U.S. patent application number 14/322852 was filed with the patent office on 2015-05-07 for fusion proteins forming trimers. The applicant listed for this patent is Apogenix GmbH. Invention is credited to Marcus Branschadel, Christian Gieffers, Oliver HILL, Meinolf Thiemann.
Application Number | 20150126710 14/322852 |
Document ID | / |
Family ID | 40626882 |
Filed Date | 2015-05-07 |
United States Patent Application | 20150126710 |
Kind Code | A1 |
HILL; Oliver ; et al. | May 7, 2015 |
The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.
Inventors: | HILL; Oliver; (Neckarsteinach, DE) ; Branschadel; Marcus; (Heidelberg, DE) ; Gieffers; Christian; (Dossenheim, DE) ; Thiemann; Meinolf; (Schriesheim, DE) | ||||||||||
Applicant: |
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Family ID: | 40626882 | ||||||||||
Appl. No.: | 14/322852 | ||||||||||
Filed: | July 2, 2014 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14160240 | Jan 21, 2014 | |||
14322852 | ||||
13143531 | Sep 6, 2011 | 8664366 | ||
PCT/EP2009/050233 | Jan 9, 2009 | |||
14160240 | ||||
Current U.S. Class: | 530/351 |
Current CPC Class: | C07K 2319/70 20130101; C07K 2319/22 20130101; C07K 2319/00 20130101; A61P 3/00 20180101; A61P 37/06 20180101; C07K 2319/21 20130101; A61P 31/00 20180101; C07K 16/00 20130101; C07K 14/4726 20130101; A61P 35/00 20180101; C07K 7/06 20130101; C07K 14/00 20130101; C07K 14/70575 20130101; C12N 15/62 20130101; A61P 37/02 20180101; C07K 14/525 20130101 |
Class at Publication: | 530/351 |
International Class: | C07K 14/525 20060101 C07K014/525; C07K 7/06 20060101 C07K007/06; C07K 14/47 20060101 C07K014/47 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 63 <210> SEQ ID NO 1 <211> LENGTH: 205 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (59)..(205)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (60)..(205) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_000586 <309>
DATABASE ENTRY DATE: 2009-01-04 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(205) <400> SEQUENCE: 1 Met Thr Pro Pro Glu
Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 1 5 10 15 Leu His Leu
Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 20 25 30 Gln
Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 35 40
45 Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala
50 55 60 Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu
Trp Arg 65 70 75 80 Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe
Ser Leu Ser Asn 85 90 95 Asn Ser Leu Leu Val Pro Thr Ser Gly Ile
Tyr Phe Val Tyr Ser Gln 100 105 110 Val Val Phe Ser Gly Lys Ala Tyr
Ser Pro Lys Ala Thr Ser Ser Pro 115 120 125 Leu Tyr Leu Ala His Glu
Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 130 135 140 His Val Pro Leu
Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 145 150 155 160 Glu
Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 165 170
175 Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val
180 185 190 Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 195
200 205 <210> SEQ ID NO 2 <211> LENGTH: 233 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (86)..(233)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_000585 <309> DATABASE ENTRY DATE: 2008-12-28
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(233) <400>
SEQUENCE: 2 Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu
Glu Ala 1 5 10 15 Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg
Arg Cys Leu Phe 20 25 30 Leu Ser Leu Phe Ser Phe Leu Ile Val Ala
Gly Ala Thr Thr Leu Phe 35 40 45 Cys Leu Leu His Phe Gly Val Ile
Gly Pro Gln Arg Glu Glu Phe Pro 50 55 60 Arg Asp Leu Ser Leu Ile
Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 65 70 75 80 Ser Arg Thr Pro
Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 85 90 95 Gln Ala
Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 100 105 110
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 115
120 125 Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln
Gly 130 135 140 Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser
Arg Ile Ala 145 150 155 160 Val Ser Tyr Gln Thr Lys Val Asn Leu Leu
Ser Ala Ile Lys Ser Pro 165 170 175 Cys Gln Arg Glu Thr Pro Glu Gly
Ala Glu Ala Lys Pro Trp Tyr Glu 180 185 190 Pro Ile Tyr Leu Gly Gly
Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 195 200 205 Ser Ala Glu Ile
Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 210 215 220 Gln Val
Tyr Phe Gly Ile Ile Ala Leu 225 230 <210> SEQ ID NO 3
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (82)..(244) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (86)..(244) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_002332 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(244) <400> SEQUENCE: 3
Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 1 5
10 15 Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr
Leu 20 25 30 Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala
Leu Val Pro 35 40 45 Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala
Asp Pro Gly Ala Gln 50 55 60 Ala Gln Gln Gly Leu Gly Phe Gln Lys
Leu Pro Glu Glu Glu Pro Glu 65 70 75 80 Thr Asp Leu Ser Pro Gly Leu
Pro Ala Ala His Leu Ile Gly Ala Pro 85 90 95 Leu Lys Gly Gln Gly
Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 100 105 110 Leu Thr Ser
Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 115 120 125 Gln
Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 130 135
140 Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg
145 150 155 160 Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly
Thr Pro Glu 165 170 175 Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro
Val Leu Asp Pro Ala 180 185 190 Arg Arg Gln Gly Tyr Gly Pro Leu Trp
Tyr Thr Ser Val Gly Phe Gly 195 200 205 Gly Leu Val Gln Leu Arg Arg
Gly Glu Arg Val Tyr Val Asn Ile Ser 210 215 220 His Pro Asp Met Val
Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 225 230 235 240 Val Met
Val Gly <210> SEQ ID NO 4 <211> LENGTH: 183 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (52)..(183)
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (55)..(183) <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_003317 <309>
DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(183) <400> SEQUENCE: 4 Met Glu Arg Val Gln
Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 1 5 10 15 Pro Arg Phe
Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 20 25 30 Gly
Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 35 40
45 Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val
50 55 60 Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr
Ser Gln 65 70 75 80 Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser
Val Ile Ile Asn 85 90 95 Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys
Gly Tyr Phe Ser Gln Glu 100 105 110 Val Asn Ile Ser Leu His Tyr Gln
Lys Asp Glu Glu Pro Leu Phe Gln 115 120 125 Leu Lys Lys Val Arg Ser
Val Asn Ser Leu Met Val Ala Ser Leu Thr 130 135 140 Tyr Lys Asp Lys
Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 145 150 155 160 Asp
Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 165 170
175 Pro Gly Glu Phe Cys Val Leu 180 <210> SEQ ID NO 5
<211> LENGTH: 261 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (112)..(261) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (117)..(261) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_000065 <309> DATABASE ENTRY DATE: 2008-12-28 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(261) <400> SEQUENCE: 5
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 1 5
10 15 Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe
Leu 20 25 30 Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr
Leu His Arg 35 40 45 Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu
His Glu Asp Phe Val 50 55 60 Phe Met Lys Thr Ile Gln Arg Cys Asn
Thr Gly Glu Arg Ser Leu Ser 65 70 75 80 Leu Leu Asn Cys Glu Glu Ile
Lys Ser Gln Phe Glu Gly Phe Val Lys 85 90 95 Asp Ile Met Leu Asn
Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 100 105 110 Met Gln Lys
Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 115 120 125 Glu
Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 130 135
140 Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln
145 150 155 160 Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala
Gln Val Thr 165 170 175 Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala
Pro Phe Ile Ala Ser 180 185 190 Leu Cys Leu Lys Ser Pro Gly Arg Phe
Glu Arg Ile Leu Leu Arg Ala 195 200 205 Ala Asn Thr His Ser Ser Ala
Lys Pro Cys Gly Gln Gln Ser Ile His 210 215 220 Leu Gly Gly Val Phe
Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 225 230 235 240 Val Thr
Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 245 250 255
Gly Leu Leu Lys Leu 260 <210> SEQ ID NO 6 <211> LENGTH:
281 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (142)..(281) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (144)..(281) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_000630 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(281) <400> SEQUENCE: 6
Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 1 5
10 15 Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro
Cys 20 25 30 Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro
Pro Pro Pro 35 40 45 Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro
Pro Pro Pro Leu Pro 50 55 60 Pro Leu Pro Leu Pro Pro Leu Lys Lys
Arg Gly Asn His Ser Thr Gly 65 70 75 80 Leu Cys Leu Leu Val Met Phe
Phe Met Val Leu Val Ala Leu Val Gly 85 90 95 Leu Gly Leu Gly Met
Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 100 105 110 Glu Leu Arg
Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 115 120 125 Lys
Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 130 135
140 Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu
145 150 155 160 Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly
Val Lys Tyr 165 170 175 Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly
Leu Tyr Phe Val Tyr 180 185 190 Ser Lys Val Tyr Phe Arg Gly Gln Ser
Cys Asn Asn Leu Pro Leu Ser 195 200 205 His Lys Val Tyr Met Arg Asn
Ser Lys Tyr Pro Gln Asp Leu Val Met 210 215 220 Met Glu Gly Lys Met
Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 225 230 235 240 Arg Ser
Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 245 250 255
Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 260
265 270 Gln Thr Phe Phe Gly Leu Tyr Lys Leu 275 280 <210> SEQ
ID NO 7 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (51)..(193) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (56)..(193)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_001243 <309> DATABASE ENTRY DATE: 2008-12-14
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(193) <400>
SEQUENCE: 7 Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro
Tyr Gly 1 5 10 15 Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala
Gly Leu Val Ile 20 25 30 Cys Leu Val Val Cys Ile Gln Arg Phe Ala
Gln Ala Gln Gln Gln Leu 35 40 45 Pro Leu Glu Ser Leu Gly Trp Asp
Val Ala Glu Leu Gln Leu Asn His 50 55 60 Thr Gly Pro Gln Gln Asp
Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 65 70 75 80 Leu Gly Arg Ser
Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 85 90 95 Arg Ile
His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 100 105 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 115
120 125 Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu
Arg 130 135 140 Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg
Leu Thr Pro 145 150 155 160 Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn
Leu Thr Gly Thr Leu Leu 165 170 175 Pro Ser Arg Asn Thr Asp Glu Thr
Phe Phe Gly Val Gln Trp Val Arg 180 185 190 Pro <210> SEQ ID
NO 8 <211> LENGTH: 234 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (97)..(234) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (98)..(234)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (102)..(234) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_001235 <309>
DATABASE ENTRY DATE: 2008-09-28 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(234) <400> SEQUENCE: 8 Met Asp Pro Gly Leu
Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 1 5 10 15 Asp Thr Ala
Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 20 25 30 Thr
Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 35 40
45 Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg
50 55 60 Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys
Gly Gly 65 70 75 80 Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg
Ala Pro Phe Lys 85 90 95 Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys
His Leu Asn Lys Thr Lys 100 105 110 Leu Ser Trp Asn Lys Asp Gly Ile
Leu His Gly Val Arg Tyr Gln Asp 115 120 125 Gly Asn Leu Val Ile Gln
Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 130 135 140 Leu Gln Phe Leu
Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 145 150 155 160 Glu
Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 165 170
175 Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln
180 185 190 Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val
Asn Val 195 200 205 Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro
Leu Glu Asn Val 210 215 220 Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp
225 230 <210> SEQ ID NO 9 <211> LENGTH: 254 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (86)..(254)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_003802 <309> DATABASE ENTRY DATE: 2008-10-24
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(254) <400>
SEQUENCE: 9 Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro
Trp Pro 1 5 10 15 Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro
Trp Ala Leu Val 20 25 30 Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala
Ala Ala Cys Ala Val Phe 35 40 45 Leu Ala Cys Pro Trp Ala Val Ser
Gly Ala Arg Ala Ser Pro Gly Ser 50 55 60 Ala Ala Ser Pro Arg Leu
Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 65 70 75 80 Pro Ala Gly Leu
Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 85 90 95 Ala Gln
Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 100 105 110
Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 115
120 125 Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val
Phe 130 135 140 Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly
Ser Gly Ser 145 150 155 160 Val Ser Leu Ala Leu His Leu Gln Pro Leu
Arg Ser Ala Ala Gly Ala 165 170 175 Ala Ala Leu Ala Leu Thr Val Asp
Leu Pro Pro Ala Ser Ser Glu Ala 180 185 190 Arg Asn Ser Ala Phe Gly
Phe Gln Gly Arg Leu Leu His Leu Ser Ala 195 200 205 Gly Gln Arg Leu
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 210 215 220 Ala Trp
Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 225 230 235
240 Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 245 250
<210> SEQ ID NO 10 <211> LENGTH: 281 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (95)..(281)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (116)..(281) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (117)..(281) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (118)..(281)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (119)..(281) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (120)..(281) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_003801 <309> DATABASE ENTRY DATE: 2008-12-28 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(281) <400> SEQUENCE: 10
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 1 5
10 15 Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val
Ala 20 25 30 Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met
Gln Asp Lys 35 40 45 Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys
Glu Asp Asp Ser Tyr 50 55 60 Trp Asp Pro Asn Asp Glu Glu Ser Met
Asn Ser Pro Cys Trp Gln Val 65 70 75 80 Lys Trp Gln Leu Arg Gln Leu
Val Arg Lys Met Ile Leu Arg Thr Ser 85 90 95 Glu Glu Thr Ile Ser
Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 100 105 110 Leu Val Arg
Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 115 120 125 Thr
Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 130 135
140 Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly
145 150 155 160 His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu
Leu Val Ile 165 170 175 His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln
Thr Tyr Phe Arg Phe 180 185 190 Gln Glu Glu Ile Lys Glu Asn Thr Lys
Asn Asp Lys Gln Met Val Gln 195 200 205 Tyr Ile Tyr Lys Tyr Thr Ser
Tyr Pro Asp Pro Ile Leu Leu Met Lys 210 215 220 Ser Ala Arg Asn Ser
Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 225 230 235 240 Ser Ile
Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 245 250 255
Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 260
265 270 Ser Phe Phe Gly Ala Phe Leu Val Gly 275 280 <210> SEQ
ID NO 11 <211> LENGTH: 317 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (161)..(317) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_003692 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(317) <400> SEQUENCE: 11
Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 1 5
10 15 Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His
Ala 20 25 30 Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser
Arg Ser Met 35 40 45 Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln
Val Val Cys Ser Val 50 55 60 Ala Leu Phe Phe Tyr Phe Arg Ala Gln
Met Asp Pro Asn Arg Ile Ser 65 70 75 80 Glu Asp Gly Thr His Cys Ile
Tyr Arg Ile Leu Arg Leu His Glu Asn 85 90 95 Ala Asp Phe Gln Asp
Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 100 105 110 Pro Asp Ser
Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 115 120 125 Lys
Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 130 135
140 Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu
145 150 155 160 Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr
Asp Ile Pro 165 170 175 Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp
Tyr His Asp Arg Gly 180 185 190 Trp Ala Lys Ile Ser Asn Met Thr Phe
Ser Asn Gly Lys Leu Ile Val 195 200 205 Asn Gln Asp Gly Phe Tyr Tyr
Leu Tyr Ala Asn Ile Cys Phe Arg His 210 215 220 His Glu Thr Ser Gly
Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 225 230 235 240 Tyr Val
Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 245 250 255
Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 260
265 270 Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu
Glu 275 280 285 Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro
Asp Gln Asp 290 295 300 Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp
Ile Asp 305 310 315 <210> SEQ ID NO 12 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (103)..(249) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (104)..(249) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (105)..(249)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_003800 <309> DATABASE ENTRY DATE: 2008-11-05
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(249) <400>
SEQUENCE: 12 Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg
Gly Glu Pro 1 5 10 15 Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly
Leu Gly Leu Ala Leu 20 25 30 Ala Cys Leu Gly Leu Leu Leu Ala Val
Val Ser Leu Gly Ser Arg Ala 35 40 45 Ser Leu Ser Ala Gln Glu Pro
Ala Gln Glu Glu Leu Val Ala Glu Glu 50 55 60 Asp Gln Asp Pro Ser
Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 65 70 75 80 Pro Ala Pro
Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 85 90 95 Lys
Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 100 105
110 Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly
115 120 125 Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser
Pro Leu 130 135 140 Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr
Arg Ala Gly Leu 145 150 155 160 Tyr Tyr Leu Tyr Cys Gln Val His Phe
Asp Glu Gly Lys Ala Val Tyr 165 170 175 Leu Lys Leu Asp Leu Leu Val
Asp Gly Val Leu Ala Leu Arg Cys Leu 180 185 190 Glu Glu Phe Ser Ala
Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 195 200 205 Leu Cys Gln
Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 210 215 220 Arg
Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 225 230
235 240 Thr Tyr Phe Gly Leu Phe Gln Val His 245 <210> SEQ ID
NO 13 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (112)..(247) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (113)..(247)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_742085 <309> DATABASE ENTRY DATE: 2008-11-05
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(247) <400>
SEQUENCE: 13 Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly
Pro Pro Gly 1 5 10 15 Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu
Ser Val Ala Leu Trp 20 25 30 Leu Ser Trp Gly Ala Ala Leu Gly Ala
Val Ala Cys Ala Met Ala Leu 35 40 45 Leu Thr Gln Gln Thr Glu Leu
Gln Ser Leu Arg Arg Glu Val Ser Arg 50 55 60 Leu Gln Gly Thr Gly
Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 65 70 75 80 Gln Ser Leu
Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 85 90 95 Gly
Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 100 105
110 Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys
115 120 125 Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu
Arg Arg 130 135 140 Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg
Ile Gln Asp Ala 145 150 155 160 Gly Val Tyr Leu Leu Tyr Ser Gln Val
Leu Phe Gln Asp Val Thr Phe 165 170 175 Thr Met Gly Gln Val Val Ser
Arg Glu Gly Gln Gly Arg Gln Glu Thr 180 185 190 Leu Phe Arg Cys Ile
Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 195 200 205 Asn Ser Cys
Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 210 215 220 Leu
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 225 230
235 240 His Gly Thr Phe Leu Gly Leu 245 <210> SEQ ID NO 14
<211> LENGTH: 250 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (112)..(250) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (113)..(250) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_003799 <309> DATABASE ENTRY DATE: 2008-11-05 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(250) <400> SEQUENCE: 14
Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 1 5
10 15 Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu
Trp 20 25 30 Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala
Met Ala Leu 35 40 45 Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg
Arg Glu Val Ser Arg 50 55 60 Leu Gln Gly Thr Gly Gly Pro Ser Gln
Asn Gly Glu Gly Tyr Pro Trp 65 70 75 80 Gln Ser Leu Pro Glu Gln Ser
Ser Asp Ala Leu Glu Ala Trp Glu Asn 85 90 95 Gly Glu Arg Ser Arg
Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 100 105 110 Lys Gln His
Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 115 120 125 Asp
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 130 135
140 Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala
145 150 155 160 Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp
Val Thr Phe 165 170 175 Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln
Gly Arg Gln Glu Thr 180 185 190 Leu Phe Arg Cys Ile Arg Ser Met Pro
Ser His Pro Asp Arg Ala Tyr 195 200 205 Asn Ser Cys Tyr Ser Ala Gly
Val Phe His Leu His Gln Gly Asp Ile 210 215 220 Leu Ser Val Ile Ile
Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 225 230 235 240 His Gly
Thr Phe Leu Gly Phe Val Lys Leu 245 250 <210> SEQ ID NO 15
<211> LENGTH: 285 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (140)..(285) <223> OTHER INFORMATION:
Preferred receptor binding domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NP_006564
<309> DATABASE ENTRY DATE: 2008-02-11 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(285) <400> SEQUENCE: 15 Met Asp
Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 1 5 10 15
Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 20
25 30 Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu
Leu 35 40 45 Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu
Thr Val Val 50 55 60 Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp
Leu Ala Ser Leu Arg 65 70 75 80 Ala Glu Leu Gln Gly His His Ala Glu
Lys Leu Pro Ala Gly Ala Gly 85 90 95 Ala Pro Lys Ala Gly Leu Glu
Glu Ala Pro Ala Val Thr Ala Gly Leu 100 105 110 Lys Ile Phe Glu Pro
Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 115 120 125 Ser Arg Asn
Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 130 135 140 Asp
Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 145 150
155 160 Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly
Ser 165 170 175 Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu
Thr Gly Tyr 180 185 190 Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp
Lys Thr Tyr Ala Met 195 200 205 Gly His Leu Ile Gln Arg Lys Lys Val
His Val Phe Gly Asp Glu Leu 210 215 220 Ser Leu Val Thr Leu Phe Arg
Cys Ile Gln Asn Met Pro Glu Thr Leu 225 230 235 240 Pro Asn Asn Ser
Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 245 250 255 Asp Glu
Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 260 265 270
Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 275 280 285
<210> SEQ ID NO 16 <211> LENGTH: 240 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (91)..(240)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_003798 <309> DATABASE ENTRY DATE: 2008-12-21
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(240) <400>
SEQUENCE: 16 Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val
Asp Gly Gln 1 5 10 15 Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser
His Arg Arg Gln Ser 20 25 30 Cys Ser Val Ala Arg Val Gly Leu Gly
Leu Leu Leu Leu Leu Met Gly 35 40 45 Ala Gly Leu Ala Val Gln Gly
Trp Phe Leu Leu Gln Leu His Trp Arg 50 55 60 Leu Gly Glu Met Val
Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 65 70 75 80 Glu Gln Leu
Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 85 90 95 His
Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 100 105
110 Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr
115 120 125 His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr
Ile Tyr 130 135 140 Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu
Gly Leu Ala Ser 145 150 155 160 Thr Ile Thr His Gly Leu Tyr Lys Arg
Thr Pro Arg Tyr Pro Glu Glu 165 170 175 Leu Glu Leu Leu Val Ser Gln
Gln Ser Pro Cys Gly Arg Ala Thr Ser 180 185 190 Ser Ser Arg Val Trp
Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 195 200 205 Leu Glu Ala
Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 210 215 220 Val
Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 225 230
235 240 <210> SEQ ID NO 17 <211> LENGTH: 251
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (91)..(251) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (93)..(251) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_005109 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(251) <400> SEQUENCE: 17
Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 1 5
10 15 Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser
Ser 20 25 30 Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro
Phe Leu Ala 35 40 45 Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu
Arg Ala Gln Gly Glu 50 55 60 Ala Cys Val Gln Phe Gln Ala Leu Lys
Gly Gln Glu Phe Ala Pro Ser 65 70 75 80 His Gln Gln Val Tyr Ala Pro
Leu Arg Ala Asp Gly Asp Lys Pro Arg 85 90 95 Ala His Leu Thr Val
Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 100 105 110 Gln Phe Pro
Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 115 120 125 Lys
Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 130 135
140 Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser
145 150 155 160 Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys
Pro Asp Ser 165 170 175 Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser
Tyr Pro Glu Pro Thr 180 185 190 Gln Leu Leu Met Gly Thr Lys Ser Val
Cys Glu Val Gly Ser Asn Trp 195 200 205 Phe Gln Pro Ile Tyr Leu Gly
Ala Met Phe Ser Leu Gln Glu Gly Asp 210 215 220 Lys Leu Met Val Asn
Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 225 230 235 240 Glu Asp
Lys Thr Phe Phe Gly Ala Phe Leu Leu 245 250 <210> SEQ ID NO
18 <211> LENGTH: 199 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (52)..(177) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_005083 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(199) <400> SEQUENCE: 18
Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 1 5
10 15 Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met
Pro 20 25 30 Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser
Trp Lys Leu 35 40 45 Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe
Leu Cys Ser Phe Ser 50 55 60 Trp Leu Ile Phe Ile Phe Leu Gln Leu
Glu Thr Ala Lys Glu Pro Cys 65 70 75 80 Met Ala Lys Phe Gly Pro Leu
Pro Ser Lys Trp Gln Met Ala Ser Ser 85 90 95 Glu Pro Pro Cys Val
Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 100 105 110 Gln Asn Gly
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 115 120 125 Tyr
Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 130 135
140 Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly
145 150 155 160 Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile
Phe Asn Ser 165 170 175 Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp
Gly Ile Ile Leu Leu 180 185 190 Ala Asn Pro Gln Phe Ile Ser 195
<210> SEQ ID NO 19 <211> LENGTH: 391 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (245)..(391)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_001390 <309> DATABASE ENTRY DATE: 2008-12-21
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(391) <400>
SEQUENCE: 19 Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro
Ala Ala Ala 1 5 10 15 Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys
Gly Gly Ala Pro Ala 20 25 30 Arg Ala Gly Glu Gly Asn Ser Cys Leu
Leu Phe Leu Gly Phe Phe Gly 35 40 45 Leu Ser Leu Ala Leu His Leu
Leu Thr Leu Cys Cys Tyr Leu Glu Leu 50 55 60 Arg Ser Glu Leu Arg
Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 65 70 75 80 Ser Gly Thr
Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 85 90 95 Asp
Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 100 105
110 Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln
115 120 125 Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp
Glu Lys 130 135 140 Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg
Asn Lys Arg Ser 145 150 155 160 Lys Ser Asn Glu Gly Ala Asp Gly Pro
Val Lys Asn Lys Lys Lys Gly 165 170 175 Lys Lys Ala Gly Pro Pro Gly
Pro Asn Gly Pro Pro Gly Pro Pro Gly 180 185 190 Pro Pro Gly Pro Gln
Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 195 200 205 Pro Gly Thr
Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 210 215 220 Pro
Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 225 230
235 240 Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly
Gln 245 250 255 Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly
Val Leu Asn 260 265 270 Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val
Phe Lys Leu His Pro 275 280 285 Arg Ser Gly Glu Leu Glu Val Leu Val
Asp Gly Thr Tyr Phe Ile Tyr 290 295 300 Ser Gln Val Glu Val Tyr Tyr
Ile Asn Phe Thr Asp Phe Ala Ser Tyr 305 310 315 320 Glu Val Val Val
Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile 325 330 335 Glu Thr
Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys 340 345 350
Leu Leu Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp 355
360 365 Ile Ser Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile
Arg 370 375 380 Leu Gly Glu Ala Pro Ala Ser 385 390 <210> SEQ
ID NO 20 <211> LENGTH: 389 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (245)..(389) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_001005609 <309> DATABASE ENTRY DATE: 2008-12-21
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(389) <400>
SEQUENCE: 20 Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro
Ala Ala Ala 1 5 10 15 Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys
Gly Gly Ala Pro Ala 20 25 30 Arg Ala Gly Glu Gly Asn Ser Cys Leu
Leu Phe Leu Gly Phe Phe Gly 35 40 45 Leu Ser Leu Ala Leu His Leu
Leu Thr Leu Cys Cys Tyr Leu Glu Leu 50 55 60 Arg Ser Glu Leu Arg
Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 65 70 75 80 Ser Gly Thr
Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 85 90 95 Asp
Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 100 105
110 Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln
115 120 125 Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp
Glu Lys 130 135 140 Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg
Asn Lys Arg Ser 145 150 155 160 Lys Ser Asn Glu Gly Ala Asp Gly Pro
Val Lys Asn Lys Lys Lys Gly 165 170 175 Lys Lys Ala Gly Pro Pro Gly
Pro Asn Gly Pro Pro Gly Pro Pro Gly 180 185 190 Pro Pro Gly Pro Gln
Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 195 200 205 Pro Gly Thr
Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 210 215 220 Pro
Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 225 230
235 240 Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly
Gln 245 250 255 Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly
Val Leu Asn 260 265 270 Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val
Phe Lys Leu His Pro 275 280 285 Arg Ser Gly Glu Leu Glu Val Leu Val
Asp Gly Thr Tyr Phe Ile Tyr 290 295 300 Ser Gln Val Tyr Tyr Ile Asn
Phe Thr Asp Phe Ala Ser Tyr Glu Val 305 310 315 320 Val Val Asp Glu
Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr 325 330 335 Gly Lys
Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu 340 345 350
Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser 355
360 365 Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu
Gly 370 375 380 Glu Ala Pro Ala Ser 385 <210> SEQ ID NO 21
<211> LENGTH: 375 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (217)..(375) <223> OTHER INFORMATION:
Preferred collectin trimerization domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (217)..(257)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(218)..(375) <223> OTHER INFORMATION: Preferred collectin
trimerization domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (218)..(257) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (219)..(375) <223>
OTHER INFORMATION: Preferred collectin trimerization domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (219)..(257) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (220)..(375) <223> OTHER INFORMATION:
Preferred collectin trimerization domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (220)..(257)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(221)..(375) <223> OTHER INFORMATION: Preferred collectin
trimerization domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (221)..(257) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (222)..(375) <223>
OTHER INFORMATION: Preferred collectin trimerization domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (222)..(257) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (223)..(375) <223> OTHER INFORMATION:
Preferred collectin trimerization domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (223)..(257)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(224)..(375) <223> OTHER INFORMATION: Preferred collectin
trimerization domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (224)..(257) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (225)..(375) <223>
OTHER INFORMATION: Preferred collectin trimerization domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (225)..(257) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (258)..(375) <223> OTHER INFORMATION:
Preferred carbohydrate recognition domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: P35247
<309> DATABASE ENTRY DATE: 2008-12-16 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(375) <400> SEQUENCE: 21 Met Leu
Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 1 5 10 15
Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 20
25 30 Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu
Pro 35 40 45 Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg Gly
Glu Lys Gly 50 55 60 Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala
Gly Met Pro Gly Gln 65 70 75 80 Ala Gly Pro Val Gly Pro Lys Gly Asp
Asn Gly Ser Val Gly Glu Pro 85 90 95 Gly Pro Lys Gly Asp Thr Gly
Pro Ser Gly Pro Pro Gly Pro Pro Gly 100 105 110 Val Pro Gly Pro Ala
Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn 115 120 125 Ile Gly Pro
Gln Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys 130 135 140 Gly
Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 145 150
155 160 Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly
Val 165 170 175 Pro Gly Asn Ala Gly Ala Ala Gly Ser Ala Gly Ala Met
Gly Pro Gln 180 185 190 Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu
Lys Gly Asp Lys Gly 195 200 205 Ile Pro Gly Asp Lys Gly Ala Lys Gly
Glu Ser Gly Leu Pro Asp Val 210 215 220 Ala Ser Leu Arg Gln Gln Val
Glu Ala Leu Gln Gly Gln Val Gln His 225 230 235 240 Leu Gln Ala Ala
Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 245 250 255 Gly Gln
Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 260 265 270
Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 275
280 285 Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu
Val 290 295 300 Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp
Ser Lys Thr 305 310 315 320 Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu
Ser Leu Val Tyr Ser Asn 325 330 335 Trp Ala Pro Gly Glu Pro Asn Asp
Asp Gly Gly Ser Glu Asp Cys Val 340 345 350 Glu Ile Phe Thr Asn Gly
Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 355 360 365 Arg Leu Val Val
Cys Glu Phe 370 375 <210> SEQ ID NO 22 <211> LENGTH:
271 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (110)..(147) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (110)..(148) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (110)..(149) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (110)..(150) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (110)..(151)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(116)..(147) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (116)..(148) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (116)..(149) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (116)..(150) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (116)..(151) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (121)..(147)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(121)..(148) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (121)..(149) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (121)..(150) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (121)..(151) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (149)..(271) <223>
OTHER INFORMATION: Preferred carbohydrate recognition domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (152)..(271) <223> OTHER INFORMATION: Preferred
carbohydrate recognition domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: Q9BWP8
<309> DATABASE ENTRY DATE: 2008-12-16 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(271) <400> SEQUENCE: 22 Met Arg
Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 1 5 10 15
Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 20
25 30 Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly
Glu 35 40 45 Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val
Gly Pro Thr 50 55 60 Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln
Lys Gly Ser Val Gly 65 70 75 80 Arg His Gly Lys Ile Gly Pro Ile Gly
Ser Lys Gly Glu Lys Gly Asp 85 90 95 Ser Gly Asp Ile Gly Pro Pro
Gly Pro Asn Gly Glu Pro Gly Leu Pro 100 105 110 Cys Glu Cys Ser Gln
Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 115 120 125 Val Ser Gln
Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 130 135 140 Gly
Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 145 150
155 160 Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly
Thr 165 170 175 Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met
Ala Ala Tyr 180 185 190 Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile
Gly Ile Asn Asp Leu 195 200 205 Glu Lys Glu Gly Ala Phe Val Tyr Ser
Asp His Ser Pro Met Arg Thr 210 215 220 Phe Asn Lys Trp Arg Ser Gly
Glu Pro Asn Asn Ala Tyr Asp Glu Glu 225 230 235 240 Asp Cys Val Glu
Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 245 250 255 His Thr
Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 260 265 270
<210> SEQ ID NO 23 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Signal peptide <400> SEQUENCE:
23 Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly
1 5 10 15 Val Gln Cys <210> SEQ ID NO 24 <211> LENGTH:
20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Signal peptide
<400> SEQUENCE: 24 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly 20 <210>
SEQ ID NO 25 <211> LENGTH: 20 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Signal peptide <400> SEQUENCE:
25 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
1 5 10 15 Ala Gly Asn Gly 20 <210> SEQ ID NO 26 <211>
LENGTH: 339 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(182)
<223> OTHER INFORMATION: TRAIL receptor binding domain
(residues 120-281 of SEQ ID NO:10) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (183)..(339)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 219-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (183)..(221)
<223> OTHER INFORMATION: SP-D neck region (residues 219-257
of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (222)..(339) <223> OTHER
INFORMATION: SP-D CRD (residues 258-375 of SEQ ID NO:21)
<400> SEQUENCE: 26 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala
Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser
Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile
Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80
Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85
90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile
Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys
Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly
Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu
Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu
Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu
Val Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 180 185 190 Gln Gln
Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 195 200 205
Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 210
215 220 Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr
Glu 225 230 235 240 Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu
Ala Ser Pro Arg 245 250 255 Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln
Leu Val Val Ala Lys Asn 260 265 270 Glu Ala Ala Phe Leu Ser Met Thr
Asp Ser Lys Thr Glu Gly Lys Phe 275 280 285 Thr Tyr Pro Thr Gly Glu
Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 290 295 300 Glu Pro Asn Asp
Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 305 310 315 320 Asn
Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 325 330
335 Cys Glu Phe <210> SEQ ID NO 27 <211> LENGTH: 343
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide 2
(SEQ ID NO:24) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(186) <223> OTHER
INFORMATION: TRAIL receptor binding domain (residues 116-281 of SEQ
ID NO:10) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (187)..(343) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 219-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (187)..(225) <223> OTHER INFORMATION:
SP-D neck region (residues 219-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(226)..(343) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <400> SEQUENCE: 27 Met Glu Thr Asp
Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser
Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 20 25 30
Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 35
40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg
Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly
Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser
Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu Asn Thr
Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys Tyr Thr
Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala Arg Asn
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr Ser Ile
Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150 155 160
Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 165
170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Gly Leu Pro Asp
Val 180 185 190 Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln
Val Gln His 195 200 205 Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val
Glu Leu Phe Pro Asn 210 215 220 Gly Gln Ser Val Gly Glu Lys Ile Phe
Lys Thr Ala Gly Phe Val Lys 225 230 235 240 Pro Phe Thr Glu Ala Gln
Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 245 250 255 Ala Ser Pro Arg
Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val 260 265 270 Val Ala
Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 275 280 285
Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 290
295 300 Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys
Val 305 310 315 320 Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala
Cys Gly Glu Lys 325 330 335 Arg Leu Val Val Cys Glu Phe 340
<210> SEQ ID NO 28 <211> LENGTH: 225 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(186) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 116-281 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(225) <223> OTHER INFORMATION: SP-D neck region
(residues 219-257 of SEQ ID NO:21) <400> SEQUENCE: 28 Met Glu
Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15
Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 20
25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys
Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser
Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His Leu Arg
Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile
Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu
Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys
Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr
Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150
155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His
Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Gly Leu
Pro Asp Val 180 185 190 Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
Gly Gln Val Gln His 195 200 205 Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val Glu Leu Phe Pro Asn 210 215 220 Gly 225 <210> SEQ ID
NO 29 <211> LENGTH: 338 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(182) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 120-281 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(183)..(338) <223> OTHER INFORMATION: Collectin-11 collectin
trimerization domain (residues 116-271 of SEQ ID NO:22) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(183)..(218) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 116-151 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(219)..(338) <223> OTHER INFORMATION: Collectin-11 CRD
(residues 152-271 of SEQ ID NO:22) <400> SEQUENCE: 29 Met Glu
Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15
Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20
25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala
Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly
His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu
Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr
Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn
Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr
Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys
Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln
Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150
155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe
Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Gln Leu Arg Lys Ala Ile
Gly Glu Met 180 185 190 Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu
Lys Phe Ile Lys Asn 195 200 205 Ala Val Ala Gly Val Arg Glu Thr Glu
Ser Lys Ile Tyr Leu Leu Val 210 215 220 Lys Glu Glu Lys Arg Tyr Ala
Asp Ala Gln Leu Ser Cys Gln Gly Arg 225 230 235 240 Gly Gly Thr Leu
Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met 245 250 255 Ala Ala
Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile 260 265 270
Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro 275
280 285 Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala
Tyr 290 295 300 Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser Gly Gly
Trp Asn Asp 305 310 315 320 Val Ala Cys His Thr Thr Met Tyr Phe Met
Cys Glu Phe Asp Lys Glu 325 330 335 Asn Met <210> SEQ ID NO
30 <211> LENGTH: 342 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(186) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 116-281 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(342) <223> OTHER INFORMATION: Collectin-11 collectin
trimerization domain (residues 116-271 of SEQ ID NO:22) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(222) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 116-151 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(223)..(342) <223> OTHER INFORMATION: Collectin-11 CRD
(residues 152-271 of SEQ ID NO:22) <400> SEQUENCE: 30 Met Glu
Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15
Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 20
25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys
Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser
Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His Leu Arg
Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile
Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu
Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys
Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr
Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150
155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His
Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Gln Leu
Arg Lys Ala 180 185 190 Ile Gly Glu Met Asp Asn Gln Val Ser Gln Leu
Thr Ser Glu Leu Lys 195 200 205 Phe Ile Lys Asn Ala Val Ala Gly Val
Arg Glu Thr Glu Ser Lys Ile 210 215 220 Tyr Leu Leu Val Lys Glu Glu
Lys Arg Tyr Ala Asp Ala Gln Leu Ser 225 230 235 240 Cys Gln Gly Arg
Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala Ala 245 250 255 Asn Gly
Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val 260 265 270
Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr Ser 275
280 285 Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu
Pro 290 295 300 Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val
Ala Ser Gly 305 310 315 320 Gly Trp Asn Asp Val Ala Cys His Thr Thr
Met Tyr Phe Met Cys Glu 325 330 335 Phe Asp Lys Glu Asn Met 340
<210> SEQ ID NO 31 <211> LENGTH: 222 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(186) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 116-281 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(222) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 116-151 of SEQ ID NO:22) <400> SEQUENCE: 31
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile
Thr 20 25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn
Ser Lys Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp
Glu Ser Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His
Leu Arg Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr
Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile
Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile
Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys
Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135
140 Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg
145 150 155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met
Asp His Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser
Gln Leu Arg Lys Ala 180 185 190 Ile Gly Glu Met Asp Asn Gln Val Ser
Gln Leu Thr Ser Glu Leu Lys 195 200 205 Phe Ile Lys Asn Ala Val Ala
Gly Val Arg Glu Thr Glu Ser 210 215 220 <210> SEQ ID NO 32
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Flag-epitope/enterokinase processing site <400>
SEQUENCE: 32 Asp Tyr Lys Asp Asp Asp Asp Lys Asp 1 5 <210>
SEQ ID NO 33 <211> LENGTH: 54 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(1)..(1) <223> OTHER INFORMATION: Gly (when a=1, 2, 3, 4, 5,
or 6) or absent (when a=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (2)..(2) <223>
OTHER INFORMATION: Ser (when a=1, 2, 3, 4, 5, or 6) or absent (when
a=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Ser
(when a=1, 2, 3, 4, 5, or 6) or absent (when a=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(4)..(4) <223> OTHER INFORMATION: Gly (when a=2, 3, 4, 5, or
6) or absent (when a=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (5)..(5) <223>
OTHER INFORMATION: Ser (when a=2, 3, 4, 5, or 6) or absent (when
a=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (6)..(6) <223> OTHER INFORMATION: Ser
(when a=2, 3, 4, 5, or 6) or absent (when a=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(7)..(7) <223> OTHER INFORMATION: Gly (when a=3, 4, 5, or 6)
or absent (when a=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (8)..(8) <223>
OTHER INFORMATION: Ser (when a=3, 4, 5, or 6) or absent (when a=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (9)..(9) <223> OTHER INFORMATION: Ser
(when a=3, 4, 5, or 6) or absent (when a=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: Gly (when a=4, 5, or 6)
or absent (when a=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Ser (when a=4, 5, or 6) or absent (when a=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (12)..(12) <223> OTHER INFORMATION: Ser
(when a=4, 5, or 6) or absent (when a=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Gly (when a=5 or 6) or
absent (when a=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Ser (when a=5 or 6) or absent (when a=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Ser
(when a=5 or 6) or absent (when a=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Gly (when a=6) or absent
(when a=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (17)..(17) <223>
OTHER INFORMATION: Ser (when a=6) or absent (when a=0, 1, 2, 3, 4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Ser
(when a=6) or absent (when a=0, 1, 2, 3, 4, or 5) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Ser (when b=1, 2, 3, 4,
5, or 6) or absent (when b=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Ser (when b=1, 2, 3, 4, 5, or 6) or absent (when
b=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Gly
(when b=1, 2, 3, 4, 5, or 6) or absent (when b=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(22)..(22) <223> OTHER INFORMATION: Ser (when b=2, 3, 4, 5,
or 6) or absent (when b=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (23)..(23) <223>
OTHER INFORMATION: Ser (when b=2, 3, 4, 5, or 6) or absent (when
b=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: Gly
(when b=2, 3, 4, 5, or 6) or absent (when b=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(25)..(25) <223> OTHER INFORMATION: Ser (when b=3, 4, 5, or
6) or absent (when b=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (26)..(26) <223>
OTHER INFORMATION: Ser (when b=3, 4, 5, or 6) or absent (when b=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Gly
(when b=3, 4, 5, or 6) or absent (when b=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(28)..(28) <223> OTHER INFORMATION: Ser (when b=4, 5, or 6)
or absent (when b=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29) <223>
OTHER INFORMATION: Ser (when b=4, 5, or 6) or absent (when b=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (30)..(30) <223> OTHER INFORMATION: Gly
(when b=4, 5, or 6) or absent (when b=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(31)..(31) <223> OTHER INFORMATION: Ser (when b=5 or 6) or
absent (when b=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (32)..(32) <223>
OTHER INFORMATION: Ser (when b=5 or 6) or absent (when b=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (33)..(33) <223> OTHER INFORMATION: Gly
(when b=5 or 6) or absent (when b=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(34)..(34) <223> OTHER INFORMATION: Ser (when b=6) or absent
(when b=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (35)..(35) <223>
OTHER INFORMATION: Ser (when b=6) or absent (when b=0, 1, 2, 3, 4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (36)..(36) <223> OTHER INFORMATION: Gly
(when b=6) or absent (when b=0, 1, 2, 3, 4, or 5) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(37)..(37) <223> OTHER INFORMATION: Gly (when c=1, 2, 3, 4,
5, or 6) or absent (when c=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (38)..(38) <223>
OTHER INFORMATION: Ser (when c=1, 2, 3, 4, 5, or 6) or absent (when
c=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION: Gly
(when c=1, 2, 3, 4, 5, or 6) or absent (when c=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Gly (when c=2, 3, 4, 5,
or 6) or absent (when c=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: Ser (when c=2, 3, 4, 5, or 6) or absent (when
c=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (42)..(42) <223> OTHER INFORMATION: Gly
(when c=2, 3, 4, 5, or 6) or absent (when c=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(43)..(43) <223> OTHER INFORMATION: Gly (when c=3, 4, 5, or
6) or absent (when c=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (44)..(44) <223>
OTHER INFORMATION: Ser (when c=3, 4, 5, or 6) or absent (when c=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (45)..(45) <223> OTHER INFORMATION: Gly
(when c=3, 4, 5, or 6) or absent (when c=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(46)..(46) <223> OTHER INFORMATION: Gly (when c=4, 5, or 6)
or absent (when c=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (47)..(47) <223>
OTHER INFORMATION: Ser (when c=4, 5, or 6) or absent (when c=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (48)..(48) <223> OTHER INFORMATION: Gly
(when c=4, 5, or 6) or absent (when c=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(49)..(49) <223> OTHER INFORMATION: Gly (when c=5 or 6) or
absent (when c=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (50)..(50) <223>
OTHER INFORMATION: Ser (when c=5 or 6) or absent (when c=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (51)..(51) <223> OTHER INFORMATION: Gly
(when c=5 or 6) or absent (when c=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(52)..(52) <223> OTHER INFORMATION: Gly (when c=6) or absent
(when c=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (53)..(53) <223>
OTHER INFORMATION: Ser (when c=6) or absent (when c=0, 1, 2, 3, 4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (54)..(54) <223> OTHER INFORMATION: Gly
(when c=6) or absent (when c=0, 1, 2, 3, 4, or 5) <400>
SEQUENCE: 33 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Xaa Xaa Xaa Xaa Xaa Xaa 50
<210> SEQ ID NO 34 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <400>
SEQUENCE: 34 Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 1 5 10
<210> SEQ ID NO 35 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <400>
SEQUENCE: 35 Gly Ser Ser Gly Ser Ser Gly Ser 1 5 <210> SEQ ID
NO 36 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Flexible linker element <400> SEQUENCE: 36
Gly Ser Ser Gly Ser 1 5 <210> SEQ ID NO 37 <211>
LENGTH: 825 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <300> PUBLICATION INFORMATION: <308> DATABASE
ACCESSION NUMBER: P24394 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(825)
<400> SEQUENCE: 37 Met Gly Trp Leu Cys Ser Gly Leu Leu Phe
Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly
Asn Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr
Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Asn Gly Pro Thr
Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe
Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 65 70 75 80
Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 85
90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp
Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala
Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Leu
Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu
Tyr Asn His Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu
Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 165 170 175 Val Thr Tyr Leu
Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 180 185 190 Ser Gly
Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 195 200 205
Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 210
215 220 Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val
Ser 225 230 235 240 Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr
Val Ser Ile Thr 245 250 255 Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile
Pro Asn Pro Ala Arg Ser 260 265 270 Arg Leu Val Ala Ile Ile Ile Gln
Asp Ala Gln Gly Ser Gln Trp Glu 275 280 285 Lys Arg Ser Arg Gly Gln
Glu Pro Ala Lys Cys Pro His Trp Lys Asn 290 295 300 Cys Leu Thr Lys
Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 305 310 315 320 Asp
Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 325 330
335 Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp
340 345 350 Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu
Ala Pro 355 360 365 Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu
Lys Gly Ser Phe 370 375 380 Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp
Phe Gln Glu Gly Arg Glu 385 390 395 400 Gly Ile Val Ala Arg Leu Thr
Glu Ser Leu Phe Leu Asp Leu Leu Gly 405 410 415 Glu Glu Asn Gly Gly
Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 420 425 430 Leu Pro Pro
Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 435 440 445 Pro
Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 450 455
460 Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp
465 470 475 480 Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly
Asn Pro Ala 485 490 495 Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser
Pro Cys Pro Arg Glu 500 505 510 Leu Gly Pro Asp Pro Leu Leu Ala Arg
His Leu Glu Glu Val Glu Pro 515 520 525 Glu Met Pro Cys Val Pro Gln
Leu Ser Glu Pro Thr Thr Val Pro Gln 530 535 540 Pro Glu Pro Glu Thr
Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 545 550 555 560 His Gly
Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 565 570 575
Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 580
585 590 Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser
Ser 595 600 605 Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly
Phe Gly Ala 610 615 620 Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln
Asp Leu Ile Pro Gly 625 630 635 640 Cys Pro Gly Asp Pro Ala Pro Val
Pro Val Pro Leu Phe Thr Phe Gly 645 650 655 Leu Asp Arg Glu Pro Pro
Arg Ser Pro Gln Ser Ser His Leu Pro Ser 660 665 670 Ser Ser Pro Glu
His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 675 680 685 Met Pro
Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 690 695 700
Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 705
710 715 720 Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly
Gln Thr 725 730 735 Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys
Gly Asp Arg Ser 740 745 750 Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro
Asp Pro Ser Pro Gly Gly 755 760 765 Val Pro Leu Glu Ala Ser Leu Cys
Pro Ala Ser Leu Ala Pro Ser Gly 770 775 780 Ile Ser Glu Lys Ser Lys
Ser Ser Ser Ser Phe His Pro Ala Pro Gly 785 790 795 800 Asn Ala Gln
Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 805 810 815 Val
Gly Pro Thr Tyr Met Arg Val Ser 820 825 <210> SEQ ID NO 38
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Strep-tag II <400> SEQUENCE: 38 Trp Ser His Pro
Gln Phe Glu Lys 1 5 <210> SEQ ID NO 39 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Affinity tag
linker element <400> SEQUENCE: 39 Pro Ser Ser Ser Ser Ser Ser
Ala 1 5 <210> SEQ ID NO 40 <211> LENGTH: 346
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide
(SEQ ID NO:24) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(160) <223> OTHER
INFORMATION: CD95L receptor binding domain (residues 142-281 of SEQ
ID NO:6) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (161)..(171) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (172)..(327)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 220-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (172)..(209)
<223> OTHER INFORMATION: SP-D neck region (residues 220-257
of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (210)..(327) <223> OTHER
INFORMATION: SP-D CRD (residues 258-375 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (328)..(338) <223> OTHER INFORMATION: Affinity tag
linker element (SEQ ID NO:54) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (339)..(346)
<223> OTHER INFORMATION: Strep-tag II (SEQ ID NO:38)
<400> SEQUENCE: 40 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu Leu Arg Lys
Val Ala His Leu Thr Gly Lys Ser 20 25 30 Asn Ser Arg Ser Met Pro
Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val 35 40 45 Leu Leu Ser Gly
Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu 50 55 60 Thr Gly
Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser 65 70 75 80
Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys 85
90 95 Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr
Cys 100 105 110 Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Val Gly
Ala Val Phe 115 120 125 Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn
Val Ser Glu Leu Ser 130 135 140 Leu Val Asn Phe Glu Glu Ser Gln Thr
Phe Phe Gly Leu Tyr Lys Leu 145 150 155 160 Gly Ser Ser Gly Ser Ser
Gly Ser Ser Gly Ser Gly Leu Pro Asp Val 165 170 175 Ala Ser Leu Arg
Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 180 185 190 Leu Gln
Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 195 200 205
Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 210
215 220 Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln
Leu 225 230 235 240 Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu
Gln Gln Leu Val 245 250 255 Val Ala Lys Asn Glu Ala Ala Phe Leu Ser
Met Thr Asp Ser Lys Thr 260 265 270 Glu Gly Lys Phe Thr Tyr Pro Thr
Gly Glu Ser Leu Val Tyr Ser Asn 275 280 285 Trp Ala Pro Gly Glu Pro
Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 290 295 300 Glu Ile Phe Thr
Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 305 310 315 320 Arg
Leu Val Val Cys Glu Phe Gly Gly Ser Pro Ser Ser Ser Ser Ser 325 330
335 Ser Ala Trp Ser His Pro Gln Phe Glu Lys 340 345 <210> SEQ
ID NO 41 <211> LENGTH: 356 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(170) <223> OTHER INFORMATION: LIGHT receptor binding
domain (residues 91-240 of SEQ ID NO:16) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(171)..(181) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (182)..(337) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 220-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (182)..(219) <223> OTHER INFORMATION:
SP-D neck region (residues 220-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(220)..(337) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (338)..(348) <223> OTHER
INFORMATION: Affinity tag linker element 2 (SEQ ID NO:54)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (349)..(356) <223> OTHER INFORMATION: Strep-tag II
(SEQ ID NO:38) <400> SEQUENCE: 41 Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu
Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 20 25 30 Ser Ser Leu
Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 35 40 45 Gly
Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 50 55
60 Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly
65 70 75 80 Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His
Gly Leu 85 90 95 Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu
Leu Leu Val Ser 100 105 110 Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser
Ser Ser Arg Val Trp Trp 115 120 125 Asp Ser Ser Phe Leu Gly Gly Val
Val His Leu Glu Ala Gly Glu Glu 130 135 140 Val Val Val Arg Val Leu
Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 145 150 155 160 Thr Arg Ser
Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Gly Ser Ser 165 170 175 Gly
Ser Ser Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln 180 185
190 Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser
195 200 205 Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val
Gly Glu 210 215 220 Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe
Thr Glu Ala Gln 225 230 235 240 Leu Leu Cys Thr Gln Ala Gly Gly Gln
Leu Ala Ser Pro Arg Ser Ala 245 250 255 Ala Glu Asn Ala Ala Leu Gln
Gln Leu Val Val Ala Lys Asn Glu Ala 260 265 270 Ala Phe Leu Ser Met
Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr 275 280 285 Pro Thr Gly
Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro 290 295 300 Asn
Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly 305 310
315 320 Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val Cys
Glu 325 330 335 Phe Gly Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala Trp
Ser His Pro 340 345 350 Gln Phe Glu Lys 355 <210> SEQ ID NO
42 <211> LENGTH: 1129 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Expression cassette for TRAIL-SPD fusion protein
3 (SEQ ID NO:43) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(6) <223> OTHER
INFORMATION: HindIII restriction site <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (16)..(18)
<223> OTHER INFORMATION: Start codon <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(559)..(564) <223> OTHER INFORMATION: BamHI restriction site
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1122)..(1129) <223> OTHER INFORMATION: NotI
restriction site <400> SEQUENCE: 42 aagcttgccg ccaccatgga
gaccgataca ctgctcttgt gggtgctctt gctgtgggtt 60 cctgcaggta
atggtcaaag agtcgcagct cacatcactg ggactagagg caggagtaac 120
accctgagtt ctcccaattc caagaacgag aaagccctgg gtaggaagat caactcctgg
180 gaaagctcca gaagcggcca tagctttctt agcaacctcc acttgaggaa
tggcgaactt 240 gtgatccatg agaagggctt ctactacatc tacagccaga
cgtacttcag gttccaggag 300 gaaatcaagg agaacaccaa gaacgacaag
cagatggtgc aatacatcta caagtacacg 360 tcataccctg atcctatact
gctgatgaag tccgccagaa acagttgctg gagcaaagac 420 gctgaatacg
gcctgtattc catctatcag ggcggtatct ttgaactcaa ggagaacgac 480
aggatcttcg tgtctgtgac aaacgagcat ctgatcgaca tggaccatga agcgtctttc
540 ttcggtgcct tcttggtggg atcctctggt tcgagtggtt cgagtggttc
tggattgcca 600 gacgttgctt ctttgagaca acaggttgag gctttgcagg
gtcaagtcca gcacttgcag 660 gctgctttct ctcaatacaa gaaggttgag
ttgttcccaa acggtcaatc tgttggcgaa 720 aagattttca agactgctgg
tttcgtcaaa ccattcacgg aggcacaatt attgtgtact 780 caggctggtg
gacagttggc ctctccacgt tctgccgctg agaacgccgc cttgcaacag 840
ttggtcgtag ctaagaacga ggctgctttc ttgagcatga ctgattccaa gacagagggc
900 aagttcacct acccaacagg agaatccttg gtctattcta attgggcacc
tggagagccc 960 aacgatgatg gcggctcaga ggactgtgtg gaaatcttca
ccaatggcaa gtggaatgac 1020 agagcttgtg gagagaagcg tttggtggtc
tgtgagttcg gaggcagtcc ttcatcttca 1080 tctagctctg cctggtcgca
tccacaattc gagaaataat agcggccgc 1129 <210> SEQ ID NO 43
<211> LENGTH: 367 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(181) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 120-280 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(348) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 220-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(230) <223> OTHER INFORMATION:
SP-D neck region (residues 220-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(231)..(348) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (349)..(359) <223> OTHER
INFORMATION: Affinity tag linker element 2 (SEQ ID NO:54)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (360)..(367) <223> OTHER INFORMATION: Strep-tag II
(SEQ ID NO:38) <400> SEQUENCE: 43 Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn
Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly
Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55
60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys
65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln
Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val
Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu
Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn
Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly
Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185
190 Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
195 200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val 210 215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys
Ile Phe Lys Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu
Ala Gln Leu Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser
Pro Arg Ser Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val
Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser
Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu
Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310
315 320 Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp
Arg 325 330 335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly
Gly Ser Pro 340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro
Gln Phe Glu Lys 355 360 365 <210> SEQ ID NO 44 <211>
LENGTH: 246 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(181)
<223> OTHER INFORMATION: TRAIL receptor binding domain
(residues 120-280 of SEQ ID NO:10) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (182)..(192)
<223> OTHER INFORMATION: Flexible linker A (SEQ ID NO:34)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (193)..(230) <223> OTHER INFORMATION: SP-D neck
region (residues 220-257 of SEQ ID NO:21) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(231)..(238) <223> OTHER INFORMATION: Affinity tag linker
element (SEQ ID NO:39) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (239)..(246) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg
Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu
Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg
Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly
Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser
Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr
Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135
140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser
145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala
Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser Ser
Gly Ser Ser Gly Ser 180 185 190 Gly Leu Pro Asp Val Ala Ser Leu Arg
Gln Gln Val Glu Ala Leu Gln 195 200 205 Gly Gln Val Gln His Leu Gln
Ala Ala Phe Ser Gln Tyr Lys Lys Val 210 215 220 Glu Leu Phe Pro Asn
Gly Pro Ser Ser Ser Ser Ser Ser Ala Trp Ser 225 230 235 240 His Pro
Gln Phe Glu Lys 245 <210> SEQ ID NO 45 <211> LENGTH:
365 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide 3
(SEQ ID NO:25) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(181) <223> OTHER
INFORMATION: TRAIL receptor binding domain (residues 120-280 of SEQ
ID NO:10) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (182)..(192) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (193)..(347)
<223> OTHER INFORMATION: Collectin-11 colletin trimerization
domain (residues 117-271 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(193)..(224) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 117-148 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(225)..(347) <223> OTHER INFORMATION: Collectin-11 CRD
(residues 149-271 of SEQ ID NO:22) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (348)..(357)
<223> OTHER INFORMATION: Affinity tag linker element 3 (SEQ
ID NO:55) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (358)..(365) <223> OTHER INFORMATION:
Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 45 Met Glu Thr
Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala
Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25
30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu
35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His
Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val
Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr
Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp
Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro
Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp
Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly
Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155
160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe
165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser
Gly Ser 180 185 190 Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln
Val Ser Gln Leu 195 200 205 Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala
Val Ala Gly Val Arg Glu 210 215 220 Thr Glu Ser Lys Ile Tyr Leu Leu
Val Lys Glu Glu Lys Arg Tyr Ala 225 230 235 240 Asp Ala Gln Leu Ser
Cys Gln Gly Arg Gly Gly Thr Leu Ser Met Pro 245 250 255 Lys Asp Glu
Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala 260 265 270 Gly
Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly 275 280
285 Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp
290 295 300 Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys
Val Glu 305 310 315 320 Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala
Cys His Thr Thr Met 325 330 335 Tyr Phe Met Cys Glu Phe Asp Lys Glu
Asn Met Gly Ser Pro Ser Ser 340 345 350 Ser Ser Ser Ser Ala Trp Ser
His Pro Gln Phe Glu Lys 355 360 365 <210> SEQ ID NO 46
<211> LENGTH: 246 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(181) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 120-280 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(193) <223> OTHER INFORMATION: Flexible linker E (SEQ
ID NO:56) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (194)..(229) <223> OTHER INFORMATION:
Collectin-11 neck region (residues 116-151 of SEQ ID NO:22)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (230)..(238) <223> OTHER INFORMATION: Affinity tag
linker element 4 (SEQ ID NO:57) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (239)..(246)
<223> OTHER INFORMATION: Strep-tag II (SEQ ID NO:38)
<400> SEQUENCE: 46 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala
Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser
Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile
Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80
Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85
90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile
Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys
Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly
Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu
Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu
Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu
Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185 190 Gly Ser
Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 195 200 205
Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val 210
215 220 Arg Glu Thr Glu Ser Gly Pro Ser Ser Ser Ser Ser Ser Ala Trp
Ser 225 230 235 240 His Pro Gln Phe Glu Lys 245 <210> SEQ ID
NO 47 <211> LENGTH: 367 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(181) <223> OTHER INFORMATION: TRAIL mutant 1 receptor
binding domain (residues 120-280 of SEQ ID NO:10 with Y189A, Q193S,
N199V, K201R, Y213W, S215D) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (182)..(192)
<223> OTHER INFORMATION: Flexible linker A (SEQ ID NO:34)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (193)..(348) <223> OTHER INFORMATION: SP-D
collectin trimerization domain (residues 220-375 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (193)..(230) <223> OTHER INFORMATION: SP-D neck
region (residues 220-257 of SEQ ID NO:21) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(231)..(348) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (349)..(359) <223> OTHER
INFORMATION: Affinity tag linker element 2 (SEQ ID NO:54)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (360)..(367) <223> OTHER INFORMATION: Strep-tag II
(SEQ ID NO:38) <400> SEQUENCE: 47 Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn
Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly
Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55
60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys
65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Ala Phe Arg Phe Ser
Glu Glu 85 90 95 Ile Lys Glu Val Thr Arg Asn Asp Lys Gln Met Val
Gln Tyr Ile Tyr 100 105 110 Lys Trp Thr Asp Tyr Pro Asp Pro Ile Leu
Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn
Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly
Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185
190 Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
195 200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val 210 215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys
Ile Phe Lys Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu
Ala Gln Leu Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser
Pro Arg Ser Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val
Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser
Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu
Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310
315 320 Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp
Arg 325 330 335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly
Gly Ser Pro 340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro
Gln Phe Glu Lys 355 360 365 <210> SEQ ID NO 48 <211>
LENGTH: 367 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(181)
<223> OTHER INFORMATION: TRAIL mutant 2 receptor binding
domain (residues 120-280 of SEQ ID NO:10 with Y189Q, R191K, Q193R,
H264R, I266L, D267Q) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (182)..(192) <223> OTHER
INFORMATION: Flexible linker A (SEQ ID NO:34) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(193)..(348) <223> OTHER INFORMATION: SP-D collectin
trimerization domain (residues 220-375 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(193)..(230) <223> OTHER INFORMATION: SP-D neck region
(residues 220-257 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (231)..(348)
<223> OTHER INFORMATION: SP-D CRD (residues 258-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (349)..(359) <223> OTHER INFORMATION:
Affinity tag linker element 2 (SEQ ID NO:54) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(360)..(367) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 48 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val
Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu
Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70
75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Gln Phe Lys Phe Arg Glu
Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln
Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu
Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu
Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu
Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu
Arg Leu Leu Gln Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala
Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185 190
Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln 195
200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys
Val 210 215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys Ile
Phe Lys Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu Ala
Gln Leu Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser Pro
Arg Ser Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val Val
Ala Lys Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser Lys
Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu Val
Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310 315
320 Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg
325 330 335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly Gly
Ser Pro 340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln
Phe Glu Lys 355 360 365 <210> SEQ ID NO 49 <211>
LENGTH: 367 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(181)
<223> OTHER INFORMATION: TRAIL receptor binding domain
(residues 120-280 of SEQ ID NO:10) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (182)..(192)
<223> OTHER INFORMATION: Flexible linker A (SEQ ID NO:34)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (193)..(348) <223> OTHER INFORMATION: SP-D mutant 1
collectin trimerization domain (residues 220-375 of SEQ ID NO:21
with F355A) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(230) <223> OTHER INFORMATION:
SP-D mutant 1 neck region (residues 220-257 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (231)..(348) <223> OTHER INFORMATION: SP-D mutant 1
CRD (residues 258-375 of SEQ ID NO:21 with F355A) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(349)..(359) <223> OTHER INFORMATION: Affinity tag linker
element 2 (SEQ ID NO:54) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (360)..(367) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 49
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg
Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu
Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg
Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly
Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser
Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr
Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135
140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser
145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala
Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser Ser
Gly Ser Ser Gly Ser 180 185 190 Gly Leu Pro Asp Val Ala Ser Leu Arg
Gln Gln Val Glu Ala Leu Gln 195 200 205 Gly Gln Val Gln His Leu Gln
Ala Ala Phe Ser Gln Tyr Lys Lys Val 210 215 220 Glu Leu Phe Pro Asn
Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr 225 230 235 240 Ala Gly
Phe Val Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln 245 250 255
Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala 260
265 270 Leu Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe Leu Ser
Met 275 280 285 Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr
Gly Glu Ser 290 295 300 Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro
Asn Asp Asp Gly Gly 305 310 315 320 Ser Glu Asp Cys Val Glu Ile Ala
Thr Asn Gly Lys Trp Asn Asp Arg 325 330 335 Ala Cys Gly Glu Lys Arg
Leu Val Val Cys Glu Phe Gly Gly Ser Pro 340 345 350 Ser Ser Ser Ser
Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 355 360 365 <210>
SEQ ID NO 50 <211> LENGTH: 367 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(181) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 120-280 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(348) <223> OTHER INFORMATION:
SP-D mutant 2 collectin trimerization domain (residues 220-375 of
SEQ ID NO:21 with F355D) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (193)..(230) <223> OTHER
INFORMATION: SP-D mutant 2 neck region (residues 220-257 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (231)..(348) <223> OTHER INFORMATION:
SP-D mutant 2 CRD (residues 258-375 of SEQ ID NO:21 with F355D)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (349)..(359) <223> OTHER INFORMATION: Affinity tag
linker element 2 (SEQ ID NO:54) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (360)..(367)
<223> OTHER INFORMATION: Strep-tag II (SEQ ID NO:38)
<400> SEQUENCE: 50 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala
Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser
Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile
Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80
Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85
90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile
Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys
Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly
Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu
Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu
Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu
Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185 190 Gly Leu
Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln 195 200 205
Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val 210
215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys Ile Phe Lys
Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu Ala Gln Leu
Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser
Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val Val Ala Lys
Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser Lys Thr Glu
Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu Val Tyr Ser
Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310 315 320 Ser
Glu Asp Cys Val Glu Ile Asp Thr Asn Gly Lys Trp Asn Asp Arg 325 330
335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly Gly Ser Pro
340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu
Lys 355 360 365 <210> SEQ ID NO 51 <211> LENGTH: 344
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide 3
(SEQ ID NO:25) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(158) <223> OTHER
INFORMATION: APRIL version 2 receptor binding domain (residues
113-250 of SEQ ID NO:14) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (159)..(169) <223> OTHER
INFORMATION: Flexible linker A (SEQ ID NO:34) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(170)..(325) <223> OTHER INFORMATION: SP-D collectin
trimerization domain (residues 220-375 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(170)..(207) <223> OTHER INFORMATION: SP-D neck region
(residues 220-257 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (208)..(325)
<223> OTHER INFORMATION: SP-D CRD (residues 258-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (326)..(336) <223> OTHER INFORMATION:
Affinity tag linker element 2 (SEQ ID NO:54) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(337)..(344) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 51 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Lys Gln His
Ser Val Leu His Leu Val Pro Ile Asn 20 25 30 Ala Thr Ser Lys Asp
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 35 40 45 Ala Leu Arg
Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 50 55 60 Ile
Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 65 70
75 80 Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln
Gly 85 90 95 Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro
Ser His Pro 100 105 110 Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly
Val Phe His Leu His 115 120 125 Gln Gly Asp Ile Leu Ser Val Ile Ile
Pro Arg Ala Arg Ala Lys Leu 130 135 140 Asn Leu Ser Pro His Gly Thr
Phe Leu Gly Phe Val Lys Leu Gly Ser 145 150 155 160 Ser Gly Ser Ser
Gly Ser Ser Gly Ser Gly Leu Pro Asp Val Ala Ser 165 170 175 Leu Arg
Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln 180 185 190
Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln 195
200 205 Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro
Phe 210 215 220 Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln
Leu Ala Ser 225 230 235 240 Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu
Gln Gln Leu Val Val Ala 245 250 255 Lys Asn Glu Ala Ala Phe Leu Ser
Met Thr Asp Ser Lys Thr Glu Gly 260 265 270 Lys Phe Thr Tyr Pro Thr
Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala 275 280 285 Pro Gly Glu Pro
Asn Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile 290 295 300 Phe Thr
Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu 305 310 315
320 Val Val Cys Glu Phe Gly Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala
325 330 335 Trp Ser His Pro Gln Phe Glu Lys 340 <210> SEQ ID
NO 52 <211> LENGTH: 450 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(140) <223> OTHER INFORMATION: Variable domain heavy
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (141)..(155) <223> OTHER INFORMATION:
Flexible linker element F (SEQ ID NO:58) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(156)..(264) <223> OTHER INFORMATION: Variable domain light
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (265)..(275) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (276)..(431)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 220-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (432)..(441)
<223> OTHER INFORMATION: Affinity tag linker element 2 (SEQ
ID NO:54) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (442)..(450) <223> OTHER INFORMATION:
Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 52 Met Glu Thr
Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala
Gly Asn Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 20 25
30 Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
35 40 45 Phe Asn Thr Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly
Lys Gly 50 55 60 Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn
Asn Tyr Ala Thr 65 70 75 80 Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe
Thr Leu Ser Arg Asp Asp 85 90 95 Ser Lys Asn Thr Leu Tyr Leu Gln
Met Asn Ser Leu Lys Thr Glu Asp 100 105 110 Thr Ala Val Tyr Tyr Cys
Thr Arg Asp Arg Gly Trp Gly Ala Met Asp 115 120 125 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 130 135 140 Ser Gly
Gly Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr 145 150 155
160 Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
165 170 175 Thr Cys Ser Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn Trp
Tyr Gln 180 185 190 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
Tyr Thr Ser Ser 195 200 205 Leu His Ser Gly Val Pro Ser Arg Phe Ser
Gly Ser Gly Ser Gly Thr 210 215 220 Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro Glu Asp Phe Ala Thr 225 230 235 240 Tyr Tyr Cys Gln Gln
Phe Ser Asn Leu Pro Trp Thr Phe Gly Gly Gly 245 250 255 Thr Lys Leu
Glu Ile Lys Arg Thr Gly Ser Ser Gly Ser Ser Gly Ser 260 265 270 Ser
Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu 275 280
285 Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr
290 295 300 Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu
Lys Ile 305 310 315 320 Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr
Glu Ala Gln Leu Leu 325 330 335 Cys Thr Gln Ala Gly Gly Gln Leu Ala
Ser Pro Arg Ser Ala Ala Glu 340 345 350 Asn Ala Ala Leu Gln Gln Leu
Val Val Ala Lys Asn Glu Ala Ala Phe 355 360 365 Leu Ser Met Thr Asp
Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr 370 375 380 Gly Glu Ser
Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp 385 390 395 400
Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp 405
410 415 Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe
Gly 420 425 430 Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala Trp Ser His
Pro Gln Phe 435 440 445 Glu Lys 450 <210> SEQ ID NO 53
<211> LENGTH: 450 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(140) <223> OTHER INFORMATION: Variable domain heavy
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (141)..(155) <223> OTHER INFORMATION:
Flexible linker element F (SEQ ID NO:58) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(156)..(264) <223> OTHER INFORMATION: Variable domain light
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (265)..(275) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (276)..(431)
<223> OTHER INFORMATION: SP-D mutant collectin trimerization
domain (residues 220-375 of SEQ ID NO:21 with F355D) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(432)..(441) <223> OTHER INFORMATION: Affinity tag linker
element (SEQ ID NO:54) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (442)..(450) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 53
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val 20 25 30 Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr 35 40 45 Phe Asn Thr Asn Ala Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly 50 55 60 Leu Glu Trp Val Ala Arg Ile Arg Ser
Lys Ser Asn Asn Tyr Ala Thr 65 70 75 80 Tyr Tyr Ala Asp Ser Val Lys
Asp Arg Phe Thr Leu Ser Arg Asp Asp 85 90 95 Ser Lys Asn Thr Leu
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 100 105 110 Thr Ala Val
Tyr Tyr Cys Thr Arg Asp Arg Gly Trp Gly Ala Met Asp 115 120 125 Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 130 135
140 Ser Gly Gly Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr
145 150 155 160 Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
Val Thr Ile 165 170 175 Thr Cys Ser Ala Ser Gln Asp Ile Asn Asn Tyr
Leu Asn Trp Tyr Gln 180 185 190 Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile Tyr Tyr Thr Ser Ser 195 200 205 Leu His Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr 210 215 220 Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 225 230 235 240 Tyr Tyr
Cys Gln Gln Phe Ser Asn Leu Pro Trp Thr Phe Gly Gly Gly 245 250 255
Thr Lys Leu Glu Ile Lys Arg Thr Gly Ser Ser Gly Ser Ser Gly Ser 260
265 270 Ser Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val
Glu 275 280 285 Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe
Ser Gln Tyr 290 295 300 Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser
Val Gly Glu Lys Ile 305 310 315 320 Phe Lys Thr Ala Gly Phe Val Lys
Pro Phe Thr Glu Ala Gln Leu Leu 325 330 335 Cys Thr Gln Ala Gly Gly
Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu 340 345 350 Asn Ala Ala Leu
Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe 355 360 365 Leu Ser
Met Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr 370 375 380
Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp 385
390 395 400 Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Asp Thr Asn Gly
Lys Trp 405 410 415 Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val
Cys Glu Phe Gly 420 425 430 Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala
Trp Ser His Pro Gln Phe 435 440 445 Glu Lys 450 <210> SEQ ID
NO 54 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Affinity tag linker element <400>
SEQUENCE: 54 Gly Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala 1 5 10
<210> SEQ ID NO 55 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Affinity tag linker element
<400> SEQUENCE: 55 Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala 1
5 10 <210> SEQ ID NO 56 <211> LENGTH: 12 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Flexible linker element
<400> SEQUENCE: 56 Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly
Ser Gly 1 5 10 <210> SEQ ID NO 57 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Affinity tag
linker element <400> SEQUENCE: 57 Gly Pro Ser Ser Ser Ser Ser
Ser Ala 1 5 <210> SEQ ID NO 58 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Flexible linker
element <400> SEQUENCE: 58 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Thr Gly 1 5 10 15 <210> SEQ ID NO 59
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: Q8IWL2 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(248)
<400> SEQUENCE: 59 Met Trp Leu Cys Pro Leu Ala Leu Asn Leu
Ile Leu Met Ala Ala Ser 1 5 10 15 Gly Ala Val Cys Glu Val Lys Asp
Val Cys Val Gly Ser Pro Gly Ile 20 25 30 Pro Gly Thr Pro Gly Ser
His Gly Leu Pro Gly Arg Asp Gly Arg Asp 35 40 45 Gly Leu Lys Gly
Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 50 55 60 Glu Met
Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro Gly Ala Pro Gly 65 70 75 80
Ile Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro 85
90 95 Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu
His 100 105 110 Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu
Ser Leu Gln 115 120 125 Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe
Ser Ser Asn Gly Gln 130 135 140 Ser Ile Thr Phe Asp Ala Ile Gln Glu
Ala Cys Ala Arg Ala Gly Gly 145 150 155 160 Arg Ile Ala Val Pro Arg
Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 165 170 175 Phe Val Lys Lys
Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 180 185 190 Pro Ser
Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 195 200 205
Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 210
215 220 Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu
Tyr 225 230 235 240 Ser Arg Leu Thr Ile Cys Glu Phe 245 <210>
SEQ ID NO 60 <211> LENGTH: 248 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: Q8IWL1
<309> DATABASE ENTRY DATE: 2008-12-16 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(248) <400> SEQUENCE: 60 Met Trp
Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 1 5 10 15
Gly Ala Ala Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 20
25 30 Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg
Asp 35 40 45 Gly Val Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly
Pro Pro Gly 50 55 60 Glu Thr Pro Cys Pro Pro Gly Asn Asn Gly Leu
Pro Gly Ala Pro Gly 65 70 75 80 Val Pro Gly Glu Arg Gly Glu Lys Gly
Glu Ala Gly Glu Arg Gly Pro 85 90 95 Pro Gly Leu Pro Ala His Leu
Asp Glu Glu Leu Gln Ala Thr Leu His 100 105 110 Asp Phe Arg His Gln
Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 115 120 125 Gly Ser Ile
Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 130 135 140 Ser
Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 145 150
155 160 Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala
Ser 165 170 175 Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu
Thr Glu Gly 180 185 190 Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly
Thr Pro Val Asn Tyr 195 200 205 Thr Asn Trp Tyr Arg Gly Glu Pro Ala
Gly Arg Gly Lys Glu Gln Cys 210 215 220 Val Glu Met Tyr Thr Asp Gly
Gln Trp Asn Asp Arg Asn Cys Leu Tyr 225 230 235 240 Ser Arg Leu Thr
Ile Cys Glu Phe 245 <210> SEQ ID NO 61 <211> LENGTH:
248 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: P11226 <309> DATABASE ENTRY DATE: 2008-12-16
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(248) <400>
SEQUENCE: 61 Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser
Met Val Ala 1 5 10 15 Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp
Ala Gln Lys Thr Cys 20 25 30 Pro Ala Val Ile Ala Cys Ser Ser Pro
Gly Ile Asn Gly Phe Pro Gly 35 40 45 Lys Asp Gly Arg Asp Gly Thr
Lys Gly Glu Lys Gly Glu Pro Gly Gln 50 55 60 Gly Leu Arg Gly Leu
Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 65 70 75 80 Asn Pro Gly
Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 85 90 95 Pro
Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 100 105
110 Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe
115 120 125 Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn
Gly Glu 130 135 140 Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val
Lys Phe Gln Ala 145 150 155 160 Ser Val Ala Thr Pro Arg Asn Ala Ala
Glu Asn Gly Ala Ile Gln Asn 165 170 175 Leu Ile Lys Glu Glu Ala Phe
Leu Gly Ile Thr Asp Glu Lys Thr Glu 180 185 190 Gly Gln Phe Val Asp
Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 195 200 205 Asn Glu Gly
Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 210 215 220 Leu
Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 225 230
235 240 Leu Ala Val Cys Glu Phe Pro Ile 245 <210> SEQ ID NO
62 <211> LENGTH: 277 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: Q9Y6Z7 <309> DATABASE
ENTRY DATE: 2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(277) <400> SEQUENCE: 62 Met Asn Gly Phe Ala Ser Leu Leu
Arg Arg Asn Gln Phe Ile Leu Leu 1 5 10 15 Val Leu Phe Leu Leu Gln
Ile Gln Ser Leu Gly Leu Asp Ile Asp Ser 20 25 30 Arg Pro Thr Ala
Glu Val Cys Ala Thr His Thr Ile Ser Pro Gly Pro 35 40 45 Lys Gly
Asp Asp Gly Glu Lys Gly Asp Pro Gly Glu Glu Gly Lys His 50 55 60
Gly Lys Val Gly Arg Met Gly Pro Lys Gly Ile Lys Gly Glu Leu Gly 65
70 75 80 Asp Met Gly Asp Gln Gly Asn Ile Gly Lys Thr Gly Pro Ile
Gly Lys 85 90 95 Lys Gly Asp Lys Gly Glu Lys Gly Leu Leu Gly Ile
Pro Gly Glu Lys 100 105 110 Gly Lys Ala Gly Thr Val Cys Asp Cys Gly
Arg Tyr Arg Lys Phe Val 115 120 125 Gly Gln Leu Asp Ile Ser Ile Ala
Arg Leu Lys Thr Ser Met Lys Phe 130 135 140 Val Lys Asn Val Ile Ala
Gly Ile Arg Glu Thr Glu Glu Lys Phe Tyr 145 150 155 160 Tyr Ile Val
Gln Glu Glu Lys Asn Tyr Arg Glu Ser Leu Thr His Cys 165 170 175 Arg
Ile Arg Gly Gly Met Leu Ala Met Pro Lys Asp Glu Ala Ala Asn 180 185
190 Thr Leu Ile Ala Asp Tyr Val Ala Lys Ser Gly Phe Phe Arg Val Phe
195 200 205 Ile Gly Val Asn Asp Leu Glu Arg Glu Gly Gln Tyr Met Phe
Thr Asp 210 215 220 Asn Thr Pro Leu Gln Asn Tyr Ser Asn Trp Asn Glu
Gly Glu Pro Ser 225 230 235 240 Asp Pro Tyr Gly His Glu Asp Cys Val
Glu Met Leu Ser Ser Gly Arg 245 250 255 Trp Asn Asp Thr Glu Cys His
Leu Thr Met Tyr Phe Val Cys Glu Phe 260 265 270 Ile Lys Lys Lys Lys
275 <210> SEQ ID NO 63 <211> LENGTH: 742 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
Q5KU26 <309> DATABASE ENTRY DATE: 2008-12-16 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(742) <400> SEQUENCE: 63
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 1 5
10 15 Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys
Asn 20 25 30 Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile
Leu Cys Ala 35 40 45 Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr
Lys Val Val Glu Lys 50 55 60 Met Asp Asn Val Thr Gly Gly Met Glu
Thr Ser Arg Gln Thr Tyr Asp 65 70 75 80 Asp Lys Leu Thr Ala Val Glu
Ser Asp Leu Lys Lys Leu Gly Asp Gln 85 90 95 Thr Gly Lys Lys Ala
Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 100 105 110 Ser Asp Ile
Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 115 120 125 Thr
Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 130 135
140 Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn
145 150 155 160 Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala
Tyr Asn Gly 165 170 175 Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val
Leu Gln Gly Asn Leu 180 185 190 Gln Asn Gln Met Tyr Ser His Asn Val
Val Ile Met Asn Leu Asn Asn 195 200 205 Leu Asn Leu Thr Gln Val Gln
Gln Arg Asn Leu Ile Thr Asn Leu Gln 210 215 220 Arg Ser Val Asp Asp
Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 225 230 235 240 Phe Gln
Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 245 250 255
Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 260
265 270 Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn
Ser 275 280 285 Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr
Thr Ile Ser 290 295 300 Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln
Asp Leu His Lys Asp 305 310 315 320 Ala Glu Asn Arg Thr Ala Ile Lys
Phe Asn Gln Leu Glu Glu Arg Phe 325 330 335 Gln Leu Phe Glu Thr Asp
Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 340 345 350 Thr Ala His His
Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 355 360 365 Thr Thr
Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 370 375 380
Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 385
390 395 400 Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val
Ala Asn 405 410 415 Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp
Ser Lys His Gly 420 425 430 Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln
Gly Pro Pro Gly Pro Arg 435 440 445 Gly Pro Arg Gly Asp Arg Gly Ser
Gln Gly Pro Pro Gly Pro Thr Gly 450 455 460 Asn Lys Gly Gln Lys Gly
Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 465 470 475 480 Ala Gly Glu
Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 485 490 495 Gly
Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 500 505
510 Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro
515 520 525 Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly
Pro Pro 530 535 540 Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro
Gly Val Pro Gly 545 550 555 560 Pro Arg Gly Leu Pro Gly Leu Pro Gly
Val Pro Gly Met Pro Gly Pro 565 570 575 Lys Gly Pro Pro Gly Pro Pro
Gly Pro Ser Gly Ala Val Val Pro Leu 580 585 590 Ala Leu Gln Asn Glu
Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 595 600 605 Pro His Trp
Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 610 615 620 Lys
Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 625 630
635 640 His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys
Lys 645 650 655 Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr
Asp Ser Glu 660 665 670 Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr
Ser Pro Asp Tyr Lys 675 680 685 Asn Trp Lys Ala Gly Gln Pro Asp Asn
Trp Gly His Gly His Gly Pro 690 695 700 Gly Glu Asp Cys Ala Gly Leu
Ile Tyr Ala Gly Gln Trp Asn Asp Phe 705 710 715 720 Gln Cys Glu Asp
Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 725 730 735 Val Leu
Ser Ser Ala Leu 740
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 63 <210>
SEQ ID NO 1 <211> LENGTH: 205 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (59)..(205) <223>
OTHER INFORMATION: Preferred receptor binding domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(60)..(205) <223> OTHER INFORMATION: Preferred receptor
binding domain <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: NP_000586 <309> DATABASE ENTRY
DATE: 2009-01-04 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(205) <400> SEQUENCE: 1 Met Thr Pro Pro Glu Arg Leu Phe
Leu Pro Arg Val Cys Gly Thr Thr 1 5 10 15 Leu His Leu Leu Leu Leu
Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 20 25 30 Gln Gly Leu Pro
Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 35 40 45 Arg Gln
His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 50 55 60
Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 65
70 75 80 Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu
Ser Asn 85 90 95 Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe
Val Tyr Ser Gln 100 105 110 Val Val Phe Ser Gly Lys Ala Tyr Ser Pro
Lys Ala Thr Ser Ser Pro 115 120 125 Leu Tyr Leu Ala His Glu Val Gln
Leu Phe Ser Ser Gln Tyr Pro Phe 130 135 140 His Val Pro Leu Leu Ser
Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 145 150 155 160 Glu Pro Trp
Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 165 170 175 Gln
Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 180 185
190 Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 195 200 205
<210> SEQ ID NO 2 <211> LENGTH: 233 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (86)..(233)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_000585 <309> DATABASE ENTRY DATE: 2008-12-28
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(233) <400>
SEQUENCE: 2 Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu
Glu Ala 1 5 10 15 Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg
Arg Cys Leu Phe 20 25 30 Leu Ser Leu Phe Ser Phe Leu Ile Val Ala
Gly Ala Thr Thr Leu Phe 35 40 45 Cys Leu Leu His Phe Gly Val Ile
Gly Pro Gln Arg Glu Glu Phe Pro 50 55 60 Arg Asp Leu Ser Leu Ile
Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 65 70 75 80 Ser Arg Thr Pro
Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 85 90 95 Gln Ala
Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 100 105 110
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 115
120 125 Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln
Gly 130 135 140 Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser
Arg Ile Ala 145 150 155 160 Val Ser Tyr Gln Thr Lys Val Asn Leu Leu
Ser Ala Ile Lys Ser Pro 165 170 175 Cys Gln Arg Glu Thr Pro Glu Gly
Ala Glu Ala Lys Pro Trp Tyr Glu 180 185 190 Pro Ile Tyr Leu Gly Gly
Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 195 200 205 Ser Ala Glu Ile
Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 210 215 220 Gln Val
Tyr Phe Gly Ile Ile Ala Leu 225 230 <210> SEQ ID NO 3
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (82)..(244) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (86)..(244) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_002332 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(244) <400> SEQUENCE: 3
Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 1 5
10 15 Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr
Leu 20 25 30 Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala
Leu Val Pro 35 40 45 Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala
Asp Pro Gly Ala Gln 50 55 60 Ala Gln Gln Gly Leu Gly Phe Gln Lys
Leu Pro Glu Glu Glu Pro Glu 65 70 75 80 Thr Asp Leu Ser Pro Gly Leu
Pro Ala Ala His Leu Ile Gly Ala Pro 85 90 95 Leu Lys Gly Gln Gly
Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 100 105 110 Leu Thr Ser
Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 115 120 125 Gln
Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 130 135
140 Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg
145 150 155 160 Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly
Thr Pro Glu 165 170 175 Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro
Val Leu Asp Pro Ala 180 185 190 Arg Arg Gln Gly Tyr Gly Pro Leu Trp
Tyr Thr Ser Val Gly Phe Gly 195 200 205 Gly Leu Val Gln Leu Arg Arg
Gly Glu Arg Val Tyr Val Asn Ile Ser 210 215 220 His Pro Asp Met Val
Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 225 230 235 240 Val Met
Val Gly <210> SEQ ID NO 4 <211> LENGTH: 183 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (52)..(183)
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (55)..(183) <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_003317 <309>
DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(183) <400> SEQUENCE: 4 Met Glu Arg Val Gln
Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 1 5 10 15 Pro Arg Phe
Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 20 25 30 Gly
Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 35 40
45 Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val
50 55 60 Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr
Ser Gln 65 70 75 80 Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser
Val Ile Ile Asn 85 90 95 Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys
Gly Tyr Phe Ser Gln Glu 100 105 110 Val Asn Ile Ser Leu His Tyr Gln
Lys Asp Glu Glu Pro Leu Phe Gln 115 120 125 Leu Lys Lys Val Arg Ser
Val Asn Ser Leu Met Val Ala Ser Leu Thr 130 135 140 Tyr Lys Asp Lys
Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 145 150 155 160 Asp
Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 165 170
175 Pro Gly Glu Phe Cys Val Leu 180 <210> SEQ ID NO 5
<211> LENGTH: 261 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (112)..(261) <223>
OTHER INFORMATION: Preferred receptor binding domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(117)..(261) <223> OTHER INFORMATION: Preferred receptor
binding domain <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: NP_000065 <309> DATABASE ENTRY
DATE: 2008-12-28 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(261) <400> SEQUENCE: 5 Met Ile Glu Thr Tyr Asn Gln Thr
Ser Pro Arg Ser Ala Ala Thr Gly 1 5 10 15 Leu Pro Ile Ser Met Lys
Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 20 25 30 Ile Thr Gln Met
Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 35 40 45 Arg Leu
Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 50 55 60
Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 65
70 75 80 Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe
Val Lys 85 90 95 Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu
Asn Ser Phe Glu 100 105 110 Met Gln Lys Gly Asp Gln Asn Pro Gln Ile
Ala Ala His Val Ile Ser 115 120 125 Glu Ala Ser Ser Lys Thr Thr Ser
Val Leu Gln Trp Ala Glu Lys Gly 130 135 140 Tyr Tyr Thr Met Ser Asn
Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 145 150 155 160 Leu Thr Val
Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 165 170 175 Phe
Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 180 185
190 Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala
195 200 205 Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser
Ile His 210 215 220 Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser
Val Phe Val Asn 225 230 235 240 Val Thr Asp Pro Ser Gln Val Ser His
Gly Thr Gly Phe Thr Ser Phe 245 250 255 Gly Leu Leu Lys Leu 260
<210> SEQ ID NO 6 <211> LENGTH: 281 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (142)..(281)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (144)..(281) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_000630 <309>
DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(281) <400> SEQUENCE: 6 Met Gln Gln Pro Phe
Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 1 5 10 15 Ser Ser Ala
Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 20 25 30 Pro
Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 35 40
45 Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro
50 55 60 Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser
Thr Gly 65 70 75 80 Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val
Ala Leu Val Gly 85 90 95 Leu Gly Leu Gly Met Phe Gln Leu Phe His
Leu Gln Lys Glu Leu Ala 100 105 110 Glu Leu Arg Glu Ser Thr Ser Gln
Met His Thr Ala Ser Ser Leu Glu 115 120 125 Lys Gln Ile Gly His Pro
Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 130 135 140 Lys Val Ala His
Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 145 150 155 160 Glu
Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 165 170
175 Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr
180 185 190 Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro
Leu Ser 195 200 205 His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln
Asp Leu Val Met 210 215 220 Met Glu Gly Lys Met Met Ser Tyr Cys Thr
Thr Gly Gln Met Trp Ala 225 230 235 240 Arg Ser Ser Tyr Leu Gly Ala
Val Phe Asn Leu Thr Ser Ala Asp His 245 250 255 Leu Tyr Val Asn Val
Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 260 265 270 Gln Thr Phe
Phe Gly Leu Tyr Lys Leu 275 280 <210> SEQ ID NO 7 <211>
LENGTH: 193 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (51)..(193) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (56)..(193) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_001243 <309> DATABASE ENTRY DATE: 2008-12-14 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(193) <400> SEQUENCE: 7
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 1 5
10 15 Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val
Ile 20 25 30 Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln
Gln Gln Leu 35 40 45 Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu
Leu Gln Leu Asn His 50 55 60 Thr Gly Pro Gln Gln Asp Pro Arg Leu
Tyr Trp Gln Gly Gly Pro Ala 65 70 75 80 Leu Gly Arg Ser Phe Leu His
Gly Pro Glu Leu Asp Lys Gly Gln Leu 85 90 95 Arg Ile His Arg Asp
Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 100 105 110 Ala Ile Cys
Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 115 120 125 Ala
Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 130 135
140 Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro
145 150 155 160 Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly
Thr Leu Leu 165 170 175 Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly
Val Gln Trp Val Arg 180 185 190 Pro <210> SEQ ID NO 8
<211> LENGTH: 234 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (97)..(234) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (98)..(234) <223>
OTHER INFORMATION: Preferred receptor binding domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(102)..(234) <223> OTHER INFORMATION: Preferred receptor
binding domain <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: NP_001235 <309> DATABASE ENTRY
DATE: 2008-09-28 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(234) <400> SEQUENCE: 8 Met Asp Pro Gly Leu Gln Gln Ala
Leu Asn Gly Met Ala Pro Pro Gly 1 5 10 15 Asp Thr Ala Met His Val
Pro Ala Gly Ser Val Ala Ser His Leu Gly 20 25 30 Thr Thr Ser Arg
Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 35 40 45 Cys Leu
Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 50 55 60
Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 65
70 75 80 Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro
Phe Lys 85 90 95 Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu
Asn Lys Thr Lys 100 105 110 Leu Ser Trp Asn Lys Asp Gly Ile Leu His
Gly Val Arg Tyr Gln Asp 115 120 125 Gly Asn Leu Val Ile Gln Phe Pro
Gly Leu Tyr Phe Ile Ile Cys Gln 130 135 140 Leu Gln Phe Leu Val Gln
Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 145 150 155 160
Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 165
170 175 Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser
Gln 180 185 190 Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser
Val Asn Val 195 200 205 Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe
Pro Leu Glu Asn Val 210 215 220 Leu Ser Ile Phe Leu Tyr Ser Asn Ser
Asp 225 230 <210> SEQ ID NO 9 <211> LENGTH: 254
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (86)..(254) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_003802 <309>
DATABASE ENTRY DATE: 2008-10-24 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(254) <400> SEQUENCE: 9 Met Glu Tyr Ala Ser
Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 1 5 10 15 Pro Ala Pro
Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 20 25 30 Ala
Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 35 40
45 Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser
50 55 60 Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro
Asp Asp 65 70 75 80 Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe
Ala Gln Leu Val 85 90 95 Ala Gln Asn Val Leu Leu Ile Asp Gly Pro
Leu Ser Trp Tyr Ser Asp 100 105 110 Pro Gly Leu Ala Gly Val Ser Leu
Thr Gly Gly Leu Ser Tyr Lys Glu 115 120 125 Asp Thr Lys Glu Leu Val
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 130 135 140 Phe Gln Leu Glu
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 145 150 155 160 Val
Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 165 170
175 Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala
180 185 190 Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu
Ser Ala 195 200 205 Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala
Arg Ala Arg His 210 215 220 Ala Trp Gln Leu Thr Gln Gly Ala Thr Val
Leu Gly Leu Phe Arg Val 225 230 235 240 Thr Pro Glu Ile Pro Ala Gly
Leu Pro Ser Pro Arg Ser Glu 245 250 <210> SEQ ID NO 10
<211> LENGTH: 281 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (95)..(281) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (116)..(281) <223>
OTHER INFORMATION: Preferred receptor binding domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(117)..(281) <223> OTHER INFORMATION: Preferred receptor
binding domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (118)..(281) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (119)..(281) <223>
OTHER INFORMATION: Preferred receptor binding domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(120)..(281) <223> OTHER INFORMATION: Preferred receptor
binding domain <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: NP_003801 <309> DATABASE ENTRY
DATE: 2008-12-28 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(281) <400> SEQUENCE: 10 Met Ala Met Met Glu Val Gln Gly
Gly Pro Ser Leu Gly Gln Thr Cys 1 5 10 15 Val Leu Ile Val Ile Phe
Thr Val Leu Leu Gln Ser Leu Cys Val Ala 20 25 30 Val Thr Tyr Val
Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 35 40 45 Tyr Ser
Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 50 55 60
Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 65
70 75 80 Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg
Thr Ser 85 90 95 Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln
Asn Ile Ser Pro 100 105 110 Leu Val Arg Glu Arg Gly Pro Gln Arg Val
Ala Ala His Ile Thr Gly 115 120 125 Thr Arg Gly Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu 130 135 140 Lys Ala Leu Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 145 150 155 160 His Ser Phe
Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 165 170 175 His
Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 180 185
190 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln
195 200 205 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu
Met Lys 210 215 220 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu
Tyr Gly Leu Tyr 225 230 235 240 Ser Ile Tyr Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile 245 250 255 Phe Val Ser Val Thr Asn Glu
His Leu Ile Asp Met Asp His Glu Ala 260 265 270 Ser Phe Phe Gly Ala
Phe Leu Val Gly 275 280 <210> SEQ ID NO 11 <211>
LENGTH: 317 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (161)..(317) <223> OTHER INFORMATION:
Preferred receptor binding domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NP_003692
<309> DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(317) <400> SEQUENCE: 11 Met Arg
Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 1 5 10 15
Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 20
25 30 Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser
Met 35 40 45 Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val
Cys Ser Val 50 55 60 Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp
Pro Asn Arg Ile Ser 65 70 75 80 Glu Asp Gly Thr His Cys Ile Tyr Arg
Ile Leu Arg Leu His Glu Asn 85 90 95 Ala Asp Phe Gln Asp Thr Thr
Leu Glu Ser Gln Asp Thr Lys Leu Ile 100 105 110 Pro Asp Ser Cys Arg
Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 115 120 125 Lys Glu Leu
Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 130 135 140 Ala
Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 145 150
155 160 Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile
Pro 165 170 175 Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His
Asp Arg Gly 180 185 190 Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn
Gly Lys Leu Ile Val 195 200 205 Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr
Ala Asn Ile Cys Phe Arg His 210 215 220 His Glu Thr Ser Gly Asp Leu
Ala Thr Glu Tyr Leu Gln Leu Met Val 225 230 235 240 Tyr Val Thr Lys
Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 245 250 255 Lys Gly
Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 260 265 270
Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 275
280 285 Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln
Asp 290 295 300 Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp
305 310 315 <210> SEQ ID NO 12 <211> LENGTH: 249
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (103)..(249) <223> OTHER INFORMATION: Preferred
receptor binding domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (104)..(249) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (105)..(249)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_003800 <309> DATABASE ENTRY DATE: 2008-11-05
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(249) <400>
SEQUENCE: 12 Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg
Gly Glu Pro 1 5 10 15 Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly
Leu Gly Leu Ala Leu 20 25 30 Ala Cys Leu Gly Leu Leu Leu Ala Val
Val Ser Leu Gly Ser Arg Ala 35 40 45 Ser Leu Ser Ala Gln Glu Pro
Ala Gln Glu Glu Leu Val Ala Glu Glu 50 55 60 Asp Gln Asp Pro Ser
Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 65 70 75 80 Pro Ala Pro
Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 85 90 95 Lys
Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 100 105
110 Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly
115 120 125 Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser
Pro Leu 130 135 140 Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr
Arg Ala Gly Leu 145 150 155 160 Tyr Tyr Leu Tyr Cys Gln Val His Phe
Asp Glu Gly Lys Ala Val Tyr 165 170 175 Leu Lys Leu Asp Leu Leu Val
Asp Gly Val Leu Ala Leu Arg Cys Leu 180 185 190 Glu Glu Phe Ser Ala
Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 195 200 205 Leu Cys Gln
Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 210 215 220 Arg
Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 225 230
235 240 Thr Tyr Phe Gly Leu Phe Gln Val His 245 <210> SEQ ID
NO 13 <211> LENGTH: 247 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (112)..(247) <223> OTHER
INFORMATION: Preferred receptor binding domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (113)..(247)
<223> OTHER INFORMATION: Preferred receptor binding domain
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: NP_742085 <309> DATABASE ENTRY DATE: 2008-11-05
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(247) <400>
SEQUENCE: 13 Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly
Pro Pro Gly 1 5 10 15 Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu
Ser Val Ala Leu Trp 20 25 30 Leu Ser Trp Gly Ala Ala Leu Gly Ala
Val Ala Cys Ala Met Ala Leu 35 40 45 Leu Thr Gln Gln Thr Glu Leu
Gln Ser Leu Arg Arg Glu Val Ser Arg 50 55 60 Leu Gln Gly Thr Gly
Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 65 70 75 80 Gln Ser Leu
Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 85 90 95 Gly
Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 100 105
110 Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys
115 120 125 Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu
Arg Arg 130 135 140 Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg
Ile Gln Asp Ala 145 150 155 160 Gly Val Tyr Leu Leu Tyr Ser Gln Val
Leu Phe Gln Asp Val Thr Phe 165 170 175 Thr Met Gly Gln Val Val Ser
Arg Glu Gly Gln Gly Arg Gln Glu Thr 180 185 190 Leu Phe Arg Cys Ile
Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 195 200 205 Asn Ser Cys
Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 210 215 220 Leu
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 225 230
235 240 His Gly Thr Phe Leu Gly Leu 245 <210> SEQ ID NO 14
<211> LENGTH: 250 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (112)..(250) <223> OTHER INFORMATION:
Preferred receptor binding domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (113)..(250) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_003799 <309> DATABASE ENTRY DATE: 2008-11-05 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(250) <400> SEQUENCE: 14
Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 1 5
10 15 Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu
Trp 20 25 30 Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala
Met Ala Leu 35 40 45 Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg
Arg Glu Val Ser Arg 50 55 60 Leu Gln Gly Thr Gly Gly Pro Ser Gln
Asn Gly Glu Gly Tyr Pro Trp 65 70 75 80 Gln Ser Leu Pro Glu Gln Ser
Ser Asp Ala Leu Glu Ala Trp Glu Asn 85 90 95 Gly Glu Arg Ser Arg
Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 100 105 110 Lys Gln His
Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 115 120 125 Asp
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 130 135
140 Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala
145 150 155 160 Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp
Val Thr Phe 165 170 175 Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln
Gly Arg Gln Glu Thr 180 185 190 Leu Phe Arg Cys Ile Arg Ser Met Pro
Ser His Pro Asp Arg Ala Tyr 195 200 205 Asn Ser Cys Tyr Ser Ala Gly
Val Phe His Leu His Gln Gly Asp Ile 210 215 220 Leu Ser Val Ile Ile
Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 225 230 235 240 His Gly
Thr Phe Leu Gly Phe Val Lys Leu 245 250 <210> SEQ ID NO 15
<211> LENGTH: 285 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (140)..(285) <223> OTHER INFORMATION:
Preferred receptor binding domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NP_006564
<309> DATABASE ENTRY DATE: 2008-02-11 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(285) <400> SEQUENCE: 15 Met Asp
Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 1 5 10 15
Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 20
25 30 Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu
Leu 35 40 45 Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu
Thr Val Val 50 55 60 Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp
Leu Ala Ser Leu Arg 65 70 75 80 Ala Glu Leu Gln Gly His His Ala Glu
Lys Leu Pro Ala Gly Ala Gly 85 90 95 Ala Pro Lys Ala Gly Leu Glu
Glu Ala Pro Ala Val Thr Ala Gly Leu 100 105 110 Lys Ile Phe Glu Pro
Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 115 120 125 Ser Arg Asn
Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 130 135 140 Asp
Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 145 150
155 160 Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly
Ser 165 170 175
Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 180
185 190 Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala
Met 195 200 205 Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly
Asp Glu Leu 210 215 220 Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn
Met Pro Glu Thr Leu 225 230 235 240 Pro Asn Asn Ser Cys Tyr Ser Ala
Gly Ile Ala Lys Leu Glu Glu Gly 245 250 255 Asp Glu Leu Gln Leu Ala
Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 260 265 270 Asp Gly Asp Val
Thr Phe Phe Gly Ala Leu Lys Leu Leu 275 280 285 <210> SEQ ID
NO 16 <211> LENGTH: 240 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (91)..(240) <223> OTHER
INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_003798 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(240) <400> SEQUENCE: 16
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 1 5
10 15 Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln
Ser 20 25 30 Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu
Leu Met Gly 35 40 45 Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu
Gln Leu His Trp Arg 50 55 60 Leu Gly Glu Met Val Thr Arg Leu Pro
Asp Gly Pro Ala Gly Ser Trp 65 70 75 80 Glu Gln Leu Ile Gln Glu Arg
Arg Ser His Glu Val Asn Pro Ala Ala 85 90 95 His Leu Thr Gly Ala
Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 100 105 110 Leu Trp Glu
Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 115 120 125 His
Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 130 135
140 Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser
145 150 155 160 Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr
Pro Glu Glu 165 170 175 Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys
Gly Arg Ala Thr Ser 180 185 190 Ser Ser Arg Val Trp Trp Asp Ser Ser
Phe Leu Gly Gly Val Val His 195 200 205 Leu Glu Ala Gly Glu Lys Val
Val Val Arg Val Leu Asp Glu Arg Leu 210 215 220 Val Arg Leu Arg Asp
Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 225 230 235 240
<210> SEQ ID NO 17 <211> LENGTH: 251 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (91)..(251)
<223> OTHER INFORMATION: Preferred receptor binding domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (93)..(251) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_005109 <309>
DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(251) <400> SEQUENCE: 17 Met Ala Glu Asp Leu
Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 1 5 10 15 Met Leu Pro
Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 20 25 30 Ala
Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 35 40
45 Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu
50 55 60 Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala
Pro Ser 65 70 75 80 His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly
Asp Lys Pro Arg 85 90 95 Ala His Leu Thr Val Val Arg Gln Thr Pro
Thr Gln His Phe Lys Asn 100 105 110 Gln Phe Pro Ala Leu His Trp Glu
His Glu Leu Gly Leu Ala Phe Thr 115 120 125 Lys Asn Arg Met Asn Tyr
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 130 135 140 Gly Asp Tyr Phe
Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 145 150 155 160 Glu
Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 165 170
175 Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr
180 185 190 Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser
Asn Trp 195 200 205 Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu
Gln Glu Gly Asp 210 215 220 Lys Leu Met Val Asn Val Ser Asp Ile Ser
Leu Val Asp Tyr Thr Lys 225 230 235 240 Glu Asp Lys Thr Phe Phe Gly
Ala Phe Leu Leu 245 250 <210> SEQ ID NO 18 <211>
LENGTH: 199 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (52)..(177) <223> OTHER INFORMATION:
Preferred receptor binding domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: NP_005083
<309> DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(199) <400> SEQUENCE: 18 Met Thr
Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 1 5 10 15
Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 20
25 30 Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys
Leu 35 40 45 Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys
Ser Phe Ser 50 55 60 Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr
Ala Lys Glu Pro Cys 65 70 75 80 Met Ala Lys Phe Gly Pro Leu Pro Ser
Lys Trp Gln Met Ala Ser Ser 85 90 95 Glu Pro Pro Cys Val Asn Lys
Val Ser Asp Trp Lys Leu Glu Ile Leu 100 105 110 Gln Asn Gly Leu Tyr
Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 115 120 125 Tyr Asn Asp
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 130 135 140 Met
Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 145 150
155 160 Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn
Ser 165 170 175 Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile
Ile Leu Leu 180 185 190 Ala Asn Pro Gln Phe Ile Ser 195 <210>
SEQ ID NO 19 <211> LENGTH: 391 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (245)..(391) <223>
OTHER INFORMATION: Preferred receptor binding domain <300>
PUBLICATION INFORMATION: <308> DATABASE ACCESSION NUMBER:
NP_001390 <309> DATABASE ENTRY DATE: 2008-12-21 <313>
RELEVANT RESIDUES IN SEQ ID NO: (1)..(391) <400> SEQUENCE: 19
Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 1 5
10 15 Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro
Ala 20 25 30 Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly
Phe Phe Gly 35 40 45 Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys
Cys Tyr Leu Glu Leu 50 55 60 Arg Ser Glu Leu Arg Arg Glu Arg Gly
Ala Glu Ser Arg Leu Gly Gly 65 70 75 80 Ser Gly Thr Pro Gly Thr Ser
Gly Thr Leu Ser Ser Leu Gly Gly Leu 85 90 95 Asp Pro Asp Ser Pro
Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 100 105 110 Gln Gln Pro
Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 115 120 125 Asp
Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 130 135
140 Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser
145 150 155 160
Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 165
170 175 Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro
Gly 180 185 190 Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile
Pro Gly Ile 195 200 205 Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro
Pro Gly Pro Pro Gly 210 215 220 Pro Gln Gly Pro Pro Gly Leu Gln Gly
Pro Ser Gly Ala Ala Asp Lys 225 230 235 240 Ala Gly Thr Arg Glu Asn
Gln Pro Ala Val Val His Leu Gln Gly Gln 245 250 255 Gly Ser Ala Ile
Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 260 265 270 Asp Trp
Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 275 280 285
Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 290
295 300 Ser Gln Val Glu Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser
Tyr 305 310 315 320 Glu Val Val Val Asp Glu Lys Pro Phe Leu Gln Cys
Thr Arg Ser Ile 325 330 335 Glu Thr Gly Lys Thr Asn Tyr Asn Thr Cys
Tyr Thr Ala Gly Val Cys 340 345 350 Leu Leu Lys Ala Arg Gln Lys Ile
Ala Val Lys Met Val His Ala Asp 355 360 365 Ile Ser Ile Asn Met Ser
Lys His Thr Thr Phe Phe Gly Ala Ile Arg 370 375 380 Leu Gly Glu Ala
Pro Ala Ser 385 390 <210> SEQ ID NO 20 <211> LENGTH:
389 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (245)..(389) <223> OTHER INFORMATION: Preferred
receptor binding domain <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: NP_001005609 <309>
DATABASE ENTRY DATE: 2008-12-21 <313> RELEVANT RESIDUES IN
SEQ ID NO: (1)..(389) <400> SEQUENCE: 20 Met Gly Tyr Pro Glu
Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 1 5 10 15 Pro Arg Glu
Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 20 25 30 Arg
Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 35 40
45 Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu
50 55 60 Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu
Gly Gly 65 70 75 80 Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser
Leu Gly Gly Leu 85 90 95 Asp Pro Asp Ser Pro Ile Thr Ser His Leu
Gly Gln Pro Ser Pro Lys 100 105 110 Gln Gln Pro Leu Glu Pro Gly Glu
Ala Ala Leu His Ser Asp Ser Gln 115 120 125 Asp Gly His Gln Met Ala
Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 130 135 140 Pro Tyr Ser Glu
Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 145 150 155 160 Lys
Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 165 170
175 Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly
180 185 190 Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro
Gly Ile 195 200 205 Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro
Gly Pro Pro Gly 210 215 220 Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro
Ser Gly Ala Ala Asp Lys 225 230 235 240 Ala Gly Thr Arg Glu Asn Gln
Pro Ala Val Val His Leu Gln Gly Gln 245 250 255 Gly Ser Ala Ile Gln
Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 260 265 270 Asp Trp Ser
Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 275 280 285 Arg
Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 290 295
300 Ser Gln Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val
305 310 315 320 Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser
Ile Glu Thr 325 330 335 Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala
Gly Val Cys Leu Leu 340 345 350 Lys Ala Arg Gln Lys Ile Ala Val Lys
Met Val His Ala Asp Ile Ser 355 360 365 Ile Asn Met Ser Lys His Thr
Thr Phe Phe Gly Ala Ile Arg Leu Gly 370 375 380 Glu Ala Pro Ala Ser
385 <210> SEQ ID NO 21 <211> LENGTH: 375 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (217)..(375)
<223> OTHER INFORMATION: Preferred collectin trimerization
domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (217)..(257) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (218)..(375) <223> OTHER
INFORMATION: Preferred collectin trimerization domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(218)..(257) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (219)..(375) <223> OTHER INFORMATION: Preferred
collectin trimerization domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (219)..(257) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (220)..(375)
<223> OTHER INFORMATION: Preferred collectin trimerization
domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (220)..(257) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (221)..(375) <223> OTHER
INFORMATION: Preferred collectin trimerization domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(221)..(257) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (222)..(375) <223> OTHER INFORMATION: Preferred
collectin trimerization domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (222)..(257) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (223)..(375)
<223> OTHER INFORMATION: Preferred collectin trimerization
domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (223)..(257) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (224)..(375) <223> OTHER
INFORMATION: Preferred collectin trimerization domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(224)..(257) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (225)..(375) <223> OTHER INFORMATION: Preferred
collectin trimerization domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (225)..(257) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (258)..(375)
<223> OTHER INFORMATION: Preferred carbohydrate recognition
domain <300> PUBLICATION INFORMATION: <308> DATABASE
ACCESSION NUMBER: P35247 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(375)
<400> SEQUENCE: 21 Met Leu Leu Phe Leu Leu Ser Ala Leu Val
Leu Leu Thr Gln Pro Leu 1 5 10 15 Gly Tyr Leu Glu Ala Glu Met Lys
Thr Tyr Ser His Arg Thr Met Pro 20 25 30 Ser Ala Cys Thr Leu Val
Met Cys Ser Ser Val Glu Ser Gly Leu Pro 35 40 45 Gly Arg Asp Gly
Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly 50 55 60 Asp Pro
Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln 65 70 75 80
Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro 85
90 95 Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro
Gly 100 105 110 Val Pro Gly Pro Ala Gly Arg Glu Gly Pro Leu Gly Lys
Gln Gly Asn 115 120 125 Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly
Glu Ala Gly Pro Lys 130 135 140
Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 145
150 155 160 Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg
Gly Val 165 170 175 Pro Gly Asn Ala Gly Ala Ala Gly Ser Ala Gly Ala
Met Gly Pro Gln 180 185 190 Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly
Leu Lys Gly Asp Lys Gly 195 200 205 Ile Pro Gly Asp Lys Gly Ala Lys
Gly Glu Ser Gly Leu Pro Asp Val 210 215 220 Ala Ser Leu Arg Gln Gln
Val Glu Ala Leu Gln Gly Gln Val Gln His 225 230 235 240 Leu Gln Ala
Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 245 250 255 Gly
Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 260 265
270 Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu
275 280 285 Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln
Leu Val 290 295 300 Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr
Asp Ser Lys Thr 305 310 315 320 Glu Gly Lys Phe Thr Tyr Pro Thr Gly
Glu Ser Leu Val Tyr Ser Asn 325 330 335 Trp Ala Pro Gly Glu Pro Asn
Asp Asp Gly Gly Ser Glu Asp Cys Val 340 345 350 Glu Ile Phe Thr Asn
Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 355 360 365 Arg Leu Val
Val Cys Glu Phe 370 375 <210> SEQ ID NO 22 <211>
LENGTH: 271 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (110)..(147) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (110)..(148) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (110)..(149) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (110)..(150)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(110)..(151) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (116)..(147) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (116)..(148) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (116)..(149) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (116)..(150) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (116)..(151)
<223> OTHER INFORMATION: Preferred neck domain <220>
FEATURE: <221> NAME/KEY: DOMAIN <222> LOCATION:
(121)..(147) <223> OTHER INFORMATION: Preferred neck domain
<220> FEATURE: <221> NAME/KEY: DOMAIN <222>
LOCATION: (121)..(148) <223> OTHER INFORMATION: Preferred
neck domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (121)..(149) <223> OTHER INFORMATION:
Preferred neck domain <220> FEATURE: <221> NAME/KEY:
DOMAIN <222> LOCATION: (121)..(150) <223> OTHER
INFORMATION: Preferred neck domain <220> FEATURE: <221>
NAME/KEY: DOMAIN <222> LOCATION: (121)..(151) <223>
OTHER INFORMATION: Preferred neck domain <220> FEATURE:
<221> NAME/KEY: DOMAIN <222> LOCATION: (149)..(271)
<223> OTHER INFORMATION: Preferred carbohydrate recognition
domain <220> FEATURE: <221> NAME/KEY: DOMAIN
<222> LOCATION: (152)..(271) <223> OTHER INFORMATION:
Preferred carbohydrate recognition domain <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: Q9BWP8
<309> DATABASE ENTRY DATE: 2008-12-16 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(271) <400> SEQUENCE: 22 Met Arg
Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 1 5 10 15
Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 20
25 30 Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly
Glu 35 40 45 Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val
Gly Pro Thr 50 55 60 Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln
Lys Gly Ser Val Gly 65 70 75 80 Arg His Gly Lys Ile Gly Pro Ile Gly
Ser Lys Gly Glu Lys Gly Asp 85 90 95 Ser Gly Asp Ile Gly Pro Pro
Gly Pro Asn Gly Glu Pro Gly Leu Pro 100 105 110 Cys Glu Cys Ser Gln
Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 115 120 125 Val Ser Gln
Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 130 135 140 Gly
Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 145 150
155 160 Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly
Thr 165 170 175 Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met
Ala Ala Tyr 180 185 190 Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile
Gly Ile Asn Asp Leu 195 200 205 Glu Lys Glu Gly Ala Phe Val Tyr Ser
Asp His Ser Pro Met Arg Thr 210 215 220 Phe Asn Lys Trp Arg Ser Gly
Glu Pro Asn Asn Ala Tyr Asp Glu Glu 225 230 235 240 Asp Cys Val Glu
Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 245 250 255 His Thr
Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 260 265 270
<210> SEQ ID NO 23 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Signal peptide <400> SEQUENCE:
23 Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly
1 5 10 15 Val Gln Cys <210> SEQ ID NO 24 <211> LENGTH:
20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Signal peptide
<400> SEQUENCE: 24 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly 20 <210>
SEQ ID NO 25 <211> LENGTH: 20 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Signal peptide <400> SEQUENCE:
25 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
1 5 10 15 Ala Gly Asn Gly 20 <210> SEQ ID NO 26 <211>
LENGTH: 339 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(182)
<223> OTHER INFORMATION: TRAIL receptor binding domain
(residues 120-281 of SEQ ID NO:10) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (183)..(339)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 219-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (183)..(221)
<223> OTHER INFORMATION: SP-D neck region (residues 219-257
of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (222)..(339) <223> OTHER INFORMATION:
SP-D CRD (residues 258-375 of SEQ ID NO:21) <400> SEQUENCE:
26 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr
Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn
Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser
Arg Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn
Gly Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr
Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn
Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr
Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125
Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130
135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val
Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu
Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Gly Leu Pro
Asp Val Ala Ser Leu Arg 180 185 190 Gln Gln Val Glu Ala Leu Gln Gly
Gln Val Gln His Leu Gln Ala Ala 195 200 205 Phe Ser Gln Tyr Lys Lys
Val Glu Leu Phe Pro Asn Gly Gln Ser Val 210 215 220 Gly Glu Lys Ile
Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 225 230 235 240 Ala
Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 245 250
255 Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn
260 265 270 Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly
Lys Phe 275 280 285 Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn
Trp Ala Pro Gly 290 295 300 Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp
Cys Val Glu Ile Phe Thr 305 310 315 320 Asn Gly Lys Trp Asn Asp Arg
Ala Cys Gly Glu Lys Arg Leu Val Val 325 330 335 Cys Glu Phe
<210> SEQ ID NO 27 <211> LENGTH: 343 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(186) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 116-281 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(343) <223> OTHER INFORMATION: SP-D collectin
trimerization domain (residues 219-375 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(225) <223> OTHER INFORMATION: SP-D neck region
(residues 219-257 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (226)..(343)
<223> OTHER INFORMATION: SP-D CRD (residues 258-375 of SEQ ID
NO:21) <400> SEQUENCE: 27 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu Arg Gly
Pro Gln Arg Val Ala Ala His Ile Thr 20 25 30 Gly Thr Arg Gly Arg
Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 35 40 45 Glu Lys Ala
Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 50 55 60 Gly
His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 65 70
75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe
Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys
Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp
Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala Arg Asn Ser Cys Trp Ser
Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr Ser Ile Tyr Gln Gly Gly
Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150 155 160 Ile Phe Val Ser
Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 165 170 175 Ala Ser
Phe Phe Gly Ala Phe Leu Val Gly Ser Gly Leu Pro Asp Val 180 185 190
Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 195
200 205 Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro
Asn 210 215 220 Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly
Phe Val Lys 225 230 235 240 Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr
Gln Ala Gly Gly Gln Leu 245 250 255 Ala Ser Pro Arg Ser Ala Ala Glu
Asn Ala Ala Leu Gln Gln Leu Val 260 265 270 Val Ala Lys Asn Glu Ala
Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 275 280 285 Glu Gly Lys Phe
Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 290 295 300 Trp Ala
Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 305 310 315
320 Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys
325 330 335 Arg Leu Val Val Cys Glu Phe 340 <210> SEQ ID NO
28 <211> LENGTH: 225 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(186) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 116-281 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(225) <223> OTHER INFORMATION: SP-D neck region
(residues 219-257 of SEQ ID NO:21) <400> SEQUENCE: 28 Met Glu
Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15
Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 20
25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys
Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser
Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His Leu Arg
Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile
Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu
Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys
Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr
Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150
155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His
Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Gly Leu
Pro Asp Val 180 185 190 Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
Gly Gln Val Gln His 195 200 205 Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val Glu Leu Phe Pro Asn 210 215 220 Gly 225 <210> SEQ ID
NO 29 <211> LENGTH: 338
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide 3
(SEQ ID NO:25) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(182) <223> OTHER
INFORMATION: TRAIL receptor binding domain (residues 120-281 of SEQ
ID NO:10) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (183)..(338) <223> OTHER INFORMATION:
Collectin-11 collectin trimerization domain (residues 116-271 of
SEQ ID NO:22) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (183)..(218) <223> OTHER
INFORMATION: Collectin-11 neck region (residues 116-151 of SEQ ID
NO:22) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (219)..(338) <223> OTHER INFORMATION:
Collectin-11 CRD (residues 152-271 of SEQ ID NO:22) <400>
SEQUENCE: 29 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu
Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile
Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn
Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp
Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His
Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr
Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile
Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105
110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg
115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser
Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg
Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met
Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser
Gln Leu Arg Lys Ala Ile Gly Glu Met 180 185 190 Asp Asn Gln Val Ser
Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn 195 200 205 Ala Val Ala
Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val 210 215 220 Lys
Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg 225 230
235 240 Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu
Met 245 250 255 Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val Phe
Ile Gly Ile 260 265 270 Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr
Ser Asp His Ser Pro 275 280 285 Met Arg Thr Phe Asn Lys Trp Arg Ser
Gly Glu Pro Asn Asn Ala Tyr 290 295 300 Asp Glu Glu Asp Cys Val Glu
Met Val Ala Ser Gly Gly Trp Asn Asp 305 310 315 320 Val Ala Cys His
Thr Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu 325 330 335 Asn Met
<210> SEQ ID NO 30 <211> LENGTH: 342 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(186) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 116-281 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(342) <223> OTHER INFORMATION: Collectin-11 collectin
trimerization domain (residues 116-271 of SEQ ID NO:22) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(222) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 116-151 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(223)..(342) <223> OTHER INFORMATION: Collectin-11 CRD
(residues 152-271 of SEQ ID NO:22) <400> SEQUENCE: 30 Met Glu
Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15
Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 20
25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys
Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser
Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His Leu Arg
Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr Tyr Ile
Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile Lys Glu
Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110 Gln Tyr Ile Tyr Lys
Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115 120 125 Lys Ser Ala
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 130 135 140 Tyr
Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 145 150
155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His
Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Gln Leu
Arg Lys Ala 180 185 190 Ile Gly Glu Met Asp Asn Gln Val Ser Gln Leu
Thr Ser Glu Leu Lys 195 200 205 Phe Ile Lys Asn Ala Val Ala Gly Val
Arg Glu Thr Glu Ser Lys Ile 210 215 220 Tyr Leu Leu Val Lys Glu Glu
Lys Arg Tyr Ala Asp Ala Gln Leu Ser 225 230 235 240 Cys Gln Gly Arg
Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala Ala 245 250 255 Asn Gly
Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val 260 265 270
Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr Ser 275
280 285 Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu
Pro 290 295 300 Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val
Ala Ser Gly 305 310 315 320 Gly Trp Asn Asp Val Ala Cys His Thr Thr
Met Tyr Phe Met Cys Glu 325 330 335 Phe Asp Lys Glu Asn Met 340
<210> SEQ ID NO 31 <211> LENGTH: 222 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(186) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 116-281 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(187)..(222) <223> OTHER INFORMATION: Collectin-11 neck
region (residues 116-151 of SEQ ID NO:22) <400> SEQUENCE: 31
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Gly Ser Thr Gly Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile
Thr 20 25 30 Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn
Ser Lys Asn 35 40 45 Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp
Glu Ser Ser Arg Ser 50 55 60 Gly His Ser Phe Leu Ser Asn Leu His
Leu Arg Asn Gly Glu Leu Val 65 70 75 80 Ile His Glu Lys Gly Phe Tyr
Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 85 90 95 Phe Gln Glu Glu Ile
Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 100 105 110
Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 115
120 125 Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly
Leu 130 135 140 Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu
Asn Asp Arg 145 150 155 160 Ile Phe Val Ser Val Thr Asn Glu His Leu
Ile Asp Met Asp His Glu 165 170 175 Ala Ser Phe Phe Gly Ala Phe Leu
Val Gly Ser Gln Leu Arg Lys Ala 180 185 190 Ile Gly Glu Met Asp Asn
Gln Val Ser Gln Leu Thr Ser Glu Leu Lys 195 200 205 Phe Ile Lys Asn
Ala Val Ala Gly Val Arg Glu Thr Glu Ser 210 215 220 <210> SEQ
ID NO 32 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Flag-epitope/enterokinase processing site
<400> SEQUENCE: 32 Asp Tyr Lys Asp Asp Asp Asp Lys Asp 1 5
<210> SEQ ID NO 33 <211> LENGTH: 54 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(1)..(1) <223> OTHER INFORMATION: Gly (when a=1, 2, 3, 4, 5,
or 6) or absent (when a=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (2)..(2) <223>
OTHER INFORMATION: Ser (when a=1, 2, 3, 4, 5, or 6) or absent (when
a=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (3)..(3) <223> OTHER INFORMATION: Ser
(when a=1, 2, 3, 4, 5, or 6) or absent (when a=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(4)..(4) <223> OTHER INFORMATION: Gly (when a=2, 3, 4, 5, or
6) or absent (when a=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (5)..(5) <223>
OTHER INFORMATION: Ser (when a=2, 3, 4, 5, or 6) or absent (when
a=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (6)..(6) <223> OTHER INFORMATION: Ser
(when a=2, 3, 4, 5, or 6) or absent (when a=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(7)..(7) <223> OTHER INFORMATION: Gly (when a=3, 4, 5, or 6)
or absent (when a=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (8)..(8) <223>
OTHER INFORMATION: Ser (when a=3, 4, 5, or 6) or absent (when a=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (9)..(9) <223> OTHER INFORMATION: Ser
(when a=3, 4, 5, or 6) or absent (when a=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: Gly (when a=4, 5, or 6)
or absent (when a=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Ser (when a=4, 5, or 6) or absent (when a=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (12)..(12) <223> OTHER INFORMATION: Ser
(when a=4, 5, or 6) or absent (when a=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Gly (when a=5 or 6) or
absent (when a=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Ser (when a=5 or 6) or absent (when a=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Ser
(when a=5 or 6) or absent (when a=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Gly (when a=6) or absent
(when a=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (17)..(17) <223>
OTHER INFORMATION: Ser (when a=6) or absent (when a=0, 1, 2, 3, 4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Ser
(when a=6) or absent (when a=0, 1, 2, 3, 4, or 5) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Ser (when b=1, 2, 3, 4,
5, or 6) or absent (when b=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Ser (when b=1, 2, 3, 4, 5, or 6) or absent (when
b=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Gly
(when b=1, 2, 3, 4, 5, or 6) or absent (when b=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(22)..(22) <223> OTHER INFORMATION: Ser (when b=2, 3, 4, 5,
or 6) or absent (when b=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (23)..(23) <223>
OTHER INFORMATION: Ser (when b=2, 3, 4, 5, or 6) or absent (when
b=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: Gly
(when b=2, 3, 4, 5, or 6) or absent (when b=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(25)..(25) <223> OTHER INFORMATION: Ser (when b=3, 4, 5, or
6) or absent (when b=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (26)..(26) <223>
OTHER INFORMATION: Ser (when b=3, 4, 5, or 6) or absent (when b=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Gly
(when b=3, 4, 5, or 6) or absent (when b=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(28)..(28) <223> OTHER INFORMATION: Ser (when b=4, 5, or 6)
or absent (when b=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (29)..(29) <223>
OTHER INFORMATION: Ser (when b=4, 5, or 6) or absent (when b=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (30)..(30) <223> OTHER INFORMATION: Gly
(when b=4, 5, or 6) or absent (when b=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(31)..(31) <223> OTHER INFORMATION: Ser (when b=5 or 6) or
absent (when b=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (32)..(32) <223>
OTHER INFORMATION: Ser (when b=5 or 6) or absent (when b=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (33)..(33) <223> OTHER INFORMATION: Gly
(when b=5 or 6) or absent (when b=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(34)..(34) <223> OTHER INFORMATION: Ser (when b=6) or absent
(when b=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (35)..(35) <223>
OTHER INFORMATION: Ser (when b=6) or absent (when b=0, 1, 2, 3,
4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (36)..(36) <223> OTHER INFORMATION: Gly
(when b=6) or absent (when b=0, 1, 2, 3, 4, or 5) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(37)..(37) <223> OTHER INFORMATION: Gly (when c=1, 2, 3, 4,
5, or 6) or absent (when c=0) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (38)..(38) <223>
OTHER INFORMATION: Ser (when c=1, 2, 3, 4, 5, or 6) or absent (when
c=0) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (39)..(39) <223> OTHER INFORMATION: Gly
(when c=1, 2, 3, 4, 5, or 6) or absent (when c=0) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(40)..(40) <223> OTHER INFORMATION: Gly (when c=2, 3, 4, 5,
or 6) or absent (when c=0 or 1) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: Ser (when c=2, 3, 4, 5, or 6) or absent (when
c=0 or 1) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (42)..(42) <223> OTHER INFORMATION: Gly
(when c=2, 3, 4, 5, or 6) or absent (when c=0 or 1) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(43)..(43) <223> OTHER INFORMATION: Gly (when c=3, 4, 5, or
6) or absent (when c=0, 1, or 2) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (44)..(44) <223>
OTHER INFORMATION: Ser (when c=3, 4, 5, or 6) or absent (when c=0,
1, or 2) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (45)..(45) <223> OTHER INFORMATION: Gly
(when c=3, 4, 5, or 6) or absent (when c=0, 1, or 2) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(46)..(46) <223> OTHER INFORMATION: Gly (when c=4, 5, or 6)
or absent (when c=0, 1, 2, or 3) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (47)..(47) <223>
OTHER INFORMATION: Ser (when c=4, 5, or 6) or absent (when c=0, 1,
2, or 3) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (48)..(48) <223> OTHER INFORMATION: Gly
(when c=4, 5, or 6) or absent (when c=0, 1, 2, or 3) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(49)..(49) <223> OTHER INFORMATION: Gly (when c=5 or 6) or
absent (when c=0, 1, 2, 3, or 4) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (50)..(50) <223>
OTHER INFORMATION: Ser (when c=5 or 6) or absent (when c=0, 1, 2,
3, or 4) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (51)..(51) <223> OTHER INFORMATION: Gly
(when c=5 or 6) or absent (when c=0, 1, 2, 3, or 4) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(52)..(52) <223> OTHER INFORMATION: Gly (when c=6) or absent
(when c=0, 1, 2, 3, 4, or 5) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (53)..(53) <223>
OTHER INFORMATION: Ser (when c=6) or absent (when c=0, 1, 2, 3, 4,
or 5) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (54)..(54) <223> OTHER INFORMATION: Gly
(when c=6) or absent (when c=0, 1, 2, 3, 4, or 5) <400>
SEQUENCE: 33 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Xaa Xaa Xaa Xaa Xaa Xaa 50
<210> SEQ ID NO 34 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <400>
SEQUENCE: 34 Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 1 5 10
<210> SEQ ID NO 35 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Flexible linker element <400>
SEQUENCE: 35 Gly Ser Ser Gly Ser Ser Gly Ser 1 5 <210> SEQ ID
NO 36 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Flexible linker element <400> SEQUENCE: 36
Gly Ser Ser Gly Ser 1 5 <210> SEQ ID NO 37 <211>
LENGTH: 825 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <300> PUBLICATION INFORMATION: <308> DATABASE
ACCESSION NUMBER: P24394 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(825)
<400> SEQUENCE: 37 Met Gly Trp Leu Cys Ser Gly Leu Leu Phe
Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly
Asn Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr
Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Asn Gly Pro Thr
Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe
Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 65 70 75 80
Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 85
90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp
Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala
Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Leu
Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu
Tyr Asn His Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu
Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 165 170 175 Val Thr Tyr Leu
Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 180 185 190 Ser Gly
Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 195 200 205
Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 210
215 220 Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val
Ser 225 230 235 240 Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr
Val Ser Ile Thr 245 250 255 Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile
Pro Asn Pro Ala Arg Ser 260 265 270 Arg Leu Val Ala Ile Ile Ile Gln
Asp Ala Gln Gly Ser Gln Trp Glu 275 280 285 Lys Arg Ser Arg Gly Gln
Glu Pro Ala Lys Cys Pro His Trp Lys Asn 290 295 300 Cys Leu Thr Lys
Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 305 310 315 320 Asp
Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 325 330
335 Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp
340 345 350 Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu
Ala Pro 355 360 365 Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu
Lys Gly Ser Phe
370 375 380 Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly
Arg Glu 385 390 395 400 Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe
Leu Asp Leu Leu Gly 405 410 415 Glu Glu Asn Gly Gly Phe Cys Gln Gln
Asp Met Gly Glu Ser Cys Leu 420 425 430 Leu Pro Pro Ser Gly Ser Thr
Ser Ala His Met Pro Trp Asp Glu Phe 435 440 445 Pro Ser Ala Gly Pro
Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 450 455 460 Leu His Leu
Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 465 470 475 480
Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 485
490 495 Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg
Glu 500 505 510 Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu
Val Glu Pro 515 520 525 Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro
Thr Thr Val Pro Gln 530 535 540 Pro Glu Pro Glu Thr Trp Glu Gln Ile
Leu Arg Arg Asn Val Leu Gln 545 550 555 560 His Gly Ala Ala Ala Ala
Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 565 570 575 Glu Phe Val His
Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 580 585 590 Val Gly
Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 595 600 605
Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 610
615 620 Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro
Gly 625 630 635 640 Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu
Phe Thr Phe Gly 645 650 655 Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln
Ser Ser His Leu Pro Ser 660 665 670 Ser Ser Pro Glu His Leu Gly Leu
Glu Pro Gly Glu Lys Val Glu Asp 675 680 685 Met Pro Lys Pro Pro Leu
Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 690 695 700 Asp Ser Leu Gly
Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 705 710 715 720 Cys
Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 725 730
735 Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser
740 745 750 Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro
Gly Gly 755 760 765 Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu
Ala Pro Ser Gly 770 775 780 Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser
Phe His Pro Ala Pro Gly 785 790 795 800 Asn Ala Gln Ser Ser Ser Gln
Thr Pro Lys Ile Val Asn Phe Val Ser 805 810 815 Val Gly Pro Thr Tyr
Met Arg Val Ser 820 825 <210> SEQ ID NO 38 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Strep-tag II <400> SEQUENCE: 38 Trp Ser His Pro Gln Phe Glu
Lys 1 5 <210> SEQ ID NO 39 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Affinity tag linker element
<400> SEQUENCE: 39 Pro Ser Ser Ser Ser Ser Ser Ala 1 5
<210> SEQ ID NO 40 <211> LENGTH: 346 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(160) <223> OTHER INFORMATION: CD95L receptor
binding domain (residues 142-281 of SEQ ID NO:6) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(161)..(171) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (172)..(327) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 220-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (172)..(209) <223> OTHER INFORMATION:
SP-D neck region (residues 220-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(210)..(327) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (328)..(338) <223> OTHER
INFORMATION: Affinity tag linker element (SEQ ID NO:54) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(339)..(346) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 40 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu Leu Arg
Lys Val Ala His Leu Thr Gly Lys Ser 20 25 30 Asn Ser Arg Ser Met
Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val 35 40 45 Leu Leu Ser
Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu 50 55 60 Thr
Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser 65 70
75 80 Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser
Lys 85 90 95 Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met
Ser Tyr Cys 100 105 110 Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr
Val Gly Ala Val Phe 115 120 125 Asn Leu Thr Ser Ala Asp His Leu Tyr
Val Asn Val Ser Glu Leu Ser 130 135 140 Leu Val Asn Phe Glu Glu Ser
Gln Thr Phe Phe Gly Leu Tyr Lys Leu 145 150 155 160 Gly Ser Ser Gly
Ser Ser Gly Ser Ser Gly Ser Gly Leu Pro Asp Val 165 170 175 Ala Ser
Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 180 185 190
Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 195
200 205 Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val
Lys 210 215 220 Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly
Gly Gln Leu 225 230 235 240 Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala
Ala Leu Gln Gln Leu Val 245 250 255 Val Ala Lys Asn Glu Ala Ala Phe
Leu Ser Met Thr Asp Ser Lys Thr 260 265 270 Glu Gly Lys Phe Thr Tyr
Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 275 280 285 Trp Ala Pro Gly
Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 290 295 300 Glu Ile
Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 305 310 315
320 Arg Leu Val Val Cys Glu Phe Gly Gly Ser Pro Ser Ser Ser Ser Ser
325 330 335 Ser Ala Trp Ser His Pro Gln Phe Glu Lys 340 345
<210> SEQ ID NO 41 <211> LENGTH: 356 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 2 (SEQ ID NO:24)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(170) <223> OTHER INFORMATION: LIGHT receptor
binding domain (residues 91-240 of SEQ ID NO:16) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(171)..(181) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (182)..(337)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 220-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (182)..(219)
<223> OTHER INFORMATION: SP-D neck region (residues 220-257
of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (220)..(337) <223> OTHER
INFORMATION: SP-D CRD (residues 258-375 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (338)..(348) <223> OTHER INFORMATION: Affinity tag
linker element 2 (SEQ ID NO:54) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (349)..(356)
<223> OTHER INFORMATION: Strep-tag II (SEQ ID NO:38)
<400> SEQUENCE: 41 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu Val Asn Pro
Ala Ala His Leu Thr Gly Ala Asn 20 25 30 Ser Ser Leu Thr Gly Ser
Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 35 40 45 Gly Leu Ala Phe
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 50 55 60 Val Thr
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 65 70 75 80
Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 85
90 95 Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val
Ser 100 105 110 Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg
Val Trp Trp 115 120 125 Asp Ser Ser Phe Leu Gly Gly Val Val His Leu
Glu Ala Gly Glu Glu 130 135 140 Val Val Val Arg Val Leu Asp Glu Arg
Leu Val Arg Leu Arg Asp Gly 145 150 155 160 Thr Arg Ser Tyr Phe Gly
Ala Phe Met Val Gly Ser Ser Gly Ser Ser 165 170 175 Gly Ser Ser Gly
Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln 180 185 190 Val Glu
Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser 195 200 205
Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu 210
215 220 Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu Ala
Gln 225 230 235 240 Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser
Pro Arg Ser Ala 245 250 255 Ala Glu Asn Ala Ala Leu Gln Gln Leu Val
Val Ala Lys Asn Glu Ala 260 265 270 Ala Phe Leu Ser Met Thr Asp Ser
Lys Thr Glu Gly Lys Phe Thr Tyr 275 280 285 Pro Thr Gly Glu Ser Leu
Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro 290 295 300 Asn Asp Asp Gly
Gly Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly 305 310 315 320 Lys
Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu 325 330
335 Phe Gly Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro
340 345 350 Gln Phe Glu Lys 355 <210> SEQ ID NO 42
<211> LENGTH: 1129 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Expression cassette for TRAIL-SPD fusion protein
3 (SEQ ID NO:43) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(6) <223> OTHER
INFORMATION: HindIII restriction site <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (16)..(18)
<223> OTHER INFORMATION: Start codon <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(559)..(564) <223> OTHER INFORMATION: BamHI restriction site
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1122)..(1129) <223> OTHER INFORMATION: NotI
restriction site <400> SEQUENCE: 42 aagcttgccg ccaccatgga
gaccgataca ctgctcttgt gggtgctctt gctgtgggtt 60 cctgcaggta
atggtcaaag agtcgcagct cacatcactg ggactagagg caggagtaac 120
accctgagtt ctcccaattc caagaacgag aaagccctgg gtaggaagat caactcctgg
180 gaaagctcca gaagcggcca tagctttctt agcaacctcc acttgaggaa
tggcgaactt 240 gtgatccatg agaagggctt ctactacatc tacagccaga
cgtacttcag gttccaggag 300 gaaatcaagg agaacaccaa gaacgacaag
cagatggtgc aatacatcta caagtacacg 360 tcataccctg atcctatact
gctgatgaag tccgccagaa acagttgctg gagcaaagac 420 gctgaatacg
gcctgtattc catctatcag ggcggtatct ttgaactcaa ggagaacgac 480
aggatcttcg tgtctgtgac aaacgagcat ctgatcgaca tggaccatga agcgtctttc
540 ttcggtgcct tcttggtggg atcctctggt tcgagtggtt cgagtggttc
tggattgcca 600 gacgttgctt ctttgagaca acaggttgag gctttgcagg
gtcaagtcca gcacttgcag 660 gctgctttct ctcaatacaa gaaggttgag
ttgttcccaa acggtcaatc tgttggcgaa 720 aagattttca agactgctgg
tttcgtcaaa ccattcacgg aggcacaatt attgtgtact 780 caggctggtg
gacagttggc ctctccacgt tctgccgctg agaacgccgc cttgcaacag 840
ttggtcgtag ctaagaacga ggctgctttc ttgagcatga ctgattccaa gacagagggc
900 aagttcacct acccaacagg agaatccttg gtctattcta attgggcacc
tggagagccc 960 aacgatgatg gcggctcaga ggactgtgtg gaaatcttca
ccaatggcaa gtggaatgac 1020 agagcttgtg gagagaagcg tttggtggtc
tgtgagttcg gaggcagtcc ttcatcttca 1080 tctagctctg cctggtcgca
tccacaattc gagaaataat agcggccgc 1129 <210> SEQ ID NO 43
<211> LENGTH: 367 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(181) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 120-280 of SEQ ID NO:10) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(348) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 220-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(230) <223> OTHER INFORMATION:
SP-D neck region (residues 220-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(231)..(348) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (349)..(359) <223> OTHER
INFORMATION: Affinity tag linker element 2 (SEQ ID NO:54)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (360)..(367) <223> OTHER INFORMATION: Strep-tag II
(SEQ ID NO:38) <400> SEQUENCE: 43 Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn
Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly
Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55
60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys
65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln
Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val
Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu
Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn
Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly
Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185
190 Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
195 200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val 210 215 220
Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr 225
230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys
Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala
Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val Val Ala Lys Asn Glu
Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser Lys Thr Glu Gly Lys
Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu Val Tyr Ser Asn Trp
Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310 315 320 Ser Glu Asp
Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg 325 330 335 Ala
Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly Gly Ser Pro 340 345
350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 355
360 365 <210> SEQ ID NO 44 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Fusion protein
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Signal peptide 3
(SEQ ID NO:25) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (21)..(181) <223> OTHER
INFORMATION: TRAIL receptor binding domain (residues 120-280 of SEQ
ID NO:10) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (182)..(192) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (193)..(230)
<223> OTHER INFORMATION: SP-D neck region (residues 220-257
of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (231)..(238) <223> OTHER
INFORMATION: Affinity tag linker element (SEQ ID NO:39) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(239)..(246) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 44 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val
Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu
Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70
75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu
Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln
Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu
Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu
Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu
Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu
His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala
Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185 190
Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln 195
200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys
Val 210 215 220 Glu Leu Phe Pro Asn Gly Pro Ser Ser Ser Ser Ser Ser
Ala Trp Ser 225 230 235 240 His Pro Gln Phe Glu Lys 245 <210>
SEQ ID NO 45 <211> LENGTH: 365 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(181) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 120-280 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(347) <223> OTHER INFORMATION:
Collectin-11 colletin trimerization domain (residues 117-271 of SEQ
ID NO:22) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(224) <223> OTHER INFORMATION:
Collectin-11 neck region (residues 117-148 of SEQ ID NO:22)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (225)..(347) <223> OTHER INFORMATION: Collectin-11
CRD (residues 149-271 of SEQ ID NO:22) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(348)..(357) <223> OTHER INFORMATION: Affinity tag linker
element 3 (SEQ ID NO:55) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (358)..(365) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 45
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg
Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu
Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg
Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly
Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser
Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr
Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135
140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser
145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala
Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser Ser
Gly Ser Ser Gly Ser 180 185 190 Gln Leu Arg Lys Ala Ile Gly Glu Met
Asp Asn Gln Val Ser Gln Leu 195 200 205 Thr Ser Glu Leu Lys Phe Ile
Lys Asn Ala Val Ala Gly Val Arg Glu 210 215 220 Thr Glu Ser Lys Ile
Tyr Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala 225 230 235 240 Asp Ala
Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser Met Pro 245 250 255
Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala 260
265 270 Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu
Gly 275 280 285 Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe
Asn Lys Trp 290 295 300 Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu
Glu Asp Cys Val Glu 305 310 315 320 Met Val Ala Ser Gly Gly Trp Asn
Asp Val Ala Cys His Thr Thr Met 325 330 335 Tyr Phe Met Cys Glu Phe
Asp Lys Glu Asn Met Gly Ser Pro Ser Ser 340 345 350 Ser Ser Ser Ser
Ala Trp Ser His Pro Gln Phe Glu Lys 355 360 365 <210> SEQ ID
NO 46 <211> LENGTH: 246 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Fusion protein <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(21)..(181) <223> OTHER INFORMATION: TRAIL receptor binding
domain (residues 120-280 of SEQ ID NO:10)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (182)..(193) <223> OTHER INFORMATION: Flexible
linker E (SEQ ID NO:56) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (194)..(229) <223> OTHER
INFORMATION: Collectin-11 neck region (residues 116-151 of SEQ ID
NO:22) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (230)..(238) <223> OTHER INFORMATION:
Affinity tag linker element 4 (SEQ ID NO:57) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(239)..(246) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 46 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val
Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu
Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70
75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu
Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln
Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu
Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu
Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu
Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu
His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala
Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185 190
Gly Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 195
200 205 Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly
Val 210 215 220 Arg Glu Thr Glu Ser Gly Pro Ser Ser Ser Ser Ser Ser
Ala Trp Ser 225 230 235 240 His Pro Gln Phe Glu Lys 245 <210>
SEQ ID NO 47 <211> LENGTH: 367 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(181) <223> OTHER INFORMATION: TRAIL mutant 1
receptor binding domain (residues 120-280 of SEQ ID NO:10 with
Y189A, Q193S, N199V, K201R, Y213W, S215D) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(348) <223> OTHER INFORMATION:
SP-D collectin trimerization domain (residues 220-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(230) <223> OTHER INFORMATION:
SP-D neck region (residues 220-257 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(231)..(348) <223> OTHER INFORMATION: SP-D CRD (residues
258-375 of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (349)..(359) <223> OTHER
INFORMATION: Affinity tag linker element 2 (SEQ ID NO:54)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (360)..(367) <223> OTHER INFORMATION: Strep-tag II
(SEQ ID NO:38) <400> SEQUENCE: 47 Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn
Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly
Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55
60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys
65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Ala Phe Arg Phe Ser
Glu Glu 85 90 95 Ile Lys Glu Val Thr Arg Asn Asp Lys Gln Met Val
Gln Tyr Ile Tyr 100 105 110 Lys Trp Thr Asp Tyr Pro Asp Pro Ile Leu
Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn
Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly
Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185
190 Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
195 200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val 210 215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys
Ile Phe Lys Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu
Ala Gln Leu Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser
Pro Arg Ser Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val
Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser
Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu
Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310
315 320 Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp
Arg 325 330 335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly
Gly Ser Pro 340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro
Gln Phe Glu Lys 355 360 365 <210> SEQ ID NO 48 <211>
LENGTH: 367 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(181)
<223> OTHER INFORMATION: TRAIL mutant 2 receptor binding
domain (residues 120-280 of SEQ ID NO:10 with Y189Q, R191K, Q193R,
H264R, I266L, D267Q) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (182)..(192) <223> OTHER
INFORMATION: Flexible linker A (SEQ ID NO:34) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(193)..(348) <223> OTHER INFORMATION: SP-D collectin
trimerization domain (residues 220-375 of SEQ ID NO:21) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(193)..(230) <223> OTHER INFORMATION: SP-D neck region
(residues 220-257 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (231)..(348)
<223> OTHER INFORMATION: SP-D CRD (residues 258-375 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (349)..(359) <223> OTHER INFORMATION:
Affinity tag linker element 2 (SEQ ID NO:54) <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(360)..(367) <223> OTHER INFORMATION: Strep-tag II (SEQ ID
NO:38) <400> SEQUENCE: 48 Met Glu Thr Asp Thr Leu Leu Leu Trp
Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val
Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60
Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65
70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Gln Phe Lys Phe Arg
Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val
Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu
Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn
Glu Arg Leu Leu Gln Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly
Ala Phe Leu Val Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 180 185
190 Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln
195 200 205 Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys
Lys Val 210 215 220 Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys
Ile Phe Lys Thr 225 230 235 240 Ala Gly Phe Val Lys Pro Phe Thr Glu
Ala Gln Leu Leu Cys Thr Gln 245 250 255 Ala Gly Gly Gln Leu Ala Ser
Pro Arg Ser Ala Ala Glu Asn Ala Ala 260 265 270 Leu Gln Gln Leu Val
Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met 275 280 285 Thr Asp Ser
Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser 290 295 300 Leu
Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly 305 310
315 320 Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp
Arg 325 330 335 Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe Gly
Gly Ser Pro 340 345 350 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro
Gln Phe Glu Lys 355 360 365 <210> SEQ ID NO 49 <211>
LENGTH: 367 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion
protein <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Signal peptide 3 (SEQ ID NO:25) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (21)..(181)
<223> OTHER INFORMATION: TRAIL receptor binding domain
(residues 120-280 of SEQ ID NO:10) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (182)..(192)
<223> OTHER INFORMATION: Flexible linker A (SEQ ID NO:34)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (193)..(348) <223> OTHER INFORMATION: SP-D mutant 1
collectin trimerization domain (residues 220-375 of SEQ ID NO:21
with F355A) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(230) <223> OTHER INFORMATION:
SP-D mutant 1 neck region (residues 220-257 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (231)..(348) <223> OTHER INFORMATION: SP-D mutant 1
CRD (residues 258-375 of SEQ ID NO:21 with F355A) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(349)..(359) <223> OTHER INFORMATION: Affinity tag linker
element 2 (SEQ ID NO:54) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (360)..(367) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 49
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg
Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu
Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg
Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly
Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser
Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr
Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135
140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser
145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala
Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser Ser
Gly Ser Ser Gly Ser 180 185 190 Gly Leu Pro Asp Val Ala Ser Leu Arg
Gln Gln Val Glu Ala Leu Gln 195 200 205 Gly Gln Val Gln His Leu Gln
Ala Ala Phe Ser Gln Tyr Lys Lys Val 210 215 220 Glu Leu Phe Pro Asn
Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr 225 230 235 240 Ala Gly
Phe Val Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln 245 250 255
Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala 260
265 270 Leu Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe Leu Ser
Met 275 280 285 Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr
Gly Glu Ser 290 295 300 Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro
Asn Asp Asp Gly Gly 305 310 315 320 Ser Glu Asp Cys Val Glu Ile Ala
Thr Asn Gly Lys Trp Asn Asp Arg 325 330 335 Ala Cys Gly Glu Lys Arg
Leu Val Val Cys Glu Phe Gly Gly Ser Pro 340 345 350 Ser Ser Ser Ser
Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 355 360 365 <210>
SEQ ID NO 50 <211> LENGTH: 367 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(181) <223> OTHER INFORMATION: TRAIL receptor
binding domain (residues 120-280 of SEQ ID NO:10) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(182)..(192) <223> OTHER INFORMATION: Flexible linker A (SEQ
ID NO:34) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (193)..(348) <223> OTHER INFORMATION:
SP-D mutant 2 collectin trimerization domain (residues 220-375 of
SEQ ID NO:21 with F355D) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (193)..(230) <223> OTHER
INFORMATION: SP-D mutant 2 neck region (residues 220-257 of SEQ ID
NO:21) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (231)..(348) <223> OTHER INFORMATION:
SP-D mutant 2 CRD (residues 258-375 of SEQ ID NO:21 with F355D)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (349)..(359) <223> OTHER INFORMATION: Affinity tag
linker element 2 (SEQ ID NO:54) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (360)..(367)
<223> OTHER INFORMATION: Strep-tag II (SEQ ID NO:38)
<400> SEQUENCE: 50 Met Glu Thr Asp Thr Leu Leu Leu Trp Val
Leu Leu Leu Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala
Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser
Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile
Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80
Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85
90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile
Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys
Ser Ala Arg 115 120 125
Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130
135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val
Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu
Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Ser Ser Gly Ser
Ser Gly Ser Ser Gly Ser 180 185 190 Gly Leu Pro Asp Val Ala Ser Leu
Arg Gln Gln Val Glu Ala Leu Gln 195 200 205 Gly Gln Val Gln His Leu
Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val 210 215 220 Glu Leu Phe Pro
Asn Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr 225 230 235 240 Ala
Gly Phe Val Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln 245 250
255 Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala
260 265 270 Leu Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe Leu
Ser Met 275 280 285 Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro
Thr Gly Glu Ser 290 295 300 Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu
Pro Asn Asp Asp Gly Gly 305 310 315 320 Ser Glu Asp Cys Val Glu Ile
Asp Thr Asn Gly Lys Trp Asn Asp Arg 325 330 335 Ala Cys Gly Glu Lys
Arg Leu Val Val Cys Glu Phe Gly Gly Ser Pro 340 345 350 Ser Ser Ser
Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 355 360 365
<210> SEQ ID NO 51 <211> LENGTH: 344 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(158) <223> OTHER INFORMATION: APRIL version
2 receptor binding domain (residues 113-250 of SEQ ID NO:14)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (159)..(169) <223> OTHER INFORMATION: Flexible
linker A (SEQ ID NO:34) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (170)..(325) <223> OTHER
INFORMATION: SP-D collectin trimerization domain (residues 220-375
of SEQ ID NO:21) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (170)..(207) <223> OTHER
INFORMATION: SP-D neck region (residues 220-257 of SEQ ID NO:21)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (208)..(325) <223> OTHER INFORMATION: SP-D CRD
(residues 258-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (326)..(336)
<223> OTHER INFORMATION: Affinity tag linker element 2 (SEQ
ID NO:54) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (337)..(344) <223> OTHER INFORMATION:
Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 51 Met Glu Thr
Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala
Gly Asn Gly Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn 20 25
30 Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro
35 40 45 Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly
Val Arg 50 55 60 Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln
Val Leu Phe Gln 65 70 75 80 Asp Val Thr Phe Thr Met Gly Gln Val Val
Ser Arg Glu Gly Gln Gly 85 90 95 Arg Gln Glu Thr Leu Phe Arg Cys
Ile Arg Ser Met Pro Ser His Pro 100 105 110 Asp Arg Ala Tyr Asn Ser
Cys Tyr Ser Ala Gly Val Phe His Leu His 115 120 125 Gln Gly Asp Ile
Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 130 135 140 Asn Leu
Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Gly Ser 145 150 155
160 Ser Gly Ser Ser Gly Ser Ser Gly Ser Gly Leu Pro Asp Val Ala Ser
165 170 175 Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His
Leu Gln 180 185 190 Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe
Pro Asn Gly Gln 195 200 205 Ser Val Gly Glu Lys Ile Phe Lys Thr Ala
Gly Phe Val Lys Pro Phe 210 215 220 Thr Glu Ala Gln Leu Leu Cys Thr
Gln Ala Gly Gly Gln Leu Ala Ser 225 230 235 240 Pro Arg Ser Ala Ala
Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala 245 250 255 Lys Asn Glu
Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly 260 265 270 Lys
Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala 275 280
285 Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile
290 295 300 Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys
Arg Leu 305 310 315 320 Val Val Cys Glu Phe Gly Gly Ser Pro Ser Ser
Ser Ser Ser Ser Ala 325 330 335 Trp Ser His Pro Gln Phe Glu Lys 340
<210> SEQ ID NO 52 <211> LENGTH: 450 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(140) <223> OTHER INFORMATION: Variable
domain heavy chain <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (141)..(155) <223> OTHER
INFORMATION: Flexible linker element F (SEQ ID NO:58) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(156)..(264) <223> OTHER INFORMATION: Variable domain light
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (265)..(275) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (276)..(431)
<223> OTHER INFORMATION: SP-D collectin trimerization domain
(residues 220-375 of SEQ ID NO:21) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (432)..(441)
<223> OTHER INFORMATION: Affinity tag linker element 2 (SEQ
ID NO:54) <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (442)..(450) <223> OTHER INFORMATION:
Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 52 Met Glu Thr
Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Ala
Gly Asn Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 20 25
30 Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
35 40 45 Phe Asn Thr Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly
Lys Gly 50 55 60 Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn
Asn Tyr Ala Thr 65 70 75 80 Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe
Thr Leu Ser Arg Asp Asp 85 90 95 Ser Lys Asn Thr Leu Tyr Leu Gln
Met Asn Ser Leu Lys Thr Glu Asp 100 105 110 Thr Ala Val Tyr Tyr Cys
Thr Arg Asp Arg Gly Trp Gly Ala Met Asp 115 120 125 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 130 135 140 Ser Gly
Gly Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr 145 150 155
160 Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
165 170 175 Thr Cys Ser Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn Trp
Tyr Gln 180 185 190 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
Tyr Thr Ser Ser 195 200 205 Leu His Ser Gly Val Pro Ser Arg Phe Ser
Gly Ser Gly Ser Gly Thr 210 215 220 Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro Glu Asp Phe Ala Thr 225 230 235 240
Tyr Tyr Cys Gln Gln Phe Ser Asn Leu Pro Trp Thr Phe Gly Gly Gly 245
250 255 Thr Lys Leu Glu Ile Lys Arg Thr Gly Ser Ser Gly Ser Ser Gly
Ser 260 265 270 Ser Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln
Gln Val Glu 275 280 285 Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala
Ala Phe Ser Gln Tyr 290 295 300 Lys Lys Val Glu Leu Phe Pro Asn Gly
Gln Ser Val Gly Glu Lys Ile 305 310 315 320 Phe Lys Thr Ala Gly Phe
Val Lys Pro Phe Thr Glu Ala Gln Leu Leu 325 330 335 Cys Thr Gln Ala
Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu 340 345 350 Asn Ala
Ala Leu Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe 355 360 365
Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr 370
375 380 Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn
Asp 385 390 395 400 Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr
Asn Gly Lys Trp 405 410 415 Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu
Val Val Cys Glu Phe Gly 420 425 430 Gly Ser Pro Ser Ser Ser Ser Ser
Ser Ala Trp Ser His Pro Gln Phe 435 440 445 Glu Lys 450 <210>
SEQ ID NO 53 <211> LENGTH: 450 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Fusion protein <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Signal peptide 3 (SEQ ID NO:25)
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (21)..(140) <223> OTHER INFORMATION: Variable
domain heavy chain <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (141)..(155) <223> OTHER
INFORMATION: Flexible linker element F (SEQ ID NO:58) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(156)..(264) <223> OTHER INFORMATION: Variable domain light
chain <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (265)..(275) <223> OTHER INFORMATION:
Flexible linker A (SEQ ID NO:34) <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (276)..(431)
<223> OTHER INFORMATION: SP-D mutant collectin trimerization
domain (residues 220-375 of SEQ ID NO:21 with F355D) <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(432)..(441) <223> OTHER INFORMATION: Affinity tag linker
element (SEQ ID NO:54) <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (442)..(450) <223> OTHER
INFORMATION: Strep-tag II (SEQ ID NO:38) <400> SEQUENCE: 53
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Ala Gly Asn Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val 20 25 30 Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr 35 40 45 Phe Asn Thr Asn Ala Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly 50 55 60 Leu Glu Trp Val Ala Arg Ile Arg Ser
Lys Ser Asn Asn Tyr Ala Thr 65 70 75 80 Tyr Tyr Ala Asp Ser Val Lys
Asp Arg Phe Thr Leu Ser Arg Asp Asp 85 90 95 Ser Lys Asn Thr Leu
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 100 105 110 Thr Ala Val
Tyr Tyr Cys Thr Arg Asp Arg Gly Trp Gly Ala Met Asp 115 120 125 Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 130 135
140 Ser Gly Gly Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr
145 150 155 160 Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
Val Thr Ile 165 170 175 Thr Cys Ser Ala Ser Gln Asp Ile Asn Asn Tyr
Leu Asn Trp Tyr Gln 180 185 190 Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile Tyr Tyr Thr Ser Ser 195 200 205 Leu His Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr 210 215 220 Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 225 230 235 240 Tyr Tyr
Cys Gln Gln Phe Ser Asn Leu Pro Trp Thr Phe Gly Gly Gly 245 250 255
Thr Lys Leu Glu Ile Lys Arg Thr Gly Ser Ser Gly Ser Ser Gly Ser 260
265 270 Ser Gly Ser Gly Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val
Glu 275 280 285 Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe
Ser Gln Tyr 290 295 300 Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser
Val Gly Glu Lys Ile 305 310 315 320 Phe Lys Thr Ala Gly Phe Val Lys
Pro Phe Thr Glu Ala Gln Leu Leu 325 330 335 Cys Thr Gln Ala Gly Gly
Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu 340 345 350 Asn Ala Ala Leu
Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe 355 360 365 Leu Ser
Met Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr 370 375 380
Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp 385
390 395 400 Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Asp Thr Asn Gly
Lys Trp 405 410 415 Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val
Cys Glu Phe Gly 420 425 430 Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala
Trp Ser His Pro Gln Phe 435 440 445 Glu Lys 450 <210> SEQ ID
NO 54 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Affinity tag linker element <400>
SEQUENCE: 54 Gly Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala 1 5 10
<210> SEQ ID NO 55 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Affinity tag linker element
<400> SEQUENCE: 55 Gly Ser Pro Ser Ser Ser Ser Ser Ser Ala 1
5 10 <210> SEQ ID NO 56 <211> LENGTH: 12 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Flexible linker element
<400> SEQUENCE: 56 Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly
Ser Gly 1 5 10 <210> SEQ ID NO 57 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Affinity tag
linker element <400> SEQUENCE: 57 Gly Pro Ser Ser Ser Ser Ser
Ser Ala 1 5 <210> SEQ ID NO 58 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Flexible linker
element <400> SEQUENCE: 58 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Thr Gly 1 5 10 15 <210> SEQ ID NO 59
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: Q8IWL2 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(248)
<400> SEQUENCE: 59 Met Trp Leu Cys Pro Leu Ala Leu Asn Leu
Ile Leu Met Ala Ala Ser
1 5 10 15 Gly Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro
Gly Ile 20 25 30 Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg
Asp Gly Arg Asp 35 40 45 Gly Leu Lys Gly Asp Pro Gly Pro Pro Gly
Pro Met Gly Pro Pro Gly 50 55 60 Glu Met Pro Cys Pro Pro Gly Asn
Asp Gly Leu Pro Gly Ala Pro Gly 65 70 75 80 Ile Pro Gly Glu Cys Gly
Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro 85 90 95 Pro Gly Leu Pro
Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 100 105 110 Asp Phe
Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 115 120 125
Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 130
135 140 Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly
Gly 145 150 155 160 Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu
Ala Ile Ala Ser 165 170 175 Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr
Val Gly Leu Thr Glu Gly 180 185 190 Pro Ser Pro Gly Asp Phe Arg Tyr
Ser Asp Gly Thr Pro Val Asn Tyr 195 200 205 Thr Asn Trp Tyr Arg Gly
Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 210 215 220 Val Glu Met Tyr
Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 225 230 235 240 Ser
Arg Leu Thr Ile Cys Glu Phe 245 <210> SEQ ID NO 60
<211> LENGTH: 248 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <300> PUBLICATION INFORMATION: <308>
DATABASE ACCESSION NUMBER: Q8IWL1 <309> DATABASE ENTRY DATE:
2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(248)
<400> SEQUENCE: 60 Met Trp Leu Cys Pro Leu Ala Leu Asn Leu
Ile Leu Met Ala Ala Ser 1 5 10 15 Gly Ala Ala Cys Glu Val Lys Asp
Val Cys Val Gly Ser Pro Gly Ile 20 25 30 Pro Gly Thr Pro Gly Ser
His Gly Leu Pro Gly Arg Asp Gly Arg Asp 35 40 45 Gly Val Lys Gly
Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 50 55 60 Glu Thr
Pro Cys Pro Pro Gly Asn Asn Gly Leu Pro Gly Ala Pro Gly 65 70 75 80
Val Pro Gly Glu Arg Gly Glu Lys Gly Glu Ala Gly Glu Arg Gly Pro 85
90 95 Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu
His 100 105 110 Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu
Ser Leu Gln 115 120 125 Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe
Ser Ser Asn Gly Gln 130 135 140 Ser Ile Thr Phe Asp Ala Ile Gln Glu
Ala Cys Ala Arg Ala Gly Gly 145 150 155 160 Arg Ile Ala Val Pro Arg
Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 165 170 175 Phe Val Lys Lys
Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 180 185 190 Pro Ser
Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 195 200 205
Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 210
215 220 Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu
Tyr 225 230 235 240 Ser Arg Leu Thr Ile Cys Glu Phe 245 <210>
SEQ ID NO 61 <211> LENGTH: 248 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <300> PUBLICATION
INFORMATION: <308> DATABASE ACCESSION NUMBER: P11226
<309> DATABASE ENTRY DATE: 2008-12-16 <313> RELEVANT
RESIDUES IN SEQ ID NO: (1)..(248) <400> SEQUENCE: 61 Met Ser
Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 1 5 10 15
Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 20
25 30 Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro
Gly 35 40 45 Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu
Pro Gly Gln 50 55 60 Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys
Leu Gly Pro Pro Gly 65 70 75 80 Asn Pro Gly Pro Ser Gly Ser Pro Gly
Pro Lys Gly Gln Lys Gly Asp 85 90 95 Pro Gly Lys Ser Pro Asp Gly
Asp Ser Ser Leu Ala Ala Ser Glu Arg 100 105 110 Lys Ala Leu Gln Thr
Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 115 120 125 Ser Leu Gly
Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 130 135 140 Ile
Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 145 150
155 160 Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln
Asn 165 170 175 Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu
Lys Thr Glu 180 185 190 Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu
Thr Tyr Thr Asn Trp 195 200 205 Asn Glu Gly Glu Pro Asn Asn Ala Gly
Ser Asp Glu Asp Cys Val Leu 210 215 220 Leu Leu Lys Asn Gly Gln Trp
Asn Asp Val Pro Cys Ser Thr Ser His 225 230 235 240 Leu Ala Val Cys
Glu Phe Pro Ile 245 <210> SEQ ID NO 62 <211> LENGTH:
277 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<300> PUBLICATION INFORMATION: <308> DATABASE ACCESSION
NUMBER: Q9Y6Z7 <309> DATABASE ENTRY DATE: 2008-12-16
<313> RELEVANT RESIDUES IN SEQ ID NO: (1)..(277) <400>
SEQUENCE: 62 Met Asn Gly Phe Ala Ser Leu Leu Arg Arg Asn Gln Phe
Ile Leu Leu 1 5 10 15 Val Leu Phe Leu Leu Gln Ile Gln Ser Leu Gly
Leu Asp Ile Asp Ser 20 25 30 Arg Pro Thr Ala Glu Val Cys Ala Thr
His Thr Ile Ser Pro Gly Pro 35 40 45 Lys Gly Asp Asp Gly Glu Lys
Gly Asp Pro Gly Glu Glu Gly Lys His 50 55 60 Gly Lys Val Gly Arg
Met Gly Pro Lys Gly Ile Lys Gly Glu Leu Gly 65 70 75 80 Asp Met Gly
Asp Gln Gly Asn Ile Gly Lys Thr Gly Pro Ile Gly Lys 85 90 95 Lys
Gly Asp Lys Gly Glu Lys Gly Leu Leu Gly Ile Pro Gly Glu Lys 100 105
110 Gly Lys Ala Gly Thr Val Cys Asp Cys Gly Arg Tyr Arg Lys Phe Val
115 120 125 Gly Gln Leu Asp Ile Ser Ile Ala Arg Leu Lys Thr Ser Met
Lys Phe 130 135 140 Val Lys Asn Val Ile Ala Gly Ile Arg Glu Thr Glu
Glu Lys Phe Tyr 145 150 155 160 Tyr Ile Val Gln Glu Glu Lys Asn Tyr
Arg Glu Ser Leu Thr His Cys 165 170 175 Arg Ile Arg Gly Gly Met Leu
Ala Met Pro Lys Asp Glu Ala Ala Asn 180 185 190 Thr Leu Ile Ala Asp
Tyr Val Ala Lys Ser Gly Phe Phe Arg Val Phe 195 200 205 Ile Gly Val
Asn Asp Leu Glu Arg Glu Gly Gln Tyr Met Phe Thr Asp 210 215 220 Asn
Thr Pro Leu Gln Asn Tyr Ser Asn Trp Asn Glu Gly Glu Pro Ser 225 230
235 240 Asp Pro Tyr Gly His Glu Asp Cys Val Glu Met Leu Ser Ser Gly
Arg 245 250 255 Trp Asn Asp Thr Glu Cys His Leu Thr Met Tyr Phe Val
Cys Glu Phe 260 265 270 Ile Lys Lys Lys Lys 275 <210> SEQ ID
NO 63 <211> LENGTH: 742 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <300> PUBLICATION INFORMATION:
<308> DATABASE ACCESSION NUMBER: Q5KU26 <309> DATABASE
ENTRY DATE: 2008-12-16 <313> RELEVANT RESIDUES IN SEQ ID NO:
(1)..(742) <400> SEQUENCE: 63 Met Lys Asp Asp Phe Ala Glu Glu
Glu Glu Val Gln Ser Phe Gly Tyr 1 5 10 15 Lys Arg Phe Gly Ile Gln
Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 20 25 30
Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 35
40 45 Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu
Lys 50 55 60 Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln
Thr Tyr Asp 65 70 75 80 Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys
Lys Leu Gly Asp Gln 85 90 95 Thr Gly Lys Lys Ala Ile Ser Thr Asn
Ser Glu Leu Ser Thr Phe Arg 100 105 110 Ser Asp Ile Leu Asp Leu Arg
Gln Gln Leu Arg Glu Ile Thr Glu Lys 115 120 125 Thr Ser Lys Asn Lys
Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 130 135 140 Ala Leu Val
Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 145 150 155 160
Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 165
170 175 Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn
Leu 180 185 190 Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn
Leu Asn Asn 195 200 205 Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu
Ile Thr Asn Leu Gln 210 215 220 Arg Ser Val Asp Asp Thr Ser Gln Ala
Ile Gln Arg Ile Lys Asn Asp 225 230 235 240 Phe Gln Asn Leu Gln Gln
Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 245 250 255 Trp Leu Lys Glu
Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 260 265 270 Ser Ala
Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 275 280 285
Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 290
295 300 Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys
Asp 305 310 315 320 Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu
Glu Glu Arg Phe 325 330 335 Gln Leu Phe Glu Thr Asp Ile Val Asn Ile
Ile Ser Asn Ile Ser Tyr 340 345 350 Thr Ala His His Leu Arg Thr Leu
Thr Ser Asn Leu Asn Glu Val Arg 355 360 365 Thr Thr Cys Thr Asp Thr
Leu Thr Lys His Thr Asp Asp Leu Thr Ser 370 375 380 Leu Asn Asn Thr
Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 385 390 395 400 Met
Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 405 410
415 Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly
420 425 430 Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly
Pro Arg 435 440 445 Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro
Gly Pro Thr Gly 450 455 460 Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu
Pro Gly Pro Pro Gly Pro 465 470 475 480 Ala Gly Glu Arg Gly Pro Ile
Gly Pro Ala Gly Pro Pro Gly Glu Arg 485 490 495 Gly Gly Lys Gly Ser
Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 500 505 510 Ser Pro Gly
Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 515 520 525 Pro
Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 530 535
540 Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly
545 550 555 560 Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met
Pro Gly Pro 565 570 575 Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly
Ala Val Val Pro Leu 580 585 590 Ala Leu Gln Asn Glu Pro Thr Pro Ala
Pro Glu Asp Asn Gly Cys Pro 595 600 605 Pro His Trp Lys Asn Phe Thr
Asp Lys Cys Tyr Tyr Phe Ser Val Glu 610 615 620 Lys Glu Ile Phe Glu
Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 625 630 635 640 His Leu
Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 645 650 655
Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 660
665 670 Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr
Lys 675 680 685 Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly
His Gly Pro 690 695 700 Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly
Gln Trp Asn Asp Phe 705 710 715 720 Gln Cys Glu Asp Val Asn Asn Phe
Ile Cys Glu Lys Asp Arg Glu Thr 725 730 735 Val Leu Ser Ser Ala Leu
740
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