U.S. patent application number 14/155974 was filed with the patent office on 2014-08-21 for stabilized insulin-like growth factor polypeptides. This patent application is currently assigned to NOVARTIS AG. The applicant listed for this patent is Mara FORNARO, David Jonathan GLASS. Invention is credited to Mara FORNARO, David Jonathan GLASS.
Application Number | 20140235538 14/155974 |
Document ID | / |
Family ID | 38801859 |
Filed Date | 2014-08-21 |
United States Patent Application | 20140235538 |
Kind Code | A1 |
GLASS; David Jonathan ; et al. | August 21, 2014 |
The invention relates to stabilized polypeptides having an IGF-1 or IGF-2 sequence and an E-peptide sequence, where the natural physiological cleavage of the E-peptide from the IGF is prevented.
Inventors: | GLASS; David Jonathan; (Cortlandt Manor, NY) ; FORNARO; Mara; (Basel, CH) | ||||||||||
Applicant: |
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Assignee: | NOVARTIS AG Basel CH |
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Family ID: | 38801859 | ||||||||||
Appl. No.: | 14/155974 | ||||||||||
Filed: | January 15, 2014 |
Application Number | Filing Date | Patent Number | ||
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13664055 | Oct 30, 2012 | 8722621 | ||
14155974 | ||||
Current U.S. Class: | 514/6.9 ; 514/8.6; 530/324; 530/399; 536/23.5 |
Current CPC Class: | A61P 7/06 20180101; A61P 19/10 20180101; A61P 17/02 20180101; A61P 3/10 20180101; A61P 19/08 20180101; C07K 14/65 20130101; A61P 19/00 20180101; A61P 43/00 20180101; A61P 11/00 20180101; A61P 21/00 20180101; A61P 25/28 20180101; A61P 5/48 20180101; A61P 25/00 20180101; A61P 27/02 20180101; A61K 38/30 20130101; C07K 14/475 20130101 |
Class at Publication: | 514/6.9 ; 530/399; 514/8.6; 530/324; 536/23.5 |
International Class: | C07K 14/475 20060101 C07K014/475 |
Sequence CWU 1
1
184170PRTHomo sapiens 1Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg Arg Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg Ser Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 50 55 60 Lys Pro Ala
Lys Ser Ala 65 70 235PRTHomo sapiens 2Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Glu Val His Leu Lys
Asn Ala Ser Arg Gly Ser Ala Gly Asn Lys Asn 20 25 30 Tyr Arg Met 35
377PRTHomo sapiens 3Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro
Lys Thr Gln Lys 1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr
Lys Ser Gln Arg Arg Lys 20 25 30 Gly Trp Pro Lys Thr His Pro Gly
Gly Glu Gln Lys Glu Gly Thr Glu 35 40 45 Ala Ser Leu Gln Ile Arg
Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile 50 55 60 Gly Ser Arg Asn
Ala Glu Cys Arg Gly Lys Lys Gly Lys 65 70 75 440PRTHomo sapiens
4Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1
5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg
Lys 20 25 30 Gly Ser Thr Phe Glu Glu Arg Lys 35 40 5105PRTHomo
sapiens 5Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly
Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg
Leu Glu Met Tyr Cys Ala Pro Leu 50 55 60 Lys Pro Ala Lys Ser Ala
Arg Ser Val Arg Ala Gln Arg His Thr Asp 65 70 75 80 Met Pro Lys Thr
Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 85 90 95 Ser Ala
Gly Asn Lys Asn Tyr Arg Met 100 105 689PRTHomo sapiens 6Arg Asp Val
Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg 1 5 10 15 Tyr
Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr 20 25
30 Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly
35 40 45 His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys
Arg His 50 55 60 Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala
His Gly Gly Ala 65 70 75 80 Pro Pro Glu Met Ala Ser Asn Arg Lys 85
7159PRTHomo sapiens 7Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly
Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly
Phe Tyr Phe Ser Arg Pro Ala 20 25 30 Ser Arg Val Ser Arg Arg Ser
Arg Gly Ile Val Glu Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu
Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 50 55 60 Lys Ser Glu
Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 65 70 75 80 Phe
Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 85 90
95 Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala
100 105 110 Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg
Glu Ala 115 120 125 Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln
Asp Pro Ala His 130 135 140 Gly Gly Ala Pro Pro Glu Met Ala Ser Asn
Arg Lys Ala Tyr Arg 145 150 155 8100PRTHomo sapiens 8Thr Leu Cys
Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp
Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25
30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser
35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys
Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Thr Gln 65 70 75 80 Lys Glu Val His Leu Lys Asn Ala Ser Arg
Gly Ser Ala Gly Asn Lys 85 90 95 Asn Tyr Arg Met 100 9142PRTHomo
sapiens 9Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr Gln Pro
Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90 95 Lys Gly
Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr 100 105 110
Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu 115
120 125 Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 130
135 140 10104PRTHomo sapiens 10Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser
Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 65 70
75 80 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg
Lys 85 90 95 Gly Ser Thr Phe Glu Glu Arg Lys 100 11152PRTHomo
sapiens 11Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr Gln Pro
Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser Ala 85 90 95 Gly Asn
Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr 100 105 110
His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile 115
120 125 Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn
Ala 130 135 140 Glu Cys Arg Gly Lys Lys Gly Lys 145 150
12350PRTHomo sapiens 12Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Pro Gln Thr Gly Ile Val
Asp Glu Cys Cys Phe Arg Ser Cys Asp 35 40 45 Leu Arg Arg Leu Glu
Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys Ser 50 55 60 Ala Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr 65 70 75 80 Gln
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly 85 90
95 Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala
100 105 110 Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu
Ile Gly 115 120 125 Ser Arg Asn Ala Glu Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met 130 135 140 Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Thr Lys 145 150 155 160 Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr His Pro Gly Gly Glu Gln 165 170 175 Lys Glu Gly Thr Glu
Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu 180 185 190 Gln Arg Arg
Glu Ile Gly Ser Arg Asn Ala Glu Arg Ser Val Arg Ala 195 200 205 Gln
Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser 210 215
220 Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr
225 230 235 240 His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser
Leu Gln Ile 245 250 255 Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile
Gly Ser Arg Asn Ala 260 265 270 Glu Arg Ser Val Arg Ala Gln Arg His
Thr Asp Met Pro Lys Thr Gln 275 280 285 Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys Ser Gln Arg Arg 290 295 300 Lys Gly Trp Pro Lys
Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr 305 310 315 320 Glu Ala
Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu 325 330 335
Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340 345 350
13150PRTHomo sapiensmisc_feature(92)..(92)CARBOHYD 13Thr Leu Cys
Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp
Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25
30 Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp
35 40 45 Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala
Lys Ser 50 55 60 Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr Gln Lys Tyr 65 70 75 80 Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser
Arg Gly Ser Ala Gly Asn 85 90 95 Lys Asn Thr Lys Ser Gln Arg Arg
Lys Gly Trp Pro Lys Thr His Pro 100 105 110 Gly Gly Glu Gln Lys Glu
Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly 115 120 125 Lys Lys Lys Glu
Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys 130 135 140 Arg Gly
Lys Lys Gly Lys 145 150 14151PRTHomo sapiens 14Ala Tyr Arg Thr Leu
Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly
Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val 20 25 30 Ser
Arg Ala Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys 35 40
45 Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu
50 55 60 Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg
Tyr Pro 65 70 75 80 Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln
Ser Thr Gln Arg 85 90 95 Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg
Ala Arg Arg Gly His Val 100 105 110 Leu Ala Lys Glu Leu Glu Ala Phe
Arg Glu Ala Lys Arg His Arg Pro 115 120 125 Leu Ile Ala Leu Pro Thr
Gln Asp Pro Ala His Gly Gly Ala Pro Pro 130 135 140 Glu Met Ala Ser
Asn Arg Lys 145 150 15101PRTHomo sapiensMOD_RES(1)..(1)Any
non-natural amino acid that is pegylated 15Xaa Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg
Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45
Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50
55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr 65 70 75 80 Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser
Ala Gly Asn 85 90 95 Lys Asn Tyr Arg Met 100 16101PRTHomo sapiens
16Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1
5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser
Ser 20 25 30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys
Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala
Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Glu Val His Leu Lys
Asn Ala Ser Arg Gly Ser Ala Gly Asn 85 90 95 Lys Asn Tyr Arg Met
100 17101PRTHomo sapiens 17Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser
Ala Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80
Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn 85
90 95 Lys Asn Tyr Arg Met 100 18100PRTHomo sapiens 18Thr Leu Cys
Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp
Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25
30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser
35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys
Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Thr Gln 65 70 75 80 Lys Glu Val His Leu Lys Asn Ala Ser Arg
Gly Ser Ala Gly Asn Lys 85 90 95 Asn Tyr Arg Met 100 19101PRTHomo
sapiens 19Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Glu Val
His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn 85 90 95 Lys Asn
Tyr Arg Met 100 20101PRTHomo sapiens 20Thr Leu Cys Gly Ala Glu
Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe
Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala
Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45
Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50
55 60 Lys Ser Ala Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr 65 70 75 80 Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser
Ala Gly Asn 85 90 95 Lys Asn Tyr Arg Met 100 21100PRTHomo sapiens
21Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1
5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser
Ser 20 25 30 Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe
Arg Ser Cys 35 40 45 Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro
Leu Lys Pro Ala Lys 50 55 60 Ser Ala Ser Val Arg Ala Gln Arg His
Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Glu Val His Leu Lys Asn
Ala Ser Arg Gly Ser Ala Gly Asn Lys 85 90 95 Asn Tyr Arg Met 100
22100PRTHomo sapiens 22Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser Ala Arg
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys
Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn Lys 85 90
95 Asn Tyr Arg Met 100 2399PRTHomo sapiens 23Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg
Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40
45 Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys
50 55 60 Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr
Gln Lys 65 70 75 80 Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala
Gly Asn Lys Asn 85 90 95 Tyr Arg Met 24143PRTHomo sapiens 24Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20
25 30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg
Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu
Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg Ala Gln Arg His Thr
Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn
Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Trp Pro Lys Thr
His Pro Gly Gly Glu Gln Lys Glu Gly 100 105 110 Thr Glu Ala Ser Leu
Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg 115 120 125 Glu Ile Gly
Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135 140
25143PRTHomo sapiens 25Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro Gln Thr Gly
Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg
Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala
Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90
95 Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly
100 105 110 Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln
Arg Arg 115 120 125 Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys
Lys Gly Lys 130 135 140 26143PRTHomo sapiens 26Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg
Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40
45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala
50 55 60 Lys Ser Ala Ser Val Arg Ala Gln Arg His Thr Asp Met Pro
Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr
Lys Ser Gln Arg 85 90 95 Arg Lys Gly Trp Pro Lys Thr His Pro Gly
Gly Glu Gln Lys Glu Gly 100 105 110 Thr Glu Ala Ser Leu Gln Ile Arg
Gly Lys Lys Lys Glu Gln Arg Arg 115 120 125 Glu Ile Gly Ser Arg Asn
Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135 140 27143PRTHomo
sapiens 27Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Arg Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys
Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly 100 105 110
Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg 115
120 125 Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys
130 135 140 28142PRTHomo sapiens 28Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60
Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65
70 75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg Arg 85 90 95 Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln
Lys Glu Gly Thr 100 105 110 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys Glu Gln Arg Arg Glu 115 120 125 Ile Gly Ser Arg Asn Ala Glu Cys
Arg Gly Lys Lys Gly Lys 130 135 140 29142PRTHomo sapiens 29Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20
25 30 Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser
Cys 35 40 45 Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys
Pro Ala Lys 50 55 60 Ser Ala Ser Val Arg Ala Gln Arg His Thr Asp
Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys
Asn Thr Lys Ser Gln Arg Arg 85 90 95 Lys Gly Trp Pro Lys Thr His
Pro Gly Gly Glu Gln Lys Glu Gly Thr 100 105 110 Glu Ala Ser Leu Gln
Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu 115 120 125 Ile Gly Ser
Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135 140
30142PRTHomo sapiens 30Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser Ala Arg
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90
95 Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr
100 105 110 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg
Arg Glu 115 120 125 Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys
Gly Lys 130 135 140 31141PRTHomo sapiens 31Thr Leu Cys Gly Ala Glu
Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe
Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala
Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45
Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50
55 60 Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln
Lys 65 70 75 80 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg Arg Lys 85 90 95 Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln
Lys Glu Gly Thr Glu 100 105 110 Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys Glu Gln Arg Arg Glu Ile 115 120 125 Gly Ser Arg Asn Ala Glu Cys
Arg Gly Lys Lys Gly Lys 130 135 140 32106PRTHomo sapiens 32Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20
25 30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg
Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu
Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg Ala Gln Arg His Thr
Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn
Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Ser Thr Phe Glu
Glu Arg Lys 100 105 33106PRTHomo sapiens 33Thr Leu Cys Gly Ala Glu
Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe
Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg
Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45
Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50
55 60 Lys Ser Ala Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys
Ser Gln Arg 85 90 95 Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 100
105 34105PRTHomo sapiens 34Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser
Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85
90 95 Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105 35106PRTHomo
sapiens 35Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys
Gly Ser Thr Phe Glu Glu Arg Lys 100 105 36106PRTHomo sapiens 36Thr
Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10
15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser
20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe
Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro
Leu Lys Pro Ala 50 55 60 Lys Ser Ala Arg Val Arg Ala Gln Arg His
Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Ser Thr Phe
Glu Glu Arg Lys 100 105 37105PRTHomo sapiens 37Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg
Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40
45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala
50 55 60 Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr Gln 65 70 75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys
Ser Gln Arg Arg 85 90 95 Lys Gly Ser Thr Phe Glu Glu Arg Lys 100
105 38105PRTHomo sapiens 38Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr Gly
Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg Arg
Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser Ala
Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65
70 75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg Arg 85 90 95 Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105
39105PRTHomo sapiens 39Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser Ala Arg
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90
95 Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105 40153PRTHomo sapiens
40Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 1
5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser
Ser 20 25 30 Ala Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys
Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala
Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Ala Ser Arg Gly Ser 85 90 95 Ala Gly Asn Lys Asn
Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys 100 105 110 Thr His Pro
Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln 115 120 125 Ile
Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn 130 135
140 Ala Glu Cys Arg Gly Lys Lys Gly Lys 145 150 41153PRTHomo
sapiens 41Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Ser Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln
Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser 85 90 95 Ala Gly
Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys 100 105 110
Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln 115
120 125 Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg
Asn 130 135 140 Ala Glu Cys Arg Gly Lys Lys Gly Lys 145 150
42152PRTHomo sapiens 42Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser Ala Ser
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser Ala 85 90
95 Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr
100 105 110 His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu
Gln Ile 115 120 125 Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly
Ser Arg Asn Ala 130 135 140 Glu Cys Arg Gly Lys Lys Gly Lys 145 150
43153PRTHomo sapiens 43Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro Gln Thr Gly
Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg
Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala
Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser 85 90
95 Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys
100 105 110 Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser
Leu Gln 115 120 125 Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile
Gly Ser Arg Asn 130 135 140 Ala Glu Cys Arg Gly Lys Lys Gly Lys 145
150 44153PRTHomo sapiens 44Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser
Ala Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80
Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser 85
90 95 Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro
Lys 100 105 110 Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala
Ser Leu Gln 115 120 125 Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu
Ile Gly Ser Arg Asn 130 135 140 Ala Glu Cys Arg Gly Lys Lys Gly Lys
145 150 45152PRTHomo sapiens 45Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55 60 Ser
Ala Arg Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70
75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser
Ala 85 90 95 Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr 100 105 110 His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu
Ala Ser Leu Gln Ile 115 120 125 Arg Gly Lys Lys Lys Glu Gln Arg Arg
Glu Ile Gly Ser Arg Asn Ala 130 135 140 Glu Cys Arg Gly Lys Lys Gly
Lys 145 150 46152PRTHomo sapiens 46Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Ala Arg Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60
Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65
70 75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly
Ser Ala 85 90 95 Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly
Trp Pro Lys Thr 100 105 110 His Pro Gly Gly Glu Gln Lys Glu Gly Thr
Glu Ala Ser Leu Gln Ile 115 120 125 Arg Gly Lys Lys Lys Glu Gln Arg
Arg Glu Ile Gly Ser Arg Asn Ala 130 135 140 Glu Cys Arg Gly Lys Lys
Gly Lys 145 150 47151PRTHomo sapiens 47Thr Leu Cys Gly Ala Glu Leu
Val Asp Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr
Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 35 40 45 Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 50 55
60 Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys
65 70 75 80 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser
Ala Gly 85 90 95 Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr His 100 105 110 Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu
Ala Ser Leu Gln Ile Arg 115 120 125 Gly Lys Lys Lys Glu Gln Arg Arg
Glu Ile Gly Ser Arg Asn Ala Glu 130 135 140 Cys Arg Gly Lys Lys Gly
Lys 145 150 48101PRTHomo sapiens 48Gly Thr Leu Cys Gly Ala Glu Leu
Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr
Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala
Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys
Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60
Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65
70 75 80 Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala
Gly Asn 85 90 95 Lys Asn Tyr Arg Met 100 49143PRTHomo sapiens 49Gly
Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10
15 Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser
20 25 30 Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys
Phe Arg 35 40 45 Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala
Pro Leu Lys Pro 50 55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His
Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Trp Pro Lys
Thr His Pro Gly Gly Glu Gln Lys Glu Gly 100 105 110 Thr Glu Ala Ser
Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg 115 120 125 Glu Ile
Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135 140
50346PRTHomo sapiens 50Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu
Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro
Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly
Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg
Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90
95 Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr
100 105 110 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg
Arg Glu 115 120 125 Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg
His Thr Asp Met 130 135 140 Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Thr Lys 145 150 155 160 Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr His Pro Gly Gly Glu Gln 165 170 175 Lys Glu Gly Thr Glu
Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu 180 185 190 Gln Arg Arg
Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg 195 200 205 His
Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn 210 215
220 Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro
225 230 235 240 Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln
Ile Arg Gly 245 250 255 Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser
Arg Asn Ala Glu Val 260 265 270 Arg Ala Gln Arg His Thr Asp Met Pro
Lys Thr Gln Lys Tyr Gln Pro 275 280 285 Pro Ser Thr Asn Lys Asn Thr
Lys Ser Gln Arg Arg Lys Gly Trp Pro 290 295 300 Lys Thr His Pro Gly
Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu 305 310 315 320 Gln Ile
Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg 325 330 335
Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340 345 51347PRTHomo
sapiens 51Gly Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe
Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly
Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala Pro Gln Thr Gly Ile Val
Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys Asp Leu Arg Arg Leu Glu
Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60 Ala Lys Ser Ala Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys
Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly 100 105 110
Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg 115
120 125 Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg His Thr
Asp 130 135 140 Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn
Lys Asn Thr 145 150 155 160 Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys
Thr His Pro Gly Gly Glu 165 170 175 Gln Lys Glu Gly Thr Glu Ala Ser
Leu Gln Ile Arg Gly Lys Lys Lys 180 185 190 Glu Gln Arg Arg Glu Ile
Gly Ser Arg Asn Ala Glu Val Arg Ala Gln 195 200 205 Arg His Thr Asp
Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr 210 215 220 Asn Lys
Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His 225 230 235
240 Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg
245 250 255 Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn
Ala Glu 260 265 270 Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr
Gln Lys Tyr Gln 275 280 285 Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser
Gln Arg Arg Lys Gly Trp 290 295 300 Pro Lys Thr His Pro Gly Gly Glu
Gln Lys Glu Gly Thr Glu Ala Ser 305 310
315 320 Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly
Ser 325 330 335 Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340 345
52106PRTHomo sapiens 52Gly Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60 Ala Lys Ser
Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90
95 Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105 53102PRTHomo
sapiens 53Gly Pro Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln
Phe Val 1 5 10 15 Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr
Gly Tyr Gly Ser 20 25 30 Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys 50 55 60 Pro Ala Lys Ser Ala Val
Arg Ala Gln Arg His Thr Asp Met Pro Lys 65 70 75 80 Thr Gln Lys Glu
Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly 85 90 95 Asn Lys
Asn Tyr Arg Met 100 54144PRTHomo sapiens 54Gly Pro Thr Leu Cys Gly
Ala Glu Leu Val Asp Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp Arg
Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser Ser
Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40 45
Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 50
55 60 Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro
Lys 65 70 75 80 Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr
Lys Ser Gln 85 90 95 Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly
Gly Glu Gln Lys Glu 100 105 110 Gly Thr Glu Ala Ser Leu Gln Ile Arg
Gly Lys Lys Lys Glu Gln Arg 115 120 125 Arg Glu Ile Gly Ser Arg Asn
Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135 140 55346PRTHomo
sapiens 55Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr Gln Pro
Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90 95 Lys Gly
Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr 100 105 110
Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu 115
120 125 Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg His Thr Asp
Met 130 135 140 Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys
Asn Thr Lys 145 150 155 160 Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr
His Pro Gly Gly Glu Gln 165 170 175 Lys Glu Gly Thr Glu Ala Ser Leu
Gln Ile Arg Gly Lys Lys Lys Glu 180 185 190 Gln Arg Arg Glu Ile Gly
Ser Arg Asn Ala Glu Val Arg Ala Gln Arg 195 200 205 His Thr Asp Met
Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn 210 215 220 Lys Asn
Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro 225 230 235
240 Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly
245 250 255 Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala
Glu Val 260 265 270 Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln
Lys Tyr Gln Pro 275 280 285 Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg Arg Lys Gly Trp Pro 290 295 300 Lys Thr His Pro Gly Gly Glu Gln
Lys Glu Gly Thr Glu Ala Ser Leu 305 310 315 320 Gln Ile Arg Gly Lys
Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg 325 330 335 Asn Ala Glu
Cys Arg Gly Lys Lys Gly Lys 340 345 56348PRTHomo sapiens 56Gly Pro
Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val 1 5 10 15
Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser 20
25 30 Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys
Phe 35 40 45 Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala
Pro Leu Lys 50 55 60 Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His
Thr Asp Met Pro Lys 65 70 75 80 Thr Gln Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys Ser Gln 85 90 95 Arg Arg Lys Gly Trp Pro Lys
Thr His Pro Gly Gly Glu Gln Lys Glu 100 105 110 Gly Thr Glu Ala Ser
Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg 115 120 125 Arg Glu Ile
Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg His Thr 130 135 140 Asp
Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn 145 150
155 160 Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly
Gly 165 170 175 Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg
Gly Lys Lys 180 185 190 Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn
Ala Glu Val Arg Ala 195 200 205 Gln Arg His Thr Asp Met Pro Lys Thr
Gln Lys Tyr Gln Pro Pro Ser 210 215 220 Thr Asn Lys Asn Thr Lys Ser
Gln Arg Arg Lys Gly Trp Pro Lys Thr 225 230 235 240 His Pro Gly Gly
Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile 245 250 255 Arg Gly
Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala 260 265 270
Glu Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr 275
280 285 Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys
Gly 290 295 300 Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly
Thr Glu Ala 305 310 315 320 Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu
Gln Arg Arg Glu Ile Gly 325 330 335 Ser Arg Asn Ala Glu Cys Arg Gly
Lys Lys Gly Lys 340 345 57107PRTHomo sapiens 57Gly Pro Thr Leu Cys
Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp
Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser
Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40
45 Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys
50 55 60 Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys 65 70 75 80 Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn
Thr Lys Ser Gln 85 90 95 Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg
Lys 100 105 58102PRTHomo sapiens 58Gly Pro Thr Leu Cys Gly Ala Glu
Leu Val Asp Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp Arg Gly Phe
Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser Ser Arg Ala
Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40 45 Arg Ser
Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 50 55 60
Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys 65
70 75 80 Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser
Ala Gly 85 90 95 Asn Lys Asn Tyr Arg Met 100 59144PRTHomo sapiens
59Gly Pro Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val 1
5 10 15 Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly
Ser 20 25 30 Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu
Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr
Cys Ala Pro Leu Lys 50 55 60 Pro Ala Lys Ser Ala Val Arg Ala Gln
Arg His Thr Asp Met Pro Lys 65 70 75 80 Thr Gln Lys Tyr Gln Pro Pro
Ser Thr Asn Lys Asn Thr Lys Ser Gln 85 90 95 Arg Arg Lys Gly Trp
Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu 100 105 110 Gly Thr Glu
Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg 115 120 125 Arg
Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 130 135
140 60107PRTHomo sapiens 60Gly Pro Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser Ser Arg Ala Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 50 55 60 Pro Ala
Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys 65 70 75 80
Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln 85
90 95 Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105
61154PRTHomo sapiens 61Gly Pro Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser Ser Arg Ala Ala Pro Gln
Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu
Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 50 55 60 Pro Ala Lys
Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys 65 70 75 80 Thr
Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly 85 90
95 Ser Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro
100 105 110 Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala
Ser Leu 115 120 125 Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu
Ile Gly Ser Arg 130 135 140 Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys
145 150 62348PRTHomo sapiens 62Gly Pro Thr Leu Cys Gly Ala Glu Leu
Val Asp Ala Leu Gln Phe Val 1 5 10 15 Cys Gly Asp Arg Gly Phe Tyr
Phe Asn Lys Pro Thr Gly Tyr Gly Ser 20 25 30 Ser Ser Arg Ala Ala
Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 35 40 45 Arg Ser Cys
Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 50 55 60 Pro
Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys 65 70
75 80 Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser
Gln 85 90 95 Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu
Gln Lys Glu 100 105 110 Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys
Lys Lys Glu Gln Arg 115 120 125 Arg Glu Ile Gly Ser Arg Asn Ala Glu
Val Arg Ala Gln Arg His Thr 130 135 140 Asp Met Pro Lys Thr Gln Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn 145 150 155 160 Thr Lys Ser Gln
Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly 165 170 175 Glu Gln
Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys 180 185 190
Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala 195
200 205 Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro
Ser 210 215 220 Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr 225 230 235 240 His Pro Gly Gly Glu Gln Lys Glu Gly Thr
Glu Ala Ser Leu Gln Ile 245 250 255 Arg Gly Lys Lys Lys Glu Gln Arg
Arg Glu Ile Gly Ser Arg Asn Ala 260 265 270 Glu Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Thr Gln Lys Tyr 275 280 285 Gln Pro Pro Ser
Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly 290 295 300 Trp Pro
Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala 305 310 315
320 Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly
325 330 335 Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340 345
63103PRTHomo sapiens 63Gly Pro Ala Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg Ala Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg Ser Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 50 55 60 Lys Pro Ala
Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro 65 70 75 80 Lys
Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala 85 90
95 Gly Asn Lys Asn Tyr Arg Met 100 64145PRTHomo sapiens 64Gly Pro
Ala Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15
Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20
25 30 Ser Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys
Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys
Ala Pro Leu 50 55 60 Lys Pro Ala Lys Ser Ala Val Arg Ala Gln Arg
His Thr Asp Met Pro 65 70 75 80 Lys Thr Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Thr Lys Ser 85 90 95 Gln Arg Arg Lys Gly Trp Pro
Lys Thr His Pro Gly Gly Glu Gln Lys 100 105 110 Glu Gly Thr Glu Ala
Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu
Gln 115 120 125 Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly
Lys Lys Gly 130 135 140 Lys 145 65108PRTHomo sapiens 65Gly Pro Ala
Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val
Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20 25
30 Ser Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys
35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala
Pro Leu 50 55 60 Lys Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His
Thr Asp Met Pro 65 70 75 80 Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys Ser 85 90 95 Gln Arg Arg Lys Gly Ser Thr Phe
Glu Glu Arg Lys 100 105 66155PRTHomo sapiens 66Gly Pro Ala Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser
Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40
45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu
50 55 60 Lys Pro Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp
Met Pro 65 70 75 80 Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys
Asn Ala Ser Arg 85 90 95 Gly Ser Ala Gly Asn Lys Asn Thr Lys Ser
Gln Arg Arg Lys Gly Trp 100 105 110 Pro Lys Thr His Pro Gly Gly Glu
Gln Lys Glu Gly Thr Glu Ala Ser 115 120 125 Leu Gln Ile Arg Gly Lys
Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser 130 135 140 Arg Asn Ala Glu
Cys Arg Gly Lys Lys Gly Lys 145 150 155 67349PRTHomo sapiens 67Gly
Pro Ala Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10
15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly
20 25 30 Ser Ser Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu
Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr
Cys Ala Pro Leu 50 55 60 Lys Pro Ala Lys Ser Ala Val Arg Ala Gln
Arg His Thr Asp Met Pro 65 70 75 80 Lys Thr Gln Lys Tyr Gln Pro Pro
Ser Thr Asn Lys Asn Thr Lys Ser 85 90 95 Gln Arg Arg Lys Gly Trp
Pro Lys Thr His Pro Gly Gly Glu Gln Lys 100 105 110 Glu Gly Thr Glu
Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln 115 120 125 Arg Arg
Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg His 130 135 140
Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys 145
150 155 160 Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His
Pro Gly 165 170 175 Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln
Ile Arg Gly Lys 180 185 190 Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser
Arg Asn Ala Glu Val Arg 195 200 205 Ala Gln Arg His Thr Asp Met Pro
Lys Thr Gln Lys Tyr Gln Pro Pro 210 215 220 Ser Thr Asn Lys Asn Thr
Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys 225 230 235 240 Thr His Pro
Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln 245 250 255 Ile
Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn 260 265
270 Ala Glu Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys
275 280 285 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg
Arg Lys 290 295 300 Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys
Glu Gly Thr Glu 305 310 315 320 Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys Glu Gln Arg Arg Glu Ile 325 330 335 Gly Ser Arg Asn Ala Glu Cys
Arg Gly Lys Lys Gly Lys 340 345 68101PRTHomo sapiens 68Gly Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25
30 Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg
35 40 45 Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu
Lys Pro 50 55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp
Met Pro Lys Thr 65 70 75 80 Gln Lys Glu Val His Leu Lys Asn Ala Ser
Arg Gly Ser Ala Gly Asn 85 90 95 Lys Asn Tyr Arg Met 100
69143PRTHomo sapiens 69Gly Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60 Ala Lys Ser
Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90
95 Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly
100 105 110 Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln
Arg Arg 115 120 125 Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys
Lys Gly Lys 130 135 140 70153PRTHomo sapiens 70Gly Thr Leu Cys Gly
Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg
Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser
Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40
45 Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro
50 55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro
Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala
Ser Arg Gly Ser 85 90 95 Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg
Arg Lys Gly Trp Pro Lys 100 105 110 Thr His Pro Gly Gly Glu Gln Lys
Glu Gly Thr Glu Ala Ser Leu Gln 115 120 125 Ile Arg Gly Lys Lys Lys
Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn 130 135 140 Ala Glu Cys Arg
Gly Lys Lys Gly Lys 145 150 71347PRTHomo sapiens 71Gly Thr Leu Cys
Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp
Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30
Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35
40 45 Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys
Pro 50 55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn
Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Trp Pro Lys Thr His Pro
Gly Gly Glu Gln Lys Glu Gly 100 105 110 Thr Glu Ala Ser Leu Gln Ile
Arg Gly Lys Lys Lys Glu Gln Arg Arg 115 120 125 Glu Ile Gly Ser Arg
Asn Ala Glu Val Arg Ala Gln Arg His Thr Asp 130 135 140 Met Pro Lys
Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 145 150 155 160
Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 165
170 175 Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys 180 185 190 Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Val
Arg Ala Gln 195 200 205 Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr
Gln Pro Pro Ser Thr 210 215 220 Asn Lys Asn Thr Lys Ser Gln Arg Arg
Lys Gly Trp Pro Lys Thr His 225 230 235 240 Pro Gly Gly Glu Gln Lys
Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg 245 250 255 Gly Lys Lys Lys
Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu 260 265 270 Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln 275 280 285
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp 290
295 300 Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala
Ser 305 310 315 320 Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg
Glu Ile Gly Ser 325 330 335 Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly
Lys 340 345 72143PRTHomo sapiensMOD_RES(1)..(1)Any non-natural
amino acid that is pegylated 72Xaa Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr Phe
Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala Pro
Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys Asp
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60 Ala
Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70
75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg 85 90 95 Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln
Lys Glu Gly 100 105 110 Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys Glu Gln Arg Arg 115 120 125 Glu Ile Gly Ser Arg Asn Ala Glu Cys
Arg Gly Lys Lys Gly Lys 130 135 140 73106PRTHomo
sapiensMOD_RES(1)..(1)Any non-natural amino acid that is pegylated
73Xaa Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1
5 10 15 Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser
Ser 20 25 30 Ser Arg Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys
Cys Phe Arg 35 40 45 Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys
Ala Pro Leu Lys Pro 50 55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys Gly Ser Thr
Phe Glu Glu Arg Lys 100 105 74153PRTHomo sapiensMOD_RES(1)..(1)Any
non-natural amino acid that is pegylated 74Xaa Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg
Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45
Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50
55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser
Arg Gly Ser 85 90 95 Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg
Lys Gly Trp Pro Lys 100 105 110 Thr His Pro Gly Gly Glu Gln Lys Glu
Gly Thr Glu Ala Ser Leu Gln 115 120 125 Ile Arg Gly Lys Lys Lys Glu
Gln Arg Arg Glu Ile Gly Ser Arg Asn 130 135 140 Ala Glu Cys Arg Gly
Lys Lys Gly Lys 145 150 75347PRTHomo sapiensMOD_RES(1)..(1)Any
non-natural amino acid that is pegylated 75Xaa Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly
Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg
Ala Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45
Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50
55 60 Ala Lys Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr 65 70 75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys
Ser Gln Arg 85 90 95 Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly
Glu Gln Lys Glu Gly 100 105 110 Thr Glu Ala Ser Leu Gln Ile Arg Gly
Lys Lys Lys Glu Gln Arg Arg 115 120 125 Glu Ile Gly Ser Arg Asn Ala
Glu Val Arg Ala Gln Arg His Thr Asp 130 135 140 Met Pro Lys Thr Gln
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 145 150 155 160 Lys Ser
Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 165 170 175
Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 180
185 190 Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala
Gln 195 200 205 Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro
Pro Ser Thr 210 215 220 Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly
Trp Pro Lys Thr His 225 230 235 240 Pro Gly Gly Glu Gln Lys Glu Gly
Thr Glu Ala Ser Leu Gln Ile Arg 245 250 255 Gly Lys Lys Lys Glu Gln
Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu 260 265 270 Val Arg Ala Gln
Arg His Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln 275 280 285 Pro Pro
Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp 290 295 300
Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser 305
310 315 320 Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile
Gly Ser 325 330 335 Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340
345 76101PRTHomo sapiensMOD_RES(68)..(68)Any non-natural amino acid
that is pegylated 76Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln
Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr
Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Xaa
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys
Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn
85 90 95 Lys Asn Tyr Arg Met 100 77143PRTHomo
sapiensMOD_RES(68)..(68)Any non-natural amino acid that is
pegylated 77Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Xaa Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys Tyr Gln
Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95 Arg Lys
Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly 100 105 110
Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg 115
120 125 Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys
130 135 140 78106PRTHomo sapiensMOD_RES(68)..(68)Any non-natural
amino acid that is pegylated 78Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln
Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu
Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys
Ser Ala Xaa Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70
75 80 Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln
Arg 85 90 95 Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105
79153PRTHomo sapiensMOD_RES(68)..(68)Any non-natural amino acid
that is pegylated 79Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln
Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr
Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Xaa
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser 85 90 95
Ala Gly Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys 100
105 110 Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu
Gln 115 120 125 Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly
Ser Arg Asn 130 135 140 Ala Glu Cys Arg Gly Lys Lys Gly Lys 145 150
80347PRTHomo sapiensMOD_RES(66)..(66)Any non-natural amino acid
that is pegylated 80Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln
Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr
Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Xaa Ser Ala
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80 Gln Lys
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85 90 95
Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly 100
105 110 Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg
Arg 115 120 125 Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg
His Thr Asp 130 135 140 Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser
Thr Asn Lys Asn Thr 145 150 155 160 Lys Ser Gln Arg Arg Lys Gly Trp
Pro Lys Thr His Pro Gly Gly Glu 165 170 175 Gln Lys Glu Gly Thr Glu
Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 180 185 190 Glu Gln Arg Arg
Glu Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln 195 200 205 Arg His
Thr Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr 210 215 220
Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His 225
230 235 240 Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln
Ile Arg 245 250 255 Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser
Arg Asn Ala Glu 260 265 270 Val Arg Ala Gln Arg His Thr Asp Met Pro
Lys Thr Gln Lys Tyr Gln 275 280 285 Pro Pro Ser Thr Asn Lys Asn Thr
Lys Ser Gln Arg Arg Lys Gly Trp 290 295 300 Pro Lys Thr His Pro Gly
Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser 305 310 315 320 Leu Gln Ile
Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser 325 330 335 Arg
Asn Ala Glu Cys Arg Gly Lys Lys Gly Lys 340 345 81100PRTHomo
sapiensMOD_RES(87)..(87)Any non-natural amino acid that is
pegylated 81Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Glu Val His
Leu Lys Xaa Ala Ser Arg Gly Ser Ala Gly Asn Lys 85 90 95 Asn Tyr
Arg Met 100 82142PRTHomo sapiensMOD_RES(136)..(136)Any non-natural
amino acid that is pegylated 82Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln
Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu
Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys
Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70
75 80 Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg
Arg 85 90 95 Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys
Glu Gly Thr 100 105 110 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys
Glu Gln Arg Arg Glu 115 120 125 Ile Gly Ser Arg Asn Ala Glu Xaa Arg
Gly Lys Lys Gly Lys 130 135 140 83152PRTHomo
sapiensMOD_RES(146)..(146)Any non-natural amino acid that is
pegylated 83Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val
Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr Gln Pro
Pro Ser Thr Asn Lys Asn Ala Ser Arg Gly Ser Ala 85 90 95 Gly Asn
Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr 100 105 110
His Pro Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile 115
120 125 Arg Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn
Ala 130 135 140 Glu Xaa Arg Gly Lys Lys Gly Lys 145 150
84346PRTHomo sapiensMOD_RES(340)..(340)Any non-natural amino acid
that is pegylated 84Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln
Phe Val Cys Gly 1 5 10 15 Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr
Gly Tyr Gly Ser Ser Ser 20 25 30 Arg Ala Ala Pro Gln Thr Gly Ile
Val Asp Glu Cys Cys Phe Arg Ser 35 40 45 Cys Asp Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 50 55 60 Lys Ser Ala Val
Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln 65 70 75 80 Lys Tyr
Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg 85 90 95
Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu Gly Thr 100
105 110 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu Gln Arg Arg
Glu 115 120 125 Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg His
Thr Asp Met 130 135 140 Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr
Asn Lys Asn Thr Lys 145 150 155 160 Ser Gln Arg Arg Lys Gly Trp Pro
Lys Thr His Pro Gly Gly Glu Gln 165 170 175 Lys Glu Gly Thr Glu Ala
Ser Leu Gln Ile Arg Gly Lys Lys Lys Glu 180 185 190 Gln Arg Arg Glu
Ile Gly Ser Arg Asn Ala Glu Val Arg Ala Gln Arg 195 200 205 His Thr
Asp Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn 210 215 220
Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro 225
230 235 240 Gly Gly Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile
Arg Gly 245 250 255 Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg
Asn Ala Glu Val 260 265 270 Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr Gln Lys Tyr Gln Pro 275 280 285 Pro Ser Thr Asn Lys Asn Thr Lys
Ser Gln Arg Arg Lys Gly Trp Pro 290 295 300 Lys Thr His Pro Gly Gly
Glu Gln Lys Glu Gly Thr Glu Ala Ser Leu 305 310 315 320 Gln Ile Arg
Gly Lys Lys Lys Glu Gln Arg Arg Glu Ile Gly Ser Arg 325 330 335 Asn
Ala Glu Xaa Arg Gly Lys Lys Gly Lys 340 345 8570PRTOvis aries 85Gly
Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10
15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly
20 25 30 Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu
Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr
Cys Ala Pro Leu 50 55 60 Lys Ala Ala Lys Ser Ala 65 70 8661PRTOvis
aries 86Leu Val Asp Ala Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr
Phe 1 5 10 15 Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala
Pro Gln Thr 20 25 30 Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys
Asp Leu Arg Arg Leu 35 40 45 Glu Met Tyr Cys Ala Pro Leu Lys Ala
Ala Lys Ser Ala 50 55 60 8770PRTCapra hircus 87Gly Pro Glu Thr Leu
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly
Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser
Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40
45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu
50 55 60 Lys Pro Thr Lys Ser Ala 65 70 8870PRTAiluropoda
melanoleuca 88Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala
Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys
Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg Arg Ala Pro Gln Thr
Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg
Arg Leu Glu Met Tyr Cys Ala Pro Leu 50 55 60 Lys Pro Ala Lys Ser
Ala 65 70 8970PRTCervus elaphus 89Gly Pro Glu Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly
Ser Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg
Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg
Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 50 55 60
Lys Pro Thr Lys Ala Ala 65 70 9070PRTOryctolagus cuniculus 90Gly
Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10
15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly
20 25 30 Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu
Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr
Cys Ala Pro Leu 50 55 60 Lys Pro Ala Lys Ala Ala 65 70
9170PRTRattus norvegicus 91Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu
Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Pro Arg Gly Phe Tyr
Phe Asn Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ile Arg Arg Ala
Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg Ser Cys
Asp Leu Arg Arg Leu Glu Met Tyr Cys Val Arg Cys 50 55 60 Lys Pro
Thr Lys Ser Ala 65 70 9270PRTRattus norvegicus 92Gly Pro Glu Thr
Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys
Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20 25 30
Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 35
40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro
Leu 50 55 60 Lys Pro Thr Lys Ser Ala 65 70 9370PRTMus musculus
93Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 1
5 10 15 Val Cys Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr
Gly 20 25 30 Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val Asp
Glu Cys Cys 35 40 45 Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met
Tyr Cys Ala Pro Leu 50 55 60 Lys Pro Thr Lys Ala Ala 65 70
9470PRTAnser anser 94Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val
Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe
Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg Arg Leu His
His Lys Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Gln Ser Cys Asp
Leu Arg Arg Leu
Glu Met Tyr Cys Ala Pro Ile 50 55 60 Lys Pro Pro Lys Ser Ala 65 70
9570PRTOncorhynchus tshawytscha 95Gly Pro Glu Thr Leu Cys Gly Ala
Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Glu Arg Gly
Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Ser Ser Arg
Arg Ser His Asn Arg Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Gln
Ser Cys Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Val 50 55 60
Lys Ser Gly Lys Ala Ala 65 70 9670PRTAcipenser ruthenus 96Gly Ser
Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15
Val Cys Gly Glu Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 20
25 30 Ala Ser Ser Arg Arg Pro His His Arg Gly Ile Val Asn Glu Cys
Cys 35 40 45 Phe Gln Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys
Ala Pro Val 50 55 60 Lys Pro Ala Lys Ala Ser 65 70
9768PRTParalichthys olivaceus 97Gly Pro Glu Thr Leu Cys Gly Ala Glu
Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Glu Arg Gly Phe
Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Asn Ala Arg Arg
Ser Arg Gly Ile Val Asp Glu Cys Cys Phe Gln 35 40 45 Ser Cys Glu
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Ala Lys Thr 50 55 60 Ser
Lys Ala Ala 65 9870PRTOncorhynchus mykiss 98Gly Pro Glu Thr Leu Cys
Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Glu
Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Ser
Ser Arg Arg Ser His Asn Arg Gly Ile Val Asp Glu Cys Cys 35 40 45
Phe Gln Ser Cys Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Val 50
55 60 Lys Ser Gly Lys Ala Ala 65 70 9970PRTIctalurus punctatus
99Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1
5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly Tyr
Gly 20 25 30 Pro Asn Ser Arg Arg Leu His Asn Arg Gly Ile Val Asp
Glu Cys Cys 35 40 45 Phe Gln Ser Cys Glu Leu Lys Arg Leu Glu Met
Tyr Cys Ala Pro Val 50 55 60 Lys Ser Gly Lys Ala Pro 65 70
10070PRTCyprinus carpio 100Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu
Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr
Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Ser Ser Arg Arg Ser
His Asn Arg Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Gln Ser Cys
Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Val 50 55 60 Lys Pro
Gly Lys Thr Pro 65 70 10170PRTCyprinus carpio 101Gly Pro Glu Thr
Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys
Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30
Pro Ser Ser Arg Arg Ser His Asn Arg Gly Ile Val Asp Glu Cys Cys 35
40 45 Phe Gln Ser Cys Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro
Val 50 55 60 Lys Thr Gly Lys Thr Pro 65 70 10270PRTDanio rerio
102Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe
1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly
Tyr Gly 20 25 30 Pro Ser Ser Arg Arg Ser His Asn Arg Gly Ile Val
Asp Glu Cys Cys 35 40 45 Phe Gln Ser Cys Glu Leu Arg Arg Leu Glu
Met Tyr Cys Ala Pro Val 50 55 60 Lys Thr Gly Lys Ser Pro 65 70
10370PRTMyxocyprinus asiaticus 103Gly Pro Glu Thr Leu Cys Gly Ala
Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly
Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Ser Ser Arg
Arg Ser His Asn Arg Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Gln
Ser Cys Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Val 50 55 60
Lys Pro Gly Lys Ala Pro 65 70 10470PRTPimephales promelas 104Gly
Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1 5 10
15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Ala Gly Tyr Gly
20 25 30 Ser Asn Ser Arg Arg Ser Asn Asn Tyr Gly Ile Val Asp Glu
Cys Cys 35 40 45 Phe Gln Ser Cys Glu Leu Arg Arg Leu Glu Met Tyr
Cys Ala Pro Val 50 55 60 Lys Thr Gly Lys Thr Pro 65 70
10570PRTCarassius auratus 105Gly Pro Glu Thr Leu Cys Gly Ala Glu
Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys Gly Asp Arg Gly Phe
Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Pro Asn Ser Arg Arg
Ser His Asn Arg Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Gln Ser
Cys Glu Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Val 50 55 60 Lys
Pro Gly Lys Thr Pro 65 70 10670PRTXenopus laevis 106Gly Pro Glu Thr
Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe 1 5 10 15 Val Cys
Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30
Ser Asn Asn Arg Arg Ser His His Arg Gly Ile Val Asp Glu Cys Cys 35
40 45 Phe Gln Ser Cys Asp Phe Arg Arg Leu Glu Met Tyr Cys Ala Pro
Ala 50 55 60 Lys Pro Ala Lys Ser Ala 65 70 10770PRTXenopus laevis
107Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe
1 5 10 15 Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly
Tyr Gly 20 25 30 Ser Asn Asn Arg Arg Ser His His Arg Gly Ile Val
Asp Glu Cys Cys 35 40 45 Phe Gln Ser Cys Asp Phe Arg Arg Leu Glu
Met Tyr Cys Ala Pro Ala 50 55 60 Lys Gln Ala Lys Ser Ala 65 70
10870PRTMonodelphis domestica 108Gly Pro Glu Thr Leu Cys Gly Ala
Glu Leu Val Asp Ala Leu Gln Phe 1 5 10 15 Val Cys Gly Glu Arg Gly
Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 20 25 30 Ser Ser Ser Arg
Arg Leu His His Thr Gly Ile Val Asp Glu Cys Cys 35 40 45 Phe Arg
Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Ile 50 55 60
Lys Pro Ala Lys Ser Ala 65 70 10935PRTSus scrofa 109Arg Ser Val Arg
Ala Gln Arg His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Val
His Leu Lys Asn Thr Ser Arg Gly Ser Ser Gly Asn Lys Asn 20 25 30
Tyr Arg Met 35 11035PRTSus scrofa 110Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Ala Arg Lys 1 5 10 15 Glu Val His Leu Lys
Asn Thr Ser Arg Gly Ser Ser Gly Asn Lys Asn 20 25 30 Tyr Arg Met 35
11135PRTBos taurus 111Arg Ser Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Leu Lys Asn Thr Ser Arg
Gly Ser Ala Gly Asn Lys Asn 20 25 30 Tyr Arg Met 35 11233PRTCanis
familiaris 112Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Ala Gln Lys 1 5 10 15 Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser
Ala Gly Asn Lys Thr 20 25 30 Tyr 11335PRTCanis familiaris 113Arg
Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10
15 Glu Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn Lys Asn
20 25 30 Tyr Arg Met 35 11435PRTOryctolagus cuniculus 114Arg Ser
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15
Glu Val His Leu Lys Asn Thr Ser Arg Gly Ser Ala Gly Asn Lys Asn 20
25 30 Tyr Arg Met 35 11535PRTRattus norvegicus 115Arg Ser Ile Arg
Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Glu Val
His Leu Lys Asn Thr Ser Arg Gly Ser Ala Gly Asn Lys Thr 20 25 30
Tyr Arg Met 35 11635PRTGallus gallus 116Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Leu Lys
Asn Thr Ser Arg Gly Asn Thr Gly Asn Arg Asn 20 25 30 Tyr Arg Met 35
11735PRTMeleagris gallopavo 117Arg Ser Val Arg Ala Gln Arg His Thr
Asp Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Leu His Leu Lys Asn Thr
Ser Arg Gly Asn Thr Gly Asn Arg Asn 20 25 30 Tyr Arg Met 35
11830PRTAnser anser 118Arg Ser Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Leu Lys Asn Thr Ser Arg
Gly Asn Thr Glu Asn 20 25 30 11935PRTOncorhynchus tshawytscha
119Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Arg Thr Pro Lys
1 5 10 15 Glu Val His Gln Lys Asn Ser Ser Arg Gly Asn Thr Gly Gly
Arg Asn 20 25 30 Tyr Arg Met 35 12035PRTAcipenser ruthenus 120Arg
Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10
15 Glu Val His Ser Lys Asn Ser Ser Arg Gly Asn Thr Gly Asn Arg Asn
20 25 30 Tyr Arg Ile 35 12135PRTPerca fluviatilis 121Arg Ser Val
Arg Ala Gln Arg His Thr Asp Met Pro Arg Ala Pro Lys 1 5 10 15 Glu
Val His Gln Lys Asn Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25
30 Tyr Arg Met 35 12235PRTParalichthys olivaceus 122Arg Ser Val Arg
Ala Gln Arg His Thr Asp Met Pro Arg Ala Pro Lys 1 5 10 15 Glu Val
His Gln Lys Asn Ser Ser Arg Gly Thr Thr Gly Gly Arg Asn 20 25 30
Tyr Arg Met 35 12335PRTIctalurus punctatus 123Arg Ser Val Arg Glu
Gln Arg His Thr Asp Thr Pro Lys Thr Pro Lys 1 5 10 15 Glu Val His
Gln Lys Asn Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr
Arg Met 35 12435PRTCirrhinus molitorella 124Arg Ser Ile Arg Ala Gln
Arg His Thr Asp Ser Pro Lys Thr Ala Lys 1 5 10 15 Glu Val His Gln
Lys Asn Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg
Met 35 12535PRTCirrhinus molitorella 125Arg Ser Val Arg Ala Gln Arg
His Thr Asp Ser Pro Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys
Asn Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Ile 35
12635PRTDevario aequipinnatus 126Arg Ser Leu Arg Ala Gln Arg His
Thr Asp Ile Pro Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys Asn
Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Met 35
12735PRTDanio rerio 127Arg Ser Leu Arg Ala Gln Arg His Thr Asp Ile
Pro Arg Thr Pro Lys 1 5 10 15 Glu Val His Gln Lys Asn Ser Ser Arg
Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Met 35
12835PRTMyxocyprinus asiaticus 128Arg Ser Leu Arg Ala Gln Arg His
Thr Asp Ile Pro Arg Thr Pro Lys 1 5 10 15 Asp Val His Gln Lys Asn
Ser Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Met 35
12935PRTBarbus barbus 129Arg Ser Leu Arg Ala Gln Arg His Thr Asp
Ser Pro Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys Asn Ser Ser
Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Ile 35
13035PRTPimephales promelas 130Arg Ser Leu Arg Ala Gln Arg His Thr
Asp Ile Thr Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys Asn Ser
Ser Arg Gly Ile Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Met 35
13135PRTCarassius auratus 131Arg Ser Leu Arg Ala Gln Arg His Thr
Asp Gly Thr Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys Asn Ser
Ser Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Met 35
13235PRTXenopus laevis 132Arg Ser Val Arg Ala Gln Arg His Thr Asp
Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Pro Lys Asn Thr Ser
Arg Gly Asn Thr Gly Ser Arg Gly 20 25 30 Phe Arg Met 35
13335PRTKuhlia rupestris 133Arg Ser Leu Arg Ala Gln Arg His Thr Asp
Ile Thr Arg Thr Ala Lys 1 5 10 15 Glu Val His Gln Lys Asn Ser Ser
Arg Gly Asn Thr Gly Gly Arg Asn 20 25 30 Tyr Arg Ile 35
13435PRTXenopus laevis 134Arg Ser Val Arg Thr Gln Arg His Thr Asp
Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Pro Lys Asn Thr Ser
Arg Gly Asn Thr Gly Ser Arg Gly 20 25 30 Phe Arg Met 35
13546PRTArtificial SequenceDescription of Artificial Sequence
Synthetic majority consensus polypeptide 135Arg Ser Val Arg Ala Gln
Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Tyr Gln Pro Pro
Ser Thr Asn Lys Lys Thr Lys Ser Gln Arg Arg Arg 20 25 30 Lys Gly
Gly Pro Lys Thr His Pro Gly Gly Glu Gln Lys Glu 35 40 45
13641PRTSus scrofa 136Arg Ser Val Arg Ala Gln Arg His Thr Asp Met
Pro Lys Ala Gln Lys 1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Lys
Thr Lys Ser Gln Arg Arg Arg 20 25 30 Lys Gly Ser Thr Phe Glu Glu
His Lys 35 40 13730PRTBos indicus 137Tyr Gln Pro Pro Ser Thr Asn
Lys Lys Met Lys Ser Gln Arg Arg Arg 1 5 10 15 Lys Gly Gly Pro Lys
Lys Arg Pro Gly Gly Glu Gln Lys Glu 20 25 30 13850PRTBos taurus
138His Ala Gln Gly Ser Glu Gly Lys Pro Ala Arg Gly Gly Gly Glu Gly
1 5 10 15 Arg Pro Ser Ser Tyr Gln Pro Pro Ser Thr Asn Lys Lys Met
Lys Ser 20 25 30 Gln Arg Arg Arg Lys Gly Gly Pro Lys Lys Arg Pro
Gly Gly Glu Gln 35 40 45 Lys Glu 50 13930PRTBubalus bubalis 139Tyr
Gln Pro Pro Ser Thr Asn Lys Lys Met Lys Ser Gln Arg Arg Arg 1 5 10
15 Lys Gly Gly Pro Lys Lys His Pro Gly Gly Glu Gln Lys Glu 20 25 30
14030PRTOvis aries 140Tyr Gln Leu Pro Ser Thr Asn Lys Lys Met Lys
Ser Gln Arg Arg Arg 1 5 10 15 Lys Gly Gly Pro Lys Lys His Pro Gly
Gly Glu Gln Lys Glu
20 25 30 14141PRTCanis familiaris 141Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10 15 Tyr His Pro Pro Ser
Thr Thr Lys Arg Met Lys Ser Gln Arg Arg Arg 20 25 30 Lys Gly Ser
Thr Phe Glu Glu Cys Lys 35 40 14241PRTOryctolagus cuniculus 142Arg
Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10
15 Tyr Gln Pro Pro Ser Thr Asn Lys Lys Met Lys Ser Gln Arg Arg Arg
20 25 30 Lys Gly Ser Thr Phe Glu Glu His Lys 35 40 14378PRTPan
troglodytes 143Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys
Thr Gln Lys 1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys
Ser Gln Arg Arg Arg 20 25 30 Lys Gly Gly Pro Lys Thr His Pro Gly
Gly Glu Gln Lys Glu Gly Thr 35 40 45 Glu Ala Ser Leu Gln Ile Arg
Gly Lys Lys Lys Glu Gln Arg Arg Glu 50 55 60 Ile Gly Ser Arg Asn
Ala Glu Cys Arg Gly Lys Lys Gly Lys 65 70 75 14490PRTMacaca mulatta
144Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys
1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg
Arg Arg 20 25 30 Lys Gly Gly Pro Lys Thr His Pro Gly Gly Glu Gln
Lys Glu Gly Thr 35 40 45 Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys
Lys Glu Gln Arg Arg Glu 50 55 60 Ile Gly Ser Arg Asn Ala Glu Cys
Arg Gly Lys Lys Gly Lys Trp Arg 65 70 75 80 Thr Gly Gly Leu Ser Arg
Gln Arg Gln Gly 85 90 14563PRTMus musculus 145Arg Ser Ile Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Ser Pro Ser
Leu Ser Thr Asn Lys Lys Thr Lys Leu Gln Arg Arg Arg 20 25 30 Lys
Gly Glu Pro Lys Thr His Pro Glu Gly Glu Gln Glu Glu Val Thr 35 40
45 Glu Ala Thr Arg Lys Ile Arg Gly Pro Arg Glu Lys Arg Leu Gly 50
55 60 14663PRTRattus norvegicus 146Arg Ser Ile Arg Ala Gln Arg His
Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Ser Gln Pro Leu Ser Thr
His Lys Lys Arg Lys Leu Gln Arg Arg Arg 20 25 30 Lys Gly Glu Ser
Lys Ala His Pro Gly Gly Glu Gln Glu Glu Gly Ala 35 40 45 Glu Ala
Thr Gln Lys Ile Arg Gly Asp Arg Glu Arg Arg Pro Ser 50 55 60
14741PRTMus musculus 147Arg Ser Ile Arg Ala Gln Arg His Thr Asp Met
Pro Lys Thr Gln Lys 1 5 10 15 Ser Pro Ser Leu Ser Thr Asn Lys Lys
Thr Lys Leu Gln Arg Arg Arg 20 25 30 Lys Gly Ser Thr Phe Glu Glu
His Lys 35 40 14840PRTArtificial SequenceDescription of Artificial
Sequence Synthetic majority consensus polypeptide 148Arg Ser Val
Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Tyr
Gln Pro Pro Ser Thr Asn Lys Lys Thr Lys Ser Gln Arg Arg Arg 20 25
30 Lys Gly Ser Thr Phe Glu Glu His 35 40 14939PRTHomo sapiens
149Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys
1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg
Arg Lys 20 25 30 Gly Ser Thr Phe Glu Glu Arg 35 15040PRTSus scrofa
150Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Ala Gln Lys
1 5 10 15 Tyr Gln Pro Pro Ser Thr Asn Lys Lys Thr Lys Ser Gln Arg
Arg Arg 20 25 30 Lys Gly Ser Thr Phe Glu Glu His 35 40
15140PRTCanis familiaris 151Arg Ser Val Arg Ala Gln Arg His Thr Asp
Met Pro Lys Ala Gln Lys 1 5 10 15 Tyr His Pro Pro Ser Thr Thr Lys
Arg Met Lys Ser Gln Arg Arg Arg 20 25 30 Lys Gly Ser Thr Phe Glu
Glu Cys 35 40 15240PRTOryctolagus cuniculus 152Arg Ser Val Arg Ala
Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Tyr Gln Pro
Pro Ser Thr Asn Lys Lys Met Lys Ser Gln Arg Arg Arg 20 25 30 Lys
Gly Ser Thr Phe Glu Glu His 35 40 15340PRTMacaca mulatta 153Arg Ser
Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys 1 5 10 15
Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Arg 20
25 30 Lys Gly Ser Thr Phe Glu Glu Arg 35 40 15440PRTMus musculus
154Arg Ser Ile Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln Lys
1 5 10 15 Ser Pro Ser Leu Ser Thr Asn Lys Lys Thr Lys Leu Gln Arg
Arg Arg 20 25 30 Lys Gly Ser Thr Phe Glu Glu His 35 40
15540PRTRattus norvegicus 155Arg Ser Ile Arg Ala Gln Arg His Thr
Asp Met Pro Lys Thr Gln Lys 1 5 10 15 Ser Gln Pro Leu Ser Thr His
Lys Lys Arg Lys Leu Gln Arg Arg Arg 20 25 30 Lys Gly Ser Thr Leu
Glu Glu His 35 40 156156PRTArtificial SequenceDescription of
Artificial Sequence Synthetic majority consensus polypeptide 156Ala
Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 1 5 10
15 Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala
20 25 30 Ser Arg Val Asn Arg Arg Ser Arg Gly Ile Val Glu Glu Cys
Cys Phe 35 40 45 Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys
Ala Thr Pro Ala 50 55 60 Lys Ser Glu Arg Asp Val Ser Thr Pro Pro
Thr Val Leu Pro Asp Asn 65 70 75 80 Phe Pro Arg Tyr Pro Val Gly Lys
Phe Phe Gln Tyr Asp Thr Trp Lys 85 90 95 Gln Ser Ala Gln Arg Leu
Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 100 105 110 Arg Arg Gly Arg
Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 115 120 125 Lys Arg
His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 130 135 140
Gly Gly Ala Ser Pro Glu Ala Ser Ser Asn Arg Lys 145 150 155
157156PRTHomo sapiens 157Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly
Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg
Gly Phe Tyr Phe Ser Arg Pro Ala 20 25 30 Ser Arg Val Ser Arg Arg
Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp
Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 50 55 60 Lys Ser
Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 65 70 75 80
Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 85
90 95 Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg
Ala 100 105 110 Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe
Arg Glu Ala 115 120 125 Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr
Gln Asp Pro Ala His 130 135 140 Gly Gly Ala Pro Pro Glu Met Ala Ser
Asn Arg Lys 145 150 155 158157PRTSus scrofa 158Ala Tyr Arg Pro Ser
Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe
Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 20 25 30 Ser
Arg Val Asn Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 35 40
45 Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala
50 55 60 Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro
Asp Asn 65 70 75 80 Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Arg Tyr
Asp Thr Trp Lys 85 90 95 Gln Ser Ala Gln Arg Leu Arg Arg Gly Leu
Pro Ala Leu Leu Arg Ala 100 105 110 Arg Arg Gly Arg Thr Leu Ala Lys
Glu Leu Glu Ala Val Arg Glu Ala 115 120 125 Lys Arg His Arg Pro Leu
Thr Ala Arg Pro Thr Arg Asp Pro Ala Ala 130 135 140 His Gly Gly Ala
Ser Pro Glu Ala Ser Gly His Arg Lys 145 150 155 159155PRTBos taurus
159Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr
1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg
Pro Ser 20 25 30 Ser Arg Ile Asn Arg Arg Ser Arg Gly Ile Val Glu
Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr
Tyr Cys Ala Thr Pro Ala 50 55 60 Lys Ser Glu Arg Asp Val Ser Ala
Ser Thr Thr Val Leu Pro Asp Asp 65 70 75 80 Val Thr Ala Tyr Pro Val
Gly Lys Phe Phe Gln Tyr Asp Ile Trp Lys 85 90 95 Gln Ser Thr Gln
Arg Leu Arg Arg Gly Leu Pro Ala Phe Leu Arg Ala 100 105 110 Arg Arg
Gly Arg Thr Leu Ala Lys Glu Leu Glu Ala Leu Arg Glu Ala 115 120 125
Lys Ser His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala Thr 130
135 140 His Gly Gly Ala Ser Ser Lys Ala Ser Ser Asp 145 150 155
160155PRTOvis aries 160Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly
Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly
Phe Tyr Phe Ser Arg Pro Ser 20 25 30 Ser Arg Ile Asn Arg Arg Ser
Arg Gly Ile Val Glu Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu
Ala Leu Leu Glu Thr Tyr Cys Ala Ala Pro Ala 50 55 60 Lys Ser Glu
Arg Asp Val Ser Ala Ser Thr Thr Val Leu Pro Asp Asp 65 70 75 80 Phe
Thr Ala Tyr Pro Val Gly Lys Phe Phe Gln Ser Asp Thr Trp Lys 85 90
95 Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Phe Leu Arg Ala
100 105 110 Arg Arg Gly Arg Thr Leu Ala Lys Glu Leu Glu Ala Leu Arg
Glu Ala 115 120 125 Lys Ser His Arg Pro Leu Ile Ala Leu Pro Thr Gln
Asp Pro Ala Thr 130 135 140 His Gly Gly Ala Ser Ser Glu Ala Ser Ser
Asp 145 150 155 161158PRTCanis familiaris 161Ala Tyr Arg Pro Ser
Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe
Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 20 25 30 Ser
Arg Val Thr Arg Arg Ser Ser Arg Gly Ile Val Glu Glu Cys Cys 35 40
45 Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro
50 55 60 Ala Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu
Pro Asp 65 70 75 80 Asn Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln
Tyr Asp Thr Trp 85 90 95 Lys Gln Ser Ala Gln Arg Leu Arg Arg Gly
Leu Pro Ala Leu Leu Arg 100 105 110 Ala Arg Arg Gly Arg Met Leu Ala
Lys Glu Leu Glu Ala Phe Arg Glu 115 120 125 Ala Lys Arg His Arg Pro
Leu Ile Ala Leu Pro Thr His Asp Pro Ala 130 135 140 Thr His Gly Gly
Ala Ser Pro Glu Ala Ser Gly Asn Gln Lys 145 150 155 162161PRTCanis
familiaris 162Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu
Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr
Phe Ser Asp Leu Ser 20 25 30 Arg Pro Ala Ser Arg Val Thr Arg Arg
Ser Ser Arg Gly Ile Val Glu 35 40 45 Glu Cys Cys Phe Arg Ser Cys
Asp Leu Ala Leu Leu Glu Thr Tyr Cys 50 55 60 Ala Thr Pro Ala Lys
Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val 65 70 75 80 Leu Pro Asp
Asn Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr 85 90 95 Asp
Thr Trp Lys Gln Ser Ala Gln Arg Leu Arg Arg Gly Leu Pro Ala 100 105
110 Leu Leu Arg Ala Arg Arg Gly Arg Met Leu Ala Lys Glu Leu Glu Ala
115 120 125 Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala Leu Pro
Thr His 130 135 140 Asp Pro Ala Thr His Gly Gly Ala Ser Pro Glu Ala
Ser Gly Asn Gln 145 150 155 160 Lys 163170PRTCanis familiaris
163Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr
1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Asp
Ala Ala 20 25 30 Leu Leu Pro Pro Val Gly Leu Pro Gly Arg Pro Ala
Ser Arg Val Thr 35 40 45 Arg Arg Ser Ser Arg Gly Ile Val Glu Glu
Cys Cys Phe Arg Ser Cys 50 55 60 Asp Leu Ala Leu Leu Glu Thr Tyr
Cys Ala Thr Pro Ala Lys Ser Glu 65 70 75 80 Arg Asp Val Ser Thr Pro
Pro Thr Val Leu Pro Asp Asn Phe Pro Arg 85 90 95 Tyr Pro Val Gly
Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Ala 100 105 110 Gln Arg
Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly 115 120 125
Arg Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His 130
135 140 Arg Pro Leu Ile Ala Leu Pro Thr His Asp Pro Ala Thr His Gly
Gly 145 150 155 160 Ala Ser Pro Glu Ala Ser Gly Asn Gln Lys 165 170
164164PRTGallus gallus 164Ala Tyr Gly Thr Ala Glu Thr Leu Cys Gly
Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg
Gly Phe Tyr Phe Ser Arg Pro Val 20 25 30 Gly Arg Asn Asn Arg Arg
Ile Asn Arg Gly Ile Val Glu Glu Cys Cys 35 40 45 Phe Arg Ser Cys
Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Lys Ser 50 55 60 Val Lys
Ser Glu Arg Asp Leu Ser Ala Thr Ser Leu Ala Gly Leu Pro 65 70 75 80
Ala Leu Asn Lys Glu Ser Phe Gln Lys Pro Ser His Ala Lys Tyr Ser 85
90 95 Lys Tyr Asn Val Trp Gln Lys Lys Ser Ser Gln Arg Leu Gln Arg
Glu 100 105 110 Val Pro Gly Ile Leu Arg Ala Arg Arg Tyr Arg Trp Gln
Ala Glu Gly 115 120 125 Leu Gln Ala Ala Glu Glu Ala Arg Ala Met His
Arg Pro Leu Ile Ser 130 135 140 Leu Pro Ser Gln Arg Pro Pro Ala Pro
Arg Ala Ser Pro Glu Ala Thr 145 150 155 160 Gly Pro Gln Glu
165156PRTRattus norvegicus 165Ala Tyr Arg Pro Ser Glu Thr Leu Cys
Gly Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Ser
Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ser 20 25 30 Ser Arg Ala Asn
Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 35 40 45 Arg Ser
Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 50 55 60
Lys Ser Glu Arg Asp Val Ser Thr Ser Gln Ala Val Leu Pro Asp Asp 65
70 75 80 Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Lys Phe Asp Thr
Trp Arg 85 90 95 Gln Ser Ala Gly Arg Leu Arg Arg Gly Leu Pro Ala
Leu Leu Arg Ala 100 105 110 Arg Arg Gly Arg Met Leu Ala Lys Glu Leu
Glu Ala Phe Arg Glu Ala 115 120 125 Lys Arg His Arg Pro Leu Ile Val
Leu Pro Pro Lys Asp Pro Ala His 130 135 140 Gly Gly Ala Ser Ser Glu
Met Ser Ser Asn His Gln 145 150 155 166156PRTMus musculus 166Ala
Tyr Gly Pro Gly Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 1 5 10
15 Leu Gln Phe Val Cys Ser Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ser
20 25 30 Ser Arg Ala Asn Arg Arg Ser Arg Gly Ile Val Glu Glu Cys
Cys Phe 35 40 45 Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys
Ala Thr Pro Ala 50 55 60 Lys Ser Glu Arg Asp Val Ser Thr Ser Gln
Ala Val Leu Pro Asp Asp 65 70 75 80 Phe Pro Arg Tyr Pro Val Gly Lys
Phe Phe Gln Tyr Asp Thr Trp Arg 85 90 95 Gln Ser Ala Gly Arg Leu
Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 100 105 110 Arg Arg Gly Arg
Met Leu Ala Lys Glu Leu Lys Glu Phe Arg Glu Ala 115 120 125 Lys Arg
His Arg Pro Leu Ile Val Leu Pro Pro Lys Asp Pro Ala His 130 135 140
Gly Gly Ala Ser Ser Glu Met Ser Ser Asn His Gln 145 150 155
167160PRTPan troglodytes 167Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly
Gly Glu Leu Val Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg
Gly Phe Tyr Phe Ser Lys Ala Ser 20 25 30 Thr Pro Ala Ala Phe Pro
Ile Thr Arg Pro Leu Arg Arg Val Gly Gln 35 40 45 Arg Cys Cys Arg
Gly Gly Cys Pro Pro Ala Asp Leu Arg Asp Ala Ser 50 55 60 Ala Phe
Pro Arg Arg Glu Ser Arg His Leu Leu Thr Ser Pro Phe Pro 65 70 75 80
Ser Gln Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr 85
90 95 Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro
Ala 100 105 110 Leu Leu Arg Ala Arg Arg Gly His Met Leu Ala Lys Glu
Leu Glu Ala 115 120 125 Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile
Ala Leu Pro Thr Gln 130 135 140 Asp Pro Ala His Gly Gly Ala Pro Pro
Glu Met Ala Ser Asn Arg Lys 145 150 155 160 168167PRTDanio rerio
168Glu Val Ala Ser Ala Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Ala
1 5 10 15 Leu Gln Phe Val Cys Glu Asp Arg Gly Phe Tyr Phe Ser Arg
Pro Thr 20 25 30 Ser Arg Ser Asn Ser Arg Arg Ser Gln Asn Arg Gly
Ile Val Glu Glu 35 40 45 Cys Cys Phe Ser Ser Cys Asn Leu Ala Leu
Leu Glu Gln Tyr Cys Ala 50 55 60 Lys Pro Ala Lys Ser Glu Arg Asp
Val Ser Ala Thr Ser Leu Gln Val 65 70 75 80 Ile Pro Val Met Pro Ala
Leu Lys Gln Glu Val Pro Arg Lys His Val 85 90 95 Thr Val Lys Tyr
Ser Lys Tyr Asp Val Trp Gln Arg Lys Ala Ala Gln 100 105 110 Arg Leu
Arg Arg Gly Ile Pro Ala Ile Leu Arg Ala Lys Lys Phe Arg 115 120 125
Arg Gln Ala Glu Arg Ile Lys Ala Gln Glu Gln Leu Leu His His Arg 130
135 140 Pro Leu Ile Thr Leu Pro Ser Lys Leu Pro Pro Ile Leu Leu Pro
Thr 145 150 155 160 Glu Asn Tyr Val Ser His Lys 165 169161PRTDanio
rerio 169Asn Val Thr Ala Gly Glu Thr Leu Cys Gly Gly Glu Leu Val
Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Glu Asp Gly Phe Tyr Ile
Ser Arg Pro Asn 20 25 30 Arg Ser Asn Ser Arg Arg Pro Gln Arg Gly
Ile Val Glu Glu Cys Cys 35 40 45 Phe Arg Ser Cys Glu Leu His Leu
Leu Gln Gln Tyr Cys Ala Lys Pro 50 55 60 Val Lys Ser Glu Arg Asp
Val Ser Ser Thr Ser Leu Gln Val Phe Pro 65 70 75 80 Val Ser Gln Ala
Leu His Lys Asp Thr Ile Asn Val Lys Tyr Ser Lys 85 90 95 Tyr Glu
Val Trp Gln Gln Lys Ala Ala Gln Arg Leu Arg Arg Gly Val 100 105 110
Pro Ser Ile Leu Leu Ala Arg Lys Phe Arg Arg Gln Met Glu Lys Ile 115
120 125 Gln Asp Glu Glu Gln Thr Ser Phe His Arg Pro Leu Met Thr Leu
Pro 130 135 140 Asn Arg Gln Pro Ala Ile Val Pro His Val Gln Ile Ser
Thr Ser Arg 145 150 155 160 Lys 17089PRTHomo sapiens 170Arg Asp Val
Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg 1 5 10 15 Tyr
Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Ala 20 25
30 Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly
35 40 45 Arg Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys
Arg His 50 55 60 Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala
His Gly Gly Ala 65 70 75 80 Ser Pro Glu Ala Ser Ser Asn Arg Lys 85
17190PRTSus scrofa 171Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro
Asp Asn Phe Pro Arg 1 5 10 15 Tyr Pro Val Gly Lys Phe Phe Arg Tyr
Asp Thr Trp Lys Gln Ser Ala 20 25 30 Gln Arg Leu Arg Arg Gly Leu
Pro Ala Leu Leu Arg Ala Arg Arg Gly 35 40 45 Arg Thr Leu Ala Lys
Glu Leu Glu Ala Val Arg Glu Ala Lys Arg His 50 55 60 Arg Pro Leu
Thr Ala Arg Pro Thr Arg Asp Pro Ala Ala His Gly Gly 65 70 75 80 Ala
Ser Pro Glu Ala Ser Gly His Arg Lys 85 90 17288PRTBos taurus 172Arg
Asp Val Ser Ala Ser Thr Thr Val Leu Pro Asp Asp Val Thr Ala 1 5 10
15 Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Ile Trp Lys Gln Ser Thr
20 25 30 Gln Arg Leu Arg Arg Gly Leu Pro Ala Phe Leu Arg Ala Arg
Arg Gly 35 40 45 Arg Thr Leu Ala Lys Glu Leu Glu Ala Leu Arg Glu
Ala Lys Ser His 50 55 60 Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp
Pro Ala Thr His Gly Gly 65 70 75 80 Ala Ser Ser Lys Ala Ser Ser Asp
85 17388PRTOvis aries 173Arg Asp Val Ser Ala Ser Thr Thr Val Leu
Pro Asp Asp Phe Thr Ala 1 5 10 15 Tyr Pro Val Gly Lys Phe Phe Gln
Ser Asp Thr Trp Lys Gln Ser Thr 20 25 30 Gln Arg Leu Arg Arg Gly
Leu Pro Ala Phe Leu Arg Ala Arg Arg Gly 35 40 45 Arg Thr Leu Ala
Lys Glu Leu Glu Ala Leu Arg Glu Ala Lys Ser His 50 55 60 Arg Pro
Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala Thr His Gly Gly 65 70 75 80
Ala Ser Ser Glu Ala Ser Ser Asp 85 17490PRTCanis familiaris 174Arg
Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg 1 5 10
15 Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Ala
20 25 30 Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg
Arg Gly 35 40 45 Arg Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu
Ala Lys Arg His 50 55 60 Arg Pro Leu Ile Ala Leu Pro Thr His Asp
Pro Ala Thr His Gly Gly 65 70 75 80 Ala Ser Pro Glu Ala Ser Gly Asn
Gln Lys 85 90 17596PRTGallus gallus 175Arg Asp Leu Ser Ala Thr Ser
Leu Ala Gly Leu Pro Ala Leu Asn Lys 1 5 10 15 Glu Ser Phe Gln Lys
Pro Ser His Ala Lys Tyr Ser Lys Tyr Asn Val 20 25 30 Trp Gln Lys
Lys Ser Ser Gln Arg Leu Gln Arg Glu Val Pro Gly Ile 35 40 45 Leu
Arg Ala Arg Arg Tyr Arg Trp Gln Ala Glu Gly Leu Gln Ala Ala 50 55
60 Glu Glu Ala Arg Ala Met His Arg Pro Leu Ile Ser Leu Pro Ser Gln
65 70 75 80 Arg Pro Pro Ala Pro Arg Ala Ser Pro Glu Ala Thr Gly Pro
Gln Glu 85 90 95 17689PRTRattus norvegicus 176Arg Asp Val Ser Thr
Ser Gln Ala Val Leu Pro Asp Asp Phe Pro Arg 1 5 10 15 Tyr Pro Val
Gly Lys Phe Phe Lys Phe Asp Thr Trp Arg Gln Ser Ala 20 25 30 Gly
Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly 35 40
45 Arg Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His
50 55 60 Arg Pro Leu Ile Val Leu Pro Pro Lys Asp Pro Ala His Gly
Gly Ala 65 70 75 80 Ser Ser Glu Met Ser Ser Asn His Gln 85
17789PRTMus musculus 177Arg Asp Val Ser Thr Ser Gln Ala Val Leu Pro
Asp Asp Phe Pro Arg 1 5 10 15 Tyr Pro Val Gly Lys Phe Phe Gln Tyr
Asp Thr Trp Arg Gln Ser Ala 20 25 30 Gly Arg Leu Arg Arg Gly Leu
Pro Ala Leu Leu Arg Ala Arg Arg Gly 35 40 45 Arg Met Leu Ala Lys
Glu Leu Lys Glu Phe Arg Glu Ala Lys Arg His 50 55 60 Arg Pro Leu
Ile Val Leu Pro Pro Lys Asp Pro Ala His Gly Gly Ala 65 70 75 80 Ser
Ser Glu Met Ser Ser Asn His Gln 85 17889PRTPan troglodytes 178Arg
His Leu Leu Thr Ser Pro Phe Pro Ser Gln Asp Asn Phe Pro Arg 1 5 10
15 Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr
20 25 30 Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg
Arg Gly 35 40 45 His Met Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu
Ala Lys Arg His 50 55 60 Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp
Pro Ala His Gly Gly Ala 65 70 75 80 Pro Pro Glu Met Ala Ser Asn Arg
Lys 85 17997PRTDanio rerio 179Arg Asp Val Ser Ala Thr Ser Leu Gln
Val Ile Pro Val Met Pro Ala 1 5 10 15 Leu Lys Gln Glu Val Pro Arg
Lys His Val Thr Val Lys Tyr Ser Lys 20 25 30 Tyr Asp Val Trp Gln
Arg Lys Ala Ala Gln Arg Leu Arg Arg Gly Ile 35 40 45 Pro Ala Ile
Leu Arg Ala Lys Lys Phe Arg Arg Gln Ala Glu Arg Ile 50 55 60 Lys
Ala Gln Glu Gln Leu Leu His His Arg Pro Leu Ile Thr Leu Pro 65 70
75 80 Ser Lys Leu Pro Pro Ile Leu Leu Pro Thr Glu Asn Tyr Val Ser
His 85 90 95 Lys 18093PRTDanio rerio 180Arg Asp Val Ser Ser Thr Ser
Leu Gln Val Phe Pro Val Ser Gln Ala 1 5 10 15 Leu His Lys Asp Thr
Ile Asn Val Lys Tyr Ser Lys Tyr Glu Val Trp 20 25 30 Gln Gln Lys
Ala Ala Gln Arg Leu Arg Arg Gly Val Pro Ser Ile Leu 35 40 45 Leu
Ala Arg Lys Phe Arg Arg Gln Met Glu Lys Ile Gln Asp Glu Glu 50 55
60 Gln Thr Ser Phe His Arg Pro Leu Met Thr Leu Pro Asn Arg Gln Pro
65 70 75 80 Ala Ile Val Pro His Val Gln Ile Ser Thr Ser Arg Lys 85
90 181106PRTHomo sapiens 181Gly Thr Leu Cys Gly Ala Glu Leu Val Asp
Ala Leu Gln Phe Val Cys 1 5 10 15 Gly Asp Arg Gly Phe Tyr Phe Asn
Lys Pro Thr Gly Tyr Gly Ser Ser 20 25 30 Ser Arg Ala Ala Pro Gln
Thr Gly Ile Val Asp Glu Cys Cys Phe Arg 35 40 45 Ser Cys Asp Leu
Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro 50 55 60 Ala Lys
Ser Ala Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr 65 70 75 80
Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg 85
90 95 Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 100 105 182156PRTHomo
sapiens 182Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val
Asp Thr 1 5 10 15 Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe
Ser Arg Pro Ala 20 25 30 Ser Arg Val Ser Arg Arg Ser Arg Gly Ile
Val Glu Glu Cys Cys Phe 35 40 45 Arg Ser Cys Asp Leu Ala Leu Leu
Glu Thr Tyr Cys Ala Thr Pro Ala 50 55 60 Lys Ser Glu Arg Asp Val
Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 65 70 75 80 Phe Pro Arg Tyr
Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 85 90 95 Gln Ser
Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 100 105 110
Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 115
120 125 Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala
His 130 135 140 Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 145
150 155 1836PRTArtificial SequenceDescription of Artificial
Sequence Synthetic 6xHis tag 183His His His His His His 1 5
18435PRTArtificial SequenceDescription of Artificial Sequence
Synthetic majority consensus peptide 184Arg Ser Val Arg Ala Gln Arg
His Thr Asp Met Pro Lys Ala Gln Lys 1 5 10 15 Glu Val His Leu Lys
Asn Thr Ser Arg Gly Ser Thr Gly Asn Lys Asn 20 25 30 Tyr Arg Met
35
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