U.S. patent application number 14/267403 was filed with the patent office on 2014-08-28 for composition with sustained antimicrobial activity.
The applicant listed for this patent is The Trustees of Columbia University in the City of New York. Invention is credited to Santoshkumar Dongre, Shanta M. Modak.
Application Number | 20140243417 14/267403 |
Document ID | / |
Family ID | 48193029 |
Filed Date | 2014-08-28 |
United States Patent
Application |
20140243417 |
Kind Code |
A1 |
Modak; Shanta M. ; et
al. |
August 28, 2014 |
Composition with Sustained Antimicrobial Activity
Abstract
Disclosed herein are compositions comprising benzyl alcohol, one
or more cationic antimicrobial agent, and one or more emollient,
the combination of which results in persistent antimicrobial
activity after application to the skin. The compositions optionally
further comprise an organic acid and/or a zinc salt, such as zinc
gluconate, as an anti-irritant.
Inventors: |
Modak; Shanta M.; (River
Edge, NJ) ; Dongre; Santoshkumar; (New York,
NY) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
The Trustees of Columbia University in the City of New
York |
New York |
NY |
US |
|
|
Family ID: |
48193029 |
Appl. No.: |
14/267403 |
Filed: |
May 1, 2014 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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PCT/US12/63013 |
Nov 1, 2012 |
|
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14267403 |
|
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61555367 |
Nov 3, 2011 |
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61583505 |
Jan 5, 2012 |
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61668160 |
Jul 5, 2012 |
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Current U.S.
Class: |
514/635 |
Current CPC
Class: |
A61K 31/14 20130101;
A61K 8/43 20130101; A61K 8/34 20130101; A01N 47/40 20130101; A61K
31/045 20130101; A61K 8/416 20130101; A61K 8/39 20130101; A61Q
17/005 20130101; A61K 31/045 20130101; A61K 2300/00 20130101; A61K
31/14 20130101; A61K 2300/00 20130101 |
Class at
Publication: |
514/635 |
International
Class: |
A01N 47/40 20060101
A01N047/40 |
Claims
1. A composition for topical application comprising: (i) benzyl
alcohol at a concentration of between about 0.1 and about 5% w/w;
(ii) one or more cationic antimicrobial agent selected from the
group consisting of a quaternary ammonium compound, a biguanide,
and a combination thereof, wherein the quaternary ammonium
compound, if present, is at a concentration of between about 0.05
and about 1% w/w and the biguanide, if present, is at a
concentration of between about 0.05 to about 3.0% w/w; and (iii)
one or more emollient selected from the group consisting of
dipropylene glycol, farnesol, and combinations thereof, at a
concentration effective in producing persistent antimicrobial
activity after application to the skin.
2. The composition of claim 1, further comprising an organic
acid.
3. The composition of claim 2, where the organic acid is selected
from the group consisting of lactic acid, citric acid, glycolic
acid, salicylic acid, mandelic acid and benzoic acid.
4. The composition of claim 1, further comprising a zinc salt as an
anti-irritant.
5. The composition of claim 1, further comprising an anti-irritant
selected from the group consisting of bisabolol, aloe vera gel,
aloe leaf extract, and combinations thereof.
6. The composition of claim 1, further comprising a component
selected from the group consisting of propylene glycol, glycerin,
polyglycerol, butylene glycol, pentylene glycol, hexanediol,
octanediol, ethyl hexyl glycerin, caprylic triglyceride, capric
triglyceride, panthenol, lauric alcohol, emu oil, grapeseed oil,
olive oil, and combinations thereof.
7. The composition of claim 1, further comprising a polyethylene
oxide polymer.
8. The composition of claim 1, further comprising oat flour, oat
extract or combinations thereof.
9. The composition of claim 1, which is a formulation selected from
the group consisting of soap, hand sanitizer, cream, lotion,
splash, astringent and wipe.
10. A method of providing a skin surface with a persistent
antimicrobial activity, comprising treating the skin surface with a
composition according to claim 1.
11. A composition for topical application comprising: (i) benzyl
alcohol at a concentration of between about 0.1 and about 5% w/w;
(ii) polyaminopropyl biguanide at a concentration of between about
0.05 and about 3.0% w/w; and (iv) oat beta glucan, oat flour, oat
extract or a combination thereof.
Description
PRIORITY CLAIM
[0001] The present application is a continuation of International
Application No. PCT/US12/063,013, filed Nov. 1, 2012, which claims
priority to U.S. Provisional Patent Application Ser. No.
61/555,367, filed Nov. 3, 2011, U.S. Provisional Patent Application
Ser. No. 61/583,505, filed Jan. 5, 2012, and U.S. Provisional
Patent Application Ser. No. 61/668,160, filed Jul. 5, 2012, to each
of which priority is claimed and all of which are incorporated
herein by reference in their entireties.
1. INTRODUCTION
[0002] Disclosed herein are compositions comprising benzyl alcohol,
a cationic antimicrobial agent, and an emollient, the combination
of which results in persistent antimicrobial activity when applied
to the skin.
2. BACKGROUND
[0003] Hand hygiene guidelines for healthcare personnel published
by the Centers for Disease Control and Prevention recommend that
alcohol-based hand gels and foams be used routinely, with
intermittent thorough hand washing with soaps throughout the day.
Studies have shown that the rate of compliance by the healthcare
workers with the hand washing guidelines is lower than 50% partly
because of the possibility/fear of skin irritation with the
frequent use of soaps and partly due to lack of time. This problem
could be addressed by the development of soaps and other skin-care
products that have sufficient residual antibacterial activity on
the skin to inactivate newly introduced bacteria.
3. SUMMARY
[0004] Disclosed herein are compositions comprising benzyl alcohol,
one or more cationic antimicrobial agent, and one or more
sesquiterpenoid and/or emollient solvent, the combination of which
results in persistent antimicrobial activity after application to
the skin. The compositions optionally further comprise an organic
acid and/or one or more zinc salt as an anti-irritant.
[0005] In certain non-limiting embodiments, the composition
comprises a synergistic combination of benzyl alcohol and one or
more cationic antimicrobial agent such as a biguanide and/or a
quaternary ammonium compound.
[0006] In certain non-limiting embodiments, the emollient is
farnesol or dipropylene glycol. Without being limited by any
theory, it is believed that such emollients enhance penetration of
antimicrobial agents into the superficial layer of the skin,
thereby prolonging their action.
[0007] The compositions disclosed herein may be used as soaps, hand
sanitizers, creams, lotions, and splashes and may optionally be
comprised in wipes.
[0008] Also provided is a method of providing a skin surface with a
persistent antimicrobial activity, comprising treating the skin
surface with a composition as described herein.
4. DETAILED DESCRIPTION
[0009] For clarity and not by way of limitation the detailed
description is divided into the following subsections:
[0010] (i) benzyl alcohol;
[0011] (ii) antimicrobial agents;
[0012] (iii) sesquiterpenoids;
[0013] (iv) emollient solvents;
[0014] (v) organic acids;
[0015] (vi) additional components; and
[0016] (vii) compositions/methods of use.
[0017] "About" as that term is used herein means+10% of the recited
value.
[0018] "Persistent antimicrobial activity" is antimicrobial
activity that is retained after the initial exposure to the
composition, although not necessarily at the same level. In
non-limiting embodiments, use of the composition results in topical
antimicrobial activity for at least one hour or at least two hours
or at least four hours following exposure to the composition. In
specific non-limiting embodiments, the antimicrobial activity
remaining after one hour is a log 10 reduction in colony forming
units of at least 0.5, or at least 1, or at least 1.5, for example
as determined by tests set forth below in section 5. In other
specific non-limiting embodiments, the antimicrobial activity
remaining after two hours is a log 10 reduction in colony forming
units of at least 0.5, or at least 1, or at least 1.5, for example
as determined by tests set forth below in section 5.
4.1 Benzyl Alcohol
[0019] The compositions disclosed herein comprise benzyl alcohol,
at a concentration (percent weight/weight, "% w/w") between about
0.1 and about 5% w/w, or between about 0.1 and about 3% w/w, or
between about 1.0 and about 3% w/w; or between 0.5 and 2% w/w. In
specific non-limiting embodiments the benzyl alcohol is
plant-derived.
[0020] In certain, non-limiting embodiments, the compositions
disclosed herein comprise benzyl alcohol, at a concentration
(percent weight/weight, "% w/w") between about 0.05 and about 5%
w/w; or between about 0.05 and about 4.5% w/w; or between about
0.05 and about 4% w/w; or between about 0.05 and about 3.5% w/w; or
between about 0.05 and about 3% w/w; or between about 0.05 and
about 2.5% w/w; or between about 0.05 and about 2% w/w; or between
about 0.05 and about 1.5% w/w; or between about 0.05 and about 1%
w/w; or between about 0.05 and about 0.5% w/w; or between about
0.05 and about 0.45% w/w; or between about 0.05 and about 0.4% w/w;
or between about 0.05 and about 0.35% w/w; or between about 0.05
and about 0.3% w/w; or between about 0.05 and about 0.25% w/w; or
between about 0.05 and about 0.2% w/w; or between about 0.05 and
about 0.15% w/w; or between about 0.05 and about 0.1% w/w; or
between about 0.1 and about 0.5% w/w; or between about 0.1 and
about 0.45% w/w; or between about 0.1 and about 0.4% w/w; or
between about 0.1 and about 0.35% w/w; or between about 0.1 and
about 0.3% w/w; or between about 0.1 and about 0.25% w/w; or
between about 0.1 and about 0.2% w/w; or between about 0.1 and
about 0.15% w/w.
4.2 Antimicrobial Agents
[0021] The compositions disclosed herein comprise one or more
cationic antimicrobial agent. In certain non-limiting embodiments,
the cationic antimicrobial agent(s) is (are) selected from the
group consisting of quaternary ammonium antimicrobial compounds,
antimicrobial biguanides, and combinations thereof. Quaternary
ammonium antimicrobial compound, where present, is at a
concentration between about 0.05 and 1% w/w, or between about 0.05
and about 0.5% w/w, or between about 0.1 and about 0.3% w/w, or
between 0.1 and 0.23% w/w (if more than one species of quaternary
ammonium antimicrobial compound is present, the foregoing are the
concentration ranges of the total amount of all species present).
Antimicrobial biguanide, where present, is at a concentration
between about 0.05 and about 3.0% w/w, or between about 0.05 and
1.5% w/w, or between about 0.05 and about 1.0% w/w, or between
about 0.05 and about 0.8% w/w, or between 0.05 and 0.5% w/w, or
about 0.4% w/w; if more than one species of biguanide is present,
the foregoing are the concentrations/ranges of the total amount of
all species present.
[0022] Non-limiting examples of quaternary ammonium antimicrobial
compounds that may be used include benzalkonium chloride (BZK),
benzethonium chloride (BZT), dequalinium chloride,
alkyldimethylbenzylammonium chloride, cetyl pyridinium chloride,
methylbenzethonium chloride, cetalkonium chloride, cetrimonium
chloride, cetyl trimethyl ammonium bromide (cetrimide) dofanium
chloride, tetraethylammonium bromide, domiphen bromide, and
combinations thereof.
[0023] Non-limiting examples of biguanides that may be used include
chlorhexidine, as a free base or salt, polyhexamethylene biguanide
("PHMB"), alexidine, polyaminopropyl biguanide (e.g., Cosmocil CQ),
and combinations thereof. Chlorhexidine salts that may be used
include but are not limited to the following: chlorhexidine
diphosphanilate, chlorhexidine digluconate, chlorhexidine
diacetate, chlorhexidine dihydrochloride, chlorhexidine dichloride,
chlorhexidine dihydroiodide, chlorhexidine diperchlorate,
chlorhexidine dinitrate, chlorhexidine sulfate, chlorhexidine
sulfite, chlorhexidine thiosulfate, chlorhexidine di-acid
phosphate, chlorhexidine difluorophosphate, chlorhexidine
diformate, chlorhexidine dipropionate, chlorhexidine
di-iodobutyrate, chlorhexidine di-n-valerate, chlorhexidine
dicaproate, chlorhexidine malonate, chlorhexidine succinate,
chlorhexidine malate, chlorhexidine tartrate, chlorhexidine
dimonoglycolate, chlorhexidine mono-diglycolate, chlorhexidine
dilactate, chlorhexidine di-.alpha.-hydroxyisobutyrate,
chlorhexidine diglucoheptonate, chlorhexidine di-isothionate,
chlorhexidine dibenzoate, chlorhexidine dicinnamate, chlorhexidine
dimandelate, chlorhexidine di-isophthalate, chlorhexidine
di-2-hydroxy-napthoate, chlorhexidine embonate, and combinations
thereof.
[0024] The compositions may further comprise one or more
antimicrobial agent that is not a cationic antimicrobial agent.
Non-limiting examples of such additional agents include triclosan,
parachlorometaxylenol ("PCMX"), chloroeresol, chlorxylenol, benzyl
alcohol, bronopol, chlorbutanol, ethanol, phenoxyethanol,
phenylethyl alcohol, 2,4-dichlorobenzyl alcohol, thiomersal,
clindamycin, erythromycin, benzoyl peroxide, mupirocin, bacitracin,
polymyxin B, neomycin, triclosan, parachlorometaxylene, foscarnet,
miconazole, fluconazole, itriconazole, ketoconazole, povidone
iodine, combinations thereof and pharmaceutically acceptable salts
thereof. For example, but not by way of limitation, phenoxyethanol,
where present, may be at a concentration between about 0.1 and
about 1% w/w, and triclosan, where present, may be at a
concentration between about 0.025 to about 2% w/w, or between 0.15
and 1% w/w.
[0025] Another non-limiting example of an antimicrobial which may
be used is iodopropynylbutyl carbamate (IPBC; German plus), for
example at a concentration between 0.05 and 2% w/w.
4.3 Sesquiterpenoids
[0026] Compositions disclosed herein may comprise one or more
sesquiterpenoid selected from the group consisting of farnesol,
nerolidol, bisabolol, apritone and combinations thereof. Where
present, the sesquiterpenoid (e.g. farnesol) is at a concentration
between about 0.1 and about 4% w/w, or between about 0.1 and about
3% w/w, or between about 0.3 and about 3% w/w, or between about 1
and 3% w/w, or between about 0.1 and 0.3% w/w; or between about 0.5
and about 4% w/w, or between about 0.5 and 3% w/w; or between about
0.5 and 0.3% w/w.
4.4 Emollient Solvents
[0027] Compositions disclosed herein may comprise one or more
emollient solvent selected from the group consisting of dipropylene
glycol, diglycerol, ethyl hexyl glycerin and combinations thereof.
Dipropylene glycol or diglycerol, where present, is at a
concentration of between about 0.1 and 10% w/w, or between about 1
and about 5% w/w, or between 0.2 and 7% w/w, or between 0.1 and 4%
w/w, or between 0.2 and 5% w/w; or ethyl hexyl glycerin where
present, is at a concentration between about 0.3 and about 4% w/w,
or between about 0.3 and 3% w/w, or between about 0.5 and about 3%
w/w, or between 1 and 3% w/w, or between 0.5 and 1.0% w/w.
[0028] Additional compounds with emollient properties that may
optionally be comprised in the compositions include, for example,
butylene glycol, pentylene glycol, a C.sub.3-C.sub.12 alkanediol, a
C.sub.5-C.sub.10 alkanediol, butanediol, pentanediol, hexanediol,
octanediol, Symdiol.TM., emu oil, grapeseed oil, olive oil,
caprylic/capric triglyceride, panthenol, lauric alcohol, propylene
glycol, glycerin, isopropyl myristate and combinations thereof. In
non-limiting examples, alkanediol may be present at a concentration
between about 0.5 and about 2.0% w/w, or between about 0.5 and
about 1.0% w/w, or between about 0.2 and about 2% w/w, or between
about 0.2 and about 1.0% w/w; octanediol may be at a concentration
between about 0.5 and about 2% w/w, or between about 0.5 and about
1.0% w/w; and butylene glycol may be present at a concentration
between about 0.5 and about 3% w/w.
4.5 Organic Acids
[0029] Organic acids that may be used in the disclosed compositions
include lactic acid, citric acid, salicylic acid, glycolic acid,
mandelic acid, benzoic acid and combinations thereof. In
non-limiting examples, an organic acid may be at a concentration
between about 0.1 and about 2% w/w.
4.6 Additional Components
[0030] The compositions may contain additional components known in
the art for use in soaps, skin sanitizers, and other topical
compositions.
[0031] In certain non-limiting embodiments, the composition may
comprise a polyethylene oxide (Polyox) hydrogel polymer which,
without being bound to any particular theory, can help the skin
retain moisture.
[0032] In certain non-limiting embodiments, the composition may
comprise an anti-irritant component, for example a zinc salt, such
as zinc gluconate, alpha bisabolol, aloe gel/leaf juice, oat beta
glucan, oat flour, oat extract and combinations thereof. Further
non-limiting examples of zinc salts that may be used include zinc
acetate, zinc butyrate, zinc citrate, zinc glycerate, zinc
glycolate, zinc formate, zinc lactate, zinc picolinate, zinc
propionate, zinc salicylate, zinc tartrate, zinc undecylenate, zinc
oxide, zinc stearate and combinations thereof. For example, a
combination of aloe gel/leaf juice and alpha bisabolol may be used
where the ratio of bisabolol to aloe gel/leaf juice may be between
about 1:1 to 1:10. In non-limiting embodiments, the concentration
of zinc salt may be between about 0.1 and about 2.0% w/w, the
concentration of bisabolol may be between about 0.01 and about 0.2%
w/w, and/or the concentration of Aloe gel/leaf juice may be between
about 0.125 and about 2.0%. In non-limiting embodiments, the oat
beta glucan, the oat flour or oat extract may be between about
0.5-5.0% w/w.
[0033] For example, a composition disclosed herein may further
comprise a thickening and/or gelling agent such as polyethylene
oxide (Polyox) hydrogel polymer, stearyl alcohol, cellulose
polymer, cationic hydroxy ethyl cellulose (e.g., Ucare; JR30),
hydroxy propyl methyl cellulose, hydroxy propyl cellulose (Klucel),
chitosan pyrrolidone carboxylate (Kytamer), behenyl alcohol, zinc
stearate, emulsifying waxes, including but not limited to Incroquat
and Polawax, an addition polymer of acrylic acid, a resin such as
Carbopol.RTM. ETD 2020, guar gum, acacia, acrylates/steareth-20
methacrylate copolymer, agar, algin, alginic acid, ammonium
acrylate co-polymers, ammonium alginate, ammonium chloride,
ammonium sulfate, amylopectin, attapulgite, bentonite, C.sub.9-15
alcohols, calcium acetate, calcium alginate, calcium carrageenan,
calcium chloride, caprylic alcohol, carbomer 910, carbomer 934,
carbomer 934P, carbomer 940, carbomer 941, carboxymethyl
hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar,
carrageenan, cellulose, cellulose gum, cetearyl alcohol, cetyl
alcohol, corn starch, damar, dextrin, dibenzlidine sorbitol,
ethylene dihydrogenated tallowamide, ethylene diolamide, ethylene
distearamide, gelatin, guar gum, guar hydroxypropyltrimonium
chloride, hectorite, hyaluronic acid, hydrated silica, hydroxybutyl
methylcellulose, hydroxyethylcellulose, hydroxyethyl
ethylcellulose, hydroxyethyl stearamide-MIPA, isocetyl alcohol,
isostearyl alcohol, karaya gum, kelp, lauryl alcohol, locust bean
gum, magnesium aluminium silicate, magnesium silicate, magnesium
trisilicate, methoxy PEG-22/dodecyl glycol copolymer,
methylcellulose, microcrystalline cellulose, montmorillonite,
myristyl alcohol, oat flour, oleyl alcohol, palm kernel alcohol,
pectin, PEG-2M, PEG-5M, polyacrylic acid, polyvinyl alcohol,
potassium alginate, potassium aluminium polyacrylate, potassium
carrageenan, potassium chloride, potassium sulfate, potato starch,
propylene glycol alginate, sodium acrylate/vinyl alcohol copolymer,
sodium carboxymethyl dextran, sodium carrageenan, sodium cellulose
sulfate, sodium chloride, sodium polymethacylate, sodium
silicoaluminate, sodium sulfate, stearalkonium bentotnite,
stearalkonium hectorite, stearyl alcohol, tallow alcohol,
TEA-hydrochloride, tragacanth gum, tridecyl alcohol, tromethamine
magnesium aluminium silicate, wheat flour, wheat starch, xanthan
gum, abietyl alcohol, acrylinoleic acid, aluminum behenate,
aluminum caprylate, aluminum dilinoleate, aluminum salts, such as
distearate, and aluminum isostearates, beeswax, behenamide,
butadiene/acrylonitrile copolymer, C29-70 acid, calcium behenate,
calcium stearate, candelilla wax, carnauba, ceresin, cholesterol,
cholesterol hydroxystearate, coconut alcohol, copal, diglyceryl
stearate malate, dihydroabietyl alcohol, dimethyl lauramine oleate,
dodecanoic acidlcetearyl alcohol/glycol copolymer, erucamide,
ethylcellulose, glyceryl triacetyl hydroxystearate, glyceryl
tri-acetyl ricinolate, glycol dibehenate, glycol di-octanoate,
glycol distearate, hexanediol distearate, hydrogenated C.sub.6-14
olefin polymers, hydrogenated castor oil, hydrogenated cottonseed
oil, hydrogenated lard, hydrogenated menhaden oil, hydrogenated
palm kernel glycerides, hydrogenated palm kernel oil, hydrogenated
palm oil, hydrogenated polyisobutene, hydrogenated soybean oil,
hydrogenated tallow amide, hydrogenated tallow glyceride,
hydrogenated vegetable glyceride, hydrogenated vegetable oil, Japan
wax, jojoba wax, lanolin alcohol, shea butter, lauramide, methyl
dehydroabietate, methyl hydrogenated rosinate, methyl rosinate,
methylstyrene/vinyltoluene copolymer, microcrystalline wax, montan
acid wax, montan wax, myristyleicosanol, myristyloctadecanol,
octadecene/maleic anhyrdine copolymer, octyldodecyl stearoyl
stearate, oleamide, oleostearine, ouricury wax, oxidized
polyethylene, ozokerite, paraffin, pentaerythrityl hydrogenated
rosinate, pentaerythrityl tetraoctanoate, pentaerythrityl rosinate,
pentaerythrityl tetraabietate, pentaerythrityl tetrabehenate,
pentaerythrityl tetraoleate, pentaerythrityl tetrastearate,
ophthalmic anhydride/glycerin/glycidyl decanoate copolymer,
ophthalmic/trimellitic/glycols copolymer, polybutene, polybutylene
terephthalate, polydipentene, polyethylene, polyisobutene,
polyisoprene, polyvinyl butyral, polyvinyl laurate, propylene
glycol dicaprylate, propylene glycol dicocoate, propylene glycol
diisononanoate, propylene glycol dilaurate, propylene glycol
dipelargonate, propylene glycol distearate, propylene glycol
diundecanoate, PVP/eiconsene copolymer, PVP/hexadecene copolymer,
rice bran wax, stearlkonium bentonite, stearalkonium hectorite,
stearamide, stearamide DEA-distearate, stearamide DIBA-stearate,
stearamide MEA-stearate, stearone, stearyl erucamide, stearyl
stearate, stearyl stearoyl stearate, synthetic beeswax, synthetic
wax, trihydroxystearin, triisononanoin, triisostearin,
tri-isostearyl trilinoleate, trilaurin, trilinoleic acid,
trilinolein, trimyristin, triolein, tripalmitin, tristearin, zinc
laurate, zinc myristate, zinc neodecanoate, zinc rosinate, and
mixtures thereof. Gelling agents used in vehicles may be natural
gelling agents such as natural gums, starches, pectins, agar and
gelatin, and may be based on polysaccharides or proteins Examples
include but are not limited to guar gum, xanthum gum, alginic acid
(E400), sodium alginate (E401), potassium alginate (E402), ammonium
alginate (E403), calcium alginate (E404,-polysaccharides from brown
algae), agar (E406, a polysaccharide obtained from red seaweeds),
carrageenan (E407, a polysaccharide obtained from red seaweeds),
locust bean gum (E410, a natural gum from the seeds of the Carob
tree), pectin (E440, a polysaccharide obtained from apple or
citrus-fruit), and gelatin (E441, made by partial hydrolysis of
animal collagen), pentylene glycol 4-t-nutylcyclohexanol (Symsitive
1609).
[0034] A composition as disclosed herein may optionally further
comprise a surfactant. The surfactant may be a cationic surfactant,
an ampholytic surfactant, or a nonionic surfactant. Non-limiting
examples of surfactants include polyethoxylates, fatty alcohols
(e.g., ceteth-20 (a cetyl ether of polyethylene oxide having an
average of about 20 ethylene oxide units) and other "BRIJ".TM.
nonionic surfactants available from ICI Americas, Inc. (Wilmington,
Del.)), cocamidopropyl betaine, alkyl phenols, fatty acid esters of
sorbitol, sorbitan, or polyoxyethylene sorbitan.
[0035] A composition as disclosed herein may optionally further
comprise an alcohol or a mixture of alcohols, for example, ethanol,
isopropyl alcohol, n-propyl alcohol, and mixtures thereof; fatty
alcohols, including, but not limited to, cetyl alcohol, myristol
alcohol, stearyl alcohol, octyl alcohol, decyl alcohol and lauryl
alcohol, and mixtures thereof; hexanol, and/or other aliphatic or
aromatic alcohol.
[0036] A composition as disclosed herein may optionally further
comprise a silicone polymer or silicone fluid, for example one or
more than one polydimethylsiloxane polymer (Dow Corning 225
Silicone Fluid), dimethiconol fluid in dimethicone (Dow Corning
1403 Silicone Fluid), Silsurf J208 (Siltech LLC, 30019)
cyclomethicone and dimethicone copolyl (Dow Corning 3225C Silicone
Fluid), Dow Corning 190 and 193 surfactants, polyarylsiloxanes,
polyalkylarylsiloxanes, polysiloxane gums, polyether siloxane
copolymers, dimethicone polysiloxane, dimethiconol, polysiloxanes,
polysiloxane copolymers, polyalkyl aryl silanes, polyaryl
siloxanes, polyalkyl siloxanes, polyalkyl aryl silanes,
polysiloxane copolymers, alkyl dimethicones, alkylmethicones,
alkyldimethicone copoloyls, phenyl silicones, alkyl
trimethylsilanes, dimethicone crosspolymer, trisiloxaDC silicone
fluid 1404, 1503, silicone glycol (BASF 1066 DCG polyol), GE
silicones, dimethicones, cyclomethicones, Bis PEG 15 Methyl ether
dimethicone, Dow Corning 2501cosmetic wax, and combinations
thereof.
[0037] A composition as disclosed herein may optionally further
comprise one or more essential oil and/or individual constituent
thereof, one or more additives such as dyes, fragrances, pH
adjusters, including basic pH adjusters such as ammonia, mono-, di-
and tri-alkyl amines, mono-, di- and tri-alkanolamines, alkali
metal and alkaline earth metal hydroxides (e.g., ammonia, sodium
hydroxide, potassium hydroxide, lithium hydroxide,
monoethanolamine, triethylamine, isopropylamine, diethanolamine and
triethanolamine); acid pH adjusters such as mineral acids and
polycarboxylic acids; vitamins such as vitamin A, vitamin E and
vitamin C; polyamino acids and salts, such as ethylenediamine
tetraacidic acid (EDTA), preservatives such as Germall plus and
DMDM hydantoin, and sunscreens such as aminobenzoic acid,
arobenzone, cinoxate, diioxybenzone, homosalate, menthyl
anthranilate, octocrylene, octyl methoxycinnarnate, octyl
salicylate, oxybenzoate, padimate O, phenylbenzimidazole, sulfonic
acid, sulisobenzone, titanium dioxide, trolamine salicylate and
zinc oxide.
[0038] In certain non-limiting embodiments the composition does not
contain a cationic emulsifier selected from the group consisting of
include incroquat compounds such as (but not limited to)
behenyltrimonium methosulfate in cetearyl alcohol (e.g., incroquat
behenyl TMS and incroquat behenyl TMS 50 (Croda Inc., Edison,
N.J.)), behenalkonium chloride and cetyl alcohol Incroquat B-65
(Croda Inc., Edison, N.J.)), behenamido propyl ethyl dimonium
ethosulfate and stearyl alcohol (Incroquat BES-35 S (Croda Inc.,
Edison, N.J.)), steralkonium chloride and cetearyl alcohol and
PEG-40 Castor oil (e.g., Incroquat CR concentrate (Croda Inc.,
Edison, N.J.)), Incroquat CTC-30 (Croda Inc., Edison, N.J.),
Incroquat DBM-90 (Croda Inc., Edison, N.J.), Incroquat 0-50 (Croda
Inc., Edison, N.J.), Incroquat S-DQ-25 (Croda Inc., Edison, N.J.),
Incroquat BA-85 (Croda Inc., Edison, N.J.), Incroquat WG-85 (Croda
Inc., Edison, N.J.), as well as distearyldimonium chloride (e.g.,
VARISOFT.RTM. TA 100 (Essen-Degussa, Germany)),
palmitamidopropyltrimonium chloride (e.g., VARISOFT.RTM. PATC
(Essen-Degussa, Germany)), and cetearyl alcohol (and)
palmitamiclopropyltrimonium chloride (e.g., TEGO.RTM. Care CE
40).
4.7 Compositions/Methods of Use
[0039] In non-limiting embodiments, the compositions are embodied
as soap, cleansing foam, leave-on hand sanitizer,
alcohol-containing hand sanitizer or soap, alcohol-free hand
sanitizer or soap, lotion, cream, splash, astringent, or wipe
formulations. The formulations may be applied to humans or
non-human animals (for example, for veterinary or agricultural
purposes). Non-limiting examples are described below by way of
illustration but further embodiments would be envisaged by the
person of skill in the art.
[0040] In one set of non-limiting embodiments, the composition is a
soap comprising the following components:
TABLE-US-00001 Ingredients (% w/w) Benzyl alcohol 1.0-3.0
Benzethonium chloride and/or Benzalkonium chloride 0.1-0.23
Biguanide 0.05-0.6 Dipropylene Glycol and/or diglycerin 1.0-5.0
Farnesol 0.3-3.0 Organic acid 0.0-2.0
This composition may further contain one or more of the following
anti-irritants:
TABLE-US-00002 Zinc gluconate/Zinc lactate 0.1-0.2 Bisabolol
0.01-0.2 Aloe leaf juice 0.125-1.0
This composition may have a pH between about 5 and about 6.8.
[0041] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00003 Ingredients (% w/w) Benzyl alcohol 1.0-3.0
Benzethonium chloride/Benzalkonium chloride 0.1-0.23 Chlorhexidine
and/or PHMB 0.05-0.6 Dipropylene Glycol/diglycerin 1.0-5.0 Farnesol
0.3-3.0 Organic acid 0.0-2.0 Pluronic F-87 prill 0.5-2.0
Hydroxypropyl methylcellulose (Methocel) 0.1-0.5 Non ionic poly
(ethylene Oxide) Polymer (Polyox) 0.1-1.0 Incromine Oxide L 3.0-5.0
Montalene C 40 3.0-8.0 Germall Plus 0.0-2.0 Water 55-70 Glycerin
1.0-3.0 SDA-40 B alcohol 5.0-15 Butylene glycol 1.0-3.0 Dehydroquat
(Cetrimonium chloride) .sup. 0-2.0 Phenoxyethanol/Phenylethanol
0.0-1.0 Alkanediol 0.2-2.0 Zinc gluconate/Zinc lactate .sup. 0-0.2
Bisabolol .sup. 0-0.2 Aloe leaf juice .sup. 0-1.0
This composition may have a pH between about 5 and about 6.8.
[0042] In one specific non-limiting embodiment, the composition is
a soap ("LPS-14E") having the following formulation:
TABLE-US-00004 Ingredients % w/w Benzyl alcohol 2.0 Benzethonium
chloride 0.23 Dipropylene Glycol 5.0 Farnesol 1.0 Lactic acid 0.2
Zinc gluconate 0.2 Pluronic F-87 prill 1.0 Methocel E4 M 0.2
PolyoxWSR 205 0.3 Incromine Oxide L 5.0 Montalene C 40 8.0 Germall
Plus 0.2 Water 64.27 Glycerine 1.0 SDA-40 B alcohol 8.0 Butylene
glycol 1.0 Phenoxyethanol 1.0 PHMB 0.4 Octanediol 1.0 pH
5.2-5.5
[0043] In one specific non-limiting embodiment, the composition is
a soap ("LPS-14F") having the following formulation:
TABLE-US-00005 Ingredients % w/w Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Farnesol 2.0 Zinc
gluconate 0.2 Pluronic F-87 prill 1.0 Methocel E4 M 0.2 PolyoxWSR
205 0.5 Incromine Oxide L 3.0 Montalene C 40 8.0 Water 57.12
Glycerine 1.0 SDA-40 B alcohol 15.0 Butylene glycol 1.0
Phenoxyethanol 1.0 Octanediol 1.0 Dehydroquat 1.0 Bisabolol 0.025
Aloe leaf juice 0.25 pH 5.2-5.5
[0044] In one specific non-limiting embodiment, the composition is
a soap ("ILS-14F7-2") having the following formulation:
TABLE-US-00006 Ingredients % w/w Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Farnesol 2.0 Zinc
gluconate 0.2 Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87
prill 1.0 Methocel E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L
3.42 Montalene C 40 8.0 Water 57.3 Glycerin 1.0 SDA-40 B alcohol
14.0 Butylene glycol 1.0 Phenoxyethanol 1.0 Octanediol 1.0 pH
5.6-6.0
[0045] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00007 Ingredients (% w/w) Pluronic F-87 prill 0.5-1.0
Methocel E4 M 0.1-0.5 PolyoxWSR 205 0.1-0.5 Incromine Oxide L
3.0-5.0 Montalene C 40 3.0-8.0 Germall Plus 0.0-2.0 Water 55-70
Zinc gluconate 0.0-0.2 Glycerin 1.0-3.0 SDA-40 B alcohol 5.0-15
Butylene glycol 1.0-3.0 Benzyl alcohol 1.0-3.0 Fruit acid 0.1-2.0
Benzethonium chloride and/or Benzalkonium chloride 0.1-0.23
Dipropylene Glycol and/or diglycerin 1.0-5.0 Farnesol 0.3-2.0
Phenoxyethanol and/or Phenylthanol 0.0-1.0 Chlorhexidine and/or
PHMB 0.05-0.6 Alkanediol 0.2-2.0
[0046] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00008 Ingredients (% w/w) Pluronic F-87 prill 0.5-1.0
Methocel E4 M 0.1-0.5 PolyoxWSR 205 0.1-0.5 Incromine Oxide L
3.0-5.0 Montalene C 40 3.0-8.0 Water 50-70 Zinc gluconate 0.1-0.2
Glycerine 1.0-3.0 SDA-40 B alcohol 5.0-15 Butylene glycol 1.0-3.0
Benzyl alcohol 1.0-3.0 Benzethonium chloride 0.1-0.23 Dipropylene
Glycol 1.0-5.0 Farnesol 0.3-3.0 Phenoxyethanol 0.0-1.0 PHMB
0.05-0.6 Octanediol 0.2-2.0 Bisabolol 0.01-1.0 Aloe leaf juice
0.1-2.0
[0047] In one specific non-limiting embodiment, the composition is
a soap ("LPS 3") having the following formulation:
TABLE-US-00009 Ingredients (% w/w) Pluronic F-87 prill 1.00
Methocel E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L 3.42
Montalene C 40 8.0 Water 57.3 Zinc gluconate 0.2 Glycerine 1.0
SDA-40 B alcohol 14.0 Butylene glycol 1.0 Benzyl alcohol 2.0
Benzethonium chloride 0.23 Dipropylene Glycol 5.0 Farnesol 2.0
Phenoxyethanol 1.0 PHMB 0.4 Octanediol 1.0 Bisabolol 0.1 Aloe leaf
juice 0.25
[0048] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00010 Ingredients (% w/w) Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Farnesol 2.0 Zinc
gluconate 0.2 Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87
prill 1.0 Methocel E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L
3.42 Montalene C 40 8.0 Water 57.3 Glycerine 1.0 SDA-40 B alcohol
14.0 Butylene glycol 1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0049] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00011 Ingredients (% w/w) Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Zinc gluconate 0.2
Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87 prill 1.0 Methocel
E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L 3.42 Montalene C 40
8.0 Water 59.3 Glycerine 1.0 SDA-40 B alcohol 14.0 Butylene glycol
1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0050] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00012 Ingredients (% w/w) Benzethonium chloride 0.23 PHMB
0.4 Dipropylene Glycol 5.0 Farnesol 2.0 Zinc gluconate 0.2
Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87 prill 1.0 Methocel
E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L 3.42 Montalene C 40
8.0 Water 59.3 Glycerine 1.0 SDA-40 B alcohol 14.0 Butylene glycol
1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0051] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00013 Ingredients (% w/w) Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Nerolidol 2.0 Zinc
gluconate 0.2 Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87
prill 1.0 Methocel E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L
3.42 Montalene C 40 8.0 Water 57.3 Glycerine 1.0 SDA-40 B alcohol
14.0 Butylene glycol 1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0052] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00014 Ingredients (% w/w) Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Bisabolol 2.0 Zinc
gluconate 0.2 Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87
prill 1.0 Methocel E4 M 0.2 PolyoxWSR 205 0.3 Incromine Oxide L
3.42 Montalene C 40 8.0 Water 57.3 Glycerine 1.0 SDA-40 B alcohol
14.0 Butylene glycol 1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0053] In one specific non-limiting embodiment, the composition is
a soap having the following formulation:
TABLE-US-00015 Ingredients (% w/w) Benzyl alcohol 2.0 Benzethonium
chloride 0.23 PHMB 0.4 Dipropylene Glycol 5.0 Apritone 2.0 Zinc
gluconate 0.2 Bisabolol 0.1 Aloe leaf juice 0.25 Pluronic F-87
prill 1.0 Methocel E4 M 0.2 Incromine Oxide L 3.42 Montalene C 40
8.0 Water 57.3 Glycerine 1.0 SDA-40 B alcohol 14.0 Butylene glycol
1.0 Phenoxyethanol 1.0 Octanediol 1.0
[0054] In one set of non-limiting embodiments, the composition is
an alcohol-free hand disinfectant foam comprising the following
components:
TABLE-US-00016 Ingredients % w/w Benzyl alcohol 0.5-2.0 Quaternary
ammonium compound 0.1-0.23 PHMB 0.05-0.6 Dipropylene Glycol 0.2-5.0
Farnesol 0.1-0.5 Fruit acid 0.-2.0
[0055] The composition may optionally further comprise one or more
of the following anti-irritants:
TABLE-US-00017 Zinc gluconate 0.1-0.5 Bisabolol + gingerextract
(Symrelief) 0.05-0.2 Aloe Barbedensis juice/gel 0.25-1.0
Siliconefluid/Polymer 0.25-2.0
[0056] In one specific non-limiting embodiment, the composition is
an alcohol-free hand disinfectant foam (HSBZT) having the following
formulation:
TABLE-US-00018 Ingredients % w/w Benzyl alcohol 0.5-2.0
Benzethonium chloride 0.1-0.23 PHMB 0.05-0.6 Dipropylene Glycol
0.2-5.0 Farnesol 0.1-0.5 Fruit acid 0.1-2.0 Zinc gluconate 0.1-0.5
Bisabolol + gingerextract (Symrelief) 0.05-0.2 Aloe Barbedensis
juice/gel 0.25-1.0 Water 60-80 Polyox WSR 205 0.05-0.2 Pluronic
F-87 0.5-1.0 Solubilizer 611674 0.5-2.0
[0057] (PEG-40 Hydrogenated castor oil, Trideceth-9,water)
TABLE-US-00019 Phenoxy ethanol 0.0-1.0 Octanediol 0.5-2.0.
Pentanediol 0.5-2.0 Arlasilk Phospholipid PTM 0.0-0.5 Montalene
C-40 0.25-1.0 Silsurf J208 0.25-2.0 pH to 4.00-4.5
[0058] In one set of non-limiting embodiments, the composition is
an alcohol-free hand disinfectant foam comprising the following
components:
TABLE-US-00020 Ingredients % w/w Benzyl alcohol 0.5-2.0
Benzalkonium chloride 0.1-0.23 PHMB 0.05-0.6 Dipropylene Glycol
0.2-5.0 Farnesol 0.1-0.5 Lactic acid 0.1-2.0
[0059] The composition may optionally further comprise one or more
of the following anti-irritants:
TABLE-US-00021 Zinc gluconate/Zinc lactate 0.1-0.2 Bisabolol +
gingerextract (Symrelief) 0.05-0.2 Aloe Barbedensis juice/gel
0.25-1.0
[0060] In one set of non-limiting embodiments, the composition is
an alcohol-free hand disinfectant foam comprising the following
components:
TABLE-US-00022 Ingredients (% w/w) Water 60-85 Zinc gluconate
0.1-0.2 Pluronic F-87 0.5-1.0 Bisabolol + gingerextract (Symrelief)
0.05-0.2 Aloe Barbedensis juice/gel 0.25-1.0 Benzethonium chloride
0.1-0.23 PHMB 0.05-0.6 Phenoxy ethanol 0.0-1.0 Pentanediol 0.5-2.0
Montalene C-40 0.5-3.0 Benzyl alcohol 0.5-2.0 Farnesol 0.5-2.0
Organic acid 0.2-0.5 Dipropylene Glycol 0.2-2.0 Propylene glycol
0.2-1.0 Glycerin 0.5-2.0 Ultrapure MFB1-1 0.2-2.0 pH to
4.00-4.2
[0061] In one specific non-limiting embodiment, the composition is
an alcohol-free hand disinfectant foam ("AQ-D14") comprising the
following components:
TABLE-US-00023 Ingredients (% w/w) Water 85.0 Zinc gluconate 0.2
Pluronic F-87 1.0 Bisabolol + gingerextract (Symrelief) 0.05 Aloe
Barbedensis juice/gel 0.5 Benzethonium chloride 0.18 PHMB 1.0
Phenoxy ethanol 0.5 Pentanediol 1.0 Montalene C-40 2.0 Benzyl
alcohol 1.0 Farnesol 0.3 Organic acid 0.2 Dipropylene Glycol 0.5
Propylene glycol 0.5 Glycerin 1.0 Ultrapure MFB1-1 1.0 pH to
4.00-4.2
[0062] In one specific non-limiting embodiment, the composition is
an alcohol hand disinfectant foam comprising the following
components:
TABLE-US-00024 Ingredient (% w/w) Water 25-35 SoftcatPolymerSL-100
0.05-0.2 Zinc gluconate 0.1-0.2 Glycerin 1.0-5.0 Benzethonium
chloride 0.12-2.3 Lactic acid 0.1-0.2 Glucam P-20 0.2-2.0 SDA 40B
alcohol 55-65 Benzyl alcohol 0.5-2.0 Lemongrass oil 0.01-0.03
Dowcorning silicone fluid 190 1.0-4.0 Aloe leaf juice 0.3-1.0
Symrelief 0.03-0.1 Ultrapure MFB -10 1.0-5.0 PHMB 0.1-0.3 pH
4.5-4.6
[0063] In one specific non-limiting embodiment, the composition is
an alcohol hand disinfectant foam comprising the following
components:
TABLE-US-00025 Ingredient (% w/w) Water 28.05 SoftcatPolymerSL-100
0.05 Zinc gluconate 0.2 Glycerin 1.0 Benzathonium chloride 0.18
Lactic acid 0.1 Glucam P-20 1.0 SDA 40B alcohol 60.0 Benzyl alcohol
1.0 Lemongrass oil 0.02 Dowcorning silicone fluid 190 1.0 Aloe leaf
juice 0.5 Symrelief 0.05 Ultrapure MFB -10 1.0 PHMB 0.3 pH
4.5-4.6
[0064] In one specific non-limiting embodiment, the composition is
an alcohol-free hand disinfectant lotion (HSBAC) having the
following formulation:
TABLE-US-00026 Ingredients % w/w Benzyl alcohol 0.5-2.0
Benzalkonium chloride 0.1-0.23 PHMB 0.05-0.6 Dipropylene Glycol
0.2-5.0 Farnesol 0.1-0.5 Lactic acid 0.1-2.0 Zinc gluconate/Zinc
lactate 0.1-0.2 Bisabolol + gingerextract (Symrelief) 0.05-0.2 Aloe
Barbedensis juice/gel 0.25-1.0 Polyox WSR 205 0.05-0.2 Polowax NF
0.5-2.0 Incroquat TMS 0.5-4.0 Stearyl alcohol 0.5-3.0 Isopropyl
myristate 0.5-2.0 Arlacel 165 0.5-1.0 Vit. E acetate 0.2-0.5 Zinc
oxide .sup. 0-1.0 Zn stearate 0.25-1.0 Glycerine 1.0-3.0 Water
.sup. 60-80.0 Polyquaternium 10 0.1-0.30 Butylene glycol 0.5-3.0
Allantoin 0.2-0.5 Alkanediol 0.2-1.0 Silicone fluid 03-1.0 pH to
5.5-6.0
[0065] In one specific non-limiting embodiment, the composition is
an alcohol-free hand disinfectant lotion having the following
formulation:
TABLE-US-00027 Ingredients (% w/w) Polowax NF 0.5-2.0 Incroquat TMS
0.5-4.0 Stearyl alcohol 0.5-3.0 Isopropyl myristate 0.5-2.0 Arlacel
165 0.5-1.0 Vit. E acetate 0.02-0.5 Zn oxide 0.0-2.0 Zn stearate
0.25-0.50 Glycerin 1.0-3.0 Dipropyleneglycol 0.5-2.0 Water .sup.
60-85.0 Polyquaternium 10 0.1-0.30 Polyox WSR 205 0.05-0.2 Butylene
glycol 0.5-3.0 Dipropylene glycol 0.2-5.0 Farnesol 0.5-2.0 Zinc
gluconate 0.0-0.2 Lactic acid 0.1-2.0 Benzalkonium Chloride
0.1-0.23 PHMB 0.05-0.6 Benzyl alcohol 0.5-2.0 Silicone fluid
0.3-1.0 Aloe leaf Juice 0.01-2.0 Symrelief 0.01-1.0 Adjust pH to
5.5-6.0
[0066] In one specific non-limiting embodiment, the composition is
an alcohol-free hand disinfectant lotion ("Lotion D-10") having the
following formulation:
TABLE-US-00028 Ingredients (%w/w) Polowax NF 2.0 Incroquat TMS 4.0
Stearyl alcohol 1.0 Isopropyl myristate 1.0 Arlacel 165 1.0 Vit. E
acetate 0.1 Zn oxide 0.25 Zn stearate 0.5 Glycerin 2.0
Dipropyleneglycol 1.0 Water 80.75 Polyquaternium 10 0.15 Polyox WSR
205 0.1 Butylene glycol 1.0 Farnesol 0.3 Zinc gluconate 0.2 Lactic
acid 0.2 Benzalkonium Chloride 0.12 PHMB 0.3 Benzyl alcohol 1.0
Silicone fluid 1.0 Aloe leaf Juice 0.5 Symrelief 0.05 Adjust pH to
5.5-6.0
[0067] In one specific non-limiting embodiment, the composition is
a wound-healing cream having the following formulation;
TABLE-US-00029 Ingredients % w/w Range (% w/w) White Petrolatum*
5.0 4-6 Stearyl Alcohol 13 10-15 Isopropyl Myristate 4.0 3-5
Sorbitan Oleate 1.6 1-2 Polyoxyl 40 Stearate(Myrj 52) 4.0 3-5
Dipropyleneglycol 1.0 0.5-3.0 Incroquat Behenyl TMS 1.0 0.5-3.0
Zinc Oxide 0.3 0.2-1.0 Polawax N.F 1.0 0.5-2.0 Zinc stearate 0.3
0.2-1.0 Water 63.85 55-70 Germall+ 0.2 0.1-0.3 Ascorbic
acid(Vitamin C) 1.0 0.5-2.0 Calendula Oil 0.5 0.3-1.-0 Benzyl
alcohol 0.1 0.1-0.5 PHMB 0.15 0.1-0.3 Benzoic acid 0.2 0.2-0.5
Sodium Benzoate 0.2 0.2-0.5 Resveretrol/Echinacea purpuria extract
0.5 0.3-1.0 Zinc lactate/Zinc gluconate 0.2 0.1-0.5 Aloe leaf
Barbadensis juice/Aloe gel 0.5 0.25-1.0 Alpha Bisabolol 0.1
0.05-0.2 Adjust pH to 5.8-6.0
[0068] In one specific non-limiting embodiment, the composition is
a wound-healing cream having the following formulation:
TABLE-US-00030 Ingredients % w/w Range (% w/w) White Petrolatum*
5.0 4-6 Stearyl Alcohol 13 10-15 Isopropyl Myristate 4.0 3-5
Sorbitan Oleate 1.6 1-2 Polyoxyl 40 Stearate(Myrj 52) 4.0 3-5
Dipropyleneglycol 1.0 0.5-3.0 Incroquat Behenyl TMS 1.0 0.5-3.0
Zinc Oxide 0.3 0.2-1.0 Polawax N.F 1.0 0.5-2.0 Zinc stearate 0.3
0.2-1.0 Water 63.85 55-70 Germall+ 0.2 0.1-0.3 Ascorbic
acid(Vitamin C) 1.0 0.5-2.0 Calendula Oil 0.5 0.3-1.-0 Benzyl
alcohol 0.1 0.1-0.5 PHMB 0.15 0.1-0.3 Benzoic acid 0.2 0.2-0.5
Sodium Benzoate 0.2 0.2-0.5 Rosemary oil 0.1 0.1-0.3
Resveratrol/Echinacea purpuria extract 0.5 0.3-1.0 Pomogranate oil
0.5 0.3-1.0 Zinc lactate/Zinc gluconate 0.2 0.1-0.5 Aloe leaf
Barbadensis juice/Aloe gel 0.5 0.25-1.0 Alpha Bisabolol 0.1
0.05-0.2 Adjust pH to 5.8-6.0
[0069] In one specific non-limiting embodiment, the composition is
a wound-healing cream having the following formulation:
TABLE-US-00031 Range Ingredients % w/w (% w/w) White Petrolatum*
5.0 4-6 Polyox WSR 205 0.1 0.05-0.3 Stearyl Alcohol 13 10-15
Isopropyl Myristate 4.0 3-5 Sorbitan Oleate 1.6 1-2 Polyoxyl 40
Stearate (Myrj 52) 4.0 3-5 Dipropyleneglycol 2.0 0.5-3.0 Incroquat
Behenyl TMS 1.0 0.5-3.0 Zinc Oxide 0.3 0.2-1.0 Polawax N.F 1.0
0.5-2.0 Zinc stearate 0.3 0.2-1.0 Water 63.85 55-70 Germall + 0.2
0.1-0.3 Ascorbic acid (Vitamin C) 1.0 0.5-2.0 Glucan (Symglucan
from Symrise) 5.0 2-10 Calendula Oil 0.5 0.3-1.-0 PHMB 0.15 0.1-0.3
Benzyl alcohol 0.1 0.1-0.5 Benzoic acid 0.2 0.2-0.5 Sodium Benzoate
0.2 0.2-0.5 Resveratrol/Echinacea purpuria extract 0.2 0.3-1.0 Zinc
lactate/Zinc gluconate 0.2 0.1-0.5 Aloe leaf Barbadensis juice/Aloe
gel 0.5 0.25-1.0 Alpha Bisabolol 0.1 0.05-0.2 Adjust pH to
5.8-6.0
[0070] In one specific non-limiting embodiment, the composition is
a first aid cream having the following formulation:
TABLE-US-00032 Ingredients (% w/w) Silver carbonate 0.1-0.3
Calendula Oil 0.3-1.-0 Curcumin 0.1-2.0 Benzyl alcohol 0.1-0.5
Farnesol 0.3-0.5 PHMB 0.1-0.3 Benzoic acid 0.2-0.5 Zinc gluconate
0.1-0.5 Alpha Bisabolol 0.05-0.2 Aloe leaf juice 0.3-1.0 White
Petrolatum 1.0-10.0 Stearyl Alcohol 5.0-20.0 Isopropyl Myristate
1.0-6.0 Sorbitan Oleate 0.5-5.0 Polyoxyl 40 Stearate (Myrj 52)
1.0-10.0 Germal + 0.05-2.0 Zinc Oxide 0.2-1.0 Zinc stearate 0.2-1.0
Water 55-70 Adjust pH to 5.8-6.0
[0071] In one specific non-limiting embodiment, the composition is
a first aid cream having the following formulation:
TABLE-US-00033 Ingredients (% w/w) Silver carbonate 0.2 Calendula
Oil 0.5 Curcumin 0.5 Benzyl alcohol 0.1 Farnesol 0.1 PHMB 0.15
Benzoic acid 0.2 Zinc gluconate 0.2 Alpha Bisabolol 0.1 Aloe leaf
juice 0.5 White Petrolatum 5.0 Stearyl Alcohol 13 Isopropyl
Myristate 4.0 Sorbitan Oleate 1.6 Polyoxyl 40 Stearate (Myrj 52)
4.0 Germal + 0.2 Zinc Oxide 0.3 Zinc stearate 0.3 Water 59.95
Adjust pH to 5.8-6.0
[0072] In one specific non-limiting embodiment, the composition is
a wound-healing cream having the following formulation:
TABLE-US-00034 Ingredient Range (% w/w) Stearyl Alcohol 5.0-20.0
Isopropyl Myristate 1.0-6.0 Sorbitan Oleate 0.2-3.0 Polyoxyl 40
Stearate(Myrj 52) 1.0-6.0 Dipropyleneglycol 0.1-4.0 Incroquat
Behenyl TMS 0.1-5.0 Zinc Oxide 0.01-2.0 Polawax N.F 0.1-3.0 Zinc
stearate 0.05-2.0 Water 40.0-90.0 Polyox WSR 205 0.01-1.0 Benzyl
alcohol 0.0-2.0 Germall + 0.05-2.0 Zinc lactate 0.01-1.0 Zinc
gluconate 0.01-0.1 Ascorbic acid(Vit. C) 0.01-2.0 Calendula oil
0.01-1.0 Cosmocil 0.05-3.0 Tetrahydrocurcuminoid 0.05-2.0 Rosemary
oil 0.05-2.0 Oat beta glucan (Sym glucan) 0.05-2.0 Oat flour/Oat
extract 0.5-5.0 Resveratrol/Echinacea extract 0.0-2.0 Pomogranate
oil 0.02-2.0 Aloe leaf Barbadensis juice/Aloe gel 0.5-5.0 Alpha
Bisabolol 0.01-2.0
5. EXAMPLE 1
Comparison of Persistent Activities of Commercial Soaps With LPS
14E- and LPS 14 7-2 (the Compositions of Which are Described
Above)
[0073] Method of Testing Substantive Activity:
[0074] Pigskins (3 cm.sup.2 mounted on petri dishes) were washed
with non antibacterial soap and rinsed under running tap water. 3
pairs for control (Soap base) and 3 pairs for test were used. 0.15
ml soap was added to each piece of the pair and rubbed for 30
seconds and rinsed each piece with 75 ml water. After 1 or 2 hours,
the pieces were contaminated with 10 .mu.l of 10.sup.5 Cfu/ml
bacterial culture. After 15 minutes the pieces were rinsed with 10
ml of drug inactivating fluid (DNF). The fluid was diluted and
plated on TSA. After incubation at 37.degree. C., the bacterial
counts were enumerated and the 3 soaps were compared [0075] 1="DC"
(0.46% T) Commercial soap containing 0.46% triclosan [0076]
2="TPB", Comercial soap containing 0.15% triclosan, PHMB and
Benzathonium chloride without emollients [0077] 3=LPS 14E Soap with
emollients [0078] 4=LPS 14F7-2 Soap with emollients
[0079] Log reduction is calculated from Control Growth which is
1.times.10.sup.3 to 5.times.10.sup.3 cfu (3-3.5 log 10)
[0080] The bacteria tested were, S. aureus (ATCC 6538) and E. coli
(ATCC 11229). The results of these experiments are shown in Table
1.
TABLE-US-00035 TABLE 1 Log10 reduction in colony-forming units,
mean .+-. SD S. aureus E. coli DC (0.46% T) 1 hour post wash 0.58
0.5 2 hour post wash 0.17 0.4 TPB (0.15% T) 1 hour post wash 0.9
0.7 2 hour post wash 0.7 0.7 LPS 14E 1 hour post wash 1.8 1.6 2
hour post wash 1.74 1.6 LPS 14F7-2 1 hour post wash 2.3 1.8 2 hour
post wash 1.9 1.9
[0081] Conclusion:
[0082] Activity against both S. aureus (gram positive) and E. coli
(gram negative) is seen even 2 hour after rinsing the skin with the
LPS14E and soap containing emollients LPS 14 F7-2 soap without
lactic acid provides slightly more substantive activity. Both DC
and TPB showed lower antimicrobial activity, and the antimicrobial
activity of the DC soap deteriorated over the testing interval.
6. EXAMPLE 2
Comparison of Persistent Activities of Commercial Hand Sanitizers
With HSBZT and HSBAC (The Compositions of which are Described
Above)
[0083] A method analogous to that used to test the soaps (above)
was used to test persistent antimicrobial activities of hand
sanitizers. The test organism was S. aureus and HSP is a commercial
alcohol-based hand sanitizer. The results are shown in Table 2.
TABLE-US-00036 TABLE 2 Log10 reduction from control counts
Disinfectant 1 hour post application 4 hour Post application HSBZT
2.851 2.130 HSBAC 3.2 2.9 HSP 0.102 0.050
Conclusion Both aqueous HSBZT and HSBAC show grater activity than
the commercial alcohol-based hand sanitizer tested.
7. EXAMPLE 3
Evaluation of Anti Irritant Composition (ZAB) in an Alcohol Based
Hand Disinfectant
[0084] Alcohol based hand disinfectant (ABHD)
TABLE-US-00037 Ingredients % w/w Alcohol SDA 40 B 70.0 Benzyl
alcohol 1.0 Lactic acid 0.2 Octanediol 1.0 Dipropylene glycol 1.0
Farnesol 0.5 Benzathonium chloride 0.18 PHMB 0.3 Polyquaternium-10
0.1 Hydroxypropyl methyl cellulose 0.1 Incromine oxide 1.0 Water
23.62 Total 99.0
[0085] ABHD with the following ingredients were prepared for
testing in volunteers for anti irritant effect. These ingredients
were added to the above ABHD and total weight adjusted to 100 gm
with water
TABLE-US-00038 ABHD Z ABHD containing 0.2% zincgluconate ABHDZ1
ABHD containing 0.2% zincgluconate + 0.2% Zinc lactate ABHD ZA ABHD
containing 0.2% zinc gluconate + 0.5% Aloe leaf juice ABHD ZB ABHD
containing 0.2% zinc gluconate + 0.2% bisabolol ABHD ZAB ABHD
containing 0.2% zinc gluconate + 0.5% Aloe leaf Juice + 0.2%
bisabolol ABHD ZAB 1 ABHD containing 0.2% zincgluconate + 0.25%
Aloe leaf Juice + 0.1% bisabolol
[0086] Volunteer Test Results:
[0087] Volunteer A had severe irritation when ABHD was applied on
the hand.
[0088] Volunteer B had moderate reaction
[0089] These two volunteers were used for the test.
[0090] Test Method:
[0091] 2 ml of the product is applied on the hand and dried the
reaction was observed after 10 minutes The hands were washed and
dried After 1 hour the second product was applied. Thus each
product was applied after 1 hour interval between application.
[0092] Grading of Irritation
[0093] 0=No reaction
[0094] 1=Mild itching
[0095] 2=Moderate itching
[0096] 3=Severe itching/slight redness
[0097] The results are shown in Table 3.
TABLE-US-00039 TABLE 3 Reaction Group Volunteer A Volunteer B ABHD
3.0 2.0 ABHD Z 3.0 2.0 ABHDZ1 2.5 1.5 ABHD ZA 1.5 0 ABHD ZB 2.0 0.5
ABHD ZAB 0 0 ABHD ZAB 1 1.0 0
[0098] Conclusion: ZAB provides good anti irritant protection. The
alcohol based hand disinfectant (ABHD produced ABHD) without anti
irritant Zinc salts produced severe itching and some redness
(grading #3).
8. EXAMPLE 4
Evaluation of Emollients in Hand Disinfectant Antimicrobial
Compositions
TABLE-US-00040 [0099] TABLE 4 Formulations containing various
emollients % w/w Ingredients A B C Benzyl alcohol 2.0 2.0 --
Benzethonium chloride 0.23 0.23 0.23 PHMB 0.4 0.4 0.4 Dipropylene
Glycol 5.0 5.0 5.0 Farnesol 2.0 -- 2.0 Zinc gluconate 0.2 0.2 0.2
Bisabolol 0.1 0.1 0.1 Aloe leaf juice 0.25 0.25 0.25 Pluronic F-87
prill 1.0 1.0 1.0 Methocel E4 M 0.2 0.2 0.2 PolyoxWSR 205 0.3 0.3
0.3 Incromine Oxide L 3.42 3.42 3.42 Montalene C 40 8.0 8.0 8.0
Water 57.3 59.3 59.3 Glycerine 1.0 1.0 1.0 SDA-40 B alcohol 14.0
14.0 14.0 Butylene glycol 1.0 1.0 1.0 Phenoxyethanol 1.0 1.0 1.0
Octanediol 1.0 1.0 1.0
Composition (A) was formulated with both benzyl alcohol and
farnesol; composition (B) was formulated with benzyl alcohol
without farnesol; and composition (C) was formulated with farnesol
without benzyl alcohol.
Method of Testing Substantive Activity
[0100] Pigskins (3 cm.sup.2 mounted on petri dishes) were washed
with non antibacterial soap and rinsed under running tap water. 3
pairs for control (Soap base) and 3 pairs for testing were used.
0.15 ml soap was added to each piece of the pair and rubbed for 30
seconds and each piece was rinsed with 75 ml water. After 1 or 2
hours, the pieces were contaminated with 10 .mu.l of 10.sup.5
Cfu/ml bacterial culture. After 15 minutes the pieces were rinsed
with 10 ml of drug inactivating fluid (DNF). The fluid was diluted
and plated on TSA. After incubation at 37.degree. C., the bacterial
counts were enumerated and the soap compositions were compared. The
results are shown in Table 5.
TABLE-US-00041 TABLE 5 Substantive antibacterial activity after one
time application of soap by pig skin method against, E. coli (ATCC
11229) Log.sub.10 reduction in colony-forming units SOAP from
control growth A 1.8 B 1.0 C 0.7
[0101] Conclusion: From the above results it is concluded that
farnesol and benzyl alcohol provide substantive antibacterial
efficacy. Dipropylene glycol acts to dissolve farnesol.
[0102] The effect of different sesquiterpenoids on substantive
antibacterial activity was also examined using the methods
described above. The sesquiterpenoids nerolidol, bisabolol and
apritone were examined using the formulations described below in
Table 6.
TABLE-US-00042 TABLE 6 % w/w Ingredients A B C D Benzyl alcohol 2.0
2.0 2.0 2.0 Benzethonium chloride 0.23 0.23 0.23 0.23 PHMB 0.4 0.4
0.4 0.4 Dipropylene Glycol 5.0 5.0 5.0 5.0 Farnesol 2.0 -- -- --
Nerolidol -- 2.0 -- -- Bisabolol -- -- 2.0 -- Apritone -- -- -- 2.0
Zinc gluconate 0.2 0.2 0.2 0.2 Bisabolol 0.1 0.1 0.1 0.1 Aloe leaf
juice 0.25 0.25 0.25 0.25 Pluronic F-87 prill 1.0 1.0 1.0 1.0
Methocel E4 M 0.2 0.2 0.2 0.2 PolyoxWSR 205 0.3 0.3 0.3 --
Incromine Oxide L 3.42 3.42 3.42 3.42 Montalene C 40 8.0 8.0 8.0
8.0 Water 57.3 57.3 57.3 57.3 Glycerine 1.0 1.0 1.0 1.0 SDA-40 B
alcohol 14.0 14.0 14.0 14.0 Butylene glycol 1.0 1.0 1.0 1.0
Phenoxyethanol 1.0 1.0 1.0 1.0 Octanediol 1.0 1.0 1.0 1.0
The antibacterial effects of the compositions described in Table 6
were tested using the pigskin assay method described above. The
results are shown below in Table 7.
TABLE-US-00043 TABLE 7 Substantive antibacterial activity with
various sesquiterpenoids against E. coli (ATCC 11229) Log.sub.10
reduction SOAP in colony-forming units, mean .+-. SD A 1.8 1 hour
post wash B 1.5 1 hour post wash C 1.6 1 hour post wash D 1.7 1
hour post wash
Conclusion: All the sesquiterpenoids tested have similar
substantive antibacterial efficacy.
9. EXAMPLE 5
Evaluation of Substantive Activity and Test Results of an
Antibacterial Soap Formulation (LPS 3, Described Above)
Method of Testing Substantive Activity
[0103] Pigskins (3 cm.sup.2 mounted on petri dishes) were washed
with non antibacterial soap and rinsed under running tap water. 3
pairs for control (Soap base) and 3 pairs for testing were used.
0.15 ml soap was added to each piece of the pair and rubbed for 30
seconds and each piece was rinsed with 75 ml water. After 1 or 2
Hour, the pieces were contaminated with 10 .mu.l of 10.sup.5 Cfu/ml
bacterial culture. After 15 minutes the pieces were rinsed with 10
ml of drug inactivating fluid (DNF). The fluid was diluted and
plated on TSA. After incubation at 37.degree. C., the bacterial
counts were enumerated and the effect of the three soaps were
compared.
The following formulations were tested: 1 DC (0.46% T): Commercial
soap containing 0.46% triclosan (T) (Dial). 2 TPB (0.15% T): Soap
containing 0.15% triclosan (T), PHMB and benzethonium chloride
without emollients. 3 LPS 3 Soap with emollients. The results are
described in Table 8.
TABLE-US-00044 TABLE 8 Antibacterial activity after a single one
time application of soap against S. aureus (ATCC 6538) and E. coli
(ATCC 11229) Log.sub.10 reduction in colony-forming units, mean
.+-. SD Pigskin Method SOAP S. aureus E. coli DC (0.46% T) 1 hour
post wash 0.58 .+-. 0.208 0.5 .+-. 0.12 2 hour post wash 0.17 .+-.
0.051 0.4 .+-. 0.10 TPB (0.15% T) 1 hour post wash 0.9 .+-. 0.21
0.7 .+-. 0.11 2 hour post wash 0.7 .+-. 0.18 0.7 .+-. 0.20 LPS-3 1
hour post wash 2.3 .+-. 0.26 1.8 .+-. 0.21 2 hour post wash 1.94
.+-. 0.27 1.9 .+-. 0.10 Control growth ranged from 1 .times.
10.sup.3 to 5 .times. 10.sup.3 cfu
Conclusion: Activity against both S aureus (Gram positive) and E.
coli (Gram negative) bacteria was seen even 2 hours after rinsing
skin that had been treated with the LPS 3 soap containing
emollients. The TPB soap, which contains antibacterial agents but
no emollients, did not exhibit any substantive antibacterial
activity against S. aureus and E. coli. Dial soap, which contains a
higher concentration of triclosan, also showed no significant
substantive antibacterial activity in this assay against S. aureus
and E. coli. The antibacterial efficacy of alcohol-free hand
sanitizer formulations was also examined using the methods
described above.
TABLE-US-00045 TABLE 9 Comparison of the substantive antibacterial
efficacy of alcohol-free hand sanitizers by pigskin method-C (Test
organism S. aureus) Log.sub.10 reduction from control counts
Disinfectant 1 hour post application 2 hour Post application AQ-D14
2.851 2.130 Lotion D-10 3.2 2.9 HSP 0.102 0.050 HSP: alcohol based
hand sanitizer Purell
Conclusion: Both of the AQ-D14 and Lotion D-10 alcohol-free hand
sanitizers show greater activity than the commercial alcohol-based
hand sanitizer tested.
[0104] Various patent and non-patent references are cited herein,
the contents of which are hereby incorporated by reference in their
entireties herein.
* * * * *