U.S. patent application number 14/507124 was filed with the patent office on 2015-01-22 for npp1 fusion proteins. The applicant listed for this patent is SYNAGEVA BIOPHARMA CORP.. Invention is credited to Alex J Harvey, Anthony Quinn, Zhinan Xia.
Application Number | 20150024460 14/507124 |
Document ID | / |
Family ID | 44564171 |
Filed Date | 2015-01-22 |
United States Patent Application | 20150024460 |
Kind Code | A1 |
Quinn; Anthony ; et al. | January 22, 2015 |
The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
Inventors: | Quinn; Anthony; (Gloucester, MA) ; Harvey; Alex J; (Athens, GA) ; Xia; Zhinan; (Wellesley, MA) | ||||||||||
Applicant: |
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Family ID: | 44564171 | ||||||||||
Appl. No.: | 14/507124 | ||||||||||
Filed: | October 6, 2014 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14004294 | Nov 14, 2013 | |||
PCT/US2011/051858 | Sep 15, 2011 | |||
14507124 | ||||
PCT/US2011/028233 | Mar 11, 2011 | |||
14004294 | ||||
Current U.S. Class: | 435/188 ; 435/320.1; 536/23.2 |
Current CPC Class: | C12N 15/8509 20130101; C12N 9/16 20130101; A61P 19/02 20180101; C12N 9/22 20130101; C12N 15/86 20130101; A61P 21/00 20180101; C12N 2840/007 20130101; A61P 9/00 20180101; C07K 2319/30 20130101; A61P 19/08 20180101; Y10S 530/827 20130101; A61P 7/00 20180101; A61K 38/00 20130101; C12N 15/625 20130101; C07K 2319/01 20130101; A61P 9/10 20180101; C07K 2319/00 20130101; A61P 3/10 20180101; C12N 9/96 20130101; C12Y 301/04001 20130101; C07K 2319/02 20130101; C07K 2319/33 20130101; C07K 7/06 20130101; C12N 9/00 20130101 |
Class at Publication: | 435/188 ; 536/23.2; 435/320.1 |
International Class: | C12N 9/16 20060101 C12N009/16 |
Sequence CWU 1
1
221925PRTHomo sapiens 1Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser
Arg Gly Gly Glu Gly 1 5 10 15 Gly Arg Ala Pro Arg Glu Gly Pro Ala
Gly Asn Gly Arg Asp Arg Gly 20 25 30 Arg Ser His Ala Ala Glu Ala
Pro Gly Asp Pro Gln Ala Ala Ala Ser 35 40 45 Leu Leu Ala Pro Met
Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 50 55 60 Arg Ala Arg
Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 65 70 75 80 Val
Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 85 90
95 Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys
100 105 110 Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys
Val Glu 115 120 125 Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys
Ile Glu Pro Glu 130 135 140 His Ile Trp Thr Cys Asn Lys Phe Arg Cys
Gly Glu Lys Arg Leu Thr 145 150 155 160 Arg Ser Leu Cys Ala Cys Ser
Asp Asp Cys Lys Asp Lys Gly Asp Cys 165 170 175 Cys Ile Asn Tyr Ser
Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 180 185 190 Glu Pro Cys
Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 195 200 205 Thr
Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 210 215
220 Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys
225 230 235 240 Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro
Thr Lys Thr 245 250 255 Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu
Tyr Pro Glu Ser His 260 265 270 Gly Ile Ile Asp Asn Lys Met Tyr Asp
Pro Lys Met Asn Ala Ser Phe 275 280 285 Ser Leu Lys Ser Lys Glu Lys
Phe Asn Pro Glu Trp Tyr Lys Gly Glu 290 295 300 Pro Ile Trp Val Thr
Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 305 310 315 320 Phe Trp
Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 325 330 335
Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 340
345 350 Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe
Tyr 355 360 365 Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser
Tyr Gly Pro 370 375 380 Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg
Val Asp Gly Met Val 385 390 395 400 Gly Met Leu Met Asp Gly Leu Lys
Glu Leu Asn Leu His Arg Cys Leu 405 410 415 Asn Leu Ile Leu Ile Ser
Asp His Gly Met Glu Gln Gly Ser Cys Lys 420 425 430 Lys Tyr Ile Tyr
Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 435 440 445 Val Ile
Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 450 455 460
Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 465
470 475 480 Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe
Leu Pro 485 490 495 Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu
Pro Leu Thr Phe 500 505 510 Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu
Asn Pro Ser Glu Arg Lys 515 520 525 Tyr Cys Gly Ser Gly Phe His Gly
Ser Asp Asn Val Phe Ser Asn Met 530 535 540 Gln Ala Leu Phe Val Gly
Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 545 550 555 560 Ala Asp Thr
Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 565 570 575 Leu
Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 580 585
590 His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val
595 600 605 His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp
Asn Leu 610 615 620 Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu
Asp Phe Gln Thr 625 630 635 640 Gln Phe Asn Leu Thr Val Ala Glu Glu
Lys Ile Ile Lys His Glu Thr 645 650 655 Leu Pro Tyr Gly Arg Pro Arg
Val Leu Gln Lys Glu Asn Thr Ile Cys 660 665 670 Leu Leu Ser Gln His
Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 675 680 685 Met Pro Leu
Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 690 695 700 Thr
Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 705 710
715 720 Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val
Ser 725 730 735 Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser
Ser Gly Ile 740 745 750 Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val
Pro Met Tyr Gln Ser 755 760 765 Phe Gln Val Ile Trp Arg Tyr Phe His
Asp Thr Leu Leu Arg Lys Tyr 770 775 780 Ala Glu Glu Arg Asn Gly Val
Asn Val Val Ser Gly Pro Val Phe Asp 785 790 795 800 Phe Asp Tyr Asp
Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 805 810 815 Arg Arg
Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 820 825 830
Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 835
840 845 Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp
Asn 850 855 860 Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp
Val Glu Glu 865 870 875 880 Leu Leu Met Leu His Arg Ala Arg Ile Thr
Asp Val Glu His Ile Thr 885 890 895 Gly Leu Ser Phe Tyr Gln Gln Arg
Lys Glu Pro Val Ser Asp Ile Leu 900 905 910 Lys Leu Lys Thr His Leu
Pro Thr Phe Ser Gln Glu Asp 915 920 925 2387PRTArtificial
sequenceSynthetic 2Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser
Leu Asp Gly Phe 1 5 10 15 Arg Ala Glu Tyr Leu His Thr Trp Gly Gly
Leu Leu Pro Val Ile Ser 20 25 30 Lys Leu Lys Lys Cys Gly Thr Tyr
Thr Lys Asn Met Arg Pro Val Tyr 35 40 45 Pro Thr Lys Thr Phe Pro
Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 50 55 60 Pro Glu Ser His
Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 65 70 75 80 Asn Ala
Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 85 90 95
Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 100
105 110 Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly
Ile 115 120 125 Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro
Phe Glu Glu 130 135 140 Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu
Pro Lys Asp Glu Arg 145 150 155 160 Pro His Phe Tyr Thr Leu Tyr Leu
Glu Glu Pro Asp Ser Ser Gly His 165 170 175 Ser Tyr Gly Pro Val Ser
Ser Glu Val Ile Lys Ala Leu Gln Arg Val 180 185 190 Asp Gly Met Val
Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 195 200 205 His Arg
Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 210 215 220
Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 225
230 235 240 Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg
Pro Ser 245 250 255 Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu
Gly Ile Ala Arg 260 265 270 Asn Leu Ser Cys Arg Glu Pro Asn Gln His
Phe Lys Pro Tyr Leu Lys 275 280 285 His Phe Leu Pro Lys Arg Leu His
Phe Ala Lys Ser Asp Arg Ile Glu 290 295 300 Pro Leu Thr Phe Tyr Leu
Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 305 310 315 320 Ser Glu Arg
Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 325 330 335 Phe
Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 340 345
350 His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu
355 360 365 Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly
Thr His 370 375 380 Gly Ser Leu 385 3420PRTArtificial
sequenceSynthetic 3Ile Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser
Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro Ser Met Ala Ser Met Asp
Asp Asp Asp Asp Asp Asp 20 25 30 Asp Ala Gly Phe Glu Thr Pro Pro
Thr Leu Leu Phe Ser Leu Asp Gly 35 40 45 Phe Arg Ala Glu Tyr Leu
His Thr Trp Gly Gly Leu Leu Pro Val Ile 50 55 60 Ser Lys Leu Lys
Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val 65 70 75 80 Tyr Pro
Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu 85 90 95
Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys 100
105 110 Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro
Glu 115 120 125 Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr
Gln Gly Leu 130 135 140 Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp
Val Glu Ile Asn Gly 145 150 155 160 Ile Phe Pro Asp Ile Tyr Lys Met
Tyr Asn Gly Ser Val Pro Phe Glu 165 170 175 Glu Arg Ile Leu Ala Val
Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu 180 185 190 Arg Pro His Phe
Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly 195 200 205 His Ser
Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg 210 215 220
Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn 225
230 235 240 Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly
Met Glu 245 250 255 Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys
Tyr Leu Gly Asp 260 265 270 Val Lys Asn Ile Lys Val Ile Tyr Gly Pro
Ala Ala Arg Leu Arg Pro 275 280 285 Ser Asp Val Pro Asp Lys Tyr Tyr
Ser Phe Asn Tyr Glu Gly Ile Ala 290 295 300 Arg Asn Leu Ser Cys Arg
Glu Pro Asn Gln His Phe Lys Pro Tyr Leu 305 310 315 320 Lys His Phe
Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile 325 330 335 Glu
Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn 340 345
350 Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn
355 360 365 Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro
Gly Phe 370 375 380 Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile
Glu Val Tyr Asn 385 390 395 400 Leu Met Cys Asp Leu Leu Asn Leu Thr
Pro Ala Pro Asn Asn Gly Thr 405 410 415 His Gly Ser Leu 420
4422PRTArtificial sequenceSynthetic 4Ile Gly Val Leu Leu Thr Gln
Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro Ser
Met Ala Ser Met Ala Gly Phe Glu Thr Pro Pro 20 25 30 Thr Leu Leu
Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr 35 40 45 Trp
Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr 50 55
60 Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn
65 70 75 80 His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly
Ile Ile 85 90 95 Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser
Phe Ser Leu Lys 100 105 110 Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr
Lys Gly Glu Pro Ile Trp 115 120 125 Val Thr Ala Lys Tyr Gln Gly Leu
Lys Ser Gly Thr Phe Phe Trp Pro 130 135 140 Gly Ser Asp Val Glu Ile
Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met 145 150 155 160 Tyr Asn Gly
Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln 165 170 175 Trp
Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr 180 185
190 Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser Ser
195 200 205 Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly
Met Leu 210 215 220 Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys
Leu Asn Leu Ile 225 230 235 240 Leu Ile Ser Asp His Gly Met Glu Gln
Gly Ser Cys Lys Lys Tyr Ile 245 250 255 Tyr Leu Asn Lys Tyr Leu Gly
Asp Val Lys Asn Ile Lys Val Ile Tyr 260 265 270 Gly Pro Ala Ala Arg
Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr 275 280 285 Ser Phe Asn
Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro 290 295 300 Asn
Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu 305 310
315 320 His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu
Asp 325 330 335 Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys
Tyr Cys Gly 340 345 350 Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser
Asn Met Gln Ala Leu 355 360 365 Phe Val Gly Tyr Gly Pro Gly Phe Lys
His Gly Ile Glu Ala Asp Thr 370 375 380 Phe Glu Asn Ile Glu Val Tyr
Asn Leu Met Cys Asp Leu Leu Asn Leu 385 390 395 400 Thr Pro Ala Pro
Asn Asn Gly Thr His Gly Ser Leu Asp Asp Asp Asp 405 410 415 Asp Asp
Asp Asp Asp Asp 420 52265DNAArtificial sequenceSynthetic
5atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca
60agcatggcga gcatggatga cgatgatgac gacgatgacg cagggtttga aacgcctcct
120acactcttgt tttctttgga tggattcagg gcagaatatt tgcacacttg
gggtggactt 180cttcctgtta ttagcaaact caaaaaatgt ggaacatata
ctaaaaacat gagaccggtg 240tatccaacaa aaactttccc caatcactac
agcattgtca ccggattgta tccagaatct 300catggcataa tcgacaataa
gatgtatgat cccaaaatga atgcttcctt ttcacttaaa 360agtaaagaga
aatttaatcc ggagtggtac aaaggagaac caatttgggt cacagctaag
420tatcaaggcc tcaagtctgg cacatttttc tggccaggat cagatgtgga
aattaacgga 480attttcccag acatctataa aatgtataat ggttcagtgc
catttgaaga aaggattttg 540gctgttcttc agtggctgca gcttccaaaa
gatgaaagac cacactttta cactttgtat 600ttggaagaac cagattcttc
aggtcattca tatggaccag tcagcagtga agtcatcaaa 660gccttgcaga
gggttgatgg tatggttggt atgctgatgg atggtctgaa agagctgaac
720ttgcacagat gcctgaacct catccttatt tcagatcatg gcatggaaca
aggcagttgt 780aagaaataca tatatctgaa taagtatttg ggggatgtta
aaaatattaa agttatctat
840ggacctgcag ctcgattgag accctctgat gtcccagata aatactattc
atttaactat 900gaaggcattg cccgaaatct ttcttgccgg gaaccaaacc
agcacttcaa accttatctg 960aaacatttct tgcctaagcg tttgcacttt
gctaagagtg atagaattga gcccttgaca 1020ttctatttgg accctcagtg
gcaacttgca ttgaatccct cagaaaggaa atattgtgga 1080agtggatttc
atggctctga caatgtgttt tcaaatatgc aagccctctt tgttggctat
1140ggacctggat tcaagcatgg cattgaggct gacacctttg aaaacattga
agtctataac 1200ttgatgtgtg atttgctgaa tttgacaccg gctcctaata
acggaactca tggaagtctt 1260aaccaccttc tgaagaatcc tgtttatacg
ccaaagcatc ccaaagaagt gcaccccctg 1320gtgcagtgcc ccttcacaag
aaaccccaga gataaccttg gctgctcatg taacccttcc 1380attttgccga
ttgaggattt tcaaacacag ttcaatctga ccgtggcaga agagaagatt
1440attaagcatg aaactttgcc ctatggaaga cctagagttc tccagaagga
aaacaccatc 1500tgtcttcttt cccagcacca gtttatgagt ggatacagcc
aagacatctt gatgcccctt 1560tggacatcct ataccgtgga cagaaatgac
agtttctcta cggaagactt ctccaactgt 1620ctgtaccagg actttagaat
tcctcttagt cctgtccata aatgttcatt ttataaaaat 1680aacaccaaag
tgagttacgg gttcctctcc ccaccacaac tgaataagaa ttcaagtgga
1740atatattctg aagccttgct tactacaaat atagtgccaa tgtaccagag
ttttcaagtt 1800atatggcgct actttcatga caccctcttg cgaaagtatg
cagaagaaag aaatggtgtc 1860aatgtcgtca gtggtcctgt gtttgacttt
gattatgatg gacgttgtga ttccttggag 1920aatttgaggc aaaaaagaag
agtcatccgt aaccaagaaa ttttgattcc aactcatttc 1980ttcattgtgc
tgacaagctg taaagataca tctcagacgc ctttgcactg tgaaaacctg
2040gacaccttgg ctttcatttt gcctcacagg actgataaca gcgagagctg
tgtgcatggg 2100aagcatgact cctcatgggt tgaagaattg ttgatgttgc
acagagcacg gatcacagac 2160gtcgagcaca tcactggact cagcttttat
caacaaagaa aagagccagt ttcagacatt 2220ttgaagttga aaacacattt
gccaaccttt agccaagaag attga 22656754PRTArtificial SequenceSynthetic
6Ile Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1
5 10 15 Leu Leu Phe Pro Ser Met Ala Ser Met Asp Asp Asp Asp Asp Asp
Asp 20 25 30 Asp Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser
Leu Asp Gly 35 40 45 Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly
Leu Leu Pro Val Ile 50 55 60 Ser Lys Leu Lys Lys Cys Gly Thr Tyr
Thr Lys Asn Met Arg Pro Val 65 70 75 80 Tyr Pro Thr Lys Thr Phe Pro
Asn His Tyr Ser Ile Val Thr Gly Leu 85 90 95 Tyr Pro Glu Ser His
Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys 100 105 110 Met Asn Ala
Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu 115 120 125 Trp
Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu 130 135
140 Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly
145 150 155 160 Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val
Pro Phe Glu 165 170 175 Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln
Leu Pro Lys Asp Glu 180 185 190 Arg Pro His Phe Tyr Thr Leu Tyr Leu
Glu Glu Pro Asp Ser Ser Gly 195 200 205 His Ser Tyr Gly Pro Val Ser
Ser Glu Val Ile Lys Ala Leu Gln Arg 210 215 220 Val Asp Gly Met Val
Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn 225 230 235 240 Leu His
Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu 245 250 255
Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp 260
265 270 Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg
Pro 275 280 285 Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu
Gly Ile Ala 290 295 300 Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His
Phe Lys Pro Tyr Leu 305 310 315 320 Lys His Phe Leu Pro Lys Arg Leu
His Phe Ala Lys Ser Asp Arg Ile 325 330 335 Glu Pro Leu Thr Phe Tyr
Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn 340 345 350 Pro Ser Glu Arg
Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn 355 360 365 Val Phe
Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe 370 375 380
Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn 385
390 395 400 Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn
Gly Thr 405 410 415 His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val
Tyr Thr Pro Lys 420 425 430 His Pro Lys Glu Val His Pro Leu Val Gln
Cys Pro Phe Thr Arg Asn 435 440 445 Pro Arg Asp Asn Leu Gly Cys Ser
Cys Asn Pro Ser Ile Leu Pro Ile 450 455 460 Glu Asp Phe Gln Thr Gln
Phe Asn Leu Thr Val Ala Glu Glu Lys Ile 465 470 475 480 Ile Lys His
Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys 485 490 495 Glu
Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr 500 505
510 Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg
515 520 525 Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr
Gln Asp 530 535 540 Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser
Phe Tyr Lys Asn 545 550 555 560 Asn Thr Lys Val Ser Tyr Gly Phe Leu
Ser Pro Pro Gln Leu Asn Lys 565 570 575 Asn Ser Ser Gly Ile Tyr Ser
Glu Ala Leu Leu Thr Thr Asn Ile Val 580 585 590 Pro Met Tyr Gln Ser
Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr 595 600 605 Leu Leu Arg
Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser 610 615 620 Gly
Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu 625 630
635 640 Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu
Ile 645 650 655 Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp
Thr Ser Gln 660 665 670 Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu
Ala Phe Ile Leu Pro 675 680 685 His Arg Thr Asp Asn Ser Glu Ser Cys
Val His Gly Lys His Asp Ser 690 695 700 Ser Trp Val Glu Glu Leu Leu
Met Leu His Arg Ala Arg Ile Thr Asp 705 710 715 720 Val Glu His Ile
Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro 725 730 735 Val Ser
Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln 740 745 750
Glu Asp 72238DNAArtificial SequenceSynthetic 7atgggtgtac tgctcacaca
gaggacgctg ctcagtctgg tccttgcact cctgtttcca 60agcatggcga gcatggcagg
gtttgaaacg cctcctacac tcttgttttc tttggatgga 120ttcagggcag
aatatttgca cacttggggt ggacttcttc ctgttattag caaactcaaa
180aaatgtggaa catatactaa aaacatgaga ccggtgtatc caacaaaaac
tttccccaat 240cactacagca ttgtcaccgg attgtatcca gaatctcatg
gcataatcga caataagatg 300tatgatccca aaatgaatgc ttccttttca
cttaaaagta aagagaaatt taatccggag 360tggtacaaag gagaaccaat
ttgggtcaca gctaagtatc aaggcctcaa gtctggcaca 420tttttctggc
caggatcaga tgtggaaatt aacggaattt tcccagacat ctataaaatg
480tataatggtt cagtgccatt tgaagaaagg attttggctg ttcttcagtg
gctgcagctt 540ccaaaagatg aaagaccaca cttttacact ttgtatttgg
aagaaccaga ttcttcaggt 600cattcatatg gaccagtcag cagtgaagtc
atcaaagcct tgcagagggt tgatggtatg 660gttggtatgc tgatggatgg
tctgaaagag ctgaacttgc acagatgcct gaacctcatc 720cttatttcag
atcatggcat ggaacaaggc agttgtaaga aatacatata tctgaataag
780tatttggggg atgttaaaaa tattaaagtt atctatggac ctgcagctcg
attgagaccc 840tctgatgtcc cagataaata ctattcattt aactatgaag
gcattgcccg aaatctttct 900tgccgggaac caaaccagca cttcaaacct
tatctgaaac atttcttgcc taagcgtttg 960cactttgcta agagtgatag
aattgagccc ttgacattct atttggaccc tcagtggcaa 1020cttgcattga
atccctcaga aaggaaatat tgtggaagtg gatttcatgg ctctgacaat
1080gtgttttcaa atatgcaagc cctctttgtt ggctatggac ctggattcaa
gcatggcatt 1140gaggctgaca cctttgaaaa cattgaagtc tataacttga
tgtgtgattt gctgaatttg 1200acaccggctc ctaataacgg aactcatgga
agtcttaacc accttctgaa gaatcctgtt 1260tatacgccaa agcatcccaa
agaagtgcac cccctggtgc agtgcccctt cacaagaaac 1320cccagagata
accttggctg ctcatgtaac ccttccattt tgccgattga ggattttcaa
1380acacagttca atctgaccgt ggcagaagag aagattatta agcatgaaac
tttgccctat 1440ggaagaccta gagttctcca gaaggaaaac accatctgtc
ttctttccca gcaccagttt 1500atgagtggat acagccaaga catcttgatg
cccctttgga catcctatac cgtggacaga 1560aatgacagtt tctctacgga
agacttctcc aactgtctgt accaggactt tagaattcct 1620cttagtcctg
tccataaatg ttcattttat aaaaataaca ccaaagtgag ttacgggttc
1680ctctccccac cacaactgaa taagaattca agtggaatat attctgaagc
cttgcttact 1740acaaatatag tgccaatgta ccagagtttt caagttatat
ggcgctactt tcatgacacc 1800ctcttgcgaa agtatgcaga agaaagaaat
ggtgtcaatg tcgtcagtgg tcctgtgttt 1860gactttgatt atgatggacg
ttgtgattcc ttggagaatt tgaggcaaaa aagaagagtc 1920atccgtaacc
aagaaatttt gattccaact catttcttca ttgtgctgac aagctgtaaa
1980gatacatctc agacgccttt gcactgtgaa aacctggaca ccttggcttt
cattttgcct 2040cacaggactg ataacagcga gagctgtgtg catgggaagc
atgactcctc atgggttgaa 2100gaattgttga tgttgcacag agcacggatc
acagacgtcg agcacatcac tggactcagc 2160ttttatcaac aaagaaaaga
gccagtttca gacattttga agttgaaaac acatttgcca 2220acctttagcc aagaagat
22388746PRTArtificial sequenceSynthetic 8Ile Gly Val Leu Leu Thr
Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro
Ser Met Ala Ser Met Ala Gly Phe Glu Thr Pro Pro 20 25 30 Thr Leu
Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr 35 40 45
Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr 50
55 60 Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro
Asn 65 70 75 80 His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His
Gly Ile Ile 85 90 95 Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala
Ser Phe Ser Leu Lys 100 105 110 Ser Lys Glu Lys Phe Asn Pro Glu Trp
Tyr Lys Gly Glu Pro Ile Trp 115 120 125 Val Thr Ala Lys Tyr Gln Gly
Leu Lys Ser Gly Thr Phe Phe Trp Pro 130 135 140 Gly Ser Asp Val Glu
Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met 145 150 155 160 Tyr Asn
Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln 165 170 175
Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr 180
185 190 Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser
Ser 195 200 205 Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val
Gly Met Leu 210 215 220 Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg
Cys Leu Asn Leu Ile 225 230 235 240 Leu Ile Ser Asp His Gly Met Glu
Gln Gly Ser Cys Lys Lys Tyr Ile 245 250 255 Tyr Leu Asn Lys Tyr Leu
Gly Asp Val Lys Asn Ile Lys Val Ile Tyr 260 265 270 Gly Pro Ala Ala
Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr 275 280 285 Ser Phe
Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro 290 295 300
Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu 305
310 315 320 His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr
Leu Asp 325 330 335 Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg
Lys Tyr Cys Gly 340 345 350 Ser Gly Phe His Gly Ser Asp Asn Val Phe
Ser Asn Met Gln Ala Leu 355 360 365 Phe Val Gly Tyr Gly Pro Gly Phe
Lys His Gly Ile Glu Ala Asp Thr 370 375 380 Phe Glu Asn Ile Glu Val
Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu 385 390 395 400 Thr Pro Ala
Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu 405 410 415 Lys
Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro Leu 420 425
430 Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser
435 440 445 Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln
Phe Asn 450 455 460 Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu
Thr Leu Pro Tyr 465 470 475 480 Gly Arg Pro Arg Val Leu Gln Lys Glu
Asn Thr Ile Cys Leu Leu Ser 485 490 495 Gln His Gln Phe Met Ser Gly
Tyr Ser Gln Asp Ile Leu Met Pro Leu 500 505 510 Trp Thr Ser Tyr Thr
Val Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp 515 520 525 Phe Ser Asn
Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro Val 530 535 540 His
Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe 545 550
555 560 Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser
Glu 565 570 575 Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser
Phe Gln Val 580 585 590 Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg
Lys Tyr Ala Glu Glu 595 600 605 Arg Asn Gly Val Asn Val Val Ser Gly
Pro Val Phe Asp Phe Asp Tyr 610 615 620 Asp Gly Arg Cys Asp Ser Leu
Glu Asn Leu Arg Gln Lys Arg Arg Val 625 630 635 640 Ile Arg Asn Gln
Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu 645 650 655 Thr Ser
Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn Leu 660 665 670
Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu Ser 675
680 685 Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu
Met 690 695 700 Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr
Gly Leu Ser 705 710 715 720 Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser
Asp Ile Leu Lys Leu Lys 725 730 735 Thr His Leu Pro Thr Phe Ser Gln
Glu Asp 740 745 92556DNAArtificial sequenceSynthetic 9atgggtgtac
tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca 60agcatggcga
gcatgccaag ttgtgccaaa gaagttaaaa gttgcaaagg tcgctgtttc
120gagagaacat ttgggaactg tcgctgtgat gctgcctgtg ttgagcttgg
aaactgctgt 180ttggattacc aggagacgtg catagaacca gaacatatat
ggacttgcaa caaattcagg 240tgtggtgaga aaagattgac cagaagcctc
tgtgcctgtt cagatgattg caaggacaag 300ggcgactgct gcatcaacta
cagttcagtg tgtcaaggtg agaaaagttg ggtggaagaa 360ccatgtgaga
gcattaatga gccacagtgc ccagcagggt ttgaaacgcc tcctacactc
420ttgttttctt tggatggatt cagggcagaa tatttgcaca cttggggtgg
acttcttcct 480gttattagca aactcaaaaa atgtggaaca tatactaaaa
acatgagacc ggtgtatcca 540acaaaaactt tccccaatca ctacagcatt
gtcaccggat tgtatccaga atctcatggc 600ataatcgaca ataagatgta
tgatcccaaa atgaatgctt ccttttcact taaaagtaaa 660gagaaattta
atccggagtg gtacaaagga gaaccaattt gggtcacagc taagtatcaa
720ggcctcaagt ctggcacatt tttctggcca ggatcagatg tggaaattaa
cggaattttc 780ccagacatct ataaaatgta taatggttca gtgccatttg
aagaaaggat tttggctgtt 840cttcagtggc tgcagcttcc aaaagatgaa
agaccacact tttacacttt gtatttggaa 900gaaccagatt cttcaggtca
ttcatatgga ccagtcagca gtgaagtcat caaagccttg 960cagagggttg
atggtatggt tggtatgctg atggatggtc tgaaagagct gaacttgcac
1020agatgcctga acctcatcct tatttcagat catggcatgg aacaaggcag
ttgtaagaaa 1080tacatatatc tgaataagta tttgggggat gttaaaaata
ttaaagttat ctatggacct 1140gcagctcgat tgagaccctc tgatgtccca
gataaatact attcatttaa ctatgaaggc 1200attgcccgaa atctttcttg
ccgggaacca aaccagcact tcaaacctta tctgaaacat 1260ttcttgccta
agcgtttgca ctttgctaag agtgatagaa ttgagccctt gacattctat
1320ttggaccctc agtggcaact tgcattgaat ccctcagaaa ggaaatattg
tggaagtgga 1380tttcatggct ctgacaatgt gttttcaaat atgcaagccc
tctttgttgg
ctatggacct 1440ggattcaagc atggcattga ggctgacacc tttgaaaaca
ttgaagtcta taacttgatg 1500tgtgatttgc tgaatttgac accggctcct
aataacggaa ctcatggaag tcttaaccac 1560cttctgaaga atcctgttta
tacgccaaag catcccaaag aagtgcaccc cctggtgcag 1620tgccccttca
caagaaaccc cagagataac cttggctgct catgtaaccc ttccattttg
1680ccgattgagg attttcaaac acagttcaat ctgaccgtgg cagaagagaa
gattattaag 1740catgaaactt tgccctatgg aagacctaga gttctccaga
aggaaaacac catctgtctt 1800ctttcccagc accagtttat gagtggatac
agccaagaca tcttgatgcc cctttggaca 1860tcctataccg tggacagaaa
tgacagtttc tctacggaag acttctccaa ctgtctgtac 1920caggacttta
gaattcctct tagtcctgtc cataaatgtt cattttataa aaataacacc
1980aaagtgagtt acgggttcct ctccccacca caactgaata agaattcaag
tggaatatat 2040tctgaagcct tgcttactac aaatatagtg ccaatgtacc
agagttttca agttatatgg 2100cgctactttc atgacaccct cttgcgaaag
tatgcagaag aaagaaatgg tgtcaatgtc 2160gtcagtggtc ctgtgtttga
ctttgattat gatggacgtt gtgattcctt ggagaatttg 2220aggcaaaaaa
gaagagtcat ccgtaaccaa gaaattttga ttccaactca tttcttcatt
2280gtgctgacaa gctgtaaaga tacatctcag acgcctttgc actgtgaaaa
cctggacacc 2340ttggctttca ttttgcctca caggactgat aacagcgaga
gctgtgtgca tgggaagcat 2400gactcctcat gggttgaaga attgttgatg
ttgcacagag cacggatcac agacgtcgag 2460cacatcactg gactcagctt
ttatcaacaa agaaaagagc cagtttcaga cattttgaag 2520ttgaaaacac
atttgccaac ctttagccaa gaagat 255610852PRTArtificial
seqeunceSynthetic 10Ile Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser
Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro Ser Met Ala Ser Met Pro
Ser Cys Ala Lys Glu Val 20 25 30 Lys Ser Cys Lys Gly Arg Cys Phe
Glu Arg Thr Phe Gly Asn Cys Arg 35 40 45 Cys Asp Ala Ala Cys Val
Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln 50 55 60 Glu Thr Cys Ile
Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg 65 70 75 80 Cys Gly
Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp 85 90 95
Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln 100
105 110 Gly Glu Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu
Pro 115 120 125 Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu
Phe Ser Leu 130 135 140 Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp
Gly Gly Leu Leu Pro 145 150 155 160 Val Ile Ser Lys Leu Lys Lys Cys
Gly Thr Tyr Thr Lys Asn Met Arg 165 170 175 Pro Val Tyr Pro Thr Lys
Thr Phe Pro Asn His Tyr Ser Ile Val Thr 180 185 190 Gly Leu Tyr Pro
Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp 195 200 205 Pro Lys
Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn 210 215 220
Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln 225
230 235 240 Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val
Glu Ile 245 250 255 Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn
Gly Ser Val Pro 260 265 270 Phe Glu Glu Arg Ile Leu Ala Val Leu Gln
Trp Leu Gln Leu Pro Lys 275 280 285 Asp Glu Arg Pro His Phe Tyr Thr
Leu Tyr Leu Glu Glu Pro Asp Ser 290 295 300 Ser Gly His Ser Tyr Gly
Pro Val Ser Ser Glu Val Ile Lys Ala Leu 305 310 315 320 Gln Arg Val
Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu 325 330 335 Leu
Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly 340 345
350 Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu
355 360 365 Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala
Arg Leu 370 375 380 Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe
Asn Tyr Glu Gly 385 390 395 400 Ile Ala Arg Asn Leu Ser Cys Arg Glu
Pro Asn Gln His Phe Lys Pro 405 410 415 Tyr Leu Lys His Phe Leu Pro
Lys Arg Leu His Phe Ala Lys Ser Asp 420 425 430 Arg Ile Glu Pro Leu
Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala 435 440 445 Leu Asn Pro
Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser 450 455 460 Asp
Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro 465 470
475 480 Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu
Val 485 490 495 Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala
Pro Asn Asn 500 505 510 Gly Thr His Gly Ser Leu Asn His Leu Leu Lys
Asn Pro Val Tyr Thr 515 520 525 Pro Lys His Pro Lys Glu Val His Pro
Leu Val Gln Cys Pro Phe Thr 530 535 540 Arg Asn Pro Arg Asp Asn Leu
Gly Cys Ser Cys Asn Pro Ser Ile Leu 545 550 555 560 Pro Ile Glu Asp
Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu 565 570 575 Lys Ile
Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu 580 585 590
Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser 595
600 605 Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr
Val 610 615 620 Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn
Cys Leu Tyr 625 630 635 640 Gln Asp Phe Arg Ile Pro Leu Ser Pro Val
His Lys Cys Ser Phe Tyr 645 650 655 Lys Asn Asn Thr Lys Val Ser Tyr
Gly Phe Leu Ser Pro Pro Gln Leu 660 665 670 Asn Lys Asn Ser Ser Gly
Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn 675 680 685 Ile Val Pro Met
Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His 690 695 700 Asp Thr
Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val 705 710 715
720 Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser
725 730 735 Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln
Glu Ile 740 745 750 Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser
Cys Lys Asp Thr 755 760 765 Ser Gln Thr Pro Leu His Cys Glu Asn Leu
Asp Thr Leu Ala Phe Ile 770 775 780 Leu Pro His Arg Thr Asp Asn Ser
Glu Ser Cys Val His Gly Lys His 785 790 795 800 Asp Ser Ser Trp Val
Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile 805 810 815 Thr Asp Val
Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys 820 825 830 Glu
Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe 835 840
845 Ser Gln Glu Asp 850 112580DNAArtificial sequenceSynthetic
11atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca
60agcatggcga gcatggatga cgatgatgac gacgatgacc caagttgtgc caaagaagtt
120aaaagttgca aaggtcgctg tttcgagaga acatttggga actgtcgctg
tgatgctgcc 180tgtgttgagc ttggaaactg ctgtttggat taccaggaga
cgtgcataga accagaacat 240atatggactt gcaacaaatt caggtgtggt
gagaaaagat tgaccagaag cctctgtgcc 300tgttcagatg attgcaagga
caagggcgac tgctgcatca actacagttc agtgtgtcaa 360ggtgagaaaa
gttgggtgga agaaccatgt gagagcatta atgagccaca gtgcccagca
420gggtttgaaa cgcctcctac actcttgttt tctttggatg gattcagggc
agaatatttg 480cacacttggg gtggacttct tcctgttatt agcaaactca
aaaaatgtgg aacatatact 540aaaaacatga gaccggtgta tccaacaaaa
actttcccca atcactacag cattgtcacc 600ggattgtatc cagaatctca
tggcataatc gacaataaga tgtatgatcc caaaatgaat 660gcttcctttt
cacttaaaag taaagagaaa tttaatccgg agtggtacaa aggagaacca
720atttgggtca cagctaagta tcaaggcctc aagtctggca catttttctg
gccaggatca 780gatgtggaaa ttaacggaat tttcccagac atctataaaa
tgtataatgg ttcagtgcca 840tttgaagaaa ggattttggc tgttcttcag
tggctgcagc ttccaaaaga tgaaagacca 900cacttttaca ctttgtattt
ggaagaacca gattcttcag gtcattcata tggaccagtc 960agcagtgaag
tcatcaaagc cttgcagagg gttgatggta tggttggtat gctgatggat
1020ggtctgaaag agctgaactt gcacagatgc ctgaacctca tccttatttc
agatcatggc 1080atggaacaag gcagttgtaa gaaatacata tatctgaata
agtatttggg ggatgttaaa 1140aatattaaag ttatctatgg acctgcagct
cgattgagac cctctgatgt cccagataaa 1200tactattcat ttaactatga
aggcattgcc cgaaatcttt cttgccggga accaaaccag 1260cacttcaaac
cttatctgaa acatttcttg cctaagcgtt tgcactttgc taagagtgat
1320agaattgagc ccttgacatt ctatttggac cctcagtggc aacttgcatt
gaatccctca 1380gaaaggaaat attgtggaag tggatttcat ggctctgaca
atgtgttttc aaatatgcaa 1440gccctctttg ttggctatgg acctggattc
aagcatggca ttgaggctga cacctttgaa 1500aacattgaag tctataactt
gatgtgtgat ttgctgaatt tgacaccggc tcctaataac 1560ggaactcatg
gaagtcttaa ccaccttctg aagaatcctg tttatacgcc aaagcatccc
1620aaagaagtgc accccctggt gcagtgcccc ttcacaagaa accccagaga
taaccttggc 1680tgctcatgta acccttccat tttgccgatt gaggattttc
aaacacagtt caatctgacc 1740gtggcagaag agaagattat taagcatgaa
actttgccct atggaagacc tagagttctc 1800cagaaggaaa acaccatctg
tcttctttcc cagcaccagt ttatgagtgg atacagccaa 1860gacatcttga
tgcccctttg gacatcctat accgtggaca gaaatgacag tttctctacg
1920gaagacttct ccaactgtct gtaccaggac tttagaattc ctcttagtcc
tgtccataaa 1980tgttcatttt ataaaaataa caccaaagtg agttacgggt
tcctctcccc accacaactg 2040aataagaatt caagtggaat atattctgaa
gccttgctta ctacaaatat agtgccaatg 2100taccagagtt ttcaagttat
atggcgctac tttcatgaca ccctcttgcg aaagtatgca 2160gaagaaagaa
atggtgtcaa tgtcgtcagt ggtcctgtgt ttgactttga ttatgatgga
2220cgttgtgatt ccttggagaa tttgaggcaa aaaagaagag tcatccgtaa
ccaagaaatt 2280ttgattccaa ctcatttctt cattgtgctg acaagctgta
aagatacatc tcagacgcct 2340ttgcactgtg aaaacctgga caccttggct
ttcattttgc ctcacaggac tgataacagc 2400gagagctgtg tgcatgggaa
gcatgactcc tcatgggttg aagaattgtt gatgttgcac 2460agagcacgga
tcacagacgt cgagcacatc actggactca gcttttatca acaaagaaaa
2520gagccagttt cagacatttt gaagttgaaa acacatttgc caacctttag
ccaagaagat 258012860PRTArtificial sequenceSynthetic 12Ile Gly Val
Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu
Leu Phe Pro Ser Met Ala Ser Met Asp Asp Asp Asp Asp Asp Asp 20 25
30 Asp Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe
35 40 45 Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val
Glu Leu 50 55 60 Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile
Glu Pro Glu His 65 70 75 80 Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly
Glu Lys Arg Leu Thr Arg 85 90 95 Ser Leu Cys Ala Cys Ser Asp Asp
Cys Lys Asp Lys Gly Asp Cys Cys 100 105 110 Ile Asn Tyr Ser Ser Val
Cys Gln Gly Glu Lys Ser Trp Val Glu Glu 115 120 125 Pro Cys Glu Ser
Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr 130 135 140 Pro Pro
Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu 145 150 155
160 His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys
165 170 175 Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys
Thr Phe 180 185 190 Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro
Glu Ser His Gly 195 200 205 Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys
Met Asn Ala Ser Phe Ser 210 215 220 Leu Lys Ser Lys Glu Lys Phe Asn
Pro Glu Trp Tyr Lys Gly Glu Pro 225 230 235 240 Ile Trp Val Thr Ala
Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe 245 250 255 Trp Pro Gly
Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr 260 265 270 Lys
Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val 275 280
285 Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr
290 295 300 Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly
Pro Val 305 310 315 320 Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val
Asp Gly Met Val Gly 325 330 335 Met Leu Met Asp Gly Leu Lys Glu Leu
Asn Leu His Arg Cys Leu Asn 340 345 350 Leu Ile Leu Ile Ser Asp His
Gly Met Glu Gln Gly Ser Cys Lys Lys 355 360 365 Tyr Ile Tyr Leu Asn
Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val 370 375 380 Ile Tyr Gly
Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys 385 390 395 400
Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg 405
410 415 Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro
Lys 420 425 430 Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu
Thr Phe Tyr 435 440 445 Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro
Ser Glu Arg Lys Tyr 450 455 460 Cys Gly Ser Gly Phe His Gly Ser Asp
Asn Val Phe Ser Asn Met Gln 465 470 475 480 Ala Leu Phe Val Gly Tyr
Gly Pro Gly Phe Lys His Gly Ile Glu Ala 485 490 495 Asp Thr Phe Glu
Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu 500 505 510 Asn Leu
Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His 515 520 525
Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His 530
535 540 Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu
Gly 545 550 555 560 Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp
Phe Gln Thr Gln 565 570 575 Phe Asn Leu Thr Val Ala Glu Glu Lys Ile
Ile Lys His Glu Thr Leu 580 585 590 Pro Tyr Gly Arg Pro Arg Val Leu
Gln Lys Glu Asn Thr Ile Cys Leu 595 600 605 Leu Ser Gln His Gln Phe
Met Ser Gly Tyr Ser Gln Asp Ile Leu Met 610 615 620 Pro Leu Trp Thr
Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr 625 630 635 640 Glu
Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser 645 650
655 Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr
660 665 670 Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly
Ile Tyr 675 680 685 Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met
Tyr Gln Ser Phe 690 695 700 Gln Val Ile Trp Arg Tyr Phe His Asp Thr
Leu Leu Arg Lys Tyr Ala 705 710 715 720 Glu Glu Arg Asn Gly Val Asn
Val Val Ser Gly Pro Val Phe Asp Phe 725 730 735 Asp Tyr Asp Gly Arg
Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg 740 745 750 Arg Val Ile
Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile 755 760 765 Val
Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu 770 775
780 Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser
785 790 795 800 Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val
Glu Glu Leu 805 810 815 Leu Met Leu His Arg Ala Arg Ile Thr Asp Val
Glu His Ile Thr Gly 820 825 830 Leu Ser Phe Tyr Gln Gln Arg Lys Glu
Pro Val Ser Asp Ile Leu Lys 835 840 845 Leu Lys Thr His Leu Pro Thr
Phe Ser Gln Glu Asp 850 855 860 132580DNAArtificial
sequenceSynthetic 13gtgggtgtac
tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca 60agcatggcga
gcatgccaag ttgtgccaaa gaagttaaaa gttgcaaagg tcgctgtttc
120gagagaacat ttgggaactg tcgctgtgat gctgcctgtg ttgagcttgg
aaactgctgt 180ttggattacc aggagacgtg catagaacca gaacatatat
ggacttgcaa caaattcagg 240tgtggtgaga aaagattgac cagaagcctc
tgtgcctgtt cagatgattg caaggacaag 300ggcgactgct gcatcaacta
cagttcagtg tgtcaaggtg agaaaagttg ggtggaagaa 360ccatgtgaga
gcattaatga gccacagtgc ccagcagggt ttgaaacgcc tcctacactc
420ttgttttctt tggatggatt cagggcagaa tatttgcaca cttggggtgg
acttcttcct 480gttattagca aactcaaaaa atgtggaaca tatactaaaa
acatgagacc ggtgtatcca 540acaaaaactt tccccaatca ctacagcatt
gtcaccggat tgtatccaga atctcatggc 600ataatcgaca ataagatgta
tgatcccaaa atgaatgctt ccttttcact taaaagtaaa 660gagaaattta
atccggagtg gtacaaagga gaaccaattt gggtcacagc taagtatcaa
720ggcctcaagt ctggcacatt tttctggcca ggatcagatg tggaaattaa
cggaattttc 780ccagacatct ataaaatgta taatggttca gtgccatttg
aagaaaggat tttggctgtt 840cttcagtggc tgcagcttcc aaaagatgaa
agaccacact tttacacttt gtatttggaa 900gaaccagatt cttcaggtca
ttcatatgga ccagtcagca gtgaagtcat caaagccttg 960cagagggttg
atggtatggt tggtatgctg atggatggtc tgaaagagct gaacttgcac
1020agatgcctga acctcatcct tatttcagat catggcatgg aacaaggcag
ttgtaagaaa 1080tacatatatc tgaataagta tttgggggat gttaaaaata
ttaaagttat ctatggacct 1140gcagctcgat tgagaccctc tgatgtccca
gataaatact attcatttaa ctatgaaggc 1200attgcccgaa atctttcttg
ccgggaacca aaccagcact tcaaacctta tctgaaacat 1260ttcttgccta
agcgtttgca ctttgctaag agtgatagaa ttgagccctt gacattctat
1320ttggaccctc agtggcaact tgcattgaat ccctcagaaa ggaaatattg
tggaagtgga 1380tttcatggct ctgacaatgt gttttcaaat atgcaagccc
tctttgttgg ctatggacct 1440ggattcaagc atggcattga ggctgacacc
tttgaaaaca ttgaagtcta taacttgatg 1500tgtgatttgc tgaatttgac
accggctcct aataacggaa ctcatggaag tcttaaccac 1560cttctgaaga
atcctgttta tacgccaaag catcccaaag aagtgcaccc cctggtgcag
1620tgccccttca caagaaaccc cagagataac cttggctgct catgtaaccc
ttccattttg 1680ccgattgagg attttcaaac acagttcaat ctgaccgtgg
cagaagagaa gattattaag 1740catgaaactt tgccctatgg aagacctaga
gttctccaga aggaaaacac catctgtctt 1800ctttcccagc accagtttat
gagtggatac agccaagaca tcttgatgcc cctttggaca 1860tcctataccg
tggacagaaa tgacagtttc tctacggaag acttctccaa ctgtctgtac
1920caggacttta gaattcctct tagtcctgtc cataaatgtt cattttataa
aaataacacc 1980aaagtgagtt acgggttcct ctccccacca caactgaata
agaattcaag tggaatatat 2040tctgaagcct tgcttactac aaatatagtg
ccaatgtacc agagttttca agttatatgg 2100cgctactttc atgacaccct
cttgcgaaag tatgcagaag aaagaaatgg tgtcaatgtc 2160gtcagtggtc
ctgtgtttga ctttgattat gatggacgtt gtgattcctt ggagaatttg
2220aggcaaaaaa gaagagtcat ccgtaaccaa gaaattttga ttccaactca
tttcttcatt 2280gtgctgacaa gctgtaaaga tacatctcag acgcctttgc
actgtgaaaa cctggacacc 2340ttggctttca ttttgcctca caggactgat
aacagcgaga gctgtgtgca tgggaagcat 2400gactcctcat gggttgaaga
attgttgatg ttgcacagag cacggatcac agacgtcgag 2460cacatcactg
gactcagctt ttatcaacaa agaaaagagc cagtttcaga cattttgaag
2520ttgaaaacac atttgccaac ctttagccaa gaagatgatg acgatgatga
cgacgattga 258014859PRTArtificial sequenceSynthetic 14Gln Gly Val
Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu
Leu Phe Pro Ser Met Ala Ser Met Pro Ser Cys Ala Lys Glu Val 20 25
30 Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg
35 40 45 Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp
Tyr Gln 50 55 60 Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys
Asn Lys Phe Arg 65 70 75 80 Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu
Cys Ala Cys Ser Asp Asp 85 90 95 Cys Lys Asp Lys Gly Asp Cys Cys
Ile Asn Tyr Ser Ser Val Cys Gln 100 105 110 Gly Glu Lys Ser Trp Val
Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro 115 120 125 Gln Cys Pro Ala
Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu 130 135 140 Asp Gly
Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 145 150 155
160 Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg
165 170 175 Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile
Val Thr 180 185 190 Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn
Lys Met Tyr Asp 195 200 205 Pro Lys Met Asn Ala Ser Phe Ser Leu Lys
Ser Lys Glu Lys Phe Asn 210 215 220 Pro Glu Trp Tyr Lys Gly Glu Pro
Ile Trp Val Thr Ala Lys Tyr Gln 225 230 235 240 Gly Leu Lys Ser Gly
Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile 245 250 255 Asn Gly Ile
Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 260 265 270 Phe
Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 275 280
285 Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser
290 295 300 Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys
Ala Leu 305 310 315 320 Gln Arg Val Asp Gly Met Val Gly Met Leu Met
Asp Gly Leu Lys Glu 325 330 335 Leu Asn Leu His Arg Cys Leu Asn Leu
Ile Leu Ile Ser Asp His Gly 340 345 350 Met Glu Gln Gly Ser Cys Lys
Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu 355 360 365 Gly Asp Val Lys Asn
Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu 370 375 380 Arg Pro Ser
Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 385 390 395 400
Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 405
410 415 Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser
Asp 420 425 430 Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp
Gln Leu Ala 435 440 445 Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser
Gly Phe His Gly Ser 450 455 460 Asp Asn Val Phe Ser Asn Met Gln Ala
Leu Phe Val Gly Tyr Gly Pro 465 470 475 480 Gly Phe Lys His Gly Ile
Glu Ala Asp Thr Phe Glu Asn Ile Glu Val 485 490 495 Tyr Asn Leu Met
Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn 500 505 510 Gly Thr
His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 515 520 525
Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 530
535 540 Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile
Leu 545 550 555 560 Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr
Val Ala Glu Glu 565 570 575 Lys Ile Ile Lys His Glu Thr Leu Pro Tyr
Gly Arg Pro Arg Val Leu 580 585 590 Gln Lys Glu Asn Thr Ile Cys Leu
Leu Ser Gln His Gln Phe Met Ser 595 600 605 Gly Tyr Ser Gln Asp Ile
Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 610 615 620 Asp Arg Asn Asp
Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr 625 630 635 640 Gln
Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 645 650
655 Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu
660 665 670 Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr
Thr Asn 675 680 685 Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp
Arg Tyr Phe His 690 695 700 Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu
Arg Asn Gly Val Asn Val 705 710 715 720 Val Ser Gly Pro Val Phe Asp
Phe Asp Tyr Asp Gly Arg Cys Asp Ser 725 730 735 Leu Glu Asn Leu Arg
Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile 740 745 750 Leu Ile Pro
Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 755 760 765 Ser
Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 770 775
780 Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His
785 790 795 800 Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg
Ala Arg Ile 805 810 815 Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe
Tyr Gln Gln Arg Lys 820 825 830 Glu Pro Val Ser Asp Ile Leu Lys Leu
Lys Thr His Leu Pro Thr Phe 835 840 845 Ser Gln Glu Asp Asp Asp Asp
Asp Asp Asp Asp 850 855 1510PRTArtificial sequenceSynthetic 15Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 16232PRTArtificial
sequenceSynthetic 16Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala 1 5 10 15 Pro Glu Ala Ala Gly Ala Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100
105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys 225 230 17662PRTArtificial
sequenceSynthetic 17Ile Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser
Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro Ser Met Ala Ser Met Glu
Pro Lys Ser Cys Asp Lys 20 25 30 Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Ala Ala Gly Ala Pro 35 40 45 Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 50 55 60 Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 65 70 75 80 Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 85 90 95
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 100
105 110 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu 115 120 125 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys 130 135 140 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr 145 150 155 160 Leu Pro Pro Ser Arg Glu Glu Met
Thr Lys Asn Gln Val Ser Leu Thr 165 170 175 Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 180 185 190 Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 195 200 205 Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 210 215 220
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 225
230 235 240 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly 245 250 255 Lys Asp Asp Asp Asp Asp Asp Asp Asp Gly Gly Gly
Gly Ser Gly Gly 260 265 270 Gly Gly Ser Ala Gly Phe Glu Thr Pro Pro
Thr Leu Leu Phe Ser Leu 275 280 285 Asp Gly Phe Arg Ala Glu Tyr Leu
His Thr Trp Gly Gly Leu Leu Pro 290 295 300 Val Ile Ser Lys Leu Lys
Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg 305 310 315 320 Pro Val Tyr
Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr 325 330 335 Gly
Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp 340 345
350 Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn
355 360 365 Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys
Tyr Gln 370 375 380 Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser
Asp Val Glu Ile 385 390 395 400 Asn Gly Ile Phe Pro Asp Ile Tyr Lys
Met Tyr Asn Gly Ser Val Pro 405 410 415 Phe Glu Glu Arg Ile Leu Ala
Val Leu Gln Trp Leu Gln Leu Pro Lys 420 425 430 Asp Glu Arg Pro His
Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser 435 440 445 Ser Gly His
Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu 450 455 460 Gln
Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu 465 470
475 480 Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His
Gly 485 490 495 Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn
Lys Tyr Leu 500 505 510 Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly
Pro Ala Ala Arg Leu 515 520 525 Arg Pro Ser Asp Val Pro Asp Lys Tyr
Tyr Ser Phe Asn Tyr Glu Gly 530 535 540 Ile Ala Arg Asn Leu Ser Cys
Arg Glu Pro Asn Gln His Phe Lys Pro 545 550 555 560 Tyr Leu Lys His
Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp 565 570 575 Arg Ile
Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala 580 585 590
Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser 595
600 605 Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly
Pro 610 615 620 Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn
Ile Glu Val 625 630 635 640 Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu
Thr Pro Ala Pro Asn Asn 645 650 655 Gly Thr His Gly Ser Leu 660
18662PRTArtificial sequenceSynthetic 18Ile Gly Val Leu Leu Thr Gln
Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro Ser
Met Ala Ser Met Glu Pro Lys Ser Cys Asp Lys 20 25 30 Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 35 40 45 Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 50 55
60 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
65 70 75 80 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn 85 90 95 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val 100 105 110 Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu 115 120 125 Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys 130 135 140 Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 145 150 155 160 Leu Pro
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 165 170 175
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 180
185 190 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu 195 200 205 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys 210 215 220 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu 225 230 235 240 Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly 245 250 255 Lys Ala Gly Phe Glu Thr
Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly 260 265 270 Phe Arg Ala Glu
Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile 275 280 285 Ser Lys
Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val 290 295 300
Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu 305
310 315 320 Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp
Pro Lys 325 330 335 Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys
Phe Asn Pro Glu 340 345 350 Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr
Ala Lys Tyr Gln Gly Leu 355 360 365 Lys Ser Gly Thr Phe Phe Trp Pro
Gly Ser Asp Val Glu Ile Asn Gly 370 375 380 Ile Phe Pro Asp Ile Tyr
Lys Met Tyr Asn Gly Ser Val Pro Phe Glu 385 390 395 400 Glu Arg Ile
Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu 405 410 415 Arg
Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly 420 425
430 His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg
435 440 445 Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu
Leu Asn 450 455 460 Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp
His Gly Met Glu 465 470 475 480 Gln Gly Ser Cys Lys Lys Tyr Ile Tyr
Leu Asn Lys Tyr Leu Gly Asp 485 490 495 Val Lys Asn Ile Lys Val Ile
Tyr Gly Pro Ala Ala Arg Leu Arg Pro 500 505 510 Ser Asp Val Pro Asp
Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala 515 520 525 Arg Asn Leu
Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu 530 535 540 Lys
His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile 545 550
555 560 Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu
Asn 565 570 575 Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly
Ser Asp Asn 580 585 590 Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly
Tyr Gly Pro Gly Phe 595 600 605 Lys His Gly Ile Glu Ala Asp Thr Phe
Glu Asn Ile Glu Val Tyr Asn 610 615 620 Leu Met Cys Asp Leu Leu Asn
Leu Thr Pro Ala Pro Asn Asn Gly Thr 625 630 635 640 His Gly Ser Leu
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Asp 645 650 655 Asp Asp
Asp Asp Asp Asp 660 192580DNAArtificial sequenceSynthetic
19atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca
60agcatggcga gcatgccaag ttgtgccaaa gaagttaaaa gttgcaaagg tcgctgtttc
120gagagaacat ttgggaactg tcgctgtgat gctgcctgtg ttgagcttgg
aaactgctgt 180ttggattacc aggagacgtg catagaacca gaacatatat
ggacttgcaa caaattcagg 240tgtggtgaga aaagattgac cagaagcctc
tgtgcctgtt cagatgattg caaggacaag 300ggcgactgct gcatcaacta
cagttcagtg tgtcaaggtg agaaaagttg ggtggaagaa 360ccatgtgaga
gcattaatga gccacagtgc ccagcagggt ttgaaacgcc tcctacactc
420ttgttttctt tggatggatt cagggcagaa tatttgcaca cttggggtgg
acttcttcct 480gttattagca aactcaaaaa atgtggaaca tatactaaaa
acatgagacc ggtgtatcca 540acaaaaactt tccccaatca ctacagcatt
gtcaccggat tgtatccaga atctcatggc 600ataatcgaca ataagatgta
tgatcccaaa atgaatgctt ccttttcact taaaagtaaa 660gagaaattta
atccggagtg gtacaaagga gaaccaattt gggtcacagc taagtatcaa
720ggcctcaagt ctggcacatt tttctggcca ggatcagatg tggaaattaa
cggaattttc 780ccagacatct ataaaatgta taatggttca gtgccatttg
aagaaaggat tttggctgtt 840cttcagtggc tgcagcttcc aaaagatgaa
agaccacact tttacacttt gtatttggaa 900gaaccagatt cttcaggtca
ttcatatgga ccagtcagca gtgaagtcat caaagccttg 960cagagggttg
atggtatggt tggtatgctg atggatggtc tgaaagagct gaacttgcac
1020agatgcctga acctcatcct tatttcagat catggcatgg aacaaggcag
ttgtaagaaa 1080tacatatatc tgaataagta tttgggggat gttaaaaata
ttaaagttat ctatggacct 1140gcagctcgat tgagaccctc tgatgtccca
gataaatact attcatttaa ctatgaaggc 1200attgcccgaa atctttcttg
ccgggaacca aaccagcact tcaaacctta tctgaaacat 1260ttcttgccta
agcgtttgca ctttgctaag agtgatagaa ttgagccctt gacattctat
1320ttggaccctc agtggcaact tgcattgaat ccctcagaaa ggaaatattg
tggaagtgga 1380tttcatggct ctgacaatgt gttttcaaat atgcaagccc
tctttgttgg ctatggacct 1440ggattcaagc atggcattga ggctgacacc
tttgaaaaca ttgaagtcta taacttgatg 1500tgtgatttgc tgaatttgac
accggctcct aataacggaa ctcatggaag tcttaaccac 1560cttctgaaga
atcctgttta tacgccaaag catcccaaag aagtgcaccc cctggtgcag
1620tgccccttca caagaaaccc cagagataac cttggctgct catgtaaccc
ttccattttg 1680ccgattgagg attttcaaac acagttcaat ctgaccgtgg
cagaagagaa gattattaag 1740catgaaactt tgccctatgg aagacctaga
gttctccaga aggaaaacac catctgtctt 1800ctttcccagc accagtttat
gagtggatac agccaagaca tcttgatgcc cctttggaca 1860tcctataccg
tggacagaaa tgacagtttc tctacggaag acttctccaa ctgtctgtac
1920caggacttta gaattcctct tagtcctgtc cataaatgtt cattttataa
aaataacacc 1980aaagtgagtt acgggttcct ctccccacca caactgaata
agaattcaag tggaatatat 2040tctgaagcct tgcttactac aaatatagtg
ccaatgtacc agagttttca agttatatgg 2100cgctactttc atgacaccct
cttgcgaaag tatgcagaag aaagaaatgg tgtcaatgtc 2160gtcagtggtc
ctgtgtttga ctttgattat gatggacgtt gtgattcctt ggagaatttg
2220aggcaaaaaa gaagagtcat ccgtaaccaa gaaattttga ttccaactca
tttcttcatt 2280gtgctgacaa gctgtaaaga tacatctcag acgcctttgc
actgtgaaaa cctggacacc 2340ttggctttca ttttgcctca caggactgat
aacagcgaga gctgtgtgca tgggaagcat 2400gactcctcat gggttgaaga
attgttgatg ttgcacagag cacggatcac agacgtcgag 2460cacatcactg
gactcagctt ttatcaacaa agaaaagagc cagtttcaga cattttgaag
2520ttgaaaacac atttgccaac ctttagccaa gaagatgatg acgatgatga
cgacgattga 258020859PRTArtificial sequenceSynthetic 20Met Gly Val
Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu
Leu Phe Pro Ser Met Ala Ser Met Pro Ser Cys Ala Lys Glu Val 20 25
30 Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg
35 40 45 Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp
Tyr Gln 50 55 60 Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys
Asn Lys Phe Arg 65 70 75 80 Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu
Cys Ala Cys Ser Asp Asp 85 90 95 Cys Lys Asp Lys Gly Asp Cys Cys
Ile Asn Tyr Ser Ser Val Cys Gln 100 105 110 Gly Glu Lys Ser Trp Val
Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro 115 120 125 Gln Cys Pro Ala
Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu 130 135 140 Asp Gly
Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 145 150 155
160 Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg
165 170 175 Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile
Val Thr 180 185 190 Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn
Lys Met Tyr Asp 195 200 205 Pro Lys Met Asn Ala Ser Phe Ser Leu Lys
Ser Lys Glu Lys Phe Asn 210 215 220 Pro Glu Trp Tyr Lys Gly Glu Pro
Ile Trp Val Thr Ala Lys Tyr Gln 225 230 235 240 Gly Leu Lys Ser Gly
Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile 245 250 255 Asn Gly Ile
Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 260 265 270 Phe
Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 275 280
285 Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser
290 295 300 Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys
Ala Leu 305 310 315 320 Gln Arg Val Asp Gly Met Val Gly Met Leu Met
Asp Gly Leu Lys Glu 325 330 335 Leu Asn Leu His Arg Cys Leu Asn Leu
Ile Leu Ile Ser Asp His Gly 340 345 350 Met Glu Gln Gly Ser Cys Lys
Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu 355 360 365 Gly Asp Val Lys Asn
Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu 370 375 380 Arg Pro Ser
Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 385 390 395 400
Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 405
410 415 Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser
Asp 420 425 430 Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp
Gln Leu Ala 435 440 445 Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser
Gly Phe His Gly Ser 450 455 460 Asp Asn Val Phe Ser Asn Met Gln Ala
Leu Phe Val Gly Tyr Gly Pro 465 470 475 480 Gly Phe Lys His Gly Ile
Glu Ala Asp Thr Phe Glu Asn Ile Glu Val 485 490 495 Tyr Asn Leu Met
Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn 500 505 510 Gly Thr
His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 515 520 525
Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 530
535 540 Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile
Leu 545 550 555 560 Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr
Val Ala Glu Glu 565 570 575 Lys Ile Ile Lys His Glu Thr Leu Pro Tyr
Gly Arg Pro Arg Val Leu 580 585 590 Gln Lys Glu Asn Thr Ile Cys Leu
Leu Ser Gln His Gln Phe Met Ser 595 600 605 Gly Tyr Ser Gln Asp Ile
Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 610 615 620 Asp Arg Asn Asp
Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr 625 630 635 640 Gln
Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 645 650
655 Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu
660 665 670 Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr
Thr Asn 675 680 685 Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp
Arg Tyr Phe His 690 695 700 Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu
Arg Asn Gly Val Asn Val 705 710 715 720 Val Ser Gly Pro Val Phe Asp
Phe Asp Tyr Asp Gly Arg Cys Asp Ser 725 730 735 Leu Glu Asn Leu Arg
Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile 740 745 750 Leu Ile Pro
Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 755 760 765 Ser
Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 770 775
780 Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His
785 790 795 800 Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg
Ala Arg Ile 805 810 815 Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe
Tyr Gln Gln Arg Lys 820 825 830 Glu Pro Val Ser Asp Ile Leu Lys Leu
Lys Thr His Leu Pro Thr Phe 835 840 845 Ser Gln Glu Asp Asp Asp Asp
Asp Asp Asp Asp 850 855 213255DNAArtificial sequenceSynthetic
21atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca
60agcatggcga gcatgccaag ttgtgccaaa gaagttaaaa gttgcaaagg tcgctgtttc
120gagagaacat ttgggaactg tcgctgtgat gctgcctgtg ttgagcttgg
aaactgctgt 180ttggattacc aggagacgtg catagaacca gaacatatat
ggacttgcaa caaattcagg 240tgtggtgaga aaagattgac cagaagcctc
tgtgcctgtt cagatgattg caaggacaag 300ggcgactgct gcatcaacta
cagttcagtg tgtcaaggtg agaaaagttg ggtggaagaa 360ccatgtgaga
gcattaatga gccacagtgc ccagcagggt ttgaaacgcc tcctacactc
420ttgttttctt tggatggatt cagggcagaa tatttgcaca cttggggtgg
acttcttcct 480gttattagca aactcaaaaa atgtggaaca tatactaaaa
acatgagacc ggtgtatcca 540acaaaaactt tccccaatca ctacagcatt
gtcaccggat tgtatccaga atctcatggc 600ataatcgaca ataagatgta
tgatcccaaa atgaatgctt ccttttcact taaaagtaaa 660gagaaattta
atccggagtg gtacaaagga gaaccaattt gggtcacagc taagtatcaa
720ggcctcaagt ctggcacatt tttctggcca ggatcagatg tggaaattaa
cggaattttc 780ccagacatct ataaaatgta taatggttca gtgccatttg
aagaaaggat tttggctgtt 840cttcagtggc tgcagcttcc aaaagatgaa
agaccacact tttacacttt gtatttggaa 900gaaccagatt cttcaggtca
ttcatatgga ccagtcagca gtgaagtcat caaagccttg 960cagagggttg
atggtatggt tggtatgctg atggatggtc tgaaagagct gaacttgcac
1020agatgcctga acctcatcct tatttcagat catggcatgg aacaaggcag
ttgtaagaaa 1080tacatatatc tgaataagta tttgggggat gttaaaaata
ttaaagttat ctatggacct 1140gcagctcgat tgagaccctc tgatgtccca
gataaatact attcatttaa ctatgaaggc 1200attgcccgaa atctttcttg
ccgggaacca aaccagcact tcaaacctta tctgaaacat 1260ttcttgccta
agcgtttgca ctttgctaag agtgatagaa ttgagccctt gacattctat
1320ttggaccctc agtggcaact tgcattgaat ccctcagaaa ggaaatattg
tggaagtgga 1380tttcatggct ctgacaatgt gttttcaaat atgcaagccc
tctttgttgg ctatggacct 1440ggattcaagc atggcattga ggctgacacc
tttgaaaaca ttgaagtcta taacttgatg 1500tgtgatttgc tgaatttgac
accggctcct aataacggaa ctcatggaag tcttaaccac 1560cttctgaaga
atcctgttta tacgccaaag catcccaaag aagtgcaccc cctggtgcag
1620tgccccttca caagaaaccc cagagataac cttggctgct catgtaaccc
ttccattttg 1680ccgattgagg attttcaaac acagttcaat ctgaccgtgg
cagaagagaa gattattaag 1740catgaaactt tgccctatgg aagacctaga
gttctccaga aggaaaacac catctgtctt 1800ctttcccagc accagtttat
gagtggatac agccaagaca tcttgatgcc cctttggaca 1860tcctataccg
tggacagaaa tgacagtttc tctacggaag acttctccaa ctgtctgtac
1920caggacttta gaattcctct tagtcctgtc cataaatgtt cattttataa
aaataacacc 1980aaagtgagtt acgggttcct ctccccacca caactgaata
agaattcaag tggaatatat 2040tctgaagcct tgcttactac aaatatagtg
ccaatgtacc agagttttca agttatatgg 2100cgctactttc atgacaccct
cttgcgaaag tatgcagaag aaagaaatgg tgtcaatgtc 2160gtcagtggtc
ctgtgtttga ctttgattat gatggacgtt gtgattcctt ggagaatttg
2220aggcaaaaaa gaagagtcat ccgtaaccaa gaaattttga ttccaactca
tttcttcatt 2280gtgctgacaa gctgtaaaga tacatctcag acgcctttgc
actgtgaaaa cctggacacc 2340ttggctttca ttttgcctca caggactgat
aacagcgaga gctgtgtgca tgggaagcat 2400gactcctcat gggttgaaga
attgttgatg ttgcacagag cacggatcac agacgtcgag 2460cacatcactg
gactcagctt ttatcaacaa agaaaagagc cagtttcaga cattttgaag
2520ttgaaaacac atttgccaac ctttagccaa gaagatgagc ccaaatcttg
tgacaaaact 2580cacacatgcc caccgtgccc agcacctgaa ctcctggggg
gaccgtcagt cttcctcttc 2640cccccaaaac ccaaggacac cctcatgatc
tcccggaccc ctgaggtcac atgcgtggtg 2700gtggacgtga gccacgaaga
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 2760gtgcataatg
ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc
2820agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa
gtgcaaggtc 2880tccaacaaag ccctcccagc ccccatcgag aaaaccatct
ccaaagccaa agggcagccc 2940cgagaaccac aggtgtacac cctgccccca
tcccgggagg agatgaccaa gaaccaggtc 3000agcctgacct gcctggtcaa
aggcttctat cccagcgaca tcgccgtgga gtgggagagc 3060aatgggcagc
cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc
3120ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg
gaacgtcttc 3180tcatgctccg tgatgcatga
ggctctgcac aaccactaca cgcagaagag cctctccctg 3240tccccgggta aatga
3255221084PRTArtificial sequenceSynthetic 22Met Gly Val Leu Leu Thr
Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 1 5 10 15 Leu Leu Phe Pro
Ser Met Ala Ser Met Pro Ser Cys Ala Lys Glu Val 20 25 30 Lys Ser
Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg 35 40 45
Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln 50
55 60 Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe
Arg 65 70 75 80 Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys
Ser Asp Asp 85 90 95 Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn Tyr
Ser Ser Val Cys Gln 100 105 110 Gly Glu Lys Ser Trp Val Glu Glu Pro
Cys Glu Ser Ile Asn Glu Pro 115 120 125 Gln Cys Pro Ala Gly Phe Glu
Thr Pro Pro Thr Leu Leu Phe Ser Leu 130 135 140 Asp Gly Phe Arg Ala
Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 145 150 155 160 Val Ile
Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg 165 170 175
Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr 180
185 190 Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr
Asp 195 200 205 Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu
Lys Phe Asn 210 215 220 Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val
Thr Ala Lys Tyr Gln 225 230 235 240 Gly Leu Lys Ser Gly Thr Phe Phe
Trp Pro Gly Ser Asp Val Glu Ile 245 250 255 Asn Gly Ile Phe Pro Asp
Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 260 265 270 Phe Glu Glu Arg
Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 275 280 285 Asp Glu
Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser 290 295 300
Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu 305
310 315 320 Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu
Lys Glu 325 330 335 Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile
Ser Asp His Gly 340 345 350 Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile
Tyr Leu Asn Lys Tyr Leu 355 360 365 Gly Asp Val Lys Asn Ile Lys Val
Ile Tyr Gly Pro Ala Ala Arg Leu 370 375 380 Arg Pro Ser Asp Val Pro
Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 385 390 395 400 Ile Ala Arg
Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 405 410 415 Tyr
Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp 420 425
430 Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala
435 440 445 Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His
Gly Ser 450 455 460 Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val
Gly Tyr Gly Pro 465 470 475 480 Gly Phe Lys His Gly Ile Glu Ala Asp
Thr Phe Glu Asn Ile Glu Val 485 490 495 Tyr Asn Leu Met Cys Asp Leu
Leu Asn Leu Thr Pro Ala Pro Asn Asn 500 505 510 Gly Thr His Gly Ser
Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 515 520 525 Pro Lys His
Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 530 535 540 Arg
Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu 545 550
555 560 Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu
Glu 565 570 575 Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro
Arg Val Leu 580 585 590 Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln
His Gln Phe Met Ser 595 600 605 Gly Tyr Ser Gln Asp Ile Leu Met Pro
Leu Trp Thr Ser Tyr Thr Val 610 615 620 Asp Arg Asn Asp Ser Phe Ser
Thr Glu Asp Phe Ser Asn Cys Leu Tyr 625 630 635 640 Gln Asp Phe Arg
Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 645 650 655 Lys Asn
Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu 660 665 670
Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn 675
680 685 Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe
His 690 695 700 Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly
Val Asn Val 705 710 715 720 Val Ser Gly Pro Val Phe Asp Phe Asp Tyr
Asp Gly Arg Cys Asp Ser 725 730 735 Leu Glu Asn Leu Arg Gln Lys Arg
Arg Val Ile Arg Asn Gln Glu Ile 740 745 750 Leu Ile Pro Thr His Phe
Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 755 760 765 Ser Gln Thr Pro
Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 770 775 780 Leu Pro
His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His 785 790 795
800 Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile
805 810 815 Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln
Arg Lys 820 825 830 Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His
Leu Pro Thr Phe 835 840 845 Ser Gln Glu Asp Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys Pro 850 855 860 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 865 870 875 880 Pro Pro Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 885 890 895 Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 900 905 910 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 915 920
925 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
930 935 940 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 945 950 955 960 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
Thr Ile Ser Lys Ala 965 970 975 Lys Gly Gln Pro Arg Glu Pro Gln Val
Tyr Thr Leu Pro Pro Ser Arg 980 985 990 Glu Glu Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 995 1000 1005 Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 1010 1015 1020 Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 1025 1030 1035
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 1040
1045 1050 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala 1055 1060 1065 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly 1070 1075 1080 Lys
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