U.S. patent application number 14/082000 was filed with the patent office on 2014-06-26 for adipate (ester or thioester) synthesis. This patent application is currently assigned to DSM IP ASSETS B.V.. The applicant listed for this patent is DSM IP ASSETS B.V.. Invention is credited to STEFAAN MARIE ANDRE DE WILDEMAN, AXEL CHRISTOPH TREFZER, MARCO ALEXANDER VAN DEN BERG, LIANG WU.
Application Number | 20140178949 14/082000 |
Document ID | / |
Family ID | 39771877 |
Filed Date | 2014-06-26 |
United States Patent Application | 20140178949 |
Kind Code | A1 |
WU; LIANG ; et al. | June 26, 2014 |
The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.
Inventors: | WU; LIANG; (DELFT, NL) ; TREFZER; AXEL CHRISTOPH; (LEIDSCHENDAM, NL) ; DE WILDEMAN; STEFAAN MARIE ANDRE; (MAASMECHELEN, BE) ; VAN DEN BERG; MARCO ALEXANDER; (POELDIJK, NL) | ||||||||||
Applicant: |
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Assignee: | DSM IP ASSETS B.V. HEERLEN NL |
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Family ID: | 39771877 | ||||||||||
Appl. No.: | 14/082000 | ||||||||||
Filed: | November 15, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13841142 | Mar 15, 2013 | |||
14082000 | ||||
13572346 | Aug 10, 2012 | |||
13841142 | ||||
12921547 | Dec 13, 2010 | |||
PCT/NL2009/050115 | Mar 11, 2009 | |||
13572346 | ||||
Current U.S. Class: | 435/130 ; 435/142; 435/252.3; 435/252.31; 435/252.32; 435/252.33; 435/252.34; 435/254.21; 435/254.23; 435/254.3; 435/254.5 |
Current CPC Class: | C12P 7/44 20130101; C12N 15/70 20130101; C12P 7/62 20130101; C12P 17/10 20130101 |
Class at Publication: | 435/130 ; 435/254.3; 435/142; 435/252.31; 435/252.32; 435/252.33; 435/254.21; 435/252.34; 435/252.3; 435/254.5; 435/254.23 |
International Class: | C12P 7/44 20060101 C12P007/44; C12N 15/70 20060101 C12N015/70 |
Date | Code | Application Number |
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Mar 11, 2008 | EP | 08152595.8 |
Sequence CWU 1
1
1481419PRTPenicillium chrysogenum 1Met Ser Asn Ala Gln Gln Arg Leu
Ser Gln Val Ser Ser His Phe Gly 1 5 10 15 Pro Gly Gly Lys Lys Gly
Ala Ala Ala Ile Thr Glu Lys His Pro Asp 20 25 30 Asp Ile Val Val
Thr Cys Ala Leu Arg Thr Ala Leu Thr Lys Gly Gly 35 40 45 Lys Gly
Gly Phe Lys Asp Thr Ala Gly Ala Asp Leu Leu Ala Gly Val 50 55 60
Phe Lys Ala Val Leu Asn Lys Ser Gly Val Asp Pro Ser Ser Val Gln 65
70 75 80 Asp Ile Ala Val Gly Ser Val Leu Ala Pro Gly Gly Gly Ala
Thr Glu 85 90 95 Phe Arg Ala Ala Ala Leu Val Ala Gly Phe Pro Glu
Ser Thr Ala Val 100 105 110 Lys Ser Leu Asn Arg Gln Cys Ser Ser Gly
Leu Gln Ala Ile Ala Asp 115 120 125 Ile Ala Asn Ala Ile Gln Ser Gly
Met Ile Asp Val Gly Ile Gly Ala 130 135 140 Gly Val Glu Ser Met Ser
Ser Gln Tyr Gly Pro Gly Ala Val Thr Glu 145 150 155 160 Phe Ser Asp
Leu Leu Glu Ser His Pro Glu Ser Ala Asn Cys Lys Val 165 170 175 Pro
Met Gly Val Leu Ser Glu Asn Met Ala Lys Asp Arg Gly Val Thr 180 185
190 Arg Ala Ser Gln Asp Ser Phe Ala Ala Gln Ser Tyr Gln Lys Ala Val
195 200 205 Ala Ala Gln Lys Ala Gly Leu Phe Asn Glu Glu Ile Ala Pro
Leu Asp 210 215 220 Val Lys Trp Thr Asp Pro Lys Thr Gly Glu Glu Lys
Thr Ile Thr Val 225 230 235 240 Lys Ala Asp Asp Gly Val Arg Gln Gly
Ile Thr Ala Glu Ser Leu Gly 245 250 255 Lys Ile Lys Pro Ala Phe Ala
Lys Asp Gly Ser Ile His Ala Gly Asn 260 265 270 Ala Ser Gln Ile Ser
Asp Gly Ala Ala Ala Val Leu Leu Met Lys Arg 275 280 285 Ser Thr Ala
Glu Arg Leu Gly Gln Lys Ile Leu Gly Lys Tyr Val Thr 290 295 300 Ala
Ser Val Val Gly Val Lys Pro Leu Leu Met Gly Val Gly Pro Trp 305 310
315 320 Lys Ala Ile Pro Val Ala Leu Glu Lys Ala Gly Ile Thr Lys Asp
Asp 325 330 335 Val Asp Ile Tyr Glu Ile Asn Glu Ala Phe Ala Ser Gln
Cys Val Trp 340 345 350 Cys Val Asn Glu Leu Gly Ile Pro Ala Glu Lys
Val Asn Pro Lys Gly 355 360 365 Gly Ala Ile Ala Phe Gly His Pro Leu
Gly Cys Thr Gly Ala Arg Gln 370 375 380 Val Ser Thr Leu Phe Thr Glu
Leu Lys Arg Thr Asn Lys Lys Ile Gly 385 390 395 400 Val Thr Ser Met
Cys Val Gly Thr Gly Met Gly Met Ala Ala Val Trp 405 410 415 Val Ser
Glu 2418PRTPenicillium chrysogenum 2Met Ser Ser Pro Gln Gln Arg Leu
Asn Ser Val Ala Asn Gln Leu Ala 1 5 10 15 Pro Gly Ser Ala Arg Gln
Lys Ile Leu Ala Lys Asn Pro Asp Asp Val 20 25 30 Val Ile Thr Tyr
Leu Ala Arg Thr Pro Leu Thr Lys Ala Arg Lys Gly 35 40 45 Gly Leu
Lys Asp Thr Thr Val Asp Asp Leu Leu Ile Ser Leu Leu Thr 50 55 60
Thr Val Arg Glu Lys Ser Asn Leu Asp Pro Asn Leu Val Glu Asp Val 65
70 75 80 Cys Val Gly Asn Val Leu Cys Pro Gly Ser Ala Tyr Val Ala
Arg Ser 85 90 95 Ala Val Leu Ala Ala Gly Tyr Pro Val Thr Ala Ala
Ala Ser Ile Ala 100 105 110 Asn Arg Phe Cys Ser Ser Gly Leu Leu Ala
Val Gln Asn Ile Ala Asn 115 120 125 Gln Ile Ile Ala Gly Ser Ile Asp
Val Gly Val Ala Val Gly Ala Glu 130 135 140 Ser Met Ser Lys Asn Ala
Asp Gly Gly Ala Pro Glu Met Ser Glu Arg 145 150 155 160 Ile Thr Lys
His Pro Ile Ala Ser Gln Asn Ser Gln Pro Met Gly Gln 165 170 175 Thr
Ser Glu Asn Val Ala Asn Gln Phe Asn Ile Ser Arg Glu Gln His 180 185
190 Asp Arg Phe Ala Ala Asn Ser Phe Gln Lys Ala Glu Arg Ala Gln Lys
195 200 205 Ala Gly Trp Leu Glu Asp Glu Ile Val Pro Val Arg Thr Gln
Ile Lys 210 215 220 Asp Pro Lys Thr Gly Glu Val Lys Asp Ile Val Val
Val Arg Asp Asp 225 230 235 240 Gly Ile Arg Tyr Gly Thr Thr Pro Glu
Ser Leu Gly Lys Val Arg Ala 245 250 255 Ala Phe Pro Gln Trp Ala Pro
Ser Ala Thr Thr Gly Gly Asn Ala Ser 260 265 270 Gln Ile Thr Asp Gly
Ala Ala Ala Leu Val Leu Met Lys Arg Ser Arg 275 280 285 Ala Gln Gln
Leu Gly Gln Pro Ile Val Ala Lys Phe Cys Gly Ala Thr 290 295 300 Val
Ser Gly Leu Glu Pro Arg Ile Met Gly Ile Gly Pro Ser Leu Ala 305 310
315 320 Ile Pro Lys Ile Leu Ser Lys Phe Asn Leu Ser Lys Asp Asp Ile
Asp 325 330 335 Ile Phe Glu Ile Asn Glu Ala Phe Ser Ser Met Gly Val
Tyr Cys Val 340 345 350 Asn Lys Leu Gly Leu Asp Glu Ser Lys Val Asn
Pro Arg Gly Gly Ala 355 360 365 Ile Ala Phe Gly His Pro Leu Gly Ala
Thr Gly Ala Arg Gln Val Val 370 375 380 Thr Ala Leu Ser Glu Leu Arg
Arg Gln Asp Lys Arg Val Ala Val Thr 385 390 395 400 Ser Met Cys Val
Gly Thr Gly Met Gly Met Ala Gly Ile Phe Val Ser 405 410 415 Glu His
3418PRTPenicillium chrysogenum 3Met Ala Ala Asp Arg Leu Ser Ser Leu
Leu Ser His Leu Lys Pro Gly 1 5 10 15 Ala Thr Asn Gly Leu Ala Ala
Ile Thr Gln Lys Asn Pro Asp Asp Val 20 25 30 Val Ile Thr Leu Ala
Ile Arg Thr Pro Leu Thr Lys Ala Arg Lys Gly 35 40 45 Gly Phe Lys
Asp Thr Glu Leu Asp Tyr Met Ile Tyr Ala Leu Leu Lys 50 55 60 Glu
Thr Leu Ala Lys Ser Gln Ile Asp Pro Ala Leu Ile Glu Asp Val 65 70
75 80 Cys Leu Gly Asn Val Asn Glu Val Lys Ala Ala Tyr Met Val Arg
Ala 85 90 95 Ala Ala Leu Ala Ala Gly Ile Pro His Thr Ala Gly Ala
Ser Ser Val 100 105 110 Asn Arg Phe Cys Ser Ser Gly Leu Lys Ala Val
Gln Asp Ile Ala Asn 115 120 125 Gln Ile Gln Leu Gly Ala Ile Asp Val
Gly Val Ala Leu Gly Ala Glu 130 135 140 Leu Met Ser Ala Ser Gly Asp
Arg Leu Asp Arg Pro Phe Asn Glu Glu 145 150 155 160 Val Leu Arg Asn
Gln Glu Ala Ala Asp Cys Met Gln Pro Met Gly Gln 165 170 175 Thr Ser
Glu Asn Val Gly Lys Asp Phe Asp Ile Pro Arg Glu Gln Gln 180 185 190
Asp Arg Tyr Ala Ala Glu Ser Phe Arg Arg Ala Glu Ala Ala Gln Asn 195
200 205 Asn Gly Trp Leu Asp Asp Glu Ile Ala Pro Ile Ala Val Lys Val
Lys 210 215 220 Asp Pro Lys Thr Gly Glu Val Lys Glu Val Thr Leu Ser
Arg Asp Asp 225 230 235 240 Gly Ile Arg Pro Gly Thr Thr Phe Glu Ser
Leu Ser Lys Ile Arg Pro 245 250 255 Ala Phe Pro Gln Phe Gly Asp Lys
Ser Thr Gly Gly Asn Ser Ser Gln 260 265 270 Val Thr Asp Gly Ala Ala
Ser Val Leu Leu Met Arg Arg Ser Lys Ala 275 280 285 Ile Glu Leu Asn
Gln Pro Ile Leu Ala Lys Phe Cys Gly Ala Thr Val 290 295 300 Ala Gly
Val Pro Pro Arg Val Met Gly Ile Gly Pro Thr Ala Ala Ile 305 310 315
320 Pro Lys Leu Leu Ser Lys Phe Gln Leu Asp Lys Asn Asp Ile Asp Ile
325 330 335 Tyr Glu Ile Asn Glu Ala Phe Ala Ser Met Ala Val Tyr Cys
Val Lys 340 345 350 Asn Leu Gly Leu Asp His Ala Lys Val Asn Pro Arg
Gly Gly Ala Ile 355 360 365 Ala Leu Gly His Pro Leu Gly Ala Thr Gly
Ala Arg Gln Ile Ala Thr 370 375 380 Ile Leu Ser Glu Ala Arg Arg Thr
Lys Ser Lys Ile Leu Val Thr Ser 385 390 395 400 Met Cys Ile Gly Thr
Gly Gln Gly Met Ala Gly Leu Phe Val Asn Glu 405 410 415 Gln Leu
4413PRTPenicillium chrysogenum 4Met Ala Ser Pro Ile Pro Arg Gly Leu
Arg Gln Val Leu Gln Lys Ser 1 5 10 15 Ser Asn Asp Ile Val Ile Leu
Ser Ser Leu Arg Thr Pro Val Thr Arg 20 25 30 Ala Lys Lys Gly Gly
Phe Lys Asp Ala Tyr Pro Glu Glu Leu Leu Ala 35 40 45 Ser Val Leu
Gln Ala Thr Leu Lys Ala Asn Pro Asn Leu Asp Pro Ala 50 55 60 Gln
Ile Asp Asp Val Leu Ile Gly Ser Val Leu Gln Glu Leu Gly Gly 65 70
75 80 Ala Lys Ala Gly Arg Met Gly Gln Ile His Ala Gly Phe Pro His
Ser 85 90 95 Val Pro Phe Asn Thr Ile Asn Arg Gln Cys Ser Ser Gly
Leu Ala Ala 100 105 110 Ile Thr Thr Ile Ala Asn Gly Ile Arg Ala Gly
Ala Ile Asn Val Gly 115 120 125 Val Gly Gly Gly Met Glu Ser Met Thr
Arg Asn Tyr Gly Ser Arg Ala 130 135 140 Ile Pro Thr Val Leu Trp Pro
Glu Leu Lys Glu Ser Tyr Ser Gln Asp 145 150 155 160 Ala Arg Asp Cys
Ile Met Pro Met Gly Ile Thr Ser Glu Asn Val Ala 165 170 175 Ser Arg
Tyr Gly Val Ser Arg Ala Asp Gln Asp Ala Phe Ala Val Glu 180 185 190
Ser His Ala Lys Ala Ser Ala Ala Gln Lys Ala Gly Arg Phe Asp Ser 195
200 205 Glu Ile Val Ser Val Thr Thr Lys Thr Leu Asp Pro Glu Asn Pro
Asp 210 215 220 Ala Pro Ala Arg Asp Val Thr Val Ser Gln Asp Asp Gly
Ile Arg His 225 230 235 240 Gly Leu Ser Ile Glu Lys Val Gly Ala Leu
Lys Pro Ala Phe Ser Pro 245 250 255 Thr Gly Ala Ser Thr Ala Gly Asn
Ser Ser Gln Val Ser Asp Gly Ala 260 265 270 Ala Ala Thr Leu Leu Met
Arg Arg Ser Thr Ala Glu Glu Leu Gly Leu 275 280 285 Ser Gly Ser Ile
Lys Ala Arg Trp Val Ala Ser Ala Val Ala Gly Cys 290 295 300 Ala Pro
Asp Glu Met Gly Val Gly Pro Ala Val Ala Ile Pro Lys Leu 305 310 315
320 Leu Gln Thr Val Gly Val Glu Val Pro Glu Val Gly Val Trp Glu Ile
325 330 335 Asn Glu Ala Phe Ala Ser Gln Ala Leu Tyr Ser Val Arg Lys
Leu Gly 340 345 350 Ile Asp Gln Ala Lys Val Asn Pro Asn Gly Gly Ala
Ile Ala Ile Gly 355 360 365 His Pro Leu Gly Ala Thr Gly Ala Arg Gln
Leu Ala Thr Leu Leu Pro 370 375 380 Glu Leu Glu Arg Ser Gly Gln Glu
Ile Gly Val Ile Ser Met Cys Ile 385 390 395 400 Gly Thr Gly Met Gly
Met Ala Gly Met Phe Val Arg Glu 405 410 5401PRTAcinetobacter sp.
5Met Leu Asn Ala Tyr Ile Tyr Asp Gly Leu Arg Thr Pro Phe Gly Arg 1
5 10 15 His Ala Gly Glu Leu Ala Ser Ile Arg Pro Asp Asp Leu Ala Gly
Leu 20 25 30 Val Ile Gln Arg Leu Ile Glu Lys Thr Gly Val Ala Gly
Ala Asp Ile 35 40 45 Glu Asp Val Ile Phe Gly Asp Thr Asn Gln Ala
Gly Glu Asp Ser Arg 50 55 60 Asn Ile Ala Arg His Ala Ala Leu Leu
Ala Gly Leu Pro Val Thr Val 65 70 75 80 Pro Gly Gln Thr Val Asn Arg
Leu Cys Ala Ser Gly Leu Ala Ala Ile 85 90 95 Ile Asp Ser Ala Arg
Ala Ile Thr Cys Gly Glu Gly Asp Leu Tyr Ile 100 105 110 Ala Gly Gly
Val Glu Ser Met Ser Arg Ala Pro Phe Val Met Gly Lys 115 120 125 Ala
Glu Ser Ala Tyr Ser Arg Asp Ala Lys Ile Tyr Asp Thr Thr Ile 130 135
140 Gly Thr Arg Phe Pro Asn Lys Lys Ile Val Ala Gln Tyr Gly Gly His
145 150 155 160 Ser Met Pro Glu Thr Gly Asp Asn Val Ala Val Glu Tyr
Gly Ile Ser 165 170 175 Arg Glu Gln Ala Asp Leu Phe Ala Ala Gln Ser
Gln Ala Lys Tyr Gln 180 185 190 Lys Ala Leu Glu Glu Gly Phe Phe Ala
Gly Glu Ile Thr Ala Val Glu 195 200 205 Val Ser Gln Gly Lys Lys Leu
Pro Pro Lys Gln Val Thr Glu Asp Glu 210 215 220 His Pro Arg Pro Ser
Ser Thr Leu Glu Ala Leu Ser Lys Leu Lys Pro 225 230 235 240 Leu Phe
Glu Gly Gly Val Val Thr Ala Gly Asn Ala Ser Gly Ile Asn 245 250 255
Asp Gly Ala Ala Ala Leu Leu Ile Gly Ser Glu Val Ala Gly Gln Lys 260
265 270 Tyr Gly Leu Thr Pro Met Ala Lys Ile Leu Ser Ala Ala Ala Ala
Gly 275 280 285 Val Glu Pro Arg Ile Met Gly Ala Gly Pro Ile Glu Ala
Ile Lys Lys 290 295 300 Ala Val Ala Arg Ala Gly Leu Thr Leu Asp Asp
Leu Asp Ile Ile Glu 305 310 315 320 Ile Asn Glu Ala Phe Ala Ser Gln
Val Leu Ser Cys Leu Lys Gly Leu 325 330 335 Gly Ile Asp Phe Asn Asp
Pro Arg Val Asn Pro Asn Gly Gly Ala Ile 340 345 350 Ala Val Gly His
Pro Leu Gly Ala Ser Gly Ala Arg Leu Ala Leu Thr 355 360 365 Val Ala
Arg Glu Leu Gln Arg Arg Asn Lys Lys Tyr Ala Val Val Ser 370 375 380
Leu Cys Ile Gly Val Gly Gln Gly Leu Ala Met Val Ile Glu Asn Val 385
390 395 400 Ser 6393PRTClostridium kluyveri 6Met Arg Glu Val Val
Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser 1 5 10 15 Phe Gly Gly
Thr Leu Lys Asp Val Ser Ala Val Asp Leu Gly Ala Ile 20 25 30 Val
Ile Lys Glu Ala Val Lys Arg Ala Gly Ile Lys Pro Glu Gln Val 35 40
45 Asp Glu Val Ile Phe Gly Asn Val Ile Gln Ala Gly Val Gly Gln Ser
50 55 60 Leu Ala Arg Gln Ser Ala Val Tyr Ala Gly Leu Pro Val Glu
Val Pro 65 70 75 80 Ala Phe Thr Val Asn Lys Leu Cys Gly Ser Gly Leu
Arg Thr Val Ser 85 90 95 Leu Ala Ala Ser Leu Ile Ser Asn Gly Asp
Ala Asp Thr Ile Val Val 100 105 110 Gly Gly Ser Glu Asn Met Ser Ala
Ser Pro Tyr Leu Ile Pro Lys Ala 115 120 125 Arg Phe Gly Tyr Arg Met
Gly Glu Ala Lys Ile Tyr Asp Ala Met Leu 130 135 140 His Asp Gly Leu
Ile Asp Ser Phe Asn Asn Tyr His Met Gly Ile Thr 145 150 155 160 Ala
Glu Asn Ile Ala Glu Lys Trp Gly Ile Thr Arg Glu Asp Gln Asp 165 170
175 Lys Phe Ala Leu Ala Ser Gln Gln Lys Ala Glu Ala Ala Ile Lys Ala
180 185 190 Gly Lys Phe Lys Asp Glu Ile Val Pro Val Thr Val Lys Met
Lys Lys 195 200 205 Lys Glu Val Val Phe Asp Thr
Asp Glu Asp Pro Arg Phe Gly Thr Thr 210 215 220 Ile Glu Thr Leu Ala
Lys Leu Lys Pro Ala Phe Lys Arg Asp Gly Thr 225 230 235 240 Gly Thr
Val Thr Ala Gly Asn Ser Ser Gly Ile Asn Asp Ser Ser Ala 245 250 255
Ala Leu Ile Leu Met Ser Ala Asp Lys Ala Lys Glu Leu Gly Val Lys 260
265 270 Pro Met Ala Lys Tyr Val Asp Phe Ala Ser Ala Gly Leu Asp Pro
Ala 275 280 285 Ile Met Gly Tyr Gly Pro Tyr Tyr Ala Thr Lys Lys Val
Leu Ala Lys 290 295 300 Thr Asn Leu Thr Ile Lys Asp Phe Asp Leu Ile
Glu Ala Asn Glu Ala 305 310 315 320 Phe Ala Ala Gln Ser Ile Ala Val
Ala Arg Asp Leu Glu Phe Asp Met 325 330 335 Ser Lys Val Asn Val Asn
Gly Gly Ala Ile Ala Leu Gly His Pro Val 340 345 350 Gly Cys Ser Gly
Ala Arg Ile Leu Val Thr Leu Leu His Glu Met Gln 355 360 365 Lys Arg
Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly 370 375 380
Gln Gly Thr Ala Val Val Val Glu Arg 385 390 7391PRTClostridium
kluyveri 7Met Lys Asp Ala Val Ile Val Ser Ala Val Arg Thr Ala Ile
Gly Ser 1 5 10 15 Phe Gly Gly Thr Leu Lys Asp Ile Ser Ala Val Asp
Leu Gly Ala Ile 20 25 30 Val Ile Lys Glu Ala Val Lys Arg Ala Gly
Ile Lys Pro Glu Gln Val 35 40 45 Asp Glu Val Ile Phe Gly Asn Val
Ile Gln Ala Gly Leu Gly Gln Ser 50 55 60 Pro Ala Arg Gln Ala Ala
Val Lys Ala Gly Ile Pro Val Glu Val Pro 65 70 75 80 Ala Phe Thr Leu
Asn Lys Val Cys Gly Ser Gly Leu Arg Ser Val Ser 85 90 95 Leu Ala
Ala Gln Leu Ile Lys Ile Gly Asp Asp Asp Ile Val Val Val 100 105 110
Gly Gly Thr Glu Asn Met Ser Ala Ala Pro Tyr Leu Leu Pro Lys Ala 115
120 125 Arg Trp Gly His Arg Met Gly Glu Gly Lys Leu Val Asp Ala Met
Ile 130 135 140 Lys Asp Gly Leu Trp Glu Ala Phe Asn Asn Tyr His Met
Gly Ile Thr 145 150 155 160 Ala Glu Asn Ile Ala Glu Lys Trp Gly Ile
Thr Arg Asp Met Gln Asp 165 170 175 Glu Phe Ala Leu Ala Ser Gln Gln
Lys Ala Glu Ala Ala Ile Lys Ala 180 185 190 Gly Lys Phe Lys Asp Glu
Ile Val Pro Val Thr Val Lys Gln Lys Lys 195 200 205 Lys Glu Ile Ile
Phe Asp Thr Asp Glu Phe Pro Arg Phe Gly Thr Thr 210 215 220 Ile Glu
Ala Leu Ala Lys Leu Lys Pro Ser Phe Lys Lys Asp Gly Thr 225 230 235
240 Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Ala Ala Ala Ala Leu
245 250 255 Val Val Met Ser Ala Asp Lys Ala Lys Glu Leu Gly Ile Lys
Pro Leu 260 265 270 Ala Lys Ile Val Ser Tyr Gly Ser Lys Gly Leu Asp
Pro Thr Ile Met 275 280 285 Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Leu
Ala Leu Glu Lys Ala Asn 290 295 300 Leu Ser Ile Ala Asp Leu Asp Leu
Ile Glu Ala Asn Glu Ala Phe Ala 305 310 315 320 Ser Gln Ser Leu Ala
Val Ala Lys Asp Leu Glu Phe Asp Met Ser Lys 325 330 335 Val Asn Val
Asn Gly Gly Ala Ile Ala Leu Gly His Pro Val Gly Cys 340 345 350 Ser
Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Met Gln Arg Arg 355 360
365 Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Met Gly
370 375 380 Thr Ala Leu Ile Val Glu Arg 385 390 8391PRTClostridium
kluyveri 8Met Arg Glu Val Val Ile Val Ser Ala Val Arg Thr Ala Ile
Gly Ser 1 5 10 15 Phe Gly Gly Thr Leu Lys Asp Val Pro Ala Val Glu
Leu Gly Ala Val 20 25 30 Val Ile Lys Glu Ala Val Lys Arg Ala Asn
Val Lys Pro Glu Gln Ile 35 40 45 Asp Glu Val Ile Phe Gly Asn Val
Ile Gln Ala Gly Leu Gly Gln Ser 50 55 60 Pro Ala Arg Gln Ala Ala
Val Lys Ala Gly Ile Pro Val Glu Val Pro 65 70 75 80 Ala Phe Thr Leu
Asn Lys Val Cys Gly Ser Gly Leu Arg Ser Val Ser 85 90 95 Leu Ala
Ala Gln Val Ile Lys Ala Gly Asp Ala Asp Ile Val Val Val 100 105 110
Gly Gly Met Glu Asn Met Ser Ala Ala Pro Tyr Val Leu Pro Lys Ala 115
120 125 Arg Trp Gly His Arg Met Gly Glu Gly Lys Ile Val Asp Ala Met
Ile 130 135 140 Lys Asp Gly Leu Trp Glu Ala Phe Asn Asn Tyr His Met
Gly Ile Thr 145 150 155 160 Ala Glu Asn Ile Ala Glu Lys Trp Gly Leu
Thr Arg Glu Glu Gln Asp 165 170 175 Glu Phe Ser Ala Ala Ser Gln Gln
Lys Ala Glu Ala Ala Gln Lys Ala 180 185 190 Gly Lys Phe Lys Asp Glu
Ile Val Pro Val Thr Val Lys Ile Lys Lys 195 200 205 Lys Glu Val Val
Phe Asp Thr Asp Glu Tyr Ile Lys Pro Gly Thr Thr 210 215 220 Val Glu
Thr Leu Ala Lys Leu Arg Pro Ala Phe Lys Lys Asp Gly Thr 225 230 235
240 Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Ala Ala Ala Ala Leu
245 250 255 Val Val Met Ser Ala Asp Lys Ala Lys Glu Leu Gly Ile Lys
Pro Leu 260 265 270 Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Leu Asp
Pro Thr Ile Met 275 280 285 Gly Tyr Gly Pro Phe His Ala Thr Lys Ala
Ala Leu Glu Lys Ala Asn 290 295 300 Leu Ser Val Ala Asp Leu Asp Leu
Ile Glu Ala Asn Glu Ala Phe Ala 305 310 315 320 Ser Gln Ser Leu Ala
Val Ala Lys Asp Leu Glu Phe Asp Met Ser Lys 325 330 335 Val Asn Val
Asn Gly Gly Ala Ile Ala Leu Gly His Pro Val Gly Ala 340 345 350 Ser
Gly Ala Arg Ile Leu Val Thr Leu Leu His Glu Met Gln Arg Arg 355 360
365 Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Met Gly
370 375 380 Thr Ala Leu Ile Val Glu Arg 385 390
9408PRTCorynebacterium glutamicum 9Met Asn Pro Gln Asp Ile Val Ile
Cys Ser Pro Leu Arg Thr Pro Val 1 5 10 15 Gly Ala Tyr Gly Gly Ser
Phe Thr Gly Val Pro Val Glu Glu Leu Ala 20 25 30 Thr Thr Val Ile
Asn Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp 35 40 45 Asp Val
Asp Asp Leu Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala 50 55 60
Pro Ala Leu Gly Arg Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn 65
70 75 80 Val Pro Gly Met Gln Leu Asp Arg Arg Cys Gly Ser Gly Leu
Gln Ala 85 90 95 Ile Val Thr Ala Ala Ala His Val Ala Ser Gly Ala
Ala Asp Leu Ile 100 105 110 Ile Ala Gly Gly Ala Glu Ser Met Ser Arg
Val Glu Tyr Thr Val Ser 115 120 125 Gly Asp Ile Arg Trp Gly Val Lys
Gly Gly Asp Met Gln Leu Arg Asp 130 135 140 Arg Leu Ala Glu Ala Arg
Glu Thr Ala Gly Gly Arg Asn His Pro Ile 145 150 155 160 Pro Gly Gly
Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly 165 170 175 Ile
Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg 180 185
190 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro
195 200 205 Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile
Val Ser 210 215 220 Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu
Lys Leu Ala Ala 225 230 235 240 Leu Arg Pro Ile Met Gly Arg Gln Asp
Ala Glu Ala Thr Val Thr Ala 245 250 255 Gly Asn Ala Ser Gly Gln Asn
Asp Gly Ala Ala Ala Val Ile Val Thr 260 265 270 Thr Arg Ala Lys Ala
Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu 275 280 285 Ala Gly Trp
Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly 290 295 300 Pro
Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu 305 310
315 320 Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln
Ala 325 330 335 Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp
Glu Arg Val 340 345 350 Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His
Pro Val Gly Ala Thr 355 360 365 Gly Ala Arg Met Ala Val Thr Leu Ala
His Arg Met Gln Arg Glu Asn 370 375 380 Thr Gln Tyr Gly Leu Ala Thr
Met Cys Ile Gly Gly Gly Gln Gly Leu 385 390 395 400 Ala Ala Val Phe
Glu Lys Glu Asn 405 10401PRTEscherichia coli 10Met Arg Glu Ala Phe
Ile Cys Asp Gly Ile Arg Thr Pro Ile Gly Arg 1 5 10 15 Tyr Gly Gly
Ala Leu Ser Ser Val Arg Ala Asp Asp Leu Ala Ala Ile 20 25 30 Pro
Leu Arg Glu Leu Leu Val Arg Asn Pro Arg Leu Asp Ala Glu Cys 35 40
45 Ile Asp Asp Val Ile Leu Gly Cys Ala Asn Gln Ala Gly Glu Asp Asn
50 55 60 Arg Asn Val Ala Arg Met Ala Thr Leu Leu Ala Gly Leu Pro
Gln Ser 65 70 75 80 Val Ser Gly Thr Thr Ile Asn Arg Leu Cys Gly Ser
Gly Leu Asp Ala 85 90 95 Leu Gly Phe Ala Ala Arg Ala Ile Lys Ala
Gly Asp Gly Asp Leu Leu 100 105 110 Ile Ala Gly Gly Val Glu Ser Met
Ser Arg Ala Pro Phe Val Met Gly 115 120 125 Lys Ala Ala Ser Ala Phe
Ser Arg Gln Ala Glu Met Phe Asp Thr Thr 130 135 140 Ile Gly Trp Arg
Phe Val Asn Pro Leu Met Ala Gln Gln Phe Gly Thr 145 150 155 160 Asp
Ser Met Pro Glu Thr Ala Glu Asn Val Ala Glu Leu Leu Lys Ile 165 170
175 Ser Arg Glu Asp Gln Asp Ser Phe Ala Leu Arg Ser Gln Gln Arg Thr
180 185 190 Ala Lys Ala Gln Ser Ser Gly Ile Leu Ala Glu Glu Ile Val
Pro Val 195 200 205 Val Leu Lys Asn Lys Lys Gly Val Val Thr Glu Ile
Gln His Asp Glu 210 215 220 His Leu Arg Pro Glu Thr Thr Leu Glu Gln
Leu Arg Gly Leu Lys Ala 225 230 235 240 Pro Phe Arg Ala Asn Gly Val
Ile Thr Ala Gly Asn Ala Ser Gly Val 245 250 255 Asn Asp Gly Ala Ala
Ala Leu Ile Ile Ala Ser Glu Gln Met Ala Ala 260 265 270 Ala Gln Gly
Leu Thr Pro Arg Ala Arg Ile Val Ala Met Ala Thr Ala 275 280 285 Gly
Val Glu Pro Arg Leu Met Gly Leu Gly Pro Val Pro Ala Thr Arg 290 295
300 Arg Val Leu Glu Arg Ala Gly Leu Ser Ile His Asp Met Asp Val Ile
305 310 315 320 Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala Leu Gly Val
Leu Arg Glu 325 330 335 Leu Gly Leu Pro Asp Asp Ala Pro His Val Asn
Pro Asn Gly Gly Ala 340 345 350 Ile Ala Leu Gly His Pro Leu Gly Met
Ser Gly Ala Arg Leu Ala Leu 355 360 365 Ala Ala Ser His Glu Leu His
Arg Arg Asn Gly Arg Tyr Ala Leu Cys 370 375 380 Thr Met Cys Ile Gly
Val Gly Gln Gly Ile Ala Met Ile Leu Glu Arg 385 390 395 400 Val
11400PRTPseudomonas putida 11Met His Asp Val Phe Ile Cys Asp Ala
Ile Arg Thr Pro Ile Gly Arg 1 5 10 15 Phe Gly Gly Ala Leu Ala Ser
Val Arg Ala Asp Asp Leu Ala Ala Val 20 25 30 Pro Leu Lys Ala Leu
Ile Glu Arg Asn Pro Gly Val Gln Trp Asp Gln 35 40 45 Val Asp Glu
Val Phe Phe Gly Cys Ala Asn Gln Ala Gly Glu Asp Asn 50 55 60 Arg
Asn Val Ala Arg Met Ala Leu Leu Leu Ala Gly Leu Pro Glu Ser 65 70
75 80 Ile Pro Gly Val Thr Leu Asn Arg Leu Cys Ala Ser Gly Met Asp
Ala 85 90 95 Val Gly Thr Ala Phe Arg Ala Ile Ala Ser Gly Glu Met
Glu Leu Val 100 105 110 Ile Ala Gly Gly Val Glu Ser Met Ser Arg Ala
Pro Phe Val Met Gly 115 120 125 Lys Ala Glu Ser Ala Tyr Ser Arg Asn
Met Lys Leu Glu Asp Thr Thr 130 135 140 Ile Gly Trp Arg Phe Ile Asn
Pro Leu Met Lys Ser Gln Tyr Gly Val 145 150 155 160 Asp Ser Met Pro
Glu Thr Ala Asp Asn Val Ala Asp Asp Tyr Gln Val 165 170 175 Ser Arg
Ala Asp Gln Asp Ala Phe Ala Leu Arg Ser Gln Gln Lys Ala 180 185 190
Ala Ala Ala Gln Ala Ala Gly Phe Phe Ala Glu Glu Ile Val Pro Val 195
200 205 Arg Ile Ala His Lys Lys Gly Glu Ile Ile Val Glu Arg Asp Glu
His 210 215 220 Leu Arg Pro Glu Thr Thr Leu Glu Ala Leu Thr Lys Leu
Lys Pro Val 225 230 235 240 Asn Gly Pro Asp Lys Thr Val Thr Ala Gly
Asn Ala Ser Gly Val Asn 245 250 255 Asp Gly Ala Ala Ala Met Ile Leu
Ala Ser Ala Ala Ala Val Lys Lys 260 265 270 His Gly Leu Thr Pro Arg
Ala Arg Val Leu Gly Met Ala Ser Gly Gly 275 280 285 Val Ala Pro Arg
Val Met Gly Ile Gly Pro Val Pro Ala Val Arg Lys 290 295 300 Leu Thr
Glu Arg Leu Gly Ile Ala Val Ser Asp Phe Asp Val Ile Glu 305 310 315
320 Leu Asn Glu Ala Phe Ala Ser Gln Gly Leu Ala Val Leu Arg Glu Leu
325 330 335 Gly Val Ala Asp Asp Ala Pro Gln Val Asn Pro Asn Gly Gly
Ala Ile 340 345 350 Ala Leu Gly His Pro Leu Gly Met Ser Gly Ala Arg
Leu Val Leu Thr 355 360 365 Ala Leu His Gln Leu Glu Lys Ser Gly Gly
Arg Lys Gly Leu Ala Thr 370 375 380 Met Cys Val Gly Val Gly Gln Gly
Leu Ala Leu Ala Ile Glu Arg Val 385 390 395 400 12394PRTRalstonia
eutropha 12Met Thr Arg Glu Val Val Val Val Ser Gly Val Arg Thr Ala
Ile Gly 1 5 10 15 Thr Phe Gly Gly Ser Leu Lys Asp Val Ala Pro Ala
Glu Leu Gly Ala 20 25 30 Leu Val Val Arg Glu Ala Leu Ala Arg Ala
Gln Val Ser Gly Asp Asp 35 40 45 Val Gly His Val Val Phe Gly Asn
Val Ile Gln Thr Glu Pro Arg Asp 50 55 60 Met Tyr Leu Gly Arg Val
Ala Ala Val Asn Gly Gly Val Thr Ile Asn 65 70 75 80 Ala Pro Ala Leu
Thr Val Asn Arg Leu Cys Gly Ser Gly Leu Gln Ala 85 90 95 Ile Val
Ser Ala Ala Gln Thr Ile Leu Leu Gly Asp Thr Asp Val Ala 100
105 110 Ile Gly Gly Gly Ala Glu Ser Met Ser Arg Ala Pro Tyr Leu Ala
Pro 115 120 125 Ala Ala Arg Trp Gly Ala Arg Met Gly Asp Ala Gly Leu
Val Asp Met 130 135 140 Met Leu Gly Ala Leu His Asp Pro Phe His Arg
Ile His Met Gly Val 145 150 155 160 Thr Ala Glu Asn Val Ala Lys Glu
Tyr Asp Ile Ser Arg Ala Gln Gln 165 170 175 Asp Glu Ala Ala Leu Glu
Ser His Arg Arg Ala Ser Ala Ala Ile Lys 180 185 190 Ala Gly Tyr Phe
Lys Asp Gln Ile Val Pro Val Val Ser Lys Gly Arg 195 200 205 Lys Gly
Asp Val Thr Phe Asp Thr Asp Glu His Val Arg His Asp Ala 210 215 220
Thr Ile Asp Asp Met Thr Lys Leu Arg Pro Val Phe Val Lys Glu Asn 225
230 235 240 Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Ala
Ala Ala 245 250 255 Ala Val Val Met Met Glu Arg Ala Glu Ala Glu Arg
Arg Gly Leu Lys 260 265 270 Pro Leu Ala Arg Leu Val Ser Tyr Gly His
Ala Gly Val Asp Pro Lys 275 280 285 Ala Met Gly Ile Gly Pro Val Pro
Ala Thr Lys Ile Ala Leu Glu Arg 290 295 300 Ala Gly Leu Gln Val Ser
Asp Leu Asp Val Ile Glu Ala Asn Glu Ala 305 310 315 320 Phe Ala Ala
Gln Ala Cys Ala Val Thr Lys Ala Leu Gly Leu Asp Pro 325 330 335 Ala
Lys Val Asn Pro Asn Gly Ser Gly Ile Ser Leu Gly His Pro Ile 340 345
350 Gly Ala Thr Gly Ala Leu Ile Thr Val Lys Ala Leu His Glu Leu Asn
355 360 365 Arg Val Gln Gly Arg Tyr Ala Leu Val Thr Met Cys Ile Gly
Gly Gly 370 375 380 Gln Gly Ile Ala Ala Ile Phe Glu Arg Ile 385 390
13406PRTRhodococcus sp. 13Met Ala Glu Val Phe Leu Val Asp Gly Ala
Arg Thr Pro Gln Gly Arg 1 5 10 15 Tyr Gly Gly Ala Leu Ala Gly Val
Arg Pro Asp Asp Leu Ala Gly Leu 20 25 30 Val Val Ala Glu Ala Ala
Arg Arg Ala Gly Ile Pro Gly Asp Ala Val 35 40 45 Asp Glu Val Ile
Leu Gly Ala Ala Asn Gln Ala Gly Glu Asp Asn Arg 50 55 60 Asp Val
Ala Arg Met Ala Val Leu Leu Ala Gly Leu Pro Asp Ser Val 65 70 75 80
Pro Gly Tyr Thr Val Asn Arg Leu Cys Ala Ser Gly Leu Thr Ala Val 85
90 95 Ala Ser Ala Ala His Thr Ile Arg Ser Gly Glu Ala Asp Ile Val
Ile 100 105 110 Ala Gly Gly Val Glu Ser Met Thr Arg Ala Pro Trp Val
Met Ala Lys 115 120 125 Pro Gly Thr Pro Trp Ala Arg Pro Gly Glu Val
Ala Asp Thr Ser Leu 130 135 140 Gly Trp Arg Phe Thr Asn Pro Arg Phe
Thr Ala Ala Asp Arg Asp Val 145 150 155 160 Pro Ala Gly Ala Gly Pro
Asp Val Arg Lys Val Thr Leu Ser Met Gly 165 170 175 Glu Thr Ala Glu
Glu Val Ala Ala Leu Glu Gly Val Thr Arg Ala Glu 180 185 190 Ser Asp
Ala Phe Ala Leu Arg Ser Gln Glu Arg Ala Ile Ala Ala Val 195 200 205
Asp Ala Gly Arg Phe Glu Arg Glu Ile Val Pro Val Pro Val Arg Asp 210
215 220 Gly Glu Leu Ala Ala Asp Glu Thr Pro Arg Arg Gly Thr Thr Leu
Glu 225 230 235 240 Lys Leu Gly Ser Leu Lys Pro Val Phe Arg Thr Gly
Gly Ile Val Thr 245 250 255 Ala Gly Ser Ser Ser Ser Leu Ser Asp Gly
Ala Ala Ala Leu Val Val 260 265 270 Ala Ser Glu Ala Ala Val Glu Lys
Tyr Gly Leu Thr Val Arg Gly Arg 275 280 285 Ile Val Thr Ser Ala Ser
Ala Gly Ile Ala Pro Asn Val Met Gly Leu 290 295 300 Gly Pro Val Pro
Ala Thr Arg Lys Ala Leu Ala Arg Ala Asn Trp Ser 305 310 315 320 Ile
Ser Asp Leu Gly Ala Ala Glu Leu Asn Glu Ala Phe Ala Ala Gln 325 330
335 Ser Leu Gly Val Ile Arg Gln Leu Lys Leu Asp Glu Ser Ile Val Asn
340 345 350 Ala Asp Gly Gly Ala Ile Ala Leu Gly His Pro Leu Gly Cys
Ser Gly 355 360 365 Ala Arg Ile Leu Leu Thr Leu Leu Gly Arg Met Glu
Arg Glu Gly Ala 370 375 380 Arg Arg Gly Leu Ala Thr Leu Cys Val Gly
Val Gly Gln Gly Val Ala 385 390 395 400 Met Leu Ile Glu Ala Pro 405
14327PRTPenicillium chrysogenum 14Met Ser Ala Pro Gly Ala Gly His
Glu Phe Pro Ala Gln Glu Val Ser 1 5 10 15 Trp Gln Lys Arg Asp Val
Leu Leu Phe Ala Asn Ser Ile Gly Val Lys 20 25 30 Ala Asp Glu Leu
His Phe Leu Tyr Glu Leu His Pro Asn Phe Ala Val 35 40 45 Phe Pro
Thr Tyr Ser Leu Ile Leu Arg Met Ser Lys Asn Thr Ser Asp 50 55 60
Phe Arg Thr Ile Ala Leu Thr Pro Lys Pro Leu Ala Phe Lys Leu Thr 65
70 75 80 Asp Gln Glu Val Thr Asp Phe Tyr Ala Arg Gln Lys Ala Val
His Ile 85 90 95 Pro Gly Val Pro Asp Leu Asp His Arg His Gly Val
Asp Gly Gln Arg 100 105 110 Lys Ile Thr Ile Leu Lys Pro Leu Pro Thr
Thr Ser Ala Gly Arg Lys 115 120 125 Phe Glu Leu Arg Asn Lys Val Ile
Gly Val Tyr Asp Lys Gly Lys Pro 130 135 140 Gly Thr Val Ile Glu Thr
Glu Gln Ser Ile Val Asp Lys Glu Ser Gly 145 150 155 160 Glu Val Tyr
Ser Lys Val Val Ser Ser Gly Phe Leu Val Gly Gln Gly 165 170 175 Gly
Trp Gly Gly Pro Lys Gly Pro Ser Thr Val Asn Tyr Ala Pro Pro 180 185
190 Glu Gly Arg Ala Pro Asp Ala Thr His Val Val Gln Ser Asn Ser Glu
195 200 205 Thr Ala His Leu Tyr Arg Leu Asn Gly Asp Tyr Asn Pro Leu
His Ala 210 215 220 Thr Pro Glu Pro Gly Gln Lys Met Gly Phe Gly Gly
Ile Ile Ile His 225 230 235 240 Gly Leu Phe Ser Trp Asn Ser Ala Ala
His Gly Ile Leu Arg Glu Phe 245 250 255 Gly Gly Ser Asn Pro Ala Asn
Met Lys Glu Phe Gln Ala Arg Phe Ala 260 265 270 Ser Pro Val Arg Pro
Gly Asp Lys Leu Thr Thr Glu Ile Trp Arg Met 275 280 285 Gly Asn Ile
Gln Asp Gly Tyr Glu Glu Ile Arg Phe Val Thr Lys Asn 290 295 300 Asp
Lys Gly Arg Val Val Leu Ser Asn Gly Arg Cys Leu Leu Lys Val 305 310
315 320 Thr Gly Val Lys Ser Lys Leu 325 15901PRTPenicillium
chrysogenum 15Met Ser Glu Leu Arg Phe Asp Asn Gln Thr Val Val Val
Thr Gly Ala 1 5 10 15 Gly Gly Gly Leu Gly Lys Ala Tyr Ala Leu Phe
Phe Ala Ser Arg Gly 20 25 30 Ala Asn Val Val Val Asn Asp Leu Gly
Ala Ser His Lys Gly Glu Gly 35 40 45 Lys Ser Gly Lys Ala Ala Asp
Val Val Val Glu Glu Ile Arg Ala Ala 50 55 60 Gly Gly Lys Ala Val
Ala Asn Tyr Asp Ser Val Glu Asn Gly Asp Ala 65 70 75 80 Ile Ile Glu
Thr Ala Ile Lys Ala Phe Gly Arg Ile Asp Ile Leu Leu 85 90 95 Asn
Asn Ala Gly Ile Leu Arg Asp Ile Ser Phe Lys Asn Met Lys Asp 100 105
110 Ala Asp Trp Asp Leu Ile Asn Arg Val His Thr Tyr Gly Ala Tyr Lys
115 120 125 Cys Ala Arg Ala Ala Trp Pro His Phe Arg Lys Gln Lys Phe
Gly Arg 130 135 140 Val Ile Asn Thr Ala Ser Ala Ala Gly Leu Phe Gly
Ser Phe Gly Gln 145 150 155 160 Ala Asn Tyr Ser Ala Ala Lys Leu Gly
Gln Val Gly Phe Thr Glu Thr 165 170 175 Leu Ala Lys Glu Gly Ala Lys
Tyr Asn Ile Ile Ala Asn Val Ile Ala 180 185 190 Pro Ile Ala Ala Ser
Arg Met Thr Ala Thr Val Met Pro Pro Asp Val 195 200 205 Leu Glu Asn
Leu Lys Pro Asp Trp Val Val Pro Leu Val Ala Ala Leu 210 215 220 Val
His Ser Ser Asn Thr Thr Glu Thr Gly Gly Ile Tyr Glu Val Gly 225 230
235 240 Gly Gly His Val Ala Lys Leu Arg Trp Glu Arg Ala Lys Gly Ala
Leu 245 250 255 Leu Lys Thr Asp Asp Ser Leu Thr Pro Gly Ala Ile Ala
Arg Lys Trp 260 265 270 Asn Asp Val Asn Asp Phe Ser Gln Pro Glu Tyr
Pro Thr Gly Pro Ala 275 280 285 Asp Phe Met Ala Phe Leu Glu Asp Gly
Leu Lys Thr Pro Ser Ala Gln 290 295 300 Pro Gly Gln Glu Pro Asp Phe
Lys Gly Arg Val Ala Leu Val Thr Gly 305 310 315 320 Gly Gly Ala Gly
Leu Gly Arg Ala Tyr Cys Leu Gln Phe Ala Lys Leu 325 330 335 Gly Ala
Ser Val Val Val Asn Asp Leu Val Asp Pro Glu Pro Val Val 340 345 350
Gln Glu Ile Lys Lys Leu Gly Gly Lys Ala Val Gly Asn Lys Ala Ser 355
360 365 Cys Glu Asp Gly Asp Ala Val Val Lys Ser Ala Ile Asp Ala Phe
Gly 370 375 380 Arg Ile Asp Ile Leu Val Asn Asn Ala Gly Ile Leu Arg
Asp Lys Ala 385 390 395 400 Phe Thr Asn Met Asp Asp Asn Leu Trp Asn
Ser Val Val Asn Val His 405 410 415 Leu Arg Gly Thr Tyr Lys Val Thr
Lys Ala Ala Trp Pro Tyr Phe Leu 420 425 430 Lys Gln Lys Tyr Gly Arg
Val Val Asn Thr Ala Ser Thr Ser Gly Ile 435 440 445 Tyr Gly Asn Phe
Gly Gln Ala Asn Tyr Ala Ala Ala Lys Leu Gly Ile 450 455 460 Leu Gly
Leu Ser Arg Thr Leu Ala Leu Glu Gly Ala Lys Tyr Asn Ile 465 470 475
480 Lys Val Asn Thr Ile Ala Pro Asn Ala Gly Thr Asn Met Thr Arg Thr
485 490 495 Ile Met Pro Glu Glu Met Val Gln Ala Phe Lys Pro Asp Tyr
Val Ala 500 505 510 Pro Leu Val Val Leu Leu Cys Ser Asp Met Ala Pro
Glu Pro Ser Thr 515 520 525 Lys Gly Leu Phe Glu Cys Gly Ser Gly Trp
Phe Gly Arg Thr Arg Trp 530 535 540 Gln Arg Thr Gly Gly His Gly Phe
Pro Val Asp Val Lys Leu Thr Pro 545 550 555 560 Glu Glu Val Val Arg
Asn Trp Lys Gln Ile Ile Asn Phe Asp Asp Gly 565 570 575 Arg Ala Asp
His Pro Glu Asp Gly Gln Ala Gly Ala Glu Lys Ile Met 580 585 590 Ala
Asn Met Ser Asn Arg Val His Gly Asp Thr Ser Thr Glu Asn Glu 595 600
605 Thr Leu Lys Asn Ile Lys Lys Ala Lys Ala Leu Ser Ser Glu Gly Thr
610 615 620 Pro Phe Asn Tyr Glu Asp Arg Asp Val Ile Leu Tyr Asn Leu
Ser Leu 625 630 635 640 Gly Ala Lys Arg Thr Asp Leu Pro Leu Val Tyr
Glu Asn Asn Asp Gln 645 650 655 Phe Gln Ala Leu Pro Ser Tyr Gly Val
Val Pro Trp Phe Asn Thr Ala 660 665 670 Thr Pro Trp Asn Met Asp Asp
Leu Val Lys Asp Phe Ser Pro Met Met 675 680 685 Leu Leu His Gly Glu
Gln Tyr Met Glu Val Arg Lys Phe Pro Ile Pro 690 695 700 Thr Thr Ala
Asn Thr Leu Thr Tyr Pro Lys Leu Ile Asp Val Ile Asp 705 710 715 720
Lys Gly Asn Ala Ala Ile Val Val Ala Gly Tyr Thr Thr Lys Asp Ala 725
730 735 Lys Thr Gly Glu Asp Leu Phe Tyr Asn Glu Ser Ser Val Phe Ile
Arg 740 745 750 Gly Ser Gly Gly Phe Gly Gly Ser Pro Lys Pro Thr Ala
Val Arg Pro 755 760 765 Lys Ala Ala Thr Ala Ala Tyr Lys Ala Pro Gln
Arg Gln Pro Asp Ala 770 775 780 Val Val Glu Glu Lys Thr Ser Glu Asp
Gln Ala Ala Leu Tyr Arg Leu 785 790 795 800 Asn Gly Asp Arg Asn Pro
Leu His Ile Asp Pro Glu Phe Ser Lys Val 805 810 815 Gly Gly Phe Lys
Thr Pro Ile Leu His Gly Leu Cys Ser Leu Gly Val 820 825 830 Ser Ala
Lys Ala Val Phe Ser Lys Tyr Gly Pro Tyr Lys Asn Leu Lys 835 840 845
Val Arg Phe Ala Gly Val Val Leu Pro Gly Gln Thr Leu Lys Thr Glu 850
855 860 Met Trp Lys Glu Gly Asn Thr Val Leu Phe Gln Ala Thr Val Val
Glu 865 870 875 880 Thr Gly Lys Pro Ala Ile Thr Gly Ala Gly Ala Glu
Leu Leu Glu Gly 885 890 895 Ala Lys Ala Lys Leu 900
16319PRTPenicillium chrysogenum 16Met Leu Asn Ser Thr Leu Arg Phe
Val Ser Leu Arg Arg Gly Pro Thr 1 5 10 15 Val Ala Arg Asn Phe Cys
Ser Thr Ser Ala Val Arg Ala Ala Glu Val 20 25 30 Lys Ser Leu Gly
Val Val Gly Ala Gly Gln Met Gly Leu Gly Ile Ala 35 40 45 Leu Val
Ala Ala Gln Lys Ala Asn Val Pro Val Thr Leu Val Asp Thr 50 55 60
Ser Gln Ala Ser Leu Asp Lys Gly Leu Lys Phe Ala Asp Lys Leu Leu 65
70 75 80 Glu Lys Asp Val Ala Lys Gln Arg Leu Thr Arg Glu Ala Ala
Asp Glu 85 90 95 Ala Arg Gly Leu Ile Ser Thr Ser Leu Thr Leu Asp
Gly Leu Ser Ala 100 105 110 Val Asp Phe Val Ile Glu Ala Val Pro Glu
Ile Pro Asp Leu Lys Thr 115 120 125 Lys Ile Phe Ala Ser Leu Ala Gln
Ile Ala Pro Lys His Ala Ile Leu 130 135 140 Ala Thr Asn Thr Ser Ser
Ile Ser Ile Thr Lys Ile Ala Ala Ala Thr 145 150 155 160 Ser Ala Asp
Pro Thr Asp Leu Gln Ala Ser Ser Arg Val Ile Ser Thr 165 170 175 His
Phe Met Asn Pro Val Pro Ile Gln Lys Gly Val Glu Ile Ile Arg 180 185
190 Gly Leu Gln Thr Ser Glu Glu Thr Met Asp Thr Ala Ile Ala Phe Val
195 200 205 Gln Arg Met Gly Lys Val Ala Ser Val Ser Ala Asp Thr Pro
Gly Phe 210 215 220 Leu Ala Asn Arg Ile Leu Met Pro Tyr Ile Asn Glu
Ala Val Ile Cys 225 230 235 240 Leu Glu Thr Gly Val Gly Gln Arg Glu
Asp Ile Asp Asn Ile Met Lys 245 250 255 Thr Gly Thr Asn Val Pro Met
Gly Pro Leu Val Leu Ala Asp Phe Ile 260 265 270 Gly Leu Asp Thr Cys
Leu Ala Ile Met Asn Val Leu His Gln Asp Thr 275 280 285 Gly Asp Ser
Lys Tyr Arg Pro Ala Gly Leu Leu Arg Arg Met Val Asp 290 295 300 Ala
Gly Trp Leu Gly Lys Lys Ser Gly Lys Gly Phe Tyr Asp Tyr 305 310 315
17335PRTPenicillium chrysogenum 17Met Ala Thr Glu Tyr Pro His Arg
Ile Ala Leu Leu Gly Leu Gly Thr 1 5 10 15 Ile Gly Leu Ser Met Leu
Ala Met His Leu Arg Arg Pro Asp Thr Ser 20 25 30 Ile Thr Val Tyr
Asp Pro Arg Pro Asn Tyr Glu Ser Gln Ile Arg Ser 35
40 45 Thr Leu Pro Ser Leu Leu Asp Cys Pro Glu Ser Thr Thr Leu Ile
Asp 50 55 60 Asp Leu Leu Arg Thr Ser Arg Leu Lys Leu Ala Ser Thr
Val Ala Glu 65 70 75 80 Ala Ile Gln Asn Ala Asn Ile Ile Gln Glu Gln
Ser Pro Glu Val Thr 85 90 95 Ala Ser Lys Gln Ala Leu Trp Lys Glu
Val Ala Gly Leu Thr Gly Pro 100 105 110 Asp Val His Leu Trp Ser Ser
Ser Ser Gly Ile Ser Ala Ser Val Gln 115 120 125 Ala Ser Gly Cys Glu
Ala Ala Asp Arg Val Ala Glu Arg Leu Leu Val 130 135 140 Ala His Pro
Phe Asn Pro Pro His Leu Met Pro Leu Ile Glu Ile Val 145 150 155 160
Pro Gly Pro Glu Thr Asn Pro Glu Arg Val Glu Phe Val Arg Lys Tyr 165
170 175 Phe Gly Asp Val Pro Gly Pro Arg Ala Ser Gly Gly Asp Gln Ser
Ala 180 185 190 Ser Gln His Tyr Arg Pro Ile Thr Leu His Lys Glu Ile
Pro Gly Phe 195 200 205 Val Gly Asn Arg Leu Ala Phe Ala Leu Leu Arg
Glu Ala Cys Tyr Leu 210 215 220 Val Gly Glu Gly Val Val Ser Ala Lys
Asp Leu Asp Ser Leu Val Thr 225 230 235 240 Ala Ser Leu Gly Pro Arg
Trp Ala Gly Ser Gly Val Phe Glu Ser Tyr 245 250 255 His Ala Gly Gly
Gly Glu Gly Gly Ile Gly Ala Phe Leu Gln Lys Leu 260 265 270 Thr Pro
Thr Ile Gln Asp Val Trp Gly Glu Leu Gly Gln Ile Asp Ile 275 280 285
Gln Gly Glu Gln Thr Trp Lys Asp Val Val Val Lys Gln Thr Glu Asp 290
295 300 Ala Tyr Gly Pro Tyr Thr Pro Glu Thr Arg Lys Lys Lys Glu Glu
Met 305 310 315 320 Leu Arg Asp Val Val Glu Leu Gln Lys Lys Lys Trp
Gly Glu Leu 325 330 335 18505PRTAcinetobacter sp. 18Met Thr His Pro
Ile Lys Lys Ile Ala Ile Ile Gly Val Gly Val Met 1 5 10 15 Gly Ser
Gly Ile Ala Gln Ile Ala Ala Gln Ser Gly His Ile Thr Tyr 20 25 30
Leu Tyr Asp Ala Lys Ala Gly Ala Ala Gln Gln Ala Lys Gln Gln Leu 35
40 45 Ala Ile Thr Phe Gln Lys Leu Leu Asp Lys Asn Lys Ile Thr Thr
Glu 50 55 60 Tyr Ala Asp Ala Ala Asn Ala Asn Leu Leu Ile Ala Asn
Glu Leu His 65 70 75 80 Asp Leu Lys Asp Cys Asp Leu Ile Val Glu Ala
Ile Val Glu Arg Leu 85 90 95 Asp Ile Lys Gln Ser Leu Met Ser Gln
Leu Glu Ala Ile Val Pro Glu 100 105 110 Thr Thr Ile Leu Ala Ser Asn
Thr Ser Ser Leu Ser Ile Thr Ala Ile 115 120 125 Ala Ser Asn Cys Lys
His Pro Glu Arg Val Ala Gly Tyr His Phe Phe 130 135 140 Asn Pro Val
Pro Leu Met Lys Val Val Glu Val Ile Gln Gly Leu Lys 145 150 155 160
Thr Asp Pro Lys His Ile Glu Thr Leu Asn Gln Leu Ser Arg Val Leu 165
170 175 Gly His Arg Pro Val Val Ala Lys Asp Thr Pro Gly Phe Ile Ile
Asn 180 185 190 His Ala Gly Arg Ala Tyr Gly Thr Glu Ala Leu Lys Ile
Leu Asn Glu 195 200 205 Asn Val Thr Asp Ile Ser Glu Ile Asp Arg Ile
Leu Arg Asp Gly Val 210 215 220 Gly Phe Arg Met Gly Pro Phe Glu Leu
Met Asp Leu Thr Gly Leu Asp 225 230 235 240 Val Ser His Pro Val Met
Glu Ser Ile Tyr His Gln Tyr Tyr Glu Glu 245 250 255 Ala Arg Tyr Arg
Pro Asn Ser Leu Thr Lys Gln Met Leu Glu Ala Lys 260 265 270 Gln Leu
Gly Arg Lys Val Gly Gln Gly Phe Tyr Asp Tyr Arg Thr Gly 275 280 285
Ser Lys Thr Gly Glu Thr Ser Ala Lys Val Ala Glu Arg Leu Thr Leu 290
295 300 Tyr Pro Lys Val Trp Ile Ala Ala Asp Phe Glu Asp Asp Lys Gln
Leu 305 310 315 320 Leu Ile Asn Tyr Leu Thr Thr His Asn Ile Gln Leu
Asp Val Gly Ala 325 330 335 Lys Pro Gln Ala Asp Ser Leu Cys Leu Leu
Ala Cys Tyr Gly Glu Asp 340 345 350 Thr Thr His Ala Ala Leu Arg Leu
Asn Val Asn Pro Ala His Ser Val 355 360 365 Ala Ile Asp Met Leu Tyr
Gly Ile Glu Lys His Arg Thr Leu Met Pro 370 375 380 Ser Leu Ile Thr
Glu Val Thr Tyr Ser His Ala Ala His Ser Ile Phe 385 390 395 400 Asn
Leu Asp Gly Ala Met Val Ser Thr Ile Gly Glu Ser Ile Gly Phe 405 410
415 Val Ala Gln Arg Ile Leu Ala Met Val Ile Asn Leu Gly Cys Asp Ile
420 425 430 Ala Gln Gln Ala Ile Ala Ser Val Asp Asp Ile Asn Ala Ala
Val Arg 435 440 445 Leu Gly Leu Gly Tyr Pro Phe Gly Pro Ile Glu Trp
Gly Asp Glu Ile 450 455 460 Gly Ser Asn Lys Ile Leu Leu Ile Leu Asn
Arg Ile Thr Ala Leu Thr 465 470 475 480 Ser Asp Pro Arg Tyr Arg Pro
Ser Pro Trp Leu Gln Arg Arg Val Ala 485 490 495 Leu Asn Leu Pro Leu
Thr Phe Thr Thr 500 505 19282PRTClostridium kluyveri 19Met Ser Ile
Lys Ser Val Ala Val Leu Gly Ser Gly Thr Met Ser Arg 1 5 10 15 Gly
Ile Val Gln Ala Phe Ala Glu Ala Gly Ile Asp Val Ile Ile Arg 20 25
30 Gly Arg Thr Glu Gly Ser Ile Gly Lys Gly Leu Ala Ala Val Lys Lys
35 40 45 Ala Tyr Asp Lys Lys Val Ser Lys Gly Lys Ile Ser Gln Glu
Asp Ala 50 55 60 Asp Lys Ile Val Gly Arg Val Ser Thr Thr Thr Glu
Leu Glu Lys Leu 65 70 75 80 Ala Asp Cys Asp Leu Ile Ile Glu Ala Ala
Ser Glu Asp Met Asn Ile 85 90 95 Lys Lys Asp Tyr Phe Gly Lys Leu
Glu Glu Ile Cys Lys Pro Glu Thr 100 105 110 Ile Phe Ala Thr Asn Thr
Ser Ser Leu Ser Ile Thr Glu Val Ala Thr 115 120 125 Ala Thr Lys Arg
Pro Asp Lys Phe Ile Gly Met His Phe Phe Asn Pro 130 135 140 Ala Asn
Val Met Lys Leu Val Glu Ile Ile Arg Gly Met Asn Thr Ser 145 150 155
160 Gln Glu Thr Phe Asp Ile Ile Lys Glu Ala Ser Ile Lys Ile Gly Lys
165 170 175 Thr Pro Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn
Lys Ile 180 185 190 Leu Val Pro Met Ile Asn Glu Ala Val Gly Ile Leu
Ala Glu Gly Ile 195 200 205 Ala Ser Ala Glu Asp Ile Asp Thr Ala Met
Lys Leu Gly Ala Asn His 210 215 220 Pro Met Gly Pro Leu Ala Leu Gly
Asp Leu Ile Gly Leu Asp Val Val 225 230 235 240 Leu Ala Val Met Asp
Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr 245 250 255 Arg Ala His
Thr Leu Leu Arg Lys Tyr Val Arg Ala Gly Trp Leu Gly 260 265 270 Arg
Lys Ser Gly Lys Gly Phe Phe Ala Tyr 275 280 20319PRTClostridium
kluyveri 20Met Asp Ile Lys Asn Val Ala Val Leu Gly Thr Gly Thr Met
Gly Asn 1 5 10 15 Gly Ile Val Gln Leu Cys Ala Glu Ser Gly Leu Asn
Val Asn Met Phe 20 25 30 Gly Arg Thr Asp Ala Ser Leu Glu Arg Gly
Phe Thr Ser Ile Lys Thr 35 40 45 Ser Leu Lys Asn Leu Glu Glu Lys
Gly Lys Ile Lys Thr Asn Ile Ser 50 55 60 Lys Glu Ile Leu Lys Arg
Ile Lys Gly Val Lys Thr Ile Glu Glu Ala 65 70 75 80 Val Glu Gly Val
Asp Phe Val Ile Glu Cys Ile Ala Glu Asp Leu Glu 85 90 95 Leu Lys
Gln Glu Val Phe Ser Lys Leu Asp Glu Ile Cys Ala Pro Glu 100 105 110
Val Ile Leu Ala Ser Asn Thr Ser Gly Leu Ser Pro Thr Asp Ile Ala 115
120 125 Ile Asn Thr Lys His Pro Glu Arg Val Val Ile Ala His Phe Trp
Asn 130 135 140 Pro Pro Gln Phe Ile Pro Leu Val Glu Val Val Pro Gly
Lys His Thr 145 150 155 160 Asp Ser Lys Thr Val Asp Ile Thr Met Asp
Trp Ile Glu His Ile Gly 165 170 175 Lys Lys Gly Val Lys Met Arg Lys
Glu Cys Leu Gly Phe Ile Gly Asn 180 185 190 Arg Leu Gln Leu Ala Leu
Leu Arg Glu Ala Leu Tyr Ile Val Glu Gln 195 200 205 Gly Phe Ala Thr
Ala Glu Glu Val Asp Lys Ala Ile Glu Tyr Gly His 210 215 220 Gly Arg
Arg Leu Pro Val Thr Gly Pro Ile Cys Ser Ala Asp Leu Gly 225 230 235
240 Gly Leu Asp Ile Phe Asn Asn Ile Ser Ser Tyr Leu Phe Lys Asp Leu
245 250 255 Cys Asn Asp Thr Glu Pro Ser Lys Leu Leu Lys Ser Lys Val
Asp Gly 260 265 270 Gly Asn Leu Gly Ser Lys Thr Gly Lys Gly Phe Tyr
Asn Trp Thr Pro 275 280 285 Glu Phe Leu Gln Lys Lys Gln Asn Glu Arg
Ile Gln Leu Leu Met Asp 290 295 300 Phe Leu Glu Lys Asp Lys Asn Asp
Lys Ser Ile Glu Arg Asn Ile 305 310 315 21475PRTEscherichia coli
21Met Met Ile Asn Val Gln Thr Val Ala Val Ile Gly Ser Gly Thr Met 1
5 10 15 Gly Ala Gly Ile Ala Glu Val Ala Ala Ser His Gly His Gln Val
Leu 20 25 30 Leu Tyr Asp Ile Ser Ala Glu Ala Leu Thr Arg Ala Ile
Asp Gly Ile 35 40 45 His Ala Arg Leu Asn Ser Arg Val Thr Arg Gly
Lys Leu Thr Ala Glu 50 55 60 Thr Cys Glu Arg Thr Leu Lys Arg Leu
Ile Pro Val Thr Asp Ile His 65 70 75 80 Ala Leu Ala Ala Ala Asp Leu
Val Ile Glu Ala Ala Ser Glu Arg Leu 85 90 95 Glu Val Lys Lys Ala
Leu Phe Ala Gln Leu Ala Glu Val Cys Pro Pro 100 105 110 Gln Thr Leu
Leu Thr Thr Asn Thr Ser Ser Ile Ser Ile Thr Ala Ile 115 120 125 Ala
Ala Glu Ile Lys Asn Pro Glu Arg Val Ala Gly Leu His Phe Phe 130 135
140 Asn Pro Ala Pro Val Met Lys Leu Val Glu Val Val Ser Gly Leu Ala
145 150 155 160 Thr Ala Ala Glu Val Val Glu Gln Leu Cys Glu Leu Thr
Leu Ser Trp 165 170 175 Gly Lys Gln Pro Val Arg Cys His Ser Thr Pro
Gly Phe Ile Val Asn 180 185 190 Arg Val Ala Arg Pro Tyr Tyr Ser Glu
Ala Trp Arg Ala Leu Glu Glu 195 200 205 Gln Val Ala Ala Pro Glu Val
Ile Asp Ala Ala Leu Arg Asp Gly Ala 210 215 220 Gly Phe Pro Met Gly
Pro Leu Glu Leu Thr Asp Leu Ile Gly Gln Asp 225 230 235 240 Val Asn
Phe Ala Val Thr Cys Ser Val Phe Asn Ala Phe Trp Gln Glu 245 250 255
Arg Arg Phe Leu Pro Ser Leu Val Gln Gln Glu Leu Val Ile Gly Gly 260
265 270 Arg Leu Gly Lys Lys Ser Gly Leu Gly Val Tyr Asp Trp Arg Ala
Glu 275 280 285 Arg Glu Ala Val Val Gly Leu Glu Ala Val Ser Asp Ser
Phe Ser Pro 290 295 300 Met Lys Val Glu Lys Lys Ser Asp Gly Val Thr
Glu Ile Asp Asp Val 305 310 315 320 Leu Leu Ile Glu Thr Gln Gly Glu
Thr Ala Gln Ala Leu Ala Ile Arg 325 330 335 Leu Ala Arg Pro Val Val
Val Ile Asp Lys Met Ala Gly Lys Val Val 340 345 350 Thr Ile Ala Ala
Ala Ala Val Asn Pro Asp Ser Ala Thr Arg Lys Ala 355 360 365 Ile Tyr
Tyr Leu Gln Gln Gln Gly Lys Thr Val Leu Gln Ile Ala Asp 370 375 380
Tyr Pro Gly Met Leu Ile Trp Arg Thr Val Ala Met Ile Ile Asn Glu 385
390 395 400 Ala Leu Asp Ala Leu Gln Lys Gly Val Ala Ser Glu Gln Asp
Ile Asp 405 410 415 Thr Ala Met Arg Leu Gly Val Asn Tyr Pro Tyr Gly
Pro Leu Ala Trp 420 425 430 Gly Ala Gln Leu Gly Trp Gln Arg Ile Leu
Arg Leu Leu Glu Asn Leu 435 440 445 Gln His His Tyr Gly Glu Glu Arg
Tyr Arg Pro Cys Ser Leu Leu Arg 450 455 460 Gln Arg Ala Leu Leu Glu
Ser Gly Tyr Glu Ser 465 470 475 22320PRTEuglena gracilis 22Met Met
Ser Arg Asn Val Phe Thr Cys Cys Arg Ala Ile Arg Thr Tyr 1 5 10 15
Ala Thr Ala Pro Gly Leu Ser Thr Val Gly Val Val Gly Met Gly Ala 20
25 30 Met Gly His Gly Ile Ala Gln Met Thr Ala Ala Ala Gly Tyr Lys
Val 35 40 45 Val Ala Val Asp Ile Asp Ala Asn Met Leu Ser Lys Gly
Ile Lys Ala 50 55 60 Val Glu Asp Ser Leu Ser Lys Val Ala Ala Lys
Ala Val Lys Asp Gly 65 70 75 80 Lys Ala Asp Lys Ala Thr Ala Glu Lys
Asn Ala Ala Asp Val Arg Ser 85 90 95 Arg Ile Thr Thr Ser Gly Asp
Ile Gly Ala Leu Ser Ser Cys Asp Leu 100 105 110 Val Ile Glu Ser Ile
Ile Glu Asp Leu Asn Ile Lys Lys Lys Phe Phe 115 120 125 Ala Asp Leu
Gly Lys Val Ala Gly Ala Asn Ala Ile Leu Ala Ser Asn 130 135 140 Thr
Ser Ser Phe Pro Ile Thr Gln Leu Gly Glu Ala Ser Gly Arg Thr 145 150
155 160 Ser Asn Phe Leu Gly Leu His Phe Phe Asn Pro Val Gln Met Met
Lys 165 170 175 Leu Val Glu Val Ile Lys Thr Lys Asp Thr Lys Glu Asp
Val Tyr Lys 180 185 190 Leu Gly Phe Ala Phe Ser Lys Ser Ile Gly Lys
Glu Pro Val Ala Cys 195 200 205 Gly Asp Thr Pro Gly Phe Ile Val Asn
Arg Leu Leu Val Pro Phe Leu 210 215 220 Ala Gln Gly Leu Leu Met Leu
Asp Arg Gly Val Ala Ser Val Gln Asp 225 230 235 240 Ile Asp Val Ala
Met Met Tyr Gly Ala Gly Met Pro Met Gly Pro Leu 245 250 255 Thr Leu
Ala Asp Tyr Val Gly Leu Asp Val Cys Met His Ile Leu Glu 260 265 270
Gly Trp Thr Ser Gln Tyr Pro Asn Glu Pro Ala Phe Val Ile Pro Gln 275
280 285 Pro Leu Lys Ala Lys Val Ala Ala Gly Lys Leu Gly Arg Lys Thr
Gly 290 295 300 Glu Gly Phe Trp Lys Trp Glu Gly Asp Lys Pro Val Ala
Pro Ala Ala 305 310 315 320 23505PRTPseudomonas putida 23Met Ala
Ala Leu Ala Ser Asn Val Gln Val Ala Val Ile Gly Ala Gly 1 5 10 15
Ala Met Gly Ala Gly Ile Ala Gln Val Ala Ala Gln Ala Gly His Pro 20
25 30 Val Lys Leu Tyr Asp Asn Arg Pro Gly Ala Ala Ala Gln Ala Val
Thr 35 40 45 Gly Ile Asp Arg Gln Leu Ala Arg Leu Val Asp Lys Gly
Lys Leu Leu 50 55 60 Ala Ala Glu Arg Glu Thr Ile Asn Ala Arg Leu
Cys Pro Val Asp Thr 65 70 75 80 Leu Glu Ala Leu Ala Asp Ala Gly Leu
Val Ile Glu Ala Ile Val Glu 85
90 95 Asn Leu Gln Val Lys Gln Ala Leu Phe Ser Gln Leu Glu Thr Leu
Cys 100 105 110 Ala Ala Asp Cys Ile Leu Ala Ser Asn Thr Ser Ser Leu
Ser Ile Thr 115 120 125 Ser Leu Ala Ala Gly Leu Glu Arg Pro Gln His
Val Val Gly Met His 130 135 140 Phe Phe Asn Pro Ala Pro Leu Met Ala
Leu Val Glu Val Val Ser Gly 145 150 155 160 Leu Ala Thr Asp Pro Ala
Val Ala Ala Cys Ile Tyr Ala Thr Ala Gln 165 170 175 Ala Trp Gly Lys
Gln Pro Val His Ala Arg Ser Thr Pro Gly Phe Ile 180 185 190 Val Asn
Arg Val Ala Arg Pro Phe Tyr Ala Glu Ser Leu Arg Leu Leu 195 200 205
Gln Glu Gly Ala Ala Asp Cys Ala Ser Leu Asp Ala Leu Met Arg Asp 210
215 220 Ser Gly Gly Phe Arg Met Gly Ala Phe Glu Leu Thr Asp Leu Ile
Gly 225 230 235 240 His Asp Val Asn Tyr Ala Val Thr Cys Ser Val Phe
Asp Ala Phe Tyr 245 250 255 Gly Asp Phe Arg Phe Gln Pro Ser Leu Val
Gln Lys Glu Leu Val Asp 260 265 270 Ala Gly His Leu Gly Arg Lys Thr
Gly Gln Gly Phe Tyr Arg Tyr Ala 275 280 285 Glu Gly Val Glu Arg Pro
Gln Pro Ala Glu Leu His Ser Ser Ala Cys 290 295 300 Ala Glu Ala Cys
Val Val Glu Gly Asn Leu Gly Val Met Gln Pro Leu 305 310 315 320 Val
Glu Arg Leu Arg Gln Ser Gly Ile Ala Val Thr Gln Arg Ala Gly 325 330
335 Ser Gly Leu Ile Gln Val Gly Asp Ala Thr Leu Ala Leu Ser Asp Gly
340 345 350 Arg Leu Ala Ser Gln Arg Ala Arg Glu Asp Gly Leu Arg Asn
Leu Val 355 360 365 Leu Leu Asp Leu Ala Leu Asp Tyr Ser Ser Ala Thr
Arg Ile Ala Ile 370 375 380 Ser Trp Ser Ala Asp Thr Ser Asp Ser Ala
Arg Asp Gln Ala Val Ala 385 390 395 400 Leu Leu Gln Arg Ala Gly Leu
Lys Val Thr Gly Val Ala Asp Leu Pro 405 410 415 Gly Leu Val Val Leu
Arg Thr Val Ala Met Leu Ala Asn Glu Ala Ala 420 425 430 Asp Ala Val
Leu Gln Gly Val Gly Ser Ala Ala Asp Ile Asp Leu Ala 435 440 445 Met
Arg Ala Gly Val Asn Tyr Pro Cys Gly Pro Leu Ala Trp Ala Ala 450 455
460 Asn Ile Gly Ile Ala His Thr Leu Arg Val Leu Asp Asn Leu Gln Cys
465 470 475 480 Ser Tyr Gly Glu Ser Arg Tyr Arg Pro Ser Leu Leu Leu
Arg Arg Cys 485 490 495 Glu Ala Lys Gly Gly Thr Leu His Asp 500 505
24246PRTCupriavidus necator 24Met Thr Gln Arg Ile Ala Tyr Val Thr
Gly Gly Met Gly Gly Ile Gly 1 5 10 15 Thr Ala Ile Cys Gln Arg Leu
Ala Lys Asp Gly Phe Arg Val Val Ala 20 25 30 Gly Cys Gly Pro Asn
Ser Pro Arg Arg Glu Lys Trp Leu Glu Gln Gln 35 40 45 Lys Ala Leu
Gly Phe Asp Phe Ile Ala Ser Glu Gly Asn Val Ala Asp 50 55 60 Trp
Asp Ser Thr Lys Thr Ala Phe Asp Lys Val Lys Ser Glu Val Gly 65 70
75 80 Glu Val Asp Val Leu Ile Asn Asn Ala Gly Ile Thr Arg Asp Val
Val 85 90 95 Phe Arg Lys Met Thr Arg Ala Asp Trp Asp Ala Val Ile
Asp Thr Asn 100 105 110 Leu Thr Ser Leu Phe Asn Val Thr Lys Gln Val
Ile Asp Gly Met Ala 115 120 125 Asp Arg Gly Trp Gly Arg Ile Val Asn
Ile Ser Ser Val Asn Gly Gln 130 135 140 Lys Gly Gln Phe Gly Gln Thr
Asn Tyr Ser Thr Ala Lys Ala Gly Leu 145 150 155 160 His Gly Phe Thr
Met Ala Leu Ala Gln Glu Val Ala Thr Lys Gly Val 165 170 175 Thr Val
Asn Thr Val Ser Pro Gly Tyr Ile Ala Thr Asp Met Val Lys 180 185 190
Ala Ile Arg Gln Asp Val Leu Asp Lys Ile Val Ala Thr Ile Pro Val 195
200 205 Lys Arg Leu Gly Leu Pro Glu Glu Ile Ala Ser Ile Cys Ala Trp
Leu 210 215 220 Ser Ser Glu Glu Ser Gly Phe Ser Thr Gly Ala Asp Phe
Ser Leu Asn 225 230 235 240 Gly Gly Leu His Met Gly 245
25284PRTRhodococcus sp. 25Met Thr Ser Thr Ala Pro Lys Asn Val Gly
Val Val Gly Gly Gly Arg 1 5 10 15 Met Gly Ala Gly Ile Ala Gln Val
Phe Ala Thr Leu Gly Ser Thr Val 20 25 30 Ile Ile Ala Glu Ser Gly
Asp Arg Glu Ala Ala Val Lys Arg Val Ser 35 40 45 Asp Gly Leu Asp
Arg Ala His Glu Arg Gly Lys Leu Gly Asp Val Asp 50 55 60 Pro Ala
Thr Ile Leu Gly Arg Val Ser Thr Val Ala Ala Pro Asp Ala 65 70 75 80
Leu Pro Pro Ala Leu Asp Leu Val Val Glu Ala Val Pro Glu Leu Val 85
90 95 Asp Leu Lys Leu Ser Val Leu Ser Leu Val Glu Lys Thr Val Ser
Pro 100 105 110 Thr Thr Val Ile Ala Ser Asn Thr Ser Ser Ile Ser Ile
Ala Glu Leu 115 120 125 Gly Ser Ala Leu Gly Asp Pro Ala Arg Leu Ile
Gly Met His Phe Phe 130 135 140 Asn Pro Val Pro Ala Ser Ser Leu Val
Glu Ile Val Arg Ala Pro Ala 145 150 155 160 Thr Asp Ala Gly Val Val
Glu Lys Val Arg Glu Trp Val Ala Gln Leu 165 170 175 Gly Lys Thr Glu
Val Leu Val Asn Asp Ser Pro Gly Phe Ala Thr Ser 180 185 190 Arg Leu
Gly Val Cys Leu Gly Leu Glu Ala Ile Arg Met Leu Glu Glu 195 200 205
Gly Val Ala Asp Ala Glu Ser Ile Asp Arg Ala Met Glu Leu Gly Tyr 210
215 220 Arg His Pro Met Gly Pro Leu Arg Ser Thr Asp Leu Val Gly Leu
Asp 225 230 235 240 Val Arg Leu Ala Ile Ala Glu His Leu Ala Lys Thr
Leu Gly Asp Arg 245 250 255 Phe Ala Pro Pro Ala Leu Leu Arg Glu Lys
Val Ala Lys Gly Glu Leu 260 265 270 Gly Arg Lys Thr Gly Gln Gly Phe
Phe Thr Trp Ser 275 280 26699PRTRhodopseudomonas palustris 26Met
Ser Glu Val Val Thr Arg Ala Thr Gln Asp Gln Val Ala Ile Val 1 5 10
15 Thr Val Asp Ser Pro Pro Val Asn Ala Leu Ser Ala Ala Val Arg Arg
20 25 30 Gly Ile Leu Glu Asn Val Asn Ala Ala Val Ala Asp Pro Ala
Val Gln 35 40 45 Ala Ile Val Leu Val Cys Ala Gly Arg Thr Phe Ile
Ala Gly Ala Asp 50 55 60 Ile Thr Glu Phe Gly Lys Pro Pro Gln Pro
Pro Ala Leu Asn Asp Val 65 70 75 80 Ile Ala Ala Leu Glu Asn Ser Pro
Lys Pro Thr Ile Ala Ala Ile His 85 90 95 Gly Thr Ala Leu Gly Gly
Gly Leu Glu Val Ala Leu Gly Cys His Phe 100 105 110 Arg Val Ala Val
Lys Glu Ala Lys Leu Gly Leu Pro Glu Val Lys Leu 115 120 125 Gly Leu
Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Arg Ala Val 130 135 140
Gly Pro Glu Leu Ala Val Gln Met Ile Val Gly Gly Ser Pro Ile Gly 145
150 155 160 Ala Ala Glu Ala Leu Lys His Gly Leu Val Glu Glu Val Val
Glu Asn 165 170 175 Leu Val Ala Gly Ala Val Ala Phe Ala Lys Lys Val
Leu Ala Glu Lys 180 185 190 Arg Pro Leu Arg Arg Leu Arg Asp Asp Asp
Ser Lys Leu Ala Ala Ala 195 200 205 Lys Ala Asp Arg Ser Ile Phe Thr
Asn Ala Val Ala Ala Met Thr Lys 210 215 220 Lys Ala Arg Gly Leu Glu
Ala Pro Phe Ala Cys Ala Asp Ala Ile Gly 225 230 235 240 Ala Ala Ile
Asp Leu Pro Phe Glu Glu Gly Leu Lys Lys Glu Arg Glu 245 250 255 Gly
Phe Met Lys Leu Val Val Ser Asp Gln Ser Lys Ala Gln Arg Tyr 260 265
270 Ala Phe Phe Ala Glu Arg Glu Ala Ala Lys Val Asp Gly Val Pro Asp
275 280 285 Gly Thr Lys Pro Arg Pro Val Ser Arg Val Ala Ile Ile Gly
Ala Gly 290 295 300 Thr Met Gly Gly Gly Ile Ala Met Ser Phe Ala Asn
Ala Gly Ile Pro 305 310 315 320 Val Thr Leu Ile Glu Thr Gly Glu Glu
Gln Leu Lys Arg Gly Leu Gly 325 330 335 Ile Met Gln Lys Asn Trp Glu
Ala Thr Ala Ala Arg Gly Gly Leu Pro 340 345 350 Pro Asp Ala Pro Ala
Lys Arg Met Ala Leu Ile Thr Gly Leu Val Gly 355 360 365 Leu Glu Asn
Val Lys Asp Ala Asp Leu Ile Ile Glu Ala Val Phe Glu 370 375 380 Thr
Met Ala Val Lys Lys Glu Val Phe Thr Ala Val Asp Ala His Ala 385 390
395 400 Lys Pro Gly Ala Val Leu Ala Ser Asn Thr Ser Tyr Leu Ser Ile
Asp 405 410 415 Glu Ile Ala Ala Thr Thr Lys Arg Pro Gln Asp Val Leu
Gly Met His 420 425 430 Phe Phe Ser Pro Ala Asn Val Met Lys Leu Cys
Glu Ile Val Arg Gly 435 440 445 Ala Lys Thr Ala Pro Asp Ala Leu Leu
Thr Ala Val Ser Ile Ala Lys 450 455 460 Lys Ile Ala Lys Val Pro Val
Val Val Gly Val Cys Asp Gly Phe Val 465 470 475 480 Gly Asn Arg Met
Leu Ala Ala Arg Ser Lys Gln Ser Glu Lys Leu Leu 485 490 495 Phe Glu
Gly Ala Leu Pro Gln Gln Val Asp Ala Val Val Thr Lys Phe 500 505 510
Gly Met Pro Met Gly Pro Phe Ala Met Gly Asp Leu Ala Gly Leu Asp 515
520 525 Ile Gly Trp Arg Ser Arg Lys Asp Arg Gly Ile Lys Ser Glu Ile
Ala 530 535 540 Asp Ala Leu Cys Glu Ala Gly Arg Phe Gly Gln Lys Thr
Gly Lys Gly 545 550 555 560 Tyr Tyr Lys Tyr Glu Gln Gly Ser Arg Ala
Pro Met Pro Asp Pro Glu 565 570 575 Val Glu Thr Leu Ile Asn Asp Thr
Leu Ala Lys Leu Gly Leu Lys Arg 580 585 590 Arg Asp Ile Thr Asp Glu
Glu Ile Leu Glu Arg Met Val Tyr Pro Met 595 600 605 Ile Asn Glu Gly
Ala Arg Ile Leu Glu Glu Lys Ile Ala Ala Arg Pro 610 615 620 Ser Asp
Ile Asp Val Val Trp Leu Tyr Gly Tyr Gly Trp Pro Ile Tyr 625 630 635
640 Arg Gly Gly Pro Met His Tyr Ala Asp Ser Val Gly Leu Lys His Ile
645 650 655 Ala Glu Arg Leu Ser Ala Tyr Ala Lys Ala Thr Asn Asp Pro
Ser Leu 660 665 670 Glu Pro Ala Pro Leu Leu Ala Arg Leu Ala Ala Glu
Gly Lys Thr Phe 675 680 685 Ala Ser Leu Thr Gln Pro Ser Lys Ala Ala
Ala 690 695 27278PRTPenicillium chrysogenum 27Met Ser Leu Leu Thr
Thr Tyr Thr Thr Gln Asn Thr Thr Lys Ile Ala 1 5 10 15 His Leu Thr
Ile Ser His Ala Gln Lys Leu Asn Ser Leu Thr Thr Pro 20 25 30 Leu
Leu Thr Ser Leu Thr Gln Thr Leu Ser Lys Leu Ser Asn Thr Asn 35 40
45 Leu His Ala Ile Thr Leu Thr Gly Ala Gly Gln Lys Ser Phe Ile Gly
50 55 60 Gly Ala Asp Leu Asn Glu Leu Ser Thr Leu Arg Asn Ala Pro
Thr Ala 65 70 75 80 Arg Lys Phe Ile Thr Ser Val His Glu Thr Cys Thr
Ala Ile Arg Thr 85 90 95 Cys Pro Val Pro Val Ile Ala Arg Ile Asn
Gly Phe Ala Leu Gly Ala 100 105 110 Gly Leu Glu Ile Ala Ala Ala Cys
Asp Leu Arg Val Ala Ala Lys Gly 115 120 125 Ala Val Phe Gly Met Pro
Glu Val Arg Leu Gly Ile Pro Ser Val Val 130 135 140 Glu Ala Ala Leu
Leu Pro Gly Leu Ile Gly Trp Gly Arg Thr Arg Gln 145 150 155 160 Leu
Leu Leu Leu Gly Gly Met Ile Ser Ala Ser Glu Ala Leu Arg Trp 165 170
175 Gly Leu Val Glu Arg Val Val Glu Asp Glu Glu Leu Asp Leu Ala Val
180 185 190 Ala Glu Trp Thr Ser Glu Ile Gly Arg Asn Gly Pro Leu Ala
Val Arg 195 200 205 Arg Gln Lys Ala Leu Ile Ser Arg Trp Glu Glu Leu
Ser Leu Ala Gly 210 215 220 Gly Ile Glu Ala Gly Ile Glu Ala Phe Gly
Glu Cys Phe Asp Gly Asp 225 230 235 240 Cys Gly Thr Glu Pro Gly Arg
Met Ile Gly Glu Phe Phe Arg Glu Lys 245 250 255 Glu Arg Ser Lys Ala
Arg Ile Glu Ala Arg Asn Lys Val Val Ala Gly 260 265 270 Ser Lys Gly
Glu Glu Gly 275 28244PRTPenicillium chrysogenum 28Met Thr Glu Ile
Pro Thr Phe His Asn Leu Ser Leu Glu Arg His Gly 1 5 10 15 Asn Val
Phe Val Leu Thr Met Gln Lys Pro Pro Glu Asn Arg Leu Asn 20 25 30
Ser Ser Tyr Cys Gln Glu Met Ile Arg Ala Tyr Arg Ser Val Glu Arg 35
40 45 Ile Leu Gly Ser Asp Ser Glu Gly Ala Val Ile Thr Arg Gly Asn
Asp 50 55 60 Ala Lys Phe Trp Cys Thr Gly Leu Glu Leu Asp Glu Ser
Asp Ser Asn 65 70 75 80 Pro Phe Ala Asn Thr Asp Gly Phe Tyr Pro Leu
Ile His Thr Ile Leu 85 90 95 Asp Phe Pro Phe Pro Thr Val Ala Leu
Leu Thr Gly His Thr Phe Gly 100 105 110 Gly Ala Cys Pro Leu Ala Leu
Ala His Asp Tyr Arg Ile Met Asn Ser 115 120 125 Arg Arg Gly Phe Ile
Ser Met Pro Pro Val Asn Leu Gly Leu His Phe 130 135 140 Asp Gly Ile
Gly Ser Leu Pro Arg Leu Lys Leu Arg Pro Gln Val Ala 145 150 155 160
Arg Lys Met Leu Leu Glu Ala His Arg Trp Thr Gly Pro Glu Ala Leu 165
170 175 Glu Asp Gly Ile Val Asp Ala Val Ala Glu Pro Glu Asp Met Leu
Asn 180 185 190 Val Ala Leu Glu Leu Gly Ala Lys Trp Ala Pro Lys Ala
Lys Met Gly 195 200 205 Val Tyr Ala Leu Leu Arg Gln Glu Leu Trp Gly
Asp Ala Ile Lys Lys 210 215 220 Phe Gln Arg Ile Ser Tyr Val His Ser
Arg Val Thr Ser Ala Pro Ala 225 230 235 240 Lys Val Lys Ile
29300PRTPenicillium chrysogenum 29Met Ala Pro Ser Asp Arg Leu Thr
Gln Val Asn Glu His Leu Asn Tyr 1 5 10 15 Pro Ala Gly Leu Leu Ala
Gly Gln Val Ala Ile Ile Thr Gly Ala Gly 20 25 30 Gln Gly Ile Gly
Ala Glu Ala Ala Arg Leu Phe Ala Asn Glu Gly Ala 35 40 45 Lys Val
Val Val Ala Asp Ile Asp Ser Lys Lys Ala Asn Ala Val Ala 50 55 60
Asp Ala Ile Asn Ser Ala Lys Ala Gly Arg Ala Leu Ala Val Val Gly 65
70 75 80 Asp Val Leu Asp Ser Asn Tyr Ile Thr Glu Leu Val Lys Lys
Thr Ala 85 90 95 Glu Phe Gly Asn Gly Lys Ile His Ile Ile Val Asn
Asn Ala Gly Phe 100 105 110 Thr Trp Asp Gly Val Ile His Lys Met
Thr Asp Lys Gln Trp Glu Thr 115 120 125 Met Leu Ala Val His Asn Thr
Ala Pro Phe Gln Leu Val Arg Ala Ala 130 135 140 Ala Pro Tyr Phe Arg
Val Lys Asp Gln Glu Pro Arg Val Val Ile Asn 145 150 155 160 Ile Ser
Ser Thr Ser Gly Val His Gly Asn Ala Gly Gln Ala Asn Tyr 165 170 175
Ala Val Ala Lys Ala Gly Val Val Gly Leu Thr Arg Thr Ile Ala Lys 180
185 190 Glu Trp Gly Pro Ser Phe Gly Val Arg Ser Asn Thr Ile Ala Phe
Gly 195 200 205 Phe Val Thr Thr Arg Leu Thr Ala Ala Lys Glu Glu Gly
Ala Phe Ile 210 215 220 Thr Thr Pro Asp Gly Thr Lys Val Ala Leu Gly
Ile Pro Gly Lys Gln 225 230 235 240 Leu Ala Thr Lys Lys Gly Ser Ala
Asp Gln Glu Lys Lys Ala Ala Pro 245 250 255 Thr Tyr Pro Asp Ile Pro
Leu Gly Arg Pro Ala Thr Pro Glu Glu Ala 260 265 270 Ala Arg Ala Val
Leu Gly Val Ala Ser Pro Trp Phe Ser Tyr Val Asn 275 280 285 Gly Glu
Thr Ile Arg Val Thr Gly Gly Arg Asn Met 290 295 300
30327PRTPenicillium chrysogenum 30Met Ser Ala Pro Gly Ala Gly His
Glu Phe Pro Ala Gln Glu Val Ser 1 5 10 15 Trp Gln Lys Arg Asp Val
Leu Leu Phe Ala Asn Ser Ile Gly Val Lys 20 25 30 Ala Asp Glu Leu
His Phe Leu Tyr Glu Leu His Pro Asn Phe Ala Val 35 40 45 Phe Pro
Thr Tyr Ser Leu Ile Leu Arg Met Ser Lys Asn Thr Ser Asp 50 55 60
Phe Arg Thr Ile Ala Leu Thr Pro Lys Pro Leu Ala Phe Lys Leu Thr 65
70 75 80 Asp Gln Glu Val Thr Asp Phe Tyr Ala Arg Gln Lys Ala Val
His Ile 85 90 95 Pro Gly Val Pro Asp Leu Asp His Arg His Gly Val
Asp Gly Gln Arg 100 105 110 Lys Ile Thr Ile Leu Lys Pro Leu Pro Thr
Thr Ser Ala Gly Arg Lys 115 120 125 Phe Glu Leu Arg Asn Lys Val Ile
Gly Val Tyr Asp Lys Gly Lys Pro 130 135 140 Gly Thr Val Ile Glu Thr
Glu Gln Ser Ile Val Asp Lys Glu Ser Gly 145 150 155 160 Glu Val Tyr
Ser Lys Val Val Ser Ser Gly Phe Leu Val Gly Gln Gly 165 170 175 Gly
Trp Gly Gly Pro Lys Gly Pro Ser Thr Val Asn Tyr Ala Pro Pro 180 185
190 Glu Gly Arg Ala Pro Asp Ala Thr His Val Val Gln Ser Asn Ser Glu
195 200 205 Thr Ala His Leu Tyr Arg Leu Asn Gly Asp Tyr Asn Pro Leu
His Ala 210 215 220 Thr Pro Glu Pro Gly Gln Lys Met Gly Phe Gly Gly
Ile Ile Ile His 225 230 235 240 Gly Leu Phe Ser Trp Asn Ser Ala Ala
His Gly Ile Leu Arg Glu Phe 245 250 255 Gly Gly Ser Asn Pro Ala Asn
Met Lys Glu Phe Gln Ala Arg Phe Ala 260 265 270 Ser Pro Val Arg Pro
Gly Asp Lys Leu Thr Thr Glu Ile Trp Arg Met 275 280 285 Gly Asn Ile
Gln Asp Gly Tyr Glu Glu Ile Arg Phe Val Thr Lys Asn 290 295 300 Asp
Lys Gly Arg Val Val Leu Ser Asn Gly Arg Cys Leu Leu Lys Val 305 310
315 320 Thr Gly Val Lys Ser Lys Leu 325 31901PRTPenicillium
chrysogenum 31Met Ser Glu Leu Arg Phe Asp Asn Gln Thr Val Val Val
Thr Gly Ala 1 5 10 15 Gly Gly Gly Leu Gly Lys Ala Tyr Ala Leu Phe
Phe Ala Ser Arg Gly 20 25 30 Ala Asn Val Val Val Asn Asp Leu Gly
Ala Ser His Lys Gly Glu Gly 35 40 45 Lys Ser Gly Lys Ala Ala Asp
Val Val Val Glu Glu Ile Arg Ala Ala 50 55 60 Gly Gly Lys Ala Val
Ala Asn Tyr Asp Ser Val Glu Asn Gly Asp Ala 65 70 75 80 Ile Ile Glu
Thr Ala Ile Lys Ala Phe Gly Arg Ile Asp Ile Leu Leu 85 90 95 Asn
Asn Ala Gly Ile Leu Arg Asp Ile Ser Phe Lys Asn Met Lys Asp 100 105
110 Ala Asp Trp Asp Leu Ile Asn Arg Val His Thr Tyr Gly Ala Tyr Lys
115 120 125 Cys Ala Arg Ala Ala Trp Pro His Phe Arg Lys Gln Lys Phe
Gly Arg 130 135 140 Val Ile Asn Thr Ala Ser Ala Ala Gly Leu Phe Gly
Ser Phe Gly Gln 145 150 155 160 Ala Asn Tyr Ser Ala Ala Lys Leu Gly
Gln Val Gly Phe Thr Glu Thr 165 170 175 Leu Ala Lys Glu Gly Ala Lys
Tyr Asn Ile Ile Ala Asn Val Ile Ala 180 185 190 Pro Ile Ala Ala Ser
Arg Met Thr Ala Thr Val Met Pro Pro Asp Val 195 200 205 Leu Glu Asn
Leu Lys Pro Asp Trp Val Val Pro Leu Val Ala Ala Leu 210 215 220 Val
His Ser Ser Asn Thr Thr Glu Thr Gly Gly Ile Tyr Glu Val Gly 225 230
235 240 Gly Gly His Val Ala Lys Leu Arg Trp Glu Arg Ala Lys Gly Ala
Leu 245 250 255 Leu Lys Thr Asp Asp Ser Leu Thr Pro Gly Ala Ile Ala
Arg Lys Trp 260 265 270 Asn Asp Val Asn Asp Phe Ser Gln Pro Glu Tyr
Pro Thr Gly Pro Ala 275 280 285 Asp Phe Met Ala Phe Leu Glu Asp Gly
Leu Lys Thr Pro Ser Ala Gln 290 295 300 Pro Gly Gln Glu Pro Asp Phe
Lys Gly Arg Val Ala Leu Val Thr Gly 305 310 315 320 Gly Gly Ala Gly
Leu Gly Arg Ala Tyr Cys Leu Gln Phe Ala Lys Leu 325 330 335 Gly Ala
Ser Val Val Val Asn Asp Leu Val Asp Pro Glu Pro Val Val 340 345 350
Gln Glu Ile Lys Lys Leu Gly Gly Lys Ala Val Gly Asn Lys Ala Ser 355
360 365 Cys Glu Asp Gly Asp Ala Val Val Lys Ser Ala Ile Asp Ala Phe
Gly 370 375 380 Arg Ile Asp Ile Leu Val Asn Asn Ala Gly Ile Leu Arg
Asp Lys Ala 385 390 395 400 Phe Thr Asn Met Asp Asp Asn Leu Trp Asn
Ser Val Val Asn Val His 405 410 415 Leu Arg Gly Thr Tyr Lys Val Thr
Lys Ala Ala Trp Pro Tyr Phe Leu 420 425 430 Lys Gln Lys Tyr Gly Arg
Val Val Asn Thr Ala Ser Thr Ser Gly Ile 435 440 445 Tyr Gly Asn Phe
Gly Gln Ala Asn Tyr Ala Ala Ala Lys Leu Gly Ile 450 455 460 Leu Gly
Leu Ser Arg Thr Leu Ala Leu Glu Gly Ala Lys Tyr Asn Ile 465 470 475
480 Lys Val Asn Thr Ile Ala Pro Asn Ala Gly Thr Asn Met Thr Arg Thr
485 490 495 Ile Met Pro Glu Glu Met Val Gln Ala Phe Lys Pro Asp Tyr
Val Ala 500 505 510 Pro Leu Val Val Leu Leu Cys Ser Asp Met Ala Pro
Glu Pro Ser Thr 515 520 525 Lys Gly Leu Phe Glu Cys Gly Ser Gly Trp
Phe Gly Arg Thr Arg Trp 530 535 540 Gln Arg Thr Gly Gly His Gly Phe
Pro Val Asp Val Lys Leu Thr Pro 545 550 555 560 Glu Glu Val Val Arg
Asn Trp Lys Gln Ile Ile Asn Phe Asp Asp Gly 565 570 575 Arg Ala Asp
His Pro Glu Asp Gly Gln Ala Gly Ala Glu Lys Ile Met 580 585 590 Ala
Asn Met Ser Asn Arg Val His Gly Asp Thr Ser Thr Glu Asn Glu 595 600
605 Thr Leu Lys Asn Ile Lys Lys Ala Lys Ala Leu Ser Ser Glu Gly Thr
610 615 620 Pro Phe Asn Tyr Glu Asp Arg Asp Val Ile Leu Tyr Asn Leu
Ser Leu 625 630 635 640 Gly Ala Lys Arg Thr Asp Leu Pro Leu Val Tyr
Glu Asn Asn Asp Gln 645 650 655 Phe Gln Ala Leu Pro Ser Tyr Gly Val
Val Pro Trp Phe Asn Thr Ala 660 665 670 Thr Pro Trp Asn Met Asp Asp
Leu Val Lys Asp Phe Ser Pro Met Met 675 680 685 Leu Leu His Gly Glu
Gln Tyr Met Glu Val Arg Lys Phe Pro Ile Pro 690 695 700 Thr Thr Ala
Asn Thr Leu Thr Tyr Pro Lys Leu Ile Asp Val Ile Asp 705 710 715 720
Lys Gly Asn Ala Ala Ile Val Val Ala Gly Tyr Thr Thr Lys Asp Ala 725
730 735 Lys Thr Gly Glu Asp Leu Phe Tyr Asn Glu Ser Ser Val Phe Ile
Arg 740 745 750 Gly Ser Gly Gly Phe Gly Gly Ser Pro Lys Pro Thr Ala
Val Arg Pro 755 760 765 Lys Ala Ala Thr Ala Ala Tyr Lys Ala Pro Gln
Arg Gln Pro Asp Ala 770 775 780 Val Val Glu Glu Lys Thr Ser Glu Asp
Gln Ala Ala Leu Tyr Arg Leu 785 790 795 800 Asn Gly Asp Arg Asn Pro
Leu His Ile Asp Pro Glu Phe Ser Lys Val 805 810 815 Gly Gly Phe Lys
Thr Pro Ile Leu His Gly Leu Cys Ser Leu Gly Val 820 825 830 Ser Ala
Lys Ala Val Phe Ser Lys Tyr Gly Pro Tyr Lys Asn Leu Lys 835 840 845
Val Arg Phe Ala Gly Val Val Leu Pro Gly Gln Thr Leu Lys Thr Glu 850
855 860 Met Trp Lys Glu Gly Asn Thr Val Leu Phe Gln Ala Thr Val Val
Glu 865 870 875 880 Thr Gly Lys Pro Ala Ile Thr Gly Ala Gly Ala Glu
Leu Leu Glu Gly 885 890 895 Ala Lys Ala Lys Leu 900
32293PRTPenicillium chrysogenum 32Met Phe Ala Arg Gln Cys Thr Arg
Leu Ala Thr Ser Arg Thr Ser Ala 1 5 10 15 Pro Leu Thr Ser Tyr Leu
Ala Arg Val Arg Gly Tyr Ser Ser Ala Ala 20 25 30 Gly Ser Tyr Glu
His Ile Leu Thr Ser Thr Pro Lys Pro Gly Val Gly 35 40 45 Leu Ile
Thr Leu Asn Arg Pro Lys Ala Leu Asn Ala Leu Cys Ser Pro 50 55 60
Leu Phe Lys Glu Leu Asn Glu Ala Leu Ser Asn Tyr Asp Asn Asp Lys 65
70 75 80 Ser Ile Gly Ala Ile Ile Ile Thr Gly Ser Glu Lys Ala Phe
Ala Ala 85 90 95 Gly Ala Asp Ile Lys Glu Met Ala Pro Leu Ser Phe
Ser Ala Ala Tyr 100 105 110 Ser Asp Asn Phe Ile Ala Pro Trp Ser His
Leu Ala Thr Ser Ile Arg 115 120 125 Thr Pro Val Ile Ala Ala Val Ser
Gly Tyr Ala Leu Gly Gly Gly Cys 130 135 140 Glu Leu Ala Leu Met Cys
Asp Ile Leu Tyr Cys Ser Glu Asn Ala Thr 145 150 155 160 Phe Gly Gln
Pro Glu Ile Lys Leu Gly Thr Ile Pro Gly Ala Gly Gly 165 170 175 Ser
Gln Arg Leu Thr Arg Ala Ile Gly Lys Ser Lys Ala Met Glu Leu 180 185
190 Ile Leu Thr Gly Lys Asn Phe Ser Gly Lys Glu Ala Gly Glu Trp Gly
195 200 205 Val Ala Ala Lys Val Val Pro Gly Gly Lys Glu Glu Leu Leu
Glu Gln 210 215 220 Ala Tyr Lys Thr Ala Glu Thr Ile Ala Ser Tyr Ser
Arg Val Ala Val 225 230 235 240 Val Ala Gly Lys Glu Val Val Asn Lys
Ser Gln Glu Leu Ser Leu Lys 245 250 255 Glu Gly Val Glu Tyr Glu Arg
Arg Leu Phe His Ala Leu Phe Gly Ser 260 265 270 Lys Asp Gln Lys Ile
Gly Met Thr Ala Phe Ala Glu Lys Lys Lys Pro 275 280 285 Glu Trp Ser
His Glu 290 33261PRTAcinetobacter sp. 33Met Ile Pro Asp Gln Asp Asn
Phe Val Glu Ile Asp Phe Ser Ile Glu 1 5 10 15 Gln Ile Ala Ile Val
Lys Ile Asn Arg Pro Ala Ser Lys Asn Ala Leu 20 25 30 Asn Thr Glu
Val Arg Lys Gln Leu Ala Gln Ala Phe Thr Glu Leu Ser 35 40 45 Phe
Asn Asp Gln Ile Asn Ala Ile Val Leu Thr Gly Gly Glu Asp Val 50 55
60 Phe Ala Ala Gly Ala Asp Leu Lys Glu Met Ala Thr Ala Ser Ser Thr
65 70 75 80 Asp Met Leu Leu Arg His Thr Glu Arg Tyr Trp Asn Ala Ile
Ala Gln 85 90 95 Cys Pro Lys Pro Val Ile Ala Ala Val Asn Gly Tyr
Ala Leu Gly Gly 100 105 110 Gly Cys Glu Leu Ala Met His Thr Asp Ile
Ile Ile Ala Gly Lys Ser 115 120 125 Ala Thr Phe Gly Gln Pro Glu Ile
Lys Val Gly Leu Met Pro Gly Ala 130 135 140 Gly Gly Thr Gln Arg Leu
Phe Arg Ala Val Gly Lys Phe His Ala Met 145 150 155 160 Arg Met Ile
Met Thr Gly Val Met Val Pro Ala Glu Glu Ala Tyr Leu 165 170 175 Ile
Gly Leu Val Ser Gln Val Thr Glu Asp Ser Gln Thr Ile Pro Thr 180 185
190 Ala Ile Lys Met Ala Gln Ser Leu Ala Lys Met Pro Pro Ile Ala Leu
195 200 205 Gln Gln Ile Lys Glu Val Ala Leu Met Ser Glu Asp Val Pro
Leu Asn 210 215 220 Ala Gly Leu Thr Leu Glu Arg Lys Ser Phe Gln Leu
Leu Phe Ser Thr 225 230 235 240 Glu Asp Lys Asn Glu Gly Ile Asn Ala
Phe Ile Glu Lys Arg Lys Pro 245 250 255 Ser Tyr His Gly Lys 260
34136PRTAeromonas salmonicida 34Met Asn Thr Leu Pro Leu Glu Ile Gly
Gln Lys Ala Ser Leu Thr Lys 1 5 10 15 Arg Phe Gly Ala Ala Glu Val
Glu Ala Phe Ala Gly Leu Ser Glu Asp 20 25 30 Phe Asn Pro Leu His
Leu Asp Ser Ala Phe Ala Ala Thr Thr Pro Phe 35 40 45 Glu Arg Pro
Ile Val His Gly Met Leu Leu Ala Ser Leu Phe Ser Gly 50 55 60 Leu
Leu Gly Gln Gln Leu Pro Gly Lys Gly Thr Val Tyr Leu Gly Gln 65 70
75 80 Ser Leu Ser Phe Lys Gln Pro Val Phe Val Gly Asp Glu Val Thr
Ala 85 90 95 Glu Val Glu Ile Ile Ala Met Arg Ser Asp Lys Pro Ile
Ile Thr Leu 100 105 110 Ala Thr Arg Ile Leu Ala Ala Gly Gly Ala Leu
Ala Leu Ala Val Thr 115 120 125 Gly Glu Ala Val Val Lys Val Gly 130
135 35259PRTClostridium kluyveri 35Met Glu Phe Lys Asn Ile Ile Leu
Glu Lys Asp Gly Asn Val Ala Ser 1 5 10 15 Ile Thr Leu Asn Arg Pro
Lys Ala Leu Asn Ala Leu Asn Ala Ala Thr 20 25 30 Leu Lys Glu Ile
Asp Ala Ala Ile Asn Asp Ile Ala Glu Asp Asp Asn 35 40 45 Val Tyr
Ala Val Ile Ile Thr Gly Ser Gly Lys Ala Phe Val Ala Gly 50 55 60
Ala Asp Ile Ala Glu Met Lys Asp Leu Thr Ala Val Glu Gly Arg Lys 65
70 75 80 Phe Ser Val Leu Gly Asn Lys Ile Phe Arg Lys Leu Glu Asn
Leu Glu 85 90 95 Lys Pro Val Ile Ala Ala Ile Asn Gly Phe Ala Leu
Gly Gly Gly Cys 100 105 110 Glu Leu Ser Leu Ser Cys Asp Ile Arg Ile
Ala Ser Ser Lys Ala Lys 115 120 125 Phe Gly Gln Pro Glu Val Gly Leu
Gly Ile Thr Pro Gly Phe Gly Gly 130 135 140 Thr Gln Arg Leu Ala Arg
Ala Ile Gly Val Gly Met Ala Lys Glu Leu 145 150 155 160 Ile Tyr Thr
Gly Lys Val Ile Asn Ala Glu Glu Ala Leu Arg Ile Gly 165 170 175 Leu
Val Asn
Lys Val Val Glu Pro Asp Lys Leu Leu Glu Glu Ala Lys 180 185 190 Ala
Leu Val Asp Ala Ile Ile Val Asn Ala Pro Ile Ala Val Arg Met 195 200
205 Cys Lys Ala Ala Ile Asn Gln Gly Leu Gln Cys Asp Ile Asp Thr Gly
210 215 220 Val Ala Tyr Glu Ala Glu Val Phe Gly Glu Cys Phe Ala Thr
Glu Asp 225 230 235 240 Arg Val Glu Gly Met Thr Ala Phe Val Glu Lys
Arg Asp Lys Ala Phe 245 250 255 Lys Asn Lys 36257PRTClostridium
kluyveri 36Met Thr Tyr Lys Thr Leu Leu Leu Glu Lys Gln Asn Gly Ile
Thr Ile 1 5 10 15 Ile Lys Met Asn Thr Pro His Asn Leu Asn Ala Ile
Ser Gln Gln Ser 20 25 30 Val Glu Asp Leu Phe Ala Val Leu Gln Val
Ile Lys Asn Asp Asp Asn 35 40 45 Cys Arg Val Val Ile Leu Thr Gly
Glu Gly Lys Gly Phe Ile Gly Gly 50 55 60 Ala Asp Ile Lys His Met
Ala Cys Leu Asp Ala Ile Glu Gly Gly Gln 65 70 75 80 Phe Cys Phe Ala
Val Ser Lys Cys Thr Leu Glu Met Glu Lys Met Gly 85 90 95 Lys Val
Phe Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Ala Gly Leu 100 105 110
Glu Val Ala Leu Gly Cys Asp Ile Arg Ile Phe Ser Lys His Ala Lys 115
120 125 Ile Gly Phe Pro Glu Thr Gly Leu Gly Val Ile Pro Gly Ala Gly
Gly 130 135 140 Ala Gln Arg Leu Gln Arg Leu Val Gly Ile Gly Lys Ala
Ser Glu Ile 145 150 155 160 Ile Phe Thr Gly Asp Ile Ile Gly Ala Asp
Asp Ala Leu Arg Phe Gly 165 170 175 Ile Ala Asn Gln Val Thr Glu Pro
Glu Ser Leu Met Asp Thr Ala Met 180 185 190 Ser Met Ala Glu Lys Ile
Leu Thr Lys Ser Pro Val Gly Thr Arg Leu 195 200 205 Ala Lys Glu Ala
Leu Gln Lys Gly Arg Asp Thr Asp Leu Glu Lys Ala 210 215 220 Leu Glu
Tyr Asp Lys Asn Leu Phe Gly Leu Cys Phe Ser Thr Glu Asp 225 230 235
240 Lys Lys Glu Gly Met Ala Ala Phe Ile Glu Lys Arg Lys Pro Val Phe
245 250 255 Lys 37255PRTEscherichia coli 37Met Ser Glu Leu Ile Val
Ser Arg Gln Gln Arg Val Leu Leu Leu Thr 1 5 10 15 Leu Asn Arg Pro
Ala Ala Arg Asn Ala Leu Asn Asn Ala Leu Leu Met 20 25 30 Gln Leu
Val Asn Glu Leu Glu Ala Ala Ala Thr Asp Thr Ser Ile Ser 35 40 45
Val Cys Val Ile Thr Gly Asn Ala Arg Phe Phe Ala Ala Gly Ala Asp 50
55 60 Leu Asn Glu Met Ala Glu Lys Asp Leu Ala Ala Thr Leu Asn Asp
Thr 65 70 75 80 Arg Pro Gln Leu Trp Ala Arg Leu Gln Ala Phe Asn Lys
Pro Leu Ile 85 90 95 Ala Ala Val Asn Gly Tyr Ala Leu Gly Ala Gly
Cys Glu Leu Ala Leu 100 105 110 Leu Cys Asp Val Val Val Ala Gly Glu
Asn Ala Arg Phe Gly Leu Pro 115 120 125 Glu Ile Thr Leu Gly Ile Met
Pro Gly Ala Gly Gly Thr Gln Arg Leu 130 135 140 Ile Arg Ser Val Gly
Lys Ser Leu Ala Ser Lys Met Val Leu Ser Gly 145 150 155 160 Glu Ser
Ile Thr Ala Gln Gln Ala Gln Gln Ala Gly Leu Val Ser Asp 165 170 175
Val Phe Pro Ser Asp Leu Thr Leu Glu Tyr Ala Leu Gln Leu Ala Ser 180
185 190 Lys Met Ala Arg His Ser Pro Leu Ala Leu Gln Ala Ala Lys Gln
Ala 195 200 205 Leu Arg Gln Ser Gln Glu Val Ala Leu Gln Ala Gly Leu
Ala Gln Glu 210 215 220 Arg Gln Leu Phe Thr Leu Leu Ala Ala Thr Glu
Asp Arg His Glu Gly 225 230 235 240 Ile Ser Ala Phe Leu Gln Lys Arg
Thr Pro Asp Phe Lys Gly Arg 245 250 255 38257PRTPseudomonas putida
38Met Pro Arg Tyr Leu Asp Val Gln Ala Pro Glu Asn Gly Val Gln Leu 1
5 10 15 Ile Thr Leu Gln Arg Pro Glu Ala Leu Asn Ala Leu Cys Thr Glu
Leu 20 25 30 Leu Ala Glu Leu Ala Thr Ala Leu Asp Ala Ala Ala Arg
Asp Asp Gln 35 40 45 Ile Gly Val Val Val Leu Thr Gly Ser Arg Lys
Ala Phe Ala Ala Gly 50 55 60 Ala Asp Ile Arg Glu Met Ala Glu Arg
Asp Leu Val Gly Ile Leu Asn 65 70 75 80 Asp Pro Arg Val Ala His Trp
Gln Arg Ile Ala Ala Phe Ala Lys Pro 85 90 95 Leu Ile Ala Ala Val
Asn Gly Tyr Ala Leu Gly Gly Gly Cys Glu Leu 100 105 110 Val Met Cys
Ala Asp Ile Val Ile Ala Gly Ser Asp Ala Arg Phe Gly 115 120 125 Gln
Pro Glu Ile Asn Leu Gly Ile Ile Pro Gly Ala Gly Gly Thr Gln 130 135
140 Arg Leu Leu Arg Ala Val Gly Lys Pro Leu Ala Met Gln Met Val Leu
145 150 155 160 Thr Gly Glu Ala Ile Thr Ala Arg His Ala Gln Gln Ala
Gly Leu Val 165 170 175 Ser Glu Ile Thr Gln Pro Glu Phe Thr Val Glu
Arg Ala Met Gln Ile 180 185 190 Ala Arg Asn Ile Ala Ala Lys Ala Pro
Leu Ala Val Arg Leu Ala Lys 195 200 205 Glu Ala Leu Leu Lys Ala Gly
Asp Thr Asp Leu Ala Ser Gly Leu Arg 210 215 220 Phe Glu Arg His Ala
Phe Thr Leu Leu Ala Gly Thr Ala Asp Arg Asp 225 230 235 240 Glu Gly
Ile Gln Ala Phe Gln Glu Lys Arg Pro Ala Arg Phe Gln Gly 245 250 255
Arg 39263PRTPseudomonas putida 39Met Thr Phe Gln His Ile Leu Phe
Ser Ile Glu Asp Gly Val Ala Phe 1 5 10 15 Leu Ser Leu Asn Arg Pro
Glu Gln Leu Asn Ser Phe Asn Ala Ala Met 20 25 30 His Leu Glu Val
Arg Glu Ala Leu Lys Gln Val Arg Gln Ser Ser Asp 35 40 45 Ala Arg
Val Leu Leu Leu Thr Ala Glu Gly Arg Gly Phe Cys Ala Gly 50 55 60
Gln Asp Leu Ser Asp Arg Asn Val Ala Pro Asp Ala Glu Val Pro Asp 65
70 75 80 Leu Gly Glu Ser Ile Asp Lys Phe Tyr Asn Pro Leu Val Arg
Thr Leu 85 90 95 Arg Asp Leu Pro Leu Pro Val Ile Cys Ala Val Asn
Gly Val Ala Ala 100 105 110 Gly Ala Gly Ala Asn Ile Pro Leu Ala Cys
Asp Leu Val Leu Ala Gly 115 120 125 Arg Ser Ala Ser Phe Ile Gln Ala
Phe Cys Lys Ile Gly Leu Val Pro 130 135 140 Asp Ser Gly Gly Thr Trp
Leu Leu Pro Arg Leu Val Gly Met Ala Arg 145 150 155 160 Ala Lys Ala
Leu Ala Met Leu Gly Glu Arg Leu Gly Ala Glu Gln Ala 165 170 175 Gln
Gln Trp Gly Leu Ile His Arg Val Val Asp Asp Ala Ala Leu Arg 180 185
190 Asp Glu Ala Leu Thr Leu Ala Arg Gln Leu Ala Ser Gln Pro Thr Tyr
195 200 205 Gly Leu Ala Leu Ile Lys Arg Ser Leu Asn Ala Ser Phe Asp
Asn Gly 210 215 220 Phe Asp Glu Gln Leu Glu Leu Glu Arg Asp Leu Gln
Arg Leu Ala Gly 225 230 235 240 Arg Ser Glu Asp Tyr Arg Glu Gly Val
Ser Ala Phe Met Asn Lys Arg 245 250 255 Thr Pro Ala Phe Lys Gly Arg
260 40699PRTRhodopseudomonas palustris 40Met Ser Glu Val Val Thr
Arg Ala Thr Gln Asp Gln Val Ala Ile Val 1 5 10 15 Thr Val Asp Ser
Pro Pro Val Asn Ala Leu Ser Ala Ala Val Arg Arg 20 25 30 Gly Ile
Leu Glu Asn Val Asn Ala Ala Val Ala Asp Pro Ala Val Gln 35 40 45
Ala Ile Val Leu Val Cys Ala Gly Arg Thr Phe Ile Ala Gly Ala Asp 50
55 60 Ile Thr Glu Phe Gly Lys Pro Pro Gln Pro Pro Ala Leu Asn Asp
Val 65 70 75 80 Ile Ala Ala Leu Glu Asn Ser Pro Lys Pro Thr Ile Ala
Ala Ile His 85 90 95 Gly Thr Ala Leu Gly Gly Gly Leu Glu Val Ala
Leu Gly Cys His Phe 100 105 110 Arg Val Ala Val Lys Glu Ala Lys Leu
Gly Leu Pro Glu Val Lys Leu 115 120 125 Gly Leu Leu Pro Gly Ala Gly
Gly Thr Gln Arg Leu Pro Arg Ala Val 130 135 140 Gly Pro Glu Leu Ala
Val Gln Met Ile Val Gly Gly Ser Pro Ile Gly 145 150 155 160 Ala Ala
Glu Ala Leu Lys His Gly Leu Val Glu Glu Val Val Glu Asn 165 170 175
Leu Val Ala Gly Ala Val Ala Phe Ala Lys Lys Val Leu Ala Glu Lys 180
185 190 Arg Pro Leu Arg Arg Leu Arg Asp Asp Asp Ser Lys Leu Ala Ala
Ala 195 200 205 Lys Ala Asp Arg Ser Ile Phe Thr Asn Ala Val Ala Ala
Met Thr Lys 210 215 220 Lys Ala Arg Gly Leu Glu Ala Pro Phe Ala Cys
Ala Asp Ala Ile Gly 225 230 235 240 Ala Ala Ile Asp Leu Pro Phe Glu
Glu Gly Leu Lys Lys Glu Arg Glu 245 250 255 Gly Phe Met Lys Leu Val
Val Ser Asp Gln Ser Lys Ala Gln Arg Tyr 260 265 270 Ala Phe Phe Ala
Glu Arg Glu Ala Ala Lys Val Asp Gly Val Pro Asp 275 280 285 Gly Thr
Lys Pro Arg Pro Val Ser Arg Val Ala Ile Ile Gly Ala Gly 290 295 300
Thr Met Gly Gly Gly Ile Ala Met Ser Phe Ala Asn Ala Gly Ile Pro 305
310 315 320 Val Thr Leu Ile Glu Thr Gly Glu Glu Gln Leu Lys Arg Gly
Leu Gly 325 330 335 Ile Met Gln Lys Asn Trp Glu Ala Thr Ala Ala Arg
Gly Gly Leu Pro 340 345 350 Pro Asp Ala Pro Ala Lys Arg Met Ala Leu
Ile Thr Gly Leu Val Gly 355 360 365 Leu Glu Asn Val Lys Asp Ala Asp
Leu Ile Ile Glu Ala Val Phe Glu 370 375 380 Thr Met Ala Val Lys Lys
Glu Val Phe Thr Ala Val Asp Ala His Ala 385 390 395 400 Lys Pro Gly
Ala Val Leu Ala Ser Asn Thr Ser Tyr Leu Ser Ile Asp 405 410 415 Glu
Ile Ala Ala Thr Thr Lys Arg Pro Gln Asp Val Leu Gly Met His 420 425
430 Phe Phe Ser Pro Ala Asn Val Met Lys Leu Cys Glu Ile Val Arg Gly
435 440 445 Ala Lys Thr Ala Pro Asp Ala Leu Leu Thr Ala Val Ser Ile
Ala Lys 450 455 460 Lys Ile Ala Lys Val Pro Val Val Val Gly Val Cys
Asp Gly Phe Val 465 470 475 480 Gly Asn Arg Met Leu Ala Ala Arg Ser
Lys Gln Ser Glu Lys Leu Leu 485 490 495 Phe Glu Gly Ala Leu Pro Gln
Gln Val Asp Ala Val Val Thr Lys Phe 500 505 510 Gly Met Pro Met Gly
Pro Phe Ala Met Gly Asp Leu Ala Gly Leu Asp 515 520 525 Ile Gly Trp
Arg Ser Arg Lys Asp Arg Gly Ile Lys Ser Glu Ile Ala 530 535 540 Asp
Ala Leu Cys Glu Ala Gly Arg Phe Gly Gln Lys Thr Gly Lys Gly 545 550
555 560 Tyr Tyr Lys Tyr Glu Gln Gly Ser Arg Ala Pro Met Pro Asp Pro
Glu 565 570 575 Val Glu Thr Leu Ile Asn Asp Thr Leu Ala Lys Leu Gly
Leu Lys Arg 580 585 590 Arg Asp Ile Thr Asp Glu Glu Ile Leu Glu Arg
Met Val Tyr Pro Met 595 600 605 Ile Asn Glu Gly Ala Arg Ile Leu Glu
Glu Lys Ile Ala Ala Arg Pro 610 615 620 Ser Asp Ile Asp Val Val Trp
Leu Tyr Gly Tyr Gly Trp Pro Ile Tyr 625 630 635 640 Arg Gly Gly Pro
Met His Tyr Ala Asp Ser Val Gly Leu Lys His Ile 645 650 655 Ala Glu
Arg Leu Ser Ala Tyr Ala Lys Ala Thr Asn Asp Pro Ser Leu 660 665 670
Glu Pro Ala Pro Leu Leu Ala Arg Leu Ala Ala Glu Gly Lys Thr Phe 675
680 685 Ala Ser Leu Thr Gln Pro Ser Lys Ala Ala Ala 690 695
41242PRTRhodococcus sp. 41Met Asn Thr Leu Lys Ile Glu Asp Arg Asp
Asp Arg Met Val Val Thr 1 5 10 15 Leu His Arg Pro Ala Gln Arg Asn
Ala Ile Asn Ala Glu Met Ile Gly 20 25 30 Glu Leu His Gln Val Cys
Ala Ser Leu Glu Ala Thr Pro Lys Pro Met 35 40 45 Leu Leu Thr Gly
Glu Gly Asp His Phe Ala Gly Gly Ala Asp Ile Ala 50 55 60 Glu Leu
Arg Glu Arg Gly Arg Asp Glu Ala Phe Ala Gly Ile Asn Arg 65 70 75 80
Asn Leu Phe Asp Arg Ile Ala Lys Leu Pro Met Pro Thr Val Ala Ala 85
90 95 Val Ser Gly Tyr Ala Leu Gly Gly Gly Ala Glu Leu Ser Tyr Ala
Cys 100 105 110 Asp Ile Arg Ile Ala Thr Glu Thr Ala Val Phe Gly Asn
Pro Glu Pro 115 120 125 Gly Leu Gly Ile Met Ala Ala Ala Gly Ala Ser
Tyr Arg Leu Pro Glu 130 135 140 Leu Val Gly Thr Ser Val Ala Lys Gln
Val Leu Leu Gly Gly Arg Asn 145 150 155 160 Leu Asp Ala Gln Asp Ala
Leu Arg Ser Gly Leu Val Met Ser Val Val 165 170 175 Ala Pro Gly Glu
His Ile Asp Ala Ala His Lys Val Ile Asp Arg Ile 180 185 190 Thr Arg
Ser Ala Pro Leu Ala Leu Lys Leu Thr Lys Met Ile Val Asp 195 200 205
Ala Pro Gly Ser His Pro Phe Ala Asp Asp Ile Ala Gln Ala Val Leu 210
215 220 Phe Glu Ser Arg Asp Lys His Asp Arg Met Thr Ala Phe Leu Glu
Lys 225 230 235 240 Lys Lys 42689PRTPenicillium chrysogenum 42Met
Pro Asp Phe Thr Asp Asn Leu Arg Pro Ser Gln Pro Asp Gly Pro 1 5 10
15 Thr Thr Leu Ala Arg Glu Arg Gln Lys Ser Asn Ile Ala Thr Glu Glu
20 25 30 Leu Gly Gln His Leu Leu Gly Ser Asp Gly Phe Leu Val Arg
Gln Ala 35 40 45 Arg Ile Leu Pro Ile Ile Gln Gln Glu Pro Leu Phe
Ser Lys Asp Gln 50 55 60 Gln Gln Asn Leu Ser Arg Pro Glu Arg Phe
Lys Leu Gly Val Ala Arg 65 70 75 80 Ala Lys Leu Leu Arg Gln Met Lys
Asp Thr His Lys Trp Ser His Leu 85 90 95 Glu Tyr Gln Met Ala Glu
Tyr Leu Val Asp Asp Val Ser Pro Tyr Phe 100 105 110 Leu His Met Glu
Met Phe Ile Thr Thr Ile Arg Glu Gln Ala Ser Glu 115 120 125 Glu Gln
Gln Ala His Trp Leu Pro Leu Ile Glu Leu Trp Lys Ile Ile 130 135 140
Gly Ala Tyr Ala Gln Thr Glu Leu Gly His Gly Ser Asn Val Arg Gly 145
150 155 160 Leu Glu Leu Glu Ala Arg Trp Asp Asn Arg Thr Lys Glu Phe
Val Leu 165 170 175 His Ser Pro Thr Leu Thr Ala Ser Lys Trp Trp Asn
Gly Ser Leu Gly 180 185 190 Arg Leu Ala Asn His Ala Ile Val Val Ala
Gln Leu Leu Leu Pro Asp 195 200 205 Pro Ser Ser Pro Asp Gln Tyr Val
Ser His Gly Pro His Pro Phe Ile 210 215 220 Val Gln Val Arg
Asp Met Lys Thr His Gln Pro Leu Asn Gly Ile Val 225 230 235 240 Val
Gly Asp Ile Gly Pro Lys Tyr Gly Tyr Ile Thr Met Asp Asn Ala 245 250
255 Tyr Met Leu Phe Asp Gln Phe Arg Ile Pro His Ser Ala Met Leu Ser
260 265 270 Arg Tyr Ser Lys Val Asp Leu Asn Thr Gly Ile Tyr Thr Lys
Pro Glu 275 280 285 Lys Pro Ala Leu Val Tyr Gly Ser Leu Thr Tyr Val
Arg Ser Asn Met 290 295 300 Val His Arg Ala Arg Leu Val Leu Ala Arg
Ala Val Thr Val Ala Val 305 310 315 320 Arg Tyr Ser Ser Val Arg Arg
Gln Phe Gln Asp Arg Asp Gly Asp Lys 325 330 335 Thr Gly Pro Glu Met
Ser Val Leu Asp Tyr Pro Thr Val Gln Ile Arg 340 345 350 Ile Leu Pro
Leu Leu Ala Thr Thr Phe Ala Leu His Tyr Thr Gly Leu 355 360 365 Ala
Met Gln Thr Val Tyr Lys Asn Ala Arg Gln Asp Ile Glu Glu Gly 370 375
380 Asn Phe Asn Ser Leu Ala His Met His Ser Met Ser Ser Gly Leu Lys
385 390 395 400 Ser Leu Cys Thr Ile Phe Ala Ala Asp Gly Ile Glu Thr
Cys Arg Arg 405 410 415 Ala Met Gly Gly His Gly Phe Gly Gly Gly Ser
Gly Leu Ile Gln Val 420 425 430 Asn Asn Asp Tyr Leu Ser Lys Pro Thr
Val Glu Gly Asp Asn Trp Met 435 440 445 Ile Thr Gln Gln Val Ala Ala
Tyr Val Ile Lys Lys Met Thr Ala Ala 450 455 460 Val Gly Ser Pro Asp
Thr Pro Gly Ile Asp Glu Thr Asp Ala Arg Phe 465 470 475 480 Lys Glu
Phe Ile Arg Asn Lys Arg Arg Pro Glu Ser Glu Lys Arg Thr 485 490 495
Tyr Asp Ile Leu Asn Ser Asp Leu Asp Ile Val Lys Ser Phe Glu Leu 500
505 510 Arg Ala Thr Ala Met Ala Ser Ser Thr Lys Leu Ile Arg Val Ile
Lys 515 520 525 Lys Arg Asn Trp Asn Ser Leu Leu Ile Gln Leu His Lys
Leu Ser Arg 530 535 540 Ala Gln Ser Glu Ser Ile Ile Val Ala Thr Phe
Phe Asp Ala Leu Ser 545 550 555 560 Asn Asp Lys Thr Leu Ser Ala Pro
Thr Lys Asn Val Leu Trp Asp Cys 565 570 575 Tyr Arg Leu Phe Ala Leu
Tyr Ser Met Glu Asn Glu Ser Phe Glu Phe 580 585 590 Leu Arg Thr Asn
Ala Val Ser Gln Thr Asp Leu Asp Ser Leu Ala Ser 595 600 605 Arg Val
Gln Asp Leu Met Ala Arg Ile Arg Pro His Ala Val Thr Leu 610 615 620
Val Asp Ser Trp Met Ile Pro Asp Tyr Leu Leu Asp Ser Ala Leu Gly 625
630 635 640 Arg Tyr Asp Gly Arg Val Tyr Glu Asp Leu Phe Asn Arg Ala
His Arg 645 650 655 Leu Asn Pro Leu Asn Arg Ile Thr Phe Asn Pro Asn
Tyr Trp Glu Asp 660 665 670 Glu Ile Val Lys Gly Ser Gly Asp Asn Gly
Arg Gly Ile Leu Ser Lys 675 680 685 Leu 43425PRTPenicillium
chrysogenum 43Met Ser Val Ser Asn Val Pro Phe Ala Asp Pro Leu Trp
Leu Asn Arg 1 5 10 15 Lys His Ser Pro Tyr Tyr Lys Asp Ser His Arg
Lys Leu Gln Lys Glu 20 25 30 Val Arg Gln Tyr Val Asp Glu His Ile
Ser Pro Phe Cys Glu Glu Trp 35 40 45 Glu Lys Gln Gly Phe Val Pro
Pro Glu Ala Gln Lys Arg His Ala Glu 50 55 60 Leu Gly Tyr Thr Ala
Val Ala Ser Phe Pro Leu Ala Ala Asp Tyr Leu 65 70 75 80 Asp Gly Gln
Arg Leu Pro Gly Asp Ile Asn Pro Tyr Glu Trp Asp Gly 85 90 95 Phe
His Asp Ile Val Val Ile Asp Glu Leu Ala Arg Cys Gly Tyr Leu 100 105
110 Gly Ile Val Trp Ala Leu Gly Cys Gly Asn Ser Ile Gly Gly Pro Pro
115 120 125 Ile Ile Asn Phe Gly Asn Glu Glu Gln Lys Arg Arg Phe Leu
Pro Asp 130 135 140 Met Leu Lys Gly Lys Ile Arg Phe Cys Leu Gly Val
Thr Glu Pro Asp 145 150 155 160 Ala Gly Ser Asp Val Ala Gly Ile Thr
Thr Val Ala Glu Arg Lys Gly 165 170 175 Asp Ala Tyr Ile Val Asn Gly
Ala Lys Lys Trp Ile Thr Asn Gly Ile 180 185 190 Phe Ala Asp Phe Cys
Thr Ala Ala Val Arg Thr Gly Gly Ser Gly Thr 195 200 205 His Gly Ile
Ser Ala Leu Val Ile Pro Met Lys Ala Pro Gly Val Ile 210 215 220 Cys
Arg Lys Ile Glu Asn Ser Gly Val His Ala Ser Gly Ser Thr Tyr 225 230
235 240 Ile Glu Phe Asp Gln Val Glu Val Pro Val Asp Asn Leu Leu Gly
Glu 245 250 255 Glu Asn Lys Gly Phe Pro Val Ile Met Asn Asn Phe Asn
His Glu Arg 260 265 270 Leu Trp Leu Ala Cys Thr Ser Leu Arg Met Ala
Arg Val Cys Ala Glu 275 280 285 Asp Ala Tyr Gln His Ala Ile Thr Arg
Glu Thr Phe Gly Lys Arg Leu 290 295 300 Ile Glu Asn Gln Ile Ile Arg
Ser Lys Phe Ser Ala Met Ala Arg Ser 305 310 315 320 Leu Asp Ser Asn
Tyr Ala Trp Met Glu Gln Leu Val Tyr Ile Ala Glu 325 330 335 Ile Ala
Lys Lys Glu Gly Thr Asp Ala Gly Thr Gly Gly Leu Phe Ala 340 345 350
Asn Leu Lys Val Leu Ala Gly Gln Thr Leu Glu Lys Val Asn Arg Glu 355
360 365 Ser Gln Gln Val Met Gly Gly Leu Gly Tyr Ser Lys Asn Gly Arg
Gly 370 375 380 Ser Arg Ile Glu Gln Val Ser Arg Asp Val Arg Val Met
Val Val Gly 385 390 395 400 Gly Gly Ser Glu Glu Ile Leu Ser Glu Leu
Ala Val Asn Gln Glu Ile 405 410 415 Lys Ala Met Lys Lys Gln Ser Lys
Leu 420 425 44605PRTPenicillium chrysogenum 44Met Ala Ala Gln Ser
Arg Val Pro Ala Thr Ala Glu Ser Gly Thr Phe 1 5 10 15 Thr Gln Leu
Gly Pro Leu Pro Asn Thr Tyr Thr Ser Asp Ile Ser Leu 20 25 30 Gln
Arg Met Leu Gly Trp Tyr Leu Pro Ala Gln Thr Leu Lys Leu Ile 35 40
45 Glu Pro His Leu Ala Gln Leu Gly Glu Glu Ala Val Ser Pro Gln Val
50 55 60 Phe Ala Trp Asn Ala Asp Ala Glu Thr Asn Leu Pro Tyr Val
Lys Lys 65 70 75 80 Tyr Asn Val Trp Gly Gln Arg Tyr Ala Tyr Asp Arg
Leu Val Thr Thr 85 90 95 Asp Gly Trp Lys Gln Leu Gly Lys Trp Gly
Ala Lys His Gly Val Val 100 105 110 Ser Leu Gly Tyr Asp His Thr Tyr
Gly Val Tyr Arg Arg Thr Ala Gln 115 120 125 Tyr Ala Ala Val Tyr Leu
Tyr Ala Pro Ser Ser Ala Met Tyr Arg Cys 130 135 140 Pro Met Ser Met
Ser Asp Gly Ala Ala Leu Thr Ser Gly Gln Trp Met 145 150 155 160 Thr
Glu Arg Ala Gly Gly Ser Asp Val Gln Asn Thr Glu Thr Trp Ala 165 170
175 Thr Tyr Ala Pro Leu Pro Gln Glu Ser Lys Thr Ser Asp Val Leu Ala
180 185 190 Glu Gly Asp Tyr Leu Ile Ser Gly Phe Lys Phe Phe Ser Ser
Ala Thr 195 200 205 Asp Ala Asn Val Ala Phe Leu Leu Ala Lys Thr Asp
Ser Gly Lys Leu 210 215 220 Ser Thr Phe Ile Ala Pro Leu Arg Lys Thr
Ser Ile Gly Ala Asp Gly 225 230 235 240 Lys Pro Glu Glu Thr Ser Asn
Gly Val Arg Ile His Arg Phe Lys Asn 245 250 255 Lys Leu Gly Thr Lys
Glu Leu Pro Thr Ala Glu Leu Glu Leu Lys Gly 260 265 270 Met Arg Ala
His Leu Val Gly Glu Leu Asp Gln Gly Ile Val Thr Ile 275 280 285 Ala
Pro Leu Leu Asn Thr Thr Arg Ile Gln Thr Leu Leu Gly Thr Leu 290 295
300 Ser Thr Trp Arg Arg Ala Ile Ser Ile Thr Lys Asn Phe Ala Lys Ser
305 310 315 320 Arg Thr Thr Val Gly Glu Pro Leu Trp Leu Ile Pro Met
His Leu Arg 325 330 335 Leu Leu Ala Asp Val Glu Val Lys His Arg Gly
Ala Ile Asn Leu Ala 340 345 350 Phe Phe Thr Ile Ala Val Met Gly Leu
Ile Glu Asn Pro Ser Ser Pro 355 360 365 Ala Arg His Ala His Met Pro
Arg Asp Pro Thr Glu Ala Lys Val Val 370 375 380 Phe Arg Val Leu Thr
Ala Thr Ser Lys Gly Val Val Ser Lys Met Ser 385 390 395 400 Met Val
Gly Val Gln Glu Cys Gln Glu Ala Ile Gly Gly Val Gly Tyr 405 410 415
Ile Asp Glu Pro Asp Glu Pro Glu Phe Asn Ile Ser Arg Leu Leu Arg 420
425 430 Ser Ala Ala Val Tyr Pro Ile Trp Glu Gly Thr Thr Asn Val Leu
Ala 435 440 445 Ser Glu Leu Val Arg Phe Leu Met Lys Gly Asp Asn Leu
Ser Ile Leu 450 455 460 Ser Gly Trp Leu Gly His Val Val Ser Leu Ile
Arg Thr Pro Ser Leu 465 470 475 480 Ala Gly Ala Leu Lys Gln Ala Met
Ala Ser Tyr Leu Ser Arg Val Thr 485 490 495 Ser Thr Arg Pro Gln Ala
Ala Leu Leu Ala Asp Ala Arg Arg Val Met 500 505 510 Phe Thr Phe Ala
Trp Ile Leu Ser Gly Ala Leu Leu Thr Leu Asp Ala 515 520 525 Glu Arg
Asp Glu Asp Glu Val Ala Met Glu Ile Ala Arg Arg Trp Val 530 535 540
Leu Leu Gly Glu Gly Gly Val Gly Glu Phe Val Tyr Arg Asp Ile Ala 545
550 555 560 Lys Pro Tyr Gln Cys Phe Asn Leu Arg Ser Gly Arg Asp Glu
His Thr 565 570 575 Arg Leu Asp Cys Lys Ile Ala Trp Gly Val Glu Leu
Pro Gly Lys Ile 580 585 590 Val Phe Gly His Arg Ser Leu Ser Glu Ser
Ser Lys Leu 595 600 605 45425PRTPenicillium chrysogenum 45Met Met
Asn Arg Ser Leu Leu Arg Ala Ala Ala Arg Ser Ile Gln Ala 1 5 10 15
Gly Pro Thr Ser Val Ala Gly Arg Arg Tyr Ala Ser Ser Ala Val Phe 20
25 30 Asn Trp Glu Asp Pro Leu Ala Ala Ala Glu Leu Phe Thr Asp Glu
Glu 35 40 45 Leu Ala Ile Gln Asp Thr Ala Arg Gln Tyr Cys Gln Asp
Lys Leu Ala 50 55 60 Pro Arg Val Leu Glu Ala Tyr Arg Asn Glu Asp
Tyr Asp Arg Arg Ile 65 70 75 80 Leu Glu Glu Met Gly Asp Leu Gly Leu
Leu Gly Ala Ser Ile Glu Gly 85 90 95 Tyr Gly Cys Ala Gly Val Ser
Thr Val Ala Ser Gly Leu Ile Thr Lys 100 105 110 Glu Val Glu Arg Val
Asp Ser Gly Tyr Arg Ser Gly Met Ser Val Gln 115 120 125 Ser Ser Leu
Ala Met Thr Gly Ile Tyr Glu Phe Gly Thr Glu Glu Gln 130 135 140 Lys
Gln Arg Phe Leu Pro Ser Leu Ala Lys Gly Thr Leu Ala Gly Cys 145 150
155 160 Phe Gly Leu Thr Glu Pro Asn His Gly Ser Asp Pro Gly Ser Met
Glu 165 170 175 Thr Val Ala Arg Glu His Pro Thr Gln Lys Gly Met Tyr
Leu Leu Ser 180 185 190 Gly Ser Lys Thr Trp Ile Thr Asn Ser Pro Ile
Ala Asp Val Ala Leu 195 200 205 Val Trp Ala Lys Leu Glu Ser Thr Gly
Lys Ile Arg Gly Phe Ile Val 210 215 220 Glu Arg Glu Arg Ala Thr Pro
Gly Ser Tyr Glu Thr Pro Ala Ile Lys 225 230 235 240 Asn Lys Ser Ala
Leu Arg Ala Ser Ile Thr Gly Met Ile Gln Met Asp 245 250 255 Asn Cys
Pro Val Pro Ala Glu Asn Met Leu Pro Glu Val Glu Gly Leu 260 265 270
Lys Gly Pro Phe Thr Cys Leu Asn Ser Ala Arg Leu Gly Ile Ala Phe 275
280 285 Gly Ala Met Gly Ala Leu Glu Asp Cys Leu Ala Arg Ala Arg Glu
Tyr 290 295 300 Ser Leu Glu Arg Lys Gln Phe Lys Gly Asn Pro Leu Ala
Lys Tyr Gln 305 310 315 320 Leu Ile Gln Met Lys Leu Ala Asn Ala Ala
Thr Asp Ala Ala Tyr Gly 325 330 335 Thr Leu Ala Ala Val Gln Val Ala
Arg Leu Lys Asp Ala Gly Lys Ala 340 345 350 Thr Pro Glu Met Ile Ser
Met Ile Lys Arg Gln Asn Cys Asp Arg Ala 355 360 365 Leu Ala Asn Ser
Arg Ile Leu Gln Glu Val Phe Gly Gly Asn Ala Ala 370 375 380 Ser Asp
Glu Tyr His Ile Ala Arg His Val Ala Asn Leu Phe Val Val 385 390 395
400 Gln Thr Tyr Glu Gly Gln Ser Asp Ile His Ala Leu Ile Leu Gly Arg
405 410 415 Ala Ile Thr Gly Lys Gln Ala Phe Val 420 425
46633PRTPenicillium chrysogenum 46Met Ser Ser Ser Gln Pro Ala Thr
Ala Asp Ser Gly Tyr Ile Thr Asp 1 5 10 15 Pro Gly Pro Leu Glu Asn
Thr Tyr Thr Ser Asp Pro Ser Leu Gln Arg 20 25 30 Ala Leu Ala Trp
Tyr Leu Pro Ser Ala Thr Leu Gln Ser Val Gln Pro 35 40 45 His Leu
Thr Gln Phe Gly Ala Glu Ala Ile Ser Glu Gln Val Arg Glu 50 55 60
Trp Ser Ala Asp Ala Glu Arg Asn Val Pro Tyr Val Lys Ser His Asn 65
70 75 80 Val Trp Gly Lys Arg Tyr Asp Tyr Asp Arg Leu Val Thr Thr
Glu Gly 85 90 95 Trp Lys Gln Leu Gly Lys Trp Gly Ala Arg Asn Arg
Ile Val Ser Ala 100 105 110 Gly Tyr Asp Lys Ser Leu Gly Val Asp Arg
Arg Thr Val Gln Tyr Ala 115 120 125 Leu Asn Tyr Leu Tyr Ser Pro Ser
Ser Gly Leu Tyr Ser Cys Pro Ile 130 135 140 Ser Met Thr Asp Gly Ala
Ala Phe Ile Leu Ser Ser Arg Ile Asn Lys 145 150 155 160 Leu Pro Ser
Thr His Pro Phe His Thr Ala Phe Gln Gly Leu Ile Ser 165 170 175 Glu
Lys Asp Asp His Trp Thr Ser Gly Gln Trp Met Thr Glu Arg Ala 180 185
190 Gly Gly Ser Asp Val Gln Asn Thr Glu Thr Trp Ala Thr Tyr Ser Pro
195 200 205 Leu Ala Ser Ser Ser Gly Ser Glu Pro Leu Gly Asp Gly Asp
Tyr Leu 210 215 220 Ile Ser Gly Phe Lys Phe Phe Ser Ser Ala Thr Asp
Ala Asn Leu Ala 225 230 235 240 Leu Leu Leu Ala Lys Thr Pro Ser Gly
Lys Leu Ser Thr Phe Leu Ala 245 250 255 Pro Leu Arg Arg Thr Val Val
Gly Gly Asp Gly Val Ser Arg Val Val 260 265 270 Ser Asn Gly Val Arg
Ile His Arg Leu Lys Asn Lys Leu Gly Thr Lys 275 280 285 Glu Leu Pro
Thr Ala Glu Leu Glu Leu Lys Asp Met Arg Ala His Leu 290 295 300 Ile
Gly Glu Ile Asp Gln Gly Ile Val Thr Ile Ala Pro Leu Leu Asn 305 310
315 320 Val Thr Arg Leu His Thr Phe Val Gly Ser Leu Ala Gly Trp Arg
Arg 325 330 335 Ala Ile Ser Ile Thr Lys Ser Phe Ala Lys Ala Arg Thr
Thr Val Gly 340 345 350 Glu Pro Leu Trp Leu Ile Pro Met His Leu Arg
Leu Leu Ala Asp Met 355 360 365 Glu Val Lys His Arg Gly Ala
Met Asn Leu Ala Trp Phe Thr Val Ala 370 375 380 Leu Phe Gly Val Val
Glu Asp Arg Thr Pro Ser Ser Asn Lys Ile Ala 385 390 395 400 His Leu
Pro Gln Pro Gly Lys Glu Ala Glu Val Val Phe Arg Thr Leu 405 410 415
Thr Ala Thr Ala Lys Ala Val Ile Ser Lys Met Ala Thr Ala Gly Ile 420
425 430 Gln Glu Cys Gln Glu Ser Met Gly Gly Val Gly Tyr Met Asp Glu
Ala 435 440 445 Asp Glu Pro Glu Phe Asn Ile Ser Arg Ile Leu Arg Asn
Asn Ala Val 450 455 460 Asn Ser Ile Trp Glu Gly Thr Thr Asn Val Leu
Ala Ser Glu Phe Val 465 470 475 480 Arg Phe Leu Ile Lys Lys Asp Asn
Leu Lys Ile Phe Gly Thr Trp Leu 485 490 495 Asp Arg Thr Leu Ala Leu
Ile Gln Ser Val Asp Leu Arg Asn Ala Leu 500 505 510 Thr Ala Ala Trp
Leu Ala Leu His Ala Arg Phe Met Thr Gln Asp Pro 515 520 525 Ala Thr
Thr Val Ala Asp Gly Arg Arg Phe Met Phe Thr Val Ala Trp 530 535 540
Ile Leu Ser Gly Ala Leu Leu Ala Leu Asp Thr Glu Arg Asp Asn Asp 545
550 555 560 Pro Val Thr Ala Glu Ile Ala Arg Arg Trp Ile Leu Ser Ala
Glu Gly 565 570 575 Gly Val Gly Glu Gln Val Phe His Asp Ile Val Thr
Val Ser Gly Thr 580 585 590 Ala Ser Ala Thr Ser Gly Gly Glu Glu His
Leu Gln Trp Asp Cys Arg 595 600 605 Ile Ala Trp Gly Val Asp Leu Pro
Ala Asn Arg Ala Ser Gly His Arg 610 615 620 Ser Leu Gln Lys Ala Gly
Ser Lys Leu 625 630 47695PRTPenicillium chrysogenum 47Met Pro Ser
Pro Pro Pro Asp Trp Val Lys Ala Leu Lys Pro Ser Gly 1 5 10 15 Pro
Gln Gly Ser Glu Leu Leu His Gln Glu Arg Ala Gln Ser Asn Val 20 25
30 Asp Val Glu Arg Leu Ser Glu Leu Leu His Thr Lys Glu Thr Leu Glu
35 40 45 Arg Arg Ala Ser Leu Leu Ala Leu Leu Gln Pro Glu Lys Val
Phe Asp 50 55 60 Lys Ser Gln Asn His Ser Leu Gly Arg Val Glu Arg
Leu Gln Arg Ser 65 70 75 80 Leu Ala Lys Ala Lys Arg Leu Gln Gln Leu
Ala Glu Glu His Lys Trp 85 90 95 Ser Met Gln Glu Leu His Ala Ala
Asn Asp Leu Ile Gly Glu Pro Thr 100 105 110 Pro Tyr Gly Leu His Ala
Ser Met Phe Leu Val Thr Leu Arg Glu Gln 115 120 125 Gly Thr Pro Glu
Gln His Lys Leu Phe Leu Glu Arg Ala Glu Lys Tyr 130 135 140 Glu Ile
Ile Gly Cys Tyr Ala Gln Thr Glu Leu Gly His Gly Ser Asn 145 150 155
160 Val Arg Gly Leu Glu Thr Thr Ala Thr Trp Asn Ser Asn Asp Lys Thr
165 170 175 Phe Thr Ile Asn Ser Pro Thr Leu Thr Ala Ser Lys Trp Trp
Ile Gly 180 185 190 Ser Leu Gly Arg Thr Ala Asn His Ala Val Val Met
Ala Gln Leu Phe 195 200 205 Ile Asp Gly Lys Asn Tyr Gly Pro His Pro
Phe Val Val Gln Val Arg 210 215 220 Asp Leu Glu Thr His Gln Pro Leu
Asp Asn Val Tyr Val Gly Asp Ile 225 230 235 240 Gly Pro Lys Phe Gly
Tyr Asn Thr Met Asp Asn Gly Phe Leu Leu Phe 245 250 255 Asn Asn Val
Lys Ile Pro His Val Asn Met Leu Ala Arg Phe Cys Gln 260 265 270 Val
Asp Lys Glu Thr Asn Gln Tyr Ala Lys Pro Ala Met Pro Ser Leu 275 280
285 Val Phe Gly Thr Met Thr Trp Val Arg Ala Asn Ile Val Leu Asp Ala
290 295 300 Gly Gly Val Leu Ala Arg Gly Val Thr Ile Ala Thr Arg Tyr
Cys Ala 305 310 315 320 Val Arg Arg Gln Phe Gln Asp Arg Asp Ala Asp
Pro His Ala Gly Glu 325 330 335 Thr Gln Val Leu Asn Tyr Lys Met Val
Gln Val Arg Leu Leu Pro Leu 340 345 350 Leu Ala Ser Met Tyr Ala Leu
His Phe Thr Gly Arg Gly Met Met Arg 355 360 365 Leu Tyr Glu Glu Asn
Gln Ser Arg Met Lys Ala Ala Ser Ser Pro Asp 370 375 380 Gln Glu Ser
Arg Gly Ala Gly Pro Glu Gln Leu Arg Ala Gly Ala Asn 385 390 395 400
Leu Leu Ala Asp Leu His Ala Thr Ser Cys Gly Leu Lys Ala Leu Ala 405
410 415 Ser Thr Thr Ala Gly Glu Gly Leu Glu Ile Cys Arg Arg Ala Cys
Gly 420 425 430 Gly His Gly Tyr Ser Ser Tyr Ser Gly Ile Gly Pro Ala
Tyr Ala Asp 435 440 445 Tyr Leu Pro Thr Leu Thr Trp Glu Gly Asp Asn
Tyr Met Leu Thr Gln 450 455 460 Gln Val Ala Arg Tyr Leu Leu Lys Ser
Ala Arg Ala Val Leu Ala Gly 465 470 475 480 Lys Pro Ala Arg Asn Asp
Thr Ser Gln Ile Leu Gln Ala Tyr Leu Asp 485 490 495 Arg Arg Asp Lys
Gly Ala Ser Phe Asp Val Leu Asp Glu Asp Lys Asp 500 505 510 Ile Val
Ala Ala Phe Gly Trp Arg Thr Ala His Leu Thr Phe Glu Ala 515 520 525
Leu Lys His Arg Asp Ala Glu Gln Arg Ser Trp Asn Ser Leu Leu Val 530
535 540 Asp Phe Trp Arg Leu Ser Thr Ala His Ser Gln Tyr Leu Met Val
Lys 545 550 555 560 Asn Phe Tyr Glu Ala Val Ser Ser Pro Glu Leu Ser
Gly Ala Leu Asp 565 570 575 Pro Glu Thr Lys Gly Leu Met His Gln Leu
Phe Arg Leu Phe Ser Leu 580 585 590 His Thr Leu Glu Arg Glu Ala Ala
Glu Phe Phe Ser Ser Gly Ala Val 595 600 605 Thr Val Arg Gln Ile Thr
Leu Thr Arg Thr Thr Ala Val Leu Lys Leu 610 615 620 Leu Asp Asp Ile
Arg Pro His Ala Val Arg Leu Val Asp Ala Trp Ala 625 630 635 640 Ile
Pro Asp Trp Gln Leu Asp Ser Ser Leu Gly Arg Tyr Asp Gly Lys 645 650
655 Val Tyr Glu Asp Leu Phe Arg Arg Ala Ser Glu Glu Asn Pro Val Asn
660 665 670 Glu Leu Val Phe Asp Pro Tyr Pro Trp Asn Ser Ala Leu Leu
Lys Asn 675 680 685 Glu Pro Ala Lys Ser Lys Leu 690 695
48542PRTPenicillium chrysogenum 48Met Ala Lys Thr Phe Ser Lys Glu
Asp Val Ala Ser His Ser Lys Gly 1 5 10 15 Asp Ser Pro Trp Ile Ile
Ile Asp Glu Asp Val Tyr Asp Val Ser Lys 20 25 30 Phe Gln Glu Glu
His Pro Val Leu Gln Arg Val Ala Gly Lys Asp Ala 35 40 45 Ser Lys
Gln Phe Trp Lys Tyr His Asn Glu Gly Ile Leu Lys Lys Tyr 50 55 60
Lys Gly Gln Leu Gln Ile Gly Ser Leu Asp Thr Lys Lys Ala Ala Pro 65
70 75 80 Ala Pro Pro Thr Pro Ala Pro Ala Pro Lys Lys Ala Ala Pro
Glu Pro 85 90 95 Lys Ser Thr Ala Ser Ser Ser Ser Val Thr Pro Pro
Ala Thr Gly Ala 100 105 110 Pro Gln Asp Pro Tyr Gly Glu Leu Ile Pro
Phe Ala Asp Pro Ser Trp 115 120 125 Tyr Gln Gly Tyr Ala Ser Pro Tyr
Phe Asn Glu Ser His Ala Ala Leu 130 135 140 Arg Asp Glu Val Arg Gln
Trp Val Glu Ser Glu Ile Glu Pro Tyr Val 145 150 155 160 Thr Glu Trp
Asp Glu Ala Lys Glu Val Pro Ala His Ile Tyr Lys Gln 165 170 175 Met
Gly Glu Arg Gly Tyr Leu Ala Gly Leu Leu Gly Val His Phe Pro 180 185
190 Glu Lys His Thr Pro His Arg Val Lys Ser Val Ser Pro Asp Arg Trp
195 200 205 Asp Leu Phe His Glu Met Leu Leu Thr Asp Glu Leu Ser Arg
Ala Gly 210 215 220 Ser Gly Gly Leu Val Trp Ser Leu Ile Gly Gly Tyr
Gly Ile Gly Cys 225 230 235 240 Pro Pro Leu Val Lys Phe Gly Lys Lys
Pro Leu Val Asp Arg Ile Leu 245 250 255 Pro Gly Ile Leu Ala Gly Asp
Lys Arg Ile Cys Leu Ala Ile Thr Glu 260 265 270 Pro Asp Ala Gly Ser
Asp Val Ala Asn Leu Gly Cys Glu Ala Lys Leu 275 280 285 Thr Glu Asp
Gly Lys His Tyr Ile Val Asn Gly Glu Lys Lys Trp Ile 290 295 300 Thr
Asn Gly Ile Tyr Ser Asp Tyr Phe Thr Thr Ala Val Arg Thr Gly 305 310
315 320 Lys Asp Gly Met Asn Gly Leu Ser Val Leu Leu Ile Glu Arg Glu
Ala 325 330 335 Gly Gly Val Ser Thr Arg Arg Met Asp Cys Gln Gly Val
Trp Ser Ser 340 345 350 Gly Thr Thr Tyr Val Thr Phe Glu Asp Val Lys
Val Pro Val Glu Asn 355 360 365 Leu Ile Gly Lys Glu Asn Gln Gly Phe
Lys Val Ile Met Thr Asn Phe 370 375 380 Asn His Glu Arg Ile Gly Ile
Val Ile Gln Cys Val Arg Phe Ser Arg 385 390 395 400 Val Cys Tyr Glu
Glu Ser Met Lys Tyr Ala His Lys Arg Lys Thr Phe 405 410 415 Gly Lys
Arg Leu Ile Asp His Pro Val Ile Arg Met Lys Leu Ala His 420 425 430
Met Ala Arg Gln Ile Glu Ala Thr Tyr Asn Trp Leu Glu Asn Ile Ile 435
440 445 Phe Gln Cys Gln Ser Met Glu Asp Thr Glu Ala Met Leu Lys Leu
Gly 450 455 460 Gly Ala Ile Ala Gly Leu Lys Ala Gln Ser Thr Gln Cys
Phe Glu Phe 465 470 475 480 Cys Ala Arg Glu Ala Ser Gln Ile Phe Gly
Gly Leu Ser Tyr Ser Arg 485 490 495 Gly Gly Gln Gly Gly Lys Ile Glu
Arg Leu Tyr Arg Asp Val Arg Ala 500 505 510 Tyr Ala Ile Pro Gly Gly
Ser Glu Glu Ile Met Leu Asp Leu Ser Met 515 520 525 Arg Gln Ser Leu
Arg Val His Gly Met Phe Gly Met Lys Leu 530 535 540
49438PRTPenicillium chrysogenum 49Met Ala Asp Thr Leu Arg Pro Ala
Thr Ala Pro Tyr Ser Glu Pro Leu 1 5 10 15 Leu Pro Gln Leu Asp Val
Arg Asn Pro Tyr Tyr Thr Asp Leu His His 20 25 30 Asn Leu Arg Ala
Thr Val Arg Glu Tyr Val Asp Thr Tyr Ile Ser Pro 35 40 45 Tyr Ala
Ala Glu Trp Glu Glu Ala Gly Gln Val Pro Glu Ala Val Arg 50 55 60
Arg Arg His Cys Lys Leu Gly Tyr Ser Ile Val His Pro Leu Thr Ser 65
70 75 80 Glu Glu Asp Ser Ala Gly Ile Ser Leu Pro Gly Asn Val Pro
Arg Glu 85 90 95 Lys Trp Asp Thr Trp Cys Ser Leu Ile Val Ser Asp
Glu Leu Thr Arg 100 105 110 Val Gly Tyr Val Gly Val Ile Trp Gly Leu
Gly Gly Gly Asn Gly Ile 115 120 125 Gly Cys Pro Pro Val Ala Arg Phe
Gly Asn Ala Glu Gln Arg Lys Lys 130 135 140 Trp Leu Pro Gly Val Ala
Arg Gly Asp Ile Arg Phe Cys Leu Gly Ile 145 150 155 160 Thr Glu Pro
Asp Ala Gly Ser Asp Val Ala Asn Ile Gln Thr Thr Ala 165 170 175 Gln
Arg Asp Gly Asn His Tyr Val Val Asn Gly Ser Lys Lys Trp Ile 180 185
190 Thr Asn Gly Ile Trp Ala Asp Tyr Cys Thr Ala Ala Val Arg Thr Gly
195 200 205 Gly Pro Gly Arg Ser Gly Ile Ser Leu Leu Val Ile Pro Leu
Ala Thr 210 215 220 Ala Gly Val Thr Arg Arg Arg Met His Asn Ser Gly
Val Asn Ala Ser 225 230 235 240 Gly Ser Thr Phe Ile Glu Phe Glu Asp
Val Arg Val Pro Val Glu Asn 245 250 255 Leu Val Gly Gln Glu Asn Lys
Gly Phe Pro Leu Ile Met Ser Asn Phe 260 265 270 Asn Pro Glu Arg Leu
Ala Leu Ala Cys Ala Ser Leu Arg Leu Ala Arg 275 280 285 Val Cys Ala
Glu Asp Ala Tyr Asn Tyr Ala Ile Lys Arg Glu Thr Phe 290 295 300 Gly
Ser Ala Leu Ile Glu Lys Gln Ala Ile Gln Ser Lys Ile Phe Lys 305 310
315 320 Phe Gly Leu Met Ile Glu Pro Ala Tyr Ala Phe Met Glu Gln Leu
Val 325 330 335 Asn Ile Leu Glu Leu Thr Lys Asp Arg Pro Ser Asp Asp
Val Asn Ile 340 345 350 Gly Gly Met Thr Ala Leu Leu Lys Val Met Ser
Thr Arg Ala Leu Glu 355 360 365 Lys Ser Val Arg Glu Ala Gln Gln Ile
Met Gly Gly Ala Gly Tyr Asn 370 375 380 Lys Ala Gly Lys Gly Ala Arg
Ile Glu Gln Ile Ser Arg Asp Ala Arg 385 390 395 400 Val His Val Val
Gly Gly Gly Ser Glu Glu Ile Met Ala Gly Leu Ala 405 410 415 Leu Arg
Glu Glu Thr Lys Ala Ile Arg Thr Arg Arg Lys Ala Leu Glu 420 425 430
Lys Arg Gln Ser Lys Val 435 50453PRTPenicillium chrysogenum 50Met
Asn Phe Asp Leu Pro Ala Asp Leu Lys Thr His Leu Glu Ser Ile 1 5 10
15 Asp Ser Phe Ile His Ser Thr Ile Leu Pro Leu Gln His Ser Asn Asp
20 25 30 Asn Asn Arg Phe Phe Asp His Arg Arg Glu Tyr Glu Arg Thr
Asp Trp 35 40 45 Glu Asn Asn Gly Asn Pro Arg Lys Glu Trp Glu Glu
Leu Leu Gly Glu 50 55 60 Ala Arg Thr Leu Ala Asp Ser Ser Gly Leu
Tyr Arg Phe Ala Leu Pro 65 70 75 80 Arg Val Tyr Gly Gly Gln Ser His
Pro Asp Val Asn Leu Trp Met Ser 85 90 95 Ala Ile Arg Tyr His Leu
Ser Ser Asn Ala Val Tyr Gly Gly Gly Leu 100 105 110 Gly Leu Ala Asn
Asp Leu Gln Asn Glu His Cys Ile Val Gly Asn Phe 115 120 125 Pro Asp
Val Leu Met Leu His His Phe Gly Asn Glu Gln Gln Arg Asn 130 135 140
Thr Leu Ile Pro Ala Arg Leu Arg Gly Glu Phe Arg Thr Thr Phe Gly 145
150 155 160 Leu Thr Glu Pro Asp His Gly Ser Asp Ala Thr Phe Met Ser
Thr Thr 165 170 175 Ala Arg Pro Thr Arg Gly Gly Phe Glu Ile Lys Gly
Ala Lys Lys Trp 180 185 190 Gln Thr Gly Ala His His Cys Thr His Phe
Leu Ile Phe Ala Arg Thr 195 200 205 Ser Gly Lys Ala Gly Ser Ala Gln
Gly Ile Thr Ala Phe Leu Val Pro 210 215 220 Arg Asp Thr Arg Gly Val
Arg Ile Val Ser Tyr Glu Trp Thr Leu Asn 225 230 235 240 Met Pro Thr
Asp His Ala Thr Val Glu Leu Asn Ser Val Trp Val Pro 245 250 255 Glu
Ser Ala Val Leu Gly Ser Ile Asp Gln Gly Leu Ala Ile Ala Gln 260 265
270 Thr Phe Val His Glu Asn Arg Ile Arg Gln Ala Ala Ser Ser Cys Gly
275 280 285 Ala Ala Arg Tyr Cys Leu Asp Arg Ser Ile Asp Arg Ala Arg
Ala Arg 290 295 300 Lys Ile Trp Gly Glu Gly Lys Ser Leu Ala Asp Asn
Gln Ala Ile Gln 305 310 315 320 Phe Pro Val Val Glu Leu Met Thr Gln
Val Glu Met Leu Arg Leu Phe 325 330 335 Ile Leu Lys Thr Ser Trp Glu
Met Asp Arg Ile Val Ala Glu Cys Gln 340 345 350 Ser
Ser Lys Ala Gln Arg Ala Pro Trp Val Glu Ile Glu Gly Arg Leu 355 360
365 Ser Asp Gln Val Ala Met Cys Asn Phe Trp Ala Asn Arg Leu Cys Cys
370 375 380 Gln Ala Ala Asp Arg Ala Ile Gln Ile His Gly Gly Asp Gly
Tyr Ser 385 390 395 400 Arg His Tyr Pro Phe Glu His Ile Tyr Arg His
Phe Arg Arg Tyr Arg 405 410 415 Ile Thr Glu Gly Ala Glu Glu Ile Gln
Met Arg Lys Ile Gly Ala Tyr 420 425 430 Ile Phe Gly Phe Ala Gly Pro
Lys Lys Arg Glu Met Lys His Glu His 435 440 445 Ser Lys Ala Arg Ile
450 51441PRTPenicillium chrysogenum 51Met Ala Tyr Asn Ser Pro Asn
Pro Ile Pro Phe Ser Glu Pro Pro Tyr 1 5 10 15 Ile Arg Gly Leu Pro
Ser Pro Tyr Ile Thr Pro Ala His Arg Arg Phe 20 25 30 Gln Gln Ala
Cys Arg Lys Phe Ala Thr Glu Asn Leu Ile Gln His Ala 35 40 45 Leu
Glu Trp Glu Arg Glu Gly Thr Val Pro Glu His Val Phe His Thr 50 55
60 Phe Cys Lys His Asn Met Leu Leu Pro Asn Met Pro Ala Pro Leu Pro
65 70 75 80 Val Asp Trp Leu Lys Arg Leu Gly Ile Asn Asp Ile Leu Gly
Val Lys 85 90 95 Val Glu Asp Trp Asp Tyr Ile Tyr Thr Gly Ile Tyr
Cys Asp Glu Met 100 105 110 Ala Arg Ser Gly Leu Ser Gly Pro Ser Gly
Ser Leu Asn Ala Gly Phe 115 120 125 Ala Phe Gly Ile Ala Pro Ile Tyr
Lys Phe Gly Ser Thr Glu Leu Gln 130 135 140 Glu Arg Phe Leu Pro Glu
Leu Leu Thr Gly Lys Lys Arg Gly Cys Ile 145 150 155 160 Ala Ile Thr
Glu Pro Glu Ala Gly Ser Asp Val Ala Asn Ile Thr Thr 165 170 175 Thr
Ala Val Lys Ser Ala Asp Gly Gln His Tyr Ile Leu Asn Gly Ser 180 185
190 Lys Lys Trp Ile Thr Asn Gly Ile Trp Ser Asp Tyr Ala Thr Met Ala
195 200 205 Val Arg Thr Gly Gly Pro Gly Ala Ala Gly Leu Ser Val Leu
Val Val 210 215 220 Pro Leu Lys Gly His Pro Gly Val Ser Met Arg Arg
Leu Lys Val Ser 225 230 235 240 Gly Gln Ile Thr Gly Gly Thr Thr Tyr
Ile Glu Leu Asp Asp Val Lys 245 250 255 Val Pro Val Ser Asn Ile Ile
Gly Lys Glu Gly Asp Gly Met Arg Ile 260 265 270 Ile Met Thr Asn Phe
Asn His Glu Arg Leu Val Ile Ala Val Gly Val 275 280 285 Thr Arg Gln
Ala Arg Val Ala Leu Ser Ala Ala Phe Ser Tyr Cys Leu 290 295 300 Lys
Arg Glu Ala Phe Gly Lys Thr Leu Met Asp Gln Pro Val Val Arg 305 310
315 320 His Arg Leu Ala Lys Ala Gly Ala Glu Leu Glu Ser Met Trp Ala
Trp 325 330 335 Val Glu Gln Ile Leu Tyr Gln Leu Val His Leu Ser Lys
Glu Glu Gly 340 345 350 Asp Arg Gln Leu Gly Gly Leu Thr Ala Leu Ala
Lys Ala Lys Ser Ala 355 360 365 Met Val Leu Asn Glu Cys Ala Gln Thr
Ala Val Leu Leu Phe Gly Gly 370 375 380 Asn Gly Phe Thr Lys Thr Gly
Gln Gly Glu Leu Val Glu Ala Ile Leu 385 390 395 400 Arg Asp Val Pro
Gly Ala Arg Ile Pro Gly Gly Ser Glu Asp Val Leu 405 410 415 Leu Asp
Leu Ser Val Arg Gln Leu Val Lys Leu Tyr Gln Ala Glu Glu 420 425 430
Lys Lys Leu Ser Lys Asn Ala Lys Ile 435 440 52439PRTPenicillium
chrysogenum 52Met Tyr Arg Ser Gln Ile Gln Arg Ala Leu Arg Ser Gln
Trp Pro Ala 1 5 10 15 Leu Arg Gln Leu Gln Cys Arg Thr Gly Leu Ser
Pro Arg Ala Arg Ala 20 25 30 Ala Phe Ser Thr Ser Gly Arg Arg Asp
Ile Met Gly Met Thr Gly Phe 35 40 45 Thr Asp Glu Gln Leu Thr Val
Arg Glu Ala Ile Ser His Ile Cys Ser 50 55 60 Arg Phe Pro Asn Thr
Tyr Trp Gln Glu Arg Asp Gln Gln Glu Lys Asp 65 70 75 80 Pro Lys Glu
Phe His Ala Ala Leu Ala Lys Asp Gly Trp Leu Gly Ile 85 90 95 Ala
Leu Pro Glu Ser Leu Gly Gly Ala Gly Leu Gly Ile Ser Glu Ala 100 105
110 Thr Met Met Met Gln Thr Ile Thr Gln Ser Gly Ala Gly Met Ala Gly
115 120 125 Ala Gln Ala Ile His Ala Asn Val Tyr Ala Thr Gln Pro Leu
Ala Lys 130 135 140 Phe Gly Thr Lys Glu Gln Leu Glu Thr Thr Ile Pro
Asn Ile Ile Asn 145 150 155 160 Gly Thr Trp Arg Thr Cys Phe Gly Val
Thr Glu Pro Asn Thr Gly Leu 165 170 175 Glu Thr Leu Lys Leu Thr Thr
Leu Ala Ser Lys Thr Asp Asp Gly Tyr 180 185 190 Ser Val Thr Gly Gln
Lys Ile Trp Ile Thr Cys Ala Gln Val Ala Ser 195 200 205 Lys Met Ile
Leu Leu Ala Arg Thr Thr Pro Leu Glu Glu Val Lys Lys 210 215 220 Ser
Ser Glu Gly Leu Ser Leu Phe Cys Ile Asp Ile Asp Arg Glu Asn 225 230
235 240 Pro Gly Leu Asp Leu Arg Lys Ile Lys Lys Met Gly Gly Arg Ala
Val 245 250 255 Asp Ala Asn Glu Val Phe Phe Asp His Tyr Lys Ile Pro
Ala Asn Thr 260 265 270 Leu Ile Gly Glu Glu Asn Gln Gly Phe Lys Ile
Ile Leu His Gly Met 275 280 285 Asn Ala Glu Arg Cys Leu Leu Ala Gly
Glu Ala Leu Gly Leu Gly Tyr 290 295 300 Ala Ala Leu Glu Lys Ala Ser
Gln Tyr Ala Lys Asp Arg Val Val Phe 305 310 315 320 Gly Arg Pro Ile
Gly Gln Asn Gln Gly Val Ala His Pro Leu Ala Asp 325 330 335 Ala Phe
Met Lys Leu Glu Ala Ala Lys Leu Ala Thr Tyr His Ala Ala 340 345 350
Arg Leu Tyr Asp Thr Asn Asp Gly Ser Val Pro Phe His Glu Ile Gly 355
360 365 Val Ala Cys Asn Ser Ala Lys Tyr Leu Ala Ala Glu Ala Ala Phe
Thr 370 375 380 Ala Cys Glu Arg Ala Val Leu Ala His Gly Gly Met Gly
Tyr Ala Val 385 390 395 400 Glu Tyr Asp Val Glu Arg Tyr Met Arg Glu
Cys Phe Val Pro Arg Ile 405 410 415 Ala Pro Val Ser Arg Glu Met Ile
Leu Asn Tyr Val Ser Glu Lys Val 420 425 430 Leu Asp Leu Pro Arg Ser
Tyr 435 53446PRTPenicillium chrysogenum 53Met Ser Ala Ser Ser Arg
Ile Pro Pro Ile Ala Gln Pro Phe Val Ser 1 5 10 15 Glu His Ala Lys
Arg Thr Leu Asp Leu Val Glu Glu Phe Val Glu Lys 20 25 30 Asp Cys
Ile Pro Ala Asp Thr Val Phe Ser Ala Gln Leu Gly Glu Gly 35 40 45
Glu Lys Arg Trp Thr Thr Thr Pro Thr Val Leu Glu Gly Leu Lys Glu 50
55 60 Lys Ala Lys Lys Leu Gly Leu Trp Asn Met Phe Leu Pro Lys Asn
His 65 70 75 80 Phe Thr Gln Gly Ala Gly Phe Ser Asn Leu Glu Tyr Gly
Leu Met Ala 85 90 95 Glu Leu Leu Gly Lys Ser Lys Val Ala Ser Glu
Ala Thr Asn Asn Ala 100 105 110 Ala Pro Asp Thr Gly Asn Met Glu Val
Phe Ala Lys Tyr Gly Asn Asp 115 120 125 Ala Gln Lys Lys Gln Trp Leu
Ala Pro Leu Leu Glu Gly Lys Ile Arg 130 135 140 Ser Ala Phe Leu Met
Thr Glu Pro Asp Val Ala Ser Ser Asp Ala Thr 145 150 155 160 Asn Ile
Glu Leu Asn Ile Arg Arg Glu Gly Asn Glu Tyr Val Leu Asn 165 170 175
Gly Ser Lys Trp Trp Ser Ser Gly Ala Gly Asp Pro Arg Cys Ala Ile 180
185 190 Tyr Leu Val Met Gly Lys Thr Asp Pro Thr Asn Pro Asp Thr Tyr
Lys 195 200 205 Gln Gln Ser Val Ile Leu Val Pro Ala Gly Leu Pro Gly
Ile Thr Val 210 215 220 His Arg Met Leu Thr Val Tyr Gly Tyr Asp Asp
Ala Pro His Gly His 225 230 235 240 Gly His Ile Thr Phe Lys Asp Val
Arg Val Pro Ala Ser Asn Met Val 245 250 255 Leu Gly Glu Gly Arg Gly
Phe Glu Ile Ile Gln Gly Arg Leu Gly Pro 260 265 270 Gly Arg Ile His
His Ala Met Arg Ala Ile Gly Ala Ala Glu Arg Ala 275 280 285 Leu Glu
Trp Leu Ile Ala Arg Val Asn Asp Glu Arg Lys Met Thr Phe 290 295 300
Gly Lys Pro Leu Val Ala His Gly Val Ile Leu Glu Trp Ile Ala Lys 305
310 315 320 Ser Arg Ile Glu Val Asp Ala Ala Arg Leu Ile Val Leu Asn
Ala Ala 325 330 335 Ile Lys Ile Asp Gln Gly Asp Ala Lys Ser Ala Leu
Lys Glu Ile Ala 340 345 350 Gln Ala Lys Val Leu Val Pro Gln Thr Ala
Leu Thr Ile Ile Asp Arg 355 360 365 Ala Val Gln Ala Tyr Gly Ala Ala
Gly Val Cys Gln Asp Thr Pro Leu 370 375 380 Ala Tyr Leu Trp Ala Gly
Ile Arg Thr Leu Arg Ile Ala Asp Gly Pro 385 390 395 400 Asp Glu Val
His Leu Gln Gln Leu Gly Lys Arg Glu Asn Lys Ala Arg 405 410 415 Lys
Asp Ala Val Thr Ala Lys Leu Asn Trp Gln Arg Glu Glu Ala Asp 420 425
430 Arg Leu Leu Ala Ala Ser Gly Phe Lys Pro Lys Ser His Leu 435 440
445 54513PRTPenicillium chrysogenum 54Met Pro Ser Glu Thr Leu Thr
Arg Ala Glu Val Ala Lys His Asn Thr 1 5 10 15 Glu Asp Ser Leu Trp
Cys Ile Ile Asp His Gln Val Tyr Asp Leu Thr 20 25 30 Asp Phe Val
Asp Ala His Pro Gly Gly Gly Val Val Leu Ala Gln Val 35 40 45 Ala
Gly Lys Asp Ala Thr Ser Asp Phe Tyr Asn Leu His Arg Gln Glu 50 55
60 Val Leu Glu Lys Tyr Arg Asp Gln Leu Cys Ile Gly Val Val Glu Gly
65 70 75 80 Glu Lys Pro Glu Val Ile Arg Pro Phe Pro Gly Ala Leu Ser
Pro Val 85 90 95 Pro Tyr Ala Glu Pro Leu Trp Leu Arg Pro Gln Phe
Lys Ser Pro Tyr 100 105 110 Tyr Lys Glu Thr His Arg Asn Leu Gln Lys
Ala Ile Arg Glu Phe Thr 115 120 125 Asp Lys Tyr Val Thr Pro Glu Ala
Gln Glu Lys Glu Gln Asp Gly Ser 130 135 140 Tyr Ile Ser Gln Glu Leu
Ile Asn Arg Met Ala Glu Thr Asn Ile Leu 145 150 155 160 Ala Met Arg
Leu Gly Pro Gly Lys His Leu His Gly Arg Thr Leu Leu 165 170 175 Gly
Gly Val Val Asp Gly Lys Glu Phe Asp Tyr Leu His Asp Met Ile 180 185
190 Ile Val Gln Glu Met Val Arg Ala Asn Ala Arg Gly Phe Gln Asp Gly
195 200 205 Asn Met Ala Gly Met Ala Ile Ser Leu Thr Ala Val Gln Gln
Trp Leu 210 215 220 His Asp Pro Val Leu Lys Glu Arg Leu Asn Asp Glu
Val Leu Ser Gly 225 230 235 240 Arg Lys Lys Met Cys Leu Ala Ile Thr
Glu Ala Phe Ala Gly Ser Asp 245 250 255 Val Ala Gly Leu Lys Thr Thr
Ala Glu Lys Thr Pro Asp Gly Lys His 260 265 270 Tyr Ile Val Asn Gly
Thr Lys Lys Trp Ile Thr Asn Gly Met Phe Ala 275 280 285 Asp Tyr Phe
Val Thr Gly Cys Arg Thr Glu Lys Gly Phe Ser Val Leu 290 295 300 Leu
Ile Pro Arg Gly Glu Gly Val Glu Thr Lys Gln Ile Lys Thr Ser 305 310
315 320 Tyr Ser Thr Ala Ala Ala Thr Ala Phe Val Glu Phe Asp Asn Val
Lys 325 330 335 Val Pro Val Gln Asn Leu Leu Gly Glu Glu His Lys Gly
Phe Ile Val 340 345 350 Ile Met Ser Asn Phe Asn His Glu Arg Phe Met
Met Val Ala Ala Val 355 360 365 Val Arg Met Ser Met Met Val Val Glu
Glu Thr Met Lys Trp Ser Asn 370 375 380 Gln Arg Ile Val Phe Gly Lys
Lys Leu Ile Glu Gln Pro Val Ile Arg 385 390 395 400 Gln Lys Ile Ala
Arg Met Ile Ser Leu Ala Glu Ser Asn Gln Ala Trp 405 410 415 Leu Glu
Ser Ile Ala Tyr Gln Met Cys Asn Met Thr Tyr Ala Gln Gln 420 425 430
Ala Lys Leu Leu Gly Gly Pro Ile Gly Leu Leu Lys Ser His Cys Thr 435
440 445 Gln Ala Ala Gly Glu Ile Ala Ser Leu Ala Thr Asn Ile Phe Gly
Gly 450 455 460 Arg Gly Leu Thr Gln Ser Gly Met Gly Lys Val Ile Glu
Met Phe His 465 470 475 480 Arg Thr Tyr Lys Phe Asp Ala Ile Leu Gly
Gly Thr Glu Glu Ile Leu 485 490 495 Ala Asp Leu Gly Val Arg Gln Ala
Met Lys Asn Phe Pro Lys Ser Met 500 505 510 Leu 55436PRTPenicillium
chrysogenum 55Met Ala Ser Ile Ile Arg Ala Leu Arg Pro Leu Ser Arg
Asn Pro Ser 1 5 10 15 Val Arg Leu Ala Gly Lys Arg Leu Ala Ala Gly
Arg Pro Val Gln Ser 20 25 30 Ala Tyr Ala Phe Ser Thr Thr Pro Arg
Arg Arg Glu Val Asp Leu Ser 35 40 45 Glu Leu Thr Pro Thr Pro Ile
Thr Leu Leu Ser Glu Thr Glu Ser Leu 50 55 60 Met Ala Asp Ser Val
Ser Lys Phe Ala Val Glu Gln Ile Gly Pro Lys 65 70 75 80 Val Arg Glu
Met Asp Glu Ala Glu Thr Met Asp Ala Lys Val Val Glu 85 90 95 Gln
Leu Phe Glu Gln Gly Leu Met Gly Ile Glu Val Pro Glu Glu Phe 100 105
110 Gly Gly Ala Gly Met Asn Phe Thr Ala Ala Ile Val Ala Ile Glu Glu
115 120 125 Leu Ala Arg Val Asp Pro Ser Val Ser Val Leu Val Asp Val
His Asn 130 135 140 Thr Leu Val Asn Thr Ala Ile Met Lys Tyr Gly Asp
Ala Lys Ala Gln 145 150 155 160 Arg Thr Trp Leu Pro Lys Leu Thr Thr
Gly Thr Val Gly Ser Phe Cys 165 170 175 Leu Ser Glu Pro Ala Ser Gly
Ser Asp Ala Phe Ala Leu Gln Thr Lys 180 185 190 Ala Glu Lys Thr Ala
Asp Gly Tyr Lys Leu Asn Gly Ser Lys Met Trp 195 200 205 Ile Thr Asn
Ser Met Glu Ala Gly Val Phe Ile Val Phe Ala Asn Ile 210 215 220 Asp
Pro Ser Lys Gly Tyr Lys Gly Ile Thr Ala Phe Ile Val Glu Lys 225 230
235 240 Asp Thr Pro Gly Phe Ser Ile Ala Lys Lys Glu Lys Lys Leu Gly
Ile 245 250 255 Arg Ala Ser Ser Thr Cys Val Leu Asn Phe Asp Asp Cys
Val Ile Pro 260 265 270 Lys Ser Asn Leu Leu Gly Glu Glu Gly Gln Gly
Tyr Lys Tyr Ala Ile 275 280 285 Ser Val Leu Asn Glu Gly Arg Ile Gly
Ile Ala Ala Gln Met Thr Gly 290 295 300 Leu Ala Leu Gly Ala Trp Glu
Asn Ala Ala Arg Tyr Val Trp Asn Asp 305 310 315 320 Arg Arg Gln Phe
Gly Glu Leu Ile Gly Asn Phe Gln Gly Met Gln His 325 330 335 Gln Ile
Ala Gln Ala Tyr Thr Glu Ile Ala Ala Ala Arg Ala Leu
Val 340 345 350 Tyr Asn Ala Ala Arg Lys Lys Glu Ala Gly Gln Asp Phe
Val Gln Asp 355 360 365 Ala Ala Met Ala Lys Leu Tyr Ala Ser Gln Val
Ala Gly Arg Val Ser 370 375 380 Ser Ser Ala Val Glu Trp Met Gly Gly
Met Gly Phe Val Arg Glu Gly 385 390 395 400 Ile Ala Glu Lys Met Phe
Arg Asp Ser Lys Ile Gly Ala Ile Tyr Glu 405 410 415 Gly Thr Ser Asn
Ile Gln Leu Gln Thr Ile Ala Lys Leu Leu Gln Lys 420 425 430 Gln Tyr
Thr Asn 435 56429PRTPenicillium chrysogenum 56Met Ala Ser Leu Thr
Leu Pro Ser Leu Leu Arg Thr Ser Thr Arg Ala 1 5 10 15 Val Arg Leu
Asn Arg Thr Pro Ala Leu Thr Pro Cys Phe Arg Ser Ile 20 25 30 Ser
Thr Lys His Pro Lys Gly Phe Ile Pro Pro Ser Glu Asp Asp Leu 35 40
45 Leu Glu Leu Arg Glu Arg Val Gln Asp Phe Thr Arg Arg Glu Ile Pro
50 55 60 Ala Asp Val Ala Ala Arg Thr Asp Glu Gln Asn Glu Phe Pro
Ala Glu 65 70 75 80 Met Trp Arg Lys Met Gly Asp Ala Gly Phe Leu Gly
Val Thr Ala Asn 85 90 95 Glu Glu Tyr Gly Gly Leu Gly Met Gly Tyr
Gln Ala His Cys Val Val 100 105 110 Met Glu Glu Ile Ser Arg Ala Ser
Gly Ser Ile Gly Leu Ser Tyr Ala 115 120 125 Ala His Ser Gln Leu Cys
Val Asn Gln Leu Ser Leu Asn Gly Ser Thr 130 135 140 Glu Gln Lys Glu
Arg Ile Leu Pro Gly Leu Leu Ser Gly Glu Lys Val 145 150 155 160 Gly
Ala Leu Ala Met Ser Glu His Ser Ala Gly Ser Asp Val Val Ser 165 170
175 Met Lys Thr Thr Ala Lys Glu Val Asp Gly Gly Trp Leu Leu Asn Gly
180 185 190 Thr Lys Met Trp Ile Thr Asn Gly Pro Asp Ala Asp Tyr Ile
Val Val 195 200 205 Tyr Ala Lys Thr Glu Pro Glu Leu Gly Ser Lys Gly
Ile Thr Ala Phe 210 215 220 Leu Val Glu Lys Asp Phe Lys Gly Phe Ser
Cys Ala Arg Lys Leu Asp 225 230 235 240 Lys Leu Gly Met Arg Gly Ser
Asn Thr Gly Glu Leu Ile Phe Glu Asp 245 250 255 Val Phe Val Pro Arg
Glu Asn Leu Leu Gly Glu Val Asn Arg Gly Val 260 265 270 Arg Val Leu
Met Glu Gly Leu Asp Leu Glu Arg Leu Val Leu Ser Ala 275 280 285 Gly
Pro Leu Gly Ile Met Gln Ala Ala Leu Asp Leu Val Leu Pro Tyr 290 295
300 Thr His Val Arg Lys Gln Phe Gly Ala Pro Ile Ala His Asn Gln Leu
305 310 315 320 Val Gln Gly Lys Leu Ala Asp Met Tyr Thr Lys Leu Ala
Ala Ser Arg 325 330 335 Ala Tyr Thr Tyr Ala Thr Ala Arg Gln Val Asp
Asn Ala Ala Val Glu 340 345 350 Pro Gly Glu Leu Thr Val Arg Thr Gln
Asp Cys Ala Gly Ala Ile Leu 355 360 365 Tyr Ala Ala Glu Arg Ala Thr
Glu Cys Thr Leu Asp Ala Ile Gln Leu 370 375 380 Met Gly Gly Ser Gly
Tyr Ile Asn Glu Ile Pro Ala Gly Arg Leu Leu 385 390 395 400 Arg Asp
Ala Lys Leu Tyr Glu Ile Gly Ala Gly Thr Ser Glu Ile Arg 405 410 415
Arg Met Val Ile Gly Arg Ala Phe Asn Lys Glu Tyr Ala 420 425
57405PRTPenicillium Chrysogenum 57Met Phe Ser Arg Ser Val Leu Gln
Thr Ala Thr Arg Ser Val Arg Pro 1 5 10 15 Ala Ser Ala Arg Ala Val
Pro Gln Leu Gly Lys Ala Pro Phe Gly Arg 20 25 30 Arg Tyr Val Ser
Val Tyr Gly Tyr Thr Gln Ala Lys Ala Leu Ile Tyr 35 40 45 Ser Lys
Tyr Gly Glu Pro Lys Asp Val Leu Arg Leu His Lys His Ser 50 55 60
Ile Ser Ala Pro His Ala Thr Gln Val Asn Leu Arg Leu Leu Thr Ala 65
70 75 80 Pro Met Asn Pro Ala Asp Val Asn Gln Ile Gln Gly Val Tyr
Pro Ser 85 90 95 Lys Pro Pro Phe Gln Thr Glu Leu Gly Asn Val Glu
Pro Ala Ala Val 100 105 110 Gly Gly Asn Glu Gly Ala Phe Glu Val Leu
Ser Thr Gly Ala Gly Val 115 120 125 Lys Asn Leu Ser Lys Gly Asp Trp
Val Ile Met Lys Arg Thr Gly Leu 130 135 140 Gly Thr Trp Arg Thr His
Ala Gln Leu Asp Glu Ser Gln Leu Ile Lys 145 150 155 160 Val Glu Asn
Lys Glu Gly Leu Thr Pro Leu Gln Val Gly Thr Val Ser 165 170 175 Val
Asn Pro Val Thr Ala Tyr Arg Met Leu Arg Asp Phe Cys Glu Trp 180 185
190 Asp Trp Met Arg Ala Gly Glu Glu Trp Val Ile Gln Asn Gly Ala Asn
195 200 205 Ser Gly Val Gly Arg Ala Ala Ile Gln Leu Gly Arg Glu Trp
Gly Ile 210 215 220 Lys Thr Leu Asn Val Ile Arg Gln Arg Lys Thr Pro
Glu Glu Thr Glu 225 230 235 240 Ala Leu Lys Gln Glu Leu Arg Asp Leu
Gly Ala Thr Val Val Ile Thr 245 250 255 Glu Glu Glu Met Leu Asn Gly
Asn Phe Arg Asp Met Val His Glu Phe 260 265 270 Thr Arg Lys Gly Arg
Glu Pro Ile Arg Leu Ala Leu Asn Cys Val Gly 275 280 285 Gly Lys Asn
Ala Thr Ala Leu Ala Lys Thr Leu Ala Pro Asp Ser His 290 295 300 Met
Val Thr Tyr Gly Ala Met Ser Lys Gln Pro Val Ala Leu Pro Ser 305 310
315 320 Gly Leu Leu Ile Phe Lys Asn Leu Ala Phe Asp Gly Phe Trp Val
Ser 325 330 335 Lys Trp Gly Asp Lys Asn Pro Gln Leu Lys Glu Ser Thr
Ile Lys Asp 340 345 350 Val Leu Gln Leu Thr Arg Ser Gly Lys Phe Lys
Asp Ile Pro Val Asp 355 360 365 Glu Val Lys Trp Asn Trp Glu Thr Glu
Gly Pro Glu Leu Ala Glu Ser 370 375 380 Val Gln Gly Thr Leu Gly Gly
Tyr Arg Ser Gly Lys Gly Val Phe Thr 385 390 395 400 Phe Ser Gly Gly
Asp 405 58373PRTBos taurus 58Met Trp Val Cys Gly Ala Leu Cys Arg
Thr Arg Ala Pro Ala Gln Leu 1 5 10 15 Gly Gln Arg Leu Leu Pro Glu
Ser Arg Arg Arg Arg Pro Ala Ser Ala 20 25 30 Ser Phe Ser Ala Ser
Ala Glu Pro Ser Arg Val Arg Ala Leu Val Tyr 35 40 45 Gly His His
Gly Asp Pro Ala Lys Val Val Glu Leu Lys Asn Leu Glu 50 55 60 Leu
Ala Ala Val Gly Gly Ser His Val His Val Lys Met Leu Ala Ala 65 70
75 80 Pro Ile Asn Pro Ser Asp Ile Asn Met Ile Gln Gly Asn Tyr Gly
Leu 85 90 95 Leu Pro Gln Leu Pro Ala Val Gly Gly Asn Glu Gly Val
Gly Gln Val 100 105 110 Val Ala Val Gly Ser Gly Val Thr Gly Val Lys
Pro Gly Asp Trp Val 115 120 125 Ile Pro Ala Asn Pro Gly Leu Gly Thr
Trp Arg Thr Glu Ala Val Phe 130 135 140 Gly Glu Glu Glu Leu Ile Thr
Val Pro Ser Asp Ile Pro Leu Gln Ser 145 150 155 160 Ala Ala Thr Leu
Gly Val Asn Pro Cys Thr Ala Tyr Arg Met Leu Val 165 170 175 Asp Phe
Glu Arg Leu Arg Pro Arg Asp Ser Ile Ile Gln Asn Ala Ser 180 185 190
Asn Ser Gly Val Gly Gln Ala Val Ile Gln Ile Ala Ala Ala Arg Gly 195
200 205 Leu Arg Thr Ile Asn Val Leu Arg Asp Thr Pro Asp Leu Gln Lys
Leu 210 215 220 Thr Asp Thr Leu Lys Asn Leu Gly Ala Asn His Val Val
Thr Glu Glu 225 230 235 240 Glu Leu Arg Lys Pro Glu Met Lys Ser Phe
Phe Lys Asp Val Pro Gln 245 250 255 Pro Arg Leu Ala Leu Asn Cys Val
Gly Gly Lys Ser Ser Thr Glu Leu 260 265 270 Leu Arg His Leu Ala Pro
Gly Gly Thr Met Val Thr Tyr Gly Gly Met 275 280 285 Ala Lys Gln Pro
Val Ile Ala Ser Val Ser Gln Leu Ile Phe Lys Asp 290 295 300 Leu Lys
Leu Arg Gly Phe Trp Leu Ser Gln Trp Lys Lys Asp His Ser 305 310 315
320 Pro Asp Gln Phe Lys Glu Leu Ile Leu Thr Leu Cys Asp Leu Ile Arg
325 330 335 Arg Gly Gln Leu Thr Ala Pro Ala Cys Ser Glu Val Pro Leu
Gln Asp 340 345 350 Tyr Leu Cys Ala Leu Glu Ala Ser Thr Gln Pro Phe
Val Ser Ser Lys 355 360 365 Gln Ile Leu Thr Met 370 59302PRTCavia
sp. 59Met Gly Ser Trp Thr Lys Cys Gln Ser Cys Leu Ala Pro Gly Leu
Leu 1 5 10 15 Gln Asn Arg Ala Ala Ile Val Thr Gly Gly Gly Thr Gly
Ile Gly Lys 20 25 30 Ala Ile Ala Lys Glu Leu Leu His Leu Gly Cys
Asn Val Val Ile Ala 35 40 45 Ser Arg Lys Phe Asp Arg Leu Arg Ala
Ala Ala Glu Glu Leu Lys Ala 50 55 60 Thr Leu Pro Pro Ser Asn Lys
Ala Glu Val Thr Pro Ile Gln Cys Asn 65 70 75 80 Ile Arg Lys Glu Glu
Glu Val Asn Asn Leu Met Lys Ser Thr Leu Ala 85 90 95 Leu Tyr Gly
Lys Ile Asp Phe Leu Val Asn Asn Gly Gly Gly Gln Phe 100 105 110 Trp
Ser Ser Pro Glu His Ile Ser Ser Lys Gly Trp His Ala Val Ile 115 120
125 Glu Thr Asn Leu Thr Gly Thr Phe Tyr Met Cys Lys Ala Ala Tyr Asn
130 135 140 Ser Trp Met Lys Glu His Gly Gly Ala Ile Val Asn Ile Ile
Ile Leu 145 150 155 160 Leu Asn Gly Gln Pro Phe Val Ala His Ser Gly
Ala Ala Arg Gly Gly 165 170 175 Val Tyr Asn Leu Thr Lys Ser Leu Ala
Leu Gly Trp Ala Arg Ser Gly 180 185 190 Ile Arg Ile Asn Cys Val Ala
Pro Gly Thr Val Tyr Ser Gln Thr Ala 195 200 205 Met Asp Asn Tyr Gly
Asp Met Gly Lys Thr Leu Phe Ala Asp Ala Phe 210 215 220 Gln Lys Ile
Pro Ala Lys Arg Leu Gly Val Pro Glu Glu Val Ser Ser 225 230 235 240
Leu Val Cys Phe Leu Leu Ser Pro Ala Ala Ser Phe Ile Thr Gly Gln 245
250 255 Leu Val Asn Val Asp Gly Gly Gln Ser Leu Tyr Cys Gln Asn His
Asp 260 265 270 Ile Pro Asp His Asp Asn Trp Pro Glu Gly Val Gly Asp
Leu Ser Thr 275 280 285 Val Lys Lys Met Lys Glu Ser Phe Lys Gln Lys
Ala Lys Leu 290 295 300 60386PRTCandida tropicalis 60Met Tyr Ser
Val Leu Lys Gln Ser Ile Arg Pro Arg Leu Leu Ala Thr 1 5 10 15 His
Asn Gln Phe Arg Thr Met Ile Thr Ala Gln Ala Val Leu Tyr Thr 20 25
30 Gln His Gly Glu Pro Lys Asp Val Leu Phe Thr Gln Ser Phe Glu Ile
35 40 45 Asp Asp Asp Asn Leu Ala Pro Asn Glu Val Ile Val Lys Thr
Leu Gly 50 55 60 Ser Pro Val Asn Pro Ser Asp Ile Asn Gln Ile Gln
Gly Val Tyr Pro 65 70 75 80 Ser Lys Pro Ala Lys Thr Thr Gly Phe Gly
Thr Thr Glu Pro Ala Ala 85 90 95 Pro Cys Gly Asn Glu Gly Leu Phe
Glu Val Ile Lys Val Gly Ser Asn 100 105 110 Val Ser Ser Leu Glu Ala
Gly Asp Trp Val Ile Pro Ser His Val Asn 115 120 125 Phe Gly Thr Trp
Arg Thr His Ala Leu Gly Asn Asp Asp Asp Phe Ile 130 135 140 Lys Leu
Pro Asn Pro Ala Gln Ser Lys Ala Asn Gly Lys Pro Asn Gly 145 150 155
160 Leu Thr Ile Asn Gln Gly Ala Thr Ile Ser Val Asn Pro Leu Thr Ala
165 170 175 Tyr Leu Met Leu Thr His Tyr Val Lys Leu Thr Pro Gly Lys
Asp Trp 180 185 190 Phe Ile Gln Asn Gly Gly Thr Ser Ala Val Gly Lys
Tyr Ala Ser Gln 195 200 205 Ile Gly Lys Leu Leu Asn Phe Asn Ser Ile
Ser Val Ile Arg Asp Arg 210 215 220 Pro Asn Leu Asp Glu Val Val Ala
Ser Leu Lys Glu Leu Gly Ala Thr 225 230 235 240 Gln Val Ile Thr Glu
Asp Gln Asn Asn Ser Arg Glu Phe Gly Pro Thr 245 250 255 Ile Lys Glu
Trp Ile Lys Gln Ser Gly Gly Glu Ala Lys Leu Ala Leu 260 265 270 Asn
Cys Val Gly Gly Lys Ser Ser Thr Gly Ile Ala Arg Lys Leu Asn 275 280
285 Asn Asn Gly Leu Met Leu Thr Tyr Gly Gly Met Ser Phe Gln Pro Val
290 295 300 Thr Ile Pro Thr Ser Leu Tyr Ile Phe Lys Asn Phe Thr Ser
Ala Gly 305 310 315 320 Phe Trp Val Thr Glu Leu Leu Lys Asn Asn Lys
Glu Leu Lys Thr Ser 325 330 335 Thr Leu Asn Gln Ile Ile Ala Trp Tyr
Glu Glu Gly Lys Leu Thr Asp 340 345 350 Ala Lys Ser Ile Glu Thr Leu
Tyr Asp Gly Thr Lys Pro Leu His Glu 355 360 365 Leu Tyr Gln Asp Gly
Val Ala Asn Ser Lys Asp Gly Lys Gln Leu Ile 370 375 380 Thr Tyr 385
61379PRTClostridium kluyveri 61Met Asp Phe Thr Leu Thr Asn Glu Gln
Lys Phe Val Glu Gln Met Val 1 5 10 15 Ser Glu Phe Thr Glu Asn Glu
Val Lys Pro Ile Ala Ala Glu Ile Asp 20 25 30 Glu Thr Glu Arg Phe
Pro Leu Glu Thr Val Glu Lys Phe Ala Lys Tyr 35 40 45 Gly Met Met
Gly Met Pro Phe Pro Val Glu Tyr Gly Gly Ser Gly Thr 50 55 60 Asp
Tyr Leu Ser Tyr Ile Ile Ala Val Glu Gly Leu Ala Lys Ser Cys 65 70
75 80 Thr Ser Ser Ser Thr Ile Leu Ser Ala His Thr Ser Leu Cys Ala
Ala 85 90 95 Pro Ile Tyr Asp Trp Gly Thr Glu Glu Gln Lys Gln Lys
Tyr Leu Val 100 105 110 Pro Leu Ala Lys Gly Glu Lys Leu Gly Ala Phe
Gly Leu Thr Glu Pro 115 120 125 Asn Ala Gly Thr Asp Ala Ala Gly Gln
Gln Thr Thr Ala Val Leu Glu 130 135 140 Gly Asp His Tyr Val Leu Asn
Gly Gln Lys Ile Phe Ile Thr Asn Gly 145 150 155 160 Ala Tyr Ala Asp
Thr Phe Val Ile Phe Ala Met Thr Asp Arg Ser Lys 165 170 175 Gly Thr
Arg Gly Ile Thr Ala Phe Ile Val Glu Lys Asp Phe Pro Gly 180 185 190
Phe Ser Ile Gly Lys Ser Glu Asp Lys Leu Gly Ile Arg Ala Ser Ser 195
200 205 Thr Thr Glu Leu Ile Phe Glu Asn Cys Ile Val Pro Lys Glu Asn
Met 210 215 220 Leu Gly Lys Glu Gly Lys Gly Phe Thr Val Ala Met His
Thr Leu Asp 225 230 235 240 Gly Gly Arg Ile Gly Ile Ala Ala Gln Ala
Leu Gly Leu Ala Glu Gly 245 250 255 Ala Leu Ala Glu Ala Leu Asn Tyr
Met Lys Glu Arg Lys Gln Phe Gly 260 265 270 Lys Ala Leu Tyr Lys Phe
Gln Gly Leu Ala Trp Met Val Ala Glu Leu 275 280 285 Asp Thr Lys Ile
Glu Ala Val Lys Gln Leu Val Tyr Lys Ala Ala Val 290
295 300 Asn Lys Gln Met Gly Leu Pro Tyr Ser Val Glu Ala Ala Arg Ala
Lys 305 310 315 320 Leu Ala Ala Ala Thr Val Ala Met Glu Thr Thr Thr
Lys Val Val Gln 325 330 335 Ile Phe Gly Gly Tyr Gly Phe Thr Lys Asp
Tyr Pro Val Glu Arg Met 340 345 350 Met Arg Asp Ala Lys Ile Thr Glu
Ile Tyr Glu Gly Thr Ser Gln Val 355 360 365 Gln Lys Met Val Ile Ser
Ala Asn Leu Phe Lys 370 375 62562PRTClostridium kluyveri 62Met Asn
Phe Glu Leu Thr Lys Glu Gln Gln Met Ile Arg Asp Asn Val 1 5 10 15
Arg Lys Phe Ala Glu Ala Lys Ile Glu Pro Ile Ala Phe Gln Leu Asp 20
25 30 Glu Lys Asn Ile Phe Pro Glu Glu Ile Val Asn Glu Met Gly Asp
Leu 35 40 45 Ser Ile Met Gly Leu Pro Tyr Pro Lys Glu Tyr Gly Gly
Ala Gly Lys 50 55 60 Asp Val Leu Ser Tyr Ala Ile Ala Val Glu Glu
Leu Ser Arg Val Asp 65 70 75 80 Ala Gly Val Gly Val Ile Leu Ser Ala
His Thr Ser Leu Gly Thr Trp 85 90 95 Pro Ile Met Glu Phe Gly Thr
Lys Glu Gln Lys Glu Lys Tyr Leu Val 100 105 110 Pro Leu Ala Ser Gly
Lys Lys Ile Ala Ala Phe Gly Leu Thr Glu Pro 115 120 125 Asn Ala Gly
Ser Asp Ala Gly Lys Thr Glu Thr Thr Ala Val Leu Glu 130 135 140 Gly
Asp His Tyr Val Ile Asn Gly Ser Lys Val Phe Ile Thr Asn Ala 145 150
155 160 Asp Tyr Ala Asp Thr Tyr Val Ile Phe Ala Val Thr Thr Pro Gly
Leu 165 170 175 Gly Thr Lys Gly Ile Ser Ala Phe Ile Ile Glu Lys Gly
Met Asp Gly 180 185 190 Phe Thr Phe Gly Thr His Tyr Asn Lys Met Gly
Ile Arg Ser Ser Ala 195 200 205 Thr Ala Glu Leu Leu Phe Lys Asn Leu
Lys Val Pro Lys Tyr Asn Leu 210 215 220 Leu Gly Lys Glu Asn Glu Gly
Phe Lys Ile Ala Met Gln Thr Leu Glu 225 230 235 240 Gly Gly Arg Ile
Gly Ile Ala Ala Gln Ala Leu Gly Ile Ala Gln Gly 245 250 255 Ala Tyr
Glu Lys Ala Leu Ser Tyr Ser Lys Glu Arg Val Gln Phe Gly 260 265 270
Lys Pro Ile Ser Arg Gln Gln Ser Ile Ala Phe Lys Leu Ala Asp Met 275
280 285 Ala Thr Lys Ile Arg Ala Ala Arg Phe Met Val Tyr Ser Ala Ala
Val 290 295 300 Leu Lys Gln Glu His Lys Asn Tyr Gly Met Glu Ser Ala
Met Ala Lys 305 310 315 320 Leu Tyr Ala Ser Asp Ile Cys Leu Glu Val
Val Asn Asp Ala Val Gln 325 330 335 Ile Tyr Gly Gly Ser Gly Phe Ile
Lys Gly Phe Pro Val Glu Arg Met 340 345 350 Tyr Arg Asp Ala Lys Ile
Cys Thr Ile Tyr Glu Gly Thr Asn Glu Ile 355 360 365 Gln Arg Leu Ile
Ile Ser Asn Asp Ile Leu Gly Lys Pro Lys Lys Glu 370 375 380 Pro Ile
Glu Glu Asn Lys Glu Asn Lys Val Asn Lys Ala Lys Pro Ile 385 390 395
400 Thr Gly Asn Arg Arg Arg Val Ile Ile Lys Glu Gly Ser Pro Lys Glu
405 410 415 Lys Val Asp Ala Phe Leu Asn Tyr Ile Lys Ser Glu Asn Ile
Asp Ile 420 425 430 Asn Lys Ser Glu Ala Ser Lys Gly Ser Ile Ala Asp
Ala Asp Lys Val 435 440 445 Cys Ser Ile Gly Leu Gly Leu Lys Asp Lys
Lys Asp Leu Pro Leu Ile 450 455 460 Gln Ser Leu Ala Asp Thr Val Gly
Ala Glu Leu Gly Cys Ser Arg Pro 465 470 475 480 Val Ala Glu Glu Arg
Glu Trp Leu Pro Leu Asp Arg Tyr Val Gly Ile 485 490 495 Ser Gly Gln
Lys Phe Gly Gly Thr Phe Tyr Leu Ala Ile Gly Ile Ser 500 505 510 Gly
Gln Val Gln His Leu Lys Gly Ile Glu Asn Ala Gly Ile Ile Thr 515 520
525 Ala Ile Asn Ile Asp Glu Asp Ala Pro Ile Phe Lys Ser Ser Asp Tyr
530 535 540 Gly Ile Val Gly Asp Leu Tyr Glu Ile Val Pro Leu Leu Ile
Glu Ala 545 550 555 560 Leu Lys 63539PRTEuglena gracilis 63Met Ser
Cys Pro Ala Ser Pro Ser Ala Ala Val Val Ser Ala Gly Ala 1 5 10 15
Leu Cys Leu Cys Val Ala Thr Val Leu Leu Ala Thr Gly Ser Asn Pro 20
25 30 Thr Ala Leu Ser Thr Ala Ser Thr Arg Ser Pro Thr Ser Leu Val
Arg 35 40 45 Gly Val Asp Arg Gly Leu Met Arg Pro Thr Thr Ala Ala
Ala Leu Thr 50 55 60 Thr Met Arg Glu Val Pro Gln Met Ala Glu Gly
Phe Ser Gly Glu Ala 65 70 75 80 Thr Ser Ala Trp Ala Ala Ala Gly Pro
Gln Trp Ala Ala Pro Leu Val 85 90 95 Ala Ala Ala Ser Ser Ala Leu
Ala Leu Trp Trp Trp Ala Ala Arg Arg 100 105 110 Ser Val Arg Arg Pro
Leu Ala Ala Leu Ala Glu Leu Pro Thr Ala Val 115 120 125 Thr His Leu
Ala Pro Pro Met Ala Met Phe Thr Thr Thr Ala Lys Val 130 135 140 Ile
Gln Pro Lys Ile Arg Gly Phe Ile Cys Thr Thr Thr His Pro Ile 145 150
155 160 Gly Cys Glu Lys Arg Val Gln Glu Glu Ile Ala Tyr Ala Arg Ala
His 165 170 175 Pro Pro Thr Ser Pro Gly Pro Lys Arg Val Leu Val Ile
Gly Cys Ser 180 185 190 Thr Gly Tyr Gly Leu Ser Thr Arg Ile Thr Ala
Ala Phe Gly Tyr Gln 195 200 205 Ala Ala Thr Leu Gly Val Phe Leu Ala
Gly Pro Pro Thr Lys Gly Arg 210 215 220 Pro Ala Ala Ala Gly Trp Tyr
Asn Thr Val Ala Phe Glu Lys Ala Ala 225 230 235 240 Leu Glu Ala Gly
Leu Tyr Ala Arg Ser Leu Asn Gly Asp Ala Phe Asp 245 250 255 Ser Thr
Thr Lys Ala Arg Thr Val Glu Ala Ile Lys Arg Asp Leu Gly 260 265 270
Thr Val Asp Leu Val Val Tyr Ser Ile Ala Ala Pro Lys Arg Thr Asp 275
280 285 Pro Ala Thr Gly Val Leu His Lys Ala Cys Leu Lys Pro Ile Gly
Ala 290 295 300 Thr Tyr Thr Asn Arg Thr Val Asn Thr Asp Lys Ala Glu
Val Thr Asp 305 310 315 320 Val Ser Ile Glu Pro Ala Ser Pro Glu Glu
Ile Ala Asp Thr Val Lys 325 330 335 Val Met Gly Gly Glu Asp Trp Glu
Leu Trp Ile Gln Ala Leu Ser Glu 340 345 350 Ala Gly Val Leu Ala Glu
Gly Ala Lys Thr Val Ala Tyr Ser Tyr Ile 355 360 365 Gly Pro Glu Met
Thr Trp Pro Val Tyr Trp Ser Gly Thr Ile Gly Glu 370 375 380 Ala Lys
Lys Asp Val Glu Lys Ala Ala Lys Arg Ile Thr Gln Gln Tyr 385 390 395
400 Gly Cys Pro Ala Tyr Pro Val Val Ala Lys Ala Leu Val Thr Gln Ala
405 410 415 Ser Ser Ala Ile Pro Val Val Pro Leu Tyr Ile Cys Leu Leu
Tyr Arg 420 425 430 Val Met Lys Glu Lys Gly Thr His Glu Gly Cys Ile
Glu Gln Met Val 435 440 445 Arg Leu Leu Thr Thr Lys Leu Tyr Pro Glu
Asn Gly Ala Pro Ile Val 450 455 460 Asp Glu Ala Gly Arg Val Arg Val
Asp Asp Trp Glu Met Ala Glu Asp 465 470 475 480 Val Gln Gln Ala Val
Lys Asp Leu Trp Ser Gln Val Ser Thr Ala Asn 485 490 495 Leu Lys Asp
Ile Ser Asp Phe Ala Gly Tyr Gln Thr Glu Phe Leu Arg 500 505 510 Leu
Phe Gly Phe Gly Ile Asp Gly Val Asp Tyr Asp Gln Pro Val Asp 515 520
525 Val Glu Ala Asp Leu Pro Ser Ala Ala Gln Gln 530 535
64303PRTHomo sapiens 64Met Ala Ser Trp Ala Lys Gly Arg Ser Tyr Leu
Ala Pro Gly Leu Leu 1 5 10 15 Gln Gly Gln Val Ala Ile Val Thr Gly
Gly Ala Thr Gly Ile Gly Lys 20 25 30 Ala Ile Val Lys Glu Leu Leu
Glu Leu Gly Ser Asn Val Val Ile Ala 35 40 45 Ser Arg Lys Leu Glu
Arg Leu Lys Ser Ala Ala Asp Glu Leu Gln Ala 50 55 60 Asn Leu Pro
Pro Thr Lys Gln Ala Arg Val Ile Pro Ile Gln Cys Asn 65 70 75 80 Ile
Arg Asn Glu Glu Glu Val Asn Asn Leu Val Lys Ser Thr Leu Asp 85 90
95 Thr Phe Gly Lys Ile Asn Phe Leu Val Asn Asn Gly Gly Gly Gln Phe
100 105 110 Leu Ser Pro Ala Glu His Ile Ser Ser Lys Gly Trp His Ala
Val Leu 115 120 125 Glu Thr Asn Leu Thr Gly Thr Phe Tyr Met Cys Lys
Ala Val Tyr Ser 130 135 140 Ser Trp Met Lys Glu His Gly Gly Ser Ile
Val Asn Ile Ile Val Pro 145 150 155 160 Thr Lys Ala Gly Phe Pro Leu
Ala Val His Ser Gly Ala Ala Arg Ala 165 170 175 Gly Val Tyr Asn Leu
Thr Lys Ser Leu Ala Leu Glu Trp Ala Cys Ser 180 185 190 Gly Ile Arg
Ile Asn Cys Val Ala Pro Gly Val Ile Tyr Ser Gln Thr 195 200 205 Ala
Val Glu Asn Tyr Gly Ser Trp Gly Gln Ser Phe Phe Glu Gly Ser 210 215
220 Phe Gln Lys Ile Pro Ala Lys Arg Ile Gly Val Pro Glu Glu Val Ser
225 230 235 240 Ser Val Val Cys Phe Leu Leu Ser Pro Ala Ala Ser Phe
Ile Thr Gly 245 250 255 Gln Ser Val Asp Val Asp Gly Gly Arg Ser Leu
Tyr Thr His Ser Tyr 260 265 270 Glu Val Pro Asp His Asp Asn Trp Pro
Lys Gly Ala Gly Asp Leu Ser 275 280 285 Val Val Lys Lys Met Lys Glu
Thr Phe Lys Glu Lys Ala Lys Leu 290 295 300 65303PRTMus musculus
65Met Gly Ser Trp Lys Thr Gly Gln Ser Tyr Leu Ala Ala Gly Leu Leu 1
5 10 15 Lys Asn Gln Val Ala Val Val Thr Gly Gly Gly Thr Gly Ile Gly
Lys 20 25 30 Ala Val Ser Arg Glu Leu Leu His Leu Gly Cys Asn Val
Val Ile Ala 35 40 45 Ser Arg Lys Leu Asp Arg Leu Thr Ala Ala Val
Asp Glu Leu Arg Ala 50 55 60 Ser Leu Pro Pro Ser Ser Ser Ala Glu
Val Ser Ala Ile Gln Cys Asn 65 70 75 80 Ile Arg Lys Glu Glu Glu Val
Ser Asn Leu Val Lys Ser Thr Leu Ala 85 90 95 Lys Tyr Gly Lys Ile
Asn Phe Leu Val Asn Asn Gly Gly Gly Gln Phe 100 105 110 Met Ala Pro
Val Glu Asp Ile Thr Ala Lys Gly Trp His Ala Val Ile 115 120 125 Glu
Thr Asn Leu Thr Gly Thr Phe Tyr Met Cys Lys Glu Val Tyr Asn 130 135
140 Ser Trp Met Arg Glu His Gly Gly Ser Ile Val Asn Ile Ile Val Leu
145 150 155 160 Leu Asn Asn Gly Phe Pro Thr Ala Ala His Thr Gly Ala
Ala Arg Glu 165 170 175 Gly Val Tyr Asn Leu Thr Lys Ser Met Ala Leu
Ala Trp Ala Ser Ser 180 185 190 Gly Val Arg Ile Asn Cys Val Ala Pro
Gly Thr Ile Tyr Ser Gln Thr 195 200 205 Ala Val Asp Asn Tyr Gly Glu
Met Gly Gln Thr Leu Phe Glu Met Ala 210 215 220 Phe Asp Ser Ile Pro
Val Ser Ala Leu Gly Val Pro Glu Glu Ile Ser 225 230 235 240 Leu Leu
Ala Arg Phe Leu Leu Ser Pro Ala Ala Ser Tyr Ile Thr Gly 245 250 255
Gln Leu Ile Asn Val Asp Gly Gly Gln Ala Leu His Thr His Ala Phe 260
265 270 Ser Ile Pro Asp His Asp Asn Trp Pro Val Gly Ala Gly Asp Leu
Ser 275 280 285 Ile Val Lys Arg Ile Lys Glu Ser Phe Lys Lys Lys Ala
Lys Leu 290 295 300 66373PRTRattus norvegicus 66Met Leu Val Ser Arg
Arg Leu Thr Gly Ala Arg Ala Arg Ala Pro Leu 1 5 10 15 Leu Ala Ser
Leu Leu Glu Ala Trp Cys Arg Gln Gly Arg Thr Thr Ser 20 25 30 Ser
Tyr Ser Ala Phe Ser Glu Pro Ser His Val Arg Ala Leu Val Tyr 35 40
45 Gly Asn His Gly Asp Pro Ala Lys Val Ile Gln Leu Lys Asn Leu Glu
50 55 60 Leu Thr Ala Val Glu Gly Ser Asp Val His Val Lys Met Leu
Ala Ala 65 70 75 80 Pro Ile Asn Pro Ser Asp Ile Asn Met Ile Gln Gly
Asn Tyr Gly Leu 85 90 95 Leu Pro Lys Leu Pro Ala Val Gly Gly Asn
Glu Gly Val Gly Gln Val 100 105 110 Ile Ala Val Gly Ser Ser Val Ser
Gly Leu Lys Pro Gly Asp Trp Val 115 120 125 Ile Pro Ala Asn Ala Gly
Leu Gly Thr Trp Arg Thr Glu Ala Val Phe 130 135 140 Ser Glu Glu Ala
Leu Ile Gly Val Pro Lys Asp Ile Pro Leu Gln Ser 145 150 155 160 Ala
Ala Thr Leu Gly Val Asn Pro Cys Thr Ala Tyr Arg Met Leu Val 165 170
175 Asp Phe Glu Gln Leu Gln Pro Gly Asp Ser Val Ile Gln Asn Ala Ser
180 185 190 Asn Ser Gly Val Gly Gln Ala Val Ile Gln Ile Ala Ser Ala
Leu Gly 195 200 205 Leu Lys Thr Ile Asn Val Ile Arg Asp Arg Pro Asp
Ile Lys Lys Leu 210 215 220 Thr Asp Arg Leu Lys Asp Leu Gly Ala Asp
Tyr Val Leu Thr Glu Glu 225 230 235 240 Glu Leu Arg Met Pro Glu Thr
Lys Asn Ile Phe Lys Asp Leu Pro Leu 245 250 255 Pro Arg Leu Ala Leu
Asn Cys Val Gly Gly Lys Ser Ser Thr Glu Leu 260 265 270 Leu Arg His
Leu Ala Pro Gly Gly Thr Met Val Thr Tyr Gly Gly Met 275 280 285 Ala
Lys Gln Pro Val Thr Ala Ser Val Ser Met Leu Ile Phe Lys Asp 290 295
300 Leu Lys Leu Arg Gly Phe Trp Leu Ser Gln Trp Lys Lys Asn His Ser
305 310 315 320 Pro Asp Glu Phe Lys Glu Leu Ile Leu Ile Leu Cys Asn
Leu Ile Arg 325 330 335 Gln Gly Gln Leu Thr Ala Pro Ala Trp Ser Gly
Ile Pro Leu Gln Asp 340 345 350 Tyr Gln Gln Ala Leu Glu Ala Ser Met
Lys Pro Phe Val Ser Leu Lys 355 360 365 Gln Ile Leu Thr Met 370
67380PRTSaccharomyces cerevisiae 67Met Leu Pro Thr Phe Lys Arg Tyr
Met Ser Ser Ser Ala His Gln Ile 1 5 10 15 Pro Lys His Phe Lys Ser
Leu Ile Tyr Ser Thr His Glu Val Glu Asp 20 25 30 Cys Thr Lys Val
Leu Ser Val Lys Asn Tyr Thr Pro Lys Gln Asp Leu 35 40 45 Ser Gln
Ser Ile Val Leu Lys Thr Leu Ala Phe Pro Ile Asn Pro Ser 50 55 60
Asp Ile Asn Gln Leu Gln Gly Val Tyr Pro Ser Arg Pro Glu Lys Thr 65
70 75 80 Tyr Asp Tyr Ser Thr Asp Glu Pro Ala Ala Ile Ala Gly Asn
Glu Gly 85 90 95 Val Phe Glu Val Val Ser Leu Pro Ser Gly Ser Ser
Lys Gly Asp Leu 100 105 110 Lys Leu Gly Asp Arg Val Ile Pro Leu Gln
Ala Asn Gln Gly Thr Trp 115
120 125 Ser Asn Tyr Arg Val Phe Ser Ser Ser Ser Asp Leu Ile Lys Val
Asn 130 135 140 Asp Leu Asp Leu Phe Ser Ala Ala Thr Val Ser Val Asn
Gly Cys Thr 145 150 155 160 Gly Phe Gln Leu Val Ser Asp Tyr Ile Asp
Trp Asn Ser Asn Gly Asn 165 170 175 Glu Trp Ile Ile Gln Asn Ala Gly
Thr Ser Ser Val Ser Lys Ile Val 180 185 190 Thr Gln Val Ala Lys Ala
Lys Gly Ile Lys Thr Leu Ser Val Ile Arg 195 200 205 Asp Arg Asp Asn
Phe Asp Glu Val Ala Lys Val Leu Glu Asp Lys Tyr 210 215 220 Gly Ala
Thr Lys Val Ile Ser Glu Ser Gln Asn Asn Asp Lys Thr Phe 225 230 235
240 Ala Lys Glu Val Leu Ser Lys Ile Leu Gly Glu Asn Ala Arg Val Arg
245 250 255 Leu Ala Leu Asn Ser Val Gly Gly Lys Ser Ser Ala Ser Ile
Ala Arg 260 265 270 Lys Leu Glu Asn Asn Ala Leu Met Leu Thr Tyr Gly
Gly Met Ser Lys 275 280 285 Gln Pro Val Thr Leu Pro Thr Ser Leu His
Ile Phe Lys Gly Leu Thr 290 295 300 Ser Lys Gly Tyr Trp Val Thr Glu
Lys Asn Lys Lys Asn Pro Gln Ser 305 310 315 320 Lys Ile Asp Thr Ile
Ser Asp Phe Ile Lys Met Tyr Asn Tyr Gly His 325 330 335 Ile Ile Ser
Pro Arg Asp Glu Ile Glu Thr Leu Thr Trp Asn Thr Asn 340 345 350 Thr
Thr Thr Asp Glu Gln Leu Leu Glu Leu Val Lys Lys Gly Ile Thr 355 360
365 Gly Lys Gly Lys Lys Lys Met Val Val Leu Glu Trp 370 375 380
68365PRTPenicillium Chrysogenum 68Met Ser Lys Arg Val Thr Ile Phe
Asp Pro Pro Glu Gln Asp His Ser 1 5 10 15 Lys Ala Leu Ile Glu Asn
Val Leu Asp Leu Thr Pro Val Val Asp Leu 20 25 30 Gly Pro Asp Val
Phe Thr Asn Thr Arg Pro Leu Trp His Pro Pro Gly 35 40 45 Ala Arg
Gly Ile Tyr Gly Gly Ala Ala Ile Ala Gln Ser Leu Ser Ala 50 55 60
Ala Met Arg Thr Val Pro Ala Asp Tyr Ala Val His Ser Met His Cys 65
70 75 80 Tyr Phe Val Leu Ala Gly Asp Ser Glu Ile Pro Ile Leu Tyr
His Val 85 90 95 Glu Arg Val Arg Asp Gly Arg Ser Phe Val Thr Arg
Thr Val Gln Ala 100 105 110 Arg Gln Arg Gly Arg Pro Ile Phe Thr Thr
Thr Leu Ser Phe Ser Arg 115 120 125 Val Gly Ser Gly Gly Glu Lys Thr
Leu His His Ala Val Ser Lys Pro 130 135 140 Asp Val Pro Leu Pro Glu
Glu Ala Glu Pro Gly Ser Leu Lys Ala Leu 145 150 155 160 Ser Asn Ala
Gly Gly Gly Pro Phe Glu Ser Arg Lys Ala Gly Ile Leu 165 170 175 Asn
Arg Thr Ser Pro Asn Pro Glu Asp Lys Lys Val Arg Arg Tyr Ile 180 185
190 Arg Ala Arg Gly Ala Ile Ser Glu Glu Gly Gly Tyr Gln Ala His Leu
195 200 205 Ser Ala Leu Ala Tyr Ile Thr Asp Ser Tyr Phe Ile Gly Thr
Val Ser 210 215 220 Ile Val His Asp Val Pro Arg Phe Ser Ser Pro Ala
Glu Leu Glu Lys 225 230 235 240 Leu Leu Asn Ala Leu Lys Asn Pro Ser
Asp Leu Asp Asp Glu Asp Ile 245 250 255 Thr Arg Ala Leu Arg Glu Leu
Lys Glu Glu Glu Ala Ala Glu Leu Arg 260 265 270 Arg Arg Leu Glu Gly
Ala Leu Asn Arg Ala Thr Gly Pro Lys Glu Val 275 280 285 Asp His Lys
Glu Val Gly Met Met Val Ser Leu Asp His Ser Ile Tyr 290 295 300 Phe
His Asn Pro Arg Ala Phe Arg Ala Asp Glu Trp Met Leu Ser Glu 305 310
315 320 Ile Glu Ser Pro Trp Ala Gly Glu Gly Arg Gly Leu Ala Ile Gln
Lys 325 330 335 Leu Trp Ser Lys Asp Gly Val Leu Ile Ala Thr Cys Thr
Gln Glu Val 340 345 350 Cys Ile Cys Phe Tyr Ser Leu Tyr Ser Gly Gly
Gln Cys 355 360 365 69525PRTPenicillium Chrysogenum 69Met Ser Ala
Ser Ala Leu Leu Lys Ser Arg Val Arg Arg Pro Ser Tyr 1 5 10 15 Leu
Lys Lys Leu Ala Lys Pro Glu Asp Leu Leu His His Phe Pro Asn 20 25
30 Gly Thr Tyr Ile Gly Trp Ser Gly Phe Thr Gly Val Gly Tyr Pro Lys
35 40 45 Met Thr Pro Ile Ala Leu Ala Asp His Val Glu Lys Asn Asn
Leu Gln 50 55 60 Gly Gln Leu Lys Tyr Asn Leu Phe Val Gly Ala Ser
Ser Gly Ala Glu 65 70 75 80 Thr Glu Asn Arg Trp Ala Arg Leu Asn Met
Ile Glu Arg Arg Ser Pro 85 90 95 His Gln Val Gly Lys Glu Ile Ala
Lys Gly Ile Asn Asn Gly Gln Ile 100 105 110 Lys Phe Phe Asp Lys His
Leu Ser Met Phe Pro Ser Asp Leu Val Tyr 115 120 125 Gly Tyr Tyr Thr
Leu Asn Lys Ser Lys Pro Thr Ile Asp Val Ala Val 130 135 140 Ile Glu
Ala Ser Ala Ile Thr Glu Asn Gly Gly Ile Ile Pro Gly Ala 145 150 155
160 Ser Val Gly Ala Ser Pro Glu Leu Ile Gln Met Ala Asp Lys Val Ile
165 170 175 Ile Glu Val Asn Thr Ser Met Pro Ser Phe Glu Gly Leu His
Asp Ile 180 185 190 Thr Cys Ser Asp Leu Pro Pro Gly Arg Lys Pro Tyr
Leu Ile Met Ala 195 200 205 Pro Glu Asp Arg Ile Gly Thr Ser Tyr Ile
Pro Ile Asp Pro Glu Lys 210 215 220 Val Val Ala Ile Val Glu Ser Asn
Tyr Pro Asp Gln Thr Leu Pro Asn 225 230 235 240 Ala Pro Glu Asp Glu
Gly Ser Gln Ala Ile Ala Ser Asn Leu Ile Glu 245 250 255 Phe Leu Lys
His Glu Val Asn His Gly Arg Leu Pro Pro Asn Leu Leu 260 265 270 Pro
Ile Gln Ser Gly Ile Gly Asn Ile Ala Asn Ala Val Val Gly Gly 275 280
285 Leu Ser Lys Gly Gly Ala Asp Phe Lys Asn Leu Lys Val Trp Thr Glu
290 295 300 Val Leu Gln Asp Ser Phe Leu Asp Leu Phe Asp Ser Gly Asn
Leu Asp 305 310 315 320 Phe Ala Thr Ala Thr Ser Ile Arg Phe Ser Pro
Asp Gly Phe Lys Arg 325 330 335 Phe Tyr Asp Asn Trp Glu Gln Tyr Ala
Gly Lys Leu Leu Leu Arg Ser 340 345 350 Gln Gln Val Ser Asn Ser Pro
Glu Ile Ile Arg Arg Leu Gly Cys Ile 355 360 365 Gly Met Asn Thr Pro
Val Glu Val Asp Ile Tyr Ala His Ala Asn Ser 370 375 380 Thr Cys Val
Met Gly Ser Arg Met Leu Asn Gly Leu Gly Gly Ser Ala 385 390 395 400
Asp Phe Leu Arg Asn Ser Lys Tyr Ser Ile Met His Thr Pro Ser Ala 405
410 415 Arg Pro Thr Lys Thr Asp Pro Thr Gly Val Ser Cys Ile Val Pro
Phe 420 425 430 Ala Thr His Ile Asp Gln Thr Glu His Asp Leu Asp Val
Val Val Thr 435 440 445 Glu Gln Gly Leu Ala Asp Val Arg Gly Leu Ser
Pro Arg Glu Arg Ala 450 455 460 Arg Val Ile Ile Lys Asn Cys Ser His
Pro Asp Tyr Thr Pro Ile Leu 465 470 475 480 Thr Asp Tyr Leu Asp Arg
Ala Glu Phe Glu Cys Leu Arg Lys Gly Met 485 490 495 Gly His Glu Pro
His Met Leu Phe Gln Ala Phe Asn Met His Lys Asn 500 505 510 Leu Gln
Glu Lys Gly Thr Met Lys Ile Asp Ser Trp Glu 515 520 525
70253PRTPenicillium Chrysogenum 70Met Asp Lys Tyr Thr Ile Pro Leu
Glu Lys Ala Val Glu Leu Thr Pro 1 5 10 15 Ile Pro Ser Glu Pro Asp
Thr Phe Thr Asn Ala Gln Pro Leu Trp Ser 20 25 30 Phe Ala Gly Gly
Tyr Gly Val Tyr Gly Gly Ser Thr Val Ala His Cys 35 40 45 Leu Val
Ala Ala Gln Lys Thr Val Pro Cys Asp Tyr Val Ala His Ser 50 55 60
Leu His Cys Gly Phe Val Ser Pro Gly Asn Pro Lys Arg Pro Ile Glu 65
70 75 80 Tyr Arg Val Glu Arg Thr Arg Asp Gly Lys Ser Phe Ile Thr
Arg Thr 85 90 95 Val His Ala Thr Gln Lys Ala Gly Val Ile Ser Glu
Ala Ile Val Asn 100 105 110 Phe Val Arg Val Gly Thr Tyr Ser Asn Asn
Ala Ser His Asp Leu Val 115 120 125 Asn Thr Gln Ile Arg Tyr Trp Val
Arg Ala Lys Asp Pro Ile Gln Gln 130 135 140 Arg Ser Pro Gln Ala Gln
Leu Ala Ala Leu Ala Tyr Met Ser Asp Ala 145 150 155 160 Tyr Leu Ile
Gly Ala Ala Val Gln Val His Asp Val Ala Gly Gln Ala 165 170 175 Phe
Gly Thr Lys Met Ala Met Ala Ala Ser Leu Asn His Thr Ile Tyr 180 185
190 Phe His Asn Pro Glu Ala Val Arg Ala Asp Glu Trp Met Cys Ser Glu
195 200 205 Arg Glu Ser Pro Trp Ala Gly Asn Asp Arg Ala Leu Val Val
Gln Arg 210 215 220 Val Trp Ser Pro Glu Gly Ile Leu Val Ala Thr Cys
Val Gln Glu Gly 225 230 235 240 Val Leu Arg Val Gln Val Pro Ser Glu
Lys Val Lys Leu 245 250 71462PRTPenicillium Chrysogenum 71Met Phe
Gly Leu Ser Arg Arg Ser Ala Leu Ala Arg Ser Lys Ser Leu 1 5 10 15
Ala Ala Leu Pro Ala Arg Ala Ala Val Ala Ala Gln Pro Ser Cys Ile 20
25 30 Asn Thr Gln Gly Phe His Ser Thr Pro Ser Gln Ala Ala Ser Arg
Pro 35 40 45 Thr Trp Met Pro Met Arg Val Lys Thr Pro Trp Ile Glu
Ala Leu Thr 50 55 60 Gln Ile Arg Glu Ala Gln Lys Ala Gly Pro Gln
Glu Asn Ala Gly Gln 65 70 75 80 Ser Val Lys Arg Asp Leu Ser Pro Lys
Lys Met Ser Asp Ser Tyr Tyr 85 90 95 Ser Ala Ile Leu Pro Leu Ala
Gln Asp Lys Trp Leu Leu Asp Ser Tyr 100 105 110 Leu Asn Ala Ser Gly
His Ile Arg Leu Gly Ser Leu Leu Met Asp Leu 115 120 125 Asp Ala Leu
Ala Gly Ile Val Ala Tyr Arg His Thr Gly Asp Gly Val 130 135 140 Ser
Thr Val Thr Ala Ala Cys Asp Arg Ile Thr Ile Glu Asn Pro Leu 145 150
155 160 Met Glu Ile Cys Asp Leu Glu Leu Ser Gly Gln Cys Thr Tyr Ala
Thr 165 170 175 Gly Arg Ser Ser Met Glu Ile Ser Leu Gln Val Thr Lys
Ala Arg Pro 180 185 190 Glu Gly Gln Glu Ala Lys Pro Glu Asp Ile Leu
Ile Thr Cys Ala Phe 195 200 205 Thr Met Val Ser Leu Asp Pro Ala Thr
Lys Ala Pro Val Pro Val Ala 210 215 220 Pro Leu Ile Val Glu Thr Glu
Glu Glu Lys Arg Leu Phe Gln Lys Gly 225 230 235 240 Glu Ala Asn Tyr
Gln Ala Lys Lys Ala Leu Arg Thr Arg Ser Leu Leu 245 250 255 Gln Lys
Ser Pro Asp Asp Glu Glu Ser Asn Leu Ile His Ser Met Trp 260 265 270
Thr Lys Glu Met Ser Tyr Leu Asn Pro Gln Asn Pro Ala Thr Arg Pro 275
280 285 Ala Asn Gln Val Phe Met Ser Asp Thr Val Leu Lys Ser Ala Met
Ile 290 295 300 Met Gln Pro Gln Asp Arg Asn Arg His Asn Phe Met Ile
Phe Gly Gly 305 310 315 320 Phe Leu Leu Lys Gln Thr Phe Glu Leu Ala
Phe Cys Cys Ala Ala Ser 325 330 335 Phe Ala His Ala Arg Pro Asn Phe
Val Ala Leu Asp Pro Ser Thr Phe 340 345 350 Glu Asn Pro Val Pro Val
Gly Ser Val Leu Tyr Leu Arg Ala Thr Val 355 360 365 Ser Tyr Thr Glu
Pro Glu Glu Arg Glu Gly Asp Ser Thr Lys Tyr Thr 370 375 380 Lys Val
Gln Val Arg Val Asp Ser Lys Val Arg Asp Val Glu His Gly 385 390 395
400 Thr Lys Lys Ser Thr Gly Met Phe Asn Tyr Thr Phe Leu Val Glu Lys
405 410 415 Asp Val Gln Val Met Pro Lys Gly Tyr Gly Glu Phe Met Leu
Trp Ala 420 425 430 Asp Ala Arg Arg Arg Ala Gln Asn Ala Ala Ala Ile
Asp Pro Ala His 435 440 445 Lys Met Ser Ala Leu Arg Ser Ile Lys Asp
Ser Val Thr Glu 450 455 460 72357PRTPenicillium Chrysogenum 72Met
Ser Pro Gln Arg Gly Ala Pro Asp Asn Asp Asp Leu Thr Ser Pro 1 5 10
15 His Ser Phe Val Glu Leu Met Ser Leu Gln Arg Leu Glu Asp Ala Leu
20 25 30 Ile Thr Tyr Pro Asp Ser Ala Lys Pro Glu Lys Ile Glu Arg
Phe Arg 35 40 45 Ser Leu Ala Thr Pro Tyr Asn Pro Gly Gln Gly Thr
Arg Ser Phe Gly 50 55 60 Gly His Val Tyr Ala Gln Ser Ala Tyr Ala
Ala Ser Lys Thr Val Gly 65 70 75 80 Pro Gly Leu Val Ile His Asp Met
Thr Gly Thr Phe Ile Leu Gly Gly 85 90 95 Leu Leu Asp Thr Pro Tyr
Val Tyr Thr Val Arg His Ile Arg Asp Gly 100 105 110 Tyr Met Tyr Ser
Thr Arg Ala Val Asp Ala Arg Gln Ala Gly Arg Ile 115 120 125 Cys Phe
Ser Cys Ile Cys Ser Phe Lys Arg Asp Glu Lys Gln Arg Leu 130 135 140
Phe Gln His Gln Pro Ala Ser Ala Gln Ala Arg Phe Asp Ser Ile Leu 145
150 155 160 Ser Ala Lys Arg Pro Glu Asp Gln Glu Pro Ser Pro Ser Val
Asp Ala 165 170 175 Glu Trp Trp Ile Glu Ala Val Arg Gln Gly Asn Ile
Ser Glu Ser Glu 180 185 190 Phe Pro Gly Leu Asp Val Arg Lys Thr Asp
Met Lys Asp Tyr Asn Cys 195 200 205 Ala Glu Asp Val Lys Gln His Pro
Glu Arg Tyr Arg Gln Leu Thr Gln 210 215 220 Tyr Arg Leu Lys Gly Ser
Pro Glu Glu Asp Pro Ala Ala Ser Leu Ala 225 230 235 240 Gln Ile Arg
Glu Arg Glu Glu Asn Gly Glu Tyr Asp Asn Leu Tyr Ala 245 250 255 Cys
Ala His Met Tyr Ser Ser Asp Lys Asn Ser Leu Leu Leu Ile Pro 260 265
270 Arg Ala Leu Gly Ile Lys Asn Trp Thr Glu Met Ala Ser Leu Thr Leu
275 280 285 Thr Val Ile Val His Gln His Gly Glu Ala Leu Arg Met Val
Asn Trp 290 295 300 Asp Ser Ile Gly Asp Ser Asp Val Gly Val Asp Lys
Leu Pro Met Lys 305 310 315 320 Trp Phe Val Gln Glu Gly Trp Thr Pro
Arg Ala Thr Glu Asn Arg Gly 325 330 335 Thr His Glu Ser His Leu Trp
Ser Pro Asp Gly Thr Leu Leu Ala Thr 340 345 350 Ser Leu Gln Asp Asn
355 73320PRTMus musculus 73Met Ser Ala Pro Glu Gly Leu Gly Asp Ala
His Gly Asp Ala Asp Arg 1 5 10 15 Gly Asp Leu Ser Gly Asp Leu Arg
Ser Val Leu Val Thr Ser Val Leu 20 25 30 Asn Leu Glu Pro Leu Asp
Glu Asp Leu Tyr Arg Gly Arg His Tyr Trp 35 40 45 Val Pro Thr Ser
Gln Arg Leu Phe Gly Gly Gln Ile Met Gly Gln Ala 50
55 60 Leu Val Ala Ala Ala Lys Ser Val Ser Glu Asp Val His Val His
Ser 65 70 75 80 Leu His Cys Tyr Phe Val Arg Ala Gly Asp Pro Lys Val
Pro Val Leu 85 90 95 Tyr His Val Glu Arg Ile Arg Thr Gly Ala Ser
Phe Ser Val Arg Ala 100 105 110 Val Lys Ala Val Gln His Gly Lys Ala
Ile Phe Ile Cys Gln Ala Ser 115 120 125 Phe Gln Gln Met Gln Pro Ser
Pro Leu Gln His Gln Phe Ser Met Pro 130 135 140 Ser Val Pro Pro Pro
Glu Asp Leu Leu Asp His Glu Ala Leu Ile Asp 145 150 155 160 Gln Tyr
Leu Arg Asp Pro Asn Leu His Lys Lys Tyr Arg Val Gly Leu 165 170 175
Asn Arg Val Ala Ala Gln Glu Val Pro Ile Glu Ile Lys Val Val Asn 180
185 190 Pro Pro Thr Leu Thr Gln Leu Gln Ala Leu Glu Pro Lys Gln Met
Phe 195 200 205 Trp Val Arg Ala Arg Gly Tyr Ile Gly Glu Gly Asp Ile
Lys Met His 210 215 220 Cys Cys Val Ala Ala Tyr Ile Ser Asp Tyr Ala
Phe Leu Gly Thr Ala 225 230 235 240 Leu Leu Pro His Gln Ser Lys Tyr
Lys Val Asn Phe Met Ala Ser Leu 245 250 255 Asp His Ser Met Trp Phe
His Ala Pro Phe Arg Ala Asp His Trp Met 260 265 270 Leu Tyr Glu Cys
Glu Ser Pro Trp Ala Gly Gly Phe Arg Gly Leu Val 275 280 285 His Gly
Arg Leu Trp Arg Arg Asp Gly Val Leu Ala Val Thr Cys Ala 290 295 300
Gln Glu Gly Val Ile Arg Leu Lys Pro Gln Val Ser Glu Ser Lys Leu 305
310 315 320 74472PRTClostridium kluyveri 74Met Ser Asn Glu Val Ser
Ile Lys Glu Leu Ile Glu Lys Ala Lys Ala 1 5 10 15 Ala Gln Lys Lys
Leu Glu Ala Tyr Ser Gln Glu Gln Val Asp Val Leu 20 25 30 Val Lys
Ala Leu Gly Lys Val Val Tyr Asp Asn Ala Glu Met Phe Ala 35 40 45
Lys Glu Ala Val Glu Glu Thr Glu Met Gly Val Tyr Glu Asp Lys Val 50
55 60 Ala Lys Cys His Leu Lys Ser Gly Ala Ile Trp Asn His Ile Lys
Asp 65 70 75 80 Lys Lys Thr Val Gly Ile Ile Lys Glu Glu Pro Glu Arg
Ala Leu Val 85 90 95 Tyr Val Ala Lys Pro Lys Gly Val Val Ala Ala
Thr Thr Pro Ile Thr 100 105 110 Asn Pro Val Val Thr Pro Met Cys Asn
Ala Met Ala Ala Ile Lys Gly 115 120 125 Arg Asn Thr Ile Ile Val Ala
Pro His Pro Lys Ala Lys Lys Val Ser 130 135 140 Ala His Thr Val Glu
Leu Met Asn Ala Glu Leu Lys Lys Leu Gly Ala 145 150 155 160 Pro Glu
Asn Ile Ile Gln Ile Val Glu Ala Pro Ser Arg Glu Ala Ala 165 170 175
Lys Glu Leu Met Glu Ser Ala Asp Val Val Ile Ala Thr Gly Gly Ala 180
185 190 Gly Arg Val Lys Ala Ala Tyr Ser Ser Gly Arg Pro Ala Tyr Gly
Val 195 200 205 Gly Pro Gly Asn Ser Gln Val Ile Val Asp Lys Gly Tyr
Asp Tyr Asn 210 215 220 Lys Ala Ala Gln Asp Ile Ile Thr Gly Arg Lys
Tyr Asp Asn Gly Ile 225 230 235 240 Ile Cys Ser Ser Glu Gln Ser Val
Ile Ala Pro Ala Glu Asp Tyr Asp 245 250 255 Lys Val Ile Ala Ala Phe
Val Glu Asn Gly Ala Phe Tyr Val Glu Asp 260 265 270 Glu Glu Thr Val
Glu Lys Phe Arg Ser Thr Leu Phe Lys Asp Gly Lys 275 280 285 Ile Asn
Ser Lys Ile Ile Gly Lys Ser Val Gln Ile Ile Ala Asp Leu 290 295 300
Ala Gly Val Lys Val Pro Glu Gly Thr Lys Val Ile Val Leu Lys Gly 305
310 315 320 Lys Gly Ala Gly Glu Lys Asp Val Leu Cys Lys Glu Lys Met
Cys Pro 325 330 335 Val Leu Val Ala Leu Lys Tyr Asp Thr Phe Glu Glu
Ala Val Glu Ile 340 345 350 Ala Met Ala Asn Tyr Met Tyr Glu Gly Ala
Gly His Thr Ala Gly Ile 355 360 365 His Ser Asp Asn Asp Glu Asn Ile
Arg Tyr Ala Arg Thr Val Leu Pro 370 375 380 Ile Ser Arg Leu Val Val
Asn Gln Pro Ala Thr Thr Ala Gly Gly Thr 385 390 395 400 Val Leu Pro
Ile Ser Arg Leu Val Val Asn Gln Pro Ala Thr Thr Ala 405 410 415 Gly
Gly Ser Phe Asn Asn Gly Phe Asn Pro Thr Thr Thr Leu Gly Cys 420 425
430 Gly Ser Trp Gly Arg Asn Ser Ile Ser Glu Asn Leu Thr Tyr Glu His
435 440 445 Leu Ile Asn Val Ser Arg Ile Gly Tyr Phe Asn Lys Glu Ala
Lys Val 450 455 460 Pro Ser Tyr Glu Glu Ile Trp Gly 465 470
75451PRTPorphyromonas gingivalis 75Met Glu Ile Lys Glu Met Val Ser
Leu Ala Arg Lys Ala Gln Lys Glu 1 5 10 15 Tyr Gln Ala Thr His Asn
Gln Glu Ala Val Asp Asn Ile Cys Arg Ala 20 25 30 Ala Ala Lys Val
Ile Tyr Glu Asn Ala Ala Ile Leu Ala Arg Glu Ala 35 40 45 Val Asp
Glu Thr Gly Met Gly Val Tyr Glu His Lys Val Ala Lys Asn 50 55 60
Gln Gly Lys Ser Lys Gly Val Trp Tyr Asn Leu His Asn Lys Lys Ser 65
70 75 80 Ile Gly Ile Leu Asn Ile Asp Glu Arg Thr Gly Met Ile Glu
Ile Ala 85 90 95 Lys Pro Ile Gly Val Val Gly Ala Val Thr Pro Thr
Thr Asn Pro Ile 100 105 110 Val Thr Pro Met Ser Asn Ile Ile Phe Ala
Leu Lys Thr Cys Asn Ala 115 120 125 Ile Ile Ile Ala Pro His Pro Arg
Ser Lys Lys Cys Ser Ala His Ala 130 135 140 Val Arg Leu Ile Lys Glu
Ala Ile Ala Pro Phe Asn Val Pro Glu Gly 145 150 155 160 Met Val Gln
Ile Ile Glu Glu Pro Ser Ile Glu Lys Thr Gln Glu Leu 165 170 175 Met
Gly Ala Val Asp Val Val Val Ala Thr Gly Gly Met Gly Met Val 180 185
190 Lys Ser Ala Tyr Ser Ser Gly Lys Pro Ser Phe Gly Val Gly Ala Gly
195 200 205 Asn Val Gln Val Ile Val Asp Ser Asn Ile Asp Phe Glu Ala
Ala Ala 210 215 220 Glu Lys Ile Ile Thr Gly Arg Ala Phe Asp Asn Gly
Ile Ile Cys Ser 225 230 235 240 Gly Glu Gln Ser Ile Ile Tyr Asn Glu
Ala Asp Lys Glu Ala Val Phe 245 250 255 Thr Ala Phe Arg Asn His Gly
Ala Tyr Phe Cys Asp Glu Ala Glu Gly 260 265 270 Asp Arg Ala Arg Ala
Ala Ile Phe Glu Asn Gly Ala Ile Ala Lys Asp 275 280 285 Val Val Gly
Gln Ser Val Ala Phe Ile Ala Lys Lys Ala Asn Ile Asn 290 295 300 Ile
Pro Glu Gly Thr Arg Ile Leu Val Val Glu Ala Arg Gly Val Gly 305 310
315 320 Ala Glu Asp Val Ile Cys Lys Glu Lys Met Cys Pro Val Met Cys
Ala 325 330 335 Leu Ser Tyr Lys His Phe Glu Glu Gly Val Glu Ile Ala
Arg Thr Asn 340 345 350 Leu Ala Asn Glu Gly Asn Gly His Thr Cys Ala
Ile His Ser Asn Asn 355 360 365 Gln Ala His Ile Ile Leu Ala Gly Ser
Glu Leu Thr Val Ser Arg Ile 370 375 380 Val Val Asn Ala Pro Ser Ala
Thr Thr Ala Gly Gly His Ile Gln Asn 385 390 395 400 Gly Leu Ala Val
Thr Asn Thr Leu Gly Cys Gly Ser Trp Gly Asn Asn 405 410 415 Ser Ile
Ser Glu Asn Phe Thr Tyr Lys His Leu Leu Asn Ile Ser Arg 420 425 430
Ile Ala Pro Leu Asn Ser Ser Ile His Ile Pro Asp Asp Lys Glu Ile 435
440 445 Trp Glu Leu 450 76876PRTClostridium kluyveri 76Met Lys Val
Thr Asn Val Glu Glu Leu Met Lys Lys Leu Gln Lys Val 1 5 10 15 Arg
Gln Ala Gln Glu Lys Phe Ser Thr Tyr Thr Gln Glu Gln Val Asp 20 25
30 Glu Ile Phe Lys Gln Ala Ala Met Ala Ala Asn Ser Ala Arg Ile Lys
35 40 45 Leu Ala Lys Met Ala Val Glu Glu Thr Gly Met Gly Ile Val
Glu Asp 50 55 60 Lys Val Ile Lys Asn His Phe Val Ser Glu Tyr Val
Tyr Asn Lys Tyr 65 70 75 80 Lys Asp Glu Gln Thr Cys Gly Val Leu Glu
Arg Asp Glu Gly Phe Gly 85 90 95 Met Val Arg Ile Ala Glu Pro Val
Gly Val Ile Ala Ala Val Val Pro 100 105 110 Thr Thr Asn Pro Thr Ser
Thr Ala Ile Phe Lys Ala Leu Ile Ala Leu 115 120 125 Lys Thr Arg Asn
Gly Ile Val Phe Ser Pro His Pro Arg Ala Lys Arg 130 135 140 Ser Thr
Val Ala Ala Ala Lys Ile Val Leu Asp Ala Ala Val Glu Ala 145 150 155
160 Gly Ala Pro Val Glu Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile Glu
165 170 175 Leu Ser Gln Leu Val Met Lys Glu Ala Asp Leu Ile Leu Ala
Thr Gly 180 185 190 Gly Pro Gly Met Val Arg Ala Ala Tyr Ser Ser Gly
Lys Pro Ala Ile 195 200 205 Gly Val Gly Pro Gly Asn Thr Pro Val Ile
Ile Asp Asp Ser Ala Asn 210 215 220 Ile Lys Met Ala Val Asn Ser Ile
Leu Leu Ser Lys Ser Phe Asp His 225 230 235 240 Gly Val Ile Cys Ala
Ser Glu Gln Ser Val Met Val Leu Asp Arg Ile 245 250 255 Tyr Glu Glu
Val Lys Thr Glu Phe Ser Glu Arg Gly Gly Tyr Ile Leu 260 265 270 Lys
Asn Asp Glu Ile Asp Lys Val Arg Glu Thr Ile Leu Val Asn Gly 275 280
285 Ser Ile Ser Pro Asp Ile Val Gly Gln Ser Ala Arg Lys Ile Ala Glu
290 295 300 Met Ala Gly Val Lys Val Pro Glu Arg Thr Lys Ile Leu Ile
Gly Glu 305 310 315 320 Val Glu Ser Val Glu Leu Glu Glu Pro Phe Ser
Arg Glu Lys Leu Ser 325 330 335 Pro Val Leu Ala Met Tyr Arg Val Lys
Asn Phe Asn Asp Gly Leu Lys 340 345 350 Lys Ala Ala Arg Leu Val Glu
Leu Gly Gly Ile Gly His Thr Ser Val 355 360 365 Leu Tyr Val Asn Thr
Met Thr Gln Lys Glu Lys Val Glu Lys Phe Ser 370 375 380 Glu Ala Met
Lys Thr Gly Arg Thr Leu Ile Asn Met Pro Ser Ala Gln 385 390 395 400
Gly Ala Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser Leu Thr 405
410 415 Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn Val
Gly 420 425 430 Pro Lys His Leu Leu Asn Ile Lys Ser Ile Ala Glu Arg
Arg Glu Asn 435 440 445 Met Leu Trp Phe Arg Val Pro Glu Lys Ile Tyr
Phe Lys Tyr Gly Ala 450 455 460 Leu Gly Thr Ala Leu Lys Glu Leu Lys
Thr Met His Lys Lys Lys Val 465 470 475 480 Phe Ile Val Thr Asp Lys
Val Leu Tyr Gln Leu Gly Tyr Thr Asp Ser 485 490 495 Ile Thr Lys Ile
Leu Gly Glu Met Gly Val Gly Tyr Lys Ile Phe Thr 500 505 510 Asp Val
Glu Pro Asp Pro Thr Leu Ala Thr Ala Lys Lys Gly Ser Ala 515 520 525
Glu Met Leu Gln Tyr Asn Pro Asp Thr Ile Ile Ser Val Gly Gly Gly 530
535 540 Ser Ala Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu His
Pro 545 550 555 560 Glu Ile Lys Phe Glu Asp Leu Ala Met Arg Phe Met
Asp Ile Arg Lys 565 570 575 Arg Val Tyr Thr Phe Pro Lys Met Gly Glu
Lys Ser Met Met Ile Ser 580 585 590 Val Ala Thr Ser Ala Gly Thr Gly
Ser Glu Val Thr Pro Phe Thr Val 595 600 605 Ile Thr Asp Glu Lys Thr
Gly Ala Lys Tyr Pro Leu Ala Asp Tyr Glu 610 615 620 Leu Thr Pro Asp
Ile Ala Ile Ile Asp Ala Glu Leu Met Met Asn Met 625 630 635 640 Pro
Lys Gly Leu Thr Ala Ala Ser Gly Ile Asp Ala Met Thr His Ala 645 650
655 Leu Glu Ser Tyr Val Ser Val Met Ala Ser Glu Tyr Thr Asn Gly Leu
660 665 670 Ala Leu Glu Ala Ile Arg Leu Ile Phe Lys Tyr Leu Pro Leu
Ala Tyr 675 680 685 Ala Glu Gly Thr Thr Asn Val Lys Ala Arg Glu Lys
Met Ala His Ala 690 695 700 Ser Thr Met Ala Gly Met Ala Phe Ala Asn
Ala Phe Leu Gly Val Cys 705 710 715 720 His Ser Met Ala His Lys Leu
Gly Ala Ala His His Ile Pro His Gly 725 730 735 Ile Ala Asn Ala Leu
Met Ile Asp Glu Val Ile Lys Phe Asn Ala Val 740 745 750 Asn Asp Pro
Arg Lys Gln Ala Ile Phe Pro Gln Tyr Lys Tyr Pro Asn 755 760 765 Ala
Lys Trp Arg Tyr Ala Arg Ile Ala Asp Tyr Leu Glu Leu Gly Gly 770 775
780 Asn Ser Glu Asp Glu Lys Val Gly Leu Leu Ile Lys Ala Ile Asp Glu
785 790 795 800 Leu Lys Glu Lys Ile Asn Ile Pro Lys Thr Ile Arg Glu
Ala Gly Val 805 810 815 Ala Glu Lys Lys Phe Tyr Ala Thr Leu Asp Asp
Met Ser Glu Gln Ala 820 825 830 Phe Asp Asp Gln Cys Thr Gly Ala Asn
Pro Arg Tyr Pro Leu Ile Ser 835 840 845 Glu Ile Lys Gln Met Tyr Ile
Asn Ala Phe Asp Lys Val Ser Pro Val 850 855 860 Val Asp Glu Glu Glu
Lys Leu Lys Val Ser Leu Leu 865 870 875 77491PRTClostridium
kluyveri 77Met Glu Ile Met Asp Lys Asp Leu Gln Ser Ile Gln Glu Val
Arg Thr 1 5 10 15 Leu Ile Ala Lys Ala Lys Lys Ala Gln Ala Glu Phe
Lys Asn Phe Ser 20 25 30 Gln Glu Ala Val Asn Lys Val Ile Glu Lys
Ile Ala Lys Ala Thr Glu 35 40 45 Val Glu Ala Val Lys Leu Ala Lys
Leu Ala Tyr Glu Asp Thr Gly Tyr 50 55 60 Gly Lys Trp Glu Asp Lys
Val Ile Lys Asn Lys Phe Ser Ser Ile Val 65 70 75 80 Val Tyr Asn Tyr
Ile Lys Asp Leu Lys Thr Val Gly Ile Leu Lys Glu 85 90 95 Asp Lys
Glu Lys Lys Leu Ile Asp Ile Ala Val Pro Leu Gly Val Ile 100 105 110
Ala Gly Leu Ile Pro Ser Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys 115
120 125 Val Leu Ile Ala Leu Lys Ala Gly Asn Ala Ile Val Phe Ser Pro
His 130 135 140 Pro Thr Ala Val Arg Ser Ile Thr Glu Thr Val Lys Ile
Met Gln Lys 145 150 155 160 Ala Ala Val Glu Ala Gly Ala Pro Asp Gly
Leu Ile Gln Cys Met Ser 165 170 175 Ile Leu Thr Val Glu Gly Thr Ala
Glu Leu Met Lys Asn Lys Asp Thr 180 185 190 Ala Leu Ile Leu Ala Thr
Gly Gly Glu Gly Met Val Arg Ala Ala Tyr 195 200 205 Ser Ser Gly Thr
Pro Ala Ile Gly Val Gly Pro Gly Asn Gly Pro Cys 210 215 220 Phe Ile
Glu Arg Thr Ala
Asp Ile Pro Thr Ala Val Arg Lys Val Ile 225 230 235 240 Gly Ser Asp
Thr Phe Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser 245 250 255 Ile
Ile Ala Glu Thr Val Lys Lys Ala Glu Ile Ile Glu Glu Phe Lys 260 265
270 Arg Gln Lys Gly Tyr Phe Leu Asn Ala Glu Glu Ser Glu Lys Val Gly
275 280 285 Lys Ile Leu Leu Arg Ala Asn Gly Thr Pro Asn Pro Ala Ile
Val Gly 290 295 300 Lys Asp Val Gln Ala Leu Ala Lys Leu Ala Gly Ile
Ser Ile Pro Ser 305 310 315 320 Asp Ala Val Ile Leu Leu Ser Glu Gln
Thr Asp Val Ser Pro Lys Asn 325 330 335 Pro Tyr Ala Lys Glu Lys Leu
Ala Pro Val Leu Ala Phe Tyr Thr Val 340 345 350 Glu Asp Trp His Glu
Ala Cys Glu Lys Ser Leu Ala Leu Leu His Asn 355 360 365 Gln Gly Ser
Gly His Thr Leu Ile Ile His Ser Gln Asn Glu Glu Ile 370 375 380 Ile
Arg Glu Phe Ala Leu Lys Lys Pro Val Ser Arg Ile Leu Val Asn 385 390
395 400 Ser Pro Gly Ser Leu Gly Gly Ile Gly Gly Ala Thr Asn Leu Val
Pro 405 410 415 Ser Leu Thr Leu Gly Cys Gly Ala Val Gly Gly Ser Ala
Thr Ser Asp 420 425 430 Asn Val Gly Pro Glu Asn Leu Phe Asn Ile Arg
Lys Val Ala Tyr Gly 435 440 445 Thr Thr Thr Val Glu Glu Ile Arg Glu
Ala Phe Gly Val Gly Ala Ala 450 455 460 Ser Ser Ser Ala Pro Ala Glu
Pro Glu Asp Asn Glu Asp Val Gln Ala 465 470 475 480 Ile Val Lys Ala
Ile Met Ala Lys Leu Asn Leu 485 490 78491PRTClostridium kluyveri
78Met Glu Ile Met Asp Lys Asp Leu Gln Ser Ile Gln Glu Val Arg Thr 1
5 10 15 Leu Ile Ala Lys Ala Lys Lys Ala Gln Ala Glu Phe Lys Asn Phe
Ser 20 25 30 Gln Glu Ala Val Asn Lys Val Ile Glu Lys Ile Ala Lys
Ala Thr Glu 35 40 45 Val Glu Ala Val Lys Leu Ala Lys Leu Ala Tyr
Glu Asp Thr Gly Tyr 50 55 60 Gly Lys Trp Glu Asp Lys Val Ile Lys
Asn Lys Phe Ser Ser Ile Val 65 70 75 80 Val Tyr Asn Tyr Ile Lys Asp
Leu Lys Thr Val Gly Ile Leu Lys Glu 85 90 95 Asp Lys Glu Lys Lys
Leu Ile Asp Ile Ala Val Pro Leu Gly Val Ile 100 105 110 Ala Gly Leu
Ile Pro Ser Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys 115 120 125 Val
Leu Ile Ala Leu Lys Ala Gly Asn Ala Ile Val Phe Ser Pro His 130 135
140 Pro Thr Ala Val Arg Ser Ile Thr Glu Thr Val Lys Ile Met Gln Lys
145 150 155 160 Ala Ala Val Glu Ala Gly Ala Pro Asp Gly Leu Ile Gln
Cys Met Ser 165 170 175 Ile Leu Thr Val Glu Gly Thr Ala Glu Leu Met
Lys Asn Lys Asp Thr 180 185 190 Ala Leu Ile Leu Ala Thr Gly Gly Glu
Gly Met Val Arg Ala Ala Tyr 195 200 205 Ser Ser Gly Thr Pro Ala Ile
Gly Val Gly Pro Gly Asn Gly Pro Cys 210 215 220 Phe Ile Glu Arg Thr
Ala Asp Ile Pro Thr Ala Val Arg Lys Val Ile 225 230 235 240 Gly Ser
Asp Thr Phe Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser 245 250 255
Ile Ile Ala Glu Thr Val Lys Lys Ala Glu Ile Ile Glu Glu Phe Lys 260
265 270 Arg Gln Lys Gly Tyr Phe Leu Asn Ala Glu Glu Ser Glu Lys Val
Gly 275 280 285 Lys Ile Leu Leu Arg Ala Asn Gly Thr Pro Asn Pro Ala
Ile Val Gly 290 295 300 Lys Asp Val Gln Ala Leu Ala Lys Leu Ala Gly
Ile Ser Ile Pro Ser 305 310 315 320 Asp Ala Val Ile Leu Leu Ser Glu
Gln Thr Asp Val Ser Pro Lys Asn 325 330 335 Pro Tyr Ala Lys Glu Lys
Leu Ala Pro Val Leu Ala Phe Tyr Thr Val 340 345 350 Glu Asp Trp His
Glu Ala Cys Glu Lys Ser Leu Ala Leu Leu His Asn 355 360 365 Gln Gly
Ser Gly His Thr Leu Ile Ile His Ser Gln Asn Glu Glu Ile 370 375 380
Ile Arg Glu Phe Ala Leu Lys Lys Pro Val Ser Arg Ile Leu Val Asn 385
390 395 400 Ser Pro Gly Ser Leu Gly Gly Ile Gly Gly Ala Thr Asn Leu
Val Pro 405 410 415 Ser Leu Thr Leu Gly Cys Gly Ala Val Gly Gly Ser
Ala Thr Ser Asp 420 425 430 Asn Val Gly Pro Glu Asn Leu Phe Asn Ile
Arg Lys Val Ala Tyr Gly 435 440 445 Thr Thr Thr Val Glu Glu Ile Arg
Glu Ala Phe Gly Val Gly Ala Ala 450 455 460 Ser Ser Ser Ala Pro Ala
Glu Pro Glu Asp Asn Glu Asp Val Gln Ala 465 470 475 480 Ile Val Lys
Ala Ile Met Ala Lys Leu Asn Leu 485 490 79469PRTPropionibacterium
freudenreichi 79Met Thr Ile Ser Pro Glu Leu Ile Gln Gln Val Val Arg
Glu Thr Val 1 5 10 15 Arg Glu Val Ile Ser Arg Gln Asp Ser Gly Thr
Asp Ala Pro Ser Gly 20 25 30 Thr Asp Gly Ile Phe Thr Asp Met Asn
Ser Ala Val Asp Ala Ala Asp 35 40 45 Val Ala Trp Arg Gln Tyr Met
Asp Cys Ser Leu Arg Asp Arg Asn Arg 50 55 60 Phe Ile Gln Ala Ile
Arg Asp Val Ala Ser Glu Pro Asp Asn Leu Glu 65 70 75 80 Tyr Met Ala
Thr Ala Thr Val Glu Glu Thr Gly Met Gly Asn Val Pro 85 90 95 His
Lys Ile Leu Lys Asn Arg Tyr Ala Ala Leu Tyr Thr Pro Gly Thr 100 105
110 Glu Asp Ile Ile Thr Glu Ala Trp Ser Gly Asp Asp Gly Leu Thr Thr
115 120 125 Val Glu Phe Ser Pro Phe Gly Val Ile Gly Ala Ile Thr Pro
Thr Thr 130 135 140 Asn Pro Thr Glu Thr Val Ile Asn Asn Thr Ile Gly
Met Leu Ala Ala 145 150 155 160 Gly Asn Ala Val Val Phe Ser Pro His
Pro Arg Ala Lys Lys Ile Thr 165 170 175 Leu Trp Leu Val Arg Lys Ile
Asn Arg Ala Leu Ala Ala Ala Gly Ala 180 185 190 Pro Ala Asn Leu Val
Val Thr Val Glu Glu Pro Ser Ile Asp Asn Thr 195 200 205 Asn Ala Met
Met Ser His Glu Lys Val Arg Met Leu Val Ala Thr Gly 210 215 220 Gly
Pro Gly Ile Val Lys Ala Val Leu Ser Ser Gly Lys Lys Ala Ile 225 230
235 240 Gly Ala Gly Ala Gly Asn Pro Pro Ala Val Val Asp Asp Thr Ala
Asp 245 250 255 Ile Ala Lys Ala Ala Arg Asp Ile Val Asp Gly Ala Ser
Phe Asp Asn 260 265 270 Asn Leu Pro Cys Thr Ala Glu Lys Glu Val Leu
Ala Val Asp Ser Ile 275 280 285 Ala Asp Leu Leu Lys Phe Glu Met Leu
Lys His Gly Cys Phe Glu Leu 290 295 300 Lys Asp Arg Ala Val Met Asp
Lys Leu Ala Ala Leu Val Thr Lys Gly 305 310 315 320 Gln His Ala Asn
Ala Ala Tyr Val Gly Lys Pro Ala Ala Gln Leu Ala 325 330 335 Ser Glu
Val Gly Leu Ser Ala Pro Lys Asp Thr Arg Leu Leu Ile Cys 340 345 350
Glu Val Pro Phe Asp His Pro Phe Val Gln Val Glu Leu Met Met Pro 355
360 365 Ile Leu Pro Ile Val Arg Met Pro Asp Val Asp Thr Ala Ile Asp
Lys 370 375 380 Ala Val Glu Val Glu His Gly Asn Arg His Thr Ala Val
Met His Ser 385 390 395 400 Ser Asn Val Asn Ala Leu Thr Lys Met Gly
Lys Leu Ile Gln Thr Thr 405 410 415 Ile Phe Val Lys Asn Gly Pro Ser
Tyr Asn Gly Ile Gly Ile Asp Gly 420 425 430 Glu Gly Phe Pro Thr Phe
Thr Ile Ala Gly Pro Thr Gly Glu Gly Leu 435 440 445 Thr Ser Ala Arg
Cys Phe Ala Arg Lys Arg Arg Cys Val Leu Lys Ser 450 455 460 Gly Leu
Asn Ile Arg 465 80858PRTClostridium acetobutylicum 80Met Lys Val
Thr Asn Gln Lys Glu Leu Lys Gln Lys Leu Asn Glu Leu 1 5 10 15 Arg
Glu Ala Gln Lys Lys Phe Ala Thr Tyr Thr Gln Glu Gln Val Asp 20 25
30 Lys Ile Phe Lys Gln Cys Ala Ile Ala Ala Ala Lys Glu Arg Ile Asn
35 40 45 Leu Ala Lys Leu Ala Val Glu Glu Thr Gly Ile Gly Leu Val
Glu Asp 50 55 60 Lys Ile Ile Lys Asn His Phe Ala Ala Glu Tyr Ile
Tyr Asn Lys Tyr 65 70 75 80 Lys Asn Glu Lys Thr Cys Gly Ile Ile Asp
His Asp Asp Ser Leu Gly 85 90 95 Ile Thr Lys Val Ala Glu Pro Ile
Gly Ile Val Ala Ala Ile Val Pro 100 105 110 Thr Thr Asn Pro Thr Ser
Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 115 120 125 Lys Thr Arg Asn
Ala Ile Phe Phe Ser Pro His Pro Arg Ala Lys Lys 130 135 140 Ser Thr
Ile Ala Ala Ala Lys Leu Ile Leu Asp Ala Ala Val Lys Ala 145 150 155
160 Gly Ala Pro Lys Asn Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile Glu
165 170 175 Leu Ser Gln Asp Leu Met Ser Glu Ala Asp Ile Ile Leu Ala
Thr Gly 180 185 190 Gly Pro Ser Met Val Lys Ala Ala Tyr Ser Ser Gly
Lys Pro Ala Ile 195 200 205 Gly Val Gly Ala Gly Asn Thr Pro Ala Ile
Ile Asp Glu Ser Ala Asp 210 215 220 Ile Asp Met Ala Val Ser Ser Ile
Ile Leu Ser Lys Thr Tyr Asp Asn 225 230 235 240 Gly Val Ile Cys Ala
Ser Glu Gln Ser Ile Leu Val Met Asn Ser Ile 245 250 255 Tyr Glu Lys
Val Lys Glu Glu Phe Val Lys Arg Gly Ser Tyr Ile Leu 260 265 270 Asn
Gln Asn Glu Ile Ala Lys Ile Lys Glu Thr Met Phe Lys Asn Gly 275 280
285 Ala Ile Asn Ala Asp Ile Val Gly Lys Ser Ala Tyr Ile Ile Ala Lys
290 295 300 Met Ala Gly Ile Glu Val Pro Gln Thr Thr Lys Ile Leu Ile
Gly Glu 305 310 315 320 Val Gln Ser Val Glu Lys Ser Glu Leu Phe Ser
His Glu Lys Leu Ser 325 330 335 Pro Val Leu Ala Met Tyr Lys Val Lys
Asp Phe Asp Glu Ala Leu Lys 340 345 350 Lys Ala Gln Arg Leu Ile Glu
Leu Gly Gly Ser Gly His Thr Ser Ser 355 360 365 Leu Tyr Ile Asp Ser
Gln Asn Asn Lys Asp Lys Val Lys Glu Phe Gly 370 375 380 Leu Ala Met
Lys Thr Ser Arg Thr Phe Ile Asn Met Pro Ser Ser Gln 385 390 395 400
Gly Ala Ser Gly Asp Leu Tyr Asn Phe Ala Ile Ala Pro Ser Phe Thr 405
410 415 Leu Gly Cys Gly Thr Trp Gly Gly Asn Ser Val Ser Gln Asn Val
Glu 420 425 430 Pro Lys His Leu Leu Asn Ile Lys Ser Val Ala Glu Arg
Arg Glu Asn 435 440 445 Met Leu Trp Phe Lys Val Pro Gln Lys Ile Tyr
Phe Lys Tyr Gly Cys 450 455 460 Leu Arg Phe Ala Leu Lys Glu Leu Lys
Asp Met Asn Lys Lys Arg Ala 465 470 475 480 Phe Ile Val Thr Asp Lys
Asp Leu Phe Lys Leu Gly Tyr Val Asn Lys 485 490 495 Ile Thr Lys Val
Leu Asp Glu Ile Asp Ile Lys Tyr Ser Ile Phe Thr 500 505 510 Asp Ile
Lys Ser Asp Pro Thr Ile Asp Ser Val Lys Lys Gly Ala Lys 515 520 525
Glu Met Leu Asn Phe Glu Pro Asp Thr Ile Ile Ser Ile Gly Gly Gly 530
535 540 Ser Pro Met Asp Ala Ala Lys Val Met His Leu Leu Tyr Glu Tyr
Pro 545 550 555 560 Glu Ala Glu Ile Glu Asn Leu Ala Ile Asn Phe Met
Asp Ile Arg Lys 565 570 575 Arg Ile Cys Asn Phe Pro Lys Leu Gly Thr
Lys Ala Ile Ser Val Ala 580 585 590 Ile Pro Thr Thr Ala Gly Thr Gly
Ser Glu Ala Thr Pro Phe Ala Val 595 600 605 Ile Thr Asn Asp Glu Thr
Gly Met Lys Tyr Pro Leu Thr Ser Tyr Glu 610 615 620 Leu Thr Pro Asn
Met Ala Ile Ile Asp Thr Glu Leu Met Leu Asn Met 625 630 635 640 Pro
Arg Lys Leu Thr Ala Ala Thr Gly Ile Asp Ala Leu Val His Ala 645 650
655 Ile Glu Ala Tyr Val Ser Val Met Ala Thr Asp Tyr Thr Asp Glu Leu
660 665 670 Ala Leu Arg Ala Ile Lys Met Ile Phe Lys Tyr Leu Pro Arg
Ala Tyr 675 680 685 Lys Asn Gly Thr Asn Asp Ile Glu Ala Arg Glu Lys
Met Ala His Ala 690 695 700 Ser Asn Ile Ala Gly Met Ala Phe Ala Asn
Ala Phe Leu Gly Val Cys 705 710 715 720 His Ser Met Ala His Lys Leu
Gly Ala Met His His Val Pro His Gly 725 730 735 Ile Ala Cys Ala Val
Leu Ile Glu Glu Val Ile Lys Tyr Asn Ala Thr 740 745 750 Asp Cys Pro
Thr Lys Gln Thr Ala Phe Pro Gln Tyr Lys Ser Pro Asn 755 760 765 Ala
Lys Arg Lys Tyr Ala Glu Ile Ala Glu Tyr Leu Asn Leu Lys Gly 770 775
780 Thr Ser Asp Thr Glu Lys Val Thr Ala Leu Ile Glu Ala Ile Ser Lys
785 790 795 800 Leu Lys Ile Asp Leu Ser Ile Pro Gln Asn Ile Ser Ala
Ala Gly Ile 805 810 815 Asn Lys Lys Asp Phe Tyr Asn Thr Leu Asp Lys
Met Ser Glu Leu Ala 820 825 830 Phe Asp Asp Gln Cys Thr Thr Ala Asn
Pro Arg Tyr Pro Leu Ile Ser 835 840 845 Glu Leu Lys Asp Ile Tyr Ile
Lys Ser Phe 850 855 81862PRTClostridium acetobutylicum 81Met Lys
Val Thr Thr Val Lys Glu Leu Asp Glu Lys Leu Lys Val Ile 1 5 10 15
Lys Glu Ala Gln Lys Lys Phe Ser Cys Tyr Ser Gln Glu Met Val Asp 20
25 30 Glu Ile Phe Arg Asn Ala Ala Met Ala Ala Ile Asp Ala Arg Ile
Glu 35 40 45 Leu Ala Lys Ala Ala Val Leu Glu Thr Gly Met Gly Leu
Val Glu Asp 50 55 60 Lys Val Ile Lys Asn His Phe Ala Gly Glu Tyr
Ile Tyr Asn Lys Tyr 65 70 75 80 Lys Asp Glu Lys Thr Cys Gly Ile Ile
Glu Arg Asn Glu Pro Tyr Gly 85 90 95 Ile Thr Lys Ile Ala Glu Pro
Ile Gly Val Val Ala Ala Ile Ile Pro 100 105 110 Val Thr Asn Pro Thr
Ser Thr Thr Ile Phe Lys Ser Leu Ile Ser Leu 115 120 125 Lys Thr Arg
Asn Gly Ile Phe Phe Ser Pro His Pro Arg Ala Lys Lys 130 135 140 Ser
Thr Ile Leu Ala Ala Lys Thr Ile Leu Asp Ala Ala Val Lys Ser 145 150
155 160 Gly Ala Pro Glu Asn Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile
Glu 165 170 175 Leu Thr Gln Tyr Leu Met Gln Lys Ala Asp Ile Thr Leu
Ala Thr Gly 180 185 190 Gly Pro Ser Leu Val Lys Ser Ala Tyr Ser Ser
Gly Lys Pro Ala Ile 195 200
205 Gly Val Gly Pro Gly Asn Thr Pro Val Ile Ile Asp Glu Ser Ala His
210 215 220 Ile Lys Met Ala Val Ser Ser Ile Ile Leu Ser Lys Thr Tyr
Asp Asn 225 230 235 240 Gly Val Ile Cys Ala Ser Glu Gln Ser Val Ile
Val Leu Lys Ser Ile 245 250 255 Tyr Asn Lys Val Lys Asp Glu Phe Gln
Glu Arg Gly Ala Tyr Ile Ile 260 265 270 Lys Lys Asn Glu Leu Asp Lys
Val Arg Glu Val Ile Phe Lys Asp Gly 275 280 285 Ser Val Asn Pro Lys
Ile Val Gly Gln Ser Ala Tyr Thr Ile Ala Ala 290 295 300 Met Ala Gly
Ile Lys Val Pro Lys Thr Thr Arg Ile Leu Ile Gly Glu 305 310 315 320
Val Thr Ser Leu Gly Glu Glu Glu Pro Phe Ala His Glu Lys Leu Ser 325
330 335 Pro Val Leu Ala Met Tyr Glu Ala Asp Asn Phe Asp Asp Ala Leu
Lys 340 345 350 Lys Ala Val Thr Leu Ile Asn Leu Gly Gly Leu Gly His
Thr Ser Gly 355 360 365 Ile Tyr Ala Asp Glu Ile Lys Ala Arg Asp Lys
Ile Asp Arg Phe Ser 370 375 380 Ser Ala Met Lys Thr Val Arg Thr Phe
Val Asn Ile Pro Thr Ser Gln 385 390 395 400 Gly Ala Ser Gly Asp Leu
Tyr Asn Phe Arg Ile Pro Pro Ser Phe Thr 405 410 415 Leu Gly Cys Gly
Phe Trp Gly Gly Asn Ser Val Ser Glu Asn Val Gly 420 425 430 Pro Lys
His Leu Leu Asn Ile Lys Thr Val Ala Glu Arg Arg Glu Asn 435 440 445
Met Leu Trp Phe Arg Val Pro His Lys Val Tyr Phe Lys Phe Gly Cys 450
455 460 Leu Gln Phe Ala Leu Lys Asp Leu Lys Asp Leu Lys Lys Lys Arg
Ala 465 470 475 480 Phe Ile Val Thr Asp Ser Asp Pro Tyr Asn Leu Asn
Tyr Val Asp Ser 485 490 495 Ile Ile Lys Ile Leu Glu His Leu Asp Ile
Asp Phe Lys Val Phe Asn 500 505 510 Lys Val Gly Arg Glu Ala Asp Leu
Lys Thr Ile Lys Lys Ala Thr Glu 515 520 525 Glu Met Ser Ser Phe Met
Pro Asp Thr Ile Ile Ala Leu Gly Gly Thr 530 535 540 Pro Glu Met Ser
Ser Ala Lys Leu Met Trp Val Leu Tyr Glu His Pro 545 550 555 560 Glu
Val Lys Phe Glu Asp Leu Ala Ile Lys Phe Met Asp Ile Arg Lys 565 570
575 Arg Ile Tyr Thr Phe Pro Lys Leu Gly Lys Lys Ala Met Leu Val Ala
580 585 590 Ile Thr Thr Ser Ala Gly Ser Gly Ser Glu Val Thr Pro Phe
Ala Leu 595 600 605 Val Thr Asp Asn Asn Thr Gly Asn Lys Tyr Met Leu
Ala Asp Tyr Glu 610 615 620 Met Thr Pro Asn Met Ala Ile Val Asp Ala
Glu Leu Met Met Lys Met 625 630 635 640 Pro Lys Gly Leu Thr Ala Tyr
Ser Gly Ile Asp Ala Leu Val Asn Ser 645 650 655 Ile Glu Ala Tyr Thr
Ser Val Tyr Ala Ser Glu Tyr Thr Asn Gly Leu 660 665 670 Ala Leu Glu
Ala Ile Arg Leu Ile Phe Lys Tyr Leu Pro Glu Ala Tyr 675 680 685 Lys
Asn Gly Arg Thr Asn Glu Lys Ala Arg Glu Lys Met Ala His Ala 690 695
700 Ser Thr Met Ala Gly Met Ala Ser Ala Asn Ala Phe Leu Gly Leu Cys
705 710 715 720 His Ser Met Ala Ile Lys Leu Ser Ser Glu His Asn Ile
Pro Ser Gly 725 730 735 Ile Ala Asn Ala Leu Leu Ile Glu Glu Val Ile
Lys Phe Asn Ala Val 740 745 750 Asp Asn Pro Val Lys Gln Ala Pro Cys
Pro Gln Tyr Lys Tyr Pro Asn 755 760 765 Thr Ile Phe Arg Tyr Ala Arg
Ile Ala Asp Tyr Ile Lys Leu Gly Gly 770 775 780 Asn Thr Asp Glu Glu
Lys Val Asp Leu Leu Ile Asn Lys Ile His Glu 785 790 795 800 Leu Lys
Lys Ala Leu Asn Ile Pro Thr Ser Ile Lys Asp Ala Gly Val 805 810 815
Leu Glu Glu Asn Phe Tyr Ser Ser Leu Asp Arg Ile Ser Glu Leu Ala 820
825 830 Leu Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Phe Pro Leu Thr
Ser 835 840 845 Glu Ile Lys Glu Met Tyr Ile Asn Cys Phe Lys Lys Gln
Pro 850 855 860 82453PRTVibrio fluvialis 82Met Asn Lys Pro Gln Ser
Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 1 5 10 15 Tyr Gly Phe Thr
Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 20 25 30 Val Thr
His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg 35 40 45
Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 50
55 60 His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe
Pro 65 70 75 80 Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr
Val Met Leu 85 90 95 Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp
Ser Gly Arg Val Phe 100 105 110 Tyr Thr Asn Ser Gly Ser Glu Ala Asn
Asp Thr Met Val Lys Met Leu 115 120 125 Trp Phe Leu His Ala Ala Glu
Gly Lys Pro Gln Lys Arg Lys Ile Leu 130 135 140 Thr Arg Trp Asn Ala
Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 145 150 155 160 Thr Gly
Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 165 170 175
Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 180
185 190 Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu
Thr 195 200 205 Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe
Ala Glu Pro 210 215 220 Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala
Lys Gly Tyr Phe Gln 225 230 235 240 Ala Ile Leu Pro Ile Leu Arg Lys
Tyr Asp Ile Pro Val Ile Ser Asp 245 250 255 Glu Val Ile Cys Gly Phe
Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 260 265 270 Thr Tyr Asp Phe
Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 275 280 285 Ala Gly
Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 290 295 300
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 305
310 315 320 Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu
Lys Ala 325 330 335 Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn
Val Arg Arg Leu 340 345 350 Ala Pro Arg Phe Glu Glu Arg Leu Lys His
Ile Ala Glu Arg Pro Asn 355 360 365 Ile Gly Glu Tyr Arg Gly Ile Gly
Phe Met Trp Ala Leu Glu Ala Val 370 375 380 Lys Asp Lys Ala Ser Lys
Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 385 390 395 400 Glu Arg Ile
Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 405 410 415 Leu
Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 420 425
430 Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val
435 440 445 Phe Ala Glu Val Ala 450 83449PRTBacillus
weihenstephanensis 83Met Gln Ala Thr Glu Gln Thr Gln Ser Leu Lys
Lys Thr Asp Glu Lys 1 5 10 15 Tyr Leu Trp His Ala Met Arg Gly Ala
Ala Pro Ser Pro Thr Asn Leu 20 25 30 Ile Ile Thr Lys Ala Glu Gly
Ala Trp Val Thr Asp Ile Asp Gly Asn 35 40 45 Arg Tyr Leu Asp Gly
Met Ser Gly Leu Trp Cys Val Asn Val Gly Tyr 50 55 60 Gly Arg Lys
Glu Leu Ala Arg Ala Ala Phe Glu Gln Leu Glu Glu Met 65 70 75 80 Pro
Tyr Phe Pro Leu Thr Gln Ser His Val Pro Ala Ile Lys Leu Ala 85 90
95 Glu Lys Leu Asn Glu Trp Leu Asp Asp Glu Tyr Val Ile Phe Phe Ser
100 105 110 Asn Ser Gly Ser Glu Ala Asn Glu Thr Ala Phe Lys Ile Ala
Arg Gln 115 120 125 Tyr His Gln Gln Lys Gly Asp His Gly Arg Tyr Lys
Phe Ile Ser Arg 130 135 140 Tyr Arg Ala Tyr His Gly Asn Ser Met Gly
Ala Leu Ala Ala Thr Gly 145 150 155 160 Gln Ala Gln Arg Lys Tyr Lys
Tyr Glu Pro Leu Gly Gln Gly Phe Leu 165 170 175 His Val Ala Pro Pro
Asp Thr Tyr Arg Asn Pro Glu Asp Val His Thr 180 185 190 Leu Ala Ser
Ala Glu Glu Ile Asp Arg Val Met Thr Trp Glu Leu Ser 195 200 205 Gln
Thr Val Ala Gly Val Ile Met Glu Pro Ile Ile Thr Gly Gly Gly 210 215
220 Ile Leu Met Pro Pro Asp Gly Tyr Met Gly Lys Val Lys Glu Ile Cys
225 230 235 240 Glu Lys His Gly Ala Leu Leu Ile Cys Asp Glu Val Ile
Cys Gly Phe 245 250 255 Gly Arg Thr Gly Lys Pro Phe Gly Phe Met Asn
Tyr Gly Val Lys Pro 260 265 270 Asp Ile Ile Thr Met Ala Lys Gly Ile
Thr Ser Ala Tyr Leu Pro Leu 275 280 285 Ser Ala Thr Ala Val Arg Arg
Glu Val Tyr Glu Ala Phe Val Gly Ser 290 295 300 Asp Asp Tyr Asp Arg
Phe Arg His Val Asn Thr Phe Gly Gly Asn Pro 305 310 315 320 Ala Ala
Cys Ala Leu Ala Leu Lys Asn Leu Glu Ile Met Glu Asn Glu 325 330 335
Lys Leu Ile Glu Arg Ser Lys Glu Leu Gly Glu Arg Leu Leu Tyr Glu 340
345 350 Leu Glu Asp Val Lys Glu His Pro Asn Val Gly Asp Val Arg Gly
Lys 355 360 365 Gly Leu Leu Leu Gly Ile Glu Leu Val Glu Asp Lys Gln
Thr Lys Glu 370 375 380 Pro Ala Ser Ile Glu Lys Met Asn Lys Val Ile
Asn Ala Cys Lys Glu 385 390 395 400 Lys Gly Leu Ile Ile Gly Lys Asn
Gly Asp Thr Val Ala Gly Tyr Asn 405 410 415 Asn Ile Leu Gln Leu Ala
Pro Pro Leu Ser Ile Thr Glu Glu Asp Phe 420 425 430 Thr Phe Ile Val
Lys Thr Met Lys Glu Cys Leu Ser Arg Ile Asn Gly 435 440 445 Gln
84456PRTPseudomonas aeruginosa 84Met Asn Ser Gln Ile Thr Asn Ala
Lys Thr Arg Glu Trp Gln Ala Leu 1 5 10 15 Ser Arg Asp His His Leu
Pro Pro Phe Thr Asp Tyr Lys Gln Leu Asn 20 25 30 Glu Lys Gly Ala
Arg Ile Ile Thr Lys Ala Glu Gly Val Tyr Ile Trp 35 40 45 Asp Ser
Glu Gly Asn Lys Ile Leu Asp Ala Met Ala Gly Leu Trp Cys 50 55 60
Val Asn Val Gly Tyr Gly Arg Glu Glu Leu Val Gln Ala Ala Thr Arg 65
70 75 80 Gln Met Arg Glu Leu Pro Phe Tyr Asn Leu Phe Phe Gln Thr
Ala His 85 90 95 Pro Pro Val Val Glu Leu Ala Lys Ala Ile Ala Asp
Val Ala Pro Glu 100 105 110 Gly Met Asn His Val Phe Phe Thr Gly Ser
Gly Ser Glu Ala Asn Asp 115 120 125 Thr Val Leu Arg Met Val Arg His
Tyr Trp Ala Thr Lys Gly Gln Pro 130 135 140 Gln Lys Lys Val Val Ile
Gly Arg Trp Asn Gly Tyr His Gly Ser Thr 145 150 155 160 Val Ala Gly
Val Ser Leu Gly Gly Met Lys Ala Leu His Glu Gln Gly 165 170 175 Asp
Phe Pro Ile Pro Gly Ile Val His Ile Ala Gln Pro Tyr Trp Tyr 180 185
190 Gly Glu Gly Gly Asp Met Ser Pro Asp Glu Phe Gly Val Trp Ala Ala
195 200 205 Glu Gln Leu Glu Lys Lys Ile Leu Glu Val Gly Glu Glu Asn
Val Ala 210 215 220 Ala Phe Ile Ala Glu Pro Ile Gln Gly Ala Gly Gly
Val Ile Val Pro 225 230 235 240 Pro Asp Thr Tyr Trp Pro Lys Ile Arg
Glu Ile Leu Ala Lys Tyr Asp 245 250 255 Ile Leu Phe Ile Ala Asp Glu
Val Ile Cys Gly Phe Gly Arg Thr Gly 260 265 270 Glu Trp Phe Gly Ser
Gln Tyr Tyr Gly Asn Ala Pro Asp Leu Met Pro 275 280 285 Ile Ala Lys
Gly Leu Thr Ser Gly Tyr Ile Pro Met Gly Gly Val Val 290 295 300 Val
Arg Asp Glu Ile Val Glu Val Leu Asn Gln Gly Gly Glu Phe Tyr 305 310
315 320 His Gly Phe Thr Tyr Ser Gly His Pro Val Ala Ala Ala Val Ala
Leu 325 330 335 Glu Asn Ile Arg Ile Leu Arg Glu Glu Lys Ile Ile Glu
Lys Val Lys 340 345 350 Ala Glu Thr Ala Pro Tyr Leu Gln Lys Arg Trp
Gln Glu Leu Ala Asp 355 360 365 His Pro Leu Val Gly Glu Ala Arg Gly
Val Gly Met Val Ala Ala Leu 370 375 380 Glu Leu Val Lys Asn Lys Lys
Thr Arg Glu Arg Phe Thr Asp Lys Gly 385 390 395 400 Val Gly Met Leu
Cys Arg Glu His Cys Phe Arg Asn Gly Leu Ile Met 405 410 415 Arg Ala
Val Gly Asp Thr Met Ile Ile Ser Pro Pro Leu Val Ile Asp 420 425 430
Pro Ser Gln Ile Asp Glu Leu Ile Thr Leu Ala Arg Lys Cys Leu Asp 435
440 445 Gln Thr Ala Ala Ala Val Leu Ala 450 455 85538PRTPenicillium
Chrysogenum 85Met Thr Ala Leu Arg Ile Ser Thr Thr Leu Ser Arg Lys
Ala Leu Thr 1 5 10 15 Ala Cys Arg Pro Arg Leu Phe Leu Gly Val Arg
Thr Ser Val Arg Pro 20 25 30 Trp Gln Pro Phe Ser Thr Ser Thr Ser
Thr Arg Tyr Ser Ile Thr Thr 35 40 45 Pro Leu Lys Ser Leu Ala Pro
Lys Val Glu Arg Ser Gly Ser Lys Leu 50 55 60 Tyr Lys Asp Ala Asp
Ala Ala Val Ala Asp Ile Lys Ser Gly Ser Thr 65 70 75 80 Ile Leu Ser
Ser Gly Phe Gly Leu Cys Gly Val Ala Glu Thr Leu Ile 85 90 95 Asn
Ala Met His Arg Arg Gly Ala Asp Gln Leu His Ser Leu Thr Ala 100 105
110 Val Ser Asn Asn Ala Gly Ala Ala Gly Lys Gly Gly Leu Ser Thr Leu
115 120 125 Ser Gln Asn Gly Gln Ile Asn Arg Leu Ile Leu Ser Tyr Leu
Gly Asn 130 135 140 Asn Lys Ala Leu Glu Lys Lys Tyr Leu Thr Gly His
Ile Ala Ile Glu 145 150 155 160 Leu Cys Pro Gln Gly Thr Leu Ala Glu
Arg Leu Arg Ala Gly Gly Ala 165 170 175 Gly Ile Pro Ala Phe Phe Thr
Pro Thr Gly Glu Gly Lys Ile Pro Val 180 185 190 Arg Met Asp Glu Ser
Gly Lys Val Leu Glu Ser Gly Lys Pro Arg Glu 195 200 205 Thr Arg Glu
Phe Asn Gly Lys Thr Tyr Leu Met Glu Glu Ala Leu Thr 210 215 220 Gly
Asp Val Ala Ile Leu Arg Ala Trp Lys Ala Asp Glu Ala Gly Asn 225 230
235 240 Cys Val Phe Arg Tyr Thr Thr Lys Ala Phe Gly Pro Ile Met Ala
Lys 245 250 255 Ala Ala Thr Leu Thr Ile Val Glu Ala Glu Asn Ile Val
Pro Ile Gly 260 265 270 Ser Ile Asp Pro Asn Asp Val Asp
Leu Pro Gly Ile Phe Val Asp Arg 275 280 285 Ile Val Pro Ala Thr Asp
Asp Lys His Ile Glu Ile Arg Lys Leu Arg 290 295 300 Ser Gly Glu Thr
Thr Val Ala Gly Ser Gly Lys Asp Glu Ala Arg Ile 305 310 315 320 Gln
Arg Glu Leu Ile Gly Arg Arg Ala Ala Lys Glu Leu Lys Pro Gly 325 330
335 Phe Tyr Val Asn Leu Gly Val Gly Ile Pro Thr Leu Ala Pro Ser Phe
340 345 350 Leu Pro Lys Asp Val Lys Val Trp Ile Gln Ser Glu Asn Gly
Ile Leu 355 360 365 Gly Met Gly Asp Tyr Pro Thr Glu Gln Glu Leu Asp
Pro Asp Ile Ile 370 375 380 Asn Ala Gly Lys Glu Thr Val Thr Leu Val
Pro Gly Ala Ala Thr Phe 385 390 395 400 Asp Ser Ser Glu Ser Phe Gly
Met Ile Arg Gly Gly His Val Asp Val 405 410 415 Ser Ile Leu Gly Ala
Leu Gln Val Ser Ala Asn Gly Asp Leu Ala Asn 420 425 430 Tyr Met Ile
Pro Gly Lys Val Phe Lys Gly Met Gly Gly Ala Met Asp 435 440 445 Leu
Ile Ser Asn Pro Glu Lys Thr Lys Ile Val Val Ala Thr Ser His 450 455
460 Val Ala Lys Asp Gly Ser Pro Lys Ile Val Gln Lys Cys Ser Leu Pro
465 470 475 480 Leu Thr Gly Ala Asn Val Val Ser Thr Ile Ile Thr Asp
Leu Cys Val 485 490 495 Phe Gln Val Asp Arg Ala Thr Gly Glu Leu Thr
Leu Thr Glu Leu Ala 500 505 510 Pro Gly Val Glu Val Glu Glu Val Gln
Ser Lys Thr Asp Ala Lys Phe 515 520 525 Thr Ile Ala Asp Thr Leu Glu
Ile Met Glu 530 535 861362DNAVibrio fluvialisCDS(1)..(1362) 86atg
aac aaa ccg caa agc tgg gaa gcc cgg gcc gag acc tat tcg ctc 48Met
Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 1 5 10
15 tat ggt ttc acc gac atg cct tcg ctg cat cag cgc ggc acg gtc gtc
96Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val
20 25 30 gtg acc cat ggc gag gga ccc tat atc gtc gat gtg aat ggc
cgg cgt 144Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly
Arg Arg 35 40 45 tat ctg gac gcc aac tcg ggc ctg tgg aac atg gtc
gcg ggc ttt gac 192Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val
Ala Gly Phe Asp 50 55 60 cac aag ggg ctg atc gac gcc gcc aag gcc
caa tac gag cgt ttt ccc 240His Lys Gly Leu Ile Asp Ala Ala Lys Ala
Gln Tyr Glu Arg Phe Pro 65 70 75 80 ggt tat cac gcc ttt ttc ggc cgc
atg tcc gat cag acg gta atg ctg 288Gly Tyr His Ala Phe Phe Gly Arg
Met Ser Asp Gln Thr Val Met Leu 85 90 95 tcg gaa aag ctg gtc gag
gtg tcg ccc ttt gat tcg ggc cgg gtg ttc 336Ser Glu Lys Leu Val Glu
Val Ser Pro Phe Asp Ser Gly Arg Val Phe 100 105 110 tat aca aac tcg
ggg tcc gag gcg aat gac acc atg gtc aag atg cta 384Tyr Thr Asn Ser
Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 115 120 125 tgg ttc
ctg cat gca gcc gag ggc aaa ccg caa aag cgc aag atc ctg 432Trp Phe
Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 130 135 140
acc cgc tgg aac gcc tat cac ggc gtg acc gcc gtt tcg gcc agc atg
480Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met
145 150 155 160 acc ggc aag ccc tat aat tcg gtc ttt ggc ctg ccg ctg
ccg ggc ttt 528Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu
Pro Gly Phe 165 170 175 gtg cat ctg acc tgc ccg cat tac tgg cgc tat
ggc gaa gag ggc gaa 576Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr
Gly Glu Glu Gly Glu 180 185 190 acc gaa gag cag ttc gtc gcc cgc ctc
gcc cgc gag ctg gag gaa acg 624Thr Glu Glu Gln Phe Val Ala Arg Leu
Ala Arg Glu Leu Glu Glu Thr 195 200 205 atc cag cgc gag ggc gcc gac
acc atc gcc ggt ttc ttt gcc gaa ccg 672Ile Gln Arg Glu Gly Ala Asp
Thr Ile Ala Gly Phe Phe Ala Glu Pro 210 215 220 gtg atg ggc gcg ggc
ggc gtg att ccc ccg gcc aag ggc tat ttc cag 720Val Met Gly Ala Gly
Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 225 230 235 240 gcg atc
ctg cca atc ctg cgc aaa tat gac atc ccg gtc atc tcg gac 768Ala Ile
Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 245 250 255
gag gtg atc tgc ggt ttc gga cgc acc ggt aac acc tgg ggc tgc gtg
816Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val
260 265 270 acc tat gac ttt aca ccc gat gca atc atc tcg tcc aag aat
ctt aca 864Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn
Leu Thr 275 280 285 gcg ggc ttt ttc ccc atg ggg gcg gtg atc ctt ggc
ccg gaa ctt tcc 912Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly
Pro Glu Leu Ser 290 295 300 aaa cgg ctg gaa acc gca atc gag gcg atc
gag gaa ttc ccc cat ggc 960Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile
Glu Glu Phe Pro His Gly 305 310 315 320 ttt acc gcc tcg ggc cat ccg
gtc ggc tgt gct att gcg ctg aaa gca 1008Phe Thr Ala Ser Gly His Pro
Val Gly Cys Ala Ile Ala Leu Lys Ala 325 330 335 atc gac gtg gtg atg
aat gaa ggg ctg gct gag aac gtc cgc cgc ctt 1056Ile Asp Val Val Met
Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 340 345 350 gcc ccc cgt
ttc gag gaa agg ctg aaa cat atc gcc gag cgc ccg aac 1104Ala Pro Arg
Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 355 360 365 atc
ggt gaa tat cgc ggc atc ggc ttc atg tgg gcg ctg gag gct gtc 1152Ile
Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 370 375
380 aag gac aag gca agc aag acg ccg ttc gac ggc aac ctg tcg gtc agc
1200Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser
385 390 395 400 gag cgt atc gcc aat acc tgc acc gat ctg ggg ctg att
tgc cgg ccg 1248Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile
Cys Arg Pro 405 410 415 ctt ggt cag tcc gtc gtc ctt tgt ccg ccc ttt
atc ctg acc gag gcg 1296Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe
Ile Leu Thr Glu Ala 420 425 430 cag atg gat gag atg ttc gat aaa ctc
gaa aaa gcc ctt gat aag gtc 1344Gln Met Asp Glu Met Phe Asp Lys Leu
Glu Lys Ala Leu Asp Lys Val 435 440 445 ttt gcc gag gtt gcc tga
1362Phe Ala Glu Val Ala 450 87453PRTVibrio fluvialis 87Met Asn Lys
Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 1 5 10 15 Tyr
Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 20 25
30 Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg
35 40 45 Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly
Phe Asp 50 55 60 His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr
Glu Arg Phe Pro 65 70 75 80 Gly Tyr His Ala Phe Phe Gly Arg Met Ser
Asp Gln Thr Val Met Leu 85 90 95 Ser Glu Lys Leu Val Glu Val Ser
Pro Phe Asp Ser Gly Arg Val Phe 100 105 110 Tyr Thr Asn Ser Gly Ser
Glu Ala Asn Asp Thr Met Val Lys Met Leu 115 120 125 Trp Phe Leu His
Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 130 135 140 Thr Arg
Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 145 150 155
160 Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe
165 170 175 Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu
Gly Glu 180 185 190 Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu
Leu Glu Glu Thr 195 200 205 Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala
Gly Phe Phe Ala Glu Pro 210 215 220 Val Met Gly Ala Gly Gly Val Ile
Pro Pro Ala Lys Gly Tyr Phe Gln 225 230 235 240 Ala Ile Leu Pro Ile
Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 245 250 255 Glu Val Ile
Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 260 265 270 Thr
Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 275 280
285 Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser
290 295 300 Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro
His Gly 305 310 315 320 Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala
Ile Ala Leu Lys Ala 325 330 335 Ile Asp Val Val Met Asn Glu Gly Leu
Ala Glu Asn Val Arg Arg Leu 340 345 350 Ala Pro Arg Phe Glu Glu Arg
Leu Lys His Ile Ala Glu Arg Pro Asn 355 360 365 Ile Gly Glu Tyr Arg
Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 370 375 380 Lys Asp Lys
Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 385 390 395 400
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 405
410 415 Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu
Ala 420 425 430 Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu
Asp Lys Val 435 440 445 Phe Ala Glu Val Ala 450
881362DNAArtificialVibrio fluvialis JS17 omega-aminotransferase
codon optimised gene 88atgaataaac cacagtcttg ggaagctcgt gctgaaacct
atagcctgta cggctttacc 60gatatgccgt ctctgcacca gcgtggtact gtagtggtaa
cgcacggtga gggcccgtac 120atcgtggacg ttaatggccg ccgttacctg
gatgcaaaca gcggcctgtg gaacatggtt 180gcgggcttcg accacaaagg
cctgatcgat gccgcaaaag cgcagtacga acgcttcccg 240ggttatcacg
cgttctttgg ccgtatgagc gaccagactg tgatgctgag cgaaaaactg
300gttgaagtgt ccccgttcga tagcggtcgt gtcttttaca ctaactctgg
cagcgaggct 360aacgatacca tggttaagat gctgtggttc ctgcacgcag
cggaaggcaa acctcagaaa 420cgtaaaattc tgacccgttg gaacgcttat
cacggtgtga ctgctgtttc cgcatctatg 480accggtaaac cgtataacag
cgtgttcggt ctgccgctgc ctggcttcgt gcatctgacc 540tgcccgcact
actggcgtta tggtgaggaa ggcgaaactg aggaacagtt cgtggcgcgt
600ctggctcgtg aactggaaga aaccattcaa cgcgaaggtg cagatactat
cgcgggcttc 660tttgcggagc ctgttatggg tgccggcggt gtgattccgc
cggcgaaggg ctatttccag 720gcaatcctgc cgatcctgcg caagtacgac
attccggtta tttctgacga agtgatctgc 780ggcttcggcc gcaccggtaa
cacctggggc tgcgtgacgt atgacttcac tccggacgca 840atcattagct
ctaaaaacct gactgcgggt ttcttcccta tgggcgccgt aatcctgggc
900ccagaactgt ctaagcgcct ggaaaccgcc atcgaggcaa tcgaagagtt
cccgcacggt 960ttcactgcta gcggccatcc ggtaggctgc gcaatcgcgc
tgaaggcgat cgatgttgtc 1020atgaacgagg gcctggcgga aaacgtgcgc
cgcctggcgc cgcgttttga agaacgtctg 1080aaacacattg ctgagcgccc
gaacattggc gaatatcgcg gcatcggttt catgtgggcc 1140ctggaagcag
ttaaagataa agctagcaag accccgttcg acggcaacct gtccgtgagc
1200gaacgtatcg ctaatacctg tacggacctg ggtctgatct gccgtccgct
gggtcagtcc 1260gtagttctgt gcccaccatt tatcctgacc gaagcgcaga
tggatgaaat gttcgataaa 1320ctggagaaag ctctggataa agtgttcgct
gaagtcgcgt aa 1362891350DNABacillus
weihenstephanensisCDS(1)..(1350) 89gtg caa gcg acg gag caa aca caa
agt ttg aaa aaa aca gat gaa aag 48Val Gln Ala Thr Glu Gln Thr Gln
Ser Leu Lys Lys Thr Asp Glu Lys 1 5 10 15 tac ctt tgg cat gcg atg
aga gga gca gcc cct agt cca acg aat tta 96Tyr Leu Trp His Ala Met
Arg Gly Ala Ala Pro Ser Pro Thr Asn Leu 20 25 30 att atc aca aaa
gca gaa ggg gca tgg gtg acg gat att gat gga aac 144Ile Ile Thr Lys
Ala Glu Gly Ala Trp Val Thr Asp Ile Asp Gly Asn 35 40 45 cgt tat
tta gac ggt atg tcc ggt ctt tgg tgc gtg aat gtt ggg tat 192Arg Tyr
Leu Asp Gly Met Ser Gly Leu Trp Cys Val Asn Val Gly Tyr 50 55 60
ggt cga aaa gaa ctt gca aga gcg gcg ttt gaa cag ctt gaa gaa atg
240Gly Arg Lys Glu Leu Ala Arg Ala Ala Phe Glu Gln Leu Glu Glu Met
65 70 75 80 ccg tat ttc cct ctg act caa agt cat gtt cct gct att aaa
tta gca 288Pro Tyr Phe Pro Leu Thr Gln Ser His Val Pro Ala Ile Lys
Leu Ala 85 90 95 gaa aaa ttg aat gaa tgg ctt gat gat gaa tac gtc
att ttc ttt tct 336Glu Lys Leu Asn Glu Trp Leu Asp Asp Glu Tyr Val
Ile Phe Phe Ser 100 105 110 aac agt gga tcg gaa gcg aat gaa aca gca
ttt aaa att gct cgt caa 384Asn Ser Gly Ser Glu Ala Asn Glu Thr Ala
Phe Lys Ile Ala Arg Gln 115 120 125 tat cat caa caa aaa ggt gat cat
gga cgc tat aag ttt att tcc cgc 432Tyr His Gln Gln Lys Gly Asp His
Gly Arg Tyr Lys Phe Ile Ser Arg 130 135 140 tac cgc gct tat cac ggt
aac tca atg gga gct ctt gca gca aca ggt 480Tyr Arg Ala Tyr His Gly
Asn Ser Met Gly Ala Leu Ala Ala Thr Gly 145 150 155 160 caa gca cag
cga aag tat aaa tat gaa cca ctc ggg caa gga ttc ctg 528Gln Ala Gln
Arg Lys Tyr Lys Tyr Glu Pro Leu Gly Gln Gly Phe Leu 165 170 175 cat
gta gca ccg cct gat acg tat cga aat cca gag gat gtt cat aca 576His
Val Ala Pro Pro Asp Thr Tyr Arg Asn Pro Glu Asp Val His Thr 180 185
190 ctg gca agt gct gag gaa atc gat cgt gtc atg aca tgg gag tta agc
624Leu Ala Ser Ala Glu Glu Ile Asp Arg Val Met Thr Trp Glu Leu Ser
195 200 205 caa aca gta gcc ggt gtg att atg gag cca atc att act ggg
ggc gga 672Gln Thr Val Ala Gly Val Ile Met Glu Pro Ile Ile Thr Gly
Gly Gly 210 215 220 att tta atg cct cct gat gga tat atg gga aaa gta
aaa gaa att tgc 720Ile Leu Met Pro Pro Asp Gly Tyr Met Gly Lys Val
Lys Glu Ile Cys 225 230 235 240 gag aag cac ggt gcg ttg ctc att tgt
gat gaa gtt ata tgt gga ttt 768Glu Lys His Gly Ala Leu Leu Ile Cys
Asp Glu Val Ile Cys Gly Phe 245 250 255 ggc cgg aca ggg aag cca ttt
gga ttt atg aat tat ggc gtc aaa cca 816Gly Arg Thr Gly Lys Pro Phe
Gly Phe Met Asn Tyr Gly Val Lys Pro 260 265 270 gat atc att aca atg
gca aaa ggt att aca agt gcg tat ctt cct ttg 864Asp Ile Ile Thr Met
Ala Lys Gly Ile Thr Ser Ala Tyr Leu Pro Leu 275 280 285 tca gca aca
gca gtt aga cga gag gtt tat gag gca ttc gta ggt agt 912Ser Ala Thr
Ala Val Arg Arg Glu Val Tyr Glu Ala Phe Val Gly Ser 290 295 300 gat
gat tat gat cgc ttc cgc cat gta aat acg ttc gga ggg aat cct 960Asp
Asp Tyr Asp Arg Phe Arg His Val Asn Thr Phe Gly Gly Asn Pro 305 310
315 320 gct gct tgc gct tta gct ttg aag aat tta gaa att atg gag aat
gag
1008Ala Ala Cys Ala Leu Ala Leu Lys Asn Leu Glu Ile Met Glu Asn Glu
325 330 335 aaa ctc att gaa cgt tcc aaa gaa ttg ggt gaa cga ctg tta
tat gag 1056Lys Leu Ile Glu Arg Ser Lys Glu Leu Gly Glu Arg Leu Leu
Tyr Glu 340 345 350 cta gag gat gta aaa gag cat cca aac gta ggg gat
gtt cgc gga aag 1104Leu Glu Asp Val Lys Glu His Pro Asn Val Gly Asp
Val Arg Gly Lys 355 360 365 ggc ctt ctt tta ggc att gaa cta gtg gaa
gat aag caa aca aaa gaa 1152Gly Leu Leu Leu Gly Ile Glu Leu Val Glu
Asp Lys Gln Thr Lys Glu 370 375 380 ccg gct tcc att gaa aag atg aac
aaa gtc atc aat gct tgt aaa gaa 1200Pro Ala Ser Ile Glu Lys Met Asn
Lys Val Ile Asn Ala Cys Lys Glu 385 390 395 400 aaa ggt cta att att
ggt aaa aat ggt gac act gtc gca ggt tac aat 1248Lys Gly Leu Ile Ile
Gly Lys Asn Gly Asp Thr Val Ala Gly Tyr Asn 405 410 415 aat att ttg
cag ctt gca cct cca tta agc atc aca gag gaa gac ttt 1296Asn Ile Leu
Gln Leu Ala Pro Pro Leu Ser Ile Thr Glu Glu Asp Phe 420 425 430 act
ttt atc gtt aaa aca atg aaa gaa tgt tta tcc cgc att aac ggg 1344Thr
Phe Ile Val Lys Thr Met Lys Glu Cys Leu Ser Arg Ile Asn Gly 435 440
445 cag taa 1350Gln 90449PRTBacillus weihenstephanensis 90Val Gln
Ala Thr Glu Gln Thr Gln Ser Leu Lys Lys Thr Asp Glu Lys 1 5 10 15
Tyr Leu Trp His Ala Met Arg Gly Ala Ala Pro Ser Pro Thr Asn Leu 20
25 30 Ile Ile Thr Lys Ala Glu Gly Ala Trp Val Thr Asp Ile Asp Gly
Asn 35 40 45 Arg Tyr Leu Asp Gly Met Ser Gly Leu Trp Cys Val Asn
Val Gly Tyr 50 55 60 Gly Arg Lys Glu Leu Ala Arg Ala Ala Phe Glu
Gln Leu Glu Glu Met 65 70 75 80 Pro Tyr Phe Pro Leu Thr Gln Ser His
Val Pro Ala Ile Lys Leu Ala 85 90 95 Glu Lys Leu Asn Glu Trp Leu
Asp Asp Glu Tyr Val Ile Phe Phe Ser 100 105 110 Asn Ser Gly Ser Glu
Ala Asn Glu Thr Ala Phe Lys Ile Ala Arg Gln 115 120 125 Tyr His Gln
Gln Lys Gly Asp His Gly Arg Tyr Lys Phe Ile Ser Arg 130 135 140 Tyr
Arg Ala Tyr His Gly Asn Ser Met Gly Ala Leu Ala Ala Thr Gly 145 150
155 160 Gln Ala Gln Arg Lys Tyr Lys Tyr Glu Pro Leu Gly Gln Gly Phe
Leu 165 170 175 His Val Ala Pro Pro Asp Thr Tyr Arg Asn Pro Glu Asp
Val His Thr 180 185 190 Leu Ala Ser Ala Glu Glu Ile Asp Arg Val Met
Thr Trp Glu Leu Ser 195 200 205 Gln Thr Val Ala Gly Val Ile Met Glu
Pro Ile Ile Thr Gly Gly Gly 210 215 220 Ile Leu Met Pro Pro Asp Gly
Tyr Met Gly Lys Val Lys Glu Ile Cys 225 230 235 240 Glu Lys His Gly
Ala Leu Leu Ile Cys Asp Glu Val Ile Cys Gly Phe 245 250 255 Gly Arg
Thr Gly Lys Pro Phe Gly Phe Met Asn Tyr Gly Val Lys Pro 260 265 270
Asp Ile Ile Thr Met Ala Lys Gly Ile Thr Ser Ala Tyr Leu Pro Leu 275
280 285 Ser Ala Thr Ala Val Arg Arg Glu Val Tyr Glu Ala Phe Val Gly
Ser 290 295 300 Asp Asp Tyr Asp Arg Phe Arg His Val Asn Thr Phe Gly
Gly Asn Pro 305 310 315 320 Ala Ala Cys Ala Leu Ala Leu Lys Asn Leu
Glu Ile Met Glu Asn Glu 325 330 335 Lys Leu Ile Glu Arg Ser Lys Glu
Leu Gly Glu Arg Leu Leu Tyr Glu 340 345 350 Leu Glu Asp Val Lys Glu
His Pro Asn Val Gly Asp Val Arg Gly Lys 355 360 365 Gly Leu Leu Leu
Gly Ile Glu Leu Val Glu Asp Lys Gln Thr Lys Glu 370 375 380 Pro Ala
Ser Ile Glu Lys Met Asn Lys Val Ile Asn Ala Cys Lys Glu 385 390 395
400 Lys Gly Leu Ile Ile Gly Lys Asn Gly Asp Thr Val Ala Gly Tyr Asn
405 410 415 Asn Ile Leu Gln Leu Ala Pro Pro Leu Ser Ile Thr Glu Glu
Asp Phe 420 425 430 Thr Phe Ile Val Lys Thr Met Lys Glu Cys Leu Ser
Arg Ile Asn Gly 435 440 445 Gln 911350DNAArtificialB.
weihenstephanensis KBAB4 aminotransferase codon-optimised gene
91atgcaggcta ccgaacaaac ccaatctctg aaaaagactg acgaaaaata tctgtggcac
60gcgatgcgcg gtgcagctcc gtctccgacc aacctgatta ttaccaaagc tgaaggcgcg
120tgggtgaccg acattgacgg taaccgttat ctggatggca tgagcggcct
gtggtgtgtt 180aatgtcggtt atggccgtaa ggagctggcg cgcgcggcat
ttgaacaact ggaagaaatg 240ccgtacttcc cgctgactca aagccatgtg
ccggctatca aactggcgga aaaactgaac 300gaatggctgg acgacgaata
cgtgattttc ttctctaatt ctggctccga agcaaacgaa 360accgcattca
aaatcgcccg tcaatatcac cagcagaaag gtgaccacgg ccgctataaa
420ttcatcagcc gttatcgtgc ataccatggt aattctatgg gtgcgctggc
tgctaccggt 480caggctcagc gcaaatacaa gtacgaaccg ctgggtcagg
gttttctgca cgttgcacca 540ccggatacct accgtaaccc ggaagacgtc
cacaccctgg cttctgccga agaaatcgat 600cgtgttatga cctgggagct
gtcccagact gttgcgggtg ttatcatgga acctattatt 660accggtggtg
gcattctgat gccgccggac ggttatatgg gtaaagtcaa ggaaatctgc
720gaaaaacacg gcgcgctgct gatctgcgat gaagttatct gtggcttcgg
tcgcaccggc 780aaaccatttg gcttcatgaa ttatggcgta aaacctgaca
ttattaccat ggctaaaggc 840attacttccg cttatctgcc gctgagcgcg
accgcagttc gccgcgaagt ttatgaagcg 900tttgttggtt ctgatgatta
cgaccgtttc cgtcatgtaa acacgtttgg cggtaaccca 960gcggcatgtg
cgctggcgct gaaaaacctg gaaatcatgg aaaacgaaaa gctgatcgaa
1020cgtagcaaag aactgggtga acgtctgctg tacgaactgg aagatgtcaa
agaacacccg 1080aacgtgggcg atgttcgcgg taaaggcctg ctgctgggta
ttgaactggt tgaagacaaa 1140cagaccaagg aaccggcttc cattgaaaag
atgaacaaag tgattaacgc gtgcaaagag 1200aaaggcctga tcattggtaa
gaacggtgat accgtggcag gttataacaa cattctgcag 1260ctggcgccgc
ctctgagcat cactgaagaa gatttcacct tcatcgtcaa aactatgaag
1320gagtgcctga gccgcatcaa tggtcagtaa 135092255PRTSaccharomyces
cerevisiae 92Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val
Ile Asp Tyr 1 5 10 15 Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr
Gly Val Val Thr Asp 20 25 30 Gly Val Lys His Ser Met Asn Pro Phe
Cys Glu Ile Ala Val Glu Glu 35 40 45 Ala Val Arg Leu Lys Glu Lys
Lys Leu Val Lys Glu Val Ile Ala Val 50 55 60 Ser Cys Gly Pro Ala
Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala 65 70 75 80 Met Gly Ala
Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala 85 90 95 Glu
Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala 100 105
110 Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
115 120 125 Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu
Asp Trp 130 135 140 Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu
Gly Asp Lys Leu 145 150 155 160 Lys Val Glu Arg Glu Ile Asp Gly Gly
Leu Glu Thr Leu Arg Leu Lys 165 170 175 Leu Pro Ala Val Val Thr Ala
Asp Leu Arg Leu Asn Glu Pro Arg Tyr 180 185 190 Ala Thr Leu Pro Asn
Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val 195 200 205 Ile Lys Pro
Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val 210 215 220 Ile
Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu 225 230
235 240 Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
245 250 255 93860DNAartificialMicroscilla marina 93ggtaccggat
ccctaacagg aggaattaac catggtccag aaagacctgt tcaaagacaa 60agttgttctg
gtaactggcg gtcgttctgg tatcggttac gcaatttctc agatgatgct
120ggaactgggt gcgaaagttg ttatcgcttc tcgcaaagag gatctgctga
aacaggctgc 180tgaagaactg tctcagtacg gtgaatgctc ctacctggct
tgcgacatcc gtgaatctga 240ccagcgtact gcgctgatgg agaagatcaa
agctgacaac ggtcgtctgg atatcctggt 300taacaacgct ggcggtcagt
tcccggcacc ggcagaaacc atctctgaaa acggctggga 360cgctgttatc
aacaacaacc tgaacggtac tttccacatg tcctctctga tggcgcgtca
420cttcttcatc ccgcagaaag aaggttgcat catcaacatc atcgctaaca
tctaccgcgg 480tttcccgtct atggttcaca ccggtgcagc acgtgctggc
gttgaaaacc tgaccaaaac 540tctggcggtt gagtggggcg actacaacat
ccgcgttaac gcgattgctc cgggtactat 600cgaatcttcc ggtctggata
cttacccgaa gccggtacag gacatcctgg gtgaagcgcg 660tgctgcagta
ccactgaaac gcttcggtac tgttactgaa atcgctaaca ccacttgctt
720cctggcttct ccgctggctt cttacatctc cggtgtttct ctgtacgttg
acggtgcaca 780gcacctgaac ggtggtgacc cgatgaagct gactcgcctg
atgcgtgcat tcaccaagtc 840tcgtgagctc taataagctt
86094273PRTMicroscilla marina 94Met Val Gln Lys Asp Leu Phe Lys Asp
Lys Val Val Leu Val Thr Gly 1 5 10 15 Gly Arg Ser Gly Ile Gly Tyr
Ala Ile Ser Gln Met Met Leu Glu Leu 20 25 30 Gly Ala Lys Val Val
Ile Ala Ser Arg Lys Glu Asp Leu Leu Lys Gln 35 40 45 Ala Ala Glu
Glu Leu Ser Gln Tyr Gly Glu Cys Ser Tyr Leu Ala Cys 50 55 60 Asp
Ile Arg Glu Ser Asp Gln Arg Thr Ala Leu Met Glu Lys Ile Lys 65 70
75 80 Ala Asp Asn Gly Arg Leu Asp Ile Leu Val Asn Asn Ala Gly Gly
Gln 85 90 95 Phe Pro Ala Pro Ala Glu Thr Ile Ser Glu Asn Gly Trp
Asp Ala Val 100 105 110 Ile Asn Asn Asn Leu Asn Gly Thr Phe His Met
Ser Ser Leu Met Ala 115 120 125 Arg His Phe Phe Ile Pro Gln Lys Glu
Gly Cys Ile Ile Asn Ile Ile 130 135 140 Ala Asn Ile Tyr Arg Gly Phe
Pro Ser Met Val His Thr Gly Ala Ala 145 150 155 160 Arg Ala Gly Val
Glu Asn Leu Thr Lys Thr Leu Ala Val Glu Trp Gly 165 170 175 Asp Tyr
Asn Ile Arg Val Asn Ala Ile Ala Pro Gly Thr Ile Glu Ser 180 185 190
Ser Gly Leu Asp Thr Tyr Pro Lys Pro Val Gln Asp Ile Leu Gly Glu 195
200 205 Ala Arg Ala Ala Val Pro Leu Lys Arg Phe Gly Thr Val Thr Glu
Ile 210 215 220 Ala Asn Thr Thr Cys Phe Leu Ala Ser Pro Leu Ala Ser
Tyr Ile Ser 225 230 235 240 Gly Val Ser Leu Tyr Val Asp Gly Ala Gln
His Leu Asn Gly Gly Asp 245 250 255 Pro Met Lys Leu Thr Arg Leu Met
Arg Ala Phe Thr Lys Ser Arg Glu 260 265 270 Thr
951241DNAArtificialClostridium beijerinckii 95ggtaccggat ccctaacagg
aggaattaat catgatcttc aagccggaac tgatcaaagg 60tatcgctaaa acttctcacc
cgtacggttg ccgtaaagaa gttctgaacc agatcgaata 120ctgcaaaaac
gctaagcagt tccacggtcc gaagaaagtt ctgatcatcg gtgcttcttc
180cggtttcggt ctggcaactc gcatttctct ggcgttcggt ggtgcgaaag
cagacaccat 240cggtgtttct ttcgaaaccg gtatcactga ccgccgtact
ggtactgcag gctggtacaa 300caacatcttc ttcaaagagt tcgcagaaaa
agaaggtctg attgctaaaa acttcatcgg 360tgacgcattc tctgacgaag
ttaaagaaaa cgttatcaaa tacatcaaaa acgagttcgg 420taagatcgat
ctgctgatct actctctggc ttctccgcgc cgtaaagatc cgaaaaccgg
480taacatctac gactccactc tgaaaaccac ttctggcgag ttccagggcc
caaccatcga 540catggaaact gacgaactgg ttactaccaa agttaactcc
gcaactgaca aagaaatcga 600agcgaccaag aaagtaatgg gtggtgaaga
ttggtctgaa tggtgcaaac tgctgctgga 660aaacgactgc ctgtctgaca
aagctatcac tatctcttac tcttacatcg gtgcttctcg 720cacttacaaa
atctaccgtg aaggtactat cggtgaagcg aagcgtcacc tggaaaacac
780tgcgattcag atcgacaaag aatggcagaa gaagatcaac ggtaaagcat
tcgtttctgt 840taacaaagca atcgttacca aggcttctgc ttacatcccg
tctttctctc tgtacgctgc 900tgttctgtac aaagtaatga aagaaaaaaa
tctgcacgaa aactgcatca tgcagatgca 960gcgtatgttc gctgacaaaa
tctacgctga aaatctgctg gagttcgacg actccggtcg 1020tctgcgtatg
gacgactggg aactgcgtga agatgtacag tctgaagtta acgaactgtg
1080ggaaaaaatc actccggata acttcaagat cctgtctgac tacgacggtt
acaagaaaga 1140gttcatgcag ctgaacggct tcgaaatcga cggtgttaac
tactctgaag atatcgacat 1200cgaagcgctg aagcgcctgg aaccggagct
ctaataagct t 124196400PRTClostridium beijerinckii 96Met Ile Phe Lys
Pro Glu Leu Ile Lys Gly Ile Ala Lys Thr Ser His 1 5 10 15 Pro Tyr
Gly Cys Arg Lys Glu Val Leu Asn Gln Ile Glu Tyr Cys Lys 20 25 30
Asn Ala Lys Gln Phe His Gly Pro Lys Lys Val Leu Ile Ile Gly Ala 35
40 45 Ser Ser Gly Phe Gly Leu Ala Thr Arg Ile Ser Leu Ala Phe Gly
Gly 50 55 60 Ala Lys Ala Asp Thr Ile Gly Val Ser Phe Glu Thr Gly
Ile Thr Asp 65 70 75 80 Arg Arg Thr Gly Thr Ala Gly Trp Tyr Asn Asn
Ile Phe Phe Lys Glu 85 90 95 Phe Ala Glu Lys Glu Gly Leu Ile Ala
Lys Asn Phe Ile Gly Asp Ala 100 105 110 Phe Ser Asp Glu Val Lys Glu
Asn Val Ile Lys Tyr Ile Lys Asn Glu 115 120 125 Phe Gly Lys Ile Asp
Leu Leu Ile Tyr Ser Leu Ala Ser Pro Arg Arg 130 135 140 Lys Asp Pro
Lys Thr Gly Asn Ile Tyr Asp Ser Thr Leu Lys Thr Thr 145 150 155 160
Ser Gly Glu Phe Gln Gly Pro Thr Ile Asp Met Glu Thr Asp Glu Leu 165
170 175 Val Thr Thr Lys Val Asn Ser Ala Thr Asp Lys Glu Ile Glu Ala
Thr 180 185 190 Lys Lys Val Met Gly Gly Glu Asp Trp Ser Glu Trp Cys
Lys Leu Leu 195 200 205 Leu Glu Asn Asp Cys Leu Ser Asp Lys Ala Ile
Thr Ile Ser Tyr Ser 210 215 220 Tyr Ile Gly Ala Ser Arg Thr Tyr Lys
Ile Tyr Arg Glu Gly Thr Ile 225 230 235 240 Gly Glu Ala Lys Arg His
Leu Glu Asn Thr Ala Ile Gln Ile Asp Lys 245 250 255 Glu Trp Gln Lys
Lys Ile Asn Gly Lys Ala Phe Val Ser Val Asn Lys 260 265 270 Ala Ile
Val Thr Lys Ala Ser Ala Tyr Ile Pro Ser Phe Ser Leu Tyr 275 280 285
Ala Ala Val Leu Tyr Lys Val Met Lys Glu Lys Asn Leu His Glu Asn 290
295 300 Cys Ile Met Gln Met Gln Arg Met Phe Ala Asp Lys Ile Tyr Ala
Glu 305 310 315 320 Asn Leu Leu Glu Phe Asp Asp Ser Gly Arg Leu Arg
Met Asp Asp Trp 325 330 335 Glu Leu Arg Glu Asp Val Gln Ser Glu Val
Asn Glu Leu Trp Glu Lys 340 345 350 Ile Thr Pro Asp Asn Phe Lys Ile
Leu Ser Asp Tyr Asp Gly Tyr Lys 355 360 365 Lys Glu Phe Met Gln Leu
Asn Gly Phe Glu Ile Asp Gly Val Asn Tyr 370 375 380 Ser Glu Asp Ile
Asp Ile Glu Ala Leu Lys Arg Leu Glu Pro Glu Thr 385 390 395 400
971238DNAArtificialAeromonas hydrophila subsp. hydrophila
97ggtaccggat ccctaacagg aggaattaat catgatcatc aagccgaaag ttcgtggctt
60catctgcacc actactcacc cggttggttg cgaagctaac gttcgtcgtc agatcgctta
120caccaaagcg aaaggtacta tcgaaaacgg tccgaagaaa gttctggtta
tcggtgcttc 180taccggttac ggtctggctt ctcgcattgc tgctgcattc
ggttctggtg cggcaactct 240gggcgtattc ttcgaaaaag cgggttctga
aaccaaaact gcaactgctg gctggtacaa 300ctccgcagca ttcgacaaag
cagctaaaga agcgggtctg tacgctaaat ctatcaacgg 360tgacgcattc
tctaacgaat gccgcgctaa agttatcgaa ctgatcaagc aggacctggg
420tcagatcgac ctggttgttt actctctggc ttctccggta cgtaagctgc
cggataccgg 480tgaagttgtt cgttctgcac tgaaaccgat cggtgaagtt
tacaccacta ctgctatcga 540caccaacaaa gaccagatca tcactgcaac
cgttgagccg gctaacgaag aagaaatcca 600gaacaccatc accgtaatgg
gtggtcagga ctgggaactg tggatggctg cgctgcgcga 660tgctggcgta
ctggcagacg gtgcgaagtc tgttgcttac tcttacatcg gtactgacct
720gacctggcca atctactggc acggtactct gggtcgtgcg aaagaagatt
tggaccgcgc 780tgcagctgct atccgcggtg acctggcagg caaaggtggt
actgcgcacg ttgctgtact 840gaaatctgtt gttactcagg cttcttctgc
gattccggta atgccgctgt acatctctat 900ggcattcaag attatgaaag
agaaaggtat ccacgaaggt tgcatggaac aggttgaccg 960tatgatgcgt
actcgtctgt acgctgcaga catggcgctg gatgaccagg cgcgtatccg
1020tatggacgac tgggaactgc gtgaagatgt tcagcagact tgccgcgacc
tgtggccgtc 1080tatcacttct gaaaacctgt gcgaactgac tgactacacc
ggttacaagc aggagttcct 1140gcgtctgttc ggtttcggtc tggaagaagt
tgactacgac gctgacgtta acccggacgt 1200taagttcgac gttgttgaac
tagagctcta ataagctt 123898399PRTAeromonas hydrophila subsp.
hydrophila 98Met Ile Ile Lys Pro Lys Val Arg Gly Phe Ile Cys Thr
Thr Thr His 1 5 10 15 Pro Val Gly Cys Glu Ala Asn Val Arg Arg Gln
Ile Ala Tyr Thr Lys 20 25 30 Ala Lys Gly Thr Ile Glu Asn Gly Pro
Lys Lys Val Leu Val Ile Gly 35 40 45 Ala Ser Thr Gly Tyr Gly Leu
Ala Ser Arg Ile Ala Ala Ala Phe Gly 50 55 60 Ser Gly Ala Ala Thr
Leu Gly Val Phe Phe Glu Lys Ala Gly Ser Glu 65 70 75 80 Thr Lys Thr
Ala Thr Ala Gly Trp Tyr Asn Ser Ala Ala Phe Asp Lys 85 90 95 Ala
Ala Lys Glu Ala Gly Leu Tyr Ala Lys Ser Ile Asn Gly Asp Ala 100 105
110 Phe Ser Asn Glu Cys Arg Ala Lys Val Ile Glu Leu Ile Lys Gln Asp
115 120 125 Leu Gly Gln Ile Asp Leu Val Val Tyr Ser Leu Ala Ser Pro
Val Arg 130 135 140 Lys Leu Pro Asp Thr Gly Glu Val Val Arg Ser Ala
Leu Lys Pro Ile 145 150 155 160 Gly Glu Val Tyr Thr Thr Thr Ala Ile
Asp Thr Asn Lys Asp Gln Ile 165 170 175 Ile Thr Ala Thr Val Glu Pro
Ala Asn Glu Glu Glu Ile Gln Asn Thr 180 185 190 Ile Thr Val Met Gly
Gly Gln Asp Trp Glu Leu Trp Met Ala Ala Leu 195 200 205 Arg Asp Ala
Gly Val Leu Ala Asp Gly Ala Lys Ser Val Ala Tyr Ser 210 215 220 Tyr
Ile Gly Thr Asp Leu Thr Trp Pro Ile Tyr Trp His Gly Thr Leu 225 230
235 240 Gly Arg Ala Lys Glu Asp Leu Asp Arg Ala Ala Ala Ala Ile Arg
Gly 245 250 255 Asp Leu Ala Gly Lys Gly Gly Thr Ala His Val Ala Val
Leu Lys Ser 260 265 270 Val Val Thr Gln Ala Ser Ser Ala Ile Pro Val
Met Pro Leu Tyr Ile 275 280 285 Ser Met Ala Phe Lys Ile Met Lys Glu
Lys Gly Ile His Glu Gly Cys 290 295 300 Met Glu Gln Val Asp Arg Met
Met Arg Thr Arg Leu Tyr Ala Ala Asp 305 310 315 320 Met Ala Leu Asp
Asp Gln Ala Arg Ile Arg Met Asp Asp Trp Glu Leu 325 330 335 Arg Glu
Asp Val Gln Gln Thr Cys Arg Asp Leu Trp Pro Ser Ile Thr 340 345 350
Ser Glu Asn Leu Cys Glu Leu Thr Asp Tyr Thr Gly Tyr Lys Gln Glu 355
360 365 Phe Leu Arg Leu Phe Gly Phe Gly Leu Glu Glu Val Asp Tyr Asp
Ala 370 375 380 Asp Val Asn Pro Asp Val Lys Phe Asp Val Val Glu Leu
Glu Thr 385 390 395 991142DNAArtificialYarrowia lipolytica
99ggtaccggat ccctaacagg aggaattaac catggccggc ttcggtactc cgtctttcgg
60tctgcgcttc aactccgttg gtcgtgcatt cgtattctct cagactggcg aaccgaaaga
120cgttattcag gtactggaat acccaatcga aaaaccgctg gaaaaccagg
ttctgctgaa 180atctctgggc ttcactatca acccggctga catcaaccag
ctggaaggtg tttacccgtc 240tgtaccgccg aaatctgtac agatcaacaa
cgaagatgct gctatcggtg gtaacgaagg 300tctgttccag gttctggacc
cgggtgctaa atctggtctg aagaaaggcg actgggtact 360gccgcgtaaa
acttgcttcg gcacctggcg ttctcacgcg ctggttgaag ctgataccgt
420tgttaagatc gacaacaccg acctgaccaa agttcaggca actaccgttt
ctgttaaccc 480gtctactgct tacgaaatgc tgaaagacct gaaagaaggt
gactggttca tccagaacgg 540tggtaactcc ggtgttggtc gtgctgcgat
tcagatcggt cacatccgcg gtctgaaatc 600tatctccgtt gttcgtgacc
gtccggatct ggaagttctg aagaaagaac tgactgacct 660gggtgcaact
cacgttatca ctgaagaaga agcgtctgac aaactgttct ccaagcagat
720caaatcctgg actggcggta aaatcaagct ggcactgaac tgcatcggtg
gtaaatctgc 780aacttccatc atgcgtcagc tgggtgctgg cggttctatc
gttacttacg gtggtatgtc 840caagaagccg ctgactttcc cgactggtcc
gttcatcttc aaagacatca ctgcgaaagg 900ttactggctg actcgctggg
ctgacaagca cccggaagaa aaagcgaaaa ctatcgaaaa 960catcttcaaa
ttctaccgcg agaagaaatt cgttgctccg ccagttaaca tctccactct
1020ggacttctct aaaggtaacg acgttgttct gtctgagttc ctggatgcac
tgggtaaagc 1080acagaaaggt ggtggtaaga agcagctggt acagtgggtt
gaatacgagc tctaataagc 1140tt 1142100367PRTYarrowia lipolytica
100Met Ala Gly Phe Gly Thr Pro Ser Phe Gly Leu Arg Phe Asn Ser Val
1 5 10 15 Gly Arg Ala Phe Val Phe Ser Gln Thr Gly Glu Pro Lys Asp
Val Ile 20 25 30 Gln Val Leu Glu Tyr Pro Ile Glu Lys Pro Leu Glu
Asn Gln Val Leu 35 40 45 Leu Lys Ser Leu Gly Phe Thr Ile Asn Pro
Ala Asp Ile Asn Gln Leu 50 55 60 Glu Gly Val Tyr Pro Ser Val Pro
Pro Lys Ser Val Gln Ile Asn Asn 65 70 75 80 Glu Asp Ala Ala Ile Gly
Gly Asn Glu Gly Leu Phe Gln Val Leu Asp 85 90 95 Pro Gly Ala Lys
Ser Gly Leu Lys Lys Gly Asp Trp Val Leu Pro Arg 100 105 110 Lys Thr
Cys Phe Gly Thr Trp Arg Ser His Ala Leu Val Glu Ala Asp 115 120 125
Thr Val Val Lys Ile Asp Asn Thr Asp Leu Thr Lys Val Gln Ala Thr 130
135 140 Thr Val Ser Val Asn Pro Ser Thr Ala Tyr Glu Met Leu Lys Asp
Leu 145 150 155 160 Lys Glu Gly Asp Trp Phe Ile Gln Asn Gly Gly Asn
Ser Gly Val Gly 165 170 175 Arg Ala Ala Ile Gln Ile Gly His Ile Arg
Gly Leu Lys Ser Ile Ser 180 185 190 Val Val Arg Asp Arg Pro Asp Leu
Glu Val Leu Lys Lys Glu Leu Thr 195 200 205 Asp Leu Gly Ala Thr His
Val Ile Thr Glu Glu Glu Ala Ser Asp Lys 210 215 220 Leu Phe Ser Lys
Gln Ile Lys Ser Trp Thr Gly Gly Lys Ile Lys Leu 225 230 235 240 Ala
Leu Asn Cys Ile Gly Gly Lys Ser Ala Thr Ser Ile Met Arg Gln 245 250
255 Leu Gly Ala Gly Gly Ser Ile Val Thr Tyr Gly Gly Met Ser Lys Lys
260 265 270 Pro Leu Thr Phe Pro Thr Gly Pro Phe Ile Phe Lys Asp Ile
Thr Ala 275 280 285 Lys Gly Tyr Trp Leu Thr Arg Trp Ala Asp Lys His
Pro Glu Glu Lys 290 295 300 Ala Lys Thr Ile Glu Asn Ile Phe Lys Phe
Tyr Arg Glu Lys Lys Phe 305 310 315 320 Val Ala Pro Pro Val Asn Ile
Ser Thr Leu Asp Phe Ser Lys Gly Asn 325 330 335 Asp Val Val Leu Ser
Glu Phe Leu Asp Ala Leu Gly Lys Ala Gln Lys 340 345 350 Gly Gly Gly
Lys Lys Gln Leu Val Gln Trp Val Glu Tyr Glu Thr 355 360 365
1011856DNAArtificialClostridium kluyveri 101ggtaccggat ccctaacagg
aggaattaac catggacctg gcagaataca aaggcgtatg 60ggtattcgct gaacagcgtg
acggtgaact gcagaaagtt gcgctgcagc tggttggtaa 120aggtcgtgaa
ctggctgaca ctctgggtgt tgaactgact gcggtactgc tgggttctga
180agttgatgac ctggcgaaag aactggttgc ttacggcgca gacaacgtac
tgtacgcaga 240ctctccgctg ctgaagcact acaccactga cggttacacc
aaagttatcg acgaactgat 300caaagagcgt aagccggaaa tcctgctgat
cggtgcgact ttcatcggtc gtgacctggg 360tccgcgcgtt gctggtcgcg
tattcaccgg tctgactgca gactgcaccg gtctggatat 420cgacgaagcg
accaagaacc tgatgatgac tcgtccggca ttcggtggta acctgatggc
480aactatcgct tgcgaaaaaa ctcgtccgca gatgtccacc gttcgtccgg
gcgtattcaa 540cgcactgccg cgcgacgctt cccgtactgg taagatcgaa
aaaatcgctg ctaacgttgc 600taaagacgac atccgtatcg aagttctgga
agttgttaag tctgctggcg acaccatcga 660catctctgaa gcagacgtta
tcgtttctgg tggtcgcggt ctgggtggtc cggacggctt 720caaagttctg
aaagaactgg ctgatctgct gggtggtact atcggtggtt ctcgcgctac
780catcgacgct ggctggatcg acaagtctta ccaggttggt cagactggta
aaaccgttcg 840tccgggtctg tacatcgctt gcggtatctc cggtcagatt
cagcacctgg caggcatgca 900ggattccggc ttcatcgttg ctatcaacaa
agacgaaaac gcaccgatga tgcaagttgc 960tgatctggcg attgttggtg
acctgtacaa agttgttcca gagttcgttg aacaggttaa 1020agcgctgaac
ttgtaataac tagtctaaca ggaggaatta atcatgaaga tcgttgtttg
1080cctgaaacag gttccggata ccactgaagt taagatcgac ccgaaaaccg
gtactctgat 1140ccgtgaaggc gtaccgtcta tcatcaaccc ggatgacaaa
aacgcgctgg aagaatccat 1200tgctctgaaa gagaaagttg gcggcaccgt
aactgttgtt tctatgggtc cgccacaggc 1260tgttgatgcg ctgcgtgaag
cgctggcaat gggtgctgac gaagcaatcc tggtatctga 1320ccgcgctttc
gctggtgctg acactcaggc aacttcttac gcactggcag gcgcactgaa
1380aaacctggaa tacgacctga ttttcgctgg tcgtcaggct atcgacggtg
acactgcaca 1440ggttggtccg cagatcgctg aaaaactggg tatcccgcag
atcacttacg ttgaaaaagt 1500tgacgttgac ggtgacactc tgaccgtaca
gcgtgcatgg gaagatggtt acgaagttgc 1560gaaaatcaaa actccgtgca
tgctgactgc tatcaaagag ctgaaccagc cgcgctacat 1620gaacatgaag
aacatcttcg aagtattcaa gaaagaagtt aaaatctggt ctgctgacga
1680cctggacgtt gacaaaaaca agctgggtct gaacggttcc tgcaccaaag
ttaagcgttc 1740tcacaccaaa gaagcgaaag gtgctggcga aatcgttaac
aagccgatca aagaagcggt 1800tgcttactcc atctccaagc tgcgtgaaaa
acacgttatc gagctctaat aagctt 1856102334PRTClostridium kluyveri
102Met Asp Leu Ala Glu Tyr Lys Gly Val Trp Val Phe Ala Glu Gln Arg
1 5 10 15 Asp Gly Glu Leu Gln Lys Val Ala Leu Gln Leu Val Gly Lys
Gly Arg 20 25 30 Glu Leu Ala Asp Thr Leu Gly Val Glu Leu Thr Ala
Val Leu Leu Gly 35 40 45 Ser Glu Val Asp Asp Leu Ala Lys Glu Leu
Val Ala Tyr Gly Ala Asp 50 55 60 Asn Val Leu Tyr Ala Asp Ser Pro
Leu Leu Lys His Tyr Thr Thr Asp 65 70 75 80 Gly Tyr Thr Lys Val Ile
Asp Glu Leu Ile Lys Glu Arg Lys Pro Glu 85 90 95 Ile Leu Leu Ile
Gly Ala Thr Phe Ile Gly Arg Asp Leu Gly Pro Arg 100 105 110 Val Ala
Gly Arg Val Phe Thr Gly Leu Thr Ala Asp Cys Thr Gly Leu 115 120 125
Asp Ile Asp Glu Ala Thr Lys Asn Leu Met Met Thr Arg Pro Ala Phe 130
135 140 Gly Gly Asn Leu Met Ala Thr Ile Ala Cys Glu Lys Thr Arg Pro
Gln 145 150 155 160 Met Ser Thr Val Arg Pro Gly Val Phe Asn Ala Leu
Pro Arg Asp Ala 165 170 175 Ser Arg Thr Gly Lys Ile Glu Lys Ile Ala
Ala Asn Val Ala Lys Asp 180 185 190 Asp Ile Arg Ile Glu Val Leu Glu
Val Val Lys Ser Ala Gly Asp Thr 195 200 205 Ile Asp Ile Ser Glu Ala
Asp Val Ile Val Ser Gly Gly Arg Gly Leu 210 215 220 Gly Gly Pro Asp
Gly Phe Lys Val Leu Lys Glu Leu Ala Asp Leu Leu 225 230 235 240 Gly
Gly Thr Ile Gly Gly Ser Arg Ala Thr Ile Asp Ala Gly Trp Ile 245 250
255 Asp Lys Ser Tyr Gln Val Gly Gln Thr Gly Lys Thr Val Arg Pro Gly
260 265 270 Leu Tyr Ile Ala Cys Gly Ile Ser Gly Gln Ile Gln His Leu
Ala Gly 275 280 285 Met Gln Asp Ser Gly Phe Ile Val Ala Ile Asn Lys
Asp Glu Asn Ala 290 295 300 Pro Met Met Gln Val Ala Asp Leu Ala Ile
Val Gly Asp Leu Tyr Lys 305 310 315 320 Val Val Pro Glu Phe Val Glu
Gln Val Lys Ala Leu Asn Leu 325 330 103259PRTClostridium kluyveri
103Met Lys Ile Val Val Cys Leu Lys Gln Val Pro Asp Thr Thr Glu Val
1 5 10 15 Lys Ile Asp Pro Lys Thr Gly Thr Leu Ile Arg Glu Gly Val
Pro Ser 20 25 30 Ile Ile Asn Pro Asp Asp Lys Asn Ala Leu Glu Glu
Ser Ile Ala Leu 35 40 45 Lys Glu Lys Val Gly Gly Thr Val Thr Val
Val Ser Met Gly Pro Pro 50 55 60 Gln Ala Val Asp Ala Leu Arg Glu
Ala Leu Ala Met Gly Ala Asp Glu 65 70 75 80 Ala Ile Leu Val Ser Asp
Arg Ala Phe Ala Gly Ala Asp Thr Gln Ala 85 90 95 Thr Ser Tyr Ala
Leu Ala Gly Ala Leu Lys Asn Leu Glu Tyr Asp Leu 100 105 110 Ile Phe
Ala Gly Arg Gln Ala Ile Asp Gly Asp Thr Ala Gln Val Gly 115 120 125
Pro Gln Ile Ala Glu Lys Leu Gly Ile Pro Gln Ile Thr Tyr Val Glu 130
135 140 Lys Val Asp Val Asp Gly Asp Thr Leu Thr Val Gln Arg Ala Trp
Glu 145 150 155 160 Asp Gly Tyr Glu Val Ala Lys Ile Lys Thr Pro Cys
Met Leu Thr Ala 165 170 175 Ile Lys Glu Leu Asn Gln Pro Arg Tyr Met
Asn Met Lys Asn Ile Phe 180 185 190 Glu Val Phe Lys Lys Glu Val Lys
Ile Trp Ser Ala Asp Asp Leu Asp 195 200 205 Val Asp Lys Asn Lys Leu
Gly Leu Asn Gly Ser Cys Thr Lys Val Lys 210 215 220 Arg Ser His Thr
Lys Glu Ala Lys Gly Ala Gly Glu Ile Val Asn Lys 225 230 235 240 Pro
Ile Lys Glu Ala Val Ala Tyr Ser Ile Ser Lys Leu Arg Glu Lys 245 250
255 His Val Ile 1041196DNAArtificialMegasphaera elsdenii
104ggtaccggat ccctaacagg aggaattaac catggacttc aacctgactg
atatccagca 60ggacttcctg aaactggcac acgacttcgg tgaaaaaaaa ctggcaccaa
ccgtaactga 120acgtgaccac aaaggtatct acgacaaaga gctgatcgac
gaactgctgt ctctgggtat 180cactggcgct tacttcgaag agaaatacgg
tggttctggt gacgacggtg gtgacgttct 240gtcttacatc ctggctgttg
aagaactggc gaaatacgac gctggcgttg ctatcactct 300gtctgcaacc
gtttctctgt gcgcaaaccc gatctggcag ttcggtactg aagcgcagaa
360agagaagttc ctggttccgc tggttgaagg tactaaactg ggtgcattcg
gtctgactga 420accgaacgct ggtactgacg cttctggtca gcagactatc
gctaccaaaa acgacgacgg 480tacttacact ctgaacggtt ctaaaatctt
catcactaac ggtggtgcag ctgacatcta 540catcgttttc gcaatgactg
acaagtctaa aggtaaccac ggtatcactg cattcatcct 600ggaagatggt
actccgggct tcacttacgg taagaaagaa gataaaatgg gtatccacac
660ttctcagact atggaactgg tattccagga cgttaaagtt ccggcagaaa
acatgctggg 720tgaagaaggt aaaggcttca aaatcgcgat gatgactctg
gacggtggtc gtatcggtgt 780tgctgctcag gcgctgggta tcgctgaagc
ggcactggct gacgcggtag aatactccaa 840gcagcgtgta cagttcggta
agccgctgtg caaattccag tctatctcct tcaaactggc 900tgatatgaag
atgcagatcg aagcagctcg caacctggtt tacaaagcgg catgtaagaa
960gcaggaaggt aagccgttca ccgttgatgc tgctatcgct aaacgcgttg
cttctgacgt 1020tgcgatgcgc gtaactactg aagctgttca gattttcggt
ggttacggtt actctgaaga 1080atacccggtt gcgcgtcaca tgcgtgacgc
taaaatcact cagatttacg aaggtactaa 1140cgaagttcag ctgatggtta
ctggcggtgc gctgctgcgt gagctctaat aagctt 1196105385PRTMegasphaera
elsdenii 105Met Asp Phe Asn Leu Thr Asp Ile Gln Gln Asp Phe Leu Lys
Leu Ala 1 5 10 15 His Asp Phe Gly Glu Lys Lys Leu Ala Pro Thr Val
Thr Glu Arg Asp 20 25 30 His Lys Gly Ile Tyr Asp Lys Glu Leu Ile
Asp Glu Leu Leu Ser Leu 35 40 45 Gly Ile Thr Gly Ala Tyr Phe Glu
Glu Lys Tyr Gly Gly Ser Gly Asp 50 55 60 Asp Gly Gly Asp Val Leu
Ser Tyr Ile Leu Ala Val Glu Glu Leu Ala 65 70 75 80 Lys Tyr Asp Ala
Gly Val Ala Ile Thr Leu Ser Ala Thr Val Ser Leu 85 90 95 Cys Ala
Asn Pro Ile Trp Gln Phe Gly Thr Glu Ala Gln Lys Glu Lys 100 105 110
Phe Leu Val Pro Leu Val Glu Gly Thr Lys Leu Gly Ala Phe Gly Leu 115
120 125 Thr Glu Pro Asn Ala Gly Thr Asp Ala Ser Gly Gln Gln Thr Ile
Ala 130 135 140 Thr Lys Asn Asp Asp Gly Thr Tyr Thr Leu Asn Gly Ser
Lys Ile Phe 145 150 155
160 Ile Thr Asn Gly Gly Ala Ala Asp Ile Tyr Ile Val Phe Ala Met Thr
165 170 175 Asp Lys Ser Lys Gly Asn His Gly Ile Thr Ala Phe Ile Leu
Glu Asp 180 185 190 Gly Thr Pro Gly Phe Thr Tyr Gly Lys Lys Glu Asp
Lys Met Gly Ile 195 200 205 His Thr Ser Gln Thr Met Glu Leu Val Phe
Gln Asp Val Lys Val Pro 210 215 220 Ala Glu Asn Met Leu Gly Glu Glu
Gly Lys Gly Phe Lys Ile Ala Met 225 230 235 240 Met Thr Leu Asp Gly
Gly Arg Ile Gly Val Ala Ala Gln Ala Leu Gly 245 250 255 Ile Ala Glu
Ala Ala Leu Ala Asp Ala Val Glu Tyr Ser Lys Gln Arg 260 265 270 Val
Gln Phe Gly Lys Pro Leu Cys Lys Phe Gln Ser Ile Ser Phe Lys 275 280
285 Leu Ala Asp Met Lys Met Gln Ile Glu Ala Ala Arg Asn Leu Val Tyr
290 295 300 Lys Ala Ala Cys Lys Lys Gln Glu Gly Lys Pro Phe Thr Val
Asp Ala 305 310 315 320 Ala Ile Ala Lys Arg Val Ala Ser Asp Val Ala
Met Arg Val Thr Thr 325 330 335 Glu Ala Val Gln Ile Phe Gly Gly Tyr
Gly Tyr Ser Glu Glu Tyr Pro 340 345 350 Val Ala Arg His Met Arg Asp
Ala Lys Ile Thr Gln Ile Tyr Glu Gly 355 360 365 Thr Asn Glu Val Gln
Leu Met Val Thr Gly Gly Ala Leu Leu Arg Glu 370 375 380 Thr 385
1061421DNAArtificialAcinetobacter sp. 106ggtacctttt ttgggctaac
aggaggaatt aaccatgatc aacaagatca tcaacgatat 60cgaaccgatt ctgaaatcta
tcccagacgg ttctaccatc atgacttctg gcttcggtac 120taccggtcag
ccggaagcgc tgctggaagc gctgatcgac ttcgcaccga aagagctgac
180tatcatcaac aacaacgctt cttccggtcc gaacggtctg actcagctgt
tcactgctgg 240tctggttaag aaactgatct gctcctaccc gaaatctatc
tcttccaccg ttttcccgga 300cctgtaccgc gctggtaaga tcgaactgga
actggttccg cagggtaacc tggcttgccg 360tatccaggca gctggcgcgg
gtctgggtgc agtattcact ccgactggtt acggtactaa 420gatcgctgaa
ggtaaagaaa ctcgtatcat caacggtaaa aactacgttc tggaataccc
480gctggaagct gactacgcat tcatctacgc tgacaaagct gaccgctggg
gtaacctgac 540ttaccgtaaa gcggcacgta acttcggtcc gatcatggcg
aaagcagcta aaaccactat 600tgctcaggtt aaccagactg ttgaactggg
cgatctggac ccggaatgca tcatcactcc 660gggtatcttc gtacagcacg
ttgttcgtct gggtgacatc aaataatttt ttgggctaac 720aggaggaatt
aaccatgact attcagaagc gttctcgcga agatatcgct atcatgatcg
780ctaaagacat cccggacggt tcttacgtta acctgggtat cggtctgccg
actcacgttg 840ctaaatatct gccgaaagac aaagaaatct tcctgcactc
tgaaaacggt gttctggcat 900tcggtccgcc gccagcagaa ggtgaagaag
atcaggacct ggttaacgct ggtaaagagc 960tggtaactct gctgtctggt
ggttgcttca tgcaccacgg tgactccttc gacatcatgc 1020gtggtggtca
cctggatatc tgcgttatcg gtgcattcca ggttgcgctg aacggtgacc
1080tggctaactg gcacaccggt aaagacgacg acgttccggc agtaggtggt
gcaatggacc 1140tggctgttgg tgcgaagcgt atcttcgttt acatggaaca
caccaccaag aaaggtgaac 1200cgaaaatcgt taagcacctg acttacccga
tcaccggtga acagtgcgta gaccgtatct 1260acactgacct gtgcaccatc
gaactgaaag acggtcaggc ttacgttatc gaaatggttg 1320acggtctgga
tttcgacact ctgcaggcgc tgactgaatg cccgctgatc gaccactgca
1380cctactcttc tctgattcag ctcagataag gatccgagct c
1421107223PRTAcinetobacter sp. 107Met Ile Asn Lys Ile Ile Asn Asp
Ile Glu Pro Ile Leu Lys Ser Ile 1 5 10 15 Pro Asp Gly Ser Thr Ile
Met Thr Ser Gly Phe Gly Thr Thr Gly Gln 20 25 30 Pro Glu Ala Leu
Leu Glu Ala Leu Ile Asp Phe Ala Pro Lys Glu Leu 35 40 45 Thr Ile
Ile Asn Asn Asn Ala Ser Ser Gly Pro Asn Gly Leu Thr Gln 50 55 60
Leu Phe Thr Ala Gly Leu Val Lys Lys Leu Ile Cys Ser Tyr Pro Lys 65
70 75 80 Ser Ile Ser Ser Thr Val Phe Pro Asp Leu Tyr Arg Ala Gly
Lys Ile 85 90 95 Glu Leu Glu Leu Val Pro Gln Gly Asn Leu Ala Cys
Arg Ile Gln Ala 100 105 110 Ala Gly Ala Gly Leu Gly Ala Val Phe Thr
Pro Thr Gly Tyr Gly Thr 115 120 125 Lys Ile Ala Glu Gly Lys Glu Thr
Arg Ile Ile Asn Gly Lys Asn Tyr 130 135 140 Val Leu Glu Tyr Pro Leu
Glu Ala Asp Tyr Ala Phe Ile Tyr Ala Asp 145 150 155 160 Lys Ala Asp
Arg Trp Gly Asn Leu Thr Tyr Arg Lys Ala Ala Arg Asn 165 170 175 Phe
Gly Pro Ile Met Ala Lys Ala Ala Lys Thr Thr Ile Ala Gln Val 180 185
190 Asn Gln Thr Val Glu Leu Gly Asp Leu Asp Pro Glu Cys Ile Ile Thr
195 200 205 Pro Gly Ile Phe Val Gln His Val Val Arg Leu Gly Asp Ile
Lys 210 215 220 1081190DNAArtificialDeinococcus radiodurans
108ggtaccggat ccctaacagg aggaattaac catggacttc aatctgccgg
acgatctgcg 60tgaagttcag gcaactatcc gtgacttcat gctgactcgc gttgaagatc
gcgctcagga 120aatcgaacac accaactccg taccgccgga actgatcaaa
gaagcggcag acctgggtct 180gttcggtctg tctatcccgg aagaatacgg
tggtgttggt ctgtcctctc tgggtcgttg 240cgcagtttac gaagcgatgg
gtcagggtca catgggcttc ggtggtatga tctccgcaca 300cgcttctatc
ggtacttctg gtctggttaa actgggtaac gaagagcaga agcagcgttt
360cctgccgcgt atggcggcag gcgaatgcat cgctggcttc gctatcactg
aaccaagctc 420cggttctgac gctggtaaca tccgtactaa agctgttaag
aaaggcgacg tttacgttct 480gaacggtact aagcactaca tctccaacgc
tccgatcgct ggtctgctga ccgttatcgc 540tatcactgac ccggcacagg
gttcccgtgg tatgtccgca ttcctggttg aaccgcagtc 600tactccgggc
gtatctatcg gtaaaatcga cgaaaaaatg ggtcagaaag gtgcgctgtc
660tgcagaagtt atcttcgaag atgctgaaat cccggctgct aaccttctcg
gtccggaaaa 720ccgcggttac cgtgaagcgc tgggtattct gactaacggt
cgcgttggta tcgctgcacg 780ttctactggc gcgatgcagc gtctgctgga
cctgtctgtt gcacacgctc agactcgcga 840gcagttcggt aagccgatcg
ctgagttcca ggcggtacag ttcatgctgg cagaaatgga 900agttgcgatt
cagacttctc gcgtactgtg gcagaaagtt gcatggatgg ttgaccaggg
960tcaggacgtt aagcgtatgg cgtctgttgc taaataccac gcaactgaaa
tgctgtctca 1020ggttgctgac aaagcggtac aggttgctgg cggtatgggt
tacgttaaag acgctccgtt 1080cgaacgtttc taccgcgacc agcgtctgct
gcgtatctac gaaggtactt ctgaaatcca 1140gaaagttatc atcgctgctg
aactgctgcg tcgcgagctc taataagctt 1190109383PRTDeinococcus
radiodurans 109Met Asp Phe Asn Leu Pro Asp Asp Leu Arg Glu Val Gln
Ala Thr Ile 1 5 10 15 Arg Asp Phe Met Leu Thr Arg Val Glu Asp Arg
Ala Gln Glu Ile Glu 20 25 30 His Thr Asn Ser Val Pro Pro Glu Leu
Ile Lys Glu Ala Ala Asp Leu 35 40 45 Gly Leu Phe Gly Leu Ser Ile
Pro Glu Glu Tyr Gly Gly Val Gly Leu 50 55 60 Ser Ser Leu Gly Arg
Cys Ala Val Tyr Glu Ala Met Gly Gln Gly His 65 70 75 80 Met Gly Phe
Gly Gly Met Ile Ser Ala His Ala Ser Ile Gly Thr Ser 85 90 95 Gly
Leu Val Lys Leu Gly Asn Glu Glu Gln Lys Gln Arg Phe Leu Pro 100 105
110 Arg Met Ala Ala Gly Glu Cys Ile Ala Gly Phe Ala Ile Thr Glu Pro
115 120 125 Ser Ser Gly Ser Asp Ala Gly Asn Ile Arg Thr Lys Ala Val
Lys Lys 130 135 140 Gly Asp Val Tyr Val Leu Asn Gly Thr Lys His Tyr
Ile Ser Asn Ala 145 150 155 160 Pro Ile Ala Gly Leu Leu Thr Val Ile
Ala Ile Thr Asp Pro Ala Gln 165 170 175 Gly Ser Arg Gly Met Ser Ala
Phe Leu Val Glu Pro Gln Ser Thr Pro 180 185 190 Gly Val Ser Ile Gly
Lys Ile Asp Glu Lys Met Gly Gln Lys Gly Ala 195 200 205 Leu Ser Ala
Glu Val Ile Phe Glu Asp Ala Glu Ile Pro Ala Ala Asn 210 215 220 Leu
Leu Gly Pro Glu Asn Arg Gly Tyr Arg Glu Ala Leu Gly Ile Leu 225 230
235 240 Thr Asn Gly Arg Val Gly Ile Ala Ala Arg Ser Thr Gly Ala Met
Gln 245 250 255 Arg Leu Leu Asp Leu Ser Val Ala His Ala Gln Thr Arg
Glu Gln Phe 260 265 270 Gly Lys Pro Ile Ala Glu Phe Gln Ala Val Gln
Phe Met Leu Ala Glu 275 280 285 Met Glu Val Ala Ile Gln Thr Ser Arg
Val Leu Trp Gln Lys Val Ala 290 295 300 Trp Met Val Asp Gln Gly Gln
Asp Val Lys Arg Met Ala Ser Val Ala 305 310 315 320 Lys Tyr His Ala
Thr Glu Met Leu Ser Gln Val Ala Asp Lys Ala Val 325 330 335 Gln Val
Ala Gly Gly Met Gly Tyr Val Lys Asp Ala Pro Phe Glu Arg 340 345 350
Phe Tyr Arg Asp Gln Arg Leu Leu Arg Ile Tyr Glu Gly Thr Ser Glu 355
360 365 Ile Gln Lys Val Ile Ile Ala Ala Glu Leu Leu Arg Arg Glu Thr
370 375 380 1101202DNAArtificialArabidopsis thaliana 110ggtaccggat
ccctaacagg aggaattaac catggcctct tctctgctgt tcgacgacac 60tcagctgcag
ttcaaagaat ccgtttccaa gttcgctcag gacaacatcg ctccgcacgc
120tgaacgtatc gacaaaacta actccttccc gaaagacgtt aacctgtgga
aactgatggg 180cgagttcaat ctgcacggta tcactgcgcc agaagaatac
ggtggtctgg gtctgggtta 240cctgtaccac tgcatcgcga tggaagaaat
ctctcgcgct tctggttctg ttgctctgtc 300ttacggcgca cactctaacc
tgtgcatcaa ccagctggta cgtaacggta ctgctgcaca 360gaaagagaag
tatctgccga aactgatctc cggtgaacac gttggtgcac tggcgatgtc
420tgaaccgaac gctggttctg acgttgttgg tatgaagtgc aaagcagaaa
aagttgacgg 480tggttacatt ctgaacggta acaagatgtg gtgcaccaac
ggtccgtctg ctgaaactct 540ggttgtttac gctaaaactg acaccaaagc
gggttctaaa ggtatcactg cattcatcat 600cgaaaaaggt atgaccggtt
tctccactgc tcagaagctg gacaagctgg gtatgcgcgg 660ttctgacact
tgcgaactgg tattcgaaaa ctgcttcgta ccggaagaaa acatcctgga
720taaagaaggt aaaggcgttt acgttctgat gtccggtctg gatctggaac
gtctggtact 780ggcagctggt ccgctgggta tcatgcaggc ttgcctggat
aacgtactgc cgtacatccg 840tcagcgtgaa cagttcggtc gtccggttgg
cgagttccag ttcatccagg gtaaagttgc 900tgacatgtac actgcgctgc
agtcctcccg ttcttacgtt tactccgttg ctcgcgactg 960cgacaacggt
aaagttgatc cgaaagactg cgcaggcact atcctgtgcg cagctgaacg
1020tgcaactcag gttgcgctgc aggcgattca gtgcctgggt ggtaacggtt
acatcaacga 1080atacgcaact ggtcgtctgc tgcgcgacgc gaagctgtac
gaaatcggtg ctggtacttc 1140tgaaatccgc cgtatcgtta tcggtcgtga
actgttcaaa gaagaagagc tctaataagc 1200tt 1202111387PRTArabidopsis
thaliana 111Met Ala Ser Ser Leu Leu Phe Asp Asp Thr Gln Leu Gln Phe
Lys Glu 1 5 10 15 Ser Val Ser Lys Phe Ala Gln Asp Asn Ile Ala Pro
His Ala Glu Arg 20 25 30 Ile Asp Lys Thr Asn Ser Phe Pro Lys Asp
Val Asn Leu Trp Lys Leu 35 40 45 Met Gly Glu Phe Asn Leu His Gly
Ile Thr Ala Pro Glu Glu Tyr Gly 50 55 60 Gly Leu Gly Leu Gly Tyr
Leu Tyr His Cys Ile Ala Met Glu Glu Ile 65 70 75 80 Ser Arg Ala Ser
Gly Ser Val Ala Leu Ser Tyr Gly Ala His Ser Asn 85 90 95 Leu Cys
Ile Asn Gln Leu Val Arg Asn Gly Thr Ala Ala Gln Lys Glu 100 105 110
Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu His Val Gly Ala Leu Ala 115
120 125 Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Gly Met Lys Cys
Lys 130 135 140 Ala Glu Lys Val Asp Gly Gly Tyr Ile Leu Asn Gly Asn
Lys Met Trp 145 150 155 160 Cys Thr Asn Gly Pro Ser Ala Glu Thr Leu
Val Val Tyr Ala Lys Thr 165 170 175 Asp Thr Lys Ala Gly Ser Lys Gly
Ile Thr Ala Phe Ile Ile Glu Lys 180 185 190 Gly Met Thr Gly Phe Ser
Thr Ala Gln Lys Leu Asp Lys Leu Gly Met 195 200 205 Arg Gly Ser Asp
Thr Cys Glu Leu Val Phe Glu Asn Cys Phe Val Pro 210 215 220 Glu Glu
Asn Ile Leu Asp Lys Glu Gly Lys Gly Val Tyr Val Leu Met 225 230 235
240 Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala Ala Gly Pro Leu Gly
245 250 255 Ile Met Gln Ala Cys Leu Asp Asn Val Leu Pro Tyr Ile Arg
Gln Arg 260 265 270 Glu Gln Phe Gly Arg Pro Val Gly Glu Phe Gln Phe
Ile Gln Gly Lys 275 280 285 Val Ala Asp Met Tyr Thr Ala Leu Gln Ser
Ser Arg Ser Tyr Val Tyr 290 295 300 Ser Val Ala Arg Asp Cys Asp Asn
Gly Lys Val Asp Pro Lys Asp Cys 305 310 315 320 Ala Gly Thr Ile Leu
Cys Ala Ala Glu Arg Ala Thr Gln Val Ala Leu 325 330 335 Gln Ala Ile
Gln Cys Leu Gly Gly Asn Gly Tyr Ile Asn Glu Tyr Ala 340 345 350 Thr
Gly Arg Leu Leu Arg Asp Ala Lys Leu Tyr Glu Ile Gly Ala Gly 355 360
365 Thr Ser Glu Ile Arg Arg Ile Val Ile Gly Arg Glu Leu Phe Lys Glu
370 375 380 Glu Glu Thr 385 1121232DNAArtificialHomo sapiens
112ggtaccggat ccctaacagg aggaattaac catgggtccg gaatttgact
ggcaggaccc 60gctggtactg gaagagcagc tgaccactga cgaaatcctg atccgtgaca
ccttccgtac 120ttactgccag gaacgtctga tgccgcgcat tctgctggct
aaccgtaacg aagttttcca 180ccgtgaaatc atctctgaaa tgggtgaact
gggtgttctg ggtccgacta tcaaaggtta 240cggttgcgca ggcgtttctt
ccgttgctta cggtctgctg gcgcgtgaac tggaacgcgt 300tgactccggt
taccgttctg caatgtccgt tcagtcctct ctggtaatgc acccaatcta
360cgcttacggt tctgaagagc agcgtcagaa atatctgccg cagctggcga
aaggtgaact 420gctgggttgc ttcggtctga ctgaaccgaa ctccggttct
gacccgtcct ctatggaaac 480tcgcgcacac tacaactctt ctaacaagtc
ttacactctg aacggcacca aaacctggat 540cactaactct ccgatggctg
acctgttcgt tgtatgggct cgctgcgaag atggttgcat 600ccgcggtttc
ctgctggaaa aaggtatgcg tggtctgtct gcaccgcgta tccagggtaa
660gttctctctg cgcgcttctg caactggtat gatcatcatg gacggtgttg
aagttccgga 720agaaaacgtt ctgccgggtg catcttctct gggtggtccg
ttcggttgcc tgaacaacgc 780gcgttacggt atcgcatggg gcgtactggg
tgcttctgag ttctgcctgc acactgcacg 840tcagtacgca ctggatcgca
tgcagttcgg tgttccgctg gcgcgtaacc agctgattca 900gaagaaactg
gctgacatgc tgactgaaat cactctgggt ctgcacgctt gcctgcagct
960gggtcgtctg aaagaccagg acaaagctgc accggaaatg gtttctctgc
tgaagcgtaa 1020caactgcggt aaagcgctgg atatcgctcg ccaggctcgc
gacatgctgg gtggtaacgg 1080tatctctgac gaataccacg ttatccgtca
cgcgatgaac ctggaagctg ttaacaccta 1140cgaaggtact cacgacatcc
acgcgctgat cctgggtcgt gctatcaccg gtatccaggc 1200tttcactgct
tctaaagagc tctaataagc tt 1232113397PRTHomo sapiens 113Met Gly Pro
Glu Phe Asp Trp Gln Asp Pro Leu Val Leu Glu Glu Gln 1 5 10 15 Leu
Thr Thr Asp Glu Ile Leu Ile Arg Asp Thr Phe Arg Thr Tyr Cys 20 25
30 Gln Glu Arg Leu Met Pro Arg Ile Leu Leu Ala Asn Arg Asn Glu Val
35 40 45 Phe His Arg Glu Ile Ile Ser Glu Met Gly Glu Leu Gly Val
Leu Gly 50 55 60 Pro Thr Ile Lys Gly Tyr Gly Cys Ala Gly Val Ser
Ser Val Ala Tyr 65 70 75 80 Gly Leu Leu Ala Arg Glu Leu Glu Arg Val
Asp Ser Gly Tyr Arg Ser 85 90 95 Ala Met Ser Val Gln Ser Ser Leu
Val Met His Pro Ile Tyr Ala Tyr 100 105 110 Gly Ser Glu Glu Gln Arg
Gln Lys Tyr Leu Pro Gln Leu Ala Lys Gly 115 120 125 Glu Leu Leu Gly
Cys Phe Gly Leu Thr Glu Pro Asn Ser Gly Ser Asp 130 135 140 Pro Ser
Ser Met Glu Thr Arg Ala His Tyr Asn Ser Ser Asn Lys Ser 145 150 155
160 Tyr Thr Leu Asn Gly Thr Lys Thr Trp Ile Thr Asn Ser Pro Met Ala
165 170 175 Asp Leu Phe Val Val Trp Ala Arg Cys Glu Asp Gly Cys Ile
Arg Gly 180 185 190 Phe Leu Leu Glu Lys Gly Met Arg Gly Leu Ser Ala
Pro Arg Ile Gln 195 200 205 Gly Lys Phe Ser Leu Arg Ala Ser Ala Thr
Gly Met Ile Ile Met Asp 210 215 220 Gly Val Glu Val Pro Glu Glu Asn
Val Leu Pro Gly Ala Ser Ser Leu 225 230 235 240 Gly Gly Pro Phe Gly
Cys Leu Asn Asn Ala Arg Tyr Gly Ile Ala Trp 245 250
255 Gly Val Leu Gly Ala Ser Glu Phe Cys Leu His Thr Ala Arg Gln Tyr
260 265 270 Ala Leu Asp Arg Met Gln Phe Gly Val Pro Leu Ala Arg Asn
Gln Leu 275 280 285 Ile Gln Lys Lys Leu Ala Asp Met Leu Thr Glu Ile
Thr Leu Gly Leu 290 295 300 His Ala Cys Leu Gln Leu Gly Arg Leu Lys
Asp Gln Asp Lys Ala Ala 305 310 315 320 Pro Glu Met Val Ser Leu Leu
Lys Arg Asn Asn Cys Gly Lys Ala Leu 325 330 335 Asp Ile Ala Arg Gln
Ala Arg Asp Met Leu Gly Gly Asn Gly Ile Ser 340 345 350 Asp Glu Tyr
His Val Ile Arg His Ala Met Asn Leu Glu Ala Val Asn 355 360 365 Thr
Tyr Glu Gly Thr His Asp Ile His Ala Leu Ile Leu Gly Arg Ala 370 375
380 Ile Thr Gly Ile Gln Ala Phe Thr Ala Ser Lys Glu Thr 385 390 395
1141784DNAArtificialHomo sapiens 114ggtaccggat ccctaacagg
aggaattaat catgaccact ctggttatcg ctgaacacgc 60taacgactct ctggcaccaa
tcactctgaa caccatcact gcggcaactc gtctgggtgg 120tgaagtttcc
tgcctggttg ctggcaccaa gtgcgacaaa gttgctcagg acctgtgcaa
180agtagcgggt atcgcgaaag ttctggtagc gcagcacgac gtttacaaag
gtctgctgcc 240ggaagagctg actccgctga tcctggcaac tcagaagcag
ttcaactaca ctcacatctg 300tgcgggtgct tctgcattcg gtaaaaatct
gctgccgcgc gttgctgcga aactggaagt 360tgcaccgatt tctgacatca
tcgctatcaa gtctccggat accttcgtac gtactatcta 420cgctggtaac
gcactgtgca ccgttaagtg cgacgaaaaa gttaaagtat tctctgtacg
480tggtacttct ttcgacgctg cagcaacttc tggtggttct gcatcttctg
aaaaagcatc 540ttccacttct ccggttgaaa tctctgagtg gctggatcag
aaactgacca agtctgaccg 600tccggaactg actggcgcga aagttgttgt
ttctggtggt cgtggtctga aatctggtga 660aaacttcaaa ctgctgtacg
acctggctga ccagctgcac gctgctgttg gtgcttctcg 720cgctgctgtt
gatgctggct tcgtaccgaa cgacatgcaa gttggtcaga ctggtaaaat
780cgttgcaccg gaactgtaca tcgctgttgg tatctccggt gcgattcagc
acctggcggg 840tatgaaagac tccaaaacta tcgttgctat caacaaagac
ccggaagcac cgatcttcca 900ggttgctgac tacggtatcg ttgctgacct
gttcaaagtt gttccggaaa tgactgaaat 960cctgaagaag aagtaataac
tagtctaaca ggaggaatta accatggctg aactgcgcgt 1020actggttgct
gttaagcgcg ttatcgacta cgcagttaaa atccgcgtta agccggaccg
1080tactggcgtt gttactgacg gtgttaaaca ctctatgaac ccgttctgcg
aaatcgctgt 1140tgaagaagcg gtacgtctga aagagaagaa actggttaaa
gaagttatcg ctgtttcctg 1200cggtccggca cagtgccagg aaaccattcg
tactgcactg gcgatgggcg cagaccgcgg 1260tatccacgtt gaagttccgc
cagctgaagc agaacgtctg ggtccgctcc aggttgctcg 1320cgtactggcg
aaactggctg aaaaagaaaa agttgacctg gtactgctgg gtaagcaggc
1380tatcgacgac gactgcaacc agactggtca gatgactgct ggcttcctgg
actggccgca 1440gggtactttc gcttctcagg taactctgga aggtgacaaa
ctgaaagttg aacgtgaaat 1500cgacggtggt ctggaaactc tgcgtctgaa
actgccggca gttgttactg ctgatctgcg 1560tctgaacgaa ccgcgttacg
caactctgcc gaacattatg aaagcgaaga agaagaaaat 1620cgaagttatc
aagccgggcg acctgggtgt tgacctgact tctaaactgt ctgttatctc
1680cgttgaagat ccgccgcagc gtactgctgg cgttaaagtt gaaaccactg
aggatctggt 1740agcgaaactg aaagaaatcg gtcgtatcga gctctaataa gctt
1784115314PRTHomo sapiens 115Met Thr Thr Leu Val Ile Ala Glu His
Ala Asn Asp Ser Leu Ala Pro 1 5 10 15 Ile Thr Leu Asn Thr Ile Thr
Ala Ala Thr Arg Leu Gly Gly Glu Val 20 25 30 Ser Cys Leu Val Ala
Gly Thr Lys Cys Asp Lys Val Ala Gln Asp Leu 35 40 45 Cys Lys Val
Ala Gly Ile Ala Lys Val Leu Val Ala Gln His Asp Val 50 55 60 Tyr
Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile Leu Ala Thr 65 70
75 80 Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala Ser Ala
Phe 85 90 95 Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu
Val Ala Pro 100 105 110 Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp
Thr Phe Val Arg Thr 115 120 125 Ile Tyr Ala Gly Asn Ala Leu Cys Thr
Val Lys Cys Asp Glu Lys Val 130 135 140 Lys Val Phe Ser Val Arg Gly
Thr Ser Phe Asp Ala Ala Ala Thr Ser 145 150 155 160 Gly Gly Ser Ala
Ser Ser Glu Lys Ala Ser Ser Thr Ser Pro Val Glu 165 170 175 Ile Ser
Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp Arg Pro Glu 180 185 190
Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly Leu Lys Ser 195
200 205 Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln Leu His
Ala 210 215 220 Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe
Val Pro Asn 225 230 235 240 Asp Met Gln Val Gly Gln Thr Gly Lys Ile
Val Ala Pro Glu Leu Tyr 245 250 255 Ile Ala Val Gly Ile Ser Gly Ala
Ile Gln His Leu Ala Gly Met Lys 260 265 270 Asp Ser Lys Thr Ile Val
Ala Ile Asn Lys Asp Pro Glu Ala Pro Ile 275 280 285 Phe Gln Val Ala
Asp Tyr Gly Ile Val Ala Asp Leu Phe Lys Val Val 290 295 300 Pro Glu
Met Thr Glu Ile Leu Lys Lys Lys 305 310 116255PRTHomo sapiens
116Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
1 5 10 15 Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val
Thr Asp 20 25 30 Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile
Ala Val Glu Glu 35 40 45 Ala Val Arg Leu Lys Glu Lys Lys Leu Val
Lys Glu Val Ile Ala Val 50 55 60 Ser Cys Gly Pro Ala Gln Cys Gln
Glu Thr Ile Arg Thr Ala Leu Ala 65 70 75 80 Met Gly Ala Asp Arg Gly
Ile His Val Glu Val Pro Pro Ala Glu Ala 85 90 95 Glu Arg Leu Gly
Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala 100 105 110 Glu Lys
Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp 115 120 125
Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp 130
135 140 Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu Gly Asp Lys
Leu 145 150 155 160 Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr
Leu Arg Leu Lys 165 170 175 Leu Pro Ala Val Val Thr Ala Asp Leu Arg
Leu Asn Glu Pro Arg Tyr 180 185 190 Ala Thr Leu Pro Asn Ile Met Lys
Ala Lys Lys Lys Lys Ile Glu Val 195 200 205 Ile Lys Pro Gly Asp Leu
Gly Val Asp Leu Thr Ser Lys Leu Ser Val 210 215 220 Ile Ser Val Glu
Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu 225 230 235 240 Thr
Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile 245 250 255
117316PRTHomo sapiens 117Met Ser Ser Pro Gln Ala Pro Glu Asp Gly
Gln Gly Cys Gly Asp Arg 1 5 10 15 Gly Asp Pro Pro Gly Asp Leu Arg
Ser Val Leu Val Thr Thr Val Leu 20 25 30 Asn Leu Glu Pro Leu Asp
Glu Asp Leu Phe Arg Gly Arg His Tyr Trp 35 40 45 Val Pro Ala Lys
Arg Leu Phe Gly Gly Gln Ile Val Gly Gln Ala Leu 50 55 60 Val Ala
Ala Ala Lys Ser Val Ser Glu Asp Val His Val His Ser Leu 65 70 75 80
His Cys Tyr Phe Val Arg Ala Gly Asp Pro Lys Leu Pro Val Leu Tyr 85
90 95 Gln Val Glu Arg Thr Arg Thr Gly Ser Ser Phe Ser Val Arg Ser
Val 100 105 110 Lys Ala Val Gln His Gly Lys Pro Ile Phe Ile Cys Gln
Ala Ser Phe 115 120 125 Gln Gln Ala Gln Pro Ser Pro Met Gln His Gln
Phe Ser Met Pro Thr 130 135 140 Val Pro Pro Pro Glu Glu Leu Leu Asp
Cys Glu Thr Leu Ile Asp Gln 145 150 155 160 Tyr Leu Arg Asp Pro Asn
Leu Gln Lys Arg Tyr Pro Leu Ala Leu Asn 165 170 175 Arg Ile Ala Ala
Gln Glu Val Pro Ile Glu Ile Lys Pro Val Asn Pro 180 185 190 Ser Pro
Leu Ser Gln Leu Gln Arg Met Glu Pro Lys Gln Met Phe Trp 195 200 205
Val Arg Ala Arg Gly Tyr Ile Gly Glu Gly Asp Met Lys Met His Cys 210
215 220 Cys Val Ala Ala Tyr Ile Ser Asp Tyr Ala Phe Leu Gly Thr Ala
Leu 225 230 235 240 Leu Pro His Gln Trp Gln His Lys Val His Phe Met
Val Ser Leu Asp 245 250 255 His Ser Met Trp Phe His Ala Pro Phe Arg
Ala Asp His Trp Met Leu 260 265 270 Tyr Glu Cys Glu Ser Pro Trp Ala
Gly Gly Ser Arg Gly Leu Val His 275 280 285 Gly Arg Leu Trp Arg Gln
Asp Gly Val Leu Ala Val Thr Cys Ala Gln 290 295 300 Glu Gly Val Ile
Arg Val Lys Pro Gln Val Ser Glu 305 310 315
118931DNAArtificialHyphomonas neptunium 118ggtacctttt ttgggctaac
aggaggaatt aaccatggcg aaagacccgg ttggcgatct 60gctgactctg ctggatctgg
aacgtctgga actggatctg ttccgcggtc agtctccgga 120cgaagaagaa
tctcagcgcg tattcggtgg tcaggttatc gctcagtctc tggttgctgc
180ttaccgtact gtaccggacg accgtctgtg ccactctctg cactgctact
tcatccgtcc 240gggcgacccg tctgtaccaa tcatctacca ggttgaccac
tctcgcgacg gtggttcttt 300caccactcgt cgcgttgttg ctatccagca
cggtaagcag attttcaacc tggcagcttc 360tttccacgtt gttgaagatt
cctggcacca ccagcacgaa atgccggaag ttgacccgcc 420agaatccgta
ggtgaccgta tcgagtggcg tcgtaaattc gctgaacagg ttccggaacg
480tcaccgcggt cacttcctgc gcgaccgtcc ggttgaaatg cgtgaaatcg
acccgctgga 540cccgctgaaa ccggcaaaag cgtctgacca gcagaacctg
tggttccgcg ttgctcgtcc 600gatcgacgaa gcgccgtggc tgcaccactg
cctgatggct tacgcttctg acatggcgct 660gctgggtact ggtaaccgtc
cgcacggtat ctcctggatg accggtgaac tgatgtccgc 720atctctggat
cacgcgatgt ggttccacgc accgactaaa ttcgacgagt ggcacctgta
780ctctatggac tctccgtacg caggcggtgc acgttctttc aaccgcggtt
ctatctacga 840ctccaccggt cgtctggttg cttctgttgc tcaggaaggt
ctgatgcgtc gcgttgaacg 900taagccgcgt aaaagctaag gatccgagct c
931119294PRTHyphomonas neptunium 119Met Ala Lys Asp Pro Val Gly Asp
Leu Leu Thr Leu Leu Asp Leu Glu 1 5 10 15 Arg Leu Glu Leu Asp Leu
Phe Arg Gly Gln Ser Pro Asp Glu Glu Glu 20 25 30 Ser Gln Arg Val
Phe Gly Gly Gln Val Ile Ala Gln Ser Leu Val Ala 35 40 45 Ala Tyr
Arg Thr Val Pro Asp Asp Arg Leu Cys His Ser Leu His Cys 50 55 60
Tyr Phe Ile Arg Pro Gly Asp Pro Ser Val Pro Ile Ile Tyr Gln Val 65
70 75 80 Asp His Ser Arg Asp Gly Gly Ser Phe Thr Thr Arg Arg Val
Val Ala 85 90 95 Ile Gln His Gly Lys Gln Ile Phe Asn Leu Ala Ala
Ser Phe His Val 100 105 110 Val Glu Asp Ser Trp His His Gln His Glu
Met Pro Glu Val Asp Pro 115 120 125 Pro Glu Ser Val Gly Asp Arg Ile
Glu Trp Arg Arg Lys Phe Ala Glu 130 135 140 Gln Val Pro Glu Arg His
Arg Gly His Phe Leu Arg Asp Arg Pro Val 145 150 155 160 Glu Met Arg
Glu Ile Asp Pro Leu Asp Pro Leu Lys Pro Ala Lys Ala 165 170 175 Ser
Asp Gln Gln Asn Leu Trp Phe Arg Val Ala Arg Pro Ile Asp Glu 180 185
190 Ala Pro Trp Leu His His Cys Leu Met Ala Tyr Ala Ser Asp Met Ala
195 200 205 Leu Leu Gly Thr Gly Asn Arg Pro His Gly Ile Ser Trp Met
Thr Gly 210 215 220 Glu Leu Met Ser Ala Ser Leu Asp His Ala Met Trp
Phe His Ala Pro 225 230 235 240 Thr Lys Phe Asp Glu Trp His Leu Tyr
Ser Met Asp Ser Pro Tyr Ala 245 250 255 Gly Gly Ala Arg Ser Phe Asn
Arg Gly Ser Ile Tyr Asp Ser Thr Gly 260 265 270 Arg Leu Val Ala Ser
Val Ala Gln Glu Gly Leu Met Arg Arg Val Glu 275 280 285 Arg Lys Pro
Arg Lys Ser 290 1201421DNAArtificialAcinetobacter sp. 120ggtacctttt
ttgggctaac aggaggaatt aaccatgatc aacaagatca tcaacgatat 60cgaaccgatt
ctgaaatcta tcccagacgg ttctaccatc atgacttctg gcttcggtac
120taccggtcag ccggaagcgc tgctggaagc gctgatcgac ttcgcaccga
aagagctgac 180tatcatcaac aacaacgctt cttccggtcc gaacggtctg
actcagctgt tcactgctgg 240tctggttaag aaactgatct gctcctaccc
gaaatctatc tcttccaccg ttttcccgga 300cctgtaccgc gctggtaaga
tcgaactgga actggttccg cagggtaacc tggcttgccg 360tatccaggca
gctggcgcgg gtctgggtgc agtattcact ccgactggtt acggtactaa
420gatcgctgaa ggtaaagaaa ctcgtatcat caacggtaaa aactacgttc
tggaataccc 480gctggaagct gactacgcat tcatctacgc tgacaaagct
gaccgctggg gtaacctgac 540ttaccgtaaa gcggcacgta acttcggtcc
gatcatggcg aaagcagcta aaaccactat 600tgctcaggtt aaccagactg
ttgaactggg cgatctggac ccggaatgca tcatcactcc 660gggtatcttc
gtacagcacg ttgttcgtct gggtgacatc aaataatttt ttgggctaac
720aggaggaatt aaccatgact attcagaagc gttctcgcga agatatcgct
atcatgatcg 780ctaaagacat cccggacggt tcttacgtta acctgggtat
cggtctgccg actcacgttg 840ctaaatatct gccgaaagac aaagaaatct
tcctgcactc tgaaaacggt gttctggcat 900tcggtccgcc gccagcagaa
ggtgaagaag atcaggacct ggttaacgct ggtaaagagc 960tggtaactct
gctgtctggt ggttgcttca tgcaccacgg tgactccttc gacatcatgc
1020gtggtggtca cctggatatc tgcgttatcg gtgcattcca ggttgcgctg
aacggtgacc 1080tggctaactg gcacaccggt aaagacgacg acgttccggc
agtaggtggt gcaatggacc 1140tggctgttgg tgcgaagcgt atcttcgttt
acatggaaca caccaccaag aaaggtgaac 1200cgaaaatcgt taagcacctg
acttacccga tcaccggtga acagtgcgta gaccgtatct 1260acactgacct
gtgcaccatc gaactgaaag acggtcaggc ttacgttatc gaaatggttg
1320acggtctgga tttcgacact ctgcaggcgc tgactgaatg cccgctgatc
gaccactgca 1380cctactcttc tctgattcag ctcagataag gatccgagct c
1421121223PRTAcinetobacter sp. 121Met Ile Asn Lys Ile Ile Asn Asp
Ile Glu Pro Ile Leu Lys Ser Ile 1 5 10 15 Pro Asp Gly Ser Thr Ile
Met Thr Ser Gly Phe Gly Thr Thr Gly Gln 20 25 30 Pro Glu Ala Leu
Leu Glu Ala Leu Ile Asp Phe Ala Pro Lys Glu Leu 35 40 45 Thr Ile
Ile Asn Asn Asn Ala Ser Ser Gly Pro Asn Gly Leu Thr Gln 50 55 60
Leu Phe Thr Ala Gly Leu Val Lys Lys Leu Ile Cys Ser Tyr Pro Lys 65
70 75 80 Ser Ile Ser Ser Thr Val Phe Pro Asp Leu Tyr Arg Ala Gly
Lys Ile 85 90 95 Glu Leu Glu Leu Val Pro Gln Gly Asn Leu Ala Cys
Arg Ile Gln Ala 100 105 110 Ala Gly Ala Gly Leu Gly Ala Val Phe Thr
Pro Thr Gly Tyr Gly Thr 115 120 125 Lys Ile Ala Glu Gly Lys Glu Thr
Arg Ile Ile Asn Gly Lys Asn Tyr 130 135 140 Val Leu Glu Tyr Pro Leu
Glu Ala Asp Tyr Ala Phe Ile Tyr Ala Asp 145 150 155 160 Lys Ala Asp
Arg Trp Gly Asn Leu Thr Tyr Arg Lys Ala Ala Arg Asn 165 170 175 Phe
Gly Pro Ile Met Ala Lys Ala Ala Lys Thr Thr Ile Ala Gln Val 180 185
190 Asn Gln Thr Val Glu Leu Gly Asp Leu Asp Pro Glu Cys Ile Ile Thr
195 200 205 Pro Gly Ile Phe Val Gln His Val Val Arg Leu Gly Asp Ile
Lys 210 215 220 122224PRTAcinetobacter sp. 122Met Thr Ile Gln Lys
Arg Ser Arg Glu Asp Ile Ala Ile Met Ile Ala 1 5 10 15 Lys Asp Ile
Pro Asp Gly Ser Tyr Val Asn Leu Gly Ile Gly Leu Pro 20 25 30 Thr
His Val Ala Lys Tyr Leu Pro Lys Asp Lys Glu Ile Phe Leu His 35 40
45 Ser Glu Asn Gly Val Leu Ala Phe Gly Pro Pro Pro Ala Glu Gly Glu
50 55 60 Glu Asp Gln Asp Leu Val Asn Ala Gly Lys Glu Leu Val Thr
Leu Leu 65 70
75 80 Ser Gly Gly Cys Phe Met His His Gly Asp Ser Phe Asp Ile Met
Arg 85 90 95 Gly Gly His Leu Asp Ile Cys Val Ile Gly Ala Phe Gln
Val Ala Leu 100 105 110 Asn Gly Asp Leu Ala Asn Trp His Thr Gly Lys
Asp Asp Asp Val Pro 115 120 125 Ala Val Gly Gly Ala Met Asp Leu Ala
Val Gly Ala Lys Arg Ile Phe 130 135 140 Val Tyr Met Glu His Thr Thr
Lys Lys Gly Glu Pro Lys Ile Val Lys 145 150 155 160 His Leu Thr Tyr
Pro Ile Thr Gly Glu Gln Cys Val Asp Arg Ile Tyr 165 170 175 Thr Asp
Leu Cys Thr Ile Glu Leu Lys Asp Gly Gln Ala Tyr Val Ile 180 185 190
Glu Met Val Asp Gly Leu Asp Phe Asp Thr Leu Gln Ala Leu Thr Glu 195
200 205 Cys Pro Leu Ile Asp His Cys Thr Tyr Ser Ser Leu Ile Gln Leu
Arg 210 215 220 123437PRTClostridium kluyveri 123Met Val Phe Lys
Asn Trp Gln Asp Leu Tyr Lys Ser Lys Ile Val Ser 1 5 10 15 Ala Asp
Glu Ala Val Ser Lys Val Ser Cys Gly Asp Ser Ile Ile Leu 20 25 30
Gly Asn Ala Cys Gly Ala Ser Leu Thr Leu Leu Asp Ala Leu Ala Ala 35
40 45 Asn Lys Glu Lys Tyr Lys Ser Val Lys Ile His Asn Leu Ile Leu
Asn 50 55 60 Tyr Lys Asn Asp Ile Tyr Thr Asp Pro Glu Ser Glu Lys
Tyr Ile His 65 70 75 80 Gly Asn Thr Phe Phe Val Ser Gly Gly Thr Lys
Glu Ala Val Asn Cys 85 90 95 Asn Arg Thr Asp Tyr Thr Pro Cys Phe
Phe Tyr Glu Ile Pro Lys Leu 100 105 110 Leu Lys Gln Lys Tyr Ile Asn
Ala Asp Val Ala Phe Ile Gln Val Ser 115 120 125 Lys Pro Asp Ser His
Gly Tyr Cys Ser Phe Gly Val Ser Thr Asp Tyr 130 135 140 Ser Gln Ala
Met Val Gln Ser Ala Lys Leu Ile Ile Ala Glu Val Asn 145 150 155 160
Asp Gln Met Pro Arg Val Leu Gly Asp Asn Phe Ile His Ile Ser Asp 165
170 175 Met Asp Tyr Ile Val Glu Ser Ser Arg Pro Ile Leu Glu Leu Thr
Pro 180 185 190 Pro Lys Ile Gly Glu Val Glu Lys Thr Ile Gly Lys Tyr
Cys Ala Ser 195 200 205 Leu Val Glu Asp Gly Ser Thr Leu Gln Leu Gly
Ile Gly Ala Ile Pro 210 215 220 Asp Ala Val Leu Leu Phe Leu Lys Asp
Lys Lys Asp Leu Gly Ile His 225 230 235 240 Ser Glu Met Ile Ser Asp
Gly Val Val Glu Leu Val Glu Ala Gly Val 245 250 255 Ile Thr Asn Lys
Lys Lys Ser Leu His Pro Gly Lys Ile Ile Ile Thr 260 265 270 Phe Leu
Met Gly Thr Lys Lys Leu Tyr Asp Phe Ile Asn Asp Asn Pro 275 280 285
Met Val Glu Gly Tyr Pro Val Asp Tyr Val Asn Asp Pro Lys Val Ile 290
295 300 Met Gln Asn Ser Lys Met Val Cys Ile Asn Ser Cys Val Glu Val
Asp 305 310 315 320 Phe Thr Gly Gln Val Cys Ala Glu Ser Val Gly Phe
Lys Gln Ile Ser 325 330 335 Gly Val Gly Gly Gln Val Asp Tyr Met Arg
Gly Ala Ser Met Ala Asp 340 345 350 Gly Gly Lys Ser Ile Leu Ala Ile
Pro Ser Thr Ala Ala Gly Gly Lys 355 360 365 Ile Ser Arg Ile Val Pro
Ile Leu Thr Glu Gly Ala Gly Val Thr Thr 370 375 380 Ser Arg Tyr Asp
Val Gln Tyr Val Val Thr Glu Tyr Gly Ile Ala Leu 385 390 395 400 Leu
Lys Gly Lys Ser Ile Arg Glu Arg Ala Lys Glu Leu Ile Lys Ile 405 410
415 Ala His Pro Lys Phe Arg Glu Glu Leu Thr Ala Gln Phe Glu Lys Arg
420 425 430 Phe Ser Cys Lys Leu 435 124538PRTClostridium kluyveri
124Met Ser Lys Gly Ile Lys Asn Ser Gln Leu Lys Lys Lys Asn Val Lys
1 5 10 15 Ala Ser Asn Val Ala Glu Lys Ile Glu Glu Lys Val Glu Lys
Thr Asp 20 25 30 Lys Val Val Glu Lys Ala Ala Glu Val Thr Glu Lys
Arg Ile Arg Asn 35 40 45 Leu Lys Leu Gln Glu Lys Val Val Thr Ala
Asp Val Ala Ala Asp Met 50 55 60 Ile Glu Asn Gly Met Ile Val Ala
Ile Ser Gly Phe Thr Pro Ser Gly 65 70 75 80 Tyr Pro Lys Glu Val Pro
Lys Ala Leu Thr Lys Lys Val Asn Ala Leu 85 90 95 Glu Glu Glu Phe
Lys Val Thr Leu Tyr Thr Gly Ser Ser Thr Gly Ala 100 105 110 Asp Ile
Asp Gly Glu Trp Ala Lys Ala Gly Ile Ile Glu Arg Arg Ile 115 120 125
Pro Tyr Gln Thr Asn Ser Asp Met Arg Lys Lys Ile Asn Asp Gly Ser 130
135 140 Ile Lys Tyr Ala Asp Met His Leu Ser His Met Ala Gln Tyr Ile
Asn 145 150 155 160 Tyr Ser Val Ile Pro Lys Val Asp Ile Ala Ile Ile
Glu Ala Val Ala 165 170 175 Ile Thr Glu Glu Gly Asp Ile Ile Pro Ser
Thr Gly Ile Gly Asn Thr 180 185 190 Ala Thr Phe Val Glu Asn Ala Asp
Lys Val Ile Val Glu Ile Asn Glu 195 200 205 Ala Gln Pro Leu Glu Leu
Glu Gly Met Ala Asp Ile Tyr Thr Leu Lys 210 215 220 Asn Pro Pro Arg
Arg Glu Pro Ile Pro Ile Val Asn Ala Gly Asn Arg 225 230 235 240 Ile
Gly Thr Thr Tyr Val Thr Cys Gly Ser Glu Lys Ile Cys Ala Ile 245 250
255 Val Met Thr Asn Thr Gln Asp Lys Thr Arg Pro Leu Thr Glu Val Ser
260 265 270 Pro Val Ser Gln Ala Ile Ser Asp Asn Leu Ile Gly Phe Leu
Asn Lys 275 280 285 Glu Val Glu Glu Gly Lys Leu Pro Lys Asn Leu Leu
Pro Ile Gln Ser 290 295 300 Gly Val Gly Ser Val Ala Asn Ala Val Leu
Ala Gly Leu Cys Glu Ser 305 310 315 320 Asn Phe Lys Asn Leu Ser Cys
Tyr Thr Glu Val Ile Gln Asp Ser Met 325 330 335 Leu Lys Leu Ile Lys
Cys Gly Lys Ala Asp Val Val Ser Gly Thr Ser 340 345 350 Ile Ser Pro
Ser Pro Glu Met Leu Pro Glu Phe Ile Lys Asp Ile Asn 355 360 365 Phe
Phe Arg Glu Lys Ile Val Leu Arg Pro Gln Glu Ile Ser Asn Asn 370 375
380 Pro Glu Ile Ala Arg Arg Ile Gly Val Ile Ser Ile Asn Thr Ala Leu
385 390 395 400 Glu Val Asp Ile Tyr Gly Asn Val Asn Ser Thr His Val
Met Gly Ser 405 410 415 Lys Met Met Asn Gly Ile Gly Gly Ser Gly Asp
Phe Ala Arg Asn Ala 420 425 430 Tyr Leu Thr Ile Phe Thr Thr Glu Ser
Ile Ala Lys Lys Gly Asp Ile 435 440 445 Ser Ser Ile Val Pro Met Val
Ser His Val Asp His Thr Glu His Asp 450 455 460 Val Met Val Ile Val
Thr Glu Gln Gly Val Ala Asp Leu Arg Gly Leu 465 470 475 480 Ser Pro
Arg Glu Lys Ala Val Ala Ile Ile Glu Asn Cys Val His Pro 485 490 495
Asp Tyr Lys Asp Met Leu Met Glu Tyr Phe Glu Glu Ala Cys Lys Ser 500
505 510 Ser Gly Gly Asn Thr Pro His Asn Leu Glu Lys Ala Leu Ser Trp
His 515 520 525 Thr Lys Phe Ile Lys Thr Gly Ser Met Lys 530 535
125232PRTPseudomonas fluorescens 125Met Ala Gly Phe Asp Lys Arg Val
Ala Ser Tyr Glu Glu Ala Leu Glu 1 5 10 15 Gly Leu Gln Asp Gly Met
Thr Val Ile Ala Gly Gly Phe Gly Leu Cys 20 25 30 Gly Ile Pro Glu
Asn Leu Ile Ala Glu Ile Lys Arg Arg Gly Thr Arg 35 40 45 Asp Leu
Thr Val Val Ser Asn Asn Cys Gly Val Asp Gly Phe Gly Leu 50 55 60
Gly Val Leu Leu Glu Asp Arg Gln Ile Ser Lys Val Ile Ala Ser Tyr 65
70 75 80 Val Gly Glu Asn Ala Leu Phe Glu Lys Gln Leu Leu Ser Gly
Glu Ile 85 90 95 Glu Val Val Leu Thr Pro Gln Gly Thr Leu Ala Glu
Lys Met Arg Ala 100 105 110 Gly Gly Ala Gly Ile Pro Ala Phe Phe Thr
Ala Thr Gly Val Gly Thr 115 120 125 Pro Val Ala Asp Gly Lys Glu Thr
Arg Glu Phe Lys Gly Arg Thr Tyr 130 135 140 Leu Met Glu Glu Ser Ile
Thr Gly Asp Phe Ala Ile Val Lys Gly Trp 145 150 155 160 Lys Ala Asp
His Phe Gly Asn Val Val Tyr Arg His Thr Ala Gln Asn 165 170 175 Phe
Asn Pro Leu Ala Ala Thr Ala Gly Lys Ile Thr Val Val Glu Val 180 185
190 Glu Glu Ile Val Glu Pro Gly Glu Leu Asp Pro Thr Gln Ile His Thr
195 200 205 Pro Gly Ile Tyr Val Asp Arg Val Ile Cys Gly Thr Phe Glu
Lys Arg 210 215 220 Ile Glu Gln Arg Thr Val Arg Lys 225 230
126219PRTPseudomonas fluorescens 126Met Ala Leu Thr Arg Glu Gln Met
Ala Gln Arg Val Ala Arg Glu Leu 1 5 10 15 Gln Asp Gly Phe Tyr Val
Asn Leu Gly Ile Gly Ile Pro Thr Leu Val 20 25 30 Ala Asn Tyr Ile
Pro Asp Gly Met Glu Val Met Leu Gln Ser Glu Asn 35 40 45 Gly Leu
Leu Gly Met Gly Ala Phe Pro Thr Glu Asp Glu Val Asp Ala 50 55 60
Asp Met Ile Asn Ala Gly Lys Gln Thr Val Thr Ala Arg Ile Gly Ala 65
70 75 80 Ser Ile Phe Ser Ser Ala Glu Ser Phe Ala Met Ile Arg Gly
Gly His 85 90 95 Ile Asp Leu Thr Val Leu Gly Ala Phe Glu Val Asp
Val Gln Gly Asn 100 105 110 Ile Ala Ser Trp Met Ile Pro Gly Lys Leu
Val Lys Gly Met Gly Gly 115 120 125 Ala Met Asp Leu Val Ala Gly Ala
Glu Asn Ile Ile Val Thr Met Thr 130 135 140 His Ala Ser Lys Asp Gly
Glu Ser Lys Leu Leu Ser Arg Cys Ser Leu 145 150 155 160 Pro Leu Thr
Gly Ala Gln Cys Ile Lys Arg Val Leu Thr Asp Leu Ala 165 170 175 Tyr
Leu Glu Ile Glu Asn Gly Ala Phe Ile Leu Lys Glu Arg Ala Pro 180 185
190 Gly Val Ser Val Glu Glu Ile Val Ser Lys Thr Ala Gly Lys Leu Ile
195 200 205 Val Pro Asp His Val Pro Glu Met Gln Phe Ala 210 215
127477PRTAcinetobacter sp. 127Met Asn Tyr Pro Asn Ile Pro Leu Tyr
Ile Asn Gly Glu Phe Leu Asp 1 5 10 15 His Thr Asn Arg Asp Val Lys
Glu Val Phe Asn Pro Val Asn His Glu 20 25 30 Cys Ile Gly Leu Met
Ala Cys Ala Ser Gln Ala Asp Leu Asp Tyr Ala 35 40 45 Leu Glu Ser
Ser Gln Gln Ala Phe Leu Arg Trp Lys Lys Thr Ser Pro 50 55 60 Ile
Thr Arg Ser Glu Ile Leu Arg Thr Phe Ala Lys Leu Ala Arg Glu 65 70
75 80 Lys Ala Ala Glu Ile Gly Arg Asn Ile Thr Leu Asp Gln Gly Lys
Pro 85 90 95 Leu Lys Glu Ala Ile Ala Glu Val Thr Val Cys Ala Glu
His Ala Glu 100 105 110 Trp His Ala Glu Glu Cys Arg Arg Ile Tyr Gly
Arg Val Ile Pro Pro 115 120 125 Arg Asn Pro Asn Val Gln Gln Leu Val
Val Arg Glu Pro Leu Gly Val 130 135 140 Cys Leu Ala Phe Ser Pro Trp
Asn Phe Pro Phe Asn Gln Ala Ile Arg 145 150 155 160 Lys Ile Ser Ala
Ala Ile Ala Ala Gly Cys Thr Ile Ile Val Lys Gly 165 170 175 Ser Gly
Asp Thr Pro Ser Ala Val Tyr Ala Ile Ala Gln Leu Phe His 180 185 190
Glu Ala Gly Leu Pro Asn Gly Val Leu Asn Val Ile Trp Gly Asp Ser 195
200 205 Asn Phe Ile Ser Asp Tyr Met Ile Lys Ser Pro Ile Ile Gln Lys
Ile 210 215 220 Ser Phe Thr Gly Ser Thr Pro Val Gly Lys Lys Leu Ala
Ser Gln Ala 225 230 235 240 Ser Leu Tyr Met Lys Pro Cys Thr Met Glu
Leu Gly Gly His Ala Pro 245 250 255 Val Ile Val Cys Asp Asp Ala Asp
Ile Asp Ala Ala Val Glu His Leu 260 265 270 Val Gly Tyr Lys Phe Arg
Asn Ala Gly Gln Val Cys Val Ser Pro Thr 275 280 285 Arg Phe Tyr Val
Gln Glu Gly Ile Tyr Lys Glu Phe Ser Glu Lys Val 290 295 300 Val Leu
Arg Ala Lys Gln Ile Lys Val Gly Cys Gly Leu Asp Ala Ser 305 310 315
320 Ser Asp Met Gly Pro Leu Ala Gln Ala Arg Arg Met His Ala Met Gln
325 330 335 Gln Ile Val Glu Asp Ala Val His Lys Gly Ser Lys Leu Leu
Leu Gly 340 345 350 Gly Asn Lys Ile Ser Asp Lys Gly Asn Phe Phe Glu
Pro Thr Val Leu 355 360 365 Gly Asp Leu Cys Asn Asp Thr Gln Phe Met
Asn Asp Glu Pro Phe Gly 370 375 380 Pro Ile Ile Gly Leu Ile Pro Phe
Asp Thr Ile Asp His Val Leu Glu 385 390 395 400 Glu Ala Asn Arg Leu
Pro Phe Gly Leu Ala Ser Tyr Ala Phe Thr Thr 405 410 415 Ser Ser Lys
Asn Ala His Gln Ile Ser Tyr Gly Leu Glu Ala Gly Met 420 425 430 Val
Ser Ile Asn His Met Gly Leu Ala Leu Ala Glu Thr Pro Phe Gly 435 440
445 Gly Ile Lys Asp Ser Gly Phe Gly Ser Glu Gly Gly Ile Glu Thr Phe
450 455 460 Asp Gly Tyr Leu Arg Thr Lys Phe Ile Thr Gln Leu Asn 465
470 475 128473PRTBrucella melitensis 128Met Arg Ile Gly Lys Met Glu
Met Gln Thr Arg Tyr Pro Asp Val Lys 1 5 10 15 Leu Phe Ile Asp Gly
Thr Trp Arg Asp Gly Ser Arg Gly Glu Thr Ile 20 25 30 Glu Ile Phe
Asn Pro Ala Thr Asp Glu Val Ile Gly His Ile Ala Arg 35 40 45 Ala
Thr Thr Ala Asp Leu Asp Asp Ala Leu Ala Ala Val Asp Arg Gly 50 55
60 Phe Glu Ala Trp Ser Lys Val Ser Ala Phe Asp Arg Tyr Lys Ile Met
65 70 75 80 Arg Arg Ala Ala Asp Ile Phe Arg Ser Arg Gly Glu Glu Val
Ala Arg 85 90 95 Leu Leu Thr Met Glu Gln Gly Lys Pro Leu Ala Glu
Ala Arg Ile Glu 100 105 110 Ala Ala Ala Ala Cys Asp Leu Ile Asp Trp
Phe Ala Glu Glu Ala Arg 115 120 125 Arg Ser Tyr Gly Arg Ile Val Pro
Pro Arg Gln Ala Tyr Val Met Gln 130 135 140 Ala Glu Val Lys Glu Pro
Val Gly Pro Val Ala Ala Phe Thr Pro Trp 145 150 155 160 Asn Phe Pro
Ile Asn Gln Ala Val Arg Lys Ile Ser Ala Ala Leu Ala 165 170 175 Ala
Gly Cys Ser Ile Leu Leu Lys Ala Ala Glu Asp Thr Pro Ala Ala 180 185
190 Pro Ala Glu Leu Val Arg Ala Phe Ala Glu Ala Gly Leu Pro Asp Gly
195 200 205 Ala Ile Asn Leu Val Tyr Gly Asp Pro Ala Glu Ile Ser Ala
Tyr Leu 210 215 220 Ile Pro His Pro Val Ile
Arg Lys Val Ser Phe Thr Gly Ser Thr Gln 225 230 235 240 Val Gly Lys
Gln Leu Ala Ala Leu Ala Gly Leu His Met Lys Arg Val 245 250 255 Thr
Met Glu Leu Gly Gly His Ala Pro Val Ile Ile Ala Ala Asp Ala 260 265
270 Asp Val Glu Gln Ala Ile Lys Val Val Ser Gly Ser Lys Phe Arg Asn
275 280 285 Ala Gly Gln Val Cys Ile Ser Pro Thr Arg Phe Leu Ile Glu
Asn Ser 290 295 300 Val Tyr Asp Gln Val Val Glu Gly Met Ala Ala Tyr
Ala Thr Ser Leu 305 310 315 320 Lys Val Gly Asp Gly Leu Glu Ala Gly
Thr Thr Met Gly Pro Leu Val 325 330 335 Asn Ala Lys Arg Val Asn Ala
Met Glu Arg Leu Val Gln Asp Ala Arg 340 345 350 Glu His Lys Ala Arg
Val Val Thr Gly Gly Glu Arg Ile Gly Asn Arg 355 360 365 Gly Asn Phe
Phe Glu Pro Thr Ile Leu Ala Asp Val Pro Arg Asp Ala 370 375 380 Ala
Ile Met Asn Glu Glu Pro Phe Gly Pro Val Ala Leu Leu Asn Arg 385 390
395 400 Phe Asp Ala Leu Asp Glu Ala Leu Ser Glu Ala Asn Arg Leu Asn
Tyr 405 410 415 Gly Leu Ala Ala Tyr Ala Phe Thr Gly Ser Ser Ala Lys
Ala Ala Arg 420 425 430 Ile Ser Ser Thr Val Arg Ser Gly Met Ile Thr
Ile Asn Gln Leu Arg 435 440 445 Ser Gly Pro Ala Gly Ser Ala Leu Arg
Arg Asp Gln Arg Phe Arg Leu 450 455 460 Trp Asn Gly Arg Arg Cys Arg
Arg Ala 465 470 1291371DNAArtificialPseudomonas aeruginosa
129atgaacagcc aaatcaccaa cgccaagacc cgtgagtggc aggcgttgag
ccgcgaccac 60catctgccgc cgttcaccga ctacaagcag ttgaacgaga agggcgcgcg
gatcatcacc 120aaggccgaag gcgtctatat ctgggacagc gagggcaaca
agatcctcga tgcgatggcc 180ggcctctggt gcgtcaacgt cggctacggc
cgcgaggagc tggtccaggc cgccacccgg 240cagatgcgcg agttgccgtt
ctacaacctg ttcttccaga ccgcccaccc gccggtggtc 300gagctggcca
aggcgatcgc cgacgtcgct ccggaaggca tgaaccacgt gttcttcacc
360ggctccggct ccgaggccaa cgacaccgtg ctgcgtatgg tccgccacta
ttgggcgacc 420aagggccagc cgcagaagaa agtggtgatc ggccgctgga
acggctacca cggctccacc 480gtcgccggcg tcagcctggg cggcatgaag
gcgttgcatg agcagggtga tttccccatc 540ccgggcatcg tccacatcgc
ccagccctac tggtacggcg agggcggcga catgtcgccg 600gacgagttcg
gcgtctgggc cgccgagcag ttggagaaga agattctcga agtgggcgag
660gaaaacgtcg ccgccttcat cgccgagccg atccagggcg ccggcggcgt
gatcgtcccg 720ccggacacct actggccgaa gatccgcgag atcctcgcca
agtacgacat cctgttcatc 780gccgacgaag tgatctgcgg cttcggccgt
accggcgagt ggttcggcag ccagtactac 840ggcaacgccc cggacctgat
gccgatcgcc aagggcctca cctccggcta catccccatg 900ggcggggtgg
tggtgcgcga cgagatcgtc gaagtgctca accagggcgg cgagttctac
960cacggcttca cctattccgg tcacccggtg gcggccgccg tggccctgga
gaacatccgc 1020atcctgcgcg aagagaagat catcgagaag gtgaaggcgg
aaacggcacc gtatttgcag 1080aaacgctggc aggagctggc cgaccacccg
ttggtgggcg aagcgcgcgg ggtcggcatg 1140gtcgccgccc tggagctggt
caagaacaag aagacccgcg agcgtttcac cgacaagggc 1200gtcgggatgc
tgtgccggga acattgtttc cgcaacggtt tgatcatgcg cgcggtgggc
1260gacactatga ttatctcgcc gccgctggtg atcgatccgt cgcagatcga
tgagttgatc 1320accctggcgc gcaagtgcct cgatcagacc gccgccgccg
tcctggcttg a 1371130456PRTPseudomonas aeruginosa 130Met Asn Ser Gln
Ile Thr Asn Ala Lys Thr Arg Glu Trp Gln Ala Leu 1 5 10 15 Ser Arg
Asp His His Leu Pro Pro Phe Thr Asp Tyr Lys Gln Leu Asn 20 25 30
Glu Lys Gly Ala Arg Ile Ile Thr Lys Ala Glu Gly Val Tyr Ile Trp 35
40 45 Asp Ser Glu Gly Asn Lys Ile Leu Asp Ala Met Ala Gly Leu Trp
Cys 50 55 60 Val Asn Val Gly Tyr Gly Arg Glu Glu Leu Val Gln Ala
Ala Thr Arg 65 70 75 80 Gln Met Arg Glu Leu Pro Phe Tyr Asn Leu Phe
Phe Gln Thr Ala His 85 90 95 Pro Pro Val Val Glu Leu Ala Lys Ala
Ile Ala Asp Val Ala Pro Glu 100 105 110 Gly Met Asn His Val Phe Phe
Thr Gly Ser Gly Ser Glu Ala Asn Asp 115 120 125 Thr Val Leu Arg Met
Val Arg His Tyr Trp Ala Thr Lys Gly Gln Pro 130 135 140 Gln Lys Lys
Val Val Ile Gly Arg Trp Asn Gly Tyr His Gly Ser Thr 145 150 155 160
Val Ala Gly Val Ser Leu Gly Gly Met Lys Ala Leu His Glu Gln Gly 165
170 175 Asp Phe Pro Ile Pro Gly Ile Val His Ile Ala Gln Pro Tyr Trp
Tyr 180 185 190 Gly Glu Gly Gly Asp Met Ser Pro Asp Glu Phe Gly Val
Trp Ala Ala 195 200 205 Glu Gln Leu Glu Lys Lys Ile Leu Glu Val Gly
Glu Glu Asn Val Ala 210 215 220 Ala Phe Ile Ala Glu Pro Ile Gln Gly
Ala Gly Gly Val Ile Val Pro 225 230 235 240 Pro Asp Thr Tyr Trp Pro
Lys Ile Arg Glu Ile Leu Ala Lys Tyr Asp 245 250 255 Ile Leu Phe Ile
Ala Asp Glu Val Ile Cys Gly Phe Gly Arg Thr Gly 260 265 270 Glu Trp
Phe Gly Ser Gln Tyr Tyr Gly Asn Ala Pro Asp Leu Met Pro 275 280 285
Ile Ala Lys Gly Leu Thr Ser Gly Tyr Ile Pro Met Gly Gly Val Val 290
295 300 Val Arg Asp Glu Ile Val Glu Val Leu Asn Gln Gly Gly Glu Phe
Tyr 305 310 315 320 His Gly Phe Thr Tyr Ser Gly His Pro Val Ala Ala
Ala Val Ala Leu 325 330 335 Glu Asn Ile Arg Ile Leu Arg Glu Glu Lys
Ile Ile Glu Lys Val Lys 340 345 350 Ala Glu Thr Ala Pro Tyr Leu Gln
Lys Arg Trp Gln Glu Leu Ala Asp 355 360 365 His Pro Leu Val Gly Glu
Ala Arg Gly Val Gly Met Val Ala Ala Leu 370 375 380 Glu Leu Val Lys
Asn Lys Lys Thr Arg Glu Arg Phe Thr Asp Lys Gly 385 390 395 400 Val
Gly Met Leu Cys Arg Glu His Cys Phe Arg Asn Gly Leu Ile Met 405 410
415 Arg Ala Val Gly Asp Thr Met Ile Ile Ser Pro Pro Leu Val Ile Asp
420 425 430 Pro Ser Gln Ile Asp Glu Leu Ile Thr Leu Ala Arg Lys Cys
Leu Asp 435 440 445 Gln Thr Ala Ala Ala Val Leu Ala 450 455
13170DNAArtificialprimer 131ggggacaagt ttgtacaaaa aagcaggcta
ggaggaatta accatgaaca gccaaatcac 60caacgccaag
7013249DNAArtificialprimer 132ggggaccact ttgtacaaga aagctgggtt
caagccagga cggcggcgg 491331353DNAArtificialBacillus subtilis
133atggagatga tggggatgga aaacattcag caaaatcagg gattaaagca
aaaagatgag 60caatttgtgt ggcatgccat gaagggagcg catcaagcgg acagcctgat
agcccagaag 120gccgaagggg cctgggtaac cgacacagac ggacgccgct
atttggatgc gatgtccggt 180ttgtggtgcg tcaacattgg ttacggcaga
aaggagcttg cggaggctgc ctatgagcaa 240ctaaaggagc tgccttacta
cccgttaacg caaagtcacg cacccgcaat tcaactggcg 300gaaaagctga
atgaatggct tggcggcgat tatgttattt ttttttccaa cagcggatcg
360gaagcaaacg aaactgcttt taaaattgcc cgccagtacc atctgcaaaa
cggcgaccac 420agccgttata aattcatctc aagatatcgg gcataccacg
gcaatacatt gggagcgctc 480tcagctaccg gacaggcgca gcggaaatat
aaatacgagc ctttgagcca agggttcctg 540catgcagctc cgccagatat
ataccggaat cctgatgatg cagacacgct tgaaagcgca 600aatgaaatcg
accgcatcat gacatgggaa ttaagcgaaa cgattgccgg ggtcattatg
660gagcccatca ttacaggcgg aggcatccta atgccgccgg acggatatat
gaagaaggtg 720gaggacattt gccggcgcca cggagccctt ttgatttgcg
atgaagtgat ctgcgggttt 780ggacggacag gtgagccgtt cgggtttatg
cactacggtg tgaagcctga tatcattacg 840atggcaaagg gaatcacaag
cgcgtatctg ccattgtcag cgactgctgt gaaacgggac 900attttcgaag
cgtatcaggg ggaagctcct tatgaccgtt tccgccacgt gaacacgttc
960ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc tgcaaattat
ggaggacgaa 1020cagctgattc agcgatcccg tgatcttgga gcaaagcttt
taggtgagct tcaagctctg 1080agagaacacc cggcagtcgg ggatgttaga
ggaaaagggc tgctgatcgg aatcgaactc 1140gtcaaagaca aattgactaa
agagccggct gatgccgcca aagtaaacca agtggttgcg 1200gcgtgcaaag
aaaaagggct gatcatcggc aaaaacggcg atacagtcgc cggctacaac
1260aatgtcatcc acgttgcgcc gccattttgc ctgacagaag aggacctttc
ctttatcgtg 1320aaaacggtga aagaaagctt tcaaacgata taa
1353134450PRTBacillus subtilis 134Met Glu Met Met Gly Met Glu Asn
Ile Gln Gln Asn Gln Gly Leu Lys 1 5 10 15 Gln Lys Asp Glu Gln Phe
Val Trp His Ala Met Lys Gly Ala His Gln 20 25 30 Ala Asp Ser Leu
Ile Ala Gln Lys Ala Glu Gly Ala Trp Val Thr Asp 35 40 45 Thr Asp
Gly Arg Arg Tyr Leu Asp Ala Met Ser Gly Leu Trp Cys Val 50 55 60
Asn Ile Gly Tyr Gly Arg Lys Glu Leu Ala Glu Ala Ala Tyr Glu Gln 65
70 75 80 Leu Lys Glu Leu Pro Tyr Tyr Pro Leu Thr Gln Ser His Ala
Pro Ala 85 90 95 Ile Gln Leu Ala Glu Lys Leu Asn Glu Trp Leu Gly
Gly Asp Tyr Val 100 105 110 Ile Phe Phe Ser Asn Ser Gly Ser Glu Ala
Asn Glu Thr Ala Phe Lys 115 120 125 Ile Ala Arg Gln Tyr His Leu Gln
Asn Gly Asp His Ser Arg Tyr Lys 130 135 140 Phe Ile Ser Arg Tyr Arg
Ala Tyr His Gly Asn Thr Leu Gly Ala Leu 145 150 155 160 Ser Ala Thr
Gly Gln Ala Gln Arg Lys Tyr Lys Tyr Glu Pro Leu Ser 165 170 175 Gln
Gly Phe Leu His Ala Ala Pro Pro Asp Ile Tyr Arg Asn Pro Asp 180 185
190 Asp Ala Asp Thr Leu Glu Ser Ala Asn Glu Ile Asp Arg Ile Met Thr
195 200 205 Trp Glu Leu Ser Glu Thr Ile Ala Gly Val Ile Met Glu Pro
Ile Ile 210 215 220 Thr Gly Gly Gly Ile Leu Met Pro Pro Asp Gly Tyr
Met Lys Lys Val 225 230 235 240 Glu Asp Ile Cys Arg Arg His Gly Ala
Leu Leu Ile Cys Asp Glu Val 245 250 255 Ile Cys Gly Phe Gly Arg Thr
Gly Glu Pro Phe Gly Phe Met His Tyr 260 265 270 Gly Val Lys Pro Asp
Ile Ile Thr Met Ala Lys Gly Ile Thr Ser Ala 275 280 285 Tyr Leu Pro
Leu Ser Ala Thr Ala Val Lys Arg Asp Ile Phe Glu Ala 290 295 300 Tyr
Gln Gly Glu Ala Pro Tyr Asp Arg Phe Arg His Val Asn Thr Phe 305 310
315 320 Gly Gly Ser Pro Ala Ala Cys Ala Leu Ala Leu Lys Asn Leu Gln
Ile 325 330 335 Met Glu Asp Glu Gln Leu Ile Gln Arg Ser Arg Asp Leu
Gly Ala Lys 340 345 350 Leu Leu Gly Glu Leu Gln Ala Leu Arg Glu His
Pro Ala Val Gly Asp 355 360 365 Val Arg Gly Lys Gly Leu Leu Ile Gly
Ile Glu Leu Val Lys Asp Lys 370 375 380 Leu Thr Lys Glu Pro Ala Asp
Ala Ala Lys Val Asn Gln Val Val Ala 385 390 395 400 Ala Cys Lys Glu
Lys Gly Leu Ile Ile Gly Lys Asn Gly Asp Thr Val 405 410 415 Ala Gly
Tyr Asn Asn Val Ile His Val Ala Pro Pro Phe Cys Leu Thr 420 425 430
Glu Glu Asp Leu Ser Phe Ile Val Lys Thr Val Lys Glu Ser Phe Gln 435
440 445 Thr Ile 450 1351407DNAArtificialPseudomonas aeruginosa
135atgaacgcaa gactgcacgc cacgtccccc ctcggcgacg ccgacctggt
ccgtgccgac 60caggcccact acatgcacgg ctaccacgtg ttcgacgacc accgcgtcaa
cggctcgctg 120aacatcgccg ccggcgacgg cgcctatatc tacgacaccg
ccggcaaccg ctacctcgac 180gcggtgggcg gcatgtggtg caccaacatc
ggcctggggc gcgaggaaat ggctcgcacc 240gtggccgagc agacccgcct
gctggcctat tccaatccct tctgcgacat ggccaacccg 300cgcgccatcg
aactctgccg caagctcgcc gagctggccc ccggcgacct cgaccacgtg
360ttcctcacca ccggcggttc caccgccgtg gacaccgcga tccgcctcat
gcactactac 420cagaactgcc gcggcaagcg cgccaagaag cacgtcatca
cgcggatcaa cgcctaccac 480ggctcgacct tcctcggcat gtcgctgggc
ggcaagagcg ccgaccggcc ggccgagttc 540gacttcctcg acgagcgcat
ccaccacctc gcctgtccct attactaccg cgctccggaa 600gggctgggcg
aagccgagtt cctcgatggc ctggtggacg agttcgaacg caagatcctc
660gaactgggcg ccgaccgggt gggggcgttc atctccgagc cggtgttcgg
ctccggcggc 720gtgatcgtcc cgcccgcggg ctaccacagg cggatgtggg
agctgtgcca gcgctacgac 780gtgctgtaca tctccgacga agtggtgacc
tccttcggcc gcctcggcca cttcttcgcc 840agccaggcgg tgttcggcgt
acagccggac atcatcctca ccgccaaggg cctcacctcc 900ggctaccagc
cgctgggcgc gtgcatcttc tcccggcgca tctgggaggt gatcgccgag
960ccggacaagg gccgctgctt cagccatggt ttcacctact ccggccaccc
ggtggcctgc 1020gcggcggcgc tgaagaacat cgagatcatc gagcgcgagg
gcttgctcgc ccacgccgac 1080gaggtcggcc gctacttcga ggagcgcctg
caaagcctcc gcgacctgcc catcgtcggc 1140gacgtgcgcg ggatgcgctt
catggcctgt gtcgagttcg tcgccgacaa ggcgagcaag 1200gcgctgtttc
cggaaagcct gaacatcggc gagtgggtcc acctgcgggc gcagaagcgc
1260ggcctgctgg ttcgtccgat cgtccacctg aacgtgatgt cgccgccgct
gatcctcacc 1320cgcgaacagg tcgataccgt ggtccgggtg ctgcgcgaga
gcatcgagga aaccgtggag 1380gatcttgtcc gcgccggtca ccggtaa
1407136468PRTPseudomonas aeruginosa 136Met Asn Ala Arg Leu His Ala
Thr Ser Pro Leu Gly Asp Ala Asp Leu 1 5 10 15 Val Arg Ala Asp Gln
Ala His Tyr Met His Gly Tyr His Val Phe Asp 20 25 30 Asp His Arg
Val Asn Gly Ser Leu Asn Ile Ala Ala Gly Asp Gly Ala 35 40 45 Tyr
Ile Tyr Asp Thr Ala Gly Asn Arg Tyr Leu Asp Ala Val Gly Gly 50 55
60 Met Trp Cys Thr Asn Ile Gly Leu Gly Arg Glu Glu Met Ala Arg Thr
65 70 75 80 Val Ala Glu Gln Thr Arg Leu Leu Ala Tyr Ser Asn Pro Phe
Cys Asp 85 90 95 Met Ala Asn Pro Arg Ala Ile Glu Leu Cys Arg Lys
Leu Ala Glu Leu 100 105 110 Ala Pro Gly Asp Leu Asp His Val Phe Leu
Thr Thr Gly Gly Ser Thr 115 120 125 Ala Val Asp Thr Ala Ile Arg Leu
Met His Tyr Tyr Gln Asn Cys Arg 130 135 140 Gly Lys Arg Ala Lys Lys
His Val Ile Thr Arg Ile Asn Ala Tyr His 145 150 155 160 Gly Ser Thr
Phe Leu Gly Met Ser Leu Gly Gly Lys Ser Ala Asp Arg 165 170 175 Pro
Ala Glu Phe Asp Phe Leu Asp Glu Arg Ile His His Leu Ala Cys 180 185
190 Pro Tyr Tyr Tyr Arg Ala Pro Glu Gly Leu Gly Glu Ala Glu Phe Leu
195 200 205 Asp Gly Leu Val Asp Glu Phe Glu Arg Lys Ile Leu Glu Leu
Gly Ala 210 215 220 Asp Arg Val Gly Ala Phe Ile Ser Glu Pro Val Phe
Gly Ser Gly Gly 225 230 235 240 Val Ile Val Pro Pro Ala Gly Tyr His
Arg Arg Met Trp Glu Leu Cys 245 250 255 Gln Arg Tyr Asp Val Leu Tyr
Ile Ser Asp Glu Val Val Thr Ser Phe 260 265 270 Gly Arg Leu Gly His
Phe Phe Ala Ser Gln Ala Val Phe Gly Val Gln 275 280 285 Pro Asp Ile
Ile Leu Thr Ala Lys Gly Leu Thr Ser Gly Tyr Gln Pro 290 295 300 Leu
Gly Ala Cys Ile Phe Ser Arg Arg Ile Trp Glu Val Ile Ala Glu 305 310
315 320 Pro Asp Lys Gly Arg Cys Phe Ser His Gly Phe Thr Tyr Ser Gly
His 325 330 335 Pro Val Ala Cys Ala Ala Ala Leu Lys Asn Ile Glu Ile
Ile Glu Arg 340 345 350 Glu Gly Leu Leu Ala His Ala Asp Glu Val Gly
Arg Tyr Phe Glu Glu 355 360 365 Arg Leu Gln Ser Leu Arg Asp Leu Pro
Ile Val Gly Asp Val Arg Gly 370 375 380 Met Arg Phe Met Ala Cys Val
Glu Phe Val Ala Asp Lys Ala Ser Lys 385 390 395 400 Ala Leu Phe Pro
Glu Ser Leu Asn Ile Gly Glu Trp Val His Leu Arg 405 410 415 Ala Gln
Lys Arg Gly Leu Leu Val Arg Pro Ile Val His Leu Asn Val 420 425 430
Met Ser Pro Pro Leu Ile Leu Thr
Arg Glu Gln Val Asp Thr Val Val 435 440 445 Arg Val Leu Arg Glu Ser
Ile Glu Glu Thr Val Glu Asp Leu Val Arg 450 455 460 Ala Gly His Arg
465 1371335DNAArtificialPseudomonas aeruginosa 137atgacaatga
atgacgagcc gcagtcgagc agcctcgaca acttctggat gcccttcacc 60gccaaccgcc
agttcaaggc gcggccgcgc ctgctggaaa gcgccgaagg catccactat
120atcgcccagg gcgggcgccg catcctcgac ggcaccgccg gcctctggtg
ctgcaatgcc 180ggccacggcc ggcgcgagat cagcgaagcg gtggcccggc
agatcgccac cctcgactac 240gccccgccgt tccagatggg tcacccgctg
ccgttcgaac tcgccgcgcg gctgacggaa 300atcgccccgc cgagcctgaa
caaagtattc ttcaccaact ccggctcgga atcggcggac 360accgcgctga
agatcgccct tgcctaccag cgcgccatcg gccagggcac ccgcacccgc
420ctgatcggcc gcgaactggg ctaccacggg gtcggcttcg gcggcctgtc
ggtaggcggt 480atggtcaaca accgcaaggc cttctccgcc aacctgctgc
cgggggtcga ccacctgccg 540cacaccctgg acgtcgcccg caacgccttc
accgtcggcc tgcccgagca tggcgtggaa 600aaggccgagg agctggaacg
cctggtgacc ctgcacggcg ccgagaatat cgccgcggtg 660atcgtcgagc
cgatgtccgg ctcggccggc gtggtgctgc cgcccaaggg ctaccttcag
720cggctgcgcg agataacccg caagcatggc atcctgctga tcttcgacga
agtgatcacc 780ggtttcggcc gcgtcggcga agccttcgcc gcgcagcgct
ggggcgtcgt cccggacctg 840ctgacctgcg ccaaggggct gaccaacggc
agcatcccga tgggcgccgt attcgtcgac 900gagaagatcc atgctgcctt
catgcaaggc ccgcagggcg ccatcgagtt cttccacggc 960tatacctatt
ccggccatcc ggtagcctgc gccgccgccc tggcgaccct ggacatctac
1020cgtcgcgacg acctgttcca gcgggccgtc gaactggaag gctactggca
ggacgcgctg 1080ttcagcctgc gcgacctgcc caacgtggtc gacatccgcg
ccgtaggcct ggtcggcggc 1140gtgcaactgg cgccgcacgc ggacggcccc
ggcaagcgcg gctacgacgt cttcgagcgc 1200tgcttctggg agcacgacct
gatggtccgg gtgaccggcg acatcatcgc catgtcgccg 1260ccgctgatca
tcgacaagcc ccacatcgac cagatcgtcg agcgcctggc ccaggccatc
1320cgcgccagcg tctga 1335138444PRTPseudomonas aeruginosa 138Met Thr
Met Asn Asp Glu Pro Gln Ser Ser Ser Leu Asp Asn Phe Trp 1 5 10 15
Met Pro Phe Thr Ala Asn Arg Gln Phe Lys Ala Arg Pro Arg Leu Leu 20
25 30 Glu Ser Ala Glu Gly Ile His Tyr Ile Ala Gln Gly Gly Arg Arg
Ile 35 40 45 Leu Asp Gly Thr Ala Gly Leu Trp Cys Cys Asn Ala Gly
His Gly Arg 50 55 60 Arg Glu Ile Ser Glu Ala Val Ala Arg Gln Ile
Ala Thr Leu Asp Tyr 65 70 75 80 Ala Pro Pro Phe Gln Met Gly His Pro
Leu Pro Phe Glu Leu Ala Ala 85 90 95 Arg Leu Thr Glu Ile Ala Pro
Pro Ser Leu Asn Lys Val Phe Phe Thr 100 105 110 Asn Ser Gly Ser Glu
Ser Ala Asp Thr Ala Leu Lys Ile Ala Leu Ala 115 120 125 Tyr Gln Arg
Ala Ile Gly Gln Gly Thr Arg Thr Arg Leu Ile Gly Arg 130 135 140 Glu
Leu Gly Tyr His Gly Val Gly Phe Gly Gly Leu Ser Val Gly Gly 145 150
155 160 Met Val Asn Asn Arg Lys Ala Phe Ser Ala Asn Leu Leu Pro Gly
Val 165 170 175 Asp His Leu Pro His Thr Leu Asp Val Ala Arg Asn Ala
Phe Thr Val 180 185 190 Gly Leu Pro Glu His Gly Val Glu Lys Ala Glu
Glu Leu Glu Arg Leu 195 200 205 Val Thr Leu His Gly Ala Glu Asn Ile
Ala Ala Val Ile Val Glu Pro 210 215 220 Met Ser Gly Ser Ala Gly Val
Val Leu Pro Pro Lys Gly Tyr Leu Gln 225 230 235 240 Arg Leu Arg Glu
Ile Thr Arg Lys His Gly Ile Leu Leu Ile Phe Asp 245 250 255 Glu Val
Ile Thr Gly Phe Gly Arg Val Gly Glu Ala Phe Ala Ala Gln 260 265 270
Arg Trp Gly Val Val Pro Asp Leu Leu Thr Cys Ala Lys Gly Leu Thr 275
280 285 Asn Gly Ser Ile Pro Met Gly Ala Val Phe Val Asp Glu Lys Ile
His 290 295 300 Ala Ala Phe Met Gln Gly Pro Gln Gly Ala Ile Glu Phe
Phe His Gly 305 310 315 320 Tyr Thr Tyr Ser Gly His Pro Val Ala Cys
Ala Ala Ala Leu Ala Thr 325 330 335 Leu Asp Ile Tyr Arg Arg Asp Asp
Leu Phe Gln Arg Ala Val Glu Leu 340 345 350 Glu Gly Tyr Trp Gln Asp
Ala Leu Phe Ser Leu Arg Asp Leu Pro Asn 355 360 365 Val Val Asp Ile
Arg Ala Val Gly Leu Val Gly Gly Val Gln Leu Ala 370 375 380 Pro His
Ala Asp Gly Pro Gly Lys Arg Gly Tyr Asp Val Phe Glu Arg 385 390 395
400 Cys Phe Trp Glu His Asp Leu Met Val Arg Val Thr Gly Asp Ile Ile
405 410 415 Ala Met Ser Pro Pro Leu Ile Ile Asp Lys Pro His Ile Asp
Gln Ile 420 425 430 Val Glu Arg Leu Ala Gln Ala Ile Arg Ala Ser Val
435 440 139467PRTEscherichia coli 139Met Asn Gln Gln Asp Ile Glu
Gln Val Val Lys Ala Val Leu Leu Lys 1 5 10 15 Met Gln Ser Ser Asp
Thr Pro Ser Ala Ala Val His Glu Met Gly Val 20 25 30 Phe Ala Ser
Leu Asp Asp Ala Val Ala Ala Ala Lys Val Ala Gln Gln 35 40 45 Gly
Leu Lys Ser Val Ala Met Arg Gln Leu Ala Ile Ala Ala Ile Arg 50 55
60 Glu Ala Gly Glu Lys His Ala Arg Asp Leu Ala Glu Leu Ala Val Ser
65 70 75 80 Glu Thr Gly Met Gly Arg Val Glu Asp Lys Phe Ala Lys Asn
Val Ala 85 90 95 Gln Ala Arg Gly Thr Pro Gly Val Glu Cys Leu Ser
Pro Gln Val Leu 100 105 110 Thr Gly Asp Asn Gly Leu Thr Leu Ile Glu
Asn Ala Pro Trp Gly Val 115 120 125 Val Ala Ser Val Thr Pro Ser Thr
Asn Pro Ala Ala Thr Val Ile Asn 130 135 140 Asn Ala Ile Ser Leu Ile
Ala Ala Gly Asn Ser Val Ile Phe Ala Pro 145 150 155 160 His Pro Ala
Ala Lys Lys Val Ser Gln Arg Ala Ile Thr Leu Leu Asn 165 170 175 Gln
Ala Ile Val Ala Ala Gly Gly Pro Glu Asn Leu Leu Val Thr Val 180 185
190 Ala Asn Pro Asp Ile Glu Thr Ala Gln Arg Leu Phe Lys Phe Pro Gly
195 200 205 Ile Gly Leu Leu Val Val Thr Gly Gly Glu Ala Val Val Glu
Ala Ala 210 215 220 Arg Lys His Thr Asn Lys Arg Leu Ile Ala Ala Gly
Ala Gly Asn Pro 225 230 235 240 Pro Val Val Val Asp Glu Thr Ala Asp
Leu Ala Arg Ala Ala Gln Ser 245 250 255 Ile Val Lys Gly Ala Ser Phe
Asp Asn Asn Ile Ile Cys Ala Asp Glu 260 265 270 Lys Val Leu Ile Val
Val Asp Ser Val Ala Asp Glu Leu Met Arg Leu 275 280 285 Met Glu Gly
Gln His Ala Val Lys Leu Thr Ala Glu Gln Ala Gln Gln 290 295 300 Leu
Gln Pro Val Leu Leu Lys Asn Ile Asp Glu Arg Gly Lys Gly Thr 305 310
315 320 Val Ser Arg Asp Trp Val Gly Arg Asp Ala Gly Lys Ile Ala Ala
Ala 325 330 335 Ile Gly Leu Lys Val Pro Gln Glu Thr Arg Leu Leu Phe
Val Glu Thr 340 345 350 Thr Ala Glu His Pro Phe Ala Val Thr Glu Leu
Met Met Pro Val Leu 355 360 365 Pro Val Val Arg Val Ala Asn Val Ala
Asp Ala Ile Ala Leu Ala Val 370 375 380 Lys Leu Glu Gly Gly Cys His
His Thr Ala Ala Met His Ser Arg Asn 385 390 395 400 Ile Glu Asn Met
Asn Gln Met Ala Asn Ala Ile Asp Thr Ser Ile Phe 405 410 415 Val Lys
Asn Gly Pro Cys Ile Ala Gly Leu Gly Leu Gly Gly Glu Gly 420 425 430
Trp Thr Thr Met Thr Ile Thr Thr Pro Thr Gly Glu Gly Val Thr Ser 435
440 445 Ala Arg Thr Phe Val Arg Leu Arg Arg Cys Val Leu Val Asp Ala
Phe 450 455 460 Arg Ile Val 465 140532PRTClostridium tetani 140Met
Glu Lys Tyr Asp Lys Asp Leu Tyr Ser Ile Gln Gln Ala Arg Asn 1 5 10
15 Leu Ala Arg Leu Gly Lys Val Ala Ala Asn Lys Ile Ala Asn Tyr Thr
20 25 30 Glu Glu Gln Ile Asp Lys Ile Leu Arg Asn Met Val Arg Val
Ala Glu 35 40 45 Glu Asn Ala Val Ser Leu Ala Gln Met Ala Val Glu
Glu Thr Gly Phe 50 55 60 Gly Lys Val Glu Asp Lys Thr Tyr Lys Asn
His Leu Ala Ala Thr Ile 65 70 75 80 Leu Tyr Asp Ser Ile Lys Asp Met
Lys Thr Ile Gly Val Ile Ser Glu 85 90 95 Asp Lys Val Asn Lys Met
Ile Glu Ile Ala Glu Pro Val Gly Leu Ile 100 105 110 Met Gly Ile Val
Pro Ser Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys 115 120 125 Ser Ile
Ile Ala Ile Lys Ser Arg Asn Ala Ile Val Phe Ser Pro His 130 135 140
Pro Ala Ala Ala Lys Cys Thr Ile Arg Ala Val Glu Leu Met Arg Asp 145
150 155 160 Ala Ala Ile Glu Ala Gly Ala Pro Glu Asp Ile Ile Ala Ser
Leu Thr 165 170 175 Asn Leu Thr Met Glu Ala Thr Asn Glu Leu Met Lys
Asn Glu Asn Val 180 185 190 Ser Leu Ile Ile Ala Thr Gly Gly Pro Gly
Met Val Lys Ala Ala Tyr 195 200 205 Ser Ser Gly Lys Pro Ala Ile Gly
Val Gly Ala Gly Asn Ser Pro Ala 210 215 220 Tyr Ile Glu Arg Thr Ala
Asn Val Glu Lys Ala Ile Arg Asp Ile Ile 225 230 235 240 Ser Ser Lys
Ser Phe Asp Tyr Gly Thr Ile Cys Ala Ser Glu Gln Ser 245 250 255 Ile
Ile Cys Glu Glu Cys Asn His Asp Ala Val Val Glu Glu Leu Lys 260 265
270 Lys Gln Gly Gly Tyr Phe Met Thr Ala Glu Glu Thr Glu Lys Val Cys
275 280 285 Lys Leu Leu Phe Lys Asn Gly His Thr Met Asn Ala Lys Phe
Val Gly 290 295 300 Arg Ser Pro Gln Val Ile Ala Asn Ala Ala Gly Phe
Thr Val Ser Glu 305 310 315 320 Asp Ile Lys Val Leu Ile Gly Lys Gln
Asn Gly Val Gly Asn Gly Asn 325 330 335 Pro Leu Ser Phe Glu Lys Leu
Thr Thr Val Leu Ala Phe Tyr Thr Val 340 345 350 Lys Asp Trp His Glu
Ala Cys Glu Leu Ser Ile Glu Leu Leu Gln Asn 355 360 365 Gly Ile Gly
His Thr Met Ser Ile His Thr Gln Asn Asp Asp Ile Val 370 375 380 Met
Glu Phe Ala Lys Lys Pro Ala Ser Arg Ile Leu Val Asn Thr Gly 385 390
395 400 Gly Ser Gln Gly Gly Thr Gly Ala Ser Thr Gly Leu Lys Pro Ala
Phe 405 410 415 Thr Leu Gly Cys Gly Thr Trp Gly Gly Ser Ser Val Ser
Glu Asn Val 420 425 430 Thr Pro Glu His Leu Ile Asn Lys Lys Arg Val
Ala Tyr Gly Leu Lys 435 440 445 Asp Cys Ala Thr Leu Val Gln Asn Asp
Pro Thr Phe Asn Cys Ile Lys 450 455 460 Thr Ala Ser Asn Cys Arg Gly
Val Lys Asn Gln Phe Met Asn Met Ser 465 470 475 480 Pro Ala Gln Ile
Ala Ala Ala Ala Glu Val Leu Asn Lys Cys Asn Asp 485 490 495 Tyr Ala
Lys Asn Thr Gly Cys Ser Asn Glu Ser Lys Glu Lys Asp Ala 500 505 510
Asn Asn Glu Glu Leu Leu Ser Leu Val Asn Gln Ile Val Ala Ala Met 515
520 525 Lys Gly Ala Asn 530 141297PRTBurkholderia thailandensis
141Met Lys Asn Lys Ser Ser Arg Thr Arg Val Ala Ile Leu Gly Ser Gly
1 5 10 15 Ser Ile Gly Leu Asp Leu Met Phe Lys Val Lys Ala Ser Glu
His Phe 20 25 30 Asp Leu Lys Phe Val Val Gly Arg His Ala Asn Ser
Asp Gly Leu Lys 35 40 45 Leu Ala Arg Ser Cys Asn Val Glu Thr Ser
Ser Asp Gly Leu Asp Phe 50 55 60 Leu Lys Glu Asn Glu Asp Ala Tyr
Asp Leu Val Phe Asp Ala Thr Ser 65 70 75 80 Ala Ala Ala His Lys Val
Asn Asn Gly Phe Phe Ser Gly Ala Gly Lys 85 90 95 Phe Val Ile Asp
Leu Thr Pro Ala Lys Leu Gly Arg Leu Cys Val Pro 100 105 110 Cys Ile
Asn Leu Asp Asp Ile Gly Ala Glu Gln Asn Val Asn Leu Ile 115 120 125
Thr Cys Gly Gly Gln Ala Ser Leu Pro Leu Ala Tyr Ala Leu Lys Gln 130
135 140 Ala Val Asp Glu Ile Glu Tyr Leu Glu Val Val Ser Ala Ile Ala
Ser 145 150 155 160 Arg Ser Ala Gly Ile Ala Thr Arg Glu Asn Ile Asp
Glu Tyr Met Thr 165 170 175 Thr Thr Glu Tyr Ala Leu Ala Gln Phe Ser
Gly Ala Lys Lys Thr Lys 180 185 190 Ala Ile Leu Asn Ile Asn Pro Ala
Glu Pro Gly Val Arg Met Gln Thr 195 200 205 Thr Leu Tyr Ala His Ala
Arg Tyr Arg Asp Phe Asp Arg Val Arg Ala 210 215 220 Cys Val Ala Glu
Met Val Glu Lys Val Arg Glu Tyr Val Pro Gly Tyr 225 230 235 240 Arg
Leu Val Val Glu Pro Ile Glu Ser Gln Gly Arg Ile Thr Ile Ser 245 250
255 Leu Thr Val Arg Gly Arg Gly Asp Tyr Leu Pro Glu Tyr Ala Gly Asn
260 265 270 Leu Asp Ile Ile Asn Cys Ala Ala Leu Ala Val Ala Ser His
Arg His 275 280 285 Ala Thr Ala Arg Leu Gly Ala Thr Gln 290 295
142316PRTPseudomonas putida 142Met Thr Arg Lys Val Lys Ala Ala Ile
Ile Gly Ser Gly Asn Ile Gly 1 5 10 15 Thr Asp Leu Met Ile Lys Ile
Leu Arg His Gly Gln His Ile Glu Met 20 25 30 Gly Ala Met Val Gly
Ile Asp Pro Ala Ser Asp Gly Leu Ala Arg Ala 35 40 45 Gln Arg Met
Gly Val Ala Ile Thr His Glu Gly Val Glu Gly Leu Thr 50 55 60 Arg
Leu Pro Val Phe Asn Glu Ile Asp Val Val Phe Asp Ala Thr Ser 65 70
75 80 Ala Gly Ala His Val Lys Asn Glu Ala Leu Leu Arg Glu Arg Lys
Pro 85 90 95 Gly Leu Arg Met Ile Asp Leu Thr Pro Ala Ala Ile Gly
Pro Tyr Cys 100 105 110 Ile Pro Val Val Asn Gly Asp Asp His Leu Asp
Ala Thr Asn Val Asn 115 120 125 Met Val Thr Cys Gly Gly Gln Ala Thr
Ile Pro Met Val Ala Ala Val 130 135 140 Ser Arg Val Ala Lys Val His
Tyr Ala Glu Ile Ile Ala Ser Ile Ser 145 150 155 160 Ser Lys Ser Ala
Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr 165 170 175 Glu Thr
Thr Ser Lys Ala Ile Glu Val Val Gly Gly Ala Ala Lys Gly 180 185 190
Lys Ala Ile Ile Val Leu Asn Pro Ala Glu Pro Pro Leu Met Met Arg 195
200 205 Asp Thr Val Tyr Thr Leu Ser Asp Phe Ala Asp Ile Asp Gln Ile
Glu 210 215 220 Glu Ser Val Gln Arg Met Ala Asp Ala Val Gln Ala Tyr
Val Pro Gly 225 230 235 240 Tyr Arg Leu Lys Gln Arg Val Gln Phe Asp
Arg Ile Glu Ala Asp Cys 245 250 255 Pro Ile Arg Ile Pro Gly Val Gly
Asp Arg Met Asn Gly Leu Lys Thr 260 265 270 Ser Ile Phe Leu Glu Val
Glu Gly Ala Ala His Tyr Leu Pro Ala Tyr 275 280 285 Ala Gly Asn Leu
Asp Ile Met Thr Ser Ala Ala Leu Arg Thr Ala Glu 290
295 300 Lys Leu Ala Glu Arg Leu Leu Ala Ser Leu Val Ala 305 310 315
143539PRTBurkholderia mallei 143Met His Arg Gly Ala Ala Cys Trp His
Gly Phe Gly Val Thr Asn Gly 1 5 10 15 Val Ala His Val Ala Arg Arg
Ile Thr Asp Thr Asp Met Arg Gly Ala 20 25 30 Thr Met Asn His Ala
Asp Met Gln His Leu Asn Ile Glu Phe Pro Tyr 35 40 45 Arg Lys Gln
Tyr Gly Asn Phe Ile Gly Gly Glu Trp Val Ala Pro Val 50 55 60 Gly
Gly Glu Tyr Phe Asp Asn Val Ser Pro Val Thr Gly Arg Pro Phe 65 70
75 80 Thr Ala Ile Pro Arg Ser Arg Glu Ala Asp Ile Glu Leu Ala Leu
Asp 85 90 95 Ala Ala His Ala Ala Lys Ala Gly Trp Ala Ala Lys Gly
Ala Ala Glu 100 105 110 Arg Ala Asn Val Leu Leu Arg Ile Ala Asp Arg
Met Glu Ala Asn Leu 115 120 125 Thr Arg Leu Ala Val Ala Glu Thr Ile
Asp Asn Gly Lys Pro Leu Arg 130 135 140 Glu Thr Thr Ala Ala Asp Val
Pro Leu Ala Ile Asp His Phe Arg Tyr 145 150 155 160 Phe Ala Gly Cys
Ile Arg Ala Gln Glu Gly Ser Ile Ala Asp Ile Gly 165 170 175 Gly Asp
Met Val Ala Tyr His Phe His Glu Pro Leu Gly Val Val Gly 180 185 190
Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Ala Ala Trp Lys Leu 195
200 205 Ala Pro Ala Leu Ala Ala Gly Asn Cys Val Val Leu Lys Pro Ala
Glu 210 215 220 Gln Thr Pro Ala Ser Ile Leu Val Phe Ala Glu Leu Ile
Gln Asp Leu 225 230 235 240 Leu Pro Pro Gly Val Leu Asn Ile Val Asn
Gly Phe Gly Leu Glu Ala 245 250 255 Gly Lys Pro Leu Ala Ser Ser Lys
Arg Ile Ala Lys Ile Ala Phe Thr 260 265 270 Gly Glu Thr Ser Thr Gly
Arg Leu Ile Met Gln Tyr Ala Ser Glu Asn 275 280 285 Leu Ile Pro Val
Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile Phe 290 295 300 Phe Ala
Asp Val Met Asp Arg Asp Asp Ser Tyr Phe Asp Lys Ala Leu 305 310 315
320 Glu Gly Phe Ala Met Phe Ala Leu Asn Gln Gly Glu Val Cys Thr Cys
325 330 335 Pro Ser Arg Ala Leu Val Glu Glu Ser Ile Tyr Asp Arg Phe
Ile Glu 340 345 350 Arg Ala Leu Lys Arg Val Glu Ala Ile Lys Gln Gly
His Pro Leu Asp 355 360 365 Ser Gln Thr Met Ile Gly Ala Gln Ala Ser
Ala Glu Gln Leu Glu Lys 370 375 380 Ile Leu Ser Tyr Ile Asp Ile Gly
Arg Gly Glu Gly Ala Gln Cys Leu 385 390 395 400 Thr Gly Gly Glu Arg
Asn Val Leu Gly Gly Glu Leu Ala Glu Gly Tyr 405 410 415 Tyr Val Lys
Pro Thr Val Phe Arg Gly His Asn Lys Met Arg Ile Phe 420 425 430 Gln
Glu Glu Ile Phe Gly Pro Val Leu Ala Val Thr Thr Phe Lys Thr 435 440
445 Glu Glu Glu Ala Leu Glu Ile Ala Asn Asp Thr Leu Tyr Gly Leu Gly
450 455 460 Ala Gly Val Trp Thr Arg Asp Gly Asn Arg Ala Tyr Arg Phe
Gly Arg 465 470 475 480 Gly Ile Gln Ala Gly Arg Val Trp Thr Asn Cys
Tyr His Ala Tyr Pro 485 490 495 Ala His Ala Ala Phe Gly Gly Tyr Lys
Gln Ser Gly Ile Gly Arg Glu 500 505 510 Thr His Lys Met Met Leu Asp
His Tyr Gln Gln Thr Lys Asn Leu Leu 515 520 525 Val Ser Tyr Ser Glu
Lys Pro Leu Gly Phe Phe 530 535 144464PRTSalmonella typhimurium
144Met Asn Thr Ser Glu Leu Glu Thr Leu Ile Arg Thr Ile Leu Ser Glu
1 5 10 15 Gln Leu Thr Thr Pro Ala Gln Thr Pro Val Gln Pro Gln Gly
Lys Gly 20 25 30 Ile Phe Gln Ser Val Ser Glu Ala Ile Asp Ala Ala
His Gln Ala Phe 35 40 45 Leu Arg Tyr Gln Gln Cys Pro Leu Lys Thr
Arg Ser Ala Ile Ile Ser 50 55 60 Ala Met Arg Gln Glu Leu Thr Pro
Leu Leu Ala Pro Leu Ala Glu Glu 65 70 75 80 Ser Ala Asn Glu Thr Gly
Met Gly Asn Lys Glu Asp Lys Phe Leu Lys 85 90 95 Asn Lys Ala Ala
Leu Asp Asn Thr Pro Gly Val Glu Asp Leu Thr Thr 100 105 110 Thr Ala
Leu Thr Gly Asp Gly Gly Met Val Leu Phe Glu Tyr Ser Pro 115 120 125
Phe Gly Val Ile Gly Ser Val Ala Pro Ser Thr Asn Pro Thr Glu Thr 130
135 140 Ile Ile Asn Asn Ser Ile Ser Met Leu Ala Ala Gly Asn Ser Ile
Tyr 145 150 155 160 Phe Ser Pro His Pro Gly Ala Lys Lys Val Ser Leu
Lys Leu Ile Ser 165 170 175 Leu Ile Glu Glu Ile Ala Phe Arg Cys Cys
Gly Ile Arg Asn Leu Val 180 185 190 Val Thr Val Ala Glu Pro Thr Phe
Glu Ala Thr Gln Gln Met Met Ala 195 200 205 His Pro Arg Ile Ala Val
Leu Ala Ile Thr Gly Gly Pro Gly Ile Val 210 215 220 Ala Met Gly Met
Lys Ser Gly Lys Lys Val Ile Gly Ala Gly Ala Gly 225 230 235 240 Asn
Pro Pro Cys Ile Val Asp Glu Thr Ala Asp Leu Val Lys Ala Ala 245 250
255 Glu Asp Ile Ile Asn Gly Ala Ser Phe Asp Tyr Asn Leu Pro Cys Ile
260 265 270 Ala Glu Lys Ser Leu Ile Val Val Glu Ser Val Ala Glu Arg
Leu Val 275 280 285 Gln Gln Met Gln Thr Phe Gly Ala Leu Leu Leu Ser
Pro Ala Asp Thr 290 295 300 Asp Lys Leu Arg Ala Val Cys Leu Pro Glu
Gly Gln Ala Asn Lys Lys 305 310 315 320 Leu Val Gly Lys Ser Pro Ser
Ala Met Leu Glu Ala Ala Gly Ile Ala 325 330 335 Val Pro Ala Lys Ala
Pro Arg Leu Leu Ile Ala Leu Val Asn Ala Asp 340 345 350 Asp Pro Trp
Val Thr Ser Glu Gln Leu Met Pro Met Leu Pro Val Val 355 360 365 Lys
Val Ser Asp Phe Asp Ser Ala Leu Ala Leu Ala Leu Lys Val Glu 370 375
380 Glu Gly Leu His His Thr Ala Ile Met His Ser Gln Asn Val Ser Arg
385 390 395 400 Leu Asn Leu Ala Ala Arg Thr Leu Gln Thr Ser Ile Phe
Val Lys Asn 405 410 415 Gly Pro Ser Tyr Ala Gly Ile Gly Val Gly Gly
Glu Gly Phe Thr Thr 420 425 430 Phe Thr Ile Ala Thr Pro Thr Gly Glu
Gly Thr Thr Ser Ala Arg Thr 435 440 445 Phe Ala Arg Ser Arg Arg Cys
Val Leu Thr Asn Gly Phe Ser Ile Arg 450 455 460
145315PRTRhodococcus sp. 145Met Ser Thr Thr Lys Val Ala Val Ile Gly
Ser Gly Asn Ile Gly Thr 1 5 10 15 Asp Leu Val Ile Lys Leu Glu Gln
Val Ala Lys Asn Val Glu Ile Ala 20 25 30 Val Leu Val Gly Ile Asp
Pro Ala Ser Asp Gly Leu Ala Arg Ala Arg 35 40 45 Arg Leu Gly Ile
Ser Thr Val Asp Thr Gly Val Gln Gly Leu Ile Glu 50 55 60 His Pro
Glu Phe Asp Asp Ile Glu Ile Ile Phe Asp Ser Thr Ser Ala 65 70 75 80
Lys Ala His Leu Thr Asn Ala Glu Ala Leu Arg Pro Tyr Gly Lys His 85
90 95 Leu Ile Asp Leu Thr Pro Ala Ala Ile Gly Pro Tyr Val Val Pro
Ala 100 105 110 Val Asn Leu Asp Gln His Leu Gly Ala Pro Asp Val Asn
Met Val Thr 115 120 125 Cys Gly Gly Gln Ala Thr Ile Pro Ile Val Ala
Ala Ile Ser Lys Val 130 135 140 Thr Asp Val His Tyr Ala Glu Ile Val
Ala Ser Ile Ala Ser Lys Ser 145 150 155 160 Ala Gly Pro Gly Thr Arg
Ala Asn Ile Asp Glu Phe Thr Glu Thr Thr 165 170 175 Ala Lys Ala Ile
Glu Glu Val Gly Gly Ala Ala His Gly Lys Ala Ile 180 185 190 Ile Val
Leu Asn Pro Ala Asp Pro Pro Leu Ile Met Arg Asp Thr Val 195 200 205
Leu Ala Leu Val Ser Asn Pro Asp Gln Asp Ala Ile Arg Gln Ser Ile 210
215 220 Thr Asp Met Val Ala Thr Val Ala Ala Tyr Val Pro Gly Tyr Arg
Leu 225 230 235 240 Lys Gln Asp Val Gln Phe Thr Glu Leu Gly Gly Ala
Asp Thr Val Ala 245 250 255 Thr Leu Thr Gly Gly Ala Asp Ile Gly Ser
Pro Val Trp Lys Val Ser 260 265 270 Val Phe Leu Glu Val Glu Gly Ala
Ala His Tyr Leu Pro Ala Tyr Ala 275 280 285 Gly Asn Leu Asp Ile Met
Thr Ser Ala Ala Leu Gln Val Ala Glu Lys 290 295 300 Leu Ala Glu Arg
Thr Ala Leu Glu Ile Ala Arg 305 310 315 146468PRTClostridium
beijerinckii 146Met Asn Lys Asp Thr Leu Ile Pro Thr Thr Lys Asp Leu
Lys Leu Lys 1 5 10 15 Thr Asn Val Glu Asn Ile Asn Leu Lys Asn Tyr
Lys Asp Asn Ser Ser 20 25 30 Cys Phe Gly Val Phe Glu Asn Val Glu
Asn Ala Ile Asn Ser Ala Val 35 40 45 His Ala Gln Lys Ile Leu Ser
Leu His Tyr Thr Lys Glu Gln Arg Glu 50 55 60 Lys Ile Ile Thr Glu
Ile Arg Lys Ala Ala Leu Glu Asn Lys Glu Val 65 70 75 80 Leu Ala Thr
Met Ile Leu Glu Glu Thr His Met Gly Arg Tyr Glu Asp 85 90 95 Lys
Ile Leu Lys His Glu Leu Val Ala Lys Tyr Thr Pro Gly Thr Glu 100 105
110 Asp Leu Thr Thr Thr Ala Trp Ser Gly Asp Asn Gly Leu Thr Val Val
115 120 125 Glu Met Ser Pro Tyr Gly Val Ile Gly Ala Ile Thr Pro Ser
Thr Asn 130 135 140 Pro Thr Glu Thr Val Ile Cys Asn Ser Ile Gly Met
Ile Ala Ala Gly 145 150 155 160 Asn Ala Val Val Phe Asn Gly His Pro
Gly Ala Lys Lys Cys Val Ala 165 170 175 Phe Ala Ile Glu Met Ile Asn
Lys Ala Ile Ile Ser Cys Gly Gly Pro 180 185 190 Glu Asn Leu Val Thr
Thr Ile Lys Asn Pro Thr Met Glu Ser Leu Asp 195 200 205 Ala Ile Ile
Lys His Pro Leu Ile Lys Leu Leu Cys Gly Thr Gly Gly 210 215 220 Pro
Gly Met Val Lys Thr Leu Leu Asn Ser Gly Lys Lys Ala Ile Gly 225 230
235 240 Ala Gly Ala Gly Asn Pro Pro Val Ile Val Asp Asp Thr Ala Asp
Ile 245 250 255 Glu Lys Ala Gly Lys Ser Ile Ile Glu Gly Cys Ser Phe
Asp Asn Asn 260 265 270 Leu Pro Cys Ile Ala Glu Lys Glu Val Phe Val
Phe Glu Asn Val Ala 275 280 285 Asp Asp Leu Ile Ser Asn Met Leu Lys
Asn Asn Ala Val Ile Ile Asn 290 295 300 Glu Asp Gln Val Ser Lys Leu
Ile Asp Leu Val Leu Gln Lys Asn Asn 305 310 315 320 Glu Thr Gln Glu
Tyr Phe Ile Asn Lys Lys Trp Val Gly Lys Asp Ala 325 330 335 Lys Leu
Phe Ser Asp Glu Ile Asp Val Glu Ser Pro Ser Asn Ile Lys 340 345 350
Cys Ile Val Cys Glu Val Asn Ala Asn His Pro Phe Val Met Thr Glu 355
360 365 Leu Met Met Pro Ile Leu Pro Ile Val Arg Val Lys Asp Ile Asp
Glu 370 375 380 Ala Val Lys Tyr Thr Lys Ile Ala Glu Gln Asn Arg Lys
His Ser Ala 385 390 395 400 Tyr Ile Tyr Ser Lys Asn Ile Asp Asn Leu
Asn Arg Phe Glu Arg Glu 405 410 415 Ile Asp Thr Thr Ile Phe Val Lys
Asn Ala Lys Ser Phe Ala Gly Val 420 425 430 Gly Tyr Glu Ala Glu Gly
Phe Thr Thr Phe Thr Ile Ala Gly Ser Thr 435 440 445 Gly Glu Gly Ile
Thr Ser Ala Arg Asn Phe Thr Arg Gln Arg Arg Cys 450 455 460 Val Leu
Ala Gly 465 147475PRTBacillus thuringiensis 147Met Thr Asn Lys Thr
Asp Glu Lys Glu Val Gln Ala Met Val Asn Val 1 5 10 15 Val Ile Lys
Asp Glu Asn Asp Val Gln Glu Val Val Asn Thr Leu Val 20 25 30 Glu
Asn Gly Lys Glu Ala Leu Lys Ala Leu Glu Ser Tyr Thr Gln Glu 35 40
45 Gln Val Asp His Ile Val His Glu Met Ala Leu Ser Gly Leu Asp Gln
50 55 60 His Met Pro Leu Ala Lys Met Ala Val Glu Glu Thr Gly Arg
Gly Val 65 70 75 80 Tyr Glu Asp Lys Cys Thr Lys Asn Ile Phe Ala Thr
Glu Tyr Ile Trp 85 90 95 His Ser Ile Lys Lys Asp Lys Thr Val Gly
Ile Ile His Glu Asp Pro 100 105 110 His Glu Glu Val Ile Glu Ile Ala
Glu Pro Val Gly Val Val Ala Gly 115 120 125 Val Thr Pro Val Thr Asn
Pro Thr Ser Thr Thr Met Phe Lys Ala Ile 130 135 140 Ile Ala Met Lys
Thr Arg Asn Pro Ile Ile Phe Ala Phe His Pro Ser 145 150 155 160 Ala
Gln Gln Cys Ser Val Ala Ala Ala Lys Ile Leu Arg Asp Ala Ala 165 170
175 Ile Arg Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile Glu Lys Pro
180 185 190 Ser Val Glu Ala Thr Lys Arg Leu Met Asn His Glu Gly Val
Ala Leu 195 200 205 Val Leu Ala Thr Gly Gly Ala Gly Met Val Lys Ser
Ala Tyr Ser Thr 210 215 220 Gly Lys Pro Ala Leu Gly Val Gly Pro Gly
Asn Val Pro Cys Tyr Leu 225 230 235 240 Glu Lys Ser Ala His Val Lys
Arg Ala Val Asn Asp Leu Ile Leu Ser 245 250 255 Lys Thr Phe Asp Asn
Gly Met Ile Cys Ala Ser Glu Gln Ala Ile Ile 260 265 270 Val Asp Lys
Glu Ile Tyr Asn Gly Val Lys Lys Glu Met Gln Asp Asn 275 280 285 Asn
Cys Tyr Phe Val Thr Glu Glu Glu Arg Ile Lys Leu Glu Lys Leu 290 295
300 Val Ile Asn Glu Asn Thr Cys Ala Val Asn Ser Asp Ile Val Gly Lys
305 310 315 320 Ser Ala His Tyr Ile Ala Ser Leu Val Ser Ile Lys Val
Pro Glu Asp 325 330 335 Thr Lys Ile Leu Val Ala Glu Ile Lys Gly Val
Gly Ala Glu Tyr Pro 340 345 350 Leu Ser Arg Glu Lys Leu Ser Pro Val
Leu Ala Cys Ile Lys Ala Asn 355 360 365 Ser Gln Glu Glu Gly Phe Lys
Tyr Cys Glu Glu Met Leu Asn Leu Gly 370 375 380 Gly Leu Gly His Ser
Ala Val Ile His Ser Thr Asn Lys Glu Val Gln 385 390 395 400 Lys Gln
Phe Gly Leu Arg Met Lys Ala Cys Arg Leu Ile Val Asn Ser 405 410 415
Pro Ser Ala Gln Gly Gly Ile Gly Asp Ile Tyr Asn Ala Phe Ile Pro 420
425 430 Ser Leu Thr Leu Gly Cys Gly Ser Tyr Gly Lys Asn Ser Val Ser
Gln 435 440 445 Asn Val Thr Ala Thr His Ile Ile Asn Val Lys Arg Leu
Ala Asn Ser 450 455 460 Pro Asp Asn Met Arg Gly Phe Thr Ile Thr Thr
465 470 475 148467PRTunknownunclassified
gamma proteobacterium protein 148Met Ser Glu Ala Gln Ser Pro Ala
Gln Glu Val Ala Glu Met Met Ser 1 5 10 15 Arg Ala Arg Ala Ala Gln
Ala Gln Ile Ala Asp Tyr Thr Gln Glu Gln 20 25 30 Val Asp Glu Leu
Ile Thr Ala Met Val Tyr Ala Val Ala Arg Glu Asp 35 40 45 Arg Ser
Glu Glu Ile Ala Arg Phe Thr Val Glu Glu Thr Gln Leu Gly 50 55 60
Asn Tyr Glu Gly Lys Tyr Leu Lys Ile His Arg Lys Thr Arg Ala Thr 65
70 75 80 Leu Met Asp Ile Ile Asp Asp Lys Ser Val Gly Val Ile Glu
Glu Leu 85 90 95 Pro Glu Arg Asn Ile Val Lys Ile Ala Lys Pro Val
Gly Val Ile Gly 100 105 110 Ala Leu Ser Pro Ser Thr Asn Pro Glu Ala
Thr Pro Val Ile Lys Ala 115 120 125 Ile Ser Ala Val Lys Gly Arg Asn
Ala Ile Ile Val Ala Pro His Pro 130 135 140 Arg Ala Lys Leu Thr Asn
Lys Lys Ile Cys Asp Tyr Met Arg Glu Ala 145 150 155 160 Leu Glu Leu
Cys Gly Ala Pro Ala Asp Leu Val Gln Ser Ile Asp Val 165 170 175 Pro
Ser Leu Asp Lys Thr Asn Glu Leu Met Ala Gln Cys Asp Arg Val 180 185
190 Leu Ala Thr Gly Gly Glu Ala Met Val Thr Ala Ala Tyr Ser Ser Gly
195 200 205 Thr Pro Ala Leu Gly Val Gly Val Gly Asn Ala Val Ile Thr
Val Asp 210 215 220 Asp Thr Ala Asp Leu Asp Glu Ala Ala Glu Lys Ile
Arg Ile Ser Lys 225 230 235 240 Thr Leu Asp Leu Ala Ala Ser Cys Ser
Ser Asp Asn Ser Val Leu Val 245 250 255 Phe Glu Ser Val Tyr Asn Glu
Leu Leu Glu Lys Leu Lys His Glu Gly 260 265 270 Gly Phe Val Ile Glu
Gly Asp Asp Lys Ala Lys Leu Gln Ser Val Ile 275 280 285 Trp Glu Asp
Asp His Leu Asn Ala Lys Ile Val Ala Gln His Ala Gln 290 295 300 Thr
Ile Cys Gly Gln Ala Gly Ile Asp Leu Pro Glu Gly Lys Ser Phe 305 310
315 320 Leu Ile Val Pro Glu Thr Gly Ala Gly Ala Asp His Pro Phe Ser
Gly 325 330 335 Glu Lys Leu Thr Val Thr Met Ala Leu Tyr Lys Val Lys
Asp Ile Asp 340 345 350 Glu Ala Ile Glu Met Thr Asn Lys Ile Gln Ala
Tyr Gln Gly Gln Gly 355 360 365 His Ser Cys Gly Ile Tyr Ser Tyr Asn
Asp Asp Asn Val Leu Lys Leu 370 375 380 Ala Asp Ala Thr Arg Thr Ser
Arg Val Met Val Asn Gln Pro Gln Ala 385 390 395 400 Ala Ser Asn Ser
Gly Asn Leu Trp Asn Gly Met Arg Gln Thr Phe Ser 405 410 415 Leu Gly
Cys Gly Ser Trp Gly Gly Asn Ser Ile Asn His Asn Ile Thr 420 425 430
Trp Arg Asp Leu Ile Asn Glu Thr Trp Val Ser Lys Pro Leu Ala Thr 435
440 445 Thr Lys Thr Ile Pro Ser Asp Glu Glu Leu Phe Gly Ala Val Met
Ala 450 455 460 Lys Phe Ser 465
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