U.S. patent application number 14/111837 was filed with the patent office on 2014-05-15 for beta-2 microglobulin-deficient cells. This patent application is currently assigned to University of Washington through its Center for Commercialization. The applicant listed for this patent is David W. Russell. Invention is credited to David W. Russell.
Application Number | 20140134195 14/111837 |
Document ID | / |
Family ID | 46051930 |
Filed Date | 2014-05-15 |
United States Patent Application | 20140134195 |
Kind Code | A1 |
Russell; David W. | May 15, 2014 |
The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.
Inventors: | Russell; David W.; (Seattle, WA) | ||||||||||
Applicant: |
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Assignee: | University of Washington through
its Center for Commercialization Seattle WA |
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Family ID: | 46051930 | ||||||||||
Appl. No.: | 14/111837 | ||||||||||
Filed: | April 18, 2012 | ||||||||||
PCT Filed: | April 18, 2012 | ||||||||||
PCT NO: | PCT/US12/34051 | ||||||||||
371 Date: | December 18, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
61477474 | Apr 20, 2011 | |||
Current U.S. Class: | 424/184.1 ; 424/93.21; 435/363; 435/366 |
Current CPC Class: | A61K 39/0005 20130101; C07K 2319/00 20130101; C12N 2740/17043 20130101; A61K 35/28 20130101; A61P 17/02 20180101; A61P 37/06 20180101; A61K 35/12 20130101; A61P 7/06 20180101; C12N 2800/30 20130101; A61P 19/02 20180101; A61P 37/02 20180101; A61P 19/00 20180101; A61P 9/04 20180101; A61K 2039/515 20130101; A61P 7/00 20180101; A61P 31/00 20180101; C12N 2750/14143 20130101; A61P 3/10 20180101; C07K 14/70539 20130101 |
Class at Publication: | 424/184.1 ; 435/363; 435/366; 424/93.21 |
International Class: | A61K 39/00 20060101 A61K039/00; A61K 35/28 20060101 A61K035/28 |
Sequence CWU 1
1
231987DNAHomo sapiensCDS(61)..(420) 1aatataagtg gaggcgtcgc
gctggcgggc attcctgaag ctgacagcat tcgggccgag 60atg tct cgc tcc gtg
gcc tta gct gtg ctc gcg cta ctc tct ctt tct 108Met Ser Arg Ser Val
Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser1 5 10 15 ggc ctg gag
gct atc cag cgt act cca aag att cag gtt tac tca cgt 156Gly Leu Glu
Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 20 25 30cat cca
gca gag aat gga aag tca aat ttc ctg aat tgc tat gtg tct 204His Pro
Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 35 40 45ggg
ttt cat cca tcc gac att gaa gtt gac tta ctg aag aat gga gag 252Gly
Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 50 55
60aga att gaa aaa gtg gag cat tca gac ttg tct ttc agc aag gac tgg
300Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp
Trp65 70 75 80tct ttc tat ctc ttg tac tac act gaa ttc acc ccc act
gaa aaa gat 348Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr
Glu Lys Asp 85 90 95gag tat gcc tgc cgt gtg aac cat gtg act ttg tca
cag ccc aag ata 396Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser
Gln Pro Lys Ile 100 105 110gtt aag tgg gat cga gac atg taa
gcagcatcat ggaggtttga agatgccgca 450Val Lys Trp Asp Arg Asp Met
115tttggattgg atgaattcca aattctgctt gcttgctttt taatattgat
atgcttatac 510acttacactt tatgcacaaa atgtagggtt ataataatgt
taacatggac atgatcttct 570ttataattct actttgagtg ctgtctccat
gtttgatgta tctgagcagg ttgctccaca 630ggtagctcta ggagggctgg
caacttagag gtggggagca gagaattctc ttatccaaca 690tcaacatctt
ggtcagattt gaactcttca atctcttgca ctcaaagctt gttaagatag
750ttaagcgtgc ataagttaac ttccaattta catactctgc ttagaatttg
ggggaaaatt 810tagaaatata attgacagga ttattggaaa tttgttataa
tgaatgaaac attttgtcat 870ataagattca tatttacttc ttatacattt
gataaagtaa ggcatggttg tggttaatct 930ggtttatttt tgttccacaa
gttaaataaa tcataaaact tgatgtgtta tctctta 9872119PRTHomo sapiens
2Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 1
5 10 15 Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser
Arg 20 25 30 His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys
Tyr Val Ser 35 40 45 Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu
Leu Lys Asn Gly Glu 50 55 60 Arg Ile Glu Lys Val Glu His Ser Asp
Leu Ser Phe Ser Lys Asp Trp 65 70 75 80 Ser Phe Tyr Leu Leu Tyr Tyr
Thr Glu Phe Thr Pro Thr Glu Lys Asp 85 90 95 Glu Tyr Ala Cys Arg
Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 100 105 110 Val Lys Trp
Asp Arg Asp Met 115 31611DNAHomo sapiensCDS(85)..(1182) 3gagaagccaa
tcagtgtcgt cgcggtcgct gttctaaagt ccgcacgcac ccaccgggac 60tcagattctc
cccagacgcc gagg atg gcc gtc atg gcg ccc cga acc ctc 111 Met Ala Val
Met Ala Pro Arg Thr Leu 1 5 ctc ctg cta ctc tcg ggg gcc ctg gcc ctg
acc cag acc tgg gcg ggc 159Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu
Thr Gln Thr Trp Ala Gly10 15 20 25tcc cac tcc atg agg tat ttc ttc
aca tcc gtg tcc cgg ccc ggc cgc 207Ser His Ser Met Arg Tyr Phe Phe
Thr Ser Val Ser Arg Pro Gly Arg 30 35 40ggg gag ccc cgc ttc atc gcc
gtg ggc tac gtg gac gac acg cag ttc 255Gly Glu Pro Arg Phe Ile Ala
Val Gly Tyr Val Asp Asp Thr Gln Phe 45 50 55gtg cgg ttc gac agc gac
gcc gcg agc cag aag atg gag ccg cgg gcg 303Val Arg Phe Asp Ser Asp
Ala Ala Ser Gln Lys Met Glu Pro Arg Ala 60 65 70ccg tgg ata gag cag
gag ggg ccg gag tat tgg gac cag gag aca cgg 351Pro Trp Ile Glu Gln
Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr Arg 75 80 85aat atg aag gcc
cac tca cag act gac cga gcg aac ctg ggg acc ctg 399Asn Met Lys Ala
His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr Leu90 95 100 105cgc ggc
tac tac aac cag agc gag gac ggt tct cac acc atc cag ata 447Arg Gly
Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln Ile 110 115
120atg tat ggc tgc gac gtg ggg ccg gac ggg cgc ttc ctc cgc ggg tac
495Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr
125 130 135cgg cag gac gcc tac gac ggc aag gat tac atc gcc ctg aac
gag gac 543Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn
Glu Asp 140 145 150ctg cgc tct tgg acc gcg gcg gac atg gca gct cag
atc acc aag cgc 591Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln
Ile Thr Lys Arg 155 160 165aag tgg gag gcg gtc cat gcg gcg gag cag
cgg aga gtc tac ctg gag 639Lys Trp Glu Ala Val His Ala Ala Glu Gln
Arg Arg Val Tyr Leu Glu170 175 180 185ggc cgg tgc gtg gac ggg ctc
cgc aga tac ctg gag aac ggg aag gag 687Gly Arg Cys Val Asp Gly Leu
Arg Arg Tyr Leu Glu Asn Gly Lys Glu 190 195 200acg ctg cag cgc acg
gac ccc ccc aag aca cat atg acc cac cac ccc 735Thr Leu Gln Arg Thr
Asp Pro Pro Lys Thr His Met Thr His His Pro 205 210 215atc tct gac
cat gag gcc acc ctg agg tgc tgg gcc ctg ggc ttc tac 783Ile Ser Asp
His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 220 225 230cct
gcg gag atc aca ctg acc tgg cag cgg gat ggg gag gac cag acc 831Pro
Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 235 240
245cag gac acg gag ctc gtg gag acc agg cct gca ggg gat gga acc ttc
879Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr
Phe250 255 260 265cag aag tgg gcg gct gtg gtg gtg cct tct gga gag
gag cag aga tac 927Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu
Glu Gln Arg Tyr 270 275 280acc tgc cat gtg cag cat gag ggt ctg ccc
aag ccc ctc acc ctg aga 975Thr Cys His Val Gln His Glu Gly Leu Pro
Lys Pro Leu Thr Leu Arg 285 290 295tgg gag ctg tct tcc cag ccc acc
atc ccc atc gtg ggc atc att gct 1023Trp Glu Leu Ser Ser Gln Pro Thr
Ile Pro Ile Val Gly Ile Ile Ala 300 305 310ggc ctg gtt ctc ctt gga
gct gtg atc act gga gct gtg gtc gct gcc 1071Gly Leu Val Leu Leu Gly
Ala Val Ile Thr Gly Ala Val Val Ala Ala 315 320 325gtg atg tgg agg
agg aag agc tca gat aga aaa gga ggg agt tac act 1119Val Met Trp Arg
Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Thr330 335 340 345cag
gct gca agc agt gac agt gcc cag ggc tct gat gtg tct ctc aca 1167Gln
Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr 350 355
360gct tgt aaa gtg tga gacagctgcc ttgtgtggga ctgagaggca agagttgttc
1222Ala Cys Lys Val 365ctgcccttcc ctttgtgact tgaagaaccc tgactttgtt
tctgcaaagg cacctgcatg 1282tgtctgtgtt cgtgtaggca taatgtgagg
aggtggggag agcaccccac ccccatgtcc 1342accatgaccc tcttcccacg
ctgacctgtg ctccctctcc aatcatcttt cctgttccag 1402agaggtgggg
ctgaggtgtc tccatctctg tctcaacttc atggtgcact gagctgtaac
1462ttcttccttc cctattaaaa ttagaacctg agtataaatt tactttctca
aattcttgcc 1522atgagaggtt gatgagttaa ttaaaggaga agattcctaa
aatttgagag acaaaattaa 1582tggaacgcat gagaaccttc cagagtcca
16114365PRTHomo sapiens 4Met Ala Val Met Ala Pro Arg Thr Leu Leu
Leu Leu Leu Ser Gly Ala 1 5 10 15 Leu Ala Leu Thr Gln Thr Trp Ala
Gly Ser His Ser Met Arg Tyr Phe 20 25 30 Phe Thr Ser Val Ser Arg
Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 35 40 45 Val Gly Tyr Val
Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 50 55 60 Ala Ser
Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 65 70 75 80
Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 85
90 95 Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln
Ser 100 105 110 Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys
Asp Val Gly 115 120 125 Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln
Asp Ala Tyr Asp Gly 130 135 140 Lys Asp Tyr Ile Ala Leu Asn Glu Asp
Leu Arg Ser Trp Thr Ala Ala 145 150 155 160 Asp Met Ala Ala Gln Ile
Thr Lys Arg Lys Trp Glu Ala Val His Ala 165 170 175 Ala Glu Gln Arg
Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 180 185 190 Arg Arg
Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 195 200 205
Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 210
215 220 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu
Thr 225 230 235 240 Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr
Glu Leu Val Glu 245 250 255 Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln
Lys Trp Ala Ala Val Val 260 265 270 Val Pro Ser Gly Glu Glu Gln Arg
Tyr Thr Cys His Val Gln His Glu 275 280 285 Gly Leu Pro Lys Pro Leu
Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 290 295 300 Thr Ile Pro Ile
Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 305 310 315 320 Val
Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 325 330
335 Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser
340 345 350 Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 355
360 365 51578DNAHomo sapiensCDS(55)..(1143) 5agttctaaag tccccacgca
cccacccgga ctcagagtct cctcagacgc cgag atg 57 Met 1ctg gtc atg gcg
ccc cga acc gtc ctc ctg ctg ctc tcg gcg gcc ctg 105Leu Val Met Ala
Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala Leu 5 10 15gcc ctg acc
gag acc tgg gcc ggc tcc cac tcc atg agg tat ttc tac 153Ala Leu Thr
Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe Tyr 20 25 30acc tcc
gtg tcc cgg ccc ggc cgc ggg gag ccc cgc ttc atc tca gtg 201Thr Ser
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val 35 40 45ggc
tac gtg gac gac acc cag ttc gtg agg ttc gac agc gac gcc gcg 249Gly
Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala50 55 60
65agt ccg aga gag gag ccg cgg gcg ccg tgg ata gag cag gag ggg ccg
297Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro
70 75 80gag tat tgg gac cgg aac aca cag atc tac aag gcc cag gca cag
act 345Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln
Thr 85 90 95gac cga gag agc ctg cgg aac ctg cgc ggc tac tac aac cag
agc gag 393Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln
Ser Glu 100 105 110gcc ggg tct cac acc ctc cag agc atg tac ggc tgc
gac gtg ggg ccg 441Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys
Asp Val Gly Pro 115 120 125gac ggg cgc ctc ctc cgc ggg cat gac cag
tac gcc tac gac ggc aag 489Asp Gly Arg Leu Leu Arg Gly His Asp Gln
Tyr Ala Tyr Asp Gly Lys130 135 140 145gat tac atc gcc ctg aac gag
gac ctg cgc tcc tgg acc gcc gcg gac 537Asp Tyr Ile Ala Leu Asn Glu
Asp Leu Arg Ser Trp Thr Ala Ala Asp 150 155 160acg gcg gct cag atc
acc cag cgc aag tgg gag gcg gcc cgt gag gcg 585Thr Ala Ala Gln Ile
Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu Ala 165 170 175gag cag cgg
aga gcc tac ctg gag ggc gag tgc gtg gag tgg ctc cgc 633Glu Gln Arg
Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg 180 185 190aga
tac ctg gag aac ggg aag gac aag ctg gag cgc gct gac ccc cca 681Arg
Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro Pro 195 200
205aag aca cac gtg acc cac cac ccc atc tct gac cat gag gcc acc ctg
729Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr
Leu210 215 220 225agg tgc tgg gcc ctg ggt ttc tac cct gcg gag atc
aca ctg acc tgg 777Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile
Thr Leu Thr Trp 230 235 240cag cgg gat ggc gag gac caa act cag gac
act gag ctt gtg gag acc 825Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp
Thr Glu Leu Val Glu Thr 245 250 255aga cca gca gga gat aga acc ttc
cag aag tgg gca gct gtg gtg gtg 873Arg Pro Ala Gly Asp Arg Thr Phe
Gln Lys Trp Ala Ala Val Val Val 260 265 270cct tct gga gaa gag cag
aga tac aca tgc cat gta cag cat gag ggg 921Pro Ser Gly Glu Glu Gln
Arg Tyr Thr Cys His Val Gln His Glu Gly 275 280 285ctg ccg aag ccc
ctc acc ctg aga tgg gag ccg tct tcc cag tcc acc 969Leu Pro Lys Pro
Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser Thr290 295 300 305gtc
ccc atc gtg ggc att gtt gct ggc ctg gct gtc cta gca gtt gtg 1017Val
Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val 310 315
320gtc atc gga gct gtg gtc gct gct gtg atg tgt agg agg aag agt tca
1065Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser
325 330 335ggt gga aaa gga ggg agc tac tct cag gct gcg tgc agc gac
agt gcc 1113Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp
Ser Ala 340 345 350cag ggc tct gat gtg tct ctc aca gct tga
aaagcctgag acagctgtct 1163Gln Gly Ser Asp Val Ser Leu Thr Ala 355
360tgtgagggac tgagatgcag gatttcttca cgcctcccct ttgtgacttc
aagagcctct 1223ggcatctctt tctgcaaagg cacctgaatg tgtctgcgtc
cctgttagca taatgtgagg 1283aggtggagag acagcccacc cttgtgtcca
ctgtgacccc tgttcccatg ctgacctgtg 1343tttcctcccc agtcatcttt
cttgttccag agaggtgggg ctggatgtct ccatctctgt 1403ctcaacttta
cgtgcactga gctgcaactt cttacttccc tactgaaaat aagaatctga
1463atataaattt gttttctcaa atatttgcta tgagaggttg atggattaat
taaataagtc 1523aattcctgga atttgagaga gcaaataaag acctgagaac
cttccagaaa aaaaa 15786362PRTHomo sapiens 6Met Leu Val Met Ala Pro
Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 1 5 10 15 Leu Ala Leu Thr
Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 20 25 30 Tyr Thr
Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 35 40 45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 50
55 60 Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu
Gly 65 70 75 80 Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala
Gln Ala Gln 85 90 95 Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly
Tyr Tyr Asn Gln Ser 100 105 110 Glu Ala Gly Ser His Thr Leu Gln Ser
Met Tyr Gly Cys Asp Val Gly 115 120 125 Pro Asp Gly Arg Leu Leu Arg
Gly His Asp Gln Tyr Ala Tyr Asp Gly 130 135 140 Lys Asp Tyr Ile Ala
Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 145 150 155 160 Asp Thr
Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 165 170 175
Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 180
185 190 Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp
Pro 195 200 205 Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His
Glu Ala Thr 210 215 220 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala
Glu Ile Thr Leu Thr 225 230 235 240 Trp Gln Arg Asp Gly Glu Asp Gln
Thr Gln Asp Thr Glu Leu Val Glu
245 250 255 Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala
Val Val 260 265 270 Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His
Val Gln His Glu 275 280 285 Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp
Glu Pro Ser Ser Gln Ser 290 295 300 Thr Val Pro Ile Val Gly Ile Val
Ala Gly Leu Ala Val Leu Ala Val 305 310 315 320 Val Val Ile Gly Ala
Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 325 330 335 Ser Gly Gly
Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 340 345 350 Ala
Gln Gly Ser Asp Val Ser Leu Thr Ala 355 360 71586DNAHomo
sapiensCDS(66)..(1166) 7tccgcagtcc cggttctaaa gtccccagtc acccacccgg
actcacattc tccccagagg 60ccgag atg cgg gtc atg gcg ccc cga gcc ctc
ctc ctg ctg ctc tcg gga 110 Met Arg Val Met Ala Pro Arg Ala Leu Leu
Leu Leu Leu Ser Gly 1 5 10 15ggc ctg gcc ctg acc gag acc tgg gcc
tgc tcc cac tcc atg agg tat 158Gly Leu Ala Leu Thr Glu Thr Trp Ala
Cys Ser His Ser Met Arg Tyr 20 25 30ttc gac acc gcc gtg tcc cgg ccc
ggc cgc gga gag ccc cgc ttc atc 206Phe Asp Thr Ala Val Ser Arg Pro
Gly Arg Gly Glu Pro Arg Phe Ile 35 40 45tca gtg ggc tac gtg gac gac
acg cag ttc gtg cgg ttc gac agc gac 254Ser Val Gly Tyr Val Asp Asp
Thr Gln Phe Val Arg Phe Asp Ser Asp 50 55 60gcc gcg agt ccg aga ggg
gag ccg cgg gcg ccg tgg gtg gag cag gag 302Ala Ala Ser Pro Arg Gly
Glu Pro Arg Ala Pro Trp Val Glu Gln Glu 65 70 75ggg ccg gag tat tgg
gac cgg gag aca cag aag tac aag cgc cag gca 350Gly Pro Glu Tyr Trp
Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala80 85 90 95cag gct gac
cga gtg agc ctg cgg aac ctg cgc ggc tac tac aac cag 398Gln Ala Asp
Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln 100 105 110agc
gag gac ggg tct cac acc ctc cag agg atg tct ggc tgc gac ctg 446Ser
Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu 115 120
125ggg ccc gac ggg cgc ctc ctc cgc ggg tat gac cag tcc gcc tac gac
494Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp
130 135 140ggc aag gat tac atc gcc ctg aac gag gac ctg cgc tcc tgg
acc gcc 542Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp
Thr Ala 145 150 155gcg gac acc gcg gct cag atc acc cag cgc aag ttg
gag gcg gcc cgt 590Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu
Glu Ala Ala Arg160 165 170 175gcg gcg gag cag ctg aga gcc tac ctg
gag ggc acg tgc gtg gag tgg 638Ala Ala Glu Gln Leu Arg Ala Tyr Leu
Glu Gly Thr Cys Val Glu Trp 180 185 190ctc cgc aga tac ctg gag aac
ggg aag gag acg ctg cag cgc gca gaa 686Leu Arg Arg Tyr Leu Glu Asn
Gly Lys Glu Thr Leu Gln Arg Ala Glu 195 200 205ccc cca aag aca cac
gtg acc cac cac ccc ctc tct gac cat gag gcc 734Pro Pro Lys Thr His
Val Thr His His Pro Leu Ser Asp His Glu Ala 210 215 220acc ctg agg
tgc tgg gcc ctg ggc ttc tac cct gcg gag atc aca ctg 782Thr Leu Arg
Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu 225 230 235acc
tgg cag cgg gat ggg gag gac cag acc cag gac acc gag ctt gtg 830Thr
Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val240 245
250 255gag acc agg cca gca gga gat gga acc ttc cag aag tgg gca gct
gtg 878Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala
Val 260 265 270gtg gtg cct tct gga caa gag cag aga tac acg tgc cat
atg cag cac 926Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His
Met Gln His 275 280 285gag ggg ctg caa gag ccc ctc acc ctg agc tgg
gag cca tct tcc cag 974Glu Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp
Glu Pro Ser Ser Gln 290 295 300ccc acc atc ccc atc atg ggc atc gtt
gct ggc ctg gct gtc ctg gtt 1022Pro Thr Ile Pro Ile Met Gly Ile Val
Ala Gly Leu Ala Val Leu Val 305 310 315gtc cta gct gtc ctt gga gct
gtg gtc acc gct atg atg tgt agg agg 1070Val Leu Ala Val Leu Gly Ala
Val Val Thr Ala Met Met Cys Arg Arg320 325 330 335aag agc tca ggt
gga aaa gga ggg agc tgc tct cag gct gcg tgc agc 1118Lys Ser Ser Gly
Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser 340 345 350aac agt
gcc cag ggc tct gat gag tct ctc atc act tgt aaa gcc tga 1166Asn Ser
Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 355 360
365gacagctgcc tgtgtgggac tgagatgcag gatttcttca cacctctcct
ttgtgacttc 1226aagagcctct ggcatctctt tctgcaaagg cacctgaatg
tgtctgcgtt cctgttagca 1286taatgtgagg aggtggagag acagcccacc
cccgtgtcca ccgtgacccc tgtccccaca 1346ctgacctgtg ttccctcccc
gatcatcttt cctgttccag agaggtgggg ctggatgtct 1406ccatctctgt
ctcaaattca tggtgcactg agctgcaact tcttacttcc ctaatgaagt
1466taagaacctg aatataaatt tgtgttctca aatatttgct atgaagcgtt
gatggattaa 1526ttaaataagt caattcctag aagttgagag agcaaataaa
gacctgagaa ccttccagaa 15868366PRTHomo sapiens 8Met Arg Val Met Ala
Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 1 5 10 15 Leu Ala Leu
Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 20 25 30 Asp
Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 35 40
45 Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala
50 55 60 Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln
Glu Gly 65 70 75 80 Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys
Arg Gln Ala Gln 85 90 95 Ala Asp Arg Val Ser Leu Arg Asn Leu Arg
Gly Tyr Tyr Asn Gln Ser 100 105 110 Glu Asp Gly Ser His Thr Leu Gln
Arg Met Ser Gly Cys Asp Leu Gly 115 120 125 Pro Asp Gly Arg Leu Leu
Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 130 135 140 Lys Asp Tyr Ile
Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 145 150 155 160 Asp
Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 165 170
175 Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu
180 185 190 Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala
Glu Pro 195 200 205 Pro Lys Thr His Val Thr His His Pro Leu Ser Asp
His Glu Ala Thr 210 215 220 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro
Ala Glu Ile Thr Leu Thr 225 230 235 240 Trp Gln Arg Asp Gly Glu Asp
Gln Thr Gln Asp Thr Glu Leu Val Glu 245 250 255 Thr Arg Pro Ala Gly
Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 260 265 270 Val Pro Ser
Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 275 280 285 Gly
Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 290 295
300 Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val
305 310 315 320 Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys
Arg Arg Lys 325 330 335 Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln
Ala Ala Cys Ser Asn 340 345 350 Ser Ala Gln Gly Ser Asp Glu Ser Leu
Ile Thr Cys Lys Ala 355 360 365 92679DNAHomo
sapiensCDS(127)..(1203) 9gcagactcag ttctcattcc caatgggtgt
cgggtttcta gagaagccaa tcagcgtcgc 60cacgactccc gactataaag tccccatccg
gactcaagaa gttctcagga ctcagaggct 120gggatc atg gta gat gga acc ctc
ctt tta ctc ctc tcg gag gcc ctg 168 Met Val Asp Gly Thr Leu Leu Leu
Leu Leu Ser Glu Ala Leu 1 5 10gcc ctt acc cag acc tgg gcg ggc tcc
cac tcc ttg aag tat ttc cac 216Ala Leu Thr Gln Thr Trp Ala Gly Ser
His Ser Leu Lys Tyr Phe His15 20 25 30act tcc gtg tcc cgg ccc ggc
cgc ggg gag ccc cgc ttc atc tct gtg 264Thr Ser Val Ser Arg Pro Gly
Arg Gly Glu Pro Arg Phe Ile Ser Val 35 40 45ggc tac gtg gac gac acc
cag ttc gtg cgc ttc gac aac gac gcc gcg 312Gly Tyr Val Asp Asp Thr
Gln Phe Val Arg Phe Asp Asn Asp Ala Ala 50 55 60agt ccg agg atg gtg
ccg cgg gcg ccg tgg atg gag cag gag ggg tca 360Ser Pro Arg Met Val
Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser 65 70 75gag tat tgg gac
cgg gag aca cgg agc gcc agg gac acc gca cag att 408Glu Tyr Trp Asp
Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile 80 85 90ttc cga gtg
aat ctg cgg acg ctg cgc ggc tac tac aat cag agc gag 456Phe Arg Val
Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu95 100 105
110gcc ggg tct cac acc ctg cag tgg atg cat ggc tgc gag ctg ggg ccc
504Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro
115 120 125gac ggg cgc ttc ctc cgc ggg tat gaa cag ttc gcc tac gac
ggc aag 552Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp
Gly Lys 130 135 140gat tat ctc acc ctg aat gag gac ctg cgc tcc tgg
acc gcg gtg gac 600Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp
Thr Ala Val Asp 145 150 155acg gcg gct cag atc tcc gag caa aag tca
aat gat gcc tct gag gcg 648Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser
Asn Asp Ala Ser Glu Ala 160 165 170gag cac cag aga gcc tac ctg gaa
gac aca tgc gtg gag tgg ctc cac 696Glu His Gln Arg Ala Tyr Leu Glu
Asp Thr Cys Val Glu Trp Leu His175 180 185 190aaa tac ctg gag aag
ggg aag gag acg ctg ctt cac ctg gag ccc cca 744Lys Tyr Leu Glu Lys
Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro 195 200 205aag aca cac
gtg act cac cac ccc atc tct gac cat gag gcc acc ctg 792Lys Thr His
Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu 210 215 220agg
tgc tgg gcc ctg ggc ttc tac cct gcg gag atc aca ctg acc tgg 840Arg
Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 225 230
235cag cag gat ggg gag ggc cat acc cag gac acg gag ctc gtg gag acc
888Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr
240 245 250agg cct gca ggg gat gga acc ttc cag aag tgg gca gct gtg
gtg gtg 936Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val
Val Val255 260 265 270cct tct gga gag gag cag aga tac acg tgc cat
gtg cag cat gag ggg 984Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His
Val Gln His Glu Gly 275 280 285cta ccc gag ccc gtc acc ctg aga tgg
aag ccg gct tcc cag ccc acc 1032Leu Pro Glu Pro Val Thr Leu Arg Trp
Lys Pro Ala Ser Gln Pro Thr 290 295 300atc ccc atc gtg ggc atc att
gct ggc ctg gtt ctc ctt gga tct gtg 1080Ile Pro Ile Val Gly Ile Ile
Ala Gly Leu Val Leu Leu Gly Ser Val 305 310 315gtc tct gga gct gtg
gtt gct gct gtg ata tgg agg aag aag agc tca 1128Val Ser Gly Ala Val
Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser 320 325 330ggt gga aaa
gga ggg agc tac tct aag gct gag tgg agc gac agt gcc 1176Gly Gly Lys
Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala335 340 345
350cag ggg tct gag tct cac agc ttg taa agcctgagac agctgccttg
1223Gln Gly Ser Glu Ser His Ser Leu 355tgtgcgactg agatgcacag
ctgccttgtg tgcgactgag atgcaggatt tcctcacgcc 1283tcccctatgt
gtcttagggg actctggctt ctctttttgc aagggcctct gaatctgtct
1343gtgtccctgt tagcacaatg tgaggaggta gagaaacagt ccacctctgt
gtctaccatg 1403acccccttcc tcacactgac ctgtgttcct tccctgttct
cttttctatt aaaaataaga 1463acctgggcag agtgcggcag ctcatgcctg
taatcccagc acttagggag gccgaggagg 1523gcagatcacg aggtcaggag
atcgaaacca tcctggctaa cacggtgaaa ccccgtctct 1583actaaaaaat
acaaaaaatt agctgggcgc agaggcacgg gcctgtagtc ccagctactc
1643aggaggcgga ggcaggagaa tggcgtcaac ccgggaggcg gaggttgcag
tgagccagga 1703ttgtgcgact gcactccagc ctgggtgaca gggtgaaacg
ccatctcaaa aaataaaaat 1763tgaaaaataa aaaaagaacc tggatctcaa
tttaattttt catattcttg caatgaaatg 1823gacttgagga agctaagatc
atagctagaa atacagataa ttccacagca catctctagc 1883aaatttagcc
tattcctatt ctctagccta ttccttacca cctgtaatct tgaccatata
1943ccttggagtt gaatattgtt ttcatactgc tgtggtttga atgttccctc
caacactcat 2003gttgagactt aatccctaat gtggcaatac tgaaaggtgg
ggcctttgag atgtgattgg 2063atcgtaaggc tgtgccttca ttcatgggtt
aatggattaa tgggttatca caggaatggg 2123actggtggct ttataagaag
aggaaaagag aactgagcta gcatgcccag cccacagaga 2183gcctccacta
gagtgatgct aagtggaaat gtgaggtgca gctgccacag agggccccca
2243ccagggaaat gtctagtgtc tagtggatcc aggccacagg agagagtgcc
ttgtggagcg 2303ctgggagcag gacctgacca ccaccaggac cccagaactg
tggagtcagt ggcagcatgc 2363agcgccccct tgggaaagct ttaggcacca
gcctgcaacc cattcgagca gccacgtagg 2423ctgcacccag caaagccaca
ggcacggggc tacctgaggc cttgggggcc caatccctgc 2483tccagtgtgt
ccgtgaggca gcacacgaag tcaaaagaga ttattctctt cccacagata
2543ccttttctct cccatgaccc tttaacagca tctgcttcat tcccctcacc
ttcccaggct 2603gatctgaggt aaactttgaa gtaaaataaa agctgtgttt
gagcatcatt tgtatttcaa 2663aaaaaaaaaa aaaaaa 267910358PRTHomo
sapiens 10Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu
Ala Leu 1 5 10 15 Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr
Phe His Thr Ser 20 25 30 Val Ser Arg Pro Gly Arg Gly Glu Pro Arg
Phe Ile Ser Val Gly Tyr 35 40 45 Val Asp Asp Thr Gln Phe Val Arg
Phe Asp Asn Asp Ala Ala Ser Pro 50 55 60 Arg Met Val Pro Arg Ala
Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 65 70 75 80 Trp Asp Arg Glu
Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 85 90 95 Val Asn
Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 100 105 110
Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 115
120 125 Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp
Tyr 130 135 140 Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val
Asp Thr Ala 145 150 155 160 Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp
Ala Ser Glu Ala Glu His 165 170 175 Gln Arg Ala Tyr Leu Glu Asp Thr
Cys Val Glu Trp Leu His Lys Tyr 180 185 190 Leu Glu Lys Gly Lys Glu
Thr Leu Leu His Leu Glu Pro Pro Lys Thr 195 200 205 His Val Thr His
His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 210 215 220 Trp Ala
Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 225 230 235
240 Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro
245 250 255 Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val
Pro Ser 260 265 270 Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His
Glu Gly Leu Pro 275 280 285 Glu Pro Val Thr Leu Arg Trp Lys Pro Ala
Ser Gln Pro Thr Ile Pro 290 295 300 Ile Val Gly Ile Ile Ala Gly Leu
Val Leu Leu Gly Ser Val Val Ser 305 310 315 320 Gly Ala Val Val Ala
Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 325 330 335 Lys Gly Gly
Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 340 345 350 Ser
Glu Ser His Ser Leu 355 111301DNAHomo sapiensCDS(125)..(1165)
11tttctcactc ccattgggcg tcgcgtttct agagaagcca atcagtgtcg ccgcagttcc
60caggttctaa agtcccacgc accccgcggg actcatattt ttcccagacg cggaggttgg
120ggtc atg gcg ccc cga agc ctc ctc ctg ctg ctc tca ggg gcc ctg gcc
169 Met Ala Pro Arg Ser Leu Leu
Leu Leu Leu Ser Gly Ala Leu Ala 1 5 10 15ctg acc gat act tgg gcg
ggc tcc cac tcc ttg agg tat ttc agc acc 217Leu Thr Asp Thr Trp Ala
Gly Ser His Ser Leu Arg Tyr Phe Ser Thr 20 25 30gct gtg tcg cgg ccc
ggc cgc ggg gag ccc cgc tac atc gcc gtg gag 265Ala Val Ser Arg Pro
Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu 35 40 45tac gta gac gac
acg caa ttc ctg cgg ttc gac agc gac gcc gcg att 313Tyr Val Asp Asp
Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile 50 55 60ccg agg atg
gag ccg cgg gag ccg tgg gtg gag caa gag ggg ccg cag 361Pro Arg Met
Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln 65 70 75tat tgg
gag tgg acc aca ggg tac gcc aag gcc aac gca cag act gac 409Tyr Trp
Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp80 85 90
95cga gtg gcc ctg agg aac ctg ctc cgc cgc tac aac cag agc gag gct
457Arg Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala
100 105 110ggg tct cac acc ctc cag gga atg aat ggc tgc gac atg ggg
ccc gac 505Gly Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly
Pro Asp 115 120 125gga cgc ctc ctc cgc ggg tat cac cag cac gcg tac
gac ggc aag gat 553Gly Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr
Asp Gly Lys Asp 130 135 140tac atc tcc ctg aac gag gac ctg cgc tcc
tgg acc gcg gcg gac acc 601Tyr Ile Ser Leu Asn Glu Asp Leu Arg Ser
Trp Thr Ala Ala Asp Thr 145 150 155gtg gct cag atc acc cag cgc ttc
tat gag gca gag gaa tat gca gag 649Val Ala Gln Ile Thr Gln Arg Phe
Tyr Glu Ala Glu Glu Tyr Ala Glu160 165 170 175gag ttc agg acc tac
ctg gag ggc gag tgc ctg gag ttg ctc cgc aga 697Glu Phe Arg Thr Tyr
Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg 180 185 190tac ttg gag
aat ggg aag gag acg cta cag cgc gca gat cct cca aag 745Tyr Leu Glu
Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys 195 200 205gca
cac gtt gcc cac cac ccc atc tct gac cat gag gcc acc ctg agg 793Ala
His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg 210 215
220tgc tgg gcc ctg ggc ttc tac cct gcg gag atc acg ctg acc tgg cag
841Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln
225 230 235cgg gat ggg gag gaa cag acc cag gac aca gag ctt gtg gag
acc agg 889Arg Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu
Thr Arg240 245 250 255cct gca ggg gat gga acc ttc cag aag tgg gcc
gct gtg gtg gtg cct 937Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala
Ala Val Val Val Pro 260 265 270cct gga gag gaa cag aga tac aca tgc
cat gtg cag cac gag ggg ctg 985Pro Gly Glu Glu Gln Arg Tyr Thr Cys
His Val Gln His Glu Gly Leu 275 280 285ccc cag ccc ctc atc ctg aga
tgg gag cag tct ccc cag ccc acc atc 1033Pro Gln Pro Leu Ile Leu Arg
Trp Glu Gln Ser Pro Gln Pro Thr Ile 290 295 300ccc atc gtg ggc atc
gtt gct ggc ctt gtt gtc ctt gga gct gtg gtc 1081Pro Ile Val Gly Ile
Val Ala Gly Leu Val Val Leu Gly Ala Val Val 305 310 315act gga gct
gtg gtc gct gct gtg atg tgg agg aag aag agc tca gat 1129Thr Gly Ala
Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp320 325 330
335aga aac aga ggg agc tac tct cag gct gca gtg tga gacagcttcc
1175Arg Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 340 345ttgtgtggga
ctgagaagca agatatcaat gtagcagaat tgcacttgtg cctcacgaac
1235atacataaat tttaaaaata aagaataaaa atatatcttt ttatagataa
aaaaaaaaaa 1295aaaaaa 130112346PRTHomo sapiens 12Met Ala Pro Arg
Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 1 5 10 15 Thr Asp
Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 20 25 30
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 35
40 45 Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile
Pro 50 55 60 Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly
Pro Gln Tyr 65 70 75 80 Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn
Ala Gln Thr Asp Arg 85 90 95 Val Ala Leu Arg Asn Leu Leu Arg Arg
Tyr Asn Gln Ser Glu Ala Gly 100 105 110 Ser His Thr Leu Gln Gly Met
Asn Gly Cys Asp Met Gly Pro Asp Gly 115 120 125 Arg Leu Leu Arg Gly
Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 130 135 140 Ile Ser Leu
Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 145 150 155 160
Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 165
170 175 Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg
Tyr 180 185 190 Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro
Pro Lys Ala 195 200 205 His Val Ala His His Pro Ile Ser Asp His Glu
Ala Thr Leu Arg Cys 210 215 220 Trp Ala Leu Gly Phe Tyr Pro Ala Glu
Ile Thr Leu Thr Trp Gln Arg 225 230 235 240 Asp Gly Glu Glu Gln Thr
Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 245 250 255 Ala Gly Asp Gly
Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 260 265 270 Gly Glu
Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 275 280 285
Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 290
295 300 Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val
Thr 305 310 315 320 Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys
Ser Ser Asp Arg 325 330 335 Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val
340 345 131578DNAHomo sapiensCDS(179)..(1195) 13agtgtggtac
tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga 60atgaagttct
cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg
120gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaagg
178atg gtg gtc atg gcg ccc cga acc ctc ttc ctg ctg ctc tcg ggg gcc
226Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala1
5 10 15ctg acc ctg acc gag acc tgg gcg ggc tcc cac tcc atg agg tat
ttc 274Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr
Phe 20 25 30agc gcc gcc gtg tcc cgg ccc ggc cgc ggg gag ccc cgc ttc
atc gcc 322Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe
Ile Ala 35 40 45atg ggc tac gtg gac gac acg cag ttc gtg cgg ttc gac
agc gac tcg 370Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp
Ser Asp Ser 50 55 60gcg tgt ccg agg atg gag ccg cgg gcg ccg tgg gtg
gag cag gag ggg 418Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val
Glu Gln Glu Gly65 70 75 80ccg gag tat tgg gaa gag gag aca cgg aac
acc aag gcc cac gca cag 466Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn
Thr Lys Ala His Ala Gln 85 90 95act gac aga atg aac ctg cag acc ctg
cgc ggc tac tac aac cag agc 514Thr Asp Arg Met Asn Leu Gln Thr Leu
Arg Gly Tyr Tyr Asn Gln Ser 100 105 110gag gcc agt tct cac acc ctc
cag tgg atg att ggc tgc gac ctg ggg 562Glu Ala Ser Ser His Thr Leu
Gln Trp Met Ile Gly Cys Asp Leu Gly 115 120 125tcc gac gga cgc ctc
ctc cgc ggg tat gaa cag tat gcc tac gat ggc 610Ser Asp Gly Arg Leu
Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 130 135 140aag gat tac
ctc gcc ctg aac gag gac ctg cgc tcc tgg acc gca gcg 658Lys Asp Tyr
Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala145 150 155
160gac act gcg gct cag atc tcc aag cgc aag tgt gag gcg gcc aat gtg
706Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val
165 170 175gct gaa caa agg aga gcc tac ctg gag ggc acg tgc gtg gag
tgg ctc 754Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu
Trp Leu 180 185 190cac aga tac ctg gag aac ggg aag gag atg ctg cag
cgc gcg gac ccc 802His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln
Arg Ala Asp Pro 195 200 205ccc aag aca cac gtg acc cac cac cct gtc
ttt gac tat gag gcc acc 850Pro Lys Thr His Val Thr His His Pro Val
Phe Asp Tyr Glu Ala Thr 210 215 220ctg agg tgc tgg gcc ctg ggc ttc
tac cct gcg gag atc ata ctg acc 898Leu Arg Cys Trp Ala Leu Gly Phe
Tyr Pro Ala Glu Ile Ile Leu Thr225 230 235 240tgg cag cgg gat ggg
gag gac cag acc cag gac gtg gag ctc gtg gag 946Trp Gln Arg Asp Gly
Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 245 250 255acc agg cct
gca ggg gat gga acc ttc cag aag tgg gca gct gtg gtg 994Thr Arg Pro
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 260 265 270gtg
cct tct gga gag gag cag aga tac acg tgc cat gtg cag cat gag 1042Val
Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 275 280
285ggg ctg ccg gag ccc ctc atg ctg aga tgg aag cag tct tcc ctg ccc
1090Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro
290 295 300acc atc ccc atc atg ggt atc gtt gct ggc ctg gtt gtc ctt
gca gct 1138Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu
Ala Ala305 310 315 320gta gtc act gga gct gcg gtc gct gct gtg ctg
tgg aga aag aag agc 1186Val Val Thr Gly Ala Ala Val Ala Ala Val Leu
Trp Arg Lys Lys Ser 325 330 335tca gat tga aaaggaggga gctactctca
ggctgcaatg tgaaacagct 1235Ser Asp gccctgtgtg ggactgagtg gcaagtccct
ttgtgacttc aagaaccctg actcctcttt 1295gtgcagagac cagcccaccc
ctgtgcccac catgaccctc ttcctcatgc tgaactgcat 1355tccttcccca
atcacctttc ctgttccaga aaaggggctg ggatgtctcc gtctctgtct
1415caaatttgtg gtccactgag ctataactta cttctgtatt aaaattagaa
tctgagtata 1475aatttacttt ttcaaattat ttccaagaga gattgatggg
ttaattaaag gagaagattc 1535ctgaaatttg agagacaaaa taaatggaag
acatgagaac ttt 157814338PRTHomo sapiens 14Met Val Val Met Ala Pro
Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 1 5 10 15 Leu Thr Leu Thr
Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 20 25 30 Ser Ala
Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 35 40 45
Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 50
55 60 Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu
Gly 65 70 75 80 Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala
His Ala Gln 85 90 95 Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly
Tyr Tyr Asn Gln Ser 100 105 110 Glu Ala Ser Ser His Thr Leu Gln Trp
Met Ile Gly Cys Asp Leu Gly 115 120 125 Ser Asp Gly Arg Leu Leu Arg
Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 130 135 140 Lys Asp Tyr Leu Ala
Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 145 150 155 160 Asp Thr
Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 165 170 175
Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 180
185 190 His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp
Pro 195 200 205 Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr
Glu Ala Thr 210 215 220 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala
Glu Ile Ile Leu Thr 225 230 235 240 Trp Gln Arg Asp Gly Glu Asp Gln
Thr Gln Asp Val Glu Leu Val Glu 245 250 255 Thr Arg Pro Ala Gly Asp
Gly Thr Phe Gln Lys Trp Ala Ala Val Val 260 265 270 Val Pro Ser Gly
Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 275 280 285 Gly Leu
Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 290 295 300
Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 305
310 315 320 Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys
Lys Ser 325 330 335 Ser Asp 159232DNAArtificial SequenceVector
sequence for human B2M-HLA-A0201 fusion protein 15ctcgaggagc
ttggcccatt gcatacgttg tatccatatc ataatatgta catttatatt 60ggctcatgtc
caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa
120tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac
ataacttacg 180gtaaatggcc cgcctggctg accgcccaac gacccccgcc
cattgacgtc aataatgacg 240tatgttccca tagtaacgcc aatagggact
ttccattgac gtcaatgggt ggagtattta 300cgctaaactg cccacttggc
agtacatcaa gtgtatcata tgccaagtac gccccctatt 360gacgtcaatg
acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac
420tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt
gatgcggttt 480tggcagtaca tcaatgggcg tggatagcgg tttgactcac
ggggatttcc aagtctccac 540cccattgacg tcaatgggag tttgttttgg
caccaaaatc aacgggactt tccaaaatgt 600cgtaacaact ccgccccatt
gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat 660ataagcagag
cttctagatt gtacgggagc tcttcactac tcgctgcgtc gagagtgtac
720gagactctcc aggtttggta agaaatattt tatattgtta taatgttact
atgatccatt 780aacactctgc ttatagattg taagggtgat tgcaatgctt
tctgcataaa actttggttt 840tcttgttaat caataaaccg acttgattcg
agaacctact catatattat tgtctctttt 900atactttatt aagtaaaagg
atttgtatat tagccttgct aagggagaca tctagtgata 960taagtgtgaa
ctacacttat cttaaatgat gtaactcctt aggataatca atatacaaaa
1020ttccatgaca attggcgccc aacgtggggc tcgaatataa gtcgggttta
tttgtaaatt 1080atccctaggg acctccgagc aagcgagcat agcgggaggc
atataaaagc caatagacaa 1140tggctagcag gaagtaatgt tgaagaatat
gaacttgatg ttgaagctct ggttgtaatt 1200ttaagagata gaaatatacc
aagaaatcct ttacatggag aagttatagg tcttcgcctt 1260actgaaggat
ggtggggaca aattgagaga tttcagatgg tacgttgatc taaggctatg
1320gatttggcca tgggacaaga aatattagtt tatagtccca ttgtatctat
gactaaaata 1380caaaaaactc cactaccaga aagaaaagct ttacccatta
gatggataac atggatgact 1440tatttagaag atccaagaat ccaatttcat
tatgataaaa ccttaccaga acttaagcat 1500attccagatg tatatacatc
tagtcagtct cctgttaaac atccttctca atatgaagga 1560gtgttttata
ctgatggctc ggccatcaaa agtcctgatc ctacaaaaag caataatgct
1620ggcatgggaa tagtacatgc cacatacaaa cctgaatatc aagttttgaa
tcaatggtca 1680ataccactag gtaatcatac tgctcagatg gctgaaatag
ctgcagttga atttgcctgt 1740aaaaaagctt taaaaatacc tggtcctgta
ttagttataa ctgatagttt ctatgtagca 1800gaaagtgcta ataaagaatt
accatactgg aaatctaatg ggtttgttaa taataagaaa 1860aagcctctta
aacatatctc caaatggaaa tctattgctg agtgtttatc tatgaaacca
1920gacattacta ttcaacatga aaaaggcatc agcctacaaa taccagtatt
catactgaaa 1980ggcaatgccc tagcagataa gcttgccacc caaggaagtt
atgtggttaa ttgtaatacc 2040aaaaaaccaa acctggatgc agagttggat
caattattac agggtcatta tataaaagga 2100tatcccaaac aatatacata
ttttttagaa gatggcaaag taaaagtttc cagacctgaa 2160ggggttaaaa
ttattccccc tcagtcagac agacaaaaaa ttgtgcttca agcccacaat
2220ttggctcaca ccggacgtga agccactctt ttaaaaattg ccaaccttta
ttggtggcca 2280aatatgagaa aggatgtggt taaacaacta ggacgctgtc
aacagtgttt aatcacaaat 2340gcttccaaca aagcctctgg tcctattcta
agaccagata ggcctcaaaa accttttgat 2400aaattcttta ttgactatat
tggacctttg ccaccttcac agggatacct atatgtatta 2460gtagttgttg
atggaatgac aggattcact tggttatacc ccactaaggc tccttctact
2520agcgcaactg ttaaatctct caatgtactc actagtattg caattccaaa
ggtgattcac 2580tctgatcaag gtgcagcatt cacttcttca acctttgctg
aatgggcaaa ggaaagaggt 2640atacatttgg aattcagtac tccttatcac
ccccaaagtg gtagtaaggt ggaaaggaaa 2700aatagtgata taaaacgact
tttaactaaa ctgctagtag gaagacccac aaagtggtat 2760gacctattgc
ctgttgtaca acttgcttta aacaacacct atagccctgt attaaaatat
2820actccacatc aactcttatt tggtatagat tcaaatactc catttgcaaa
tcaagataca 2880cttgacttga ccagagaaga agaactttct cttttacagg
aaattcgtac ttctttatac 2940catccatcca cccctccagc ctcctctcgt
tcctggtctc ctgttgttgg ccaattggtc 3000caggagaggg tggctaggcc
tgcttctttg
agacctcgtt ggcataaacc gtctactgta 3060cttaaggtgt tgaatccaag
gactgttgtt attttggacc atcttggcaa caacagaact 3120gtaagtatag
ataatttaaa acctacttct catcagaatg gcaccaccaa tgacactgca
3180acaatggatc atttggaaaa aaatgaataa agcgcatgag gcacttcaaa
atacaacaac 3240tgtgactgaa cagcagaagg aacaaattat actggacatt
caaaatgaag aagtacaacc 3300aactaggaga gataaattta gatatctgct
ttatacttgt tgtgctacta gctcaagagt 3360attggcctgg atgtttttag
tttgtatatt gttaatcatt gttttggttt catgctttgt 3420gactatatcc
agaatacaat ggaataagga tattcaggta ttaggacctg taatagactg
3480gaatgttact caaagagctg tttatcaacc cttacagact agaaggattg
cacgttccct 3540tagaatgcag catcctgttc caaaatatgt ggaggtaaat
atgactagta ttccacaagg 3600tgtatactat gaaccccatc cggcctcgac
ggtatcgatg gtaccggtat cgataagctt 3660gataacctcg agagatctaa
ttctaccggg taggggaggc gcttttccca aggcagtctg 3720gagcatgcgc
tttagcagcc ccgctggcac ttggcgctac acaagtggcc tctggcctcg
3780cacacattcc acatccaccg gtagcgccaa ccggctccgt tctttggtgg
ccccttcgcg 3840ccacttctac tcctccccta gtcaggaagt ttcccccagc
aagctcgcgt cgtgcaggac 3900gtgacaaatg gaagtagcac gtctcactag
tctcgtgcag atggacagca ccgctgagca 3960atggaagcgg gtaggccttt
ggggcagcgg ccaatagcag ctttgttcct tcgctttctg 4020ggctcagagg
ctgggaaggg gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg
4080gcgggcgccc gaaggtcctc ccgaggcccg gcattctgca cgcttcaaaa
gcgcacgtct 4140gccgcgctgt tctcctcttc ctcatctccg ggcctttcga
cctgcagccc gggggatcga 4200tcctaggtga tttaaatcca ccatgaccga
gtacaagccc acggtgcgcc tcgccacccg 4260cgacgacgtc ccccgggccg
tacgcaccct cgccgccgcg ttcgccgact accccgccac 4320gcgccacacc
gtcgacccgg accgccacat cgagcgggtc accgagctgc aagaactctt
4380cctcacgcgc gtcgggctcg acatcggcaa ggtgtgggtc gcggacgacg
gcgccgcggt 4440ggcggtctgg accacgccgg agagcgtcga agcgggggcg
gtgttcgccg agatcggccc 4500gcgcatggcc gagttgagcg gttcccggct
ggccgcgcag caacagatgg aaggcctcct 4560ggcgccgcac cggcccaagg
agcccgcgtg gttcctggcc accgtcggcg tctcgcccga 4620ccaccagggc
aagggtctgg gcagcgccgt cgtgctcccc ggagtggagg cggccgagcg
4680cgccggggtg cccgccttcc tggagacctc cgcgccccgc aacctcccct
tctacgagcg 4740gctcggcttc accgtcaccg ccgacgtcga gtgcccgaag
gaccgcgcga cctggtgcat 4800gacccgcaag cccggtgcct gacggatcca
tcgctccggt gcccgtcagt gggcagagcg 4860cacatcgccc acagtccccg
agaagttggg gggaggggtc ggcaattgaa ccggtgccta 4920gagaaggtgg
cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc
4980cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc
tttttcgcaa 5040cgggtttgcc gccagaacac agctgcggcc gcgccgccac
catgtctcgc tccgtggcct 5100tagctgtgct cgcgctactc tctctttctg
gcctggaggc tatccagcgt actccaaaga 5160ttcaggttta ctcacgtcat
ccagcagaga atggaaagtc aaatttcctg aattgctatg 5220tgtctgggtt
tcatccatcc gacattgaag ttgacttact gaagaatgga gagagaattg
5280aaaaagtgga gcattcagac ttgtctttca gcaaggactg gtctttctat
ctcttgtact 5340acactgaatt cacccccact gaaaaagatg agtatgcctg
ccgtgtgaac catgtgactt 5400tgtcacagcc caagatagtt aagtgggatc
gagacatggg cggaggcgga agcgggggcg 5460gcggatccgg cggaggcgga
agcggcggcg ggggaagcgg ctctcactcc atgaggtatt 5520tcttcacatc
cgtgtcccgg cccggccgcg gggagccccg cttcatcgca gtgggctacg
5580tggacgacac gcagttcgtg cggttcgaca gcgacgccgc gagccagagg
atggagccgc 5640gggcgccgtg gatagagcag gagggtccgg agtattggga
cggggagaca cggaaagtga 5700aggcccactc acagactcac cgagtggacc
tggggaccct gcgcggctac tacaaccaga 5760gcgaggccgg ttctcacacc
gtccagagga tgtatggctg cgacgtgggg tcggactggc 5820gcttcctccg
cgggtaccac cagtacgcct acgacggcaa ggattacatc gccctgaaag
5880aggacctgcg ctcttggacc gcggcggaca tggcagctca gaccaccaag
cacaagtggg 5940aggcggccca tgtggcggag cagttgagag cctacctgga
gggcacgtgc gtggagtggc 6000tccgcagata cctggagaac gggaaggaga
cgctgcagcg cacggacgcc cccaaaacgc 6060atatgactca ccacgctgtc
tctgaccatg aagccaccct gaggtgctgg gccctgagct 6120tctaccctgc
ggagatcaca ctgacctggc agcgggatgg ggaggaccag acccaggaca
6180cggagctcgt ggagaccagg cctgcagggg atggaacctt ccagaagtgg
gcggctgtgg 6240tggtgccttc tggacaggag cagagataca cctgccatgt
gcagcatgag ggtttgccca 6300agcccctcac cctgagatgg gagccgtctt
cccagcccac catccccatc gtgggcatca 6360ttgctggcct ggttctcttt
ggagctgtga tcactggagc tgtggtcgct gctgtgatgt 6420ggaggaggaa
gagctcagat agaaaaggag ggagctactc tcaggctgca agcagtgaca
6480gtgcccaggg ctctgatgtg tctctcacag cttgtaaagt gtgagcggcc
gcgactctag 6540atcaggcgcg ccgttaccaa gcagctatgg aagcttatgg
acctcagaga ggaagtaacg 6600aggagagggt gtggtggaat gtcactagaa
accagggaaa acaaggagga gagtattaca 6660gggaaggagg tgaagaacct
cattacccaa atactcctgc tcctcataga cgtacctggg 6720atgagagaca
caaggttctt aaattgtcct cattcgctac tccctctgac atccaacgct
6780gggctactaa ctctagattg tacgggagct ctcttcacta ctcgctgcgt
cgagagtgta 6840cgagactctc caggtttggt aagaaatatt ttatattgtt
ataatgttac tatgatccat 6900taacactctg cttatagatt gtaagggtga
ttgcaatgct ttctgcataa aactttggtt 6960ttcttgttaa tcaataaacc
gacttgattc gagaacctac tcatatatta ttgtctcttt 7020tatactttat
taagtaaaag gatttgtata ttagccttgc taagggagac atctagtgat
7080ataagtgtga actacactta tcttaaatga tgtaactcct taggataatc
aatatacaaa 7140attccatgac aattggcgat accgtcgacc gttcagctgc
attaatgaat cggccaacgc 7200gcggggagag gcggtttgcg tattgggcgc
tcttccgctt cctcgctcac tgactcgctg 7260cgctcggtcg ttcggctgcg
gcgagcggta tcagctcact caaaggcggt aatacggtta 7320tccacagaat
caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc
7380aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc
ccctgacgag 7440catcacaaaa atcgacgctc aagtcagagg tggcgaaacc
cgacaggact ataaagatac 7500caggcgtttc cccctggaag ctccctcgtg
cgctctcctg ttccgaccct gccgcttacc 7560ggatacctgt ccgcctttct
cccttcggga agcgtggcgc tttctcaatg ctcacgctgt 7620aggtatctca
gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc
7680gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa
cccggtaaga 7740cacgacttat cgccactggc agcagccact ggtaacagga
ttagcagagc gaggtatgta 7800ggcggtgcta cagagttctt gaagtggtgg
cctaactacg gctacactag aaggacagta 7860tttggtatct gcgctctgct
gaagccagtt accttcggaa aaagagttgg tagctcttga 7920tccggcaaac
aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg
7980cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc
tgacgctcag 8040tggaacgaaa actcacgtta agggattttg gtcatgagat
tatcaaaaag gatcttcacc 8100tagatccttt taaattaaaa atgaagtttt
aaatcaatct aaagtatata tgagtaaact 8160tggtctgaca gttaccaatg
cttaatcagt gaggcaccta tctcagcgat ctgtctattt 8220cgttcatcca
tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta
8280ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc
tccagattta 8340tcagcaataa accagccagc cggaagggcc gagcgcagaa
gtggtcctgc aactttatcc 8400gcctccatcc agtctattaa ttgttgccgg
gaagctagag taagtagttc gccagttaat 8460agtttgcgca acgttgttgc
cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt 8520atggcttcat
tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg
8580tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa
gttggccgca 8640gtgttatcac tcatggttat ggcagcactg cataattctc
ttactgtcat gccatccgta 8700agatgctttt ctgtgactgg tgagtactca
accaagtcat tctgagaata gtgtatgcgg 8760cgaccgagtt gctcttgccc
ggcgtcaata cgggataata ccgcgccaca tagcagaact 8820ttaaaagtgc
tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg
8880ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc
agcatctttt 8940actttcacca gcgtttctgg gtgagcaaaa acaggaaggc
aaaatgccgc aaaaaaggga 9000ataagggcga cacggaaatg ttgaatactc
atactcttcc tttttcaata ttattgaagc 9060atttatcagg gttattgtct
catgagcgga tacatatttg aatgtattta gaaaaataaa 9120caaatagggg
ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt
9180attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tc
923216480PRTArtificial SequenceHLA-bBA0201 (human B2M-HLA-A0201
fusion peptide) 16Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu
Leu Ser Leu Ser 1 5 10 15 Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys
Ile Gln Val Tyr Ser Arg 20 25 30 His Pro Ala Glu Asn Gly Lys Ser
Asn Phe Leu Asn Cys Tyr Val Ser 35 40 45 Gly Phe His Pro Ser Asp
Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 50 55 60 Arg Ile Glu Lys
Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 65 70 75 80 Ser Phe
Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 85 90 95
Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 100
105 110 Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly
Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser
His Ser Met 130 135 140 Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly
Arg Gly Glu Pro Arg 145 150 155 160 Phe Ile Ala Val Gly Tyr Val Asp
Asp Thr Gln Phe Val Arg Phe Asp 165 170 175 Ser Asp Ala Ala Ser Gln
Arg Met Glu Pro Arg Ala Pro Trp Ile Glu 180 185 190 Gln Glu Gly Pro
Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala 195 200 205 His Ser
Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr 210 215 220
Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys 225
230 235 240 Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln
Tyr Ala 245 250 255 Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp
Leu Arg Ser Trp 260 265 270 Thr Ala Ala Asp Met Ala Ala Gln Thr Thr
Lys His Lys Trp Glu Ala 275 280 285 Ala His Val Ala Glu Gln Leu Arg
Ala Tyr Leu Glu Gly Thr Cys Val 290 295 300 Glu Trp Leu Arg Arg Tyr
Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg 305 310 315 320 Thr Asp Ala
Pro Lys Thr His Met Thr His His Ala Val Ser Asp His 325 330 335 Glu
Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile 340 345
350 Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu
355 360 365 Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys
Trp Ala 370 375 380 Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr
Thr Cys His Val 385 390 395 400 Gln His Glu Gly Leu Pro Lys Pro Leu
Thr Leu Arg Trp Glu Pro Ser 405 410 415 Ser Gln Pro Thr Ile Pro Ile
Val Gly Ile Ile Ala Gly Leu Val Leu 420 425 430 Phe Gly Ala Val Ile
Thr Gly Ala Val Val Ala Ala Val Met Trp Arg 435 440 445 Arg Lys Ser
Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser 450 455 460 Ser
Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 465 470
475 480 179224DNAArtificial SequenceVector sequence for HLA-gBE
17ctcgaggagc ttggcccatt gcatacgttg tatccatatc ataatatgta catttatatt
60ggctcatgtc caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa
120tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac
ataacttacg 180gtaaatggcc cgcctggctg accgcccaac gacccccgcc
cattgacgtc aataatgacg 240tatgttccca tagtaacgcc aatagggact
ttccattgac gtcaatgggt ggagtattta 300cgctaaactg cccacttggc
agtacatcaa gtgtatcata tgccaagtac gccccctatt 360gacgtcaatg
acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac
420tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt
gatgcggttt 480tggcagtaca tcaatgggcg tggatagcgg tttgactcac
ggggatttcc aagtctccac 540cccattgacg tcaatgggag tttgttttgg
caccaaaatc aacgggactt tccaaaatgt 600cgtaacaact ccgccccatt
gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat 660ataagcagag
cttctagatt gtacgggagc tcttcactac tcgctgcgtc gagagtgtac
720gagactctcc aggtttggta agaaatattt tatattgtta taatgttact
atgatccatt 780aacactctgc ttatagattg taagggtgat tgcaatgctt
tctgcataaa actttggttt 840tcttgttaat caataaaccg acttgattcg
agaacctact catatattat tgtctctttt 900atactttatt aagtaaaagg
atttgtatat tagccttgct aagggagaca tctagtgata 960taagtgtgaa
ctacacttat cttaaatgat gtaactcctt aggataatca atatacaaaa
1020ttccatgaca attggcgccc aacgtggggc tcgaatataa gtcgggttta
tttgtaaatt 1080atccctaggg acctccgagc atagcgggag gcatataaaa
gccaatagac aatggctagc 1140aggaagtaat gttgaagaat atgaacttga
tgttgaagct ctggttgtaa ttttaagaga 1200tagaaatata ccaagaaatc
ctttacatgg agaagttata ggtcttcgcc ttactgaagg 1260atggtgggga
caaattgaga gatttcagat ggtacgttga tctaaggcta tggatttggc
1320catgggacaa gaaatattag tttatagtcc cattgtatct atgactaaaa
tacaaaaaac 1380tccactacca gaaagaaaag ctttacccat tagatggata
acatggatga cttatttaga 1440agatccaaga atccaatttc attatgataa
aaccttacca gaacttaagc atattccaga 1500tgtatataca tctagtcagt
ctcctgttaa acatccttct caatatgaag gagtgtttta 1560tactgatggc
tcggccatca aaagtcctga tcctacaaaa agcaataatg ctggcatggg
1620aatagtacat gccacataca aacctgaata tcaagttttg aatcaatggt
caataccact 1680aggtaatcat actgctcaga tggctgaaat agctgcagtt
gaatttgcct gtaaaaaagc 1740tttaaaaata cctggtcctg tattagttat
aactgatagt ttctatgtag cagaaagtgc 1800taataaagaa ttaccatact
ggaaatctaa tgggtttgtt aataataaga aaaagcctct 1860taaacatatc
tccaaatgga aatctattgc tgagtgttta tctatgaaac cagacattac
1920tattcaacat gaaaaaggca tcagcctaca aataccagta ttcatactga
aaggcaatgc 1980cctagcagat aagcttgcca cccaaggaag ttatgtggtt
aattgtaata ccaaaaaacc 2040aaacctggat gcagagttgg atcaattatt
acagggtcat tatataaaag gatatcccaa 2100acaatataca tattttttag
aagatggcaa agtaaaagtt tccagacctg aaggggttaa 2160aattattccc
cctcagtcag acagacaaaa aattgtgctt caagcccaca atttggctca
2220caccggacgt gaagccactc ttttaaaaat tgccaacctt tattggtggc
caaatatgag 2280aaaggatgtg gttaaacaac taggacgctg tcaacagtgt
ttaatcacaa atgcttccaa 2340caaagcctct ggtcctattc taagaccaga
taggcctcaa aaaccttttg ataaattctt 2400tattgactat attggacctt
tgccaccttc acagggatac ctatatgtat tagtagttgt 2460tgatggaatg
acaggattca cttggttata ccccactaag gctccttcta ctagcgcaac
2520tgttaaatct ctcaatgtac tcactagtat tgcaattcca aaggtgattc
actctgatca 2580aggtgcagca ttcacttctt caacctttgc tgaatgggca
aaggaaagag gtatacattt 2640ggaattcagt actccttatc acccccaaag
tggtagtaag gtggaaagga aaaatagtga 2700tataaaacga cttttaacta
aactgctagt aggaagaccc acaaagtggt atgacctatt 2760gcctgttgta
caacttgctt taaacaacac ctatagccct gtattaaaat atactccaca
2820tcaactctta tttggtatag attcaaatac tccatttgca aatcaagata
cacttgactt 2880gaccagagaa gaagaacttt ctcttttaca ggaaattcgt
acttctttat accatccatc 2940cacccctcca gcctcctctc gttcctggtc
tcctgttgtt ggccaattgg tccaggagag 3000ggtggctagg cctgcttctt
tgagacctcg ttggcataaa ccgtctactg tacttaaggt 3060gttgaatcca
aggactgttg ttattttgga ccatcttggc aacaacagaa ctgtaagtat
3120agataattta aaacctactt ctcatcagaa tggcaccacc aatgacactg
caacaatgga 3180tcatttggaa aaaaatgaat aaagcgcatg aggcacttca
aaatacaaca actgtgactg 3240aacagcagaa ggaacaaatt atactggaca
ttcaaaatga agaagtacaa ccaactagga 3300gagataaatt tagatatctg
ctttatactt gttgtgctac tagctcaaga gtattggcct 3360ggatgttttt
agtttgtata ttgttaatca ttgttttggt ttcatgcttt gtgactatat
3420ccagaataca atggaataag gatattcagg tattaggacc tgtaatagac
tggaatgtta 3480ctcaaagagc tgtttatcaa cccttacaga ctagaaggat
tgcacgttcc cttagaatgc 3540agcatcctgt tccaaaatat gtggaggtaa
atatgactag tattccacaa ggtgtatact 3600atgaacccca tccggcctcg
acggtatcga tggtaccggt atcgataagc ttgataacct 3660cgagagatct
aattctaccg ggtaggggag gcgcttttcc caaggcagtc tggagcatgc
3720gctttagcag ccccgctggc acttggcgct acacaagtgg cctctggcct
cgcacacatt 3780ccacatccac cggtagcgcc aaccggctcc gttctttggt
ggccccttcg cgccacttct 3840actcctcccc tagtcaggaa gtttccccca
gcaagctcgc gtcgtgcagg acgtgacaaa 3900tggaagtagc acgtctcact
agtctcgtgc agatggacag caccgctgag caatggaagc 3960gggtaggcct
ttggggcagc ggccaatagc agctttgttc cttcgctttc tgggctcaga
4020ggctgggaag gggtgggtcc gggggcgggc tcaggggcgg gctcaggggc
gggcgggcgc 4080ccgaaggtcc tcccgaggcc cggcattctg cacgcttcaa
aagcgcacgt ctgccgcgct 4140gttctcctct tcctcatctc cgggcctttc
gacctgcagc ccgggggatc gatcctaggt 4200gatttaaatc caccatgacc
gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg 4260tcccccgggc
cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca
4320ccgtcgaccc ggaccgccac atcgagcggg tcaccgagct gcaagaactc
ttcctcacgc 4380gcgtcgggct cgacatcggc aaggtgtggg tcgcggacga
cggcgccgcg gtggcggtct 4440ggaccacgcc ggagagcgtc gaagcggggg
cggtgttcgc cgagatcggc ccgcgcatgg 4500ccgagttgag cggttcccgg
ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc 4560accggcccaa
ggagcccgcg tggttcctgg ccaccgtcgg cgtctcgccc gaccaccagg
4620gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag
cgcgccgggg 4680tgcccgcctt cctggagacc tccgcgcccc gcaacctccc
cttctacgag cggctcggct 4740tcaccgtcac cgccgacgtc gagtgcccga
aggaccgcgc gacctggtgc atgacccgca 4800agcccggtgc ctgacggatc
catcgctccg gtgcccgtca gtgggcagag cgcacatcgc 4860ccacagtccc
cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt
4920ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt
cccgagggtg 4980ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt
tctttttcgc aacgggtttg 5040ccgccagaac acagctgcgg ccgcgttaac
catggtggtc atggcccctc gaactctgtt 5100cctgctgctg agtggggctc
tgaccctgac agagtccgga atccagcgga cccccaagat 5160tcaggtgtac
agcagacacc ctgcagagaa cggcaaatcc aacttcctga attgctatgt
5220gtctgggttt catcccagtg acatcgaagt cgatctgctg aagaatggcg
agagaattga 5280aaaagtcgag cactctgacc tgagcttctc caaggattgg
tccttttacc tgctgtacta 5340taccgagttt actccaaccg aaaaagacga
gtatgcctgt agggtgaacc atgtcacact 5400gagccagccc aagatcgtga
aatgggaccg cgatatgggc gggggaggct cagggggagg 5460cgggagcgga
ggcgggggct ccggcggggg aggatccggt tctcactcct tgaagtattt
5520ccacacttcc gtgtcccggc ccggccgcgg ggagccccgc ttcatctctg
tgggctacgt
5580ggacgacacc cagttcgtgc gcttcgacaa cgacgccgcg agtccgagga
tggtgccgcg 5640ggcgccgtgg atggagcagg aggggtcaga gtattgggac
cgggagacac ggagcgccag 5700ggacaccgca cagattttcc gagtgaatct
gcggacgctg cgcggctact acaatcagag 5760cgaggccggg tctcacaccc
tgcagtggat gcatggctgc gagctggggc ccgacgggcg 5820cttcctccgc
gggtatgaac agttcgccta cgacggcaag gattatctca ccctgaatga
5880ggacctgcgc tcctggaccg cggtggacac ggcggctcag atctccgagc
aaaagtcaaa 5940tgatgcctct gaggcggagc accagagagc ctacctggaa
gacacatgcg tggagtggct 6000ccacaaatac ctggagaagg ggaaggagac
gctgcttcac ctggagcccc caaagacaca 6060cgtgactcac caccccatct
ctgaccatga ggccaccctg aggtgctggg ccctgggctt 6120ctaccctgcg
gagatcacac tgacctggca gcaggatggg gagggccata cccaggacac
6180ggagctcgtg gagaccaggc ctgcagggga tggaaccttc cagaagtggg
cagctgtggt 6240ggtgccttct ggagaggagc agagatacac gtgccatgtg
cagcatgagg ggctacccga 6300gcccgtcacc ctgagatgga agccggcttc
ccagcccacc atccccatcg tgggcatcat 6360tgctggcctg gttctccttg
gatctgtggt ctctggagct gtggttgctg ctgtgatatg 6420gaggaagaag
agctcaggtg gaaaaggagg gagctactct aaggctgagt ggagcgacag
6480tgcccagggg tctgagtctc acagcttgta atctagagcg gccgcgactc
tagatcaggc 6540gcgccgttac caagcagcta tggaagctta tggacctcag
agaggaagta acgaggagag 6600ggtgtggtgg aatgtcacta gaaaccaggg
aaaacaagga ggagagtatt acagggaagg 6660aggtgaagaa cctcattacc
caaatactcc tgctcctcat agacgtacct gggatgagag 6720acacaaggtt
cttaaattgt cctcattcgc tactccctct gacatccaac gctggactac
6780taactctaga ttgtacggga ggctcttcac tactcgctgc gtcgagagtg
tacgagactc 6840tccaggtttg gtaagaaata ttttatattg ttataatgtt
actatgatcc attaacactc 6900tgcttataga ttgtaagggt gattgcaatg
ctttctgcat aaaactttgg ttttcttgtt 6960aatcaataaa ccgacttgat
tcgagaacca actcctatat tattgtctct tttatacttt 7020attaagtaaa
aggatttgta tattagcctt gctaagggag acatctagtg atataagtgt
7080gaactacact tatcttaaat gatgtaactc cttaggataa tcaatataca
aaattccatg 7140acaattggcg ataccgtcga ccgttcagct gcattaatga
atcggccaac gcgcggggag 7200aggcggtttg cgtattgggc gctcttccgc
ttcctcgctc actgactcgc tgcgctcggt 7260cgttcggctg cggcgagcgg
tatcagctca ctcaaaggcg gtaatacggt tatccacaga 7320atcaggggat
aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg
7380taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg
agcatcacaa 7440aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga
ctataaagat accaggcgtt 7500tccccctgga agctccctcg tgcgctctcc
tgttccgacc ctgccgctta ccggatacct 7560gtccgccttt ctcccttcgg
gaagcgtggc gctttctcaa tgctcacgct gtaggtatct 7620cagttcggtg
taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc
7680cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa
gacacgactt 7740atcgccactg gcagcagcca ctggtaacag gattagcaga
gcgaggtatg taggcggtgc 7800tacagagttc ttgaagtggt ggcctaacta
cggctacact agaaggacag tatttggtat 7860ctgcgctctg ctgaagccag
ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa 7920acaaaccacc
gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa
7980aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc
agtggaacga 8040aaactcacgt taagggattt tggtcatgag attatcaaaa
aggatcttca cctagatcct 8100tttaaattaa aaatgaagtt ttaaatcaat
ctaaagtata tatgagtaaa cttggtctga 8160cagttaccaa tgcttaatca
gtgaggcacc tatctcagcg atctgtctat ttcgttcatc 8220catagttgcc
tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg
8280ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt
tatcagcaat 8340aaaccagcca gccggaaggg ccgagcgcag aagtggtcct
gcaactttat ccgcctccat 8400ccagtctatt aattgttgcc gggaagctag
agtaagtagt tcgccagtta atagtttgcg 8460caacgttgtt gccattgcta
caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc 8520attcagctcc
ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa
8580agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg
cagtgttatc 8640actcatggtt atggcagcac tgcataattc tcttactgtc
atgccatccg taagatgctt 8700ttctgtgact ggtgagtact caaccaagtc
attctgagaa tagtgtatgc ggcgaccgag 8760ttgctcttgc ccggcgtcaa
tacgggataa taccgcgcca catagcagaa ctttaaaagt 8820gctcatcatt
ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag
8880atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt
ttactttcac 8940cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc
gcaaaaaagg gaataagggc 9000gacacggaaa tgttgaatac tcatactctt
cctttttcaa tattattgaa gcatttatca 9060gggttattgt ctcatgagcg
gatacatatt tgaatgtatt tagaaaaata aacaaatagg 9120ggttccgcgc
acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat
9180gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtc
922418476PRTArtificial SequenceHLA-gBE 18Met Ala Pro Arg Thr Leu
Phe Leu Leu Leu Ser Gly Ala Leu Thr Leu 1 5 10 15 Thr Glu Ser Gly
Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 20 25 30 His Pro
Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 35 40 45
Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 50
55 60 Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp
Trp 65 70 75 80 Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr
Glu Lys Asp 85 90 95 Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu
Ser Gln Pro Lys Ile 100 105 110 Val Lys Trp Asp Arg Asp Met Gly Gly
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Ser His Ser Leu 130 135 140 Lys Tyr Phe His Thr
Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg 145 150 155 160 Phe Ile
Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp 165 170 175
Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu 180
185 190 Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg
Asp 195 200 205 Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg
Gly Tyr Tyr 210 215 220 Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln
Trp Met His Gly Cys 225 230 235 240 Glu Leu Gly Pro Asp Gly Arg Phe
Leu Arg Gly Tyr Glu Gln Phe Ala 245 250 255 Tyr Asp Gly Lys Asp Tyr
Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp 260 265 270 Thr Ala Val Asp
Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp 275 280 285 Ala Ser
Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val 290 295 300
Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His 305
310 315 320 Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile Ser
Asp His 325 330 335 Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr
Pro Ala Glu Ile 340 345 350 Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly
His Thr Gln Asp Thr Glu 355 360 365 Leu Val Glu Thr Arg Pro Ala Gly
Asp Gly Thr Phe Gln Lys Trp Ala 370 375 380 Ala Val Val Val Pro Ser
Gly Glu Glu Gln Arg Tyr Thr Cys His Val 385 390 395 400 Gln His Glu
Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala 405 410 415 Ser
Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu 420 425
430 Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg
435 440 445 Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala
Glu Trp 450 455 460 Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu
465 470 475 199287DNAArtificial SequenceVector sequence for
HLA-bGBE 19ctcgaggagc ttggcccatt gcatacgttg tatccatatc ataatatgta
catttatatt 60ggctcatgtc caacattacc gccatgttga cattgattat tgactagtta
ttaatagtaa 120tcaattacgg ggtcattagt tcatagccca tatatggagt
tccgcgttac ataacttacg 180gtaaatggcc cgcctggctg accgcccaac
gacccccgcc cattgacgtc aataatgacg 240tatgttccca tagtaacgcc
aatagggact ttccattgac gtcaatgggt ggagtattta 300cgctaaactg
cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt
360gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac
cttatgggac 420tttcctactt ggcagtacat ctacgtatta gtcatcgcta
ttaccatggt gatgcggttt 480tggcagtaca tcaatgggcg tggatagcgg
tttgactcac ggggatttcc aagtctccac 540cccattgacg tcaatgggag
tttgttttgg caccaaaatc aacgggactt tccaaaatgt 600cgtaacaact
ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat
660ataagcagag cttctagatt gtacgggagc tcttcactac tcgctgcgtc
gagagtgtac 720gagactctcc aggtttggta agaaatattt tatattgtta
taatgttact atgatccatt 780aacactctgc ttatagattg taagggtgat
tgcaatgctt tctgcataaa actttggttt 840tcttgttaat caataaaccg
acttgattcg agaacctact catatattat tgtctctttt 900atactttatt
aagtaaaagg atttgtatat tagccttgct aagggagaca tctagtgata
960taagtgtgaa ctacacttat cttaaatgat gtaactcctt aggataatca
atatacaaaa 1020ttccatgaca attggcgccc aacgtggggc tcgaatataa
gtcgggttta tttgtaaatt 1080atccctaggg acctccgagc atagcgggag
gcatataaaa gccaatagac aatggctagc 1140aggaagtaat gttgaagaat
atgaacttga tgttgaagct ctggttgtaa ttttaagaga 1200tagaaatata
ccaagaaatc ctttacatgg agaagttata ggtcttcgcc ttactgaagg
1260atggtgggga caaattgaga gatttcagat ggtacgttga tctaaggcta
tggatttggc 1320catgggacaa gaaatattag tttatagtcc cattgtatct
atgactaaaa tacaaaaaac 1380tccactacca gaaagaaaag ctttacccat
tagatggata acatggatga cttatttaga 1440agatccaaga atccaatttc
attatgataa aaccttacca gaacttaagc atattccaga 1500tgtatataca
tctagtcagt ctcctgttaa acatccttct caatatgaag gagtgtttta
1560tactgatggc tcggccatca aaagtcctga tcctacaaaa agcaataatg
ctggcatggg 1620aatagtacat gccacataca aacctgaata tcaagttttg
aatcaatggt caataccact 1680aggtaatcat actgctcaga tggctgaaat
agctgcagtt gaatttgcct gtaaaaaagc 1740tttaaaaata cctggtcctg
tattagttat aactgatagt ttctatgtag cagaaagtgc 1800taataaagaa
ttaccatact ggaaatctaa tgggtttgtt aataataaga aaaagcctct
1860taaacatatc tccaaatgga aatctattgc tgagtgttta tctatgaaac
cagacattac 1920tattcaacat gaaaaaggca tcagcctaca aataccagta
ttcatactga aaggcaatgc 1980cctagcagat aagcttgcca cccaaggaag
ttatgtggtt aattgtaata ccaaaaaacc 2040aaacctggat gcagagttgg
atcaattatt acagggtcat tatataaaag gatatcccaa 2100acaatataca
tattttttag aagatggcaa agtaaaagtt tccagacctg aaggggttaa
2160aattattccc cctcagtcag acagacaaaa aattgtgctt caagcccaca
atttggctca 2220caccggacgt gaagccactc ttttaaaaat tgccaacctt
tattggtggc caaatatgag 2280aaaggatgtg gttaaacaac taggacgctg
tcaacagtgt ttaatcacaa atgcttccaa 2340caaagcctct ggtcctattc
taagaccaga taggcctcaa aaaccttttg ataaattctt 2400tattgactat
attggacctt tgccaccttc acagggatac ctatatgtat tagtagttgt
2460tgatggaatg acaggattca cttggttata ccccactaag gctccttcta
ctagcgcaac 2520tgttaaatct ctcaatgtac tcactagtat tgcaattcca
aaggtgattc actctgatca 2580aggtgcagca ttcacttctt caacctttgc
tgaatgggca aaggaaagag gtatacattt 2640ggaattcagt actccttatc
acccccaaag tggtagtaag gtggaaagga aaaatagtga 2700tataaaacga
cttttaacta aactgctagt aggaagaccc acaaagtggt atgacctatt
2760gcctgttgta caacttgctt taaacaacac ctatagccct gtattaaaat
atactccaca 2820tcaactctta tttggtatag attcaaatac tccatttgca
aatcaagata cacttgactt 2880gaccagagaa gaagaacttt ctcttttaca
ggaaattcgt acttctttat accatccatc 2940cacccctcca gcctcctctc
gttcctggtc tcctgttgtt ggccaattgg tccaggagag 3000ggtggctagg
cctgcttctt tgagacctcg ttggcataaa ccgtctactg tacttaaggt
3060gttgaatcca aggactgttg ttattttgga ccatcttggc aacaacagaa
ctgtaagtat 3120agataattta aaacctactt ctcatcagaa tggcaccacc
aatgacactg caacaatgga 3180tcatttggaa aaaaatgaat aaagcgcatg
aggcacttca aaatacaaca actgtgactg 3240aacagcagaa ggaacaaatt
atactggaca ttcaaaatga agaagtacaa ccaactagga 3300gagataaatt
tagatatctg ctttatactt gttgtgctac tagctcaaga gtattggcct
3360ggatgttttt agtttgtata ttgttaatca ttgttttggt ttcatgcttt
gtgactatat 3420ccagaataca atggaataag gatattcagg tattaggacc
tgtaatagac tggaatgtta 3480ctcaaagagc tgtttatcaa cccttacaga
ctagaaggat tgcacgttcc cttagaatgc 3540agcatcctgt tccaaaatat
gtggaggtaa atatgactag tattccacaa ggtgtatact 3600atgaacccca
tccggcctcg acggtatcga tggtaccggt atcgataagc ttgataacct
3660cgagagatct aattctaccg ggtaggggag gcgcttttcc caaggcagtc
tggagcatgc 3720gctttagcag ccccgctggc acttggcgct acacaagtgg
cctctggcct cgcacacatt 3780ccacatccac cggtagcgcc aaccggctcc
gttctttggt ggccccttcg cgccacttct 3840actcctcccc tagtcaggaa
gtttccccca gcaagctcgc gtcgtgcagg acgtgacaaa 3900tggaagtagc
acgtctcact agtctcgtgc agatggacag caccgctgag caatggaagc
3960gggtaggcct ttggggcagc ggccaatagc agctttgttc cttcgctttc
tgggctcaga 4020ggctgggaag gggtgggtcc gggggcgggc tcaggggcgg
gctcaggggc gggcgggcgc 4080ccgaaggtcc tcccgaggcc cggcattctg
cacgcttcaa aagcgcacgt ctgccgcgct 4140gttctcctct tcctcatctc
cgggcctttc gacctgcagc ccgggggatc gatcctaggt 4200gatttaaatc
caccatgacc gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg
4260tcccccgggc cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc
acgcgccaca 4320ccgtcgaccc ggaccgccac atcgagcggg tcaccgagct
gcaagaactc ttcctcacgc 4380gcgtcgggct cgacatcggc aaggtgtggg
tcgcggacga cggcgccgcg gtggcggtct 4440ggaccacgcc ggagagcgtc
gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg 4500ccgagttgag
cggttcccgg ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc
4560accggcccaa ggagcccgcg tggttcctgg ccaccgtcgg cgtctcgccc
gaccaccagg 4620gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga
ggcggccgag cgcgccgggg 4680tgcccgcctt cctggagacc tccgcgcccc
gcaacctccc cttctacgag cggctcggct 4740tcaccgtcac cgccgacgtc
gagtgcccga aggaccgcgc gacctggtgc atgacccgca 4800agcccggtgc
ctgacggatc catcgctccg gtgcccgtca gtgggcagag cgcacatcgc
4860ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc
tagagaaggt 4920ggcgcggggt aaactgggaa agtgatgtcg tgtactggct
ccgccttttt cccgagggtg 4980ggggagaacc gtatataagt gcagtagtcg
ccgtgaacgt tctttttcgc aacgggtttg 5040ccgccagaac acagctgcgg
ccgcgttaac catgagccga tccgtggcac tggctgtcct 5100ggctctgctg
tctctgagtg gcctggaagc agtgatggcc cctagaacac tgttcctggg
5160cggaggcggc tccggaggag gagggtctgg aggcggggga agtatccagc
ggactcccaa 5220gattcaggtc tacagcagac accctgccga aaacgggaaa
tccaacttcc tgaattgcta 5280tgtgtcaggc tttcatccca gcgacatcga
ggtcgatctg ctgaagaatg gcgagcggat 5340tgaaaaagtg gagcactctg
acctgtcatt cagcaaggat tggagctttt acctgctgta 5400ctatactgag
tttaccccaa cagaaaaaga cgagtatgcc tgtagggtga accatgtcac
5460cctgagtcag cccaagatcg tgaaatggga ccgcgatatg ggcgggggag
gctccggggg 5520aggcggctcc ggcggcgggg gaagtggcgg gggaggatcc
ggttctcact ccttgaagta 5580tttccacact tccgtgtccc ggcccggccg
cggggagccc cgcttcatct ctgtgggcta 5640cgtggacgac acccagttcg
tgcgcttcga caacgacgcc gcgagtccga ggatggtgcc 5700gcgggcgccg
tggatggagc aggaggggtc agagtattgg gaccgggaga cacggagcgc
5760cagggacacc gcacagattt tccgagtgaa tctgcggacg ctgcgcggct
actacaatca 5820gagcgaggcc gggtctcaca ccctgcagtg gatgcatggc
tgcgagctgg ggcccgacgg 5880gcgcttcctc cgcgggtatg aacagttcgc
ctacgacggc aaggattatc tcaccctgaa 5940tgaggacctg cgctcctgga
ccgcggtgga cacggcggct cagatctccg agcaaaagtc 6000aaatgatgcc
tctgaggcgg agcaccagag agcctacctg gaagacacat gcgtggagtg
6060gctccacaaa tacctggaga aggggaagga gacgctgctt cacctggagc
ccccaaagac 6120acacgtgact caccacccca tctctgacca tgaggccacc
ctgaggtgct gggccctggg 6180cttctaccct gcggagatca cactgacctg
gcagcaggat ggggagggcc atacccagga 6240cacggagctc gtggagacca
ggcctgcagg ggatggaacc ttccagaagt gggcagctgt 6300ggtggtgcct
tctggagagg agcagagata cacgtgccat gtgcagcatg aggggctacc
6360cgagcccgtc accctgagat ggaagccggc ttcccagccc accatcccca
tcgtgggcat 6420cattgctggc ctggttctcc ttggatctgt ggtctctgga
gctgtggttg ctgctgtgat 6480atggaggaag aagagctcag gtggaaaagg
agggagctac tctaaggctg agtggagcga 6540cagtgcccag gggtctgagt
ctcacagctt gtaatctaga gcggccgcga ctctagatca 6600ggcgcgccgt
taccaagcag ctatggaagc ttatggacct cagagaggaa gtaacgagga
6660gagggtgtgg tggaatgtca ctagaaacca gggaaaacaa ggaggagagt
attacaggga 6720aggaggtgaa gaacctcatt acccaaatac tcctgctcct
catagacgta cctgggatga 6780gagacacaag gttcttaaat tgtcctcatt
cgctactccc tctgacatcc aacgctggac 6840tactaactct agattgtacg
ggaggctctt cactactcgc tgcgtcgaga gtgtacgaga 6900ctctccaggt
ttggtaagaa atattttata ttgttataat gttactatga tccattaaca
6960ctctgcttat agattgtaag ggtgattgca atgctttctg cataaaactt
tggttttctt 7020gttaatcaat aaaccgactt gattcgagaa ccaactccta
tattattgtc tcttttatac 7080tttattaagt aaaaggattt gtatattagc
cttgctaagg gagacatcta gtgatataag 7140tgtgaactac acttatctta
aatgatgtaa ctccttagga taatcaatat acaaaattcc 7200atgacaattg
gcgataccgt cgaccgttca gctgcattaa tgaatcggcc aacgcgcggg
7260gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact
cgctgcgctc 7320ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag
gcggtaatac ggttatccac 7380agaatcaggg gataacgcag gaaagaacat
gtgagcaaaa ggccagcaaa aggccaggaa 7440ccgtaaaaag gccgcgttgc
tggcgttttt ccataggctc cgcccccctg acgagcatca 7500caaaaatcga
cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc
7560gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc
ttaccggata 7620cctgtccgcc tttctccctt cgggaagcgt ggcgctttct
caatgctcac gctgtaggta 7680tctcagttcg gtgtaggtcg ttcgctccaa
gctgggctgt gtgcacgaac cccccgttca 7740gcccgaccgc tgcgccttat
ccggtaacta tcgtcttgag tccaacccgg taagacacga 7800cttatcgcca
ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg
7860tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga
cagtatttgg 7920tatctgcgct ctgctgaagc cagttacctt cggaaaaaga
gttggtagct cttgatccgg 7980caaacaaacc accgctggta gcggtggttt
ttttgtttgc aagcagcaga ttacgcgcag 8040aaaaaaagga tctcaagaag
atcctttgat cttttctacg gggtctgacg ctcagtggaa 8100cgaaaactca
cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat
8160ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt
aaacttggtc 8220tgacagttac caatgcttaa tcagtgaggc acctatctca
gcgatctgtc tatttcgttc 8280atccatagtt gcctgactcc ccgtcgtgta
gataactacg atacgggagg gcttaccatc 8340tggccccagt gctgcaatga
taccgcgaga cccacgctca ccggctccag atttatcagc 8400aataaaccag
ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc
8460catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag
ttaatagttt 8520gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca
cgctcgtcgt ttggtatggc 8580ttcattcagc tccggttccc aacgatcaag
gcgagttaca tgatccccca tgttgtgcaa 8640aaaagcggtt agctccttcg
gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt 8700atcactcatg
gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg
8760cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta
tgcggcgacc 8820gagttgctct tgcccggcgt caatacggga taataccgcg
ccacatagca gaactttaaa 8880agtgctcatc attggaaaac gttcttcggg
gcgaaaactc tcaaggatct taccgctgtt 8940gagatccagt tcgatgtaac
ccactcgtgc acccaactga tcttcagcat cttttacttt 9000caccagcgtt
tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag
9060ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt
gaagcattta 9120tcagggttat tgtctcatga gcggatacat atttgaatgt
atttagaaaa ataaacaaat 9180aggggttccg cgcacatttc cccgaaaagt
gccacctgac gtctaagaaa ccattattat 9240catgacatta acctataaaa
ataggcgtat cacgaggccc tttcgtc 928720500PRTArtificial
SequenceHLA-bGBE 20Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu
Leu Ser Leu Ser 1 5 10 15 Gly Leu Glu Ala Val Met Ala Pro Arg Thr
Leu Phe Leu Gly Gly Gly 20 25 30 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ile Gln Arg Thr 35 40 45 Pro Lys Ile Gln Val Tyr
Ser Arg His Pro Ala Glu Asn Gly Lys Ser 50 55 60 Asn Phe Leu Asn
Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 65 70 75 80 Val Asp
Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 85 90 95
Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 100
105 110 Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn
His 115 120 125 Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg
Asp Met Gly 130 135 140 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 145 150 155 160 Gly Gly Ser Gly Ser His Ser Leu
Lys Tyr Phe His Thr Ser Val Ser 165 170 175 Arg Pro Gly Arg Gly Glu
Pro Arg Phe Ile Ser Val Gly Tyr Val Asp 180 185 190 Asp Thr Gln Phe
Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met 195 200 205 Val Pro
Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp 210 215 220
Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn 225
230 235 240 Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly
Ser His 245 250 255 Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro
Asp Gly Arg Phe 260 265 270 Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp
Gly Lys Asp Tyr Leu Thr 275 280 285 Leu Asn Glu Asp Leu Arg Ser Trp
Thr Ala Val Asp Thr Ala Ala Gln 290 295 300 Ile Ser Glu Gln Lys Ser
Asn Asp Ala Ser Glu Ala Glu His Gln Arg 305 310 315 320 Ala Tyr Leu
Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu 325 330 335 Lys
Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val 340 345
350 Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala
355 360 365 Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln
Asp Gly 370 375 380 Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr
Arg Pro Ala Gly 385 390 395 400 Asp Gly Thr Phe Gln Lys Trp Ala Ala
Val Val Val Pro Ser Gly Glu 405 410 415 Glu Gln Arg Tyr Thr Cys His
Val Gln His Glu Gly Leu Pro Glu Pro 420 425 430 Val Thr Leu Arg Trp
Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val 435 440 445 Gly Ile Ile
Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala 450 455 460 Val
Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly 465 470
475 480 Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser
Glu 485 490 495 Ser His Ser Leu 500 217159DNAArtificial
SequenceVector sequence for pA2-B2METKNpA 21ctgcgcgctc gctcgctcac
tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60ggtcgcccgg cctcagtgag
cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120aggggttcct
gcggccgcga tgcagtccaa actctcacta aaattgccga gccctttgtc
180ttccagtgtc taaaatatta atgtcaatgg aatcaggcca gagtttgaat
tctagtctct 240tagcctttgt ttcccctgtc cataaaatga atgggggtaa
ttctttcctc ctacagttta 300tttatatatt cactaattca ttcattcatc
catccattcg ttcattcggt ttactgagta 360cctactatgt gccagcccct
gttctagggt ggaaactaag agaatgatgt acctagaggg 420cgctggaagc
tctaaagccc tagcagttac tgcttttact attagtggtc gtttttttct
480cccccccgcc ccccgacaaa tcaacagaac aaagaaaatt acctaaacag
caaggacata 540gggaggaact tcttggcaca gaactttcca aacacttttt
cctgaaggga tacaagaagc 600aagaaaggta ctctttcact aggaccttct
ctgagctgtc ctcaggatgc ttttgggact 660atttttctta cccagagaat
ggagaaaccc tgcagggaat tcccaagctg tagttataaa 720cagaagttct
ccttctgcta ggtagcattc aaagatctta atcttctggg tttccgtttt
780ctcgaatgaa aaatgcaggt ccgagcagtt aactggctgg ggcaccatta
gcaagtcact 840tagcatctct ggggccagtc tgcaaagcga gggggcagcc
ttaatgtgcc tccagcctga 900agtcctagaa tgagcgcccg gtgtcccaag
ctggggcgcg caccccagat cggagggcgc 960cgatgtacag acagcaaact
cacccagtct agtgcatgcc ttcttaaaca tcacgagact 1020ctaagaaaag
gaaactgaaa acgggaaagt ccctctctct aacctggcac tgcgtcgctg
1080gcttggagac aggtgacggt ccctgcgggc cttgtcctga ttggctgggc
acgcgtttaa 1140tataagtgga ggcgtcgcgc tggcgggcat tcctgaagct
gacagcattc gggccgagat 1200ctagataact tcgtataatg tatgctatac
gaagttatgg atccatcgat tctgcgatcg 1260ctccggtgcc cgtcagtggg
cagagcgcac atcgcccaca gtccccgaga agttgggggg 1320aggggtcggc
aattgaaccg gtgcctagag aaggtggcgc ggggtaaact gggaaagtga
1380tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata
taagtgcagt 1440agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc
agaacacagc tgaagcttcc 1500accatgccca cgctactgcg ggtttatata
gacggtcccc acgggatggg gaaaaccacc 1560accacgcaac tgctggtggc
cctgggttcg cgcgacgata tcgtctacgt acccgagccg 1620atgacttact
ggcgggtgct gggggcttcc gagacaatcg cgaacatcta caccacacaa
1680caccgcctcg accagggtga gatatcggcc ggggacgcgg cggtggtaat
gacaagcgcc 1740cagataacaa tgggcatgcc ttatgccgtg accgacgccg
ttctggctcc tcatatcggg 1800ggggaggctg ggagctcaca tgccccgccc
ccggccctca ccctcatctt cgaccgccat 1860cccatcgccg ccctcctgtg
ctacccggcc gcgcggtacc ttatgggcag catgaccccc 1920caggccgtgc
tggcgttcgt ggccctcatc ccgccgacct tgcccggcac caacatcgtg
1980cttggggccc ttccggagga cagacacatc gaccgcctgg ccaaacgcca
gcgccccggc 2040gagcggctgg acctggctat gctggctgcg attcgccgcg
tttacgggct acttgccaat 2100acggtgcggt atctgcagtg cggcgggtcg
tggcgggagg actggggaca gctttcgggg 2160acggccgtgc cgccccaggg
tgccgagccc cagagcaacg cgggcccacg accccatatc 2220ggggacacgt
tatttaccct gtttcgggcc cccgagttgc tggcccccaa cggcgacctg
2280tataacgtgt ttgcctgggc cttggacgtc ttggccaaac gcctccgttc
catgcacgtc 2340tttatcctgg attacgacca atcgcccgcc ggctgccggg
acgccctgct gcaacttacc 2400tccgggatgg tccagaccca cgtcaccacc
cccggctcca taccgacgat atgcgacctg 2460gcgcgcacgt ttgcccggga
gatgggatcg gccattgaac aagatggatt gcacgcaggt 2520tctccggccg
cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc
2580tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct
ttttgtcaag 2640accgacctgt ccggtgccct gaatgaactg caggacgagg
cagcgcggct atcgtggctg 2700gccacgacgg gcgttccttg cgcagctgtg
ctcgacgttg tcactgaagc gggaagggac 2760tggctgctat tgggcgaagt
gccggggcag gatctcctgt catctcacct tgctcctgcc 2820gagaaagtat
ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc
2880tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg
gatggaagcc 2940ggtcttgtcg atcaggatga tctggacgaa gagcatcagg
ggctcgcgcc agccgaactg 3000ttcgccaggc tcaaggcgcg catgcccgac
ggcgaggatc tcgtcgtgac ccatggcgat 3060gcctgcttgc cgaatatcat
ggtggaaaat ggccgctttt ctggattcat cgactgtggc 3120cggctgggtg
tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa
3180gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc
cgctcccgat 3240tcgcagcgca tcgccttcta tcgccttctt gacgagttct
tctgagggtc tctagcataa 3300cttcgtataa tgtatgctat acgaagttat
aataaaagat ccttattttc attggatctg 3360tgtgttggtt ttttgtgtgg
gatccgtcga taccgtcgac tgtctcgctc cgtggcctta 3420gctgtgctcg
cgctactctc tctttctggc ctggaggcta tccagcgtga gtctctccta
3480ccctcccgct ctggtccttc ctctcccgct ctgcaccctc tgtggccctc
gctgtgctct 3540ctcgctccgt gacttccctt ctccaagttc tccttggtgg
cccgccgtgg ggctagtcca 3600gggctggatc tcggggaagc ggcggggtgg
cctgggagtg gggaaggggg tgcgcacccg 3660ggacgcgcgc tacttgcccc
tttcggcggg gagcagggga gacctttggc ctacggcgac 3720gggagggtcg
ggacaaagtt tagggcgtcg ataagcgtca gagcgccgag gttgggggag
3780ggtttctctt ccgctctttc gcggggcctc tggctccccc agcgcagctg
gagtggggga 3840cgggtaggct cgtcccaaag gcgcggcgct gaggtttgtg
aacgcgtgga ggggcgcttg 3900gggtctgggg gaggcgtcgc ccgggtaagc
ctgtctgctg cggctctgct tcccttagac 3960tggagagctg tggacttcgt
ctaggcgccc gctaagttcg catgtcctag cacctctggg 4020tctatgtggg
gccacaccgt ggggaggaaa cagcacgcga cgtttgtaga atgcttggct
4080gtgatacaaa gcggtttcga ataattaact tatttgttcc catcacatgt
cacttttaaa 4140aaattataag aactacccgt tattgacatc tttctgtgtg
ccaaggactt tatgtgcttt 4200gcgtcattta attttgaaaa cagttatctt
ccgccataga taactactat ggttatcttc 4260tgcctctcac agatgaagaa
actaaggcac cgagatttta agaaacttaa ttacacaggg 4320gataaatggc
agcaatcgag attgaagtca agcctaacca gggcttttgc gggagcgcat
4380gccttttggc tgtaattcgt gcgcggccgc aggaacccct agtgatggag
ttggccactc 4440cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc
aaaggtcgcc cgacgcccgg 4500gctttgcccg ggcggcctca gtgagcgagc
gagcgcgcag ctgcctgcag gggcgcctga 4560tgcggtattt tctccttacg
catctgtgcg gtatttcaca ccgcatacgt caaagcaacc 4620atagtacgcg
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt
4680gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc
cttcctttct 4740cgccacgttc gccggctttc cccgtcaagc tctaaatcgg
gggctccctt tagggttccg 4800atttagtgct ttacggcacc tcgaccccaa
aaaacttgat ttgggtgatg gttcacgtag 4860tgggccatcg ccctgataga
cggtttttcg ccctttgacg ttggagtcca cgttctttaa 4920tagtggactc
ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga
4980tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga
tttaacaaaa 5040atttaacgcg aattttaaca aaatattaac gtttacaatt
ttatggtgca ctctcagtac 5100aatctgctct gatgccgcat agttaagcca
gccccgacac ccgccaacac ccgctgacgc 5160gccctgacgg gcttgtctgc
tcccggcatc cgcttacaga caagctgtga ccgtctccgg 5220gagctgcatg
tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct
5280cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt
agacgtcagg 5340tggcactttt cggggaaatg tgcgcggaac ccctatttgt
ttatttttct aaatacattc 5400aaatatgtat ccgctcatga gacaataacc
ctgataaatg cttcaataat attgaaaaag 5460gaagagtatg agtattcaac
atttccgtgt cgcccttatt cccttttttg cggcattttg 5520ccttcctgtt
tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt
5580gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc
ttgagagttt 5640tcgccccgaa gaacgttttc caatgatgag cacttttaaa
gttctgctat gtggcgcggt 5700attatcccgt attgacgccg ggcaagagca
actcggtcgc cgcatacact attctcagaa 5760tgacttggtt gagtactcac
cagtcacaga aaagcatctt acggatggca tgacagtaag 5820agaattatgc
agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac
5880aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg
atcatgtaac 5940tcgccttgat cgttgggaac cggagctgaa tgaagccata
ccaaacgacg agcgtgacac 6000cacgatgcct gtagcaatgg caacaacgtt
gcgcaaacta ttaactggcg aactacttac 6060tctagcttcc cggcaacaat
taatagactg gatggaggcg gataaagttg caggaccact 6120tctgcgctcg
gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg
6180tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc
gtatcgtagt 6240tatctacacg acggggagtc aggcaactat ggatgaacga
aatagacaga tcgctgagat 6300aggtgcctca ctgattaagc attggtaact
gtcagaccaa gtttactcat atatacttta 6360gattgattta aaacttcatt
tttaatttaa aaggatctag gtgaagatcc tttttgataa 6420tctcatgacc
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga
6480aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct
gcttgcaaac 6540aaaaaaacca ccgctaccag cggtggtttg tttgccggat
caagagctac caactctttt 6600tccgaaggta actggcttca gcagagcgca
gataccaaat actgtccttc tagtgtagcc 6660gtagttaggc caccacttca
agaactctgt agcaccgcct acatacctcg ctctgctaat 6720cctgttacca
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag
6780acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt
gcacacagcc 6840cagcttggag cgaacgacct acaccgaact gagataccta
cagcgtgagc tatgagaaag 6900cgccacgctt cccgaaggga gaaaggcgga
caggtatccg gtaagcggca gggtcggaac 6960aggagagcgc acgagggagc
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg 7020gtttcgccac
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct
7080atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct
ggccttttgc 7140tcacatgtcc tgcaggcag 7159227199DNAArtificial
SequenceVector sequence for pA2-B2MEHyTKpA 22cctgcaggca gctgcgcgct
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60gggcgacctt tggtcgcccg
gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120actccatcac
taggggttcc tgcggccgcg aaactaagag aatgatgtac ctagagggcg
180ctggaagctc taaagcccta gcagttactg cttttactat tagtggtcgt
ttttttctcc 240cccccgcccc ccgacaaatc aacagaacaa agaaaattac
ctaaacagca aggacatagg 300gaggaacttc ttggcacaga actttccaaa
cactttttcc tgaagggata caagaagcaa 360gaaaggtact ctttcactag
gaccttctct gagctgtcct caggatgctt ttgggactat 420ttttcttacc
cagagaatgg agaaaccctg cagggaattc ccaagctgta gttataaaca
480gaagttctcc ttctgctagg tagcattcaa agatcttaat cttctgggtt
tccgttttct 540cgaatgaaaa atgcaggtcc gagcagttaa ctggctgggg
caccattagc aagtcactta 600gcatctctgg ggccagtctg caaagcgagg
gggcagcctt aatgtgcctc cagcctgaag 660tcctagaatg agcgcccggt
gtcccaagct ggggcgcgca ccccagatcg gagggcgccg 720atgtacagac
agcaaactca cccagtctag tgcatgcctt cttaaacatc acgagactct
780aagaaaagga aactgaaaac gggaaagtcc ctctctctaa cctggcactg
cgtcgctggc 840ttggagacag gtgacggtcc ctgcgggcct tgtcctgatt
ggctgggcac gcgtttaata 900taagtggagg cgtcgcgctg gcgggcattc
ctgaagctga cagcattcgg gccgagatct 960agataacttc gtataatgta
tgctatacga agttatggat ccatcgattc tgcgatcgct 1020ccggtgcccg
tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag
1080gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg
gaaagtgatg 1140tcgtgtactg gctccgcctt tttcccgagg gtgggggaga
accgtatata agtgcagtag 1200tcgccgtgaa cgttcttttt cgcaacgggt
ttgccgccag aacacagctg aagcttccac 1260catgaaaaag cctgaactca
ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga 1320cagcgtctcc
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga
1380tgtaggaggg cgtggatatg tcctgcgggt aaatagctgc gccgatggtt
tctacaaaga 1440tcgttatgtt tatcggcact ttgcatcggc cgcgctcccg
attccggaag tgcttgacat 1500tggggaattc agcgagagcc tgacctattg
catctcccgc cgtgcacagg gtgtcacgtt 1560gcaagacctg cctgaaaccg
aactgcccgc tgttctgcag ccggtcgcgg aggccatgga 1620tgcgatcgct
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg
1680aatcggtcaa tacactacat ggcgtgattt catatgcgcg attgctgatc
cccatgtgta 1740tcactggcaa actgtgatgg acgacaccgt cagtgcgtcc
gtcgcgcagg ctctcgatga 1800gctgatgctt tgggccgagg actgccccga
agtccggcac ctcgtgcacg cggatttcgg 1860ctccaacaat gtcctgacgg
acaatggccg cataacagcg gtcattgact ggagcgaggc 1920gatgttcggg
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc
1980ttgtatggag cagcagacgc gctacttcga gcggaggcat ccggagcttg
caggatcgcc 2040gcggctccgg gcgtatatgc tccgcattgg tcttgaccaa
ctctatcaga gcttggttga 2100cggcaatttc gatgatgcag cttgggcgca
gggtcgatgc gacgcaatcg tccgatccgg 2160agccgggact gtcgggcgta
cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg 2220ctgtgtagaa
gtcgcgtctg cgttcgacca ggctgcgcgt tctcgcggcc atagcaaccg
2280acgtacggcg ttgcgccctc gccggcagca agaagccacg gaagtccgcc
cggagcagaa 2340aatgcccacg ctactgcggg tttatataga cggtccccac
gggatgggga aaaccaccac 2400cacgcaactg ctggtggccc tgggttcgcg
cgacgatatc gtctacgtac ccgagccgat 2460gacttactgg cgggtgctgg
gggcttccga gacaatcgcg aacatctaca ccacacaaca 2520ccgcctcgac
cagggtgaga tatcggccgg ggacgcggcg gtggtaatga caagcgccca
2580gataacaatg ggcatgcctt atgccgtgac cgacgccgtt ctggctcctc
atatcggggg 2640ggaggctggg agctcacatg ccccgccccc ggccctcacc
ctcatcttcg accgccatcc 2700catcgccgcc ctcctgtgct acccggccgc
gcggtacctt atgggcagca tgacccccca 2760ggccgtgctg gcgttcgtgg
ccctcatccc gccgaccttg cccggcacca acatcgtgct 2820tggggccctt
ccggaggaca gacacatcga ccgcctggcc aaacgccagc gccccggcga
2880gcggctggac ctggctatgc tggctgcgat tcgccgcgtt tacgggctac
ttgccaatac 2940ggtgcggtat ctgcagtgcg gcgggtcgtg gcgggaggac
tggggacagc tttcggggac 3000ggccgtgccg ccccagggtg ccgagcccca
gagcaacgcg ggcccacgac cccatatcgg 3060ggacacgtta tttaccctgt
ttcgggcccc cgagttgctg gcccccaacg gcgacctgta 3120taacgtgttt
gcctgggcct tggacgtctt ggccaaacgc ctccgttcca tgcacgtctt
3180tatcctggat tacgaccaat cgcccgccgg ctgccgggac gccctgctgc
aacttacctc 3240cgggatggtc cagacccacg tcaccacccc cggctccata
ccgacgatat gcgacctggc 3300gcgcacgttt gcccgggaga tgggggaggc
taactgaggt ctctagcata acttcgtata
3360atgtatgcta tacgaagtta taataaaaga tccttatttt cattggatct
gtgtgttggt 3420tttttgtgtg ggatccgtcg ataccgtcga ctgtctcgct
ccgtggcctt agctgtgctc 3480gcgctactct ctctttctgg cctggaggct
atccagcgtg agtctctcct accctcccgc 3540tctggtcctt cctctcccgc
tctgcaccct ctgtggccct cgctgtgctc tctcgctccg 3600tgacttccct
tctccaagtt ctccttggtg gcccgccgtg gggctagtcc agggctggat
3660ctcggggaag cggcggggtg gcctgggagt ggggaagggg gtgcgcaccc
gggacgcgcg 3720ctacttgccc ctttcggcgg ggagcagggg agacctttgg
cctacggcga cgggagggtc 3780gggacaaagt ttagggcgtc gataagcgtc
agagcgccga ggttggggga gggtttctct 3840tccgctcttt cgcggggcct
ctggctcccc cagcgcagct ggagtggggg acgggtaggc 3900tcgtcccaaa
ggcgcggcgc tgaggtttgt gaacgcgtgg aggggcgctt ggggtctggg
3960ggaggcgtcg cccgggtaag cctgtctgct gcggctctgc ttcccttaga
ctggagagct 4020gtggacttcg tctaggcgcc cgctaagttc gcatgtccta
gcacctctgg gtctatgtgg 4080ggccacaccg tggggaggaa acagcacgcg
acgtttgtag aatgcttggc tgtgatacaa 4140agcggtttcg aataattaac
ttatttgttc ccatcacatg tcacttttaa aaaattataa 4200gaactacccg
ttattgacat ctttctgtgt gccaaggact ttatgtgctt tgcgtcattt
4260aattttgaaa acagttatct tccgccatag ataactacta tggttatctt
ctgcctctca 4320cagatgaaga aactaaggca ccgagatttt aagaaactta
attacacagg ggataaatgg 4380cagcaatcga gattgaagtc aagcctaacc
agggcttttg cgggagcgca tgccttttgg 4440ctgtaattcg tgcgcggccg
caggaacccc tagtgatgga gttggccact ccctctctgc 4500gcgctcgctc
gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc
4560gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg
atgcggtatt 4620ttctccttac gcatctgtgc ggtatttcac accgcatacg
tcaaagcaac catagtacgc 4680gccctgtagc ggcgcattaa gcgcggcggg
tgtggtggtt acgcgcagcg tgaccgctac 4740acttgccagc gccctagcgc
ccgctccttt cgctttcttc ccttcctttc tcgccacgtt 4800cgccggcttt
ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc
4860tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta
gtgggccatc 4920gccctgatag acggtttttc gccctttgac gttggagtcc
acgttcttta atagtggact 4980cttgttccaa actggaacaa cactcaaccc
tatctcgggc tattcttttg atttataagg 5040gattttgccg atttcggcct
attggttaaa aaatgagctg atttaacaaa aatttaacgc 5100gaattttaac
aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc
5160tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg
cgccctgacg 5220ggcttgtctg ctcccggcat ccgcttacag acaagctgtg
accgtctccg ggagctgcat 5280gtgtcagagg ttttcaccgt catcaccgaa
acgcgcgaga cgaaagggcc tcgtgatacg 5340cctattttta taggttaatg
tcatgataat aatggtttct tagacgtcag gtggcacttt 5400tcggggaaat
gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta
5460tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa
ggaagagtat 5520gagtattcaa catttccgtg tcgcccttat tccctttttt
gcggcatttt gccttcctgt 5580ttttgctcac ccagaaacgc tggtgaaagt
aaaagatgct gaagatcagt tgggtgcacg 5640agtgggttac atcgaactgg
atctcaacag cggtaagatc cttgagagtt ttcgccccga 5700agaacgtttt
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg
5760tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga
atgacttggt 5820tgagtactca ccagtcacag aaaagcatct tacggatggc
atgacagtaa gagaattatg 5880cagtgctgcc ataaccatga gtgataacac
tgcggccaac ttacttctga caacgatcgg 5940aggaccgaag gagctaaccg
cttttttgca caacatgggg gatcatgtaa ctcgccttga 6000tcgttgggaa
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc
6060tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta
ctctagcttc 6120ccggcaacaa ttaatagact ggatggaggc ggataaagtt
gcaggaccac ttctgcgctc 6180ggcccttccg gctggctggt ttattgctga
taaatctgga gccggtgagc gtgggtctcg 6240cggtatcatt gcagcactgg
ggccagatgg taagccctcc cgtatcgtag ttatctacac 6300gacggggagt
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc
6360actgattaag cattggtaac tgtcagacca agtttactca tatatacttt
agattgattt 6420aaaacttcat ttttaattta aaaggatcta ggtgaagatc
ctttttgata atctcatgac 6480caaaatccct taacgtgagt tttcgttcca
ctgagcgtca gaccccgtag aaaagatcaa 6540aggatcttct tgagatcctt
tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc 6600accgctacca
gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt
6660aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc
cgtagttagg 6720ccaccacttc aagaactctg tagcaccgcc tacatacctc
gctctgctaa tcctgttacc 6780agtggctgct gccagtggcg ataagtcgtg
tcttaccggg ttggactcaa gacgatagtt 6840accggataag gcgcagcggt
cgggctgaac ggggggttcg tgcacacagc ccagcttgga 6900gcgaacgacc
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct
6960tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa
caggagagcg 7020cacgagggag cttccagggg gaaacgcctg gtatctttat
agtcctgtcg ggtttcgcca 7080cctctgactt gagcgtcgat ttttgtgatg
ctcgtcaggg gggcggagcc tatggaaaaa 7140cgccagcaac gcggcctttt
tacggttcct ggccttttgc tggccttttg ctcacatgt 71992329PRTArtificial
SequenceHLA-G peptide 23Met Ala Pro Arg Thr Leu Phe Leu Gly Gly Gly
Gly Ser Gly Gly Gly 1 5 10 15 Gly Ser Gly Gly Gly Gly Ser Ile Gln
Arg Thr Pro Lys 20 25
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