U.S. patent application number 13/791312 was filed with the patent office on 2014-05-08 for antibody derivatives. The applicant listed for this patent is William BRADY, Kenneth GRABSTEIN, Gordon KING, Natalie Winblade NAIRN, Kurt David SHANEBECK, Paul Heffner SLAGLE, Kenneth Christopher THORNTON, Michael Peter VANBRUNT, Andrea WANG, Hengyu XU. Invention is credited to William BRADY, Kenneth GRABSTEIN, Gordon KING, Natalie Winblade NAIRN, Kurt David SHANEBECK, Paul Heffner SLAGLE, Kenneth Christopher THORNTON, Michael Peter VANBRUNT, Andrea WANG, Hengyu XU.
Application Number | 20140127209 13/791312 |
Document ID | / |
Family ID | 44583080 |
Filed Date | 2014-05-08 |
United States Patent Application | 20140127209 |
Kind Code | A1 |
GRABSTEIN; Kenneth ; et al. | May 8, 2014 |
The invention relates inter alia to a bivalent, bispecific construct comprising an anti-IL-6 antibody, or derivative thereof, and an anti-IL-23 antibody, or derivative thereof and its use in therapy. The invention also relates to useful anti-IL-6 antibodies and anti-IL-23 antibodies.
Inventors: | GRABSTEIN; Kenneth; (Seattle, WA) ; BRADY; William; (Seattle, WA) ; KING; Gordon; (Seattle, WA) ; NAIRN; Natalie Winblade; (Seattle, WA) ; SHANEBECK; Kurt David; (Seattle, WA) ; SLAGLE; Paul Heffner; (Seattle, WA) ; THORNTON; Kenneth Christopher; (Seattle, WA) ; VANBRUNT; Michael Peter; (Seattle, WA) ; WANG; Andrea; (Seattle, WA) ; XU; Hengyu; (Seattle, WA) | ||||||||||
Applicant: |
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Family ID: | 44583080 | ||||||||||
Appl. No.: | 13/791312 | ||||||||||
Filed: | March 8, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
PCT/EP2011/065697 | Sep 9, 2011 | |||
13791312 | ||||
61381789 | Sep 10, 2010 | |||
Current U.S. Class: | 424/136.1 ; 530/387.3; 530/391.9 |
Current CPC Class: | C07K 2317/24 20130101; A61P 29/00 20180101; A61P 43/00 20180101; C07K 2317/40 20130101; A61K 2039/507 20130101; C07K 2317/565 20130101; C07K 2317/622 20130101; C07K 2317/33 20130101; C07K 2317/56 20130101; A61P 37/06 20180101; A61P 25/00 20180101; A61K 2039/505 20130101; A61P 37/02 20180101; A61P 3/10 20180101; A61P 17/06 20180101; C07K 16/244 20130101; C07K 16/468 20130101; A61P 1/00 20180101; C07K 16/248 20130101; C07K 2317/567 20130101; C07K 2317/92 20130101; A61P 19/02 20180101; C07K 2317/76 20130101; C07K 2317/31 20130101 |
Class at Publication: | 424/136.1 ; 530/387.3; 530/391.9 |
International Class: | C07K 16/46 20060101 C07K016/46 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 359 <210> SEQ ID NO 1 <211> LENGTH: 238
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: H.Sapiens 3X FLAG IL-6 Avi <400> SEQUENCE: 1 Met
Ser Ala Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala Asp 1 5 10
15 Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys
20 25 30 Asp Asp Asp Asp Lys Leu Val Pro Pro Gly Glu Asp Ser Lys
Asp Val 35 40 45 Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu
Arg Ile Asp Lys 50 55 60 Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser
Ala Leu Arg Lys Glu Thr 65 70 75 80 Cys Asn Lys Ser Asn Met Cys Glu
Ser Ser Lys Glu Ala Leu Ala Glu 85 90 95 Asn Asn Leu Asn Leu Pro
Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 100 105 110 Ser Gly Phe Asn
Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 115 120 125 Leu Glu
Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 130 135 140
Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 145
150 155 160 Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr
Thr Pro 165 170 175 Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu
Gln Ala Gln Asn 180 185 190 Gln Trp Leu Gln Asp Met Thr Thr His Leu
Ile Leu Arg Ser Phe Lys 195 200 205 Glu Phe Leu Gln Ser Ser Leu Arg
Ala Leu Arg Gln Met Ala Ser Gly 210 215 220 Leu Asn Asp Ile Phe Glu
Ala Gln Lys Ile Glu Trp His Glu 225 230 235 <210> SEQ ID NO 2
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: H.Sapiens 3X FLAG IL-6 Myc
<400> SEQUENCE: 2 Met Ser Ala Leu Leu Ile Leu Ala Leu Val Gly
Ala Ala Val Ala Asp 1 5 10 15 Tyr Lys Asp His Asp Gly Asp Tyr Lys
Asp His Asp Ile Asp Tyr Lys 20 25 30 Asp Asp Asp Asp Lys Leu Val
Pro Pro Gly Glu Asp Ser Lys Asp Val 35 40 45 Ala Ala Pro His Arg
Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 50 55 60 Gln Ile Arg
Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr 65 70 75 80 Cys
Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu 85 90
95 Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln
100 105 110 Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr
Gly Leu 115 120 125 Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn
Arg Phe Glu Ser 130 135 140 Ser Glu Glu Gln Ala Arg Ala Val Gln Met
Ser Thr Lys Val Leu Ile 145 150 155 160 Gln Phe Leu Gln Lys Lys Ala
Lys Asn Leu Asp Ala Ile Thr Thr Pro 165 170 175 Asp Pro Thr Thr Asn
Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 180 185 190 Gln Trp Leu
Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys 195 200 205 Glu
Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met Gly Asp Leu 210 215
220 Ile Ser Val Pro Val Asp Ser Arg Gly Ser Glu Gln Lys Leu Ile Ser
225 230 235 240 Glu Glu Asp Leu <210> SEQ ID NO 3 <211>
LENGTH: 222 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: M.Mulatta IL-6 1X FLAG <400> SEQUENCE: 3
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 1 5
10 15 Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Leu
Pro 20 25 30 Gly Glu Asp Ser Lys Asn Val Ala Ala Pro His Ser Gln
Pro Leu Thr 35 40 45 Ser Ser Glu Arg Ile Asp Lys His Ile Arg Tyr
Ile Leu Asp Gly Ile 50 55 60 Ser Ala Leu Arg Lys Glu Thr Cys Asn
Arg Ser Asn Met Cys Glu Ser 65 70 75 80 Ser Lys Glu Ala Leu Ala Glu
Asn Asn Leu Asn Leu Pro Lys Met Ala 85 90 95 Glu Lys Asp Gly Cys
Phe Gln Ser Gly Phe Asn Glu Asp Thr Cys Leu 100 105 110 Val Lys Ile
Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 115 120 125 Leu
Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 130 135
140 Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn
145 150 155 160 Leu Asp Ala Ile Thr Thr Pro Glu Pro Thr Thr Asn Ala
Ser Leu Leu 165 170 175 Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln
Asp Met Thr Thr His 180 185 190 Leu Ile Leu Arg Ser Phe Lys Glu Phe
Leu Gln Ser Asn Leu Arg Ala 195 200 205 Leu Arg Gln Met Ala Ser Asp
Tyr Lys Asp Asp Asp Asp Lys 210 215 220 <210> SEQ ID NO 4
<211> LENGTH: 514 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: H.Sapiens IL23-p40:p19-6xHIS
<400> SEQUENCE: 4 Met Gly His Gln Gln Leu Val Ile Ser Trp Phe
Ser Leu Val Phe Leu 1 5 10 15 Ala Ser Pro Leu Val Ala Ile Trp Glu
Leu Lys Lys Asp Val Tyr Val 20 25 30 Val Glu Leu Asp Trp Tyr Pro
Asp Ala Pro Gly Glu Met Val Val Leu 35 40 45 Thr Cys Asp Thr Pro
Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 50 55 60 Ser Ser Glu
Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 65 70 75 80 Glu
Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 85 90
95 Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp
100 105 110 Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys
Thr Phe 115 120 125 Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe
Thr Cys Trp Trp 130 135 140 Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe
Ser Val Lys Ser Ser Arg 145 150 155 160 Gly Ser Ser Asp Pro Gln Gly
Val Thr Cys Gly Ala Ala Thr Leu Ser 165 170 175 Ala Glu Arg Val Arg
Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 180 185 190 Cys Gln Glu
Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 195 200 205 Glu
Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 210 215
220 Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn
225 230 235 240 Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu
Val Ser Trp 245 250 255 Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser
Tyr Phe Ser Leu Thr 260 265 270 Phe Cys Val Gln Val Gln Gly Lys Ser
Lys Arg Glu Lys Lys Asp Arg 275 280 285 Val Phe Thr Asp Lys Thr Ser
Ala Thr Val Ile Cys Arg Lys Asn Ala 290 295 300 Ser Ile Ser Val Arg
Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 305 310 315 320 Glu Trp
Ala Ser Val Pro Cys Ser Val Pro Gly Val Gly Val Pro Gly 325 330 335
Val Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys 340
345 350 Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His
Pro 355 360 365 Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu
Glu Thr Thr 370 375 380 Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly
Cys Asp Pro Gln Gly 385 390 395 400 Leu Arg Asp Asn Ser Gln Phe Cys
Leu Gln Arg Ile His Gln Gly Leu 405 410 415 Ile Phe Tyr Glu Lys Leu
Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro 420 425 430 Ser Leu Leu Pro
Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu 435 440 445 Gly Leu
Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln 450 455 460
Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu 465
470 475 480 Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val
Ala Ala 485 490 495 Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro
His His His His 500 505 510 His His <210> SEQ ID NO 5
<211> LENGTH: 511 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: M.Mulatta IL23-p40:p19-6xHIS
<400> SEQUENCE: 5 Met Ser Ala Leu Leu Ile Leu Ala Leu Val Gly
Ala Ala Val Ala Lys 1 5 10 15 Leu Ile Trp Glu Leu Lys Lys Asp Val
Tyr Val Val Glu Leu Asp Trp 20 25 30 Tyr Pro Asp Ala Pro Gly Glu
Met Val Val Leu Thr Cys Asp Thr Pro 35 40 45 Glu Glu Asp Gly Ile
Thr Trp Thr Leu Asp Gln Ser Gly Glu Val Leu 50 55 60 Gly Ser Gly
Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 65 70 75 80 Gly
Gln Tyr Thr Cys His Lys Gly Gly Glu Ala Leu Ser His Ser Leu 85 90
95 Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Val Leu
100 105 110 Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys
Glu Ala 115 120 125 Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu
Thr Thr Ile Ser 130 135 140 Thr Asp Leu Thr Phe Ser Val Lys Ser Ser
Arg Gly Ser Ser Asn Pro 145 150 155 160 Gln Gly Val Thr Cys Gly Ala
Val Thr Leu Ser Ala Glu Arg Val Arg 165 170 175 Gly Asp Asn Lys Glu
Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 180 185 190 Ala Cys Pro
Ala Ala Glu Glu Arg Leu Pro Ile Glu Val Met Val Asp 195 200 205 Ala
Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 210 215
220 Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro
225 230 235 240 Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr
Pro Asp Thr 245 250 255 Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr
Phe Cys Ile Gln Val 260 265 270 Gln Gly Lys Ser Lys Arg Glu Lys Lys
Asp Arg Ile Phe Thr Asp Lys 275 280 285 Thr Ser Ala Thr Val Ile Cys
Arg Lys Asn Ala Ser Phe Ser Val Gln 290 295 300 Ala Gln Asp Arg Tyr
Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 305 310 315 320 Pro Cys
Ser Arg Ser Val Pro Gly Val Gly Val Pro Gly Val Gly Arg 325 330 335
Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Ala Gln Cys Gln Gln Leu 340
345 350 Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val
Gly 355 360 365 His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr
Asn Asp Val 370 375 380 Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro
Gln Gly Leu Arg Asp 385 390 395 400 Asn Ser Gln Phe Cys Leu Gln Arg
Ile Arg Gln Gly Leu Ile Phe Tyr 405 410 415 Glu Lys Leu Leu Gly Ser
Asp Ile Phe Thr Gly Glu Pro Ser Leu Leu 420 425 430 Pro Asp Ser Pro
Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu Ser 435 440 445 Gln Leu
Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile Pro 450 455 460
Ser Pro Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe Lys 465
470 475 480 Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg
Val Phe 485 490 495 Ala His Gly Ala Ala Thr Leu Ser Pro His His His
His His His 500 505 510 <210> SEQ ID NO 6 <211> LENGTH:
119 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 6 Gln Ser Val Glu Glu Ser Gly Gly
Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr
Val Ser Gly Ile Asp Leu Ser Ser Tyr Asp 20 25 30 Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile
Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp Ala Lys Gly 50 55 60
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 65
70 75 80 Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Lys Gly 85 90 95 Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu
Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115
<210> SEQ ID NO 7 <211> LENGTH: 414 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 7 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt
ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc acgcctggga
cacccctgac actcacctgc 120 acagtctctg gaatcgacct cagtagctac
gacatgagct gggtccgcca ggctccaggg 180 aaggggctgg agtggatcgg
atacatttat actgatagta gcacatggta cgcgaactgg 240 gcgaaaggcc
gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc 300
agtctgacaa ccgaggacac ggccacctat ttctgtgcca aaggtagtac cgattatgct
360 ttcgacactc ggttggatct ctggggccca ggcaccctgg tcaccgtctc gagt 414
<210> SEQ ID NO 8 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 8 Asn Ile Val Met Thr Gln Thr Pro Ser Pro Val Ser Gly Ala
Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser
Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Arg Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Thr Ser
Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ala Gly Thr Gln
Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 65 70 75 80 Ala Asp Ala Ala
Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val Asp
Asn Val Phe Gly Gly Gly Thr Lys Val Val Val Val Arg 100 105 110
<210> SEQ ID NO 9 <211> LENGTH: 333 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 9 aacatcgtga tgacccagac tccatccccc gtgtctggag ctgtgggagg
cacagtcacc 60 atcaattgcc aggccagtca gagcattagc aatgaattat
cctggtatca gcagaaacca 120 gggcagcctc ccaggctcct gatctacagg
gcatccactc tgacatctgg ggtctcatcg 180 cggttcaaag gcagtggagc
tgggacgcag ttcactctca ccatcagcgg cgtggagtgt 240 gccgatgctg
ccacttacta ctgtcaacag ggttataata gtaatgatgt tgataatgtt 300
ttcggcggag ggaccaaggt ggtggtcgtc cgt 333 <210> SEQ ID NO 10
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 10 Ser Tyr Asp Met Ser
1 5 <210> SEQ ID NO 11 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 11 Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp
Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 12 <211> LENGTH:
13 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 12 Gly Ser Thr Asp Tyr Ala Phe Asp
Thr Arg Leu Asp Leu 1 5 10 <210> SEQ ID NO 13 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 13 Gln Ala Ser Gln Ser Ile Ser Asn
Glu Leu Ser 1 5 10 <210> SEQ ID NO 14 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 14 Arg Ala Ser Thr Leu Thr Ser 1 5
<210> SEQ ID NO 15 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 15 Gln Gln Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10
<210> SEQ ID NO 16 <211> LENGTH: 121 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 16 Gln Ser Leu Gly Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser
Leu Ser Lys Asn Ala 20 25 30 Ile Ala Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Tyr Ala Gly Gly Ala
Thr Thr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Ser Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr
Thr Val Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Tyr 85 90 95 Ala
Gly Asp Ser Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp Leu Trp Gly 100 105
110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID
NO 17 <211> LENGTH: 363 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 17 cagtcgctgg
gggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc 60
tgcacagtct ctggattatc cctcagtaag aatgcaattg cctgggtccg ccaggctcca
120 gggaagggac tggaatggat cggaatcatt tatgctggtg gtgccacaac
ctacgcgagc 180 tgggcgaaag gccgattcac catctccaag tcctcgacca
cggtggatct gaagatcacc 240 agtccgacaa cagtggacac ggccacctat
ttctgtgcca gggaatatgc tggtgatagt 300 tattatactg gatacactca
gttggatctc tggggcccag gcaccctggt caccgtctcg 360 agt 363 <210>
SEQ ID NO 18 <211> LENGTH: 112 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
18 Ala Leu Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly
1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Leu Phe
Ser Ser 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val
Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr
Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr
Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr 85 90 95 Pro Asp Pro Ile
Tyr Gly Phe Gly Gly Gly Thr Lys Val Val Val Val 100 105 110
<210> SEQ ID NO 19 <211> LENGTH: 336 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 19 gcccttgtga tgacccagac tccagcctcc gtgtctgccg ctgtgggagg
cacagtgacc 60 atcaattgcc aggccagtga ggaccttttt agtagtttgg
cctggtttca gcagaaacca 120 gggcagcctc ccaaactcct gatctattct
gcatccactc tggcatctgg ggtcccatcg 180 cggttcagcg gcagtggatc
tgggacagaa ttcactctca ccatcagcga cctggaatgt 240 gccgatgctg
ccacttacta ctgtctaggc ctttactatt atcttactcc tgatcctatt 300
tatgggttcg gcggagggac caaggtggtg gtggtc 336 <210> SEQ ID NO
20 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 20 Lys Asn
Ala Ile Ala 1 5 <210> SEQ ID NO 21 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 21 Ile Ile Tyr Ala Gly Gly Ala Thr Thr Tyr
Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 22
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 22 Glu Tyr Ala Gly Asp
Ser Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp 1 5 10 15 <210> SEQ
ID NO 23 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 23 Gln Ala
Ser Glu Asp Leu Phe Ser Ser Leu Ala 1 5 10 <210> SEQ ID NO 24
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 24 Ser Ala Ser Thr Leu
Ala Ser 1 5 <210> SEQ ID NO 25 <211> LENGTH: 14
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 25 Leu Gly Leu Tyr Tyr Tyr Leu Thr Pro Asp
Pro Ile Tyr Gly 1 5 10 <210> SEQ ID NO 26 <211> LENGTH:
121 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 26 Gln Ser Val Glu Glu Ser Gly Gly
Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr
Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Met Thr Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ser
Tyr Val Tyr Ser Gly Asp Thr Trp Tyr Ala Ser Trp Val Lys 50 55 60
Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 65
70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Arg Val 85 90 95 Gly Asp Tyr Asp Asp Tyr Gly Ala His Asp Val Phe
Asp Ser Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115
120 <210> SEQ ID NO 27 <211> LENGTH: 419 <212>
TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 27 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt
ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc acgcctggga
cacccctgac actcacctgc 120 acagtctctg gattctccct cagtagctat
gcaatgacct gggtccgcca ggctccaggg 180 aaggggctgg aatggatcgg
aaccagttat gtttatagtg gtgacacatg gtacgcgagc 240 tgggtgaaag
gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc 300
agtccgacaa ccgaggacac ggccacgtat ttctgtgcca gagttgggga ttacgatgac
360 tatggtgccc atgatgtttt tgattcctgg ggcccaggca ccctggtcac
cgtctcgag 419 <210> SEQ ID NO 28 <211> LENGTH: 111
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 28 Tyr Asp Met Thr Gln Thr Pro Ala Ser Val
Glu Val Ala Val Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala
Ser Glu Ser Ile Ser Ser Trp Leu 20 25 30 Ser Trp Tyr Gln Gln Lys
Pro Gly Gln Arg Pro Lys Leu Leu Leu Tyr 35 40 45 Arg Ala Ser Thr
Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly Ser 50 55 60 Gly Tyr
Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Glu 65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Gly Gly Asn Val 85
90 95 Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Val Val Val Arg Thr
100 105 110 <210> SEQ ID NO 29 <211> LENGTH: 402
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 29 atggacacga gggcccccac ccagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 agatgtgcct atgatatgac
ccagactcca gcctctgtgg aggtagctgt gggaggcaca 120 gtcaccatca
agtgccaggc cagtgagagc attagcagtt ggttatcctg gtatcagcag 180
aaaccagggc agcgtcccaa gctcctgctc tacagggcat ccactctggc atctggggtc
240 tcatcgcggt tcagcggcag tggatatggg acagagttca ctctcaccat
cagcggcgtg 300 cagtgtgaag atgctgccac ttactactgt caacagggtt
acactggtgg taatgttgat 360 aatgctttcg gcggagggac caaggtggtg
gtcgtccgta cg 402 <210> SEQ ID NO 30 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 30 Ser Tyr Ala Met Thr 1 5 <210> SEQ ID
NO 31 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 31 Thr Ser
Tyr Val Tyr Ser Gly Asp Thr Trp Tyr Ala Ser Trp Val Lys 1 5 10 15
Gly <210> SEQ ID NO 32 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 32 Val Gly Asp Tyr Asp Asp Tyr Gly Ala His Asp Val Phe
Asp Ser 1 5 10 15 <210> SEQ ID NO 33 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 33 Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu
Ser 1 5 10 <210> SEQ ID NO 34 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 34 Arg Ala Ser Thr Leu Ala Ser 1 5
<210> SEQ ID NO 35 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 35 Gln Gln Gly Tyr Thr Gly Gly Asn Val Asp Asn Ala 1 5 10
<210> SEQ ID NO 36 <211> LENGTH: 115 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 36 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro
Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Ser
Leu Ser Ser Ser Gly 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Val Ser Ile Ala Asp Thr
Ile Ser Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Ser Thr Thr Val Asp Leu Glu Met 65 70 75 80 Thr Ser Leu
Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly 85 90 95 Phe
Ile Thr Tyr Ser Gly Val Leu Trp Gly Pro Gly Thr Leu Val Thr 100 105
110 Val Ser Ser 115 <210> SEQ ID NO 37 <211> LENGTH:
402 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 37 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg
tcgtctggta gcgcctggag gctccctgac actcacctgc 120 aaagcctctg
gattctccct cagtagttct ggagtgagtt gggtccgcca ggctccaggg 180
aagggactgg aatggatcgg atacgttagt attgctgata ctatatccta cgcgaactgg
240 gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct
agaaatgacc 300 agtctgacaa ccgaggacac ggccacctat ttctgtgtca
gaggtttcat tacttatagt 360 ggtgtcttgt ggggcccagg caccctggtc
accgtctcga gt 402 <210> SEQ ID NO 38 <211> LENGTH: 110
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 38 Gln Val Leu Thr Gln Thr Pro Ala Ser Val
Ser Ala Ala Val Gly Gly 1 5 10 15 Thr Val Thr Ile Ser Cys Gln Ser
Ser Gln Asn Val Tyr Ser Asn Ala 20 25 30 Phe Leu Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Lys Ala
Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser
Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 65 70 75 80
Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Glu Tyr Glu Gly Gly 85
90 95 Ile Gly Thr Phe Gly Gly Gly Thr Glu Val Val Val Val Arg 100
105 110 <210> SEQ ID NO 39 <211> LENGTH: 399
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 39 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 acatttgcgc aagtgctgac
ccagactcca gcctccgtgt ctgcagctgt gggaggcaca 120 gtcaccatca
gttgccagtc cagtcagaat gtttatagta acgccttctt atcctggtat 180
cagcagaaac cagggcagcc tcccaagctc ctgatctaca aggcatccaa actggcatct
240 ggggtcccat cgcgattcag cggcagtggg tctgggacac agttcactct
caccatcagc 300 ggcgtccagt gtgacgatgc tgccacttat tattgtgcag
gcgaatatga aggtggtatc 360 ggtactttcg gcggagggac cgaggtggtg
gtggtccgt 399 <210> SEQ ID NO 40 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 40 Ser Ser Gly Val Ser 1 5 <210> SEQ ID
NO 41 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 41 Tyr Val
Ser Ile Ala Asp Thr Ile Ser Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 42 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 42 Gly Phe Ile Thr Tyr Ser Gly Val Leu 1 5 <210>
SEQ ID NO 43 <211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
43 Gln Ser Ser Gln Asn Val Tyr Ser Asn Ala Phe Leu Ser 1 5 10
<210> SEQ ID NO 44 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 44 Lys Ala Ser Lys Leu Ala Ser 1 5 <210> SEQ ID NO
45 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 45 Ala Gly
Glu Tyr Glu Gly Gly Ile Gly Thr 1 5 10 <210> SEQ ID NO 46
<211> LENGTH: 118 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 46 Gln Ser Leu Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu
Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 20 25 30 Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40
45 Tyr Ile Tyr Thr Asp Thr Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
50 55 60 Arg Phe Ser Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys
Met Thr 65 70 75 80 Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Lys Gly Ser 85 90 95 Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115
<210> SEQ ID NO 47 <211> LENGTH: 411 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 47 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt
ccagtgtcag 60 tcgctggagg agtccggggg tcgcctggtc acgcctggga
cacccctgac actcacctgc 120 acagcctctg gattctccct cagtagctac
gacatgagct gggtccgcca ggctccaggg 180 aaggggctgg agtggatcgg
atacatttat actgatacta gtacatacta cgcgaactgg 240 gcgaaaggcc
gattctccat ctccaaaacc tcgaccacgg tggatctgaa aatgaccagt 300
ctgacagccg aggacacggc cacctatttc tgtgccaaag gtagtaccga ttatgctttc
360 gacactcggt tggatctgtg gggcccaggc accctggtca ccgtctcgag t 411
<210> SEQ ID NO 48 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 48 Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala
Met Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser
Ile Ser Asn Glu Leu 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Tyr 35 40 45 Arg Thr Ser Thr Leu Ala Ser
Gly Val Ser Ser Arg Phe Lys Gly Ser 50 55 60 Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys Ala 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp Val 85 90 95 Asp
Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Val Arg Thr 100 105 110
<210> SEQ ID NO 49 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 49 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgcct atgatatgac ccagactcca gcctctgtgg
aggtagctat gggaggcaca 120 gtcaccatca agtgccaggc cagtcagagc
attagcaatg aattatcctg gtatcagcag 180 aaaccagggc agcctcccaa
gctcctgatc tacaggacat ccactctggc atctggggtc 240 tcatcgcggt
tcaaaggcag tggatctggg acagagtaca ctctcaccat cagcggcgtg 300
gagtgtgccg atgctgccac ttactactgt caacagggtt ataatagtaa tgatgttgat
360 aatgttttcg gcggagggac cgaggtggtg gtcgtccgta cg 402 <210>
SEQ ID NO 50 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
50 Ser Tyr Asp Met Ser 1 5 <210> SEQ ID NO 51 <211>
LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 51 Tyr Ile Tyr Thr Asp Thr Ser Thr
Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 52
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 52 Gly Ser Thr Asp Tyr
Ala Phe Asp Thr Arg Leu Asp Leu 1 5 10 <210> SEQ ID NO 53
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 53 Gln Ala Ser Gln Ser
Ile Ser Asn Glu Leu Ser 1 5 10 <210> SEQ ID NO 54 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 54 Arg Thr Ser Thr Leu Ala Ser 1 5
<210> SEQ ID NO 55 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 55 Gln Gln Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10
<210> SEQ ID NO 56 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 56 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp
Leu Ser Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Tyr Thr Asp Ser Ser
Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Leu Thr
Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Lys Gly Ser 85 90 95 Thr
Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly Pro Gly Thr 100 105
110 Leu Val Thr Val Ser 115 <210> SEQ ID NO 57 <211>
LENGTH: 410 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 57 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg
tcgcctggtc acgcctggga cacccctgac actcacctgc 120 acagtctctg
gaatcgacct cagtagctac gacatgagct gggtccgcca ggctccaggg 180
aaggggctgg agtggatcgg atacatttat actgatagta gcacatacta cgcgaactgg
240 gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa
aatgaccagt 300 ctgacaaccg aggacacggc cacctatttc tgtgccaaag
gtagtaccga ttatgctttc 360 gacactcggt tggatctctg gggcccaggc
accctggtca ccgtctcgag 410 <210> SEQ ID NO 58 <211>
LENGTH: 112 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 58 Ala Tyr Asp Met Thr Gln Thr Pro
Ala Ser Val Glu Val Ala Met Gly 1 5 10 15 Gly Thr Val Thr Ile Lys
Cys Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg
Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys 65
70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser
Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Val
Val Val Arg Thr 100 105 110 <210> SEQ ID NO 59 <211>
LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 59 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 agatgtgcct atgatatgac
ccagactcca gcctctgtgg aggtagctat gggaggcaca 120 gtcaccatca
agtgccaggc cagtcagagc attagcaatg aattatcctg gtatcagcag 180
aaaccagggc agcctcccaa gctcctgatc tacaggacat ccactctggc atctggggtc
240 tcatcgcggt tcaaaggcag tggatctggg acagagtaca ctctcaccat
cagcggcgtg 300 gagtgtgccg atgctgccac ttactactgt caacagggtt
ataatagtaa tgatgttgat 360 aatgttttcg gcggagggac caaggtggtg
gtcgtccgta cg 402 <210> SEQ ID NO 60 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 60 Ser Tyr Asp Met Ser 1 5 <210> SEQ ID
NO 61 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 61 Tyr Ile
Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 62 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 62 Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu 1
5 10 <210> SEQ ID NO 63 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 63 Gln Ala Ser Gln Ser Ile Ser Asn Glu Leu Ser 1 5 10
<210> SEQ ID NO 64 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 64 Arg Thr Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
65 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 65 Gln Gln
Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10 <210> SEQ ID
NO 66 <211> LENGTH: 22 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
rCH1R1 <400> SEQUENCE: 66 gccagtggga agactgacgg ag 22
<210> SEQ ID NO 67 <211> LENGTH: 21 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rVHL-F <400> SEQUENCE: 67 atggagactg ggctgcgctg g 21
<210> SEQ ID NO 68 <211> LENGTH: 25 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJH-R1 <400> SEQUENCE: 68 ggagacggtg accagggtgc ctggg
25 <210> SEQ ID NO 69 <211> LENGTH: 22 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer rJH6R <400> SEQUENCE: 69 tgaagagacg
gtgacgaggg tc 22 <210> SEQ ID NO 70 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rCk1R1 <400> SEQUENCE: 70
gcagctggtg ggaagatgag gac 23 <210> SEQ ID NO 71 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer rVK5UTR <400>
SEQUENCE: 71 gccaggcagg acccagcatg gac 23 <210> SEQ ID NO 72
<211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rJK2-R
<400> SEQUENCE: 72 accaccacct yggtccctcc gcc 23 <210>
SEQ ID NO 73 <211> LENGTH: 24 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJK1-R <400> SEQUENCE: 73 gatttcyacc ttggtgccag ctcc
24 <210> SEQ ID NO 74 <211> LENGTH: 29 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer rJK24R <400> SEQUENCE: 74 gtttgatctc
caccttggtc cccgcaccg 29 <210> SEQ ID NO 75 <211>
LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer rJK2b9R <400>
SEQUENCE: 75 acttacatag gatctccagc tc 22 <210> SEQ ID NO 76
<211> LENGTH: 22 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rJK5R
<400> SEQUENCE: 76 gtttgatctc cagcttggtt cc 22 <210>
SEQ ID NO 77 <211> LENGTH: 36 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rVH1a-H3F <400> SEQUENCE: 77 gcgataagct tcaccatgga
gactgggctg cgctgg 36 <210> SEQ ID NO 78 <211> LENGTH:
32 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJH-XhoR ii <400> SEQUENCE:
78 gcgatctcga gacggtgacc agggtgcctg gg 32 <210> SEQ ID NO 79
<211> LENGTH: 34 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rJH6XhoIR
<400> SEQUENCE: 79 gcatagctcg aggagacggt gacgagggtc cctg 34
<210> SEQ ID NO 80 <211> LENGTH: 35 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rVKF-Nco <400> SEQUENCE: 80 gcgataccat ggacacgagg
gcccccactc agctg 35 <210> SEQ ID NO 81 <211> LENGTH: 38
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK2-BsiR2 <400> SEQUENCE:
81 gcgaacgtac ggacsaccac cacctyggtc cctccgcc 38 <210> SEQ ID
NO 82 <211> LENGTH: 38 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
rJK1-BsiR2 <400> SEQUENCE: 82 gcgaacgtac gtttgatttc
yaccttggtg ccagctcc 38 <210> SEQ ID NO 83 <211> LENGTH:
39 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK24BsiR <400> SEQUENCE: 83
gcatacgtac gtttgatctc caccttggtc cccgcaccg 39 <210> SEQ ID NO
84 <211> LENGTH: 32 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
rJK2b9BsiR <400> SEQUENCE: 84 gcatacgtac gtaggatctc
cagctcggtc cc 32 <210> SEQ ID NO 85 <211> LENGTH: 32
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK5BsiR <400> SEQUENCE: 85
gcatacgtac gtttgatctc cagcttggtt cc 32 <210> SEQ ID NO 86
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 86 Gln Ser Leu Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu
Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Trp 20 25 30 Met
Thr Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Ile Gly 35 40
45 Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg
50 55 60 Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met
Thr Ser 65 70 75 80 Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Arg Gly Leu Thr 85 90 95 Thr Asp Tyr Asp Leu Asp Leu Trp Gly Pro
Gly Thr Leu Val Thr Val 100 105 110 Ser Ser Ser 115 <210> SEQ
ID NO 87 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 87 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagcctctg gattctccct cagtagctac tggatgacct gggtccgcca
ggctccaggg 180 ggggggctgg agtggatcgg aaccattgct actagtagca
catactacgc gagctgggca 240 aaaggccgat tcaccatctc cagaacctcg
accacggtgg atctgaaaat gaccagtctg 300 acaaccgagg acacggccac
ctatttctgt gccagaggtc ttactactga ttatgacttg 360 gatctctggg
gaccagggac cctcgtcacc gtctcctcga gt 402 <210> SEQ ID NO 88
<211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 88 Leu Val Met Thr Gln
Thr Pro Ala Ser Val Ser Ala Ala Val Gly Gly 1 5 10 15 Thr Val Thr
Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu 20 25 30 Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 35 40
45 Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Lys Gly Ser
50 55 60 Gly Ser Gly Lys Gln Phe Thr Leu Thr Ile Ser Gly Val Gln
Arg Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp
Thr Thr Thr Val 85 90 95 Phe Gly Gly Gly Thr Lys Val Val Val Val
Arg Thr 100 105 <210> SEQ ID NO 89 <211> LENGTH: 393
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 89 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 agatgtgccc ttgtgatgac
ccagactcca gcctccgtgt ctgcagctgt gggaggcaca 120 gtcaccatca
attgccaggc cagtgaggac attgaaagct atttagcctg gtatcagcag 180
aaaccagggc agcgtcccaa gctcctgatc tattctgcat ccactctgac atctggggtc
240 ccatcgcggt tcaaaggcag tggatctggg aaacagttca ctctcaccat
cagcggcgtg 300 cagcgtgagg atgctgccac ctactactgt ctaggtgctg
atgatactac aactgttttc 360 ggcggaggga ccaaggtggt ggtcgtccgt acg 393
<210> SEQ ID NO 90 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 90 Ser Tyr Trp Met Thr 1 5 <210> SEQ ID NO 91
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 91 Thr Ile Ala Thr Ser
Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> SEQ
ID NO 92 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 92 Gly Leu
Thr Thr Asp Tyr Asp Leu Asp Leu 1 5 10 <210> SEQ ID NO 93
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 93 Gln Ala Ser Glu Asp
Ile Glu Ser Tyr Leu Ala 1 5 10 <210> SEQ ID NO 94 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 94 Ser Ala Ser Thr Leu Thr Ser 1 5
<210> SEQ ID NO 95 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 95 Leu Gly Ala Asp Asp Thr Thr Thr Val 1 5 <210>
SEQ ID NO 96 <211> LENGTH: 115 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
96 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser
1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asp
Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Ile Gly 35 40 45 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr
Ala Pro Trp Ala Glu Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser
Thr Thr Val Asp Leu Lys Met Ser 65 70 75 80 Ser Leu Thr Thr Glu Asp
Thr Ala Thr Tyr Phe Cys Ala Arg Glu Ala 85 90 95 Pro Gly Tyr Ser
Asp Gly Asp Ile Trp Gly Pro Gly Thr Leu Val Thr 100 105 110 Val Ser
Ser 115 <210> SEQ ID NO 97 <211> LENGTH: 402
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 97 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcgctggagg agtccggggg
tcgcctggta acgcctggag gatccctgac actcacctgc 120 acagtctctg
gaatcgacct cagtgactac gacatgagct gggtccgcca ggctccaggg 180
aaggggctgg aatggatcgg aatcgtgtat gatattggta ccatatacta cgcgccctgg
240 gcggaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa
aatgagcagt 300 ctgacaaccg aggacacggc cacctatttc tgtgccagag
aggctcctgg atatagtgat 360 ggggatatct ggggcccagg caccctggtc
accgtctcga gt 402 <210> SEQ ID NO 98 <211> LENGTH: 112
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 98 Ala Leu Val Met Thr Gln Thr Pro Ser Ser
Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln
Ala Ser Glu Thr Val Asp Asn Asn 20 25 30 Lys Arg Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly
Ala Ala Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly
Ser Gly Ser Gly Ala His Phe Thr Leu Thr Ile Ser Asn Val 65 70 75 80
Gln Arg Glu Asp Ala Ala Thr Tyr Val Cys Gly Gly Tyr Lys Asp Ser 85
90 95 Thr Asp Val Gly Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu Arg
Thr 100 105 110 <210> SEQ ID NO 99 <211> LENGTH: 402
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 99 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 acatttgccc tggtgatgac
ccagactcca tcctccgtgt ctgcagctgt gggaggcaca 120 gtcaccatca
attgccaggc cagtgagact gttgataata acaagcgctt atcgtggtat 180
cagcagaaac cagggcagcc tcccaagctc ctgatctatg gtgcagccac tctggcatct
240 ggggtcccat cgcggttcaa aggcagtgga tctggggcac acttcactct
caccatcagc 300 aacgtgcagc gtgaggatgc tgccacctac gtctgtggag
gttataaaga tagtactgat 360 gttggttttg gcggagggac cgagctggag
atcctacgta cg 402 <210> SEQ ID NO 100 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 100 Asp Tyr Asp Met Ser 1 5 <210> SEQ
ID NO 101 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 101 Ile Val
Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp Ala Glu Gly 1 5 10 15
<210> SEQ ID NO 102 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 102 Glu Ala Pro Gly Tyr Ser Asp Gly Asp Ile 1 5 10
<210> SEQ ID NO 103 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 103 Gln Ala Ser Glu Thr Val Asp Asn Asn Lys Arg Leu Ser 1
5 10 <210> SEQ ID NO 104 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 104 Gly Ala Ala Thr Leu Ala Ser 1 5 <210> SEQ ID NO
105 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 105 Gly Gly
Tyr Lys Asp Ser Thr Asp Val Gly 1 5 10 <210> SEQ ID NO 106
<211> LENGTH: 113 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 106 Gln Ser Val Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu
Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Ser 20 25 30 Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40
45 Val Ile Gly Leu Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly
50 55 60 Arg Phe Thr Ile Ser Gly Ala Ser Thr Thr Val Asp Leu Lys
Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Arg Ala Thr 85 90 95 Tyr Ser Asp Asp Asn Ile Trp Gly Pro Gly
Thr Leu Val Thr Val Ser 100 105 110 Ser <210> SEQ ID NO 107
<211> LENGTH: 396 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 107 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagtctctg gattctccct caatagttat tcaatgagct gggtccgcca
ggctccaggg 180 aaggggctgg aatggatcgg agtcattggt cttggtggta
gcgcatacta cgcgagctgg 240 gcgaaaggcc gattcaccat ctccggagcc
tcgaccacgg tggatctgaa aatcaccagt 300 ccgacaaccg aggacacggc
cacctatttc tgtgccagag ccacttatag tgatgataat 360 atctggggcc
caggcaccct ggtcaccgtc tcgagt 396 <210> SEQ ID NO 108
<211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 108 Asp Val Val Met Thr
Gln Thr Pro Ser Ser Thr Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val
Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Pro Leu Ile 35 40
45 Val Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly
50 55 60 Asn Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val
Gln Arg 65 70 75 80 Glu Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Gly Asp
Gly Asn Val Ser 85 90 95 Asn Phe Gly Gly Gly Thr Lys Val Val Val
Val Arg 100 105 <210> SEQ ID NO 109 <211> LENGTH: 390
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 109 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 agatgtgatg ttgtgatgac
ccagactcca tcctccacgt ctgcagctgt gggaggcaca 120 gtcaccatca
agtgccaggc cagtcagagc attagcagtt ggttatcctg gtatcagcag 180
aaaccagggc agcgtcccaa gcccctgatc gtcagggcat ccactctggc atctggggtc
240 ccatcgcggt tcaaaggcaa tagatctggg acagagtaca ctctcaccat
cagcggcgtg 300 cagcgtgagg atgctgccgc ctactactgt ctaggtggtg
atggtaatgt ttctaatttc 360 ggcggaggga ccaaggtggt ggtcgtccgt 390
<210> SEQ ID NO 110 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 110 Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Ser Met Ser 1
5 10 <210> SEQ ID NO 111 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 111 Val Ile Gly Leu Gly Gly Ser Ala Tyr Tyr Ala Ser Trp
Ala Lys 1 5 10 15 <210> SEQ ID NO 112 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 112 Ala Thr Tyr Ser Asp Asp Asn Ile 1 5
<210> SEQ ID NO 113 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 113 Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ser 1 5 10
<210> SEQ ID NO 114 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 114 Arg Ala Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
115 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 115 Leu Gly
Gly Asp Gly Asn Val Ser Asn 1 5 <210> SEQ ID NO 116
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 116 Gln Glu Gln Leu Lys
Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 1 5 10 15 Ser Leu Thr
Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 20 25 30 Asp
Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40
45 Gly Tyr Ile Tyr Arg Gly Ser Pro Tyr Tyr Ala Asp Trp Ala Lys Gly
50 55 60 Arg Phe Thr Ile Ser Ser Thr Ser Thr Thr Val Gly Leu Lys
Ile Thr 65 70 75 80 Ser Pro Thr Thr Val Asp Thr Ala Thr Tyr Phe Cys
Thr Arg Asn Leu 85 90 95 Tyr Ser Val Asn Val Leu Trp Gly Pro Gly
Thr Leu Val Thr Val Ser 100 105 110 <210> SEQ ID NO 117
<211> LENGTH: 395 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 117 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
gagcaactga aggagtccgg aggaggcctg gtaacgcctg gaggatccct gacactcacc
120 tgcacagtct ctggattctc cctcagtacc tacgacataa actgggtccg
ccaggctcca 180 gggaaggggc tggagtggat cggatatatt tatcgtggta
gcccatacta cgcggactgg 240 gcgaagggcc gattcaccat ctccagcacc
tcgaccacgg tgggtctgaa gatcaccagt 300 ccgacaaccg tggacacggc
cacctatttc tgtaccagaa acctttatag tgttaatgtc 360 ctctggggcc
caggcaccct ggtcaccgtc tcgag 395 <210> SEQ ID NO 118
<211> LENGTH: 109 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 118 Leu Val Met Thr Gln
Thr Pro Ser Ser Thr Ser Ala Ala Val Gly Asp 1 5 10 15 Thr Val Thr
Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu 20 25 30 Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 35 40
45 Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser
50 55 60 Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Val Gln
Arg Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ser
Asn Thr Ile Arg 85 90 95 Thr Phe Gly Ala Gly Thr Lys Val Glu Ile
Lys Arg Thr 100 105 <210> SEQ ID NO 119 <211> LENGTH:
396 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 119 atggacacga gggcccccac
tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60 agatgtgccc
tggtgatgac ccagactcca tcctccacat ctgccgctgt gggagacaca 120
gtcaccatca agtgccaggc cagtcagagc attagtagta gattagcctg gtatcagcag
180 aaaccagggc agcctcccaa gctcctgatc tattctgcat ccactctggc
atctggggtc 240 ccatcgcgat tcaaaggcag tggatctggg acagactaca
ctctcaccat cagcggcgtg 300 cagcgtgagg atgctgccac ctactactgt
ctaggtagtt atagtaatac tattaggaca 360 ttcggagctg gcaccaaggt
agaaatcaaa cgtacg 396 <210> SEQ ID NO 120 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 120 Thr Tyr Asp Ile Asn 1 5 <210> SEQ
ID NO 121 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 121 Tyr Ile
Tyr Arg Gly Ser Pro Tyr Tyr Ala Asp Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 122 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 122 Asn Leu Tyr Ser Val Asn Val Leu 1 5 <210> SEQ
ID NO 123 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 123 Gln Ala
Ser Gln Ser Ile Ser Ser Arg Leu Ala 1 5 10 <210> SEQ ID NO
124 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 124 Ser Ala
Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO 125 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 125 Leu Gly Ser Tyr Ser Asn Thr Ile
Arg Thr 1 5 10 <210> SEQ ID NO 126 <211> LENGTH: 115
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 126 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu
Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser
Gly Ile Asp Leu Ser Asp Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Val Tyr Asp
Ile Gly Thr Ile Tyr Tyr Ala Pro Trp Ala Glu Gly 50 55 60 Arg Phe
Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Lys Met Ser 65 70 75 80
Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Thr Glu Ala 85
90 95 Pro Gly Tyr Ser Asp Gly Asp Ile Trp Gly Pro Gly Thr Leu Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 127
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 127 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcgctggagg agtccggggg tcgcctggta acgcctggag gatccctgac actcacctgc
120 acagtctctg gaatcgacct cagtgactac gacatgagct gggtccgcca
ggctccaggg 180 aaggggctgg aatggatcgg aatcgtgtat gatattggta
ccatatatta tgcgccctgg 240 gcggaaggcc gattcaccat ctccaaaacc
tcgaccacga tggatctgaa aatgagcagt 300 ctgacaaccg aggacacggc
cacttatttc tgtgccacag aggctcctgg atatagtgat 360 ggggatatct
ggggcccagg caccctggtc accgtctcga gt 402 <210> SEQ ID NO 128
<211> LENGTH: 110 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 128 Leu Val Met Thr Gln
Thr Pro Ser Ser Val Ser Ala Ala Val Gly Gly 1 5 10 15 Thr Val Thr
Ile Asn Cys Gln Ala Ser Glu Thr Val Gly Asn Asn Asn 20 25 30 Arg
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40
45 Ile Tyr Gly Ala Ala Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys
50 55 60 Gly Ser Gly Ser Gly Ala His Phe Thr Leu Thr Ile Ser Asn
Val Gln 65 70 75 80 Arg Glu Asp Val Ala Thr Tyr Val Cys Gly Gly Tyr
Lys Asp Ser Thr 85 90 95 Asp Val Gly Phe Gly Gly Gly Thr Glu Leu
Glu Ile Leu Arg 100 105 110 <210> SEQ ID NO 129 <211>
LENGTH: 399 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 129 atggacacga gggcccccac
tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60 acatttgccc
tggtgatgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca 120
gtcaccatca attgccaggc cagtgagact gttggtaata acaaccgctt atcgtggtat
180 caacagaaac cagggcagcc tcccaagctc ctgatctatg gtgcagccac
tctggcatct 240 ggggtcccat cgcggttcaa aggcagtgga tctggggcac
acttcactct caccatcagc 300 aacgtgcagc gtgaggatgt tgccacctac
gtctgtggag gttataaaga tagtactgat 360 gttggttttg gcggagggac
cgagctggag atcctacgt 399 <210> SEQ ID NO 130 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 130 Asp Tyr Asp Met Ser 1 5
<210> SEQ ID NO 131 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 131 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp
Ala Glu Gly 1 5 10 15 <210> SEQ ID NO 132 <211> LENGTH:
10 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 132 Glu Ala Pro Gly Tyr Ser Asp Gly
Asp Ile 1 5 10 <210> SEQ ID NO 133 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 133 Gln Ala Ser Glu Thr Val Gly Asn Asn Asn
Arg Leu Ser 1 5 10 <210> SEQ ID NO 134 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 134 Gly Ala Ala Thr Leu Ala Ser 1 5
<210> SEQ ID NO 135 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 135 Gly Gly Tyr Lys Asp Ser Thr Asp Val Gly 1 5 10
<210> SEQ ID NO 136 <211> LENGTH: 119 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 136 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser
Leu Ser Thr Tyr Thr 20 25 30 Met Asn Trp Val Arg Gln Ser Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ala Ile Ser Tyr Asp Gly Gly
Thr Ala Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Thr Thr Val Asp Leu Gln Ile Ala 65 70 75 80 Ser Pro Thr
Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Phe 85 90 95 Tyr
Val Tyr Ala Tyr Ile Gly Asp Ala Phe Asp Pro Trp Gly Pro Gly 100 105
110 Thr Leu Val Thr Val Ser Ser 115 <210> SEQ ID NO 137
<211> LENGTH: 414 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 137 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagtctctg gattctccct cagtacctat acaatgaact gggtccgcca
gtctccaggg 180 aaggggctgg aatggatcgg agccattagt tatgatggtg
gcacagccta cgcgaactgg 240 gcgaaaggcc gattcaccat ctccaaaacc
tcgaccacgg tggatctgca aatcgccagt 300 ccgacaaccg aggacacggc
cacctatttc tgtgccagag gtttttatgt ttatgcttat 360 attggggatg
ctttcgatcc ctggggccca ggcaccctgg tcaccgtctc gagt 414 <210>
SEQ ID NO 138 <211> LENGTH: 112 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
138 Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Thr Val Gly Gly
1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Thr Val Tyr Lys
Asn Asn 20 25 30 Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro
Pro Lys Leu Leu 35 40 45 Ile Tyr Leu Ala Ser Thr Leu Ala Ser Gly
Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe
Thr Leu Thr Ile Ser Gly Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr
Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp Asp 85 90 95 Ala Asp Thr Ala
Phe Gly Gly Gly Thr Glu Val Val Val Val Arg Thr 100 105 110
<210> SEQ ID NO 139 <211> LENGTH: 405 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 139 atggacacga gggcccccac tcagctgctg gggctcctgc
tggtctggct cccaggtgcc 60 acatttgcag ccgtgctgac ccagacacca
tcgcccgtgt ctgcaactgt gggaggcact 120 gtcaccatca agtgccagtc
cagtcagact gtttataaaa acaacctctt atcctggtat 180 cagcagaaac
ccgggcagcc tcccaagctc ctgatctatc tggcatccac tctggcatct 240
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc
300 ggcgtgcagt gtgacgatgc tgccacttac tactgtctag gcggttatga
tgatgacgct 360 gatactgctt tcggcggagg gaccgaggtg gtggtggtcc gtacg
405 <210> SEQ ID NO 140 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 140 Thr Tyr Thr Met Asn 1 5 <210> SEQ ID NO 141
<211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 141 Ala Ile Ser Tyr Asp
Gly Gly Thr Ala Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210>
SEQ ID NO 142 <211> LENGTH: 14 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
142 Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp Ala Phe Asp Pro 1 5 10
<210> SEQ ID NO 143 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 143 Gln Ser Ser Gln Thr Val Tyr Lys Asn Asn Leu Leu Ser 1
5 10 <210> SEQ ID NO 144 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 144 Leu Ala Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
145 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 145 Leu Gly
Gly Tyr Asp Asp Asp Ala Asp Thr Ala 1 5 10 <210> SEQ ID NO
146 <211> LENGTH: 120 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 146 Gln Ser
Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Val Tyr Pro 20
25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gly Trp Ile
Gly 35 40 45 Ile Ile Asn Asp Val Asp Asp Thr Ala Tyr Ser Ala Trp
Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr
Val Asp Leu Lys Ile 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala
Thr Tyr Phe Cys Ala Arg Gly 85 90 95 Tyr Leu Ser Tyr Ala Tyr Ala
Gly Asp Ala Phe Asp Pro Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr
Val Ser Ser 115 120 <210> SEQ ID NO 147 <211> LENGTH:
417 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 147 atggagactg ggctgcgctg
gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg
agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc 120
acagtctctg gattctccct cagtgtatat ccaataaact gggtccgcca ggctccaggg
180 aaggggctgg gatggatcgg gattattaat gatgttgatg acacagccta
ctcagcctgg 240 gcgaaaggcc gattcaccat ctccaaagcc tcgtcgacca
cggtggattt gaaaatcacc 300 agtccgacaa ccgaagacac ggccacctat
ttctgtgcca gaggttattt gagttatgct 360 tatgctggag atgctttcga
tccctggggc ccaggcaccc tggtcaccgt ctcgagt 417 <210> SEQ ID NO
148 <211> LENGTH: 110 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 148 Ala Val
Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 1 5 10 15
Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Ile Tyr Asn Asn Asn 20
25 30 Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu
Leu 35 40 45 Ile His Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr
Ile Ser Gly Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys
Leu Gly Gly Tyr Asp Asp Asp 85 90 95 Ala Asp Thr Ala Phe Gly Gly
Gly Thr Glu Val Val Val Val 100 105 110 <210> SEQ ID NO 149
<211> LENGTH: 405 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 149 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
acatttgcag ccgtgctgac ccagacacca tcgcccgtgt ctgcagctgt gggaggcaca
120 gtcaccatca agtgccagtc cagtcagagt atttataata acaacctctt
atcctggtat 180 cagcagaaac cagggcagcc tcccagactc ctgatccatt
ttgcatccac tctggcatct 240 ggggtcccag ataggttcag cggcagtgga
tctgggacac agttcactct caccatcagc 300 ggcgtacagt gtgacgatgc
tgccacttat tactgtctag gcggttatga tgatgatgct 360 gatactgctt
tcggcggagg gaccgaggtg gtggtcgtcc gtacg 405 <210> SEQ ID NO
150 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 150 Val Tyr
Pro Ile Asn 1 5 <210> SEQ ID NO 151 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 151 Ile Ile Asn Asp Val Asp Asp Thr Ala Tyr
Ser Ala Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 152
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 152 Gly Tyr Leu Ser Tyr
Ala Tyr Ala Gly Asp Ala Phe Asp Pro 1 5 10 <210> SEQ ID NO
153 <211> LENGTH: 13 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 153 Gln Ser
Ser Gln Ser Ile Tyr Asn Asn Asn Leu Leu Ser 1 5 10 <210> SEQ
ID NO 154 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 154 Phe Ala
Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO 155 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 155 Leu Gly Gly Tyr Asp Asp Asp Ala
Asp Thr Ala 1 5 10 <210> SEQ ID NO 156 <211> LENGTH:
114 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 156 Gln Glu Leu Lys Glu Ser Gly Gly
Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Ser Cys Thr
Ala Ser Gly Leu Thr Leu Gly Ser Tyr Ser 20 25 30 Met Thr Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 35 40 45 Val Ile
Gly Val Gly Gly Thr Leu Asn Tyr Ala Ser Trp Ala Gln Gly 50 55 60
Arg Phe Thr Ile Ser Lys Pro Ser Ser Thr Thr Val Asp Leu Lys Met 65
70 75 80 Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Arg Gly 85 90 95 Thr Tyr Ser Gly Asp Ser Ile Trp Gly Pro Gly Thr
Leu Val Thr Val 100 105 110 Ser Ser <210> SEQ ID NO 157
<211> LENGTH: 399 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 157 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccaatgtcag 60
gagctgaagg agtccggggg tcgcctggtc acgcctgggg gatccctgac actctcctgc
120 actgcctctg gactcaccct tggtagttat tcaatgacct gggtccgcca
ggctccaggg 180 aaggggctgg aatggatggg agtcattggt gttggtggta
ccctaaacta cgcgagctgg 240 gcgcaaggcc gattcaccat ctccaaaccc
tcgtcgacca cggtggatct gaaaatgacc 300 agtctgacaa ccgaggacac
ggccacctat ttctgtgcca gaggcactta tagtggtgat 360 agtatctggg
gcccaggcac cctggtcacc gtctcgagt 399 <210> SEQ ID NO 158
<211> LENGTH: 131 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 158 Met Asp Thr Arg Ala
Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 Leu Pro Gly
Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Ser Ser 20 25 30 Thr
Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 35 40
45 Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
50 55 60 Pro Pro Lys Pro Leu Ile Val Arg Ala Ser Ile Leu Thr Ser
Gly Val 65 70 75 80 Pro Ser Arg Phe Lys Gly Ser Arg Ser Gly Thr Glu
Tyr Thr Leu Thr 85 90 95 Ile Ser Gly Val Gln Arg Glu Asp Ala Ala
Thr Tyr Tyr Cys Leu Gly 100 105 110 Gly Asp Gly His Val Ser Asn Phe
Gly Gly Gly Thr Glu Leu Glu Ile 115 120 125 Leu Arg Thr 130
<210> SEQ ID NO 159 <211> LENGTH: 393 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 159 atggacacga gggcccccac tcagctgctg gggctcctgc
tgctctggct cccaggtgcc 60 agatgtgatg ttgtgatgac ccagactcca
tcctccacgt ctgcagctgt gggaggcaca 120 gtcaccatca agtgccaggc
cagtcagagc attagtagtt ggttggcctg gtatcaacag 180 aaaccagggc
agcctcccaa gcccctgatc gtcagagcgt ccattctgac atctggggtc 240
ccatcgcggt tcaaaggcag tagatctggg acagagtaca ctctcaccat cagcggcgtg
300 cagcgtgagg atgctgccac ctactactgt ctaggtggtg atggtcatgt
ttctaatttc 360 ggcggaggga ccgagctgga gatcctacgt acg 393 <210>
SEQ ID NO 160 <211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
160 Thr Ala Ser Gly Leu Thr Leu Gly Ser Tyr Ser Met Thr 1 5 10
<210> SEQ ID NO 161 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 161 Val Ile Gly Val Gly Gly Thr Leu Asn Tyr Ala Ser Trp
Ala Gln 1 5 10 15 <210> SEQ ID NO 162 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 162 Gly Thr Tyr Ser Gly Asp Ser Ile 1 5
<210> SEQ ID NO 163 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 163 Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 1 5 10
<210> SEQ ID NO 164 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 164 Arg Ala Ser Ile Leu Thr Ser 1 5 <210> SEQ ID NO
165 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 165 Leu Gly
Gly Asp Gly His Val Ser Asn 1 5 <210> SEQ ID NO 166
<211> LENGTH: 117 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 166 Gln Ser Val Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu
Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Gly Tyr Thr 20 25 30 Met
Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 35 40
45 Ile Ile Ser Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Val Lys Gly
50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys
Met Ile 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Arg Gly Ser 85 90 95 Gly Ala Tyr Ile Ser Asp Tyr Phe Asn Val
Trp Gly Pro Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 167 <211> LENGTH: 408 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 167 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc
tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc
acgcctggga cacccctgac actcacctgc 120 gcagtctctg gattctccct
cagtggctat acaatgatct gggtccgcca ggctccaggg 180 gaggggctgg
aatggatcgg aatcattagt agtagtggta acacatacta cgcgagctgg 240
gtgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatgattagt
300 ccgacaaccg aggacacggc cacctatttc tgtgccagag gtagtggtgc
ttatatttct 360 gactacttta acgtctgggg cccaggcacc ctggtcaccg tctcgagt
408 <210> SEQ ID NO 168 <211> LENGTH: 109 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 168 Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Glu Ala Ala
Val Glu Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser
Ile Asp Ser Trp Leu 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Ala Ser Lys Leu Ala Pro
Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Gln
Phe Thr Leu Thr Ile Gly Asp Leu Glu Cys Ala 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Val Asn Ala Gly 85 90 95 Tyr
Gly Phe Gly Gly Gly Thr Glu Val Val Val Val Arg 100 105 <210>
SEQ ID NO 169 <211> LENGTH: 396 <212> TYPE: DNA
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
169 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgcat tcgaattgac ccagactcca tcctccgtgg
aggcagctgt ggaaggcaca 120 gtcaccatca agtgccaggc cagtcagagc
attgatagtt ggttatcctg gtatcagcag 180 aaaccagggc agcctcccaa
gctcctgatc tattctgcat ccaaactggc acctggggtc 240 ccatcgcggt
tcagcggcag tggatctggg acacagttca ctctcaccat cggcgacctg 300
gagtgtgccg atgctgccac ttactactgt caaagctatt atgatgttaa tgctggttat
360 ggtttcggcg gagggaccga ggtggtggtc gtccgt 396 <210> SEQ ID
NO 170 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 170 Gly Tyr
Thr Met Ile 1 5 <210> SEQ ID NO 171 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 171 Ile Ile Ser Ser Ser Gly Asn Thr Tyr Tyr
Ala Ser Trp Val Lys Gly 1 5 10 15 <210> SEQ ID NO 172
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 172 Gly Ser Gly Ala Tyr
Ile Ser Asp Tyr Phe Asn Val 1 5 10 <210> SEQ ID NO 173
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 173 Gln Ala Ser Gln Ser
Ile Asp Ser Trp Leu Ser 1 5 10 <210> SEQ ID NO 174
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 174 Ser Ala Ser Lys Leu
Ala Pro 1 5 <210> SEQ ID NO 175 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 175 Gln Ser Tyr Tyr Asp Val Asn Ala Gly Tyr
Gly 1 5 10 <210> SEQ ID NO 176 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 176 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu
Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser
Gly Phe Ser Leu Ser Ser Tyr Thr 20 25 30 Met Ile Trp Val Arg Gln
Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Ala
Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn Gly 50 55 60 Arg Phe
Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80
Ser Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 85
90 95 Gly Thr Tyr Thr Ser Asp Tyr Phe Asn Ile Trp Gly Pro Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 177
<211> LENGTH: 408 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 177 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagtctctg gattctccct cagtagctat acaatgatct gggtccgcca
ggctccaggg 180 gaggggctgg aatggatcgg aatcattagt gctggtggta
gcgcatacta cgcgagctgg 240 gtgaatggcc gattcaccat ctccaaaacc
tcgaccacgg tggatctgaa aatgaccagt 300 ccgacaaccg gggacacggc
cacctatttc tgtgccagag gtagtggtac ttatacttcc 360 gactacttta
acatctgggg cccaggcacc ctggtcaccg tctcgagt 408 <210> SEQ ID NO
178 <211> LENGTH: 109 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 178 Phe Glu
Leu Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val Gly Gly 1 5 10 15
Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu 20
25 30 Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
Tyr 35 40 45 Ser Ala Ser Lys Leu Ala Thr Gly Val Pro Ser Arg Phe
Ser Gly Ser 50 55 60 Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser
Asp Leu Glu Cys Ala 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Ser
Tyr Tyr Asp Ala Asn Ala Gly 85 90 95 Tyr Gly Phe Gly Gly Gly Thr
Lys Val Val Val Val Arg 100 105 <210> SEQ ID NO 179
<211> LENGTH: 396 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 179 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
agatgtgcat tcgaattgac ccagactcca tcctccgtgg aggcagctgt gggaggcaca
120 gtcaccatca aatgccaggc cagtcagagc attgatagtt ggttagcctg
gtatcagcag 180 aaaccagggc agcctcccaa gctcctgatc tattctgcat
ccaaactggc aactggggtc 240 ccatcgcggt tcagcggcag tggatctggg
acacagttca ctctcaccat cagcgacctg 300 gagtgtgccg atgctgccac
ttactactgt caaagttatt atgatgctaa tgctggttat 360 ggtttcggcg
gagggaccaa ggtggtggtg gtccgt 396 <210> SEQ ID NO 180
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 180 Ser Tyr Thr Met Ile
1 5 <210> SEQ ID NO 181 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 181 Ile Ile Ser Ala Gly Gly Ser Ala Tyr Tyr Ala Ser Trp
Val Asn Gly 1 5 10 15 <210> SEQ ID NO 182 <211> LENGTH:
12 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 182 Gly Ser Gly Thr Tyr Thr Ser Asp
Tyr Phe Asn Ile 1 5 10 <210> SEQ ID NO 183 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 183 Gln Ala Ser Gln Ser Ile Asp Ser
Trp Leu Ala 1 5 10 <210> SEQ ID NO 184 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 184 Ser Ala Ser Lys Leu Ala Thr 1 5
<210> SEQ ID NO 185 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 185 Gln Ser Tyr Tyr Asp Ala Asn Ala Gly Tyr Gly 1 5 10
<210> SEQ ID NO 186 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 186 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser
Leu Ser Asp Tyr Thr 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly
Glu Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Ser Ser Gly Asn
Thr Tyr Tyr Ala Thr Trp Val Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Thr Thr Val Asp Leu Lys Met Ile 65 70 75 80 Ser Pro Thr
Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Gly
Ala Tyr Ile Ser Asp Tyr Phe Asn Val Trp Gly Pro Gly Thr Leu 100 105
110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 187 <211>
LENGTH: 408 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 187 atggagactg ggctgcgctg
gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg
agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc 120
gcagtctctg gattctccct cagtgactat acaatgatct gggtccgcca ggctccaggg
180 gaggggctgg aatggatcgg aatcattagt agtagtggta acacatacta
cgcgacctgg 240 gtgaaaggcc gattcaccat ctccaaaacc tcgaccacgg
tggatctgaa aatgattagt 300 ccgacaaccg aggacacggc cacctatttc
tgtgccagag gtagtggtgc ttatatttct 360 gactacttta acgtctgggg
cccaggcacc ctggtcaccg tctcgagt 408 <210> SEQ ID NO 188
<211> LENGTH: 109 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 188 Phe Glu Leu Thr Gln
Thr Pro Ser Ser Val Glu Ala Ala Val Glu Gly 1 5 10 15 Thr Val Thr
Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu 20 25 30 Ser
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 35 40
45 Ala Ala Ser Lys Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60 Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Gly Asp Leu Glu
Cys Ala 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp
Val Asn Ala Gly 85 90 95 Tyr Gly Phe Gly Gly Gly Thr Glu Val Val
Val Val Arg 100 105 <210> SEQ ID NO 189 <211> LENGTH:
396 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 189 atggacacga gggcccccac
tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60 agatgtgcat
tcgaattgac ccagactcca tcctccgtgg aggcagctgt ggaaggcaca 120
gtcaccatca agtgccaggc cagtcagagc attgatagtt ggttatcctg gtatcagcag
180 aaaccagggc agcctcccaa gctcctgatc tatgctgcat ccaaactggc
aactggggtc 240 ccatcgcggt tcagcggcag tggatctggg acacagttca
ctctcaccat cggcgacctg 300 gagtgtgccg atgctgccac ttactactgt
caaagctatt atgatgttaa tgctggttat 360 ggtttcggcg gagggaccga
ggtggtggtc gtccgt 396 <210> SEQ ID NO 190 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 190 Asp Tyr Thr Met Ile 1 5 <210> SEQ
ID NO 191 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 191 Ile Ile
Ser Ser Ser Gly Asn Thr Tyr Tyr Ala Thr Trp Val Lys Gly 1 5 10 15
<210> SEQ ID NO 192 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 192 Gly Ser Gly Ala Tyr Ile Ser Asp Tyr Phe Asn Val 1 5
10 <210> SEQ ID NO 193 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 193 Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu Ser 1 5 10
<210> SEQ ID NO 194 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 194 Ala Ala Ser Lys Leu Ala Thr 1 5 <210> SEQ ID NO
195 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 195 Gln Ser
Tyr Tyr Asp Val Asn Ala Gly Tyr Gly 1 5 10 <210> SEQ ID NO
196 <211> LENGTH: 121 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 9C8 VH AA
<400> SEQUENCE: 196 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val
Ser Gly Ile Asp Leu Ser Ser Tyr 20 25 30 Asp Leu Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Tyr Ile Tyr
Thr Asp Ser Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85
90 95 Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 197 <211> LENGTH: 363 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 9C8 VH
nt <400> SEQUENCE: 197 gaggtgcagc tggtggagtc tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggaat
cgacctcagt agctacgacc tcagctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgggctac atttatactg atagtagcac atactacgcg 180
aactgggcga agggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg
240 caactcaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtagtacc 300 gattatgctt tcgacactcg gttggatctc tggggccagg
gcaccctggt caccgtctcg 360 agc 363 <210> SEQ ID NO 198
<211> LENGTH: 110 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 9C8 VL AA <400>
SEQUENCE: 198 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val
Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
<210> SEQ ID NO 199 <211> LENGTH: 330 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 9C8 VL
nt <400> SEQUENCE: 199 gacatccagc tcacccagtc tccatcctct
gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagg acatccactc tggcatctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggaaatcaaa 330 <210> SEQ
ID NO 200 <211> LENGTH: 32 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
scFv-NotF <400> SEQUENCE: 200 gcgatagcgg ccgcaccacc
atggaggctc cc 32 <210> SEQ ID NO 201 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer JHXhoR <400> SEQUENCE: 201
gctatactcg agacggtgac cagggtgccc tggcccc 37 <210> SEQ ID NO
202 <211> LENGTH: 53 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
DPK8F1 <400> SEQUENCE: 202 gacatccagt tgacccagtc tccatccttt
ctgtctgcat ctgtaggaga cag 53 <210> SEQ ID NO 203 <211>
LENGTH: 32 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer DPK8-AgeF <400>
SEQUENCE: 203 gacacaaccg gtgacatcca gttgacccag tc 32 <210>
SEQ ID NO 204 <211> LENGTH: 48 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 9C8-H1F <400> SEQUENCE: 204 gaatcgacct cagtagctac
gacatgagct gggtccgtca ggcacctg 48 <210> SEQ ID NO 205
<211> LENGTH: 47 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 9C8-H1R1
<400> SEQUENCE: 205 gtagctactg aggtcgattc cagaagctgc
acaggagagg cgcaggg 47 <210> SEQ ID NO 206 <211> LENGTH:
47 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 9C8-H1R2 <400> SEQUENCE: 206
gtagctactg aggtcgattc cagagacagt acaggagagg cgcaggg 47 <210>
SEQ ID NO 207 <211> LENGTH: 53 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 9C8-H2F <400> SEQUENCE: 207 actgatagta gcacatacta
cgcgaactgg gcgaagggcc gcttcaccat cag 53 <210> SEQ ID NO 208
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 9C8-H2R
<400> SEQUENCE: 208 gcgtagtatg tgctactatc agtataaatg
tagctcaccc actccagacc c 51 <210> SEQ ID NO 209 <211>
LENGTH: 53 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 9C8-H3R1 <400>
SEQUENCE: 209 gtgtcgaaag cataatcggt actacctctg gcgcagtaat
acaccgcggt gtc 53 <210> SEQ ID NO 210 <211> LENGTH: 53
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 9C8-H3R2 <400> SEQUENCE: 210
gaccagggtg ccctggcccc agagatccaa ccgagtgtcg aaagcataat cgg 53
<210> SEQ ID NO 211 <211> LENGTH: 38 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 13A8-L2F <400> SEQUENCE: 211 gggcatccac tctgacatct
ggagtcccat caaggttc 38 <210> SEQ ID NO 212 <211>
LENGTH: 36 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 13A8-L2R <400>
SEQUENCE: 212 gactccagat gtcagagtgg atgccctata gatcag 36
<210> SEQ ID NO 213 <211> LENGTH: 21 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 13A8-H2F <400> SEQUENCE: 213 gcacatggta cgcgaactgg g
21 <210> SEQ ID NO 214 <211> LENGTH: 27 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer 13A8-H2R <400> SEQUENCE: 214
agttcgcgta ccatgtgcta ctatcag 27 <210> SEQ ID NO 215
<211> LENGTH: 27 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 13A8-EcoF
<400> SEQUENCE: 215 gggacagaat tcactctcac aatcagc 27
<210> SEQ ID NO 216 <211> LENGTH: 28 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 13A8-EcoR <400> SEQUENCE: 216 gagagtgaat tctgtcccag
atccactg 28 <210> SEQ ID NO 217 <211> LENGTH: 49
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-L1F <400> SEQUENCE:
217 gccagtgagg acatcgagag ctacctggct tggtatcagc aaaaaccag 49
<210> SEQ ID NO 218 <211> LENGTH: 46 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-L1R <400> SEQUENCE: 218 agctctcgat gtcctcactg
gcctggcaag tgatggtgac tctgtc 46 <210> SEQ ID NO 219
<211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-L2F
<400> SEQUENCE: 219 agtgcatcca ctctgacctc tggcgtccca
tcaaggttca gc 42 <210> SEQ ID NO 220 <211> LENGTH: 40
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-L2R <400> SEQUENCE:
220 agaggtcaga gtggatgcac tatagatcag gagcttaggg 40 <210> SEQ
ID NO 221 <211> LENGTH: 50 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
31A12-L3F <400> SEQUENCE: 221 gtctcggtgc tgacgatacc
actaccgtct tcggcggagg gaccaaggtg 50 <210> SEQ ID NO 222
<211> LENGTH: 47 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-L3R
<400> SEQUENCE: 222 agtggtatcg tcagcaccga gacagtaata
agttgcaaaa tcttcag 47 <210> SEQ ID NO 223 <211> LENGTH:
49 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-H1F <400> SEQUENCE:
223 ggattcagcc tcagttccta ttggatgacc tgggtccgtc aggcacctg 49
<210> SEQ ID NO 224 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-H1R <400> SEQUENCE: 224 ataggaactg aggctgaatc
cagaggctgt acaggagagg cgcagggac 49 <210> SEQ ID NO 225
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-H2F
<400> SEQUENCE: 225 agctccacat actatgcatc ttgggcgaaa
ggccgcttca ccatcagccg c 51 <210> SEQ ID NO 226 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 31A12-H2R <400>
SEQUENCE: 226 gatgcatagt atgtggagct ggtagcaata gtgcccaccc
actccaaacc c 51 <210> SEQ ID NO 227 <211> LENGTH: 50
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-H3R1 <400> SEQUENCE:
227 agagatctaa gtcatagtct gtagtgagtc ctctggcgca gtaatacacc 50
<210> SEQ ID NO 228 <211> LENGTH: 55 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-HxhoR <400> SEQUENCE: 228 gaccgctcga gacggtgacc
agggtgccct ggccccagag atctaagtca tagtc 55 <210> SEQ ID NO 229
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-L1F
<400> SEQUENCE: 229 agagtattta taataacaac ctcttatcct
ggtatcagca aaaaccaggg 50 <210> SEQ ID NO 230 <211>
LENGTH: 54 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-L1R <400>
SEQUENCE: 230 ggataagagg ttgttattat aaatactctg actggactgg
caagtgatgg tgac 54 <210> SEQ ID NO 231 <211> LENGTH: 39
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 45G5-L2F <400> SEQUENCE: 231
gcatccactc tggcatctgg cgtcccatca aggttcagc 39 <210> SEQ ID NO
232 <211> LENGTH: 43 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
45G5-L2R <400> SEQUENCE: 232 gccagatgcc agagtggatg caaaatagat
caggagctta ggg 43 <210> SEQ ID NO 233 <211> LENGTH: 51
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 45G5-L3F <400> SEQUENCE: 233
ggcggttatg atgatgatgc tgatactgct ttcggcggag ggaccaaggt g 51
<210> SEQ ID NO 234 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-L3R <400> SEQUENCE: 234 gcatcatcat cataaccgcc
tagacagtaa taagttgcaa aatcttcag 49 <210> SEQ ID NO 235
<211> LENGTH: 49 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-H1F
<400> SEQUENCE: 235 ggattctccc tcagtgtata tccaataaac
tgggtccgtc aggcacctg 49 <210> SEQ ID NO 236 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-H1R <400>
SEQUENCE: 236 gatatacact gagggagaat ccagagactg tacaggagag
gcgcagggac 50 <210> SEQ ID NO 237 <211> LENGTH: 54
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 45G5-H2F <400> SEQUENCE: 237
gttgatgaca cagcctactc agcctgggcg aaaggccgct tcaccatcag ccgc 54
<210> SEQ ID NO 238 <211> LENGTH: 54 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-H2R <400> SEQUENCE: 238 gagtaggctg tgtcatcaac
atcattaata atgcccaccc actccaaacc cttg 54 <210> SEQ ID NO 239
<211> LENGTH: 52 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-H3R1
<400> SEQUENCE: 239 agcatctcca gcataagcat aactcaaata
acctctggcg cagtaataca cc 52 <210> SEQ ID NO 240 <211>
LENGTH: 53 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-H3R2 <400>
SEQUENCE: 240 acggtgacca gggtgccctg gccccaggga tcgaaagcat
ctccagcata agc 53 <210> SEQ ID NO 241 <211> LENGTH: 50
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 22H8-L1F <400> SEQUENCE: 241
agactgtcta taagaacaac ctcttatcct ggtatcagca aaaaccaggg 50
<210> SEQ ID NO 242 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-L1R <400> SEQUENCE: 242 ggttgttctt atagacagtc
tgactggact ggcaagtgat ggtgactctg 50 <210> SEQ ID NO 243
<211> LENGTH: 48 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-L2F
<400> SEQUENCE: 243 gatctatctg gcatccactc tggcatctgg
cgtcccatca aggttcag 48 <210> SEQ ID NO 244 <211>
LENGTH: 40 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 22H8-L2R <400>
SEQUENCE: 244 agatgccaga gtggatgcca gatagatcag gagcttaggg 40
<210> SEQ ID NO 245 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-L3F <400> SEQUENCE: 245 aggcggttat gatgatgacg
ctgatactgc tttcggcgga gggaccaagg tg 52 <210> SEQ ID NO 246
<211> LENGTH: 49 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-L3R
<400> SEQUENCE: 246 gcgtcatcat cataaccgcc tagacagtaa
taagttgcaa aatcttcag 49 <210> SEQ ID NO 247 <211>
LENGTH: 49 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 22H8-H1F <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(25)..(25) <223> OTHER INFORMATION: n is a, c, g, or t
<400> SEQUENCE: 247 ggattctccc tcagtaccta tacantgaac
tgggtccgtc aggcacctg 49 <210> SEQ ID NO 248 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 22H8-H1R <400>
SEQUENCE: 248 gtataggtac tgagggagaa tccagagact gtacaggaga
ggcgcaggga c 51 <210> SEQ ID NO 249 <211> LENGTH: 53
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 22H8-H2F <400> SEQUENCE: 249
atggtggcac agcctacgcg aactgggcga aaggccgctt caccatcagc cgc 53
<210> SEQ ID NO 250 <211> LENGTH: 51 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-H2R <400> SEQUENCE: 250 gcgtaggctg tgccaccatc
ataactaatg gcgcccaccc actccaaacc c 51 <210> SEQ ID NO 251
<211> LENGTH: 55 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-H3R1
<400> SEQUENCE: 251 gaaagcatcc ccaatataag cataaacata
aaaacctctg gcgcagtaat acacc 55 <210> SEQ ID NO 252
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-H3R2
<400> SEQUENCE: 252 ggtgaccagg gtgccctggc cccagggatc
gaaagcatcc ccaatataag c 51 <210> SEQ ID NO 253 <211>
LENGTH: 32 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer H82XR <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: n is a, c, g, or t
<400> SEQUENCE: 253 gcaggctgtt ganttgcaga tacagggtgt tc 32
<210> SEQ ID NO 254 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer H82XF <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (9)..(9) <223> OTHER
INFORMATION: n is a, c, g, or t <400> SEQUENCE: 254
atctgcaant caacagcctg cgtgccgagg ac 32 <210> SEQ ID NO 255
<211> LENGTH: 53 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer DPK8gsR1
<400> SEQUENCE: 255 gccgctaccg ccaccaccag aaccgccacc
gcctttgatt tccaccttgg tcc 53 <210> SEQ ID NO 256 <211>
LENGTH: 56 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer DPK8gsR2 <400>
SEQUENCE: 256 ctgcacctcg gatccgcccc ctccggaacc accgccgccg
ctaccgccac caccag 56 <210> SEQ ID NO 257 <211> LENGTH:
28 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer DP427BamF <400> SEQUENCE:
257 gggcggatcc gaggtgcagc tggtggag 28 <210> SEQ ID NO 258
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer DPK8scfvR
<400> SEQUENCE: 258 accgcctttg atttccacct tggtccctcc gccgaa
36 <210> SEQ ID NO 259 <211> LENGTH: 121 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 13A8 VH AA <400> SEQUENCE: 259 Glu Val Gln Leu Val
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 20 25 30 Asp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40
45 Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp Ala Lys
50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr
Arg Leu Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser
Ser 115 120 <210> SEQ ID NO 260 <211> LENGTH: 363
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 13A8 VH nt <400> SEQUENCE: 260 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag tctctggaat cgacctcagt agctacgaca tgagctgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggctac atttatactg atagtagcac
atggtacgcg 180 aactgggcga agggccgctt caccatcagc cgcgacaact
ccaagaacac cctgtatctg 240 caaatgaaca gcctgcgtgc cgaggacacc
gcggtgtatt actgcgccag aggtagtacc 300 gattatgctt tcgacactcg
gttggatctc tggggccagg gcaccctggt caccgtctcg 360 agc 363 <210>
SEQ ID NO 261 <211> LENGTH: 110 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 13A8
VL AA <400> SEQUENCE: 261 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala
Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70
75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn
Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 <210> SEQ ID NO 262 <211> LENGTH: 330
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 13A8 VL nt <400> SEQUENCE: 262 gacatccagt
tgacccagtc tccatccttt ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtca gagcattagc aatgaattat cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctatagg gcatccactc tgacatctgg
agtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag
ggttataata gtaatgatgt tgataatgtt 300 ttcggcggag ggaccaaggt
ggaaatcaaa 330 <210> SEQ ID NO 263 <211> LENGTH: 124
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 28D2 VH AA <400> SEQUENCE: 263 Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Ser Leu Ser Lys Asn 20
25 30 Ala Ile Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr Tyr Ala Ser
Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Tyr Ala Gly Asp Ser
Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp 100 105 110 Leu Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID NO 264
<211> LENGTH: 372 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 28D2 VH nt <400>
SEQUENCE: 264 gaggtgcagc tggtggagtc tggcggtggc ttggtacagc
cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggatt atccctcagt
aagaatgcaa ttgcctgggt ccgtcaggca 120 cctggcaagg gtttggagtg
ggtgggcatc atttatgctg gtggtgccac aacctacgcg 180 agctgggcga
aaggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg 240
caaatgaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag agaatatgct
300 ggtgatagtt attatactgg atacactcag ttggatctct ggggccaggg
caccctggtc 360 accgtctcga gc 372 <210> SEQ ID NO 265
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 28D2 VL AA <400>
SEQUENCE: 265 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu
Asp Leu Phe Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr 85 90 95 Pro
Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105
110 <210> SEQ ID NO 266 <211> LENGTH: 336 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 28D2 VL nt <400> SEQUENCE: 266 gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtga ggaccttttt agtagtttgg cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg
ggtcccatca 180 aggttcagcg gcagtggatc tgggacagac ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctaggc
ctttactatt atcttactcc tgatcctatt 300 tatgggttcg gcggagggac
caaggtggaa atcaaa 336 <210> SEQ ID NO 267 <211> LENGTH:
117 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 31A12 VH AA <400> SEQUENCE: 267 Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20
25 30 Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp
Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Gly Leu Thr Thr Asp Tyr Asp
Leu Asp Leu Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 <210> SEQ ID NO 268 <211> LENGTH: 350 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 31A12 VH nt <400> SEQUENCE: 268 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag cctctggatt cagcctcagt tcctattgga tgacctgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggcact attgctacca gctccacata
ctatgcatct 180 tgggcgaaag gccgcttcac catcagccgc gacaactcca
agaacaccct gtatctgcaa 240 atgaacagcc tgcgtgccga ggacaccgcg
gtgtattact gcgccagagg actcactaca 300 gactatgact tagatctctg
gggccagggc accctggtca ccgtctcgac 350 <210> SEQ ID NO 269
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 31A12 VL AA <400>
SEQUENCE: 269 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu
Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Thr
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr Thr Thr 85 90 95 Val
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> SEQ ID
NO 270 <211> LENGTH: 321 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 31A12 VL nt
<400> SEQUENCE: 270 gacatccagt tgacccagtc tccatccttc
ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtga
ggacatcgag agctacctgg cttggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagt gcatccactc tgacctctgg cgtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtctcggt gctgacgata ccactaccgt
cttcggcgga 300 gggaccaagg tggaaatcaa a 321 <210> SEQ ID NO
271 <211> LENGTH: 122 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 22H8 VH AA
<400> SEQUENCE: 271 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val
Ser Gly Phe Ser Leu Ser Thr Tyr 20 25 30 Thr Met Asn Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ala Ile Ser
Tyr Asp Gly Gly Thr Ala Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85
90 95 Arg Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp Ala Phe Asp Pro
Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 272 <211> LENGTH: 366 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 22H8
VH nt <400> SEQUENCE: 272 gaggtgcagc tggtggagtc tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggatt
ctccctcagt acctatacaa tgaactgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgggcgcc attagttatg atggtggcac agcctacgcg 180
aactgggcga aaggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg
240 caactcaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtttttat 300 gtttatgctt atattgggga tgctttcgat ccctggggcc
agggcaccct ggtcaccgtc 360 tcgagc 366 <210> SEQ ID NO 273
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 22H8 VL AA <400>
SEQUENCE: 273 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln
Thr Val Tyr Lys Asn 20 25 30 Asn Leu Leu Ser Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Leu Ala Ser Thr
Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 85 90 95 Asp
Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
<210> SEQ ID NO 274 <211> LENGTH: 333 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 22H8
VL nt <400> SEQUENCE: 274 gacatccagt tgacccagtc tccatccttc
ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca
gactgtctat aagaacaacc tcttatcctg gtatcagcaa 120 aaaccaggga
aagcccctaa gctcctgatc tatctggcat ccactctggc atctggcgtc 180
ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg
240 cagcctgaag attttgcaac ttattactgt ctaggcggtt atgatgatga
cgctgatact 300 gctttcggcg gagggaccaa ggtggaaatc aaa 333 <210>
SEQ ID NO 275 <211> LENGTH: 122 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 45G5
VH AA <400> SEQUENCE: 275 Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr
Val Ser Gly Phe Ser Leu Ser Val Tyr 20 25 30 Pro Ile Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile
Asn Asp Val Asp Asp Thr Ala Tyr Ser Ala Trp Ala Lys 50 55 60 Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70
75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
Ala 85 90 95 Arg Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp Ala Phe
Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115
120 <210> SEQ ID NO 276 <211> LENGTH: 366 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 45G5 VH nt <400> SEQUENCE: 276 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag tctctggatt ctccctcagt gtatatccaa taaactgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggcatt attaatgatg ttgatgacac
agcctactca 180 gcctgggcga aaggccgctt caccatcagc cgcgacaact
ccaagaacac cctgtatctg 240 caaatgaaca gcctgcgtgc cgaggacacc
gcggtgtatt actgcgccag aggttatttg 300 agttatgctt atgctggaga
tgctttcgat ccctggggcc agggcaccct ggtcaccgtc 360 tcgagc 366
<210> SEQ ID NO 277 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 45G5
VL AA <400> SEQUENCE: 277 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ser Ser Gln Ser Ile Tyr Asn Asn 20 25 30 Asn Leu Leu Ser Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr
Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70
75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp
Asp 85 90 95 Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys 100 105 110 <210> SEQ ID NO 278 <211> LENGTH:
333 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 45G5 VL nt <400> SEQUENCE: 278 gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc agtccagtca gagtatttat aataacaacc tcttatcctg gtatcagcaa
120 aaaccaggga aagcccctaa gctcctgatc tattttgcat ccactctggc
atctggcgtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca
ctctcacaat cagcagcctg 240 cagcctgaag attttgcaac ttattactgt
ctaggcggtt atgatgatga tgctgatact 300 gctttcggcg gagggaccaa
ggtggaaatc aaa 333 <210> SEQ ID NO 279 <211> LENGTH:
753 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 13A8 LL scfv Ecoli <400> SEQUENCE: 279 gatattcaat
taactcagag cccatctttc ttatctgcca gtgtgggtga tcgtgttact 60
attacatgtc aagcaagcca atcaattagc aacgaattat cttggtacca acagaaacca
120 ggcaaagcac caaagttact catttatcgc gcgtctacct taacttcagg
cgtcccatct 180 cgtttttccg gcagcggctc cggcactgaa tttactttaa
cgatttcctc tttacaaccc 240 gaagattttg cgacttatta ttgccaacag
ggttacaata gcaacgatgt ggataatgta 300 tttggcggcg gcaccaaggt
tgaaattaaa ggaggcggtg gctccggcgg aggcggctca 360 ggcggcggcg
gtagtggagg aggtggttcc gaagttcaac tggtcgaatc aggtggtggt 420
ttagtccaac cgggcggcag tttacgttta tcttgcaccg tgagtggtat cgacttgtct
480 tcttatgatc tctcctgggt acgtcaggca ccgggaaaag gcttggaatg
ggtaggttat 540 atttatacag attcttcaac ttggtatgca aattgggcta
aagggcgctt cactatttcc 600 cgcgataact ctaaaaatac gctctattta
caattaaact cattacgcgc agaagataca 660 gccgtctact attgcgcacg
gggtagcacc gattatgcat ttgatacgcg tctggatctt 720 tggggtcaag
gcaccttagt aaccgtatct tca 753 <210> SEQ ID NO 280 <211>
LENGTH: 251 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 13A8 LL scfv Ecoli <400> SEQUENCE: 280
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn
Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe
Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135
140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser
145 150 155 160 Ser Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys
Gly Leu Glu 165 170 175 Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr
Trp Tyr Ala Asn Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu 195 200 205 Tyr Leu Gln Leu Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Gly Ser
Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu 225 230 235 240 Trp Gly
Gln Gly Thr Leu Val Thr Val Ser Ser 245 250 <210> SEQ ID NO
281 <211> LENGTH: 768 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 28D2 H82L scfv Ecoli
<400> SEQUENCE: 281 gacatccagt tgacccagtc accatcattc
ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc aggccagtga
ggaccttttt agtagtttgg cctggtatca gcaaaaacca 120 ggtaaagccc
ctaagttact gatctattct gcatcaacgc tggcatctgg tgtcccatca 180
cgcttcagcg gcagtggatc tgggacagac ttcactttaa caatcagcag cctgcagccg
240 gaagattttg caacgtatta ctgtttaggt ctttactatt atcttactcc
tgatccgatt 300 tatggtttcg gcggagggac caaggtggaa atcaaaggtg
gcggaggttc tggcggtggt 360 ggcagcggtg ggggtggctc aggaggtggc
ggttccgagg tgcagctggt ggagtctgga 420 ggtggcttgg tacagccggg
cggttcactg cgcctctcct gtacagtctc tggattatca 480 ttaagtaaga
atgcaattgc ctgggtccgt caggcacctg gcaagggttt ggagtgggtg 540
ggcatcattt atgctggtgg tgccacaacc tacgcgagct gggcgaaagg ccgcttcacc
600 atcagccgcg acaactcaaa gaacaccctg tatctgcaat taaacagcct
gcgtgccgag 660 gacaccgcgg tgtattactg cgcccgtgaa tatgctggtg
atagttatta tacgggatac 720 actcagttgg atctctgggg tcagggcacc
ctggtcaccg tctcgagc 768 <210> SEQ ID NO 282 <211>
LENGTH: 256 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 28D2 H82L scfv Ecoli <400> SEQUENCE: 282
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Leu Phe Ser
Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr 85 90 95 Pro Asp Pro Ile Tyr
Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 130 135
140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Ser
145 150 155 160 Leu Ser Lys Asn Ala Ile Ala Trp Val Arg Gln Ala Pro
Gly Lys Gly 165 170 175 Leu Glu Trp Val Gly Ile Ile Tyr Ala Gly Gly
Ala Thr Thr Tyr Ala 180 185 190 Ser Trp Ala Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn 195 200 205 Thr Leu Tyr Leu Gln Leu Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg
Glu Tyr Ala Gly Asp Ser Tyr Tyr Thr Gly Tyr 225 230 235 240 Thr Gln
Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 245 250 255
<210> SEQ ID NO 283 <211> LENGTH: 732 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 31A12 LL scfv
Ecoli <400> SEQUENCE: 283 gacatccagt tgacccagtc accatcattc
ctgtctgcat ctgtaggtga ccgtgtcacc 60 atcacttgcc aggccagtga
ggacattgaa agttatttgg cctggtatca gcaaaaacca 120 ggtaaagccc
ctaagttact gatctattct gcatccacgc tgacctctgg tgtcccatcg 180
cgcttcagcg gcagtggctc tgggacagaa tttactttaa caatcagcag cctgcagccg
240 gaagattttg caacgtatta ctgtttaggt gctgatgaca ctaccacggt
tttcggcggt 300 gggaccaagg tggaaatcaa aggtggcggt ggttctggcg
gtggtggcag cggtggcggt 360 ggctccggcg gtggcggttc cgaggtgcaa
ctggttgagt ctggcggtgg cttggtacag 420 ccgggcggtt ctctgcgtct
ctcctgtaca gcgtctggct tttcactgtc cagctactgg 480 ctgacctggg
ttcgtcaggc acctggcaag ggtttggagt gggtgggcac gattgcgacc 540
agctctactt actacgcgag ctgggcgaaa ggccgcttca ccatcagccg cgacaactcc
600 aagaacaccc tgtatctgca attaaacagc ctgcgtgccg aggacaccgc
agtgtattac 660 tgcgcccgtg gtctgaccac ggattatgat ttggatctct
ggggtcaggg caccctggtt 720 accgtctctt ca 732 <210> SEQ ID NO
284 <211> LENGTH: 244 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 31A12 LL scfv Ecoli
<400> SEQUENCE: 284 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln
Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser
Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr Thr Thr 85
90 95 Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly
Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Glu 115 120 125 Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro Gly Gly Ser 130 135 140 Leu Arg Leu Ser Cys Thr Ala Ser Gly
Phe Ser Leu Ser Ser Tyr Trp 145 150 155 160 Leu Thr Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 165 170 175 Thr Ile Ala Thr
Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 180 185 190 Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Leu 195 200 205
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 210
215 220 Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly Thr Leu
Val 225 230 235 240 Thr Val Ser Ser <210> SEQ ID NO 285
<211> LENGTH: 759 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 22H8 LL scfv Ecoli <400>
SEQUENCE: 285 gacatccagt tgacccagtc accatcattc ctgtctgcat
ctgtaggtga ccgtgtcacc 60 atcacttgcc agtccagtca gactgtttat
aagaataacc tcttgtcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tatttggcat ccacgctggc ctctggtgtc 180 ccatcgcgct
tcagcggcag tggctctggg acagaattta ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggcggtt atgatgacga tgctgatact
300 gctttcggcg gtgggaccaa ggtggaaatc aaaggtggcg gtggttctgg
cggtggtggc 360 agcggtggcg gtggctccgg cggtggcggt tccgaggtgc
aactggttga gtctggcggt 420 ggcttggtac agccgggcgg ttctctgcgt
ctctcctgta cagtctctgg attctccctc 480 agtacctata ctctcaactg
ggttcgtcag gcacctggca agggtttgga gtgggtgggc 540 gctattagtt
atgatggtgg cacagcctac gcaaactggg cgaaaggccg cttcaccatc 600
agccgcgaca actccaagaa caccctgtat ctgcaattaa acagcctgcg tgccgaggac
660 accgcagtgt attactgcgc ccgtggtttc tacgtgtatg cttatatcgg
agatgctttc 720 gatccgtggg gtcagggcac cctggttacc gtctcctct 759
<210> SEQ ID NO 286 <211> LENGTH: 253 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 22H8 LL scfv
Ecoli <400> SEQUENCE: 286 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ser Ser Gln Thr Val Tyr Lys Asn 20 25 30 Asn Leu Leu Ser Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr
Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70
75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp
Asp 85 90 95 Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln 130 135 140 Pro Gly Gly Ser Leu Arg Leu
Ser Cys Thr Val Ser Gly Phe Ser Leu 145 150 155 160 Ser Thr Tyr Thr
Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp
Val Gly Ala Ile Ser Tyr Asp Gly Gly Thr Ala Tyr Ala Asn 180 185 190
Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195
200 205 Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr 210 215 220 Tyr Cys Ala Arg Gly Phe Tyr Val Tyr Ala Tyr Ile Gly
Asp Ala Phe 225 230 235 240 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 245 250 <210> SEQ ID NO 287 <211> LENGTH:
774 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5A LL C H33A bacterial optimized <400>
SEQUENCE: 287 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccagtc cagtcagagt
atttataata acaacctctt atcctggtat 120 cagcaaaaac caggtaaagc
ccctaagtta ctgatctatt ttgcatccac gctggcctct 180 ggtgtcccat
cgcgcttcag cggcagtggc tctgggacag aatttacttt aacaatcagc 240
agcctgcagc cggaagattt tgcaacgtat tactgtttag gcggttatga tgacgatgct
300 gatactgctt tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg
ttctggcggt 360 ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg
aggtgcaact ggttgagtct 420 ggcggtggct tggtacagcc gggcggttct
ctgcgtctct cctgtacagt ctctggattc 480 tccctcagtg tatatgcaat
aaactgggtt cgtcaggcac ctggcaaggg tttggagtgg 540 gtgggcatta
ttaatgatgt tgatgacaca gcctactcag cctgggcgaa aggccgcttc 600
accatcagcc gcgacaactc caagaacacc ctgtatctgc aattaaacag cctgcgtgcc
660 gaggacaccg cagtgtatta ctgcgcccgt ggttatttga gttatgctta
tgctggagat 720 gctttcgatc cgtggggtca gggcaccctg gttaccgtct
cgagcggtat gtga 774 <210> SEQ ID NO 288 <211> LENGTH:
257 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5A LL C H33A bacterial optimized <400>
SEQUENCE: 288 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser
Ser Gln Ser Ile Tyr 20 25 30 Asn Asn Asn Leu Leu Ser Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Phe Ala
Ser Thr Leu Ala Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp
Asp Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105
110 Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu 130 135 140 Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr
Val Ser Gly Phe 145 150 155 160 Ser Leu Ser Val Tyr Ala Ile Asn Trp
Val Arg Gln Ala Pro Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ile
Ile Asn Asp Val Asp Asp Thr Ala Tyr 180 185 190 Ser Ala Trp Ala Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val
Tyr Tyr Cys Ala Arg Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp 225 230
235 240 Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
Gly 245 250 255 Met <210> SEQ ID NO 289 <211> LENGTH:
774 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5\L\C\mp7 bacterial optimized <400> SEQUENCE:
289 atggcggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt
aggtgaccgt 60 gtcaccatca cttgccagtc cagtcagagt atttataata
acaacctctt gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta
ctgatctatt ttgcatccac gctggcctct 180 ggtgtcccat cgcgcttcag
cggcagtggc tctgggacag aatttacttt aacaatcagc 240 agcctgcagc
cggaagattt tgcaacgtat tactgtttag gcggttatga tgacgatgct 300
gatactgctt tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt
360 ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact
ggttgagtct 420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct
cctgtacagt ctctggattc 480 tccctcagtg tatatccaat aaactgggtt
cgtcaggcac ctggcaaggg tttggagtgg 540 gtgggcatta ttaatgatgt
tgatgacaca gcctactcag cctgggcgaa aggccgcttc 600 accatcagcc
gcgacaactc caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660
gaggacaccg cagtgtatta ctgcgcccgt ggttatttga gttatgctta tgctggagat
720 gctttcgatc cgtggggtca gggcaccctg gttaccgtct cgagcggtat gtga 774
<210> SEQ ID NO 290 <211> LENGTH: 257 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 45G5\L\C\mp7
bacterial optimized <400> SEQUENCE: 290 Met Ala Asp Ile Gln
Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp
Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Ile Tyr 20 25 30 Asn
Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40
45 Lys Leu Leu Ile Tyr Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr Ala Phe Gly Gly
Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140 Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145 150 155 160 Ser
Leu Ser Val Tyr Pro Ile Asn Trp Val Arg Gln Ala Pro Gly Lys 165 170
175 Gly Leu Glu Trp Val Gly Ile Ile Asn Asp Val Asp Asp Thr Ala Tyr
180 185 190 Ser Ala Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala
Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg Gly Tyr Leu Ser
Tyr Ala Tyr Ala Gly Asp 225 230 235 240 Ala Phe Asp Pro Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ser Gly 245 250 255 Met <210> SEQ
ID NO 291 <211> LENGTH: 768 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 6 13A8 LL-C scFv No His tag
nucleotide seq <400> SEQUENCE: 291 atggccgata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcggaggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcag gtatgtaa 768 <210> SEQ ID NO 292
<211> LENGTH: 255 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 13A8 LL-C scFv No His tag amino
acid seq <400> SEQUENCE: 292 Met Ala Asp Ile Gln Leu Thr Gln
Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr
Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile
Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65
70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr
Asn Ser 85 90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu
Arg Leu Ser Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser Ser
Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu
Glu Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180 185
190 Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
195 200 205 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe
Asp Thr Arg Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly Met 245 250 255 <210> SEQ ID NO 293
<211> LENGTH: 762 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 13A8 LL-N scFv No His tag
nucleotide seq <400> SEQUENCE: 293 atggaggata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcggaggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcat aa 762 <210> SEQ ID NO 294 <211>
LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 13A8 LL-N scFv No His tag amino acid seq
<400> SEQUENCE: 294 Met Glu Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Arg
Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser 85
90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser
Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser Ser Tyr Asp Leu
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Val
Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180 185 190 Asn Trp
Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205
Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210
215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg
Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser 245 250 <210> SEQ ID NO 295 <211> LENGTH: 747
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 31A12 LL-C scFv no his tag nucleotide seq <400>
SEQUENCE: 295 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccaggc cagtgaggac
attgaaagtt atttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat ccacgctgac ctctggtgtc 180 ccatcgcgct
tcagcggcag tggctctggg acagaattta ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtgctg atgacactac cacggttttc
300 ggcggtggga ccaaggtgga aatcaaaggt ggcggtggtt ctggcggtgg
tggcagcggt 360 ggcggtggct ccggcggtgg cggttccgag gtgcaactgg
ttgagtctgg cggtggcttg 420 gtacagccgg gcggttctct gcgtctctcc
tgtacagcgt ctggcttttc actgtccagc 480 tactggctga cctgggttcg
tcaggcacct ggcaagggtt tggagtgggt gggcacgatt 540 gcgaccagct
ctacttacta cgcgagctgg gcgaaaggcc gcttcaccat cagccgcgac 600
aactccaaga acaccctgta tctgcaatta aacagcctgc gtgccgagga caccgcagtg
660 tattactgcg cccgtggtct gaccacggat tatgatttgg atctctgggg
tcagggcacc 720 ctggttaccg tctcgagcgg tatgtga 747 <210> SEQ ID
NO 296 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 23 31A12 LL-C scFv no his
tag amino acid seq <400> SEQUENCE: 296 Met Ala Asp Ile Gln
Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp
Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40
45 Leu Ile Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe
50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser
Ser Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly
Ala Asp Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg
Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr
Trp Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170
175 Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys
180 185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr Leu 195 200 205 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala 210 215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp
Leu Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly
Met 245 <210> SEQ ID NO 297 <211> LENGTH: 741
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 31A12 LL-N scFv no histag nucleotide seq <400>
SEQUENCE: 297 atggaggaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccaggc cagtgaggac
attgaaagtt atttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat ccacgctgac ctctggtgtc 180 ccatcgcgct
tcagcggcag tggctctggg acagaattta ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtgctg atgacactac cacggttttc
300 ggcggtggga ccaaggtgga aatcaaaggt ggcggtggtt ctggcggtgg
tggcagcggt 360 ggcggtggct ccggcggtgg cggttccgag gtgcaactgg
ttgagtctgg cggtggcttg 420 gtacagccgg gcggttctct gcgtctctcc
tgtacagcgt ctggcttttc actgtccagc 480 tactggctga cctgggttcg
tcaggcacct ggcaagggtt tggagtgggt gggcacgatt 540 gcgaccagct
ctacttacta cgcgagctgg gcgaaaggcc gcttcaccat cagccgcgac 600
aactccaaga acaccctgta tctgcaatta aacagcctgc gtgccgagga caccgcagtg
660 tattactgcg cccgtggtct gaccacggat tatgatttgg atctctgggg
tcagggcacc 720 ctggttaccg tctcttcatg a 741 <210> SEQ ID NO
298 <211> LENGTH: 246 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 23 31A12 LL-N scFv no histag
amino acid seq <400> SEQUENCE: 298 Met Glu Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala
Asp Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu
Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr Trp
Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175
Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 180
185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
Leu 195 200 205 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala 210 215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu
Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser 245
<210> SEQ ID NO 299 <211> LENGTH: 768 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Nterm bact constr ntide seq <400> SEQUENCE: 299
atggaggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccagtc cagtcagact gtttataaga ataacctctt
gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta ctgatctatt
tggcatccac gctggcctct 180 ggtgtcccat cgcgcttcag cggcagtggc
tctgggacag aatttacttt aacaatcagc 240 agcctgcagc cggaagattt
tgcaacgtat tactgtttag gcggttatga tgacgatgct 300 gatactgctt
tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt 360
ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact ggttgagtct
420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct cctgtacagt
ctctggattc 480 tccctcagta cctatactct caactgggtt cgtcaggcac
ctggcaaggg tttggagtgg 540 gtgggcgcta ttagttatga tggtggcaca
gcctacgcaa actgggcgaa aggccgcttc 600 accatcagcc gcgacaactc
caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660 gaggacaccg
cagtgtatta ctgcgcccgt ggtttctacg tgtatgctta tatcggagat 720
gctttcgatc cgtggggtca gggcaccctg gttaccgtct cctcttaa 768
<210> SEQ ID NO 300 <211> LENGTH: 255 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Nterm bact constr aa seq <400> SEQUENCE: 300 Met
Glu Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10
15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Val Tyr
20 25 30 Lys Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Ala Ser
Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala
Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr
Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145
150 155 160 Ser Leu Ser Thr Tyr Thr Leu Asn Trp Val Arg Gln Ala Pro
Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ala Ile Ser Tyr Asp Gly
Gly Thr Ala Tyr 180 185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn
Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg
Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp 225 230 235 240 Ala Phe Asp
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 245 250 255
<210> SEQ ID NO 301 <211> LENGTH: 777 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Cterm bact constr ntide seq <400> SEQUENCE: 301
atggccgaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccagtc cagtcagact gtttataaga ataacctctt
gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta ctgatctatt
tggcatccac gctggcctct 180 ggtgtcccat cgcgcttcag cggcagtggc
tctgggacag aatttacttt aacaatcagc 240 agcctgcagc cggaagattt
tgcaacgtat tactgtttag gcggttatga tgacgatgct 300 gatactgctt
tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt 360
ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact ggttgagtct
420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct cctgtacagt
ctctggattc 480 tccctcagta cctatactct gaactgggtt cgtcaggcac
ctggcaaggg tttggagtgg 540 gtgggcgcta ttagttatga tggtggcaca
gcctacgcaa actgggcgaa aggccgcttc 600 accatcagcc gcgacaactc
caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660 gaggacaccg
cagtgtatta ctgcgcccgt ggtttctacg tgtatgctta tatcggagat 720
gctttcgatc cgtggggtca gggcaccctg gttaccgtct cgagcggtat gtgataa 777
<210> SEQ ID NO 302 <211> LENGTH: 257 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Cterm bact constr aa seq <400> SEQUENCE: 302 Met
Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10
15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Val Tyr
20 25 30 Lys Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Ala Ser
Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala
Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr
Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145
150 155 160 Ser Leu Ser Thr Tyr Thr Leu Asn Trp Val Arg Gln Ala Pro
Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ala Ile Ser Tyr Asp Gly
Gly Thr Ala Tyr 180 185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn
Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg
Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp 225 230 235 240 Ala Phe Asp
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 245 250 255 Met
<210> SEQ ID NO 303 <211> LENGTH: 738 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 31A12
LL-Linker scFv no histag ntide seq <400> SEQUENCE: 303
atggcggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccaggc cagtgaggac attgaaagtt atttggcctg
gtatcagcaa 120 aaaccaggta aagcccctaa gttactgatc tattctgcat
ccacgctgac ctctggtgtc 180 ccatcgcgct tcagcggcag tggctctggg
acagaattta ctttaacaat cagcagcctg 240 cagccggaag attttgcaac
gtattactgt ttaggtgctg atgacactac cacggttttc 300 ggcggtggga
ccaaggtgga aatcaaaggt ggcggtggtt ctggcatggg tggcagcggt 360
ggcggtggct ccggcggtgg cggttccgag gtgcaactgg ttgagtctgg cggtggcttg
420 gtacagccgg gcggttctct gcgtctctcc tgtacagcgt ctggcttttc
actgtccagc 480 tactggctga cctgggttcg tcaggcacct ggcaagggtt
tggagtgggt gggcacgatt 540 gcgaccagct ctacttacta cgcgagctgg
gcgaaaggcc gcttcaccat cagccgcgac 600 aactccaaga acaccctgta
tctgcaatta aacagcctgc gtgccgagga caccgcagtg 660 tattactgcg
cccgtggtct gaccacggat tatgatttgg atctctgggg tcagggcacc 720
ctggttaccg tctcgagc 738 <210> SEQ ID NO 304 <211>
LENGTH: 246 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 23 31A12 LL-Linker scFv no his tag aa seq
<400> SEQUENCE: 304 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser
Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr 85
90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly
Gly 100 105 110 Gly Ser Gly Met Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Thr Ala
Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr Trp Leu Thr Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Gly Thr Ile
Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 180 185 190 Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210
215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly
Thr 225 230 235 240 Leu Val Thr Val Ser Ser 245 <210> SEQ ID
NO 305 <211> LENGTH: 762 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 6 13A8 LL-Linker scFv No His
tag ntide seq <400> SEQUENCE: 305 atggccgata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcatgggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcag gt 762 <210> SEQ ID NO 306 <211>
LENGTH: 254 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 13A8 LL-Linker scFv No His tag aa seq
<400> SEQUENCE: 306 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Arg
Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser 85
90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 Gly Gly Gly Gly Ser Gly Met Gly Gly Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser
Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser Ser Tyr Asp Leu
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Val
Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180 185 190 Asn Trp
Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205
Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210
215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg
Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Gly 245 250 <210> SEQ ID NO 307 <211> LENGTH: 819
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 6 28D2 LL-C-met scFv 6His nucleotide sequence <400>
SEQUENCE: 307 atggcacatc accatcacca tcatccaccg ccacctgcgg
ccgcagacat ccagttgacc 60 cagtcaccat cattcctgtc tgcatctgta
ggagaccgtg tcaccatcac ttgccaggcc 120 agtgaggacc tttttagtag
tttggcctgg tatcagcaaa aaccaggtaa agcccctaag 180 ttactgatct
attctgcatc aacgctggca tctggtgtcc catcacgctt cagcggcagt 240
ggatctggga cagacttcac tttaacaatc agcagcctgc agccggaaga ttttgcaacg
300 tattactgtt taggtcttta ctattatctt actcctgatc cgatttatgg
tttcggcgga 360 gggaccaagg tggaaatcaa aggtggcgga ggttctggcg
gtggtggcag cggtgggggt 420 ggctcaggag gtggcggttc cgaggtgcag
ctggtggagt ctggaggtgg cttggtacag 480 ccgggcggtt cactgcgcct
ctcctgtaca gtctctggat tatcattaag taagaatgca 540 attgcctggg
tccgtcaggc acctggcaag ggtttggagt gggtgggcat catttatgct 600
ggtggtgcca caacctacgc gagctgggcg aaaggccgct tcaccatcag ccgcgacaac
660 tcaaagaaca ccctgtatct gcaattaaac agcctgcgtg ccgaggacac
cgcggtgtat 720 tactgcgccc gtgaatatgc tggtgatagt tattatacgg
gatacactca gttggatctc 780 tggggtcagg gcaccctggt caccgtctcg
agcggtatg 819 <210> SEQ ID NO 308 <211> LENGTH: 273
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 6 28D2 LL-C-met scFv 6His amino acid sequence <400>
SEQUENCE: 308 Met Ala His His His His His His Pro Pro Pro Pro Ala
Ala Ala Asp 1 5 10 15 Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser
Ala Ser Val Gly Asp 20 25 30 Arg Val Thr Ile Thr Cys Gln Ala Ser
Glu Asp Leu Phe Ser Ser Leu 35 40 45 Ala Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 50 55 60 Ser Ala Ser Thr Leu
Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 65 70 75 80 Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 85 90 95 Asp
Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr Pro 100 105
110 Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly 130 135 140 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu Val Gln 145 150 155 160 Pro Gly Gly Ser Leu Arg Leu Ser Cys
Thr Val Ser Gly Leu Ser Leu 165 170 175 Ser Lys Asn Ala Ile Ala Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu 180 185 190 Glu Trp Val Gly Ile
Ile Tyr Ala Gly Gly Ala Thr Thr Tyr Ala Ser 195 200 205 Trp Ala Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 210 215 220 Leu
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 225 230
235 240 Tyr Cys Ala Arg Glu Tyr Ala Gly Asp Ser Tyr Tyr Thr Gly Tyr
Thr 245 250 255 Gln Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val
Ser Ser Gly 260 265 270 Met <210> SEQ ID NO 309 <211>
LENGTH: 810 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 28D2 LL-N-met scFv 6His nucleotide sequence
<400> SEQUENCE: 309 atggaagaca tccagttgac ccagtcacca
tcattcctgt ctgcatctgt aggagaccgt 60 gtcaccatca cttgccaggc
cagtgaggac ctttttagta gtttggcctg gtatcagcaa 120 aaaccaggta
aagcccctaa gttactgatc tattctgcat caacgctggc atctggtgtc 180
ccatcacgct tcagcggcag tggatctggg acagacttca ctttaacaat cagcagcctg
240 cagccggaag attttgcaac gtattactgt ttaggtcttt actattatct
tactcctgat 300 ccgatttatg gtttcggcgg agggaccaag gtggaaatca
aaggtggcgg aggttctggc 360 ggtggtggca gcggtggggg tggctcagga
ggtggcggtt ccgaggtgca gctggtggag 420 tctggaggtg gcttggtaca
gccgggcggt tcactgcgcc tctcctgtac agtctctgga 480 ttatcattaa
gtaagaatgc aattgcctgg gtccgtcagg cacctggcaa gggtttggag 540
tgggtgggca tcatttatgc tggtggtgcc acaacctacg cgagctgggc gaaaggccgc
600 ttcaccatca gccgcgacaa ctcaaagaac accctgtatc tgcaattaaa
cagcctgcgt 660 gccgaggaca ccgcggtgta ttactgcgcc cgtgaatatg
ctggtgatag ttattatacg 720 ggatacactc agttggatct ctggggtcag
ggcaccctgg tcaccgtctc gagcggtcca 780 ccgcctccac cgcaccatca
ccatcatcac 810 <210> SEQ ID NO 310 <211> LENGTH: 270
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 6 28D2 LL-N-met scFv 6His amino acid sequence <400>
SEQUENCE: 310 Met Glu Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala
Ser Glu Asp Leu Phe 20 25 30 Ser Ser Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr
Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr 85 90 95 Leu
Thr Pro Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val Glu 100 105
110 Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly
Gly Gly 130 135 140 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
Thr Val Ser Gly 145 150 155 160 Leu Ser Leu Ser Lys Asn Ala Ile Ala
Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Val Gly
Ile Ile Tyr Ala Gly Gly Ala Thr Thr 180 185 190 Tyr Ala Ser Trp Ala
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 195 200 205 Lys Asn Thr
Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr 210 215 220 Ala
Val Tyr Tyr Cys Ala Arg Glu Tyr Ala Gly Asp Ser Tyr Tyr Thr 225 230
235 240 Gly Tyr Thr Gln Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr
Val 245 250 255 Ser Ser Gly Pro Pro Pro Pro Pro His His His His His
His 260 265 270 <210> SEQ ID NO 311 <211> LENGTH: 810
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 6 28D2 LL-Linker scFv 6His ntide seq <400>
SEQUENCE: 311 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggagaccgt 60 gtcaccatca cttgccaggc cagtgaggac
ctttttagta gtttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat caacgctggc atctggtgtc 180 ccatcacgct
tcagcggcag tggatctggg acagacttca ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtcttt actattatct tactcctgat
300 ccgatttatg gtttcggcgg agggaccaag gtggaaatca aaggtggcgg
aggttctggc 360 atgggtggca gcggtggggg tggctcagga ggtggcggtt
ccgaggtgca gctggtggag 420 tctggaggtg gcttggtaca gccgggcggt
tcactgcgcc tctcctgtac agtctctgga 480 ttatcattaa gtaagaatgc
aattgcctgg gtccgtcagg cacctggcaa gggtttggag 540 tgggtgggca
tcatttatgc tggtggtgcc acaacctacg cgagctgggc gaaaggccgc 600
ttcaccatca gccgcgacaa ctcaaagaac accctgtatc tgcaattaaa cagcctgcgt
660 gccgaggaca ccgcggtgta ttactgcgcc cgtgaatatg ctggtgatag
ttattatacg 720 ggatacactc agttggatct ctggggtcag ggcaccctgg
tcaccgtctc gagcggtcca 780 ccgcctccac cgcaccatca ccatcatcac 810
<210> SEQ ID NO 312 <211> LENGTH: 270 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 6 28D2 LL-Linker
scFv 6His aa seq <400> SEQUENCE: 312 Met Ala Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Leu Phe 20 25 30 Ser Ser
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu
Tyr Tyr Tyr 85 90 95 Leu Thr Pro Asp Pro Ile Tyr Gly Phe Gly Gly
Gly Thr Lys Val Glu 100 105 110 Ile Lys Gly Gly Gly Gly Ser Gly Met
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Glu
Val Gln Leu Val Glu Ser Gly Gly Gly 130 135 140 Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly 145 150 155 160 Leu Ser
Leu Ser Lys Asn Ala Ile Ala Trp Val Arg Gln Ala Pro Gly 165 170 175
Lys Gly Leu Glu Trp Val Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr 180
185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser 195 200 205 Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala
Glu Asp Thr 210 215 220 Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Ala Gly
Asp Ser Tyr Tyr Thr 225 230 235 240 Gly Tyr Thr Gln Leu Asp Leu Trp
Gly Gln Gly Thr Leu Val Thr Val 245 250 255 Ser Ser Gly Pro Pro Pro
Pro Pro His His His His His His 260 265 270 <210> SEQ ID NO
313 <211> LENGTH: 837 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 313
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc
60 tatgatatga cccagactcc agcctctgtg gaggtagcta tgggaggcac
agtcaccatc 120 aagtgccagg ccagtcagag cattagcaat gaattatcct
ggtatcagca gaaaccaggg 180 cagcctccca agctcctgat ctacaggaca
tccactctgg catctggggt ctcatcgcgg 240 ttcaaaggca gtggatctgg
gacagagtac actctcacca tcagcggcgt ggagtgtgcc 300 gatgctgcca
cttactactg tcaacagggt tataatagta atgatgttga taatgttttc 360
ggcggaggga ccaaggtggt ggtcgtcggc ggtggcggtt ctggtggtgg cggtagcggc
420 ggcggtggtt ccggaggagg cggatcccag tcggtggagg agtccggggg
tcgcctggtc 480 acgcctggga cacccctgac actcacctgc acagtctctg
gaatcgacct cagtagctac 540 gacatgagct gggtccgcca ggctccaggg
aaggggctgg agtggatcgg atacatttat 600 actgatagta gcacatacta
cgcgaactgg gcgaaaggcc gattcaccat ctccaaaacc 660 tcgaccacgg
tggatctgaa aatgaccagt ctgacaaccg aggacacggc cacctatttc 720
tgtgccaaag gtagtaccga ttatgctttc gacactcggt tggatctctg gggcccaggc
780 accctggtca ccgtctcgag tggtccacct cctccacctc accatcacca tcatcac
837 <210> SEQ ID NO 314 <211> LENGTH: 279 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 314 Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu
Leu Leu Trp 1 5 10 15 Leu Pro Gly Ala Tyr Asp Met Thr Gln Thr Pro
Ala Ser Val Glu Val 20 25 30 Ala Met Gly Gly Thr Val Thr Ile Lys
Cys Gln Ala Ser Gln Ser Ile 35 40 45 Ser Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys 50 55 60 Leu Leu Ile Tyr Arg
Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg 65 70 75 80 Phe Lys Gly
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly 85 90 95 Val
Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn 100 105
110 Ser Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Val Val
115 120 125 Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 130 135 140 Gly Gly Gly Gly Ser Gln Ser Val Glu Glu Ser Gly
Gly Arg Leu Val 145 150 155 160 Thr Pro Gly Thr Pro Leu Thr Leu Thr
Cys Thr Val Ser Gly Ile Asp 165 170 175 Leu Ser Ser Tyr Asp Met Ser
Trp Val Arg Gln Ala Pro Gly Lys Gly 180 185 190 Leu Glu Trp Ile Gly
Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala 195 200 205 Asn Trp Ala
Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val 210 215 220 Asp
Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe 225 230
235 240 Cys Ala Lys Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu 245 250 255 Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Pro
Pro Pro Pro 260 265 270 Pro His His His His His His 275 <210>
SEQ ID NO 315 <211> LENGTH: 789 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 9C8v6-LL scFV
nuc <400> SEQUENCE: 315 gacatccagc tcacccagtc tccatcctct
gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagg acatccactc tggcatctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggaaatcaaa ggcggtggcg
gttctggtgg tggcggtagc 360 ggcggcggtg gttccggagg gggcggatcc
gaggtgcagc tggtggagtc tggcggtggc 420 ttggtacagc cgggcgggtc
cctgcgcctc tcctgtacag tctctggaat cgacctcagt 480 agctacgacc
tcagctgggt ccgtcaggca cctggcaagg gtttggagtg ggtgggctac 540
atttatactg atagtagcac atactacgcg aactgggcga agggccgctt caccatcagc
600 cgcgacaact ccaagaacac cctgtatctg caactcaaca gcctgcgtgc
cgaggacacc 660 gcggtgtatt actgcgccag aggtagtacc gattatgctt
tcgacactcg gttggatctc 720 tggggccagg gcaccctggt caccgtctcg
agcggtccac ctcctccacc tcaccatcac 780 catcatcac 789 <210> SEQ
ID NO 316 <211> LENGTH: 263 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8v6-LL scFV AA <400>
SEQUENCE: 316 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val
Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 100 105
110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly
Ile Asp Leu Ser 145 150 155 160 Ser Tyr Asp Leu Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Gly Tyr Ile Tyr Thr
Asp Ser Ser Thr Tyr Tyr Ala Asn Trp 180 185 190 Ala Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 195 200 205 Tyr Leu Gln
Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys
Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu 225 230
235 240 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Pro Pro Pro
Pro 245 250 255 Pro His His His His His His 260 <210> SEQ ID
NO 317 <211> LENGTH: 263 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8v3-1 scFV AA <400>
SEQUENCE: 317 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val
Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 100 105
110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly
Ile Asp Leu Ser 145 150 155 160 Ser Tyr Asp Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Gly Tyr Ile Tyr Thr
Asp Ser Ser Thr Tyr Tyr Ala Asn Trp 180 185 190 Ala Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 195 200 205 Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys
Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu 225 230
235 240 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Pro Pro Pro
Pro 245 250 255 Pro His His His His His His 260 <210> SEQ ID
NO 318 <211> LENGTH: 789 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8v3-1 scFV nuc <400>
SEQUENCE: 318 gacatccaga tgacccagtc tccatcctct gtgtctgcat
ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcattagc
aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct
gatctatagg acatccactc tggcatctgg ggtcccatca 180 aggttcagcg
gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt tgataatgtt
300 ttcggcggag ggaccaaggt ggaaatcaaa ggcggtggcg gttctggtgg
tggcggtagc 360 ggcggcggtg gttccggagg gggcggatcc gaggtgcagc
tggtggagtc tggcggtggc 420 ttggtacagc cgggcgggtc cctgcgcctc
tcctgtacag tctctggaat cgacctcagt 480 agctacgaca tgagctgggt
ccgtcaggca cctggcaagg gtttggagtg ggtgggctac 540 atttatactg
atagtagcac atactacgcg aactgggcga agggccgctt caccatcagc 600
cgcgacaact ccaagaacac cctgtatctg caaatgaaca gcctgcgtgc cgaggacacc
660 gcggtgtatt actgcgccag aggtagtacc gattatgctt tcgacactcg
gttggatctc 720 tggggccagg gcaccctggt caccgtctcg agcggtccac
ctcctccacc tcaccatcac 780 catcatcac 789 <210> SEQ ID NO 319
<211> LENGTH: 789 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 9C8v3-2 scFV nuc <400>
SEQUENCE: 319 gacatccaga tgacccagtc tccatcctct gtgtctgcat
ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcattagc
aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct
gatctatagg acatccactc tggcatctgg ggtcccatca 180 aggttcagcg
gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt tgataatgtt
300 ttcggcggag ggaccaaggt ggaaatcaaa ggcggtggcg gttctggtgg
tggcggtagc 360 ggcggcggtg gttccggagg gggcggatcc gaggtgcagc
tggtggagtc tggcggtggc 420 ttggtacagc cgggcgggtc cctgcgcctc
tcctgtgcag cttctggaat cgacctcagt 480 agctacgaca tgagctgggt
ccgtcaggca cctggcaagg gtttggagtg ggtgggctac 540 atttatactg
atagtagcac atactacgcg aactgggcga agggccgctt caccatcagc 600
cgcgacaact ccaagaacac cctgtatctg caaatgaaca gcctgcgtgc cgaggacacc
660 gcggtgtatt actgcgccag aggtagtacc gattatgctt tcgacactcg
gttggatctc 720 tggggccagg gcaccctggt caccgtctcg agcggtccac
ctcctccacc tcaccatcac 780 catcatcac 789 <210> SEQ ID NO 320
<211> LENGTH: 263 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 9C8v3-2 scFV AA <400>
SEQUENCE: 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val
Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 100 105
110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Ile Asp Leu Ser 145 150 155 160 Ser Tyr Asp Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Gly Tyr Ile Tyr Thr
Asp Ser Ser Thr Tyr Tyr Ala Asn Trp 180 185 190 Ala Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 195 200 205 Tyr Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys
Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu 225 230
235 240 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Pro Pro Pro
Pro 245 250 255 Pro His His His His His His 260 <210> SEQ ID
NO 321 <211> LENGTH: 330 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8-vK-humAb 1&2 nuc
<400> SEQUENCE: 321 gacatccagt tgacccagtc tccatccttc
ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagg acatccactc tggcatctgg agtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggaaatcaaa 330 <210> SEQ
ID NO 322 <211> LENGTH: 110 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8-vK-huMab 1&2 AA
<400> SEQUENCE: 322 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln
Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser
Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85
90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100
105 110 <210> SEQ ID NO 323 <211> LENGTH: 363
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8-vH humAbv1- nuc <400> SEQUENCE: 323 gaggtgcagc
tggtggagac tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtgcag cttctggaat cgacctcagt agctacgaca tgagctgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgagctac atttatactg atagtagcac
atactacgcg 180 aactgggcga agggccgctt caccatcagc cgcgacaatt
ccaagaacac cctgtatctg 240 caaatgaaca gcctgcgtgc cgaggacacc
gcggtgtatt actgcgccag aggtagtacc 300 gattatgctt tcgacactcg
gttggatctc tggggccagg gcaccctggt caccgtctcg 360 agt 363 <210>
SEQ ID NO 324 <211> LENGTH: 121 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 9C8-vH humAbv1
AA <400> SEQUENCE: 324 Glu Val Gln Leu Val Glu Thr Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Ile Asp Leu Ser Ser Tyr 20 25 30 Asp Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile
Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70
75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
Ala 85 90 95 Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 325 <211> LENGTH: 363 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 9C8-vH humAbv2
nuc <400> SEQUENCE: 325 gaggtgcagc tggtggagac tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtactg tctctggaat
cgacctcagt agctacgaca tgagctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgagctac atttatactg atagtagcac atactacgcg 180
aactgggcga agggccgctt caccatcagc cgcgacaatt ccaagaacac cctgtatctg
240 caaatgaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtagtacc 300 gattatgctt tcgacactcg gttggatctc tggggccagg
gcaccctggt caccgtctcg 360 agt 363 <210> SEQ ID NO 326
<211> LENGTH: 121 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 9C8-vH humAbv2 AA <400>
SEQUENCE: 326 Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile
Asp Leu Ser Ser Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Tyr Thr Asp Ser
Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg
Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly 100 105
110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID
NO 327 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Linker, 4 repeats
<400> SEQUENCE: 327 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20 <210>
SEQ ID NO 328 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Linker, 3
repeats <400> SEQUENCE: 328 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 329
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Linker, 5 repeats <400>
SEQUENCE: 329 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25
<210> SEQ ID NO 330 <211> LENGTH: 18 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Linker, non
integer repeat <400> SEQUENCE: 330 Gly Gly Gly Gly Ser Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1 5 10 15 Gly Ser
<210> SEQ ID NO 331 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 31A12 F12S
mutation <400> SEQUENCE: 331 Met Ala Asp Ile Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr
Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile
Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65
70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp
Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser
Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr Trp Leu
Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val
Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 180 185
190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
195 200 205 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys Ala 210 215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp
Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Met 245
<210> SEQ ID NO 332 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 31A12 pI
optimization <400> SEQUENCE: 332 Met Ala Asp Ile Gln Leu Thr
Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu
Ile Tyr Ser Ala Ser Thr Arg Thr Ser Gly Val Pro Ser Arg Phe 50 55
60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu
65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp
Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys Arg Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Lys Pro 130 135 140 Gly Gly Ser Leu Arg Leu
Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 145 150 155 160 Ser Tyr Trp
Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp
Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala 180 185
190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
195 200 205 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 210 215 220 Ala Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu
Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Ser Gly Met
245 <210> SEQ ID NO 333 <211> LENGTH: 249 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: 31A12
combnd pI optimiz and F12S mut <400> SEQUENCE: 333 Met Ala
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 1 5 10 15
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Glu 20
25 30 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Arg Thr Ser Gly Val Pro
Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu
Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
Cys Leu Gly Ala Asp Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly
Thr Lys Val Glu Ile Lys Arg Gly Gly 100 105 110 Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 130 135 140 Gly
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 145 150
155 160 Ser Tyr Trp Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu 165 170 175 Trp Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala
Ser Trp Ala 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 195 200 205 Leu Gln Leu Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Gly Leu Thr Thr Asp
Tyr Asp Leu Asp Leu Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr
Val Ser Ser Gly Met 245 <210> SEQ ID NO 334 <211>
LENGTH: 256 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 13A18 pI optimization <400> SEQUENCE: 334
Met Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5
10 15 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
Ser 20 25 30 Asn Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala
Pro Lys Leu 35 40 45 Leu Ile Tyr Arg Ala Ser Thr Arg Thr Ser Gly
Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe
Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr
Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser 85 90 95 Asn Asp Val Asp Asn
Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135
140 Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile
145 150 155 160 Asp Leu Ser Ser Tyr Asp Leu Ser Trp Val Arg Gln Ala
Pro Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Tyr Ile Tyr Thr Asp
Ser Ser Thr Trp Tyr 180 185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu
Asn Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala
Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg 225 230 235 240 Leu Asp
Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Met 245 250 255
<210> SEQ ID NO 335 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR2 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (6)..(6) <223> OTHER INFORMATION: Xaa selected from
gly, asp, gln, cys, ser, thr and tyr <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (9)..(9)
<223> OTHER INFORMATION: Xaa selected from phe, trp and tyr
<400> SEQUENCE: 335 Tyr Ile Tyr Thr Asp Xaa Ser Thr Xaa Tyr
Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 336
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: CDR5 region <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is alanine or threonine.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (6)..(6) <223> OTHER INFORMATION: Xaa is alanine or
threonine. <400> SEQUENCE: 336 Arg Xaa Ser Thr Leu Xaa Ser 1
5 <210> SEQ ID NO 337 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR2 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa selected from
ser, pro and asp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (7)..(7) <223> OTHER INFORMATION: Xaa
selected from lys and gln <400> SEQUENCE: 337 Tyr Tyr Ala Xaa
Trp Ala Xaa Gly 1 5 <210> SEQ ID NO 338 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: CDR5 region <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is selected from the group consisting of serine
and alanine <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
selected from ala and thr <400> SEQUENCE: 338 Ala Xaa Thr Leu
Xaa Ser 1 5 <210> SEQ ID NO 339 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: CDR3 region <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (4)..(4) <223> OTHER
INFORMATION: Xaa is alanine or isoleucine <400> SEQUENCE: 339
Tyr Ala Tyr Xaa Gly Asp Ala Phe Asp Pro 1 5 10 <210> SEQ ID
NO 340 <211> LENGTH: 6 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: CDR3 region <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(6)..(6) <223> OTHER INFORMATION: Xaa is isoleucine or valine
<400> SEQUENCE: 340 Ser Asp Tyr Phe Asn Xaa 1 5 <210>
SEQ ID NO 341 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR5 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa is lysine or
threonine <400> SEQUENCE: 341 Ala Ser Xaa Leu Ala 1 5
<210> SEQ ID NO 342 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR6 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (6)..(6) <223> OTHER INFORMATION: Xaa is is alanine
or valine <400> SEQUENCE: 342 Gln Ser Tyr Tyr Asp Xaa Asn Ala
Gly Tyr Gly 1 5 10 <210> SEQ ID NO 343 <211> LENGTH:
679 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 343 gtacaaaaaa gcaggctcca
ccatgaactc cttctccaca agcgccttcg gtccagttgc 60 cttctccctg
gggctgctcc tggtgttgcc tgctgccttc cctgccccag tacccccagg 120
agaagattcc aaagatgtag ccgccccaca cagacagcca ctcacctctt cagaacgaat
180 tgacaaacaa attcggtaca tcctcgacgg catctcagcc ctgagaaagg
agacatgtaa 240 caagagtaac atgtgtgaaa gcagcaaaga ggcactggca
gaaaacaacc tgaaccttcc 300 aaagatggct gaaaaagatg gatgcttcca
atctggattc aatgaggaga cttgcctggt 360 gaaaatcatc actggtcttt
tggagtttga ggtataccta gagtacctcc agaacagatt 420 tgagagtagt
gaggaacaag ccagagctgt gcagatgagt acaaaagtcc tgatccagtt 480
cctgcagaaa aaggcaaaga atctagatgc aataaccacc cctgacccaa ccacaaatgc
540 cagcctgctg acgaagctgc aggcacagaa ccagtggctg caggacatga
caactcatct 600 cattctgcgc agctttaagg agttcctgca gtccagcctg
agggctcttc ggcaaatgta 660 ggacccagct ttcttgtac 679 <210> SEQ
ID NO 344 <211> LENGTH: 212 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct <400> SEQUENCE: 344
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 1 5
10 15 Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro
Pro 20 25 30 Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln
Pro Leu Thr 35 40 45 Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr
Ile Leu Asp Gly Ile 50 55 60 Ser Ala Leu Arg Lys Glu Thr Cys Asn
Lys Ser Asn Met Cys Glu Ser 65 70 75 80 Ser Lys Glu Ala Leu Ala Glu
Asn Asn Leu Asn Leu Pro Lys Met Ala 85 90 95 Glu Lys Asp Gly Cys
Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 100 105 110 Val Lys Ile
Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 115 120 125 Leu
Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 130 135
140 Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn
145 150 155 160 Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala
Ser Leu Leu 165 170 175 Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln
Asp Met Thr Thr His 180 185 190 Leu Ile Leu Arg Ser Phe Lys Glu Phe
Leu Gln Ser Ser Leu Arg Ala 195 200 205 Leu Arg Gln Met 210
<210> SEQ ID NO 345 <211> LENGTH: 18 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Amino terminal
triple FLAG tag <400> SEQUENCE: 345 Asp His Asp Gly Asp Tyr
Lys Asp His Asp Ile Asp Tyr Lys Asp Asp 1 5 10 15 Asp Asp
<210> SEQ ID NO 346 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence:
Carboxyl-terminal Avi tag <400> SEQUENCE: 346 Gly Leu Asn Asp
Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 1 5 10 15 <210>
SEQ ID NO 347 <211> LENGTH: 639 <212> TYPE: DNA
<213> ORGANISM: Macaca mulatta <400> SEQUENCE: 347
atgaactcct tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg
60 gtgttgcctg ctgccttccc cgccccagta ctcccaggag aagattccaa
aaatgtagcc 120 gccccacaca gccagccact gacctcttca gaacgaattg
acaaacacat tcggtacatc 180 ctcgacggca tctcagccct gagaaaggag
acatgtaaca ggagtaacat gtgtgaaagc 240 agcaaagagg cactggcaga
aaacaacctg aaccttccaa agatggctga aaaagatgga 300 tgcttccaat
ctggattcaa tgaggacact tgcctggtga aaatcatcac tggtcttttg 360
gagtttgagg tatacctaga gtacctccag aacaggtttg agagtagtga ggagcaagcc
420 agagctgtgc aaatgagtac aaaagtcctg atccagttcc tgcagaaaaa
ggcaaagaat 480 ctagatgcaa taaccacccc tgaaccaacc acaaatgcca
gcctgctgac gaagctgcag 540 gcacagaacc agtggctgca ggacatgacg
acgcatctca tcctgcgcag ctttaaggag 600 ttcctgcagt ccaacctgag
ggctcttcgg caaatgtag 639 <210> SEQ ID NO 348 <211>
LENGTH: 212 <212> TYPE: PRT <213> ORGANISM: Macaca
mulatta <400> SEQUENCE: 348 Met Asn Ser Phe Ser Thr Ser Ala
Phe Gly Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu Leu Leu Val Leu
Pro Ala Ala Phe Pro Ala Pro Val Leu Pro 20 25 30 Gly Glu Asp Ser
Lys Asn Val Ala Ala Pro His Ser Gln Pro Leu Thr 35 40 45 Ser Ser
Glu Arg Ile Asp Lys His Ile Arg Tyr Ile Leu Asp Gly Ile 50 55 60
Ser Ala Leu Arg Lys Glu Thr Cys Asn Arg Ser Asn Met Cys Glu Ser 65
70 75 80 Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys
Met Ala 85 90 95 Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu
Asp Thr Cys Leu 100 105 110 Val Lys Ile Ile Thr Gly Leu Leu Glu Phe
Glu Val Tyr Leu Glu Tyr 115 120 125 Leu Gln Asn Arg Phe Glu Ser Ser
Glu Glu Gln Ala Arg Ala Val Gln 130 135 140 Met Ser Thr Lys Val Leu
Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 145 150 155 160 Leu Asp Ala
Ile Thr Thr Pro Glu Pro Thr Thr Asn Ala Ser Leu Leu 165 170 175 Thr
Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 180 185
190 Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Asn Leu Arg Ala
195 200 205 Leu Arg Gln Met 210 <210> SEQ ID NO 349
<211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Amino terminal signal sequence
<400> SEQUENCE: 349 Met Asn Ser Phe Ser Thr Ser Ala Phe Gly
Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu Leu Leu Val Leu Pro Ala
Ala Phe Pro Ala Pro 20 25 <210> SEQ ID NO 350 <211>
LENGTH: 3423 <212> TYPE: DNA <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 350 ctccctcttt ccctcacagc cgacgaggca
acaattaggc tttggggata aaacgaggtg 60 cggagagcgg gctggggcat
ttctccccga gatggcgggt ctgacggcgg cggccccgcg 120 gcccggagtc
ctcctgctcc tgctgtccat cctccacccc tctcggcctg gaggggtccc 180
tggggccatt cctggtggag ttcctggagg agtcttttat ccaggggctg gtctcggagc
240 ccttggagga ggagcgctgg ggcctggagg caaacctctt aagccagttc
ccggagggct 300 tgcgggtgct ggccttgggg cagggctcgg cgccttcccc
gcagttacct ttccgggggc 360 tctggtgcct ggtggagtgg ctgacgctgc
tgcagcctat aaagctgcta aggctggcgc 420 tgggcttggt ggtgtcccag
gagttggtgg cttaggagtg tctgcaggtg cggtggttcc 480 tcagcctgga
gccggagtga agcctgggaa agtgccgggt gtggggctgc caggtgtata 540
cccaggtggc gtgctcccag gagctcggtt ccccggtgtg ggggtgctcc ctggagttcc
600 cactggagca ggagttaagc ccaaggctcc aggtgtaggt ggagcttttg
ctggaatccc 660 aggagttgga ccctttgggg gaccgcaacc tggagtccca
ctggggtatc ccatcaaggc 720 ccccaagctg cctggtggct atggactgcc
ctacaccaca gggaaactgc cctatggcta 780 tgggcccgga ggagtggctg
gtgcagcggg caaggctggt tacccaacag ggacaggggt 840 tggcccccag
gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc 900
agccggagtc ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc
960 tggaattgga ggcatcgcag gcgttgggac tccagctgca gctgcagctg
cagcagcagc 1020 cgctaaggca gccaagtatg gagctgctgc aggcttagtg
cctggtgggc caggctttgg 1080 cccgggagta gttggtgtcc caggagctgg
cgttccaggt gttggtgtcc caggagctgg 1140 gattccagtt gtcccaggtg
ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc 1200 agaagcagct
gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg 1260
agttggaggc attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg
1320 agtcggaggt atccctggag tcgcaggtgt ccctggtgtc ggaggtgttc
ccggagtcgg 1380 aggtgtcccg ggagttggca tttcccccga agctcaggca
gcagctgccg ccaaggctgc 1440 caagtacggg ttagttcctg gtgtcggcgt
ggctcctgga gttggcgtgg ctcctggtgt 1500 cggtgtggct cctggagttg
gcttggctcc tggagttggc gtggctcctg gagttggtgt 1560 ggctcctggc
gttggcgtgg ctcccggcat tggccctggt ggagttgcag ctgcagcaaa 1620
atccgctgcc aaggtggctg ccaaagccca gctccgagct gcagctgggc ttggtgctgg
1680 catccctgga cttggagttg gtgtcggcgt ccctggactt ggagttggtg
ctggtgttcc 1740 tggacttgga gttggtgctg gtgttcctgg cttcggggca
gtacctggag ccctggctgc 1800 cgctaaagca gccaaatatg gagcagcagt
gcctggggtc cttggagggc tcggggctct 1860 cggtggagta ggcatcccag
gcggtgtggt gggagccgga cccgccgccg ccgctgccgc 1920 agccaaagct
gctgccaaag ccgcccagtt tggcctagtg ggagccgctg ggctcggagg 1980
actcggagtc ggagggcttg gagttccagg tgttgggggc cttggaggta tacctccagc
2040 tgcagccgct aaagcagcta aatacggtgc tgctggcctt ggaggtgtcc
tagggggtgc 2100 cgggcagttc ccacttggag gagtggcagc aagacctggc
ttcggattgt ctcccatttt 2160 cccaggtggg gcctgcctgg ggaaagcttg
tggccggaag agaaaatgag cttcctagga 2220 cccctgactc acgacctcat
caacgttggt gctactgctt ggtggagaat gtaaaccctt 2280 tgtaacccca
tcccatgccc ctccgactcc ccaccccagg agggaacggg caggccgggc 2340
ggccttgcag atccacaggg caaggaaaca agaggggagc ggccaagtgc cccgaccagg
2400 aggcccccta cttcagaggc aagggccatg tggtcctggc cccccacccc
atcccttccc 2460 acctaggagc tccccctcca cacagcctcc atctccaggg
gaacttggtg ctacacgctg 2520 gtgctcttat cttcctgggg ggagggagga
gggaagggtg gcccctcggg gaacccccta 2580 cctggggctc ctctaaagat
ggtgcagaca cttcctgggc agtcccagct ccccctgccc 2640 accaggaccc
accgttggct gccatccagt tggtacccaa gcacctgaag cctcaaagct 2700
ggattcgctc tagcatccct cctctcctgg gtccacttgg ccgtctcctc cccaccgatc
2760 gctgttcccc acatctgggg cgcttttggg ttggaaaacc accccacact
gggaatagcc 2820 accttgccct tgtagaatcc atccgcccat ccgtccattc
atccatcggt ccgtccatcc 2880 atgtccccag ttgaccgccc ggcaccacta
gctggctggg tgcacccacc atcaacctgg 2940 ttgacctgtc atggccgcct
gtgccctgcc tccaccccca tcctacactc ccccagggcg 3000 tgcggggctg
tgcagactgg ggtgccaggc atctcctccc cacccggggt gtccccacat 3060
gcagtactgt atacccccca tccctccctc ggtccactga acttcagagc agttcccatt
3120 cctgccccgc ccatcttttt gtgtctcgct gtgatagatc aataaatatt
ttattttttg 3180 tcctggatat ttggggatta tttttgattg ttgatattct
cttttggttt tattgttgtg 3240 gttcattgaa aaaaaaagat aatttttttt
tctgatccgg ggagctgtat ccccagtaga 3300 aaaaacattt taatcactct
aatataactc tggatgaaac acaccttttt ttttaataag 3360 aaaagagaat
taactgcttc agaaatgact aataaatgaa aaacctttaa aggaaaaaaa 3420 aaa
3423 <210> SEQ ID NO 351 <211> LENGTH: 30 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Elastin
linker <400> SEQUENCE: 351 gttcctggag taggggtacc tggggtgggc
30 <210> SEQ ID NO 352 <211> LENGTH: 10 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Sequence encoded by SEQ ID NO: 351 <400> SEQUENCE: 352 Val
Pro Gly Val Gly Val Pro Gly Val Gly 1 5 10 <210> SEQ ID NO
353 <211> LENGTH: 328 <212> TYPE: PRT <213>
ORGANISM: Macaca mulatta <400> SEQUENCE: 353 Met Cys His Gln
Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 1 5 10 15 Ala Ser
Pro Leu Met Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 20 25 30
Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 35
40 45 Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp
Gln 50 55 60 Ser Gly Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile
Gln Val Lys 65 70 75 80 Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His
Lys Gly Gly Glu Ala 85 90 95 Leu Ser His Ser Leu Leu Leu Leu His
Lys Lys Glu Asp Gly Ile Trp 100 105 110 Ser Thr Asp Val Leu Lys Asp
Gln Lys Glu Pro Lys Asn Lys Thr Phe 115 120 125 Leu Arg Cys Glu Ala
Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 130 135 140 Leu Thr Thr
Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 145 150 155 160
Gly Ser Ser Asn Pro Gln Gly Val Thr Cys Gly Ala Val Thr Leu Ser 165
170 175 Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val
Glu 180 185 190 Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Arg
Leu Pro Ile 195 200 205 Glu Val Met Val Asp Ala Ile His Lys Leu Lys
Tyr Glu Asn Tyr Thr 210 215 220 Ser Ser Phe Phe Ile Arg Asp Ile Ile
Lys Pro Asp Pro Pro Lys Asn 225 230 235 240 Leu Gln Leu Lys Pro Leu
Lys Asn Ser Arg Gln Val Glu Val Ser Trp 245 250 255 Glu Tyr Pro Asp
Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 260 265 270 Phe Cys
Ile Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 275 280 285
Ile Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 290
295 300 Ser Phe Ser Val Gln Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp
Ser 305 310 315 320 Glu Trp Ala Ser Val Pro Cys Ser 325 <210>
SEQ ID NO 354 <211> LENGTH: 1080 <212> TYPE: DNA
<213> ORGANISM: Macaca mulatta <400> SEQUENCE: 354
gcccagagca agatgtgtca ccagcagctg gtcatctctt ggttttccct ggtttttctg
60 gcatctcccc tcatggccat atgggaactg aagaaagacg tttatgttgt
agaattggac 120 tggtacccgg atgcccctgg agaaatggtg gtcctcacct
gtgacacccc tgaagaagat 180 ggtatcacct ggaccttgga ccagagtggt
gaggtcttag gctctggcaa aaccctgacc 240 atccaagtca aagagtttgg
agatgctggc cagtacacct gtcacaaagg aggcgaggct 300 ctaagccatt
cactcctgct gcttcacaaa aaggaagatg gaatttggtc cactgatgtt 360
ttaaaggacc agaaagaacc caaaaataag acctttctaa gatgtgaggc caaaaattat
420 tctggacgtt tcacctgctg gtggctgacg acaatcagta ctgatctgac
attcagtgtc 480 aaaagcagca gaggctcttc taacccccaa ggggtgacgt
gtggagccgt tacactctct 540 gcagagaggg tcagagggga caataaggag
tatgagtact cagtggagtg ccaggaggac 600 agtgcctgcc cagccgctga
ggagaggctg cccattgagg tcatggtgga tgccattcac 660 aagctcaagt
atgaaaacta caccagcagc ttcttcatca gggacatcat caaacccgac 720
ccacccaaga acttgcagct gaagccatta aagaattctc ggcaggtgga ggtcagctgg
780 gagtaccctg acacctggag tactccacat tcctacttct ccctgacatt
ctgcatccag 840 gtccagggca agagcaagag agaaaagaaa gatagaatct
tcacagacaa gacctcagcc 900 acggtcatct gccgcaaaaa tgccagcttt
agcgtgcagg cccaggaccg ctactatagc 960 tcatcttgga gcgaatgggc
atctgtgccc tgcagttagg ttgtgatccc aggatgaaaa 1020 attggaggaa
aagtagaaga tattaaccaa aacgtttaaa gacacaacgg aatagaccca 1080
<210> SEQ ID NO 355 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Framework VH
back mutations (H23-30) <400> SEQUENCE: 355 Ala Ala Ser Gly
Ile Asp Leu Ser 1 5 <210> SEQ ID NO 356 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 356 Thr Val Ser Gly Ile Asp Leu Ser 1 5
<210> SEQ ID NO 357 <211> LENGTH: 287 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 357
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc
60 atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca
gcaaaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccactt
tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa
ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta
ctgtcaacag cttaatagtt accctcc 287 <210> SEQ ID NO 358
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: CDR2 region <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa selected from ala, val, leu,
ile, pro, phe, met and trp <400> SEQUENCE: 358 Trp Xaa Lys
Gly 1 <210> SEQ ID NO 359 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: CDR4
region <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is selected from the group consisting of alanine and serine
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa selected from
gly, asn, gln, cys, ser, thr and tyr <400> SEQUENCE: 359 Gln
Xaa Ser Gln Xaa 1 5
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 359
<210> SEQ ID NO 1 <211> LENGTH: 238 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: H.Sapiens 3X
FLAG IL-6 Avi <400> SEQUENCE: 1 Met Ser Ala Leu Leu Ile Leu
Ala Leu Val Gly Ala Ala Val Ala Asp 1 5 10 15 Tyr Lys Asp His Asp
Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys 20 25 30 Asp Asp Asp
Asp Lys Leu Val Pro Pro Gly Glu Asp Ser Lys Asp Val 35 40 45 Ala
Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 50 55
60 Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr
65 70 75 80 Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu
Ala Glu 85 90 95 Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp
Gly Cys Phe Gln 100 105 110 Ser Gly Phe Asn Glu Glu Thr Cys Leu Val
Lys Ile Ile Thr Gly Leu 115 120 125 Leu Glu Phe Glu Val Tyr Leu Glu
Tyr Leu Gln Asn Arg Phe Glu Ser 130 135 140 Ser Glu Glu Gln Ala Arg
Ala Val Gln Met Ser Thr Lys Val Leu Ile 145 150 155 160 Gln Phe Leu
Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro 165 170 175 Asp
Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 180 185
190 Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys
195 200 205 Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met Ala
Ser Gly 210 215 220 Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp
His Glu 225 230 235 <210> SEQ ID NO 2 <211> LENGTH: 244
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: H.Sapiens 3X FLAG IL-6 Myc <400> SEQUENCE: 2 Met
Ser Ala Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala Asp 1 5 10
15 Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys
20 25 30 Asp Asp Asp Asp Lys Leu Val Pro Pro Gly Glu Asp Ser Lys
Asp Val 35 40 45 Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu
Arg Ile Asp Lys 50 55 60 Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser
Ala Leu Arg Lys Glu Thr 65 70 75 80 Cys Asn Lys Ser Asn Met Cys Glu
Ser Ser Lys Glu Ala Leu Ala Glu 85 90 95 Asn Asn Leu Asn Leu Pro
Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 100 105 110 Ser Gly Phe Asn
Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 115 120 125 Leu Glu
Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 130 135 140
Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 145
150 155 160 Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr
Thr Pro 165 170 175 Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu
Gln Ala Gln Asn 180 185 190 Gln Trp Leu Gln Asp Met Thr Thr His Leu
Ile Leu Arg Ser Phe Lys 195 200 205 Glu Phe Leu Gln Ser Ser Leu Arg
Ala Leu Arg Gln Met Gly Asp Leu 210 215 220 Ile Ser Val Pro Val Asp
Ser Arg Gly Ser Glu Gln Lys Leu Ile Ser 225 230 235 240 Glu Glu Asp
Leu <210> SEQ ID NO 3 <211> LENGTH: 222 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
M.Mulatta IL-6 1X FLAG <400> SEQUENCE: 3 Met Asn Ser Phe Ser
Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu Leu
Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Leu Pro 20 25 30 Gly
Glu Asp Ser Lys Asn Val Ala Ala Pro His Ser Gln Pro Leu Thr 35 40
45 Ser Ser Glu Arg Ile Asp Lys His Ile Arg Tyr Ile Leu Asp Gly Ile
50 55 60 Ser Ala Leu Arg Lys Glu Thr Cys Asn Arg Ser Asn Met Cys
Glu Ser 65 70 75 80 Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu
Pro Lys Met Ala 85 90 95 Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe
Asn Glu Asp Thr Cys Leu 100 105 110 Val Lys Ile Ile Thr Gly Leu Leu
Glu Phe Glu Val Tyr Leu Glu Tyr 115 120 125 Leu Gln Asn Arg Phe Glu
Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 130 135 140 Met Ser Thr Lys
Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 145 150 155 160 Leu
Asp Ala Ile Thr Thr Pro Glu Pro Thr Thr Asn Ala Ser Leu Leu 165 170
175 Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His
180 185 190 Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Asn Leu
Arg Ala 195 200 205 Leu Arg Gln Met Ala Ser Asp Tyr Lys Asp Asp Asp
Asp Lys 210 215 220 <210> SEQ ID NO 4 <211> LENGTH: 514
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: H.Sapiens IL23-p40:p19-6xHIS <400> SEQUENCE: 4 Met
Gly His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 1 5 10
15 Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val
20 25 30 Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val
Val Leu 35 40 45 Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp
Thr Leu Asp Gln 50 55 60 Ser Ser Glu Val Leu Gly Ser Gly Lys Thr
Leu Thr Ile Gln Val Lys 65 70 75 80 Glu Phe Gly Asp Ala Gly Gln Tyr
Thr Cys His Lys Gly Gly Glu Val 85 90 95 Leu Ser His Ser Leu Leu
Leu Leu His Lys Lys Glu Asp Gly Ile Trp 100 105 110 Ser Thr Asp Ile
Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 115 120 125 Leu Arg
Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 130 135 140
Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 145
150 155 160 Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr
Leu Ser 165 170 175 Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu
Tyr Ser Val Glu 180 185 190 Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala
Glu Glu Ser Leu Pro Ile 195 200 205 Glu Val Met Val Asp Ala Val His
Lys Leu Lys Tyr Glu Asn Tyr Thr 210 215 220 Ser Ser Phe Phe Ile Arg
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 225 230 235 240 Leu Gln Leu
Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 245 250 255 Glu
Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 260 265
270 Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg
275 280 285 Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys
Asn Ala 290 295 300 Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser
Ser Ser Trp Ser 305 310 315 320 Glu Trp Ala Ser Val Pro Cys Ser Val
Pro Gly Val Gly Val Pro Gly 325 330 335 Val Gly Arg Ala Val Pro Gly
Gly Ser Ser Pro Ala Trp Thr Gln Cys 340 345 350 Gln Gln Leu Ser Gln
Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro 355 360 365
Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr 370
375 380 Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln
Gly 385 390 395 400 Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile
His Gln Gly Leu 405 410 415 Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp
Ile Phe Thr Gly Glu Pro 420 425 430 Ser Leu Leu Pro Asp Ser Pro Val
Gly Gln Leu His Ala Ser Leu Leu 435 440 445 Gly Leu Ser Gln Leu Leu
Gln Pro Glu Gly His His Trp Glu Thr Gln 450 455 460 Gln Ile Pro Ser
Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu 465 470 475 480 Arg
Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala 485 490
495 Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro His His His His
500 505 510 His His <210> SEQ ID NO 5 <211> LENGTH: 511
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: M.Mulatta IL23-p40:p19-6xHIS <400> SEQUENCE: 5 Met
Ser Ala Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala Lys 1 5 10
15 Leu Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp
20 25 30 Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp
Thr Pro 35 40 45 Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser
Gly Glu Val Leu 50 55 60 Gly Ser Gly Lys Thr Leu Thr Ile Gln Val
Lys Glu Phe Gly Asp Ala 65 70 75 80 Gly Gln Tyr Thr Cys His Lys Gly
Gly Glu Ala Leu Ser His Ser Leu 85 90 95 Leu Leu Leu His Lys Lys
Glu Asp Gly Ile Trp Ser Thr Asp Val Leu 100 105 110 Lys Asp Gln Lys
Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 115 120 125 Lys Asn
Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 130 135 140
Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asn Pro 145
150 155 160 Gln Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg
Val Arg 165 170 175 Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys
Gln Glu Asp Ser 180 185 190 Ala Cys Pro Ala Ala Glu Glu Arg Leu Pro
Ile Glu Val Met Val Asp 195 200 205 Ala Ile His Lys Leu Lys Tyr Glu
Asn Tyr Thr Ser Ser Phe Phe Ile 210 215 220 Arg Asp Ile Ile Lys Pro
Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 225 230 235 240 Leu Lys Asn
Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 245 250 255 Trp
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Ile Gln Val 260 265
270 Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Ile Phe Thr Asp Lys
275 280 285 Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Phe Ser
Val Gln 290 295 300 Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu
Trp Ala Ser Val 305 310 315 320 Pro Cys Ser Arg Ser Val Pro Gly Val
Gly Val Pro Gly Val Gly Arg 325 330 335 Ala Val Pro Gly Gly Ser Ser
Pro Ala Trp Ala Gln Cys Gln Gln Leu 340 345 350 Ser Gln Lys Leu Cys
Thr Leu Ala Trp Ser Ala His Pro Leu Val Gly 355 360 365 His Met Asp
Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp Val 370 375 380 Pro
His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg Asp 385 390
395 400 Asn Ser Gln Phe Cys Leu Gln Arg Ile Arg Gln Gly Leu Ile Phe
Tyr 405 410 415 Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro
Ser Leu Leu 420 425 430 Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser
Leu Leu Gly Leu Ser 435 440 445 Gln Leu Leu Gln Pro Glu Gly His His
Trp Glu Thr Gln Gln Ile Pro 450 455 460 Ser Pro Ser Pro Ser Gln Pro
Trp Gln Arg Leu Leu Leu Arg Phe Lys 465 470 475 480 Ile Leu Arg Ser
Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val Phe 485 490 495 Ala His
Gly Ala Ala Thr Leu Ser Pro His His His His His His 500 505 510
<210> SEQ ID NO 6 <211> LENGTH: 119 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 6 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly
Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu
Ser Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys
Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Tyr Thr Asp Ser Ser Thr
Trp Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys
Thr Ser Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Ser Leu Thr
Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Lys Gly 85 90 95 Ser Thr
Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly Pro Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 <210> SEQ ID NO 7 <211>
LENGTH: 414 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 7 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg
tcgcctggtc acgcctggga cacccctgac actcacctgc 120 acagtctctg
gaatcgacct cagtagctac gacatgagct gggtccgcca ggctccaggg 180
aaggggctgg agtggatcgg atacatttat actgatagta gcacatggta cgcgaactgg
240 gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct
gaaaatgacc 300 agtctgacaa ccgaggacac ggccacctat ttctgtgcca
aaggtagtac cgattatgct 360 ttcgacactc ggttggatct ctggggccca
ggcaccctgg tcaccgtctc gagt 414 <210> SEQ ID NO 8 <211>
LENGTH: 111 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 8 Asn Ile Val Met Thr Gln Thr Pro
Ser Pro Val Ser Gly Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn
Cys Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 35 40 45 Tyr Arg
Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60
Ser Gly Ala Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 65
70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser
Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Val
Val Val Arg 100 105 110 <210> SEQ ID NO 9 <211> LENGTH:
333 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 9 aacatcgtga tgacccagac tccatccccc
gtgtctggag ctgtgggagg cacagtcacc 60 atcaattgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcagaaacca 120 gggcagcctc
ccaggctcct gatctacagg gcatccactc tgacatctgg ggtctcatcg 180
cggttcaaag gcagtggagc tgggacgcag ttcactctca ccatcagcgg cgtggagtgt
240 gccgatgctg ccacttacta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggtggtcgtc cgt 333 <210>
SEQ ID NO 10 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
10 Ser Tyr Asp Met Ser 1 5
<210> SEQ ID NO 11 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 11 Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp
Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 12 <211> LENGTH:
13 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 12 Gly Ser Thr Asp Tyr Ala Phe Asp
Thr Arg Leu Asp Leu 1 5 10 <210> SEQ ID NO 13 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 13 Gln Ala Ser Gln Ser Ile Ser Asn
Glu Leu Ser 1 5 10 <210> SEQ ID NO 14 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 14 Arg Ala Ser Thr Leu Thr Ser 1 5
<210> SEQ ID NO 15 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 15 Gln Gln Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10
<210> SEQ ID NO 16 <211> LENGTH: 121 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 16 Gln Ser Leu Gly Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser
Leu Ser Lys Asn Ala 20 25 30 Ile Ala Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Tyr Ala Gly Gly Ala
Thr Thr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Ser Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr
Thr Val Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Tyr 85 90 95 Ala
Gly Asp Ser Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp Leu Trp Gly 100 105
110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID
NO 17 <211> LENGTH: 363 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 17 cagtcgctgg
gggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc 60
tgcacagtct ctggattatc cctcagtaag aatgcaattg cctgggtccg ccaggctcca
120 gggaagggac tggaatggat cggaatcatt tatgctggtg gtgccacaac
ctacgcgagc 180 tgggcgaaag gccgattcac catctccaag tcctcgacca
cggtggatct gaagatcacc 240 agtccgacaa cagtggacac ggccacctat
ttctgtgcca gggaatatgc tggtgatagt 300 tattatactg gatacactca
gttggatctc tggggcccag gcaccctggt caccgtctcg 360 agt 363 <210>
SEQ ID NO 18 <211> LENGTH: 112 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
18 Ala Leu Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly
1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Leu Phe
Ser Ser 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val
Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr
Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr
Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr 85 90 95 Pro Asp Pro Ile
Tyr Gly Phe Gly Gly Gly Thr Lys Val Val Val Val 100 105 110
<210> SEQ ID NO 19 <211> LENGTH: 336 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 19 gcccttgtga tgacccagac tccagcctcc gtgtctgccg ctgtgggagg
cacagtgacc 60 atcaattgcc aggccagtga ggaccttttt agtagtttgg
cctggtttca gcagaaacca 120 gggcagcctc ccaaactcct gatctattct
gcatccactc tggcatctgg ggtcccatcg 180 cggttcagcg gcagtggatc
tgggacagaa ttcactctca ccatcagcga cctggaatgt 240 gccgatgctg
ccacttacta ctgtctaggc ctttactatt atcttactcc tgatcctatt 300
tatgggttcg gcggagggac caaggtggtg gtggtc 336 <210> SEQ ID NO
20 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 20 Lys Asn
Ala Ile Ala 1 5 <210> SEQ ID NO 21 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 21 Ile Ile Tyr Ala Gly Gly Ala Thr Thr Tyr
Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 22
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 22 Glu Tyr Ala Gly Asp
Ser Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp 1 5 10 15 <210> SEQ
ID NO 23 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 23 Gln Ala
Ser Glu Asp Leu Phe Ser Ser Leu Ala 1 5 10 <210> SEQ ID NO 24
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 24 Ser Ala Ser Thr Leu
Ala Ser 1 5 <210> SEQ ID NO 25 <211> LENGTH: 14
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 25 Leu Gly Leu Tyr Tyr Tyr Leu Thr Pro Asp
Pro Ile Tyr Gly 1 5 10 <210> SEQ ID NO 26 <211> LENGTH:
121 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 26 Gln Ser Val Glu Glu Ser Gly Gly
Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr
Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Met Thr Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ser
Tyr Val Tyr Ser Gly Asp Thr Trp Tyr Ala Ser Trp Val Lys 50 55 60
Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 65
70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Arg Val 85 90 95 Gly Asp Tyr Asp Asp Tyr Gly Ala His Asp Val Phe
Asp Ser Trp Gly 100 105 110
Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID NO
27 <211> LENGTH: 419 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 27 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagtctctg gattctccct cagtagctat gcaatgacct gggtccgcca
ggctccaggg 180 aaggggctgg aatggatcgg aaccagttat gtttatagtg
gtgacacatg gtacgcgagc 240 tgggtgaaag gccgattcac catctccaaa
acctcgacca cggtggatct gaaaatcacc 300 agtccgacaa ccgaggacac
ggccacgtat ttctgtgcca gagttgggga ttacgatgac 360 tatggtgccc
atgatgtttt tgattcctgg ggcccaggca ccctggtcac cgtctcgag 419
<210> SEQ ID NO 28 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 28 Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala
Val Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser
Ile Ser Ser Trp Leu 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Arg Pro Lys Leu Leu Leu Tyr 35 40 45 Arg Ala Ser Thr Leu Ala Ser
Gly Val Ser Ser Arg Phe Ser Gly Ser 50 55 60 Gly Tyr Gly Thr Glu
Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Glu 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Gly Gly Asn Val 85 90 95 Asp
Asn Ala Phe Gly Gly Gly Thr Lys Val Val Val Val Arg Thr 100 105 110
<210> SEQ ID NO 29 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 29 atggacacga gggcccccac ccagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgcct atgatatgac ccagactcca gcctctgtgg
aggtagctgt gggaggcaca 120 gtcaccatca agtgccaggc cagtgagagc
attagcagtt ggttatcctg gtatcagcag 180 aaaccagggc agcgtcccaa
gctcctgctc tacagggcat ccactctggc atctggggtc 240 tcatcgcggt
tcagcggcag tggatatggg acagagttca ctctcaccat cagcggcgtg 300
cagtgtgaag atgctgccac ttactactgt caacagggtt acactggtgg taatgttgat
360 aatgctttcg gcggagggac caaggtggtg gtcgtccgta cg 402 <210>
SEQ ID NO 30 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
30 Ser Tyr Ala Met Thr 1 5 <210> SEQ ID NO 31 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 31 Thr Ser Tyr Val Tyr Ser Gly Asp
Thr Trp Tyr Ala Ser Trp Val Lys 1 5 10 15 Gly <210> SEQ ID NO
32 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 32 Val Gly
Asp Tyr Asp Asp Tyr Gly Ala His Asp Val Phe Asp Ser 1 5 10 15
<210> SEQ ID NO 33 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 33 Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ser 1 5 10
<210> SEQ ID NO 34 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 34 Arg Ala Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
35 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 35 Gln Gln
Gly Tyr Thr Gly Gly Asn Val Asp Asn Ala 1 5 10 <210> SEQ ID
NO 36 <211> LENGTH: 115 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 36 Gln Ser
Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Gly Ser 1 5 10 15
Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Ser Leu Ser Ser Ser Gly 20
25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
Gly 35 40 45 Tyr Val Ser Ile Ala Asp Thr Ile Ser Tyr Ala Asn Trp
Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr
Val Asp Leu Glu Met 65 70 75 80 Thr Ser Leu Thr Thr Glu Asp Thr Ala
Thr Tyr Phe Cys Val Arg Gly 85 90 95 Phe Ile Thr Tyr Ser Gly Val
Leu Trp Gly Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115
<210> SEQ ID NO 37 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 37 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt
ccagtgtcag 60 tcggtggagg agtccggggg tcgtctggta gcgcctggag
gctccctgac actcacctgc 120 aaagcctctg gattctccct cagtagttct
ggagtgagtt gggtccgcca ggctccaggg 180 aagggactgg aatggatcgg
atacgttagt attgctgata ctatatccta cgcgaactgg 240 gcgaaaggcc
gattcaccat ctccaaaacc tcgtcgacca cggtggatct agaaatgacc 300
agtctgacaa ccgaggacac ggccacctat ttctgtgtca gaggtttcat tacttatagt
360 ggtgtcttgt ggggcccagg caccctggtc accgtctcga gt 402 <210>
SEQ ID NO 38 <211> LENGTH: 110 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
38 Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly Gly
1 5 10 15 Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Asn Val Tyr Ser
Asn Ala 20 25 30 Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro
Pro Lys Leu Leu 35 40 45 Ile Tyr Lys Ala Ser Lys Leu Ala Ser Gly
Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe
Thr Leu Thr Ile Ser Gly Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr
Tyr Tyr Cys Ala Gly Glu Tyr Glu Gly Gly 85 90 95 Ile Gly Thr Phe
Gly Gly Gly Thr Glu Val Val Val Val Arg 100 105 110 <210> SEQ
ID NO 39 <211> LENGTH: 399 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 39 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
acatttgcgc aagtgctgac ccagactcca gcctccgtgt ctgcagctgt gggaggcaca
120 gtcaccatca gttgccagtc cagtcagaat gtttatagta acgccttctt
atcctggtat 180 cagcagaaac cagggcagcc tcccaagctc ctgatctaca
aggcatccaa actggcatct 240 ggggtcccat cgcgattcag cggcagtggg
tctgggacac agttcactct caccatcagc 300 ggcgtccagt gtgacgatgc
tgccacttat tattgtgcag gcgaatatga aggtggtatc 360 ggtactttcg
gcggagggac cgaggtggtg gtggtccgt 399 <210> SEQ ID NO 40
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus
<400> SEQUENCE: 40 Ser Ser Gly Val Ser 1 5 <210> SEQ ID
NO 41 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 41 Tyr Val
Ser Ile Ala Asp Thr Ile Ser Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 42 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 42 Gly Phe Ile Thr Tyr Ser Gly Val Leu 1 5 <210>
SEQ ID NO 43 <211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
43 Gln Ser Ser Gln Asn Val Tyr Ser Asn Ala Phe Leu Ser 1 5 10
<210> SEQ ID NO 44 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 44 Lys Ala Ser Lys Leu Ala Ser 1 5 <210> SEQ ID NO
45 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 45 Ala Gly
Glu Tyr Glu Gly Gly Ile Gly Thr 1 5 10 <210> SEQ ID NO 46
<211> LENGTH: 118 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 46 Gln Ser Leu Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu
Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 20 25 30 Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40
45 Tyr Ile Tyr Thr Asp Thr Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
50 55 60 Arg Phe Ser Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys
Met Thr 65 70 75 80 Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Lys Gly Ser 85 90 95 Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115
<210> SEQ ID NO 47 <211> LENGTH: 411 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 47 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt
ccagtgtcag 60 tcgctggagg agtccggggg tcgcctggtc acgcctggga
cacccctgac actcacctgc 120 acagcctctg gattctccct cagtagctac
gacatgagct gggtccgcca ggctccaggg 180 aaggggctgg agtggatcgg
atacatttat actgatacta gtacatacta cgcgaactgg 240 gcgaaaggcc
gattctccat ctccaaaacc tcgaccacgg tggatctgaa aatgaccagt 300
ctgacagccg aggacacggc cacctatttc tgtgccaaag gtagtaccga ttatgctttc
360 gacactcggt tggatctgtg gggcccaggc accctggtca ccgtctcgag t 411
<210> SEQ ID NO 48 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 48 Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala
Met Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser
Ile Ser Asn Glu Leu 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Tyr 35 40 45 Arg Thr Ser Thr Leu Ala Ser
Gly Val Ser Ser Arg Phe Lys Gly Ser 50 55 60 Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys Ala 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp Val 85 90 95 Asp
Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Val Arg Thr 100 105 110
<210> SEQ ID NO 49 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 49 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgcct atgatatgac ccagactcca gcctctgtgg
aggtagctat gggaggcaca 120 gtcaccatca agtgccaggc cagtcagagc
attagcaatg aattatcctg gtatcagcag 180 aaaccagggc agcctcccaa
gctcctgatc tacaggacat ccactctggc atctggggtc 240 tcatcgcggt
tcaaaggcag tggatctggg acagagtaca ctctcaccat cagcggcgtg 300
gagtgtgccg atgctgccac ttactactgt caacagggtt ataatagtaa tgatgttgat
360 aatgttttcg gcggagggac cgaggtggtg gtcgtccgta cg 402 <210>
SEQ ID NO 50 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
50 Ser Tyr Asp Met Ser 1 5 <210> SEQ ID NO 51 <211>
LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 51 Tyr Ile Tyr Thr Asp Thr Ser Thr
Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 52
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 52 Gly Ser Thr Asp Tyr
Ala Phe Asp Thr Arg Leu Asp Leu 1 5 10 <210> SEQ ID NO 53
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 53 Gln Ala Ser Gln Ser
Ile Ser Asn Glu Leu Ser 1 5 10 <210> SEQ ID NO 54 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 54 Arg Thr Ser Thr Leu Ala Ser 1 5
<210> SEQ ID NO 55 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 55 Gln Gln Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10
<210> SEQ ID NO 56 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 56 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp
Leu Ser Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Tyr Thr Asp Ser Ser
Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80
Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Lys Gly Ser 85
90 95 Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly Pro Gly
Thr 100 105 110 Leu Val Thr Val Ser 115 <210> SEQ ID NO 57
<211> LENGTH: 410 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 57 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc
120 acagtctctg gaatcgacct cagtagctac gacatgagct gggtccgcca
ggctccaggg 180 aaggggctgg agtggatcgg atacatttat actgatagta
gcacatacta cgcgaactgg 240 gcgaaaggcc gattcaccat ctccaaaacc
tcgaccacgg tggatctgaa aatgaccagt 300 ctgacaaccg aggacacggc
cacctatttc tgtgccaaag gtagtaccga ttatgctttc 360 gacactcggt
tggatctctg gggcccaggc accctggtca ccgtctcgag 410 <210> SEQ ID
NO 58 <211> LENGTH: 112 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 58 Ala Tyr
Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Met Gly 1 5 10 15
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Glu 20
25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu
Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg
Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Gly Val Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln
Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly
Gly Thr Lys Val Val Val Val Arg Thr 100 105 110 <210> SEQ ID
NO 59 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 59 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
agatgtgcct atgatatgac ccagactcca gcctctgtgg aggtagctat gggaggcaca
120 gtcaccatca agtgccaggc cagtcagagc attagcaatg aattatcctg
gtatcagcag 180 aaaccagggc agcctcccaa gctcctgatc tacaggacat
ccactctggc atctggggtc 240 tcatcgcggt tcaaaggcag tggatctggg
acagagtaca ctctcaccat cagcggcgtg 300 gagtgtgccg atgctgccac
ttactactgt caacagggtt ataatagtaa tgatgttgat 360 aatgttttcg
gcggagggac caaggtggtg gtcgtccgta cg 402 <210> SEQ ID NO 60
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 60 Ser Tyr Asp Met Ser
1 5 <210> SEQ ID NO 61 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 61 Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn Trp
Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 62 <211> LENGTH:
13 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 62 Gly Ser Thr Asp Tyr Ala Phe Asp
Thr Arg Leu Asp Leu 1 5 10 <210> SEQ ID NO 63 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 63 Gln Ala Ser Gln Ser Ile Ser Asn
Glu Leu Ser 1 5 10 <210> SEQ ID NO 64 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 64 Arg Thr Ser Thr Leu Ala Ser 1 5
<210> SEQ ID NO 65 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 65 Gln Gln Gly Tyr Asn Ser Asn Asp Val Asp Asn Val 1 5 10
<210> SEQ ID NO 66 <211> LENGTH: 22 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rCH1R1 <400> SEQUENCE: 66 gccagtggga agactgacgg ag 22
<210> SEQ ID NO 67 <211> LENGTH: 21 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rVHL-F <400> SEQUENCE: 67 atggagactg ggctgcgctg g 21
<210> SEQ ID NO 68 <211> LENGTH: 25 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJH-R1 <400> SEQUENCE: 68 ggagacggtg accagggtgc ctggg
25 <210> SEQ ID NO 69 <211> LENGTH: 22 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer rJH6R <400> SEQUENCE: 69 tgaagagacg
gtgacgaggg tc 22 <210> SEQ ID NO 70 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rCk1R1 <400> SEQUENCE: 70
gcagctggtg ggaagatgag gac 23 <210> SEQ ID NO 71 <211>
LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer rVK5UTR <400>
SEQUENCE: 71 gccaggcagg acccagcatg gac 23 <210> SEQ ID NO 72
<211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rJK2-R
<400> SEQUENCE: 72 accaccacct yggtccctcc gcc 23 <210>
SEQ ID NO 73 <211> LENGTH: 24 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJK1-R <400> SEQUENCE: 73 gatttcyacc ttggtgccag ctcc
24
<210> SEQ ID NO 74 <211> LENGTH: 29 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJK24R <400> SEQUENCE: 74 gtttgatctc caccttggtc
cccgcaccg 29 <210> SEQ ID NO 75 <211> LENGTH: 22
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK2b9R <400> SEQUENCE: 75
acttacatag gatctccagc tc 22 <210> SEQ ID NO 76 <211>
LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer rJK5R <400>
SEQUENCE: 76 gtttgatctc cagcttggtt cc 22 <210> SEQ ID NO 77
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rVH1a-H3F
<400> SEQUENCE: 77 gcgataagct tcaccatgga gactgggctg cgctgg 36
<210> SEQ ID NO 78 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJH-XhoR ii <400> SEQUENCE: 78 gcgatctcga gacggtgacc
agggtgcctg gg 32 <210> SEQ ID NO 79 <211> LENGTH: 34
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJH6XhoIR <400> SEQUENCE: 79
gcatagctcg aggagacggt gacgagggtc cctg 34 <210> SEQ ID NO 80
<211> LENGTH: 35 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rVKF-Nco
<400> SEQUENCE: 80 gcgataccat ggacacgagg gcccccactc agctg 35
<210> SEQ ID NO 81 <211> LENGTH: 38 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer rJK2-BsiR2 <400> SEQUENCE: 81 gcgaacgtac ggacsaccac
cacctyggtc cctccgcc 38 <210> SEQ ID NO 82 <211> LENGTH:
38 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK1-BsiR2 <400> SEQUENCE:
82 gcgaacgtac gtttgatttc yaccttggtg ccagctcc 38 <210> SEQ ID
NO 83 <211> LENGTH: 39 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
rJK24BsiR <400> SEQUENCE: 83 gcatacgtac gtttgatctc caccttggtc
cccgcaccg 39 <210> SEQ ID NO 84 <211> LENGTH: 32
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer rJK2b9BsiR <400> SEQUENCE:
84 gcatacgtac gtaggatctc cagctcggtc cc 32 <210> SEQ ID NO 85
<211> LENGTH: 32 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer rJK5BsiR
<400> SEQUENCE: 85 gcatacgtac gtttgatctc cagcttggtt cc 32
<210> SEQ ID NO 86 <211> LENGTH: 115 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 86 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser
Leu Ser Ser Tyr Trp 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly
Gly Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ile Ala Thr Ser Ser Thr
Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 50 55 60 Phe Thr Ile Ser Arg
Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser 65 70 75 80 Leu Thr Thr
Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu Thr 85 90 95 Thr
Asp Tyr Asp Leu Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val 100 105
110 Ser Ser Ser 115 <210> SEQ ID NO 87 <211> LENGTH:
402 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 87 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcgctggagg agtccggggg
tcgcctggtc acgcctggga cacccctgac actcacctgc 120 acagcctctg
gattctccct cagtagctac tggatgacct gggtccgcca ggctccaggg 180
ggggggctgg agtggatcgg aaccattgct actagtagca catactacgc gagctgggca
240 aaaggccgat tcaccatctc cagaacctcg accacggtgg atctgaaaat
gaccagtctg 300 acaaccgagg acacggccac ctatttctgt gccagaggtc
ttactactga ttatgacttg 360 gatctctggg gaccagggac cctcgtcacc
gtctcctcga gt 402 <210> SEQ ID NO 88 <211> LENGTH: 108
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 88 Leu Val Met Thr Gln Thr Pro Ala Ser Val
Ser Ala Ala Val Gly Gly 1 5 10 15 Thr Val Thr Ile Asn Cys Gln Ala
Ser Glu Asp Ile Glu Ser Tyr Leu 20 25 30 Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Ala Ser Thr
Leu Thr Ser Gly Val Pro Ser Arg Phe Lys Gly Ser 50 55 60 Gly Ser
Gly Lys Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Arg Glu 65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr Thr Thr Val 85
90 95 Phe Gly Gly Gly Thr Lys Val Val Val Val Arg Thr 100 105
<210> SEQ ID NO 89 <211> LENGTH: 393 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 89 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgccc ttgtgatgac ccagactcca gcctccgtgt
ctgcagctgt gggaggcaca 120
gtcaccatca attgccaggc cagtgaggac attgaaagct atttagcctg gtatcagcag
180 aaaccagggc agcgtcccaa gctcctgatc tattctgcat ccactctgac
atctggggtc 240 ccatcgcggt tcaaaggcag tggatctggg aaacagttca
ctctcaccat cagcggcgtg 300 cagcgtgagg atgctgccac ctactactgt
ctaggtgctg atgatactac aactgttttc 360 ggcggaggga ccaaggtggt
ggtcgtccgt acg 393 <210> SEQ ID NO 90 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 90 Ser Tyr Trp Met Thr 1 5 <210> SEQ ID
NO 91 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 91 Thr Ile
Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 92 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 92 Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu 1 5 10
<210> SEQ ID NO 93 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 93 Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 1 5 10
<210> SEQ ID NO 94 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 94 Ser Ala Ser Thr Leu Thr Ser 1 5 <210> SEQ ID NO
95 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 95 Leu Gly
Ala Asp Asp Thr Thr Thr Val 1 5 <210> SEQ ID NO 96
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 96 Gln Ser Leu Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu
Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asp Tyr Asp 20 25 30 Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40
45 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp Ala Glu Gly
50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys
Met Ser 65 70 75 80 Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Arg Glu Ala 85 90 95 Pro Gly Tyr Ser Asp Gly Asp Ile Trp Gly
Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> SEQ
ID NO 97 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 97 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
tcgctggagg agtccggggg tcgcctggta acgcctggag gatccctgac actcacctgc
120 acagtctctg gaatcgacct cagtgactac gacatgagct gggtccgcca
ggctccaggg 180 aaggggctgg aatggatcgg aatcgtgtat gatattggta
ccatatacta cgcgccctgg 240 gcggaaggcc gattcaccat ctccaaaacc
tcgaccacgg tggatctgaa aatgagcagt 300 ctgacaaccg aggacacggc
cacctatttc tgtgccagag aggctcctgg atatagtgat 360 ggggatatct
ggggcccagg caccctggtc accgtctcga gt 402 <210> SEQ ID NO 98
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 98 Ala Leu Val Met Thr
Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val
Thr Ile Asn Cys Gln Ala Ser Glu Thr Val Asp Asn Asn 20 25 30 Lys
Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40
45 Leu Ile Tyr Gly Ala Ala Thr Leu Ala Ser Gly Val Pro Ser Arg Phe
50 55 60 Lys Gly Ser Gly Ser Gly Ala His Phe Thr Leu Thr Ile Ser
Asn Val 65 70 75 80 Gln Arg Glu Asp Ala Ala Thr Tyr Val Cys Gly Gly
Tyr Lys Asp Ser 85 90 95 Thr Asp Val Gly Phe Gly Gly Gly Thr Glu
Leu Glu Ile Leu Arg Thr 100 105 110 <210> SEQ ID NO 99
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 99 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
acatttgccc tggtgatgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca
120 gtcaccatca attgccaggc cagtgagact gttgataata acaagcgctt
atcgtggtat 180 cagcagaaac cagggcagcc tcccaagctc ctgatctatg
gtgcagccac tctggcatct 240 ggggtcccat cgcggttcaa aggcagtgga
tctggggcac acttcactct caccatcagc 300 aacgtgcagc gtgaggatgc
tgccacctac gtctgtggag gttataaaga tagtactgat 360 gttggttttg
gcggagggac cgagctggag atcctacgta cg 402 <210> SEQ ID NO 100
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 100 Asp Tyr Asp Met Ser
1 5 <210> SEQ ID NO 101 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 101 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp
Ala Glu Gly 1 5 10 15 <210> SEQ ID NO 102 <211> LENGTH:
10 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 102 Glu Ala Pro Gly Tyr Ser Asp Gly
Asp Ile 1 5 10 <210> SEQ ID NO 103 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 103 Gln Ala Ser Glu Thr Val Asp Asn Asn Lys
Arg Leu Ser 1 5 10 <210> SEQ ID NO 104 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 104 Gly Ala Ala Thr Leu Ala Ser 1 5
<210> SEQ ID NO 105 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 105 Gly Gly Tyr Lys Asp Ser Thr Asp Val Gly 1 5 10
<210> SEQ ID NO 106 <211> LENGTH: 113 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 106 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu
Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser
Gly Phe Ser Leu Asn Ser Tyr Ser 20 25 30 Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Gly Leu
Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe
Thr Ile Ser Gly Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala Thr 85
90 95 Tyr Ser Asp Asp Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val
Ser 100 105 110 Ser <210> SEQ ID NO 107 <211> LENGTH:
396 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 107 atggagactg ggctgcgctg
gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg
agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc 120
acagtctctg gattctccct caatagttat tcaatgagct gggtccgcca ggctccaggg
180 aaggggctgg aatggatcgg agtcattggt cttggtggta gcgcatacta
cgcgagctgg 240 gcgaaaggcc gattcaccat ctccggagcc tcgaccacgg
tggatctgaa aatcaccagt 300 ccgacaaccg aggacacggc cacctatttc
tgtgccagag ccacttatag tgatgataat 360 atctggggcc caggcaccct
ggtcaccgtc tcgagt 396 <210> SEQ ID NO 108 <211> LENGTH:
108 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 108 Asp Val Val Met Thr Gln Thr Pro
Ser Ser Thr Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys
Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Arg Pro Lys Pro Leu Ile 35 40 45 Val Arg
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60
Asn Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Arg 65
70 75 80 Glu Asp Ala Ala Ala Tyr Tyr Cys Leu Gly Gly Asp Gly Asn
Val Ser 85 90 95 Asn Phe Gly Gly Gly Thr Lys Val Val Val Val Arg
100 105 <210> SEQ ID NO 109 <211> LENGTH: 390
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 109 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 agatgtgatg ttgtgatgac
ccagactcca tcctccacgt ctgcagctgt gggaggcaca 120 gtcaccatca
agtgccaggc cagtcagagc attagcagtt ggttatcctg gtatcagcag 180
aaaccagggc agcgtcccaa gcccctgatc gtcagggcat ccactctggc atctggggtc
240 ccatcgcggt tcaaaggcaa tagatctggg acagagtaca ctctcaccat
cagcggcgtg 300 cagcgtgagg atgctgccgc ctactactgt ctaggtggtg
atggtaatgt ttctaatttc 360 ggcggaggga ccaaggtggt ggtcgtccgt 390
<210> SEQ ID NO 110 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 110 Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Ser Met Ser 1
5 10 <210> SEQ ID NO 111 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 111 Val Ile Gly Leu Gly Gly Ser Ala Tyr Tyr Ala Ser Trp
Ala Lys 1 5 10 15 <210> SEQ ID NO 112 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 112 Ala Thr Tyr Ser Asp Asp Asn Ile 1 5
<210> SEQ ID NO 113 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 113 Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ser 1 5 10
<210> SEQ ID NO 114 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 114 Arg Ala Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
115 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 115 Leu Gly
Gly Asp Gly Asn Val Ser Asn 1 5 <210> SEQ ID NO 116
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 116 Gln Glu Gln Leu Lys
Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 1 5 10 15 Ser Leu Thr
Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 20 25 30 Asp
Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40
45 Gly Tyr Ile Tyr Arg Gly Ser Pro Tyr Tyr Ala Asp Trp Ala Lys Gly
50 55 60 Arg Phe Thr Ile Ser Ser Thr Ser Thr Thr Val Gly Leu Lys
Ile Thr 65 70 75 80 Ser Pro Thr Thr Val Asp Thr Ala Thr Tyr Phe Cys
Thr Arg Asn Leu 85 90 95 Tyr Ser Val Asn Val Leu Trp Gly Pro Gly
Thr Leu Val Thr Val Ser 100 105 110 <210> SEQ ID NO 117
<211> LENGTH: 395 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 117 atggagactg
ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
gagcaactga aggagtccgg aggaggcctg gtaacgcctg gaggatccct gacactcacc
120 tgcacagtct ctggattctc cctcagtacc tacgacataa actgggtccg
ccaggctcca 180 gggaaggggc tggagtggat cggatatatt tatcgtggta
gcccatacta cgcggactgg 240 gcgaagggcc gattcaccat ctccagcacc
tcgaccacgg tgggtctgaa gatcaccagt 300 ccgacaaccg tggacacggc
cacctatttc tgtaccagaa acctttatag tgttaatgtc 360 ctctggggcc
caggcaccct ggtcaccgtc tcgag 395 <210> SEQ ID NO 118
<211> LENGTH: 109 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 118 Leu Val Met Thr Gln
Thr Pro Ser Ser Thr Ser Ala Ala Val Gly Asp 1 5 10 15 Thr Val Thr
Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu 20 25 30 Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 35 40
45 Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser
50 55 60 Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Val Gln
Arg Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ser
Asn Thr Ile Arg 85 90 95 Thr Phe Gly Ala Gly Thr Lys Val Glu Ile
Lys Arg Thr 100 105 <210> SEQ ID NO 119 <211> LENGTH:
396 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 119 atggacacga gggcccccac
tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
agatgtgccc tggtgatgac ccagactcca tcctccacat ctgccgctgt gggagacaca
120 gtcaccatca agtgccaggc cagtcagagc attagtagta gattagcctg
gtatcagcag 180 aaaccagggc agcctcccaa gctcctgatc tattctgcat
ccactctggc atctggggtc 240 ccatcgcgat tcaaaggcag tggatctggg
acagactaca ctctcaccat cagcggcgtg 300 cagcgtgagg atgctgccac
ctactactgt ctaggtagtt atagtaatac tattaggaca 360 ttcggagctg
gcaccaaggt agaaatcaaa cgtacg 396 <210> SEQ ID NO 120
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 120 Thr Tyr Asp Ile Asn
1 5 <210> SEQ ID NO 121 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 121 Tyr Ile Tyr Arg Gly Ser Pro Tyr Tyr Ala Asp Trp Ala
Lys Gly 1 5 10 15 <210> SEQ ID NO 122 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 122 Asn Leu Tyr Ser Val Asn Val Leu 1 5
<210> SEQ ID NO 123 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 123 Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu Ala 1 5 10
<210> SEQ ID NO 124 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 124 Ser Ala Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO
125 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 125 Leu Gly
Ser Tyr Ser Asn Thr Ile Arg Thr 1 5 10 <210> SEQ ID NO 126
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 126 Gln Ser Leu Glu Glu
Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu
Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asp Tyr Asp 20 25 30 Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40
45 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp Ala Glu Gly
50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Lys
Met Ser 65 70 75 80 Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
Ala Thr Glu Ala 85 90 95 Pro Gly Tyr Ser Asp Gly Asp Ile Trp Gly
Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> SEQ
ID NO 127 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 127
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag
60 tcgctggagg agtccggggg tcgcctggta acgcctggag gatccctgac
actcacctgc 120 acagtctctg gaatcgacct cagtgactac gacatgagct
gggtccgcca ggctccaggg 180 aaggggctgg aatggatcgg aatcgtgtat
gatattggta ccatatatta tgcgccctgg 240 gcggaaggcc gattcaccat
ctccaaaacc tcgaccacga tggatctgaa aatgagcagt 300 ctgacaaccg
aggacacggc cacttatttc tgtgccacag aggctcctgg atatagtgat 360
ggggatatct ggggcccagg caccctggtc accgtctcga gt 402 <210> SEQ
ID NO 128 <211> LENGTH: 110 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 128 Leu Val
Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly Gly 1 5 10 15
Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Thr Val Gly Asn Asn Asn 20
25 30 Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu
Leu 35 40 45 Ile Tyr Gly Ala Ala Thr Leu Ala Ser Gly Val Pro Ser
Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Ala His Phe Thr Leu Thr
Ile Ser Asn Val Gln 65 70 75 80 Arg Glu Asp Val Ala Thr Tyr Val Cys
Gly Gly Tyr Lys Asp Ser Thr 85 90 95 Asp Val Gly Phe Gly Gly Gly
Thr Glu Leu Glu Ile Leu Arg 100 105 110 <210> SEQ ID NO 129
<211> LENGTH: 399 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 129 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
acatttgccc tggtgatgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca
120 gtcaccatca attgccaggc cagtgagact gttggtaata acaaccgctt
atcgtggtat 180 caacagaaac cagggcagcc tcccaagctc ctgatctatg
gtgcagccac tctggcatct 240 ggggtcccat cgcggttcaa aggcagtgga
tctggggcac acttcactct caccatcagc 300 aacgtgcagc gtgaggatgt
tgccacctac gtctgtggag gttataaaga tagtactgat 360 gttggttttg
gcggagggac cgagctggag atcctacgt 399 <210> SEQ ID NO 130
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 130 Asp Tyr Asp Met Ser
1 5 <210> SEQ ID NO 131 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 131 Ile Val Tyr Asp Ile Gly Thr Ile Tyr Tyr Ala Pro Trp
Ala Glu Gly 1 5 10 15 <210> SEQ ID NO 132 <211> LENGTH:
10 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 132 Glu Ala Pro Gly Tyr Ser Asp Gly
Asp Ile 1 5 10 <210> SEQ ID NO 133 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 133 Gln Ala Ser Glu Thr Val Gly Asn Asn Asn
Arg Leu Ser 1 5 10 <210> SEQ ID NO 134 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 134 Gly Ala Ala Thr Leu Ala Ser 1 5
<210> SEQ ID NO 135 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 135 Gly Gly Tyr Lys Asp Ser Thr Asp Val Gly 1 5 10
<210> SEQ ID NO 136 <211> LENGTH: 119 <212> TYPE:
PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
136 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr
Tyr Thr 20 25 30 Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu
Glu Trp Ile Gly 35 40 45 Ala Ile Ser Tyr Asp Gly Gly Thr Ala Tyr
Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser
Thr Thr Val Asp Leu Gln Ile Ala 65 70 75 80 Ser Pro Thr Thr Glu Asp
Thr Ala Thr Tyr Phe Cys Ala Arg Gly Phe 85 90 95 Tyr Val Tyr Ala
Tyr Ile Gly Asp Ala Phe Asp Pro Trp Gly Pro Gly 100 105 110 Thr Leu
Val Thr Val Ser Ser 115 <210> SEQ ID NO 137 <211>
LENGTH: 414 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 137 atggagactg ggctgcgctg
gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcgctggagg
agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc 120
acagtctctg gattctccct cagtacctat acaatgaact gggtccgcca gtctccaggg
180 aaggggctgg aatggatcgg agccattagt tatgatggtg gcacagccta
cgcgaactgg 240 gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg
tggatctgca aatcgccagt 300 ccgacaaccg aggacacggc cacctatttc
tgtgccagag gtttttatgt ttatgcttat 360 attggggatg ctttcgatcc
ctggggccca ggcaccctgg tcaccgtctc gagt 414 <210> SEQ ID NO 138
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 138 Ala Val Leu Thr Gln
Thr Pro Ser Pro Val Ser Ala Thr Val Gly Gly 1 5 10 15 Thr Val Thr
Ile Lys Cys Gln Ser Ser Gln Thr Val Tyr Lys Asn Asn 20 25 30 Leu
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40
45 Ile Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly
Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly
Tyr Asp Asp Asp 85 90 95 Ala Asp Thr Ala Phe Gly Gly Gly Thr Glu
Val Val Val Val Arg Thr 100 105 110 <210> SEQ ID NO 139
<211> LENGTH: 405 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 139 atggacacga
gggcccccac tcagctgctg gggctcctgc tggtctggct cccaggtgcc 60
acatttgcag ccgtgctgac ccagacacca tcgcccgtgt ctgcaactgt gggaggcact
120 gtcaccatca agtgccagtc cagtcagact gtttataaaa acaacctctt
atcctggtat 180 cagcagaaac ccgggcagcc tcccaagctc ctgatctatc
tggcatccac tctggcatct 240 ggggtcccat cgcggttcag cggcagtgga
tctgggacac agttcactct caccatcagc 300 ggcgtgcagt gtgacgatgc
tgccacttac tactgtctag gcggttatga tgatgacgct 360 gatactgctt
tcggcggagg gaccgaggtg gtggtggtcc gtacg 405 <210> SEQ ID NO
140 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 140 Thr Tyr
Thr Met Asn 1 5 <210> SEQ ID NO 141 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 141 Ala Ile Ser Tyr Asp Gly Gly Thr Ala Tyr
Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 142
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 142 Gly Phe Tyr Val Tyr
Ala Tyr Ile Gly Asp Ala Phe Asp Pro 1 5 10 <210> SEQ ID NO
143 <211> LENGTH: 13 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 143 Gln Ser
Ser Gln Thr Val Tyr Lys Asn Asn Leu Leu Ser 1 5 10 <210> SEQ
ID NO 144 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 144 Leu Ala
Ser Thr Leu Ala Ser 1 5 <210> SEQ ID NO 145 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 145 Leu Gly Gly Tyr Asp Asp Asp Ala
Asp Thr Ala 1 5 10 <210> SEQ ID NO 146 <211> LENGTH:
120 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 146 Gln Ser Val Glu Glu Ser Gly Gly
Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr
Val Ser Gly Phe Ser Leu Ser Val Tyr Pro 20 25 30 Ile Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Gly Trp Ile Gly 35 40 45 Ile Ile
Asn Asp Val Asp Asp Thr Ala Tyr Ser Ala Trp Ala Lys Gly 50 55 60
Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Asp Leu Lys Ile 65
70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala
Arg Gly 85 90 95 Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp Ala Phe Asp
Pro Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 147 <211> LENGTH: 417 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 147 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc
tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc
acgcctggga cacccctgac actcacctgc 120 acagtctctg gattctccct
cagtgtatat ccaataaact gggtccgcca ggctccaggg 180 aaggggctgg
gatggatcgg gattattaat gatgttgatg acacagccta ctcagcctgg 240
gcgaaaggcc gattcaccat ctccaaagcc tcgtcgacca cggtggattt gaaaatcacc
300 agtccgacaa ccgaagacac ggccacctat ttctgtgcca gaggttattt
gagttatgct 360 tatgctggag atgctttcga tccctggggc ccaggcaccc
tggtcaccgt ctcgagt 417 <210> SEQ ID NO 148 <211>
LENGTH: 110 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 148 Ala Val Leu Thr Gln Thr Pro Ser
Pro Val Ser Ala Ala Val Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys
Gln Ser Ser Gln Ser Ile Tyr Asn Asn Asn 20 25 30 Leu Leu Ser Trp
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 35 40 45 Ile His
Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 50 55 60
Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 65
70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp
Asp Asp 85 90 95 Ala Asp Thr Ala Phe Gly Gly Gly Thr Glu Val Val
Val Val 100 105 110 <210> SEQ ID NO 149 <211> LENGTH:
405 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus
<400> SEQUENCE: 149 atggacacga gggcccccac tcagctgctg
gggctcctgc tgctctggct cccaggtgcc 60 acatttgcag ccgtgctgac
ccagacacca tcgcccgtgt ctgcagctgt gggaggcaca 120 gtcaccatca
agtgccagtc cagtcagagt atttataata acaacctctt atcctggtat 180
cagcagaaac cagggcagcc tcccagactc ctgatccatt ttgcatccac tctggcatct
240 ggggtcccag ataggttcag cggcagtgga tctgggacac agttcactct
caccatcagc 300 ggcgtacagt gtgacgatgc tgccacttat tactgtctag
gcggttatga tgatgatgct 360 gatactgctt tcggcggagg gaccgaggtg
gtggtcgtcc gtacg 405 <210> SEQ ID NO 150 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 150 Val Tyr Pro Ile Asn 1 5 <210> SEQ
ID NO 151 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 151 Ile Ile
Asn Asp Val Asp Asp Thr Ala Tyr Ser Ala Trp Ala Lys Gly 1 5 10 15
<210> SEQ ID NO 152 <211> LENGTH: 14 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 152 Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp Ala Phe Asp
Pro 1 5 10 <210> SEQ ID NO 153 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 153 Gln Ser Ser Gln Ser Ile Tyr Asn Asn Asn
Leu Leu Ser 1 5 10 <210> SEQ ID NO 154 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 154 Phe Ala Ser Thr Leu Ala Ser 1 5
<210> SEQ ID NO 155 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 155 Leu Gly Gly Tyr Asp Asp Asp Ala Asp Thr Ala 1 5 10
<210> SEQ ID NO 156 <211> LENGTH: 114 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 156 Gln Glu Leu Lys Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Gly Ser 1 5 10 15 Leu Thr Leu Ser Cys Thr Ala Ser Gly Leu Thr
Leu Gly Ser Tyr Ser 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Met Gly 35 40 45 Val Ile Gly Val Gly Gly Thr
Leu Asn Tyr Ala Ser Trp Ala Gln Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Pro Ser Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Ser Leu
Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 85 90 95 Thr
Tyr Ser Gly Asp Ser Ile Trp Gly Pro Gly Thr Leu Val Thr Val 100 105
110 Ser Ser <210> SEQ ID NO 157 <211> LENGTH: 399
<212> TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 157 atggagactg ggctgcgctg gcttctcctg
gtcgctgtgc tcaaaggtgt ccaatgtcag 60 gagctgaagg agtccggggg
tcgcctggtc acgcctgggg gatccctgac actctcctgc 120 actgcctctg
gactcaccct tggtagttat tcaatgacct gggtccgcca ggctccaggg 180
aaggggctgg aatggatggg agtcattggt gttggtggta ccctaaacta cgcgagctgg
240 gcgcaaggcc gattcaccat ctccaaaccc tcgtcgacca cggtggatct
gaaaatgacc 300 agtctgacaa ccgaggacac ggccacctat ttctgtgcca
gaggcactta tagtggtgat 360 agtatctggg gcccaggcac cctggtcacc
gtctcgagt 399 <210> SEQ ID NO 158 <211> LENGTH: 131
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 158 Met Asp Thr Arg Ala Pro Thr Gln Leu Leu
Gly Leu Leu Leu Leu Trp 1 5 10 15 Leu Pro Gly Ala Arg Cys Asp Val
Val Met Thr Gln Thr Pro Ser Ser 20 25 30 Thr Ser Ala Ala Val Gly
Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 35 40 45 Gln Ser Ile Ser
Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 50 55 60 Pro Pro
Lys Pro Leu Ile Val Arg Ala Ser Ile Leu Thr Ser Gly Val 65 70 75 80
Pro Ser Arg Phe Lys Gly Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr 85
90 95 Ile Ser Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu
Gly 100 105 110 Gly Asp Gly His Val Ser Asn Phe Gly Gly Gly Thr Glu
Leu Glu Ile 115 120 125 Leu Arg Thr 130 <210> SEQ ID NO 159
<211> LENGTH: 393 <212> TYPE: DNA <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 159 atggacacga
gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
agatgtgatg ttgtgatgac ccagactcca tcctccacgt ctgcagctgt gggaggcaca
120 gtcaccatca agtgccaggc cagtcagagc attagtagtt ggttggcctg
gtatcaacag 180 aaaccagggc agcctcccaa gcccctgatc gtcagagcgt
ccattctgac atctggggtc 240 ccatcgcggt tcaaaggcag tagatctggg
acagagtaca ctctcaccat cagcggcgtg 300 cagcgtgagg atgctgccac
ctactactgt ctaggtggtg atggtcatgt ttctaatttc 360 ggcggaggga
ccgagctgga gatcctacgt acg 393 <210> SEQ ID NO 160 <211>
LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 160 Thr Ala Ser Gly Leu Thr Leu Gly
Ser Tyr Ser Met Thr 1 5 10 <210> SEQ ID NO 161 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 161 Val Ile Gly Val Gly Gly Thr Leu
Asn Tyr Ala Ser Trp Ala Gln 1 5 10 15 <210> SEQ ID NO 162
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 162 Gly Thr Tyr Ser Gly
Asp Ser Ile 1 5 <210> SEQ ID NO 163 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 163 Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu
Ala 1 5 10 <210> SEQ ID NO 164 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 164 Arg Ala Ser Ile Leu Thr Ser 1 5
<210> SEQ ID NO 165 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 165 Leu Gly Gly Asp Gly His Val Ser Asn 1 5
<210> SEQ ID NO 166 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 166 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro
Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser
Leu Ser Gly Tyr Thr 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly
Glu Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Ser Ser Gly Asn
Thr Tyr Tyr Ala Ser Trp Val Lys Gly 50 55 60 Arg Phe Thr Ile Ser
Lys Thr Ser Thr Thr Val Asp Leu Lys Met Ile 65 70 75 80 Ser Pro Thr
Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Gly
Ala Tyr Ile Ser Asp Tyr Phe Asn Val Trp Gly Pro Gly Thr Leu 100 105
110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 167 <211>
LENGTH: 408 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 167 atggagactg ggctgcgctg
gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60 tcggtggagg
agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc 120
gcagtctctg gattctccct cagtggctat acaatgatct gggtccgcca ggctccaggg
180 gaggggctgg aatggatcgg aatcattagt agtagtggta acacatacta
cgcgagctgg 240 gtgaaaggcc gattcaccat ctccaaaacc tcgaccacgg
tggatctgaa aatgattagt 300 ccgacaaccg aggacacggc cacctatttc
tgtgccagag gtagtggtgc ttatatttct 360 gactacttta acgtctgggg
cccaggcacc ctggtcaccg tctcgagt 408 <210> SEQ ID NO 168
<211> LENGTH: 109 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 168 Phe Glu Leu Thr Gln
Thr Pro Ser Ser Val Glu Ala Ala Val Glu Gly 1 5 10 15 Thr Val Thr
Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu 20 25 30 Ser
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 35 40
45 Ser Ala Ser Lys Leu Ala Pro Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60 Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Gly Asp Leu Glu
Cys Ala 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp
Val Asn Ala Gly 85 90 95 Tyr Gly Phe Gly Gly Gly Thr Glu Val Val
Val Val Arg 100 105 <210> SEQ ID NO 169 <211> LENGTH:
396 <212> TYPE: DNA <213> ORGANISM: Oryctolagus
cuniculus <400> SEQUENCE: 169 atggacacga gggcccccac
tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60 agatgtgcat
tcgaattgac ccagactcca tcctccgtgg aggcagctgt ggaaggcaca 120
gtcaccatca agtgccaggc cagtcagagc attgatagtt ggttatcctg gtatcagcag
180 aaaccagggc agcctcccaa gctcctgatc tattctgcat ccaaactggc
acctggggtc 240 ccatcgcggt tcagcggcag tggatctggg acacagttca
ctctcaccat cggcgacctg 300 gagtgtgccg atgctgccac ttactactgt
caaagctatt atgatgttaa tgctggttat 360 ggtttcggcg gagggaccga
ggtggtggtc gtccgt 396 <210> SEQ ID NO 170 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 170 Gly Tyr Thr Met Ile 1 5 <210> SEQ
ID NO 171 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 171 Ile Ile
Ser Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Val Lys Gly 1 5 10 15
<210> SEQ ID NO 172 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 172 Gly Ser Gly Ala Tyr Ile Ser Asp Tyr Phe Asn Val 1 5
10 <210> SEQ ID NO 173 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 173 Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu Ser 1 5 10
<210> SEQ ID NO 174 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 174 Ser Ala Ser Lys Leu Ala Pro 1 5 <210> SEQ ID NO
175 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 175 Gln Ser
Tyr Tyr Asp Val Asn Ala Gly Tyr Gly 1 5 10 <210> SEQ ID NO
176 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 176 Gln Ser
Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Thr 20
25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile
Gly 35 40 45 Ile Ile Ser Ala Gly Gly Ser Ala Tyr Tyr Ala Ser Trp
Val Asn Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val
Asp Leu Lys Met Thr 65 70 75 80 Ser Pro Thr Thr Gly Asp Thr Ala Thr
Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Gly Thr Tyr Thr Ser Asp Tyr
Phe Asn Ile Trp Gly Pro Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 <210> SEQ ID NO 177 <211> LENGTH: 408 <212>
TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 177 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc
tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc
acgcctggga cacccctgac actcacctgc 120 acagtctctg gattctccct
cagtagctat acaatgatct gggtccgcca ggctccaggg 180 gaggggctgg
aatggatcgg aatcattagt gctggtggta gcgcatacta cgcgagctgg 240
gtgaatggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatgaccagt
300 ccgacaaccg gggacacggc cacctatttc tgtgccagag gtagtggtac
ttatacttcc 360 gactacttta acatctgggg cccaggcacc ctggtcaccg tctcgagt
408 <210> SEQ ID NO 178 <211> LENGTH: 109 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 178 Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Glu Ala Ala
Val Gly Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser
Ile Asp Ser Trp Leu 20 25 30 Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Ala Ser Lys Leu Ala Thr
Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Gln
Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Ala Asn Ala Gly 85 90 95
Tyr Gly Phe Gly Gly Gly Thr Lys Val Val Val Val Arg 100 105
<210> SEQ ID NO 179 <211> LENGTH: 396 <212> TYPE:
DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 179 atggacacga gggcccccac tcagctgctg gggctcctgc
tgctctggct cccaggtgcc 60 agatgtgcat tcgaattgac ccagactcca
tcctccgtgg aggcagctgt gggaggcaca 120 gtcaccatca aatgccaggc
cagtcagagc attgatagtt ggttagcctg gtatcagcag 180 aaaccagggc
agcctcccaa gctcctgatc tattctgcat ccaaactggc aactggggtc 240
ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcgacctg
300 gagtgtgccg atgctgccac ttactactgt caaagttatt atgatgctaa
tgctggttat 360 ggtttcggcg gagggaccaa ggtggtggtg gtccgt 396
<210> SEQ ID NO 180 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 180 Ser Tyr Thr Met Ile 1 5 <210> SEQ ID NO 181
<211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 181 Ile Ile Ser Ala Gly
Gly Ser Ala Tyr Tyr Ala Ser Trp Val Asn Gly 1 5 10 15 <210>
SEQ ID NO 182 <211> LENGTH: 12 <212> TYPE: PRT
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
182 Gly Ser Gly Thr Tyr Thr Ser Asp Tyr Phe Asn Ile 1 5 10
<210> SEQ ID NO 183 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 183 Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu Ala 1 5 10
<210> SEQ ID NO 184 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 184 Ser Ala Ser Lys Leu Ala Thr 1 5 <210> SEQ ID NO
185 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 185 Gln Ser
Tyr Tyr Asp Ala Asn Ala Gly Tyr Gly 1 5 10 <210> SEQ ID NO
186 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 186 Gln Ser
Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15
Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Asp Tyr Thr 20
25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile
Gly 35 40 45 Ile Ile Ser Ser Ser Gly Asn Thr Tyr Tyr Ala Thr Trp
Val Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val
Asp Leu Lys Met Ile 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr
Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Gly Ala Tyr Ile Ser Asp Tyr
Phe Asn Val Trp Gly Pro Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 <210> SEQ ID NO 187 <211> LENGTH: 408 <212>
TYPE: DNA <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 187 atggagactg ggctgcgctg gcttctcctg gtcgctgtgc
tcaaaggtgt ccagtgtcag 60 tcggtggagg agtccggggg tcgcctggtc
acgcctggga cacccctgac actcacctgc 120 gcagtctctg gattctccct
cagtgactat acaatgatct gggtccgcca ggctccaggg 180 gaggggctgg
aatggatcgg aatcattagt agtagtggta acacatacta cgcgacctgg 240
gtgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatgattagt
300 ccgacaaccg aggacacggc cacctatttc tgtgccagag gtagtggtgc
ttatatttct 360 gactacttta acgtctgggg cccaggcacc ctggtcaccg tctcgagt
408 <210> SEQ ID NO 188 <211> LENGTH: 109 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 188 Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Glu Ala Ala
Val Glu Gly 1 5 10 15 Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser
Ile Asp Ser Trp Leu 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Tyr 35 40 45 Ala Ala Ser Lys Leu Ala Thr
Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Gln
Phe Thr Leu Thr Ile Gly Asp Leu Glu Cys Ala 65 70 75 80 Asp Ala Ala
Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Val Asn Ala Gly 85 90 95 Tyr
Gly Phe Gly Gly Gly Thr Glu Val Val Val Val Arg 100 105 <210>
SEQ ID NO 189 <211> LENGTH: 396 <212> TYPE: DNA
<213> ORGANISM: Oryctolagus cuniculus <400> SEQUENCE:
189 atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
cccaggtgcc 60 agatgtgcat tcgaattgac ccagactcca tcctccgtgg
aggcagctgt ggaaggcaca 120 gtcaccatca agtgccaggc cagtcagagc
attgatagtt ggttatcctg gtatcagcag 180 aaaccagggc agcctcccaa
gctcctgatc tatgctgcat ccaaactggc aactggggtc 240 ccatcgcggt
tcagcggcag tggatctggg acacagttca ctctcaccat cggcgacctg 300
gagtgtgccg atgctgccac ttactactgt caaagctatt atgatgttaa tgctggttat
360 ggtttcggcg gagggaccga ggtggtggtc gtccgt 396 <210> SEQ ID
NO 190 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 190 Asp Tyr
Thr Met Ile 1 5 <210> SEQ ID NO 191 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus
<400> SEQUENCE: 191 Ile Ile Ser Ser Ser Gly Asn Thr Tyr Tyr
Ala Thr Trp Val Lys Gly 1 5 10 15 <210> SEQ ID NO 192
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 192 Gly Ser Gly Ala Tyr
Ile Ser Asp Tyr Phe Asn Val 1 5 10 <210> SEQ ID NO 193
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 193 Gln Ala Ser Gln Ser
Ile Asp Ser Trp Leu Ser 1 5 10 <210> SEQ ID NO 194
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Oryctolagus cuniculus <400> SEQUENCE: 194 Ala Ala Ser Lys Leu
Ala Thr 1 5
<210> SEQ ID NO 195 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 195 Gln Ser Tyr Tyr Asp Val Asn Ala Gly Tyr Gly 1 5 10
<210> SEQ ID NO 196 <211> LENGTH: 121 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 9C8 VH
AA <400> SEQUENCE: 196 Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr
Val Ser Gly Ile Asp Leu Ser Ser Tyr 20 25 30 Asp Leu Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Tyr Ile
Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70
75 80 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
Ala 85 90 95 Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 197 <211> LENGTH: 363 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 9C8 VH
nt <400> SEQUENCE: 197 gaggtgcagc tggtggagtc tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggaat
cgacctcagt agctacgacc tcagctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgggctac atttatactg atagtagcac atactacgcg 180
aactgggcga agggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg
240 caactcaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtagtacc 300 gattatgctt tcgacactcg gttggatctc tggggccagg
gcaccctggt caccgtctcg 360 agc 363 <210> SEQ ID NO 198
<211> LENGTH: 110 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 9C8 VL AA <400>
SEQUENCE: 198 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val
Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
<210> SEQ ID NO 199 <211> LENGTH: 330 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 9C8 VL
nt <400> SEQUENCE: 199 gacatccagc tcacccagtc tccatcctct
gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagg acatccactc tggcatctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggaaatcaaa 330 <210> SEQ
ID NO 200 <211> LENGTH: 32 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
scFv-NotF <400> SEQUENCE: 200 gcgatagcgg ccgcaccacc
atggaggctc cc 32 <210> SEQ ID NO 201 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer JHXhoR <400> SEQUENCE: 201
gctatactcg agacggtgac cagggtgccc tggcccc 37 <210> SEQ ID NO
202 <211> LENGTH: 53 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
DPK8F1 <400> SEQUENCE: 202 gacatccagt tgacccagtc tccatccttt
ctgtctgcat ctgtaggaga cag 53 <210> SEQ ID NO 203 <211>
LENGTH: 32 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer DPK8-AgeF <400>
SEQUENCE: 203 gacacaaccg gtgacatcca gttgacccag tc 32 <210>
SEQ ID NO 204 <211> LENGTH: 48 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 9C8-H1F <400> SEQUENCE: 204 gaatcgacct cagtagctac
gacatgagct gggtccgtca ggcacctg 48 <210> SEQ ID NO 205
<211> LENGTH: 47 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 9C8-H1R1
<400> SEQUENCE: 205 gtagctactg aggtcgattc cagaagctgc
acaggagagg cgcaggg 47 <210> SEQ ID NO 206 <211> LENGTH:
47 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 9C8-H1R2 <400> SEQUENCE: 206
gtagctactg aggtcgattc cagagacagt acaggagagg cgcaggg 47 <210>
SEQ ID NO 207 <211> LENGTH: 53 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 9C8-H2F <400> SEQUENCE: 207 actgatagta gcacatacta
cgcgaactgg gcgaagggcc gcttcaccat cag 53 <210> SEQ ID NO 208
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 9C8-H2R
<400> SEQUENCE: 208 gcgtagtatg tgctactatc agtataaatg
tagctcaccc actccagacc c 51 <210> SEQ ID NO 209 <211>
LENGTH: 53 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 9C8-H3R1 <400>
SEQUENCE: 209 gtgtcgaaag cataatcggt actacctctg gcgcagtaat
acaccgcggt gtc 53 <210> SEQ ID NO 210
<211> LENGTH: 53 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 9C8-H3R2
<400> SEQUENCE: 210 gaccagggtg ccctggcccc agagatccaa
ccgagtgtcg aaagcataat cgg 53 <210> SEQ ID NO 211 <211>
LENGTH: 38 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 13A8-L2F <400>
SEQUENCE: 211 gggcatccac tctgacatct ggagtcccat caaggttc 38
<210> SEQ ID NO 212 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 13A8-L2R <400> SEQUENCE: 212 gactccagat gtcagagtgg
atgccctata gatcag 36 <210> SEQ ID NO 213 <211> LENGTH:
21 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 13A8-H2F <400> SEQUENCE: 213
gcacatggta cgcgaactgg g 21 <210> SEQ ID NO 214 <211>
LENGTH: 27 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 13A8-H2R <400>
SEQUENCE: 214 agttcgcgta ccatgtgcta ctatcag 27 <210> SEQ ID
NO 215 <211> LENGTH: 27 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Oligonucleotide primer
13A8-EcoF <400> SEQUENCE: 215 gggacagaat tcactctcac aatcagc
27 <210> SEQ ID NO 216 <211> LENGTH: 28 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer 13A8-EcoR <400> SEQUENCE: 216
gagagtgaat tctgtcccag atccactg 28 <210> SEQ ID NO 217
<211> LENGTH: 49 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-L1F
<400> SEQUENCE: 217 gccagtgagg acatcgagag ctacctggct
tggtatcagc aaaaaccag 49 <210> SEQ ID NO 218 <211>
LENGTH: 46 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 31A12-L1R <400>
SEQUENCE: 218 agctctcgat gtcctcactg gcctggcaag tgatggtgac tctgtc 46
<210> SEQ ID NO 219 <211> LENGTH: 42 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-L2F <400> SEQUENCE: 219 agtgcatcca ctctgacctc
tggcgtccca tcaaggttca gc 42 <210> SEQ ID NO 220 <211>
LENGTH: 40 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 31A12-L2R <400>
SEQUENCE: 220 agaggtcaga gtggatgcac tatagatcag gagcttaggg 40
<210> SEQ ID NO 221 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-L3F <400> SEQUENCE: 221 gtctcggtgc tgacgatacc
actaccgtct tcggcggagg gaccaaggtg 50 <210> SEQ ID NO 222
<211> LENGTH: 47 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-L3R
<400> SEQUENCE: 222 agtggtatcg tcagcaccga gacagtaata
agttgcaaaa tcttcag 47 <210> SEQ ID NO 223 <211> LENGTH:
49 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-H1F <400> SEQUENCE:
223 ggattcagcc tcagttccta ttggatgacc tgggtccgtc aggcacctg 49
<210> SEQ ID NO 224 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-H1R <400> SEQUENCE: 224 ataggaactg aggctgaatc
cagaggctgt acaggagagg cgcagggac 49 <210> SEQ ID NO 225
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 31A12-H2F
<400> SEQUENCE: 225 agctccacat actatgcatc ttgggcgaaa
ggccgcttca ccatcagccg c 51 <210> SEQ ID NO 226 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 31A12-H2R <400>
SEQUENCE: 226 gatgcatagt atgtggagct ggtagcaata gtgcccaccc
actccaaacc c 51 <210> SEQ ID NO 227 <211> LENGTH: 50
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 31A12-H3R1 <400> SEQUENCE:
227 agagatctaa gtcatagtct gtagtgagtc ctctggcgca gtaatacacc 50
<210> SEQ ID NO 228 <211> LENGTH: 55 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 31A12-HxhoR <400> SEQUENCE: 228 gaccgctcga gacggtgacc
agggtgccct ggccccagag atctaagtca tagtc 55 <210> SEQ ID NO 229
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-L1F <400> SEQUENCE: 229 agagtattta taataacaac
ctcttatcct ggtatcagca aaaaccaggg 50 <210> SEQ ID NO 230
<211> LENGTH: 54 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-L1R
<400> SEQUENCE: 230 ggataagagg ttgttattat aaatactctg
actggactgg caagtgatgg tgac 54 <210> SEQ ID NO 231 <211>
LENGTH: 39 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-L2F <400>
SEQUENCE: 231 gcatccactc tggcatctgg cgtcccatca aggttcagc 39
<210> SEQ ID NO 232 <211> LENGTH: 43 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-L2R <400> SEQUENCE: 232 gccagatgcc agagtggatg
caaaatagat caggagctta ggg 43 <210> SEQ ID NO 233 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-L3F <400>
SEQUENCE: 233 ggcggttatg atgatgatgc tgatactgct ttcggcggag
ggaccaaggt g 51 <210> SEQ ID NO 234 <211> LENGTH: 49
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 45G5-L3R <400> SEQUENCE: 234
gcatcatcat cataaccgcc tagacagtaa taagttgcaa aatcttcag 49
<210> SEQ ID NO 235 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-H1F <400> SEQUENCE: 235 ggattctccc tcagtgtata
tccaataaac tgggtccgtc aggcacctg 49 <210> SEQ ID NO 236
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-H1R
<400> SEQUENCE: 236 gatatacact gagggagaat ccagagactg
tacaggagag gcgcagggac 50 <210> SEQ ID NO 237 <211>
LENGTH: 54 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 45G5-H2F <400>
SEQUENCE: 237 gttgatgaca cagcctactc agcctgggcg aaaggccgct
tcaccatcag ccgc 54 <210> SEQ ID NO 238 <211> LENGTH: 54
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 45G5-H2R <400> SEQUENCE: 238
gagtaggctg tgtcatcaac atcattaata atgcccaccc actccaaacc cttg 54
<210> SEQ ID NO 239 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 45G5-H3R1 <400> SEQUENCE: 239 agcatctcca gcataagcat
aactcaaata acctctggcg cagtaataca cc 52 <210> SEQ ID NO 240
<211> LENGTH: 53 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 45G5-H3R2
<400> SEQUENCE: 240 acggtgacca gggtgccctg gccccaggga
tcgaaagcat ctccagcata agc 53 <210> SEQ ID NO 241 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 22H8-L1F <400>
SEQUENCE: 241 agactgtcta taagaacaac ctcttatcct ggtatcagca
aaaaccaggg 50 <210> SEQ ID NO 242 <211> LENGTH: 50
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 22H8-L1R <400> SEQUENCE: 242
ggttgttctt atagacagtc tgactggact ggcaagtgat ggtgactctg 50
<210> SEQ ID NO 243 <211> LENGTH: 48 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-L2F <400> SEQUENCE: 243 gatctatctg gcatccactc
tggcatctgg cgtcccatca aggttcag 48 <210> SEQ ID NO 244
<211> LENGTH: 40 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-L2R
<400> SEQUENCE: 244 agatgccaga gtggatgcca gatagatcag
gagcttaggg 40 <210> SEQ ID NO 245 <211> LENGTH: 52
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 22H8-L3F <400> SEQUENCE: 245
aggcggttat gatgatgacg ctgatactgc tttcggcgga gggaccaagg tg 52
<210> SEQ ID NO 246 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-L3R <400> SEQUENCE: 246 gcgtcatcat cataaccgcc
tagacagtaa taagttgcaa aatcttcag 49 <210> SEQ ID NO 247
<211> LENGTH: 49 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-H1F
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: n is a, c, g,
or t <400> SEQUENCE: 247 ggattctccc tcagtaccta tacantgaac
tgggtccgtc aggcacctg 49 <210> SEQ ID NO 248 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-H1R <400> SEQUENCE: 248 gtataggtac tgagggagaa
tccagagact gtacaggaga ggcgcaggga c 51 <210> SEQ ID NO 249
<211> LENGTH: 53 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer 22H8-H2F
<400> SEQUENCE: 249 atggtggcac agcctacgcg aactgggcga
aaggccgctt caccatcagc cgc 53 <210> SEQ ID NO 250 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer 22H8-H2R <400>
SEQUENCE: 250 gcgtaggctg tgccaccatc ataactaatg gcgcccaccc
actccaaacc c 51 <210> SEQ ID NO 251 <211> LENGTH: 55
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer 22H8-H3R1 <400> SEQUENCE:
251 gaaagcatcc ccaatataag cataaacata aaaacctctg gcgcagtaat acacc 55
<210> SEQ ID NO 252 <211> LENGTH: 51 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Oligonucleotide
primer 22H8-H3R2 <400> SEQUENCE: 252 ggtgaccagg gtgccctggc
cccagggatc gaaagcatcc ccaatataag c 51 <210> SEQ ID NO 253
<211> LENGTH: 32 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer H82XR
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: n is a, c, g,
or t <400> SEQUENCE: 253 gcaggctgtt ganttgcaga tacagggtgt tc
32 <210> SEQ ID NO 254 <211> LENGTH: 32 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
Oligonucleotide primer H82XF <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (9)..(9) <223>
OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 254
atctgcaant caacagcctg cgtgccgagg ac 32 <210> SEQ ID NO 255
<211> LENGTH: 53 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer DPK8gsR1
<400> SEQUENCE: 255 gccgctaccg ccaccaccag aaccgccacc
gcctttgatt tccaccttgg tcc 53 <210> SEQ ID NO 256 <211>
LENGTH: 56 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Oligonucleotide primer DPK8gsR2 <400>
SEQUENCE: 256 ctgcacctcg gatccgcccc ctccggaacc accgccgccg
ctaccgccac caccag 56 <210> SEQ ID NO 257 <211> LENGTH:
28 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Oligonucleotide primer DP427BamF <400> SEQUENCE:
257 gggcggatcc gaggtgcagc tggtggag 28 <210> SEQ ID NO 258
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Oligonucleotide primer DPK8scfvR
<400> SEQUENCE: 258 accgcctttg atttccacct tggtccctcc gccgaa
36 <210> SEQ ID NO 259 <211> LENGTH: 121 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 13A8 VH AA <400> SEQUENCE: 259 Glu Val Gln Leu Val
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 20 25 30 Asp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40
45 Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp Ala Lys
50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr
Arg Leu Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser
Ser 115 120 <210> SEQ ID NO 260 <211> LENGTH: 363
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 13A8 VH nt <400> SEQUENCE: 260 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag tctctggaat cgacctcagt agctacgaca tgagctgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggctac atttatactg atagtagcac
atggtacgcg 180 aactgggcga agggccgctt caccatcagc cgcgacaact
ccaagaacac cctgtatctg 240 caaatgaaca gcctgcgtgc cgaggacacc
gcggtgtatt actgcgccag aggtagtacc 300 gattatgctt tcgacactcg
gttggatctc tggggccagg gcaccctggt caccgtctcg 360 agc 363 <210>
SEQ ID NO 261 <211> LENGTH: 110 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 13A8
VL AA <400> SEQUENCE: 261 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala
Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70
75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser Asn
Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 <210> SEQ ID NO 262 <211> LENGTH: 330
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 13A8 VL nt <400> SEQUENCE: 262 gacatccagt
tgacccagtc tccatccttt ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtca gagcattagc aatgaattat cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctatagg gcatccactc tgacatctgg
agtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca
caatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt tgataatgtt
300 ttcggcggag ggaccaaggt ggaaatcaaa 330 <210> SEQ ID NO 263
<211> LENGTH: 124 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 28D2 VH AA <400>
SEQUENCE: 263 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu
Ser Leu Ser Lys Asn 20 25 30 Ala Ile Ala Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Tyr Ala Gly Gly
Ala Thr Thr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg
Glu Tyr Ala Gly Asp Ser Tyr Tyr Thr Gly Tyr Thr Gln Leu Asp 100 105
110 Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 264 <211> LENGTH: 372 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 28D2
VH nt <400> SEQUENCE: 264 gaggtgcagc tggtggagtc tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggatt
atccctcagt aagaatgcaa ttgcctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgggcatc atttatgctg gtggtgccac aacctacgcg 180
agctgggcga aaggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg
240 caaatgaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
agaatatgct 300 ggtgatagtt attatactgg atacactcag ttggatctct
ggggccaggg caccctggtc 360 accgtctcga gc 372 <210> SEQ ID NO
265 <211> LENGTH: 112 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 28D2 VL AA
<400> SEQUENCE: 265 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln
Ala Ser Glu Asp Leu Phe Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser
Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu Thr 85
90 95 Pro Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 <210> SEQ ID NO 266 <211> LENGTH: 336
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 28D2 VL nt <400> SEQUENCE: 266 gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtga ggaccttttt agtagtttgg cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg
ggtcccatca 180 aggttcagcg gcagtggatc tgggacagac ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctaggc
ctttactatt atcttactcc tgatcctatt 300 tatgggttcg gcggagggac
caaggtggaa atcaaa 336 <210> SEQ ID NO 267 <211> LENGTH:
117 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 31A12 VH AA <400> SEQUENCE: 267 Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20
25 30 Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp
Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Gly Leu Thr Thr Asp Tyr Asp
Leu Asp Leu Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 <210> SEQ ID NO 268 <211> LENGTH: 350 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 31A12 VH nt <400> SEQUENCE: 268 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag cctctggatt cagcctcagt tcctattgga tgacctgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggcact attgctacca gctccacata
ctatgcatct 180 tgggcgaaag gccgcttcac catcagccgc gacaactcca
agaacaccct gtatctgcaa 240 atgaacagcc tgcgtgccga ggacaccgcg
gtgtattact gcgccagagg actcactaca 300 gactatgact tagatctctg
gggccagggc accctggtca ccgtctcgac 350 <210> SEQ ID NO 269
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 31A12 VL AA <400>
SEQUENCE: 269 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu
Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Thr
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr Thr Thr 85 90 95 Val
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> SEQ ID
NO 270 <211> LENGTH: 321 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 31A12 VL nt
<400> SEQUENCE: 270 gacatccagt tgacccagtc tccatccttc
ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtga
ggacatcgag agctacctgg cttggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagt gcatccactc tgacctctgg cgtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtctcggt gctgacgata ccactaccgt
cttcggcgga 300 gggaccaagg tggaaatcaa a 321 <210> SEQ ID NO
271 <211> LENGTH: 122 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: humanized 22H8 VH AA
<400> SEQUENCE: 271 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val
Ser Gly Phe Ser Leu Ser Thr Tyr 20 25 30 Thr Met Asn Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ala Ile Ser
Tyr Asp Gly Gly Thr Ala Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85
90 95
Arg Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp Ala Phe Asp Pro Trp 100
105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210>
SEQ ID NO 272 <211> LENGTH: 366 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 22H8
VH nt <400> SEQUENCE: 272 gaggtgcagc tggtggagtc tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtacag tctctggatt
ctccctcagt acctatacaa tgaactgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgggcgcc attagttatg atggtggcac agcctacgcg 180
aactgggcga aaggccgctt caccatcagc cgcgacaact ccaagaacac cctgtatctg
240 caactcaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtttttat 300 gtttatgctt atattgggga tgctttcgat ccctggggcc
agggcaccct ggtcaccgtc 360 tcgagc 366 <210> SEQ ID NO 273
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: humanized 22H8 VL AA <400>
SEQUENCE: 273 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln
Thr Val Tyr Lys Asn 20 25 30 Asn Leu Leu Ser Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Leu Ala Ser Thr
Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 85 90 95 Asp
Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
<210> SEQ ID NO 274 <211> LENGTH: 333 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 22H8
VL nt <400> SEQUENCE: 274 gacatccagt tgacccagtc tccatccttc
ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca
gactgtctat aagaacaacc tcttatcctg gtatcagcaa 120 aaaccaggga
aagcccctaa gctcctgatc tatctggcat ccactctggc atctggcgtc 180
ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg
240 cagcctgaag attttgcaac ttattactgt ctaggcggtt atgatgatga
cgctgatact 300 gctttcggcg gagggaccaa ggtggaaatc aaa 333 <210>
SEQ ID NO 275 <211> LENGTH: 122 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 45G5
VH AA <400> SEQUENCE: 275 Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr
Val Ser Gly Phe Ser Leu Ser Val Tyr 20 25 30 Pro Ile Asn Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile
Asn Asp Val Asp Asp Thr Ala Tyr Ser Ala Trp Ala Lys 50 55 60 Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70
75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
Ala 85 90 95 Arg Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp Ala Phe
Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115
120 <210> SEQ ID NO 276 <211> LENGTH: 366 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence:
humanized 45G5 VH nt <400> SEQUENCE: 276 gaggtgcagc
tggtggagtc tggcggtggc ttggtacagc cgggcgggtc cctgcgcctc 60
tcctgtacag tctctggatt ctccctcagt gtatatccaa taaactgggt ccgtcaggca
120 cctggcaagg gtttggagtg ggtgggcatt attaatgatg ttgatgacac
agcctactca 180 gcctgggcga aaggccgctt caccatcagc cgcgacaact
ccaagaacac cctgtatctg 240 caaatgaaca gcctgcgtgc cgaggacacc
gcggtgtatt actgcgccag aggttatttg 300 agttatgctt atgctggaga
tgctttcgat ccctggggcc agggcaccct ggtcaccgtc 360 tcgagc 366
<210> SEQ ID NO 277 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: humanized 45G5
VL AA <400> SEQUENCE: 277 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ser Ser Gln Ser Ile Tyr Asn Asn 20 25 30 Asn Leu Leu Ser Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr
Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70
75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp
Asp 85 90 95 Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys 100 105 110 <210> SEQ ID NO 278 <211> LENGTH:
333 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: humanized 45G5 VL nt <400> SEQUENCE: 278 gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc agtccagtca gagtatttat aataacaacc tcttatcctg gtatcagcaa
120 aaaccaggga aagcccctaa gctcctgatc tattttgcat ccactctggc
atctggcgtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca
ctctcacaat cagcagcctg 240 cagcctgaag attttgcaac ttattactgt
ctaggcggtt atgatgatga tgctgatact 300 gctttcggcg gagggaccaa
ggtggaaatc aaa 333 <210> SEQ ID NO 279 <211> LENGTH:
753 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 13A8 LL scfv Ecoli <400> SEQUENCE: 279 gatattcaat
taactcagag cccatctttc ttatctgcca gtgtgggtga tcgtgttact 60
attacatgtc aagcaagcca atcaattagc aacgaattat cttggtacca acagaaacca
120 ggcaaagcac caaagttact catttatcgc gcgtctacct taacttcagg
cgtcccatct 180 cgtttttccg gcagcggctc cggcactgaa tttactttaa
cgatttcctc tttacaaccc 240 gaagattttg cgacttatta ttgccaacag
ggttacaata gcaacgatgt ggataatgta 300 tttggcggcg gcaccaaggt
tgaaattaaa ggaggcggtg gctccggcgg aggcggctca 360 ggcggcggcg
gtagtggagg aggtggttcc gaagttcaac tggtcgaatc aggtggtggt 420
ttagtccaac cgggcggcag tttacgttta tcttgcaccg tgagtggtat cgacttgtct
480 tcttatgatc tctcctgggt acgtcaggca ccgggaaaag gcttggaatg
ggtaggttat 540 atttatacag attcttcaac ttggtatgca aattgggcta
aagggcgctt cactatttcc 600 cgcgataact ctaaaaatac gctctattta
caattaaact cattacgcgc agaagataca 660 gccgtctact attgcgcacg
gggtagcacc gattatgcat ttgatacgcg tctggatctt 720 tggggtcaag
gcaccttagt aaccgtatct tca 753 <210> SEQ ID NO 280 <211>
LENGTH: 251 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 13A8 LL scfv Ecoli <400> SEQUENCE: 280
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn
Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro
Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu
Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr
Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu
Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser 145 150 155 160 Ser
Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170
175 Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala Asn Trp
180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu 195 200 205 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe
Asp Thr Arg Leu Asp Leu 225 230 235 240 Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser 245 250 <210> SEQ ID NO 281 <211>
LENGTH: 768 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 28D2 H82L scfv Ecoli <400> SEQUENCE: 281
gacatccagt tgacccagtc accatcattc ctgtctgcat ctgtaggaga ccgtgtcacc
60 atcacttgcc aggccagtga ggaccttttt agtagtttgg cctggtatca
gcaaaaacca 120 ggtaaagccc ctaagttact gatctattct gcatcaacgc
tggcatctgg tgtcccatca 180 cgcttcagcg gcagtggatc tgggacagac
ttcactttaa caatcagcag cctgcagccg 240 gaagattttg caacgtatta
ctgtttaggt ctttactatt atcttactcc tgatccgatt 300 tatggtttcg
gcggagggac caaggtggaa atcaaaggtg gcggaggttc tggcggtggt 360
ggcagcggtg ggggtggctc aggaggtggc ggttccgagg tgcagctggt ggagtctgga
420 ggtggcttgg tacagccggg cggttcactg cgcctctcct gtacagtctc
tggattatca 480 ttaagtaaga atgcaattgc ctgggtccgt caggcacctg
gcaagggttt ggagtgggtg 540 ggcatcattt atgctggtgg tgccacaacc
tacgcgagct gggcgaaagg ccgcttcacc 600 atcagccgcg acaactcaaa
gaacaccctg tatctgcaat taaacagcct gcgtgccgag 660 gacaccgcgg
tgtattactg cgcccgtgaa tatgctggtg atagttatta tacgggatac 720
actcagttgg atctctgggg tcagggcacc ctggtcaccg tctcgagc 768
<210> SEQ ID NO 282 <211> LENGTH: 256 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 28D2 H82L scfv
Ecoli <400> SEQUENCE: 282 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ala Ser Glu Asp Leu Phe Ser Ser 20 25 30 Leu Ala Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala
Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70
75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr Leu
Thr 85 90 95 Pro Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val
Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg
Leu Ser Cys Thr Val Ser Gly Leu Ser 145 150 155 160 Leu Ser Lys Asn
Ala Ile Ala Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu
Trp Val Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr Tyr Ala 180 185 190
Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195
200 205 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val 210 215 220 Tyr Tyr Cys Ala Arg Glu Tyr Ala Gly Asp Ser Tyr Tyr
Thr Gly Tyr 225 230 235 240 Thr Gln Leu Asp Leu Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser 245 250 255 <210> SEQ ID NO 283
<211> LENGTH: 732 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 31A12 LL scfv Ecoli <400>
SEQUENCE: 283 gacatccagt tgacccagtc accatcattc ctgtctgcat
ctgtaggtga ccgtgtcacc 60 atcacttgcc aggccagtga ggacattgaa
agttatttgg cctggtatca gcaaaaacca 120 ggtaaagccc ctaagttact
gatctattct gcatccacgc tgacctctgg tgtcccatcg 180 cgcttcagcg
gcagtggctc tgggacagaa tttactttaa caatcagcag cctgcagccg 240
gaagattttg caacgtatta ctgtttaggt gctgatgaca ctaccacggt tttcggcggt
300 gggaccaagg tggaaatcaa aggtggcggt ggttctggcg gtggtggcag
cggtggcggt 360 ggctccggcg gtggcggttc cgaggtgcaa ctggttgagt
ctggcggtgg cttggtacag 420 ccgggcggtt ctctgcgtct ctcctgtaca
gcgtctggct tttcactgtc cagctactgg 480 ctgacctggg ttcgtcaggc
acctggcaag ggtttggagt gggtgggcac gattgcgacc 540 agctctactt
actacgcgag ctgggcgaaa ggccgcttca ccatcagccg cgacaactcc 600
aagaacaccc tgtatctgca attaaacagc ctgcgtgccg aggacaccgc agtgtattac
660 tgcgcccgtg gtctgaccac ggattatgat ttggatctct ggggtcaggg
caccctggtt 720 accgtctctt ca 732 <210> SEQ ID NO 284
<211> LENGTH: 244 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 31A12 LL scfv Ecoli <400>
SEQUENCE: 284 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu
Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Thr
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe
Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr Thr Thr 85 90 95 Val
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105
110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125 Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
Gly Ser 130 135 140 Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu
Ser Ser Tyr Trp 145 150 155 160 Leu Thr Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val Gly 165 170 175 Thr Ile Ala Thr Ser Ser Thr
Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Leu 195 200 205 Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 210 215 220 Leu
Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly Thr Leu Val 225 230
235 240 Thr Val Ser Ser <210> SEQ ID NO 285 <211>
LENGTH: 759 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 22H8 LL scfv Ecoli <400> SEQUENCE: 285
gacatccagt tgacccagtc accatcattc ctgtctgcat ctgtaggtga ccgtgtcacc
60 atcacttgcc agtccagtca gactgtttat aagaataacc tcttgtcctg
gtatcagcaa 120 aaaccaggta aagcccctaa gttactgatc tatttggcat
ccacgctggc ctctggtgtc 180 ccatcgcgct tcagcggcag tggctctggg
acagaattta ctttaacaat cagcagcctg 240 cagccggaag attttgcaac
gtattactgt ttaggcggtt atgatgacga tgctgatact 300 gctttcggcg
gtgggaccaa ggtggaaatc aaaggtggcg gtggttctgg cggtggtggc 360
agcggtggcg gtggctccgg cggtggcggt tccgaggtgc aactggttga gtctggcggt
420 ggcttggtac agccgggcgg ttctctgcgt ctctcctgta cagtctctgg
attctccctc 480 agtacctata ctctcaactg ggttcgtcag gcacctggca
agggtttgga gtgggtgggc 540 gctattagtt atgatggtgg cacagcctac
gcaaactggg cgaaaggccg cttcaccatc 600
agccgcgaca actccaagaa caccctgtat ctgcaattaa acagcctgcg tgccgaggac
660 accgcagtgt attactgcgc ccgtggtttc tacgtgtatg cttatatcgg
agatgctttc 720 gatccgtggg gtcagggcac cctggttacc gtctcctct 759
<210> SEQ ID NO 286 <211> LENGTH: 253 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 22H8 LL scfv
Ecoli <400> SEQUENCE: 286 Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Gln Ser Ser Gln Thr Val Tyr Lys Asn 20 25 30 Asn Leu Leu Ser Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr
Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70
75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp
Asp 85 90 95 Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln 130 135 140 Pro Gly Gly Ser Leu Arg Leu
Ser Cys Thr Val Ser Gly Phe Ser Leu 145 150 155 160 Ser Thr Tyr Thr
Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp
Val Gly Ala Ile Ser Tyr Asp Gly Gly Thr Ala Tyr Ala Asn 180 185 190
Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195
200 205 Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr 210 215 220 Tyr Cys Ala Arg Gly Phe Tyr Val Tyr Ala Tyr Ile Gly
Asp Ala Phe 225 230 235 240 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 245 250 <210> SEQ ID NO 287 <211> LENGTH:
774 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5A LL C H33A bacterial optimized <400>
SEQUENCE: 287 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccagtc cagtcagagt
atttataata acaacctctt atcctggtat 120 cagcaaaaac caggtaaagc
ccctaagtta ctgatctatt ttgcatccac gctggcctct 180 ggtgtcccat
cgcgcttcag cggcagtggc tctgggacag aatttacttt aacaatcagc 240
agcctgcagc cggaagattt tgcaacgtat tactgtttag gcggttatga tgacgatgct
300 gatactgctt tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg
ttctggcggt 360 ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg
aggtgcaact ggttgagtct 420 ggcggtggct tggtacagcc gggcggttct
ctgcgtctct cctgtacagt ctctggattc 480 tccctcagtg tatatgcaat
aaactgggtt cgtcaggcac ctggcaaggg tttggagtgg 540 gtgggcatta
ttaatgatgt tgatgacaca gcctactcag cctgggcgaa aggccgcttc 600
accatcagcc gcgacaactc caagaacacc ctgtatctgc aattaaacag cctgcgtgcc
660 gaggacaccg cagtgtatta ctgcgcccgt ggttatttga gttatgctta
tgctggagat 720 gctttcgatc cgtggggtca gggcaccctg gttaccgtct
cgagcggtat gtga 774 <210> SEQ ID NO 288 <211> LENGTH:
257 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5A LL C H33A bacterial optimized <400>
SEQUENCE: 288 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser
Ser Gln Ser Ile Tyr 20 25 30 Asn Asn Asn Leu Leu Ser Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Phe Ala
Ser Thr Leu Ala Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp
Asp Asp Ala Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105
110 Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly
Gly Leu 130 135 140 Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr
Val Ser Gly Phe 145 150 155 160 Ser Leu Ser Val Tyr Ala Ile Asn Trp
Val Arg Gln Ala Pro Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ile
Ile Asn Asp Val Asp Asp Thr Ala Tyr 180 185 190 Ser Ala Trp Ala Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val
Tyr Tyr Cys Ala Arg Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly Asp 225 230
235 240 Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
Gly 245 250 255 Met <210> SEQ ID NO 289 <211> LENGTH:
774 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 45G5\L\C\mp7 bacterial optimized <400> SEQUENCE:
289 atggcggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt
aggtgaccgt 60 gtcaccatca cttgccagtc cagtcagagt atttataata
acaacctctt gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta
ctgatctatt ttgcatccac gctggcctct 180 ggtgtcccat cgcgcttcag
cggcagtggc tctgggacag aatttacttt aacaatcagc 240 agcctgcagc
cggaagattt tgcaacgtat tactgtttag gcggttatga tgacgatgct 300
gatactgctt tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt
360 ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact
ggttgagtct 420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct
cctgtacagt ctctggattc 480 tccctcagtg tatatccaat aaactgggtt
cgtcaggcac ctggcaaggg tttggagtgg 540 gtgggcatta ttaatgatgt
tgatgacaca gcctactcag cctgggcgaa aggccgcttc 600 accatcagcc
gcgacaactc caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660
gaggacaccg cagtgtatta ctgcgcccgt ggttatttga gttatgctta tgctggagat
720 gctttcgatc cgtggggtca gggcaccctg gttaccgtct cgagcggtat gtga 774
<210> SEQ ID NO 290 <211> LENGTH: 257 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 45G5\L\C\mp7
bacterial optimized <400> SEQUENCE: 290 Met Ala Asp Ile Gln
Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp
Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Ile Tyr 20 25 30 Asn
Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40
45 Lys Leu Leu Ile Tyr Phe Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr Ala Phe Gly Gly
Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140 Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145 150 155 160 Ser
Leu Ser Val Tyr Pro Ile Asn Trp Val Arg Gln Ala Pro Gly Lys 165 170
175 Gly Leu Glu Trp Val Gly Ile Ile Asn Asp Val Asp Asp Thr Ala Tyr
180 185 190 Ser Ala Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys 195 200 205
Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 210
215 220 Val Tyr Tyr Cys Ala Arg Gly Tyr Leu Ser Tyr Ala Tyr Ala Gly
Asp 225 230 235 240 Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly 245 250 255 Met <210> SEQ ID NO 291
<211> LENGTH: 768 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 13A8 LL-C scFv No His tag
nucleotide seq <400> SEQUENCE: 291 atggccgata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcggaggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcag gtatgtaa 768 <210> SEQ ID NO 292
<211> LENGTH: 255 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 13A8 LL-C scFv No His tag amino
acid seq <400> SEQUENCE: 292 Met Ala Asp Ile Gln Leu Thr Gln
Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr
Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile
Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65
70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr
Asn Ser 85 90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu
Arg Leu Ser Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser Ser
Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu
Glu Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180 185
190 Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
195 200 205 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe
Asp Thr Arg Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly Met 245 250 255 <210> SEQ ID NO 293
<211> LENGTH: 762 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 13A8 LL-N scFv No His tag
nucleotide seq <400> SEQUENCE: 293 atggaggata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcggaggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcat aa 762 <210> SEQ ID NO 294 <211>
LENGTH: 253 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 13A8 LL-N scFv No His tag amino acid seq
<400> SEQUENCE: 294 Met Glu Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Arg
Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn Ser 85
90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser
Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser Ser Tyr Asp Leu
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Val
Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180 185 190 Asn Trp
Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205
Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210
215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg
Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser 245 250 <210> SEQ ID NO 295 <211> LENGTH: 747
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 31A12 LL-C scFv no his tag nucleotide seq <400>
SEQUENCE: 295 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccaggc cagtgaggac
attgaaagtt atttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat ccacgctgac ctctggtgtc 180 ccatcgcgct
tcagcggcag tggctctggg acagaattta ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtgctg atgacactac cacggttttc
300 ggcggtggga ccaaggtgga aatcaaaggt ggcggtggtt ctggcggtgg
tggcagcggt 360 ggcggtggct ccggcggtgg cggttccgag gtgcaactgg
ttgagtctgg cggtggcttg 420 gtacagccgg gcggttctct gcgtctctcc
tgtacagcgt ctggcttttc actgtccagc 480 tactggctga cctgggttcg
tcaggcacct ggcaagggtt tggagtgggt gggcacgatt 540 gcgaccagct
ctacttacta cgcgagctgg gcgaaaggcc gcttcaccat cagccgcgac 600
aactccaaga acaccctgta tctgcaatta aacagcctgc gtgccgagga caccgcagtg
660 tattactgcg cccgtggtct gaccacggat tatgatttgg atctctgggg
tcagggcacc 720 ctggttaccg tctcgagcgg tatgtga 747 <210> SEQ ID
NO 296 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 23 31A12 LL-C scFv no
his tag amino acid seq <400> SEQUENCE: 296 Met Ala Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35
40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg
Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
Ser Ser Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
Gly Ala Asp Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu
Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser 145 150 155 160
Tyr Trp Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165
170 175 Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala
Lys 180 185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr Leu 195 200 205 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys Ala 210 215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu
Asp Leu Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser
Gly Met 245 <210> SEQ ID NO 297 <211> LENGTH: 741
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 23 31A12 LL-N scFv no histag nucleotide seq <400>
SEQUENCE: 297 atggaggaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggtgaccgt 60 gtcaccatca cttgccaggc cagtgaggac
attgaaagtt atttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat ccacgctgac ctctggtgtc 180 ccatcgcgct
tcagcggcag tggctctggg acagaattta ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtgctg atgacactac cacggttttc
300 ggcggtggga ccaaggtgga aatcaaaggt ggcggtggtt ctggcggtgg
tggcagcggt 360 ggcggtggct ccggcggtgg cggttccgag gtgcaactgg
ttgagtctgg cggtggcttg 420 gtacagccgg gcggttctct gcgtctctcc
tgtacagcgt ctggcttttc actgtccagc 480 tactggctga cctgggttcg
tcaggcacct ggcaagggtt tggagtgggt gggcacgatt 540 gcgaccagct
ctacttacta cgcgagctgg gcgaaaggcc gcttcaccat cagccgcgac 600
aactccaaga acaccctgta tctgcaatta aacagcctgc gtgccgagga caccgcagtg
660 tattactgcg cccgtggtct gaccacggat tatgatttgg atctctgggg
tcagggcacc 720 ctggttaccg tctcttcatg a 741 <210> SEQ ID NO
298 <211> LENGTH: 246 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 23 31A12 LL-N scFv no histag
amino acid seq <400> SEQUENCE: 298 Met Glu Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala
Asp Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu
Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr Trp
Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175
Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 180
185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
Leu 195 200 205 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala 210 215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu
Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser 245
<210> SEQ ID NO 299 <211> LENGTH: 768 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Nterm bact constr ntide seq <400> SEQUENCE: 299
atggaggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccagtc cagtcagact gtttataaga ataacctctt
gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta ctgatctatt
tggcatccac gctggcctct 180 ggtgtcccat cgcgcttcag cggcagtggc
tctgggacag aatttacttt aacaatcagc 240 agcctgcagc cggaagattt
tgcaacgtat tactgtttag gcggttatga tgacgatgct 300 gatactgctt
tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt 360
ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact ggttgagtct
420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct cctgtacagt
ctctggattc 480 tccctcagta cctatactct caactgggtt cgtcaggcac
ctggcaaggg tttggagtgg 540 gtgggcgcta ttagttatga tggtggcaca
gcctacgcaa actgggcgaa aggccgcttc 600 accatcagcc gcgacaactc
caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660 gaggacaccg
cagtgtatta ctgcgcccgt ggtttctacg tgtatgctta tatcggagat 720
gctttcgatc cgtggggtca gggcaccctg gttaccgtct cctcttaa 768
<210> SEQ ID NO 300 <211> LENGTH: 255 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Nterm bact constr aa seq <400> SEQUENCE: 300 Met
Glu Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10
15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Val Tyr
20 25 30 Lys Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Ala Ser
Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala
Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr
Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145
150 155 160 Ser Leu Ser Thr Tyr Thr Leu Asn Trp Val Arg Gln Ala Pro
Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ala Ile Ser Tyr Asp Gly
Gly Thr Ala Tyr 180 185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn
Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg
Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp 225 230 235 240 Ala Phe Asp
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 245 250 255
<210> SEQ ID NO 301 <211> LENGTH: 777 <212> TYPE:
DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Cterm bact constr ntide seq <400> SEQUENCE: 301
atggccgaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccagtc cagtcagact gtttataaga ataacctctt
gtcctggtat 120 cagcaaaaac caggtaaagc ccctaagtta ctgatctatt
tggcatccac gctggcctct 180 ggtgtcccat cgcgcttcag cggcagtggc
tctgggacag aatttacttt aacaatcagc 240 agcctgcagc cggaagattt
tgcaacgtat tactgtttag gcggttatga tgacgatgct 300 gatactgctt
tcggcggtgg gaccaaggtg gaaatcaaag gtggcggtgg ttctggcggt 360
ggtggcagcg gtggcggtgg ctccggcggt ggcggttccg aggtgcaact ggttgagtct
420 ggcggtggct tggtacagcc gggcggttct ctgcgtctct cctgtacagt
ctctggattc 480 tccctcagta cctatactct gaactgggtt cgtcaggcac
ctggcaaggg tttggagtgg 540 gtgggcgcta ttagttatga tggtggcaca
gcctacgcaa actgggcgaa aggccgcttc 600 accatcagcc gcgacaactc
caagaacacc ctgtatctgc aattaaacag cctgcgtgcc 660 gaggacaccg
cagtgtatta ctgcgcccgt ggtttctacg tgtatgctta tatcggagat 720
gctttcgatc cgtggggtca gggcaccctg gttaccgtct cgagcggtat gtgataa 777
<210> SEQ ID NO 302 <211> LENGTH: 257 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 22H8
H34L/H82L Cterm bact constr aa seq <400> SEQUENCE: 302 Met
Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10
15 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Val Tyr
20 25 30 Lys Asn Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Ala Ser
Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala
Thr Tyr Tyr Cys Leu Gly Gly Tyr 85 90 95 Asp Asp Asp Ala Asp Thr
Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105 110 Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe 145
150 155 160 Ser Leu Ser Thr Tyr Thr Leu Asn Trp Val Arg Gln Ala Pro
Gly Lys 165 170 175 Gly Leu Glu Trp Val Gly Ala Ile Ser Tyr Asp Gly
Gly Thr Ala Tyr 180 185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn
Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg
Gly Phe Tyr Val Tyr Ala Tyr Ile Gly Asp 225 230 235 240 Ala Phe Asp
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 245 250 255 Met
<210> SEQ ID NO 303 <211> LENGTH: 738 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 23 31A12
LL-Linker scFv no histag ntide seq <400> SEQUENCE: 303
atggcggaca tccagttgac ccagtcacca tcattcctgt ctgcatctgt aggtgaccgt
60 gtcaccatca cttgccaggc cagtgaggac attgaaagtt atttggcctg
gtatcagcaa 120 aaaccaggta aagcccctaa gttactgatc tattctgcat
ccacgctgac ctctggtgtc 180 ccatcgcgct tcagcggcag tggctctggg
acagaattta ctttaacaat cagcagcctg 240 cagccggaag attttgcaac
gtattactgt ttaggtgctg atgacactac cacggttttc 300 ggcggtggga
ccaaggtgga aatcaaaggt ggcggtggtt ctggcatggg tggcagcggt 360
ggcggtggct ccggcggtgg cggttccgag gtgcaactgg ttgagtctgg cggtggcttg
420 gtacagccgg gcggttctct gcgtctctcc tgtacagcgt ctggcttttc
actgtccagc 480 tactggctga cctgggttcg tcaggcacct ggcaagggtt
tggagtgggt gggcacgatt 540 gcgaccagct ctacttacta cgcgagctgg
gcgaaaggcc gcttcaccat cagccgcgac 600 aactccaaga acaccctgta
tctgcaatta aacagcctgc gtgccgagga caccgcagtg 660 tattactgcg
cccgtggtct gaccacggat tatgatttgg atctctgggg tcagggcacc 720
ctggttaccg tctcgagc 738 <210> SEQ ID NO 304 <211>
LENGTH: 246 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 23 31A12 LL-Linker scFv no his tag aa seq
<400> SEQUENCE: 304 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser
Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr 85
90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly
Gly 100 105 110 Gly Ser Gly Met Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Thr Ala
Ser Gly Phe Ser Leu Ser Ser 145 150 155 160 Tyr Trp Leu Thr Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Gly Thr Ile
Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 180 185 190 Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210
215 220 Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly
Thr 225 230 235 240 Leu Val Thr Val Ser Ser 245 <210> SEQ ID
NO 305 <211> LENGTH: 762 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 6 13A8 LL-Linker scFv No His
tag ntide seq <400> SEQUENCE: 305 atggccgata ttcaattaac
tcagagccca tctttcttat ctgccagtgt gggtgatcgt 60 gttactatta
catgtcaagc aagccaatca attagcaacg aattatcttg gtaccaacag 120
aaaccaggca aagcaccaaa gttactcatt tatcgcgcgt ctaccttaac ttcaggcgtc
180 ccatctcgtt tttccggcag cggctccggc actgaattta ctttaacgat
ttcctcttta 240 caacccgaag attttgcgac ttattattgc caacagggtt
acaatagcaa cgatgtggat 300 aatgtatttg gcggcggcac caaggttgaa
attaaaggag gcggtggctc cggcatgggc 360 ggctcaggcg gcggcggtag
tggaggaggt ggttccgaag ttcaactggt cgaatcaggt 420 ggtggtttag
tccaaccggg cggcagttta cgtttatctt gcaccgtgag tggtatcgac 480
ttgtcttctt atgatctctc ctgggtacgt caggcaccgg gaaaaggctt ggaatgggta
540 ggttatattt atacagattc ttcaacttgg tatgcaaatt gggctaaagg
gcgcttcact 600 atttcccgcg ataactctaa aaatacgctc tatttacaat
taaactcatt acgcgcagaa 660 gatacagccg tctactattg cgcacggggt
agcaccgatt atgcatttga tacgcgtctg 720 gatctttggg gtcaaggcac
cttagtaacc gtatcttcag gt 762 <210> SEQ ID NO 306 <211>
LENGTH: 254 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 13A8 LL-Linker scFv No His tag aa seq
<400> SEQUENCE: 306 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
Tyr Asn Ser 85 90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Met Gly Gly
Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser
Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp 145 150 155 160 Leu Ser
Ser Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175
Leu Glu Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr Ala 180
185 190 Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn 195 200 205 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr Ala
Phe Asp Thr Arg Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Gly 245 250 <210> SEQ ID NO 307
<211> LENGTH: 819 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 28D2 LL-C-met scFv 6His
nucleotide sequence <400> SEQUENCE: 307 atggcacatc accatcacca
tcatccaccg ccacctgcgg ccgcagacat ccagttgacc 60 cagtcaccat
cattcctgtc tgcatctgta ggagaccgtg tcaccatcac ttgccaggcc 120
agtgaggacc tttttagtag tttggcctgg tatcagcaaa aaccaggtaa agcccctaag
180 ttactgatct attctgcatc aacgctggca tctggtgtcc catcacgctt
cagcggcagt 240 ggatctggga cagacttcac tttaacaatc agcagcctgc
agccggaaga ttttgcaacg 300 tattactgtt taggtcttta ctattatctt
actcctgatc cgatttatgg tttcggcgga 360 gggaccaagg tggaaatcaa
aggtggcgga ggttctggcg gtggtggcag cggtgggggt 420 ggctcaggag
gtggcggttc cgaggtgcag ctggtggagt ctggaggtgg cttggtacag 480
ccgggcggtt cactgcgcct ctcctgtaca gtctctggat tatcattaag taagaatgca
540 attgcctggg tccgtcaggc acctggcaag ggtttggagt gggtgggcat
catttatgct 600 ggtggtgcca caacctacgc gagctgggcg aaaggccgct
tcaccatcag ccgcgacaac 660 tcaaagaaca ccctgtatct gcaattaaac
agcctgcgtg ccgaggacac cgcggtgtat 720 tactgcgccc gtgaatatgc
tggtgatagt tattatacgg gatacactca gttggatctc 780 tggggtcagg
gcaccctggt caccgtctcg agcggtatg 819 <210> SEQ ID NO 308
<211> LENGTH: 273 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 6 28D2 LL-C-met scFv 6His amino
acid sequence <400> SEQUENCE: 308 Met Ala His His His His His
His Pro Pro Pro Pro Ala Ala Ala Asp 1 5 10 15 Ile Gln Leu Thr Gln
Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp 20 25 30 Arg Val Thr
Ile Thr Cys Gln Ala Ser Glu Asp Leu Phe Ser Ser Leu 35 40 45 Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 50 55
60 Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
65 70 75 80 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu 85 90 95 Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr
Tyr Leu Thr Pro 100 105 110 Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 130 135 140 Gly Gly Ser Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln 145 150 155 160 Pro Gly Gly
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Ser Leu 165 170 175 Ser
Lys Asn Ala Ile Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 180 185
190 Glu Trp Val Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr Tyr Ala Ser
195 200 205 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr 210 215 220 Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr 225 230 235 240 Tyr Cys Ala Arg Glu Tyr Ala Gly Asp
Ser Tyr Tyr Thr Gly Tyr Thr 245 250 255 Gln Leu Asp Leu Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ser Gly 260 265 270 Met <210> SEQ
ID NO 309 <211> LENGTH: 810 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 6 28D2 LL-N-met scFv 6His
nucleotide sequence <400> SEQUENCE: 309 atggaagaca tccagttgac
ccagtcacca tcattcctgt ctgcatctgt aggagaccgt 60 gtcaccatca
cttgccaggc cagtgaggac ctttttagta gtttggcctg gtatcagcaa 120
aaaccaggta aagcccctaa gttactgatc tattctgcat caacgctggc atctggtgtc
180 ccatcacgct tcagcggcag tggatctggg acagacttca ctttaacaat
cagcagcctg 240 cagccggaag attttgcaac gtattactgt ttaggtcttt
actattatct tactcctgat 300 ccgatttatg gtttcggcgg agggaccaag
gtggaaatca aaggtggcgg aggttctggc 360 ggtggtggca gcggtggggg
tggctcagga ggtggcggtt ccgaggtgca gctggtggag 420 tctggaggtg
gcttggtaca gccgggcggt tcactgcgcc tctcctgtac agtctctgga 480
ttatcattaa gtaagaatgc aattgcctgg gtccgtcagg cacctggcaa gggtttggag
540 tgggtgggca tcatttatgc tggtggtgcc acaacctacg cgagctgggc
gaaaggccgc 600 ttcaccatca gccgcgacaa ctcaaagaac accctgtatc
tgcaattaaa cagcctgcgt 660 gccgaggaca ccgcggtgta ttactgcgcc
cgtgaatatg ctggtgatag ttattatacg 720 ggatacactc agttggatct
ctggggtcag ggcaccctgg tcaccgtctc gagcggtcca 780 ccgcctccac
cgcaccatca ccatcatcac 810 <210> SEQ ID NO 310 <211>
LENGTH: 270 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 6 28D2 LL-N-met scFv 6His amino acid sequence
<400> SEQUENCE: 310 Met Glu Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Glu Asp Leu Phe 20 25 30 Ser Ser Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser
Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Tyr Tyr 85
90 95 Leu Thr Pro Asp Pro Ile Tyr Gly Phe Gly Gly Gly Thr Lys Val
Glu 100 105 110 Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val
Glu Ser Gly Gly Gly 130 135 140 Leu Val Gln Pro Gly Gly Ser Leu Arg
Leu Ser Cys Thr Val Ser Gly 145 150 155 160 Leu Ser Leu Ser Lys Asn
Ala Ile Ala Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu
Trp Val Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr 180 185 190 Tyr Ala
Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 195 200 205
Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr 210
215 220 Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Ala Gly Asp Ser Tyr Tyr
Thr 225 230 235 240 Gly Tyr Thr Gln Leu Asp Leu Trp Gly Gln Gly Thr
Leu Val Thr Val 245 250 255 Ser Ser Gly Pro Pro Pro Pro Pro His His
His His His His 260 265 270 <210> SEQ ID NO 311 <211>
LENGTH: 810
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 6 28D2 LL-Linker scFv 6His ntide seq <400>
SEQUENCE: 311 atggcagaca tccagttgac ccagtcacca tcattcctgt
ctgcatctgt aggagaccgt 60 gtcaccatca cttgccaggc cagtgaggac
ctttttagta gtttggcctg gtatcagcaa 120 aaaccaggta aagcccctaa
gttactgatc tattctgcat caacgctggc atctggtgtc 180 ccatcacgct
tcagcggcag tggatctggg acagacttca ctttaacaat cagcagcctg 240
cagccggaag attttgcaac gtattactgt ttaggtcttt actattatct tactcctgat
300 ccgatttatg gtttcggcgg agggaccaag gtggaaatca aaggtggcgg
aggttctggc 360 atgggtggca gcggtggggg tggctcagga ggtggcggtt
ccgaggtgca gctggtggag 420 tctggaggtg gcttggtaca gccgggcggt
tcactgcgcc tctcctgtac agtctctgga 480 ttatcattaa gtaagaatgc
aattgcctgg gtccgtcagg cacctggcaa gggtttggag 540 tgggtgggca
tcatttatgc tggtggtgcc acaacctacg cgagctgggc gaaaggccgc 600
ttcaccatca gccgcgacaa ctcaaagaac accctgtatc tgcaattaaa cagcctgcgt
660 gccgaggaca ccgcggtgta ttactgcgcc cgtgaatatg ctggtgatag
ttattatacg 720 ggatacactc agttggatct ctggggtcag ggcaccctgg
tcaccgtctc gagcggtcca 780 ccgcctccac cgcaccatca ccatcatcac 810
<210> SEQ ID NO 312 <211> LENGTH: 270 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 6 28D2 LL-Linker
scFv 6His aa seq <400> SEQUENCE: 312 Met Ala Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Leu Phe 20 25 30 Ser Ser
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Leu
Tyr Tyr Tyr 85 90 95 Leu Thr Pro Asp Pro Ile Tyr Gly Phe Gly Gly
Gly Thr Lys Val Glu 100 105 110 Ile Lys Gly Gly Gly Gly Ser Gly Met
Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Glu
Val Gln Leu Val Glu Ser Gly Gly Gly 130 135 140 Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly 145 150 155 160 Leu Ser
Leu Ser Lys Asn Ala Ile Ala Trp Val Arg Gln Ala Pro Gly 165 170 175
Lys Gly Leu Glu Trp Val Gly Ile Ile Tyr Ala Gly Gly Ala Thr Thr 180
185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser 195 200 205 Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala
Glu Asp Thr 210 215 220 Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Ala Gly
Asp Ser Tyr Tyr Thr 225 230 235 240 Gly Tyr Thr Gln Leu Asp Leu Trp
Gly Gln Gly Thr Leu Val Thr Val 245 250 255 Ser Ser Gly Pro Pro Pro
Pro Pro His His His His His His 260 265 270 <210> SEQ ID NO
313 <211> LENGTH: 837 <212> TYPE: DNA <213>
ORGANISM: Oryctolagus cuniculus <400> SEQUENCE: 313
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc
60 tatgatatga cccagactcc agcctctgtg gaggtagcta tgggaggcac
agtcaccatc 120 aagtgccagg ccagtcagag cattagcaat gaattatcct
ggtatcagca gaaaccaggg 180 cagcctccca agctcctgat ctacaggaca
tccactctgg catctggggt ctcatcgcgg 240 ttcaaaggca gtggatctgg
gacagagtac actctcacca tcagcggcgt ggagtgtgcc 300 gatgctgcca
cttactactg tcaacagggt tataatagta atgatgttga taatgttttc 360
ggcggaggga ccaaggtggt ggtcgtcggc ggtggcggtt ctggtggtgg cggtagcggc
420 ggcggtggtt ccggaggagg cggatcccag tcggtggagg agtccggggg
tcgcctggtc 480 acgcctggga cacccctgac actcacctgc acagtctctg
gaatcgacct cagtagctac 540 gacatgagct gggtccgcca ggctccaggg
aaggggctgg agtggatcgg atacatttat 600 actgatagta gcacatacta
cgcgaactgg gcgaaaggcc gattcaccat ctccaaaacc 660 tcgaccacgg
tggatctgaa aatgaccagt ctgacaaccg aggacacggc cacctatttc 720
tgtgccaaag gtagtaccga ttatgctttc gacactcggt tggatctctg gggcccaggc
780 accctggtca ccgtctcgag tggtccacct cctccacctc accatcacca tcatcac
837 <210> SEQ ID NO 314 <211> LENGTH: 279 <212>
TYPE: PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 314 Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu
Leu Leu Trp 1 5 10 15 Leu Pro Gly Ala Tyr Asp Met Thr Gln Thr Pro
Ala Ser Val Glu Val 20 25 30 Ala Met Gly Gly Thr Val Thr Ile Lys
Cys Gln Ala Ser Gln Ser Ile 35 40 45 Ser Asn Glu Leu Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys 50 55 60 Leu Leu Ile Tyr Arg
Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg 65 70 75 80 Phe Lys Gly
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly 85 90 95 Val
Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Asn 100 105
110 Ser Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Val Val
115 120 125 Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 130 135 140 Gly Gly Gly Gly Ser Gln Ser Val Glu Glu Ser Gly
Gly Arg Leu Val 145 150 155 160 Thr Pro Gly Thr Pro Leu Thr Leu Thr
Cys Thr Val Ser Gly Ile Asp 165 170 175 Leu Ser Ser Tyr Asp Met Ser
Trp Val Arg Gln Ala Pro Gly Lys Gly 180 185 190 Leu Glu Trp Ile Gly
Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala 195 200 205 Asn Trp Ala
Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val 210 215 220 Asp
Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe 225 230
235 240 Cys Ala Lys Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp
Leu 245 250 255 Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Pro
Pro Pro Pro 260 265 270 Pro His His His His His His 275 <210>
SEQ ID NO 315 <211> LENGTH: 789 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 9C8v6-LL scFV
nuc <400> SEQUENCE: 315 gacatccagc tcacccagtc tccatcctct
gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca
gagcattagc aatgaattat cctggtatca gcaaaaacca 120 gggaaagccc
ctaagctcct gatctatagg acatccactc tggcatctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagac ttcactctca caatcagcag cctgcagcct
240 gaagattttg caacttatta ctgtcaacag ggttataata gtaatgatgt
tgataatgtt 300 ttcggcggag ggaccaaggt ggaaatcaaa ggcggtggcg
gttctggtgg tggcggtagc 360 ggcggcggtg gttccggagg gggcggatcc
gaggtgcagc tggtggagtc tggcggtggc 420 ttggtacagc cgggcgggtc
cctgcgcctc tcctgtacag tctctggaat cgacctcagt 480 agctacgacc
tcagctgggt ccgtcaggca cctggcaagg gtttggagtg ggtgggctac 540
atttatactg atagtagcac atactacgcg aactgggcga agggccgctt caccatcagc
600 cgcgacaact ccaagaacac cctgtatctg caactcaaca gcctgcgtgc
cgaggacacc 660 gcggtgtatt actgcgccag aggtagtacc gattatgctt
tcgacactcg gttggatctc 720 tggggccagg gcaccctggt caccgtctcg
agcggtccac ctcctccacc tcaccatcac 780 catcatcac 789 <210> SEQ
ID NO 316 <211> LENGTH: 263 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8v6-LL scFV AA <400>
SEQUENCE: 316 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly
Lys Ala Pro Lys Leu Leu Ile
35 40 45 Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
Gly Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly
Thr Lys Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser 145 150 155
160 Ser Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
165 170 175 Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala
Asn Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu 195 200 205 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Gly Ser Thr Asp Tyr
Ala Phe Asp Thr Arg Leu Asp Leu 225 230 235 240 Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Pro Pro Pro Pro 245 250 255 Pro His His
His His His His 260 <210> SEQ ID NO 317 <211> LENGTH:
263 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8v3-1 scFV AA <400> SEQUENCE: 317 Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35
40 45 Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser
Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser 145 150 155 160
Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165
170 175 Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn
Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Gly Ser Thr Asp Tyr Ala
Phe Asp Thr Arg Leu Asp Leu 225 230 235 240 Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Gly Pro Pro Pro Pro 245 250 255 Pro His His His
His His His 260 <210> SEQ ID NO 318 <211> LENGTH: 789
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8v3-1 scFV nuc <400> SEQUENCE: 318 gacatccaga
tgacccagtc tccatcctct gtgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtca gagcattagc aatgaattat cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctatagg acatccactc tggcatctgg
ggtcccatca 180 aggttcagcg gcagtggatc tgggacagac ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag
ggttataata gtaatgatgt tgataatgtt 300 ttcggcggag ggaccaaggt
ggaaatcaaa ggcggtggcg gttctggtgg tggcggtagc 360 ggcggcggtg
gttccggagg gggcggatcc gaggtgcagc tggtggagtc tggcggtggc 420
ttggtacagc cgggcgggtc cctgcgcctc tcctgtacag tctctggaat cgacctcagt
480 agctacgaca tgagctgggt ccgtcaggca cctggcaagg gtttggagtg
ggtgggctac 540 atttatactg atagtagcac atactacgcg aactgggcga
agggccgctt caccatcagc 600 cgcgacaact ccaagaacac cctgtatctg
caaatgaaca gcctgcgtgc cgaggacacc 660 gcggtgtatt actgcgccag
aggtagtacc gattatgctt tcgacactcg gttggatctc 720 tggggccagg
gcaccctggt caccgtctcg agcggtccac ctcctccacc tcaccatcac 780
catcatcac 789 <210> SEQ ID NO 319 <211> LENGTH: 789
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8v3-2 scFV nuc <400> SEQUENCE: 319 gacatccaga
tgacccagtc tccatcctct gtgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc aggccagtca gagcattagc aatgaattat cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctatagg acatccactc tggcatctgg
ggtcccatca 180 aggttcagcg gcagtggatc tgggacagac ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag
ggttataata gtaatgatgt tgataatgtt 300 ttcggcggag ggaccaaggt
ggaaatcaaa ggcggtggcg gttctggtgg tggcggtagc 360 ggcggcggtg
gttccggagg gggcggatcc gaggtgcagc tggtggagtc tggcggtggc 420
ttggtacagc cgggcgggtc cctgcgcctc tcctgtgcag cttctggaat cgacctcagt
480 agctacgaca tgagctgggt ccgtcaggca cctggcaagg gtttggagtg
ggtgggctac 540 atttatactg atagtagcac atactacgcg aactgggcga
agggccgctt caccatcagc 600 cgcgacaact ccaagaacac cctgtatctg
caaatgaaca gcctgcgtgc cgaggacacc 660 gcggtgtatt actgcgccag
aggtagtacc gattatgctt tcgacactcg gttggatctc 720 tggggccagg
gcaccctggt caccgtctcg agcggtccac ctcctccacc tcaccatcac 780
catcatcac 789 <210> SEQ ID NO 320 <211> LENGTH: 263
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8v3-2 scFV AA <400> SEQUENCE: 320 Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Glu 20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35
40 45 Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Ser 145 150 155 160
Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165
170 175 Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Tyr Tyr Ala Asn
Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Gly Ser Thr Asp Tyr Ala
Phe Asp Thr Arg Leu Asp Leu 225 230 235 240 Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Gly Pro Pro Pro Pro 245 250 255 Pro His His His
His His His 260 <210> SEQ ID NO 321 <211> LENGTH: 330
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: 9C8-vK-humAb 1&2 nuc <400> SEQUENCE: 321
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc
60 atcacttgcc aggccagtca gagcattagc aatgaattat cctggtatca
gcaaaaacca 120 gggaaagccc ctaagctcct gatctatagg acatccactc
tggcatctgg agtcccatca 180 aggttcagcg gcagtggatc tgggacagaa
ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta
ctgtcaacag ggttataata gtaatgatgt tgataatgtt 300 ttcggcggag
ggaccaaggt ggaaatcaaa 330 <210> SEQ ID NO 322 <211>
LENGTH: 110 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: 9C8-vK-huMab 1&2 AA <400> SEQUENCE:
322 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser
Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val
Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr
Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr
Tyr Cys Gln Gln Gly Tyr Asn Ser Asn Asp 85 90 95 Val Asp Asn Val
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ
ID NO 323 <211> LENGTH: 363 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8-vH humAbv1- nuc
<400> SEQUENCE: 323 gaggtgcagc tggtggagac tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtgcag cttctggaat
cgacctcagt agctacgaca tgagctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgagctac atttatactg atagtagcac atactacgcg 180
aactgggcga agggccgctt caccatcagc cgcgacaatt ccaagaacac cctgtatctg
240 caaatgaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtagtacc 300 gattatgctt tcgacactcg gttggatctc tggggccagg
gcaccctggt caccgtctcg 360 agt 363 <210> SEQ ID NO 324
<211> LENGTH: 121 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 9C8-vH humAbv1 AA <400>
SEQUENCE: 324 Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile
Asp Leu Ser Ser Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Tyr Thr Asp Ser
Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg
Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly 100 105
110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID
NO 325 <211> LENGTH: 363 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 9C8-vH humAbv2 nuc
<400> SEQUENCE: 325 gaggtgcagc tggtggagac tggcggtggc
ttggtacagc cgggcgggtc cctgcgcctc 60 tcctgtactg tctctggaat
cgacctcagt agctacgaca tgagctgggt ccgtcaggca 120 cctggcaagg
gtttggagtg ggtgagctac atttatactg atagtagcac atactacgcg 180
aactgggcga agggccgctt caccatcagc cgcgacaatt ccaagaacac cctgtatctg
240 caaatgaaca gcctgcgtgc cgaggacacc gcggtgtatt actgcgccag
aggtagtacc 300 gattatgctt tcgacactcg gttggatctc tggggccagg
gcaccctggt caccgtctcg 360 agt 363 <210> SEQ ID NO 326
<211> LENGTH: 121 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 9C8-vH humAbv2 AA <400>
SEQUENCE: 326 Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile
Asp Leu Ser Ser Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Tyr Thr Asp Ser
Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg
Gly Ser Thr Asp Tyr Ala Phe Asp Thr Arg Leu Asp Leu Trp Gly 100 105
110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID
NO 327 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Linker, 4 repeats
<400> SEQUENCE: 327 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20 <210>
SEQ ID NO 328 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Linker, 3
repeats <400> SEQUENCE: 328 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 329
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Linker, 5 repeats <400>
SEQUENCE: 329 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25
<210> SEQ ID NO 330 <211> LENGTH: 18 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Linker, non
integer repeat <400> SEQUENCE: 330 Gly Gly Gly Gly Ser Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1 5 10 15 Gly Ser
<210> SEQ ID NO 331 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: 31A12 F12S
mutation <400> SEQUENCE: 331 Met Ala Asp Ile Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr
Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile
Tyr Ser Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65
70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp
Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys Gly Gly Gly 100 105 110
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115
120 125 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser
Leu Ser Ser 145 150 155 160 Tyr Trp Leu Thr Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp 165 170 175 Val Gly Thr Ile Ala Thr Ser Ser
Thr Tyr Tyr Ala Ser Trp Ala Lys 180 185 190 Gly Arg Phe Thr Ile Ser
Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205 Gln Leu Asn Ser
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Gly
Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly Thr 225 230 235
240 Leu Val Thr Val Ser Ser Gly Met 245 <210> SEQ ID NO 332
<211> LENGTH: 249 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: 31A12 pI optimization <400>
SEQUENCE: 332 Met Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr
Arg Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp Asp Thr 85 90 95 Thr
Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly 100 105
110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
115 120 125 Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Lys Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly
Phe Ser Leu Ser 145 150 155 160 Ser Tyr Trp Leu Thr Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Gly Thr Ile Ala Thr
Ser Ser Thr Tyr Tyr Ala Ser Trp Ala 180 185 190 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 195 200 205 Leu Gln Leu
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala
Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu Trp Gly Gln Gly 225 230
235 240 Thr Leu Val Thr Val Ser Ser Gly Met 245 <210> SEQ ID
NO 333 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: 31A12 combnd pI optimiz and
F12S mut <400> SEQUENCE: 333 Met Ala Asp Ile Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Glu Asp Ile Glu 20 25 30 Ser Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile
Tyr Ser Ala Ser Thr Arg Thr Ser Gly Val Pro Ser Arg Phe 50 55 60
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65
70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ala Asp
Asp Thr 85 90 95 Thr Thr Val Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys Arg Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Lys Pro 130 135 140 Gly Gly Ser Leu Arg Leu
Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 145 150 155 160 Ser Tyr Trp
Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp
Val Gly Thr Ile Ala Thr Ser Ser Thr Tyr Tyr Ala Ser Trp Ala 180 185
190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
195 200 205 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 210 215 220 Ala Arg Gly Leu Thr Thr Asp Tyr Asp Leu Asp Leu
Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Ser Gly Met
245 <210> SEQ ID NO 334 <211> LENGTH: 256 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: 13A18
pI optimization <400> SEQUENCE: 334 Met Ala Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 1 5 10 15 Val Gly Asp Arg
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 20 25 30 Asn Glu
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45
Leu Ile Tyr Arg Ala Ser Thr Arg Thr Ser Gly Val Pro Ser Arg Phe 50
55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser
Leu 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
Tyr Asn Ser 85 90 95 Asn Asp Val Asp Asn Val Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys 100 105 110 Arg Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu 130 135 140 Val Lys Pro Gly Gly
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile 145 150 155 160 Asp Leu
Ser Ser Tyr Asp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys 165 170 175
Gly Leu Glu Trp Val Gly Tyr Ile Tyr Thr Asp Ser Ser Thr Trp Tyr 180
185 190 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu
Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg Gly Ser Thr Asp Tyr
Ala Phe Asp Thr Arg 225 230 235 240 Leu Asp Leu Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Met 245 250 255 <210> SEQ ID NO
335 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: CDR2 region <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(6)..(6) <223> OTHER INFORMATION: Xaa selected from gly, asp,
gln, cys, ser, thr and tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (9)..(9) <223> OTHER
INFORMATION: Xaa selected from phe, trp and tyr <400>
SEQUENCE: 335 Tyr Ile Tyr Thr Asp Xaa Ser Thr Xaa Tyr Ala Asn Trp
Ala Lys Gly 1 5 10 15 <210> SEQ ID NO 336 <211> LENGTH:
7 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: CDR5 region <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is alanine or threonine. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (6)..(6)
<223> OTHER INFORMATION: Xaa is alanine or threonine.
<400> SEQUENCE: 336 Arg Xaa Ser Thr Leu Xaa Ser 1 5
<210> SEQ ID NO 337 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: CDR2 region <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (4)..(4) <223> OTHER
INFORMATION: Xaa selected from ser, pro and asp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(7)..(7) <223> OTHER INFORMATION: Xaa selected from lys and
gln <400> SEQUENCE: 337 Tyr Tyr Ala Xaa Trp Ala Xaa Gly 1 5
<210> SEQ ID NO 338 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR5 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is selected
from the group consisting of serine and alanine <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(5)..(5) <223> OTHER INFORMATION: Xaa selected from ala and
thr <400> SEQUENCE: 338 Ala Xaa Thr Leu Xaa Ser 1 5
<210> SEQ ID NO 339 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: CDR3 region
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa is alanine or
isoleucine <400> SEQUENCE: 339 Tyr Ala Tyr Xaa Gly Asp Ala
Phe Asp Pro 1 5 10 <210> SEQ ID NO 340 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: CDR3 region <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (6)..(6) <223> OTHER
INFORMATION: Xaa is isoleucine or valine <400> SEQUENCE: 340
Ser Asp Tyr Phe Asn Xaa 1 5 <210> SEQ ID NO 341 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: CDR5 region <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa is lysine or threonine <400> SEQUENCE: 341
Ala Ser Xaa Leu Ala 1 5 <210> SEQ ID NO 342 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: CDR6 region <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (6)..(6) <223> OTHER
INFORMATION: Xaa is is alanine or valine <400> SEQUENCE: 342
Gln Ser Tyr Tyr Asp Xaa Asn Ala Gly Tyr Gly 1 5 10 <210> SEQ
ID NO 343 <211> LENGTH: 679 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct <400> SEQUENCE: 343
gtacaaaaaa gcaggctcca ccatgaactc cttctccaca agcgccttcg gtccagttgc
60 cttctccctg gggctgctcc tggtgttgcc tgctgccttc cctgccccag
tacccccagg 120 agaagattcc aaagatgtag ccgccccaca cagacagcca
ctcacctctt cagaacgaat 180 tgacaaacaa attcggtaca tcctcgacgg
catctcagcc ctgagaaagg agacatgtaa 240 caagagtaac atgtgtgaaa
gcagcaaaga ggcactggca gaaaacaacc tgaaccttcc 300 aaagatggct
gaaaaagatg gatgcttcca atctggattc aatgaggaga cttgcctggt 360
gaaaatcatc actggtcttt tggagtttga ggtataccta gagtacctcc agaacagatt
420 tgagagtagt gaggaacaag ccagagctgt gcagatgagt acaaaagtcc
tgatccagtt 480 cctgcagaaa aaggcaaaga atctagatgc aataaccacc
cctgacccaa ccacaaatgc 540 cagcctgctg acgaagctgc aggcacagaa
ccagtggctg caggacatga caactcatct 600 cattctgcgc agctttaagg
agttcctgca gtccagcctg agggctcttc ggcaaatgta 660 ggacccagct
ttcttgtac 679 <210> SEQ ID NO 344 <211> LENGTH: 212
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 344 Met Asn Ser Phe Ser Thr Ser Ala
Phe Gly Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu Leu Leu Val Leu
Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 20 25 30 Gly Glu Asp Ser
Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 35 40 45 Ser Ser
Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 50 55 60
Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 65
70 75 80 Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys
Met Ala 85 90 95 Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu
Glu Thr Cys Leu 100 105 110 Val Lys Ile Ile Thr Gly Leu Leu Glu Phe
Glu Val Tyr Leu Glu Tyr 115 120 125 Leu Gln Asn Arg Phe Glu Ser Ser
Glu Glu Gln Ala Arg Ala Val Gln 130 135 140 Met Ser Thr Lys Val Leu
Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 145 150 155 160 Leu Asp Ala
Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 165 170 175 Thr
Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 180 185
190 Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala
195 200 205 Leu Arg Gln Met 210 <210> SEQ ID NO 345
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Amino terminal triple FLAG tag
<400> SEQUENCE: 345 Asp His Asp Gly Asp Tyr Lys Asp His Asp
Ile Asp Tyr Lys Asp Asp 1 5 10 15 Asp Asp <210> SEQ ID NO 346
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Carboxyl-terminal Avi tag
<400> SEQUENCE: 346 Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys
Ile Glu Trp His Glu 1 5 10 15 <210> SEQ ID NO 347 <211>
LENGTH: 639 <212> TYPE: DNA <213> ORGANISM: Macaca
mulatta <400> SEQUENCE: 347 atgaactcct tctccacaag cgccttcggt
ccagttgcct tctccctggg gctgctcctg 60 gtgttgcctg ctgccttccc
cgccccagta ctcccaggag aagattccaa aaatgtagcc 120 gccccacaca
gccagccact gacctcttca gaacgaattg acaaacacat tcggtacatc 180
ctcgacggca tctcagccct gagaaaggag acatgtaaca ggagtaacat gtgtgaaagc
240 agcaaagagg cactggcaga aaacaacctg aaccttccaa agatggctga
aaaagatgga 300 tgcttccaat ctggattcaa tgaggacact tgcctggtga
aaatcatcac tggtcttttg 360 gagtttgagg tatacctaga gtacctccag
aacaggtttg agagtagtga ggagcaagcc 420 agagctgtgc aaatgagtac
aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat 480 ctagatgcaa
taaccacccc tgaaccaacc acaaatgcca gcctgctgac gaagctgcag 540
gcacagaacc agtggctgca ggacatgacg acgcatctca tcctgcgcag ctttaaggag
600
ttcctgcagt ccaacctgag ggctcttcgg caaatgtag 639 <210> SEQ ID
NO 348 <211> LENGTH: 212 <212> TYPE: PRT <213>
ORGANISM: Macaca mulatta <400> SEQUENCE: 348 Met Asn Ser Phe
Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu
Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Leu Pro 20 25 30
Gly Glu Asp Ser Lys Asn Val Ala Ala Pro His Ser Gln Pro Leu Thr 35
40 45 Ser Ser Glu Arg Ile Asp Lys His Ile Arg Tyr Ile Leu Asp Gly
Ile 50 55 60 Ser Ala Leu Arg Lys Glu Thr Cys Asn Arg Ser Asn Met
Cys Glu Ser 65 70 75 80 Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn
Leu Pro Lys Met Ala 85 90 95 Glu Lys Asp Gly Cys Phe Gln Ser Gly
Phe Asn Glu Asp Thr Cys Leu 100 105 110 Val Lys Ile Ile Thr Gly Leu
Leu Glu Phe Glu Val Tyr Leu Glu Tyr 115 120 125 Leu Gln Asn Arg Phe
Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 130 135 140 Met Ser Thr
Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 145 150 155 160
Leu Asp Ala Ile Thr Thr Pro Glu Pro Thr Thr Asn Ala Ser Leu Leu 165
170 175 Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr
His 180 185 190 Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Asn
Leu Arg Ala 195 200 205 Leu Arg Gln Met 210 <210> SEQ ID NO
349 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Amino terminal signal
sequence <400> SEQUENCE: 349 Met Asn Ser Phe Ser Thr Ser Ala
Phe Gly Pro Val Ala Phe Ser Leu 1 5 10 15 Gly Leu Leu Leu Val Leu
Pro Ala Ala Phe Pro Ala Pro 20 25 <210> SEQ ID NO 350
<211> LENGTH: 3423 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 350 ctccctcttt
ccctcacagc cgacgaggca acaattaggc tttggggata aaacgaggtg 60
cggagagcgg gctggggcat ttctccccga gatggcgggt ctgacggcgg cggccccgcg
120 gcccggagtc ctcctgctcc tgctgtccat cctccacccc tctcggcctg
gaggggtccc 180 tggggccatt cctggtggag ttcctggagg agtcttttat
ccaggggctg gtctcggagc 240 ccttggagga ggagcgctgg ggcctggagg
caaacctctt aagccagttc ccggagggct 300 tgcgggtgct ggccttgggg
cagggctcgg cgccttcccc gcagttacct ttccgggggc 360 tctggtgcct
ggtggagtgg ctgacgctgc tgcagcctat aaagctgcta aggctggcgc 420
tgggcttggt ggtgtcccag gagttggtgg cttaggagtg tctgcaggtg cggtggttcc
480 tcagcctgga gccggagtga agcctgggaa agtgccgggt gtggggctgc
caggtgtata 540 cccaggtggc gtgctcccag gagctcggtt ccccggtgtg
ggggtgctcc ctggagttcc 600 cactggagca ggagttaagc ccaaggctcc
aggtgtaggt ggagcttttg ctggaatccc 660 aggagttgga ccctttgggg
gaccgcaacc tggagtccca ctggggtatc ccatcaaggc 720 ccccaagctg
cctggtggct atggactgcc ctacaccaca gggaaactgc cctatggcta 780
tgggcccgga ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt
840 tggcccccag gcagcagcag cagcggcagc taaagcagca gcaaagttcg
gtgctggagc 900 agccggagtc ctccctggtg ttggaggggc tggtgttcct
ggcgtgcctg gggcaattcc 960 tggaattgga ggcatcgcag gcgttgggac
tccagctgca gctgcagctg cagcagcagc 1020 cgctaaggca gccaagtatg
gagctgctgc aggcttagtg cctggtgggc caggctttgg 1080 cccgggagta
gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg 1140
gattccagtt gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc
1200 agaagcagct gctaaggcag ctgcaaaggc agccaaatac ggggccaggc
ccggagtcgg 1260 agttggaggc attcctactt acggggttgg agctgggggc
tttcccggct ttggtgtcgg 1320 agtcggaggt atccctggag tcgcaggtgt
ccctggtgtc ggaggtgttc ccggagtcgg 1380 aggtgtcccg ggagttggca
tttcccccga agctcaggca gcagctgccg ccaaggctgc 1440 caagtacggg
ttagttcctg gtgtcggcgt ggctcctgga gttggcgtgg ctcctggtgt 1500
cggtgtggct cctggagttg gcttggctcc tggagttggc gtggctcctg gagttggtgt
1560 ggctcctggc gttggcgtgg ctcccggcat tggccctggt ggagttgcag
ctgcagcaaa 1620 atccgctgcc aaggtggctg ccaaagccca gctccgagct
gcagctgggc ttggtgctgg 1680 catccctgga cttggagttg gtgtcggcgt
ccctggactt ggagttggtg ctggtgttcc 1740 tggacttgga gttggtgctg
gtgttcctgg cttcggggca gtacctggag ccctggctgc 1800 cgctaaagca
gccaaatatg gagcagcagt gcctggggtc cttggagggc tcggggctct 1860
cggtggagta ggcatcccag gcggtgtggt gggagccgga cccgccgccg ccgctgccgc
1920 agccaaagct gctgccaaag ccgcccagtt tggcctagtg ggagccgctg
ggctcggagg 1980 actcggagtc ggagggcttg gagttccagg tgttgggggc
cttggaggta tacctccagc 2040 tgcagccgct aaagcagcta aatacggtgc
tgctggcctt ggaggtgtcc tagggggtgc 2100 cgggcagttc ccacttggag
gagtggcagc aagacctggc ttcggattgt ctcccatttt 2160 cccaggtggg
gcctgcctgg ggaaagcttg tggccggaag agaaaatgag cttcctagga 2220
cccctgactc acgacctcat caacgttggt gctactgctt ggtggagaat gtaaaccctt
2280 tgtaacccca tcccatgccc ctccgactcc ccaccccagg agggaacggg
caggccgggc 2340 ggccttgcag atccacaggg caaggaaaca agaggggagc
ggccaagtgc cccgaccagg 2400 aggcccccta cttcagaggc aagggccatg
tggtcctggc cccccacccc atcccttccc 2460 acctaggagc tccccctcca
cacagcctcc atctccaggg gaacttggtg ctacacgctg 2520 gtgctcttat
cttcctgggg ggagggagga gggaagggtg gcccctcggg gaacccccta 2580
cctggggctc ctctaaagat ggtgcagaca cttcctgggc agtcccagct ccccctgccc
2640 accaggaccc accgttggct gccatccagt tggtacccaa gcacctgaag
cctcaaagct 2700 ggattcgctc tagcatccct cctctcctgg gtccacttgg
ccgtctcctc cccaccgatc 2760 gctgttcccc acatctgggg cgcttttggg
ttggaaaacc accccacact gggaatagcc 2820 accttgccct tgtagaatcc
atccgcccat ccgtccattc atccatcggt ccgtccatcc 2880 atgtccccag
ttgaccgccc ggcaccacta gctggctggg tgcacccacc atcaacctgg 2940
ttgacctgtc atggccgcct gtgccctgcc tccaccccca tcctacactc ccccagggcg
3000 tgcggggctg tgcagactgg ggtgccaggc atctcctccc cacccggggt
gtccccacat 3060 gcagtactgt atacccccca tccctccctc ggtccactga
acttcagagc agttcccatt 3120 cctgccccgc ccatcttttt gtgtctcgct
gtgatagatc aataaatatt ttattttttg 3180 tcctggatat ttggggatta
tttttgattg ttgatattct cttttggttt tattgttgtg 3240 gttcattgaa
aaaaaaagat aatttttttt tctgatccgg ggagctgtat ccccagtaga 3300
aaaaacattt taatcactct aatataactc tggatgaaac acaccttttt ttttaataag
3360 aaaagagaat taactgcttc agaaatgact aataaatgaa aaacctttaa
aggaaaaaaa 3420 aaa 3423 <210> SEQ ID NO 351 <211>
LENGTH: 30 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Elastin linker <400> SEQUENCE: 351
gttcctggag taggggtacc tggggtgggc 30 <210> SEQ ID NO 352
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Sequence encoded by SEQ ID NO: 351
<400> SEQUENCE: 352 Val Pro Gly Val Gly Val Pro Gly Val Gly 1
5 10 <210> SEQ ID NO 353 <211> LENGTH: 328 <212>
TYPE: PRT <213> ORGANISM: Macaca mulatta <400>
SEQUENCE: 353 Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu
Val Phe Leu 1 5 10 15 Ala Ser Pro Leu Met Ala Ile Trp Glu Leu Lys
Lys Asp Val Tyr Val 20 25 30 Val Glu Leu Asp Trp Tyr Pro Asp Ala
Pro Gly Glu Met Val Val Leu 35 40 45 Thr Cys Asp Thr Pro Glu Glu
Asp Gly Ile Thr Trp Thr Leu Asp Gln 50 55 60 Ser Gly Glu Val Leu
Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 65 70 75 80 Glu Phe Gly
Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 85 90 95 Leu
Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 100 105
110 Ser Thr Asp Val Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe
115 120 125
Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 130
135 140 Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser
Arg 145 150 155 160 Gly Ser Ser Asn Pro Gln Gly Val Thr Cys Gly Ala
Val Thr Leu Ser 165 170 175 Ala Glu Arg Val Arg Gly Asp Asn Lys Glu
Tyr Glu Tyr Ser Val Glu 180 185 190 Cys Gln Glu Asp Ser Ala Cys Pro
Ala Ala Glu Glu Arg Leu Pro Ile 195 200 205 Glu Val Met Val Asp Ala
Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr 210 215 220 Ser Ser Phe Phe
Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 225 230 235 240 Leu
Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 245 250
255 Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr
260 265 270 Phe Cys Ile Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys
Asp Arg 275 280 285 Ile Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys
Arg Lys Asn Ala 290 295 300 Ser Phe Ser Val Gln Ala Gln Asp Arg Tyr
Tyr Ser Ser Ser Trp Ser 305 310 315 320 Glu Trp Ala Ser Val Pro Cys
Ser 325 <210> SEQ ID NO 354 <211> LENGTH: 1080
<212> TYPE: DNA <213> ORGANISM: Macaca mulatta
<400> SEQUENCE: 354 gcccagagca agatgtgtca ccagcagctg
gtcatctctt ggttttccct ggtttttctg 60 gcatctcccc tcatggccat
atgggaactg aagaaagacg tttatgttgt agaattggac 120 tggtacccgg
atgcccctgg agaaatggtg gtcctcacct gtgacacccc tgaagaagat 180
ggtatcacct ggaccttgga ccagagtggt gaggtcttag gctctggcaa aaccctgacc
240 atccaagtca aagagtttgg agatgctggc cagtacacct gtcacaaagg
aggcgaggct 300 ctaagccatt cactcctgct gcttcacaaa aaggaagatg
gaatttggtc cactgatgtt 360 ttaaaggacc agaaagaacc caaaaataag
acctttctaa gatgtgaggc caaaaattat 420 tctggacgtt tcacctgctg
gtggctgacg acaatcagta ctgatctgac attcagtgtc 480 aaaagcagca
gaggctcttc taacccccaa ggggtgacgt gtggagccgt tacactctct 540
gcagagaggg tcagagggga caataaggag tatgagtact cagtggagtg ccaggaggac
600 agtgcctgcc cagccgctga ggagaggctg cccattgagg tcatggtgga
tgccattcac 660 aagctcaagt atgaaaacta caccagcagc ttcttcatca
gggacatcat caaacccgac 720 ccacccaaga acttgcagct gaagccatta
aagaattctc ggcaggtgga ggtcagctgg 780 gagtaccctg acacctggag
tactccacat tcctacttct ccctgacatt ctgcatccag 840 gtccagggca
agagcaagag agaaaagaaa gatagaatct tcacagacaa gacctcagcc 900
acggtcatct gccgcaaaaa tgccagcttt agcgtgcagg cccaggaccg ctactatagc
960 tcatcttgga gcgaatgggc atctgtgccc tgcagttagg ttgtgatccc
aggatgaaaa 1020 attggaggaa aagtagaaga tattaaccaa aacgtttaaa
gacacaacgg aatagaccca 1080 <210> SEQ ID NO 355 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Framework VH back mutations (H23-30)
<400> SEQUENCE: 355 Ala Ala Ser Gly Ile Asp Leu Ser 1 5
<210> SEQ ID NO 356 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Oryctolagus cuniculus <400>
SEQUENCE: 356 Thr Val Ser Gly Ile Asp Leu Ser 1 5 <210> SEQ
ID NO 357 <211> LENGTH: 287 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 357 gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca
120 gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg
ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca
caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag
cttaatagtt accctcc 287 <210> SEQ ID NO 358 <211>
LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: CDR2 region <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa selected from ala, val, leu, ile, pro, phe, met
and trp <400> SEQUENCE: 358 Trp Xaa Lys Gly 1 <210> SEQ
ID NO 359 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: CDR4 region <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(2)..(2) <223> OTHER INFORMATION: Xaa is selected from the
group consisting of alanine and serine <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa selected from gly, asn, gln,
cys, ser, thr and tyr <400> SEQUENCE: 359 Gln Xaa Ser Gln Xaa
1 5
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