U.S. patent application number 14/326318 was filed with the patent office on 2015-06-18 for methods for correcting von willebrand factor point mutations. This patent application is currently assigned to President and Fellows of Harvard College. The applicant listed for this patent is President and Fellows of Harvard College. Invention is credited to Alexis Christine Komor, David R. Liu.
Application Number | 20150166985 14/326318 |
Document ID | / |
Family ID | 53367126 |
Filed Date | 2015-06-18 |
United States Patent Application | 20150166985 |
Kind Code | A1 |
Liu; David R. ; et al. | June 18, 2015 |
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a mutant von Willebrand Factor protein to correct a point mutation associated with a disease or disorder, e.g., with von Willebrand disease. The methods provided are useful for correcting a vWF point mutation within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
Inventors: | Liu; David R.; (Lexington, MA) ; Komor; Alexis Christine; (Pasadena, CA) | ||||||||||
Applicant: |
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Assignee: | President and Fellows of Harvard
College Cambridge MA |
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Family ID: | 53367126 | ||||||||||
Appl. No.: | 14/326318 | ||||||||||
Filed: | July 8, 2014 |
Application Number | Filing Date | Patent Number | ||
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61980333 | Apr 16, 2014 | |||
61915386 | Dec 12, 2013 | |||
Current U.S. Class: | 424/94.6 ; 435/6.11; 435/91.1 |
Current CPC Class: | C12N 9/22 20130101; C12Q 1/6883 20130101; C12Y 305/04001 20130101; A61P 17/00 20180101; C12Y 305/04 20130101; C12N 15/01 20130101; A61K 47/61 20170801; A61P 25/28 20180101; C12N 15/102 20130101; A61P 3/00 20180101; A61K 38/50 20130101; A61P 35/00 20180101; C12Y 305/04005 20130101; C12N 9/6472 20130101; C12P 19/34 20130101; A61P 25/00 20180101; A61P 19/00 20180101; C12Y 305/04004 20130101; A61K 38/465 20130101; A61P 21/00 20180101; C07K 2319/80 20130101; C12Y 301/22 20130101; C07K 2319/00 20130101; C12N 9/78 20130101; A61P 13/12 20180101; A61P 11/00 20180101; C12Y 301/00 20130101; C12Y 304/22062 20130101; A61P 13/02 20180101; C12Q 2600/156 20130101 |
International Class: | C12N 15/01 20060101 C12N015/01; C12N 9/78 20060101 C12N009/78; C12N 9/22 20060101 C12N009/22; C12P 19/34 20060101 C12P019/34; C12Q 1/68 20060101 C12Q001/68 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 92 <210> SEQ ID NO 1 <211> LENGTH: 4104
<212> TYPE: DNA <213> ORGANISM: Streptococcus pyogenes
<400> SEQUENCE: 1 atggataaga aatactcaat aggcttagat atcggcacaa
atagcgtcgg atgggcggtg 60 atcactgatg attataaggt tccgtctaaa
aagttcaagg ttctgggaaa tacagaccgc 120 cacagtatca aaaaaaatct
tataggggct cttttatttg gcagtggaga gacagcggaa 180 gcgactcgtc
tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt 240
tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga
300 cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc
tatttttgga 360 aatatagtag atgaagttgc ttatcatgag aaatatccaa
ctatctatca tctgcgaaaa 420 aaattggcag attctactga taaagcggat
ttgcgcttaa tctatttggc cttagcgcat 480 atgattaagt ttcgtggtca
ttttttgatt gagggagatt taaatcctga taatagtgat 540 gtggacaaac
tatttatcca gttggtacaa atctacaatc aattatttga agaaaaccct 600
attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga
660 cgattagaaa atctcattgc tcagctcccc ggtgagaaga gaaatggctt
gtttgggaat 720 ctcattgctt tgtcattggg attgacccct aattttaaat
caaattttga tttggcagaa 780 gatgctaaat tacagctttc aaaagatact
tacgatgatg atttagataa tttattggcg 840 caaattggag atcaatatgc
tgatttgttt ttggcagcta agaatttatc agatgctatt 900 ttactttcag
atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca 960
atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga
1020 caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa
cggatatgca 1080 ggttatattg atgggggagc tagccaagaa gaattttata
aatttatcaa accaatttta 1140 gaaaaaatgg atggtactga ggaattattg
gtgaaactaa atcgtgaaga tttgctgcgc 1200 aagcaacgga cctttgacaa
cggctctatt ccccatcaaa ttcacttggg tgagctgcat 1260 gctattttga
gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt 1320
gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt
1380 cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa
ttttgaagaa 1440 gttgtcgata aaggtgcttc agctcaatca tttattgaac
gcatgacaaa ctttgataaa 1500 aatcttccaa atgaaaaagt actaccaaaa
catagtttgc tttatgagta ttttacggtt 1560 tataacgaat tgacaaaggt
caaatatgtt actgagggaa tgcgaaaacc agcatttctt 1620 tcaggtgaac
agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc 1680
gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt
1740 tcaggagttg aagatagatt taatgcttca ttaggcgcct accatgattt
gctaaaaatt 1800 attaaagata aagatttttt ggataatgaa gaaaatgaag
atatcttaga ggatattgtt 1860 ttaacattga ccttatttga agataggggg
atgattgagg aaagacttaa aacatatgct 1920 cacctctttg atgataaggt
gatgaaacag cttaaacgtc gccgttatac tggttgggga 1980 cgtttgtctc
gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta 2040
gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat
2100 agtttgacat ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg
ccatagttta 2160 catgaacaga ttgctaactt agctggcagt cctgctatta
aaaaaggtat tttacagact 2220 gtaaaaattg ttgatgaact ggtcaaagta
atggggcata agccagaaaa tatcgttatt 2280 gaaatggcac gtgaaaatca
gacaactcaa aagggccaga aaaattcgcg agagcgtatg 2340 aaacgaatcg
aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt 2400
gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctacaaaa tggaagagac
2460 atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt
cgatcacatt 2520 gttccacaaa gtttcattaa agacgattca atagacaata
aggtactaac gcgttctgat 2580 aaaaatcgtg gtaaatcgga taacgttcca
agtgaagaag tagtcaaaaa gatgaaaaac 2640 tattggagac aacttctaaa
cgccaagtta atcactcaac gtaagtttga taatttaacg 2700 aaagctgaac
gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg 2760
gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact
2820 aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt
aaaatctaaa 2880 ttagtttctg acttccgaaa agatttccaa ttctataaag
tacgtgagat taacaattac 2940 catcatgccc atgatgcgta tctaaatgcc
gtcgttggaa ctgctttgat taagaaatat 3000 ccaaaacttg aatcggagtt
tgtctatggt gattataaag tttatgatgt tcgtaaaatg 3060 attgctaagt
ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat 3120
atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct
3180 ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg
agattttgcc 3240 acagtgcgca aagtattgtc catgccccaa gtcaatattg
tcaagaaaac agaagtacag 3300 acaggcggat tctccaagga gtcaatttta
ccaaaaagaa attcggacaa gcttattgct 3360 cgtaaaaaag actgggatcc
aaaaaaatat ggtggttttg atagtccaac ggtagcttat 3420 tcagtcctag
tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa 3480
gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt
3540 ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact
acctaaatat 3600 agtctttttg agttagaaaa cggtcgtaaa cggatgctgg
ctagtgccgg agaattacaa 3660 aaaggaaatg agctggctct gccaagcaaa
tatgtgaatt ttttatattt agctagtcat 3720 tatgaaaagt tgaagggtag
tccagaagat aacgaacaaa aacaattgtt tgtggagcag 3780 cataagcatt
atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt 3840
ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca
3900 atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct
tggagctccc 3960 gctgctttta aatattttga tacaacaatt gatcgtaaac
gatatacgtc tacaaaagaa 4020 gttttagatg ccactcttat ccatcaatcc
atcactggtc tttatgaaac acgcattgat 4080 ttgagtcagc taggaggtga ctga
4104 <210> SEQ ID NO 2 <211> LENGTH: 1367 <212>
TYPE: PRT <213> ORGANISM: Streptococcus pyogenes <400>
SEQUENCE: 2 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn
Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro
Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser
Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Gly Ser Gly
Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg
Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu
Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe
His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110
His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115
120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala
Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala
Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile
Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu
Phe Ile Gln Leu Val Gln Ile Tyr 180 185 190 Asn Gln Leu Phe Glu Glu
Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu
Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile
Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235
240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe
245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr
Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp
Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp
Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile
Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr
Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val
Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp
Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360
365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp
370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu
Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro
His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg
Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys
Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly
Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg
Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480
Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485
490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His
Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr
Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe
Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe
Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu
Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile
Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Ala Tyr
His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605
Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610
615 620 Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr
Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys
Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu
Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu
Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met
Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile
Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 705 710 715 720 His
Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730
735 Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly
740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn
Gln Thr 755 760 765 Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met
Lys Arg Ile Glu 770 775 780 Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile
Leu Lys Glu His Pro Val 785 790 795 800 Glu Asn Thr Gln Leu Gln Asn
Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 805 810 815 Asn Gly Arg Asp Met
Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 820 825 830 Ser Asp Tyr
Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 835 840 845 Asp
Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850 855
860 Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn
865 870 875 880 Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln
Arg Lys Phe 885 890 895 Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu
Ser Glu Leu Asp Lys 900 905 910 Ala Gly Phe Ile Lys Arg Gln Leu Val
Glu Thr Arg Gln Ile Thr Lys 915 920 925 His Val Ala Gln Ile Leu Asp
Ser Arg Met Asn Thr Lys Tyr Asp Glu 930 935 940 Asn Asp Lys Leu Ile
Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 945 950 955 960 Leu Val
Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 965 970 975
Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 980
985 990 Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe
Val 995 1000 1005 Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met
Ile Ala Lys 1010 1015 1020 Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala
Lys Tyr Phe Phe Tyr 1025 1030 1035 Ser Asn Ile Met Asn Phe Phe Lys
Thr Glu Ile Thr Leu Ala Asn 1040 1045 1050 Gly Glu Ile Arg Lys Arg
Pro Leu Ile Glu Thr Asn Gly Glu Thr 1055 1060 1065 Gly Glu Ile Val
Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 1070 1075 1080 Lys Val
Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu 1085 1090 1095
Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg 1100
1105 1110 Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro
Lys 1115 1120 1125 Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr
Ser Val Leu 1130 1135 1140 Val Val Ala Lys Val Glu Lys Gly Lys Ser
Lys Lys Leu Lys Ser 1145 1150 1155 Val Lys Glu Leu Leu Gly Ile Thr
Ile Met Glu Arg Ser Ser Phe 1160 1165 1170 Glu Lys Asn Pro Ile Asp
Phe Leu Glu Ala Lys Gly Tyr Lys Glu 1175 1180 1185 Val Lys Lys Asp
Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 1190 1195 1200 Glu Leu
Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 1205 1210 1215
Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn 1220
1225 1230 Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser
Pro 1235 1240 1245 Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln
His Lys His 1250 1255 1260 Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser
Glu Phe Ser Lys Arg 1265 1270 1275 Val Ile Leu Ala Asp Ala Asn Leu
Asp Lys Val Leu Ser Ala Tyr 1280 1285 1290 Asn Lys His Arg Asp Lys
Pro Ile Arg Glu Gln Ala Glu Asn Ile 1295 1300 1305 Ile His Leu Phe
Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 1310 1315 1320 Lys Tyr
Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr 1325 1330 1335
Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly 1340
1345 1350 Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp
1355 1360 1365 <210> SEQ ID NO 3 <211> LENGTH: 4212
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 3 atggataaaa agtattctat
tggtttagac atcggcacta attccgttgg atgggctgtc 60 ataaccgatg
aatacaaagt accttcaaag aaatttaagg tgttggggaa cacagaccgt 120
cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga aacggcagag
180 gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa
ccgaatatgt 240 tacttacaag aaatttttag caatgagatg gccaaagttg
acgattcttt ctttcaccgt 300 ttggaagagt ccttccttgt cgaagaggac
aagaaacatg aacggcaccc catctttgga 360 aacatagtag atgaggtggc
atatcatgaa aagtacccaa cgatttatca cctcagaaaa 420 aagctagttg
actcaactga taaagcggac ctgaggttaa tctacttggc tcttgcccat 480
atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga caactcggat
540 gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga
agagaaccct 600 ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg
cccgcctctc taaatcccga 660 cggctagaaa acctgatcgc acaattaccc
ggagagaaga aaaatgggtt gttcggtaac 720 cttatagcgc tctcactagg
cctgacacca aattttaagt cgaacttcga cttagctgaa 780 gatgccaaat
tgcagcttag taaggacacg tacgatgacg atctcgacaa tctactggca 840
caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag cgatgcaatc
900 ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt
atccgcttca 960 atgatcaaaa ggtacgatga acatcaccaa gacttgacac
ttctcaaggc cctagtccgt 1020 cagcaactgc ctgagaaata taaggaaata
ttctttgatc agtcgaaaaa cgggtacgca 1080 ggttatattg acggcggagc
gagtcaagag gaattctaca agtttatcaa acccatatta 1140 gagaagatgg
atgggacgga agagttgctt gtaaaactca atcgcgaaga tctactgcga 1200
aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg cgaattgcat
1260 gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg
tgaaaagatt 1320 gagaaaatcc taacctttcg cataccttac tatgtgggac
ccctggcccg agggaactct 1380 cggttcgcat ggatgacaag aaagtccgaa
gaaacgatta ctccatggaa ttttgaggaa 1440 gttgtcgata aaggtgcgtc
agctcaatcg ttcatcgaga ggatgaccaa ctttgacaag 1500 aatttaccga
acgaaaaagt attgcctaag cacagtttac tttacgagta tttcacagtg 1560
tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc cgcctttcta
1620 agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg
caaagtgaca 1680 gttaagcaat tgaaagagga ctactttaag aaaattgaat
gcttcgattc tgtcgagatc 1740 tccggggtag aagatcgatt taatgcgtca
cttggtacgt atcatgacct cctaaagata 1800 attaaagata aggacttcct
ggataacgaa gagaatgaag atatcttaga agatatagtg 1860 ttgactctta
ccctctttga agatcgggaa atgattgagg aaagactaaa aacatacgct 1920
cacctgttcg acgataaggt tatgaaacag ttaaagaggc gtcgctatac gggctgggga
1980 cgattgtcgc ggaaacttat caacgggata agagacaagc aaagtggtaa
aactattctc 2040 gattttctaa agagcgacgg cttcgccaat aggaacttta
tgcagctgat ccatgatgac 2100 tctttaacct tcaaagagga tatacaaaag
gcacaggttt ccggacaagg ggactcattg 2160 cacgaacata ttgcgaatct
tgctggttcg ccagccatca aaaagggcat actccagaca 2220 gtcaaagtag
tggatgagct agttaaggtc atgggacgtc acaaaccgga aaacattgta 2280
atcgagatgg cacgcgaaaa tcaaacgact cagaaggggc aaaaaaacag tcgagagcgg
2340 atgaagagaa tagaagaggg tattaaagaa ctgggcagcc agatcttaaa
ggagcatcct 2400 gtggaaaata cccaattgca gaacgagaaa ctttacctct
attacctaca aaatggaagg 2460 gacatgtatg ttgatcagga actggacata
aaccgtttat ctgattacga cgtcgatcac 2520 attgtacccc aatccttttt
gaaggacgat tcaatcgaca ataaagtgct tacacgctcg 2580 gataagaacc
gagggaaaag tgacaatgtt ccaagcgagg aagtcgtaaa gaaaatgaag 2640
aactattggc ggcagctcct aaatgcgaaa ctgataacgc aaagaaagtt cgataactta
2700 actaaagctg agaggggtgg cttgtctgaa cttgacaagg ccggatttat
taaacgtcag 2760 ctcgtggaaa cccgccaaat cacaaagcat gttgcacaga
tactagattc ccgaatgaat 2820 acgaaatacg acgagaacga taagctgatt
cgggaagtca aagtaatcac tttaaagtca 2880 aaattggtgt cggacttcag
aaaggatttt caattctata aagttaggga gataaataac 2940 taccaccatg
cgcacgacgc ttatcttaat gccgtcgtag ggaccgcact cattaagaaa 3000
tacccgaagc tagaaagtga gtttgtgtat ggtgattaca aagtttatga cgtccgtaag
3060 atgatcgcga aaagcgaaca ggagataggc aaggctacag ccaaatactt
cttttattct 3120 aacattatga atttctttaa gacggaaatc actctggcaa
acggagagat acgcaaacga 3180 cctttaattg aaaccaatgg ggagacaggt
gaaatcgtat gggataaggg ccgggacttc 3240 gcgacggtga gaaaagtttt
gtccatgccc caagtcaaca tagtaaagaa aactgaggtg 3300 cagaccggag
ggttttcaaa ggaatcgatt cttccaaaaa ggaatagtga taagctcatc 3360
gctcgtaaaa aggactggga cccgaaaaag tacggtggct tcgatagccc tacagttgcc
3420 tattctgtcc tagtagtggc aaaagttgag aagggaaaat ccaagaaact
gaagtcagtc 3480 aaagaattat tggggataac gattatggag cgctcgtctt
ttgaaaagaa ccccatcgac 3540 ttccttgagg cgaaaggtta caaggaagta
aaaaaggatc tcataattaa actaccaaag 3600 tatagtctgt ttgagttaga
aaatggccga aaacggatgt tggctagcgc cggagagctt 3660 caaaagggga
acgaactcgc actaccgtct aaatacgtga atttcctgta tttagcgtcc 3720
cattacgaga agttgaaagg ttcacctgaa gataacgaac agaagcaact ttttgttgag
3780 cagcacaaac attatctcga cgaaatcata gagcaaattt cggaattcag
taagagagtc 3840 atcctagctg atgccaatct ggacaaagta ttaagcgcat
acaacaagca cagggataaa 3900 cccatacgtg agcaggcgga aaatattatc
catttgttta ctcttaccaa cctcggcgct 3960 ccagccgcat tcaagtattt
tgacacaacg atagatcgca aacgatacac ttctaccaag 4020 gaggtgctag
acgcgacact gattcaccaa tccatcacgg gattatatga aactcggata 4080
gatttgtcac agcttggggg tgacggatcc cccaagaaga agaggaaagt ctcgagcgac
4140 tacaaagacc atgacggtga ttataaagat catgacatcg attacaagga
tgacgatgac 4200 aaggctgcag ga 4212 <210> SEQ ID NO 4
<211> LENGTH: 1368 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 4
Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5
10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys
Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys
Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala
Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr
Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser
Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu
Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg
His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His
Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135
140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp
Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln
Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile
Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg
Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu
Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile
Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255
Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260
265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala
Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu
Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala
Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His
His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln
Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys
Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu
Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380
Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385
390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile
His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp
Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys
Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala
Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu
Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp
Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn
Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505
510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys
515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly
Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn
Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe
Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val
Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu
Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu
Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu
Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630
635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg
Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly
Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu
Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile
His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala
Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile
Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu
Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750
Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755
760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg
Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys
Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys
Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val
Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val
Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile
Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys
Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875
880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys
885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu
Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr
Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg
Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu
Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp
Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn
Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val
Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995
1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile
Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys
Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr
Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro
Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp
Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu
Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val
Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110
Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115
1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser
Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys
Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile
Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe
Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu
Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu
Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu
Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230
Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235
1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His
Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu
Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp
Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro
Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr
Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe
Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys
Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350
Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355
1360 1365 <210> SEQ ID NO 5 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 5 Glu Ala Ala Ala Lys 1 5 <210> SEQ ID
NO 6 <211> LENGTH: 198 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 6 Met Asp Ser Leu Leu
Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg
Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val
Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 35 40
45 Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr
50 55 60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val
Thr Trp 65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg
His Val Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu
Arg Ile Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys
Ala Glu Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val
Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp
Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 145 150 155 160 Ala
Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170
175 Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala
180 185 190 Phe Arg Thr Leu Gly Leu 195 <210> SEQ ID NO 7
<211> LENGTH: 198 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 7 Met Asp Ser Leu Leu Met Lys
Gln Lys Lys Phe Leu Tyr His Phe Lys 1 5 10 15 Asn Val Arg Trp Ala
Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg
Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 35 40 45 Leu
Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55
60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp
65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val
Ala Glu 85 90 95 Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile
Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu
Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile
Gly Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr
Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu
Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 165 170 175 Arg
Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185
190 Phe Arg Met Leu Gly Phe 195 <210> SEQ ID NO 8 <211>
LENGTH: 198 <212> TYPE: PRT <213> ORGANISM: Canis lupus
<400> SEQUENCE: 8 Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe
Leu Tyr His Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg His
Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Ala
Thr Ser Phe Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys Ser
Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp
Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe
Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 85 90
95 Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg
100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu
Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr
Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn
Arg Glu Lys Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu His Glu
Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg Arg Ile Leu Leu
Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe Arg Thr
Leu Gly Leu 195 <210> SEQ ID NO 9 <211> LENGTH: 199
<212> TYPE: PRT <213> ORGANISM: Bos taurus <400>
SEQUENCE: 9 Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln
Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr
Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Pro Thr Ser Phe
Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys Ala Gly Cys His
Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu
Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp
Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 85 90 95 Phe Leu
Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 100 105 110
Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 115
120 125 Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys
Asp 130 135 140 Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu
Arg Thr Phe 145 150 155 160 Lys Ala Trp Glu Gly Leu His Glu Asn Ser
Val Arg Leu Ser Arg Gln 165 170 175 Leu Arg Arg Ile Leu Leu Pro Leu
Tyr Glu Val Asp Asp Leu Arg Asp 180 185 190 Ala Phe Arg Thr Leu Gly
Leu 195 <210> SEQ ID NO 10 <211> LENGTH: 429
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 10 Met Gly Pro Phe Cys Leu Gly Cys Ser His
Arg Lys Cys Tyr Ser Pro 1 5 10 15 Ile Arg Asn Leu Ile Ser Gln Glu
Thr Phe Lys Phe His Phe Lys Asn 20 25 30 Leu Gly Tyr Ala Lys Gly
Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 35 40 45 Thr Arg Lys Asp
Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 50 55 60 Lys Asn
Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 65 70 75 80
His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 85
90 95 Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln
Ile 100 105 110 Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp
Ile Phe Ser 115 120 125 Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr
Gln Gln Asn Leu Cys 130 135 140 Arg Leu Val Gln Glu Gly Ala Gln Val
Ala Ala Met Asp Leu Tyr Glu 145 150 155 160 Phe Lys Lys Cys Trp Lys
Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 165 170 175 Arg Pro Trp Lys
Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 180 185 190 Leu Gln
Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 195 200 205
Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 210
215 220 Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu
Glu 225 230 235 240 Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His
Leu Cys Tyr Tyr 245 250 255 His Arg Met Lys Pro Tyr Leu Cys Tyr Gln
Leu Glu Gln Phe Asn Gly 260 265 270 Gln Ala Pro Leu Lys Gly Cys Leu
Leu Ser Glu Lys Gly Lys Gln His 275 280 285 Ala Glu Ile Leu Phe Leu
Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 290 295 300 Val Thr Ile Thr
Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 305 310 315 320 Trp
Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 325 330
335 Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys
340 345 350 Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val
Met Asp 355 360 365 Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val
Asn Pro Lys Arg 370 375 380 Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile
Ile Ser Arg Arg Thr Gln 385 390 395 400 Arg Arg Leu Arg Arg Ile Lys
Glu Ser Trp Gly Leu Gln Asp Leu Val 405 410 415 Asn Asp Phe Gly Asn
Leu Gln Leu Gly Pro Pro Met Ser 420 425 <210> SEQ ID NO 11
<211> LENGTH: 429 <212> TYPE: PRT <213> ORGANISM:
Rattus norvegicus <400> SEQUENCE: 11 Met Gly Pro Phe Cys Leu
Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 1 5 10 15 Ile Arg Asn Leu
Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 20 25 30 Leu Arg
Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 35 40 45
Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 50
55 60 Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp
Phe 65 70 75 80 His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu
Phe Lys Ile 85 90 95 Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu
Cys Ala Glu Gln Val 100 105 110 Leu Arg Phe Leu Ala Thr His His Asn
Leu Ser Leu Asp Ile Phe Ser 115 120 125 Ser Arg Leu Tyr Asn Ile Arg
Asp Pro Glu Asn Gln Gln Asn Leu Cys 130 135 140 Arg Leu Val Gln Glu
Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 145 150 155 160 Phe Lys
Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 165 170 175
Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 180
185 190 Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser
Ser 195 200 205 Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu
Pro Glu Thr 210 215 220 Arg Phe Cys Val Glu Arg Arg Arg Val His Leu
Leu Ser Glu Glu Glu 225 230 235 240 Phe Tyr Ser Gln Phe Tyr Asn Gln
Arg Val Lys His Leu Cys Tyr Tyr 245 250 255 His Gly Val Lys Pro Tyr
Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 260 265 270 Gln Ala Pro Leu
Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 275 280 285 Ala Glu
Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 290 295 300
Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 305
310 315 320 Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile
Leu His 325 330 335 Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg
Pro Phe Gln Lys 340 345 350 Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile
Leu Val Asp Val Met Asp 355 360 365 Leu Pro Gln Phe Thr Asp Cys Trp
Thr Asn Phe Val Asn Pro Lys Arg 370 375 380 Pro Phe Trp Pro Trp Lys
Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 385 390 395 400 Arg Arg Leu
His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 405 410 415 Asn
Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 420 425 <210>
SEQ ID NO 12 <211> LENGTH: 370 <212> TYPE: PRT
<213> ORGANISM: Macaca mulatta <400> SEQUENCE: 12 Met
Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 1 5 10
15 Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val
20 25 30 Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile
Phe Gln 35 40 45 Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu
Met Arg Phe Leu 50 55 60 Arg Trp Phe His Lys Trp Arg Gln Leu His
His Asp Gln Glu Tyr Lys 65 70 75 80 Val Thr Trp Tyr Val Ser Trp Ser
Pro Cys Thr Arg Cys Ala Asn Ser 85 90 95 Val Ala Thr Phe Leu Ala
Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 100 105 110 Val Ala Arg Leu
Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 115 120 125 Arg Ile
Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 130 135 140
Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp Gly 145
150 155 160 Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro Lys His
Tyr Thr 165 170 175 Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu Arg His
Leu Met Asp Pro 180 185 190 Gly Thr Phe Thr Ser Asn Phe Asn Asn Lys
Pro Trp Val Ser Gly Gln 195 200 205 His Glu Thr Tyr Leu Cys Tyr Lys
Val Glu Arg Leu His Asn Asp Thr 210 215 220 Trp Val Pro Leu Asn Gln
His Arg Gly Phe Leu Arg Asn Gln Ala Pro 225 230 235 240 Asn Ile His
Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 245 250 255 Asp
Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr 260 265
270 Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala
275 280 285 Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys Ile Phe
Ala Ala 290 295 300 Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln Glu Gly
Leu Arg Ala Leu 305 310 315 320 His Arg Asp Gly Ala Lys Ile Ala Met
Met Asn Tyr Ser Glu Phe Glu 325 330 335 Tyr Cys Trp Asp Thr Phe Val
Asp Arg Gln Gly Arg Pro Phe Gln Pro 340 345 350 Trp Asp Gly Leu Asp
Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 355 360 365 Ala Ile 370
<210> SEQ ID NO 13 <211> LENGTH: 384 <212> TYPE:
PRT <213> ORGANISM: Pan troglodytes <400> SEQUENCE: 13
Met Lys Pro His Phe Arg Asn Pro Val Glu Arg Met Tyr Gln Asp Thr 1 5
10 15 Phe Ser Asp Asn Phe Tyr Asn Arg Pro Ile Leu Ser His Arg Asn
Thr 20 25 30 Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser
Arg Pro Pro 35 40 45 Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr
Ser Lys Leu Lys Tyr 50 55 60 His Pro Glu Met Arg Phe Phe His Trp
Phe Ser Lys Trp Arg Lys Leu 65 70 75 80 His Arg Asp Gln Glu Tyr Glu
Val Thr Trp Tyr Ile Ser Trp Ser Pro 85 90 95 Cys Thr Lys Cys Thr
Arg Asp Val Ala Thr Phe Leu Ala Glu Asp Pro 100 105 110 Lys Val Thr
Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 115 120 125 Pro
Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 130 135
140 Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys
145 150 155 160 Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu
Pro Trp Asn 165 170 175 Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile
Met Leu Gly Glu Ile 180 185 190 Leu Arg His Ser Met Asp Pro Pro Thr
Phe Thr Ser Asn Phe Asn Asn 195 200 205 Glu Leu Trp Val Arg Gly Arg
His Glu Thr Tyr Leu Cys Tyr Glu Val 210 215 220 Glu Arg Leu His Asn
Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 225 230 235 240 Phe Leu
Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 245 250 255
His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 260
265 270 Leu His Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro
Cys 275 280 285 Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Asn
Asn Lys His 290 295 300 Val Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr
Asp Asp Gln Gly Arg 305 310 315 320 Cys Gln Glu Gly Leu Arg Thr Leu
Ala Lys Ala Gly Ala Lys Ile Ser 325 330 335 Ile Met Thr Tyr Ser Glu
Phe Lys His Cys Trp Asp Thr Phe Val Asp 340 345 350 His Gln Gly Cys
Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 355 360 365 Gln Ala
Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 370 375 380
<210> SEQ ID NO 14 <211> LENGTH: 377 <212> TYPE:
PRT <213> ORGANISM: Chlorocebus sabaeus <400> SEQUENCE:
14 Met Asn Pro Gln Ile Arg Asn Met Val Glu Gln Met Glu Pro Asp Ile
1 5 10 15 Phe Val Tyr Tyr Phe Asn Asn Arg Pro Ile Leu Ser Gly Arg
Asn Thr 20 25 30 Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Asp Pro
Ser Gly Pro Pro 35 40 45 Leu Asp Ala Asn Ile Phe Gln Gly Lys Leu
Tyr Pro Glu Ala Lys Asp 50 55 60 His Pro Glu Met Lys Phe Leu His
Trp Phe Arg Lys Trp Arg Gln Leu 65 70 75 80 His Arg Asp Gln Glu Tyr
Glu Val Thr Trp Tyr Val Ser Trp Ser Pro 85 90 95 Cys Thr Arg Cys
Ala Asn Ser Val Ala Thr Phe Leu Ala Glu Asp Pro 100 105 110 Lys Val
Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Lys 115 120 125
Pro Asp Tyr Gln Gln Ala Leu Arg Ile Leu Cys Gln Glu Arg Gly Gly 130
135 140 Pro His Ala Thr Met Lys Ile Met Asn Tyr Asn Glu Phe Gln His
Cys 145 150 155 160 Trp Asn Glu Phe Val Asp Gly Gln Gly Lys Pro Phe
Lys Pro Arg Lys 165 170 175 Asn Leu Pro Lys His Tyr Thr Leu Leu His
Ala Thr Leu Gly Glu Leu 180 185 190 Leu Arg His Val Met Asp Pro Gly
Thr Phe Thr Ser Asn Phe Asn Asn 195 200 205 Lys Pro Trp Val Ser Gly
Gln Arg Glu Thr Tyr Leu Cys Tyr Lys Val 210 215 220 Glu Arg Ser His
Asn Asp Thr Trp Val Leu Leu Asn Gln His Arg Gly 225 230 235 240 Phe
Leu Arg Asn Gln Ala Pro Asp Arg His Gly Phe Pro Lys Gly Arg 245 250
255 His Ala Glu Leu Cys Phe Leu Asp Leu Ile Pro Phe Trp Lys Leu Asp
260 265 270 Asp Gln Gln Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro
Cys Phe 275 280 285 Ser Cys Ala Gln Lys Met Ala Lys Phe Ile Ser Asn
Asn Lys His Val 290 295 300 Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr
Asp Asp Gln Gly Arg Cys 305 310 315 320 Gln Glu Gly Leu Arg Thr Leu
His Arg Asp Gly Ala Lys Ile Ala Val 325 330 335 Met Asn Tyr Ser Glu
Phe Glu Tyr Cys Trp Asp Thr Phe Val Asp Arg 340 345 350 Gln Gly Arg
Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 355 360 365 Ala
Leu Ser Gly Arg Leu Arg Ala Ile 370 375 <210> SEQ ID NO 15
<211> LENGTH: 384 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 15 Met Lys Pro His Phe Arg Asn
Thr Val Glu Arg Met Tyr Arg Asp Thr 1 5 10 15 Phe Ser Tyr Asn Phe
Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 20 25 30 Val Trp Leu
Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 35 40 45 Leu
Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 50 55
60 His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu
65 70 75 80 His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp
Ser Pro 85 90 95 Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu
Ala Glu Asp Pro 100 105 110 Lys Val Thr Leu Thr Ile Phe Val Ala Arg
Leu Tyr Tyr Phe Trp Asp 115 120 125 Pro Asp Tyr Gln Glu Ala Leu Arg
Ser Leu Cys Gln Lys Arg Asp Gly 130 135 140 Pro Arg Ala Thr Met Lys
Ile Met Asn Tyr Asp Glu Phe Gln His Cys 145 150 155 160 Trp Ser Lys
Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 165 170 175 Asn
Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 180 185
190 Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn
195 200 205 Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr
Glu Val 210 215 220 Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn
Gln Arg Arg Gly 225 230 235 240 Phe Leu Cys Asn Gln Ala Pro His Lys
His Gly Phe Leu Glu Gly Arg 245 250 255 His Ala Glu Leu Cys Phe Leu
Asp Val Ile Pro Phe Trp Lys Leu Asp 260 265 270 Leu Asp Gln Asp Tyr
Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 275 280 285 Phe Ser Cys
Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 290 295 300 Val
Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 305 310
315 320 Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile
Ser 325 330 335 Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr
Phe Val Asp 340 345 350 His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly
Leu Asp Glu His Ser 355 360 365 Gln Asp Leu Ser Gly Arg Leu Arg Ala
Ile Leu Gln Asn Gln Glu Asn 370 375 380 <210> SEQ ID NO 16
<211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 16 Met Lys Pro His Phe Arg Asn
Thr Val Glu Arg Met Tyr Arg Asp Thr 1 5 10 15 Phe Ser Tyr Asn Phe
Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 20 25 30 Val Trp Leu
Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 35 40 45 Leu
Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 50 55
60 His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro
65 70 75 80 Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr
Pro Cys 85 90 95 Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala
Glu His Pro Asn 100 105 110 Val Thr Leu Thr Ile Ser Ala Ala Arg Leu
Tyr Tyr Tyr Trp Glu Arg 115 120 125 Asp Tyr Arg Arg Ala Leu Cys Arg
Leu Ser Gln Ala Gly Ala Arg Val 130 135 140 Lys Ile Met Asp Asp Glu
Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 145 150 155 160 Tyr Ser Glu
Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 165 170 175 Tyr
Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 180 185
190 Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg
195 200 205 Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met
Glu Val 210 215 220 Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly
Val Phe Arg Asn 225 230 235 240 Gln Val Asp Pro Glu Thr His Cys His
Ala Glu Arg Cys Phe Leu Ser 245 250 255 Trp Phe Cys Asp Asp Ile Leu
Ser Pro Asn Thr Asn Tyr Glu Val Thr 260 265 270 Trp Tyr Thr Ser Trp
Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 275 280 285 Glu Phe Leu
Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 290 295 300 Arg
Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 305 310
315 320 Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp
Phe 325 330 335 Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu
Pro Phe Lys 340 345 350 Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe
Leu Asp Ser Lys Leu 355 360 365 Gln Glu Ile Leu Glu 370 <210>
SEQ ID NO 17 <211> LENGTH: 382 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 Met Asn
Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 1 5 10 15
Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 20
25 30 Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn
Leu 35 40 45 Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe
Lys Pro Gln 50 55 60 Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe
Cys Gly Asn Gln Leu 65 70 75 80 Pro Ala Tyr Lys Cys Phe Gln Ile Thr
Trp Phe Val Ser Trp Thr Pro 85 90 95 Cys Pro Asp Cys Val Ala Lys
Leu Ala Glu Phe Leu Ser Glu His Pro 100 105 110 Asn Val Thr Leu Thr
Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 115 120 125 Arg Asp Tyr
Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 130 135 140 Val
Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 145 150
155 160 Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp
Glu 165 170 175 Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu
Arg Tyr Leu 180 185 190 Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn
Asn Asp Pro Leu Val 195 200 205 Leu Arg Arg Arg Gln Thr Tyr Leu Cys
Tyr Glu Val Glu Arg Leu Asp 210 215 220 Asn Gly Thr Trp Val Leu Met
Asp Gln His Met Gly Phe Leu Cys Asn 225 230 235 240 Glu Ala Lys Asn
Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 245 250 255 Arg Phe
Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 260 265 270
Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 275
280 285 Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val
Arg 290 295 300 Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro
Leu Tyr Lys 305 310 315 320 Glu Ala Leu Gln Met Leu Arg Asp Ala Gly
Ala Gln Val Ser Ile Met 325 330 335 Thr Tyr Asp Glu Phe Glu Tyr Cys
Trp Asp Thr Phe Val Tyr Arg Gln 340 345 350 Gly Cys Pro Phe Gln Pro
Trp Asp Gly Leu Glu Glu His Ser Gln Ala 355 360 365 Leu Ser Gly Arg
Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 370 375 380 <210> SEQ
ID NO 18 <211> LENGTH: 190 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Asn Pro Gln Ile
Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 1 5 10 15 Phe Tyr Phe
Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 20 25 30 Thr
Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 35 40
45 Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His
50 55 60 Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp
Ile Leu 65 70 75 80 Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr
Ser Trp Ser Pro 85 90 95 Cys Pro Asp Cys Ala Gly Glu Val Ala Glu
Phe Leu Ala Arg His Ser 100 105 110 Asn Val Asn Leu Thr Ile Phe Thr
Ala Arg Leu Tyr Tyr Phe Gln Tyr 115 120 125 Pro Cys Tyr Gln Glu Gly
Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 130 135 140 Val Glu Ile Met
Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 145 150 155 160 Val
Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 165 170
175 Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 180 185
190 <210> SEQ ID NO 19 <211> LENGTH: 199 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
19 Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His
1 5 10 15 Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys
Thr Tyr 20 25 30 Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr
Ser Val Lys Met 35 40 45 Asp Gln His Arg Gly Phe Leu His Asn Gln
Ala Lys Asn Leu Leu Cys 50 55 60 Gly Phe Tyr Gly Arg His Ala Glu
Leu Arg Phe Leu Asp Leu Val Pro 65 70 75 80 Ser Leu Gln Leu Asp Pro
Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 85 90 95 Ser Trp Ser Pro
Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 100 105 110 Phe Leu
Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 115 120 125
Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 130
135 140 Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys
His 145 150 155 160 Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro
Phe Gln Pro Trp 165 170 175 Asp Gly Leu Asp Glu His Ser Gln Ala Leu
Ser Gly Arg Leu Arg Ala 180 185 190 Ile Leu Gln Asn Gln Gly Asn 195
<210> SEQ ID NO 20 <211> LENGTH: 200 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 Met
Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 1 5 10
15 Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr
20 25 30 Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr
Phe Glu 35 40 45 Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile
Asn Glu Ile Lys 50 55 60 Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr
Gln Val Thr Cys Tyr Leu 65 70 75 80 Thr Trp Ser Pro Cys Ser Ser Cys
Ala Trp Glu Leu Val Asp Phe Ile 85 90 95 Lys Ala His Asp His Leu
Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 100 105 110 Tyr His Trp Cys
Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 115 120 125 Ser Gln
Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 130 135 140
Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 145
150 155 160 Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys
Arg Arg 165 170 175 Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln
Gly Arg Tyr Met 180 185 190 Asp Ile Leu Cys Asp Ala Glu Val 195 200
<210> SEQ ID NO 21 <211> LENGTH: 386 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 Met
Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 1 5 10
15 Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr
20 25 30 Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser
Asn Leu 35 40 45 Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu
Pro Lys Arg Gln 50 55 60 Ser Asn His Arg Gln Glu Val Tyr Phe Arg
Phe Glu Asn His Ala Glu 65 70 75 80 Met Cys Phe Leu Ser Trp Phe Cys
Gly Asn Arg Leu Pro Ala Asn Arg 85 90 95 Arg Phe Gln Ile Thr Trp
Phe Val Ser Trp Asn Pro Cys Leu Pro Cys 100 105 110 Val Val Lys Val
Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu 115 120 125 Thr Ile
Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 130 135 140
Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 145
150 155 160 Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys
Asn Glu 165 170 175 Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp
Asn Tyr Ala Ser 180 185 190 Leu His Arg Thr Leu Lys Glu Ile Leu Arg
Asn Pro Met Glu Ala Met 195 200 205 Tyr Pro His Ile Phe Tyr Phe His
Phe Lys Asn Leu Leu Lys Ala Cys 210 215 220 Gly Arg Asn Glu Ser Trp
Leu Cys Phe Thr Met Glu Val Thr Lys His 225 230 235 240 His Ser Ala
Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp 245 250 255 Pro
Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 260 265
270 Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr
275 280 285 Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu
Phe Leu 290 295 300 Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr
Ala Arg Leu Cys 305 310 315 320 Tyr Phe Trp Asp Thr Asp Tyr Gln Glu
Gly Leu Cys Ser Leu Ser Gln 325 330 335 Glu Gly Ala Ser Val Lys Ile
Met Gly Tyr Lys Asp Phe Val Ser Cys 340 345 350 Trp Lys Asn Phe Val
Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys 355 360 365 Gly Leu Gln
Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile 370 375 380 Leu
Gln 385 <210> SEQ ID NO 22 <211> LENGTH: 236
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 22 Met Thr Ser Glu Lys Gly Pro Ser Thr Gly
Asp Pro Thr Leu Arg Arg 1 5 10 15 Arg Ile Glu Pro Trp Glu Phe Asp
Val Phe Tyr Asp Pro Arg Glu Leu 20 25 30 Arg Lys Glu Ala Cys Leu
Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 35 40 45 Lys Ile Trp Arg
Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 50 55 60 Asn Phe
Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 65 70 75 80
Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 85
90 95 Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr
Leu 100 105 110 Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln
Gln Asn Arg 115 120 125 Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val
Thr Ile Gln Ile Met 130 135 140 Arg Ala Ser Glu Tyr Tyr His Cys Trp
Arg Asn Phe Val Asn Tyr Pro 145 150 155 160 Pro Gly Asp Glu Ala His
Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 165 170 175 Leu Tyr Ala Leu
Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 180 185 190 Leu Lys
Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 195 200 205
His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 210
215 220 Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 225 230 235
<210> SEQ ID NO 23 <211> LENGTH: 229 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 23 Met
Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 1 5 10
15 Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu
20 25 30 Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly
Arg His 35 40 45 Ser Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn
His Val Glu Val 50 55 60 Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg
Tyr Phe Arg Pro Asn Thr 65 70 75 80 Arg Cys Ser Ile Thr Trp Phe Leu
Ser Trp Ser Pro Cys Gly Glu Cys 85 90 95 Ser Arg Ala Ile Thr Glu
Phe Leu Ser Arg His Pro Tyr Val Thr Leu 100 105 110 Phe Ile Tyr Ile
Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 115 120 125 Gln Gly
Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 130 135 140
Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 145
150 155 160 Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp
Val Lys 165 170 175 Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly
Leu Pro Pro Cys 180 185 190 Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln
Leu Thr Phe Phe Thr Ile 195 200 205 Thr Leu Gln Thr Cys His Tyr Gln
Arg Ile Pro Pro His Leu Leu Trp 210 215 220 Ala Thr Gly Leu Lys 225
<210> SEQ ID NO 24 <211> LENGTH: 229 <212> TYPE:
PRT <213> ORGANISM: Rattus norvegicus <400> SEQUENCE:
24 Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg
1 5 10 15 Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg
Glu Leu 20 25 30 Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp
Gly Gly Arg His 35 40 45 Ser Ile Trp Arg His Thr Ser Gln Asn Thr
Asn Lys His Val Glu Val 50 55 60 Asn Phe Ile Glu Lys Phe Thr Thr
Glu Arg Tyr Phe Cys Pro Asn Thr 65 70 75 80 Arg Cys Ser Ile Thr Trp
Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 85 90 95 Ser Arg Ala Ile
Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 100 105 110 Phe Ile
Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 115 120 125
Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 130
135 140 Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr
Ser 145 150 155 160 Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His
Leu Trp Val Arg 165 170 175 Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile
Leu Gly Leu Pro Pro Cys 180 185 190 Leu Asn Ile Leu Arg Arg Lys Gln
Pro Gln Leu Thr Phe Phe Thr Ile 195 200 205 Ala Leu Gln Ser Cys His
Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 210 215 220 Ala Thr Gly Leu
Lys 225 <210> SEQ ID NO 25 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 25 Met Glu Ala Lys Ala Ala Pro Lys Pro Ala
Ala Ser Gly Ala Cys Ser 1 5 10 15 Val Ser Ala Glu Glu Thr Glu Lys
Trp Met Glu Glu Ala Met His Met 20 25 30 Ala Lys Glu Ala Leu Glu
Asn Thr Glu Val Pro Val Gly Cys Leu Met 35 40 45 Val Tyr Asn Asn
Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn Gln 50 55 60 Thr Lys
Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val 65 70 75 80
Leu Asp Trp Cys Arg Gln Ser Gly Lys Ser Pro Ser Glu Val Phe Glu 85
90 95 His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala
Ala 100 105 110 Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly
Cys Gln Asn 115 120 125 Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn
Ile Ala Ser Ala Asp 130 135 140 Leu Pro Asn Thr Gly Arg Pro Phe Gln
Cys Ile Pro Gly Tyr Arg Ala 145 150 155 160 Glu Glu Ala Val Glu Met
Leu Lys Thr Phe Tyr Lys Gln Glu Asn Pro 165 170 175 Asn Ala Pro Lys
Ser Lys Val Arg Lys Lys Glu Cys Gln Lys Ser 180 185 190 <210>
SEQ ID NO 26 <211> LENGTH: 191 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 26 Met Glu
Glu Lys Val Glu Ser Thr Thr Thr Pro Asp Gly Pro Cys Val 1 5 10 15
Val Ser Val Gln Glu Thr Glu Lys Trp Met Glu Glu Ala Met Arg Met 20
25 30 Ala Lys Glu Ala Leu Glu Asn Ile Glu Val Pro Val Gly Cys Leu
Met 35 40 45 Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu
Val Asn Gln 50 55 60 Thr Lys Asn Ala Thr Arg His Ala Glu Met Val
Ala Ile Asp Gln Val 65 70 75 80 Leu Asp Trp Cys His Gln His Gly Gln
Ser Pro Ser Thr Val Phe Glu 85 90 95 His Thr Val Leu Tyr Val Thr
Val Glu Pro Cys Ile Met Cys Ala Ala 100 105 110 Ala Leu Arg Leu Met
Lys Ile Pro Leu Val Val Tyr Gly Cys Gln Asn 115 120 125 Glu Arg Phe
Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala Asp 130 135 140 Leu
Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg Ala 145 150
155 160 Glu Glu Ala Val Glu Leu Leu Lys Thr Phe Tyr Lys Gln Glu Asn
Pro 165 170 175 Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Asp Cys Gln
Lys Ser 180 185 190 <210> SEQ ID NO 27 <211> LENGTH:
499 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 27 Met Trp Thr Ala Asp Glu Ile Ala Gln Leu
Cys Tyr Ala His Tyr Asn 1 5 10 15 Val Arg Leu Pro Lys Gln Gly Lys
Pro Glu Pro Asn Arg Glu Trp Thr 20 25 30 Leu Leu Ala Ala Val Val
Lys Ile Gln Ala Ser Ala Asn Gln Ala Cys 35 40 45 Asp Ile Pro Glu
Lys Glu Val Gln Val Thr Lys Glu Val Val Ser Met 50 55 60 Gly Thr
Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Glu Ser Gly 65 70 75 80
Asp Ile Leu Asn Asp Ser His Ala Glu Ile Ile Ala Arg Arg Ser Phe 85
90 95 Gln Arg Tyr Leu Leu His Gln Leu His Leu Ala Ala Val Leu Lys
Glu 100 105 110 Asp Ser Ile Phe Val Pro Gly Thr Gln Arg Gly Leu Trp
Arg Leu Arg 115 120 125 Pro Asp Leu Ser Phe Val Phe Phe Ser Ser His
Thr Pro Cys Gly Asp 130 135 140 Ala Ser Ile Ile Pro Met Leu Glu Phe
Glu Glu Gln Pro Cys Cys Pro 145 150 155 160 Val Ile Arg Ser Trp Ala
Asn Asn Ser Pro Val Gln Glu Thr Glu Asn 165 170 175 Leu Glu Asp Ser
Lys Asp Lys Arg Asn Cys Glu Asp Pro Ala Ser Pro 180 185 190 Val Ala
Lys Lys Met Arg Leu Gly Thr Pro Ala Arg Ser Leu Ser Asn 195 200 205
Cys Val Ala His His Gly Thr Gln Glu Ser Gly Pro Val Lys Pro Asp 210
215 220 Val Ser Ser Ser Asp Leu Thr Lys Glu Glu Pro Asp Ala Ala Asn
Gly 225 230 235 240 Ile Ala Ser Gly Ser Phe Arg Val Val Asp Val Tyr
Arg Thr Gly Ala 245 250 255 Lys Cys Val Pro Gly Glu Thr Gly Asp Leu
Arg Glu Pro Gly Ala Ala 260 265 270 Tyr His Gln Val Gly Leu Leu Arg
Val Lys Pro Gly Arg Gly Asp Arg 275 280 285 Thr Cys Ser Met Ser Cys
Ser Asp Lys Met Ala Arg Trp Asn Val Leu 290 295 300 Gly Cys Gln Gly
Ala Leu Leu Met His Phe Leu Glu Lys Pro Ile Tyr 305 310 315 320 Leu
Ser Ala Val Val Ile Gly Lys Cys Pro Tyr Ser Gln Glu Ala Met 325 330
335 Arg Arg Ala Leu Thr Gly Arg Cys Glu Glu Thr Leu Val Leu Pro Arg
340 345 350 Gly Phe Gly Val Gln Glu Leu Glu Ile Gln Gln Ser Gly Leu
Leu Phe 355 360 365 Glu Gln Ser Arg Cys Ala Val His Arg Lys Arg Gly
Asp Ser Pro Gly 370 375 380 Arg Leu Val Pro Cys Gly Ala Ala Ile Ser
Trp Ser Ala Val Pro Gln 385 390 395 400 Gln Pro Leu Asp Val Thr Ala
Asn Gly Phe Pro Gln Gly Thr Thr Lys 405 410 415 Lys Glu Ile Gly Ser
Pro Arg Ala Arg Ser Arg Ile Ser Lys Val Glu 420 425 430 Leu Phe Arg
Ser Phe Gln Lys Leu Leu Ser Ser Ile Ala Asp Asp Glu 435 440 445 Gln
Pro Asp Ser Ile Arg Val Thr Lys Lys Leu Asp Thr Tyr Gln Glu 450 455
460 Tyr Lys Asp Ala Ala Ser Ala Tyr Gln Glu Ala Trp Gly Ala Leu Arg
465 470 475 480 Arg Ile Gln Pro Phe Ala Ser Trp Ile Arg Asn Pro Pro
Asp Tyr His 485 490 495 Gln Phe Lys <210> SEQ ID NO 28
<211> LENGTH: 502 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 28 Met Trp Thr Ala Asp Glu Ile
Ala Gln Leu Cys Tyr Glu His Tyr Gly 1 5 10 15 Ile Arg Leu Pro Lys
Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr 20 25 30 Leu Leu Ala
Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys 35 40 45 Asp
Thr Pro Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met 50 55
60 Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly
65 70 75 80 Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg
Ser Phe 85 90 95 Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala
Thr Leu Lys Glu 100 105 110 Asp Ser Ile Phe Val Pro Gly Thr Gln Lys
Gly Val Trp Lys Leu Arg 115 120 125 Arg Asp Leu Ile Phe Val Phe Phe
Ser Ser His Thr Pro Cys Gly Asp 130 135 140 Ala Ser Ile Ile Pro Met
Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro 145 150 155 160 Val Phe Arg
Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn 165 170 175 Leu
Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro 180 185
190 Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val
195 200 205 Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys
Ser Gly 210 215 220 Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr
Val Glu Gly Leu 225 230 235 240 Ala Thr Val Thr Arg Ile Ala Pro Gly
Ser Ala Lys Val Ile Asp Val 245 250 255 Tyr Arg Thr Gly Ala Lys Cys
Val Pro Gly Glu Ala Gly Asp Ser Gly 260 265 270 Lys Pro Gly Ala Ala
Phe His Gln Val Gly Leu Leu Arg Val Lys Pro 275 280 285 Gly Arg Gly
Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 290 295 300 Arg
Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu 305 310
315 320 Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro
Tyr 325 330 335 Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys
Gln Asn Val 340 345 350 Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu
Leu Lys Ile Leu Gln 355 360 365 Ser Asp Leu Leu Phe Glu Gln Ser Arg
Ser Ala Val Gln Ala Lys Arg 370 375 380 Ala Asp Ser Pro Gly Arg Leu
Val Pro Cys Gly Ala Ala Ile Ser Trp 385 390 395 400 Ser Ala Val Pro
Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro 405 410 415 Gln Gly
Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln 420 425 430
Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg 435
440 445 Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu
Asp 450 455 460 Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln
Glu Ala Trp 465 470 475 480 Ser Thr Leu Arg Lys Gln Val Phe Gly Ser
Trp Ile Arg Asn Pro Pro 485 490 495 Asp Tyr His Gln Phe Lys 500
<210> SEQ ID NO 29 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 29 Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 1 5 10
<210> SEQ ID NO 30 <211> LENGTH: 1580 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 30 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr
Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr
Tyr Leu Cys Asp Lys 20 25 30 Lys Tyr Ser Ile Gly Leu Ala Ile Gly
Thr Asn Ser Val Gly Trp Ala 35 40 45 Val Ile Thr Asp Glu Tyr Lys
Val Pro Ser Lys Lys Phe Lys Val Leu 50 55 60 Gly Asn Thr Asp Arg
His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 65 70 75 80 Leu Phe Asp
Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 85 90 95 Ala
Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 100 105
110 Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His
115 120 125 Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His
Glu Arg 130 135 140 His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala
Tyr His Glu Lys 145 150 155 160 Tyr Pro Thr Ile Tyr His Leu Arg Lys
Lys Leu Val Asp Ser Thr Asp 165 170 175 Lys Ala Asp Leu Arg Leu Ile
Tyr Leu Ala Leu Ala His Met Ile Lys 180 185 190 Phe Arg Gly His Phe
Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 195 200 205 Asp Val Asp
Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 210 215 220 Phe
Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 225 230
235 240 Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile
Ala 245 250 255 Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn
Leu Ile Ala 260 265 270 Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser
Asn Phe Asp Leu Ala 275 280 285 Glu Asp Ala Lys Leu Gln Leu Ser Lys
Asp Thr Tyr Asp Asp Asp Leu 290 295 300 Asp Asn Leu Leu Ala Gln Ile
Gly Asp Gln Tyr Ala Asp Leu Phe Leu 305 310 315 320 Ala Ala Lys Asn
Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 325 330 335 Val Asn
Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 340 345 350
Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 355
360 365 Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln
Ser 370 375 380 Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser
Gln Glu Glu 385 390 395 400 Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu
Lys Met Asp Gly Thr Glu 405 410 415 Glu Leu Leu Val Lys Leu Asn Arg
Glu Asp Leu Leu Arg Lys Gln Arg 420 425 430 Thr Phe Asp Asn Gly Ser
Ile Pro His Gln Ile His Leu Gly Glu Leu 435 440 445 His Ala Ile Leu
Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 450 455 460 Asn Arg
Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 465 470 475
480 Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg
485 490 495 Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val
Val Asp 500 505 510 Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met
Thr Asn Phe Asp 515 520 525 Lys Asn Leu Pro Asn Glu Lys Val Leu Pro
Lys His Ser Leu Leu Tyr 530 535 540 Glu Tyr Phe Thr Val Tyr Asn Glu
Leu Thr Lys Val Lys Tyr Val Thr 545 550 555 560 Glu Gly Met Arg Lys
Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 565 570 575 Ile Val Asp
Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 580 585 590 Leu
Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 595 600
605 Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His
610 615 620 Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn
Glu Glu 625 630 635 640 Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr
Leu Thr Leu Phe Glu 645 650 655 Asp Arg Glu Met Ile Glu Glu Arg Leu
Lys Thr Tyr Ala His Leu Phe 660 665 670 Asp Asp Lys Val Met Lys Gln
Leu Lys Arg Arg Arg Tyr Thr Gly Trp 675 680 685 Gly Arg Leu Ser Arg
Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 690 695 700 Gly Lys Thr
Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 705 710 715 720
Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 725
730 735 Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu
His 740 745 750 Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly
Ile Leu Gln 755 760 765 Thr Val Lys Val Val Asp Glu Leu Val Lys Val
Met Gly Arg His Lys 770 775 780 Pro Glu Asn Ile Val Ile Glu Met Ala
Arg Glu Asn Gln Thr Thr Gln 785 790 795 800 Lys Gly Gln Lys Asn Ser
Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 805 810 815 Ile Lys Glu Leu
Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 820 825 830 Thr Gln
Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 835 840 845
Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 850
855 860 Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp
Ser 865 870 875 880 Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn
Arg Gly Lys Ser 885 890 895 Asp Asn Val Pro Ser Glu Glu Val Val Lys
Lys Met Lys Asn Tyr Trp 900 905 910 Arg Gln Leu Leu Asn Ala Lys Leu
Ile Thr Gln Arg Lys Phe Asp Asn 915 920 925 Leu Thr Lys Ala Glu Arg
Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 930 935 940 Phe Ile Lys Arg
Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 945 950 955 960 Ala
Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 965 970
975 Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val
980 985 990 Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu
Ile Asn 995 1000 1005 Asn Tyr His His Ala His Asp Ala Tyr Leu Asn
Ala Val Val Gly 1010 1015 1020 Thr Ala Leu Ile Lys Lys Tyr Pro Lys
Leu Glu Ser Glu Phe Val 1025 1030 1035 Tyr Gly Asp Tyr Lys Val Tyr
Asp Val Arg Lys Met Ile Ala Lys 1040 1045 1050 Ser Glu Gln Glu Ile
Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr 1055 1060 1065 Ser Asn Ile
Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn 1070 1075 1080 Gly
Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr 1085 1090
1095 Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg
1100 1105 1110 Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys
Thr Glu 1115 1120 1125 Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile
Leu Pro Lys Arg 1130 1135 1140 Asn Ser Asp Lys Leu Ile Ala Arg Lys
Lys Asp Trp Asp Pro Lys 1145 1150 1155 Lys Tyr Gly Gly Phe Asp Ser
Pro Thr Val Ala Tyr Ser Val Leu 1160 1165 1170 Val Val Ala Lys Val
Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 1175 1180 1185 Val Lys Glu
Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe 1190 1195 1200 Glu
Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 1205 1210
1215 Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe
1220 1225 1230 Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala
Gly Glu 1235 1240 1245 Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser
Lys Tyr Val Asn 1250 1255 1260 Phe Leu Tyr Leu Ala Ser His Tyr Glu
Lys Leu Lys Gly Ser Pro 1265 1270 1275 Glu Asp Asn Glu Gln Lys Gln
Leu Phe Val Glu Gln His Lys His 1280 1285 1290 Tyr Leu Asp Glu Ile
Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg 1295 1300 1305 Val Ile Leu
Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr 1310 1315 1320 Asn
Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile 1325 1330
1335 Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe
1340 1345 1350 Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr
Ser Thr 1355 1360 1365 Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln
Ser Ile Thr Gly 1370 1375 1380 Leu Tyr Glu Thr Arg Ile Asp Leu Ser
Gln Leu Gly Gly Asp Gly 1385 1390 1395 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Tyr 1400 1405 1410 Val Val Lys Arg Arg
Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe 1415 1420 1425 Gly Tyr Leu
Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe 1430 1435 1440 Leu
Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr 1445 1450
1455 Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala
1460 1465 1470 Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu
Ser Leu 1475 1480 1485 Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu
Asp Arg Lys Ala 1490 1495 1500 Glu Pro Glu Gly Leu Arg Arg Leu His
Arg Ala Gly Val Gln Ile 1505 1510 1515 Ala Ile Met Thr Phe Lys Asp
Tyr Phe Tyr Cys Trp Asn Thr Phe 1520 1525 1530 Val Glu Asn His Glu
Arg Thr Phe Lys Ala Trp Glu Gly Leu His 1535 1540 1545 Glu Asn Ser
Val Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu 1550 1555 1560 Pro
Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu 1565 1570
1575 Gly Leu 1580 <210> SEQ ID NO 31 <211> LENGTH: 1564
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polypeptide <400> SEQUENCE: 31 Met Asp Ser Leu Leu Met Asn
Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala
Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg
Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 35 40 45 Leu
Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55
60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp
65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val
Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile
Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu
Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile
Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr
Phe Val Glu Asn His Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu
Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg
Arg Ile Leu Leu Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 180 185
190 Gly Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly
195 200 205 Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys
Val Pro 210 215 220 Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg
His Ser Ile Lys 225 230 235 240 Lys Asn Leu Ile Gly Ala Leu Leu Phe
Asp Ser Gly Glu Thr Ala Glu 245 250 255 Ala Thr Arg Leu Lys Arg Thr
Ala Arg Arg Arg Tyr Thr Arg Arg Lys 260 265 270 Asn Arg Ile Cys Tyr
Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 275 280 285 Val Asp Asp
Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 290 295 300 Glu
Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 305 310
315 320 Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg
Lys 325 330 335 Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu
Ile Tyr Leu 340 345 350 Ala Leu Ala His Met Ile Lys Phe Arg Gly His
Phe Leu Ile Glu Gly 355 360 365 Asp Leu Asn Pro Asp Asn Ser Asp Val
Asp Lys Leu Phe Ile Gln Leu 370 375 380 Val Gln Thr Tyr Asn Gln Leu
Phe Glu Glu Asn Pro Ile Asn Ala Ser 385 390 395 400 Gly Val Asp Ala
Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 405 410 415 Arg Leu
Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 420 425 430
Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 435
440 445 Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser
Lys 450 455 460 Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln
Ile Gly Asp 465 470 475 480 Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys
Asn Leu Ser Asp Ala Ile 485 490 495 Leu Leu Ser Asp Ile Leu Arg Val
Asn Thr Glu Ile Thr Lys Ala Pro 500 505 510 Leu Ser Ala Ser Met Ile
Lys Arg Tyr Asp Glu His His Gln Asp Leu 515 520 525 Thr Leu Leu Lys
Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 530 535 540 Glu Ile
Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 545 550 555
560 Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu
565 570 575 Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn
Arg Glu 580 585 590 Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly
Ser Ile Pro His 595 600 605 Gln Ile His Leu Gly Glu Leu His Ala Ile
Leu Arg Arg Gln Glu Asp 610 615 620 Phe Tyr Pro Phe Leu Lys Asp Asn
Arg Glu Lys Ile Glu Lys Ile Leu 625 630 635 640 Thr Phe Arg Ile Pro
Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 645 650 655 Arg Phe Ala
Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 660 665 670 Asn
Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 675 680
685 Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu
690 695 700 Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn
Glu Leu 705 710 715 720 Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg
Lys Pro Ala Phe Leu 725 730 735 Ser Gly Glu Gln Lys Lys Ala Ile Val
Asp Leu Leu Phe Lys Thr Asn 740 745 750 Arg Lys Val Thr Val Lys Gln
Leu Lys Glu Asp Tyr Phe Lys Lys Ile 755 760 765 Glu Cys Phe Asp Ser
Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 770 775 780 Ala Ser Leu
Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 785 790 795 800
Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 805
810 815 Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg
Leu 820 825 830 Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys
Gln Leu Lys 835 840 845 Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser
Arg Lys Leu Ile Asn 850 855 860 Gly Ile Arg Asp Lys Gln Ser Gly Lys
Thr Ile Leu Asp Phe Leu Lys 865 870 875 880 Ser Asp Gly Phe Ala Asn
Arg Asn Phe Met Gln Leu Ile His Asp Asp 885 890 895 Ser Leu Thr Phe
Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 900 905 910 Gly Asp
Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 915 920 925
Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 930
935 940 Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met
Ala 945 950 955 960 Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn
Ser Arg Glu Arg 965 970 975 Met Lys Arg Ile Glu Glu Gly Ile Lys Glu
Leu Gly Ser Gln Ile Leu 980 985 990 Lys Glu His Pro Val Glu Asn Thr
Gln Leu Gln Asn Glu Lys Leu Tyr 995 1000 1005 Leu Tyr Tyr Leu Gln
Asn Gly Arg Asp Met Tyr Val Asp Gln Glu 1010 1015 1020 Leu Asp Ile
Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 1025 1030 1035 Pro
Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 1040 1045
1050 Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser
1055 1060 1065 Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln
Leu Leu 1070 1075 1080 Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp
Asn Leu Thr Lys 1085 1090 1095 Ala Glu Arg Gly Gly Leu Ser Glu Leu
Asp Lys Ala Gly Phe Ile 1100 1105 1110 Lys Arg Gln Leu Val Glu Thr
Arg Gln Ile Thr Lys His Val Ala 1115 1120 1125 Gln Ile Leu Asp Ser
Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 1130 1135 1140 Lys Leu Ile
Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu 1145 1150 1155 Val
Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 1160 1165
1170 Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val
1175 1180 1185 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu
Ser Glu 1190 1195 1200 Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val
Arg Lys Met Ile 1205 1210 1215 Ala Lys Ser Glu Gln Glu Ile Gly Lys
Ala Thr Ala Lys Tyr Phe 1220 1225 1230 Phe Tyr Ser Asn Ile Met Asn
Phe Phe Lys Thr Glu Ile Thr Leu 1235 1240 1245 Ala Asn Gly Glu Ile
Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly 1250 1255 1260 Glu Thr Gly
Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr 1265 1270 1275 Val
Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys 1280 1285
1290 Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro
1295 1300 1305 Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp
Trp Asp 1310 1315 1320 Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr
Val Ala Tyr Ser 1325 1330 1335 Val Leu Val Val Ala Lys Val Glu Lys
Gly Lys Ser Lys Lys Leu 1340 1345 1350 Lys Ser Val Lys Glu Leu Leu
Gly Ile Thr Ile Met Glu Arg Ser 1355 1360 1365 Ser Phe Glu Lys Asn
Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr 1370 1375 1380 Lys Glu Val
Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser 1385 1390 1395 Leu
Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 1400 1405
1410 Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr
1415 1420 1425 Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu
Lys Gly 1430 1435 1440 Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe
Val Glu Gln His 1445 1450 1455 Lys His Tyr Leu Asp Glu Ile Ile Glu
Gln Ile Ser Glu Phe Ser 1460 1465 1470 Lys Arg Val Ile Leu Ala Asp
Ala Asn Leu Asp Lys Val Leu Ser 1475 1480 1485 Ala Tyr Asn Lys His
Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu 1490 1495 1500 Asn Ile Ile
His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala 1505 1510 1515 Ala
Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr 1520 1525
1530 Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile
1535 1540 1545 Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu
Gly Gly 1550 1555 1560 Asp <210> SEQ ID NO 32 <211>
LENGTH: 1579 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 32 Met Asp Ser Leu Leu
Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg
Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Asp Lys 20 25 30 Lys
Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala 35 40
45 Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu
50 55 60 Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly
Ala Leu 65 70 75 80 Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg
Leu Lys Arg Thr 85 90 95 Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn
Arg Ile Cys Tyr Leu Gln 100 105 110 Glu Ile Phe Ser Asn Glu Met Ala
Lys Val Asp Asp Ser Phe Phe His 115 120 125 Arg Leu Glu Glu Ser Phe
Leu Val Glu Glu Asp Lys Lys His Glu Arg 130 135 140 His Pro Ile Phe
Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys 145 150 155 160 Tyr
Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 165 170
175 Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys
180 185 190 Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp
Asn Ser 195 200 205 Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr
Tyr Asn Gln Leu 210 215 220 Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly
Val Asp Ala Lys Ala Ile 225 230 235 240 Leu Ser Ala Arg Leu Ser Lys
Ser Arg Arg Leu Glu Asn Leu Ile Ala 245 250 255 Gln Leu Pro Gly Glu
Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala 260 265 270 Leu Ser Leu
Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala 275 280 285 Glu
Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 290 295
300 Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu
305 310 315 320 Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp
Ile Leu Arg 325 330 335 Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser
Ala Ser Met Ile Lys 340 345 350 Arg Tyr Asp Glu His His Gln Asp Leu
Thr Leu Leu Lys Ala Leu Val 355 360 365 Arg Gln Gln Leu Pro Glu Lys
Tyr Lys Glu Ile Phe Phe Asp Gln Ser 370 375 380 Lys Asn Gly Tyr Ala
Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu 385 390 395 400 Phe Tyr
Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu 405 410 415
Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 420
425 430 Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu
Leu 435 440 445 His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe
Leu Lys Asp 450 455 460 Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe
Arg Ile Pro Tyr Tyr 465 470 475 480 Val Gly Pro Leu Ala Arg Gly Asn
Ser Arg Phe Ala Trp Met Thr Arg 485 490 495 Lys Ser Glu Glu Thr Ile
Thr Pro Trp Asn Phe Glu Glu Val Val Asp 500 505 510 Lys Gly Ala Ser
Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp 515 520 525 Lys Asn
Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr 530 535 540
Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 545
550 555 560 Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys
Lys Ala 565 570 575 Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val
Thr Val Lys Gln 580 585 590 Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu
Cys Phe Asp Ser Val Glu 595 600 605 Ile Ser Gly Val Glu Asp Arg Phe
Asn Ala Ser Leu Gly Thr Tyr His 610 615 620 Asp Leu Leu Lys Ile Ile
Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu 625 630 635 640 Asn Glu Asp
Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu 645 650 655 Asp
Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 660 665
670 Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp
675 680 685 Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys
Gln Ser 690 695 700 Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly
Phe Ala Asn Arg 705 710 715 720 Asn Phe Met Gln Leu Ile His Asp Asp
Ser Leu Thr Phe Lys Glu Asp 725 730 735 Ile Gln Lys Ala Gln Val Ser
Gly Gln Gly Asp Ser Leu His Glu His 740 745 750 Ile Ala Asn Leu Ala
Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 755 760 765 Thr Val Lys
Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys 770 775 780 Pro
Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 785 790
795 800 Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu
Gly 805 810 815 Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro
Val Glu Asn 820 825 830 Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr
Tyr Leu Gln Asn Gly 835 840 845 Arg Asp Met Tyr Val Asp Gln Glu Leu
Asp Ile Asn Arg Leu Ser Asp 850 855 860 Tyr Asp Val Asp Ala Ile Val
Pro Gln Ser Phe Leu Lys Asp Asp Ser 865 870 875 880 Ile Asp Asn Lys
Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser 885 890 895 Asp Asn
Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp 900 905 910
Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 915
920 925 Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala
Gly 930 935 940 Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr
Lys His Val 945 950 955 960 Ala Gln Ile Leu Asp Ser Arg Met Asn Thr
Lys Tyr Asp Glu Asn Asp 965 970 975 Lys Leu Ile Arg Glu Val Lys Val
Ile Thr Leu Lys Ser Lys Leu Val 980 985 990 Ser Asp Phe Arg Lys Asp
Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn 995 1000 1005 Asn Tyr His
His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly 1010 1015 1020 Thr
Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val 1025 1030
1035 Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys
1040 1045 1050 Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe
Phe Tyr 1055 1060 1065 Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile
Thr Leu Ala Asn 1070 1075 1080 Gly Glu Ile Arg Lys Arg Pro Leu Ile
Glu Thr Asn Gly Glu Thr 1085 1090 1095 Gly Glu Ile Val Trp Asp Lys
Gly Arg Asp Phe Ala Thr Val Arg 1100 1105 1110 Lys Val Leu Ser Met
Pro Gln Val Asn Ile Val Lys Lys Thr Glu 1115 1120 1125 Val Gln Thr
Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg 1130 1135 1140 Asn
Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys 1145 1150
1155 Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu
1160 1165 1170 Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu
Lys Ser 1175 1180 1185 Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu
Arg Ser Ser Phe 1190 1195 1200 Glu Lys Asn Pro Ile Asp Phe Leu Glu
Ala Lys Gly Tyr Lys Glu 1205 1210 1215 Val Lys Lys Asp Leu Ile Ile
Lys Leu Pro Lys Tyr Ser Leu Phe 1220 1225 1230 Glu Leu Glu Asn Gly
Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 1235 1240 1245 Leu Gln Lys
Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn 1250 1255 1260 Phe
Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 1265 1270
1275 Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His
1280 1285 1290 Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser
Lys Arg 1295 1300 1305 Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val
Leu Ser Ala Tyr 1310 1315 1320 Asn Lys His Arg Asp Lys Pro Ile Arg
Glu Gln Ala Glu Asn Ile 1325 1330 1335 Ile His Leu Phe Thr Leu Thr
Asn Leu Gly Ala Pro Ala Ala Phe 1340 1345 1350 Lys Tyr Phe Asp Thr
Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr 1355 1360 1365 Lys Glu Val
Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly 1370 1375 1380 Leu
Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly 1385 1390
1395 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr
1400 1405 1410 Val Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu
Asp Phe 1415 1420 1425 Gly His Leu Arg Asn Lys Ser Gly Cys His Val
Glu Leu Leu Phe 1430 1435 1440 Leu Arg Tyr Ile Ser Asp Trp Asp Leu
Asp Pro Gly Arg Cys Tyr 1445 1450 1455 Arg Val Thr Trp Phe Thr Ser
Trp Ser Pro Cys Tyr Asp Cys Ala 1460 1465 1470 Arg His Val Ala Glu
Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu 1475 1480 1485 Arg Ile Phe
Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala 1490 1495 1500 Glu
Pro Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile 1505 1510
1515 Gly Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe
1520 1525 1530 Val Glu Asn Arg Glu Arg Thr Phe Lys Ala Trp Glu Gly
Leu His 1535 1540 1545 Glu Asn Ser Val Arg Leu Thr Arg Gln Leu Arg
Arg Ile Leu Leu 1550 1555 1560 Pro Leu Tyr Glu Val Asp Asp Leu Arg
Asp Ala Phe Arg Met Leu 1565 1570 1575 Gly <210> SEQ ID NO 33
<211> LENGTH: 1724 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 33
Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Leu Lys Tyr 1 5
10 15 His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys
Leu 20 25 30 His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser
Trp Ser Pro 35 40 45 Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe
Leu Ala Glu Asp Pro 50 55 60 Lys Val Thr Leu Thr Ile Phe Val Ala
Arg Leu Tyr Tyr Phe Trp Asp 65 70 75 80 Pro Asp Tyr Gln Glu Ala Leu
Arg Ser Leu Cys Gln Lys Arg Asp Gly 85 90 95 Pro Arg Ala Thr Met
Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 100 105 110 Trp Ser Lys
Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 115 120 125 Asn
Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 130 135
140 Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn
145 150 155 160 Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys
Tyr Glu Val 165 170 175 Glu Arg Met His Asn Asp Thr Trp Val Leu Leu
Asn Gln Arg Arg Gly 180 185 190 Phe Leu Cys Asn Gln Ala Pro His Lys
His Gly Phe Leu Glu Gly Arg 195 200 205 His Ala Glu Leu Cys Phe Leu
Asp Val Ile Pro Phe Trp Lys Leu Asp 210 215 220 Leu Asp Gln Asp Tyr
Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 225 230 235 240 Phe Ser
Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 245 250 255
Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 260
265 270 Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile
Ser 275 280 285 Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr
Phe Val Asp 290 295 300 His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly
Leu Asp Glu His Ser 305 310 315 320 Gln Asp Leu Ser Gly Arg Leu Arg
Ala Ile Leu Gln Asn Gln Glu Asn 325 330 335 Ser Pro Lys Lys Lys Arg
Lys Val Glu Ala Ser Ser Pro Lys Lys Lys 340 345 350 Arg Lys Val Glu
Ala Ser Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 355 360 365 Thr Asn
Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 370 375 380
Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 385
390 395 400 Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr
Ala Glu 405 410 415 Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr
Thr Arg Arg Lys 420 425 430 Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe
Ser Asn Glu Met Ala Lys 435 440 445 Val Asp Asp Ser Phe Phe His Arg
Leu Glu Glu Ser Phe Leu Val Glu 450 455 460 Glu Asp Lys Lys His Glu
Arg His Pro Ile Phe Gly Asn Ile Val Asp 465 470 475 480 Glu Val Ala
Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 485 490 495 Lys
Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 500 505
510 Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly
515 520 525 Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile
Gln Leu 530 535 540 Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro
Ile Asn Ala Ser 545 550 555 560 Gly Val Asp Ala Lys Ala Ile Leu Ser
Ala Arg Leu Ser Lys Ser Arg 565 570 575 Arg Leu Glu Asn Leu Ile Ala
Gln Leu Pro Gly Glu Lys Lys Asn Gly 580 585 590 Leu Phe Gly Asn Leu
Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 595 600 605 Lys Ser Asn
Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 610 615 620 Asp
Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 625 630
635 640 Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala
Ile 645 650 655 Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr
Lys Ala Pro 660 665 670 Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu
His His Gln Asp Leu 675 680 685 Thr Leu Leu Lys Ala Leu Val Arg Gln
Gln Leu Pro Glu Lys Tyr Lys 690 695 700 Glu Ile Phe Phe Asp Gln Ser
Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 705 710 715 720 Gly Gly Ala Ser
Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 725 730 735 Glu Lys
Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 740 745 750
Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 755
760 765 Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu
Asp 770 775 780 Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu
Lys Ile Leu 785 790 795 800 Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro
Leu Ala Arg Gly Asn Ser 805 810 815 Arg Phe Ala Trp Met Thr Arg Lys
Ser Glu Glu Thr Ile Thr Pro Trp 820 825 830 Asn Phe Glu Glu Val Val
Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 835 840 845 Glu Arg Met Thr
Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 850 855 860 Pro Lys
His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 865 870 875
880 Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu
885 890 895 Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys
Thr Asn 900 905 910 Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr
Phe Lys Lys Ile 915 920 925 Glu Cys Phe Asp Ser Val Glu Ile Ser Gly
Val Glu Asp Arg Phe Asn 930 935 940 Ala Ser Leu Gly Thr Tyr His Asp
Leu Leu Lys Ile Ile Lys Asp Lys 945 950 955 960 Asp Phe Leu Asp Asn
Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 965 970 975 Leu Thr Leu
Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 980 985 990 Lys
Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 995
1000 1005 Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu
Ile 1010 1015 1020 Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile
Leu Asp Phe 1025 1030 1035 Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn
Phe Met Gln Leu Ile 1040 1045 1050 His Asp Asp Ser Leu Thr Phe Lys
Glu Asp Ile Gln Lys Ala Gln 1055 1060 1065 Val Ser Gly Gln Gly Asp
Ser Leu His Glu His Ile Ala Asn Leu 1070 1075 1080 Ala Gly Ser Pro
Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 1085 1090 1095 Val Val
Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 1100 1105 1110
Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 1115
1120 1125 Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu
Gly 1130 1135 1140 Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His
Pro Val Glu 1145 1150 1155 Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr
Leu Tyr Tyr Leu Gln 1160 1165 1170 Asn Gly Arg Asp Met Tyr Val Asp
Gln Glu Leu Asp Ile Asn Arg 1175 1180 1185 Leu Ser Asp Tyr Asp Val
Asp Ala Ile Val Pro Gln Ser Phe Leu 1190 1195 1200 Lys Asp Asp Ser
Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 1205 1210 1215 Asn Arg
Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 1220 1225 1230
Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile 1235
1240 1245 Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly
Gly 1250 1255 1260 Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg
Gln Leu Val 1265 1270 1275 Glu Thr Arg Gln Ile Thr Lys His Val Ala
Gln Ile Leu Asp Ser 1280 1285 1290 Arg Met Asn Thr Lys Tyr Asp Glu
Asn Asp Lys Leu Ile Arg Glu 1295 1300 1305 Val Lys Val Ile Thr Leu
Lys Ser Lys Leu Val Ser Asp Phe Arg 1310 1315 1320 Lys Asp Phe Gln
Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His 1325 1330 1335 His Ala
His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu 1340 1345 1350
Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp 1355
1360 1365 Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu
Gln 1370 1375 1380 Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr
Ser Asn Ile 1385 1390 1395 Met Asn Phe Phe Lys Thr Glu Ile Thr Leu
Ala Asn Gly Glu Ile 1400 1405 1410 Arg Lys Arg Pro Leu Ile Glu Thr
Asn Gly Glu Thr Gly Glu Ile 1415 1420 1425 Val Trp Asp Lys Gly Arg
Asp Phe Ala Thr Val Arg Lys Val Leu 1430 1435 1440 Ser Met Pro Gln
Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr 1445 1450 1455 Gly Gly
Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp 1460 1465 1470
Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 1475
1480 1485 Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val
Ala 1490 1495 1500 Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser
Val Lys Glu 1505 1510 1515 Leu Leu Gly Ile Thr Ile Met Glu Arg Ser
Ser Phe Glu Lys Asn 1520 1525 1530 Pro Ile Asp Phe Leu Glu Ala Lys
Gly Tyr Lys Glu Val Lys Lys 1535 1540 1545 Asp Leu Ile Ile Lys Leu
Pro Lys Tyr Ser Leu Phe Glu Leu Glu 1550 1555 1560 Asn Gly Arg Lys
Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys 1565 1570 1575 Gly Asn
Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 1580 1585 1590
Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn 1595
1600 1605 Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu
Asp 1610 1615 1620 Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg
Val Ile Leu 1625 1630 1635 Ala Asp Ala Asn Leu Asp Lys Val Leu Ser
Ala Tyr Asn Lys His 1640 1645 1650 Arg Asp Lys Pro Ile Arg Glu Gln
Ala Glu Asn Ile Ile His Leu 1655 1660 1665 Phe Thr Leu Thr Asn Leu
Gly Ala Pro Ala Ala Phe Lys Tyr Phe 1670 1675 1680 Asp Thr Thr Ile
Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val 1685 1690 1695 Leu Asp
Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu 1700 1705 1710
Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1715 1720 <210>
SEQ ID NO 34 <211> LENGTH: 1368 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 34 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr
Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val
Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His
Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser
Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg
Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln
Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe
Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105
110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr
115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu
Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu
Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu
Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys
Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu
Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile
Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu
Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230
235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn
Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp
Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly
Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser
Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu
Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg
Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu
Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350
Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355
360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met
Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp
Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile
Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg
Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu
Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val
Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr
Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475
480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr
485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys
His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu
Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala
Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu
Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys
Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu
Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr
Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600
605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr
610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr
Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu
Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys
Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile
Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe
Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp
Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720
His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725
730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met
Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg
Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu
Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser
Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu
Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg
Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser
Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 835 840 845
Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850
855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met
Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile
Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly
Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln
Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile
Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys
Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys
Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970
975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val
980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser
Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg
Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala
Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe
Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg
Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu
Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg
Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090
1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys
1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp
Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val
Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly
Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly
Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro
Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys
Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe
Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210
1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val
1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys
Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val
Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln
Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala
Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg
Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His
Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe
Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330
1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr
1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly
Gly Asp 1355 1360 1365 <210> SEQ ID NO 35 <211> LENGTH:
1851 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 35 Met Asp Ser Leu Leu
Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg
Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Ser Met 20 25 30 Gly
Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly 35 40
45 Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe
50 55 60 Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu
Lys Glu 65 70 75 80 Asp Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val
Trp Lys Leu Arg 85 90 95 Arg Asp Leu Ile Phe Val Phe Phe Ser Ser
His Thr Pro Cys Gly Asp 100 105 110 Ala Ser Ile Ile Pro Met Leu Glu
Phe Glu Asp Gln Pro Cys Cys Pro 115 120 125 Val Phe Arg Asn Trp Ala
His Asn Ser Ser Val Glu Ala Ser Ser Asn 130 135 140 Leu Glu Ala Pro
Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro 145 150 155 160 Val
Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val 165 170
175 Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys Ser Gly
180 185 190 Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu
Gly Leu 195 200 205 Ala Thr Val Thr Arg Ile Ala Pro Gly Ser Ala Lys
Val Ile Asp Val 210 215 220 Tyr Arg Thr Gly Ala Lys Cys Val Pro Gly
Glu Ala Gly Asp Ser Gly 225 230 235 240 Lys Pro Gly Ala Ala Phe His
Gln Val Gly Leu Leu Arg Val Lys Pro 245 250 255 Gly Arg Gly Asp Arg
Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 260 265 270 Arg Trp Asn
Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu 275 280 285 Glu
Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr 290 295
300 Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val
305 310 315 320 Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys
Ile Leu Gln 325 330 335 Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala
Val Gln Ala Lys Arg 340 345 350 Ala Asp Ser Pro Gly Arg Leu Val Pro
Cys Gly Ala Ala Ile Ser Trp 355 360 365 Ser Ala Val Pro Glu Gln Pro
Leu Asp Val Thr Ala Asn Gly Phe Pro 370 375 380 Gln Gly Thr Thr Lys
Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln 385 390 395 400 Ile Ser
Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg 405 410 415
Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu Asp 420
425 430 Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala
Trp 435 440 445 Ser Thr Leu Arg Lys Gln Val Phe Gly Ser Trp Ile Arg
Asn Pro Pro 450 455 460 Asp Tyr His Gln Phe Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 465 470 475 480 Gly Gly Gly Ser Asp Lys Lys Tyr
Ser Ile Gly Leu Ala Ile Gly Thr 485 490 495 Asn Ser Val Gly Trp Ala
Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 500 505 510 Lys Lys Phe Lys
Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 515 520 525 Asn Leu
Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 530 535 540
Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 545
550 555 560 Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala
Lys Val 565 570 575 Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe
Leu Val Glu Glu 580 585 590 Asp Lys Lys His Glu Arg His Pro Ile Phe
Gly Asn Ile Val Asp Glu 595 600 605 Val Ala Tyr His Glu Lys Tyr Pro
Thr Ile Tyr His Leu Arg Lys Lys 610 615 620 Leu Val Asp Ser Thr Asp
Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 625 630 635 640 Leu Ala His
Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 645 650 655 Leu
Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 660 665
670 Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly
675 680 685 Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser
Arg Arg 690 695 700 Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys
Lys Asn Gly Leu 705 710 715 720 Phe Gly Asn Leu Ile Ala Leu Ser Leu
Gly Leu Thr Pro Asn Phe Lys 725 730 735 Ser Asn Phe Asp Leu Ala Glu
Asp Ala Lys Leu Gln Leu Ser Lys Asp 740 745 750 Thr Tyr Asp Asp Asp
Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 755 760 765 Tyr Ala Asp
Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 770 775 780 Leu
Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 785 790
795 800 Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu
Thr 805 810 815 Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys
Tyr Lys Glu 820 825 830 Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala
Gly Tyr Ile Asp Gly 835 840 845 Gly Ala Ser Gln Glu Glu Phe Tyr Lys
Phe Ile Lys Pro Ile Leu Glu 850 855 860 Lys Met Asp Gly Thr Glu Glu
Leu Leu Val Lys Leu Asn Arg Glu Asp 865 870 875 880 Leu Leu Arg Lys
Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 885 890 895 Ile His
Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 900 905 910
Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 915
920 925 Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser
Arg 930 935 940 Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr
Pro Trp Asn 945 950 955 960 Phe Glu Glu Val Val Asp Lys Gly Ala Ser
Ala Gln Ser Phe Ile Glu 965 970 975 Arg Met Thr Asn Phe Asp Lys Asn
Leu Pro Asn Glu Lys Val Leu Pro 980 985 990 Lys His Ser Leu Leu Tyr
Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 995 1000 1005 Lys Val Lys
Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 1010 1015 1020 Ser
Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr 1025 1030
1035 Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys
1040 1045 1050 Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val
Glu Asp 1055 1060 1065 Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp
Leu Leu Lys Ile 1070 1075 1080 Ile Lys Asp Lys Asp Phe Leu Asp Asn
Glu Glu Asn Glu Asp Ile 1085 1090 1095 Leu Glu Asp Ile Val Leu Thr
Leu Thr Leu Phe Glu Asp Arg Glu 1100 1105 1110 Met Ile Glu Glu Arg
Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 1115 1120 1125 Lys Val Met
Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 1130 1135 1140 Arg
Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 1145 1150
1155 Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn
1160 1165 1170 Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr
Phe Lys 1175 1180 1185 Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln
Gly Asp Ser Leu 1190 1195 1200 His Glu His Ile Ala Asn Leu Ala Gly
Ser Pro Ala Ile Lys Lys 1205 1210 1215 Gly Ile Leu Gln Thr Val Lys
Val Val Asp Glu Leu Val Lys Val 1220 1225 1230 Met Gly Arg His Lys
Pro Glu Asn Ile Val Ile Glu Met Ala Arg 1235 1240 1245 Glu Asn Gln
Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 1250 1255 1260 Met
Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile 1265 1270
1275 Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys
1280 1285 1290 Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr
Val Asp 1295 1300 1305 Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr
Asp Val Asp Ala 1310 1315 1320 Ile Val Pro Gln Ser Phe Leu Lys Asp
Asp Ser Ile Asp Asn Lys 1325 1330 1335 Val Leu Thr Arg Ser Asp Lys
Asn Arg Gly Lys Ser Asp Asn Val 1340 1345 1350 Pro Ser Glu Glu Val
Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 1355 1360 1365 Leu Leu Asn
Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu 1370 1375 1380 Thr
Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 1385 1390
1395 Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His
1400 1405 1410 Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr
Asp Glu 1415 1420 1425 Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile
Thr Leu Lys Ser 1430 1435 1440 Lys Leu Val Ser Asp Phe Arg Lys Asp
Phe Gln Phe Tyr Lys Val 1445 1450 1455 Arg Glu Ile Asn Asn Tyr His
His Ala His Asp Ala Tyr Leu Asn 1460 1465 1470 Ala Val Val Gly Thr
Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu 1475 1480 1485 Ser Glu Phe
Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys 1490 1495 1500 Met
Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys 1505 1510
1515 Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile
1520 1525 1530 Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile
Glu Thr 1535 1540 1545 Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys
Gly Arg Asp Phe 1550 1555 1560 Ala Thr Val Arg Lys Val Leu Ser Met
Pro Gln Val Asn Ile Val 1565 1570 1575 Lys Lys Thr Glu Val Gln Thr
Gly Gly Phe Ser Lys Glu Ser Ile 1580 1585 1590 Leu Pro Lys Arg Asn
Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 1595 1600 1605 Trp Asp Pro
Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala 1610 1615 1620 Tyr
Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys 1625 1630
1635 Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu
1640 1645 1650 Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu
Ala Lys 1655 1660 1665 Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile
Lys Leu Pro Lys 1670 1675 1680 Tyr Ser Leu Phe Glu Leu Glu Asn Gly
Arg Lys Arg Met Leu Ala 1685 1690 1695 Ser Ala Gly Glu Leu Gln Lys
Gly Asn Glu Leu Ala Leu Pro Ser 1700 1705 1710 Lys Tyr Val Asn Phe
Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu 1715 1720 1725 Lys Gly Ser
Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 1730 1735 1740 Gln
His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu 1745 1750
1755 Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val
1760 1765 1770 Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg
Glu Gln 1775 1780 1785 Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr
Asn Leu Gly Ala 1790 1795 1800 Pro Ala Ala Phe Lys Tyr Phe Asp Thr
Thr Ile Asp Arg Lys Arg 1805 1810 1815 Tyr Thr Ser Thr Lys Glu Val
Leu Asp Ala Thr Leu Ile His Gln 1820 1825 1830 Ser Ile Thr Gly Leu
Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu 1835 1840 1845 Gly Gly Asp
1850 <210> SEQ ID NO 36 <211> LENGTH: 1846 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 36 Met Asp Ser Leu Leu Met Asn Arg Arg Lys
Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg
Arg Glu Thr Tyr Leu Cys Asp Lys 20 25 30 Lys Tyr Ser Ile Gly Leu
Ala Ile Gly Thr Asn Ser Val Gly Trp Ala 35 40 45 Val Ile Thr Asp
Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu 50 55 60 Gly Asn
Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 65 70 75 80
Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 85
90 95 Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu
Gln 100 105 110 Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser
Phe Phe His 115 120 125 Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp
Lys Lys His Glu Arg 130 135 140 His Pro Ile Phe Gly Asn Ile Val Asp
Glu Val Ala Tyr His Glu Lys 145 150 155 160 Tyr Pro Thr Ile Tyr His
Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 165 170 175 Lys Ala Asp Leu
Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys 180 185 190 Phe Arg
Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 195 200 205
Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 210
215 220 Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala
Ile 225 230 235 240 Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu
Asn Leu Ile Ala 245 250 255 Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu
Phe Gly Asn Leu Ile Ala 260 265 270 Leu Ser Leu Gly Leu Thr Pro Asn
Phe Lys Ser Asn Phe Asp Leu Ala 275 280 285 Glu Asp Ala Lys Leu Gln
Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 290 295 300 Asp Asn Leu Leu
Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 305 310 315 320 Ala
Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 325 330
335 Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys
340 345 350 Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala
Leu Val 355 360 365 Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe
Phe Asp Gln Ser 370 375 380 Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly
Gly Ala Ser Gln Glu Glu 385 390 395 400 Phe Tyr Lys Phe Ile Lys Pro
Ile Leu Glu Lys Met Asp Gly Thr Glu 405 410 415 Glu Leu Leu Val Lys
Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 420 425 430 Thr Phe Asp
Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu 435 440 445 His
Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 450 455
460 Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr
465 470 475 480 Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp
Met Thr Arg 485 490 495 Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe
Glu Glu Val Val Asp 500 505 510 Lys Gly Ala Ser Ala Gln Ser Phe Ile
Glu Arg Met Thr Asn Phe Asp 515 520 525 Lys Asn Leu Pro Asn Glu Lys
Val Leu Pro Lys His Ser Leu Leu Tyr 530 535 540 Glu Tyr Phe Thr Val
Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 545 550 555 560 Glu Gly
Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 565 570 575
Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 580
585 590 Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val
Glu 595 600 605 Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly
Thr Tyr His 610 615 620 Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe
Leu Asp Asn Glu Glu 625 630 635 640 Asn Glu Asp Ile Leu Glu Asp Ile
Val Leu Thr Leu Thr Leu Phe Glu 645 650 655 Asp Arg Glu Met Ile Glu
Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 660 665 670 Asp Asp Lys Val
Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp 675 680 685 Gly Arg
Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 690 695 700
Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 705
710 715 720 Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys
Glu Asp 725 730 735 Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser
Leu His Glu His 740 745 750 Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile
Lys Lys Gly Ile Leu Gln 755 760 765 Thr Val Lys Val Val Asp Glu Leu
Val Lys Val Met Gly Arg His Lys 770 775 780 Pro Glu Asn Ile Val Ile
Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 785 790 795 800 Lys Gly Gln
Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 805 810 815 Ile
Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 820 825
830 Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly
835 840 845 Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu
Ser Asp 850 855 860 Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu
Lys Asp Asp Ser 865 870 875 880 Ile Asp Asn Lys Val Leu Thr Arg Ser
Asp Lys Asn Arg Gly Lys Ser 885 890 895 Asp Asn Val Pro Ser Glu Glu
Val Val Lys Lys Met Lys Asn Tyr Trp 900 905 910 Arg Gln Leu Leu Asn
Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 915 920 925 Leu Thr Lys
Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 930 935 940 Phe
Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 945 950
955 960 Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn
Asp 965 970 975 Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser
Lys Leu Val 980 985 990 Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys
Val Arg Glu Ile Asn 995 1000 1005 Asn Tyr His His Ala His Asp Ala
Tyr Leu Asn Ala Val Val Gly 1010 1015 1020 Thr Ala Leu Ile Lys Lys
Tyr Pro Lys Leu Glu Ser Glu Phe Val 1025 1030 1035 Tyr Gly Asp Tyr
Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1040 1045 1050 Ser Glu
Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr 1055 1060 1065
Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn 1070
1075 1080 Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu
Thr 1085 1090 1095 Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala
Thr Val Arg 1100 1105 1110 Lys Val Leu Ser Met Pro Gln Val Asn Ile
Val Lys Lys Thr Glu 1115 1120 1125 Val Gln Thr Gly Gly Phe Ser Lys
Glu Ser Ile Leu Pro Lys Arg 1130 1135 1140 Asn Ser Asp Lys Leu Ile
Ala Arg Lys Lys Asp Trp Asp Pro Lys 1145 1150 1155 Lys Tyr Gly Gly
Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu 1160 1165 1170 Val Val
Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 1175 1180 1185
Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe 1190
1195 1200 Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys
Glu 1205 1210 1215 Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr
Ser Leu Phe 1220 1225 1230 Glu Leu Glu Asn Gly Arg Lys Arg Met Leu
Ala Ser Ala Gly Glu 1235 1240 1245 Leu Gln Lys Gly Asn Glu Leu Ala
Leu Pro Ser Lys Tyr Val Asn 1250 1255 1260 Phe Leu Tyr Leu Ala Ser
His Tyr Glu Lys Leu Lys Gly Ser Pro 1265 1270 1275 Glu Asp Asn Glu
Gln Lys Gln Leu Phe Val Glu Gln His Lys His 1280 1285 1290 Tyr Leu
Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg 1295 1300 1305
Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr 1310
1315 1320 Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn
Ile 1325 1330 1335 Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro
Ala Ala Phe 1340 1345 1350 Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys
Arg Tyr Thr Ser Thr 1355 1360 1365 Lys Glu Val Leu Asp Ala Thr Leu
Ile His Gln Ser Ile Thr Gly 1370 1375 1380 Leu Tyr Glu Thr Arg Ile
Asp Leu Ser Gln Leu Gly Gly Asp Gly 1385 1390 1395 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ser Met Gly Thr Gly Thr 1400 1405 1410 Lys Cys
Ile Gly Gln Ser Lys Met Arg Lys Asn Gly Asp Ile Leu 1415 1420 1425
Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe Gln Arg 1430
1435 1440 Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu Lys Glu
Asp 1445 1450 1455 Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val Trp
Lys Leu Arg 1460 1465 1470 Arg Asp Leu Ile Phe Val Phe Phe Ser Ser
His Thr Pro Cys Gly 1475 1480 1485 Asp Ala Ser Ile Ile Pro Met Leu
Glu Phe Glu Asp Gln Pro Cys 1490 1495 1500 Cys Pro Val Phe Arg Asn
Trp Ala His Asn Ser Ser Val Glu Ala 1505 1510 1515 Ser Ser Asn Leu
Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp 1520 1525 1530 Pro Asp
Ser Pro Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr 1535 1540 1545
Ala Ala Arg Glu Val Thr Asn Gly Ala Ala His His Gln Ser Phe 1550
1555 1560 Gly Lys Gln Lys Ser Gly Pro Ile Ser Pro Gly Ile His Ser
Cys 1565 1570 1575 Asp Leu Thr Val Glu Gly Leu Ala Thr Val Thr Arg
Ile Ala Pro 1580 1585 1590 Gly Ser Ala Lys Val Ile Asp Val Tyr Arg
Thr Gly Ala Lys Cys 1595 1600 1605 Val Pro Gly Glu Ala Gly Asp Ser
Gly Lys Pro Gly Ala Ala Phe 1610 1615 1620 His Gln Val Gly Leu Leu
Arg Val Lys Pro Gly Arg Gly Asp Arg 1625 1630 1635 Thr Arg Ser Met
Ser Cys Ser Asp Lys Met Ala Arg Trp Asn Val 1640 1645 1650 Leu Gly
Cys Gln Gly Ala Leu Leu Met His Leu Leu Glu Glu Pro 1655 1660 1665
Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr Ser Gln 1670
1675 1680 Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val
Ser 1685 1690 1695 Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys
Ile Leu Gln 1700 1705 1710 Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser
Ala Val Gln Ala Lys 1715 1720 1725 Arg Ala Asp Ser Pro Gly Arg Leu
Val Pro Cys Gly Ala Ala Ile 1730 1735 1740 Ser Trp Ser Ala Val Pro
Glu Gln Pro Leu Asp Val Thr Ala Asn 1745 1750 1755 Gly Phe Pro Gln
Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln 1760 1765 1770 Ala Arg
Ser Gln Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln 1775 1780 1785
Lys Leu Leu Ser Arg Ile Ala Arg Asp Lys Trp Pro His Ser Leu 1790
1795 1800 Arg Val Gln Lys Leu Asp Thr Tyr Gln Glu Tyr Lys Glu Ala
Ala 1805 1810 1815 Ser Ser Tyr Gln Glu Ala Trp Ser Thr Leu Arg Lys
Gln Val Phe 1820 1825 1830 Gly Ser Trp Ile Arg Asn Pro Pro Asp Tyr
His Gln Phe 1835 1840 1845 <210> SEQ ID NO 37 <211>
LENGTH: 1368 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 37 Met Asp Lys Lys Tyr
Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala
Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys
Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40
45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu
50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg
Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys
Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu
Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly
Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr
Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys
Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met
Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170
175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr
180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val
Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg
Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys
Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly
Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp
Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu
Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu
Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295
300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser
305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr
Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr
Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly
Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe
Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu
Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln
Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415
Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420
425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg
Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg
Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro
Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala
Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu
Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu
Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val
Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540
Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545
550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys
Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn
Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys
Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu
Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu
Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe
Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr
Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665
670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe
675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu
Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln
Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly
Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val
Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu
Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln
Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu
Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790
795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr
Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp
Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro
Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu
Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro
Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg
Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp
Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910
Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915
920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr
Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr
Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe
Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala
His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile
Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly
Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys
Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030
1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala
1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn
Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp
Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val
Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe
Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys
Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr
Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu
Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150
1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser
1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly
Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro
Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg
Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu
Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu
Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp
Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His
Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270
1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala
1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala
Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly
Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp
Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala
Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr
Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210>
SEQ ID NO 38 <211> LENGTH: 82 <212> TYPE: RNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 38 guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu ccguuaucaa
cuugaaaaag 60 uggcaccgag ucggugcuuu uu 82 <210> SEQ ID NO 39
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 39
gatgacattg catacattcg aaagacccta gccttagata aaactgagca agaggctttg
60 gagtatttca tgaaacaaat gaatgatgca cgtcatggtg gctggacaac
aaaaatggat 120 tggatcttcc acacaattaa acagcatgca ttgaactgaa
agataactga gaaaatgaaa 180 <210> SEQ ID NO 40 <211>
LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 40 Asp Asp Ile Ala Tyr
Ile Arg Lys Thr Leu Ala Leu Asp Lys Thr Glu 1 5 10 15 Gln Glu Ala
Leu Glu Tyr Phe Met Lys Gln Met Asn Asp Ala Arg His 20 25 30 Gly
Gly Trp Thr Thr Lys Met Asp Trp Ile Phe His Thr Ile Lys Gln 35 40
45 His Ala Leu Asn Lys Ile Thr Glu Lys Met Lys 50 55 <210>
SEQ ID NO 41 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 41 aucggaauct auuuugacuc 20 <210> SEQ ID NO 42
<211> LENGTH: 20 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 42
ucggaaucua uuuugacucg 20 <210> SEQ ID NO 43 <211>
LENGTH: 20 <212> TYPE: RNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 43 cuuagauaaa
acugagcaag 20 <210> SEQ ID NO 44 <211> LENGTH: 20
<212> TYPE: RNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 44 aucuauuuug acucguucuc 20
<210> SEQ ID NO 45 <211> LENGTH: 20 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 45 uaaaacugag caagaggcuu 20 <210> SEQ ID NO 46
<211> LENGTH: 20 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 46
ugguggcugg acaacaaaaa 20 <210> SEQ ID NO 47 <211>
LENGTH: 20 <212> TYPE: RNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 47 gcuggacaac
aaaaauggau 20 <210> SEQ ID NO 48 <211> LENGTH: 20
<212> TYPE: RNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 48 guguuaauuu gucguacgua 20
<210> SEQ ID NO 49 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 49 aatcacattt ttccacttct tgaaaagtac tgtggcttcc atgaagataa
cattccccag 60 ctggaagacg tttctcaatt cctgcagact tgcactggtc
tccgcctccg acctgtggct 120 ggcctgcttt cctctcggga tttcttgggt
ggcctggcct tccgagtctt ccactgcaca 180 <210> SEQ ID NO 50
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 50 Asn His
Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp 1 5 10 15
Asn Ile Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr 20
25 30 Gly Ser Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp
Phe 35 40 45 Leu Gly Gly Leu Ala Phe Arg Val Phe His Cys Thr 50 55
60 <210> SEQ ID NO 51 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 51 atgcctgcct ggggagccct gttcctgctc
tgggccacag cagaggccac caaggactgc 60 cccagcccac gtacctgccg
cgccctggaa accatggggc tgtgggtgga ctgcaggggc 120 cacggactca
cggccctgcc tgccctgccg gcccgcaccc gccaccttct gctggccaac 180
<210> SEQ ID NO 52 <211> LENGTH: 60 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 52 Met Pro Ala Trp Gly Ala Leu Phe Leu Leu Trp Ala Thr
Ala Glu Ala 1 5 10 15 Thr Lys Asp Cys Pro Ser Pro Arg Thr Cys Arg
Ala Leu Glu Thr Met 20 25 30 Gly Leu Trp Val Asp Cys Arg Gly His
Gly Leu Thr Ala Leu Pro Ala 35 40 45 Leu Pro Ala Arg Thr Arg His
Leu Leu Leu Ala Asn 50 55 60 <210> SEQ ID NO 53 <211>
LENGTH: 120 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 53 ggttatggtc
ctgtctgccc tcctggtggc atacaagaag tcactatcaa ccagagccct 60
cttcagcccc tcaatgtgga gattgaccct gagatccaaa aggtgaagtc tcgagaaagg
120 <210> SEQ ID NO 54 <211> LENGTH: 40 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 54 Gly Tyr Gly Pro Val Cys Pro Pro Gly Gly
Ile Gln Glu Val Thr Ile 1 5 10 15 Asn Gln Ser Pro Leu Gln Pro Leu
Asn Val Glu Ile Asp Pro Glu Ile 20 25 30 Gln Lys Val Lys Ser Arg
Glu Arg 35 40 <210> SEQ ID NO 55 <211> LENGTH: 180
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 55 gtctccctgg ctgaggatcc
ccagggagat gctgcccaga agacagatac atcccaccat 60 gatcaggatc
acccaacctt caacaagatc acccccaacc cggctgagtt cgccttcagc 120
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc
180 <210> SEQ ID NO 56 <211> LENGTH: 60 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 56 Val Ser Leu Ala Glu Asp Pro Gln Gly Asp
Ala Ala Gln Lys Thr Asp 1 5 10 15 Thr Ser His His Asp Gln Asp His
Pro Thr Phe Asn Lys Ile Thr Pro 20 25 30 Asn Pro Ala Glu Phe Ala
Phe Ser Leu Tyr Arg Gln Leu Ala His Gln 35 40 45 Ser Asn Ser Thr
Asn Ile Phe Phe Ser Pro Val Ser 50 55 60 <210> SEQ ID NO 57
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 57
ggccactgcc tcattatcaa caatgtgaac ttctgccgtg agtccgggct ccgcacccgc
60 actggctcca acatcgactg tgagaagttg cggcgtcgct tctcctcgcc
gcatttcatg 120 gtggaggtga agggcgacct gactgccaag aaaatggtgc
tggctttgct ggagctggcg 180 <210> SEQ ID NO 58 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 58 Gly His Cys Leu Ile
Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 1 5 10 15 Leu Arg Thr
Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 20 25 30 Arg
Phe Ser Ser Pro His Phe Met Val Glu Val Lys Gly Asp Leu Thr 35 40
45 Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala 50 55 60
<210> SEQ ID NO 59 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 59 actagagcta gatactttct agttgggagc aataatgcag aaacgaaata
tcgtgtcttg 60 aagactgata gaacagaacc aaaagatttg gtcataattg
atgacaggca tgtctatact 120 caacaagaag taagggaact tcttggccgc
ttggatcttg gaaatagaac aaagatggga 180 <210> SEQ ID NO 60
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 60 Thr Arg
Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala Glu Thr Lys 1 5 10 15
Tyr Arg Val Leu Lys Thr Asp Arg Thr Glu Pro Lys Asp Leu Val Ile 20
25 30 Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg Glu Leu
Leu 35 40 45 Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly 50 55
60 <210> SEQ ID NO 61 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 61 acagatgccc cggtgagccc caccactctg
tatgtggagg acatctcgga accgccgttg 60 cacgatttct accgcagcag
gctactggac ctggtcttcc tgctggatgg ctcctccagg 120 ctgtccgagg
ctgagtttga agtgctgaag gcctttgtgg tggacatgat ggagcggctg 180
<210> SEQ ID NO 62 <211> LENGTH: 60 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 62 Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val Glu
Asp Ile Ser 1 5 10 15 Glu Pro Pro Leu His Asp Phe Tyr Arg Ser Arg
Leu Leu Asp Leu Val 20 25 30 Phe Leu Leu Asp Gly Ser Ser Arg Leu
Ser Glu Ala Glu Phe Glu Val 35 40 45 Leu Lys Ala Phe Val Val Asp
Met Met Glu Arg Leu 50 55 60 <210> SEQ ID NO 63 <211>
LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 63 atctgtgctg
ctgtcctcag caaattcatg tctgtgttct gcggggtata tgagcagcca 60
tactactact ctgatatcct gacggtgggc tgtgctgtgg gagtcggccg ttgttttggg
120 acaccacttg gaggagtgct atttagcatc gaggtcacct ccacctactt
tgctgttcgg 180 <210> SEQ ID NO 64 <211> LENGTH: 60
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polypeptide <400> SEQUENCE: 64 Ile Cys Ala Ala Val Leu Ser
Lys Phe Met Ser Val Phe Cys Gly Val 1 5 10 15 Tyr Glu Gln Pro Tyr
Tyr Tyr Ser Asp Ile Leu Thr Val Gly Cys Ala 20 25 30 Val Gly Val
Gly Arg Cys Phe Gly Thr Pro Leu Gly Gly Val Leu Phe 35 40 45 Ser
Ile Glu Val Thr Ser Thr Tyr Phe Ala Val Arg 50 55 60 <210>
SEQ ID NO 65 <211> LENGTH: 180 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 65 tactttgaaa agtcaaagga gcagctgaca cccctgatca agaaggctgg
aacggaactg 60 gttaacttct tgagctattt cgtggaactt ggaacacagc
ctgccaccca gcgaagtgtc 120 cagcaccatt gtcttccaac cccagctggc
ctctagaaca cccactggcc agtcctagag 180 <210> SEQ ID NO 66
<211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 66 Tyr Phe
Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala 1 5 10 15
Gly Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr 20
25 30 Gln Pro Ala Thr Gln Arg Ser Val Gln His His Cys Leu Pro Thr
Pro 35 40 45 Ala Gly Leu Asn Thr His Trp Pro Val Leu Glu 50 55
<210> SEQ ID NO 67 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 67 ccgcacaagc gcctcacgct cagcggcatc tgcgccttca ttagtgaccg
cttcccctac 60 taccgccgca agttccccgc ccggcagaac agcatccgcc
acaacctctc gctgaacgac 120 tgcttcgtca agatcccccg cgagccgggc
cgcccaggca agggcaacta ctggagcctg 180 <210> SEQ ID NO 68
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 68 Pro His
Lys Arg Leu Thr Leu Ser Gly Ile Cys Ala Phe Ile Ser Asp 1 5 10 15
Arg Phe Pro Tyr Tyr Arg Arg Lys Phe Pro Ala Arg Gln Asn Ser Ile 20
25 30 Arg His Asn Leu Ser Leu Asn Asp Cys Phe Val Lys Ile Pro Arg
Glu 35 40 45 Pro Gly Arg Pro Gly Lys Gly Asn Tyr Trp Ser Leu 50 55
60 <210> SEQ ID NO 69 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 69 gctgaggacc tgtggctgag cccgctgacc
atggaagatc ttgtctgcta cagcttccag 60 gtggccagag ggatggagtt
cctggcttcc cgaaagtgca tccgcagaga cctggctgct 120 cggaacattc
tgctgtcgga aagcgacgtg gtgaagatct gtgactttgg ccttgcccgg 180
<210> SEQ ID NO 70 <211> LENGTH: 60 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 70 Ala Glu Asp Leu Trp Leu Ser Pro Leu Thr Met Glu Asp
Leu Val Cys 1 5 10 15 Tyr Ser Phe Gln Val Ala Arg Gly Met Glu Phe
Leu Ala Ser Arg Lys 20 25 30 Cys Ile Arg Arg Asp Leu Ala Ala Arg
Asn Ile Leu Leu Ser Glu Ser 35 40 45 Asp Val Val Lys Ile Cys Asp
Phe Gly Leu Ala Arg 50 55 60 <210> SEQ ID NO 71 <211>
LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 71 gataccgaga
ctgtgggcca gagagccctg cactcaattc tgaatgctgc catcatgatc 60
agtgtcgttg ttgtcatgac tatcctcctg gtggttctgt ataaatacag gtgctataag
120 gtcatccatg cctggcttat tatatcatct ctattgttgc tgttcttttt
ttcattcatt 180 <210> SEQ ID NO 72 <211> LENGTH: 60
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polypeptide <400> SEQUENCE: 72 Asp Thr Glu Thr Val Gly Gln
Arg Ala Leu His Ser Ile Leu Asn Ala 1 5 10 15 Ala Ile Met Ile Ser
Val Val Val Val Met Thr Ile Leu Leu Val Val 20 25 30 Leu Tyr Lys
Tyr Arg Cys Tyr Lys Val Ile His Ala Trp Leu Ile Ile 35 40 45 Ser
Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 50 55 60 <210>
SEQ ID NO 73 <211> LENGTH: 180 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 73 aagccgagta agccaaaaac caacatgaag cacatggctg gtgctgcagc
agctggggca 60 gtggtggggg gccttggcgg ctacgtgctg ggaagtgcca
tgagcaggcc catcatacat 120 ttcggcagtg actatgagga ccgttactat
cgtgaaaaca tgcaccgtta ccccaaccaa 180 <210> SEQ ID NO 74
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 74 Lys Pro
Ser Lys Pro Lys Thr Asn Met Lys His Met Ala Gly Ala Ala 1 5 10 15
Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr Val Leu Gly Ser 20
25 30 Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp Tyr Glu Asp
Arg 35 40 45 Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 50 55
60 <210> SEQ ID NO 75 <211> LENGTH: 120 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 75 cttcccagcc gagacgtgac agtccttctg
gaaaactatg gcaaattcga aaaggggtgt 60 ttgatttttg ttgtacgttt
cctctttggc ctggtaaacc aggagaggac ctcctacttg 120 <210> SEQ ID
NO 76 <211> LENGTH: 40 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 76
Leu Pro Ser Arg Asp Val Thr Val Leu Leu Glu Asn Tyr Gly Lys Phe 1 5
10 15 Glu Lys Gly Cys Leu Ile Phe Val Val Arg Phe Leu Phe Gly Leu
Val 20 25 30 Asn Gln Glu Arg Thr Ser Tyr Leu 35 40 <210> SEQ
ID NO 77 <211> LENGTH: 180 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polynucleotide <400> SEQUENCE:
77 gtgaagcact tctccccaga ggaactcaaa gttaaggtgt tgggagatgt
gattgaggtg 60 catggaaaac atgaagagcg ccaggatgaa catggtttca
tctccaggga gttccacggg 120 aaataccgga tcccagctga tgtagaccct
ctcaccatta cttcatccct gtcatctgat 180 <210> SEQ ID NO 78
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 78 Val Lys
His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 1 5 10 15
Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 20
25 30 Phe Ile Ser Arg Glu Phe His Gly Lys Tyr Arg Ile Pro Ala Asp
Val 35 40 45 Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp 50 55
60 <210> SEQ ID NO 79 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 79 gagctgcact gtgacaagct gcacgtggat
cctgagaact tcaggctcct gggcaacgtg 60 ctggtctgtg tgccggccca
tcactttggc aaagaattca ccccaccagt gcaggctgcc 120 tatcagaaag
tggtggctgg tgtggctaat gccctggccc acaagtatca ctaagctcgc 180
<210> SEQ ID NO 80 <211> LENGTH: 59 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 80 Glu Leu His Cys Asp Lys Leu His Val Asp Pro Glu Asn
Phe Arg Leu 1 5 10 15 Leu Gly Asn Val Leu Val Cys Val Pro Ala His
His Phe Gly Lys Glu 20 25 30 Phe Thr Pro Pro Val Gln Ala Ala Tyr
Gln Lys Val Val Ala Gly Val 35 40 45 Ala Asn Ala Leu Ala His Lys
Tyr His Ala Arg 50 55 <210> SEQ ID NO 81 <211> LENGTH:
102 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 81 aucggaauct auuuugacuc
guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu 60 ccguuaucaa
cuugaaaaag uggcaccgag ucggugcuuu uu 102 <210> SEQ ID NO 82
<211> LENGTH: 102 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 82
ucggaaucua uuuugacucg guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu
60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102 <210>
SEQ ID NO 83 <211> LENGTH: 102 <212> TYPE: RNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 83 cuuagauaaa acugagcaag guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 84 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 84 aucuauuuug acucguucuc guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 85 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 85 uaaaacugag caagaggcuu guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 86 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 86 ugguggcugg acaacaaaaa guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 87 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 87 gcuggacaac aaaaauggau guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 88 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 88 guguuaauuu gucguacgua guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 89 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 89 gcctccgcca acgtggactt cgctttcagc ctgtacaagc agttagtcct
gaaggcccct 60 gataagaatg tcatcttctc cccaccgagc atctccaccg
ccttggcctt cctgtctctg 120 ggggcccata ataccaccct gacagagatt
ctcaaaggcc tcaagttcta cctcacggag 180 <210> SEQ ID NO 90
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 90 Ala Ser
Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Val 1 5 10 15
Leu Lys Ala Pro Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr 20
25 30 Lys Gln Leu Val Leu Lys Ala Pro Gly Ala His Asn Thr Thr Leu
Thr 35 40 45 Glu Ile Leu Lys Gly Leu Lys Phe Tyr Leu Thr Glu 50 55
60 <210> SEQ ID NO 91 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 91 Gly Gly Gly Gly Ser 1 5 <210> SEQ ID NO 92
<211> LENGTH: 1636 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 92
Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Thr Ser Glu Lys 1 5
10 15 Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro
Trp 20 25 30 Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys
Glu Ala Cys 35 40 45 Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg
Lys Ile Trp Arg Ser 50 55 60 Ser Gly Lys Asn Thr Thr Asn His Val
Glu Val Asn Phe Ile Lys Lys 65 70 75 80 Phe Thr Ser Glu Arg Asp Phe
His Pro Ser Met Ser Cys Ser Ile Thr 85 90 95 Trp Phe Leu Ser Trp
Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg 100 105 110 Glu Phe Leu
Ser Arg His Pro Gly Val Thr Leu Val Ile Tyr Val Ala 115 120 125 Arg
Leu Phe Trp His Met Asp Gln Gln Asn Arg Gln Gly Leu Arg Asp 130 135
140 Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr
145 150 155 160 Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly
Asp Glu Ala 165 170 175 His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met
Leu Tyr Ala Leu Glu 180 185 190 Leu His Cys Ile Ile Leu Ser Leu Pro
Pro Cys Leu Lys Ile Ser Arg 195 200 205 Arg Trp Gln Asn His Leu Thr
Phe Phe Arg Leu His Leu Gln Asn Cys 210 215 220 His Tyr Gln Thr Ile
Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile 225 230 235 240 His Pro
Ser Val Ala Trp Arg Ser Pro Lys Lys Lys Arg Lys Val Glu 245 250 255
Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Lys Lys 260
265 270 Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala
Val 275 280 285 Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys
Val Leu Gly 290 295 300 Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu
Ile Gly Ala Leu Leu 305 310 315 320 Phe Asp Ser Gly Glu Thr Ala Glu
Ala Thr Arg Leu Lys Arg Thr Ala 325 330 335 Arg Arg Arg Tyr Thr Arg
Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 340 345 350 Ile Phe Ser Asn
Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 355 360 365 Leu Glu
Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 370 375 380
Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 385
390 395 400 Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr
Asp Lys 405 410 415 Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
Met Ile Lys Phe 420 425 430 Arg Gly His Phe Leu Ile Glu Gly Asp Leu
Asn Pro Asp Asn Ser Asp 435 440 445 Val Asp Lys Leu Phe Ile Gln Leu
Val Gln Thr Tyr Asn Gln Leu Phe 450 455 460 Glu Glu Asn Pro Ile Asn
Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 465 470 475 480 Ser Ala Arg
Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 485 490 495 Leu
Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 500 505
510 Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu
515 520 525 Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp
Leu Asp 530 535 540 Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp
Leu Phe Leu Ala 545 550 555 560 Ala Lys Asn Leu Ser Asp Ala Ile Leu
Leu Ser Asp Ile Leu Arg Val 565 570 575 Asn Thr Glu Ile Thr Lys Ala
Pro Leu Ser Ala Ser Met Ile Lys Arg 580 585 590 Tyr Asp Glu His His
Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 595 600 605 Gln Gln Leu
Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 610 615 620 Asn
Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 625 630
635 640 Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu
Glu 645 650 655 Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys
Gln Arg Thr 660 665 670 Phe Asp Asn Gly Ser Ile Pro His Gln Ile His
Leu Gly Glu Leu His 675 680 685 Ala Ile Leu Arg Arg Gln Glu Asp Phe
Tyr Pro Phe Leu Lys Asp Asn 690 695 700 Arg Glu Lys Ile Glu Lys Ile
Leu Thr Phe Arg Ile Pro Tyr Tyr Val 705 710 715 720 Gly Pro Leu Ala
Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 725 730 735 Ser Glu
Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 740 745 750
Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 755
760 765 Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr
Glu 770 775 780 Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr
Val Thr Glu 785 790 795 800 Gly Met Arg Lys Pro Ala Phe Leu Ser Gly
Glu Gln Lys Lys Ala Ile 805 810 815 Val Asp Leu Leu Phe Lys Thr Asn
Arg Lys Val Thr Val Lys Gln Leu 820 825 830 Lys Glu Asp Tyr Phe Lys
Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 835 840 845 Ser Gly Val Glu
Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 850 855 860 Leu Leu
Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 865 870 875
880 Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp
885 890 895 Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu
Phe Asp 900 905 910 Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr
Thr Gly Trp Gly 915 920 925 Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile
Arg Asp Lys Gln Ser Gly 930 935 940 Lys Thr Ile Leu Asp Phe Leu Lys
Ser Asp Gly Phe Ala Asn Arg Asn 945 950 955 960 Phe Met Gln Leu Ile
His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 965 970 975 Gln Lys Ala
Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 980 985 990 Ala
Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 995
1000 1005 Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His
Lys 1010 1015 1020 Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn
Gln Thr Thr 1025 1030 1035 Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg
Met Lys Arg Ile Glu 1040 1045 1050 Glu Gly Ile Lys Glu Leu Gly Ser
Gln Ile Leu Lys Glu His Pro 1055 1060 1065 Val Glu Asn Thr Gln Leu
Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 1070 1075 1080 Leu Gln Asn Gly
Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 1085 1090 1095 Asn Arg
Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 1100 1105 1110
Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 1115
1120 1125 Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu
Val 1130 1135 1140 Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu
Asn Ala Lys 1145 1150 1155 Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu
Thr Lys Ala Glu Arg 1160 1165 1170 Gly Gly Leu Ser Glu Leu Asp Lys
Ala Gly Phe Ile Lys Arg Gln 1175 1180 1185 Leu Val Glu Thr Arg Gln
Ile Thr Lys His Val Ala Gln Ile Leu 1190 1195 1200 Asp Ser Arg Met
Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile 1205 1210 1215 Arg Glu
Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 1220 1225 1230
Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn 1235
1240 1245 Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly
Thr 1250 1255 1260 Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu
Phe Val Tyr 1265 1270 1275 Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys
Met Ile Ala Lys Ser 1280 1285 1290 Glu Gln Glu Ile Gly Lys Ala Thr
Ala Lys Tyr Phe Phe Tyr Ser 1295 1300 1305 Asn Ile Met Asn Phe Phe
Lys Thr Glu Ile Thr Leu Ala Asn Gly 1310 1315 1320 Glu Ile Arg Lys
Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly 1325 1330 1335 Glu Ile
Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys 1340 1345 1350
Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val 1355
1360 1365 Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg
Asn 1370 1375 1380 Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp
Pro Lys Lys 1385 1390 1395 Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala
Tyr Ser Val Leu Val 1400 1405 1410 Val Ala Lys Val Glu Lys Gly Lys
Ser Lys Lys Leu Lys Ser Val 1415 1420 1425 Lys Glu Leu Leu Gly Ile
Thr Ile Met Glu Arg Ser Ser Phe Glu 1430 1435 1440 Lys Asn Pro Ile
Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val 1445 1450 1455 Lys Lys
Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 1460 1465 1470
Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu 1475
1480 1485 Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn
Phe 1490 1495 1500 Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly
Ser Pro Glu 1505 1510 1515 Asp Asn Glu Gln Lys Gln Leu Phe Val Glu
Gln His Lys His Tyr 1520 1525 1530 Leu Asp Glu Ile Ile Glu Gln Ile
Ser Glu Phe Ser Lys Arg Val 1535 1540 1545 Ile Leu Ala Asp Ala Asn
Leu Asp Lys Val Leu Ser Ala Tyr Asn 1550 1555 1560 Lys His Arg Asp
Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile 1565 1570 1575 His Leu
Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys 1580 1585 1590
Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys 1595
1600 1605 Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly
Leu 1610 1615 1620 Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly
Asp 1625 1630 1635
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 92 <210>
SEQ ID NO 1 <211> LENGTH: 4104 <212> TYPE: DNA
<213> ORGANISM: Streptococcus pyogenes <400> SEQUENCE:
1 atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg
60 atcactgatg attataaggt tccgtctaaa aagttcaagg ttctgggaaa
tacagaccgc 120 cacagtatca aaaaaaatct tataggggct cttttatttg
gcagtggaga gacagcggaa 180 gcgactcgtc tcaaacggac agctcgtaga
aggtatacac gtcggaagaa tcgtatttgt 240 tatctacagg agattttttc
aaatgagatg gcgaaagtag atgatagttt ctttcatcga 300 cttgaagagt
cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga 360
aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa
420 aaattggcag attctactga taaagcggat ttgcgcttaa tctatttggc
cttagcgcat 480 atgattaagt ttcgtggtca ttttttgatt gagggagatt
taaatcctga taatagtgat 540 gtggacaaac tatttatcca gttggtacaa
atctacaatc aattatttga agaaaaccct 600 attaacgcaa gtagagtaga
tgctaaagcg attctttctg cacgattgag taaatcaaga 660 cgattagaaa
atctcattgc tcagctcccc ggtgagaaga gaaatggctt gtttgggaat 720
ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa
780 gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa
tttattggcg 840 caaattggag atcaatatgc tgatttgttt ttggcagcta
agaatttatc agatgctatt 900 ttactttcag atatcctaag agtaaatagt
gaaataacta aggctcccct atcagcttca 960 atgattaagc gctacgatga
acatcatcaa gacttgactc ttttaaaagc tttagttcga 1020 caacaacttc
cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca 1080
ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta
1140 gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga
tttgctgcgc 1200 aagcaacgga cctttgacaa cggctctatt ccccatcaaa
ttcacttggg tgagctgcat 1260 gctattttga gaagacaaga agacttttat
ccatttttaa aagacaatcg tgagaagatt 1320 gaaaaaatct tgacttttcg
aattccttat tatgttggtc cattggcgcg tggcaatagt 1380 cgttttgcat
ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa 1440
gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa
1500 aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta
ttttacggtt 1560 tataacgaat tgacaaaggt caaatatgtt actgagggaa
tgcgaaaacc agcatttctt 1620 tcaggtgaac agaagaaagc cattgttgat
ttactcttca aaacaaatcg aaaagtaacc 1680 gttaagcaat taaaagaaga
ttatttcaaa aaaatagaat gttttgatag tgttgaaatt 1740 tcaggagttg
aagatagatt taatgcttca ttaggcgcct accatgattt gctaaaaatt 1800
attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt
1860 ttaacattga ccttatttga agataggggg atgattgagg aaagacttaa
aacatatgct 1920 cacctctttg atgataaggt gatgaaacag cttaaacgtc
gccgttatac tggttgggga 1980 cgtttgtctc gaaaattgat taatggtatt
agggataagc aatctggcaa aacaatatta 2040 gattttttga aatcagatgg
ttttgccaat cgcaatttta tgcagctgat ccatgatgat 2100 agtttgacat
ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg ccatagttta 2160
catgaacaga ttgctaactt agctggcagt cctgctatta aaaaaggtat tttacagact
2220 gtaaaaattg ttgatgaact ggtcaaagta atggggcata agccagaaaa
tatcgttatt 2280 gaaatggcac gtgaaaatca gacaactcaa aagggccaga
aaaattcgcg agagcgtatg 2340 aaacgaatcg aagaaggtat caaagaatta
ggaagtcaga ttcttaaaga gcatcctgtt 2400 gaaaatactc aattgcaaaa
tgaaaagctc tatctctatt atctacaaaa tggaagagac 2460 atgtatgtgg
accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt 2520
gttccacaaa gtttcattaa agacgattca atagacaata aggtactaac gcgttctgat
2580 aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa
gatgaaaaac 2640 tattggagac aacttctaaa cgccaagtta atcactcaac
gtaagtttga taatttaacg 2700 aaagctgaac gtggaggttt gagtgaactt
gataaagctg gttttatcaa acgccaattg 2760 gttgaaactc gccaaatcac
taagcatgtg gcacaaattt tggatagtcg catgaatact 2820 aaatacgatg
aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa 2880
ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac
2940 catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat
taagaaatat 3000 ccaaaacttg aatcggagtt tgtctatggt gattataaag
tttatgatgt tcgtaaaatg 3060 attgctaagt ctgagcaaga aataggcaaa
gcaaccgcaa aatatttctt ttactctaat 3120 atcatgaact tcttcaaaac
agaaattaca cttgcaaatg gagagattcg caaacgccct 3180 ctaatcgaaa
ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc 3240
acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag
3300 acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa
gcttattgct 3360 cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg
atagtccaac ggtagcttat 3420 tcagtcctag tggttgctaa ggtggaaaaa
gggaaatcga agaagttaaa atccgttaaa 3480 gagttactag ggatcacaat
tatggaaaga agttcctttg aaaaaaatcc gattgacttt 3540 ttagaagcta
aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat 3600
agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa
3660 aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt
agctagtcat 3720 tatgaaaagt tgaagggtag tccagaagat aacgaacaaa
aacaattgtt tgtggagcag 3780 cataagcatt atttagatga gattattgag
caaatcagtg aattttctaa gcgtgttatt 3840 ttagcagatg ccaatttaga
taaagttctt agtgcatata acaaacatag agacaaacca 3900 atacgtgaac
aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc 3960
gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa
4020 gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac
acgcattgat 4080 ttgagtcagc taggaggtga ctga 4104 <210> SEQ ID
NO 2 <211> LENGTH: 1367 <212> TYPE: PRT <213>
ORGANISM: Streptococcus pyogenes <400> SEQUENCE: 2 Met Asp
Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15
Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20
25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu
Ile 35 40 45 Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala
Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg
Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu
Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu
Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro
Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys
Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser
Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150
155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn
Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val
Gln Ile Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala
Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser
Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly
Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu
Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu
Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270
Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275
280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser
Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu
Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln
Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro
Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly
Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe
Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr
Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395
400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu
405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr
Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu
Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly
Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr
Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly
Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr
485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys
His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu
Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala
Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu
Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys
Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu
Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Ala
Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600
605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr
610 615 620 Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr
Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu
Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys
Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile
Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe
Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp
Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 705 710 715 720
His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725
730 735 Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met
Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu
Asn Gln Thr 755 760 765 Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg
Met Lys Arg Ile Glu 770 775 780 Glu Gly Ile Lys Glu Leu Gly Ser Gln
Ile Leu Lys Glu His Pro Val 785 790 795 800 Glu Asn Thr Gln Leu Gln
Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 805 810 815 Asn Gly Arg Asp
Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 820 825 830 Ser Asp
Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 835 840 845
Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850
855 860 Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys
Asn 865 870 875 880 Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr
Gln Arg Lys Phe 885 890 895 Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly
Leu Ser Glu Leu Asp Lys 900 905 910 Ala Gly Phe Ile Lys Arg Gln Leu
Val Glu Thr Arg Gln Ile Thr Lys 915 920 925 His Val Ala Gln Ile Leu
Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 930 935 940 Asn Asp Lys Leu
Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 945 950 955 960 Leu
Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 965 970
975 Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val
980 985 990 Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu
Phe Val 995 1000 1005 Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys
Met Ile Ala Lys 1010 1015 1020 Ser Glu Gln Glu Ile Gly Lys Ala Thr
Ala Lys Tyr Phe Phe Tyr 1025 1030 1035 Ser Asn Ile Met Asn Phe Phe
Lys Thr Glu Ile Thr Leu Ala Asn 1040 1045 1050 Gly Glu Ile Arg Lys
Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr 1055 1060 1065 Gly Glu Ile
Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 1070 1075 1080 Lys
Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu 1085 1090
1095 Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg
1100 1105 1110 Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp
Pro Lys 1115 1120 1125 Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala
Tyr Ser Val Leu 1130 1135 1140 Val Val Ala Lys Val Glu Lys Gly Lys
Ser Lys Lys Leu Lys Ser 1145 1150 1155 Val Lys Glu Leu Leu Gly Ile
Thr Ile Met Glu Arg Ser Ser Phe 1160 1165 1170 Glu Lys Asn Pro Ile
Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 1175 1180 1185 Val Lys Lys
Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 1190 1195 1200 Glu
Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu 1205 1210
1215 Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn
1220 1225 1230 Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly
Ser Pro 1235 1240 1245 Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu
Gln His Lys His 1250 1255 1260 Tyr Leu Asp Glu Ile Ile Glu Gln Ile
Ser Glu Phe Ser Lys Arg 1265 1270 1275 Val Ile Leu Ala Asp Ala Asn
Leu Asp Lys Val Leu Ser Ala Tyr 1280 1285 1290 Asn Lys His Arg Asp
Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile 1295 1300 1305 Ile His Leu
Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 1310 1315 1320 Lys
Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr 1325 1330
1335 Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly
1340 1345 1350 Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly
Asp 1355 1360 1365 <210> SEQ ID NO 3 <211> LENGTH: 4212
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 3 atggataaaa agtattctat
tggtttagac atcggcacta attccgttgg atgggctgtc 60 ataaccgatg
aatacaaagt accttcaaag aaatttaagg tgttggggaa cacagaccgt 120
cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga aacggcagag
180 gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa
ccgaatatgt 240 tacttacaag aaatttttag caatgagatg gccaaagttg
acgattcttt ctttcaccgt 300 ttggaagagt ccttccttgt cgaagaggac
aagaaacatg aacggcaccc catctttgga 360 aacatagtag atgaggtggc
atatcatgaa aagtacccaa cgatttatca cctcagaaaa 420 aagctagttg
actcaactga taaagcggac ctgaggttaa tctacttggc tcttgcccat 480
atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga caactcggat
540 gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga
agagaaccct 600 ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg
cccgcctctc taaatcccga 660 cggctagaaa acctgatcgc acaattaccc
ggagagaaga aaaatgggtt gttcggtaac 720 cttatagcgc tctcactagg
cctgacacca aattttaagt cgaacttcga cttagctgaa 780 gatgccaaat
tgcagcttag taaggacacg tacgatgacg atctcgacaa tctactggca 840
caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag cgatgcaatc
900 ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt
atccgcttca 960 atgatcaaaa ggtacgatga acatcaccaa gacttgacac
ttctcaaggc cctagtccgt 1020 cagcaactgc ctgagaaata taaggaaata
ttctttgatc agtcgaaaaa cgggtacgca 1080 ggttatattg acggcggagc
gagtcaagag gaattctaca agtttatcaa acccatatta 1140 gagaagatgg
atgggacgga agagttgctt gtaaaactca atcgcgaaga tctactgcga 1200
aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg cgaattgcat
1260 gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg
tgaaaagatt 1320 gagaaaatcc taacctttcg cataccttac tatgtgggac
ccctggcccg agggaactct 1380 cggttcgcat ggatgacaag aaagtccgaa
gaaacgatta ctccatggaa ttttgaggaa 1440 gttgtcgata aaggtgcgtc
agctcaatcg ttcatcgaga ggatgaccaa ctttgacaag 1500 aatttaccga
acgaaaaagt attgcctaag cacagtttac tttacgagta tttcacagtg 1560
tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc cgcctttcta
1620 agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg
caaagtgaca 1680 gttaagcaat tgaaagagga ctactttaag aaaattgaat
gcttcgattc tgtcgagatc 1740 tccggggtag aagatcgatt taatgcgtca
cttggtacgt atcatgacct cctaaagata 1800 attaaagata aggacttcct
ggataacgaa gagaatgaag atatcttaga agatatagtg 1860 ttgactctta
ccctctttga agatcgggaa atgattgagg aaagactaaa aacatacgct 1920
cacctgttcg acgataaggt tatgaaacag ttaaagaggc gtcgctatac gggctgggga
1980 cgattgtcgc ggaaacttat caacgggata agagacaagc aaagtggtaa
aactattctc 2040 gattttctaa agagcgacgg cttcgccaat aggaacttta
tgcagctgat ccatgatgac 2100 tctttaacct tcaaagagga tatacaaaag
gcacaggttt ccggacaagg ggactcattg 2160
cacgaacata ttgcgaatct tgctggttcg ccagccatca aaaagggcat actccagaca
2220 gtcaaagtag tggatgagct agttaaggtc atgggacgtc acaaaccgga
aaacattgta 2280 atcgagatgg cacgcgaaaa tcaaacgact cagaaggggc
aaaaaaacag tcgagagcgg 2340 atgaagagaa tagaagaggg tattaaagaa
ctgggcagcc agatcttaaa ggagcatcct 2400 gtggaaaata cccaattgca
gaacgagaaa ctttacctct attacctaca aaatggaagg 2460 gacatgtatg
ttgatcagga actggacata aaccgtttat ctgattacga cgtcgatcac 2520
attgtacccc aatccttttt gaaggacgat tcaatcgaca ataaagtgct tacacgctcg
2580 gataagaacc gagggaaaag tgacaatgtt ccaagcgagg aagtcgtaaa
gaaaatgaag 2640 aactattggc ggcagctcct aaatgcgaaa ctgataacgc
aaagaaagtt cgataactta 2700 actaaagctg agaggggtgg cttgtctgaa
cttgacaagg ccggatttat taaacgtcag 2760 ctcgtggaaa cccgccaaat
cacaaagcat gttgcacaga tactagattc ccgaatgaat 2820 acgaaatacg
acgagaacga taagctgatt cgggaagtca aagtaatcac tttaaagtca 2880
aaattggtgt cggacttcag aaaggatttt caattctata aagttaggga gataaataac
2940 taccaccatg cgcacgacgc ttatcttaat gccgtcgtag ggaccgcact
cattaagaaa 3000 tacccgaagc tagaaagtga gtttgtgtat ggtgattaca
aagtttatga cgtccgtaag 3060 atgatcgcga aaagcgaaca ggagataggc
aaggctacag ccaaatactt cttttattct 3120 aacattatga atttctttaa
gacggaaatc actctggcaa acggagagat acgcaaacga 3180 cctttaattg
aaaccaatgg ggagacaggt gaaatcgtat gggataaggg ccgggacttc 3240
gcgacggtga gaaaagtttt gtccatgccc caagtcaaca tagtaaagaa aactgaggtg
3300 cagaccggag ggttttcaaa ggaatcgatt cttccaaaaa ggaatagtga
taagctcatc 3360 gctcgtaaaa aggactggga cccgaaaaag tacggtggct
tcgatagccc tacagttgcc 3420 tattctgtcc tagtagtggc aaaagttgag
aagggaaaat ccaagaaact gaagtcagtc 3480 aaagaattat tggggataac
gattatggag cgctcgtctt ttgaaaagaa ccccatcgac 3540 ttccttgagg
cgaaaggtta caaggaagta aaaaaggatc tcataattaa actaccaaag 3600
tatagtctgt ttgagttaga aaatggccga aaacggatgt tggctagcgc cggagagctt
3660 caaaagggga acgaactcgc actaccgtct aaatacgtga atttcctgta
tttagcgtcc 3720 cattacgaga agttgaaagg ttcacctgaa gataacgaac
agaagcaact ttttgttgag 3780 cagcacaaac attatctcga cgaaatcata
gagcaaattt cggaattcag taagagagtc 3840 atcctagctg atgccaatct
ggacaaagta ttaagcgcat acaacaagca cagggataaa 3900 cccatacgtg
agcaggcgga aaatattatc catttgttta ctcttaccaa cctcggcgct 3960
ccagccgcat tcaagtattt tgacacaacg atagatcgca aacgatacac ttctaccaag
4020 gaggtgctag acgcgacact gattcaccaa tccatcacgg gattatatga
aactcggata 4080 gatttgtcac agcttggggg tgacggatcc cccaagaaga
agaggaaagt ctcgagcgac 4140 tacaaagacc atgacggtga ttataaagat
catgacatcg attacaagga tgacgatgac 4200 aaggctgcag ga 4212
<210> SEQ ID NO 4 <211> LENGTH: 1368 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 4 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn
Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro
Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser
Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly
Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg
Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu
Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe
His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110
His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115
120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val
Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala
Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile
Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu
Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu
Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu
Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile
Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235
240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe
245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr
Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp
Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp
Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile
Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr
Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val
Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp
Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360
365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp
370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu
Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro
His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg
Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys
Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly
Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg
Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480
Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485
490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His
Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr
Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe
Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe
Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu
Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile
Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr
His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605
Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610
615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr
Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys
Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu
Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu
Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met
Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile
Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His
Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730
735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly
740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu
Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg
Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln
Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln
Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp
Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp
Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp
Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855
860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys
865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr
Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly
Leu Ser Glu Leu Asp 900 905 910
Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915
920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr
Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr
Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe
Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala
His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile
Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly
Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys
Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030
1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala
1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn
Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp
Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val
Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe
Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys
Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr
Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu
Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150
1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser
1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly
Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro
Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg
Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu
Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu
Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp
Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His
Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270
1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala
1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala
Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly
Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp
Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala
Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr
Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210>
SEQ ID NO 5 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 5
Glu Ala Ala Ala Lys 1 5 <210> SEQ ID NO 6 <211> LENGTH:
198 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 6 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe
Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg Arg
Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Ala
Thr Ser Phe Ser Leu Asp Phe Gly Tyr 35 40 45 Leu Arg Asn Lys Asn
Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp
Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe
Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 85 90
95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg
100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu
Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr
Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn
His Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu His Glu
Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg Arg Ile Leu Leu
Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe Arg Thr
Leu Gly Leu 195 <210> SEQ ID NO 7 <211> LENGTH: 198
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 7 Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe
Leu Tyr His Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg His
Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Ala
Thr Ser Cys Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys Ser
Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp
Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe
Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 85 90
95 Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg
100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu
Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr
Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn
Arg Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu His Glu
Asn Ser Val Arg Leu Thr Arg Gln Leu 165 170 175 Arg Arg Ile Leu Leu
Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe Arg Met
Leu Gly Phe 195 <210> SEQ ID NO 8 <211> LENGTH: 198
<212> TYPE: PRT <213> ORGANISM: Canis lupus <400>
SEQUENCE: 8 Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His
Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr
Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Ala Thr Ser Phe
Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys Ser Gly Cys His
Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu
Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp
Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 85 90 95 Phe Leu
Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 100 105 110
Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 115
120 125 Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp
Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys
Thr Phe Lys 145 150 155 160 Ala Trp Glu Gly Leu His Glu Asn Ser Val
Arg Leu Ser Arg Gln Leu 165 170 175 Arg Arg Ile Leu Leu Pro Leu Tyr
Glu Val Asp Asp Leu Arg Asp Ala 180 185 190 Phe Arg Thr Leu Gly Leu
195 <210> SEQ ID NO 9 <211> LENGTH: 199 <212>
TYPE: PRT <213> ORGANISM: Bos taurus
<400> SEQUENCE: 9 Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe
Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg His
Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg Arg Asp Ser Pro
Thr Ser Phe Ser Leu Asp Phe Gly His 35 40 45 Leu Arg Asn Lys Ala
Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55 60 Ile Ser Asp
Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe
Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 85 90
95 Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg
100 105 110 Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly
Leu Arg 115 120 125 Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met
Thr Phe Lys Asp 130 135 140 Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu
Asn His Glu Arg Thr Phe 145 150 155 160 Lys Ala Trp Glu Gly Leu His
Glu Asn Ser Val Arg Leu Ser Arg Gln 165 170 175 Leu Arg Arg Ile Leu
Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 180 185 190 Ala Phe Arg
Thr Leu Gly Leu 195 <210> SEQ ID NO 10 <211> LENGTH:
429 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 10 Met Gly Pro Phe Cys Leu Gly Cys Ser His
Arg Lys Cys Tyr Ser Pro 1 5 10 15 Ile Arg Asn Leu Ile Ser Gln Glu
Thr Phe Lys Phe His Phe Lys Asn 20 25 30 Leu Gly Tyr Ala Lys Gly
Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 35 40 45 Thr Arg Lys Asp
Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 50 55 60 Lys Asn
Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 65 70 75 80
His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 85
90 95 Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln
Ile 100 105 110 Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp
Ile Phe Ser 115 120 125 Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr
Gln Gln Asn Leu Cys 130 135 140 Arg Leu Val Gln Glu Gly Ala Gln Val
Ala Ala Met Asp Leu Tyr Glu 145 150 155 160 Phe Lys Lys Cys Trp Lys
Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 165 170 175 Arg Pro Trp Lys
Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 180 185 190 Leu Gln
Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 195 200 205
Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 210
215 220 Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu
Glu 225 230 235 240 Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His
Leu Cys Tyr Tyr 245 250 255 His Arg Met Lys Pro Tyr Leu Cys Tyr Gln
Leu Glu Gln Phe Asn Gly 260 265 270 Gln Ala Pro Leu Lys Gly Cys Leu
Leu Ser Glu Lys Gly Lys Gln His 275 280 285 Ala Glu Ile Leu Phe Leu
Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 290 295 300 Val Thr Ile Thr
Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 305 310 315 320 Trp
Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 325 330
335 Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys
340 345 350 Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val
Met Asp 355 360 365 Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val
Asn Pro Lys Arg 370 375 380 Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile
Ile Ser Arg Arg Thr Gln 385 390 395 400 Arg Arg Leu Arg Arg Ile Lys
Glu Ser Trp Gly Leu Gln Asp Leu Val 405 410 415 Asn Asp Phe Gly Asn
Leu Gln Leu Gly Pro Pro Met Ser 420 425 <210> SEQ ID NO 11
<211> LENGTH: 429 <212> TYPE: PRT <213> ORGANISM:
Rattus norvegicus <400> SEQUENCE: 11 Met Gly Pro Phe Cys Leu
Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 1 5 10 15 Ile Arg Asn Leu
Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 20 25 30 Leu Arg
Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 35 40 45
Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 50
55 60 Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp
Phe 65 70 75 80 His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu
Phe Lys Ile 85 90 95 Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu
Cys Ala Glu Gln Val 100 105 110 Leu Arg Phe Leu Ala Thr His His Asn
Leu Ser Leu Asp Ile Phe Ser 115 120 125 Ser Arg Leu Tyr Asn Ile Arg
Asp Pro Glu Asn Gln Gln Asn Leu Cys 130 135 140 Arg Leu Val Gln Glu
Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 145 150 155 160 Phe Lys
Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 165 170 175
Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 180
185 190 Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser
Ser 195 200 205 Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu
Pro Glu Thr 210 215 220 Arg Phe Cys Val Glu Arg Arg Arg Val His Leu
Leu Ser Glu Glu Glu 225 230 235 240 Phe Tyr Ser Gln Phe Tyr Asn Gln
Arg Val Lys His Leu Cys Tyr Tyr 245 250 255 His Gly Val Lys Pro Tyr
Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 260 265 270 Gln Ala Pro Leu
Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 275 280 285 Ala Glu
Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 290 295 300
Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 305
310 315 320 Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile
Leu His 325 330 335 Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg
Pro Phe Gln Lys 340 345 350 Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile
Leu Val Asp Val Met Asp 355 360 365 Leu Pro Gln Phe Thr Asp Cys Trp
Thr Asn Phe Val Asn Pro Lys Arg 370 375 380 Pro Phe Trp Pro Trp Lys
Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 385 390 395 400 Arg Arg Leu
His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 405 410 415 Asn
Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 420 425 <210>
SEQ ID NO 12 <211> LENGTH: 370 <212> TYPE: PRT
<213> ORGANISM: Macaca mulatta <400> SEQUENCE: 12 Met
Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 1 5 10
15 Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val
20 25 30 Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile
Phe Gln 35 40 45 Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu
Met Arg Phe Leu 50 55 60 Arg Trp Phe His Lys Trp Arg Gln Leu His
His Asp Gln Glu Tyr Lys 65 70 75 80 Val Thr Trp Tyr Val Ser Trp Ser
Pro Cys Thr Arg Cys Ala Asn Ser 85 90 95 Val Ala Thr Phe Leu Ala
Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 100 105 110 Val Ala Arg Leu
Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 115 120 125
Arg Ile Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 130
135 140 Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp
Gly 145 150 155 160 Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro
Lys His Tyr Thr 165 170 175 Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu
Arg His Leu Met Asp Pro 180 185 190 Gly Thr Phe Thr Ser Asn Phe Asn
Asn Lys Pro Trp Val Ser Gly Gln 195 200 205 His Glu Thr Tyr Leu Cys
Tyr Lys Val Glu Arg Leu His Asn Asp Thr 210 215 220 Trp Val Pro Leu
Asn Gln His Arg Gly Phe Leu Arg Asn Gln Ala Pro 225 230 235 240 Asn
Ile His Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 245 250
255 Asp Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr
260 265 270 Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu
Met Ala 275 280 285 Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys
Ile Phe Ala Ala 290 295 300 Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln
Glu Gly Leu Arg Ala Leu 305 310 315 320 His Arg Asp Gly Ala Lys Ile
Ala Met Met Asn Tyr Ser Glu Phe Glu 325 330 335 Tyr Cys Trp Asp Thr
Phe Val Asp Arg Gln Gly Arg Pro Phe Gln Pro 340 345 350 Trp Asp Gly
Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 355 360 365 Ala
Ile 370 <210> SEQ ID NO 13 <211> LENGTH: 384
<212> TYPE: PRT <213> ORGANISM: Pan troglodytes
<400> SEQUENCE: 13 Met Lys Pro His Phe Arg Asn Pro Val Glu
Arg Met Tyr Gln Asp Thr 1 5 10 15 Phe Ser Asp Asn Phe Tyr Asn Arg
Pro Ile Leu Ser His Arg Asn Thr 20 25 30 Val Trp Leu Cys Tyr Glu
Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 35 40 45 Leu Asp Ala Lys
Ile Phe Arg Gly Gln Val Tyr Ser Lys Leu Lys Tyr 50 55 60 His Pro
Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 65 70 75 80
His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 85
90 95 Cys Thr Lys Cys Thr Arg Asp Val Ala Thr Phe Leu Ala Glu Asp
Pro 100 105 110 Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr
Phe Trp Asp 115 120 125 Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys
Gln Lys Arg Asp Gly 130 135 140 Pro Arg Ala Thr Met Lys Ile Met Asn
Tyr Asp Glu Phe Gln His Cys 145 150 155 160 Trp Ser Lys Phe Val Tyr
Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 165 170 175 Asn Leu Pro Lys
Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 180 185 190 Leu Arg
His Ser Met Asp Pro Pro Thr Phe Thr Ser Asn Phe Asn Asn 195 200 205
Glu Leu Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 210
215 220 Glu Arg Leu His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg
Gly 225 230 235 240 Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe
Leu Glu Gly Arg 245 250 255 His Ala Glu Leu Cys Phe Leu Asp Val Ile
Pro Phe Trp Lys Leu Asp 260 265 270 Leu His Gln Asp Tyr Arg Val Thr
Cys Phe Thr Ser Trp Ser Pro Cys 275 280 285 Phe Ser Cys Ala Gln Glu
Met Ala Lys Phe Ile Ser Asn Asn Lys His 290 295 300 Val Ser Leu Cys
Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg 305 310 315 320 Cys
Gln Glu Gly Leu Arg Thr Leu Ala Lys Ala Gly Ala Lys Ile Ser 325 330
335 Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp
340 345 350 His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu
His Ser 355 360 365 Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln
Asn Gln Gly Asn 370 375 380 <210> SEQ ID NO 14 <211>
LENGTH: 377 <212> TYPE: PRT <213> ORGANISM: Chlorocebus
sabaeus <400> SEQUENCE: 14 Met Asn Pro Gln Ile Arg Asn Met
Val Glu Gln Met Glu Pro Asp Ile 1 5 10 15 Phe Val Tyr Tyr Phe Asn
Asn Arg Pro Ile Leu Ser Gly Arg Asn Thr 20 25 30 Val Trp Leu Cys
Tyr Glu Val Lys Thr Lys Asp Pro Ser Gly Pro Pro 35 40 45 Leu Asp
Ala Asn Ile Phe Gln Gly Lys Leu Tyr Pro Glu Ala Lys Asp 50 55 60
His Pro Glu Met Lys Phe Leu His Trp Phe Arg Lys Trp Arg Gln Leu 65
70 75 80 His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Val Ser Trp
Ser Pro 85 90 95 Cys Thr Arg Cys Ala Asn Ser Val Ala Thr Phe Leu
Ala Glu Asp Pro 100 105 110 Lys Val Thr Leu Thr Ile Phe Val Ala Arg
Leu Tyr Tyr Phe Trp Lys 115 120 125 Pro Asp Tyr Gln Gln Ala Leu Arg
Ile Leu Cys Gln Glu Arg Gly Gly 130 135 140 Pro His Ala Thr Met Lys
Ile Met Asn Tyr Asn Glu Phe Gln His Cys 145 150 155 160 Trp Asn Glu
Phe Val Asp Gly Gln Gly Lys Pro Phe Lys Pro Arg Lys 165 170 175 Asn
Leu Pro Lys His Tyr Thr Leu Leu His Ala Thr Leu Gly Glu Leu 180 185
190 Leu Arg His Val Met Asp Pro Gly Thr Phe Thr Ser Asn Phe Asn Asn
195 200 205 Lys Pro Trp Val Ser Gly Gln Arg Glu Thr Tyr Leu Cys Tyr
Lys Val 210 215 220 Glu Arg Ser His Asn Asp Thr Trp Val Leu Leu Asn
Gln His Arg Gly 225 230 235 240 Phe Leu Arg Asn Gln Ala Pro Asp Arg
His Gly Phe Pro Lys Gly Arg 245 250 255 His Ala Glu Leu Cys Phe Leu
Asp Leu Ile Pro Phe Trp Lys Leu Asp 260 265 270 Asp Gln Gln Tyr Arg
Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 275 280 285 Ser Cys Ala
Gln Lys Met Ala Lys Phe Ile Ser Asn Asn Lys His Val 290 295 300 Ser
Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys 305 310
315 320 Gln Glu Gly Leu Arg Thr Leu His Arg Asp Gly Ala Lys Ile Ala
Val 325 330 335 Met Asn Tyr Ser Glu Phe Glu Tyr Cys Trp Asp Thr Phe
Val Asp Arg 340 345 350 Gln Gly Arg Pro Phe Gln Pro Trp Asp Gly Leu
Asp Glu His Ser Gln 355 360 365 Ala Leu Ser Gly Arg Leu Arg Ala Ile
370 375 <210> SEQ ID NO 15 <211> LENGTH: 384
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 15 Met Lys Pro His Phe Arg Asn Thr Val Glu
Arg Met Tyr Arg Asp Thr 1 5 10 15 Phe Ser Tyr Asn Phe Tyr Asn Arg
Pro Ile Leu Ser Arg Arg Asn Thr 20 25 30 Val Trp Leu Cys Tyr Glu
Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 35 40 45 Leu Asp Ala Lys
Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 50 55 60 His Pro
Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 65 70 75 80
His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 85
90 95 Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp
Pro 100 105 110 Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr
Phe Trp Asp 115 120 125 Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys
Gln Lys Arg Asp Gly 130 135 140 Pro Arg Ala Thr Met Lys Ile Met Asn
Tyr Asp Glu Phe Gln His Cys 145 150 155 160 Trp Ser Lys Phe Val Tyr
Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 165 170 175 Asn Leu Pro Lys
Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 180 185 190 Leu Arg
His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn
195 200 205 Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr
Glu Val 210 215 220 Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn
Gln Arg Arg Gly 225 230 235 240 Phe Leu Cys Asn Gln Ala Pro His Lys
His Gly Phe Leu Glu Gly Arg 245 250 255 His Ala Glu Leu Cys Phe Leu
Asp Val Ile Pro Phe Trp Lys Leu Asp 260 265 270 Leu Asp Gln Asp Tyr
Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 275 280 285 Phe Ser Cys
Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 290 295 300 Val
Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 305 310
315 320 Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile
Ser 325 330 335 Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr
Phe Val Asp 340 345 350 His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly
Leu Asp Glu His Ser 355 360 365 Gln Asp Leu Ser Gly Arg Leu Arg Ala
Ile Leu Gln Asn Gln Glu Asn 370 375 380 <210> SEQ ID NO 16
<211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 16 Met Lys Pro His Phe Arg Asn
Thr Val Glu Arg Met Tyr Arg Asp Thr 1 5 10 15 Phe Ser Tyr Asn Phe
Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 20 25 30 Val Trp Leu
Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 35 40 45 Leu
Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 50 55
60 His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro
65 70 75 80 Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr
Pro Cys 85 90 95 Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala
Glu His Pro Asn 100 105 110 Val Thr Leu Thr Ile Ser Ala Ala Arg Leu
Tyr Tyr Tyr Trp Glu Arg 115 120 125 Asp Tyr Arg Arg Ala Leu Cys Arg
Leu Ser Gln Ala Gly Ala Arg Val 130 135 140 Lys Ile Met Asp Asp Glu
Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 145 150 155 160 Tyr Ser Glu
Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 165 170 175 Tyr
Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 180 185
190 Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg
195 200 205 Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met
Glu Val 210 215 220 Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly
Val Phe Arg Asn 225 230 235 240 Gln Val Asp Pro Glu Thr His Cys His
Ala Glu Arg Cys Phe Leu Ser 245 250 255 Trp Phe Cys Asp Asp Ile Leu
Ser Pro Asn Thr Asn Tyr Glu Val Thr 260 265 270 Trp Tyr Thr Ser Trp
Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 275 280 285 Glu Phe Leu
Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 290 295 300 Arg
Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 305 310
315 320 Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp
Phe 325 330 335 Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu
Pro Phe Lys 340 345 350 Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe
Leu Asp Ser Lys Leu 355 360 365 Gln Glu Ile Leu Glu 370 <210>
SEQ ID NO 17 <211> LENGTH: 382 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 Met Asn
Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 1 5 10 15
Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 20
25 30 Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn
Leu 35 40 45 Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe
Lys Pro Gln 50 55 60 Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe
Cys Gly Asn Gln Leu 65 70 75 80 Pro Ala Tyr Lys Cys Phe Gln Ile Thr
Trp Phe Val Ser Trp Thr Pro 85 90 95 Cys Pro Asp Cys Val Ala Lys
Leu Ala Glu Phe Leu Ser Glu His Pro 100 105 110 Asn Val Thr Leu Thr
Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 115 120 125 Arg Asp Tyr
Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 130 135 140 Val
Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 145 150
155 160 Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp
Glu 165 170 175 Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu
Arg Tyr Leu 180 185 190 Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn
Asn Asp Pro Leu Val 195 200 205 Leu Arg Arg Arg Gln Thr Tyr Leu Cys
Tyr Glu Val Glu Arg Leu Asp 210 215 220 Asn Gly Thr Trp Val Leu Met
Asp Gln His Met Gly Phe Leu Cys Asn 225 230 235 240 Glu Ala Lys Asn
Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 245 250 255 Arg Phe
Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 260 265 270
Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 275
280 285 Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val
Arg 290 295 300 Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro
Leu Tyr Lys 305 310 315 320 Glu Ala Leu Gln Met Leu Arg Asp Ala Gly
Ala Gln Val Ser Ile Met 325 330 335 Thr Tyr Asp Glu Phe Glu Tyr Cys
Trp Asp Thr Phe Val Tyr Arg Gln 340 345 350 Gly Cys Pro Phe Gln Pro
Trp Asp Gly Leu Glu Glu His Ser Gln Ala 355 360 365 Leu Ser Gly Arg
Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 370 375 380 <210> SEQ
ID NO 18 <211> LENGTH: 190 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Asn Pro Gln Ile
Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 1 5 10 15 Phe Tyr Phe
Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 20 25 30 Thr
Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 35 40
45 Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His
50 55 60 Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp
Ile Leu 65 70 75 80 Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr
Ser Trp Ser Pro 85 90 95 Cys Pro Asp Cys Ala Gly Glu Val Ala Glu
Phe Leu Ala Arg His Ser 100 105 110 Asn Val Asn Leu Thr Ile Phe Thr
Ala Arg Leu Tyr Tyr Phe Gln Tyr 115 120 125 Pro Cys Tyr Gln Glu Gly
Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 130 135 140 Val Glu Ile Met
Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 145 150 155 160 Val
Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 165 170
175 Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 180 185
190 <210> SEQ ID NO 19 <211> LENGTH: 199 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
19 Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His
1 5 10 15 Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys
Thr Tyr 20 25 30
Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 35
40 45 Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu
Cys 50 55 60 Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp
Leu Val Pro 65 70 75 80 Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg
Val Thr Trp Phe Ile 85 90 95 Ser Trp Ser Pro Cys Phe Ser Trp Gly
Cys Ala Gly Glu Val Arg Ala 100 105 110 Phe Leu Gln Glu Asn Thr His
Val Arg Leu Arg Ile Phe Ala Ala Arg 115 120 125 Ile Tyr Asp Tyr Asp
Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 130 135 140 Asp Ala Gly
Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 145 150 155 160
Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 165
170 175 Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg
Ala 180 185 190 Ile Leu Gln Asn Gln Gly Asn 195 <210> SEQ ID
NO 20 <211> LENGTH: 200 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 20 Met Ala Leu Leu Thr
Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 1 5 10 15 Arg Arg Leu
Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 20 25 30 Gln
Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 35 40
45 Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys
50 55 60 Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys
Tyr Leu 65 70 75 80 Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu
Val Asp Phe Ile 85 90 95 Lys Ala His Asp His Leu Asn Leu Gly Ile
Phe Ala Ser Arg Leu Tyr 100 105 110 Tyr His Trp Cys Lys Pro Gln Gln
Lys Gly Leu Arg Leu Leu Cys Gly 115 120 125 Ser Gln Val Pro Val Glu
Val Met Gly Phe Pro Lys Phe Ala Asp Cys 130 135 140 Trp Glu Asn Phe
Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 145 150 155 160 Lys
Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 165 170
175 Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met
180 185 190 Asp Ile Leu Cys Asp Ala Glu Val 195 200 <210> SEQ
ID NO 21 <211> LENGTH: 386 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 21 Met Asn Pro Gln Ile
Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 1 5 10 15 Phe Tyr Asp
Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 20 25 30 Thr
Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 35 40
45 Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln
50 55 60 Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His
Ala Glu 65 70 75 80 Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu
Pro Ala Asn Arg 85 90 95 Arg Phe Gln Ile Thr Trp Phe Val Ser Trp
Asn Pro Cys Leu Pro Cys 100 105 110 Val Val Lys Val Thr Lys Phe Leu
Ala Glu His Pro Asn Val Thr Leu 115 120 125 Thr Ile Ser Ala Ala Arg
Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 130 135 140 Trp Val Leu Leu
Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 145 150 155 160 Asp
Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu 165 170
175 Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser
180 185 190 Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu
Ala Met 195 200 205 Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu
Leu Lys Ala Cys 210 215 220 Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr
Met Glu Val Thr Lys His 225 230 235 240 His Ser Ala Val Phe Arg Lys
Arg Gly Val Phe Arg Asn Gln Val Asp 245 250 255 Pro Glu Thr His Cys
His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 260 265 270 Asp Asp Ile
Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 275 280 285 Ser
Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 290 295
300 Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys
305 310 315 320 Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser
Leu Ser Gln 325 330 335 Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys
Asp Phe Val Ser Cys 340 345 350 Trp Lys Asn Phe Val Tyr Ser Asp Asp
Glu Pro Phe Lys Pro Trp Lys 355 360 365 Gly Leu Gln Thr Asn Phe Arg
Leu Leu Lys Arg Arg Leu Arg Glu Ile 370 375 380 Leu Gln 385
<210> SEQ ID NO 22 <211> LENGTH: 236 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 Met
Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 1 5 10
15 Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu
20 25 30 Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met
Ser Arg 35 40 45 Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn
His Val Glu Val 50 55 60 Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg
Asp Phe His Pro Ser Met 65 70 75 80 Ser Cys Ser Ile Thr Trp Phe Leu
Ser Trp Ser Pro Cys Trp Glu Cys 85 90 95 Ser Gln Ala Ile Arg Glu
Phe Leu Ser Arg His Pro Gly Val Thr Leu 100 105 110 Val Ile Tyr Val
Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 115 120 125 Gln Gly
Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 130 135 140
Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 145
150 155 160 Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp
Met Met 165 170 175 Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser
Leu Pro Pro Cys 180 185 190 Leu Lys Ile Ser Arg Arg Trp Gln Asn His
Leu Thr Phe Phe Arg Leu 195 200 205 His Leu Gln Asn Cys His Tyr Gln
Thr Ile Pro Pro His Ile Leu Leu 210 215 220 Ala Thr Gly Leu Ile His
Pro Ser Val Ala Trp Arg 225 230 235 <210> SEQ ID NO 23
<211> LENGTH: 229 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 23 Met Ser Ser Glu Thr Gly Pro
Val Ala Val Asp Pro Thr Leu Arg Arg 1 5 10 15 Arg Ile Glu Pro His
Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 20 25 30 Arg Lys Glu
Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 35 40 45 Ser
Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn His Val Glu Val 50 55
60 Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg Tyr Phe Arg Pro Asn Thr
65 70 75 80 Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly
Glu Cys 85 90 95 Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg His Pro
Tyr Val Thr Leu 100 105 110 Phe Ile Tyr Ile Ala Arg Leu Tyr His His
Thr Asp Gln Arg Asn Arg 115 120 125 Gln Gly Leu Arg Asp Leu Ile Ser
Ser Gly Val Thr Ile Gln Ile Met 130 135 140
Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 145
150 155 160 Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp
Val Lys 165 170 175 Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly
Leu Pro Pro Cys 180 185 190 Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln
Leu Thr Phe Phe Thr Ile 195 200 205 Thr Leu Gln Thr Cys His Tyr Gln
Arg Ile Pro Pro His Leu Leu Trp 210 215 220 Ala Thr Gly Leu Lys 225
<210> SEQ ID NO 24 <211> LENGTH: 229 <212> TYPE:
PRT <213> ORGANISM: Rattus norvegicus <400> SEQUENCE:
24 Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg
1 5 10 15 Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg
Glu Leu 20 25 30 Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp
Gly Gly Arg His 35 40 45 Ser Ile Trp Arg His Thr Ser Gln Asn Thr
Asn Lys His Val Glu Val 50 55 60 Asn Phe Ile Glu Lys Phe Thr Thr
Glu Arg Tyr Phe Cys Pro Asn Thr 65 70 75 80 Arg Cys Ser Ile Thr Trp
Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 85 90 95 Ser Arg Ala Ile
Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 100 105 110 Phe Ile
Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 115 120 125
Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 130
135 140 Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr
Ser 145 150 155 160 Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His
Leu Trp Val Arg 165 170 175 Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile
Leu Gly Leu Pro Pro Cys 180 185 190 Leu Asn Ile Leu Arg Arg Lys Gln
Pro Gln Leu Thr Phe Phe Thr Ile 195 200 205 Ala Leu Gln Ser Cys His
Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 210 215 220 Ala Thr Gly Leu
Lys 225 <210> SEQ ID NO 25 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 25 Met Glu Ala Lys Ala Ala Pro Lys Pro Ala
Ala Ser Gly Ala Cys Ser 1 5 10 15 Val Ser Ala Glu Glu Thr Glu Lys
Trp Met Glu Glu Ala Met His Met 20 25 30 Ala Lys Glu Ala Leu Glu
Asn Thr Glu Val Pro Val Gly Cys Leu Met 35 40 45 Val Tyr Asn Asn
Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn Gln 50 55 60 Thr Lys
Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val 65 70 75 80
Leu Asp Trp Cys Arg Gln Ser Gly Lys Ser Pro Ser Glu Val Phe Glu 85
90 95 His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala
Ala 100 105 110 Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly
Cys Gln Asn 115 120 125 Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn
Ile Ala Ser Ala Asp 130 135 140 Leu Pro Asn Thr Gly Arg Pro Phe Gln
Cys Ile Pro Gly Tyr Arg Ala 145 150 155 160 Glu Glu Ala Val Glu Met
Leu Lys Thr Phe Tyr Lys Gln Glu Asn Pro 165 170 175 Asn Ala Pro Lys
Ser Lys Val Arg Lys Lys Glu Cys Gln Lys Ser 180 185 190 <210>
SEQ ID NO 26 <211> LENGTH: 191 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 26 Met Glu
Glu Lys Val Glu Ser Thr Thr Thr Pro Asp Gly Pro Cys Val 1 5 10 15
Val Ser Val Gln Glu Thr Glu Lys Trp Met Glu Glu Ala Met Arg Met 20
25 30 Ala Lys Glu Ala Leu Glu Asn Ile Glu Val Pro Val Gly Cys Leu
Met 35 40 45 Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu
Val Asn Gln 50 55 60 Thr Lys Asn Ala Thr Arg His Ala Glu Met Val
Ala Ile Asp Gln Val 65 70 75 80 Leu Asp Trp Cys His Gln His Gly Gln
Ser Pro Ser Thr Val Phe Glu 85 90 95 His Thr Val Leu Tyr Val Thr
Val Glu Pro Cys Ile Met Cys Ala Ala 100 105 110 Ala Leu Arg Leu Met
Lys Ile Pro Leu Val Val Tyr Gly Cys Gln Asn 115 120 125 Glu Arg Phe
Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala Asp 130 135 140 Leu
Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg Ala 145 150
155 160 Glu Glu Ala Val Glu Leu Leu Lys Thr Phe Tyr Lys Gln Glu Asn
Pro 165 170 175 Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Asp Cys Gln
Lys Ser 180 185 190 <210> SEQ ID NO 27 <211> LENGTH:
499 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 27 Met Trp Thr Ala Asp Glu Ile Ala Gln Leu
Cys Tyr Ala His Tyr Asn 1 5 10 15 Val Arg Leu Pro Lys Gln Gly Lys
Pro Glu Pro Asn Arg Glu Trp Thr 20 25 30 Leu Leu Ala Ala Val Val
Lys Ile Gln Ala Ser Ala Asn Gln Ala Cys 35 40 45 Asp Ile Pro Glu
Lys Glu Val Gln Val Thr Lys Glu Val Val Ser Met 50 55 60 Gly Thr
Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Glu Ser Gly 65 70 75 80
Asp Ile Leu Asn Asp Ser His Ala Glu Ile Ile Ala Arg Arg Ser Phe 85
90 95 Gln Arg Tyr Leu Leu His Gln Leu His Leu Ala Ala Val Leu Lys
Glu 100 105 110 Asp Ser Ile Phe Val Pro Gly Thr Gln Arg Gly Leu Trp
Arg Leu Arg 115 120 125 Pro Asp Leu Ser Phe Val Phe Phe Ser Ser His
Thr Pro Cys Gly Asp 130 135 140 Ala Ser Ile Ile Pro Met Leu Glu Phe
Glu Glu Gln Pro Cys Cys Pro 145 150 155 160 Val Ile Arg Ser Trp Ala
Asn Asn Ser Pro Val Gln Glu Thr Glu Asn 165 170 175 Leu Glu Asp Ser
Lys Asp Lys Arg Asn Cys Glu Asp Pro Ala Ser Pro 180 185 190 Val Ala
Lys Lys Met Arg Leu Gly Thr Pro Ala Arg Ser Leu Ser Asn 195 200 205
Cys Val Ala His His Gly Thr Gln Glu Ser Gly Pro Val Lys Pro Asp 210
215 220 Val Ser Ser Ser Asp Leu Thr Lys Glu Glu Pro Asp Ala Ala Asn
Gly 225 230 235 240 Ile Ala Ser Gly Ser Phe Arg Val Val Asp Val Tyr
Arg Thr Gly Ala 245 250 255 Lys Cys Val Pro Gly Glu Thr Gly Asp Leu
Arg Glu Pro Gly Ala Ala 260 265 270 Tyr His Gln Val Gly Leu Leu Arg
Val Lys Pro Gly Arg Gly Asp Arg 275 280 285 Thr Cys Ser Met Ser Cys
Ser Asp Lys Met Ala Arg Trp Asn Val Leu 290 295 300 Gly Cys Gln Gly
Ala Leu Leu Met His Phe Leu Glu Lys Pro Ile Tyr 305 310 315 320 Leu
Ser Ala Val Val Ile Gly Lys Cys Pro Tyr Ser Gln Glu Ala Met 325 330
335 Arg Arg Ala Leu Thr Gly Arg Cys Glu Glu Thr Leu Val Leu Pro Arg
340 345 350 Gly Phe Gly Val Gln Glu Leu Glu Ile Gln Gln Ser Gly Leu
Leu Phe 355 360 365 Glu Gln Ser Arg Cys Ala Val His Arg Lys Arg Gly
Asp Ser Pro Gly 370 375 380 Arg Leu Val Pro Cys Gly Ala Ala Ile Ser
Trp Ser Ala Val Pro Gln 385 390 395 400 Gln Pro Leu Asp Val Thr Ala
Asn Gly Phe Pro Gln Gly Thr Thr Lys 405 410 415 Lys Glu Ile Gly Ser
Pro Arg Ala Arg Ser Arg Ile Ser Lys Val Glu 420 425 430 Leu Phe Arg
Ser Phe Gln Lys Leu Leu Ser Ser Ile Ala Asp Asp Glu 435 440 445
Gln Pro Asp Ser Ile Arg Val Thr Lys Lys Leu Asp Thr Tyr Gln Glu 450
455 460 Tyr Lys Asp Ala Ala Ser Ala Tyr Gln Glu Ala Trp Gly Ala Leu
Arg 465 470 475 480 Arg Ile Gln Pro Phe Ala Ser Trp Ile Arg Asn Pro
Pro Asp Tyr His 485 490 495 Gln Phe Lys <210> SEQ ID NO 28
<211> LENGTH: 502 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 28 Met Trp Thr Ala Asp Glu Ile
Ala Gln Leu Cys Tyr Glu His Tyr Gly 1 5 10 15 Ile Arg Leu Pro Lys
Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr 20 25 30 Leu Leu Ala
Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys 35 40 45 Asp
Thr Pro Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met 50 55
60 Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly
65 70 75 80 Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg
Ser Phe 85 90 95 Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala
Thr Leu Lys Glu 100 105 110 Asp Ser Ile Phe Val Pro Gly Thr Gln Lys
Gly Val Trp Lys Leu Arg 115 120 125 Arg Asp Leu Ile Phe Val Phe Phe
Ser Ser His Thr Pro Cys Gly Asp 130 135 140 Ala Ser Ile Ile Pro Met
Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro 145 150 155 160 Val Phe Arg
Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn 165 170 175 Leu
Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro 180 185
190 Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val
195 200 205 Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys
Ser Gly 210 215 220 Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr
Val Glu Gly Leu 225 230 235 240 Ala Thr Val Thr Arg Ile Ala Pro Gly
Ser Ala Lys Val Ile Asp Val 245 250 255 Tyr Arg Thr Gly Ala Lys Cys
Val Pro Gly Glu Ala Gly Asp Ser Gly 260 265 270 Lys Pro Gly Ala Ala
Phe His Gln Val Gly Leu Leu Arg Val Lys Pro 275 280 285 Gly Arg Gly
Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 290 295 300 Arg
Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu 305 310
315 320 Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro
Tyr 325 330 335 Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys
Gln Asn Val 340 345 350 Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu
Leu Lys Ile Leu Gln 355 360 365 Ser Asp Leu Leu Phe Glu Gln Ser Arg
Ser Ala Val Gln Ala Lys Arg 370 375 380 Ala Asp Ser Pro Gly Arg Leu
Val Pro Cys Gly Ala Ala Ile Ser Trp 385 390 395 400 Ser Ala Val Pro
Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro 405 410 415 Gln Gly
Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln 420 425 430
Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg 435
440 445 Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu
Asp 450 455 460 Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln
Glu Ala Trp 465 470 475 480 Ser Thr Leu Arg Lys Gln Val Phe Gly Ser
Trp Ile Arg Asn Pro Pro 485 490 495 Asp Tyr His Gln Phe Lys 500
<210> SEQ ID NO 29 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 29 Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 1 5 10
<210> SEQ ID NO 30 <211> LENGTH: 1580 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 30 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr
Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr
Tyr Leu Cys Asp Lys 20 25 30 Lys Tyr Ser Ile Gly Leu Ala Ile Gly
Thr Asn Ser Val Gly Trp Ala 35 40 45 Val Ile Thr Asp Glu Tyr Lys
Val Pro Ser Lys Lys Phe Lys Val Leu 50 55 60 Gly Asn Thr Asp Arg
His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 65 70 75 80 Leu Phe Asp
Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 85 90 95 Ala
Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 100 105
110 Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His
115 120 125 Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His
Glu Arg 130 135 140 His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala
Tyr His Glu Lys 145 150 155 160 Tyr Pro Thr Ile Tyr His Leu Arg Lys
Lys Leu Val Asp Ser Thr Asp 165 170 175 Lys Ala Asp Leu Arg Leu Ile
Tyr Leu Ala Leu Ala His Met Ile Lys 180 185 190 Phe Arg Gly His Phe
Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 195 200 205 Asp Val Asp
Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 210 215 220 Phe
Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 225 230
235 240 Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile
Ala 245 250 255 Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn
Leu Ile Ala 260 265 270 Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser
Asn Phe Asp Leu Ala 275 280 285 Glu Asp Ala Lys Leu Gln Leu Ser Lys
Asp Thr Tyr Asp Asp Asp Leu 290 295 300 Asp Asn Leu Leu Ala Gln Ile
Gly Asp Gln Tyr Ala Asp Leu Phe Leu 305 310 315 320 Ala Ala Lys Asn
Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 325 330 335 Val Asn
Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 340 345 350
Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 355
360 365 Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln
Ser 370 375 380 Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser
Gln Glu Glu 385 390 395 400 Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu
Lys Met Asp Gly Thr Glu 405 410 415 Glu Leu Leu Val Lys Leu Asn Arg
Glu Asp Leu Leu Arg Lys Gln Arg 420 425 430 Thr Phe Asp Asn Gly Ser
Ile Pro His Gln Ile His Leu Gly Glu Leu 435 440 445 His Ala Ile Leu
Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 450 455 460 Asn Arg
Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 465 470 475
480 Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg
485 490 495 Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val
Val Asp 500 505 510 Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met
Thr Asn Phe Asp 515 520 525 Lys Asn Leu Pro Asn Glu Lys Val Leu Pro
Lys His Ser Leu Leu Tyr 530 535 540 Glu Tyr Phe Thr Val Tyr Asn Glu
Leu Thr Lys Val Lys Tyr Val Thr 545 550 555 560 Glu Gly Met Arg Lys
Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 565 570 575 Ile Val Asp
Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 580 585 590 Leu
Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 595 600
605
Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His 610
615 620 Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu
Glu 625 630 635 640 Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu
Thr Leu Phe Glu 645 650 655 Asp Arg Glu Met Ile Glu Glu Arg Leu Lys
Thr Tyr Ala His Leu Phe 660 665 670 Asp Asp Lys Val Met Lys Gln Leu
Lys Arg Arg Arg Tyr Thr Gly Trp 675 680 685 Gly Arg Leu Ser Arg Lys
Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 690 695 700 Gly Lys Thr Ile
Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 705 710 715 720 Asn
Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 725 730
735 Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His
740 745 750 Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile
Leu Gln 755 760 765 Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met
Gly Arg His Lys 770 775 780 Pro Glu Asn Ile Val Ile Glu Met Ala Arg
Glu Asn Gln Thr Thr Gln 785 790 795 800 Lys Gly Gln Lys Asn Ser Arg
Glu Arg Met Lys Arg Ile Glu Glu Gly 805 810 815 Ile Lys Glu Leu Gly
Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 820 825 830 Thr Gln Leu
Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 835 840 845 Arg
Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 850 855
860 Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser
865 870 875 880 Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg
Gly Lys Ser 885 890 895 Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys
Met Lys Asn Tyr Trp 900 905 910 Arg Gln Leu Leu Asn Ala Lys Leu Ile
Thr Gln Arg Lys Phe Asp Asn 915 920 925 Leu Thr Lys Ala Glu Arg Gly
Gly Leu Ser Glu Leu Asp Lys Ala Gly 930 935 940 Phe Ile Lys Arg Gln
Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 945 950 955 960 Ala Gln
Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 965 970 975
Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val 980
985 990 Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile
Asn 995 1000 1005 Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala
Val Val Gly 1010 1015 1020 Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu
Glu Ser Glu Phe Val 1025 1030 1035 Tyr Gly Asp Tyr Lys Val Tyr Asp
Val Arg Lys Met Ile Ala Lys 1040 1045 1050 Ser Glu Gln Glu Ile Gly
Lys Ala Thr Ala Lys Tyr Phe Phe Tyr 1055 1060 1065 Ser Asn Ile Met
Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn 1070 1075 1080 Gly Glu
Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr 1085 1090 1095
Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 1100
1105 1110 Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr
Glu 1115 1120 1125 Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu
Pro Lys Arg 1130 1135 1140 Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys
Asp Trp Asp Pro Lys 1145 1150 1155 Lys Tyr Gly Gly Phe Asp Ser Pro
Thr Val Ala Tyr Ser Val Leu 1160 1165 1170 Val Val Ala Lys Val Glu
Lys Gly Lys Ser Lys Lys Leu Lys Ser 1175 1180 1185 Val Lys Glu Leu
Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe 1190 1195 1200 Glu Lys
Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 1205 1210 1215
Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 1220
1225 1230 Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly
Glu 1235 1240 1245 Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys
Tyr Val Asn 1250 1255 1260 Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys
Leu Lys Gly Ser Pro 1265 1270 1275 Glu Asp Asn Glu Gln Lys Gln Leu
Phe Val Glu Gln His Lys His 1280 1285 1290 Tyr Leu Asp Glu Ile Ile
Glu Gln Ile Ser Glu Phe Ser Lys Arg 1295 1300 1305 Val Ile Leu Ala
Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr 1310 1315 1320 Asn Lys
His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile 1325 1330 1335
Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe 1340
1345 1350 Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser
Thr 1355 1360 1365 Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser
Ile Thr Gly 1370 1375 1380 Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln
Leu Gly Gly Asp Gly 1385 1390 1395 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Tyr 1400 1405 1410 Val Val Lys Arg Arg Asp
Ser Ala Thr Ser Phe Ser Leu Asp Phe 1415 1420 1425 Gly Tyr Leu Arg
Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe 1430 1435 1440 Leu Arg
Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr 1445 1450 1455
Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala 1460
1465 1470 Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser
Leu 1475 1480 1485 Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp
Arg Lys Ala 1490 1495 1500 Glu Pro Glu Gly Leu Arg Arg Leu His Arg
Ala Gly Val Gln Ile 1505 1510 1515 Ala Ile Met Thr Phe Lys Asp Tyr
Phe Tyr Cys Trp Asn Thr Phe 1520 1525 1530 Val Glu Asn His Glu Arg
Thr Phe Lys Ala Trp Glu Gly Leu His 1535 1540 1545 Glu Asn Ser Val
Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu 1550 1555 1560 Pro Leu
Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu 1565 1570 1575
Gly Leu 1580 <210> SEQ ID NO 31 <211> LENGTH: 1564
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polypeptide <400> SEQUENCE: 31 Met Asp Ser Leu Leu Met Asn
Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala
Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg
Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 35 40 45 Leu
Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55
60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp
65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val
Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile
Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu
Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile
Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr
Phe Val Glu Asn His Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu
Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg
Arg Ile Leu Leu Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 180 185
190 Gly Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly
195 200 205 Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys
Val Pro 210 215 220 Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg
His Ser Ile Lys 225 230 235 240 Lys Asn Leu Ile Gly Ala Leu Leu Phe
Asp Ser Gly Glu Thr Ala Glu 245 250 255 Ala Thr Arg Leu Lys Arg Thr
Ala Arg Arg Arg Tyr Thr Arg Arg Lys
260 265 270 Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met
Ala Lys 275 280 285 Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser
Phe Leu Val Glu 290 295 300 Glu Asp Lys Lys His Glu Arg His Pro Ile
Phe Gly Asn Ile Val Asp 305 310 315 320 Glu Val Ala Tyr His Glu Lys
Tyr Pro Thr Ile Tyr His Leu Arg Lys 325 330 335 Lys Leu Val Asp Ser
Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 340 345 350 Ala Leu Ala
His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 355 360 365 Asp
Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 370 375
380 Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser
385 390 395 400 Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser
Lys Ser Arg 405 410 415 Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly
Glu Lys Lys Asn Gly 420 425 430 Leu Phe Gly Asn Leu Ile Ala Leu Ser
Leu Gly Leu Thr Pro Asn Phe 435 440 445 Lys Ser Asn Phe Asp Leu Ala
Glu Asp Ala Lys Leu Gln Leu Ser Lys 450 455 460 Asp Thr Tyr Asp Asp
Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 465 470 475 480 Gln Tyr
Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 485 490 495
Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 500
505 510 Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp
Leu 515 520 525 Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu
Lys Tyr Lys 530 535 540 Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr
Ala Gly Tyr Ile Asp 545 550 555 560 Gly Gly Ala Ser Gln Glu Glu Phe
Tyr Lys Phe Ile Lys Pro Ile Leu 565 570 575 Glu Lys Met Asp Gly Thr
Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 580 585 590 Asp Leu Leu Arg
Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 595 600 605 Gln Ile
His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 610 615 620
Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 625
630 635 640 Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly
Asn Ser 645 650 655 Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr
Ile Thr Pro Trp 660 665 670 Asn Phe Glu Glu Val Val Asp Lys Gly Ala
Ser Ala Gln Ser Phe Ile 675 680 685 Glu Arg Met Thr Asn Phe Asp Lys
Asn Leu Pro Asn Glu Lys Val Leu 690 695 700 Pro Lys His Ser Leu Leu
Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 705 710 715 720 Thr Lys Val
Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 725 730 735 Ser
Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 740 745
750 Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile
755 760 765 Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg
Phe Asn 770 775 780 Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile
Ile Lys Asp Lys 785 790 795 800 Asp Phe Leu Asp Asn Glu Glu Asn Glu
Asp Ile Leu Glu Asp Ile Val 805 810 815 Leu Thr Leu Thr Leu Phe Glu
Asp Arg Glu Met Ile Glu Glu Arg Leu 820 825 830 Lys Thr Tyr Ala His
Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 835 840 845 Arg Arg Arg
Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 850 855 860 Gly
Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 865 870
875 880 Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp
Asp 885 890 895 Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val
Ser Gly Gln 900 905 910 Gly Asp Ser Leu His Glu His Ile Ala Asn Leu
Ala Gly Ser Pro Ala 915 920 925 Ile Lys Lys Gly Ile Leu Gln Thr Val
Lys Val Val Asp Glu Leu Val 930 935 940 Lys Val Met Gly Arg His Lys
Pro Glu Asn Ile Val Ile Glu Met Ala 945 950 955 960 Arg Glu Asn Gln
Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 965 970 975 Met Lys
Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu 980 985 990
Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 995
1000 1005 Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln
Glu 1010 1015 1020 Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp
Ala Ile Val 1025 1030 1035 Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile
Asp Asn Lys Val Leu 1040 1045 1050 Thr Arg Ser Asp Lys Asn Arg Gly
Lys Ser Asp Asn Val Pro Ser 1055 1060 1065 Glu Glu Val Val Lys Lys
Met Lys Asn Tyr Trp Arg Gln Leu Leu 1070 1075 1080 Asn Ala Lys Leu
Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys 1085 1090 1095 Ala Glu
Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 1100 1105 1110
Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 1115
1120 1125 Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn
Asp 1130 1135 1140 Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys
Ser Lys Leu 1145 1150 1155 Val Ser Asp Phe Arg Lys Asp Phe Gln Phe
Tyr Lys Val Arg Glu 1160 1165 1170 Ile Asn Asn Tyr His His Ala His
Asp Ala Tyr Leu Asn Ala Val 1175 1180 1185 Val Gly Thr Ala Leu Ile
Lys Lys Tyr Pro Lys Leu Glu Ser Glu 1190 1195 1200 Phe Val Tyr Gly
Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile 1205 1210 1215 Ala Lys
Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe 1220 1225 1230
Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 1235
1240 1245 Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn
Gly 1250 1255 1260 Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp
Phe Ala Thr 1265 1270 1275 Val Arg Lys Val Leu Ser Met Pro Gln Val
Asn Ile Val Lys Lys 1280 1285 1290 Thr Glu Val Gln Thr Gly Gly Phe
Ser Lys Glu Ser Ile Leu Pro 1295 1300 1305 Lys Arg Asn Ser Asp Lys
Leu Ile Ala Arg Lys Lys Asp Trp Asp 1310 1315 1320 Pro Lys Lys Tyr
Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser 1325 1330 1335 Val Leu
Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 1340 1345 1350
Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser 1355
1360 1365 Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly
Tyr 1370 1375 1380 Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro
Lys Tyr Ser 1385 1390 1395 Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg
Met Leu Ala Ser Ala 1400 1405 1410 Gly Glu Leu Gln Lys Gly Asn Glu
Leu Ala Leu Pro Ser Lys Tyr 1415 1420 1425 Val Asn Phe Leu Tyr Leu
Ala Ser His Tyr Glu Lys Leu Lys Gly 1430 1435 1440 Ser Pro Glu Asp
Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His 1445 1450 1455 Lys His
Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser 1460 1465 1470
Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 1475
1480 1485 Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala
Glu 1490 1495 1500 Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly
Ala Pro Ala 1505 1510 1515 Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp
Arg Lys Arg Tyr Thr 1520 1525 1530 Ser Thr Lys Glu Val Leu Asp Ala
Thr Leu Ile His Gln Ser Ile 1535 1540 1545 Thr Gly Leu Tyr Glu Thr
Arg Ile Asp Leu Ser Gln Leu Gly Gly 1550 1555 1560
Asp <210> SEQ ID NO 32 <211> LENGTH: 1579 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 32 Met Asp Ser Leu Leu Met Asn Arg Arg Lys
Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg
Arg Glu Thr Tyr Leu Cys Asp Lys 20 25 30 Lys Tyr Ser Ile Gly Leu
Ala Ile Gly Thr Asn Ser Val Gly Trp Ala 35 40 45 Val Ile Thr Asp
Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu 50 55 60 Gly Asn
Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 65 70 75 80
Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 85
90 95 Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu
Gln 100 105 110 Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser
Phe Phe His 115 120 125 Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp
Lys Lys His Glu Arg 130 135 140 His Pro Ile Phe Gly Asn Ile Val Asp
Glu Val Ala Tyr His Glu Lys 145 150 155 160 Tyr Pro Thr Ile Tyr His
Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 165 170 175 Lys Ala Asp Leu
Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys 180 185 190 Phe Arg
Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 195 200 205
Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 210
215 220 Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala
Ile 225 230 235 240 Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu
Asn Leu Ile Ala 245 250 255 Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu
Phe Gly Asn Leu Ile Ala 260 265 270 Leu Ser Leu Gly Leu Thr Pro Asn
Phe Lys Ser Asn Phe Asp Leu Ala 275 280 285 Glu Asp Ala Lys Leu Gln
Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 290 295 300 Asp Asn Leu Leu
Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 305 310 315 320 Ala
Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 325 330
335 Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys
340 345 350 Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala
Leu Val 355 360 365 Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe
Phe Asp Gln Ser 370 375 380 Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly
Gly Ala Ser Gln Glu Glu 385 390 395 400 Phe Tyr Lys Phe Ile Lys Pro
Ile Leu Glu Lys Met Asp Gly Thr Glu 405 410 415 Glu Leu Leu Val Lys
Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 420 425 430 Thr Phe Asp
Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu 435 440 445 His
Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 450 455
460 Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr
465 470 475 480 Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp
Met Thr Arg 485 490 495 Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe
Glu Glu Val Val Asp 500 505 510 Lys Gly Ala Ser Ala Gln Ser Phe Ile
Glu Arg Met Thr Asn Phe Asp 515 520 525 Lys Asn Leu Pro Asn Glu Lys
Val Leu Pro Lys His Ser Leu Leu Tyr 530 535 540 Glu Tyr Phe Thr Val
Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 545 550 555 560 Glu Gly
Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 565 570 575
Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 580
585 590 Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val
Glu 595 600 605 Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly
Thr Tyr His 610 615 620 Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe
Leu Asp Asn Glu Glu 625 630 635 640 Asn Glu Asp Ile Leu Glu Asp Ile
Val Leu Thr Leu Thr Leu Phe Glu 645 650 655 Asp Arg Glu Met Ile Glu
Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 660 665 670 Asp Asp Lys Val
Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp 675 680 685 Gly Arg
Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 690 695 700
Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 705
710 715 720 Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys
Glu Asp 725 730 735 Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser
Leu His Glu His 740 745 750 Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile
Lys Lys Gly Ile Leu Gln 755 760 765 Thr Val Lys Val Val Asp Glu Leu
Val Lys Val Met Gly Arg His Lys 770 775 780 Pro Glu Asn Ile Val Ile
Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 785 790 795 800 Lys Gly Gln
Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 805 810 815 Ile
Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 820 825
830 Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly
835 840 845 Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu
Ser Asp 850 855 860 Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu
Lys Asp Asp Ser 865 870 875 880 Ile Asp Asn Lys Val Leu Thr Arg Ser
Asp Lys Asn Arg Gly Lys Ser 885 890 895 Asp Asn Val Pro Ser Glu Glu
Val Val Lys Lys Met Lys Asn Tyr Trp 900 905 910 Arg Gln Leu Leu Asn
Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 915 920 925 Leu Thr Lys
Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 930 935 940 Phe
Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 945 950
955 960 Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn
Asp 965 970 975 Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser
Lys Leu Val 980 985 990 Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys
Val Arg Glu Ile Asn 995 1000 1005 Asn Tyr His His Ala His Asp Ala
Tyr Leu Asn Ala Val Val Gly 1010 1015 1020 Thr Ala Leu Ile Lys Lys
Tyr Pro Lys Leu Glu Ser Glu Phe Val 1025 1030 1035 Tyr Gly Asp Tyr
Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1040 1045 1050 Ser Glu
Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr 1055 1060 1065
Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn 1070
1075 1080 Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu
Thr 1085 1090 1095 Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala
Thr Val Arg 1100 1105 1110 Lys Val Leu Ser Met Pro Gln Val Asn Ile
Val Lys Lys Thr Glu 1115 1120 1125 Val Gln Thr Gly Gly Phe Ser Lys
Glu Ser Ile Leu Pro Lys Arg 1130 1135 1140 Asn Ser Asp Lys Leu Ile
Ala Arg Lys Lys Asp Trp Asp Pro Lys 1145 1150 1155 Lys Tyr Gly Gly
Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu 1160 1165 1170 Val Val
Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 1175 1180 1185
Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe 1190
1195 1200 Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys
Glu 1205 1210 1215 Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr
Ser Leu Phe 1220 1225 1230 Glu Leu Glu Asn Gly Arg Lys Arg Met Leu
Ala Ser Ala Gly Glu 1235 1240 1245 Leu Gln Lys Gly Asn Glu Leu Ala
Leu Pro Ser Lys Tyr Val Asn 1250 1255 1260
Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 1265
1270 1275 Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys
His 1280 1285 1290 Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe
Ser Lys Arg 1295 1300 1305 Val Ile Leu Ala Asp Ala Asn Leu Asp Lys
Val Leu Ser Ala Tyr 1310 1315 1320 Asn Lys His Arg Asp Lys Pro Ile
Arg Glu Gln Ala Glu Asn Ile 1325 1330 1335 Ile His Leu Phe Thr Leu
Thr Asn Leu Gly Ala Pro Ala Ala Phe 1340 1345 1350 Lys Tyr Phe Asp
Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr 1355 1360 1365 Lys Glu
Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly 1370 1375 1380
Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly 1385
1390 1395 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Tyr 1400 1405 1410 Val Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser
Leu Asp Phe 1415 1420 1425 Gly His Leu Arg Asn Lys Ser Gly Cys His
Val Glu Leu Leu Phe 1430 1435 1440 Leu Arg Tyr Ile Ser Asp Trp Asp
Leu Asp Pro Gly Arg Cys Tyr 1445 1450 1455 Arg Val Thr Trp Phe Thr
Ser Trp Ser Pro Cys Tyr Asp Cys Ala 1460 1465 1470 Arg His Val Ala
Glu Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu 1475 1480 1485 Arg Ile
Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala 1490 1495 1500
Glu Pro Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile 1505
1510 1515 Gly Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr
Phe 1520 1525 1530 Val Glu Asn Arg Glu Arg Thr Phe Lys Ala Trp Glu
Gly Leu His 1535 1540 1545 Glu Asn Ser Val Arg Leu Thr Arg Gln Leu
Arg Arg Ile Leu Leu 1550 1555 1560 Pro Leu Tyr Glu Val Asp Asp Leu
Arg Asp Ala Phe Arg Met Leu 1565 1570 1575 Gly <210> SEQ ID
NO 33 <211> LENGTH: 1724 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 33
Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Leu Lys Tyr 1 5
10 15 His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys
Leu 20 25 30 His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser
Trp Ser Pro 35 40 45 Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe
Leu Ala Glu Asp Pro 50 55 60 Lys Val Thr Leu Thr Ile Phe Val Ala
Arg Leu Tyr Tyr Phe Trp Asp 65 70 75 80 Pro Asp Tyr Gln Glu Ala Leu
Arg Ser Leu Cys Gln Lys Arg Asp Gly 85 90 95 Pro Arg Ala Thr Met
Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 100 105 110 Trp Ser Lys
Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 115 120 125 Asn
Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 130 135
140 Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn
145 150 155 160 Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys
Tyr Glu Val 165 170 175 Glu Arg Met His Asn Asp Thr Trp Val Leu Leu
Asn Gln Arg Arg Gly 180 185 190 Phe Leu Cys Asn Gln Ala Pro His Lys
His Gly Phe Leu Glu Gly Arg 195 200 205 His Ala Glu Leu Cys Phe Leu
Asp Val Ile Pro Phe Trp Lys Leu Asp 210 215 220 Leu Asp Gln Asp Tyr
Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 225 230 235 240 Phe Ser
Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 245 250 255
Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 260
265 270 Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile
Ser 275 280 285 Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr
Phe Val Asp 290 295 300 His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly
Leu Asp Glu His Ser 305 310 315 320 Gln Asp Leu Ser Gly Arg Leu Arg
Ala Ile Leu Gln Asn Gln Glu Asn 325 330 335 Ser Pro Lys Lys Lys Arg
Lys Val Glu Ala Ser Ser Pro Lys Lys Lys 340 345 350 Arg Lys Val Glu
Ala Ser Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 355 360 365 Thr Asn
Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 370 375 380
Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 385
390 395 400 Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr
Ala Glu 405 410 415 Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr
Thr Arg Arg Lys 420 425 430 Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe
Ser Asn Glu Met Ala Lys 435 440 445 Val Asp Asp Ser Phe Phe His Arg
Leu Glu Glu Ser Phe Leu Val Glu 450 455 460 Glu Asp Lys Lys His Glu
Arg His Pro Ile Phe Gly Asn Ile Val Asp 465 470 475 480 Glu Val Ala
Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 485 490 495 Lys
Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 500 505
510 Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly
515 520 525 Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile
Gln Leu 530 535 540 Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro
Ile Asn Ala Ser 545 550 555 560 Gly Val Asp Ala Lys Ala Ile Leu Ser
Ala Arg Leu Ser Lys Ser Arg 565 570 575 Arg Leu Glu Asn Leu Ile Ala
Gln Leu Pro Gly Glu Lys Lys Asn Gly 580 585 590 Leu Phe Gly Asn Leu
Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 595 600 605 Lys Ser Asn
Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 610 615 620 Asp
Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 625 630
635 640 Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala
Ile 645 650 655 Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr
Lys Ala Pro 660 665 670 Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu
His His Gln Asp Leu 675 680 685 Thr Leu Leu Lys Ala Leu Val Arg Gln
Gln Leu Pro Glu Lys Tyr Lys 690 695 700 Glu Ile Phe Phe Asp Gln Ser
Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 705 710 715 720 Gly Gly Ala Ser
Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 725 730 735 Glu Lys
Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 740 745 750
Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 755
760 765 Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu
Asp 770 775 780 Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu
Lys Ile Leu 785 790 795 800 Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro
Leu Ala Arg Gly Asn Ser 805 810 815 Arg Phe Ala Trp Met Thr Arg Lys
Ser Glu Glu Thr Ile Thr Pro Trp 820 825 830 Asn Phe Glu Glu Val Val
Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 835 840 845 Glu Arg Met Thr
Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 850 855 860 Pro Lys
His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 865 870 875
880 Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu
885 890 895 Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys
Thr Asn 900 905 910 Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr
Phe Lys Lys Ile 915 920 925 Glu Cys Phe Asp Ser Val Glu Ile Ser Gly
Val Glu Asp Arg Phe Asn
930 935 940 Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys
Asp Lys 945 950 955 960 Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile
Leu Glu Asp Ile Val 965 970 975 Leu Thr Leu Thr Leu Phe Glu Asp Arg
Glu Met Ile Glu Glu Arg Leu 980 985 990 Lys Thr Tyr Ala His Leu Phe
Asp Asp Lys Val Met Lys Gln Leu Lys 995 1000 1005 Arg Arg Arg Tyr
Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile 1010 1015 1020 Asn Gly
Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 1025 1030 1035
Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 1040
1045 1050 His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala
Gln 1055 1060 1065 Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile
Ala Asn Leu 1070 1075 1080 Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile
Leu Gln Thr Val Lys 1085 1090 1095 Val Val Asp Glu Leu Val Lys Val
Met Gly Arg His Lys Pro Glu 1100 1105 1110 Asn Ile Val Ile Glu Met
Ala Arg Glu Asn Gln Thr Thr Gln Lys 1115 1120 1125 Gly Gln Lys Asn
Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 1130 1135 1140 Ile Lys
Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu 1145 1150 1155
Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 1160
1165 1170 Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn
Arg 1175 1180 1185 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln
Ser Phe Leu 1190 1195 1200 Lys Asp Asp Ser Ile Asp Asn Lys Val Leu
Thr Arg Ser Asp Lys 1205 1210 1215 Asn Arg Gly Lys Ser Asp Asn Val
Pro Ser Glu Glu Val Val Lys 1220 1225 1230 Lys Met Lys Asn Tyr Trp
Arg Gln Leu Leu Asn Ala Lys Leu Ile 1235 1240 1245 Thr Gln Arg Lys
Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 1250 1255 1260 Leu Ser
Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 1265 1270 1275
Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 1280
1285 1290 Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg
Glu 1295 1300 1305 Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser
Asp Phe Arg 1310 1315 1320 Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu
Ile Asn Asn Tyr His 1325 1330 1335 His Ala His Asp Ala Tyr Leu Asn
Ala Val Val Gly Thr Ala Leu 1340 1345 1350 Ile Lys Lys Tyr Pro Lys
Leu Glu Ser Glu Phe Val Tyr Gly Asp 1355 1360 1365 Tyr Lys Val Tyr
Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln 1370 1375 1380 Glu Ile
Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile 1385 1390 1395
Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile 1400
1405 1410 Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu
Ile 1415 1420 1425 Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg
Lys Val Leu 1430 1435 1440 Ser Met Pro Gln Val Asn Ile Val Lys Lys
Thr Glu Val Gln Thr 1445 1450 1455 Gly Gly Phe Ser Lys Glu Ser Ile
Leu Pro Lys Arg Asn Ser Asp 1460 1465 1470 Lys Leu Ile Ala Arg Lys
Lys Asp Trp Asp Pro Lys Lys Tyr Gly 1475 1480 1485 Gly Phe Asp Ser
Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala 1490 1495 1500 Lys Val
Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu 1505 1510 1515
Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn 1520
1525 1530 Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys
Lys 1535 1540 1545 Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe
Glu Leu Glu 1550 1555 1560 Asn Gly Arg Lys Arg Met Leu Ala Ser Ala
Gly Glu Leu Gln Lys 1565 1570 1575 Gly Asn Glu Leu Ala Leu Pro Ser
Lys Tyr Val Asn Phe Leu Tyr 1580 1585 1590 Leu Ala Ser His Tyr Glu
Lys Leu Lys Gly Ser Pro Glu Asp Asn 1595 1600 1605 Glu Gln Lys Gln
Leu Phe Val Glu Gln His Lys His Tyr Leu Asp 1610 1615 1620 Glu Ile
Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu 1625 1630 1635
Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 1640
1645 1650 Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His
Leu 1655 1660 1665 Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe
Lys Tyr Phe 1670 1675 1680 Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr
Ser Thr Lys Glu Val 1685 1690 1695 Leu Asp Ala Thr Leu Ile His Gln
Ser Ile Thr Gly Leu Tyr Glu 1700 1705 1710 Thr Arg Ile Asp Leu Ser
Gln Leu Gly Gly Asp 1715 1720 <210> SEQ ID NO 34 <211>
LENGTH: 1368 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 34 Met Asp Lys Lys Tyr
Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala
Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys
Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40
45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu
50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg
Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys
Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu
Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly
Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr
Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys
Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met
Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170
175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr
180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val
Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg
Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys
Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly
Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp
Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu
Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu
Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295
300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser
305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr
Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr
Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly
Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe
Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu
Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln
Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415
Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420
425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg
Ile 435 440 445
Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450
455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu
Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile
Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys
Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val
Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met
Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile
Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val
Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570
575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly
580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe
Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val
Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu
Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val
Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg
Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser
Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala
Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695
700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu
705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile
Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu
Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile
Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys
Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys
Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu
Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815
Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820
825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu
Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp
Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val
Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn
Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys
Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe
Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His
Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940
Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945
950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys
Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr
Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro
Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val
Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu
Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn
Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn
Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060
1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val
1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys
Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser
Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg
Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp
Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys
Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys
Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe
Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180
1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu
1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser
Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro
Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr
Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys
Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu
Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile
Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr
Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300
1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala
1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr
Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His
Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu
Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210> SEQ ID NO 35
<211> LENGTH: 1851 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 35
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5
10 15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Ser
Met 20 25 30 Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg
Lys Asn Gly 35 40 45 Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile
Ala Arg Arg Ser Phe 50 55 60 Gln Arg Tyr Leu Leu His Gln Leu Gln
Leu Ala Ala Thr Leu Lys Glu 65 70 75 80 Asp Ser Ile Phe Val Pro Gly
Thr Gln Lys Gly Val Trp Lys Leu Arg 85 90 95 Arg Asp Leu Ile Phe
Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp 100 105 110 Ala Ser Ile
Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro 115 120 125 Val
Phe Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn 130 135
140 Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro
145 150 155 160 Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala
Arg Glu Val 165 170 175 Thr Asn Gly Ala Ala His His Gln Ser Phe Gly
Lys Gln Lys Ser Gly 180 185 190 Pro Ile Ser Pro Gly Ile His Ser Cys
Asp Leu Thr Val Glu Gly Leu 195 200 205 Ala Thr Val Thr Arg Ile Ala
Pro Gly Ser Ala Lys Val Ile Asp Val 210 215 220 Tyr Arg Thr Gly Ala
Lys Cys Val Pro Gly Glu Ala Gly Asp Ser Gly 225 230 235 240 Lys Pro
Gly Ala Ala Phe His Gln Val Gly Leu Leu Arg Val Lys Pro 245 250 255
Gly Arg Gly Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 260
265 270 Arg Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu
Leu 275 280 285 Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys
Cys Pro Tyr 290 295 300 Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly
Arg Cys Gln Asn Val 305 310 315 320 Ser Ala Leu Pro Lys Gly Phe Gly
Val Gln Glu Leu Lys Ile Leu Gln 325 330 335
Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala Lys Arg 340
345 350 Ala Asp Ser Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile Ser
Trp 355 360 365 Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn
Gly Phe Pro 370 375 380 Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu
Gln Ala Arg Ser Gln 385 390 395 400 Ile Ser Lys Val Glu Leu Phe Arg
Ser Phe Gln Lys Leu Leu Ser Arg 405 410 415 Ile Ala Arg Asp Lys Trp
Pro His Ser Leu Arg Val Gln Lys Leu Asp 420 425 430 Thr Tyr Gln Glu
Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala Trp 435 440 445 Ser Thr
Leu Arg Lys Gln Val Phe Gly Ser Trp Ile Arg Asn Pro Pro 450 455 460
Asp Tyr His Gln Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 465
470 475 480 Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile
Gly Thr 485 490 495 Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr
Lys Val Pro Ser 500 505 510 Lys Lys Phe Lys Val Leu Gly Asn Thr Asp
Arg His Ser Ile Lys Lys 515 520 525 Asn Leu Ile Gly Ala Leu Leu Phe
Asp Ser Gly Glu Thr Ala Glu Ala 530 535 540 Thr Arg Leu Lys Arg Thr
Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 545 550 555 560 Arg Ile Cys
Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 565 570 575 Asp
Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 580 585
590 Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu
595 600 605 Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg
Lys Lys 610 615 620 Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu
Ile Tyr Leu Ala 625 630 635 640 Leu Ala His Met Ile Lys Phe Arg Gly
His Phe Leu Ile Glu Gly Asp 645 650 655 Leu Asn Pro Asp Asn Ser Asp
Val Asp Lys Leu Phe Ile Gln Leu Val 660 665 670 Gln Thr Tyr Asn Gln
Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 675 680 685 Val Asp Ala
Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 690 695 700 Leu
Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 705 710
715 720 Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe
Lys 725 730 735 Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu
Ser Lys Asp 740 745 750 Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala
Gln Ile Gly Asp Gln 755 760 765 Tyr Ala Asp Leu Phe Leu Ala Ala Lys
Asn Leu Ser Asp Ala Ile Leu 770 775 780 Leu Ser Asp Ile Leu Arg Val
Asn Thr Glu Ile Thr Lys Ala Pro Leu 785 790 795 800 Ser Ala Ser Met
Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 805 810 815 Leu Leu
Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 820 825 830
Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 835
840 845 Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu
Glu 850 855 860 Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn
Arg Glu Asp 865 870 875 880 Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn
Gly Ser Ile Pro His Gln 885 890 895 Ile His Leu Gly Glu Leu His Ala
Ile Leu Arg Arg Gln Glu Asp Phe 900 905 910 Tyr Pro Phe Leu Lys Asp
Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 915 920 925 Phe Arg Ile Pro
Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 930 935 940 Phe Ala
Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 945 950 955
960 Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu
965 970 975 Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val
Leu Pro 980 985 990 Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr
Asn Glu Leu Thr 995 1000 1005 Lys Val Lys Tyr Val Thr Glu Gly Met
Arg Lys Pro Ala Phe Leu 1010 1015 1020 Ser Gly Glu Gln Lys Lys Ala
Ile Val Asp Leu Leu Phe Lys Thr 1025 1030 1035 Asn Arg Lys Val Thr
Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 1040 1045 1050 Lys Ile Glu
Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 1055 1060 1065 Arg
Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 1070 1075
1080 Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile
1085 1090 1095 Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp
Arg Glu 1100 1105 1110 Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His
Leu Phe Asp Asp 1115 1120 1125 Lys Val Met Lys Gln Leu Lys Arg Arg
Arg Tyr Thr Gly Trp Gly 1130 1135 1140 Arg Leu Ser Arg Lys Leu Ile
Asn Gly Ile Arg Asp Lys Gln Ser 1145 1150 1155 Gly Lys Thr Ile Leu
Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn 1160 1165 1170 Arg Asn Phe
Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 1175 1180 1185 Glu
Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 1190 1195
1200 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys
1205 1210 1215 Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val
Lys Val 1220 1225 1230 Met Gly Arg His Lys Pro Glu Asn Ile Val Ile
Glu Met Ala Arg 1235 1240 1245 Glu Asn Gln Thr Thr Gln Lys Gly Gln
Lys Asn Ser Arg Glu Arg 1250 1255 1260 Met Lys Arg Ile Glu Glu Gly
Ile Lys Glu Leu Gly Ser Gln Ile 1265 1270 1275 Leu Lys Glu His Pro
Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 1280 1285 1290 Leu Tyr Leu
Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 1295 1300 1305 Gln
Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala 1310 1315
1320 Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys
1325 1330 1335 Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp
Asn Val 1340 1345 1350 Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn
Tyr Trp Arg Gln 1355 1360 1365 Leu Leu Asn Ala Lys Leu Ile Thr Gln
Arg Lys Phe Asp Asn Leu 1370 1375 1380 Thr Lys Ala Glu Arg Gly Gly
Leu Ser Glu Leu Asp Lys Ala Gly 1385 1390 1395 Phe Ile Lys Arg Gln
Leu Val Glu Thr Arg Gln Ile Thr Lys His 1400 1405 1410 Val Ala Gln
Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 1415 1420 1425 Asn
Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 1430 1435
1440 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val
1445 1450 1455 Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr
Leu Asn 1460 1465 1470 Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr
Pro Lys Leu Glu 1475 1480 1485 Ser Glu Phe Val Tyr Gly Asp Tyr Lys
Val Tyr Asp Val Arg Lys 1490 1495 1500 Met Ile Ala Lys Ser Glu Gln
Glu Ile Gly Lys Ala Thr Ala Lys 1505 1510 1515 Tyr Phe Phe Tyr Ser
Asn Ile Met Asn Phe Phe Lys Thr Glu Ile 1520 1525 1530 Thr Leu Ala
Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr 1535 1540 1545 Asn
Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe 1550 1555
1560 Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val
1565 1570 1575 Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu
Ser Ile 1580 1585 1590 Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala
Arg Lys Lys Asp 1595 1600 1605 Trp Asp Pro Lys Lys Tyr Gly Gly Phe
Asp Ser Pro Thr Val Ala 1610 1615 1620 Tyr Ser Val Leu Val Val Ala
Lys Val Glu Lys Gly Lys Ser Lys 1625 1630 1635
Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu 1640
1645 1650 Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala
Lys 1655 1660 1665 Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys
Leu Pro Lys 1670 1675 1680 Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg
Lys Arg Met Leu Ala 1685 1690 1695 Ser Ala Gly Glu Leu Gln Lys Gly
Asn Glu Leu Ala Leu Pro Ser 1700 1705 1710 Lys Tyr Val Asn Phe Leu
Tyr Leu Ala Ser His Tyr Glu Lys Leu 1715 1720 1725 Lys Gly Ser Pro
Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu 1730 1735 1740 Gln His
Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu 1745 1750 1755
Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val 1760
1765 1770 Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu
Gln 1775 1780 1785 Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn
Leu Gly Ala 1790 1795 1800 Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr
Ile Asp Arg Lys Arg 1805 1810 1815 Tyr Thr Ser Thr Lys Glu Val Leu
Asp Ala Thr Leu Ile His Gln 1820 1825 1830 Ser Ile Thr Gly Leu Tyr
Glu Thr Arg Ile Asp Leu Ser Gln Leu 1835 1840 1845 Gly Gly Asp 1850
<210> SEQ ID NO 36 <211> LENGTH: 1846 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 36 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr
Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr
Tyr Leu Cys Asp Lys 20 25 30 Lys Tyr Ser Ile Gly Leu Ala Ile Gly
Thr Asn Ser Val Gly Trp Ala 35 40 45 Val Ile Thr Asp Glu Tyr Lys
Val Pro Ser Lys Lys Phe Lys Val Leu 50 55 60 Gly Asn Thr Asp Arg
His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 65 70 75 80 Leu Phe Asp
Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 85 90 95 Ala
Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 100 105
110 Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His
115 120 125 Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His
Glu Arg 130 135 140 His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala
Tyr His Glu Lys 145 150 155 160 Tyr Pro Thr Ile Tyr His Leu Arg Lys
Lys Leu Val Asp Ser Thr Asp 165 170 175 Lys Ala Asp Leu Arg Leu Ile
Tyr Leu Ala Leu Ala His Met Ile Lys 180 185 190 Phe Arg Gly His Phe
Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 195 200 205 Asp Val Asp
Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 210 215 220 Phe
Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 225 230
235 240 Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile
Ala 245 250 255 Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn
Leu Ile Ala 260 265 270 Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser
Asn Phe Asp Leu Ala 275 280 285 Glu Asp Ala Lys Leu Gln Leu Ser Lys
Asp Thr Tyr Asp Asp Asp Leu 290 295 300 Asp Asn Leu Leu Ala Gln Ile
Gly Asp Gln Tyr Ala Asp Leu Phe Leu 305 310 315 320 Ala Ala Lys Asn
Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 325 330 335 Val Asn
Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 340 345 350
Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 355
360 365 Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln
Ser 370 375 380 Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser
Gln Glu Glu 385 390 395 400 Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu
Lys Met Asp Gly Thr Glu 405 410 415 Glu Leu Leu Val Lys Leu Asn Arg
Glu Asp Leu Leu Arg Lys Gln Arg 420 425 430 Thr Phe Asp Asn Gly Ser
Ile Pro His Gln Ile His Leu Gly Glu Leu 435 440 445 His Ala Ile Leu
Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 450 455 460 Asn Arg
Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 465 470 475
480 Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg
485 490 495 Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val
Val Asp 500 505 510 Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met
Thr Asn Phe Asp 515 520 525 Lys Asn Leu Pro Asn Glu Lys Val Leu Pro
Lys His Ser Leu Leu Tyr 530 535 540 Glu Tyr Phe Thr Val Tyr Asn Glu
Leu Thr Lys Val Lys Tyr Val Thr 545 550 555 560 Glu Gly Met Arg Lys
Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 565 570 575 Ile Val Asp
Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 580 585 590 Leu
Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 595 600
605 Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His
610 615 620 Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn
Glu Glu 625 630 635 640 Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr
Leu Thr Leu Phe Glu 645 650 655 Asp Arg Glu Met Ile Glu Glu Arg Leu
Lys Thr Tyr Ala His Leu Phe 660 665 670 Asp Asp Lys Val Met Lys Gln
Leu Lys Arg Arg Arg Tyr Thr Gly Trp 675 680 685 Gly Arg Leu Ser Arg
Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 690 695 700 Gly Lys Thr
Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 705 710 715 720
Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 725
730 735 Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu
His 740 745 750 Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly
Ile Leu Gln 755 760 765 Thr Val Lys Val Val Asp Glu Leu Val Lys Val
Met Gly Arg His Lys 770 775 780 Pro Glu Asn Ile Val Ile Glu Met Ala
Arg Glu Asn Gln Thr Thr Gln 785 790 795 800 Lys Gly Gln Lys Asn Ser
Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 805 810 815 Ile Lys Glu Leu
Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 820 825 830 Thr Gln
Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 835 840 845
Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 850
855 860 Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp
Ser 865 870 875 880 Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn
Arg Gly Lys Ser 885 890 895 Asp Asn Val Pro Ser Glu Glu Val Val Lys
Lys Met Lys Asn Tyr Trp 900 905 910 Arg Gln Leu Leu Asn Ala Lys Leu
Ile Thr Gln Arg Lys Phe Asp Asn 915 920 925 Leu Thr Lys Ala Glu Arg
Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 930 935 940 Phe Ile Lys Arg
Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 945 950 955 960 Ala
Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 965 970
975 Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val
980 985 990 Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu
Ile Asn 995 1000 1005 Asn Tyr His His Ala His Asp Ala Tyr Leu Asn
Ala Val Val Gly 1010 1015 1020 Thr Ala Leu Ile Lys Lys Tyr Pro Lys
Leu Glu Ser Glu Phe Val 1025 1030 1035
Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1040
1045 1050 Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe
Tyr 1055 1060 1065 Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr
Leu Ala Asn 1070 1075 1080 Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu
Thr Asn Gly Glu Thr 1085 1090 1095 Gly Glu Ile Val Trp Asp Lys Gly
Arg Asp Phe Ala Thr Val Arg 1100 1105 1110 Lys Val Leu Ser Met Pro
Gln Val Asn Ile Val Lys Lys Thr Glu 1115 1120 1125 Val Gln Thr Gly
Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg 1130 1135 1140 Asn Ser
Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys 1145 1150 1155
Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu 1160
1165 1170 Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys
Ser 1175 1180 1185 Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg
Ser Ser Phe 1190 1195 1200 Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala
Lys Gly Tyr Lys Glu 1205 1210 1215 Val Lys Lys Asp Leu Ile Ile Lys
Leu Pro Lys Tyr Ser Leu Phe 1220 1225 1230 Glu Leu Glu Asn Gly Arg
Lys Arg Met Leu Ala Ser Ala Gly Glu 1235 1240 1245 Leu Gln Lys Gly
Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn 1250 1255 1260 Phe Leu
Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 1265 1270 1275
Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His 1280
1285 1290 Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys
Arg 1295 1300 1305 Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu
Ser Ala Tyr 1310 1315 1320 Asn Lys His Arg Asp Lys Pro Ile Arg Glu
Gln Ala Glu Asn Ile 1325 1330 1335 Ile His Leu Phe Thr Leu Thr Asn
Leu Gly Ala Pro Ala Ala Phe 1340 1345 1350 Lys Tyr Phe Asp Thr Thr
Ile Asp Arg Lys Arg Tyr Thr Ser Thr 1355 1360 1365 Lys Glu Val Leu
Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly 1370 1375 1380 Leu Tyr
Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly 1385 1390 1395
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Met Gly Thr Gly Thr 1400
1405 1410 Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly Asp Ile
Leu 1415 1420 1425 Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser
Phe Gln Arg 1430 1435 1440 Tyr Leu Leu His Gln Leu Gln Leu Ala Ala
Thr Leu Lys Glu Asp 1445 1450 1455 Ser Ile Phe Val Pro Gly Thr Gln
Lys Gly Val Trp Lys Leu Arg 1460 1465 1470 Arg Asp Leu Ile Phe Val
Phe Phe Ser Ser His Thr Pro Cys Gly 1475 1480 1485 Asp Ala Ser Ile
Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys 1490 1495 1500 Cys Pro
Val Phe Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala 1505 1510 1515
Ser Ser Asn Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp 1520
1525 1530 Pro Asp Ser Pro Val Thr Lys Lys Met Arg Leu Glu Pro Gly
Thr 1535 1540 1545 Ala Ala Arg Glu Val Thr Asn Gly Ala Ala His His
Gln Ser Phe 1550 1555 1560 Gly Lys Gln Lys Ser Gly Pro Ile Ser Pro
Gly Ile His Ser Cys 1565 1570 1575 Asp Leu Thr Val Glu Gly Leu Ala
Thr Val Thr Arg Ile Ala Pro 1580 1585 1590 Gly Ser Ala Lys Val Ile
Asp Val Tyr Arg Thr Gly Ala Lys Cys 1595 1600 1605 Val Pro Gly Glu
Ala Gly Asp Ser Gly Lys Pro Gly Ala Ala Phe 1610 1615 1620 His Gln
Val Gly Leu Leu Arg Val Lys Pro Gly Arg Gly Asp Arg 1625 1630 1635
Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala Arg Trp Asn Val 1640
1645 1650 Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu Glu Glu
Pro 1655 1660 1665 Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro
Tyr Ser Gln 1670 1675 1680 Glu Ala Met Gln Arg Ala Leu Ile Gly Arg
Cys Gln Asn Val Ser 1685 1690 1695 Ala Leu Pro Lys Gly Phe Gly Val
Gln Glu Leu Lys Ile Leu Gln 1700 1705 1710 Ser Asp Leu Leu Phe Glu
Gln Ser Arg Ser Ala Val Gln Ala Lys 1715 1720 1725 Arg Ala Asp Ser
Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile 1730 1735 1740 Ser Trp
Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn 1745 1750 1755
Gly Phe Pro Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln 1760
1765 1770 Ala Arg Ser Gln Ile Ser Lys Val Glu Leu Phe Arg Ser Phe
Gln 1775 1780 1785 Lys Leu Leu Ser Arg Ile Ala Arg Asp Lys Trp Pro
His Ser Leu 1790 1795 1800 Arg Val Gln Lys Leu Asp Thr Tyr Gln Glu
Tyr Lys Glu Ala Ala 1805 1810 1815 Ser Ser Tyr Gln Glu Ala Trp Ser
Thr Leu Arg Lys Gln Val Phe 1820 1825 1830 Gly Ser Trp Ile Arg Asn
Pro Pro Asp Tyr His Gln Phe 1835 1840 1845 <210> SEQ ID NO 37
<211> LENGTH: 1368 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 37
Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5
10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys
Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys
Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala
Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr
Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser
Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu
Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg
His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His
Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135
140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp
Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln
Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile
Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg
Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu
Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile
Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255
Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260
265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala
Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu
Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala
Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His
His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln
Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys
Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu
Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380
Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385
390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile
His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp
Phe Tyr Pro Phe
420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe
Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser
Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr
Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser
Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn
Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr
Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr
Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535
540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr
545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu
Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe
Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile
Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile
Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg
Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu
Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655
Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660
665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly
Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser
Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly
Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala
Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys
Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro
Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr
Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780
Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785
790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr
Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu
Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val
Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val
Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val
Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp
Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe
Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905
910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr
915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys
Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile
Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp
Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His
Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu
Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr
Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020
Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025
1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu
Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr
Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg
Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln
Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly
Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp
Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys
Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140
Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145
1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser
Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys
Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu
Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys
Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn
Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr
Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu
Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260
His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265
1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser
Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln
Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu
Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile
Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp
Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu
Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365
<210> SEQ ID NO 38 <211> LENGTH: 82 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 38 guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu ccguuaucaa
cuugaaaaag 60 uggcaccgag ucggugcuuu uu 82 <210> SEQ ID NO 39
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 39
gatgacattg catacattcg aaagacccta gccttagata aaactgagca agaggctttg
60 gagtatttca tgaaacaaat gaatgatgca cgtcatggtg gctggacaac
aaaaatggat 120 tggatcttcc acacaattaa acagcatgca ttgaactgaa
agataactga gaaaatgaaa 180 <210> SEQ ID NO 40 <211>
LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 40 Asp Asp Ile Ala Tyr
Ile Arg Lys Thr Leu Ala Leu Asp Lys Thr Glu 1 5 10 15 Gln Glu Ala
Leu Glu Tyr Phe Met Lys Gln Met Asn Asp Ala Arg His 20 25 30 Gly
Gly Trp Thr Thr Lys Met Asp Trp Ile Phe His Thr Ile Lys Gln 35 40
45 His Ala Leu Asn Lys Ile Thr Glu Lys Met Lys 50 55 <210>
SEQ ID NO 41 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 41 aucggaauct auuuugacuc 20 <210> SEQ ID NO 42
<211> LENGTH: 20 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 42 ucggaaucua uuuugacucg 20 <210> SEQ ID NO 43
<211> LENGTH: 20 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 43
cuuagauaaa acugagcaag 20 <210> SEQ ID NO 44 <211>
LENGTH: 20 <212> TYPE: RNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 44 aucuauuuug
acucguucuc 20 <210> SEQ ID NO 45 <211> LENGTH: 20
<212> TYPE: RNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 45 uaaaacugag caagaggcuu 20
<210> SEQ ID NO 46 <211> LENGTH: 20 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 46 ugguggcugg acaacaaaaa 20 <210> SEQ ID NO 47
<211> LENGTH: 20 <212> TYPE: RNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 47
gcuggacaac aaaaauggau 20 <210> SEQ ID NO 48 <211>
LENGTH: 20 <212> TYPE: RNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 48 guguuaauuu
gucguacgua 20 <210> SEQ ID NO 49 <211> LENGTH: 180
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 49 aatcacattt ttccacttct
tgaaaagtac tgtggcttcc atgaagataa cattccccag 60 ctggaagacg
tttctcaatt cctgcagact tgcactggtc tccgcctccg acctgtggct 120
ggcctgcttt cctctcggga tttcttgggt ggcctggcct tccgagtctt ccactgcaca
180 <210> SEQ ID NO 50 <211> LENGTH: 60 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 50 Asn His Ile Phe Pro Leu Leu Glu Lys Tyr
Cys Gly Phe His Glu Asp 1 5 10 15 Asn Ile Pro Gln Leu Glu Asp Val
Ser Gln Phe Leu Gln Thr Cys Thr 20 25 30 Gly Ser Arg Leu Arg Pro
Val Ala Gly Leu Leu Ser Ser Arg Asp Phe 35 40 45 Leu Gly Gly Leu
Ala Phe Arg Val Phe His Cys Thr 50 55 60 <210> SEQ ID NO 51
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 51
atgcctgcct ggggagccct gttcctgctc tgggccacag cagaggccac caaggactgc
60 cccagcccac gtacctgccg cgccctggaa accatggggc tgtgggtgga
ctgcaggggc 120 cacggactca cggccctgcc tgccctgccg gcccgcaccc
gccaccttct gctggccaac 180 <210> SEQ ID NO 52 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 52 Met Pro Ala Trp Gly
Ala Leu Phe Leu Leu Trp Ala Thr Ala Glu Ala 1 5 10 15 Thr Lys Asp
Cys Pro Ser Pro Arg Thr Cys Arg Ala Leu Glu Thr Met 20 25 30 Gly
Leu Trp Val Asp Cys Arg Gly His Gly Leu Thr Ala Leu Pro Ala 35 40
45 Leu Pro Ala Arg Thr Arg His Leu Leu Leu Ala Asn 50 55 60
<210> SEQ ID NO 53 <211> LENGTH: 120 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 53 ggttatggtc ctgtctgccc tcctggtggc atacaagaag tcactatcaa
ccagagccct 60 cttcagcccc tcaatgtgga gattgaccct gagatccaaa
aggtgaagtc tcgagaaagg 120 <210> SEQ ID NO 54 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 54 Gly Tyr Gly Pro Val
Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile 1 5 10 15 Asn Gln Ser
Pro Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Glu Ile 20 25 30 Gln
Lys Val Lys Ser Arg Glu Arg 35 40 <210> SEQ ID NO 55
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 55
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat
60 gatcaggatc acccaacctt caacaagatc acccccaacc cggctgagtt
cgccttcagc 120 ctataccgcc agctggcaca ccagtccaac agcaccaata
tcttcttctc cccagtgagc 180 <210> SEQ ID NO 56 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 56 Val Ser Leu Ala Glu
Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp 1 5 10 15 Thr Ser His
His Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro 20 25 30 Asn
Pro Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln 35 40
45 Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 50 55 60
<210> SEQ ID NO 57 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 57 ggccactgcc tcattatcaa caatgtgaac ttctgccgtg agtccgggct
ccgcacccgc 60 actggctcca acatcgactg tgagaagttg cggcgtcgct
tctcctcgcc gcatttcatg 120 gtggaggtga agggcgacct gactgccaag
aaaatggtgc tggctttgct ggagctggcg 180 <210> SEQ ID NO 58
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 58 Gly His
Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 1 5 10
15
Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 20
25 30 Arg Phe Ser Ser Pro His Phe Met Val Glu Val Lys Gly Asp Leu
Thr 35 40 45 Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala 50 55
60 <210> SEQ ID NO 59 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 59 actagagcta gatactttct agttgggagc
aataatgcag aaacgaaata tcgtgtcttg 60 aagactgata gaacagaacc
aaaagatttg gtcataattg atgacaggca tgtctatact 120 caacaagaag
taagggaact tcttggccgc ttggatcttg gaaatagaac aaagatggga 180
<210> SEQ ID NO 60 <211> LENGTH: 60 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 60 Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala
Glu Thr Lys 1 5 10 15 Tyr Arg Val Leu Lys Thr Asp Arg Thr Glu Pro
Lys Asp Leu Val Ile 20 25 30 Ile Asp Asp Arg His Val Tyr Thr Gln
Gln Glu Val Arg Glu Leu Leu 35 40 45 Gly Arg Leu Asp Leu Gly Asn
Arg Thr Lys Met Gly 50 55 60 <210> SEQ ID NO 61 <211>
LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polynucleotide <400> SEQUENCE: 61 acagatgccc
cggtgagccc caccactctg tatgtggagg acatctcgga accgccgttg 60
cacgatttct accgcagcag gctactggac ctggtcttcc tgctggatgg ctcctccagg
120 ctgtccgagg ctgagtttga agtgctgaag gcctttgtgg tggacatgat
ggagcggctg 180 <210> SEQ ID NO 62 <211> LENGTH: 60
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polypeptide <400> SEQUENCE: 62 Thr Asp Ala Pro Val Ser Pro
Thr Thr Leu Tyr Val Glu Asp Ile Ser 1 5 10 15 Glu Pro Pro Leu His
Asp Phe Tyr Arg Ser Arg Leu Leu Asp Leu Val 20 25 30 Phe Leu Leu
Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val 35 40 45 Leu
Lys Ala Phe Val Val Asp Met Met Glu Arg Leu 50 55 60 <210>
SEQ ID NO 63 <211> LENGTH: 180 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 63 atctgtgctg ctgtcctcag caaattcatg tctgtgttct gcggggtata
tgagcagcca 60 tactactact ctgatatcct gacggtgggc tgtgctgtgg
gagtcggccg ttgttttggg 120 acaccacttg gaggagtgct atttagcatc
gaggtcacct ccacctactt tgctgttcgg 180 <210> SEQ ID NO 64
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 64 Ile Cys
Ala Ala Val Leu Ser Lys Phe Met Ser Val Phe Cys Gly Val 1 5 10 15
Tyr Glu Gln Pro Tyr Tyr Tyr Ser Asp Ile Leu Thr Val Gly Cys Ala 20
25 30 Val Gly Val Gly Arg Cys Phe Gly Thr Pro Leu Gly Gly Val Leu
Phe 35 40 45 Ser Ile Glu Val Thr Ser Thr Tyr Phe Ala Val Arg 50 55
60 <210> SEQ ID NO 65 <211> LENGTH: 180 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polynucleotide
<400> SEQUENCE: 65 tactttgaaa agtcaaagga gcagctgaca
cccctgatca agaaggctgg aacggaactg 60 gttaacttct tgagctattt
cgtggaactt ggaacacagc ctgccaccca gcgaagtgtc 120 cagcaccatt
gtcttccaac cccagctggc ctctagaaca cccactggcc agtcctagag 180
<210> SEQ ID NO 66 <211> LENGTH: 59 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 66 Tyr Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile
Lys Lys Ala 1 5 10 15 Gly Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe
Val Glu Leu Gly Thr 20 25 30 Gln Pro Ala Thr Gln Arg Ser Val Gln
His His Cys Leu Pro Thr Pro 35 40 45 Ala Gly Leu Asn Thr His Trp
Pro Val Leu Glu 50 55 <210> SEQ ID NO 67 <211> LENGTH:
180 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
Polynucleotide <400> SEQUENCE: 67 ccgcacaagc gcctcacgct
cagcggcatc tgcgccttca ttagtgaccg cttcccctac 60 taccgccgca
agttccccgc ccggcagaac agcatccgcc acaacctctc gctgaacgac 120
tgcttcgtca agatcccccg cgagccgggc cgcccaggca agggcaacta ctggagcctg
180 <210> SEQ ID NO 68 <211> LENGTH: 60 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 68 Pro His Lys Arg Leu Thr Leu Ser Gly Ile
Cys Ala Phe Ile Ser Asp 1 5 10 15 Arg Phe Pro Tyr Tyr Arg Arg Lys
Phe Pro Ala Arg Gln Asn Ser Ile 20 25 30 Arg His Asn Leu Ser Leu
Asn Asp Cys Phe Val Lys Ile Pro Arg Glu 35 40 45 Pro Gly Arg Pro
Gly Lys Gly Asn Tyr Trp Ser Leu 50 55 60 <210> SEQ ID NO 69
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 69
gctgaggacc tgtggctgag cccgctgacc atggaagatc ttgtctgcta cagcttccag
60 gtggccagag ggatggagtt cctggcttcc cgaaagtgca tccgcagaga
cctggctgct 120 cggaacattc tgctgtcgga aagcgacgtg gtgaagatct
gtgactttgg ccttgcccgg 180 <210> SEQ ID NO 70 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 70 Ala Glu Asp Leu Trp
Leu Ser Pro Leu Thr Met Glu Asp Leu Val Cys 1 5 10 15 Tyr Ser Phe
Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Arg Lys 20 25 30 Cys
Ile Arg Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Ser 35 40
45 Asp Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg 50 55 60
<210> SEQ ID NO 71 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 71 gataccgaga ctgtgggcca gagagccctg cactcaattc tgaatgctgc
catcatgatc 60 agtgtcgttg ttgtcatgac tatcctcctg gtggttctgt
ataaatacag gtgctataag 120
gtcatccatg cctggcttat tatatcatct ctattgttgc tgttcttttt ttcattcatt
180 <210> SEQ ID NO 72 <211> LENGTH: 60 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic Polypeptide
<400> SEQUENCE: 72 Asp Thr Glu Thr Val Gly Gln Arg Ala Leu
His Ser Ile Leu Asn Ala 1 5 10 15 Ala Ile Met Ile Ser Val Val Val
Val Met Thr Ile Leu Leu Val Val 20 25 30 Leu Tyr Lys Tyr Arg Cys
Tyr Lys Val Ile His Ala Trp Leu Ile Ile 35 40 45 Ser Ser Leu Leu
Leu Leu Phe Phe Phe Ser Phe Ile 50 55 60 <210> SEQ ID NO 73
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 73
aagccgagta agccaaaaac caacatgaag cacatggctg gtgctgcagc agctggggca
60 gtggtggggg gccttggcgg ctacgtgctg ggaagtgcca tgagcaggcc
catcatacat 120 ttcggcagtg actatgagga ccgttactat cgtgaaaaca
tgcaccgtta ccccaaccaa 180 <210> SEQ ID NO 74 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 74 Lys Pro Ser Lys Pro
Lys Thr Asn Met Lys His Met Ala Gly Ala Ala 1 5 10 15 Ala Ala Gly
Ala Val Val Gly Gly Leu Gly Gly Tyr Val Leu Gly Ser 20 25 30 Ala
Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp Tyr Glu Asp Arg 35 40
45 Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 50 55 60
<210> SEQ ID NO 75 <211> LENGTH: 120 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 75 cttcccagcc gagacgtgac agtccttctg gaaaactatg gcaaattcga
aaaggggtgt 60 ttgatttttg ttgtacgttt cctctttggc ctggtaaacc
aggagaggac ctcctacttg 120 <210> SEQ ID NO 76 <211>
LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 76 Leu Pro Ser Arg Asp
Val Thr Val Leu Leu Glu Asn Tyr Gly Lys Phe 1 5 10 15 Glu Lys Gly
Cys Leu Ile Phe Val Val Arg Phe Leu Phe Gly Leu Val 20 25 30 Asn
Gln Glu Arg Thr Ser Tyr Leu 35 40 <210> SEQ ID NO 77
<211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polynucleotide <400> SEQUENCE: 77
gtgaagcact tctccccaga ggaactcaaa gttaaggtgt tgggagatgt gattgaggtg
60 catggaaaac atgaagagcg ccaggatgaa catggtttca tctccaggga
gttccacggg 120 aaataccgga tcccagctga tgtagaccct ctcaccatta
cttcatccct gtcatctgat 180 <210> SEQ ID NO 78 <211>
LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic Polypeptide <400> SEQUENCE: 78 Val Lys His Phe Ser
Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 1 5 10 15 Val Ile Glu
Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 20 25 30 Phe
Ile Ser Arg Glu Phe His Gly Lys Tyr Arg Ile Pro Ala Asp Val 35 40
45 Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp 50 55 60
<210> SEQ ID NO 79 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 79 gagctgcact gtgacaagct gcacgtggat cctgagaact tcaggctcct
gggcaacgtg 60 ctggtctgtg tgccggccca tcactttggc aaagaattca
ccccaccagt gcaggctgcc 120 tatcagaaag tggtggctgg tgtggctaat
gccctggccc acaagtatca ctaagctcgc 180 <210> SEQ ID NO 80
<211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 80 Glu Leu
His Cys Asp Lys Leu His Val Asp Pro Glu Asn Phe Arg Leu 1 5 10 15
Leu Gly Asn Val Leu Val Cys Val Pro Ala His His Phe Gly Lys Glu 20
25 30 Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys Val Val Ala Gly
Val 35 40 45 Ala Asn Ala Leu Ala His Lys Tyr His Ala Arg 50 55
<210> SEQ ID NO 81 <211> LENGTH: 102 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 81 aucggaauct auuuugacuc guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 82 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 82 ucggaaucua uuuugacucg guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 83 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 83 cuuagauaaa acugagcaag guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 84 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 84 aucuauuuug acucguucuc guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 85 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 85 uaaaacugag caagaggcuu guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 86 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 86
ugguggcugg acaacaaaaa guuuuagagc uagaaauagc aaguuaaaau aaaggcuagu
60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102 <210>
SEQ ID NO 87 <211> LENGTH: 102 <212> TYPE: RNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 87 gcuggacaac aaaaauggau guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 88 <211> LENGTH: 102 <212> TYPE:
RNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 88 guguuaauuu gucguacgua guuuuagagc uagaaauagc aaguuaaaau
aaaggcuagu 60 ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uu 102
<210> SEQ ID NO 89 <211> LENGTH: 180 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polynucleotide <400>
SEQUENCE: 89 gcctccgcca acgtggactt cgctttcagc ctgtacaagc agttagtcct
gaaggcccct 60 gataagaatg tcatcttctc cccaccgagc atctccaccg
ccttggcctt cctgtctctg 120 ggggcccata ataccaccct gacagagatt
ctcaaaggcc tcaagttcta cctcacggag 180 <210> SEQ ID NO 90
<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 90 Ala Ser
Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Val 1 5 10 15
Leu Lys Ala Pro Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr 20
25 30 Lys Gln Leu Val Leu Lys Ala Pro Gly Ala His Asn Thr Thr Leu
Thr 35 40 45 Glu Ile Leu Lys Gly Leu Lys Phe Tyr Leu Thr Glu 50 55
60 <210> SEQ ID NO 91 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic Polypeptide <400>
SEQUENCE: 91 Gly Gly Gly Gly Ser 1 5 <210> SEQ ID NO 92
<211> LENGTH: 1636 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic Polypeptide <400> SEQUENCE: 92
Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Thr Ser Glu Lys 1 5
10 15 Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro
Trp 20 25 30 Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys
Glu Ala Cys 35 40 45 Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg
Lys Ile Trp Arg Ser 50 55 60 Ser Gly Lys Asn Thr Thr Asn His Val
Glu Val Asn Phe Ile Lys Lys 65 70 75 80 Phe Thr Ser Glu Arg Asp Phe
His Pro Ser Met Ser Cys Ser Ile Thr 85 90 95 Trp Phe Leu Ser Trp
Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg 100 105 110 Glu Phe Leu
Ser Arg His Pro Gly Val Thr Leu Val Ile Tyr Val Ala 115 120 125 Arg
Leu Phe Trp His Met Asp Gln Gln Asn Arg Gln Gly Leu Arg Asp 130 135
140 Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr
145 150 155 160 Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly
Asp Glu Ala 165 170 175 His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met
Leu Tyr Ala Leu Glu 180 185 190 Leu His Cys Ile Ile Leu Ser Leu Pro
Pro Cys Leu Lys Ile Ser Arg 195 200 205 Arg Trp Gln Asn His Leu Thr
Phe Phe Arg Leu His Leu Gln Asn Cys 210 215 220 His Tyr Gln Thr Ile
Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile 225 230 235 240 His Pro
Ser Val Ala Trp Arg Ser Pro Lys Lys Lys Arg Lys Val Glu 245 250 255
Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Lys Lys 260
265 270 Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala
Val 275 280 285 Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys
Val Leu Gly 290 295 300 Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu
Ile Gly Ala Leu Leu 305 310 315 320 Phe Asp Ser Gly Glu Thr Ala Glu
Ala Thr Arg Leu Lys Arg Thr Ala 325 330 335 Arg Arg Arg Tyr Thr Arg
Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 340 345 350 Ile Phe Ser Asn
Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 355 360 365 Leu Glu
Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 370 375 380
Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 385
390 395 400 Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr
Asp Lys 405 410 415 Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
Met Ile Lys Phe 420 425 430 Arg Gly His Phe Leu Ile Glu Gly Asp Leu
Asn Pro Asp Asn Ser Asp 435 440 445 Val Asp Lys Leu Phe Ile Gln Leu
Val Gln Thr Tyr Asn Gln Leu Phe 450 455 460 Glu Glu Asn Pro Ile Asn
Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 465 470 475 480 Ser Ala Arg
Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 485 490 495 Leu
Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 500 505
510 Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu
515 520 525 Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp
Leu Asp 530 535 540 Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp
Leu Phe Leu Ala 545 550 555 560 Ala Lys Asn Leu Ser Asp Ala Ile Leu
Leu Ser Asp Ile Leu Arg Val 565 570 575 Asn Thr Glu Ile Thr Lys Ala
Pro Leu Ser Ala Ser Met Ile Lys Arg 580 585 590 Tyr Asp Glu His His
Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 595 600 605 Gln Gln Leu
Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 610 615 620 Asn
Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 625 630
635 640 Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu
Glu 645 650 655 Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys
Gln Arg Thr 660 665 670 Phe Asp Asn Gly Ser Ile Pro His Gln Ile His
Leu Gly Glu Leu His 675 680 685 Ala Ile Leu Arg Arg Gln Glu Asp Phe
Tyr Pro Phe Leu Lys Asp Asn 690 695 700 Arg Glu Lys Ile Glu Lys Ile
Leu Thr Phe Arg Ile Pro Tyr Tyr Val 705 710 715 720 Gly Pro Leu Ala
Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 725 730 735 Ser Glu
Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 740 745 750
Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 755
760 765 Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr
Glu 770 775 780 Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr
Val Thr Glu 785 790 795 800 Gly Met Arg Lys Pro Ala Phe Leu Ser Gly
Glu Gln Lys Lys Ala Ile 805 810 815 Val Asp Leu Leu Phe Lys Thr Asn
Arg Lys Val Thr Val Lys Gln Leu 820 825 830 Lys Glu Asp Tyr Phe Lys
Lys Ile Glu Cys Phe Asp Ser Val Glu Ile
835 840 845 Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr
His Asp 850 855 860 Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp
Asn Glu Glu Asn 865 870 875 880 Glu Asp Ile Leu Glu Asp Ile Val Leu
Thr Leu Thr Leu Phe Glu Asp 885 890 895 Arg Glu Met Ile Glu Glu Arg
Leu Lys Thr Tyr Ala His Leu Phe Asp 900 905 910 Asp Lys Val Met Lys
Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 915 920 925 Arg Leu Ser
Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 930 935 940 Lys
Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 945 950
955 960 Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp
Ile 965 970 975 Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His
Glu His Ile 980 985 990 Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys
Gly Ile Leu Gln Thr 995 1000 1005 Val Lys Val Val Asp Glu Leu Val
Lys Val Met Gly Arg His Lys 1010 1015 1020 Pro Glu Asn Ile Val Ile
Glu Met Ala Arg Glu Asn Gln Thr Thr 1025 1030 1035 Gln Lys Gly Gln
Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 1040 1045 1050 Glu Gly
Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 1055 1060 1065
Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 1070
1075 1080 Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp
Ile 1085 1090 1095 Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val
Pro Gln Ser 1100 1105 1110 Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys
Val Leu Thr Arg Ser 1115 1120 1125 Asp Lys Asn Arg Gly Lys Ser Asp
Asn Val Pro Ser Glu Glu Val 1130 1135 1140 Val Lys Lys Met Lys Asn
Tyr Trp Arg Gln Leu Leu Asn Ala Lys 1145 1150 1155 Leu Ile Thr Gln
Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 1160 1165 1170 Gly Gly
Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 1175 1180 1185
Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu 1190
1195 1200 Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu
Ile 1205 1210 1215 Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu
Val Ser Asp 1220 1225 1230 Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val
Arg Glu Ile Asn Asn 1235 1240 1245 Tyr His His Ala His Asp Ala Tyr
Leu Asn Ala Val Val Gly Thr 1250 1255 1260 Ala Leu Ile Lys Lys Tyr
Pro Lys Leu Glu Ser Glu Phe Val Tyr 1265 1270 1275 Gly Asp Tyr Lys
Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser 1280 1285 1290 Glu Gln
Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser 1295 1300 1305
Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly 1310
1315 1320 Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr
Gly 1325 1330 1335 Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr
Val Arg Lys 1340 1345 1350 Val Leu Ser Met Pro Gln Val Asn Ile Val
Lys Lys Thr Glu Val 1355 1360 1365 Gln Thr Gly Gly Phe Ser Lys Glu
Ser Ile Leu Pro Lys Arg Asn 1370 1375 1380 Ser Asp Lys Leu Ile Ala
Arg Lys Lys Asp Trp Asp Pro Lys Lys 1385 1390 1395 Tyr Gly Gly Phe
Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val 1400 1405 1410 Val Ala
Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val 1415 1420 1425
Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu 1430
1435 1440 Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu
Val 1445 1450 1455 Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser
Leu Phe Glu 1460 1465 1470 Leu Glu Asn Gly Arg Lys Arg Met Leu Ala
Ser Ala Gly Glu Leu 1475 1480 1485 Gln Lys Gly Asn Glu Leu Ala Leu
Pro Ser Lys Tyr Val Asn Phe 1490 1495 1500 Leu Tyr Leu Ala Ser His
Tyr Glu Lys Leu Lys Gly Ser Pro Glu 1505 1510 1515 Asp Asn Glu Gln
Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 1520 1525 1530 Leu Asp
Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val 1535 1540 1545
Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn 1550
1555 1560 Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile
Ile 1565 1570 1575 His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala
Ala Phe Lys 1580 1585 1590 Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg
Tyr Thr Ser Thr Lys 1595 1600 1605 Glu Val Leu Asp Ala Thr Leu Ile
His Gln Ser Ile Thr Gly Leu 1610 1615 1620 Tyr Glu Thr Arg Ile Asp
Leu Ser Gln Leu Gly Gly Asp 1625 1630 1635
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