U.S. patent application number 14/288890 was filed with the patent office on 2014-10-23 for longitudinal dermoscopic study employing smartphone-based image registration.
The applicant listed for this patent is Digimarc Corporation. Invention is credited to Bruce L. Davis, Geoffrey B. Rhoads, Tony F. Rodriguez.
Application Number | 20140313303 14/288890 |
Document ID | / |
Family ID | 51728691 |
Filed Date | 2014-10-23 |
United States Patent
Application |
20140313303 |
Kind Code |
A1 |
Davis; Bruce L. ; et
al. |
October 23, 2014 |
LONGITUDINAL DERMOSCOPIC STUDY EMPLOYING SMARTPHONE-BASED IMAGE
REGISTRATION
Abstract
The evolution of a skin condition over time can be useful in its
assessment. In an illustrative arrangement, a user captures skin
images at different times, using a smartphone. The images are
co-registered, color-corrected, and presented to the user (or a
clinician) for review, e.g., in a temporal sequence, or as one
image presented as a ghosted overlay atop another. Image
registration can employ nevi, hair follicles, wrinkles, pores, and
pigmented regions as keypoints. With some imaging spectra,
keypoints from below the outermost layer of skin can be used. Hair
may be removed for image registration, and restored for image
review. Transformations in addition to rotation and affine
transforms can be employed. Diagnostic correlations with reference
image sequences can be made, employing machine learning in some
instances. A great variety of other features and arrangements are
also detailed.
Inventors: |
Davis; Bruce L.; (Lake
Oswego, OR) ; Rodriguez; Tony F.; (Portland, OR)
; Rhoads; Geoffrey B.; (West Linn, OR) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
Digimarc Corporation |
Beaverton |
OR |
US |
|
|
Family ID: |
51728691 |
Appl. No.: |
14/288890 |
Filed: |
May 28, 2014 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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14276578 |
May 13, 2014 |
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14288890 |
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PCT/US14/34706 |
Apr 18, 2014 |
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14276578 |
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14206109 |
Mar 12, 2014 |
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14276578 |
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61978632 |
Apr 11, 2014 |
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61813295 |
Apr 18, 2013 |
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61832715 |
Jun 7, 2013 |
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61836560 |
Jun 18, 2013 |
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61872494 |
Aug 30, 2013 |
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Current U.S.
Class: |
348/77 |
Current CPC
Class: |
A61B 5/0002 20130101;
A61B 5/0077 20130101; G06T 2210/41 20130101; G06T 7/33 20170101;
A61B 5/68 20130101; G06T 2207/30088 20130101; A61B 5/444 20130101;
G06K 9/00885 20130101; G06T 7/0016 20130101; A61B 5/7425
20130101 |
Class at
Publication: |
348/77 |
International
Class: |
G06T 3/00 20060101
G06T003/00; A61B 5/00 20060101 A61B005/00; H04N 5/232 20060101
H04N005/232 |
Claims
1. A method comprising the acts: capturing a first image of skin at
a first time, using a camera of a smartphone; capturing a second
image of said skin at a second time later than the first time;
identifying plural features in one of said images; locating said
plural features in the other of said images; transforming one or
more of said images to co-register said plural features
therebetween; and after said transforming, presenting a time-based
sequence of images, on a display of the smartphone, to a
viewer.
2. The method of claim 1 that further includes capturing a third
image of said skin at a third time later than the second time, and
including said third image in said presented time-based sequence of
images.
3. The method of claim 1 in which said plural features comprise one
or more nevi.
4. The method of claim 1 in which said plural features comprise one
or more hair follicles.
5. The method of claim 1 in which said plural features comprise one
or more wrinkles.
6. The method of claim 1 in which said plural features comprise one
or more pigmented regions.
7. The method of claim 1 in which said plural features include one
or more features from below an outermost layer of skin.
8. The method of claim 1 that includes determining an area of a
lesion on said skin, and avoiding said area in identifying said
plural features.
9. The method of claim 8 that includes flooding said area with a
uniform color, so that features are not identified therein.
10. The method of claim 1 that includes processing said captured
images to remove depictions of hair therein before identifying and
locating said plural features.
11. The method of claim 10 wherein said time-based sequence of
images presented to the viewer includes depictions of hair.
12. The method of claim 1 in which said transforming further
includes applying color correction to one or more of said
images.
13. The method of claim 1 in which said presenting includes
presenting different images in said sequence in response to a
sliding-finger motion by the viewer on said display.
14. The method of claim 1 in which said transforming includes a
transformation other than rotation and/or affine transformation, to
account for curvature of a surface of the skin.
15. The method of claim 1 that includes presenting one of said
presented images for a first duration, and presenting another of
said presented images for a second duration different than the
first duration, in accordance with spans of time between captures
of different images.
16. The method of claim 1 that includes overlaying measurement
information on said presented sequence of images.
17. The method of claim 1 in which said presenting includes
overlaying one of said images on another of said images, as a
ghosted augmentation.
18. The method of claim 17 that further includes displaying a user
interface that enables the viewer to select a particular image for
said overlaying.
19. The method of claim 1 that includes analyzing said time-based
sequence of images by comparing associated data with information
from reference time-based sequences, for diagnostic purposes.
20. The method of claim 1 in which at least one of said images
includes color data other than red, green or blue.
21. A method comprising the acts: capturing a first image of skin
at a first time; capturing a live image of said skin at a second
time later than the first time; identifying plural features in one
of said images; locating said plural features in the other of said
images; transforming one of said images to co-register said plural
features between the first and live images; and presenting said
first and live images, after said transforming, on a display to a
viewer.
22. The method of claim 21 in which said presenting includes
presenting one of said images as a ghosted overlay on the other of
said images.
23. The method of claim 21 in which said plural features comprise
features selected from the list consisting of nevi, hair follicles,
wrinkles, pores, pigmented regions, and skin textures.
24. The method of claim 21 in which said plural features include
one or more features from below an outermost layer of skin.
25. The method of claim 21 in which said transforming employs a
hardware processor in a smartphone.
26. The method of claim 21 that includes determining an area of a
lesion on said skin, and avoiding said area in identifying said
plural features.
27. The method of claim 21 that includes processing said captured
images to remove depictions of hair therein before identifying and
locating said plural features.
28. The method of claim 27 wherein said presented images include
depictions of hair.
29. The method of claim 21 in which said transforming includes a
transformation other than rotation and/or affine transformation, to
account for curvature of a surface of the skin.
30. The method of claim 21 that further includes: capturing another
image of said skin at a time between the first and second times;
locating said plural features in said another image; transforming
said another image to co-register said another image with the first
and live images; and including said transformed another image in
said presentation of images on the display to the viewer.
31. A non-transitory computer readable medium containing software
instructions for configuring one or more processors of a smartphone
to perform acts including: capturing a first image of skin at a
first time, using a camera of the smartphone; capturing a second
image of said skin at a second time later than the first time;
identifying plural features in one of said images; locating said
plural features in the other of said images; transforming one or
more of said images to co-register said plural features
therebetween; and after said transforming, presenting a time-based
sequence of images, on a display of the smartphone, to a viewer.
Description
RELATED APPLICATION DATA
[0001] This application is a division of application Ser. No.
14/276,578, filed May 13, 2014, which is a continuation of
international application PCT/US14/34706, filed Apr. 18, 2014,
which claims priority to provisional application 61/978,632, filed
Apr. 11, 2014. Application Ser. No. 14/276,578 is also a
continuation-in-part of application Ser. No. 14/206,109, filed Mar.
12, 2014, which claims priority to provisional applications
61/813,295, filed Apr. 18, 2013; 61/832,715, filed Jun. 7, 2013;
61/836,560, filed Jun. 18, 2013; and 61/872,494, filed Aug. 30,
2013. These applications are incorporated herein by reference.
INTRODUCTION
[0002] Medical diagnosis is an uncertain art, which depends largely
on the skill and experience of the practitioner. For example,
dermatological diagnosis tends to be based on very casual
techniques, like observation by doctor, or on very invasive
techniques, like biopsies. Skin condition degrades with age. It is
difficult for people to differentiate the effects of normal aging
from disease. This leads to lots of worry and unnecessary doctor
visits. More rigorous diagnostic techniques can be applied to
educate the public, assist medical professionals, and lower health
care costs.
[0003] An example is diagnosis of diseases evidenced by skin rashes
and other dermatological symptoms. A skilled dermatologist may be
able to accurately identify dozens of obscure conditions by their
appearance, whereas a general practitioner may find even some
common rashes to be confounding. But highly skilled practitioners
are sometimes puzzled, e.g., when a rash appears on a traveler
recently returned from the tropics, and the practitioner has no
experience with tropical medicine.
[0004] Some of the dimensions of differential diagnosis in
dermatology include location on body, color, texture, shape, and
distribution. Other relevant factors include age, race, sex, family
tree, and geography of person; and environmental factors including
diet, medications, exposure to sun, and occupation. Many skin
conditions have topologies and geographies that can be mapped in
various dimensions, including depth, color and texture.
[0005] The prior art includes smartphone apps that are said to be
useful in diagnosing skin cancer. Some rely on computerized image
analysis. Others refer smartphone snapshots to a nurse or physician
for review. The former have been found to perform very poorly. See,
e.g., Wolf et al, Diagnostic Inaccuracy of Smartphone Applications
for Melanoma Detection, JAMA Dermatology, Vol. 149, No. 4, April
2013 (attached to application 61/872,494).
[0006] In accordance with one embodiment of the present technology,
imagery of dermatological conditions and other enrollment
information is compiled in a crowd-sourced database, together with
associated diagnosis information. This reference information may be
contributed by physicians and other medical personnel, but can also
be provided by the lay public (e.g., relaying a diagnosis provided
by a doctor).
[0007] A user submits a query image to the system (typically with
anonymous enrollment/contextual information, such as age, gender,
location, and possibly medical history, etc.). Image-based
derivatives are determined (e.g., color histograms, FFT-based
metrics, etc.) for the query image, and are compared against
similar derivatives for the reference imagery. In one arrangement,
those reference images whose derivatives most closely correspond to
the query image are determined, and their associated diagnoses are
identified. This information is presented to the user in a ranked
listing of possible pathologies. In some embodiments, when the
user's submitted query image and associated information is analyzed
by the system and several likely diagnoses identified, the system
may provide specific questions (guided by the results of the
current analysis) to the user, or requests for additional images,
to help distinguish among the candidate diagnoses.
[0008] In a variant arrangement, the analysis identifies diseases
that are not consistent with the query image and associated
information. Again, this information is reported to the user
(expressly; not simply by omission) and may include a risk profile
that conveys statistical and/or qualitative measures of risk about
such information.
[0009] In some embodiments, the imagery is supplemented with 3D
information about the surface topology of the skin, and this
information is used in the matching process. Such 3D information
can be derived from the imagery, or may be separately sensed.
[0010] Depending on the specificity of the data, and the size of
the crowd-sourced database, 90%, 98%, or more of candidate
conditions can be effectively ruled-out through such methods. A
professional using such technology may thus be able to spare a
patient expensive and painful testing (e.g., biopsies), because the
tested-for conditions can be reliably screened by reference to the
large corpus of reference imagery and associated knowledge
generated by the system. Similarly, a worried user may be relieved
to quickly learn, for example, that an emerging pattern of small
lesions on a forearm is probably not caused by shingles, bedbugs,
malaria or AIDs.
[0011] In some embodiments, the knowledge base includes profile
information about the subjects whose skin conditions are depicted.
This profile information can include, e.g., drugs they are taking,
places they have visited in the days leading up to onset of
symptoms, medical history, lifestyle habits, etc. When a user
submits a query image, and the system identifies reference imagery
having matching derivatives, the system can also report
statistically-significant co-occurrence information derived from
the profile information. For example, the system may report that
27% of people having a skin condition like that depicted in the
user's query image report taking vitamin A supplements.
[0012] In some embodiments, the co-occurrence information is broken
down by candidate diagnoses. For example, the system may report
that the top candidate diagnosis is miliaria X (42% chance). 35% of
people with this diagnosis report having been in the tropics in the
30 days prior to onset of symptoms, and 25% report occasional use
of hot tubs or saunas. The next top candidate diagnosis is tinea Y
(28% chance). 60% of people with this diagnosis report having
chicken pox as a child. Such co-occurrence information can help in
making a differential diagnosis from among the offered
alternatives.
[0013] Sometimes a patient is less concerned with the diagnosis
than simply wanting to be rid of an affliction. Thus, some
embodiments of the technology do not attempt to identify, or
rule-out, particular diagnoses. Instead, they simply seek to
identify correlated factors from the knowledge base created from
information from users, image analysis, and crowd-sourced data, so
that possibly causative factors might be addressed (e.g., by
suspending intake of supplemental vitamin A, in the example given
above).
[0014] Typically, the user-submitted information is added to the
knowledge base, and forms part of the reference information against
which future submissions are analyzed.
[0015] While described primarily in the context of skin imagery,
the principles of the present technology are likewise applicable
with any physiologically-derived signals. An example is audio.
Audio signals include heart sounds and other cardiovascular sounds
(including murmurs, bruits, and other blood flow noises), lung and
other respiratory sounds (including crackles, rales, rhonchi,
wheezes, coughs, snoring and other air flow noises), bowel and
digestive sounds, joint noises (e.g., pops and creaks), as well as
speech and other vocalizations.
[0016] The foregoing and other features and advantages of the
present technology will be more readily apparent from the following
detailed description, which proceeds with reference to the
accompanying figures.
BRIEF DESCRIPTION OF THE DRAWINGS
[0017] FIG. 1 illustrates components of one implementation of the
technology, including plural remote terminals (e.g., smartphones),
and one or more central systems.
[0018] FIG. 2 illustrates conceptual organization of an exemplary
diagnostic system using technology disclosed herein.
[0019] FIG. 3A shows a banknote, and FIG. 3B shows an excerpt from
the banknote.
[0020] FIG. 4 shows normalized reflectance plots for the FIG. 3B
banknote excerpt, and for a white envelope.
[0021] FIG. 5 is a schematic sectional view of a full-body imaging
booth.
[0022] FIGS. 6A and 6B are views depicting features of alternate
imaging booths.
[0023] FIGS. 7, 8 and 9 detail sequences of smartphone screen
displays that provide illumination of different spectral
characteristics, from different positions relative to the
smartphone camera.
[0024] FIG. 10 details how light from different parts of a
smartphone screen display illuminates a feature on a skin from
different angles.
DETAILED DESCRIPTION
[0025] FIG. 1 shows a hardware overview of one embodiment employing
principles of the present technology. Included are one or more user
terminals (e.g., smartphones), and a central system.
[0026] As is familiar, each smartphone includes various functional
modules--shown in rectangles. These include one or more processors,
a memory, a camera, and a flash. These latter two elements are
controlled by the processor in accordance with operating system
software and application software stored in the memory.
[0027] The central system similarly includes one or more
processors, a memory, and other conventional components.
Particularly shown in FIG. 1 is a knowledge base--a database data
structure that facilitates storage and retrieval of data used in
the present methods.
[0028] One aspect of the present technology includes the central
system receiving first imagery depicting a part of a human body
that evidences a symptom of a pathological condition (e.g., skin
rash or bumps). This imagery (and its image metadata) can be
uploaded to the central system from one of the user terminals using
commonly available image submission means and enrollment. The image
then is processed to derive one or more image parameter(s). A data
structure containing reference information is then searched, for
reference image data that is parametrically similar to the first
imagery. Based on results of this search, one or more particular
pathological conditions that are not the pathological condition
evidenced by the depicted part of the human body are identified.
Resulting information is then communicated to the originating user
terminal.
[0029] In some cases, it may be useful to present "similar" images
to the user, along with any accompanying diagnoses. In these cases,
it is important to ensure that the presented images are relevant to
the user. In many implementations, a machine learning approach will
be suitable for determining candidate diagnoses. Many features,
whether part of the raw user images, or processed versions thereof,
are presented to the machine learning algorithm. Additional
features, representing age, gender, race, height, weight, etc., are
also likely to be input to the algorithm. The machine learning
algorithm can output a set of candidate diagnoses which best match
the user's images and additional information. If representative
images are to be presented to the user as representative of their
diagnoses, the images should be chosen from the database not just
based upon visual similarity, but also based upon how well the
database image's associated additional features (age, gender, etc.)
match the user.
[0030] (For expository convenience, the terms image, imagery, image
data, and similar words/expressions, are used to encompass
traditional spatial luminance/chrominance representations of a
scene, and also to encompass other information optically captured
from a subject. This can include, for instance, 3D microtopology.
Such terms also encompass such information represented in
non-spatial domains, e.g., FFT data, which represents the
information is a spectral domain.)
[0031] The derived image parameter(s) can be of various types, with
some types being more discriminative for some pathologies, while
other types are more discriminative for others.
[0032] One sample derived image parameter is a color histogram.
This histogram may be normalized by reference to a "normal" skin
color, e.g., as sampled from a periphery of the area exhibiting the
symptom.
[0033] Particular types of suitable color histograms are detailed
in Digimarc's U.S. Pat. No. 8,004,576. One such histogram is a 3D
histogram, in which the first and second histogram dimensions are
quantized hues (e.g., red-green, and blue-yellow), and the third
histogram dimension is a quantized second derivative of
luminance.
[0034] Desirably, the imagery is spectrally accurate, so that
hue-based image derivatives are diagnostically useful. One low cost
approach to acquiring such imagery is by gathering multiple frames
of imagery under different, spectrally tuned illumination
conditions, and processing same, as detailed in co-pending
application Ser. No. 13/840,451, filed Mar. 15, 2013 (now published
as 20130308045), and Ser. No. 14/201,852, filed Mar. 8, 2014.
[0035] Another type of derived image parameter is a transformation
of the imagery into a spatial frequency domain representation
(e.g., FFT data). Such representation decomposes the image into
components of different frequencies, angular orientations, phases
and magnitudes (depending on the manner of representation).
Parameters of this type are particularly useful in discerning skin
textures, which are often useful as diagnostic criteria. The
decomposition of the image into such spatial frequency components
can be conducted separately in different channels, e.g., yielding
two-, three- or more-binned representations of different image
chrominance and luminance planes. (More than the usual tri-color
image representations can be used. For example, the image may be
represented with 4-20 different color channels.)
[0036] Still another image derivative is wavelet transform data.
Such information is again a decomposition of the image information
into a collection of orthonormal basis functions--in this case
wavelets.
[0037] A variety of other domain transformations can similarly be
applied to the imagery to serve as the basis of image metrics for
matching.
[0038] Yet another image derivative is blob analysis. One form of
such analysis involves "region growing." A particular method,
practiced in the pixel domain, involves selecting a seed pixel, and
adding to a blob all of the contiguous pixels whose values are
within a threshold value range of the seed pixel, e.g., plus or
minus three digital numbers in luminance, on a 0-255 scale. This
process can be repeated for seed pixels throughout the image. The
seed pixels can be selected based on color or other parameter
(e.g., a local maxima in image redness or contrast), or may be
chosen randomly. What results is a pattern of 2D regions whose
shape and scale parameters are useful as diagnostic indicia.
[0039] A particular image metric derived from blob analysis is a
histogram identifying frequency of occurrence of different shapes.
Shapes may be classified in various fashions. A simple two-class
division, for example, may distinguish shapes that have exclusively
convex boundaries (e.g., circles and ovoids) from shapes that have
a concave aspect to part of their peripheries (e.g., blobs that
have one or more inwardly-directed dimples). Much more
sophisticated techniques are commonly used in blob analysis; an
example is a histogram of oriented gradients. (See, e.g., Dalal, et
al, Histograms of Oriented Gradients for Human Detection, IEEE
Conference on Computer Vision and Pattern Recognition, pp. 886-893,
2005.)
[0040] (Commonly, such blob analysis is performed using a support
vector machine method, which classifies shapes based on a set of
reference training data.)
[0041] While luminance was used in the foregoing example, the
technique can also be practiced in a particular color channel, or
in Boolean logical combinations of color channels (e.g., add to the
blob region those pixels whose value in a 500 nm spectral band is
within 3 digital numbers of the seed value, OR whose value in a 530
nm spectral band is within 5 digital numbers of the seed
value).
[0042] Similar methods can be practiced in other domains, such as
using a representation of imagery in the spatial frequency
domain.
[0043] All such image derivatives (metrics) can be computed on
different scales. One scale is across the totality of an image.
Another is to divide the image into hundreds of portions, and
compute the metrics for each such portion. The same image can be
re-divided into tens of thousands of portions, with the metrics
again recomputed. These portions may be of any shape; rectangular
is often computationally efficient, but others can be used. The
portions may be disjoint, tiled, or overlap. If computational
constraints require, the finer scale metrics can be computed on a
subset of all such regions, such as on a random selection of 1% of
100,000 regions.
[0044] As indicated, the image derivatives can be computed on
different color channels. Using methods detailed in the pending
patent application Ser. No. 13/840,451 (now published as
20130308045) and Ser. No. 14/201,852, for example, an image can be
captured and accurately decomposed into five or ten or more
different spectral bands--each of which may have diagnostic
utility. Such spectral-based analysis is not limited to the visible
spectrum; infrared and ultraviolet data is also useful.
[0045] (Ultraviolet light is absorbed by melanin. Thus,
illumination with UV can reveal irregular pigment distribution,
which can aid, e.g., in defining the borders of melanoma.)
[0046] (The CMOS and CCD sensors used in conventional digital
cameras are typically responsive well into the infrared, provided
there is no IR filtering.)
[0047] The image, and image derivatives, can also be based on
polarized light photography.
[0048] Bag-of-features techniques can be applied to the image
derivatives, e.g., as detailed in Csurka, et al, Visual
Categorization with Bags of Keypoints, ECCV, Workshop on
Statistical Learning in Computer Vision, 2004.
[0049] Another image derivative is feature size. Dimensions (e.g.,
diameter) of lesions and other visually-distinguishable skin
features can be assessed from imagery, and this data included with
the derivative image data. (The diagnostic profile of a feature is
often dependent on its size.)
[0050] FIG. 2 is an excerpt of a conceptual view of a reference
database. It includes a variety of records (rows), each comprising
a set of data relating to a reference subject.
[0051] The first column contains an image (or a set of images)
depicting a dermatological condition of the subject. An image can
comprise, e.g., a 10 megabyte color TIF file.
[0052] The second column shows some of the image derivatives
computed from the image. The naming convention gives semantic
information about the type of data, e.g., indicating whether it is
histogram or FFT data, and the coordinate of a tiled sub-region of
the image from which the data was derived.
[0053] The third column shows the location on the subject's body
from which the image was captured.
[0054] The fourth column shows, if available, a diagnosis of the
reference subject's affliction. For some entries, no diagnosis is
provided.
[0055] The fifth column shows additional user metadata. Examples
include demographic information (e.g., age, gender, weight, height,
race, residence location by zip code), and other profile data about
the subject. This can include drugs taken in the past thirty days,
any on-going medical conditions, foods introduced into the
subject's diet in the past thirty days, travel within the past
sixty days, lifestyle activities, environmental exposures, family
medical history, etc.
[0056] It will be seen that information in the fourth and fifth
columns is tagged using XML-style descriptors, to provide for
extensibility and to facilitate text parsing.
[0057] A query image submitted by the user can similarly be
accompanied by the body location and other user metadata
information shown in FIG. 2.
[0058] (Not shown in FIG. 2, but typically present in the knowledge
base for each image, is metadata concerning the image capture
parameters, e.g., in the standard EXIF format.)
[0059] In an illustrative embodiment, a server system determines
similarity scores between a query image and each of many reference
images. One component of such a score can be based on the
reciprocal of a Euclidean distance between an image derivative from
the query image and a corresponding image derivative for a
reference image, in the image derivative feature space. Since each
image may have thousands of derivatives (e.g., based on different
regions and color channels), there can be many thousands of such
components (e.g., comparing a histogram of region 1 of the query
image with histograms of regions 1-1,000 of a reference image, and
likewise for region 2 of the query image, etc.). Typically, such
feature similarity metrics that fall below a statistically
significant threshold are ignored.
[0060] In computing a similarity score for a reference image (i.e.,
relative to a query image), some image derivatives are weighted
more heavily than others. For example, the weight given to a
particular correspondence between a pair of image derivatives can
depend on the scale of the portions between which similarity was
found. The larger the feature, the more weight is typically given
(e.g., in linear or exponential proportion to feature size).
Similarly, some indicia are more diagnostically relevant than
others. Spectral data at 500 nm may be more discriminative than
spectral data at 700 nm, and may be given a commensurately greater
weight, etc. Weightings can be calculated recursively, accounting
for feedback from users of the system about correlations.
[0061] A sampling, or all, of the reference images in the database
are thus scored relative to the query image. In an illustrative
embodiment, the reference images that are scored in the top 5%, or
0.5%, of the universe of evaluated reference images are thereby
identified. Associated user metadata for this set of reference
images is then analyzed.
[0062] Naturally, many of the top matches will be errant. Some of
the information in the database may also be incorrect. In an
information theoretic sense, the data will be very noisy. But in
the aggregate, over a large data set, statistically significant and
useful correlations will be evident.
[0063] For example, analysis of the top-scoring set of reference
images may find that 40% are associated with diagnostic tags
indicating that they depict the condition known as tinea
versicolor, and 23% may be similarly tagged as depicting pityriasis
rosea. 25% of the top-scoring reference images may be associated
with diagnostic tags indicating that the reference subject was
taking the blood pressure medicine Atenolol.
[0064] Of course, a person either has a condition, or doesn't. A
person doesn't suffer from "40% tinea versicolor, 23% pityriasis
rosea, etc." But such a ranked presentation of candidates provides
specific hypotheses that can then be further investigated.
[0065] A statistical breakdown of such correlations is typically
provided to the user--in one or more rank-ordered sets. For
example, the user may be presented with a rank-ordered listing of
the top five or ten possible diagnoses--each including a stated
probability based on frequency of occurrence from the top-matching
reference image set. Similar listings may be presented for
demographic information and other profile data (e.g., drug
correlations, diet correlations, lifestyle correlations, etc.).
[0066] It will be understood that many skin conditions are
themselves symptoms of non-skin disorders. A familiar example is
skin jaundice, which may be associated with liver failure. Such
non-skin diagnoses should also be reflected in the knowledge base,
and in the results reported to the user.
[0067] The absence of apparent correlation can additionally, or
alternatively, be reported to the user. If less than 0.03% of the
reference images in the top-scoring set are associated with tinea
versicolor, whereas this condition has a much greater frequency of
occurrence in the full reference image set (e.g., 1.5%), then the
user can be informed that the skin condition is most likely not
tinea versicolor. Likewise with drugs, diet, lifestyle, etc. (The
particular threshold used in such evaluation can be determined
empirically.)
[0068] The information presented to the user can also include
samples of closely-matching reference imagery--and the diagnosis
(if any) associated with each.
[0069] Another method makes use of changes in the user's depicted
symptoms over time. In such a method, the user submits two images
to the system--an initial one, and a second one taken at a later
time. The system determines data about a change in the depicted
skin symptom between these two times based on the submitted
imagery. This determined data is then used in further refining
diagnostic information.
[0070] Thus, for example, if purpura on the skin enlarge in size
during the course of a disease, this is evidence in favor of
certain candidate diagnoses, and contrary to other candidate
diagnoses. Three or more time-based images can likewise be
used.
[0071] Crowd-sourced data gathering, with subsequent scoring and
statistical calculations as described herein, should both be
initiated as well as managed as it evolves. Expert medical
practitioners have the opportunity to "seed" such databases with
known imagery examples of a variety of afflictions, paying a great
deal of attention to ensuring a wide range of angles, lighting
conditions, parts of the body, camera models, etc. This can involve
the submission of hundreds, thousands or even more images with
clinically derived examples of the major and less major categories
of affliction. Likewise, even as the crowd sourced imagery grows
with time and may soon wind up dwarfing any original "ground truth"
imagery, expert practitioners can still submit known examples of
afflictions into the up-to-date crowd-sourced service as described,
witness the results of the returned information, then proceed to
tune or modify various weighting factors, scoring approaches,
extensions to XML fields, etc., thereby managing the diagnostic
accuracy of the overall service as more and more clients begin to
use the service.
[0072] It will be recognized that certain embodiments of this
technology differ from earlier crowd-sourced dermatological efforts
in various ways. For example, some of the earlier work compiled a
crowd-sourced collection of images that were each accompanied by
professional diagnosis data. The illustrative embodiment has no
such requirement. Similarly, other earlier work employed a "crowd"
to offer plural human assessments of submitted images, from which a
consensus conclusion was derived. The illustrative embodiments do
not require such plural human assessments.
[0073] Unprecedented knowledge will be revealed as the present
system grows to large scale. Error tends towards zero as the
universe of data grows large.
[0074] Data Capture
[0075] The capturing of data from skin can employ known and
forthcoming imaging technologies. A simple one is a smartphone
camera. Accessory optics may be employed to provide better close-up
capabilities. Other digital cameras--including those on headworn
devices--can also be used.
[0076] Exemplary smartphones include the Apple iPhone 5;
smartphones following Google's Android specification (e.g., the
Galaxy S5 phone, manufactured by Samsung, and the Google Moto X
phone, made by Motorola), and Windows 8 mobile phones (e.g., the
Nokia Lumia 1020, which features a 41 megapixel camera).
[0077] Some embodiments employ modular mobile device technology,
such as Google's Project Ara (which derives from the Phonebloks
concept developed by Dave Hakkens; see, e.g., YouTube video
oDAw7vW7H0c and the phonebloks<dot>com web site). In such
arrangements, a mobile device is comprised of detachable
components, which can be added, changed or upgraded as needs
dictate. Through such technologies, a device can be assembled that
includes sensors of the sorts detailed in this disclosure,
especially adapted for physiologic data capture.
[0078] Imagery employed in the present technology may be in JPEG
format, but preferably is in a higher quality form--such as RAW or
TIF.
[0079] The smartphone or other user device can compute some or all
of the derivative information from the sensed data before sending
data to the remote database, or the central system can perform such
calculations, based on provided sensor data. Or these tasks can be
distributed--part performed on one platform, and part on
another.
[0080] In addition to smartphone cameras, image capture can employ
purpose-built hardware. Examples are disclosed in patent
publication 20110301441. Commercial products include the Dermograph
imager by MySkin, Inc., and the Handyscope by FotoFinder Systems.
The latter is an accessory for the Apple iPhone 5 device and
includes built-in illumination--optionally cross-polarized. It is
capable of capturing both contact images (with the device touching
the skin), and non-contact images. A variety of other dermatoscopy
(aka epiluminescence microscopy) hardware systems are known.
[0081] In some arrangements, a physical fixture can be provided on
the imaging device to help establish a consistent imaging distance
to the skin. A rigid black, white or clear plastic cowl, for
example, can extend from the camera lens (and optionally flash) at
one end, to an opening that is placed over the skin, for
controlled-distance imaging.
[0082] Software on the smartphone may employ known auto-focus
technology to set an initial image focus, and can warn the user if
the camera is unable to achieve proper focus. However, some
auto-focus algorithms are easily fooled into focusing on dark hair
that may rise above the skin surface. Accordingly, it is preferable
to capture several still image exposures--one at the nominal
auto-focus setting, and others that are varied under software
control from that position, e.g., at focal planes plus and minus
two and four millimeters from the auto-focus setting. Known
computational photography techniques can combine such images to
yield a composite image with an extended depth of field, as
detailed, e.g., in Jacobs et al, Focal Stack Compositing for Depth
of Field Control, Stanford Computer Graphics Laboratory Technical
Report 2012-1, attached to application 61/872,494. (Other extended
depth of field technologies can also be employed, e.g., as detailed
in U.S. Pat. Nos. 7,218,448, 7,031,054 and 5,748,371.)
[0083] Similarly, the software can employ exposure-bracketing,
since some features may more easily be distinguished in exposures
taken one or two f-stops above, or below, an autoexposure setting.
Known high dynamic range methods can be employed to composite such
images into an enhanced image frame.
[0084] In some arrangements, a camera's frame capture is triggered
based on stability. A stability metric can be based on data from a
smartphone sensor (e.g., an accelerometer). Or it can be based on
analysis of the viewfinder image data. (The Apple iPhone device
includes motion estimation hardware, which is most commonly
employed for MPEG video compression, but which also can track
features in an image frame to assess image stability.)
[0085] While imagery captured by mobile cameras is a focus of this
disclosure, it will be recognized that imagery captured by whole
body scanning systems can likewise be employed. Canfield Scientific
is among the commercial providers of whole body scanners.
[0086] In between smartphones and whole-body scanners are a range
of intermediate imaging systems. One is an automated apparatus that
might be found in a doctor's office or pharmacy, which serves to
capture imagery from a user and submit it to the central system for
analysis, as detailed herein. Such apparatus (which may be, e.g., a
stand-alone kiosk, or integrated into a weight scale in a doctor's
office--capturing frontal face and neck imagery each time a patient
is weighed) can be more sophisticated than that found in most
smartphones, e.g., providing controlled spectral illumination
(e.g., as in application Ser. No. 13/840,451 (now published as
20130308045) and Ser. No. 14/201,852), thermal imaging, etc. It may
provide the user with a hardcopy printout of the results. Such an
apparatus may be available for free use, or a nominal charge may be
collected (e.g., by coin, dollar, or credit card).
[0087] As is familiar to artisans, various photosensitizers (e.g.,
aminolevulinic acid) can be applied to the skin, to highlight
certain tumors, etc., such as by changing their absorbance and
fluorescence spectra.
[0088] In some methods, the user moves a smartphone over a body
area, while the camera captures imagery multiple frames of imagery.
From the different viewpoint perspectives, 3D information about the
skin's surface relief (topology) is discerned, e.g., using familiar
stereoscopy techniques. Google's patent publication 20130201301
details one such arrangement for creating 3D imagery from
smartphone images captured at different viewpoints. Known
Simultaneous Localization and Mapping (SLAM) and Structure from
Motion (SFM) techniques can also be employed--revealing scale as
well as shape. Such a 3D data representation can be virtually
flattened, using cartographic techniques, for analysis and
rendering to the user.
[0089] Patent application Ser. No. 13/842,282, filed Mar. 15, 2013,
details how the sensor in a moving device can be mounted on a
MEMS-actuated pedestal, and moved in a cyclical fashion
synchronized with the frame captures, to counteract motion blur.
The multiple frames of imagery collected in such a capture
arrangement can be combined to yield an enhanced resolution image
(e.g., as is taught in Digimarc's published patent application
20080036886 and in U.S. Pat. Nos. 6,570,613 and 5,767,987).
[0090] Other 3D sensing arrangements are known, e.g., as identified
in copending application Ser. No. 13/750,752, filed Jan. 25, 2013
(now published as 20130223673).
[0091] Above-noted patent application 13/842,282 details a
particularly advantageous 3D camera sensor, employing photosites
that are spectrally tuned--typically providing spectral responses
at many more different wavelengths (e.g., at eight different
wavelengths--some of which may be outside the visible range) than
typical tri-stimulus (red/green/blue color-filter array) sensors of
the previous art.
[0092] Another approach to 3D sensing is via an instrument that is
touched to the skin, causing a membrane to deform in correspondence
with the skin surface texture, forming what may be termed a skin
print. Published patent application 20130033595 details such an
arrangement, including a camera that captures imagery from the back
side of the membrane, under oblique illumination that emphasizes
the texture topography. See also Johnson, et al, Retrographic
Sensing for the Measurement of Surface Texture and Shape, 2009 IEEE
Conf. on Computer Vision and Pattern Recognition (attached to
application 61/872,494). Such apparatus is now available from
GelSight, Inc., of Cambridge, Mass., and may eventually be
integrated into cell phones and other wearable computer
systems.
[0093] Skin topology measured using such skin print techniques is
believed to have a higher sensitivity and specificity for
machine-based identification of certain skin conditions, as
compared with 2D color imagery. Although "ground truth" skin
topographies, which associate particular topographies with
particular expert physician evaluations, are not yet available,
these are expected to be forthcoming, when the utility of such
measurements becomes widely known. Thus, another aspect of the
present technology includes aggregating skin prints for a variety
of medical conditions in a reference database--at least some of
which also include expert diagnoses associated therewith. A related
aspect involves deriving features from such reference prints, and
then using such features in judging statistical similarities
between a query skin print submitted by a user and the reference
skin prints, to identify candidate diagnoses and other correlated
information--as described earlier.
[0094] Skin surface minutiae can also be sensed otherwise, such as
by systems for capturing human fingerprints. Examples are known
from the published patent applications of AuthenTec (subsequently
acquired by Apple), including applications 20120085822 and
20110309482. Such sensors are already included in many laptop
computers, and will doubtless soon appear in smartphones and the
like.
[0095] Another image data collection technique comprises a flexible
sheet with organic transistor circuits. The circuits can comprise
photodetectors, as detailed, e.g., in Fuketa, et al, Large-Area and
Flexible Sensors with Organic Transistors, 5th IEEE Int'l Workshop
on Advances in Sensors and Interfaces, 2013, and Baeg et al,
Organic Light Detectors-Photodiodes and Phototransistors Advanced
Materials, Volume 25, Issue 31, Aug. 21, 2013, pp. 4267-4295, (both
attached to application 61/872,494), and in references cited
therein. Such media can also include integrated OLED
photodetectors--providing controlled illumination.
[0096] As earlier noted, polarized light photography can also be
useful with the present technology. This can be implemented with
polarized illumination, or with one or more polarizers on the
camera or image sensor. (See, e.g., Gruev, et al, CCD Polarization
Imaging Sensor with Aluminum Nanowire Optical Filters, Optics
Express 18.18 (2010): 19087-19094, which details a sensor having a
polarizing filter associated with each pixel. The filters have four
different orientations, offset by 45 degrees. By reading data from
differently-filtered sets of pixels, different image polarizations
are sensed.) By sensing imagery at different polarizations,
different image features can be revealed and different image
effects can be achieved (e.g., increased contrast). Some research
also indicates that polarized light, when reflected, has two
orthogonal components--one due to the skin surface morphology, and
the other "back-scattered" from within the tissue.
[0097] While a user of the detailed system can submit a single
image for analysis, it is sometimes preferable to submit several.
As noted, these may comprise differently-focused, or
differently-exposed images. They can also comprise lesion-centered
images from different viewing distances, e.g., a close-up (e.g.,
where the lesion spans 25% or more of the image width), a mid-view
(e.g., where the lesion spans between 5 and 25% of the image
width), and a remote view (e.g., where the lesion spans less than
5% of the image width).
[0098] The remote view will typically show a sufficiently large
body excerpt that the location of the lesion (e.g., arm, foot,
hand, face) can be determined using known anatomical classification
techniques. (Many smartphone operating systems, including those
from Apple, include facial recognition capabilities--which begin by
recognizing a face in an image.) Such lesion location data can then
automatically be entered into the knowledge base, without requiring
entry of such information by the user. (In other embodiments,
software can present the user with a 3D avatar on which the user
virtually draws, or taps, to indicate locations of skin lesions.)
Seeing the lesion in the context of an identifiable body part also
provides context from which the size of the lesion can be
estimated. E.g., the average man's palm is 3.05 inches across,
permitting the size of a lesion depicted in the same frame to be
deduced.
[0099] As cameras and sensors continue to evolve, all three such
views may be captured from a single camera position. For example, a
telephoto lens may progressively zoom-out to capture the three
just-referenced views. Or a high resolution sensor may have
sufficient resolution that the former two views can be extracted
from a remote view image frame. The software application may
automatically obtain the three images--controlling the zoom or
cropping a high resolution image as appropriate. (Desirably, each
view is at least 1000 pixels in width.)
[0100] In some embodiments, the smartphone software offers guidance
to the user in capturing the images, e.g., directing that the user
move the camera away from the body until the software's body part
classifier is able to identify the body part in the third view.
Other direction, e.g., concerning lighting and focus, can also be
provided.
[0101] It is also sometimes diagnostically useful to consider
images from different parts of the body. If a lesion appears on a
user's forearm, a second image may be submitted depicting the
user's other forearm, or a skin patch that is not normally exposed
to the sun--such as under the upper arm. Difference metrics can
then be computed that compare the skin parameters around the lesion
site with those from the other site. These data, too, can be
submitted to the knowledge base, where similarities with other
reference data may become evident.
[0102] Additional sensors will soon be commonplace on personal
devices. Already appearing, for example, are smartphones equipped
with multiple microphones. As further detailed below, in
conjunction with a smartphone speaker, such a device is tantamount
to an ultrasonic imager. Such a device can be pressed to the user's
skin, and the skin them stimulated by ultrasonic sounds emitted by
the speaker (or by other transducer--such as a piezo-electric
actuator). The microphones--sensing reflection of such acoustic
waves from inside the body, to the different microphone
locations--provide information from which imagery can be
constructed. Such ultrasonic imagery is more grist for the present
mill.
[0103] Similarly, liquid lenses (e.g., marketed by Philips under
the FluidFocus brand) may soon appear on smartphones, and enable
new camera close-up and topological sensing capabilities.
[0104] In contact-based imaging (i.e., with the imaging apparatus
touching the skin), the body location from which the image is
captured can be electrically sensed using small amplitude
electrical waveforms inserted in the body by a wearable computer
device--such as the Google Glass device, or a wrist-worn device.
Especially if different signals are introduced into the body at two
locations, their distinctive superposition at the sensing site can
accurately pinpoint the location of such site.
Ambient Light, Pose, Scale, etc.
[0105] Color is an important diagnostic feature in assessing
dermatological conditions. However, skin color, as depicted in
captured imagery, strongly depends on the "color" of the light that
illuminates the skin. While dermatologists can control illumination
conditions in their offices, most consumer image capture is
performed under widely varying lighting conditions. To optimize
performance of the detailed technologies, this variability should
be mitigated.
[0106] Digital cameras commonly perform automatic white balance
(AWB) adjustment. Various techniques are used. One technique
examines the pixels in an image, and identifies one that is the
brightest. This pixel is assumed to correspond to a white or shiny
feature in the image, i.e., a feature that reflects all of the
incident light, without absorbing any particular color. The
component color values of this pixel are then adjusted to make it
truly white (e.g., adjusting an RGB representation to
{255,255,255}), and all other pixels in the image are remapped by
similar proportions. Another technique averages all of the pixels
in the image, and assumes the average should be a shade of grey
(e.g., with equal red, green, and blue components--if represented
in the RGB color space). A corresponding adjustment is made to all
the image pixels, so that the average is remapped to a true shade
of grey.
[0107] The former technique is ill-suited for skin photography
because there is typically no white or specular pixel in the image.
The latter technique is ill-suited because its premise--that the
average pixel value is grey--is not true for skin images.
[0108] Professional portrait photographers sometimes position a
calibration card at the edge of a family group, where it can be
cropped-out before printing. The card includes various reference
colors, including white and other known tones. Before printing,
digital adjustments are made to the image to bring the depiction of
colors on the calibration card to their original hues--thereby also
color-compensating the portrait subject.
[0109] Thus one approach to the ambient light issue is for a user
to capture imagery from a calibration card, and send this image to
the central system, accompanying the skin image(s). The system can
then color-compensate the skin image(s), based on the depiction of
colors in the calibration card image.
[0110] However, such calibration cards are not readily available,
and cannot typically be electronically distributed to users for
printing, due to color variability among consumer printers.
[0111] Applicant has found that various other materials can suffice
in lieu of calibration cards.
[0112] One is a white envelope. The "white" on color calibration
cards is a colorimetrically true white, whereas there is a great
deal of variability in what passes for white among the lay public.
But applicant has found that white postal mail envelopes tend to be
consistent in their color--especially at the red end of the
spectrum that is important for skin photography (there is more
item-to-item variability at the violet end of the range). While not
"true white" in a colorimetric sense, such envelopes are generally
consistent enough to serve as a color reference.
[0113] So one approach to ambient light issues in consumer skin
photography is to direct the user to capture imagery from a white
envelope, under the same lighting conditions as the skin
photograph(s). This image can be sent to the central system, where
the skin photograph can be color-corrected based on the envelope
photograph.
[0114] The entire envelope needn't be photographed--just a fraction
will do. In one method, a part of the envelope substrate is torn or
cut off, and placed on the skin, within the camera's field of view.
But such arrangement a single image capture can suffice. Meanwhile,
at the central system, the illumination-corrected, reflected color
spectra from an assortment of white postal envelopes are captured
and averaged, and used as reference data against which images
received from end users are color-corrected.
[0115] (It will be recognized that placing a piece of a white
envelope in the field of view of a skin photograph can allow
automatic white balance correction of the image by the camera--if
the camera is using the former of the above-described two AWB
techniques. However, the details of a particular camera's AWB
algorithm are not generally known. The central service may,
however, investigate the AWB techniques used by popular smartphone
cameras. By examining the metadata that commonly is packaged with
smartphone imagery, e.g., in the form of EXIF header data in an
image file, the central system can determine the type of camera
with which a user image was captured. If the image was captured
from one of the cameras using the former AWB technique, and
automated image analysis finds that the image includes an area of
white next to skin tone, the system can infer that appropriate
color correction has already been applied by the camera.)
[0116] Another commonly available color reference--for those
so-inclined--is oxygenated blood. Blood exhibits a consistent color
spectrum despite race and other variable factors. If a drop of
blood is thick enough to mask the underlying skin pigment, its
color can be sensed and again used to reveal color information
about the illumination.
[0117] Color calibration can also be performed with banknotes.
Banknotes are typically printed with extremely high tolerances, and
consistent ink colors. Desirably, a banknote excerpt having colors
near the skin tone range is employed. While US currency is commonly
regarded as green, in fact the US $20 bill has areas of skin-like
tones to the left and right of the Jackson portrait. (The US $10
has areas of reddish tones.)
[0118] In accordance with this method, the user captures images of
the skin, and of a US $20 banknote, under the same illumination
conditions. Both the skin image and the banknote image are then
sent to the central system. The central system again compares the
spectrum found in the received banknote image with reference data,
and determines a spectral correction function detailing variance
between the received banknote image and reference data. The system
then applies this correction function to the received skin image,
to effect color correction.
[0119] Since color correction is primarily needed for skin tones,
areas of a banknote lacking such colors can be omitted in
performing the spectrum measurement and correction. The central
system can virtually identify the relevant areas of the banknote
artwork by reference to image features--such as SURF or SIFT
keypoints, or by other pattern-matching techniques. An area bounded
by such points can be virtually "clipped" from the artwork, and
used as the basis for comparison against a similarly-clipped set of
reference data. FIGS. 3A and 3B show the banknote artwork, and a
representative clipped region spanning most of the skin tone
region. This area is defined by "corner" features in the original
artwork (e.g., the upper right corner of the letter E in " . . .
PUBLIC AND PRIVATE;" the lower left corner of the A in AMERICA;
etc.), and omits artwork that can vary between banknotes, i.e., the
serial number.
[0120] The reference data is acquired by a reflectance spectroscopy
technique that involves masking the banknote with a flat black
mask--revealing only the clipped region--and illuminating with a
light source whose spectrum is measured or otherwise known.
Reflected light is sensed by a spectrometer, yielding a set of data
indicating intensity as a function of wavelength. This measured
data is then adjusted to compensate for the known spectrum of the
light source.
[0121] FIG. 4 shows such a reference spectrum measured for both the
Jackson portrait excerpt shown in FIG. 3B (the lower line), and for
a sample white postal envelope.
[0122] The contemplated system may serve users in diverse
countries. Desirably, suitable calibration objects are identified
so that one or more is available in each of these countries. The
central system can examine the incoming imagery, and compare
against a catalog of calibration objects to recognize which object
is being used. Thus, a customer may choose to use a Mexican 100
peso note as a reference, and the central system will recognize
same and apply the corresponding correction function.
[0123] It will be recognized that the above-described procedures
for effecting correction of colors due to ambient lighting
variability also effect correction of colors due to camera sensor
variability. That is, if one camera tends to emphasize greens, and
another camera tends to emphasize reds, the imagery from both will
be normalized to a consistent standard using the arrangements
detailed above.
[0124] The procedure employing a printed object in the image frame
with the skin (as opposed to a white object) also allows the system
to assess the brightness of the imaged scene. Cameras have limited
dynamic range. If a scene is too brightly lit, the camera's
component red, blue and green sensors can no longer sense
variability between different parts of the image. Instead, each
outputs its full maximum signal (e.g., 255, in an 8-bit sensor).
Faithful color sensing is lost. Similarly with too little
illumination; differently-colored areas are again
indistinguishable. By imaging a known printed object, such as a
banknote, such over- and under-exposure can be sensed (by
comparison of detail in the sensed imagery with detail in reference
imagery), and the user can be prompted to change the illumination
and submit a new image, if needed.
[0125] If a known printed object is used as a color reference
object, the object artwork also enables other information to be
sleuthed, such as scale, provided the object is depicted in the
same image frame as the skin condition. To illustrate, the distance
between the centers of Jackson's eyes on the US $20 banknote is 9
mm. If such a banknote is photographed next to a lesion, and the
distance between Jackson's eyes spans 225 pixels, and the lesion
spans 400 pixels, then the lesion is known to have a width of 16
mm. Dimensions of other features in the image can be similarly
determined.
[0126] If the printed object lies in the same plane as the skin,
then the pose of the camera relative to the skin can also be
determined--based on apparent geometrical distortion of the object.
That is, if the camera axis is not perpendicular to the skin, then
perspective distortion will cause features depicted in some parts
of the frame to be larger, or smaller, than would be the case with
a perpendicular pose. By reference to the known aspect ratio of
features on the printed object, and comparison with their aspect
ratio in the captured imagery, the angle from which the image was
captured can be sleuthed, and a corrective counter-distortion can
be applied. (The camera's optic function can also be considered in
the analysis, to account for the expected apparent distortion of
features displaced from the center of the image frame. For example,
the circular seal of the US Federal Reserve System, on the left
side of a banknote, may be subtly distorted from round--even with a
perpendicular camera pose--if the seal is not at the center of the
image. Such distortion is expected, and the analysis takes such
normal artifacts of perpendicular poses into account.)
[0127] In the case of banknotes, still finer pose determinations
can be made, based on security features that have different
appearances with different viewing angles. Color-shifting inks,
security threads with microscopic lenses, and kinegrams, are of
this sort. The central system can collect reference information
quantifying the appearance of these features at different viewing
angles. When a user-submitted image is recognized to have such a
banknote security feature depicted, its rendering in the image can
be matched with the reference information to determine the angle at
which it is being viewed--from which the viewing angle of the skin
lesion can then be determined. (In many such measurements, the
color of the security feature shifts with viewing angle. Thus, it
is desirable to first perform color-correction on the
user-submitted imagery, before analyzing pose in this fashion.)
[0128] Another calibration token that can be placed on the skin for
image capture is a coin. Again, a variety of different coins may be
recognized by the central system--and from their known attributes,
scale and pose determinations can be made--just as with the
banknote arrangement described above. Also, many coins exhibit the
specular reflection used by many cameras for automatic white
balance.
[0129] Other commonly available items that can be placed in the
image frame to serve as props for color correction and/or scale
measurement include the white cord of Apple USB cables and earbuds,
and the USB plug itself. The user's thumb (or other finger) can
also be put into the image frame--providing a scale reference and
also skin tone information.
[0130] Another approach to dealing with ambient light variability
is to employ the smartphone's front-facing camera.
[0131] Smartphones are commonly equipped with two cameras--one on
the front, facing the user, and one on the rear. The latter is
typically used for capturing skin imagery. But the former can be
used to capture image data from which ambient lighting can be
assessed. The field of view of the front-facing camera can include
a variety of subjects--making its automatic white balance
determination more trustworthy than the rear-facing camera (whose
field of view may be filled with skin).
[0132] In accordance with this aspect of the technology, an
automatic white balance assessment is made using the front-facing
camera, and resulting information is then used in AWB-processing of
skin imagery captured by the rear-facing camera.
[0133] Still another approach to dealing with ambient light
variability is to use flash illumination. The light emitting diodes
(LEDs) used for camera flashes have relatively consistent spectra
among instances of a particular model (e.g., iPhone 5 cameras).
Reference data about flash spectra for popular camera models can be
compiled at the central system. Users are then instructed to
capture the skin image in low ambient light conditions, with the
camera flash activated. When the central system receives such
imagery, it examines the header data to determine the camera model
involved, and flash usage. The system then applies a color
correction that corresponds to the flash spectrum for that model of
camera.
[0134] Low ambient light can sometimes be difficult to achieve. And
adapting technical methods to the user, rather than adapting user
actions to the technology, is generally preferable. In accordance
with another aspect of the technology, flash is used in conjunction
with ambient lighting for color correction.
[0135] In one such method, two images are taken in quick
succession--one including an LED flash, and one not. (Video mode
can be used, but resolution is typically better in a still image
capture mode.) Both images include the ambient light, but only one
includes the flash. Subtracting the two images leaves a difference
image that is illuminated by the LED flash alone-mitigating the
uncertainty due to unknown ambient lighting. (The images can be
spatially registered prior to subtraction, using known registration
techniques, to account for slight motion between frames.) Again,
the resulting image can be adjusted to compensate for the spectrum
of the LED flash. Software on the user device can effect such image
capture, flash control, and differencing operation.
[0136] Still another technique for color compensation is by
reference to measured norms of skin coloration. While skin comes in
a variety of colors, these colors comprise a tiny fraction of the
universe of possible colors. This is particularly true when skin
color is represented in the CIELAB color space. This range is
narrowed still further if the user's race is known, e.g., entered
via the user interface of a smartphone app, or recalled from stored
user profile data.
[0137] (In smartphones equipped with front- and rear-facing
cameras, the former can be used to capture a picture of the
user--since the user typically operates the phone facing towards
the screen. Known techniques can assess the user's race (and
gender) from facial imagery--avoiding the need for the user to
enter this information. See, e.g., Lyons, et al, Automatic
Classification of Single Facial Images, IEEE Trans. on Pattern
Analysis and Machine Intelligence, Vol. 21, No. 12, 1999, pp.
1357-1362 (attached to application 61/872,494), and references
cited therein. The race assessment can be performed by smartphone
app software, so that the user's facial image is not sent from the
phone.)
[0138] Since the user will typically frame a captured image so that
a skin condition of concern is at the center, a better indication
of the user's normal skin color may be obtained by sampling away
from the center, e.g., at the edges. An average color, based on
samples taken from a variety of peripheral image locations, can be
computed. (Samples should be checked to assure that a location does
not correspond to clothing or other non-skin feature. Color
consistency and/or segmentation techniques can be used.) This
baseline skin color can then be checked against statistical color
norms--for the user's race, if known. If this baseline color is
outside of the statistical norm (e.g., within which 99%, or 99.9%
of the population falls), then an adjustment is made to the
captured imagery to shift the image colors so that the average
falls within the norm. (The shift can move the average skin tone to
the nearest edge of the norm region--as defined in the CIELAB color
space--or to the center of the norm region.) For more on norms of
skin colors, and related information, see, e.g., Zeng, et al,
Colour and Tolerance of Preferred Skin Colours, Color and Imaging
Conference, Society for Imaging Science and Technology, 2010
(attached to application 61/872,494), and references cited
therein.
[0139] While reference was made to assessing the size of skin
features by reference to another article (e.g., a coin) in the
image frame, other techniques can also be used.
[0140] One is by photogrammetry, using camera and image data. For
example, if the image metadata indicates the camera autofocus
(subject distance) was set at 6 inches, and the camera is known to
capture a field of view that is four inches wide in that focal
plane, then an image feature that spans a tenth of the width of the
frame has a width of 0.4 inches. (Instead of autofocus information,
data from a smartphone's proximity detector can alternatively be
used. Such detectors primarily rely on capacitive techniques and
are presently of short range, e.g., 2 cm., but longer range sensors
are under development.)
[0141] An allied technique, also from the field of photogrammetry,
is bundle adjustment. (See, for example, Triggs et al, Bundle
Adjustment--A Modern Synthesis, Proceedings of the International
Workshop on Vision Algorithms. Springer-Verlag., pp. 298-372,
1999). In bundle adjustment algorithms, multiple images taken from
different locations and/or directions are exploited to jointly
produce estimates of the optical view parameters of the camera(s)
and a 2D or 3D model of the scenes imaged. While bundle adjustment
originated in the photogrammetry community, it has found much
recent use in the computer science field, where is a fundamental
component of shape from motion algorithms. Partial knowledge of the
characteristics of the camera(s) can be used to improve the
accuracy of the scene model. In the case of skin images captured
with a smartphone, the multiple images may be made by passing the
camera over the patch of skin. By exploiting the redundancy
provided by images taken from different perspectives, it is
possible to provide scale to the images. Since smartphones
typically also have IMUs and/or gyroscopes, it is possible to
improve upon the performance of these algorithms by feeding in this
sensor information as side information.
[0142] Another scaling technique relies on known biometric norms.
For example, in adults, the inter pupillary distance (the distance
from the center of one eye pupil to the center of the other) is
about 62 mm. A variety of other consistent biometric measurements
are known (going back to the carpenter's "Rule of Thumb" of
antiquity), or can be gathered from analysis of data. Some are
absolute measures (e.g., the inter pupillary distance is about 62
mm), and others are ratios (e.g., the ratio of forearm length, to
forearm plus hand length, is about 0.58). Some such measures are
tightly clustered, based on the user's gender and height. Image
classification techniques can be applied to user imagery to
recognize pupils, a thumb, a fingernail, a forearm, a hand, etc.
From known biometric measures, the size of a skin lesion can be
inferred.
[0143] Other scaling techniques rely on such biometric norms, in
conjunction with imagery from front- and rear-facing cameras.
Consider a user taking a picture of a lesion on their forearm. The
forearm can be recognized from imagery captured by the smartphone
camera. The smartphone is positioned somewhere between the user's
face and forearm, but its distance from the arm is unknown
(disregarding auto-focus and other estimation techniques). However,
previous experimentation shows that a typical user tends to hold
their smartphone camera about 12 inches from their face, when
viewing their forearm.
[0144] The front-facing camera can capture an image of the user's
face. While the distance from the phone to the forearm is unknown,
the distance from the phone to the face can be deduced from the
pixel sizing of the inter pupillary distance. (The closer the phone
is to the face, the larger the distance between the user's pupils
becomes--in terms of pixel spacing.) Based on previous
experimentation, or based on analysis of the camera's optics, the
pixel spacing between the depicted pupils directly correlates to
the distance between the front-facing camera and the user's face.
Subtracting this value from 12 inches yields the viewing distance
between the smartphone and the user's forearm. From this viewing
distance, and information about the camera's optics, the size of
features on the skin can be deduced.
[0145] Similarly, the color of facial skin depicted in imagery
captured by the front-facing camera, can be used in assessing the
color of skin depicted in imagery captured by the rear-facing
camera. In one scenario, the facial skin may be used as a reference
skin color. (Facial recognition techniques can be applied to
identify the eyes and nose, and from such information the portion
of the imagery depicting cheeks and forehead can be determined.
Skin facial color can be sampled from these locations.)
[0146] Relatedly, eye color is a useful tool in establishing an
expected skin color. For example, a grey iris is most commonly
associated with people of Northern and Eastern European descent,
for whom norms of skin coloration can be established. Ethnic
associations with other eye colors are also well known. (See, e.g.,
the Wikipedia article "Eye color.")
[0147] If imagery of the subject skin condition--captured by the
rear-facing camera--exhibits a skin color that is different than
this reference color, such difference may be taken as a diagnostic
indicia. Likewise the reference facial skin color can be used in
segmenting features from the skin imagery captured by the
rear-facing camera.
[0148] In some instances, the skin imaged by the rear-facing camera
(e.g., on the user's forearm) may be illuminated differently than
the facial skin imaged by the front-facing camera. For example, the
user may have oriented a fluorescent desk lamp towards their arm to
provide more light. As noted, such lighting changes the apparent
color of the skin. Relatedly, the skin imaged by the rear-facing
camera may be within a shadow cast by the phone. By comparing the
skin colors imaged by the front- and rear-facing cameras, such
illumination issues can be detected (e.g., by difference in
chrominance or luminance), and corrective compensations then
applied.
Longitudinal Studies
[0149] As noted, the evolution of a skin condition over time can be
useful in its assessment. Images of a skin condition taken at
different times can be shown in different manners to illustrate
evolution of the condition.
[0150] Desirably, the images are scaled and spatially aligned
(i.e., registered), so that a consistently-sized and oriented frame
of reference characterizes all of the images. This allows growth or
other change of a lesion to be evident in the context of a
generally unchanging background.
[0151] Images can be scaled and aligned using known techniques.
Exemplary is by reference to SIFT or SURF features, in which robust
feature key points that are common throughout images are
identified, and the images are then warped (e.g., by an affine
transform) and rotated so that these points become located at the
same positions in each of the image frames. (One such arrangement
is detailed in applicant's patent application 20120208592.)
[0152] To facilitate this operation, it is desirable (although not
essential) to first identify the extent of the lesion in each of
the frames. Known boundary-finding algorithms can be applied to
this task (sometimes predicated on the assumption that the lesion
of interest is found in the center of the image frame). Once the
boundary of the lesion in each image is identified, the lesion can
be masked (or flooded with a uniform color) so that the key point
identification method does not identify key points from the lesion
or its boundary. This reduces the key point count, and simplifies
the later matching of common keypoints between the images.
[0153] Body hair can also be a source of many superfluous key
points in the different image frames--key points that typically
don't help, and may confound, the image registration process. Thus,
the images are desirably processed to remove hair before key points
are determined. (There are a variety of image processing algorithms
that can be applied for this task. See, e.g., Abbas, et al, Hair
Removal Methods: a Comparative Study for Dermoscopy Images,
Biomedical Signal Processing and Control 6.4, 2011, pp. 395-404
(attached to application 61/872,494), and references cited
therein.)
[0154] Key points are then extracted from the imagery. Depending on
the magnification of the images, these points may be associated
with nevi, hair follicles, wrinkles, pores, pigmentation, textures,
etc. If the imaging spectrum extends beyond the visible, then
features from below the outermost layer of skin may be evident, and
may also serve as key points.
[0155] A key point matching search is next conducted to identify
corresponding key points in the images.
[0156] One image is next selected as a reference. This may be,
e.g., the most recent image. Using the extracted key point data,
the rotation and warping required to transform each of the other
images to properly register with the reference image is determined.
These images are then transformed in accordance with such
parameters so that their key points spatially align with
corresponding key points in the reference image. A set of
transformed images results, i.e., the original reference image, and
the rotated/warped counterparts to the other images.
[0157] (If the lesion were on a flat, rigid surface, then each skin
image would be related to the others by a simple rotation and
affine transform. This is generally a useful approximation for all
cases. However, due to the curvature of some skin surfaces, and the
fact that skin may stretch, a more generalized transform may be
employed to allow for such variations.)
[0158] One form by which the transformed images can be presented is
as a stop-action movie. The images are ordered by date, and
rendered sequentially. Date metadata for each image may be visibly
rendered in a corner of the image, so that the date progression is
evident. The sequence may progress automatically, under software
control, or each image may be presented until user input (e.g., a
tap on the screen) triggers the presentation to advance to the next
image.
[0159] In some automated renderings, the software displays an image
for an interval of time proportionate to the date-span until the
next image. For example, if images #1-4 were captured on successive
Mondays, and then two Mondays were missed before images #5-8 were
captured (again on successive Mondays), then images #1-3 may be
presented for one second each, and image #4 may be presented for
three seconds, followed by images #5-7 presented for one second
each. (Image #8--the last image--may remain on the screen until the
user takes a further action.) A user interface control can be
operated by the user to set the speed of rendering (e.g., the
shortest interval that any image is displayed--such as one second
in the foregoing example, or the total time interval over which the
rendering should occur, etc.).
[0160] A different form by which the transformed image set may be
viewed is as a transitioned presentation. In this arrangement, a
video effects transition is employed to show information from two
or more image frames simultaneously on the display screen. In a
simple arrangement, image #1 (the oldest image) is displayed. After
an interval, image #2 begins to appear--first as a faint ghosting
effect (i.e., a low contrast overlay on image #1), and gradually
becoming more definite (i.e., increasing contrast) until it is
presented at full contrast. After a further interval, image #3
starts to appear in like fashion. Optionally, the older images can
fade out of view (e.g., by diminishing contrast) as newer images
ghost-into view. At different times there may be data from one,
two, or more images displayed simultaneously. As before, the
progression can be under software, or user, control.
[0161] In the above examples, the renderings may employ the images
from which hair was digitally removed (from which key points were
extracted). Alternatively, the renderings may employ the images
with hair undisturbed.
[0162] In some arrangements, the rendering sequences can be
accompanied by measurement data. For example, a textual or
graphical overlay added to a corner of the presentation may
indicate the width or area of the depicted lesion, e.g., an area of
12 mm.sup.2 in the first image, 15 mm.sup.2 in the second image, 21
mm.sup.2 in the third image, etc. Similarly, for each frame, the
color or darkness of the lesion, or its boundary irregularity or
its texture, may be quantified and expressed to the user.
[0163] In still other arrangements, such information is not
presented with each image in the series. Rather, at the end of the
rendering, information is presented detailing a change in the
lesion from the first frame to the last (e.g., the lesion has
increased in area by 83% in 7 weeks).
[0164] Such statistics about the lesion, and its changes, can also
be presented as a textual or graphical (e.g., with Cartesian
graphs) report, e.g., for emailing to the user's physician.
[0165] It will be recognized that the skin features from which the
key points are extracted define a characteristic constellation of
features, which permits this region of skin to be distinguished
from others--a fingerprint of the skin region, so to speak--and by
extension, a fingerprint of the user. Thus, even if a skin image is
submitted to the central server data identifying the user, this
characteristic fingerprint information allows the system to
associate the image with the correct user. This may be used as a
privacy-preserving feature, once a characteristic constellation of
skin features has been initially associated with a user. (This
distinctive constellation of features can also serve as a biometric
by which a person can be identified--less subject to spoofing than
traditional biometrics, such as friction ridges on fingertips and
iris pattern.)
[0166] It will further be recognized that features surrounding an
area of interest on the skin effectively serve as a network of
anchor points by which other imagery can be scaled and oriented,
and overlaid, in real time. This permits an augmented reality-type
functionality, in which a user views their skin with a smartphone,
and a previous image of the skin is overlaid in registered
alignment (e.g., ghosted), as an augmentation. (A user interface
control allows the user to select a desired previous image from a
collection of such images, which may be stored on the user device
or elsewhere.) As the user moves the phone towards or away from the
skin--changing the size of the lesion depicted on the camera
screen, the size of the overlaid augmentation similarly
changes.
[0167] As the size of the knowledge base increases, so does its
utility. At a sufficiently large scale, the knowledge base should
enable detection of pathologies before they become evident or
symptomatic. For example, a subtle change in skin condition may
portend a mole's shift to melanoma. Development of a non-uniformity
in the network of dermal capillaries may be a precursor to a
cancerous growth. Signals revealed in skin imagery, which are too
small to attract human attention, may be recognized--using machine
analysis techniques--to be warning signals for soon-to-be emergent
conditions. As imaging techniques advance, they provide more--and
more useful--weak signals. As the knowledge base grows in size, the
meanings of these weak signals become clearer.
[0168] To leverage the longitudinal information in the knowledge
base, image information depicting a particular user's condition
over time must be identifiable from the data structure. As
described above, the unique constellation of features associated
with a particular region of skin on a user, allows all images
depicting this patch of skin on this user to be associated
together--even if not expressly so-identified when originally
submitted. The FIG. 2 data structure can be augmented by a further
column (field) containing a unique identifier (UID) for each such
patch of skin. All records in the data structure containing
information about that patch are annotated by the same UID in this
further column. (The UID may be arbitrary, or it may be derived
based on one or more elements of user-related information, such as
a hash of one of the user's image file names, or based on the
unique constellation of skin feature points.)
[0169] As data processing resources permit, the central system can
analyze the longitudinal information to discern features (e.g.,
image derivatives) that correlate with later emergence of different
conditions. For example, if the system finds a hundred users
diagnosed with melanoma for whom--in earlier imagery--a network of
capillaries developed under a mole that later become cancerous, and
this network of capillaries is denser, by a factor of two- to
three-times, than the density of capillaries in surrounding skin,
then such correlation can be a meaningful signal. If a new user's
imagery shows a similar density of capillaries developing under a
mole, that user can be alerted to historical correlation of such
capillary development with later emergence of melanoma. Such early
warning can be key to successful treatment.
[0170] In the example just-given, the correlation is between a
single signal (dense capillary development) and a cancerous
consequence. Also important are combinations of signals (e.g.,
dense capillary development, coupled with die-off of hair in the
mole region). Known data mining techniques (including supervised
machine learning methods) can analyze the knowledge base
information to discover such foretelling signals.
[0171] Naturally, information discovered through such analysis of
knowledge base information is, itself, added to the knowledge base
for future use. As new correlations are discovered, new insight
into previously-submitted imagery may arise. The central system can
issue email or other alerts to previous users, advising them of
information that subsequent data and/or analysis has revealed.
[0172] While the foregoing discussion concerned studies of a single
skin site, it was earlier noted that information about skin
conditions at other places on the body may also be relevant. Thus,
in conducting such longitudinal studies, consideration may also be
given to information in the knowledge base, and in the user data,
concerning other skin sites. (Such other skin site information may
be considered as another element of user metadata, noted earlier,
all of which should be employed in discovering patterns of
correlation.)
[0173] Application of machine learning technologies for cancer
prediction is a growing field of endeavor. See, e.g., Cruz, et al,
Applications of Machine Learning in Cancer Prediction and
Prognosis, Cancer Infom., No. 2, 2006, pp. 59-77; Bellazzi, et al,
Predictive Data Mining in Clinical Medicine--Current Issues and
Guidelines, Int'l J. of Medical Informatics, V. 77, 2008, pp.
81-97; and Vellido, et al, Neural Networks and Other Machine
Learning Methods in Cancer Research, in Computational and Ambient
Intelligence, Springer, 2007, pp. 964-971 (attached to application
61/872,494), and references cited therein.
Image Registration Using Multi-Spectral and Hyper-Spectral
Imagery
[0174] The previous discussion, outlining approaches for
registering images in longitudinal studies, can benefit further
when those images might contain more than just the standard RGB
layers of a color image. The reason for this is that skin texture,
hair, lesion boundaries--and a much longer list of skin attributes
than just these--all can be enhanced in their discrimination and
contrast by their representations as higher dimensional data
structures. Many of the practical challenges encountered in trying
to perform these registration techniques on standard color
imagery--such as feature point fading between one day where a patch
of skin is drier and giving rise to distinct line features and the
next day where a person has applied skin moisturizers and has
effectively removed those lines--can be overcome through the
seeking and measurement of higher dimensional image features. The
detailed warping arrangements whereby stretched skin in one image
must be re-stretched to match another image also can make use of
such higher dimensional hyper-spectral features.
Image Registration Through Motion
[0175] Another way to enhance skin-patch and/or lesion registration
is through teaching users of such an app to use and perfect the
motion of their camera itself while gathering imagery of their
skin. The resultant motion of the skin regions manifested in the
imagery itself, often combined with the on-camera motion
information data common to almost all smartphones, allows for
further degrees of information to be utilized in precise millimeter
and sub-millimeter scale matching of some given skin sample and the
imagery of the same skin taken weeks, months or even years earlier.
Many detailed features change often drastically over such lengthy
time periods, where the use of motion imagery and the resultant
parallax data information can help to derive additional shape and
perspective information, all of which assists in the generic task
of stabilizing the viewing and interpretability of often quite
dynamic skin conditions and lesions.
Finger-Slide Viewing of Time Sequences
[0176] As is familiar in certain smartphone user interfaces,
another method of viewing skin conditions over time is to finger
slide back and forth in time through the registered imagery. This
doesn't need to be limited to the viewing of pathological
conditions either; it can be as simple as the desire of a teenager
to simply view how their make-up appearance has changed over the
last few weeks, or a review of what color of eye-liner they might
have utilized two weeks earlier. In such non-ailment applications
of this technology, further user interface choices can be presented
to a user once they have honed in on some particular earlier
imagery, such as displays of the very particular brands and types
of commercial products may have an association with a particular
earlier date. Likewise, back in a pathological context, a user may
be trying various treatments for acne for example, and they will
want to be able to finger scroll between images taken when they
were trying brand X, and images when they we trying brand Y.
Managing Cultural Tensions Inherent in Automated Screening and
Computer Assisted Diagnosis (CAD)
[0177] Those familiar with the early 21st century growth in the use
of computers in helping to detect and diagnose disease are equally
familiar with the large divisions in the cultural acceptance of
this inevitable trend. It is difficult to disagree with the
statement, "both sides are right." If we caricaturize one camp as
the proponents who correctly claim that computers can expand health
care well beyond the wealthier classes and countries, and the other
camp as not necessarily opponents but critics who correctly claim
that poorly executed health services often violate the Hippocratic
oath, then we find ourselves in a stalemate that only time and the
market will slowly break up.
[0178] This disclosure presents humble yet explicit technological
components meant to directly address these tensions as opposed to
trying to ignore them and wait for them to simply go away. That
will take a while. Specifically, the numerous crowd sourcing
aspects previously disclosed should all be implemented with clear
delineations between information derived from clinically licensed
sources versus everything else. Color schemes, specially designed
logos and text treatments . . . such technically implemented
graphic clues should all be used as templates to demarcate
"results" information sent back to users of these systems. As an
example, if automated processes produce probability results which
tend to indicate concern over some skin patch or patches, any
positivistic results sent back to a user should be packaged in
uniformly recognizable graphic forms which are associated with the
classic response of " . . . comparisons of your results with
thousands of others tend to suggest that you seek licensed medical
examination . . . " On the other extreme, if results tend strongly
toward a "normal" or benign classification for all submitted
imagery, the graphic formatting and language can indicate the null
result, yet still reinforce the notion that users should
nonetheless use their instincts in seeking licensed medical
assistance despite the null results of some particular session.
[0179] These ideas can readily be implemented by considering them
as a discrete filter stage sitting between the software/analysis
engines that are tasked with producing probabilistic results on
submitted imagery, and the GUI stages of user interaction. This
filtering is not at all a GUI matter; it is fundamentally about
ensuring that centuries' old common medical practices are followed
in the communication with a user. This discrete filtering will by
no means solve the deep cultural tensions inherent in these
activities, but they can form a highly explicit balance between the
truths of both camps described above. The broadest goal is to reach
out to a broader set of actual at-risk individuals, providing
guidance toward the seeking of licensed medical treatment.
Likewise, for those individuals who in actuality are not at risk
for the conditions they are worried about, it is still no place for
an automated service to do anything more than simply indicate null
results. No trace of "assurances" can be part of a response unless
a licensed practitioner is actively involved in a session, with
full disclosure of that involvement and reference to the
professional acceptance of that involvement. All in all, then, this
discrete filter might be named the "best medical practices" filter,
and all communications concerning test results should be mandated
to pass through this discrete filter.
[0180] The classic term "screening" has been used for decades now,
largely dealing with these broader concepts. Though the lay-public
often confuses screening with diagnosis, the medical profession has
put forth enormous efforts to educate the public about their
differences. Furthermore, many medical professionals will consider
any automated service which does not have a case-by-case medical
practitioner involved to not even be worthy of the term
"screening." This is a legitimate viewpoint, especially as the law
allows for any solution vendor or medicinal product manufacturer to
make generic claims toward medical efficacy. But here again the
term "screening" can become a technically implemented element of
the crowd-sourced elements described in this disclosure by simply
presenting results in the fully disclosed context in which those
results were derived. Specifically, deliberately borrowing from
known cultural norms, results can be phrased as "over 1000 other
individuals have submitted images very similar to yours, and
according to an ad hoc survey of those individuals, 73% sought
medical advice . . . " The variations and permutations on these
themes are vast.
[0181] Again, technically, this kind of data and the generation of
such statements require actual crowd-source data gathering and
storage, then linked into a results filter as described above. The
actual process of this particular type of screening is fully
disclosed both in its methodologies as well as in the phrasing of
results. It thus earns the term screening because that's exactly
what it becomes, a crowd-sourced screening phenomena. Its eventual
efficacy will be determined by the quality of its ultimate results
and growth in its user base.
Quick and Economic Whole-Body Skin Screening--Early Melanoma
Screening Room
[0182] Fresh off the topic of screening, this disclosure next
details how the current art of whole-body dermatological
photography can transition toward a fully licensed dermatological
screening test, emulating the cultural norms of pap smears and
colonoscopies.
[0183] The current art in whole-body scanning is illustrated by
Canfield Imaging Systems, which operates imaging centers in cities
throughout the U.S. At these facilities, patients can obtain
whole-body imagery, which is then passed to their physicians for
review. Aspects of the Canfield technology are detailed, e.g., in
documents U.S. Pat. Nos. 8,498,460, 8,218,862, 7,603,031, and
20090137908.
[0184] A basic aspect of an illustrative early melanoma screening
room (EMSR) is simple: build a transparent phone booth (or
cylinder) surrounded with cameras and synchronized lighting. For
example, the booth may comprise lighting with, e.g. 16 to 32 LED
spectral bands (some into the near-IR), and a dozen or two dozen
RGB and/or black and white cameras. (See, e.g., patent application
documents 20130308045, and Ser. No. 14/201,852.) Shaving, or an
alcohol or other skin treatment, may be employed in certain cases.
People get naked or put on a bathing suit, get inside, and raise
their arms--as in the TSA imaging booth. Five or fifteen seconds
later they are done. They can wear small goggles if they like, but
closing eyes, or even having them open, will probably be fine (and
will probably have to be, for FDA approval). Maybe two or three
poses for normal extra data gathering, dealing with odd reflections
and glare, different skin-surface normals, so all in all a
non-surgical, less-than-one-minute affair.
[0185] The computer churns for another 30 seconds conducting image
analysis and comparison with reference data, and either gives a
green light, or, perhaps in a non-alarming way and still "routine,"
a low threshold is set such that a patient is asked to go into a
second room where a technician can focus in on "concern areas"
using existing state-of-the-art data gathering methods on exact
areas, including simple scrape biopsies. (The technician views
results from the scan, with "guidance" from the software, in order
to flag the patient, point out the areas of concern, and instigate
the second-room screening.) Practicing clinicians also can be more
or less involved in the steps.
[0186] This is pap-smear, colonoscopy, cultural 101 kind of
thinking . . . do it first when you are 25, then every 5 years, or
whatever. Get it close to the pap-smear kind of test cost wise, the
rooms themselves shouldn't run over $5 to $10K full manufacturing
cost; no need to get too crazy on the hardware technology.
[0187] The market demand, of course, is to discriminate normal skin
from melanoma and other pathologies. The explicit target would be
detecting earlier and earlier stage melanoma, seeing how early one
can get. Receiver operating characteristic (ROC) curve studies are
the industry norm next step, seeing how quickly true positive
detections can occur before annoying levels of false positives
start to kick in. Since this is meant to be a very early screening
method, this favors tilting the ROC curves toward "detect more," so
that again, a technician can do "no big deal" secondary screening
using existing methods and weed out the slightly larger level of
false negatives due to higher ROC thresholds. So this is also a
cost-based measure, providing better guidance toward "who" should
be getting referred to more expensive existing screening
methods.
[0188] The real point of EMSR is early detection. Increased
quantity of care at current quality levels and current cost levels
is also the point, with averted mortality also being a direct cost
benefit beyond saving a person's life. Even six months, but better
yet 1 to 2 years of advanced detection will produce stunning and
clear increases in survival rates.
[0189] FIG. 5A shows a schematic sectional view looking down into a
cylindrical booth (e.g., seven feet in height, and three feet in
diameter, with an access door, not particularly shown). Arrayed
around the booth (inside, outside, or integrated into the sidewall)
are a plurality of light sources 52 and cameras 54.
[0190] The depicted horizontal ring array of light sources and
cameras can repeat at vertical increments along the height of the
booth, such as every 6 or 18 inches (or less than 6, or more than
18). The lights and cameras can align with each other vertically
(i.e., a vertical line through one light source passes through a
series of other light sources in successive horizontal rows), or
they may be staggered. Such a staggered arrangement is shown in
FIG. 6A, in which successive rows of lights/cameras are offset by
about 11 degrees from each other.
[0191] FIG. 6B shows another staggered arrangement, depicting an
excerpt of the side wall, "unwrapped." Here, successive horizontal
rows of light sources 52 (and cameras 54) are offset relative to
each other. Moreover, in this arrangement, the light sources 52 are
not centered between horizontally-neighboring cameras, but are
offset.
[0192] Although not depicted, the light sources needn't be
interspersed with cameras, with the same number of each. Instead,
there may be a greater or lesser number of light sources than
cameras.
[0193] Similarly, the light sources needn't be arrayed in the same
horizontal alignment as cameras; they can be at different vertical
elevations.
[0194] Light sources and cameras may also be positioned below the
person, e.g., under a transparent floor.
[0195] Desirably, the light sources are of the sort detailed in
applications 20130308045 and Ser. No. 14/201,852. They may be
operated at a sufficiently high rate (e.g., 40-280 Hz) that the
illumination appears white to human vision. The cameras transmit
their captured imagery to a computer that processes the images
according to methods in the just-noted patent documents, to
determine spectricity measurements (e.g., for each pixel or other
region of the imagery). Desirably, errors in these measurements are
mitigated by the techniques detailed in these documents. The
imagery is then divided into patches (e.g., 1, 2, or 5 cm on a
side) and compared against reference imagery, or applied to another
form of classifier. All of the imagery can be processed in this
fashion, or a human or expert system can identify patches of
potential interest for analysis.
[0196] In other embodiments, the patient can stand on a turntable
that rotates in front of a lesser number of cameras and light
sources, while frames of imagery are successively captured. Thus, a
full "booth" is not required. Such arrangement also captures
imagery at a range of different camera-viewing and
light-illuminating angles--revealing features that may not be
evident in a static-pose capture of imagery. (A turntable also
allows hyperspectral line sensors to be employed in the cameras,
with 2D imagery produced from successive lines as the turntable
turns. Such line sensors are available from IMEC International of
Belgium, and capture 100 spectral bands in the 600-1000 nm range.
Of course, 2D sensors can be used as well--including hyperspectral
sensors. One vendor of hyperspectral 2D sensors, sometimes termed
imaging spectrographs, is Spectral Imaging Ltd. of Finland.)
[0197] In some embodiments, 3D reconstruction techniques (e.g.,
SLAM) are applied to the captured imagery to build a digital body
map. In such a map/model, not only the size, but images, of every
suspicious location are recorded over time. In some
implementations, images of the entire body surface can be recorded,
allowing an examining physician to virtually fly,
Google-Earth-like, over the patient's modeled body surface, pausing
at points of interest. If historical images are available, the
physician can examine the time-lapse view of changes at each
location, as desired. Some useful subset of the spectral bands can
be used to do the mapping. If desired, the patient's body map can
be morphed (stretched and tucked and squeezed, etc.) to a
standardized 3D body shape/pose (of which there may be a dozen or
more) to aid in automated processing and cataloging of the noted
features.
User Interface and Other Features
[0198] In reporting results from crowd-sourced data repositories
back to users, care should be taken not to offend. In one aspect,
the user software includes options that can be user-selected so
that the system does not present certain types of images, e.g., of
genitalia, of morbid conditions, of surgical procedures, etc. (Tags
for such imagery can be maintained in the knowledge base, so that
images may be filtered on this basis.)
[0199] The user interface can also allow the user explore imagery
in the database. For example, if the system presents a reference
image depicting a leg lesion that is similar to a lesion on the
user's leg, the user may choose to view follow-on images of that
same reference lesion, taken at later dates--showing its
progression over time. Similarly, if the reference lesion was found
on the leg of a prior user who also submitted imagery showing a
rash on her arm, the current user may navigate from the original
leg lesion reference image to view the reference image showing the
prior user's arm rash.
[0200] Image navigation may also be based on image attribute, as
judged by one or more parameters. A simple parameter is color. For
example, one derivative that may be computed for some or all of the
images in the knowledge base is the average color of a lesion
appearing at the middle of the image (or the color of the pixel at
the middle of the image--if a generalized skin condition such as a
rash is depicted there). The user can query the database by
defining such a color (e.g., by pointing to a lesion in
user-submitted imagery, or by a color-picker interface such as is
employed in Photoshop software), and the software then presents the
image in the knowledge base that is closest in this metric. The
user may operate a control to continue such exploration--at each
step being presented an image that is closest in this attribute to
the one before it (but not previously displayed).
[0201] Similarly, the user interface can permit user navigation of
reference images based on similarity in lesion size, shape,
texture, etc.
[0202] Hair on skin can be a useful diagnostic criterion. For
example, melanoma is aggressively negative for hair; hair is rarely
seen from such growths. So hair depictions should be included in
the knowledge base imagery.
[0203] However, hair sometimes gets in the way. Thus, certain of
the processing may be performed using image data from which the
hair has been virtually removed, as detailed earlier.
[0204] The user interface can allow the user to tap at one or more
locations within a captured skin image, to identify portions about
which the user is curious or concerned. This information is
conveyed to the central system--avoiding ambiguity about what
feature(s) in the image should be the focus of system processing.
The user interface can allow the user to enter annotations about
that feature (e.g., "I think I first noticed this when on my Las
Vegas vacation, around May 20, 2013").
[0205] Additionally, or alternatively, when the central system
receives a user image, and processes it against the knowledge base
information, it may return the image with one or more graphical
indicia to signal what it has discovered. For example, it may add a
colored border to a depicted lesion (e.g., in red--indicating
attention is suggested, or in green), or cause an area of the
screen to glow or strobe. When this image is presented to the user,
and the user touches or otherwise selects the graphical indicia,
information linked to that feature is presented, detailing the
system's associated findings. A series of such images--each with
system-added graphical indicia (e.g., colored borders)--may be
rendered to illustrate a time-lapse evolution of a skin condition,
as detailed earlier.
[0206] Skin is our interface between our body and our world; our
interaction with our environment is largely recorded on this thin
layer. The present technology helps mine some of the wealth of
information that this record provides.
Rainbow Mode
[0207] Reference was made to gathering multiple frames of imagery
under different, spectrally tuned illumination conditions, such as
by using illumination sources (e.g., LEDs) tuned to different
wavelengths.
[0208] As detailed in cited publication 20130308045 and application
Ser. No. 14/201,852, N different spectral illumination sources
combine with M different spectral detectors (e.g., the three
different color filters overlaying a smartphone photodetector
array) to yield up to N*M different sets of image data. From this
richness of different image data, a rich set of different features
can be discerned.
[0209] Those patent applications further detailed how ambient
lighting effects can be largely removed, even if the
spectrally-tuned illumination amounts to just 10% or so of the
total illumination.
[0210] In accordance with a further aspect of the present
technology, illumination at different spectral wavelengths is
provided by illumination from a smartphone screen. One such method
captures imagery using a smartphone's front-facing camera (i.e.,
the camera on the same side of the phone as the touchscreen),
instead of the usual rear-facing camera. The field of view captured
by the front-facing camera is then illuminated--at least in
part--by light from the smartphone screen. This screen is
software-controlled to present a sequence of different illumination
patterns or colors ("rainbow mode"), during which different frames
of imagery are captured.
[0211] Smartphone and other screens commonly emit "red," "green"
and "blue" light--each with a particular spectral profile. (This
profile typically varies from one type of smartphone to
another--due to different display technologies, and sometimes
varies among smartphones of the same type due to process
variations.) Importantly, these spectral profiles never exactly
match the red-, green- and blue-Bayer sensor pixel spectral
profiles--giving rise to the multiplicative effect noted above.
[0212] For example, some "blue" illumination from the display
screen will slightly "light up" green Bayer-filtered pixels.
"Green" illumination from the display screen will excite all three
(R/G/B) Bayer-filtered photosensors. "Red" from the display will
excite both red- and green-filtered photosensors. This example
gives seven cross-combinations, or "channels," which the cited
patent disclosures discuss in great detail, e.g., describing and
characterizing how these channels vary in quality and information
content. (While there are nine combinations of screen colors and
photosensor colors, blue and red are sufficiently
remote--spectrally--that the coupling effect is essentially
nil.)
[0213] OLED displays are coming into widespread use (e.g., the
Samsung Galaxy SIII, S4 and S5) and offer increased brightness and
wider gamut, compared with previous technologies.
[0214] Flexible displays are also beginning to appear commercially.
These are attractive to illuminate 3D relief features at close
imaging distances, as the display is operated to sweep illumination
from one side to the other.
[0215] Autostereoscopic displays (commonly including parallax
barriers) can also be used, and can create structured
illumination.
[0216] One illustrative embodiment uses rainbow mode in capturing
and processing frames of image data from a user's face. In a
particular implementation (which may be called Face-Chek), the
motion and/or pose of a smartphone is sensed, and used to switch
between data collection and data presentation modes.
[0217] As is familiar, the motion and pose of a smartphone can be
discerned by reference to data from the phone's onboard
accelerometers, magnetometers and gyroscopes--each commonly 3D.
(Motion can also be assessed by reference to apparent movement of
imagery captured by the phone camera.)
[0218] In data collection mode, the user waves the phone around the
head (and optionally scalp), capturing frames of imagery with the
front-facing camera, from different vantage points. During such
motion, the phone screen is displaying a sequence of different
illumination patterns/colors. Software analyzes the imagery
captured under these various illumination/viewpoint conditions to
identify features of potential concern, classify features by type,
create longitudinal image sequences illustrating changes in
particular features, etc. When the device is thereafter held static
by the user for viewing, this information is presented. (This
static pose is typically one in which the screen is inclined
upwardly, with the base of the screen substantially horizontal,
i.e., within ten degrees of the horizon).
[0219] The screen illumination can be of various types. At some
update rates, human persistence of vision causes the illumination
to seem uniform, e.g., all white. At slower rates, different colors
or patterns flash across the screen.
[0220] A simple arrangement sequentially displays screens of
all-red, all-green, all-blue, in cyclical fashion. In a variant,
the phone's "torch" (i.e., illumination flash) is operated in a
fourth phase of the sequence, giving four different illumination
states.
[0221] In another arrangement, solid screen colors are still
employed, but this time with combinations of the red/green/blue
primaries (yielding what may be termed cyan, magenta and
yellow).
[0222] In some arrangements, the transitions between colors are
abrupt. For example, a red screen can be maintained for a sixth of
a second, and then switch to blue for the next sixth of a second,
etc. In other arrangements, the transitions are blended. For
example, a displayed solid color may be updated thirty times a
second. At a first frame, red is presented. At the second frame,
20% of the red pixels are changed to green. And at the third frame,
20% more of the red pixels are changed to green. A
seemingly-continuous smear of colors results (but is actually 15
different colors. Twice a second the display is all-red. Ditto for
all-blue and all-green.
[0223] Capture of image frames by the camera is synchronized to the
different frames of illumination. In the example just-given, the
camera may capture six frames of imagery per second (i.e., two with
all-red illumination, two with all-blue illumination, and two with
all-green illumination).
[0224] Skin topology features are best revealed by illuminating the
skin obliquely, at various different angles. This can be done by
operating the screen to present illumination from different parts
thereof, at different times. The rest of the screen can be kept
dark (black).
[0225] One such arrangement is shown in FIG. 7. The display screen
at the top of the figure is all-dark (black). After a fixed
interval a colored band appears along the left edge of the screen.
A further interval later it shifts one band-width to the right. In
similar fashion the color band marches across the screen. (While
six discrete steps are illustrated, a greater or lesser can be
used.)
[0226] After the colored band has finished its march across the
screen, a dark screen is then presented, followed by a similar
march of a band of a different color.
[0227] In some embodiments, the sequence of colors (e.g., of the
FIG. 7 bands) is sequential, e.g., red, green, blue (or red, green,
blue, cyan, magenta, yellow, etc.). In others, the sequence of
colors is random.
[0228] Likewise with the FIG. 7 progression of the colored band
from left to right. In some arrangements this pattern is repeated,
with different colors. In others, the direction of the band's
movement is changed from one cycle to the next. For example, after
the red band of FIG. 7 has marched to the right of the screen in
one cycle, the next cycle may have a band of color march from the
top to the bottom. Or from the right to the left. Or from the
bottom to top. Again, the sequence can repeat, or random directions
and/or colors can be used.
[0229] FIG. 8 shows a variant in which two bands--of different
colors--move across the screen. As in the arrangement
just-described, the color of the horizontal band in different
cycles can follow a repeating pattern, or it can be selected
randomly. Similarly with the direction of the horizontal band's
movement (top-to-bottom, or bottom-to-top). Likewise with the
vertical band.
[0230] FIG. 9 shows yet another variant, in which blocks of
different colors appear at different positions on the screen. As
before, the sequence of colors, and positions of the blocks, can
follow a repeating pattern, or either/both can proceed in a random
sequence.
[0231] (In this and other embodiments discussed herein, the device
can be an iPhone 5, which has a display that is four inches in
diagonal measurement, and has a 1136.times.640 pixel resolution,
i.e., 326 points per inch.)
[0232] FIG. 10 further considers certain aspects of the
illumination geometry. At the top of the figure, a color band is
displayed at one end of the smartphone screen. Light from this band
illuminates a location 102 on the skin at an angle of 21 degrees
(relative to a tangent 104 to the skin surface).
[0233] A few instants later, the band has moved to near the middle
of the screen, as depicted in the middle of the figure. Here, light
from this band (which may now be of a different color, or not)
illuminates the skin location 102 at an angle of 40 degrees.
[0234] A few instants later, the band has moved to hear the
opposite end of the screen, as depicted in the bottom of FIG. 10.
Here, light from this band illuminates the skin location at an
angle of 103 degrees.
[0235] As before, the phone captures a frame of imagery under each
of these different illumination conditions, using a camera 106.
[0236] It will thus be recognized that the FIG. 10 arrangement
collects imagery of skin location 102 as illuminated from a variety
of different angles. If the color of the band changes as it marches
across the display, such arrangement collects imagery of the skin
location with illumination that is diverse both in angle and
spectrum.
[0237] While the phone is stationary in FIG. 10, in actual
practice, the phone may be moved by the user to different positions
relative to skin location 102 while the color band marches across
the display screen. Thus, in some embodiments, imagery is captured
having diversity in illumination angle, illumination spectrum, and
viewpoint.
[0238] (To fit three illumination scenarios in the FIG. 10
illustration, the phone is depicted as closer to the skin than may
generally be the case. A more typical imaging distance is 4-6
inches.)
[0239] The oblique illumination afforded by colors presented on
different parts of the screen, together with motion that moves the
camera to different viewpoints, helps in revealing millimeter-scale
3D profiles of the skin. Such profile information can aid in
classifying certain skin conditions, e.g., dryness, scaliness, age
wrinkles, sunburn, etc.
[0240] By producing a sequence of, for example, 30 image frames
over a one second period, where, for example, 10 different states
of rainbow illumination were occurring over that one second period,
an information diversity situation is created that goes beyond just
the spectral combinations of the display RGB and the sensor RGB;
illumination angle effects are now also included in this large
gathering of imagery data. As is well known in machine learning and
the wide field of classification of objects, it may not always be
possible to analytically understand this larger complexity
represented in the data. However, the very existence of this extra
complexity will allow for higher dimensional discrimination of one
class of "thing" over another class of "thing." In the case of this
technology and skin, this can involve the simplest of questions
such as "is this skin drier or more moist than that skin?" The way
this is done is through classic training, where known samples of
drier skin, and known samples of more moist skin, all get sampled
via these rainbow illumination ways, and their resultant higher
dimensional differences and unique characteristics all get "trained
in" to this otherwise incomprehensible set of data. Modern
classification approaches routinely deal with data vectors having
100 or even 1000 or more dimensions of related information. A patch
of skin having been illuminated with all these spectral
combinations and from these various spatial directions can easily
give rise to dozens or hundreds of bundled data attributes at
millimeter by millimeter scales represented by the pixels of the
camera. Spatial derivatives of these data, e.g., how does the "red
light from the left pixel datum" change from this pixel to ten
pixels over, innately carry discrimination information between a
new red rash that might be lumpy versus the less lumpy nature of a
hickey, to use a deliberately out-there example. Thus, perhaps,
boyfriends and girlfriends can quickly check for any youthful
infidelities as but one tiny application for rainbow-derived data
captures.
[0241] Sunburn analysis is another application where
spatial-spectral rainbow diversity can enrich the identification
and discrimination power of captured imagery. The emergence of even
very small blistering, perhaps very difficult to see even with a
magnifying glass, will nevertheless exhibit different far-field
optical characteristics over, say, non-blistering but nevertheless
still-painful lesser degree burns. Dryness detection of skin was
already mentioned, whereby with rainbow diversity, it is possible
to build up a "scaling system" of degrees of dryness, such that
users can make their own choices about when and when not to apply
various skin moisturizers. The aging of skin is another area where
there are a vast number of people interested in better
understanding not simply what to do about aging skin, but to
understand the state of their own skin and to understand how they
might be able to treat and track the various remedies they employ
in the battles against aging. The rainbow spectral-spatial
diversity here again can provide a richer set of direct empirical
samplings of the intricacies of wide varieties of skin conditions
which, after all, derive from a very complicated three-dimensional
structure, namely human skin.
[0242] The general principles of shining spectrally shaped light
from some angle in space can of course be accomplished by LED's
that are somewhat collimated or even tunable lasers. The broadest
principle being taught here is that though the microbiology of
specific skin conditions or skin topologies may be too complicated
to create recognizable patterns from this diversity of lighting
angles and spectra, it nevertheless can still be measured and used
to discriminate condition A from condition B, or even stages of
progression of some singular condition. As machine learning
practitioners understand, the resulting data vector populations
disperse themselves in higher dimensional vector spaces in such a
way that by training on known condition types, generating
signatures of the populations a la SVM types of boundary conditions
on these types, then comparing unknown test cases against these
populations can be a method for discriminating conditions which
otherwise might look nearly identical to a normal color camera not
employing these rainbow sampling techniques.
[0243] (Additional information regarding acquiring data from
multiple-viewpoint imagery, e.g., to detail surface attributes, is
detailed in applicant's publication 20080112596.)
Audio, Etc.
[0244] In accordance with other aspects of the present technology,
audio (and other physiologic data) is collected and used in manners
like the skin imagery herein.
[0245] For example, one particular embodiment employs regression
analysis on a set of audio data to characterize false conclusions
that should not be drawn. (Culling the false helps in identifying
the truth.) Another compares extracted features against templates
of "normal" features, to identify anomalous signals that should be
reviewed by a qualified physician.
[0246] Patent publications 2002085724, 2005078533, 2008046276,
2008062389, 2010045210, 2011009759, 2011021939, 2011096820,
2011076328, 2012043018, 2012090303, 2013016584, 2013061484,
2014012149, WO0209396, and WO13156999 detail a variety of
technologies useful in collecting and processing physiological
sound information, which are suitable for use with the arrangements
described herein.
[0247] Among the different audio data collection arrangements are
bell and diaphragm type pick-ups, acoustically coupled to one or
more microphones. Such a pickup can be provided in a separate
unit--coupled to a portable device (e.g., smartphone) by wire
(e.g., employing the headphone/mic jack) or wirelessly (e.g.,
employing Bluetooth). Alternatively, such a pickup can form part of
the portable device, either permanently, or by an accessory unit
that is removably attached to the device body. An example of the
latter is a downwardly-opening funnel-like member (e.g., made of
plastic) that friction-fits over the lower inch or half-inch of a
smartphone body, channeling sounds from the wide end of the funnel
up to the microphone(s) normally used for telephone
communication.
[0248] In other arrangements audio sensing can be done by worn
microphones. In some embodiments, one or more microphones are
provided in a band (e.g., a wrist- or waist-band) worn by a user
(or worn by a clinician, for probing a user). In others, acoustic
sensors are integrated in clothing or other garments. By
positioning microphones at different locations on the body, the
spatial origins of different sounds can be better determined,
aiding their diagnostic significance. In still other arrangements,
head-worn microphones can sometimes be employed (e.g., Google
Glass-like arrangements).
[0249] To reduce the influence of spurious (i.e., non-physiologic)
audio found in the ambient environment, one or more other
microphones can be employed to sense the ambient audio, so it can
be removed from the sensed physiologic audio, using known noise
cancellation techniques. (Smartphones are increasingly provided
with multiple microphones; one or more of these can be used to
enhance the sensed physiological signals.)
[0250] A variety of diagnostically relevant acoustic signals can be
sensed. These include heart sounds and other cardiovascular sounds
(including murmurs, bruits, and other blood flow noises), lung and
other respiratory sounds (including crackles, rales, rhonchi,
wheezes, coughs, snoring and other air flow noises), bowel and
digestive sounds, joint noises (e.g., pops and creaks), as well as
speech and other vocalizations.
[0251] In gathering data for analysis, and for comparison against
reference data, a variety of processing techniques can be
employed.
[0252] One processing technique characterizes and strips-out
positioning sounds, e.g., when a microphone is moved and rubbed
against a person's skin, before settling at a final position for
data collection. A classifier can be trained to recognize such
positioning sounds, so that they are not used in diagnostic
processing.
[0253] Another processing technique is noise-cancellation, e.g., as
noted above, and in certain of the cited patent documents. A
suitable wavelet-based denoising arrangement is detailed in Messer,
et al, Optimal Wavelet Denoising for Phonocardiograms,
Microelectronics Journal 32.12, pp. 931-941 (2001). Spectral
filtering can also be employed, when same is desired based on
measurement context.
[0254] Other signal processing techniques useful with physiologic
signals may be broadly classified into the following overlapping
areas: [0255] 1. Prediction based techniques--useful for
cardiovascular and respiratory sounds that have a predictable
(repetitive) structure [0256] a. Prediction error can be useful in
detecting abnormalities in heart beats and also in isolating
noise-like signals, e.g., a murmur, in the presence of a stronger
heart beat signal. [0257] b. Transient signals are not easily
predictable either. So, in analyzing a wet cough signal, there may
be a transient component which will be present in dry cough but in
wet coughs there will also be a predictable component which will be
absent in the dry coughs (based on an excitation model for coughs).
[0258] 2. Time-frequency techniques--FFTs, Spectrograms etc. [0259]
a. Spectrograms can be analyzed for high frequency vs low frequency
signals--noise-like signals have higher frequency content--air flow
sounds, murmurs etc. [0260] 3. Transient analysis--short frame
analysis [0261] a. Pops and crackles are transient signals and they
can be detected/analyzed using short frame audio analysis [0262] b.
Energy envelope is also useful in transient signal analysis [0263]
4. Fingerprinting techniques [0264] a. With enough training
examples, audio fingerprinting features and matching techniques
from the field of music and video recognition can work for
physiologic sounds. (Examples of audio fingerprinting and matching
are detailed in patent publications 20070250716, 20070174059 and
20080300011 (Digimarc), 20080276265, 20070274537 and 20050232411
(Nielsen), 20070124756 (Google), U.S. Pat. No. 7,516,074
(Auditude), U.S. Pat. No. 6,990,453 and U.S. Pat. No. 7,359,889
(Shazam), 20050141707, 20050259819, and 20060075237 (Gracenote),
and U.S. Pat. No. 8,656,441 (Cox).) [0265] b. One example of a
fingerprinting based diagnosis is to collect "healthy" audio data
(when the patient is healthy) and then analyze any deviation from
the signatures or fingerprints of this healthy data to determine
pathologies in future diagnostic examinations.
[0266] Such processing can provide a variety of "features" that can
be compared with reference data in assessing whether a signal is
normal or anomalous (and, if the latter, used to help identify what
the anomaly is--or is not).
[0267] One approach is to use an auto-regressive model to
parameterize the sensed sounds. This is the approach employed,
e.g., by Harma et al in Time-Varying Autoregressive Modeling of
Audio and Speech Signals, Proc. of the EUSIPCO, pp. 2037-2040,
2000.
[0268] Another approach uses features including the MFCC
(Mel-Frequency Cepstral Coefficients) and PLP (Perceptual linear
predictor) that are used in the automatic speech recognition
field.
[0269] Coughs, snores, bruits, and other isolatable or cyclically
recurring sounds can be parameterized, in one respect, by
identifying the time interval over which a threshold (e.g., 80%)
portion of the spectral energy is expressed, and the smallest
frequency bandwidth (characterized by low and high frequencies)
within which a threshold (e.g., 90%) portion of the spectral energy
is expressed. (These low and high frequency bounds can also
independently serve as useful features.)
[0270] A large number of other parameters and features can
similarly be derived from a spectrogram of the audio, as
illustrated by the following Table 1, adapted from the thesis by
Glaeser, Analysis and Classification of Sounds Produced by Asian
Elephants (Elephas Maximus), Portland State University, 2009. (In
this table, the just-noted features are essentially features M5,
M6, M3 and M4, respectively.)
TABLE-US-00001 TABLE 1 Parameter Units Description Type M1-M6:
Feature box Start Time sec Lowest time index in bounds that
encompass the temporal (M1) inner 90% of the signal strength in the
time envelope. End Time sec Highest time index in bounds that
encompass the temporal (M2) inner 90% of the signal strength in the
time envelope. Lower Hz Lowest frequency index in bounds that
frequency Frequency encompass the inner 90% of the signal strength
in (M3) the frequency envelope. Upper Hz Highest frequency index in
bounds that frequency Frequency encompass the inner 90% of the
signal strength in (M4) the frequency envelope. Duration sec Width
of feature box: M2-M1 temporal (M5) Bandwidth Hz Height of feature
box: M4-M3 frequency (M6) M7-M14: Central values and variation Uses
measures that do not assume normality: median, quartile ranges,
quartile skewness, concentration. Median Time sec Time at which 50%
cumulative signal energy is temporal (M7) reached. (Measured
relative to start of sound, so M7 was calculated as M7new = M7 -
M1) Temporal sec Concentration of a sound around the median time
temporal Interquartile (M7) measured as the duration of the
interquartile Range range of signal energy (Q3-Q1). (M8) Counts
energy going forward and back from the median time (M7). Q3 =
median + 25% of signal energy Q1 = median - 25% of signal energy
Temporal sec Concentration of a sound measured as the time temporal
Concentration span encompassing loudest 50% of time envelope (M9)
values. Counts energy from the loudest parts down towards the
smallest parts regardless of where the parts occur in time.
Temporal none Skewness of energy along time axis within temporal
Asymmetry interquartile range (-1.0 to 1.0) (M10) Median Hz
Frequency at with 50% cumulative signal energy frequency Frequency
is reached. (M11) More stable than extreme values of LowerFreq and
UpperFreq in varying noise conditions. Spectral Hz Concentration of
a sound around the median frequency Interquartile frequency (M11)
measured as frequency range of Range interquartile range of signal
energy (Q3-Q1). (M12) Counts energy going forward and back from the
median frequency (M11). Q3 = median + 25% of signal energy Q1 =
median - 25% of signal energy Spectral Hz Concentration of a sound
measured as the frequency Concentration frequency span encompassing
loudest 50% off (M13) requency envelope values. Counts energy from
the loudest parts down towards the smallest parts regardless of
where the parts occur in time. Frequency none Skewness of energy
along frequency axis within frequency Asymmetry interquartile range
(-1.0 to 1.0) (M14) M15-M20: Peak intensity Time of Peak sec Time
of single loudest spectrogram cell. temporal Cell Intensity Time of
the cell containing the peak intensity. (M15) (Measured relative to
start of sound, so M15 was calculated as M15new = M15 - M1)
Relative % Relative time of peak intensity (M15/M5) temporal Time
of Peak Cell Intensity (M16) Time of Peak sec Largest value in time
envelope, which is the temporal Overall largest vertical sum of the
spectrogram over all Intensity frequencies. Time of the peak
intensity in the (M17) trimmed time envelope. (Measured relative to
start of sound, so M7 was calculated as M17new = M17 - M1) Relative
% Relative time of peak intensity (M17/M5) temporal Time of Peak
Overall Intensity (M18) Frequency of Hz Frequency of cell
containing the peak intensity. frequency Peak Cell Intensity (M19)
Frequency of Hz Frequency of peak intensity in the trimmed
frequency Peak Overall frequency envelope. Intensity (M20) M21-M24:
Amplitude and frequency modulation (variation of amplitude and
frequency over time) AM Rate Hz Dominant rate of amplitude
modulation. amplitude (M21) Frequency of the maximum rate in the
power spectrum of the trimmed time envelope. AM Rate Hz Variability
of amplitude modulation measured as amplitude Variation the width
of peak at M21-6 dB. (M22) Values are discretized because at 6 dB
down from the peak, the widths may be a only a few bins wide so the
values are integer multiples of the bin width. FM Rate Hz Dominant
rate of frequency modulation. frequency (M23) Frequency of the
maximum rate in the power spectrum of the trimmed frequency
envelope. FM Rate Hz Variability of frequency modulation measured
as frequency Variation the width of peak at M23-6 dB. (M24) (How
much the rate of change varies, may be related to inflections and
steepness of upsweeps and downsweeps) M25-M28: Fine features of
harmonic structure, shifts in periodicity, frequency change, rate
of change in frequency direction of Cepstrum Hz Harmonic structure
structure Peak Width Average width of peaks (harmonics) in power
(M25) spectrum. Peak width is measured at 6 dB down from maximum
value. At 6 dB down from the peak, the widths may be a only a few
bins wide (like M22 and M24), but M25 is an average of integers so
the values are not discretized. Narrow peaks means narrowband/tonal
harmonics. Overall Hz Entropy, shifts in periodicity structure
Entropy Distribution of energy across frequency blocks in (M26) a
given time block. Shift from periodicity and linearity to chaos.
Change in noisiness v. tonality. Upsweep Hz Direction of frequency
change frequency Mean Measures how much the frequency increases.
(M27) Average change in median frequency between successive time
blocks, weighted by total energy in the block. Inflection points
with rising and falling frequencies throughout call result in a low
M28 (closer to 0) compared to a consistent directional change.
Measure is weighted to emphasize contribution of louder signal
components. M27 < 0 means frequency is decreasing. Upsweep %
Rate of directional frequency change frequency Fraction Counts the
number of times the frequency content (M28) increases. Fraction of
time in which the median frequency in one block is greater than in
the preceding block, weighted by total energy in the block.
Indicates how much of the call has a directional change in the
frequency. Inflection points with rising and falling frequencies
throughout call result in a high M28, just as a consistent
directional change. Measure is weighted to emphasize contribution
of louder signal components. M28 always positive. M29: Signal
strength Signal-to- dB Signal to noise ratio within the sampled
sound. amplitude Noise Ratio Ratio of the signal power (loudest
cell) to the (M29) noise power (power of cell at 25.sup.th
percentile). Cells are ranked low to high and the cell at the
25.sup.th percentile represents noise. (25.sup.th percentile is
used because the sound likely takes up less than 75% of the total
spectrogram cells.) Measurement assumes that the within the
annotation box at least 25% of the cells are without a focal
signal.
[0271] An ensemble of some or all of the twenty-odd parameters just
detailed (as well as others) can be computed for a sensed sound,
and compared with reference data to discern similarity to (or
deviation from) reference ensembles of parameters--either
individually, or in statistical fashion (e.g., a particular
respiratory sound is two standard deviations away from what may be
regarded as the median for subjects of similar age, weight and
gender). The reference data may have been collected solely from a
single person over time (e.g., a longitudinal record of
earlier-sensed physiologic sounds from that person), or from a
collection of individuals--commonly a grouping that is
demographically similar (e.g., 40-50 year old healthy males
weighing between 170 and 190 pounds).
[0272] One particular example concerns detection of bruits in a
major artery. This can be predictive of a stroke. The user may
periodically place a phone or other audio sensor over the femoral
(or carotid) artery. Five or ten seconds of collected sounds can be
converted into features, as described above, and these features can
be compared with features derived from known bruits sounds. If the
comparison indicates similarity beyond a threshold degree (e.g., a
feature distance below a threshold value), the user can be advised
to have their arteries checked for occlusion.
[0273] Patent publications 20070265508, 20110021939, 20110196820
and 20130261484 detail a variety of other ways that biometric
signals can be processed, e.g., for comparison.
[0274] As noted, speech and other vocalizations also have
diagnostic value. Pitch, timbre, rhythm, pace, and volume (and
variation in same), are some of the vocalization attributes that
can be monitored. Changes from historical norms are sometimes
symptoms or precursors of different conditions, such as depression,
stroke, alcohol poisoning, respiratory illness, etc.
[0275] Depression, for example, is often accompanied by slower and
quieter speech, with reduced variation in pitch. Respiratory
illness can be discerned from lower-pitched speech, with
rougher/coarser timbre (e.g., due to swollen vocal cords).
[0276] Coughs may be characterized by characteristics such as
frequency and type (e.g., a dry cough--staccato in nature, with a
sharp onset, short duration and dominant high frequency components;
and a wet cough--commonly the opposite). A user's cough may be
matched to prototypical coughs (the user's own, or others) on a
"fingerprint" basis, such as employing a collection of the features
detailed in Table 1, above. A user's current cough may be matched
to a previous episode of user coughing, on a prior date. Recalling
other physiologic information from around that prior date may
presage upcoming symptoms, e.g., elevated body temperature, runny
nose, etc.
[0277] Finer classification of coughs can be achieved with a
sufficiently large collection of reference data. A wet cough
originating from irritation of the upper airway (e.g., mucus in the
large bronchi) exhibits one set of features, whereas a cough
originating from the lower airway (e.g., pneumonia in the lungs)
exhibits a different set of features. A distance measure can be
employed to assess whether the set of features characterizing a
user's cough are closer to the former or the latter; the relative
distances provide a confidence metric. More sophisticated
classifier arrangements can also be employed.
[0278] (The audio characteristics of coughs--most especially
pitch--depend, in part, on dimensions of the acoustical bodies
involved. Thus, in selecting reference data for comparison, it is
desirable to pick sounds captured from persons of the same gender,
and about the same age, weight, height and--if known--lung
capacity. If such a closely-matched set of reference data is not
available, the feature matching operation can rely less on absolute
pitch-related features, and more on other features.)
[0279] An alternative implementation to explicit distance measures
is provided by classical machine learning methods. In this case, a
database is collected, consisting of appropriate audio captures,
together with tag data indicating presence of the specific types of
coughs to be identified. The audio is then processed to provide a
rich set of features, which form the input to a machine learning
paradigm (e.g. a Support Vector Machine (SVM), or an Artificial
Neural Network (ANN). Additionally, the database should include
metadata to indicate gender, age, height, weight, etc. This
metadata is then provided as additional features to be learned.
Thus, the learning process automatically takes these variables into
account (to the extent to which the database is varied enough to
span this metadata space). In the case of an ANN, a single network
output may be provided for each cough type to be recognized; a
specific cough type may then be identified by choosing the cough
type with the strongest response over a predetermined threshold
(assuming exclusivity among cough types). In the case of an SVM,
coughs may be classified into many (>2) classes, based on the
design of several binary classifiers. Two popular methods are "one
vs. rest" and "one vs. one."
[0280] Medical practice, to date, has tended to classify coughs
only in gross senses (e.g., wet/dry). With the present technology,
and with widespread collection of coughing sounds, more nuanced
distinctions may be found in coughs--allowing, e.g., the causation
of a particular cough to be more accurately determined. Thus, the
present technology can help reveal previously undiscovered
knowledge.
[0281] Likewise, analysis of a large corpus of audio physiologic
data (and derivatives), and correlation with diagnostic ground
truth (e.g., evaluations from physicians), can find small clues
that reliably indicate big problems. For example, it may be
discovered that a consequence of carbon monoxide poisoning is a
particular change in the high frequency component of inhalation
sounds sensed from the lower lungs. Similarly, it may be discovered
that certain types of strokes are commonly foreshadowed by a change
in the pronunciation of diphthongs (e.g., as in "oil"). When user
audio and diagnostic information becomes available for analysis in
a Big Data sense, a universe of such statistically-reliable
correlations are likely to be found. Thereafter, a user's portable
device can monitor sensed sounds (and other sensed physiologic
data) for such clues (e.g., comparing current sound signals with
historical data), and alert the user to maladies--both present and
upcoming--that the user may not recognize.
[0282] Collections of reference audio data are not yet as readily
available as, e.g., reference collections of mole imagery. However,
such reference information can be crowd-sourced in the same manners
as for imagery. Since audio information is straight-forward to
collect in continuous fashion, the smartphone (or other device) of
each user can serve as a collection agent, and forward large
amounts of audio data (or features derived from the audio data) to
a cloud repository in a relatively short time.
[0283] Ground truth diagnostic data concerning such audio is harder
to compile. Patients commonly don't consult physicians concerning
unfamiliar coughs (as they might for unfamiliar moles); only if a
person's respiratory symptoms become severe is a physician usually
involved. Moreover, pulmonary, bowel, and other audio signals
escape the user's normal attention, so irregularities in those
signals normally don't prompt professional consultations.
[0284] Still further, physicians do not normally record patients'
physiologic sounds--unlike the practice of photographing patients'
skin conditions. Rather, a physician typically just listens to a
cough, or listens to sounds heard through a stethoscope, and offers
a diagnosis based on what was just heard. However, with the
proliferation of electronic medical records, and the movement
towards data driven medical protocols and auditable outcomes, the
digital collection and archiving of sensed patient data--including
coughs, stethoscope sounds, and all manner of other physiologic
signals (e.g., anatomic imaging by various radiological
techniques)--is expected to become more widely practiced. Thus,
electronic medical records may soon provide both captured data and
associated diagnostic information, which can serve as ground truth
in connection with the present technology, eventually leading to
the reliable statistical knowledge that comes with Big Data.
[0285] (In other arrangements, the physician's medical records are
not employed. Instead, a user may enter data in a personal
life-log, recounting a visit to the doctor, together with the
doctor's diagnosis. Such information is then associated with audio
that is life-logged from the user--before and/or after the doctor
visit. A small corpus of training audio, and associated diagnostic
conclusions, are also available from medical schools, where they
are used in training new physicians.)
[0286] While the focus of this discussion has been on audio, it
will be recognized that the same principles can be applied to
collection and processing of other physiologic information. Without
limitation, this includes blood pressure and blood sugar, electric
signals from the heart, brain and nervous system, etc. A range of
different sensors can be employed, including electric, vibration,
optical, stress, strain, chemical, etc.
[0287] A variety of multi-sensor, phone-based medical devices are
known from the prior art, e.g., as shown in patent publications
20050124375, 20090030286, 20100056880, 20120059271 and
WO2013156999. Scanadu has publicized its Scout and Scanaflo
offerings, which can sense temperature, blood pressure, heart rate,
oximetry, ECG, heart rate variability, stress, and urine
chemistry--many using optical techniques. (Patent publications
WO2013066642, WO2013116316, WO2013116253, and WO2014025415 detail
certain of the Scanadu technologies.) Azoi, Inc., similarly has
publicized its upcoming Wello product, in which sensors are
integrated in a smartphone case, and communicate by Bluetooth to a
health tracker app on the phone. The app logs heart rate, blood
pressure, blood oxygen, respiration, heart rate variability (as an
indicator of stress), ECG, temperature, and lung function (with an
accessory spirometer).
[0288] Automated cough detection and rudimentary signal analysis is
the subject of Larson, et al, Accurate and Privacy Preserving Cough
Sensing Using a Low-Cost Microphone, Proc. of the 13.sup.th Int'l
Conf on Ubiquitous Computing, ACM, 2011, and Birring, et al, The
Leicester Cough Monitor: Preliminary Validation of an Automated
Cough Detection System in Chronic Cough, European Respiratory
Journal 31.5, pp. 1013-1018 (2008).
[0289] Many embodiments of the present technology advantageously
consider multiple physiological signals together, for their
diagnostic relevance (e.g., an ensemble of plural signals that
co-occur in a relevant manner) or for signal processing purposes.
For example, in processing signals having a repetitive structure
(e.g., many respiratory and circulatory signals), the signals from
different repeating waveform periods can be averaged, combined,
correlated, compared, filtered or windowed. While the periodicity
can be inferred from, e.g., the audio itself, it can sometimes be
independently determined. For example, for blood flow sounds, the
periodicity can be determined by reference to electric signals
sensed from the heart (e.g., the QRS complex, or the T wave of an
EKG signal). Thus, timing derived from electric signals can be
employed in processing acoustic signals.
[0290] It will be understood that sometimes the body can be
stimulated at one location with an audio signal or pressure
waveform, and the signal can be sensed at another location, to
discern information about the intervening transmission medium.
Fluid behind the tympanic membrane can be sensed in this fashion.
Dehydration can also be so-indicated, based on the degree to which
the skin is stretched or loose. Enlargement of the liver and
constipation can also be discerned in this way, by detection of a
solid (dense) mass under the skin.
[0291] Percussion analysis is used by physicians in clinical
diagnosis for the abdomen and thorax. The resonance properties of
the acoustic waveform resulting from the acoustic stimulation can
be examined to classify the sounds as normal, hyper-resonant,
impaired resonant or dull. Formant analysis of the captured
waveforms yields information about acoustic resonance. Information
about associated symptoms (e.g., pain) can be used in conjunction
with the captured acoustic signals for automated analysis.
[0292] While "sounds" and "audio" commonly refer to
human-perceptible stimuli, these terms are used herein to include
stimuli that may be below, and/or above, the frequency range of
human hearing. MEMS microphones used in many smartphones, and many
of the speakers, are operable well outside of the human hearing
range. Thus, some embodiments of the technology sense data, e.g.,
in the ultrasonic range. (Stimulus can also be provided in this
range.) The ability of the user device to sense sounds outside the
range of human hearing provides capabilities beyond those of
unassisted physicians.
[0293] For example, with an ultrasonic-capable microphone and
speaker, a smartphone may serve as a rudimentary echocardiogram
device--stimulating a portion of the body with ultrasonic audio,
sensing the phase (and amplitude) of the returned signals, and
presenting resultant information on the display screen. By such
arrangement, a variety of at home testing/monitoring can be
conducted, including detection of certain dilated aorta
conditions.
[0294] In classifying sensed physiologic data, hidden Markov
models, artificial neural networks, and deep neural networks can be
employed, borrowing techniques known from the field of pattern
recognition. (Hidden Markov models are also known in analysis of
animal vocalizations; see Ren et al, Framework for Bioacoustic
Vocalization Analysis Using Hidden Markov Models, Algorithms 2, No.
4, pp. 1410-1428, 2009.) Classification trees, support vector
machines, and other discriminatory classification techniques can
also be employed. Such classifiers use feature data from
physiological acoustic data and known diagnoses as training
sets.
[0295] The ensemble of parameters (or features) outlined above can
also be used in unsupervised learning methods to learn complex,
non-linear models of many-dimensional underlying data. Examples of
such techniques include deep belief networks and sparse coding.
(See, e.g., Raina, et al, Large-Scale Deep Unsupervised Learning
Using Graphics Processors, Int'l Conf. on Machine Learning, Vol. 9,
2009.) These techniques are suitable for high-dimensional input
data and can enable inference of latent variables or conditions.
Such deep learning approaches can unearth new patterns or
diagnostic tools using large numbers (even millions) of collected
samples of various physiological acoustic data. A valuable input to
these techniques is the change of physiological acoustic data over
time. Such data can be obtained by sensing the physiological
phenomenon (e.g., heartbeats, coughs, murmurs, etc.) at different
times over multiple days (or longer intervals).
[0296] Note that acoustic features can be combined with other
available diagnostic information (pulse rate, temperature, blood
pressure, etc.) and be provided as input to automated learning and
classification methods (both supervised and unsupervised).
Other Arrangements
[0297] A health app according to one implementation of the present
technology employs a wearable network of sensors to capture and log
a history of physiologic signals, and refer related information to
one or more remote processors (e.g., "the cloud") for large scale
systemic analysis.
[0298] Many existing sensors can be employed in such an
arrangement. One is a wrist-worn activity tracker, such as the
Fitbit Force, Basis, Larklife, Jawbone UP, and Nike Fuelband
products. As is familiar, various sensors in these devices sense
heart rate, temperature, perspiration (commonly based on skin
conductivity), and movement (e.g., based on accelerometer,
magnetometer, or gyroscope sensor data). From these data, others
can be derived, including calorie consumption and sleep stage.
[0299] Another type of sensor is a belt or strap, worn across the
chest, waist or belly (typically horizontally, but alternatively
vertically or diagonally), which can monitor these same parameters,
as well as respiration, dimension (e.g., chest/waist/belly
circumference), and body sounds. (Obesity seems better gauged by
waist- or belly-to-height ratio, rather than weight-to-height
ratio.) A band on the upper arm (e.g., across the bicep) or
leg/thigh can also be employed, as can sensors deployed around the
neck (e.g., in a necklace form) or finger (e.g., in ring form).
Many such sensors can be concealed under clothing
[0300] Blood pressure, blood chemistry, skin imagery data, EKG,
EEG, etc., can also be sensed. As noted, some of the sensors can be
integrated into worn clothing.
[0301] Some sensors can be responsive--in part--to stimulus
introduced into the body, such as a small electrical current,
audio, vibration, etc. For example, electrical conductivity between
two points on the body depends on the amount of intervening fat,
muscle and water, as well as the skin contact resistance (which
varies with perspiration). Some systems for measuring body
composition involve a user standing on two electrical pads, to
sense electrical resistance; less resistance indicates less body
fat, and a lower body fat percentage.
[0302] Audio, vibration, alternating current, and radio
beam-forming arrays can used--either of emitters (e.g.,
piezoelectric actuators) or receptors (e.g., MEMS microphones), and
employed in conjunction with one or more complementary
receptors/emitters on another part of the body, to probe and
localize characteristics (e.g., density, electrical conductivity,
etc.) of the intermediate body mass, using phased array/synthetic
aperture techniques known from other disciplines. (1D arrays can be
used, or 2D; the sensor spacing can be spatially regular or
stochastic.) By such methods, for example, the origin of a
particular respiratory sound can be localized to the upper or lower
lung, or to the trachea. Similarly with a murmur or other blood
flow sound. (Some murmurs are abnormal based on the location where
they originate, or their timing relative to heart phase
actions.)
[0303] Other non-worn sensors can also be employed, such as a weigh
scale, camera, microphone, skin fold thickness calipers,
sphygmomanometer, blood sugar sensor, etc. Some such sensors can be
built into the user's household or office environment. For example,
a weigh scale may be built into the floor in front of a bathroom
sink, and a camera may be positioned to view the user's face when
the user looks into a bathroom mirror.
[0304] Still other sensors may be applied to the body, e.g.,
adhesively or otherwise, for short intervals, as circumstances
dictate. These include EEG and EKG electrodes, piezoelectric
emitters/receptors, etc. Such localized sensors may be employed to
track conditions at sites of particular concern, e.g., bruising or
other wound, cancer site, etc. In some instances, sensors may be
implanted.
[0305] All such sensing apparatus are desirably wirelessly linked,
e.g., to convey data to a user's smartphone, to each other, or to a
monitoring service.
[0306] When a user of an exemplary sensor network participates in a
monitoring service, the logged parameters--or derivative
information based thereon--are eventually sent to the cloud. The
remote service monitors this data--noting and establishing
time-of-day and day-of-week baselines, for different activity
scenarios (e.g., sleep, office work, walking, strenuous exercising,
etc., as classified based on characteristic collections of sensor
data). These baselines can also be associated with different
geographic locations, e.g., as determined by GPS or WiFi, or
otherwise.
[0307] Such a monitoring service may report to the user whenever
the sensed data significantly deviates from expected norms. If a
person's REM sleep pulse is normally between 56 and 60 beats per
second, and one night there is an episode in which the pulse varies
from this range by a threshold amount (e.g., more than 5%, 15%,
30%, or 75%), then a message may be dispatched to the user (e.g.,
by email, text, or otherwise) noting the incident. Possible causes
for the disturbance may also be communicated to the user. These
causation hypotheses can be pro forma--based on textbook
understandings of the noted phenomenon (e.g., caffeine before bed)
discerned from stored rule data, or they can be tailored to the
user--such as taking into account other user- or ambient-sensor
information that might be correlated (e.g., irregular respiration,
suggesting sleep apnea or the like; or an unusually warm room--as
indicated by temperature data logged by a smartphone sensor as
contrasted with historical norms--leading to increased blood flow
for convective body cooling). Such information is also logged in a
historical data store, and may also be sent for e-charting to the
user's physician.
[0308] Part of a health and wellness protocol may involve the user
speaking a particular phrase every day to an associated microphone
sensor (e.g., "Good morning fitband"), for collection of baseline
voice information. In some instances, an interactive dialog may
ensue, with the system (e.g., the user's smartphone) consulting the
user's available biometric signals and prompting--if
appropriate--"You don't sound well" (in displayed or spoken text)
and asking some follow-up questions, to help determine whether the
user's malady is something that needs medical attention. Through
such probing (which may proceed verbally, using speech recognition
technology), the user may reveal that she was refinishing furniture
yesterday evening with a powerful solvent, or was in a venue with
lots of second hand smoke. Based on the collected sensor and verbal
information, the system can consult stored knowledge base
information in advising whether the user should consult medical
personnel.
[0309] Another application of the present technology is in sleep
analysis. Commercial sleep studies often involve instrumenting the
patient with several different sensors, such as a band around the
chest to sense respiratory effort; an O2 sensor on a finger; a
sensor under the nose to detect smoothness of nasal flow; an
accelerometer of the like to sense the vibration that commonly
accompanies snoring, etc. All such information is sent to a data
logging device. The collected information is eventually sent to a
professional for analysis.
[0310] While such arrangement may be the gold standard for sleep
analysis, much useful information can be derived from a much
simpler setup, such as one employing sensors resident in a
smartphone phone, and--if desired--accessory sensors that are
wirelessly sly coupled to the smartphone. For example, vibration
may be sensed by positioning the phone on the bed. Vibrations from
the snoring will couple from the user to the bed, and then to the
phone. (Vibratory amplitude will be diminished, and some dampening
will occur, but useful information nonetheless results. These
factors may be reversed, approximately, by signal processing, if
desired.) Others of the parameters may be derived from analysis of
captured audio. Again, human experience does not give the insight
to discern the small clues evidencing respiratory effort,
smoothness of nasal flow, etc. that are manifest in the sounds of
snoring. But analysis of Big Data archives of such sounds--in
conjunction with ground truth (e.g., captured from gold standard
setups like the one just reviewed)--allows such clues to be sensed
and properly interpreted.
[0311] Another application of the technology involves analysis of
clicking and other noises from user joints (is that degenerative
arthritis, or simple crepitus?). Still another involves stomach and
bowel sounds (e.g., are those the little bowel tones associated
with healthy peristalsis, or high tinkling sounds that may signal
an obstruction?). Yet another involves sounds accompanying urine
flow. Still another involves the sounds of blood turbulence when
blood starts flowing following release in pressure from a blood
pressure measurement cuff. Etc., etc. Again, lay humans typically
don't discern much meaningful data from such sounds and their
variations; many physicians don't do much better. But as
collections of such sounds grow, and are complemented by ground
truth interpretations by physicians, meaning emerges. The
significant clues may not be evident in the raw audio; only by
processing (e.g., by computing one or more of the features detailed
in Table 1) may telling signals become apparent. But as the volume
of reference data goes up, the meaning that can be derived goes up
commensurately.
[0312] In many of the presently-detailed methods, historical user
data is often the best baseline against which to judge current user
data. However, statistical aggregates of large population groups
also form useful comparison standards. For example, even without
historical information, the system can advise a user that her
sleeping respiration rate of 25 breaths per minute is experienced
by persons of similar demographic profile only 1% of the time, and
may merit professional attention.
[0313] As noted, each user's sensed information (or derived data)
is desirably sent for storage in a cloud database service, which
may aggregate data from thousands, or millions, of people. Just as
fitness tracking watches (sometimes termed "activity loggers") have
social network components (e.g., posting Facebook reports of the
GPS route that users run in their daily jogs, with speed, distance
traveled, calories, and heart rate, etc.), so too can a physiologic
monitoring service. Default privacy settings can anonymize the
uploaded data, but users may elect different settings--including to
share selected categories of skin images, biometric information,
activity status updates, etc., with network friends, without
anonymization.
[0314] In some arrangements, the sensed data is associated with
location information--both the location on the body from which it
was collected, and also the geolocation at which the information
was sensed (e.g., latitude and longitude). Data can then be
recalled and analyzed, filtered, presented, etc., based on such
location information. For example, a user can compare an average of
resting pulse measurements taken at work, with such an average
taken at home. Sensed information can also be presented in map
form. For example, a user can query archived data to obtain a map
display that identifies locations at which their resting pulse
exceeded 80. (A suitable map display, detailing where certain data
was sensed by a user, is illustrated in applicant's published
patent application 20130324161.) Again, such information and maps
can be shared via social networking services.
[0315] Historical user data serves as a statistical chronology of
the user's aging process. Again, the user's physiologic signals can
be compared to those of a relevant cohort (e.g., similarly-aged
people of same gender, weight, location, etc.) to reflect whether
the user is aging more or less rapidly than the norm. Relative
aging may be judged by relative physiological condition.
[0316] Generally, aging is accompanied by phenomena including
higher body weight, lower body height, higher BMI, lower lean body
mass (muscle and bone mass), higher blood pressure (both systolic
and diastolic), lower maximum oxygen use (VO2 max--Volume Maximum
Oxygen consumption) under exertion (e.g., on a treadmill stress
exam), decreased visual acuity (e.g., presbyopia--a lessening
ability to focus on close objects), decreased hearing acuity,
decreased skin tightness, etc.
[0317] Such phenomena can be sensed and used to assess
physiological age, as contrasted with chronological age, in known
fashion. In comparing a user's metrics with those of a relevant
cohort, variance indicates the user is either physiologically
younger, or older, than peers. This variance can be tracked over
time. If a user is statistically judged to have a physiological age
of 50 when actually 40, and later have a physiological age of 52
when actually 44, then the user is physiologically older than
peers, but trending in a more healthful direction.
[0318] In similar fashion, trends of other biometric signals over
time, e.g., compared with statistical norms, indicate the
trajectory of a person's health.
[0319] As the collection of reference data and the collection of
ground truth diagnostic information become larger, the frequency
and/or range of errors associated with their use become smaller. At
some point, such a system serves as a statistically reliable
predictor of the future. A user may interact with a user interface
of the system to propose certain changes (e.g., in diet, exercise,
or other lifestyle) that might be made to avoid certain undesirable
predicted outcomes, and the system can predict their respective
effects.
[0320] Many apps are downloaded to users' phones, and left un-used
after a week or so. In part, this is due to the hurdle of having to
awaken the phone from sleep mode whenever use of the app is
desired. Technologies are arising, however, (such as applicant's
patent application 61/920,722, filed Dec. 24, 2013) in which
portable user devices can maintain some functionality--such as
audio responsiveness--even when "asleep." (In some embodiments,
this capability relies on use of an auxiliary processor that is
active all the time, and which consumes just a tiny fraction of the
power consumed by the phone's primary processor(s).)
[0321] In accordance with another aspect of the technology, the
audio and/or other physiologic signal sensing described herein is
on-going even when the screen of the device is dark and the device
is otherwise in a "sleep" mode. To reduce battery drain, the data
collected in this mode is not streamed to the cloud, but rather is
cached in a memory until the phone is next awakened. Similarly, the
processing of the captured data to produce derivative data may be
queued, e.g., waiting until the device's primary processor is again
available. Thus, data collection aspects of a health app may be
on-going, 24 hours a day, 7 days a week.
[0322] As noted, individual privacy is a concern with such
technologies. Yet, so too is the importance of establishing a pool
of shared information that is sufficiently large to bring benefits
of scale and meaningful statistics. Users may sometimes serve as
providers of their own information, and consumers of others'
information. In such situation, there can be a marketplace for
exchange of physiologic information. Those whose consumption is out
of proportion to their sharing may be called on to pay, or offer
other consideration, for their relatively high consumption (or, put
another way, for their relatively heightened privacy). Those who
share more than they consume may receive cash or other
consideration to reward their relative openness. The marketplace
can establish the equilibrium point between giving and taking,
where no exchange of consideration is required.
[0323] (Some categories of information, e.g., carotid artery
sounds, may be scarcer than others. Similarly, information from
certain demographic segments, e.g., young women in North Dakota,
may be scarcer than others. The exchange marketplace can take such
factors into account in establishing pricing for information.)
[0324] In some arrangements, a person's consultation with a
physician may not be prompted by use of the present technology;
rather, a consultation with a physician may prompt use of the
present technology.
[0325] For example, a patient may visit a physician prompted by an
onset of wheezing in their respiration. On investigation, the
physician may detect a murmur (which may be associated with the
wheezing). The physician may instruct the patient to capture,
twice-daily, sounds of the murmur by positioning the phone in a
certain location on the chest. Such in-home data collection can
then inform judgments by the physician about further care.
[0326] Similarly, a physician who diagnoses possible depression in
a patient can use voice data from at-home data collection to
determine whether the condition is trending better or worse. (The
physician needn't review the actual recorded voice. Parameters
expressing volume, pitch, and variations in same, can be derived
from the patient's sensed voice, and succinctly reported for
physician review.)
[0327] A hundred years ago, physicians didn't have labs that could
analyze a bit of body fluid to produce a page full of quantitative
data; they relied on their eyes, and ears, and their fingers. Lab
data gives great insight into patient conditions, but something is
lost when lab analysis replaces physical exam--as often now seems
to be the case. Applications of the present technology redress this
shortcoming, employing digital sensors that are more acute and
accurate than any physician's senses. Coupled with insights from
Big Data, digital sensor-assisted physical exam may again emerge as
the primary tool of diagnostic medicine.
[0328] (As noted elsewhere--but it bears repeating, it is poor
practice to make an automated diagnosis based on sensed data and
statistics. But such information allows systems according to the
present technology to conclude that something seems different or
amiss, so that such fact can be revealed and acted on by a
professional.)
Review
[0329] A very few of the novel arrangements detailed herein are
reviewed in rough summary fashion, below.
[0330] One aspect of the present technology involves collecting
physiologic information in a data structure, where the collected
information corresponds to physiologic sensor data gathered by
plural non-professional users. In the data structure is also
collected professional evaluation information corresponding to at
least some of the physiologic information. Thereafter, query
information is received, corresponding to physiologic sensor data
gathered by a non-professional user. The data structure is
consulted in determining result information, and at least some of
this result information is communicated to the non-professional
user. This result information depends on correlation between the
query information, the collected physiology information, and the
professional evaluation information.
[0331] Another arrangement employs a portable device that is moved
to plural different viewpoint positions relative to a skin
location. At a first of these viewpoint positions, the skin
location is illuminated with light of a first spectrum from the
portable device. While so-illuminated, imagery of the skin location
is captured using a camera in the portable device. At a second of
these viewpoint positions, the skin location is illuminated with
light of a second spectrum from the portable device. Again, while
so-illuminated, imagery of the skin location is captured using the
portable device. Thus, the skin location is imaged by the portable
device from plural different viewpoint positions and with plural
different illumination spectra. The captured imagery may then be
processed and, based on such processing, the user may be advised
whether to seek a professional evaluation of the skin location.
[0332] In a related method, the skin location is illuminated with
light of a first spectrum from a first region of a display of the
portable device, while imagery of the skin location is captured.
Similarly, the skin location is illuminated with light of a second
spectrum from a second region of the portable device display.
Again, imagery of the skin location is captured while illuminated
with this second spectrum of light. By such arrangement, imagery of
the skin location is captured with plural different illumination
angles and plural different illumination spectra.
[0333] Still another related method involves presenting a first
illumination from a portable device display screen to a subject at
a first time, and capturing a first image of the subject when it is
so-illuminated. Likewise, second illumination is presented from the
display screen to the subject at a second time, and a second image
of the subject, so-illuminated, is captured. In such arrangement,
the illumination does not comprise a viewfinder rendering of
captured imagery.
[0334] Another aspect of the technology involves capturing image
information from a reference subject, using a camera, and
processing the captured image information to yield reference color
information. Imagery is also captured with the camera, depicting a
skin rash or lesion. This latter imagery is then color-corrected by
use of the reference color information. (The reference subject can
comprise, e.g., blood or a banknote.)
[0335] Still another aspect of the technology involves receiving
imagery comprising plural frames depicting a skin rash or lesion. A
processing operation is invoked on the plural frames, to yield an
enhanced still image (e.g., (a) a super-resolution image, (b) a
noise-reduced image, (c) a multi-spectral image, (d) an ambient
light-compensated image, or (e) a 3D image). The enhanced still
image (or data derived therefrom) is submitted to a database for
similarity-matching with reference images depicting skin rashes or
lesions, or data derived from such reference images. Such database
includes reference data corresponding to enhanced still images that
themselves have been processed from plural-frame imagery.
[0336] Yet another arrangement according to the present technology
involves obtaining plural sets of professional data, where each set
includes skin image data and patient profile data. This patient
profile data includes both opinion information provided by a
medical professional, and factual information. From the skin image
data, first feature information is extracted (e.g., using a
hardware processor configured to perform such act). Plural sets of
lay data are also obtained, where this lay data includes skin image
data and patient profile data (e.g., fact data), but lacks
information provided by a medical professional. From the skin image
data in the lay data, second feature information is extracted. The
first and second extracted feature information is then made
available as reference feature information for similarity-matching
with feature information extracted from query skin image data.
[0337] Still another aspect of the technology involves receiving
data, including skin image data and associated metadata, from a
party. Similarities between the received data and reference data
are determined. This reference data includes multiple sets of data,
each including skin image data and associated metadata. Included
among the reference data are sets of data that have been
professionally curated, and also sets of data that have not been
professionally curated.
[0338] A further method involves receiving a first set of
information from a first submitter, where the first set of
information includes imagery depicting a part of a first subject's
body that evidences a symptom of a first pathological condition,
and also includes drug profile data indicating drugs taken by the
first subject. A second set of information is received from a
second submitter. This second set of information includes imagery
depicting a part of a second subject's body that evidences a
symptom of a second pathological condition, and also includes drug
profile data indicating drugs taken by the second subject. Such
sets of information are received from 3d through Nth submitters.
Information is then received corresponding to a query image
submitted by a user. One or more image parameters are computed from
this query image, and compared for correspondence against such
parameters computed for the imagery received from the first through
Nth submitters. Information is then sent to the user, identifying
one or more drugs that is correlated with skin imagery (e.g., skin
symptoms) having an appearance like that in the query image.
[0339] Yet another method involves receiving a first set of
information from a first submitter, where this first set of
information includes imagery depicting a part of a first subject's
body that evidences a symptom of a first pathological condition,
and also includes a diagnosis of the first pathological condition.
Such information is likewise received from a second submitter,
including imagery depicting part of a second subject's body that
evidences a symptom of a second pathological condition, and also
includes a diagnosis of the second pathological condition. This is
repeated for third through Nth sets of information, received from
third through Nth submitters. Information is then received
corresponding to a query image submitted by a user. One or more
parameters are computed from the query image. A search is conducted
to identify imagery received from the first through Nth submitters
having correspondence with the computed image parameter(s).
Information (e.g., information about candidate diagnoses, or about
diagnoses that are inconsistent with the available information) are
then sent to the user, based on such searching of imagery.
[0340] Still another method involves obtaining first imagery
depicting a part of a mammalian body that evidences a symptom of a
possible pathological condition. This imagery is processed to
derive one or more image parameter(s). A data structure is searched
for reference information, based on the derived image parameter(s).
Result information is determined as a consequence of such search.
This reference information comprises information identifying one or
more particular pathological conditions that is not the
pathological condition evidenced by the depicted part of the body.
At least some of this result information is communication to a
user.
[0341] A further aspect of the technology involves sensing whether
a mobile device is in a static, viewing pose. When it is not,
frames of imagery depicting a user are collected. When it is in the
static viewing pose, information is presented for user review. This
presented information is based, at least in part, on the collected
frames of imagery. In such arrangement, the mobile device
automatically switches between data collection and data
presentation modes (e.g., based on pose and/or motion).
[0342] A further aspect of the technology involves capturing audio
sounds from a user's body, using a portable device held by the
user. Plural features are derived from the captured audio; these
features comprise fingerprint information corresponding to the
captured sounds. This fingerprint information is provided to a
knowledge base (data structure), which contains reference
fingerprint data and associated metadata. Metadata associated with
one or more of the reference fingerprint data in the knowledge base
is then received back by the device. Information based on this
received metadata (e.g., physiologic- or health-related
information) is presented to the user.
[0343] Still another aspect of the present technology concerns an
imaging booth defined by one or more sidewalls. A plurality of
cameras are disposed along the one or more side walls, directed
toward an interior of the booth, and these cameras are connected to
an image processor. The booth also includes a plurality of light
sources directed toward the interior of the booth, coupled to
driving electronics. Plural of these light sources is each
spectrally tuned to a different wavelength, and the driving
electronics are adapted so that different of the lighting elements
illuminate at different times, causing the cameras to capture
imagery under plural different spectral lighting conditions. The
image processor is adapted to produce spectricity measurements
based on imagery from the cameras.
CONCLUDING REMARKS
[0344] Having described and illustrated the principles of the
inventive work with reference to illustrative examples, it will be
recognized that the technology is not so limited.
[0345] For example, medical diagnosis often relies heavily on
patient history. Such history information can be extracted from
medical records, and used in assessing the possible diagnostic
relevance of different physiologic signals, or combinations of
signals.
[0346] To illustrate, crackles or rales in the lungs, for most
people, may indicate pneumonia--even if accompanied by a gain in
weight. However, if these symptoms appear in a person known to be
suffering from chronic heart failure, then the lung sounds take on
a new significance--one that requires a prompt visit to the
doctor.
[0347] Likewise, DNA testing is becoming more commonplace. A
physiologic signal (e.g., crackles or rales) may take on new
meaning when interpreted in the context of particular DNA findings
(which may indicate, e.g., a susceptibility to particular viral
illnesses).
[0348] Although the focus of this disclosure has been on capture of
imagery, audio, and more familiar physiologic data, mention should
also be made of haptics. Haptic technology allows data to be
acquired concerning tactile information--such as the firmness,
tautness, elasticity or resilience of a body part. (See, e.g.,
Murayama, et al, Development of a New Instrument for Examination of
Stiffness in the Breast Using Haptic Sensor Technology, Sensors and
Actuators A: Physical 143.2, pp. 430-438, 2008.) In addition to
haptic sensors, haptic actuators can also be employed--applying
physical forces to the body in controlled direction, strength, and
temporal pattern, so that measurement data responsive to such
stimulus can be sensed. Again, by collection of a body of haptic
information, and correlation with physicians' diagnostic ground
truth, certain haptic data (or its derivatives) can be discovered
to have diagnostic significance.
[0349] While the Face-Chek mode noted above employed rainbow mode
illumination, it will be recognized that the Face-Chek mode can
also use other lighting arrangements, e.g., simple ambient
light.
[0350] Certain of the described arrangements may capture imagery in
which the body of the camera device (e.g., smartphone) casts a
visible shadow. Arrangements for detailing with such shadows are
detailed in applicant's U.S. Pat. No. 8,488,900.
[0351] While one of the above-detailed dermatological embodiments
employed a brute force, exhaustive search through a knowledge base
to assess similarities with reference image data, more
sophisticated methods can naturally be employed.
[0352] One is to provide indices to the database, sorted by
different parameters. Thus in the case of a simple scalar parameter
that ranges from 0-100, if the query image has a parameter of 37,
then a binary or other optimized search can be conducted in the
index to quickly identify reference images with similar parameter
values. Reference images with remote values needn't be considered
for this parameter. (Most of the detailed image derivatives are
vector parameters, comprising multiple components. Similar database
optimization methods can be applied.)
[0353] Still further, known machine learning techniques can be
applied to the reference data to discern which image derivatives
are most useful as diagnostic discriminants of different
conditions. When a query image is received, it can be tested for
these discriminant parameters to more quickly perform a Bayesian
evaluation of different candidate diagnosis hypotheses.
[0354] Bag-of-features techniques (sometimes termed "bag of words"
techniques) can also be mployed to ease, somewhat, the image
matching operation (but such techniques "cheat" by resort to data
quantization that may--in some instances--bias the results).
[0355] Other pattern recognition techniques developed for automated
mole diagnosis can likewise be adapted to identifying database
images that are similar to a query image.
[0356] Certain embodiments of the present technology can employ
existing online catalogs of imagery depicting different
dermatological symptoms and associated diagnoses. Examples include
DermAtlas, at www<dot>dermatlas<dot>org--a
crowd-sourced effort managed by physicians at Johns Hopkins
University) and DermNet NZ at
www<dot>dermnetnz<dot>org--a similar effort by the New
Zealand Dermatological Society. Similarly-named to the latter is
Dermnet, a skin disease atlas organized by a physician in New
Hampshire, based on submittals from various academic institutions,
www<dot>dermnet<dot>com. Also related is the website
Differential Diagnosis in Dermatology,
www<dot>dderm<dot>blogspot<dot>com, and the web
site of the International Dermoscopy Society,
www<dot>dermoscopy-ids<dot>org.
[0357] Sometimes patient privacy rights (e.g., HIPAA) pose an
impediment to collection of imagery, even for anonymous,
crowd-source applications. As suggested above, one approach to
collection of crowd-sourced imagery is to offer financial
incentives to patients to induce them to share their mole imagery
or other physiologic information.
[0358] While one of the detailed arrangements presented a ranked
listing of possible pathologies to consider (or to rule out), other
embodiments can present information otherwise, e.g., with other
representations of confidence. Histograms, heat maps, and
phylogenetic diagrams are examples.
[0359] In some embodiments, the technology serves as an advisor to
a medical professional--offering suggested diagnoses, or further
testing, to consider. The offered advice may be tailored in
accordance with wishes of the professional, e.g., expressed in
stored profile data corresponding to that professional. For
example, one practitioner may express a conservative medical
philosophy, in which case such an advisory service may offer only
observations/suggestions in which there is a high degree of
confidence. Conversely, another practitioner may be more open to
novel theories and approaches, in which case the system may also
present candidate diagnoses (and further testing suggestions) that
is more speculative.
[0360] Similarly, some practitioners may specify diagnostic
criteria that they tend to weigh more (or less) heavily in reaching
particular conclusions. In dermatology, for instance, one physician
may regard chromatic diversity across a mole as particularly
relevant to a diagnosis of malignant melanoma. Another physician
may not hold such criterion in high regard, but may find scalloped
edge contours to be highly probative for such a diagnosis. Again,
stored profile data for the different professionals can indicate
such preferences, and tailor system response accordingly. (In some
arrangements, such preferences are not expressly specified as
profile information by the physician, but rather are deduced
through analysis of electronic medical records detailing previous
diagnoses, and the clinical data on which they were based.)
[0361] In processing imagery, e.g., of moles, known photogrammetry
techniques are desirably employed to mitigate for pose distortion
and camera optics, to yield an orthorectified image (aka an
orthoimage). So doing enhances the statistical matching of
user-submitted skin imagery with previously-submitted imagery.
[0362] While the skin conditions discussed above are organic in
nature, the same principles can be applied to skin conditions that
result from trauma, including bug bites and wounds. A user who
returns from a vacation with a painful leg bite may wonder: Is it a
spider bite? A flea? A bed bug? A scrape that doesn't heal well,
and turns red and angry, may be another cause for concern: Is that
a staph infection? As in the cases detailed above, a suitably-large
knowledge base can reveal answers.
[0363] Reference was made to sensed information, and other
information derived therefrom. This latter information is variously
referred to in this specification, e.g., as features, parameters,
fingerprints, derived data, etc. It should be understood that these
latter terms are interchangeable.
[0364] Another form of metadata that may be associated with sensed
user data (e.g., skin images) is information indicating treatments
the user has tried, and their assessment of success (e.g., on a
0-10 scale). In the aggregate, such data may reveal effective
treatments for different types of rashes, acne, etc.
[0365] Skin also serves as a barometer of other conditions,
including emotion. Each emotion activates a different collection of
bodily systems, triggering a variety of bodily responses, e.g.,
increased blood flow (vasocongestion) to different regions,
sometimes in distinctive patterns that can be sensed to infer
emotion. (See, e.g., Nummenmaa, et al, Bodily Maps of Emotions,
Proceedings of the National Academy of Sciences of the United
States of America, 111, pp. 646-651, 2014.) Just as skin
conductivity is used in some lie detectors, so too may skin
imagery.
[0366] In some systems, sensed physiologic information and its
derivatives are represented in the form of Linked Data--both for
individual and aggregate data, and both for storage and for
sharing--in order to facilitate semantic reasoning with such
information. (The artisan is presumed to be familiar with Linked
Data and related constructs, e.g., as popularized by Tim
Berners-Lee, as standardized by the World Wide Web Consortium, and
as discussed in the assignee's patent publications including
20110098056 and 20120154633.)
[0367] In other embodiments, imagery, image derivatives, and
metadata information are stored in accordance with the DICOM
standards for medical image records (see, e.g.,
www<dot>dclunie<dot>com/dicom-status/status<dot>html).
[0368] Certain embodiments of the technology recognize the user's
forearm or other body member (e.g., by classification methods), and
use this information in later processing (e.g., in assessing scale
of skin features). In some such arrangements, analysis is applied
to video information captured while the user is moving the
smartphone camera into position to capture skin imagery. Such
"flyover" video is commonly of lower resolution, and may suffer
from some blurring, but is adequate for body member-recognition
purposes. If, e.g., a hand is recognized from one or more frames of
such video, and the smartphone is thereafter moved (as sensed by
accelerometers and/or gyroscopes) in a manner consistent with that
hand being the ultimate target for imaging (e.g., the smartphone is
moved in a direction perpendicular to the plane of the phone
screen--moving it closer to the hand), then the subject of the
image is known to be the hand, even if the captured diagnostic
image itself is a close-up from which the body location cannot be
deduced.
[0369] Many of the techniques described in connection with humans
can also be applied to animals. Unusual skin conditions can be
expanded to animal hide, fur and feathers (although false positives
and hidden conditions may be more likely with complex skin
coverings). Vets often face a more difficult challenge than
physicians, since animals cannot describe symptoms that might aid
in diagnosis, making the notion of providing a candidate list of
maladies and being able to quickly test for additional symptoms
even more valuable. Pet owners often need to decide whether
symptoms warrant a visit to a vet and whether particular visible
symptoms can be explained by recent known activities of that pet.
Furthermore, livestock owners face the challenge of outbreaks of
contagious diseases and need to inspect their animals often to
catch such diseases as early as possible. Pet and livestock owners
can benefit greatly from the present technology for examining and
diagnosing conditions.
[0370] For livestock owners, an automated early warning system can
be set in place where livestock passing through gates or paddocks
are routinely examined for unusual skin variations that suggest
closer examination is needed. Livestock are often outfitted with RF
tags for identification, allowing such a monitoring system to
compare individual livestock over time to rule out health
conditions that have already been addressed, and to note new,
emerging conditions. Wildlife managers can also benefit by setting
up imaging systems on commonly traversed paths that are triggered
by passing animals. Again, early detection and identification of
contagious conditions or dangerous pests is key to maintaining
healthy populations.
[0371] Another diagnostically useful feature is temporal
observation of blood flow through the area of a skin condition.
Subtle color changes due to local blood pressure modulated by
heartbeats can be used to distinguish between, or assess the
severity of, some skin conditions. One method of observing these
subtle color changes is given in the Wu paper cited below
("Eulerian Video Magnification for Revealing Subtle Changes in the
World"), where small differences are magnified through
spatio-temporal signal processing. Elasticity of a region can be
measured by applying pressure (by machine or by touch) in such a
way as to bend the skin. By comparing various points on the skin
before and after deformation (ideally, a repeated pattern of
deformation to allow for averaging), the local elastic properties
of the skin can be included in the diagnosis.
[0372] While 3D considerations were noted above (e.g., in regard to
structure-from-motion methods), the local 3D texture of the skin
condition region can also be assessed through the use of 3D imaging
technology, including light-field and plenoptic cameras. One can
consider both the angle of illumination of the incident light with
respect to the imaging sensor as well as a lens cluster that
provides depth variations as a byproduct of the imaging method.
[0373] Image analysis in the Lab color space is often preferred to
RGB-based analysis, since normal skin color is a relatively small
region in (a,b). The value of L (luminance) depends on the
concentration of melanin, the skin color dye.
[0374] Reference was made to surface topology, and methods
regarding same. Accurate 3D information can also obtained from a
single camera system by illuminating a region of interest of the
patient with a structured light pattern. Distortions in the
structured light pattern are used to determine the 3D structure of
the region, in familiar manner. The pattern may be projected, e.g.,
by a projector associated with the camera system. (E.g., a mobile
phone or headworn apparatus can include a pico data projector.)
[0375] Another group of image processing techniques useful in
diagnostic analyses is Mathematical Morphology (see, e.g., the
Wikipedia article of that name), where the topology of an image is
described in terms of spatial surface descriptions. This is used,
e.g., in counting of small creatures/structures under a microscope.
Such technology is well suited to counting "bumps" or other
structures per area in a skin lesion. It also allows for
representation by attributed relational graphs that describe a
detailed relationship between structures that can be compared as
graphs independent of orientation and specific configuration.
[0376] It will be recognized that the term "lesion" is used in this
specification in a generic sense, e.g., referring to any feature of
the skin, including spots, moles, rashes, nevi, etc.
[0377] While reference was made to app software on a user's
smartphone as performing certain of the detailed functionality, in
other embodiments these functions can naturally be performed
otherwise--including by operating system software on a smartphone,
by a remote server, by another smartphone or computer device,
distributed between such devices, etc.
[0378] While reference has been made to smartphones, it will be
recognized that this technology finds utility with all manner of
devices--both portable and fixed. Tablets, laptop computers,
digital cameras, wrist- and head-mounted systems and other wearable
devices, servers, etc., can all make use of the principles detailed
herein. (The term "smartphone" should be construed herein to
encompass all such devices, even those that are not
telephones.)
[0379] Reference was made to "bag of features" techniques. Such
methods extract local features from patches of an image (e.g., SIFT
points), and automatically cluster the features into N groups
(e.g., 168 groups)--each corresponding to a prototypical local
feature. A vector of occurrence counts of each of the groups (i.e.,
a histogram) is then determined, and serves as a reference
signature for the image, or for a sub-part thereof. To determine if
a query image matches the reference image, local features are again
extracted from patches of the image, and assigned to one of the
earlier-defined N-groups (e.g., based on a distance measure from
the corresponding prototypical local features). A vector occurrence
count is again made, and checked for correlation with the reference
signature. Further information is detailed, e.g., in Nowak, et al,
Sampling strategies for bag-of-features image classification,
Computer Vision-ECCV 2006, Springer Berlin Heidelberg, pp. 490-503;
and Fei-Fei et al, A Bayesian Hierarchical Model for Learning
Natural Scene Categories, IEEE Conference on Computer Vision and
Pattern Recognition, 2005; and references cited in such papers.
[0380] Some of applicant's related work, e.g., concerning imaging,
image processing systems, and related smartphone apps is detailed
in patent publications 20110212717, 20110161076, 20120284012,
20120046071, 20140052555, 20130329006, 20140057676, and in pending
application Ser. No. 13/842,282, filed Mar. 15, 2013, Ser. No.
14/251,229, filed Apr. 11, 2014, 61/861,931, filed Aug. 2, 2013,
and Ser. No. 13/969,422, filed Aug. 16, 2013.
[0381] Several references have been made to application Ser. No.
14/201,852. In addition to extensive disclosure of several
multi-spectral imaging techniques, that document teaches a variety
of other arrangements that are useful in conjunction with the
present technology. These include techniques for mitigating errors
in spectricity measurements, compensation for field angle
non-uniformities, various classification methods (including vector
quantization, support vector machines, and neural network
techniques), different object recognition technologies, and image
comparison based on the freckle transform data, among others.
[0382] SIFT is an acronym for Scale-Invariant Feature Transform, a
computer vision technology pioneered by David Lowe and described in
various of his papers including "Distinctive Image Features from
Scale-Invariant Keypoints," International Journal of Computer
Vision, 60, 2 (2004), pp. 91-110; and "Object Recognition from
Local Scale-Invariant Features," International Conference on
Computer Vision, Corfu, Greece (September 1999), pp. 1150-1157, as
well as in U.S. Pat. No. 6,711,293. Additional information about
SIFT (and similar techniques SURF and ORB) is provided in the
patent documents cited herein.
[0383] While SIFT is referenced, other robust feature points may be
preferred for skin imagery. For example, SIFT is typically
performed on grey-scale imagery; color is ignored. In contrast,
feature points for skin can advantageously employ color. An
exemplary set of feature points specific to close-up skin imagery
can comprise skin pores (or hair follicles). The center of mass of
each such feature is determined, and the pixel coordinates of each
are then associated with the feature in a data structure. In other
arrangements, 3D features can additionally or alternatively be
used. Features can also be drawn from those that are revealed by
infrared sensing, e.g., features in the dermal layer, including
blood vessel minutiae. (See, e.g., Seal, et al, Automated Thermal
Face Recognition Based on Minutiae Extraction, Int. J.
Computational Intelligence Studies, 2013, 2, 133-156, attached to
application 61/872,494, and references cited therein.)
[0384] The design of smartphones and other such devices reference
herein is familiar to the artisan. In general terms, each includes
one or more processors, one or more memories (e.g. RAM), storage
(e.g., a disk or flash memory), a user interface (which may
include, e.g., a keypad, a TFT LCD or OLED display screen, touch or
other gesture sensors, a camera or other optical sensor, a compass
sensor, a 3D magnetometer, a 3-axis accelerometer, a 3-axis
gyroscope, one or more microphones, etc., together with software
instructions for providing a graphical user interface),
interconnections between these elements (e.g., buses), and an
interface for communicating with other devices (which may be
wireless, such as GSM, 3G, 4G, CDMA, WiFi, WiMax, Zigbee or
Bluetooth, and/or wired, such as through an Ethernet local area
network, a T-1 internet connection, etc.).
[0385] The processes and system components detailed in this
specification can be implemented as instructions for computing
devices, including general purpose processor instructions for a
variety of programmable processors, including microprocessors
(e.g., the Intel Atom, the ARM A5, and the Qualcomm Snapdragon, and
the nVidia Tegra 4; the latter includes a CPU, a GPU, and nVidia's
Chimera computational photography architecture), graphics
processing units (GPUs, such as the nVidia Tegra APX 2600, and the
Adreno 330-part of the Qualcomm Snapdragon processor), and digital
signal processors (e.g., the Texas Instruments TMS320 and OMAP
series devices), etc. These instructions may be implemented as
software, firmware, etc. These instructions can also be implemented
in various forms of processor circuitry, including programmable
logic devices, field programmable gate arrays (e.g., the Xilinx
Virtex series devices), field programmable object arrays, and
application specific circuits--including digital, analog and mixed
analog/digital circuitry. Execution of the instructions can be
distributed among processors and/or made parallel across processors
within a device or across a network of devices. Processing of
signal data may also be distributed among different processor and
memory devices. "Cloud" computing resources can be used as well.
References to "processors," "modules" or "components" should be
understood to refer to functionality, rather than requiring a
particular form of implementation.
[0386] Software instructions for implementing the detailed
functionality can be authored by artisans without undue
experimentation from the descriptions provided herein, e.g.,
written in C, C++, Visual Basic, Java, Python, Tcl, Perl, Scheme,
Ruby, etc. Smartphones and other devices according to certain
implementations of the present technology can include software
modules for performing the different functions and acts.
[0387] Software and hardware configuration data/instructions are
commonly stored as instructions in one or more data structures
conveyed by tangible media, such as magnetic or optical discs,
memory cards, ROM, etc., which may be accessed across a network.
Some embodiments may be implemented as embedded systems--special
purpose computer systems in which operating system software and
application software are indistinguishable to the user (e.g., as is
commonly the case in basic cell phones). The functionality detailed
in this specification can be implemented in operating system
software, application software and/or as embedded system
software.
[0388] The databases and other data structures referenced herein
can be monolithic, or can be distributed. Thus, reference data may
be stored anywhere, e.g., user devices, remote device, in the
cloud, divided between plural locations, etc.
[0389] While the specification described certain acts as being
performed by the user device (phone) or by the central system, it
will be recognized that any processor can usually perform any
function. For example, computation of image derivatives, and color
correction, can be done by the user's smartphone or by the central
system--or distributed between various devices. Thus, the fact that
an operation is described as being performed by one apparatus,
should be understood as exemplary and not limiting.
[0390] In like fashion, description of data being stored on a
particular device is also exemplary; data can be stored anywhere:
local device, remote device, in the cloud, distributed, etc.
[0391] As indicated, the present technology can be used in
connection with wearable computing systems, including headworn
devices. Such devices typically include one or more sensors (e.g.,
microphone(s), camera(s), accelerometers(s), etc.), and display
technology by which computer information can be viewed by the
user--either overlaid on the scene in front of the user (sometimes
termed augmented reality), or blocking that scene (sometimes termed
virtual reality), or simply in the user's peripheral vision. A
headworn device may further include sensors for detecting
electrical or magnetic activity from or near the face and scalp,
such as EEG and EMG, and myoelectric signals--sometimes termed
Brain Computer Interfaces, or BCIs. (A simple example of a BCI is
the Mindwave Mobile product by NeuroSky, Inc.) Exemplary wearable
technology is detailed in patent documents 7,397,607, 20100045869,
20090322671, 20090244097 and 20050195128. Commercial offerings, in
addition to the Google Glass product, include the Vuzix Smart
Glasses M100, Wrap 1200AR, and Star 1200XL systems. An upcoming
alternative is augmented reality contact lenses. Such technology is
detailed, e.g., in patent document 20090189830 and in Parviz,
Augmented Reality in a Contact Lens, IEEE Spectrum, September,
2009. Some or all such devices may communicate, e.g., wirelessly,
with other computing devices (carried by the user or otherwise), or
they can include self-contained processing capability. Likewise,
they may incorporate other features known from existing smart
phones and patent documents, including electronic compass,
accelerometers, gyroscopes, camera(s), projector(s), GPS, etc.
[0392] As noted, embodiments of present technology can also employ
neuromorphic processing techniques (sometimes termed "machine
learning," "deep learning," or "neural network technology"). As is
familiar to artisans, such techniques employ large arrays of
artificial neurons--interconnected to mimic biological synapses.
These methods employ programming that is different than the
traditional, von Neumann, model. In particular, connections between
the circuit elements are weighted according to correlations in data
that the processor has previously learned (or been taught).
[0393] Each artificial neuron, whether physically implemented or
simulated in a computer program, receives a plurality of inputs and
produces a single output which is calculated using a nonlinear
activation function (such as the hyperbolic tangent) of a weighted
sum of the neuron's inputs. The neurons within an artificial neural
network (ANN) are interconnected in a topology chosen by the
designer for the specific application. In one common topology,
known as a feed-forward network, the ANN consists of an ordered
sequence of layers, each containing a plurality of neurons. The
neurons in the first, or input, layer have their inputs connected
to the problem data, which can consist of image or other sensor
data, or processed versions of such data. Outputs of the first
layer are connected to the inputs of the second layer, with each
first layer neuron's output normally connected to a plurality of
neurons in the second layer. This pattern repeats, with the outputs
of one layer connected to the inputs of the next layer. The final,
or output, layer produces the ANN output. A common application of
ANNs is classification of the input signal into one of N classes
(e.g., classifying a type of mole). In this case the output layer
may consist of N neurons in one-to-one correspondence with the
classes to be identified. Feed-forward ANNs are commonly used, but
feedback arrangements are also possible, where the output of one
layer is connected to the same or to previous layers.
[0394] Associated with each connection within the ANN is a weight,
which is used by the input neuron in calculating the weighted sum
of its inputs. The learning (or training) process is embodied in
these weights, which are not chosen directly by the ANN designer,
In general, this learning process involves determining the set of
connection weights in the network that optimizes the output of the
ANN is some respect. Two main types of learning, supervised and
unsupervised, involve using a training algorithm to repeatedly
present input data from a training set to the ANN and adjust the
connection weights accordingly. In supervised learning, the
training set includes the desired ANN outputs corresponding to each
input data instance, while training sets for unsupervised learning
contain only input data. In a third type of learning, called
reinforcement learning, the ANN adapts on-line as it is used in an
application. Combinations of learning types can be used; in
feed-forward ANNs, a popular approach is to first use unsupervised
learning for the input and interior layers and then use supervised
learning to train the weights in the output layer.
[0395] When a pattern of multi-dimensional data is applied to the
input of a trained ANN, each neuron of the input layer processes a
different weighted sum of the input data. Correspondingly, certain
neurons within the input layer may spike (with a high output
level), while others may remain relatively idle. This processed
version of the input signal propagates similarly through the rest
of the network, with the activity level of internal neurons of the
network dependent on the weighted activity levels of predecessor
neurons. Finally, the output neurons present activity levels
indicative of the task the ANN was trained for, e.g. pattern
recognition. Artisans will be familiar with the tradeoffs
associated with different ANN topologies, types of learning, and
specific learning algorithms, and can apply these tradeoffs to the
present technology.
[0396] Another machine learning arrangement that is well suited for
embodiments of the present technology is support vector machines
(SVMs). SVMs are detailed, e.g., in U.S. Pat. Nos. 6,157,921,
6,714,925, 7,797,257 and 8,543,519.
[0397] Additional information on such techniques is detailed in the
Wikipedia articles on "Machine Learning," "Deep Learning," and
"Neural Network Technology," as well as in Le et al, Building
High-Level Features Using Large Scale Unsupervised Learning, arXiv
preprint arXiv:1112.6209 (2011), and Coates et al, Deep Learning
with COTS HPC Systems, Proceedings of the 30th International
Conference on Machine Learning (ICML-13), 2013. These journal
papers, and then-current versions of the "Machine Learning" and
"Neural Network Technology" articles, are attached as appendices to
copending patent application 61/861,931, filed Aug. 2, 2013.
application Ser. No. 14/201,852 also has a discussion of machine
learning useful with the present technology.
[0398] Reference was made to statistical findings based on the
reference data. The artisan is presumed to be familiar with
statistics and their use.
[0399] In some of the foregoing examples, reference was made to a
condition being statistically unlikely or improbable. The
particular threshold used in such determinations can be set by the
implementer, based on the requirements of the particular
application. In some arrangements, a probability of less than 1%
may be deemed statistically unlikely. In others, a probability of
less than 0.3%, 0.1%, 0.03% or 0.01% may be required.
[0400] Pulse detection from wearable clothing and devices is
taught, e.g., in U.S. Pat. Nos. 5,622,180, 6,104,947 and U.S. Pat.
No. 7,324,841 to Polar Electro OY. Other related writings include
patent documents U.S. Pat. Nos. 6,021,344, 6,606,628, 6,882,990,
7,233,693, 20020021828, 20080194928, 20110301441, 2012008838,
20120308086, and WO13070895, and the following other publications
(all appended to application 61/832,715): [0401] Arafini,
"Dermatological disease diagnosis using color-skin images," 2012
Intl Conf on Machine Learning and Cybernetics; [0402] Bersha,
"Spectral Imaging and Analysis of Human Skin," Master's Thesis,
University of Eastern Finland, 2010; [0403] Cavalcanti, et al, "An
ICA-based method for the segmentation of pigmented skin lesions in
macroscopic images, IEEE Int'l Conf on Engineering in Medicine and
Biology Society, 2011; [0404] Cavalcanti, et al, Macroscopic
pigmented skin lesion segmentation and its influence on lesion
classification and diagnosis, Color Medical Image Analysis.
Springer Netherlands, 2013, pp. 15-39; [0405] Korotkov et al,
"Computerized analysis of pigmented skin lesions--a review,"
Artificial Intelligence in Medicine 56, pp. 69-90 (2012); [0406]
Parolin, et al, "Semi-automated diagnosis of melanoma through the
analysis of dermatological images," 2010 23rd IEEE SIBGRAPI
Conference on Graphics, Patterns and Images; [0407] Sadeghi et al,
"Detection and analysis of irregular streams in dermoscopic images
of skin lesions," preprint, IEEE Trans. on Medical Imaging, 2013;
[0408] Sadeghi, et al, "Automated Detection and Analysis of
Dermoscopic Structures on Dermoscopy Images," 22nd World Congress
of Dermatology, 2011; and [0409] Wu, Eulerian Video Magnification
for Revealing Subtle Changes in the World, ACM Transactions on
Graphics, Vol. 31, No. 4 (2012) p 65 (8 pp.).
[0410] Other related writings include the following, each appended
to application 61/872,494: [0411] Abbas, et al, Hair Removal
Methods: a Comparative Study for Dermoscopy Images, Biomedical
Signal Processing and Control 6.4, 2011, pp. 395-404; [0412]
Armstrong et al, Crowdsourcing for Research Data Collection in
Rosacea, Dermatology Online Journal, Vol. 18, No. 3, March, 2012;
[0413] Baeg et al, Organic Light Detectors--Photodiodes and
Phototransistors Advanced Materials, Volume 25, Issue 31, Aug. 21,
2013; [0414] Bellazzi, et al, Predictive Data Mining in Clinical
Medicine--Current Issues and Guidelines, Int'l J. of Medical
Informatics, V. 77, 2008, pp. 81-97; [0415] BioGames--A Platform
for Crowd-Sourced Biomedical Image Analysis and Telediagnosis,
Games Health, Oct. 1, 2012, pp. 373-376; [0416] Cruz, et al,
Applications of Machine Learning in Cancer Prediction and
Prognosis, Cancer Infom., No. 2, 2006, pp. 59-77; [0417] Csurka, et
al, Visual Categorization with Bags of Keypoints, ECCV, Workshop on
Statistical Learning in Computer Vision, 2004; [0418] Dalal, et al,
Histograms of Oriented Gradients for Human Detection, IEEE
Conference on Computer Vision and Pattern Recognition, pp. 886-893,
2005; [0419] di Leo, Automatic Diagnosis of Melanoma: A Software
System Based on the 7-Point Check-List, Proc. 43d Hawaii Int'l
Conf. on System Sciences, 2010; [0420] Foncubierta-Rodriguez et al,
Ground Truth Generation in Medical Imaging, Proc. of the ACM
Multimedia 2012 workshop on Crowdsourcing for Multimedia, pp. 9-14;
[0421] Fuketa, et al, Large-Area and Flexible Sensors with Organic
Transistors, 5th IEEE Int'l Workshop on Advances in Sensors and
Interfaces, 2013; [0422] Jacobs et al, Focal Stack Compositing for
Depth of Field Control, Stanford Computer Graphics Laboratory
Technical Report 2012-1; [0423] Johnson, et al, Retrographic
Sensing for the Measurement of Surface Texture and Shape, 2009 IEEE
Conf. on Computer Vision and Pattern Recognition; [0424] Kaliyadan,
Teledermatology Update--Mobile Teledermatology, World Journal of
Dermatology, May 2, 2013, pp. 11-15; [0425] Liu, et al,
Incorporating Clinical Metadata with Digital Image Features for
Automated Identification of Cutaneous Melanoma, pre-print from
British Journal of Dermatology, Jul. 31, 2013; [0426] Lyons, et al,
Automatic classification of single facial images, IEEE Trans. on
Pattern Analysis and Machine Intelligence, Vol. 21, No. 12, 1999,
pp. 1357-1362; [0427] Parsons, et al, Noninvasive Diagnostic
Techniques for the Detection of Skin Cancers, in Comparative
Effectiveness Technical Briefs, No. 11, US Agency for Healthcare
Research and Quality, September, 2011; [0428] Seal, et al,
Automated Thermal Face Recognition Based on Minutiae Extraction,
Int. J. Computational Intelligence Studies, 2013, No. 2, 133-156;
[0429] Vellido, et al, Neural Networks and Other Machine Learning
Methods in Cancer Research, in Computational and Ambient
Intelligence, Springer, 2007, pp. 964-971; [0430] Wadhawan, et al,
SkinScan: A Portable Library for Melanoma Detection on Handheld
Devices, Proc. IEEE Int'l Symp. on Biomedical Imaging, Mar. 30,
2011, pp. 133-136; [0431] Wolf et al, Diagnostic Inaccuracy of
Smartphone Applications for Melanoma Detection, JAMA Dermatology,
Vol. 149, No. 4, April 2013; and [0432] Zeng, et al, Colour and
Tolerance of Preferred Skin Colours, Color and Imaging Conference,
Society for Imaging Science and Technology, 2010.
[0433] The artisan is presumed to be familiar with such art.
[0434] This specification details a variety of arrangements. It
should be understood that the methods, elements and concepts
detailed in connection with one arrangement can be combined with
the methods, elements and concepts detailed in connection with
other embodiments. (For example, methods, principles and
arrangements described in connection with imagery can be applied in
connection with audio, etc., and vice versa. Similarly, polarized
light can be used advantageously in embodiments employing SLAM or
SFM techniques, and in detecting robust feature points. Etc.)
Likewise with features from the cited references. While some such
arrangements have been particularly described, many have not--due
to the large number of permutations and combinations. However,
implementation of all such combinations is straightforward to the
artisan from the provided teachings.
[0435] While this disclosure has detailed particular ordering of
acts and particular combinations of elements, it will be recognized
that other contemplated methods may re-order acts (possibly
omitting some and adding others), and other contemplated
combinations may omit some elements and add others, etc.
[0436] Although disclosed as complete systems, sub-combinations of
the detailed arrangements are also separately contemplated (e.g.,
omitting various features of a complete system).
[0437] While certain aspects of the technology have been described
by reference to illustrative methods, it will be recognized that
apparatuses configured to perform the acts of such methods are also
contemplated as part of applicant's inventive work. Likewise, other
aspects have been described by reference to illustrative apparatus,
and the methodology performed by such apparatus is likewise within
the scope of the present technology. Still further, tangible
computer readable media containing instructions for configuring a
processor or other programmable system to perform such methods is
also expressly contemplated.
[0438] The present specification should be read in the context of
the cited references. (The reader is presumed to be familiar with
such prior work.) Those references disclose technologies and
teachings that applicant intends be incorporated into embodiments
of the present technology, and into which the technologies and
teachings detailed herein be incorporated.
[0439] To provide a comprehensive disclosure, while complying with
the statutory requirement of conciseness, applicant
incorporates-by-reference each of the documents referenced herein.
(Such materials are incorporated in their entireties, even if cited
above in connection with specific of their teachings. For example,
while patent publication 20110301441 was referenced in connection
with purpose-built imaging hardware, other technologies disclosed
in that publication can also be used advantageously herein.)
[0440] In view of the wide variety of embodiments to which the
principles and features discussed above can be applied, it should
be apparent that the detailed embodiments are illustrative only,
and should not be taken as limiting the scope of the technology.
Rather, applicant claims all such modifications as may come within
the scope and spirit of the attached claims and equivalents
thereof.
* * * * *