770 775 780 Glu
Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 785
790
795 800 Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu
Asn 805 810 815 Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro
Tyr Gly Val 820 825 830 Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys
Asp Ala Leu Leu Lys 835 840 845 Tyr Ile Tyr Asp Asn Arg Gly Thr Leu
Ile Gly Gln Val Asp Arg Leu 850 855 860 Lys Asp Lys Val Asn Asn Thr
Leu Ser Thr Asp Ile Pro Phe Gln Leu 865 870 875 880 Ser Lys Tyr Val
Asp Asn Gln Arg Leu Leu Ser Thr Leu Asp 885 890 37900PRTArtificial
SequenceSynthetic sequence 37Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 435 440
445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu
450 455 460 Ala Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys Ile Lys
Val Asn 465 470 475 480 Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp
Asn Phe Thr Asn Asp 485 490 495 Leu Asn Lys Gly Glu Glu Ile Thr Ser
Asp Thr Asn Ile Glu Ala Ala 500 505 510 Glu Glu Asn Ile Ser Leu Asp
Leu Ile Gln Gln Tyr Tyr Leu Thr Phe 515 520 525 Asn Phe Asp Asn Glu
Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser 530 535 540 Asp Ile Ile
Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro 545 550 555 560
Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu 565
570 575 Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr
Asn 580 585 590 Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr
Thr Phe Phe 595 600 605 Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala
Thr Glu Ala Ala Met 610 615 620 Phe Leu Gly Trp Val Glu Gln Leu Val
Tyr Asp Phe Thr Asp Glu Thr 625 630 635 640 Ser Glu Val Ser Thr Thr
Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile 645 650 655 Pro Tyr Ile Gly
Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp 660 665 670 Asp Phe
Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu 675 680 685
Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val 690
695 700 Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn
Ala 705 710 715 720 Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr
Lys Tyr Ile Val 725 730 735 Thr Asn Trp Leu Ala Lys Val Asn Thr Gln
Ile Asp Leu Ile Arg Lys 740 745 750 Lys Met Lys Glu Ala Leu Glu Asn
Gln Ala Glu Ala Thr Lys Ala Ile 755 760 765 Ile Asn Tyr Gln Tyr Asn
Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile 770 775 780 Asn Phe Asn Ile
Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn 785 790 795 800 Lys
Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser 805 810
815 Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp
820 825 830 Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr
Asp Asn 835 840 845 Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys
Asp Lys Val Asn 850 855 860 Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln
Leu Ser Lys Tyr Val Asp 865 870 875 880 Asn Gln Arg Leu Leu Ser Thr
Leu Glu Ala Leu Ala Ser Gly His His 885 890 895 His His His His 900
38889PRTArtificial SequenceSynthetic sequence 38Met Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met
Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40
45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser
Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170
175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser
180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp
Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295
300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420
425 430 Cys Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly
Trp 435 440 445 Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala
Val Ala Leu 450 455 460 Ala Gly Gly Gly Gly Ser Ala Leu Val Leu Gln
Cys Ile Lys Val Asn 465 470 475 480 Asn Trp Asp Leu Phe Phe Ser Pro
Ser Glu Asp Asn Phe Thr Asn Asp 485 490 495 Leu Asn Lys Gly Glu Glu
Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala 500 505 510 Glu Glu Asn Ile
Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe 515 520 525 Asn Phe
Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser 530 535 540
Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro 545
550 555 560 Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His
Tyr Leu 565 570 575 Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile
Ala Leu Thr Asn 580 585 590 Ser Val Asn Glu Ala Leu Leu Asn Pro Ser
Arg Val Tyr Thr Phe Phe 595 600 605 Ser Ser Asp Tyr Val Lys Lys Val
Asn Lys Ala Thr Glu Ala Ala Met 610 615 620 Phe Leu Gly Trp Val Glu
Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr 625 630 635 640 Ser Glu Val
Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile 645 650 655 Pro
Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp 660 665
670 Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu
675 680 685 Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala
Leu Val 690 695 700 Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr
Ile Asp Asn Ala 705 710 715 720 Leu Ser Lys Arg Asn Glu Lys Trp Asp
Glu Val Tyr Lys Tyr Ile Val 725 730 735 Thr Asn Trp Leu Ala Lys Val
Asn Thr Gln Ile Asp Leu Ile Arg Lys 740 745 750 Lys Met Lys Glu Ala
Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile 755 760 765 Ile Asn Tyr
Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile 770 775 780 Asn
Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn 785 790
795 800 Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val
Ser 805 810 815 Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg
Leu Glu Asp 820 825 830 Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys
Tyr Ile Tyr Asp Asn 835 840 845 Arg Gly Thr Leu Ile Gly Gln Val Asp
Arg Leu Lys Asp Lys Val Asn 850 855 860 Asn Thr Leu Ser Thr Asp Ile
Pro Phe Gln Leu Ser Lys Tyr Val Asp 865 870 875 880 Asn Gln Arg Leu
Leu Ser Thr Leu Asp 885 39927PRTArtificial SequenceSynthetic
sequence 39Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys
Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro
Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His
Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn
Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp
Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe
Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110
Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115
120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile
Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser
Phe Gly His Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly
Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly
Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His
Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235
240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met
245 250 255 Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly
Gly His 260 265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu
Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser
Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser
Leu Gln Tyr Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu
Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr
Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360
365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys
370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr
Asn Leu 385 390 395 400 Ala Ala Asn
Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr
Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425
430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser
Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His Ala Val Ala Leu Ala Ala
Glu Ala Ala Ala 465 470 475 480 Lys Glu Ala Ala Ala Lys Glu Ala Ala
Ala Lys Ala Gly Gly Gly Gly 485 490 495 Ser Ala Leu Val Leu Gln Cys
Ile Lys Val Asn Asn Trp Asp Leu Phe 500 505 510 Phe Ser Pro Ser Glu
Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu 515 520 525 Glu Ile Thr
Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser 530 535 540 Leu
Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu 545 550
555 560 Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly
Gln 565 570 575 Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly
Lys Lys Tyr 580 585 590 Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu
Arg Ala Gln Glu Phe 595 600 605 Glu His Gly Lys Ser Arg Ile Ala Leu
Thr Asn Ser Val Asn Glu Ala 610 615 620 Leu Leu Asn Pro Ser Arg Val
Tyr Thr Phe Phe Ser Ser Asp Tyr Val 625 630 635 640 Lys Lys Val Asn
Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val 645 650 655 Glu Gln
Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr 660 665 670
Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro 675
680 685 Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly
Ala 690 695 700 Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile
Pro Glu Ile 705 710 715 720 Ala Ile Pro Val Leu Gly Thr Phe Ala Leu
Val Ser Tyr Ile Ala Asn 725 730 735 Lys Val Leu Thr Val Gln Thr Ile
Asp Asn Ala Leu Ser Lys Arg Asn 740 745 750 Glu Lys Trp Asp Glu Val
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala 755 760 765 Lys Val Asn Thr
Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala 770 775 780 Leu Glu
Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr 785 790 795
800 Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp
805 810 815 Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
Ile Asn 820 825 830 Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met Asn Ser 835 840 845 Met Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala Ser Leu 850 855 860 Lys Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr Leu Ile 865 870 875 880 Gly Gln Val Asp Arg
Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr 885 890 895 Asp Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu 900 905 910 Ser
Thr Leu Glu Ala Leu Ala Ser Gly His His His His His His 915 920 925
40916PRTArtificial SequenceSynthetic sequence 40Met Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met
Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40
45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser
Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170
175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser
180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp
Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295
300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420
425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn
Ser Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His Ala Val Ala Leu Ala
Ala Glu Ala Ala Ala 465 470 475 480 Lys Glu Ala Ala Ala Lys Glu Ala
Ala Ala Lys Ala Gly Gly Gly Gly 485 490 495 Ser Ala Leu Val Leu Gln
Cys Ile Lys Val Asn Asn Trp Asp Leu Phe 500 505 510 Phe Ser Pro Ser
Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu 515 520 525 Glu Ile
Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser 530 535 540
Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu 545
550 555 560 Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile
Gly Gln 565 570 575 Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn
Gly Lys Lys Tyr 580 585 590 Glu Leu Asp Lys Tyr Thr Met Phe His Tyr
Leu Arg Ala Gln Glu Phe 595 600 605 Glu His Gly Lys Ser Arg Ile Ala
Leu Thr Asn Ser Val Asn Glu Ala 610 615 620 Leu Leu Asn Pro Ser Arg
Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val 625 630 635 640 Lys Lys Val
Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val 645 650 655 Glu
Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr 660 665
670 Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro
675 680 685 Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val
Gly Ala 690 695 700 Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe
Ile Pro Glu Ile 705 710 715 720 Ala Ile Pro Val Leu Gly Thr Phe Ala
Leu Val Ser Tyr Ile Ala Asn 725 730 735 Lys Val Leu Thr Val Gln Thr
Ile Asp Asn Ala Leu Ser Lys Arg Asn 740 745 750 Glu Lys Trp Asp Glu
Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala 755 760 765 Lys Val Asn
Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala 770 775 780 Leu
Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr 785 790
795 800 Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile
Asp 805 810 815 Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala
Met Ile Asn 820 825 830 Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser
Tyr Leu Met Asn Ser 835 840 845 Met Ile Pro Tyr Gly Val Lys Arg Leu
Glu Asp Phe Asp Ala Ser Leu 850 855 860 Lys Asp Ala Leu Leu Lys Tyr
Ile Tyr Asp Asn Arg Gly Thr Leu Ile 865 870 875 880 Gly Gln Val Asp
Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr 885 890 895 Asp Ile
Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu 900 905 910
Ser Thr Leu Asp 915 41915PRTArtificial SequenceSynthetic sequence
41Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1
5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly
Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile
Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu
Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val
Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys
Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile
Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val
Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu
Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135
140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser
145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His
Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln
Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu
Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys
Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile
His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro
Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255
Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260
265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu
Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn
Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr
Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu
Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp
Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn
Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu
Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380
Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385
390 395 400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met
Asn Phe 405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe
Tyr Lys Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys
Gly Trp Thr Leu Asn Ser Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His
Ala Val Ala Leu Ala Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly
Gly Ser Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn 485 490 495 Trp
Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu 500 505
510 Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu
515 520 525 Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr
Phe Asn 530 535 540 Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn
Leu Ser Ser Asp 545 550 555 560 Ile Ile Gly Gln Leu Glu Leu Met Pro
Asn Ile Glu Arg Phe Pro Asn 565 570 575 Gly Lys Lys Tyr Glu Leu Asp
Lys Tyr Thr Met Phe His Tyr Leu Arg 580 585 590 Ala Gln Glu Phe Glu
His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 595 600 605 Val Asn Glu
Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 610 615 620 Ser
Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe 625 630
635 640 Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr
Ser 645 650 655 Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile
Ile Ile Pro 660 665 670 Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met
Leu Tyr Lys Asp Asp 675 680 685 Phe Val Gly Ala Leu Ile Phe Ser Gly
Ala Val Ile Leu Leu Glu Phe 690 695 700 Ile Pro Glu Ile Ala Ile Pro
Val Leu Gly Thr Phe Ala Leu Val Ser 705 710 715 720 Tyr Ile Ala Asn
Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 725 730 735 Ser Lys
Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr 740 745 750
Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 755
760 765 Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile
Ile 770 775 780 Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn
Asn Ile Asn 785 790 795 800 Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu
Asn Glu Ser Ile Asn Lys 805 810 815 Ala Met Ile Asn Ile Asn Lys Phe
Leu Asn Gln Cys Ser Val Ser Tyr 820 825 830 Leu Met Asn Ser Met Ile
Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe 835 840 845 Asp Ala Ser Leu
Lys Asp Ala Leu
Leu Lys Tyr Ile Tyr Asp Asn Arg 850 855 860 Gly Thr Leu Ile Gly Gln
Val Asp Arg Leu Lys Asp Lys Val Asn Asn 865 870 875 880 Thr Leu Ser
Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn 885 890 895 Gln
Arg Leu Leu Ser Thr Leu Glu Ala Leu Ala Ser Gly His His His 900 905
910 His His His 915 42904PRTArtificial SequenceSynthetic sequence
42Met Gly Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1
5 10 15 Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly
Gln 20 25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile
Trp Val Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu
Gly Asp Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val
Ser Tyr Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys
Asp Asn Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile
Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val
Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu
Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135
140 Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser
145 150 155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His
Glu Val Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln
Tyr Ile Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu
Ser Leu Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys
Phe Ala Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile
His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro
Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255
Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260
265 270 Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu
Tyr 275 280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn
Lys Ala Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr
Met Lys Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu
Asp Thr Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp
Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn
Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu
Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380
Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385
390 395 400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met
Asn Phe 405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe
Tyr Lys Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys
Gly Trp Thr Leu Asn Ser Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His
Ala Val Ala Leu Ala Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly
Gly Ser Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn 485 490 495 Trp
Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu 500 505
510 Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu
515 520 525 Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr
Phe Asn 530 535 540 Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn
Leu Ser Ser Asp 545 550 555 560 Ile Ile Gly Gln Leu Glu Leu Met Pro
Asn Ile Glu Arg Phe Pro Asn 565 570 575 Gly Lys Lys Tyr Glu Leu Asp
Lys Tyr Thr Met Phe His Tyr Leu Arg 580 585 590 Ala Gln Glu Phe Glu
His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 595 600 605 Val Asn Glu
Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 610 615 620 Ser
Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe 625 630
635 640 Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr
Ser 645 650 655 Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile
Ile Ile Pro 660 665 670 Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met
Leu Tyr Lys Asp Asp 675 680 685 Phe Val Gly Ala Leu Ile Phe Ser Gly
Ala Val Ile Leu Leu Glu Phe 690 695 700 Ile Pro Glu Ile Ala Ile Pro
Val Leu Gly Thr Phe Ala Leu Val Ser 705 710 715 720 Tyr Ile Ala Asn
Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 725 730 735 Ser Lys
Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr 740 745 750
Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 755
760 765 Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile
Ile 770 775 780 Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn
Asn Ile Asn 785 790 795 800 Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu
Asn Glu Ser Ile Asn Lys 805 810 815 Ala Met Ile Asn Ile Asn Lys Phe
Leu Asn Gln Cys Ser Val Ser Tyr 820 825 830 Leu Met Asn Ser Met Ile
Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe 835 840 845 Asp Ala Ser Leu
Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg 850 855 860 Gly Thr
Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn 865 870 875
880 Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn
885 890 895 Gln Arg Leu Leu Ser Thr Leu Asp 900 43910PRTArtificial
SequenceSynthetic sequence 43Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440
445 Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly
450 455 460 Tyr Leu Leu Gly Pro His Ala Val Ala Leu Ala Gly Gly Gly
Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn
Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu Asp Asn Phe Thr Asn
Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr Ser Asp Thr Asn Ile
Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525 Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530 535 540 Glu Asn Ile
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 545 550 555 560
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 565
570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe
Glu 580 585 590 His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn
Glu Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser
Ser Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu 625 630 635 640 Gln Leu Val Tyr Asp Phe
Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650 655 Asp Lys Ile Ala
Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 660 665 670 Leu Asn
Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 675 680 685
Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 690
695 700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys 705 710 715 720 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser
Lys Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val
Thr Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu Asn Gln Ala Glu Ala
Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775 780 Gln Tyr Thr Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 785 790 795 800 Leu
Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 805 810
815 Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
820 825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro Phe Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser 885 890 895 Thr Leu Glu Ala Leu
Ala Ser Gly His His His His His His 900 905 910 44899PRTArtificial
SequenceSynthetic sequence 44Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405
410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp Thr
Leu Asn Ser Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His Ala Val Ala
Leu Ala Gly Gly Gly Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys
Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu
Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr
Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525
Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530
535 540 Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln
Leu 545 550 555 560 Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly
Lys Lys Tyr Glu 565 570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu
Arg Ala Gln Glu Phe Glu 580 585 590 His Gly Lys Ser Arg Ile Ala Leu
Thr Asn Ser Val Asn Glu Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val
Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys
Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 625 630 635 640 Gln
Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650
655 Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala
660 665 670 Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly
Ala Leu 675 680 685 Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile
Pro Glu Ile Ala 690 695 700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val
Ser Tyr Ile Ala Asn Lys 705 710 715 720 Val Leu Thr Val Gln Thr Ile
Asp Asn Ala Leu Ser Lys Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val
Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr
Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu
Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775
780 Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
785 790 795 800 Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met
Ile Asn Ile 805 810 815 Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr
Leu Met Asn Ser Met 820 825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu
Asp Phe Asp Ala Ser Leu Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile
Tyr Asp Asn Arg Gly Thr Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro
Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 885 890 895
Thr Leu Asp 45922PRTArtificial SequenceSynthetic sequence 45Met Gly
Ser Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15
Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20
25 30 Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
Ile 35 40 45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp
Leu Asn Pro 50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr
Tyr Asp Ser Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn
Tyr Leu Lys Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser
Thr Asp Leu Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly
Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys
Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly
Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150
155 160 Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val
Leu 165 170 175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile
Arg Phe Ser 180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu
Glu Val Asp Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala
Thr Asp Pro Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala
Gly His Arg Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg
Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly
Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270
Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275
280 285 Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala
Lys 290 295 300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys
Asn Val Phe 305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr
Ser Gly Lys Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu
Tyr Lys Met Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val
Lys Phe Phe Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe
Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn
Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395
400 Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe
405 410 415 Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys
Leu Leu 420 425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Asp Asp 435 440 445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala
Gly Tyr Leu Leu Gly Pro 450 455 460 His Ala Val Ala Leu Ala Ala Glu
Ala Ala Ala Lys Glu Ala Ala Ala 465 470 475 480 Lys Glu Ala Ala Ala
Lys Ala Gly Gly Gly Gly Ser Ala Leu Val Leu 485 490 495 Gln Cys Ile
Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu 500 505 510 Asp
Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp 515 520
525 Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln
530 535 540 Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn
Ile Ser 545 550 555 560 Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln
Leu Glu Leu Met Pro 565 570 575 Asn Ile Glu Arg Phe Pro Asn Gly Lys
Lys Tyr Glu Leu Asp Lys Tyr 580 585 590 Thr Met Phe His Tyr Leu Arg
Ala Gln Glu Phe Glu His Gly Lys Ser 595 600 605 Arg Ile Ala Leu Thr
Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser 610 615 620 Arg Val Tyr
Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys 625 630 635 640
Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 645
650 655 Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile
Ala 660 665 670 Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu
Asn Ile Gly 675 680 685 Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala
Leu Ile Phe Ser Gly 690 695 700 Ala Val Ile Leu Leu Glu Phe Ile Pro
Glu Ile Ala Ile Pro Val Leu 705 710 715 720 Gly Thr Phe Ala Leu Val
Ser Tyr Ile Ala Asn Lys Val Leu Thr Val 725 730 735 Gln Thr Ile Asp
Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu 740 745 750 Val Tyr
Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln 755 760 765
Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala 770
775 780 Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr
Glu 785 790 795 800 Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser Ser Lys 805 810 815 Leu Asn Glu Ser Ile Asn Lys Ala Met Ile
Asn Ile Asn Lys Phe Leu 820 825 830 Asn Gln Cys Ser Val Ser Tyr Leu
Met Asn Ser Met Ile Pro Tyr Gly 835 840 845 Val Lys Arg Leu Glu Asp
Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu 850 855 860 Lys Tyr Ile Tyr
Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg 865 870 875 880 Leu
Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln 885 890
895 Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Glu Ala
900 905 910 Leu Ala Ser Gly His His His His His His 915 920
46911PRTArtificial SequenceSynthetic sequence 46Met Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met
Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40
45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser
Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170
175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser
180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp
Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295
300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420
425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp
Asp 435 440 445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu
Leu Gly Pro 450 455 460 His Ala Val Ala Leu Ala Ala Glu Ala Ala Ala
Lys Glu Ala Ala Ala 465 470 475 480 Lys Glu Ala Ala Ala Lys Ala Gly
Gly Gly Gly Ser Ala Leu Val Leu 485 490 495 Gln Cys Ile Lys Val Asn
Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu 500 505 510 Asp Asn Phe Thr
Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp 515 520 525 Thr Asn
Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln 530 535 540
Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser 545
550 555 560 Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu
Met Pro 565 570 575 Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu
Leu Asp Lys Tyr 580 585 590 Thr Met Phe His Tyr Leu Arg Ala Gln Glu
Phe Glu His Gly Lys Ser 595 600 605 Arg Ile Ala Leu Thr Asn Ser Val
Asn Glu Ala Leu Leu Asn Pro Ser 610 615 620 Arg Val Tyr Thr Phe Phe
Ser Ser Asp Tyr Val Lys Lys Val Asn Lys 625 630 635 640 Ala Thr Glu
Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 645 650 655 Asp
Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala 660 665
670 Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly
675 680 685 Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe
Ser Gly 690 695 700 Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala
Ile Pro Val Leu 705 710 715 720 Gly Thr Phe Ala Leu Val Ser Tyr Ile
Ala Asn Lys Val Leu Thr Val 725 730 735 Gln Thr Ile Asp Asn Ala Leu
Ser Lys Arg Asn Glu Lys Trp Asp Glu 740 745 750 Val Tyr Lys Tyr Ile
Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln 755 760 765 Ile Asp Leu
Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala 770 775 780 Glu
Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu 785 790
795 800 Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser
Lys 805 810 815 Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn
Lys Phe Leu 820 825 830 Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser
Met Ile Pro Tyr Gly 835 840 845 Val Lys Arg Leu Glu Asp Phe Asp Ala
Ser Leu Lys Asp Ala Leu Leu 850 855 860 Lys Tyr Ile Tyr Asp Asn Arg
Gly Thr Leu Ile Gly Gln Val Asp Arg 865 870 875 880 Leu Lys Asp Lys
Val Asn Asn Thr Leu Ser Thr
Asp Ile Pro Phe Gln 885 890 895 Leu Ser Lys Tyr Val Asp Asn Gln Arg
Leu Leu Ser Thr Leu Asp 900 905 910 47910PRTArtificial
SequenceSynthetic sequence 47Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Asp 435 440
445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro
450 455 460 His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn
Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu Asp Asn Phe Thr Asn
Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr Ser Asp Thr Asn Ile
Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525 Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530 535 540 Glu Asn Ile
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 545 550 555 560
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 565
570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe
Glu 580 585 590 His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn
Glu Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser
Ser Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu 625 630 635 640 Gln Leu Val Tyr Asp Phe
Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650 655 Asp Lys Ile Ala
Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 660 665 670 Leu Asn
Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 675 680 685
Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 690
695 700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys 705 710 715 720 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser
Lys Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val
Thr Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu Asn Gln Ala Glu Ala
Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775 780 Gln Tyr Thr Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 785 790 795 800 Leu
Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 805 810
815 Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
820 825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro Phe Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser 885 890 895 Thr Leu Glu Ala Leu
Ala Ser Gly His His His His His His 900 905 910 48899PRTArtificial
SequenceSynthetic sequence 48Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Asp 435 440
445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro
450 455 460 His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 465 470 475 480 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn
Trp Asp Leu Phe Phe 485 490 495 Ser Pro Ser Glu Asp Asn Phe Thr Asn
Asp Leu Asn Lys Gly Glu Glu 500 505 510 Ile Thr Ser Asp Thr Asn Ile
Glu Ala Ala Glu Glu Asn Ile Ser Leu 515 520 525 Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 530 535 540 Glu Asn Ile
Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 545 550 555 560
Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 565
570 575 Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe
Glu 580 585 590 His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn
Glu Ala Leu 595 600 605 Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser
Ser Asp Tyr Val Lys 610 615 620 Lys Val Asn Lys Ala Thr Glu Ala Ala
Met Phe Leu Gly Trp Val Glu 625 630 635 640 Gln Leu Val Tyr Asp Phe
Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 645 650 655 Asp Lys Ile Ala
Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 660 665 670 Leu Asn
Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 675 680 685
Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 690
695 700 Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn
Lys 705 710 715 720 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser
Lys Arg Asn Glu 725 730 735 Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val
Thr Asn Trp Leu Ala Lys 740 745 750 Val Asn Thr Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys Glu Ala Leu 755 760 765 Glu Asn Gln Ala Glu Ala
Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 770 775 780 Gln Tyr Thr Glu
Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 785 790 795 800 Leu
Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 805 810
815 Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met
820 825 830 Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser
Leu Lys 835 840 845 Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly
Thr Leu Ile Gly 850 855 860 Gln Val Asp Arg Leu Lys Asp Lys Val Asn
Asn Thr Leu Ser Thr Asp 865 870 875 880 Ile Pro Phe Gln Leu Ser Lys
Tyr Val Asp Asn Gln Arg Leu Leu Ser 885 890 895 Thr Leu Asp
49905PRTArtificial SequenceSynthetic sequence 49Met Gly Ser Met Glu
Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met
Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40
45 Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro
50 55 60 Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser
Thr Tyr 65 70 75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys
Gly Val Thr Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu
Gly Arg Met Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe
Trp Gly Gly Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg
Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala
Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170
175 Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser
180 185 190 Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp
Thr Asn 195 200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro
Ala Val Thr Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg
Leu Tyr Gly Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys
Val Asn Thr Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val
Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr
Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295
300 Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe
305 310 315 320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys
Phe Ser Val 325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met
Leu Thr Glu Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe
Lys Val Leu Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala
Val Phe Lys Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile
Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala
Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415
Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420
425 430 Cys Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp
Asp 435 440 445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr
Leu Leu Gly Pro 450 455 460 His Ala Val Ala Leu Ala Gly Gly Gly Gly
Ser Ala Leu Val Leu Gln 465 470 475 480 Cys Ile Lys Val Asn Asn Trp
Asp Leu Phe Phe Ser Pro Ser Glu Asp 485 490 495 Asn Phe Thr Asn Asp
Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr 500 505 510 Asn Ile Glu
Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln 515 520 525 Tyr
Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile 530 535
540 Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn
545 550 555 560 Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp
Lys Tyr Thr 565 570 575 Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu
His Gly Lys Ser Arg 580 585 590 Ile Ala Leu Thr Asn Ser Val Asn Glu
Ala Leu Leu Asn Pro Ser Arg 595 600 605 Val Tyr Thr Phe Phe Ser Ser
Asp Tyr Val Lys Lys Val Asn Lys Ala 610 615 620 Thr Glu Ala Ala Met
Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp 625 630 635 640 Phe Thr
Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp 645 650 655
Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn 660
665 670 Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly
Ala 675 680 685 Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro
Val Leu Gly 690 695 700 Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys
Val Leu Thr Val Gln 705 710 715 720 Thr Ile Asp Asn Ala Leu Ser Lys
Arg Asn Glu Lys Trp Asp Glu Val 725 730 735 Tyr Lys Tyr Ile Val Thr
Asn Trp Leu Ala Lys Val Asn Thr Gln Ile 740 745 750 Asp Leu Ile Arg
Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu 755 760 765 Ala Thr
Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu 770 775 780
Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 785
790 795 800 Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe
Leu Asn 805 810 815 Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile
Pro Tyr Gly Val 820 825 830 Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu
Lys Asp Ala Leu Leu Lys 835 840 845 Tyr Ile Tyr Asp Asn Arg Gly Thr
Leu Ile Gly Gln Val Asp Arg Leu 850 855 860 Lys Asp Lys Val Asn Asn
Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu 865 870 875 880 Ser Lys Tyr
Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Glu Ala Leu 885 890 895 Ala
Ser Gly His His His His His His 900 905 50894PRTArtificial
SequenceSynthetic sequence 50Met Gly Ser Met Glu Phe Val Asn Lys
Gln Phe Asn Tyr Lys Asp Pro 1 5 10 15 Val Asn Gly Val Asp Ile Ala
Tyr Ile Lys Ile Pro Asn Ala Gly Gln 20 25 30 Met Gln Pro Val Lys
Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile 35 40 45 Pro Glu Arg
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro 50 55 60 Pro
Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr 65 70
75 80 Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
Lys 85 90 95 Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met
Leu Leu Thr 100 105 110 Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly
Ser Thr Ile Asp Thr 115 120 125 Glu Leu Lys Val Ile Asp Thr Asn Cys
Ile Asn Val Ile Gln Pro Asp 130 135 140 Gly Ser Tyr Arg Ser Glu Glu
Leu Asn Leu Val Ile Ile Gly Pro Ser 145 150 155 160 Ala Asp Ile Ile
Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu 165 170 175 Asn Leu
Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser 180 185 190
Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn 195
200 205 Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
Leu 210 215 220 Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly
Ile Ala Ile 225 230 235 240 Asn Pro Asn Arg Val Phe Lys Val Asn Thr
Asn Ala Tyr Tyr Glu Met 245 250 255 Ser Gly Leu Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly His 260 265 270 Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr 275 280 285 Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys 290 295 300 Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe 305 310 315
320 Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val
325 330 335 Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile Tyr 340 345 350 Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys Thr 355 360 365 Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro Lys 370 375 380 Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn Leu 385 390 395 400 Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe 405 410 415 Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 420 425 430 Cys
Val Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Asp 435 440
445 Asp Asp Lys Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro
450 455 460 His Ala Val Ala Leu Ala Gly Gly Gly Gly Ser Ala Leu Val
Leu Gln 465 470 475 480 Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe
Ser Pro Ser Glu Asp 485 490 495 Asn Phe Thr Asn Asp Leu Asn Lys Gly
Glu Glu Ile Thr Ser Asp Thr 500 505 510 Asn Ile Glu Ala Ala Glu Glu
Asn Ile Ser Leu Asp Leu Ile Gln Gln 515 520 525 Tyr Tyr Leu Thr Phe
Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile 530 535 540 Glu Asn Leu
Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn 545 550 555 560
Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr 565
570 575 Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser
Arg 580 585 590 Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn
Pro Ser Arg 595 600 605 Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys
Lys Val Asn Lys Ala 610 615 620 Thr Glu Ala Ala Met Phe Leu Gly Trp
Val Glu Gln Leu Val Tyr Asp 625 630 635 640 Phe Thr Asp Glu Thr Ser
Glu Val Ser Thr Thr Asp Lys Ile Ala Asp 645 650 655 Ile Thr Ile Ile
Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn 660 665 670 Met Leu
Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala 675 680 685
Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly 690
695 700 Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val
Gln 705 710 715 720 Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys
Trp Asp Glu Val 725 730 735 Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala
Lys Val Asn Thr Gln Ile 740 745 750 Asp Leu Ile Arg Lys Lys Met Lys
Glu Ala Leu Glu Asn Gln Ala Glu 755 760 765 Ala Thr Lys Ala Ile Ile
Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu 770 775 780 Glu Lys Asn Asn
Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 785 790 795 800 Asn
Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn 805 810
815 Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val
820 825 830 Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu
Leu Lys 835 840 845 Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln
Val Asp Arg Leu 850 855 860 Lys Asp Lys Val Asn Asn Thr Leu Ser Thr
Asp Ile Pro Phe Gln Leu 865 870 875 880 Ser Lys Tyr Val Asp Asn Gln
Arg Leu Leu Ser Thr Leu Asp 885 890 512889DNAArtificial
SequenceSynthetic sequence 51ggatccttgg tacgagatga cgttgactat
caaattttcc gcgactttgc ggaaaataaa 60ggtaagtttt tcgtcggcgc cacagacctg
tccgtcaaaa ataagagagg ccagaacatc 120ggtaacgcac tgagcaacgt
ccctatgatt gattttagtg tagcggacgt taataaacgg 180attgcaaccg
tcgttgatcc gcagtatgct gtcagcgtca aacatgctaa agcggaagtt
240catacgttct attacgggca atataacggc cataacgatg tggctgataa
agaaaatgaa 300tatcgcgtgg tcgagcagaa caattacgaa ccgcacaaag
cgtggggcgc gagtaattta 360ggccgcctgg aggactataa catggcccgt
ttcaataaat tcgtgaccga ggtagcaccg 420atcgccccca cagatgctgg
tgggggcctg gatacctaca aagataaaaa ccgcttctct 480agcttcgtgc
gcattggcgc cggtcgtcag ctcgtgtacg agaagggtgt ctatcaccag
540gaaggtaatg aaaaggggta cgacctccgt gatttgtccc aggcgtatcg
ctacgctatt 600gccggaaccc cgtataaaga tattaatatc gatcaaacca
tgaataccga aggcctaatt 660ggtttcggga atcataataa gcaatatagc
gcagaagagc taaagcaggc cctcagccaa 720gatgcgttaa ccaattacgg
agtgttaggc gatagcggca gtccgctgtt tgccttcgat 780aaacagaaaa
atcaatgggt gtttctgggc acttatgatt attgggccgg atatggtaaa
840aagagctggc aggaatggaa tatttataaa aaggaattcg cagacaaaat
caagcagcat 900gacaacgcag gtacggtgaa ggggaacggc gaacatcact
ggaagacgac cggcacgaat 960agtcatatcg gatcgacggc cgttcgcctg
gcgaacaatg agggcgatgc aaacaatggg 1020caaaacgtga cctttgagga
caacggtacc ctggtcctta accagaacat aaatcagggc 1080gcgggaggct
tgttctttaa aggcgactat actgttaagg gagcaaacaa tgacatcacc
1140tggttagggg ccggtattga cgttgcggat ggaaaaaagg tggtttggca
ggttaaaaac 1200cctaacgggg accggctggc aaaaatcggc aaagggacat
tggaaattaa tggtaccggt 1260gtgaatcagg gtcagctgaa agtgggagat
gggaccgtga ttctgaacca gaaagcagac 1320gctgacaaaa aggtgcaagc
ctttagccaa gtaggaattg ttagtggtcg tggcacactc 1380gtcttgaact
caagcaacca aataaatccg gataacctgt actttggatt tcgtggcgga
1440cgcctggatg ctaacgggaa tgatctgacc tttgaacata tccgtaacgt
tgacgagggt 1500gcgcgcatag ttaatcataa tactgaccat gcatcaacta
tcaccttgac cgggaaaagt 1560ctgattacaa acccaaactc tctgtcagta
cattccatcc agaatgatta tgatgaagac 1620gattactcat actattaccg
gccgcgtaga ccaattccac aaggtaaaga tctttattac 1680aaaaattacc
gttattacgc attaaaatcc ggagggcggc tgaatgcacc tatgccggaa
1740aatggcgtgg ccgaaaacaa tgactggatt tttatgggtt atactcaaga
agaggctcgc 1800aaaaatgcaa tgaaccataa aaataaccga aggatcggtg
atttcggcgg atttttcgat 1860gaggaaaatg gtaaaggtca caatggtgcg
ctgaatctaa attttaacgg caaaagtgcc 1920cagaaacgtt tccttctgac
tggtggcgct aatctgaatg gtaaaatcag tgtgacgcag 1980ggtaacgtgc
tgctttctgg ccggccaact ccgcatgcac gtgattttgt aaataaatcg
2040agcgctcgta aagatgcgca tttttctaaa aataacgagg tcgtgtttga
agatgactgg 2100ataaatcgca cctttaaagc ggcagaaatc gcggttaatc
agagtgcgag cttttcatcg 2160ggtaggaatg tatctgatat tacagcaaac
attacagcca ctgataatgc gaaggtcaac 2220ctgggttata aaaacggtga
tgaagtttgt gttcgatcgg attacacggg ctatgttacc 2280tgcaacactg
gcaatctgtc tgataaagcg cttaactctt ttgacgccac gcgcattaac
2340gggaatgtga acctgaacca aaacgctgcc ttggtacttg gtaaggccgc
gttgtggggt 2400aaaattcagg gccagggcaa ctcccgtgtg tctctgaacc
agcactcgaa gtggcacctg 2460acgggggact cgcaggtgca caacttgtcc
ctggccgata gccatattca ccttaacaat 2520gcgtccgatg cccagtcagc
taataaatat catacgatca aaatcaatca cctctctggc 2580aacggtcact
ttcactactt aacggattta gcaaaaaact taggggataa agtcctggta
2640aaagaatcag cgagcggaca ttatcagtta catgtacaga acaaaacagg
cgagccaaat 2700caggaaggcc ttgacttatt tgatgcttca tcggtacaag
atcgttccag actgttcgtt 2760tcactcgcga atcactacgt tgatctgggt
gcgctgcgct atactataaa gacggaaaat 2820ggcataacac gcctctataa
tccctatgcc ggtaacggcc gtccggtgaa acctgctccc 2880tgcgtcgac
2889524284DNAArtificial SequenceSynthetic sequence 52ggatccttgg
tacgagatga cgttgactat caaattttcc gcgactttgc ggaaaataaa 60ggtaagtttt
tcgtcggcgc cacagacctg tccgtcaaaa ataagagagg ccagaacatc
120ggtaacgcac tgagcaacgt ccctatgatt gattttagtg tagcggacgt
taataaacgg 180attgcaaccg tcgttgatcc gcagtatgct gtcagcgtca
aacatgctaa agcggaagtt 240catacgttct attacgggca atataacggc
cataacgatg tggctgataa agaaaatgaa 300tatcgcgtgg tcgagcagaa
caattacgaa ccgcacaaag cgtggggcgc gagtaattta 360ggccgcctgg
aggactataa catggcccgt ttcaataaat tcgtgaccga ggtagcaccg
420atcgccccca cagatgctgg tgggggcctg gatacctaca aagataaaaa
ccgcttctct 480agcttcgtgc gcattggcgc cggtcgtcag ctcgtgtacg
agaagggtgt ctatcaccag 540gaaggtaatg aaaaggggta cgacctccgt
gatttgtccc aggcgtatcg ctacgctatt 600gccggaaccc cgtataaaga
tattaatatc gatcaaacca tgaataccga aggcctaatt 660ggtttcggga
atcataataa gcaatatagc gcagaagagc taaagcaggc cctcagccaa
720gatgcgttaa ccaattacgg agtgttaggc gatagcggca gtccgctgtt
tgccttcgat 780aaacagaaaa atcaatgggt gtttctgggc acttatgatt
attgggccgg atatggtaaa 840aagagctggc aggaatggaa tatttataaa
aaggaattcg cagacaaaat caagcagcat 900gacaacgcag gtacggtgaa
ggggaacggc gaacatcact ggaagacgac cggcacgaat 960agtcatatcg
gatcgacggc cgttcgcctg gcgaacaatg agggcgatgc aaacaatggg
1020caaaacgtga cctttgagga caacggtacc ctggtcctta accagaacat
aaatcagggc 1080gcgggaggct tgttctttaa aggcgactat actgttaagg
gagcaaacaa tgacatcacc 1140tggttagggg ccggtattga cgttgcggat
ggaaaaaagg tggtttggca ggttaaaaac 1200cctaacgggg accggctggc
aaaaatcggc aaagggacat tggaaattaa tggtaccggt 1260gtgaatcagg
gtcagctgaa agtgggagat gggaccgtga ttctgaacca gaaagcagac
1320gctgacaaaa aggtgcaagc ctttagccaa gtaggaattg ttagtggtcg
tggcacactc 1380gtcttgaact caagcaacca aataaatccg gataacctgt
actttggatt tcgtggcgga 1440cgcctggatg ctaacgggaa tgatctgacc
tttgaacata tccgtaacgt tgacgagggt 1500gcgcgcatag ttaatcataa
tactgaccat gcatcaacta tcaccttgac cgggaaaagt 1560ctgattacaa
acccaaactc tctgtcagta cattccatcc agaatgatta tgatgaagac
1620gattactcat actattaccg gccgcgtaga ccaattccac aaggtaaaga
tctttattac 1680aaaaattacc gttattacgc attaaaatcc ggagggcggc
tgaatgcacc tatgccggaa 1740aatggcgtgg ccgaaaacaa tgactggatt
tttatgggtt atactcaaga agaggctcgc 1800aaaaatgcaa tgaaccataa
aaataaccga aggatcggtg atttcggcgg atttttcgat 1860gaggaaaatg
gtaaaggtca caatggtgcg ctgaatctaa attttaacgg caaaagtgcc
1920cagaaacgtt tccttctgac tggtggcgct aatctgaatg gtaaaatcag
tgtgacgcag 1980ggtaacgtgc tgctttctgg ccggccaact ccgcatgcac
gtgattttgt aaataaatcg 2040agcgctcgta aagatgcgca tttttctaaa
aataacgagg tcgtgtttga agatgactgg 2100ataaatcgca cctttaaagc
ggcagaaatc gcggttaatc agagtgcgag cttttcatcg 2160ggtaggaatg
tatctgatat tacagcaaac attacagcca ctgataatgc gaaggtcaac
2220ctgggttata aaaacggtga tgaagtttgt gttcgatcgg attacacggg
ctatgttacc 2280tgcaacactg gcaatctgtc tgataaagcg cttaactctt
ttgacgccac gcgcattaac 2340gggaatgtga acctgaacca aaacgctgcc
ttggtacttg gtaaggccgc gttgtggggt 2400aaaattcagg gccagggcaa
ctcccgtgtg tctctgaacc agcactcgaa gtggcacctg 2460acgggggact
cgcaggtgca caacttgtcc ctggccgata gccatattca ccttaacaat
2520gcgtccgatg cccagtcagc taataaatat catacgatca aaatcaatca
cctctctggc 2580aacggtcact ttcactactt aacggattta gcaaaaaact
taggggataa agtcctggta 2640aaagaatcag cgagcggaca ttatcagtta
catgtacaga acaaaacagg cgagccaaat 2700caggaaggcc ttgacttatt
tgatgcttca tcggtacaag atcgttccag actgttcgtt 2760tcactcgcga
atcactacgt tgatctgggt gcgctgcgct atactataaa gacggaaaat
2820ggcataacac gcctctataa tccctatgcc ggtaacggcc gtccggtgaa
acctgctccc 2880tgcgtcgacg gcggtggcgg tagcgcagac gatgacgata
aaggttggac cctgaactct 2940gctggttacc tgctgggtcc gcacgctgtt
gcgctagcgg gcggtggcgg tagcggcggt 3000ggcggtagcg gcggtggcgg
tagcgcacta gtgctgcagt gtatcaaggt taacaactgg 3060gatttattct
tcagcccgag tgaagacaac ttcaccaacg acctgaacaa aggtgaagaa
3120atcacctcag atactaacat cgaagcagcc gaagaaaaca tctcgctgga
cctgatccag 3180cagtactacc tgacctttaa tttcgacaac gagccggaaa
acatttctat cgaaaacctg 3240agctctgata tcatcggcca gctggaactg
atgccgaaca tcgaacgttt cccaaacggt 3300aaaaagtacg agctggacaa
atataccatg ttccactacc tgcgcgcgca ggaatttgaa 3360cacggcaaat
cccgtatcgc actgactaac tccgttaacg aagctctgct caacccgtcc
3420cgtgtataca ccttcttctc tagcgactac gtgaaaaagg tcaacaaagc
gactgaagct 3480gcaatgttct tgggttgggt tgaacagctt gtttatgatt
ttaccgacga gacgtccgaa 3540gtatctacta ccgacaaaat tgcggatatc
actatcatca tcccgtacat cggtccggct 3600ctgaacattg gcaacatgct
gtacaaagac gacttcgttg gcgcactgat cttctccggt 3660gcggtgatcc
tgctggagtt catcccggaa atcgccatcc cggtactggg cacctttgct
3720ctggtttctt acattgcaaa caaggttctg actgtacaaa ccatcgacaa
cgcgctgagc 3780aaacgtaacg aaaaatggga tgaagtttac aaatatatcg
tgaccaactg gctggctaag 3840gttaatactc agatcgacct catccgcaaa
aaaatgaaag aagcactgga aaaccaggcg 3900gaagctacca aggcaatcat
taactaccag tacaaccagt acaccgagga agaaaaaaac 3960aacatcaact
tcaacatcga cgatctgtcc tctaaactga acgaatccat caacaaagct
4020atgatcaaca tcaacaagtt cctgaaccag tgctctgtaa gctatctgat
gaactccatg 4080atcccgtacg gtgttaaacg tctggaggac ttcgatgcgt
ctctgaaaga cgccctgctg 4140aaatacattt acgacaaccg tggcactctg
atcggtcagg ttgatcgtct gaaggacaaa 4200gtgaacaata ccttatcgac
cgacatccct tttcagctca gtaaatatgt cgataaccaa 4260cgccttttgt
ccactctaga ctag 4284531427PRTArtificial SequenceSynthetic sequence
53Gly Ser Leu Val Arg Asp Asp Val Asp Tyr Gln Ile Phe Arg Asp Phe 1
5 10 15 Ala Glu Asn Lys Gly Lys Phe Phe Val Gly Ala Thr Asp Leu Ser
Val 20 25 30 Lys Asn Lys Arg Gly Gln Asn Ile Gly Asn Ala Leu Ser
Asn Val Pro 35 40 45 Met Ile Asp Phe Ser Val Ala Asp Val Asn Lys
Arg Ile Ala Thr Val 50 55 60 Val Asp Pro Gln Tyr Ala Val Ser Val
Lys His Ala Lys Ala Glu Val 65 70 75 80 His Thr Phe Tyr Tyr Gly Gln
Tyr Asn Gly His Asn Asp Val Ala Asp 85 90 95 Lys Glu Asn Glu Tyr
Arg Val Val Glu Gln Asn Asn Tyr Glu Pro His 100 105 110 Lys Ala Trp
Gly Ala Ser Asn Leu Gly Arg Leu Glu Asp Tyr Asn Met 115 120 125 Ala
Arg Phe Asn Lys Phe Val Thr Glu Val Ala Pro Ile Ala Pro Thr 130 135
140 Asp Ala Gly Gly Gly Leu Asp Thr Tyr Lys Asp Lys Asn Arg Phe Ser
145 150 155 160 Ser Phe Val Arg Ile Gly Ala Gly Arg Gln Leu Val Tyr
Glu Lys Gly 165 170 175 Val Tyr His Gln Glu Gly Asn Glu Lys Gly Tyr
Asp Leu Arg Asp Leu 180 185 190 Ser Gln Ala Tyr Arg Tyr Ala Ile Ala
Gly Thr Pro Tyr Lys Asp Ile 195 200 205 Asn Ile Asp Gln Thr Met Asn
Thr Glu Gly Leu Ile Gly Phe Gly Asn 210 215 220 His Asn Lys Gln Tyr
Ser Ala Glu Glu Leu Lys Gln Ala Leu Ser Gln 225 230 235 240 Asp Ala
Leu Thr Asn Tyr Gly Val Leu Gly Asp Ser Gly Ser Pro Leu 245 250 255
Phe Ala Phe Asp Lys Gln Lys Asn Gln Trp Val Phe Leu Gly Thr Tyr 260
265 270 Asp Tyr Trp Ala Gly Tyr Gly Lys Lys Ser Trp Gln Glu Trp Asn
Ile 275 280 285 Tyr Lys Lys Glu Phe Ala Asp Lys Ile Lys Gln His Asp
Asn Ala Gly 290 295 300 Thr Val Lys Gly Asn Gly Glu His His Trp Lys
Thr Thr Gly Thr Asn 305 310 315 320 Ser His Ile Gly Ser Thr Ala Val
Arg Leu Ala Asn Asn Glu Gly Asp 325 330 335 Ala Asn Asn Gly Gln Asn
Val Thr Phe Glu Asp Asn Gly Thr Leu Val 340 345 350 Leu Asn Gln Asn
Ile Asn Gln Gly Ala Gly Gly Leu Phe Phe Lys Gly 355 360 365 Asp Tyr
Thr Val Lys Gly Ala Asn Asn Asp Ile Thr Trp Leu Gly Ala 370 375 380
Gly Ile Asp Val Ala Asp Gly Lys Lys Val Val Trp Gln Val Lys Asn 385
390 395 400 Pro Asn Gly Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu
Glu Ile 405 410 415 Asn Gly Thr Gly Val Asn Gln Gly Gln Leu Lys Val
Gly Asp Gly Thr 420 425 430 Val Ile Leu Asn Gln Lys Ala Asp Ala Asp
Lys Lys Val Gln Ala Phe 435 440 445 Ser Gln Val Gly Ile Val Ser Gly
Arg Gly Thr Leu Val Leu Asn Ser 450 455 460 Ser Asn Gln Ile Asn Pro
Asp Asn Leu Tyr Phe Gly Phe Arg Gly Gly 465 470 475 480 Arg Leu Asp
Ala Asn Gly Asn Asp Leu Thr Phe Glu His Ile Arg Asn 485 490 495 Val
Asp Glu Gly Ala Arg Ile Val Asn His Asn Thr Asp His Ala Ser 500 505
510 Thr Ile Thr Leu Thr Gly Lys Ser Leu Ile Thr Asn Pro Asn Ser Leu
515 520 525 Ser Val His Ser Ile Gln Asn Asp Tyr Asp Glu Asp Asp Tyr
Ser Tyr 530 535 540 Tyr Tyr Arg Pro Arg Arg Pro Ile Pro Gln Gly Lys
Asp Leu Tyr Tyr 545 550 555 560 Lys Asn Tyr Arg Tyr Tyr Ala Leu Lys
Ser Gly Gly Arg Leu Asn Ala 565 570 575 Pro Met Pro Glu Asn Gly Val
Ala Glu Asn Asn Asp Trp Ile Phe Met 580 585 590 Gly Tyr Thr Gln Glu
Glu Ala Arg Lys Asn Ala Met Asn His Lys Asn 595 600 605 Asn Arg Arg
Ile Gly Asp Phe Gly Gly Phe Phe Asp Glu Glu Asn Gly 610 615 620 Lys
Gly His Asn Gly Ala Leu Asn Leu Asn Phe Asn Gly Lys Ser Ala 625 630
635 640 Gln Lys Arg Phe Leu Leu Thr Gly Gly Ala Asn Leu Asn Gly Lys
Ile 645 650 655 Ser Val Thr Gln Gly Asn Val Leu Leu Ser Gly Arg Pro
Thr Pro His 660 665 670 Ala Arg Asp Phe Val Asn Lys Ser Ser Ala Arg
Lys Asp Ala His Phe 675 680 685 Ser Lys Asn Asn Glu Val Val Phe Glu
Asp Asp Trp Ile Asn Arg Thr 690 695 700 Phe Lys Ala Ala Glu Ile Ala
Val Asn Gln Ser Ala Ser Phe Ser Ser 705 710 715 720 Gly Arg Asn Val
Ser Asp Ile Thr Ala Asn Ile Thr Ala Thr Asp Asn 725 730 735 Ala Lys
Val Asn Leu Gly Tyr Lys Asn Gly Asp Glu Val Cys Val Arg 740 745 750
Ser Asp Tyr Thr Gly Tyr Val Thr Cys Asn Thr Gly Asn Leu Ser Asp 755
760 765 Lys Ala Leu Asn Ser Phe Asp Ala Thr Arg Ile Asn Gly Asn Val
Asn 770 775 780 Leu Asn Gln Asn Ala Ala Leu Val Leu Gly Lys Ala Ala
Leu Trp Gly 785 790 795 800 Lys Ile Gln Gly Gln Gly Asn Ser Arg Val
Ser Leu Asn Gln His Ser 805 810 815 Lys Trp His Leu Thr Gly Asp Ser
Gln Val His Asn Leu Ser Leu Ala 820 825 830 Asp Ser His Ile His Leu
Asn Asn Ala Ser Asp Ala Gln Ser Ala Asn 835 840 845 Lys Tyr His Thr
Ile Lys Ile Asn His Leu Ser Gly Asn Gly His Phe 850 855 860 His Tyr
Leu Thr Asp Leu Ala Lys Asn Leu Gly Asp Lys Val Leu Val 865 870 875
880 Lys Glu Ser Ala Ser Gly His Tyr Gln Leu His Val Gln Asn Lys Thr
885 890 895 Gly Glu Pro Asn Gln Glu Gly Leu Asp Leu Phe Asp Ala Ser
Ser Val 900 905 910 Gln Asp Arg Ser Arg Leu Phe Val Ser Leu Ala Asn
His Tyr Val Asp 915 920 925 Leu Gly Ala Leu Arg Tyr Thr Ile Lys Thr
Glu Asn Gly Ile Thr Arg 930 935 940 Leu Tyr Asn Pro Tyr Ala Gly Asn
Gly Arg Pro Val Lys Pro Ala Pro 945 950 955 960 Cys Val Asp Gly Gly
Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly Trp 965 970 975 Thr Leu Asn
Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala Leu 980 985 990 Ala
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 995
1000 1005 Ala Leu Val Leu Gln Cys Ile Lys Val Asn Asn Trp Asp Leu
Phe 1010 1015 1020 Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu
Asn Lys Gly 1025 1030 1035 Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu
Ala Ala Glu Glu Asn 1040 1045 1050 Ile Ser Leu Asp Leu Ile Gln Gln
Tyr Tyr Leu Thr Phe Asn Phe 1055 1060 1065 Asp Asn Glu Pro Glu Asn
Ile Ser Ile Glu Asn Leu Ser Ser Asp 1070 1075 1080 Ile Ile Gly Gln
Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro 1085 1090 1095 Asn Gly
Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr 1100 1105 1110
Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu 1115
1120 1125 Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val
Tyr 1130 1135 1140 Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn
Lys Ala Thr 1145 1150 1155 Glu Ala Ala Met Phe Leu Gly Trp Val Glu
Gln Leu Val Tyr Asp 1160 1165 1170 Phe Thr Asp Glu Thr Ser Glu Val
Ser Thr Thr Asp Lys Ile Ala 1175 1180 1185 Asp Ile Thr Ile Ile Ile
Pro Tyr Ile Gly Pro Ala Leu Asn Ile 1190 1195 1200 Gly Asn Met Leu
Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 1205 1210 1215 Ser Gly
Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile 1220 1225 1230
Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 1235
1240 1245 Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg
Asn 1250 1255 1260 Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr
Asn Trp Leu 1265 1270 1275 Ala Lys Val Asn Thr Gln Ile Asp Leu Ile
Arg Lys Lys Met Lys 1280 1285 1290 Glu Ala Leu Glu Asn Gln Ala Glu
Ala Thr Lys Ala Ile Ile Asn 1295 1300 1305 Tyr Gln Tyr Asn Gln Tyr
Thr Glu Glu Glu Lys Asn Asn Ile Asn 1310 1315 1320 Phe Asn Ile Asp
Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn 1325 1330 1335 Lys Ala
Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val 1340 1345 1350
Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu 1355
1360 1365 Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr
Ile 1370 1375 1380 Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp
Arg Leu Lys 1385 1390 1395 Asp Lys Val Asn Asn Thr Leu Ser Thr Asp
Ile Pro Phe Gln Leu 1400 1405 1410 Ser Lys Tyr Val Asp Asn Gln Arg
Leu Leu Ser Thr Leu Asp 1415 1420 1425 54558DNAArtificial
SequenceSynthetic sequence 54ctgcagtgta tcaatctgga ttgggacgta
atccgtgata agaccaaaac aaaaatcgag 60tctttgaaag aacacggccc gatcaaaaat
aagatgtctg aatcacccaa taaaactgtt 120tcggaggaaa aagcgaaaca
gtatttggaa gagtttcatc aaaccgcgct tgaacatccg 180gagctcagtg
aactgaaaac agtgacggga acgaatcctg tttttgcagg cgcaaactat
240gcggcttggg ccgtgaatgt tgcccaagta attgatagtg agaccgcaga
caacctggaa 300aagacgaccg cagcgttaag cattttaccg gggattggtt
ccgtgatggg tatagcggat 360ggagcggtcc accataacac tgaggaaatt
gtcgcccagt caatcgctct gagttccctg 420atggttgcac aggctatccc
actcgtgggg gaactggttg acataggttt cgccgcctac 480aacttcgtag
aaagcattat taatcttttt caggtggtgc ataacagcta caaccgccct
540ctagaatgat aaaagctt 558552010DNAArtificial SequenceSynthetic
sequence 55catatgggat ccatggagtt cgttaacaaa cagttcaact ataaagaccc
agttaacggt 60gttgacattg cttacatcaa aatcccgaac gctggccaga tgcagccggt
aaaggcattc 120aaaatccaca acaaaatctg ggttatcccg gaacgtgata
cctttactaa cccggaagaa 180ggtgacctga acccgccacc ggaagcgaaa
caggtgccgg tatcttacta tgactccacc 240tacctgtcta ccgataacga
aaaggacaac tacctgaaag gtgttactaa actgttcgag 300cgtatttact
ccaccgacct gggccgtatg ctgctgacta gcatcgttcg cggtatcccg
360ttctggggcg gttctaccat cgataccgaa ctgaaagtaa tcgacactaa
ctgcatcaac 420gttattcagc cggacggttc ctatcgttcc gaagaactga
acctggtgat catcggcccg 480tctgctgata tcatccagtt cgagtgtaag
agctttggtc acgaagttct gaacctcacc 540cgtaacggct acggttccac
tcagtacatc cgtttctctc cggacttcac cttcggtttt 600gaagaatccc
tggaagtaga cacgaaccca ctgctgggcg ctggtaaatt cgcaactgat
660cctgcggtta ccctggctca cgaactgatt catgcaggcc accgcctgta
cggtatcgcc 720atcaatccga accgtgtctt caaagttaac accaacgcgt
attacgagat gtccggtctg 780gaagttagct tcgaagaact gcgtactttt
ggcggtcacg acgctaaatt catcgactct 840ctgcaagaaa acgagttccg
tctgtactac tataacaagt tcaaagatat cgcatccacc 900ctgaacaaag
cgaaatccat cgtgggtacc actgcttctc tccagtacat gaagaacgtt
960tttaaagaaa aatacctgct cagcgaagac acctccggca aattctctgt
agacaagttg 1020aaattcgata aactttacaa aatgctgact gaaatttaca
ccgaagacaa cttcgttaag 1080ttctttaaag ttctgaaccg caaaacctat
ctgaacttcg acaaggcagt attcaaaatc 1140aacatcgtgc cgaaagttaa
ctacactatc tacgatggtt tcaacctgcg taacaccaac 1200ctggctgcta
attttaacgg ccagaacacg gaaatcaaca acatgaactt cacaaaactg
1260aaaaacttca ctggtctgtt cgagttttac aagctgctgt gcgtcgacgg
cggtggcggt 1320agcgcagacg atgacgataa aggttggacc ctgaactctg
ctggttacct gctgggtccg 1380cacgctgttg cgctagcggg cggtggcggt
agcggcggtg gcggtagcgg cggtggcggt 1440agcgcactag tgctgcagtg
tatcaatctg gattgggacg taatccgtga taagaccaaa 1500acaaaaatcg
agtctttgaa agaacacggc ccgatcaaaa ataagatgtc tgaatcaccc
1560aataaaactg tttcggagga aaaagcgaaa cagtatttgg aagagtttca
tcaaaccgcg 1620cttgaacatc cggagctcag tgaactgaaa acagtgacgg
gaacgaatcc tgtttttgca 1680ggcgcaaact atgcggcttg ggccgtgaat
gttgcccaag taattgatag tgagaccgca 1740gacaacctgg aaaagacgac
cgcagcgtta agcattttac cggggattgg ttccgtgatg 1800ggtatagcgg
atggagcggt ccaccataac actgaggaaa ttgtcgccca gtcaatcgct
1860ctgagttccc tgatggttgc acaggctatc ccactcgtgg gggaactggt
tgacataggt 1920ttcgccgcct acaacttcgt agaaagcatt attaatcttt
ttcaggtggt gcataacagc 1980tacaaccgcc ctctagaatg ataaaagctt
201056666PRTArtificial SequenceSynthetic sequence 56His Met Gly Ser
Met Glu Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp 1 5 10 15 Pro Val
Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly 20 25 30
Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val 35
40 45 Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu
Asn 50 55 60 Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr
Asp Ser Thr 65 70 75 80 Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr
Leu Lys Gly Val Thr 85 90 95 Lys Leu Phe Glu Arg Ile Tyr Ser Thr
Asp Leu Gly Arg Met Leu Leu 100 105 110 Thr Ser Ile Val Arg Gly Ile
Pro Phe Trp Gly Gly Ser Thr Ile Asp 115 120 125 Thr Glu Leu Lys Val
Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro 130 135 140 Asp Gly Ser
Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro 145 150 155 160
Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val 165
170 175 Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg
Phe 180 185 190 Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu
Val Asp Thr 195 200 205 Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr
Asp Pro Ala Val Thr 210 215 220 Leu Ala His Glu Leu Ile His Ala Gly
His Arg Leu Tyr Gly Ile Ala 225 230 235 240 Ile Asn Pro Asn Arg Val
Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu 245 250 255 Met Ser Gly Leu
Glu Val Ser Phe Glu
Glu Leu Arg Thr Phe Gly Gly 260 265 270 His Asp Ala Lys Phe Ile Asp
Ser Leu Gln Glu Asn Glu Phe Arg Leu 275 280 285 Tyr Tyr Tyr Asn Lys
Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala 290 295 300 Lys Ser Ile
Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val 305 310 315 320
Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser 325
330 335 Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu
Ile 340 345 350 Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu
Asn Arg Lys 355 360 365 Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys
Ile Asn Ile Val Pro 370 375 380 Lys Val Asn Tyr Thr Ile Tyr Asp Gly
Phe Asn Leu Arg Asn Thr Asn 385 390 395 400 Leu Ala Ala Asn Phe Asn
Gly Gln Asn Thr Glu Ile Asn Asn Met Asn 405 410 415 Phe Thr Lys Leu
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu 420 425 430 Leu Cys
Val Asp Gly Gly Gly Gly Ser Ala Asp Asp Asp Asp Lys Gly 435 440 445
Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val Ala 450
455 460 Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly 465 470 475 480 Ser Ala Leu Val Leu Gln Cys Ile Asn Leu Asp Trp
Asp Val Ile Arg 485 490 495 Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu
Lys Glu His Gly Pro Ile 500 505 510 Lys Asn Lys Met Ser Glu Ser Pro
Asn Lys Thr Val Ser Glu Glu Lys 515 520 525 Ala Lys Gln Tyr Leu Glu
Glu Phe His Gln Thr Ala Leu Glu His Pro 530 535 540 Glu Leu Ser Glu
Leu Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala 545 550 555 560 Gly
Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp 565 570
575 Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile
580 585 590 Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala
Val His 595 600 605 His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala
Leu Ser Ser Leu 610 615 620 Met Val Ala Gln Ala Ile Pro Leu Val Gly
Glu Leu Val Asp Ile Gly 625 630 635 640 Phe Ala Ala Tyr Asn Phe Val
Glu Ser Ile Ile Asn Leu Phe Gln Val 645 650 655 Val His Asn Ser Tyr
Asn Arg Pro Leu Glu 660 665 571329DNAArtificial SequenceSynthetic
sequence 57ggatccatgc ctattactat taacaatttt cgttatagcg atcccgtcaa
caatgacacc 60attatcatga tggaaccgcc atattgcaaa ggactggaca tttactataa
agccttcaag 120attactgacc gcatttggat tgttccagag cgttacgagt
tcgggacgaa accagaagat 180tttaacccgc cttcatcgct gatcgaagga
gcatcagagt attacgatcc gaactatctg 240cgtacggaca gcgataaaga
ccgcttctta cagaccatgg tcaaactttt taaccgtatt 300aagaacaatg
tggccggaga agcactcttg gataagatta tcaacgcgat tccatacctg
360ggcaattctt acagcctgct ggataaattt gacacaaata gtaattcagt
cagctttaac 420ctgttagaac aagatccgag tggcgcaacc acgaagtctg
ccatgctgac aaatctgatc 480atttttggtc caggtcctgt actgaataaa
aatgaagtac gcggcatcgt tctccgcgtg 540gacaataaga actacttccc
atgccgtgac ggcttcggtt cgatcatgca gatggctttc 600tgtccggagt
acgttccgac gtttgataat gttattgaga atatcacgag tttaacaatc
660ggtaagtcaa aatattttca agatccggcc cttctcctta tgcatgaact
gattcacgtg 720ctgcacggct tatatggtat gcaagtgtcc tcgcatgaaa
tcattccgtc caaacaggaa 780atttatatgc agcataccta cccgatttca
gctgaagagt tgtttacgtt tggtggccag 840gacgcgaatt tgatctccat
cgacatcaaa aacgatctgt atgagaaaac attaaatgac 900tataaagcga
ttgcgaacaa actgtctcag gtgactagct gcaacgatcc taacattgat
960attgattcct acaaacaaat ttatcaacag aaataccagt tcgataaaga
cagcaatggt 1020cagtatatcg taaacgaaga taaatttcag atcctgtata
acagcattat gtatggcttt 1080accgaaattg agttggggaa gaaatttaac
attaaaaccc gtctgtctta ttttagtatg 1140aaccatgatc cggtgaaaat
ccccaatctg cttgatgata ccatttataa tgataccgaa 1200gggttcaaca
ttgaatctaa ggatctgaaa tccgaataca aaggccaaaa tatgcgtgtt
1260aatactaacg ctttccgtaa tgttgatggt agtggactcg tctcgaaact
gattgggttg 1320tgtgtcgac 1329582772DNAArtificial SequenceSynthetic
sequence 58catatgggat ccatgcctat tactattaac aattttcgtt atagcgatcc
cgtcaacaat 60gacaccatta tcatgatgga accgccatat tgcaaaggac tggacattta
ctataaagcc 120ttcaagatta ctgaccgcat ttggattgtt ccagagcgtt
acgagttcgg gacgaaacca 180gaagatttta acccgccttc atcgctgatc
gaaggagcat cagagtatta cgatccgaac 240tatctgcgta cggacagcga
taaagaccgc ttcttacaga ccatggtcaa actttttaac 300cgtattaaga
acaatgtggc cggagaagca ctcttggata agattatcaa cgcgattcca
360tacctgggca attcttacag cctgctggat aaatttgaca caaatagtaa
ttcagtcagc 420tttaacctgt tagaacaaga tccgagtggc gcaaccacga
agtctgccat gctgacaaat 480ctgatcattt ttggtccagg tcctgtactg
aataaaaatg aagtacgcgg catcgttctc 540cgcgtggaca ataagaacta
cttcccatgc cgtgacggct tcggttcgat catgcagatg 600gctttctgtc
cggagtacgt tccgacgttt gataatgtta ttgagaatat cacgagttta
660acaatcggta agtcaaaata ttttcaagat ccggcccttc tccttatgca
tgaactgatt 720cacgtgctgc acggcttata tggtatgcaa gtgtcctcgc
atgaaatcat tccgtccaaa 780caggaaattt atatgcagca tacctacccg
atttcagctg aagagttgtt tacgtttggt 840ggccaggacg cgaatttgat
ctccatcgac atcaaaaacg atctgtatga gaaaacatta 900aatgactata
aagcgattgc gaacaaactg tctcaggtga ctagctgcaa cgatcctaac
960attgatattg attcctacaa acaaatttat caacagaaat accagttcga
taaagacagc 1020aatggtcagt atatcgtaaa cgaagataaa tttcagatcc
tgtataacag cattatgtat 1080ggctttaccg aaattgagtt ggggaagaaa
tttaacatta aaacccgtct gtcttatttt 1140agtatgaacc atgatccggt
gaaaatcccc aatctgcttg atgataccat ttataatgat 1200accgaagggt
tcaacattga atctaaggat ctgaaatccg aatacaaagg ccaaaatatg
1260cgtgttaata ctaacgcttt ccgtaatgtt gatggtagtg gactcgtctc
gaaactgatt 1320gggttgtgtg tcgacggcgg tggcggtagc gcagacgatg
acgataaagg ttggaccctg 1380aactctgctg gttacctgct gggtccgcac
gctgttgcgc tagcgggcgg tggcggtagc 1440ggcggtggcg gtagcggcgg
tggcggtagc gcactagtgc tgcagtgtat caaggttaac 1500aactgggatt
tattcttcag cccgagtgaa gacaacttca ccaacgacct gaacaaaggt
1560gaagaaatca cctcagatac taacatcgaa gcagccgaag aaaacatctc
gctggacctg 1620atccagcagt actacctgac ctttaatttc gacaacgagc
cggaaaacat ttctatcgaa 1680aacctgagct ctgatatcat cggccagctg
gaactgatgc cgaacatcga acgtttccca 1740aacggtaaaa agtacgagct
ggacaaatat accatgttcc actacctgcg cgcgcaggaa 1800tttgaacacg
gcaaatcccg tatcgcactg actaactccg ttaacgaagc tctgctcaac
1860ccgtcccgtg tatacacctt cttctctagc gactacgtga aaaaggtcaa
caaagcgact 1920gaagctgcaa tgttcttggg ttgggttgaa cagcttgttt
atgattttac cgacgagacg 1980tccgaagtat ctactaccga caaaattgcg
gatatcacta tcatcatccc gtacatcggt 2040ccggctctga acattggcaa
catgctgtac aaagacgact tcgttggcgc actgatcttc 2100tccggtgcgg
tgatcctgct ggagttcatc ccggaaatcg ccatcccggt actgggcacc
2160tttgctctgg tttcttacat tgcaaacaag gttctgactg tacaaaccat
cgacaacgcg 2220ctgagcaaac gtaacgaaaa atgggatgaa gtttacaaat
atatcgtgac caactggctg 2280gctaaggtta atactcagat cgacctcatc
cgcaaaaaaa tgaaagaagc actggaaaac 2340caggcggaag ctaccaaggc
aatcattaac taccagtaca accagtacac cgaggaagaa 2400aaaaacaaca
tcaacttcaa catcgacgat ctgtcctcta aactgaacga atccatcaac
2460aaagctatga tcaacatcaa caagttcctg aaccagtgct ctgtaagcta
tctgatgaac 2520tccatgatcc cgtacggtgt taaacgtctg gaggacttcg
atgcgtctct gaaagacgcc 2580ctgctgaaat acatttacga caaccgtggc
actctgatcg gtcaggttga tcgtctgaag 2640gacaaagtga acaatacctt
atcgaccgac atcccttttc agctcagtaa atatgtcgat 2700aaccaacgcc
ttttgtccac tctagaagca ctagcgagtg ggcaccatca ccatcaccat
2760taatgaaagc tt 277259920PRTArtificial SequenceSynthetic sequence
59His Met Gly Ser Met Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp 1
5 10 15 Pro Val Asn Asn Asp Thr Ile Ile Met Met Glu Pro Pro Tyr Cys
Lys 20 25 30 Gly Leu Asp Ile Tyr Tyr Lys Ala Phe Lys Ile Thr Asp
Arg Ile Trp 35 40 45 Ile Val Pro Glu Arg Tyr Glu Phe Gly Thr Lys
Pro Glu Asp Phe Asn 50 55 60 Pro Pro Ser Ser Leu Ile Glu Gly Ala
Ser Glu Tyr Tyr Asp Pro Asn 65 70 75 80 Tyr Leu Arg Thr Asp Ser Asp
Lys Asp Arg Phe Leu Gln Thr Met Val 85 90 95 Lys Leu Phe Asn Arg
Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu 100 105 110 Asp Lys Ile
Ile Asn Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu 115 120 125 Leu
Asp Lys Phe Asp Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu 130 135
140 Glu Gln Asp Pro Ser Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn
145 150 155 160 Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Asn Lys Asn
Glu Val Arg 165 170 175 Gly Ile Val Leu Arg Val Asp Asn Lys Asn Tyr
Phe Pro Cys Arg Asp 180 185 190 Gly Phe Gly Ser Ile Met Gln Met Ala
Phe Cys Pro Glu Tyr Val Pro 195 200 205 Thr Phe Asp Asn Val Ile Glu
Asn Ile Thr Ser Leu Thr Ile Gly Lys 210 215 220 Ser Lys Tyr Phe Gln
Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile 225 230 235 240 His Val
Leu His Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile 245 250 255
Ile Pro Ser Lys Gln Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser 260
265 270 Ala Glu Glu Leu Phe Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile
Ser 275 280 285 Ile Asp Ile Lys Asn Asp Leu Tyr Glu Lys Thr Leu Asn
Asp Tyr Lys 290 295 300 Ala Ile Ala Asn Lys Leu Ser Gln Val Thr Ser
Cys Asn Asp Pro Asn 305 310 315 320 Ile Asp Ile Asp Ser Tyr Lys Gln
Ile Tyr Gln Gln Lys Tyr Gln Phe 325 330 335 Asp Lys Asp Ser Asn Gly
Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln 340 345 350 Ile Leu Tyr Asn
Ser Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly 355 360 365 Lys Lys
Phe Asn Ile Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His 370 375 380
Asp Pro Val Lys Ile Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp 385
390 395 400 Thr Glu Gly Phe Asn Ile Glu Ser Lys Asp Leu Lys Ser Glu
Tyr Lys 405 410 415 Gly Gln Asn Met Arg Val Asn Thr Asn Ala Phe Arg
Asn Val Asp Gly 420 425 430 Ser Gly Leu Val Ser Lys Leu Ile Gly Leu
Cys Val Asp Gly Gly Gly 435 440 445 Gly Ser Ala Asp Asp Asp Asp Lys
Gly Trp Thr Leu Asn Ser Ala Gly 450 455 460 Tyr Leu Leu Gly Pro His
Ala Val Ala Leu Ala Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Leu Gln Cys 485 490 495 Ile
Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn 500 505
510 Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn
515 520 525 Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln
Gln Tyr 530 535 540 Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn
Ile Ser Ile Glu 545 550 555 560 Asn Leu Ser Ser Asp Ile Ile Gly Gln
Leu Glu Leu Met Pro Asn Ile 565 570 575 Glu Arg Phe Pro Asn Gly Lys
Lys Tyr Glu Leu Asp Lys Tyr Thr Met 580 585 590 Phe His Tyr Leu Arg
Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile 595 600 605 Ala Leu Thr
Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val 610 615 620 Tyr
Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr 625 630
635 640 Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp
Phe 645 650 655 Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile
Ala Asp Ile 660 665 670 Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu
Asn Ile Gly Asn Met 675 680 685 Leu Tyr Lys Asp Asp Phe Val Gly Ala
Leu Ile Phe Ser Gly Ala Val 690 695 700 Ile Leu Leu Glu Phe Ile Pro
Glu Ile Ala Ile Pro Val Leu Gly Thr 705 710 715 720 Phe Ala Leu Val
Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr 725 730 735 Ile Asp
Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr 740 745 750
Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp 755
760 765 Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu
Ala 770 775 780 Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr
Glu Glu Glu 785 790 795 800 Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp
Leu Ser Ser Lys Leu Asn 805 810 815 Glu Ser Ile Asn Lys Ala Met Ile
Asn Ile Asn Lys Phe Leu Asn Gln 820 825 830 Cys Ser Val Ser Tyr Leu
Met Asn Ser Met Ile Pro Tyr Gly Val Lys 835 840 845 Arg Leu Glu Asp
Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr 850 855 860 Ile Tyr
Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys 865 870 875
880 Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser
885 890 895 Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Leu Glu Ala
Leu Ala 900 905 910 Ser Gly His His His His His His 915 920
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