U.S. patent application number 14/079617 was filed with the patent office on 2015-05-14 for topical composition and method for skin treatment.
The applicant listed for this patent is Barry Knapp. Invention is credited to Barry Knapp.
Application Number | 20150132240 14/079617 |
Document ID | / |
Family ID | 46317107 |
Filed Date | 2015-05-14 |
United States Patent
Application |
20150132240 |
Kind Code |
A1 |
Knapp; Barry |
May 14, 2015 |
Topical Composition And Method For Skin Treatment
Abstract
A topical composition and method for skin treatment including a
wound healing agent in combination with a wound concealing agent,
is disclosed herein.
Inventors: |
Knapp; Barry; (Los Angeles,
CA) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
Knapp; Barry |
Los Angeles |
CA |
US |
|
|
Family ID: |
46317107 |
Appl. No.: |
14/079617 |
Filed: |
November 13, 2013 |
Current U.S.
Class: |
424/63 |
Current CPC
Class: |
A61K 8/891 20130101;
A61K 36/886 20130101; A61Q 17/00 20130101; A61Q 17/005 20130101;
A61K 31/047 20130101; A61K 2800/31 20130101; A61P 17/02 20180101;
A61Q 1/02 20130101; A61K 8/042 20130101; A61P 31/00 20180101; A61K
8/29 20130101; A61Q 19/00 20130101; A61K 31/05 20130101; A61K 8/922
20130101 |
Class at
Publication: |
424/63 |
International
Class: |
A61K 36/886 20060101
A61K036/886; A61K 31/05 20060101 A61K031/05; A61K 31/047 20060101
A61K031/047 |
Claims
1. A topical composition for skin treatment comprising a wound
healing agent in combination with a wound concealing agent.
2. The topical composition of claim 1, wherein the composition is a
gel-based plant derived water composition.
3. The topical composition of claim 2, where the water is derived
from an Aloe vera plant.
4. The topical composition of claim 1, wherein the composition is
one of a homogeneous cream or a homogenous ointment.
5. The topical composition of claim 4, wherein the wound healing
agent includes a disinfectant and a skin tissue rebuilding
agent.
6. The topical composition of claim 5, wherein the disinfectant
comprises Butylene Glycol and o-cymen-5-ol, and the skin tissue
rebuilding agent comprises Ceravitae.
7. The topical composition of claim 4, wherein the wound concealing
agent is a cosmetic mixture comprising one or more color pigments
whose percentage in the mixture is varied so that a resultant
cosmetic mixture color substantially matches a color of skin color
for treatment.
8. The topical composition of claim 1, wherein the composition is
one of a homogeneous cream or a homogenous ointment comprising a
gel-based plant derived water composition, wherein the wound
healing agent is a mixture of a disinfectant and a skin tissue
rebuilding agent, and wherein the wound concealing agent is a
cosmetic mixture comprising of one or more color pigments whose
percentage in the mixture is varied so that a resultant cosmetic
mixture color substantially matches a color skin for treatment.
9. The topical composition of claim 8, wherein the water is derived
from an Aloe vera plant.
10. The topical composition of claim 8, wherein the disinfectant
comprises Butylene Glycol and o-cymen-5-ol, and the skin tissue
rebuilding agent comprises Ceravitae.
Description
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims priority and the benefit of U.S.
patent application Ser. No. 12/927,398 filed on Nov. 15, 2010, the
disclosure of which is incorporated herein by reference in its
entirety.
TECHNICAL FIELD
[0002] The subject matter disclosed herein relates generally to a
topical composition and more particularly to compositions and
formulations applied as a skin treatment having a wound healing
agent in combination with a wound concealing agent.
BACKGROUND
[0003] Physicians typically prescribe wound healing ointments and
creams to protect and heal wounds caused by injury or by surgical
procedure. Swelling, bruising, or scarring that results from an
injury or surgery may take weeks or months to heal before the
detrimental effects disappear.
[0004] During the wound healing process petrolatum based ointments
serve to provide a protective barrier to contaminants, but do not
allow the skin to breath. Water and oil emulsion creams contain
moisturizers, but do not include active ingredients to promote
healing.
[0005] Numerous active healing agents such as nicotinic acid,
antibiotics, antioxidants, extracts of various herbs, steroids,
genetically engineered polypeptides, nitric oxide, enzymes, matrix
metalloproteinase inhibitors, honey and similar substances are
known in the art.
[0006] Municipal water derived from river or lake sources and used
for the manufacture of skin creams and lotions is subject to
agricultural runoff contaminated by pesticides. The water may be
filtered and chlorinated to disinfect the water, but chlorination
of mud related organic components in the water imparts chlorine by
products such as chloroform, a carcinogen to the water. See for
example, "Formation of chloroform by aqueous chlorination of
organic compounds", Chaidou, V. I. Georgakilas, C. Stalikas, M.
Saraci and E. S. Lahaniatis, Chemosphere Volume 39, Issue 4, August
1999, Pages 587-594. Chlorination of municipal water is
mandated.
[0007] As such, there is a need for a topical composition for skin
treatment comprising a wound healing agent in combination with a
wound concealing agent.
SUMMARY
[0008] For the purpose of summarizing the claimed subject matter
certain embodiments have been described. It is to be understood
that not all disclosed objects may be achieved in accordance with
any particular embodiment. Thus, for example, those skilled in the
art will recognize that the composition and method described herein
may be embodied or carried out in a manner that achieves or
optimizes one objective as taught herein without necessarily
achieving other objectives.
[0009] In one embodiment, a topical composition for skin treatment
comprises a wound healing agent in combination with a wound
concealing agent.
[0010] Various embodiments will become readily apparent to those
skilled in the art from the following detailed description having
reference to the attached figure, the subject matter described
herein not being limited to any particular embodiment(s)
disclosed.
BRIEF DESCRIPTION OF THE DRAWINGS
[0011] FIG. 1 shows an example of the basic constituents of a
topical composition for skin treatment comprising a wound healing
agent and a wound concealing agent, in accordance with one
embodiment of the present invention.
[0012] FIG. 2 is a flow chart illustrating an example method of
formulation of a topical composition for skin treatment comprising
a wound healing agent and a wound concealing agent, in accordance
with one embodiment of the present invention.
DETAILED DESCRIPTION
[0013] Exemplary embodiments will now be described with references
to the accompanying figures. The terminology used in the
description is not intended to be interpreted in any limited or
restrictive manner, simply because it is being utilized in
conjunction with a detailed description of certain embodiments.
Furthermore, various embodiments (whether or not specifically
described herein) may include novel features, no single one of
which is solely responsible for its desirable attributes or which
is essential to practicing the subject matter described herein.
[0014] As used herein the terms constituent, element, ingredient,
part, and item are generally understood to have the same
meaning.
[0015] As used herein the terms stirring, mixing, dispersing, and
mingling are generally understood to have the same meaning.
[0016] As used herein the terms formulating, creating, preparing,
manufacturing, and making are generally understood to have the same
meaning.
[0017] As used herein the term topical is generally understood to
mean applied to body surfaces such as the skin or mucous
membranes.
[0018] As used herein the term composition is generally understood
to mean a combination of parts or elements that make up something.
Other terms understood to have a similar meaning as composition
include arrangement and configuration.
[0019] In this regard, in one embodiment, a topical composition as
used herein may be understood to be an ointment, a cream, a salve,
a balm, a liniment, or a lotion that is applied to the skin as a
treatment for ailments, abnormalities, swelling, and wounds
including cuts, bruises, scars, abrasions, burns, and similar type
injuries.
[0020] As shown in FIG. 1, in one embodiment, the topical
composition disclosed herein for skin treatment comprises a wound
healing agent in combination with a wound concealing agent. The
topical composition may further include a foundation/base, a
thickener/binder, and a preservative/disinfectant.
[0021] In one example, the topical composition disclosed herein may
be considered is a gel based formulation that is non-clogging to
the skin and includes Ceravitae (wound healing agent) with a plant
based source of water (Aloe vera) and natural based preservative
which simultaneously serves as a disinfectant (O-cymen-5-ol),
includes a vegetable oil (grape seed oil), and also contains iron
oxides and titanium oxide (pigments) as wound concealing agents
that are well suited for use during the recovery phase following an
injury or surgical procedure.
[0022] In one example, the topical composition may be considered a
water in oil emulsion with a natural liquid being supplied by the
Aloe vera plant.
[0023] Aloe Barbadensis gel, popularly known as Aloe vera, has long
been used to heal wounds, see: "Anti-inflammatory and wound healing
activity of a growth substance in Aloe vera," Davis, R H: Donato, J
J: Hartman, G M: Haas, R C.: J-Am-Podiatr-Med-Assoc. 1994 Feb;
84(2): 77-81. In this regard, aloe accelerates wound healing when
compared with mafenide, see "Beneficial effect of Aloe on wound
healing in an excisional wound model." Heggers J P, Kucukcelebi A,
Listengarten D, Stabenau J, Ko F, Broemeling L D, Robson M C,
Winters W D, J. Ahern Complement Med. 1996 Summer; 2(2):271-7. This
effect appears to be due to an increased collagen activity, which
is enhanced by a lectin, consequently improving the collagen matrix
and enhancing the breaking strength of the scar. As the Aloe
Barbadensis gel is a watery liquid it may be used as a substitute
for commercially derived water in making a water/oil emulsion for
topical wound use.
[0024] In contrast to the aforementioned municipal water, water
derived from the Aloe plant is comparatively pure and relatively
uncontaminated. Although many water retaining plants may be used as
a source of water, Aloe has traditional been used most often.
[0025] The topical composition for skin treatment may include a
skin respiratory factor (Ceravitae) designed to permit, among other
things, uninhibited exposure of the treated skin to oxygen from the
air to promote oxygenation and healing of the wound. Ceravitae is
manufactured, prepared, and retained as a trade secret by
Oxygenetic Institute, Inc., of Reno N.V., and is a complex
ingredient of the topical composition disclosed herein. Ceravitae
may be considered as a skin respiratory factor and disinfectant
designed to increase oxygen uptake and skin cell production as well
as promote the healing process. In this regard, Ceravitae contains
a live yeast cell derivative/Aloe vera (Aloe Barbadensis)/grape
seed extract.
[0026] The adaptive skin respiratory factors in the live yeast cell
derivative can be extracted from the nucleuses of yeast or
Saccharomyces cerevisiae cells after the yeast has been cultured in
nutritional media and then stressed by means including, but not
limited to heat, oxidant or irradiation by UV radiation.
Irradiation and especially elevated temperatures produce stressed
proteins in all cells, see (Demple, B. 1998). These stresses cause
cellular proteins to lose their three-dimensional structure, and
the adapting yeast cells produce heat stressed proteins that are
capable of restoring them to the original configuration. If the
protoplasm of the cell is concentrated, a yeast extract may be
obtained called Adapted Yeast Extract (AYE). The AYE can be
prepared as an alcohol extract of viable Saccharomyces lysate. By
normalizing the structure of matrix cells, AYE stimulates wound
oxygen consumption or uptake, epitheliazation, and collagen
synthesis. In topical preparations, AYE is characterized and
quantified in terms of skin respiratory ability, which is the
increased ability to utilize oxygen and produce extracellular
matrix.
[0027] AYE-biofactors extracted from Saccharomyces cerevisiae also
contain nutrients such as peptides, proteins, amino acids, minerals
carbohydrates, nucleic acid, and other genetic products. After
processing, AYE-biofactors are clear and sediment-free, retaining
the active components without the dark color or odor of the
starting material see (Fishman, H. M. 2001 "Yeast Has Applications
In The Cosmetics Industry", HAPPI, July, 42), see also Lods, L., D.
Scholz, C. Dres, C. Johnson & G. Brooks. 2000,
"Peroxide-Inducible Protective Factors Produced by Saccharomyces
Cerevisiae," Cosmet & Toil 115(12) 61-6. See also Fishman, H.
M. 2001, "Yeast Has Applications In The Cosmetics Industry", HAPPI,
July, 42). Further, when delivered to the lower strata of the skin,
AYE biofactors stimulate oxygen consumption by viable cells,
causing cellular proliferation and collagen and elastin
synthesis.
[0028] As shown in FIG. 2, in one embodiment, a method or process
of formulating the topical composition for skin treatment may
include the following steps.
[0029] Add a foundation/base to a first container. The
foundation/base may include one or more of the following items,
Isododecane (Fanning Corp) 14%, butylene ethylene/propylene
copolymer (Arch Personal Care) 4%, cyclopentasiloxane and
PEG/PPG-20 dimethicone (Botanigenics Inc) 5.00%, grape seed oil
1.00%, and Dioctyl dodecanedioate (Arch Personal care) 2.00%.
[0030] Add a wound concealing agent to the first container.
[0031] Stir the wound concealing agent in the first container.
[0032] The wound concealing agent may include one or more pigments.
The one or more pigments may be considered a cosmetic mixture and
include titanium dioxide coated with methicone R434 (Sensient
Cosmetic Technologie) 9.35%, yellow iron oxide coated with
methicone R0242 (Sensient Cosmetic Technologie) 0.75%, red iron
oxide coated with methicone R0241 (Sensient Cosmetic Technologie),
0.28%, black iron oxide coated with methicone R0243 (Sensient
Cosmetic Technologie) 0.05%. The percentages of the one or more
pigments may vary from 0.01 to 3% to substantially or generally
match a skin color/pigment of a patient, person, or individual
designated for treatment with the topical composition.
[0033] Once the one or more pigments are thoroughly mixed, for
example, into a homogenous mixture, a thickener/binder may be mixed
into the first container. The thickener/binder may include
cyclopentasiloxane and disteardimonium hectorite (Elementis Corp)
1.50% and silica (Cabo Sil Corp). Mixing of the entire contents of
the first container (foundation/base, wound concealing agent, and
thickener/binder) may continue until the constituents are
thoroughly mixed, for example, into a homogenous mixture.
[0034] The topical composition disclosed herein may include the use
of naturally based materials to prevent infection in the wound. One
such naturally based material is o-cymen-5-ol. O-cymen-5-ol is a
homologue of thymol, the active constituent of Thymus vulgaris or
Thyme oil. One provider of this material is Barnett Products Corp.,
under the name of NET DTB. O-cymen-5-ol kills yeast, mold, and
bacteria and is a natural replacement for triclosan. It has a
minimum growth inhibitory concentration against bacterial species,
yeast, and mold of 0.01% that is superior to parabens, salicylic
acid, and benzoic acid. The inhibitory values were provided by
Barnett Products Corporation, Englewood Cliffs, N.J. 07632. The
safety of o-cymen-5-ol has been assessed up to 0.5% and typical use
is 0.1%.
[0035] The method or process of formulating the topical composition
for skin treatment proceeds by adding a preservative/disinfectant
to a second container. The preservative/disinfectant may include
butylene glycol, 2.50% and o-cymen-5-ol (Barnett products NET DTB)
0.10%. Heat is then applied to the contents of the second container
at approximately 40.degree. C. to 50.degree. C., and stirring of
the contents of the second container is commenced until the
contents are dissolved.
[0036] Add the contents of container B to the contents of container
A and stir till the constituents are mixed.
[0037] Add a wound healing agent/tissue rebuilding agent to a third
container. The wound healing agent/tissue rebuilding agent may
include one or more of the following items, Aloe vera gel
(Aloecorp) 49.5%, Ceravitae (Oxygenetix Institute, Inc.) 2.80%, and
salt 1.0%.
[0038] The percentage of Aloe vera may be varied depending on the
percentage of iron oxides (pigments) in order to make the total
percentage of constituents in the topical composition one hundred
percent. Once the wound healing agent/tissue rebuilding agent is
added and mixed together in the third container, the contents of
the third container are added slowly to the contents of the first
container, and stirred, for example, with a sweep rotor until a
homogeneous ointment, cream, salve, balm, liniment, or lotion is
formed.
[0039] Those of ordinary skill in the art will appreciate that the
commercially available ingredients listed above are exemplary only,
and that the elements in the formulation may be obtained using
ingredients other than those listed above. In addition those of
ordinary skill in the art will appreciate that the amount of any
ingredient or ingredients listed above can be varied depending on
the desired thickness, consistency, and ability to spread or apply
the final product (topical composition) to the skin.
[0040] Furthermore, those skilled in art will understand that the
order of steps in the method or process of formulating the topical
composition for skin treatment may be varied and that the order
provided above is just one example of the order of steps in the
method or process.
[0041] In addition, those skilled in the art will understand that
one or more of the items that constitute the topical composition
may be considered to have multiple properties, characteristics, or
features. For example, grape seed oil is identified as an item used
in the foundation/base of the topical composition, but grape seed
oil may be also considered as a hydrating agent. Similarly, silica
may be considered a hydrating agent. Aloe vera gel may be
considered a hydrating agent. Ceravitae may be considered as a
respiratory factor.
[0042] This unique combination of ingredients allows the skin to
appear undamaged with the wound concealing agent while
simultaneously promoting healing of the wound or injury with the
wound healing agent.
[0043] The topical composition and methods of the claimed subject
matter have been described with some particularity, but the
specific designs, constructions and steps disclosed are not to be
taken as delimiting of the subject matter. Obvious modifications
will make themselves apparent to those of ordinary skill in the
art, all of which will not depart from the essence of the claimed
subject matter and all such changes and modifications are intended
to be encompassed within the appended claims.
* * * * *