U.S. patent application number 14/055955 was filed with the patent office on 2014-04-17 for methods and means for treatment of osteoarthritis. This patent application is currently assigned to GALAPAGOS N.V.. The applicant listed for this patent is GALAPAGOS N.V.. Invention is credited to Libin Ma, Frits Michiels, Blandine Mille-Baker, Peter Herwig Maria Tomme, Helmuth H.G. van Es, Nick Vandeghinste.
Application Number | 20140107181 14/055955 |
Document ID | / |
Family ID | 35510369 |
Filed Date | 2014-04-17 |
United States Patent Application | 20140107181 |
Kind Code | A1 |
Vandeghinste; Nick ; et al. | April 17, 2014 |
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.
Inventors: | Vandeghinste; Nick; (Duffel, BE) ; Tomme; Peter Herwig Maria; (Gent, BE) ; Michiels; Frits; (Leiderdorp, NL) ; Ma; Libin; (Oegstgeest, NL) ; Mille-Baker; Blandine; (Oegstgeest, NL) ; van Es; Helmuth H.G.; (Haarlem, NL) | ||||||||||
Applicant: |
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Assignee: | GALAPAGOS N.V. MECHELEN BE |
||||||||||
Family ID: | 35510369 | ||||||||||
Appl. No.: | 14/055955 | ||||||||||
Filed: | October 17, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13360393 | Jan 27, 2012 | 8574857 | ||
14055955 | ||||
12575220 | Oct 7, 2009 | |||
13360393 | ||||
11158252 | Jun 21, 2005 | |||
12575220 | ||||
60581568 | Jun 21, 2004 | |||
Current U.S. Class: | 514/44A ; 435/6.12; 436/87; 506/9; 536/24.5 |
Current CPC Class: | C07H 21/04 20130101; C12N 2310/14 20130101; C12Q 1/6883 20130101; C12N 2320/12 20130101; A61P 35/00 20180101; A61K 48/00 20130101; C12Q 2600/158 20130101; C12Q 2600/136 20130101; A61P 19/02 20180101; C12N 15/111 20130101; A61K 38/1709 20130101; G01N 33/6893 20130101; A61P 5/14 20180101; G01N 33/5008 20130101; G01N 2800/105 20130101; A61P 17/00 20180101; Y10T 436/143333 20150115; G01N 33/6887 20130101; A61P 19/08 20180101; A61P 19/00 20180101 |
Class at Publication: | 514/44.A ; 536/24.5; 506/9; 436/87; 435/6.12 |
International Class: | C07H 21/04 20060101 C07H021/04; G01N 33/68 20060101 G01N033/68; C12Q 1/68 20060101 C12Q001/68; G01N 33/50 20060101 G01N033/50 |
Sequence CWU 1
1
48013536DNAHomo sapiens 1atggggacga cggccccagg gcccattcac
ctgctggagc tatgtgacca gaagctcatg 60gagtttctct gcaacatgga taataaggac
ttggtgtggc ttgaggagat ccaagaggag 120gccgagcgca tgttcaccag
agaattcagc aaagagccag agctgatgcc caaaacacct 180tctcagaaga
accgacggaa gaagagacgg atttcttatg ttcaggatga aaacagagat
240cccatcagga gaaggttatc ccgcagaaag tctcggagca gccagctgag
ctcccgacgc 300ctccgcagca aggacagtgt agagaagctg gctacagtgg
tcggggagaa cggctccgtt 360ctgcggcgtg tgacccgtgc tgcggctgca
gctgccgcgg ctaccatggc attggctgca 420ccttcttcac ccacccctga
gtctcccacg atgctgacta agaagcccga ggataaccac 480acccagtgcc
agctggtgcc tgtggtggag atcggcatca gtgagcgcca gaatgctgag
540cagcatgtca cccagctcat gtccaccgag cctctgcccc gcactctgtc
cccgactcca 600gcttcagcca cagctccaac ctcccagggc atcccgacat
cagatgagga atcaacacct 660aagaagtcga aggccaggat actggagtcc
atcacagtga gctccctgat ggctacaccc 720caggacccca agggtcaagg
ggtcgggacg gggcggtctg cgtctaagct caggattgcg 780caggtctccc
ctggcccacg ggactcgcca gcctttccag attctccatg gcgggagcgg
840gtgctggctc ccatcctgcc ggataacttc tccacgccca cgggctctcg
cacggactct 900caatcggtgc ggcacagccc gatcgccccg tcttccccga
gtccccaagt cttagcccag 960aagtactctc tggtggccaa acaggaaagt
gttgtccgca gggcgagcag aaggcttgcc 1020aagaagactg ccgaagagcc
agctgcctct ggccgcatca tctgtcacag ttacctggag 1080aggctcctga
atgttgaggt gccccagaaa gttggttctg agcagaagga accccccgag
1140gaggctgagc ctgtggcggc agctgagcca gaggtccctg agaacaacgg
aaataactcg 1200tggccccaca atgacacgga gattgccaac agcacaccca
acccgaagcc tgcagccagc 1260agcccggaaa caccctctgc agggcagcaa
gaggccaaga cggaccaagc agatggaccc 1320agagagccac cgcagagtgc
caggaggaag cgcagctaca agcaggccgt gagtgagctg 1380gacgaggagc
agcacctgga ggatgaggag ctgcagcccc ccaggagcaa gaccccttcc
1440tcaccctgcc cagccagcaa ggtggtacgg cccctccgga cctttctgca
cacagtgcag 1500aggaaccaga tgctcatgac ccctacctca gccccacgca
gcgtcatgaa gtcctttatt 1560aagcgcaaca ctcccctgcg catggacccc
aaggagaagg agcggcagcg cctggagaat 1620ctgcggcgga aggaggaggc
cgagcagctg cgcaggcaga aggtggagga ggacaagcgg 1680cggcggctgg
aggaggtgaa gctgaagcgt gaggaacgcc tccgcaaggt gctgcaggcc
1740cgcgagcggg tggagcagat gaaggaggag aagaagaagc agattgagca
gaagtttgct 1800cagatcgacg agaagactga gaaggccaag gaggagcggc
tggcagagga gaaggccaag 1860aaaaaggcgg cggccaagaa gatggaggag
gtggaagcac gcaggaagca ggaagaggat 1920gcacgtaggc tcaggtggct
gcagcaggag gaggaagagc ggcggcacca agagctgctg 1980cagaagaaga
aggaagagga gcaggagcgg ctgcggaagg cggccgaggc taagcggctg
2040gcagagcagc gggagcagga gcggcgggag caggagcggc gggagcagga
gcggcgcgag 2100caggagcggc gcgagcagga gcggcgggag caggagcggc
gcgagcagga gcgacagctg 2160gcagagcagg agcgtcggcg ggagcaggag
cggctccaag ccgagaggga gctgcaggag 2220cgggagaagg ccctgcggct
gcagaaggag cagctgcaga gggaactgga ggagaagaag 2280aagaaggaag
agcagcagcg tctggctgag cggcagctgc aggaggagca agagaagaaa
2340gccaaggagg cagcaggggc cagcaaggcc ctgaatgtga ctgtggacgt
gcagtctcca 2400gcttgtacct catctcccat cactccgcaa gggcacaagg
cccctcccca gatcaacccc 2460cacaactacg ggatggatct gaatagcgac
gactccaccg atgatgaggc ccatccccgg 2520aagcccatcc ccacctgggc
ccgaggcacc ccgctcagcc aggctatcat tcaccagtac 2580taccagccac
cgaaccttct ggagctcttt ggaaccattc tcccactgga cttggaggat
2640atcttcaaga agagcaagcc ccgctatcac aagcgcacca gctctgctgt
ctggaactca 2700ccgcccctgc agggcgccag ggtccccagc agcctggcct
acagcctgaa gaagcactga 2760ggctggcctg cggccttctt ggcagcctcg
cctcctgtcc atgtctatct gtctgtctgt 2820cggtctgtgt cttggtctgt
tgccctcctt cttggcatgc cattgtggag ggcttggcca 2880ggtgtatata
aacgtcctct gtgctgggtg tttctgctgc aggtggcagg tggccccagg
2940cctgtttgga ggatgggctg ggtgggtggg tggggaagaa atgggcccag
ccccacatgg 3000cctgcagaca gtgctctgta aatagttgtt ttaatttagc
tgaatgttag cattttagtc 3060tttggcattt tagcgtttgg gaggtagatt
aataaagtat attccttcaa gcctgctgtt 3120gataccatga agactgggcg
cctcagtccc agccctgtag ctgtgtgtct tgggccacca 3180gtggcctgca
ggacgaaggt actgttccat cacctgcggt gtgcctcagg atcaccaggt
3240gcaggccccc accctcggag atgctgctgc agtgagtggt tccactgcct
ggataaccct 3300tgaggaacac gtcagttact gtcacgatgg ggcaggtgga
gctccttcct attttttggg 3360gtgctccctg tttgtaaagg ggagtttgtt
cattgggaaa gacctgggtc ttgacacggc 3420cctgccactt agtcccctac
cctctccatt ccccaggctc cacccgtgct gctcaagtgc 3480aaatggactt
gagagtattt atgtgctggt gaagtatgag gtctgagtag aaaagg 353623926DNAHomo
sapiens 2atgacaaacc aggaaaaatg ggcccacctc agcccttcgg aattttccca
acttcagaaa 60tatgctgagt attctacaaa gaaattaaag gatgttcttg aagaattcca
tggtaatggt 120gtgcttgcaa agtataatcc tgaagggaaa caagacattc
ttaaccaaac aatagatttt 180gaaggtttca aactattcat gaagacattc
ctggaagccg agcttcctga tgatttcact 240gcacaccttt tcatgtcatt
tagcaacaag tttcctcatt ctagtccaat ggtaaaaagt 300aagcctgctc
tcctatcagg cggtctgaga atgaataaag gtgccatcac ccctccccga
360actacttctc ctgcaaatac gtgttcccca gaagtaatcc atctgaagga
cattgtctgt 420tacctgtctc tgcttgaaag aggaagacct gaggataagc
ttgagtttat gtttcgcctt 480tatgacacgg atgggaatgg cttcctggac
agctcggagc tagaaaatat catcagtcag 540atgatgcatg ttgcagaata
ccttgagtgg gatgtcactg aacttaatcc aatcctccat 600gaaatgatgg
aagaaattga ctatgatcat gatggaaccg tgtctctgga ggaatggatt
660caaggaggaa tgacaacgat tccacttctt gtgctcctgg gcttagaaaa
taacgtgaag 720gatgatggac agcacgtgtg gcgactgaag cactttaaca
aacctgccta ttgcaacctt 780tgcctgaaca tgctgattgg cgtggggaag
cagggcctct gctgttcctt ctgcaagtac 840acagtccatg agcgctgtgt
ggctcgagca cctccctctt gcatcaagac ctatgtgaag 900tccaaaagga
acactgatgt catgcaccat tactgggttg aaggtaactg cccaaccaag
960tgtgataagt gccacaaaac tgttaaatgt taccagggcc tgacaggact
gcattgtgtt 1020tggtgtcaga tcacactgca taataaatgt gcttctcatc
taaaacctga atgtgactgt 1080ggacctttga aggaccatat tttaccaccc
acaacaatct gtccagtggt actgcagact 1140ctgcccactt caggagtttc
agttcctgag gaaagacaat caacagtgaa aaaggaaaag 1200agtggttccc
agcagccaaa caaagtgatt gacaagaata aaatgcaaag agccaactct
1260gttactgtag atggacaagg cctgcaggtc actcctgtgc ctggtactca
cccactttta 1320gtttttgtga accccaaaag tggtggaaaa caaggagaac
gaatttacag aaaattccag 1380tatctattaa atcctcgtca ggtttacagt
ctttctggaa atggaccaat gccagggtta 1440aactttttcc gtgatgttcc
tgacttcaga gtgttagcct gtggtggaga tggaaccgtg 1500ggctgggttt
tggattgcat agaaaaggcc aatgtaggca agcatcctcc agttgcgatt
1560ctgcctcttg ggactggcaa tgatctagca agatgcctgc gatggggagg
aggttacgaa 1620ggtgagaatc tgatgaaaat tctaaaagac attgaaaaca
gcacagaaat catgttggac 1680aggtggaagt ttgaagtcat acctaatgac
aaagatgaga aaggagaccc agtgccttac 1740agtatcatca ataattactt
ttccattggc gtggatgcct ccattgcaca cagattccac 1800atcatgagag
aaaaacaccc agagaaattc aacagtagaa tgaagaacaa attttggtat
1860tttgagtttg gcacatctga aactttctca gccacctgca agaagctaca
tgaatctgta 1920gaaatagaat gtgatggagt acagatagat ttaataaaca
tctctctgga aggaattgct 1980attttgaata taccaagcat gcatggagga
tccaatcttt ggggagagtc taagaaaaga 2040cgaagccatc gacgaataga
gaaaaaaggg tctgacaaaa ggaccaccgt cacagatgcc 2100aaagagttga
agtttgcaag tcaagatctc agtgaccagc tgctggaggt ggtcggcttg
2160gaaggagcca tggagatggg gcaaatatac acaggcctga aaagtgctgg
ccggcggctg 2220gctcagtgct cctgcgtggt catcaggacg agcaagtctc
tgccaatgca aattgatggg 2280gagccatgga tgcagacccc atgcacaata
aaaattacac acaagaacca agccccaatg 2340ctgatgggcc cgcctccaaa
aaccggttta ttctgctccc tcgtcaaaag gacaagaaac 2400cgaagcaagg
aataatcctg tgttgtttca ctcttagaaa ttgaattagc ataattgggc
2460catggaacac atatgctgga aatctttgaa ccatttcaag tctcctgctc
atgcaaaatc 2520atggaagtgg tttaacagtt tttgttacta agctaatgta
aaattcagct attagaaaat 2580ttattgtctc agtttttata ggcatctttg
catgaagaaa gcagaagttt acctgaagtg 2640atactgcata tttttggtgc
atgcattccc atagattttt acatctccca cccaactctt 2700ccccaatttc
cttttactaa cctgtgagaa aaacccgtga aacatgaaaa aggaaatacc
2760atgggaaacg tgattctcag tgtgattcca attattacga agcactaatc
agtaacgcta 2820caatgatcat aattgcagat tgctatacgt ttccctttta
gaatcagtgt atcagtgacc 2880tatgacttga ggagaaactt ttaattcgaa
gattttatta aatagttgac tacaatacct 2940tgctatatat acatagtttt
tcttcaacat cttaactctt ctgagtggaa ataaaaatat 3000caggcataag
gttttctcat gctgaaaaat agaacgcggt ttttattttg cttagttttc
3060tttttaattc cagaaataag tgaaaacatg ttacttgaca gtcaagtgtg
gtaatatggc 3120aagccttgtt cctttctgca tgagaatcta ggagagaatt
cataaccaca ccaataacga 3180aatagaagtt ttaaactatg tgcctaatca
atgtgtttcc caccaaagat tcagaaaaca 3240atgcttgaga gaaatgggtt
aatgcataat taattaagca ttgtggagca aatttagggt 3300tcctgtgatt
aattttgtga tgactaaaat gctggaaagc aagtgagttg cccattaatt
3360atgattaaaa ttctcacctt tcacagacag acaataagcc agacaacaca
atcaaagctc 3420aatagatgat ttcttgcttt tttcagtcat ttataaatat
aggtgtaatt tttcatggat 3480cagttaagta cacttgaagg aagtaaatga
ttgtatcagt ttatttctag tataaatggg 3540tacctgtaat aatactgagc
tcttggaagc gaatcatgca tgcaattagc tccctcctcc 3600tcacctactc
cactcccatc tttatgacat ttcaaatgtt tatttggaaa caacagccta
3660gatcactgtt gaaggtgttc atggcatagt tggagtctct gactgtttaa
agaaatcaca 3720gaacagtact tttcttttag tgtttcatta agcctatgat
gtaaaatgaa atgcttctga 3780gcagtcttgt aatattgttc attcatattg
acctgcatct catcattgca tgttttatgt 3840tttcaaacat gccataagga
aaacgagtgc ctgaactgca tgatttatta gtttctctcc 3900actctgcatt
aaagtgctaa tgattt 392633172DNAHomo sapiens 3atgacaaacc aggaaaaatg
ggcccacctc agcccttcgg aattttccca acttcagaaa 60tatgctgagt attctacaaa
gaaattaaag gatgttcttg aagaattcca tggtaatggt 120gtgcttgcaa
agtataatcc tgaagggaaa caagacattc ttaaccaaac aatagatttt
180gaaggtttca aactattcat gaagacattc ctggaagccg agcttcctga
tgatttcact 240gcacaccttt tcatgtcatt tagcaacaag tttcctcatt
ctagtccaat ggtaaaaagt 300aagcctgctc tcctatcagg cggtctgaga
atgaataaag gtgccatcac ccctccccga 360actacttctc ctgcaaatac
gtgttcccca gaagtaatcc atctgaagga cattgtctgt 420tacctgtctc
tgcttgaaag aggaagacct gaggataagc ttgagtttat gtttcgcctt
480tatgacacgg atgggaatgg cttcctggac agctcggagc tagaaaatat
catcagtcag 540atgatgcatg ttgcagaata ccttgagtgg gatgtcactg
aacttaatcc aatcctccat 600gaaatgatgg aagaaattga ctatgatcat
gatggaaccg tgtctctgga ggaatggatt 660caaggaggaa tgacaacgat
tccacttctt gtgctcctgg gcttagaaaa taacgtgaag 720gatgatggac
agcacgtgtg gcgactgaag cactttaaca aacctgccta ttgcaacctt
780tgcctgaaca tgctgattgg cgtggggaag cagggcctct gctgttcctt
ctgcaagtac 840acagtccatg agcgctgtgt ggctcgagca cctccctctt
gcatcaagac ctatgtgaag 900tccaaaagga acactgatgt catgcaccat
tactgggttg aaggtaactg cccaaccaag 960tgtgataagt gccacaaaac
tgttaaatgt taccagggcc tgacaggact gcattgtgtt 1020tggtgtcaga
tcacactgca taataaatgt gcttctcatc taaaacctga atgtgactgt
1080ggacctttga aggaccatat tttaccaccc acaacaatct gtccagtggt
actgcagact 1140ctgcccactt caggagtttc agttcctgag gaaagacaat
caacagtgaa aaaggaaaag 1200agtggttccc agcagccaaa caaagtgatt
gacaagaata aaatgcaaag agccaactct 1260gttactgtag atggacaagg
cctgcaggtc actcctgtgc ctggtactca cccactttta 1320gtttttgtga
accccaaaag tggtggaaaa caaggagaac gaatttacag aaaattccag
1380tatctattaa atcctcgtca ggtttacagt ctttctggaa atggaccaat
gccagggtta 1440aactttttcc gtgatgttcc tgacttcaga gtgttagcct
gtggtggaga tggaaccgtg 1500ggctgggttt tggattgcat agaaaaggcc
aatgtaggca agcatcctcc agttgcgatt 1560ctgcctcttg ggactggcaa
tgatctagca agatgcctgc gatggggagg aggttacgaa 1620ggtgagaatc
tgatgaaaat tctaaaagac attgaaaaca gcacagaaat catgttggac
1680aggtggaagt ttgaagtcat acctaatgac aaagatgaga aaggagaccc
agtgccttac 1740agtatcatca ataattactt ttccattggc gtggatgcct
ccattgcaca cagattccac 1800atcatgagag aaaaacaccc agagaaattc
aacagtagaa tgaagaacaa attttggtat 1860tttgagtttg gcacatctga
aactttctca gccacctgca agaagctaca tgaatctgta 1920gaaatagaat
gtgatggagt acagatagat ttaataaaca tctctctgga aggaattgct
1980attttgaata taccaagcat gcatggagga tccaatcttt ggggagagtc
taagaaaaga 2040cgaagccatc gacgaataga gaaaaaaggg tctgacaaaa
ggaccaccgt cacagatgcc 2100aaagagttga agtttgcaag tcaagatctc
agtgaccagc tgctggaggt ggtcggcttg 2160gaaggagcca tggagatggg
gcaaatatac acaggcctga aaagtgctgg ccggcggctg 2220gctcagtgct
cctgcgtggt catcaggacg agcaagtctc tgccaatgca aattgatggg
2280gagccatgga tgcagacccc atgcacagtg agtacagagt agttgatatg
ctatgtcaat 2340ctcagttttg ctttcctctt tgactaaata accacaataa
ctgatttttt tctttatttc 2400ttttcaacct atcagcaaat agtctttttg
ttgttgttgt tatgtgtgtg tcagagccac 2460tacatttagg ctgtagacat
tatataccct tggcaatgat ttagctcttg aatgtttgtg 2520ctagcctaag
tataaataga tcttttaaat agatcaatta taaaccatag atcaattata
2580aactatggag ctaaacaaaa tattaataaa agtttatctg aaactttttt
gtttatttca 2640gagcacatta ttagaatatt atttgcgaga aatgcagacc
taagcttata tgtgaactta 2700tttctcagct tttctatgcc tccatttggg
gatttgaggg ctttcttctc cataagaaaa 2760aaatttctct ccagtttcta
ccataattaa ttgtgttttc cagaatgagg tattatttaa 2820ggcagacact
gcccctctca aaaaaaatca gttttcattt gcatagtgaa tattttattg
2880catttcaaaa acatgctagg aactgctttt ggcactggga gtagacacat
gaacaagacc 2940aacagtgtaa tttccttcaa gttacttaca ttcctataat
agaggaccga ataaataaac 3000aactacatga taaatataac ttcagactgt
gagagttatt aaaaaataag gtgaaatgat 3060gataagaagc tggattaggt
gtggagaata aatactactt gagataaggg agacctcttt 3120gaaaggacat
agccaaaagc ttagtataaa attaaaaaaa ataaaaaaaa aa 317246228DNAHomo
sapiens 4cgggttcctg ctgcactacc atgcgccgtg cggcccgtgc gactcgccgg
acctcgcggg 60cgtccctgta cggagccctc ggccggtcct agcagggatt gtccccattt
ccagctccgg 120agcgggcggc tgcgccccgc tcgtcgagga gctgcgctca
cctcaggggc gggcccccgc 180ctgcgttcgc ggcgccaaga agagtattcc
tttccactta caactaaata agacctgctt 240ttgctggagc tgtgctaggc
tgagggaatt ccacactgaa ttttacaagc gggatggatt 300tctctaaggc
agaagactga tttttggaaa tatgtatttg ggagacagtc acgtcctatt
360gaataccttg tgctggtgct gccatcgaaa aatctggtta cactctgggg
aggactgcta 420ccactgcaga actgaaccac ttcggccgtg agatgagtgt
ccggcctgag caggcacacc 480atgaatagat acacaacaat caggcagctc
ggggatggaa cctacggttc cgtcctgctg 540ggaagaagca ttgagtctgg
ggagctgatc gctattaaaa aaatgaaaag aaaattttat 600tcctgggagg
aatgcatgaa ccttcgggag gttaagtctt taaagaagct caaccatgcc
660aatgtagtca aattaaaaga agttatcagg gaaaatgatc atctttattt
tatcttcgag 720tacatgaagg aaaatcttta ccagctcatt aaagagagaa
ataagttgtt tcctgagtct 780gctataagga atatcatgta tcagatatta
caaggactcg catttattca caaacacggc 840ttctttcatc gagacttaaa
gcctgagaac ctcctctgca tgggaccaga acttgtgaaa 900attgcagact
ttggtttggc ccgagaaata cgatcaaaac ctccatatac agattatgta
960tctaccagat ggtacagggc tccagaagta ctcctgaggt ctaccaacta
cagctccccc 1020attgacgtct gggcggtggg ctgcatcatg gcagaagttt
acaccctcag gccactcttc 1080cctggagcca gtgaaattga cacaatattc
aaaatttgcc aagtgctggg gacaccaaaa 1140aagactgact ggcctgaagg
ctatcaactt tcaagtgcaa tgaacttccg ttggccacag 1200tgtgtaccca
ataacttaaa gaccttgatt cccaatgcta gcagtgaagc agtccagctc
1260ctgagagaca tgcttcagtg ggatcccaag aaacgaccaa cagctagtca
ggcacttcga 1320tatccttact tccaagttgg acacccacta ggcagcacca
cacaaaacct tcaggattca 1380gaaaaaccac agaaaggcat cctggaaaag
gcaggcccac ctccttatat taagccagtc 1440ccacctgccc agccaccagc
caagccacac acacgaattt cttcacgaca gcatcaagcc 1500agccagcccc
ctctgcatct cacgtacccc tacaaagcag aggtctccag gacagatcac
1560ccaagccatc tccaggagga caagccaagc ccgttgcttt tcccatccct
ccacaacaag 1620catccacagt cgaaaatcac agctggcctg gagcacaaaa
atggtgagat aaagccaaag 1680agtaggagaa ggtggggtct tatttccagg
tcaacaaagg attcagatga ttgggctgac 1740ttggatgact tggatttcag
tccatccctc agcaggattg acctgaaaaa caagaaaaga 1800cagagtgatg
acactctctg caggtttgag agtgttttgg acctgaagcc ctctgagcct
1860gtgggcacag gaaacagtgc ccccacccag acgtcatatc agcggcgaga
cacgcccacc 1920ctgagatctg cagccaagca gcactatttg aagcactctc
gatacttgcc tgggatcagt 1980ataagaaatg gcatactctc gaatccaggc
aaggaattta ttccacctaa tccatggtct 2040agttctggct tgtctggaaa
atcttcaggg acaatgtcag taatcagcaa agtaaattca 2100gttggttcca
gctctacaag ttctagtgga ctgactggaa actatgtccc ttcctttctg
2160aaaaaagaaa tcggttctgc tatgcagagg gtacacctag cacctattcc
agacccttcc 2220cctggttatt cctccctgaa ggccatgaga cctcatcctg
ggcgaccatt cttccacacc 2280cagcctagaa gcactcctgg gttgatacca
cggcctccag ccgcccagcc agtgcatggc 2340cggacagact gggcttccaa
gtacgcatct cggcgatgac tgtctgcctt ggtgatgaat 2400ctcttcctag
ggagaagcag gatactttcc ctcagctgac tggtgttcta cctgcaagat
2460gtgcagaggg cataaaagca aatcaacact ttatagttat tcttctgaac
taagacatgt 2520caatattctt ttttaaagtt tttttttaaa atattgattt
gaatgcagta ggcttttttg 2580tataaaatta ttttattcta aaactgggtc
ccattatttt cttaaacaac agcattttgt 2640atatatggat tatgttttag
cattttatac agtcaacttt gtaatgaact ttttaaaaat 2700taattgattt
tcctttgggg ttccagataa tattttctac agattttgaa aaatgtaata
2760atattaatgc agtattgcaa caggggtgca atttaaggct atgtgataga
gggttattta 2820ctcagtgtgt gcagatattt atgaagtggt gaaatttcaa
gtgtggctca ctaggtactt 2880caggccttct tggactgttg ttagaaaagt
gatcctctgc ttttcttagt aggtcattgg 2940tttgattttt ggataccact
ctgctgttct aaaaggacta ttatattata taattcactt 3000tgttttactt
ttgttcccca gatgaaagaa ctctaagtaa atacatttta aaaaattttt
3060ctgacaccct ttaatgtggt tgcagatctc agatgaaacc aagcttaatt
atactatgcc 3120attatattct aatttattcc atttttgaaa tcaagttgta
tgtgtaccaa taaaagagat 3180ttctgcttca aaaggctctc aacatgaagg
ttaacacagt caatcaaact tacattcctg 3240ccaagatgca tggccaaaaa
actaagtatc aaagcagcag aaggtttttg attatagtaa 3300ctgagatgga
attttgtgcc tagctcagtt ctccagatct ggctaggagc agtcaatgac
3360taatgttctg tcctagccaa attctcagga caatttgggg agcagaaaga
gttatggcag 3420aggttccact catctacaaa gtcacagtca catgccacat
ttgatctcct aaccctggtg 3480tagtttcttt caagagtgag aactttattt
gttgggcaga ggctgttcca ttgagaggaa 3540tgtttacagc agtttcaaaa
atgacaaagt cagtttggag acagaaaaag acaaaaggtc 3600cagtctcatc
catctctata tggtacattt gcctcactta tggttgcctt aaaggcaaga
3660gggaaggtca ccatcagtga acgcaatgca atctcaacag tgtattgatt
catattctcc 3720tagggctcaa actactctct attggttcca ggataatgac
aaattgaacc atatgtaagt 3780aatcttttat tttttatttt ttttttgaga
cagagtctca ctctgtcacc caggctggag 3840tgcagtggcg cgatcttagc
tctctgcaac ctctgcctcc caggttcaag cctcctgagt 3900aactgggact
acaggcgccc gccaccacgc ccagctaatt ttttgtattt ttagtagaga
3960cggggtttca ctgtgttagc caggacggcc tcgatctcct gacctcgtga
tccaccctcc 4020tccacctccc aaagtactgg gattacaggc atgagccact
gcacccagcc aagtgatcat 4080ttttataggt taaaatgata ggtgaaatga
atatagacac tttcatatgg ttcaacctaa 4140tgacttggta aattattgcc
ttggtgtatt aataatatgt tgcattctga acaaataacc 4200atggcttcca
aagggcccta acctaaaatc ggagagtaat ttatgctttg gagaatttga
4260ctcaaatata tacttgacca agcaccatga tccctagggg
catgagaaaa gcacataatg 4320gatgtggatg tgataggtgg tcttttcctg
ttaacaagct ggcagcaaag cttcagaaaa 4380tatatatgca agcacaactt
gaagctgaat tcatttctgt attatattct caactcgtta 4440tctaaagcat
cagaacatgt gttttcagag atgagtcctt tactataagg ttaatattta
4500ttttcatttt ctgtattata tatgaaaagt aaattaatgt gaaacctggc
ccagcttgct 4560ggaaagcagg ttttaaattg taaatattcc ttagaggagc
aaatggattg tttaatacca 4620tagtctcagt aatctagctt atataaggtc
attacatttt ttaactgaaa aacctagtta 4680cctgattatt gcacattata
aaattgtttt tctaatactt tatagggccc aacttcagaa 4740aatacttcgc
ttttttcttt ttatgctttc gtttgtttac cagcaagcaa cttccctggg
4800gaagccaaac acatattcat aaaaaaaatc aagtagctga tgtgcagttg
agaaaactag 4860aggactgaaa aaacaaattt taactagcaa atgctgtgaa
ttactcttcc tccccttctc 4920tgaaatgggt aaaggacaaa ttgtgtaaaa
aaacctatgc actatagaag ggaatagtaa 4980ccatttcttt tgtctctctg
tttctgttct gactgagaac ctgcagccat ttcttgttac 5040atgaaaacaa
aatgctactt gttacctcta ttttttgtta ctatacaatt atgaaatgta
5100atgtaagaca ccaacagaaa tgatatacct gtaactgtac ctatcaggac
tatacctcat 5160ttacagtcag aaagcttact gggatgtcag gaaatgatac
agggttggtt ctcatttcgt 5220gccgaaatga gacagaaatt cagtgacgaa
ggtgcgttgt aggggtattg atgtgcccca 5280ggtagtgcca gcagagtagg
gaaaactgca tttgcataaa aactactctt gacatgattg 5340ttcattttac
aaaaaaattc cattaattac caagccctca cccagcccat gtgtgatagg
5400atttatgtag gaagaaactt gattttcaaa taatttttta aatgtatctc
ttgcctaaag 5460gactatatac atctaataaa gtaacactgt gtcatcttct
ggagttatca aaaattgtat 5520acaatcaaga caacacaaga attattttat
ttttgagtgc aaatacaggt actgttggag 5580ttgatgggca ccatgctttc
tcatgaagta gcatttccct accatcaagc cattgttttg 5640tgccattcag
gagaggaaaa aaaggaattt atgctgtaca tttcagttca gtgtatgacc
5700aaaagcaata tgtttataag aagatgtttg acatactaat tattttatat
catttaaacc 5760atactgtagc aacataatat atggagctaa tttgtagaat
tatttttacg atttccaaac 5820aaatgtactg tactgttata taatttattg
tgaggacctt ctcatggaag ccattaggaa 5880aacaaactag aggtaaatat
cacattaatc tgtattatca atttctcata gacactgtgc 5940taatgtgaat
tttaaatgac ctgcatcaag tcttctgatc tcagataact cagtacagat
6000agcaattagt cagctgattt gattacaatg gagtaaccga caatatattt
atttataaag 6060cacatattca taataacgag aagaattcag aaaaccactt
aagcaagacc cttctgaaat 6120aaaaaatgtt gctttttaaa tagtttgtcc
taaggtgttt aaaacatgtc aaccttatgt 6180aaggaaaaat ttcctggtcc
aaataaagtt gaagtttaag aaaaattg 622856095DNAHomo sapiens 5gcgccgtgcg
gcccgtgcga ctcgccggac ctcgcgggcg tccctgtacg gagccctcgg 60ccggtcctag
cagggattgt ccccatttcc agctccggag cgggcggctg cgccccgctc
120gtcgaggagc tgcgctcacc tcaggggcgg gcccccgcct gcgttcgcgg
cgccagcaga 180agactgattt ttggaaatat gtatttggga gacagtcacg
tcctattgaa taccttgtgc 240tggtgctgcc atcgaaaaat ctggttacac
tctggggagg actgctacca ctgcagaact 300gaaccacttc ggccgtgaga
tgagtgtccg gcctgagcag gcacaccatg aatagataca 360caacaatcag
gcagctcggg gatggaacct acggttccgt cctgctggga agaagcattg
420agtctgggga gctgatcgct attaaaaaaa tgaaaagaaa attttattcc
tgggaggaat 480gcatgaacct tcgggaggtt aagtctttaa agaagctcaa
ccatgccaat gtagtcaaat 540taaaagaagt tatcagggaa aatgatcatc
tttattttat cttcgagtac atgaaggaaa 600atctttacca gctcattaaa
gagagaaata agttgtttcc tgagtctgct ataaggaata 660tcatgtatca
gatattacaa ggactcgcat ttattcacaa acacggcttc tttcatcgag
720acttaaagcc tgagaacctc ctctgcatgg gaccagaact tgtgaaaatt
gcagactttg 780gtttggcccg agaaatacga tcaaaacctc catatacaga
ttatgtatct accagatggt 840acagggctcc agaagtactc ctgaggtcta
ccaactacag ctcccccatt gacgtctggg 900cggtgggctg catcatggca
gaagtttaca ccctcaggcc actcttccct ggagccagtg 960aaattgacac
aatattcaaa atttgccaag tgctggggac accaaaaaag actgactggc
1020ctgaaggcta tcaactttca agtgcaatga acttccgttg gccacagtgt
gtacccaata 1080acttaaagac cttgattccc aatgctagca gtgaagcagt
ccagctcctg agagacatgc 1140ttcagtggga tcccaagaaa cgaccaacag
ctagtcaggc acttcgatat ccttacttcc 1200aagttggaca cccactaggc
agcaccacac aaaaccttca ggattcagaa aaaccacaga 1260aaggcatcct
ggaaaaggca ggcccacctc cttatattaa gccagtccca cctgcccagc
1320caccagccaa gccacacaca cgaatttctt cacgacagca tcaagccagc
cagccccctc 1380tgcatctcac gtacccctac aaagcagagg tctccaggac
agatcaccca agccatctcc 1440aggaggacaa gccaagcccg ttgcttttcc
catccctcca caacaagcat ccacagtcga 1500aaatcacagc tggcctggag
cacaaaaatg gtgagataaa gccaaagagt aggagaaggt 1560ggggtcttat
ttccaggtca acaaaggatt cagatgattg ggctgacttg gatgacttgg
1620atttcagtcc atccctcagc aggattgacc tgaaaaacaa gaaaagacag
agtgatgaca 1680ctctctgcag gtttgagagt gttttggacc tgaagccctc
tgagcctgtg ggcacaggaa 1740acagtgcccc cacccagacg tcatatcagc
ggcgagacac gcccaccctg agatctgcag 1800ccaagcagca ctatttgaag
cactctcgat acttgcctgg gatcagtata agaaatggca 1860tactctcgaa
tccaggcaag gaatttattc cacctaatcc atggtctagt tctggcttgt
1920ctggaaaatc ttcagggaca atgtcagtaa tcagcaaagt aaattcagtt
ggttccagct 1980ctacaagttc tagtggactg actggaaact atgtcccttc
ctttctgaaa aaagaaatcg 2040gttctgctat gcagagggta cacctagcac
ctattccaga cccttcccct ggttattcct 2100ccctgaaggc catgagacct
catcctgggc gaccattctt ccacacccag cctagaagca 2160ctcctgggtt
gataccacgg cctccagccg cccagccagt gcatggccgg acagactggg
2220cttccaagta cgcatctcgg cgatgactgt ctgccttggt gatgaatctc
ttcctaggga 2280gaagcaggat actttccctc agctgactgg tgttctacct
gcaagatgtg cagagggcat 2340aaaagcaaat caacacttta tagttattct
tctgaactaa gacatgtcaa tattcttttt 2400taaagttttt ttttaaaata
ttgatttgaa tgcagtaggc ttttttgtat aaaattattt 2460tattctaaaa
ctgggtccca ttattttctt aaacaacagc attttgtata tatggattat
2520gttttagcat tttatacagt caactttgta atgaactttt taaaaattaa
ttgattttcc 2580tttggggttc cagataatat tttctacaga ttttgaaaaa
tgtaataata ttaatgcagt 2640attgcaacag gggtgcaatt taaggctatg
tgatagaggg ttatttactc agtgtgtgca 2700gatatttatg aagtggtgaa
atttcaagtg tggctcacta ggtacttcag gccttcttgg 2760actgttgtta
gaaaagtgat cctctgcttt tcttagtagg tcattggttt gatttttgga
2820taccactctg ctgttctaaa aggactatta tattatataa ttcactttgt
tttacttttg 2880ttccccagat gaaagaactc taagtaaata cattttaaaa
aatttttctg acacccttta 2940atgtggttgc agatctcaga tgaaaccaag
cttaattata ctatgccatt atattctaat 3000ttattccatt tttgaaatca
agttgtatgt gtaccaataa aagagatttc tgcttcaaaa 3060ggctctcaac
atgaaggtta acacagtcaa tcaaacttac attcctgcca agatgcatgg
3120ccaaaaaact aagtatcaaa gcagcagaag gtttttgatt atagtaactg
agatggaatt 3180ttgtgcctag ctcagttctc cagatctggc taggagcagt
caatgactaa tgttctgtcc 3240tagccaaatt ctcaggacaa tttggggagc
agaaagagtt atggcagagg ttccactcat 3300ctacaaagtc acagtcacat
gccacatttg atctcctaac cctggtgtag tttctttcaa 3360gagtgagaac
tttatttgtt gggcagaggc tgttccattg agaggaatgt ttacagcagt
3420ttcaaaaatg acaaagtcag tttggagaca gaaaaagaca aaaggtccag
tctcatccat 3480ctctatatgg tacatttgcc tcacttatgg ttgccttaaa
ggcaagaggg aaggtcacca 3540tcagtgaacg caatgcaatc tcaacagtgt
attgattcat attctcctag ggctcaaact 3600actctctatt ggttccagga
taatgacaaa ttgaaccata tgtaagtaat cttttatttt 3660ttattttttt
tttgagacag agtctcactc tgtcacccag gctggagtgc agtggcgcga
3720tcttagctct ctgcaacctc tgcctcccag gttcaagcct cctgagtaac
tgggactaca 3780ggcgcccgcc accacgccca gctaattttt tgtattttta
gtagagacgg ggtttcactg 3840tgttagccag gacggcctcg atctcctgac
ctcgtgatcc accctcctcc acctcccaaa 3900gtactgggat tacaggcatg
agccactgca cccagccaag tgatcatttt tataggttaa 3960aatgataggt
gaaatgaata tagacacttt catatggttc aacctaatga cttggtaaat
4020tattgccttg gtgtattaat aatatgttgc attctgaaca aataaccatg
gcttccaaag 4080ggccctaacc taaaatcgga gagtaattta tgctttggag
aatttgactc aaatatatac 4140ttgaccaagc accatgatcc ctaggggcat
gagaaaagca cataatggat gtggatgtga 4200taggtggtct tttcctgtta
acaagctggc agcaaagctt cagaaaatat atatgcaagc 4260acaacttgaa
gctgaattca tttctgtatt atattctcaa ctcgttatct aaagcatcag
4320aacatgtgtt ttcagagatg agtcctttac tataaggtta atatttattt
tcattttctg 4380tattatatat gaaaagtaaa ttaatgtgaa acctggccca
gcttgctgga aagcaggttt 4440taaattgtaa atattcctta gaggagcaaa
tggattgttt aataccatag tctcagtaat 4500ctagcttata taaggtcatt
acatttttta actgaaaaac ctagttacct gattattgca 4560cattataaaa
ttgtttttct aatactttat agggcccaac ttcagaaaat acttcgcttt
4620tttcttttta tgctttcgtt tgtttaccag caagcaactt ccctggggaa
gccaaacaca 4680tattcataaa aaaaatcaag tagctgatgt gcagttgaga
aaactagagg actgaaaaaa 4740caaattttaa ctagcaaatg ctgtgaatta
ctcttcctcc ccttctctga aatgggtaaa 4800ggacaaattg tgtaaaaaaa
cctatgcact atagaaggga atagtaacca tttcttttgt 4860ctctctgttt
ctgttctgac tgagaacctg cagccatttc ttgttacatg aaaacaaaat
4920gctacttgtt acctctattt tttgttacta tacaattatg aaatgtaatg
taagacacca 4980acagaaatga tatacctgta actgtaccta tcaggactat
acctcattta cagtcagaaa 5040gcttactggg atgtcaggaa atgatacagg
gttggttctc atttcgtgcc gaaatgagac 5100agaaattcag tgacgaaggt
gcgttgtagg ggtattgatg tgccccaggt agtgccagca 5160gagtagggaa
aactgcattt gcataaaaac tactcttgac atgattgttc attttacaaa
5220aaaattccat taattaccaa gccctcaccc agcccatgtg tgataggatt
tatgtaggaa 5280gaaacttgat tttcaaataa ttttttaaat gtatctcttg
cctaaaggac tatatacatc 5340taataaagta acactgtgtc atcttctgga
gttatcaaaa attgtataca atcaagacaa 5400cacaagaatt attttatttt
tgagtgcaaa tacaggtact gttggagttg atgggcacca 5460tgctttctca
tgaagtagca tttccctacc atcaagccat tgttttgtgc cattcaggag
5520aggaaaaaaa ggaatttatg ctgtacattt cagttcagtg tatgaccaaa
agcaatatgt 5580ttataagaag atgtttgaca tactaattat tttatatcat
ttaaaccata ctgtagcaac 5640ataatatatg gagctaattt gtagaattat
ttttacgatt tccaaacaaa tgtactgtac 5700tgttatataa tttattgtga
ggaccttctc atggaagcca ttaggaaaac aaactagagg 5760taaatatcac
attaatctgt attatcaatt tctcatagac actgtgctaa tgtgaatttt
5820aaatgacctg catcaagtct tctgatctca gataactcag tacagatagc
aattagtcag 5880ctgatttgat tacaatggag taaccgacaa tatatttatt
tataaagcac atattcataa 5940taacgagaag aattcagaaa accacttaag
caagaccctt ctgaaataaa aaatgttgct 6000ttttaaatag tttgtcctaa
ggtgtttaaa acatgtcaac cttatgtaag gaaaaatttc 6060ctggtccaaa
taaagttgaa gtttaagaaa aattg 609561368DNAHomo sapiens 6atgatctgct
gcagtgctct gagccctagg attcatcttt cttttcaccg tagcctgact 60ggcattgtat
tagcaaactc atcactagac atcgtactac acgacacgta ctacgttgta
120gcccactgcg ggggaaatgt taggcgcctg cattgcggtg gccccgcgtc
ccgggagcgc 180acagcaatgc aggcgcttaa cattaccccg gagcagttct
ctcggctgct gcgggaccac 240aacctgacgc gggagcagtt catcgctctg
taccggctgc gaccgctcgt ctacacccca 300gagctgccgg gacgcgccaa
gctggccctc gtgctcaccg gcgtgctcat cttcgccctg 360gcactctttg
gcaatgctct ggtgttctac gtggtgaccc gcagcaaggc catgcgcacc
420gtcaccaaca tctttatctg ctccttggcg ctcagtgacc tgctcatcac
cttcttctgc 480attcccgtca ccatgctcca gaacatttcc gacaactggc
tggggggtgc tttcatttgc 540aagatggtgc catttgtcca gtctaccgct
gttgtgacag aaatcctcac tatgacctgc 600attgctgtgg aaaggcacca
gggacttgtg catcctttta aaatgaagtg gcaatacacc 660aaccgaaggg
ctttcacaat gctaggtgtg gtctggctgg tggcagtcat cgtaggatca
720cccatgtggc acgtgcaaca acttgagatc aaatatgact tcctatatga
aaaggaacac 780atctgctgct tagaagagtg gaccagccct gtgcaccaga
agatctacac caccttcatc 840ctgtcatcct cttcctcctg cctcttatgg
aagaagaaac gagctgtcat tatgatggtg 900acagtggtgg ctctctttgc
tgtgtgctgg gcaccattcc atgttgtcca tatgatgatt 960gaatacagta
attttgaaaa ggaatatgat gatgtcacaa tcaagatgat ttttgctatc
1020gtgcaaatta ttggattttc caactccatc tgtaatccca ttgtctatgc
atttatgaat 1080gaaaacttca aaaaaaatgt tttgtctgca gtttgttatt
gcatagtaaa taaaaccttc 1140tctccagcac aaaggcatgg aaattcagga
attacaatga tgcggaagaa agcaaagttt 1200tccctcagag agaatccagt
ggaggaaacc aaaggagaag cattcagtga tggcaacatt 1260gaagtcaaat
tgtgtgaaca gacagaggag aagaaaaagc tcaaacgaca tcttgctctc
1320tttaggtctg aactggctga gaattctcct ttagacagtg ggcattaa
136871296DNAHomo sapiens 7atgcaggcgc ttaacattac cccggagcag
ttctctcggc tgctgcggga ccacaacctg 60acgcgggagc agttcatcgc agttcatcgc
ctgcgaccgc tcgtctacac cccagagctg 120ccgggacgcg ccaagctggc
cctcgtgctc accggcgtgc tcatcttcgc cctggcgctc 180tttggcaatg
ctctggtgtt ctacgtggtg acccgcagca aggccatgcg caccgtcacc
240aacatcttta tctgctcctt ggcgctcagt gacctgctca tcaccttctt
ctgcattccc 300gtcaccatgc tccagaacat ttccgacaac tggctggggg
gtgctttcat ttgcaagatg 360gtgccatttg tccagtctac cgctgttgtg
acagaaatcc tcactatgac ctgcattgct 420gtggaaaggc accagggact
tgtgcatcct tttaaaatga agtggcaata caccaaccga 480agggctttca
caatgctagg tgtggtctgg ctggtggcag tcatcgtagg atcacccatg
540tggcacgtgc aacaacttga gatcaaatat gacttcctat atgaaaagga
acacatctgc 600tgcttagaag agtggaccag ccctgtgcac cagaagatct
acaccacctt catccttgtc 660atcctcttcc tcctgcctct tatggtgatg
cttattctgt acagtaaaat tggttatgaa 720ctttggataa agaaaagagt
tggggatggt tcagtgcttc gaactattca tggaaaagaa 780atgtccaaaa
tagccaggaa gaagaaacga gctgtcatta tgatggtgac agtggtggct
840ctctttgctg tgtgctgggc accattccat gttgtccata tgatgattga
atacagtaat 900tttgaaaagg aatatgatga tgtcacaatc aagatgattt
ttgctatcgt gcaaattatt 960ggattttcca actccatctg taatcccatt
gtctatgcat ttatgaatga aaacttcaaa 1020aaaaatgttt tgtctgcagt
ttgttattgc atagtaaata aaaccttctc tccagcacaa 1080aggcatggaa
attcaggaat tacaatgatg cggaagaaag caaagttttc cctcagagag
1140aatccagtgg aggaaaccaa aggagaagca ttcagtgatg gcaacattga
agtcaaattg 1200tgtgaacaga cagaggagaa gaaaaagctc aaacgacatc
ttgctctctt taggtctgaa 1260ctggctgaga attctccttt agacagtggg cattaa
129684350DNAHomo sapiens 8agttgaggga ttgacacaaa tggtcaggcg
gcggcggcgg agaaggaggc ggaggcgcag 60gggggagccg agcccgctgg gctgcggaga
gttgcgctct ctacggggcc gcggccacta 120gcgcggcgcc gccagccggg
agccagcgag ccgagggcca ggaaggcggg acacgacccc 180ggcgcgccct
agccacccgg gttctccccg ccgcccgcgc ttcatgaatc gcaagtttcc
240gcggcggcgg cggctgcggt acgcagaaca ggagccgggg gagcgggccg
aaagcggctt 300gggctcgacg gagggcaccc gcgcagaggt ctccctggcc
gcagggggag ccgccgccgg 360ccgtgcccct ggcagcccca gcggagcggc
gccaagagag gagccgagaa agtatggctg 420aggaggaggc gcctaagaag
tcccgggccg ccggcggtgg cgcgagctgg gaactttgtg 480ccggggcgct
ctcggcccgg ctggcggagg agggcagcgg ggacgccggt ggccgccgcc
540gcccgccagt tgacccccgg cgattggcgc gccagctgct gctgctgctt
tggctgctgg 600aggctccgct gctgctgggg gtccgggccc aggcggcggg
ccaggggcca ggccaggggc 660ccgggccggg gcagcaaccg ccgccgccgc
ctcagcagca acagagcggg cagcagtaca 720acggcgagcg gggcatctcc
gtcccggacc acggctattg ccagcccatc tccatcccgc 780tgtgcacgga
catcgcgtac aaccagacca tcatgcccaa cctgctgggc cacacgaacc
840aggaggacgc gggcctggag gtgcaccagt tctaccctct agtgaaagtg
cagtgttccg 900ctgagctcaa gttcttcctg tgctccatgt acgcgcccgt
gtgcaccgtg ctagagcagg 960cgctgccgcc ctgccgctcc ctgtgcgagc
gcgcgcgcca gggctgcgag gcgctcatga 1020acaagttcgg cttccagtgg
ccagacacgc tcaagtgtga gaagttcccg gtgcacggcg 1080ccggcgagct
gtgcgtgggc cagaacacgt ccgacaaggg caccccgacg ccctcgctgc
1140ttccagagtt ctggaccagc aaccctcagc acggcggcgg agggcaccgt
ggcggcttcc 1200cggggggcgc cggcgcgtcg gagcgaggca agttctcctg
cccgcgcgcc ctcaaggtgc 1260cctcctacct caactaccac ttcctggggg
agaaggactg cggcgcacct tgtgagccga 1320ccaaggtgta tgggctcatg
tacttcgggc ccgaggagct gcgcttctcg cgcacctgga 1380ttggcatttg
gtcagtgctg tgctgcgcct ccacgctctt cacggtgctt acgtacctgg
1440tggacatgcg gcgcttcagc tacccggagc ggcccatcat cttcttgtcc
ggctgttaca 1500cggccgtggc cgtggcctac atcgccggct tcctcctgga
agaccgagtg gtgtgtaatg 1560acaagttcgc cgaggacggg gcacgcactg
tggcgcaggg caccaagaag gagggctgca 1620ccatcctctt catgatgctc
tacttcttca gcatggccag ctccatctgg tgggtgatcc 1680tgtcgctcac
ctggttcctg gcggctggca tgaagtgggg ccacgaggcc atcgaagcca
1740actcacagta ttttcacctg gccgcctggg ctgtgccggc catcaagacc
atcaccatcc 1800tggcgctggg ccaggtggac ggcgatgtgc tgagcggagt
gtgcttcgtg gggcttaaca 1860acgtggacgc gctgcgtggc ttcgtgctgg
cgcccctctt cgtgtacctg tttatcggca 1920cgtcctttct gctggccggc
tttgtgtcgc tcttccgcat ccgcaccatc atgaagcacg 1980atggcaccaa
gaccgagaag ctggagaagc tcatggtgcg cattggcgtc ttcagcgtgc
2040tgtacactgt gccagccacc atcgtcatcg cctgctactt ctacgagcag
gccttccggg 2100accagtggga acgcagctgg gtggcccaga gctgcaagag
ctacgctatc ccctgccctc 2160acctccaggc gggcggaggc gccccgccgc
acccgcccat gagcccggac ttcacggtct 2220tcatgattaa gtaccttatg
acgctgatcg tgggcatcac gtcgggcttc tggatctggt 2280ccggcaagac
cctcaactcc tggaggaagt tctacacgag gctcaccaac agcaaacaag
2340gggagactac agtctgagac ccggggctca gcccatgccc aggcctcggc
cggggcgcag 2400cgatccccca aagccagcgc cgtggagttc gtgccaatcc
tgacatctcg aggtttcctc 2460actagacaac tctctttcgc aggctccttt
gaacaactca gctcctgcaa aagcttccgt 2520ccctgaggca aaaggacacg
agggcccgac tgccagaggg aggatggaca gacctcttgc 2580cctcacactc
tggtaccagg actgttcgct tttatgattg taaatagcct gtgtaagatt
2640tttgtaagta tatttgtatt taaatgacga ccgatcacgc gtttttcttt
ttcaaaagtt 2700tttaattatt tagggcggtt taaccatttg aggcttttcc
ttcttgccct tttcggagta 2760ttgcaaagga gctaaaactg gtgtgcaacc
gcacagcgct cctggtcgtc ctcgcgcgcc 2820tctccctacc acgggtgctc
gggacggctg ggcgccagct ccggggcgag ttcagcactg 2880cggggtgcga
ctagggctgc gctgccaggg tcacttcccg cctcctcctt ttgccccctc
2940cccctccttc tgtcccctcc ctttctttcc tggcttgagg taggggctct
taaggtacag 3000aactccacaa accttccaaa tctggaggag ggcccccata
cattacaatt cctcccttgc 3060tcggcggtgg attgcgaagg cccgtccctt
cgacttcctg aagctggatt tttaactgtc 3120cagaactttc ctccaacttc
atgggggccc acgggtgtgg gcgctggcag tctcagcctc 3180cctccacggt
caccttcaac gcccagacac tcccttctcc caccttagtt ggttacaggg
3240tgagtgagat aaccaatgcc aaactttttg aagtctaatt tttgaggggt
gagctcattt 3300cattctctag tgtctaaaac ctggtatggg tttggccagc
gtcatggaaa gatgtggtta 3360ctgagatttg ggaagaagca tgaagctttg
tgtgggttgg aagagactga agatatgggt 3420tataaaatgt taattctaat
tgcatacgga tgcctggcaa ccttgccttt gagaatgaga 3480cagcctgcgc
ttagatttta ccggtctgta aaatggaaat gttgaggtca cctggaaagc
3540tttgttaagg agttgatgtt tgctttcctt aacaagacag caaaacgtaa
acagaaattg 3600aaaacttgaa ggatatttca gtgtcatgga cttcctcaaa
atgaagtgct attttcttat 3660ttttaatcaa ataactagac atatatcaga
aactttaaaa tgtaaaagtt gtacactttc 3720aacattttat tacgattatt
attcagcagc acattctgag gggggaacaa ttcacaccac 3780caataataac
ctggtaagat ttcaggaggt aaagaaggtg gaataattga cggggagata
3840gcgcctgaaa taaacaaaat atgggcatgc atgctaaagg gaaaatgtgt
gcaggtctac 3900tgcattaaat cctgtgtgct cctcttttgg atttacagaa
atgtgtcaaa tgtaaatctt 3960tcaaagccat ttaaaaatat tcactttagt
tctctgtgaa gaagaggaga aaagcaatcc 4020tcctgattgt attgttttaa
actttaagaa tttatcaaaa tgccggtact taggacctaa 4080atttatctat
gtctgtcata cgctaaaatg atattggtct ttgaatttgg tatacattta
4140ttctgttcac tatcacaaaa tcatctatat ttatagagga atagaagttt
atatatatat 4200aataccatat ttttaatttc
acaaataaaa aattcaaagt tttgtacaaa attatatgga 4260ttttgtgcct
gaaaataata gagcttgagc tgtctgaact attttacatt ttatggtgtc
4320tcatagccaa tcccacagtg taaaaattca 43509952DNAHomo sapiens
9ttggtccaag caagaaggca gtggtctact ccatcggcaa catgctggtc ctttatggac
60acagcaccca ggaccttccg gaaaccaatg cccgcgtagt cggagggact gaggccggga
120ggaattcctg gccctctcag atttccctcc agtaccggtc tggaggttcc
cggtatcaca 180cctgtggagg gacccttatc agacagaact gggtgatgac
agctgctcac tgcgtggatt 240accagaagac tttccgcgtg gtggctggag
accataacct gagccagaat gatggcactg 300agcagtacgt gagtgtgcag
aagatcgtgg tgcatccata ctggaacagc gataacgtgg 360ctgccggcta
tgacatcgcc ctgctgcgcc tggcccagag cgttaccctc aatagctatg
420tccagctggg tgttctgccc caggagggag ccatcctggc taacaacagt
ccctgctaca 480tcacaggctg gggcaagacc aagaccaatg ggcagctggc
ccagaccctg cagcaggctt 540acctgccctc tgtggactac gccatctgct
ccagctcctc ctactggggc tccactgtga 600agaacaccat ggtgtgtgct
ggtggagatg gagttcgctc tggatgccag ggtgactctg 660ggggccccct
ccattgcttg gtgaatggca agtattctgt ccatggagtg accagctttg
720tgtccagccg gggctgtaat gtctccagga agcctacagt cttcacccag
gtctctgctt 780acatctcctg gataaataat gtcatcgcct ccaactgaac
attttcctga gtccaacgac 840cttcccaaaa tggttcttag atctgcaata
ggacttgcga tcaaaaagta aaacacattc 900tgaaagacta ttgagccatt
gatagaaaag caaataaaac tagatataca tt 952109372DNAHomo sapiens
10tgaataattg aactttgttt atttctccat atttttgcag tggtaattcc attataaaac
60ctaatgaaac aatgttttta tagatggtgt ggaaagactt ttctgggctc agaggtgaaa
120ctgacccttg tgtatcagca gcatttctga ctgactgaga gagtgtagtg
attaacagag 180ttgtgatgtt agttaagaaa cttagatttg ccattgtagc
ttttctacca attagcagat 240tgtttaactc actgaaattg taaagtggta
gacgtggact tagtcattac tgggcagctt 300atgaattgta ttcatttact
catgatgtaa aaatggttag tctccacttt taaggctcta 360gttctagtgg
ctaaataggt acttatttat acagtatgat aactgctgta ttaaaataca
420tgtctcaaat gtggaatagt agaagaggtg aagaaaatca tagtttgagg
tagaatactg 480tttgctggtc ttaaaaactg tggtattttg gtgattccat
aaattaggtc agatacttcc 540actggaggga aacagtttaa aggatatatg
tgatactatt aatagaatga ggaagacaca 600ccagatattt aggagggaat
tagcgagctt gaaactaaga gctggtttga atgagactgg 660gtcataagtg
atttcaagta ccagattaag gcactgagat tttattttta agcactgaag
720tcagattttt tccttttaaa agaaaggatt catgatgaaa tctgcttttt
gttttgcaga 780gagcttggag ataattctgg tggctgtgtg gagtatgtgt
tggaggtatt aaattttcac 840agtatatata aggcagcaat tgataggcct
ttcacagatt cttctgataa ctacataaag 900agacaaaaaa aagaaaaaag
agcaaagatc tgtgctgtgt caagtatgac agccatcact 960catggctctc
cagtaggagg gaacgacagc cagggccagg ttcttgatgg ccagtctcag
1020catctcttcc aacagaacca gacttcatca cctgattctt ccaatgagaa
ttccgtagca 1080actcctcctc cagaggaaca agggcaaggt gatgccccac
cacagcatga agatgaagag 1140cctgcatttc cacatactga gctggcaaac
ctggatgaca tgatcaacag gcctcgatgg 1200gtggttcctg ttttgccaaa
aggggaatta gaagtgcttt tagaagctgc tattgatctt 1260agtgtaaaag
gccttgatgt taaaagtgaa gcatgccaac gtttttttcg agatggacta
1320acaatatctt tcactaaaat tcttatggat gaggctgtga gtggctggaa
gtttgaaatt 1380catagatgta ttattaacaa tactcatcgc ctagtggagc
tttgtgtggc caagttgtcc 1440caagattggt ttccacttct agaacttctc
gccatggcct taaatcctca ctgcaagttt 1500catatctaca atggtacacg
tccgtgtgaa ttaatttcct caaatgctca gttgcctgaa 1560gaagaattat
ttgctcgttc ttcagatcct cgatcaccaa aaggttggct agtggatctc
1620atcaataaat ttggcacatt aaatgggttc cagattttgc atgatcgttt
ttttaatgga 1680tcagcattaa atattcaaat aattgcagct cttattaaac
catttggaca atgctatgag 1740tttctcagtc aacatacact gaaaaagtac
ttcattccag ttatagaaat agttccacat 1800ttattggaaa acttaactga
tgaagaactg aaaaaggagg caaagaatga agccaaaaat 1860gatgcccttt
caatgattat taaatctttg aagaacttag cttcaagaat ttcaggacaa
1920gatgagacta taaaaaattt ggaaattttt aggttaaaga tgatactcag
attgttgcaa 1980atttcctctt ttaatggaaa gatgaatgca ctgaatgaaa
taaataaggt tatatctagt 2040gtatcatatt atactcatcg gcatagtaat
cctgaggagg aagaatggct gacagctgag 2100cgaatggcag aatggataca
gcaaaataat atcttatcca tagtcttgca agacagtctt 2160catcaaccac
aatatgtaga aaagctagag aaaattcttc gttttgtgat taaagaaaag
2220gctcttacat tacaggacct tgataatatc tgggcagcac aggcaggaaa
acatgaagcc 2280attgtgaaga atgtacatga tctgctagca aagttggctt
gggatttttc tcctggacaa 2340cttgatcatc tttttgattg ctttaaggca
agttggacaa atgcaagtaa aaagcaacgt 2400gaaaagctcc ttgagttgat
acgccgtctt gcagaagatg ataaagatgg tgtgatggca 2460cacaaagtgt
tgaaccttct ttggaacctg gctcagagtg atgatgtgcc tgtagacatc
2520atggaccttg ctcttagtgc ccacataaaa atactagatt atagttgttc
ccaggatcga 2580gatgcacaga agatccagtg gatagatcac tttatagaag
aacttcgcac aaatgacaag 2640tgggtaattc ctgctctgaa acaaataaga
gaaatttgta gtttgtttgg tgaagcatct 2700caaaatttga gtcaaactca
gcgaagtccc cacatatttt atcgccatga tttaatcaac 2760cagcttcaac
aaaatcatgc tttagttact ttggtagcag aaaaccttgc aacctacatg
2820aatagcatca gattgtatgc tggagatcat gaagactatg atccacaaac
agtgaggctt 2880ggaagtcgat acagtcatgt tcaagaagtt caagaacgac
taaacttcct tagattttta 2940ctgaaggatg gccaactgtg gctctgtgct
cctcaggcaa aacaaatatg gaagtgctta 3000gcagaaaatg cagtttatct
ttgtgatcgt gaagcctgtt ttaagtggta ttccaagtta 3060atgggggatg
aaccagactt ggatcctgat attaataagg acttctttga aagtaatgta
3120cttcagcttg atccttccct tttaactgaa aatggaatga aatgctttga
aagatttttc 3180aaagctgtca attgtcgaga aaggaaacta atagcaaaaa
gaagatccta tatgatggat 3240gatttggaat taattggact agactacctt
tggagggttg tgattcagag tagtgacgag 3300attgctaaca gagctataga
tcttcttaaa gagatataca caaaccttgg cccaagatta 3360aaagccaatc
aggtggttat ccatgaagac ttcattcagt cttgctttga tcgtttaaaa
3420gcatcatatg atacactgtg tgtttttgat ggtgacaaaa acagcattaa
ttgtgcaaga 3480caagaagcca ttcgaatggt tagagtatta actgttataa
aagagtacat taatgaatgt 3540gacagtgatt atcacaagga aagaatgatt
ttacctatgt cgagagcatt ttgtggcaaa 3600cacctctctc ttatagttcg
gtttccaaac cagggcagac aggttgatga gttggatata 3660tggtttcata
cgaatgacac aattggttca gtacggcgat gtattgttaa tcgtattaaa
3720gccaatgtag cccacaaaaa aattgaactt tttgtgggtg gtgagctgat
agattctgaa 3780aatgacagaa agctaattgg acaattaaac ttaaaagata
aatctctaat tacagccaaa 3840cttacacaaa taaatttcaa tatgccatca
agtcctgata gctcttccga ttcctcaact 3900gcatctcctg gaaaccaccg
taatcattac aatgatggtc ccaatctaaa ggtggaaagt 3960tgtttgcctg
gggtgataat gtcagtgcat cccaaataca tctctttcct ttggcaattt
4020gcaaacttag gtagcaacct gaatatgcca cctcttaaaa atggagcaag
agtacttatg 4080aaacttatgc caccagatag aacagctgta gaaaaattac
gaactgtttg tttggaccat 4140gcaaaccttg gagaaggcaa acttagtcca
ccccttgact cccttttctt tggtccttct 4200gcctcccaag ttctatacct
aacagaggta gtttatgcct tgttaatgcc tgctggtgtg 4260cctctaactg
atgggtcctc tgactttcaa gttcacttct tgaaaagtgg tggcttacct
4320cttgtactga gtatgctaat aagaaataac ttcttgccaa atacagatat
ggaaactcga 4380aggggtgctt atttaaatgc tcttaaaata gccaaactgt
tgttaactgc gattggctat 4440ggccatgttc gagctgtagc agaagcttgt
cagccagttg tagatggtac agaccccata 4500acacagatta accaagttac
tcatgatcaa gcagtggtgc tacaaagtgc ccttcagagc 4560attcctaatc
cctcatccga gtgcgtactt agaaatgagt ccatacttct tgctcaggaa
4620atatctaatg aggcttcaag atatatgcct gatatttgtg taattagggc
tatacagaaa 4680attatctggg catcagcatg tggggcatta ggactatttt
ttagcccaaa tgaagaaata 4740actaaaattt atcagatgac caccaatgga
agcaataagc tggaggtgga agatgaacaa 4800gtttgttgtg aagcactgga
agtgatgacc ttatgttttg ctttacttcc aacagcgttg 4860gatgcactta
gtaaagaaaa agcctggcag accttcatca ttgacttatt attgcactgt
4920ccaagcaaaa ctgttcgtca gttggcacag gagcagttct ttttaatgtg
caccagatgt 4980tgcatgggac acaggcctct gcttttcttc attactttac
tctttaccat actggggagc 5040acagcaagag agaagggtaa atattcaggt
gattatttca cacttttacg gcaccttctc 5100aattatgctt acaatggcaa
tattaacata cccaatgctg aagttcttct tgtcagtgaa 5160attgattggc
tcaaaaggat tagggataat gttaaaaaca caggtgaaac aggtgtcgaa
5220gagccaatac tggaaggcca ccttggggta acaaaagagt tattggcctt
tcaaacttct 5280gagaaaaagt atcactttgg ttgtgaaaaa ggaggtgcta
atctcattaa agaattaatt 5340gatgatttca tctttcccgc atccaaagtt
tacctgcagt atttaagaag tggagaacta 5400ccagctgagc aggctattcc
agtctgtagt tcacccgtta ccatcaatgc cggttttgag 5460ctacttgtag
cattagctat tggctgtgtg aggaatctca aacagatagt agactgtttg
5520actgaaatgt attacatggg cacagcaatt actacttgtg aagcacttac
tgagtgggaa 5580tatctgcccc ctgttggacc ccgcccacca aaaggatttg
tgggactcaa aaatgctggt 5640gctacgtgtt acatgaactc tgtgatccag
cagctataca tgattccttc tatcaggaac 5700agtattcttg caattgaagg
cacaggtagt gatttacacg atgatatgtt cggggatgag 5760aagcaggaca
gtgagagtaa tgttgatccc cgagatgatg tatttggata tcctcatcaa
5820tttgaagaca agccagcatt aagtaagaca gaagatagga aagagtataa
tattggtgtc 5880ctaagacacc ttcaggtcat ctttggtcat ttagctgctt
cccaactaca atactatgta 5940cccagaggat tttggaaaca gttcaggctt
tggggtgaac ctgttaatct ccgtgaacaa 6000catgatgcct tagagttttt
taattctttg gtggatagtt tagatgaagc tttaaaagct 6060ttaggacacc
cggctatact aagtaaagtc ctaggaggct cctttgctga tcagaagatc
6120tgccagggct gcccacatag gtttgaatgt gaagaatctt ttacaacttt
gaatgtggat 6180attagaaatc atcaaaatct tcttgactct ttggaacagt
atatcaaagg agatttattg 6240gaaggtgcaa atgcatatca ttgtgaaaaa
tgtgataaaa aggttgacac agtaaagcgc 6300ctgctaatta aaaaattgcc
tcgggttctt gctatccaac tcaaacgatt tgactatgac 6360tgggaaagag
aatgtgcaat taaattcaat gattattttg aatttcctcg agagctggat
6420atgggacctt acacagtagc aggtgttgca aacctggaaa gggataatgt
aaactcagaa 6480aatgagttga ttgaacagaa agagcagtct gacaatgaaa
ctgcaggagg cacaaagtac 6540agacttgtag gagtgcttgt acacagtggt
caagcaagcg gtgggcatta ttattcttac 6600atcattcaaa ggaatggtaa
agatgatcag acagatcact ggtataaatt tgatgatgga 6660gatgtaacag
aatgcaaaat ggatgatgat gaagaaatga aaaatcagtg ttttggtgga
6720gagtacatgg gagaagtatt tgatcacatg atgaagcgca tgtcatatag
gcgacagaag 6780aggtggtgga atgcttacat acctttttat gaacaaatgg
atatgataga tgaagatgat 6840gagatgataa gatacatatc agagctaact
attgcaagac cccatcagat cattatgtca 6900ccagccattg agagaagtgt
acggaaacaa aatgtgaaat ttatgcataa ccgattgcaa 6960tatagtttag
agtattttca gtttgtgaaa aaactgctta catgtaatgg tgtttattta
7020aaccctgctc cagggcagga ttatttgttg cctgaagcag aagaaattac
tatgattagt 7080attcagcttg ctgctagatt cctctttacc actggatttc
acaccaagaa aatagttcgt 7140ggtcctgcca gtgactggta tgatgcactg
tgcgttcttc tccgtcacag caaaaatgta 7200cgtttttggt ttactcataa
tgtccttttt aatgtatcaa atcgcttctc tgaatacctc 7260ctggagtgcc
ctagtgcaga agtgaggggt gcatttgcaa aacttatagt gtttattgca
7320cacttttcct tgcaagatgg gtcttgtcct tctccttttg catctccagg
accttctagt 7380caggcatgtg ataacttgag cttgagtgac cacttactaa
gagccacact aaatctcttg 7440agaagggaag tttcagagca tggacatcat
ttacagcaat attttaattt gtttgtaatg 7500tatgccaatt taggtgtggc
agaaaaaaca cagcttctga aattgaatgt acctgctacc 7560tttatgcttg
tgtctttaga cgagggacca ggtcctccaa tcaaatatca gtatgctgaa
7620ttaggcaagt tatattcagt agtgtctcag ctgattcgtt gttgcaatgt
gtcatcaaca 7680atgcagtctt caatcaatgg taatccccct ctccccaatc
ctttcggtga ccttaattta 7740tcacagccta taatgccaat tcagcagaat
gtgttagaca ttttatttgt gagaacaagt 7800tatgtgaaga aaattattga
agactgcagt aactcagagg ataccatcaa attacttcgc 7860ttttgctctt
gggagaatcc tcagttctca tctactgtcc tcagcgaact tctctggcag
7920gttgcatatt catataccta tgaacttcgg ccatatttag atctactttt
ccaaatttta 7980ctgattgagg actcctggca gactcacaga attcataatg
cacttaaagg aattccagat 8040gacagagatg ggctgttcga tacaatacag
cgctcgaaga atcactatca aaaacgagca 8100tatcagtgca taaaatgtat
ggtagctcta tttagcagtt gtcctgttgc ttaccagatc 8160ttacagggta
acggagatct taaaagaaaa tggacctggg cagtggaatg gctaggagat
8220gaacttgaaa gaagaccata tactggcaat cctcagtata gttacaacaa
ttggtctcct 8280ccagtacaaa gcaatgaaac agcaaatggt tatttcttag
aaagatcaca tagtgctagg 8340atgacacttg caaaagcttg tgaactctgt
ccagaagagg agccagatga ccaggatgcc 8400ccagatgagc atgagccctc
tccatcagaa gatgccccat tatatcctca ttcacctgcc 8460tctcagtatc
aacagaataa tcatgtacat ggacagccat atacaggacc agcagcacat
8520cacttgaaca accctcagaa aacaggccaa cgaacacaag aaaattatga
aggcaatgaa 8580gaagtatcct cacctcagat gaaggatcag tgaaaagcaa
taattaactg cttcctttat 8640gactatgcac taaggtctta tagtccaaac
tttctctgtg tctggctagt attgaaaact 8700agataaactg ctccaaacca
acatggagta aagagcatat tcactggttt atttgcagta 8760atttgcaatt
tgtcagtgta taagacacat gcagggtgaa gtgtacagag ttttgtaaca
8820aatgactggt cctaatctgt aaatgagaaa ggtatatata ctatgttaat
gtctgactgt 8880taattcttaa gcaagaaact ttttttgatg aaaacaagtc
agatctacac agtcacacaa 8940ttattttttg ttgtgttcac tacattgtgc
aattgatatt gcctgctttg agcagtttgg 9000tcaacttacc aacttccccc
caaaaaaggg aacataaaag agcccatctt tgtcagttta 9060caccaatagt
ttcttgttaa tccttctttc ctggatatat aaggctggtg gtaacttttg
9120aattatatgg ttgatgtgga aaattggcag tgtaacattt ctagatactt
ttcattacct 9180ttttattctg gtatataggc taaccacttt aaagctattc
ttatgctgta acagttagca 9240tggcttcaca ctgtttgtgt agccaagagg
acagaattac atgaatgaca gtgcccagag 9300tgacagctgt atattgctca
gagcttttat ttcttatacc tagaataaat ataaaatggg 9360ggaaaaaaaa aa
9372111593DNAHomo sapiens 11ctgggagcgc ggcgtaggtg gctgccgagt
cttttcctgt ttagggtctt atcctggcat 60tgagggcgcc ggactggcgc ttttggccgg
cttggcattg ggtgggcggc ttcttgggac 120ccacatgagc cagtggcatc
atccccgcag tggctggggc cggagacgcg acttttcagg 180acgctcctca
gccaagaaga agggcggaaa ccacatcccc gaaaggtgga aagactatct
240cccagttgga cagcggatgc ctgggactcg tttcattgct ttcaaagttc
ctttgcaaaa 300gagttttgaa aagaaacttg ctccagaaga atgcttttcc
cctttggatc tttttaacaa 360aatccgagaa caaaatgaag aacttggact
gattattgat ttaacatata ctcaacgcta 420ttataaacca gaggatttgc
cagaaactgt tccttactta aaaattttta cagttggaca 480tcaagtgcct
gatgatgaga ctatttttaa attcaaacac gctgttaatg ggtttttgaa
540agaaaataaa gataatgata aacttattgg tgtccactgt acccatggtt
taaacaggac 600tggctacctc atttgcagat atttgattga tgtagaaggc
gtgaggccag atgatgcaat 660tgaattattc aataggtgcc ggggacattg
cttagaaaga caaaactaca ttgaagacct 720tcagaatggt cctatcagaa
agaattggaa ttccagtgta cccaggtcaa gtgattttga 780agactcagca
catctcatgc aaccagtcca caataagcct gttaaacaag gacctaggta
840taatctacat cagatccagg gtcactcagc tcctcgacat ttccacaccc
agacccaaag 900tttgcaacaa tcagtcagaa aattttcaga gaatccacat
gtttaccaga gacaccatct 960ccctcctcct ggtccccctg gagaggacta
ttcacacagg aggtattctt ggaatgtgaa 1020gcccaatgcc agtcgggcag
cccaggatag aagaaggtgg tatccttata attactccag 1080actctcctat
ccagcctgtt gggaatggac ccagtgatac aaacctgtcc tggaattcta
1140cctggagacc agagctggcc tgaaaattac tggtgtgact tttaattagt
tcaggtctaa 1200tcaggtttct ttattgttcc cttatgtatt caagcttaag
gaaaaattgc attgctgttt 1260acctctttgc tgataaattt gcagtaatta
cagcattgca ggaaaaacaa tctgttattc 1320cagtcttaaa tttttctaaa
agaagacaat attttagaac tgaagcattg agaacttccc 1380ttgcaaatta
tttttaaaat tctatcttgt ttttctatgt atttctttct gactagactt
1440gtgatatgcg tgtgtttatg tacagaaatt tttagtgttt ttgttatgtt
ctgttattga 1500cccaaaggcc atctttattt tctataactg ttcaaaattt
atattaaaat ctacttagga 1560gataatttct ttagaaaaaa aaaaaaaaaa aaa
1593124116DNAHomo sapiens 12cgccgctctc cgcctcgctt gctcctgccg
ggcgtgcagg gccccgccgc cgccatgtcg 60ggctcgttcg agctctcggt gcaggatctc
aacgacctgc tctcggacgg cagcggctgc 120tacagcctcc cgagccagcc
ctgcaacgag gtcaccccgc ggatctacgt gggcaacgcg 180tctgtggctc
aggacatccc caagctgcag aaactaggca tcacccatgt gctgaacgcg
240gctgagggca ggtccttcat gcacgtcaac accaatgcca acttctacaa
ggactccggc 300atcacatacc tgggcatcaa ggccaacgac acacaggagt
tcaacctcag cgcttacttt 360gaaagggctg ccgacttcat tgaccaggct
ttggctcaaa agaatggccg ggtgctcgtc 420cactgccggg aaggttatag
ccgctcccca acgctagtta tcgcctacct catgatgcgg 480cagaagatgg
acgtcaagtc tgccctgagc atcgtgaggc agaaccgtga gatcggcccc
540aacgatggct tcctggccca gctctgccag ctcaatgaca gactagccaa
ggaggggaag 600ttgaaaccct agggcacccc caccgcctct gctcgagagg
tccgtggggg aggccgtggg 660caaaggtgtc ccgagctgcc atgtttagga
aacacactgt accctgctcc cagcatcaca 720aggcacttgt ctacaagtgt
gtcccaacac agtcctgggc cactttcccc accctgggga 780gcacataaag
aagcttgcca aggggggcgt ccttgctccc cagttgtcct gtttctgtaa
840cttatgatgt cttttccctg agatgggggc tcagaggggg aaggcctgtg
gcctgcatgc 900ttcccgatgg cccacggcag gaggtgtgtg gaagtgtaag
gcctaagatg ctcacagagg 960tccctcatga cctcccttcc ccaactcccg
aatcctctct tgagtgtgga cctcaacacc 1020ttgagcccta gtaaaggaac
tatgcaaatg caggccactc tccccaccac gtctgtgccc 1080cgcactgtcc
ccacagcctt ccacaccctg tgcataggca gccctctcac gtcttgaggt
1140ccgaagctgg ggtgggggtg tccgtcagtt attagtggat ggagattccc
acagcaaggc 1200tgcatttgaa tgatttcctt aggatgaatg gtccctacac
aaagaggcct tgtgggcaaa 1260cctggagaac cctcctaaat ccatagagtt
ttcaaaatgt gaatctttgg aagccttgag 1320ttcagaatct gctgctctgg
aatatttccc ttcgatctta tctcagtcac ttcgtttttg 1380agaagagtga
tgccttgggc atgctttttt ttttttcttt tttagaaaac agggagttga
1440agtccaacct atttaaaaac cccaccattt ggagaattac aagggttttg
tcctgaattg 1500tagtgttggc aagcccaagc cactcgtgct aactgctttt
tgtctcggtt gctattccaa 1560gaacagaagg aggaagttgg ccaattacag
cgtgtgtgca tggatgtgtg tggggggcgt 1620gcctctcaga aacgcggcca
gaagacaagc agggaagtga aaggtcccag gcacacaccc 1680tgcccattgc
aggtggctct tacagctctc tggtgccagc acgggatccc tgaagtgact
1740cagccaggca gacatgagac atggcggagt gtccaaatgg atcctttatt
ggtggtagag 1800caaaaaaacc caaacacgat aaacctttca aaagactttc
taaggatgat attggaatgc 1860accagccctc acatgtgtat gcacatttgc
cagaatataa gagttttgtt ttaaatacag 1920tcttgttagg attttacgtt
attgttatta tggaaagtga ttgtgatgct atttatcttc 1980agggtcactc
tgggcaaaga gaaggtcctc agccatgccc ccagcacctt gcacataggt
2040gtctgataaa agtttaagaa attaaacact ttttgagcac caaatatata
tagggcattg 2100ttctggtggg tgtgtcacgc tcccagaaga ctgaatttat
ggtaggatca ctcgcaaggc 2160cttgtgaagg agtcttacct aaaacaaaag
aaatatcagg gacttttgtt gactatttac 2220aactcagttt tacatttaaa
ttcaggcagt gttaatatgc caaggtaggg aatgtgcctt 2280tttcagagtt
ggccaggagc tcctggctgg gacacggaga ggcaggtgtg gcgtaaggcc
2340tcactcccgg ctgtgaaggt ctctgatcac acagaagcag ccctgcccag
cctggtcatt 2400tgctgtccgc ttttctctgt gaccacagca gccctgaaca
accagtatgt gtcttcttct 2460ccagatagtg aaaaaggtgt ccagataaac
ccacctaagt gaaatggcca tcctctaaac 2520tgggtacctc actgcacagc
ttctaggtag ccttccaact taatctaact tgagcctcac 2580agtaaccctg
taaagttagt agagcttgtt cttgtattgt gacctttttt aaaaaaaagg
2640aactgaggtt cagaatgatt aagggcctgg cccccagggt tgtccagctc
cataaggtgg 2700agctgggcaa gattttgggt ttgctgctcc ctgaagctgg
attctttcat acgatactct 2760ttctcaagaa gggggctccc tgggatctcc
aggtgtactg cacttaccct caatccagcc
2820ccggagaagc aagtgaaaag ggtgggtccc tcataggcta gaatgtgcag
ctctttctcc 2880aggtgggatg tagcacccca aagtagagct ttctgctctg
ctcctggaaa aggctaggga 2940gctggggctg gggctcccct cccatgacca
ggcagtggtc accccatggg acaggcacag 3000ctacttacgc gaacacagca
ggttggtgtg gctggctaac taggacctct cgaaagtctc 3060tgtgggggca
tgagggagaa aaggccattg ggagaattac tgcctttact ttgggactac
3120ttttatgctg ataacttggg atttcttgat agtccttcac ccctgaaacc
ccgtatttac 3180ttaacaagat ttagctctta gttcttcaag taaaattaaa
gtctcttgtg taagagccaa 3240cacatgccca gctgcggatg ggagctgttc
ctggacagcc ttctactgcc tgggaagtga 3300tggaacagga actcagggtg
cccttacccc ctccccagac ctgttccctt tctttgactg 3360acagagcacc
atccaggcaa aattagagcg ccaaatggtt ttcttctcaa tcttaaagca
3420gtataccttt ccacaggctc gtctgtgtcc ctgccactct gagttatcca
gaaaccacca 3480cctacaaatg aggggactca tctagaagac ctctaaggtc
cccttttggc tctgaggggt 3540ctctaataat ccccacttgg aattcagcac
cgcaaggaaa ttatgggtat gtgagccata 3600atatgatggc cagcaggtgg
cgctgccttc cacccatggt gatggatggt ttggaaaggg 3660aatgttggtg
ccttttgtgc cacaagttaa gatgctactg ttttaaagga aaaaaaaaaa
3720aaaaagtact gatcttcaat atgaagacat gagcttttct cgcaggaaat
tttctttttc 3780acagaactgg tgtcaggaat cactgaaggg ctaaccgtga
tagtccttgc aagtaagtca 3840aggttttatc ctgattggaa atagaagaca
tttccggttg agagaacaga ttcgttggaa 3900gcttaacttt tgttgcctct
taacgccacc aaattttagg gtaatttgat tatgaaagag 3960tgaatttttc
tggacagaaa agggagagct accaaattgt ttttttcttt ttaaaaggaa
4020gtttaatgtc cgttgtatca caaatcagtg ttaaaacacc agaactttag
ccaaaataaa 4080tgtcttacat tacaaaggta aaaaaaaaaa aaaaaa
4116133540DNAHomo sapiens 13ccagtttgct tcttggagaa cactggacag
ctgaataaat gcagtatcta aatataaaag 60aggactgcaa tgccatggct ttctgtgcta
aaatgaggag ctccaagaag actgaggtga 120acctggaggc ccctgagcca
ggggtggaag tgatcttcta tctgtcggac agggagcccc 180tccggctggg
cagtggagag tacacagcag aggaactgtg catcagggct gcacaggcat
240gccgtatctc tcctctttgt cacaacctct ttgccctgta tgacgagaac
accaagctct 300ggtatgctcc aaatcgcacc atcaccgttg atgacaagat
gtccctccgg ctccactacc 360ggatgaggtt ctatttcacc aattggcatg
gaaccaacga caatgagcag tcagtgtggc 420gtcattctcc aaagaagcag
aaaaatggct acgagaaaaa aaagattcca gatgcaaccc 480ctctccttga
tgccagctca ctggagtatc tgtttgctca gggacagtat gatttggtga
540aatgcctggc tcctattcga gaccccaaga ccgagcagga tggacatgat
attgagaacg 600agtgtctagg gatggctgtc ctggccatct cacactatgc
catgatgaag aagatgcagt 660tgccagaact gcccaaggac atcagctaca
agcgatatat tccagaaaca ttgaataagt 720ccatcagaca gaggaacctt
ctcaccagga tgcggataaa taatgttttc aaggatttcc 780taaaggaatt
taacaacaag accatttgtg acagcagcgt gtccacgcat gacctgaagg
840tgaaatactt ggctaccttg gaaactttga caaaacatta cggtgctgaa
atatttgaga 900cttccatgtt actgatttca tcagaaaatg agatgaattg
gtttcattcg aatgacggtg 960gaaacgttct ctactacgaa gtgatggtga
ctgggaatct tggaatccag tggaggcata 1020aaccaaatgt tgtttctgtt
gaaaaggaaa aaaataaact gaagcggaaa aaactggaaa 1080ataaagacaa
gaaggatgag gagaaaaaca agatccggga agagtggaac aatttttcat
1140tcttccctga aatcactcac attgtaataa aggagtctgt ggtcagcatt
aacaagcagg 1200acaacaagaa aatggaactg aagctctctt cccacgagga
ggccttgtcc tttgtgtccc 1260tggtagatgg ctacttccgg ctcacagcag
atgcccatca ttacctctgc accgacgtgg 1320cccccccgtt gatcgtccac
aacatacaga atggctgtca tggtccaatc tgtacagaat 1380acgccatcaa
taaattgcgg caagaaggaa gcgaggaggg gatgtacgtg ctgaggtgga
1440gctgcaccga ctttgacaac atcctcatga ccgtcacctg ctttgagaag
tctgagcagg 1500tgcagggtgc ccagaagcag ttcaagaact ttcagatcga
ggtgcagaag ggccgctaca 1560gtctgcacgg ttcggaccgc agcttcccca
gcttgggaga cctcatgagc cacctcaaga 1620agcagatcct gcgcacggat
aacatcagct tcatgctaaa acgctgctgc cagcccaagc 1680cccgagaaat
ctccaacctg ctggtggcta ctaagaaagc ccaggagtgg cagcccgtct
1740accccatgag ccagctgagt ttcgatcgga tcctcaagaa ggatctggtg
cagggcgagc 1800accttgggag aggcacgaga acacacatct attctgggac
cctgatggat tacaaggatg 1860acgaaggaac ttctgaagag aagaagataa
aagtgatcct caaagtctta gaccccagcc 1920acagggatat ttccctggcc
ttcttcgagg cagccagcat gatgagacag gtctcccaca 1980aacacatcgt
gtacctctat ggcgtctgtg tccgcgacgt ggagaatatc atggtggaag
2040agtttgtgga agggggtcct ctggatctct tcatgcaccg gaaaagtgat
gtccttacca 2100caccatggaa attcaaagtt gccaaacagc tggccagtgc
cctgagctac ttggaggata 2160aagacctggt ccatggaaat gtgtgtacta
aaaacctcct cctggcccgt gagggaatcg 2220acagtgagtg tggcccattc
atcaagctca gtgaccccgg catccccatt acggtgctgt 2280ctaggcaaga
atgcattgaa cgaatcccat ggattgctcc tgagtgtgtt gaggactcca
2340agaacctgag tgtggctgct gacaagtgga gctttggaac cacgctctgg
gaaatctgct 2400acaatggcga gatccccttg aaagacaaga cgctgattga
gaaagagaga ttctatgaaa 2460gccggtgcag gccagtgaca ccatcatgta
aggagctggc tgacctcatg acccgctgca 2520tgaactatga ccccaatcag
aggcctttct tccgagccat catgagagac attaataagc 2580ttgaagagca
gaatccagat attgtttcca gaaaaaaaaa ccagccaact gaagtggacc
2640ccacacattt tgagaagcgc ttcctaaaga ggatccgtga cttgggagag
ggccactttg 2700ggaaggttga gctctgcagg tatgaccccg aagacaatac
aggggagcag gtggctgtta 2760aatctctgaa gcctgagagt ggaggtaacc
acatagctga tctgaaaaag gaaatcgaga 2820tcttaaggaa cctctatcat
gagaacattg tgaagtacaa aggaatctgc acagaagacg 2880gaggaaatgg
tattaagctc atcatggaat ttctgccttc gggaagcctt aaggaatatc
2940ttccaaagaa taagaacaaa ataaacctca aacagcagct aaaatatgcc
gttcagattt 3000gtaaggggat ggactatttg ggttctcggc aatacgttca
ccgggacttg gcagcaagaa 3060atgtccttgt tgagagtgaa caccaagtga
aaattggaga cttcggttta accaaagcaa 3120ttgaaaccga taaggagtat
tacaccgtca aggatgaccg ggacagccct gtgttttggt 3180atgctccaga
atgtttaatg caatctaaat tttatattgc ctctgacgtc tggtcttttg
3240gagtcactct gcatgagctg ctgacttact gtgattcaga ttctagtccc
atggctttgt 3300tcctgaaaat gataggccca acccatggcc agatgacagt
cacaagactt gtgaatacgt 3360taaaagaagg aaaacgcctg ccgtgcccac
ctaactgtcc agatgaggtt tatcagctta 3420tgagaaaatg ctgggaattc
caaccatcca atcggacaag ctttcagaac cttattgaag 3480gatttgaagc
acttttaaaa taagaagcat gaataacatt taaattccac agattatcaa
3540143541DNAHomo sapiens 14tccagtttgc ttcttggaga acactggaca
gctgaataaa tgcagtatct aaatataaaa 60gaggactgca atgccatggc tttctgtgct
aaaatgagga gctccaagaa gactgaggtg 120aacctggagg cccctgagcc
aggggtggaa gtgatcttct atctgtcgga cagggagccc 180ctccggctgg
gcagtggaga gtacacagca gaggaactgt gcatcagggc tgcacaggca
240tgccgtatct ctcctctttg tcacaacctc tttgccctgt atgacgagaa
caccaagctc 300tggtatgctc caaatcgcac catcaccgtt gatgacaaga
tgtccctccg gctccactac 360cggatgaggt tctatttcac caattggcat
ggaaccaacg acaatgagca gtcagtgtgg 420cgtcattctc caaagaagca
gaaaaatggc tacgagaaaa aaaagattcc agatgcaacc 480cctctccttg
atgccagctc actggagtat ctgtttgctc agggacagta tgatttggtg
540aaatgcctgg ctcctattcg agaccccaag accgagcagg atggacatga
tattgagaac 600gagtgtctag ggatggctgt cctggccatc tcacactatg
ccatgatgaa gaagatgcag 660ttgccagaac tgcccaagga catcagctac
aagcgatata ttccagaaac attgaataag 720tccatcagac agaggaacct
tctcaccagg atgcggataa ataatgtttt caaggatttc 780ctaaaggaat
ttaacaacaa gaccatttgt gacagcagcg tgtccacgca tgacctgaag
840gtgaaatact tggctacctt ggaaactttg acaaaacatt acggtgctga
aatatttgag 900acttccatgt tactgatttc atcagaaaat gagatgaatt
ggtttcattc gaatgacggt 960ggaaacgttc tctactacga agtgatggtg
actgggaatc ttggaatcca gtggaggcat 1020aaaccaaatg ttgtttctgt
tgaaaaggaa aaaaataaac tgaagcggaa aaaactggaa 1080aataaagaca
agaaggatga ggagaaaaac aagatccggg aagagtggaa caatttttca
1140ttcttccctg aaatcactca cattgtaata aaggagtctg tggtcagcat
taacaagcag 1200gacaacaaga aaatggaact gaagctctct tcccacgagg
aggccttgtc ctttgtgtcc 1260ctggtagatg gctacttccg gctcacagca
gatgcccatc attacctctg caccgacgtg 1320gcccccccgt tgatcgtcca
caacatacag aatggctgtc atggtccaat ctgtacagaa 1380tacgccatca
ataaattgcg gcaagaagga agcgaggagg ggatgtacgt gctgaggtgg
1440agctgcaccg actttgacaa catcctcatg accgtcacct gctttgagaa
gtctgagcag 1500gtgcagggtg cccagaagca gttcaagaac tttcagatcg
aggtgcagaa gggccgctac 1560agtctgcacg gttcggaccg cagcttcccc
agcttgggag acctcatgag ccacctcaag 1620aagcagatcc tgcgcacgga
taacatcagc ttcatgctaa aacgctgctg ccagcccaag 1680ccccgagaaa
tctccaacct gctggtggct actaagaaag cccaggagtg gcagcccgtc
1740taccccatga gccagctgag tttcgatcgg atcctcaaga aggatctggt
gcagggcgag 1800caccttggga gaggcacgag aacacacatc tattctggga
ccctgatgga ttacaaggat 1860gacgaaggaa cttctgaaga gaagaagata
aaagtgatcc tcaaagtctt agaccccagc 1920cacagggata tttccctggc
cttcttcgag gcagccagca tgatgagaca ggtctcccac 1980aaacacatcg
tgtacctcta tggcgtctgt gtccgcgacg tggagaatat catggtggaa
2040gagtttgtgg aagggggtcc tctggatctc ttcatgcacc ggaaaagtga
tgtccttacc 2100acaccatgga aattcaaagt tgccaaacag ctggccagtg
ccctgagcta cttggaggat 2160aaagacctgg tccatggaaa tgtgtgtact
aaaaacctcc tcctggcccg tgagggaatc 2220gacagtgagt gtggcccatt
catcaagctc agtgaccccg gcatccccat tacggtgctg 2280tctaggcaag
aatgcattga acgaatccca tggattgctc ctgagtgtgt tgaggactcc
2340aagaacctga gtgtggctgc tgacaagtgg agctttggaa ccacgctctg
ggaaatctgc 2400tacaatggcg agatcccctt gaaagacaag acgctgattg
agaaagagag attctatgaa 2460agccggtgca ggccagtgac accatcatgt
aaggagctgg ctgacctcat gacccgctgc 2520atgaactatg accccaatca
gaggcctttc ttccgagcca tcatgagaga cattaataag 2580cttgaagagc
agaatccaga tattgtttcc agaaaaaaaa accagccaac tgaagtggac
2640cccacacatt ttgagaagcg cttcctaaag aggatccgtg acttgggaga
gggccacttt 2700gggaaggttg agctctgcag gtatgacccc gaagacaata
caggggagca ggtggctgtt 2760aaatctctga agcctgagag tggaggtaac
cacatagctg atctgaaaaa ggaaatcgag 2820atcttaagga acctctatca
tgagaacatt gtgaagtaca aaggaatctg cacagaagac 2880ggaggaaatg
gtattaagct catcatggaa tttctgcctt cgggaagcct taaggaatat
2940cttccaaaga ataagaacaa aataaacctc aaacagcagc taaaatatgc
cgttcagatt 3000tgtaagggga tggactattt gggttctcgg caatacgttc
accgggactt ggcagcaaga 3060aatgtccttg ttgagagtga acaccaagtg
aaaattggag acttcggttt aaccaaagca 3120attgaaaccg ataaggagta
ttacaccgtc aaggatgacc gggacagccc tgtgttttgg 3180tatgctccag
aatgtttaat gcaatctaaa ttttatattg cctctgacgt ctggtctttt
3240ggagtcactc tgcatgagct gctgacttac tgtgattcag attctagtcc
catggctttg 3300ttcctgaaaa tgataggccc aacccatggc cagatgacag
tcacaagact tgtgaatacg 3360ttaaaagaag gaaaacgcct gccgtgccca
cctaactgtc cagatgaggt ttatcagctt 3420atgagaaaat gctgggaatt
ccaaccatcc aatcggacaa gctttcagaa ccttattgaa 3480ggatttgaag
cacttttaaa ataagaagca tgaataacat ttaaattcca cagattatca 3540a
3541152982DNAHomo sapiens 15cgcaccccgc gcagcggctg agccgggagc
cagcgcagcc tcggccccgc agctcaagcc 60tcgtccccgc cgccgccgcc gccgccgccg
ccgccgcccc cggggcatgg cctgtctgat 120ggccgctttc tcggtcggca
ccgccatgaa tgccagcagt tactctgcag agatgacgga 180gcccaagtcg
gtgtgtgtct cggtggatga ggtggtgtcc agcaacatgg aggccactga
240gacggacctg ctgaatggac atctgaaaaa agtagataat aacctcacgg
aagcccagcg 300cttctcctcc ttgcctcgga gggcagctgt gaacattgaa
ttcagggacc tttcctattc 360ggttcctgaa ggaccctggt ggaggaagaa
aggatacaag accctcctga aaggaatttc 420cgggaagttc aatagtggtg
agttggtggc cattatgggt ccttccgggg ccgggaagtc 480cacgctgatg
aacatcctgg ctggatacag ggagacgggc atgaaggggg ccgtcctcat
540caacggcctg ccccgggacc tgcgctgctt ccggaaggtg tcctgctaca
tcatgcagga 600tgacatgctg ctgccgcatc tcactgtgca ggaggccatg
atggtgtcgg cacatctgaa 660gcttcaggag aaggatgaag gcagaaggga
aatggtcaag gagatactga cagcgctggg 720cttgctgtct tgcgccaaca
cgcggaccgg gagcctgtca ggtggtcagc gcaagcgcct 780ggccatcgcg
ctggagctgg tgaacaaccc tccagtcatg ttcttcgatg agcccaccag
840cggcctggac agcgcctcct gcttccaggt ggtctcgctg atgaaagggc
tcgctcaagg 900gggtcgctcc atcatttgca ccatccacca gcccagcgcc
aaactcttcg agctgttcga 960ccagctttac gtcctgagtc aaggacaatg
tgtgtaccgg ggaaaagtct gcaatcttgt 1020gccatatttg agggatttgg
gtctgaactg cccaacctac cacaacccag cagattttgt 1080catggaggtt
gcatccggcg agtacggtga tcagaacagt cggctggtga gagcggttcg
1140ggagggcatg tgtgactcag accacaagag agacctcggg ggtgatgccg
aggtgaaccc 1200ttttctttgg caccggccct ctgaagagga ctcctcgtcc
atggaaggct gccacagctt 1260ctctgccagc tgcctcacgc agttctgcat
cctcttcaag aggaccttcc tcagcatcat 1320gagggactcg gtcctgacac
acctgcgcat cacctcgcac attgggatcg gcctcctcat 1380tggcctgctg
tacttgggga tcgggaacga agccaagaag gtcttgagca actccggctt
1440cctcttcttc tccatgctgt tcctcatgtt cgcggccctc atgcctactg
ttctgacatt 1500tcccctggag atgggagtct ttcttcggga acacctgaac
tactggtaca gcctgaaggc 1560ctactacctg gccaagacca tggcagacgt
gccctttcag atcatgttcc cagtggccta 1620ctgcagcatc gtgtactgga
tgacgtcgca gccgtccgac gccgtgcgct ttgtgctgtt 1680tgccgcgctg
ggcaccatga cctccctggt ggcacagtcc ctgggcctgc tgatcggagc
1740cgcctccacg tccctgcagg tggccacttt cgtgggccca gtgacagcca
tcccggtgct 1800cctgttctcg gggttcttcg tcagcttcga caccatcccc
acgtacctac agtggatgtc 1860ctacatctcc tatgtcaggt atgggttcga
aggggtcatc ctctccatct atggcttaga 1920ccgggaagat ctgcactgtg
acatcgacga gacgtgccac ttccagaagt cggaggccat 1980cctgcgggag
ctggacgtgg aaaatgccaa gctgtacctg gacttcatcg tactcgggat
2040tttcttcatc tccctccgcc tcattgccta ttttgtcctc aggtacaaaa
tccgggcaga 2100gaggtaaaac acctgaatgc caggaaacag gaagattaga
cactgtggcc gagggcacgt 2160ctagaatcga ggaggcaagc ctgtgcccga
ccgacgacac agagactctt ctgatccaac 2220ccctagaacc gcgttgggtt
tgtgggtgtc tcgtgctcag ccactctgcc cagctgggtt 2280ggatcttctc
tccattcccc tttctagctt taactaggaa gatgtaggca gattggtggt
2340tttttttttt ttaacataca gaattttaaa taccacaact ggggcagaat
ttaaagctgc 2400aacacagctg gtgatgagag gcttcctcag tccagtcgct
ccttagcacc aggcaccgtg 2460ggtcctggat ggggaactgc aagcagcctc
tcagctgatg gctgcacagt cagatgtctg 2520gtggcagaga gtccgagcat
ggagcgattc cattttatga ctgttgtttt tcacattttc 2580atctttctaa
ggtgtgtctc ttttccaatg agaagtcatt tttgcaagcc aaaagtcgat
2640caatcgcatt cattttaaga aattatacct ttttagtact tgctgaagaa
tgattcaggg 2700taaatcacat actttgttta gagaggcgag gggtttaacc
gagtcaccca gctggtctca 2760tacatagaca gcacttgtga aggattgaat
gcaggttcca ggtggaggga agacgtggac 2820accatctcca ctgagccatg
cagacatttt taaaagctat acaaaaaatt gtgagaagac 2880attggccaac
tctttcaaag tctttctttt tccacgtgct tcttatttta agcgaaatat
2940attgtttgtt tcttcctaaa aaaaaaaaaa aaaaaaaaaa aa
2982163018DNAHomo sapiens 16cgcaccccgc gcagcggctg agccgggagc
cagcgcagcc tcggccccgc agctcaagcc 60tcgtccccgc cgccgccgcc gccgccgccg
ccgccgcccc cggggcatgg cctgtctgat 120ggccgctttc tcggtcggca
ccgccatgaa tgccagcagt tactctgcag agatgacgga 180gcccaagtcg
gtgtgtgtct cggtggatga ggtggtgtcc agcaacatgg aggccactga
240gacggacctg ctgaatggac atctgaaaaa agtagataat aacctcacgg
aagcccagcg 300cttctcctcc ttgcctcgga gggcagctgt gaacattgaa
ttcagggacc tttcctattc 360ggttcctgaa ggaccctggt ggaggaagaa
aggatacaag accctcctga aaggaatttc 420cgggaagttc aatagtggtg
agttggtggc cattatgggt ccttccgggg ccgggaagtc 480cacgctgatg
aacatcctgg ctggatacag ggagacgggc atgaaggggg ccgtcctcat
540caacggcctg ccccgggacc tgcgctgctt ccggaaggtg tcctgctaca
tcatgcagga 600tgacatgctg ctgccgcatc tcactgtgca ggaggccatg
atggtgtcgg cacatctgaa 660gcttcaggag aaggatgaag gcagaaggga
aatggtcaag gagatactga cagcgctggg 720cttgctgtct tgcgccaaca
cgcggaccgg gagcctgtca ggtggtcagc gcaagcgcct 780ggccatcgcg
ctggagctgg tgaacaaccc tccagtcatg ttcttcgatg agcccaccag
840cggcctggac agcgcctcct gcttccaggt ggtctcgctg atgaaagggc
tcgctcaagg 900gggtcgctcc atcatttgca ccatccacca gcccagcgcc
aaactcttcg agctgttcga 960ccagctttac gtcctgagtc aaggacaatg
tgtgtaccgg ggaaaagtct gcaatcttgt 1020gccatatttg agggatttgg
gtctgaactg cccaacctac cacaacccag cagattttgt 1080catggaggtt
gcatccggcg agtacggtga tcagaacagt cggctggtga gagcggttcg
1140ggagggcatg tgtgactcag accacaagag agacctcggg ggtgatgccg
aggtgaaccc 1200ttttctttgg caccggccct ctgaagaggt aaagcagaca
aaacgattaa aggggttgag 1260aaaggactcc tcgtccatgg aaggctgcca
cagcttctct gccagctgcc tcacgcagtt 1320ctgcatcctc ttcaagagga
ccttcctcag catcatgagg gactcggtcc tgacacacct 1380gcgcatcacc
tcgcacattg ggatcggcct cctcattggc ctgctgtact tggggatcgg
1440gaacgaagcc aagaaggtct tgagcaactc cggcttcctc ttcttctcca
tgctgttcct 1500catgttcgcg gccctcatgc ctactgttct gacatttccc
ctggagatgg gagtctttct 1560tcgggaacac ctgaactact ggtacagcct
gaaggcctac tacctggcca agaccatggc 1620agacgtgccc tttcagatca
tgttcccagt ggcctactgc agcatcgtgt actggatgac 1680gtcgcagccg
tccgacgccg tgcgctttgt gctgtttgcc gcgctgggca ccatgacctc
1740cctggtggca cagtccctgg gcctgctgat cggagccgcc tccacgtccc
tgcaggtggc 1800cactttcgtg ggcccagtga cagccatccc ggtgctcctg
ttctcggggt tcttcgtcag 1860cttcgacacc atccccacgt acctacagtg
gatgtcctac atctcctatg tcaggtatgg 1920gttcgaaggg gtcatcctct
ccatctatgg cttagaccgg gaagatctgc actgtgacat 1980cgacgagacg
tgccacttcc agaagtcgga ggccatcctg cgggagctgg acgtggaaaa
2040tgccaagctg tacctggact tcatcgtact cgggattttc ttcatctccc
tccgcctcat 2100tgcctatttt gtcctcaggt acaaaatccg ggcagagagg
taaaacacct gaatgccagg 2160aaacaggaag attagacact gtggccgagg
gcacgtctag aatcgaggag gcaagcctgt 2220gcccgaccga cgacacagag
actcttctga tccaacccct agaaccgcgt tgggtttgtg 2280ggtgtctcgt
gctcagccac tctgcccagc tgggttggat cttctctcca ttcccctttc
2340tagctttaac taggaagatg taggcagatt ggtggttttt ttttttttaa
catacagaat 2400tttaaatacc acaactgggg cagaatttaa agctgcaaca
cagctggtga tgagaggctt 2460cctcagtcca gtcgctcctt agcaccaggc
accgtgggtc ctggatgggg aactgcaagc 2520agcctctcag ctgatggctg
cacagtcaga tgtctggtgg cagagagtcc gagcatggag 2580cgattccatt
ttatgactgt tgtttttcac attttcatct ttctaaggtg tgtctctttt
2640ccaatgagaa gtcatttttg caagccaaaa gtcgatcaat cgcattcatt
ttaagaaatt 2700ataccttttt agtacttgct gaagaatgat tcagggtaaa
tcacatactt tgtttagaga 2760ggcgaggggt ttaaccgagt cacccagctg
gtctcataca tagacagcac ttgtgaagga 2820ttgaatgcag gttccaggtg
gagggaagac gtggacacca tctccactga gccatgcaga 2880catttttaaa
agctatacaa aaaattgtga gaagacattg gccaactctt tcaaagtctt
2940tctttttcca cgtgcttctt attttaagcg aaatatattg tttgtttctt
cctaaaaaaa 3000aaaaaaaaaa aaaaaaaa 3018172983DNAHomo sapiens
17gcgaggggca agcccggatt cctgccggcc gcctttctgc gcgcgccgga gagagagacg
60cggtggggac agggatgcgc atttcacttc cccgagctcc ggagagggat ggcggggtgt
120cggcgagttc actgctggac acagttacta atgccagcag ttactctgca
gagatgacgg 180agcccaagtc ggtgtgtgtc tcggtggatg aggtggtgtc
cagcaacatg gaggccactg 240agacggacct gctgaatgga catctgaaaa
aagtagataa taacctcacg gaagcccagc 300gcttctcctc cttgcctcgg
agggcagctg tgaacattga attcagggac ctttcctatt 360cggttcctga
aggaccctgg tggaggaaga aaggatacaa gaccctcctg aaaggaattt
420ccgggaagtt caatagtggt
gagttggtgg ccattatggg tccttccggg gccgggaagt 480ccacgctgat
gaacatcctg gctggataca gggagacggg catgaagggg gccgtcctca
540tcaacggcct gccccgggac ctgcgctgct tccggaaggt gtcctgctac
atcatgcagg 600atgacatgct gctgccgcat ctcactgtgc aggaggccat
gatggtgtcg gcacatctga 660agcttcagga gaaggatgaa ggcagaaggg
aaatggtcaa ggagatactg acagcgctgg 720gcttgctgtc ttgcgccaac
acgcggaccg ggagcctgtc aggtggtcag cgcaagcgcc 780tggccatcgc
gctggagctg gtgaacaacc ctccagtcat gttcttcgat gagcccacca
840gcggcctgga cagcgcctcc tgcttccagg tggtctcgct gatgaaaggg
ctcgctcaag 900ggggtcgctc catcatttgc accatccacc agcccagcgc
caaactcttc gagctgttcg 960accagcttta cgtcctgagt caaggacaat
gtgtgtaccg gggaaaagtc tgcaatcttg 1020tgccatattt gagggatttg
ggtctgaact gcccaaccta ccacaaccca gcagattttg 1080tcatggaggt
tgcatccggc gagtacggtg atcagaacag tcggctggtg agagcggttc
1140gggagggcat gtgtgactca gaccacaaga gagacctcgg gggtgatgcc
gaggtgaacc 1200cttttctttg gcaccggccc tctgaagagg actcctcgtc
catggaaggc tgccacagct 1260tctctgccag ctgcctcacg cagttctgca
tcctcttcaa gaggaccttc ctcagcatca 1320tgagggactc ggtcctgaca
cacctgcgca tcacctcgca cattgggatc ggcctcctca 1380ttggcctgct
gtacttgggg atcgggaacg aagccaagaa ggtcttgagc aactccggct
1440tcctcttctt ctccatgctg ttcctcatgt tcgcggccct catgcctact
gttctgacat 1500ttcccctgga gatgggagtc tttcttcggg aacacctgaa
ctactggtac agcctgaagg 1560cctactacct ggccaagacc atggcagacg
tgccctttca gatcatgttc ccagtggcct 1620actgcagcat cgtgtactgg
atgacgtcgc agccgtccga cgccgtgcgc tttgtgctgt 1680ttgccgcgct
gggcaccatg acctccctgg tggcacagtc cctgggcctg ctgatcggag
1740ccgcctccac gtccctgcag gtggccactt tcgtgggccc agtgacagcc
atcccggtgc 1800tcctgttctc ggggttcttc gtcagcttcg acaccatccc
cacgtaccta cagtggatgt 1860cctacatctc ctatgtcagg tatgggttcg
aaggggtcat cctctccatc tatggcttag 1920accgggaaga tctgcactgt
gacatcgacg agacgtgcca cttccagaag tcggaggcca 1980tcctgcggga
gctggacgtg gaaaatgcca agctgtacct ggacttcatc gtactcggga
2040ttttcttcat ctccctccgc ctcattgcct attttgtcct caggtacaaa
atccgggcag 2100agaggtaaaa cacctgaatg ccaggaaaca ggaagattag
acactgtggc cgagggcacg 2160tctagaatcg aggaggcaag cctgtgcccg
accgacgaca cagagactct tctgatccaa 2220cccctagaac cgcgttgggt
ttgtgggtgt ctcgtgctca gccactctgc ccagctgggt 2280tggatcttct
ctccattccc ctttctagct ttaactagga agatgtaggc agattggtgg
2340tttttttttt tttaacatac agaattttaa ataccacaac tggggcagaa
tttaaagctg 2400caacacagct ggtgatgaga ggcttcctca gtccagtcgc
tccttagcac caggcaccgt 2460gggtcctgga tggggaactg caagcagcct
ctcagctgat ggctgcacag tcagatgtct 2520ggtggcagag agtccgagca
tggagcgatt ccattttatg actgttgttt ttcacatttt 2580catctttcta
aggtgtgtct cttttccaat gagaagtcat ttttgcaagc caaaagtcga
2640tcaatcgcat tcattttaag aaattatacc tttttagtac ttgctgaaga
atgattcagg 2700gtaaatcaca tactttgttt agagaggcga ggggtttaac
cgagtcaccc agctggtctc 2760atacatagac agcacttgtg aaggattgaa
tgcaggttcc aggtggaggg aagacgtgga 2820caccatctcc actgagccat
gcagacattt ttaaaagcta tacaaaaaat tgtgagaaga 2880cattggccaa
ctctttcaaa gtctttcttt ttccacgtgc ttcttatttt aagcgaaata
2940tattgtttgt ttcttcctaa aaaaaaaaaa aaaaaaaaaa aaa
2983183142DNAHomo sapiens 18agacactgaa tcatcatttg tagtttgggg
ggctttacat gcctgcagtg gtgaaaactg 60aaattttgtc ccacttaagg gagtttcttc
ttccctttat taattgcaaa ataaatatat 120gtcacttcag agggcagcag
ctggactacc tatgtttgtg gcgctacacc aacctgaact 180tcgcttcctg
agacctaaga ttcagccccg tgctcagcag acatcaggga tcaccgactc
240tgtgccagga gctgttcttg atgctgggaa cgcaggggtg gacaaaacag
agaaagccct 300gccctcagaa tgccagcagt tactctgcag agatgacgga
gcccaagtcg gtgtgtgtct 360cggtggatga ggtggtgtcc agcaacatgg
aggccactga gacggacctg ctgaatggac 420atctgaaaaa agtagataat
aacctcacgg aagcccagcg cttctcctcc ttgcctcgga 480gggcagctgt
gaacattgaa ttcagggacc tttcctattc ggttcctgaa ggaccctggt
540ggaggaagaa aggatacaag accctcctga aaggaatttc cgggaagttc
aatagtggtg 600agttggtggc cattatgggt ccttccgggg ccgggaagtc
cacgctgatg aacatcctgg 660ctggatacag ggagacgggc atgaaggggg
ccgtcctcat caacggcctg ccccgggacc 720tgcgctgctt ccggaaggtg
tcctgctaca tcatgcagga tgacatgctg ctgccgcatc 780tcactgtgca
ggaggccatg atggtgtcgg cacatctgaa gcttcaggag aaggatgaag
840gcagaaggga aatggtcaag gagatactga cagcgctggg cttgctgtct
tgcgccaaca 900cgcggaccgg gagcctgtca ggtggtcagc gcaagcgcct
ggccatcgcg ctggagctgg 960tgaacaaccc tccagtcatg ttcttcgatg
agcccaccag cggcctggac agcgcctcct 1020gcttccaggt ggtctcgctg
atgaaagggc tcgctcaagg gggtcgctcc atcatttgca 1080ccatccacca
gcccagcgcc aaactcttcg agctgttcga ccagctttac gtcctgagtc
1140aaggacaatg tgtgtaccgg ggaaaagtct gcaatcttgt gccatatttg
agggatttgg 1200gtctgaactg cccaacctac cacaacccag cagattttgt
catggaggtt gcatccggcg 1260agtacggtga tcagaacagt cggctggtga
gagcggttcg ggagggcatg tgtgactcag 1320accacaagag agacctcggg
ggtgatgccg aggtgaaccc ttttctttgg caccggccct 1380ctgaagagga
ctcctcgtcc atggaaggct gccacagctt ctctgccagc tgcctcacgc
1440agttctgcat cctcttcaag aggaccttcc tcagcatcat gagggactcg
gtcctgacac 1500acctgcgcat cacctcgcac attgggatcg gcctcctcat
tggcctgctg tacttgggga 1560tcgggaacga agccaagaag gtcttgagca
actccggctt cctcttcttc tccatgctgt 1620tcctcatgtt cgcggccctc
atgcctactg ttctgacatt tcccctggag atgggagtct 1680ttcttcggga
acacctgaac tactggtaca gcctgaaggc ctactacctg gccaagacca
1740tggcagacgt gccctttcag atcatgttcc cagtggccta ctgcagcatc
gtgtactgga 1800tgacgtcgca gccgtccgac gccgtgcgct ttgtgctgtt
tgccgcgctg ggcaccatga 1860cctccctggt ggcacagtcc ctgggcctgc
tgatcggagc cgcctccacg tccctgcagg 1920tggccacttt cgtgggccca
gtgacagcca tcccggtgct cctgttctcg gggttcttcg 1980tcagcttcga
caccatcccc acgtacctac agtggatgtc ctacatctcc tatgtcaggt
2040atgggttcga aggggtcatc ctctccatct atggcttaga ccgggaagat
ctgcactgtg 2100acatcgacga gacgtgccac ttccagaagt cggaggccat
cctgcgggag ctggacgtgg 2160aaaatgccaa gctgtacctg gacttcatcg
tactcgggat tttcttcatc tccctccgcc 2220tcattgccta ttttgtcctc
aggtacaaaa tccgggcaga gaggtaaaac acctgaatgc 2280caggaaacag
gaagattaga cactgtggcc gagggcacgt ctagaatcga ggaggcaagc
2340ctgtgcccga ccgacgacac agagactctt ctgatccaac ccctagaacc
gcgttgggtt 2400tgtgggtgtc tcgtgctcag ccactctgcc cagctgggtt
ggatcttctc tccattcccc 2460tttctagctt taactaggaa gatgtaggca
gattggtggt tttttttttt ttaacataca 2520gaattttaaa taccacaact
ggggcagaat ttaaagctgc aacacagctg gtgatgagag 2580gcttcctcag
tccagtcgct ccttagcacc aggcaccgtg ggtcctggat ggggaactgc
2640aagcagcctc tcagctgatg gctgcacagt cagatgtctg gtggcagaga
gtccgagcat 2700ggagcgattc cattttatga ctgttgtttt tcacattttc
atctttctaa ggtgtgtctc 2760ttttccaatg agaagtcatt tttgcaagcc
aaaagtcgat caatcgcatt cattttaaga 2820aattatacct ttttagtact
tgctgaagaa tgattcaggg taaatcacat actttgttta 2880gagaggcgag
gggtttaacc gagtcaccca gctggtctca tacatagaca gcacttgtga
2940aggattgaat gcaggttcca ggtggaggga agacgtggac accatctcca
ctgagccatg 3000cagacatttt taaaagctat acaaaaaatt gtgagaagac
attggccaac tctttcaaag 3060tctttctttt tccacgtgct tcttatttta
agcgaaatat attgtttgtt tcttcctaaa 3120aaaaaaaaaa aaaaaaaaaa aa
3142193060DNAHomo sapiens 19acttcagagg gcagcagctg gactacctat
gtttgtggcg ctacaccaac ctgaacttcg 60cttcctgaga cctaagattc agccccgtgc
tcagcagaca tcagggatca ccgactctgt 120gccaggagct gttcttgatg
ctgggaacgc aggggtggac aaaacagaga aagccctgcc 180ctcagtgaga
aatatgctgt catgtaaatt gctttttccc ctatagaatg ccagcagtta
240ctctgcagag atgacggagc ccaagtcggt gtgtgtctcg gtggatgagg
tggtgtccag 300caacatggag gccactgaga cggacctgct gaatggacat
ctgaaaaaag tagataataa 360cctcacggaa gcccagcgct tctcctcctt
gcctcggagg gcagctgtga acattgaatt 420cagggacctt tcctattcgg
ttcctgaagg accctggtgg aggaagaaag gatacaagac 480cctcctgaaa
ggaatttccg ggaagttcaa tagtggtgag ttggtggcca ttatgggtcc
540ttccggggcc gggaagtcca cgctgatgaa catcctggct ggatacaggg
agacgggcat 600gaagggggcc gtcctcatca acggcctgcc ccgggacctg
cgctgcttcc ggaaggtgtc 660ctgctacatc atgcaggatg acatgctgct
gccgcatctc actgtgcagg aggccatgat 720ggtgtcggca catctgaagc
ttcaggagaa ggatgaaggc agaagggaaa tggtcaagga 780gatactgaca
gcgctgggct tgctgtcttg cgccaacacg cggaccggga gcctgtcagg
840tggtcagcgc aagcgcctgg ccatcgcgct ggagctggtg aacaaccctc
cagtcatgtt 900cttcgatgag cccaccagcg gcctggacag cgcctcctgc
ttccaggtgg tctcgctgat 960gaaagggctc gctcaagggg gtcgctccat
catttgcacc atccaccagc ccagcgccaa 1020actcttcgag ctgttcgacc
agctttacgt cctgagtcaa ggacaatgtg tgtaccgggg 1080aaaagtctgc
aatcttgtgc catatttgag ggatttgggt ctgaactgcc caacctacca
1140caacccagca gattttgtca tggaggttgc atccggcgag tacggtgatc
agaacagtcg 1200gctggtgaga gcggttcggg agggcatgtg tgactcagac
cacaagagag acctcggggg 1260tgatgccgag gtgaaccctt ttctttggca
ccggccctct gaagaggact cctcgtccat 1320ggaaggctgc cacagcttct
ctgccagctg cctcacgcag ttctgcatcc tcttcaagag 1380gaccttcctc
agcatcatga gggactcggt cctgacacac ctgcgcatca cctcgcacat
1440tgggatcggc ctcctcattg gcctgctgta cttggggatc gggaacgaag
ccaagaaggt 1500cttgagcaac tccggcttcc tcttcttctc catgctgttc
ctcatgttcg cggccctcat 1560gcctactgtt ctgacatttc ccctggagat
gggagtcttt cttcgggaac acctgaacta 1620ctggtacagc ctgaaggcct
actacctggc caagaccatg gcagacgtgc cctttcagat 1680catgttccca
gtggcctact gcagcatcgt gtactggatg acgtcgcagc cgtccgacgc
1740cgtgcgcttt gtgctgtttg ccgcgctggg caccatgacc tccctggtgg
cacagtccct 1800gggcctgctg atcggagccg cctccacgtc cctgcaggtg
gccactttcg tgggcccagt 1860gacagccatc ccggtgctcc tgttctcggg
gttcttcgtc agcttcgaca ccatccccac 1920gtacctacag tggatgtcct
acatctccta tgtcaggtat gggttcgaag gggtcatcct 1980ctccatctat
ggcttagacc gggaagatct gcactgtgac atcgacgaga cgtgccactt
2040ccagaagtcg gaggccatcc tgcgggagct ggacgtggaa aatgccaagc
tgtacctgga 2100cttcatcgta ctcgggattt tcttcatctc cctccgcctc
attgcctatt ttgtcctcag 2160gtacaaaatc cgggcagaga ggtaaaacac
ctgaatgcca ggaaacagga agattagaca 2220ctgtggccga gggcacgtct
agaatcgagg aggcaagcct gtgcccgacc gacgacacag 2280agactcttct
gatccaaccc ctagaaccgc gttgggtttg tgggtgtctc gtgctcagcc
2340actctgccca gctgggttgg atcttctctc cattcccctt tctagcttta
actaggaaga 2400tgtaggcaga ttggtggttt tttttttttt aacatacaga
attttaaata ccacaactgg 2460ggcagaattt aaagctgcaa cacagctggt
gatgagaggc ttcctcagtc cagtcgctcc 2520ttagcaccag gcaccgtggg
tcctggatgg ggaactgcaa gcagcctctc agctgatggc 2580tgcacagtca
gatgtctggt ggcagagagt ccgagcatgg agcgattcca ttttatgact
2640gttgtttttc acattttcat ctttctaagg tgtgtctctt ttccaatgag
aagtcatttt 2700tgcaagccaa aagtcgatca atcgcattca ttttaagaaa
ttataccttt ttagtacttg 2760ctgaagaatg attcagggta aatcacatac
tttgtttaga gaggcgaggg gtttaaccga 2820gtcacccagc tggtctcata
catagacagc acttgtgaag gattgaatgc aggttccagg 2880tggagggaag
acgtggacac catctccact gagccatgca gacattttta aaagctatac
2940aaaaaattgt gagaagacat tggccaactc tttcaaagtc tttctttttc
cacgtgcttc 3000ttattttaag cgaaatatat tgtttgtttc ttcctaaaaa
aaaaaaaaaa aaaaaaaaaa 3060202946DNAHomo sapiens 20gctttataaa
ggggagtttc cctgcacaag ctctctctct tgtctgccgc catgtgagac 60atgcctttca
ccttccgcca tgatcatgag gcttccccag ccacatggaa ctaatgccag
120cagttactct gcagagatga cggagcccaa gtcggtgtgt gtctcggtgg
atgaggtggt 180gtccagcaac atggaggcca ctgagacgga cctgctgaat
ggacatctga aaaaagtaga 240taataacctc acggaagccc agcgcttctc
ctccttgcct cggagggcag ctgtgaacat 300tgaattcagg gacctttcct
attcggttcc tgaaggaccc tggtggagga agaaaggata 360caagaccctc
ctgaaaggaa tttccgggaa gttcaatagt ggtgagttgg tggccattat
420gggtccttcc ggggccggga agtccacgct gatgaacatc ctggctggat
acagggagac 480gggcatgaag ggggccgtcc tcatcaacgg cctgccccgg
gacctgcgct gcttccggaa 540ggtgtcctgc tacatcatgc aggatgacat
gctgctgccg catctcactg tgcaggaggc 600catgatggtg tcggcacatc
tgaagcttca ggagaaggat gaaggcagaa gggaaatggt 660caaggagata
ctgacagcgc tgggcttgct gtcttgcgcc aacacgcgga ccgggagcct
720gtcaggtggt cagcgcaagc gcctggccat cgcgctggag ctggtgaaca
accctccagt 780catgttcttc gatgagccca ccagcggcct ggacagcgcc
tcctgcttcc aggtggtctc 840gctgatgaaa gggctcgctc aagggggtcg
ctccatcatt tgcaccatcc accagcccag 900cgccaaactc ttcgagctgt
tcgaccagct ttacgtcctg agtcaaggac aatgtgtgta 960ccggggaaaa
gtctgcaatc ttgtgccata tttgagggat ttgggtctga actgcccaac
1020ctaccacaac ccagcagatt ttgtcatgga ggttgcatcc ggcgagtacg
gtgatcagaa 1080cagtcggctg gtgagagcgg ttcgggaggg catgtgtgac
tcagaccaca agagagacct 1140cgggggtgat gccgaggtga acccttttct
ttggcaccgg ccctctgaag aggactcctc 1200gtccatggaa ggctgccaca
gcttctctgc cagctgcctc acgcagttct gcatcctctt 1260caagaggacc
ttcctcagca tcatgaggga ctcggtcctg acacacctgc gcatcacctc
1320gcacattggg atcggcctcc tcattggcct gctgtacttg gggatcggga
acgaagccaa 1380gaaggtcttg agcaactccg gcttcctctt cttctccatg
ctgttcctca tgttcgcggc 1440cctcatgcct actgttctga catttcccct
ggagatggga gtctttcttc gggaacacct 1500gaactactgg tacagcctga
aggcctacta cctggccaag accatggcag acgtgccctt 1560tcagatcatg
ttcccagtgg cctactgcag catcgtgtac tggatgacgt cgcagccgtc
1620cgacgccgtg cgctttgtgc tgtttgccgc gctgggcacc atgacctccc
tggtggcaca 1680gtccctgggc ctgctgatcg gagccgcctc cacgtccctg
caggtggcca ctttcgtggg 1740cccagtgaca gccatcccgg tgctcctgtt
ctcggggttc ttcgtcagct tcgacaccat 1800ccccacgtac ctacagtgga
tgtcctacat ctcctatgtc aggtatgggt tcgaaggggt 1860catcctctcc
atctatggct tagaccggga agatctgcac tgtgacatcg acgagacgtg
1920ccacttccag aagtcggagg ccatcctgcg ggagctggac gtggaaaatg
ccaagctgta 1980cctggacttc atcgtactcg ggattttctt catctccctc
cgcctcattg cctattttgt 2040cctcaggtac aaaatccggg cagagaggta
aaacacctga atgccaggaa acaggaagat 2100tagacactgt ggccgagggc
acgtctagaa tcgaggaggc aagcctgtgc ccgaccgacg 2160acacagagac
tcttctgatc caacccctag aaccgcgttg ggtttgtggg tgtctcgtgc
2220tcagccactc tgcccagctg ggttggatct tctctccatt cccctttcta
gctttaacta 2280ggaagatgta ggcagattgg tggttttttt ttttttaaca
tacagaattt taaataccac 2340aactggggca gaatttaaag ctgcaacaca
gctggtgatg agaggcttcc tcagtccagt 2400cgctccttag caccaggcac
cgtgggtcct ggatggggaa ctgcaagcag cctctcagct 2460gatggctgca
cagtcagatg tctggtggca gagagtccga gcatggagcg attccatttt
2520atgactgttg tttttcacat tttcatcttt ctaaggtgtg tctcttttcc
aatgagaagt 2580catttttgca agccaaaagt cgatcaatcg cattcatttt
aagaaattat acctttttag 2640tacttgctga agaatgattc agggtaaatc
acatactttg tttagagagg cgaggggttt 2700aaccgagtca cccagctggt
ctcatacata gacagcactt gtgaaggatt gaatgcaggt 2760tccaggtgga
gggaagacgt ggacaccatc tccactgagc catgcagaca tttttaaaag
2820ctatacaaaa aattgtgaga agacattggc caactctttc aaagtctttc
tttttccacg 2880tgcttcttat tttaagcgaa atatattgtt tgtttcttcc
taaaaaaaaa aaaaaaaaaa 2940aaaaaa 2946213498DNAHomo sapiens
21ttctttccaa gggtctctgg gtgaggcccg tgaccttccc aagcctctcc ctgtcttgtg
60aaacctgggc gtgatatacc tcccttttag ggctgctgcg atcatttagg cagattaaac
120ctcataagtg gtttcccata caagaaagat gctagcagtg caacagacag
aacacttacc 180tgcctgccct cccgccagga ggtggtcttc caacttttgc
ccggagtcta cagagggtgg 240gccctctctg ctggggctcc gggacatggt
caggagaggt tggtctgtct gtaccgccat 300tctcttggcc agactgtggt
gtctggtccc tactcacacc ttcctgtcag agtatccaga 360ggccgcagag
tatccacacc ctggctgggt gtactggcta cagatggctg tggctccagg
420tcacctgcgt gcctgggtga tgagaaataa tgtcacaaca aatatcccat
ctgcattctc 480tgggacactg acccatgaag agaaagcagt tctcacagtt
tttacaggca cagccacagc 540cgtgcatgta caggtggcag ctttagcttc
tgctaaactg gagagctcag tgtttgtgac 600agactgcgtg tcctgcaaaa
tcgaaaatgt ctgtgattca gctcttcagg gaaaaagggt 660gccgatgtct
ggcctacagg gctcaagcat tgtcatcatg cccccatcca accgtccact
720cgccagtgcg gcatcctgca cgtggtcagt ccaagtccag ggagggcccc
atcacctggg 780ggtggtcgct atcagtggca aagtcttgtc agcagctcat
ggggcaggaa gggcctatgg 840ttgggggttt cctggcgatc ccatggagga
aggatacaag accctcctga aaggaatttc 900cgggaagttc aatagtggtg
agttggtggc cattatgggt ccttccgggg ccgggaagtc 960cacgctgatg
aacatcctgg ctggatacag ggagacgggc atgaaggggg ccgtcctcat
1020caacggcctg ccccgggacc tgcgctgctt ccggaaggtg tcctgctaca
tcatgcagga 1080tgacatgctg ctgccgcatc tcactgtgca ggaggccatg
atggtgtcgg cacatctgaa 1140gcttcaggag aaggatgaag gcagaaggga
aatggtcaag gagatactga cagcgctggg 1200cttgctgtct tgcgccaaca
cgcggaccgg gagcctgtca ggtggtcagc gcaagcgcct 1260ggccatcgcg
ctggagctgg tgaacaaccc tccagtcatg ttcttcgatg agcccaccag
1320cggcctggac agcgcctcct gcttccaggt ggtctcgctg atgaaagggc
tcgctcaagg 1380gggtcgctcc atcatttgca ccatccacca gcccagcgcc
aaactcttcg agctgttcga 1440ccagctttac gtcctgagtc aaggacaatg
tgtgtaccgg ggaaaagtct gcaatcttgt 1500gccatatttg agggatttgg
gtctgaactg cccaacctac cacaacccag cagattttgt 1560catggaggtt
gcatccggcg agtacggtga tcagaacagt cggctggtga gagcggttcg
1620ggagggcatg tgtgactcag accacaagag agacctcggg ggtgatgccg
aggtgaaccc 1680ttttctttgg caccggccct ctgaagaggt aaagcagaca
aaacgattaa aggggttgag 1740aaaggactcc tcgtccatgg aaggctgcca
cagcttctct gccagctgcc tcacgcagtt 1800ctgcatcctc ttcaagagga
ccttcctcag catcatgagg gactcggtcc tgacacacct 1860gcgcatcacc
tcgcacattg ggatcggcct cctcattggc ctgctgtact tggggatcgg
1920gaacgaagcc aagaaggtct tgagcaactc cggcttcctc ttcttctcca
tgctgttcct 1980catgttcgcg gccctcatgc ctactgttct gacatttccc
ctggagatgg gagtctttct 2040tcgggaacac ctgaactact ggtacagcct
gaaggcctac tacctggcca agaccatggc 2100agacgtgccc tttcagatca
tgttcccagt ggcctactgc agcatcgtgt actggatgac 2160gtcgcagccg
tccgacgccg tgcgctttgt gctgtttgcc gcgctgggca ccatgacctc
2220cctggtggca cagtccctgg gcctgctgat cggagccgcc tccacgtccc
tgcaggtggc 2280cactttcgtg ggcccagtga cagccatccc ggtgctcctg
ttctcggggt tcttcgtcag 2340cttcgacacc atccccacgt acctacagtg
gatgtcctac atctcctatg tcaggtatgg 2400gttcgaaggg gtcatcctct
ccatctatgg cttagaccgg gaagatctgc actgtgacat 2460cgacgagacg
tgccacttcc agaagtcgga ggccatcctg cgggagctgg acgtggaaaa
2520tgccaagctg tacctggact tcatcgtact cgggattttc ttcatctccc
tccgcctcat 2580tgcctatttt gtcctcaggt acaaaatccg ggcagagagg
taaaacacct gaatgccagg 2640aaacaggaag attagacact gtggccgagg
gcacgtctag aatcgaggag gcaagcctgt 2700gcccgaccga cgacacagag
actcttctga tccaacccct agaaccgcgt tgggtttgtg 2760ggtgtctcgt
gctcagccac tctgcccagc tgggttggat cttctctcca ttcccctttc
2820tagctttaac taggaagatg taggcagatt ggtggttttt ttttttttaa
catacagaat 2880tttaaatacc acaactgggg cagaatttaa agctgcaaca
cagctggtga tgagaggctt 2940cctcagtcca gtcgctcctt agcaccaggc
accgtgggtc ctggatgggg aactgcaagc 3000agcctctcag ctgatggctg
cacagtcaga tgtctggtgg cagagagtcc gagcatggag 3060cgattccatt
ttatgactgt tgtttttcac attttcatct ttctaaggtg tgtctctttt
3120ccaatgagaa gtcatttttg caagccaaaa gtcgatcaat cgcattcatt
ttaagaaatt
3180ataccttttt agtacttgct gaagaatgat tcagggtaaa tcacatactt
tgtttagaga 3240ggcgaggggt ttaaccgagt cacccagctg gtctcataca
tagacagcac ttgtgaagga 3300ttgaatgcag gttccaggtg gagggaagac
gtggacacca tctccactga gccatgcaga 3360catttttaaa agctatacaa
aaaattgtga gaagacattg gccaactctt tcaaagtctt 3420tctttttcca
cgtgcttctt attttaagcg aaatatattg tttgtttctt cctaaaaaaa
3480aaaaaaaaaa aaaaaaaa 3498223400DNAHomo sapiens 22ggaaccgccg
ccggtatccg cgtccgcagc gccgccagcc aggcgagagc cgtgtgggat 60cccagcgccc
gcactcccgc ccccgccaag gagccaggaa tggcacaact agagaggagc
120gccatctctg gcttcagctc taagtccagg cgaaactcat tcgcatatga
tgttaagcgt 180gaagtataca atgaggagac ctttcaacag gaacacaaaa
ggaaggcctc ctcttctggg 240aacatgaaca tcaacatcac caccttcaga
caccacgtcc agtgccgctg ctcatggcac 300aggttcctac gatgcgtgct
tacaatcttt cccttcctag aatggatgtg tatgtatcga 360ttaaaggatt
ggcttctggg agacttactt gctggtataa gtgttggcct tgtgcaagtt
420ccccaaggcc tgacacttag tttgctggca aggcaactga ttcctcctct
caacatcgct 480tatgcagctt tctgttcttc ggtaatctat gtaatttttg
gatcgtgtca tcaaatgtcc 540attggttcct tcttcctggt gagtgctctg
ctgatcaacg ttctgaaagt gagcccattc 600aacaacggtc aactggtcat
gggatctttc gtcaagaatg agttttcggc cccctcctac 660cttatgggct
ataataaatc cttgagtgtg gtggcaacca caacttttct gactgggatt
720attcagctaa taatgggcgt attgggtttg ggcttcattg ccacttacct
tccggagtct 780gcaatgagtg cttacctggc tgctgtggca cttcatatca
tgctgtccca gctgactttc 840atctttggga ttatgattag tttccatgcc
ggtcccatct ccttcttcta tgacataatt 900aattactgtg tagctctccc
aaaagcgaat tccaccagca ttctagtatt tctaactgtt 960gttgttgctc
tgcgaatcaa caaatgtatc agaatttctt tcaatcagta tcccattgag
1020tttcccatgg aattatttct gattattggc ttcactgtga ttgcaaacaa
gataagcatg 1080gccacagaaa ccagccagac gcttattgac atgattcctt
atagctttct gcttcctgta 1140acaccagatt tcagccttct tcccaagata
attttacaag ccttctcctt atctttggtg 1200agctcctttc tgctcatatt
tctgggcaag aagattgcca gtcttcacaa ttacagtgtc 1260aattccaacc
aggatttaat agccatcggc ctttgcaatg tcgtcagttc atttttcaga
1320tcttgtgtgt ttactggtgc tattgctagg actattatcc aggataaatc
tggaggaaga 1380caacagtttg catctctggt aggcgcaggt gtgatgctgc
tcctgatggt gaagatggga 1440cactttttct acacactgcc aaatgctgtg
ctggctggta ttattctgag caacgtcatt 1500ccctaccttg aaaccatttc
taacctaccc agcctgtgga ggcaggacca atatgactgt 1560gctctttgga
tgatgacatt ctcatcttca attttcctgg gactggacat tggactaatt
1620atctcagtag tttctgcttt cttcatcacc actgttcgtt cacacagagc
taagattctt 1680ctcctgggtc aaatccctaa caccaacatt tatagaagca
tcaatgatta tcgggagatc 1740atcaccattc ctggggtgaa aatcttccag
tgctgcagct caattacatt tgtaaatgtt 1800tactacctaa agcataagct
gttaaaagag gttgatatgg taaaggtgcc tcttaaagaa 1860gaagaaattt
tcagcttgtt taattcaagt gacaccaatc tacaaggagg aaagatttgc
1920aggtgtttct gcaactgtga tgatctggag ccgctgccca ggattcttta
cacagagcga 1980tttgaaaata aactggatcc cgaagcatcc tccattaacc
tgattcactg ctcacatttt 2040gagagcatga acacaagcca aactgcatcc
gaagaccaag tgccatacac agtatcgtcc 2100gtgtctcaga aaaatcaagg
gcaacagtat gaggaggtgg aggaagtttg gcttcctaat 2160aactcatcaa
gaaacagctc accaggactg cctgatgtgg cggaaagcca ggggaggaga
2220tcactcatcc cttactcaga tgcgtctcta ctgcccagtg tccacaccat
catcctggat 2280ttctccatgg tacactacgt ggattcacgg gggttagtcg
tattaagaca gatatgcaat 2340gcctttcaaa acgccaacat tttgatactc
attgcagggt gtcactcttc catagtcagg 2400gcatttgaga ggaatgattt
ctttgacgct ggcatcacca agacccagct gttcctcagc 2460gttcacgacg
ccgtgctgtt tgccttgtca aggaaggtca taggctcctc tgagttaagc
2520atcgatgaat ccgagacagt gatacgggaa acctactcag aaacagacaa
gaatgacaat 2580tcaagatata aaatgagcag cagttttcta ggaagccaaa
aaaatgtaag tccaggcttc 2640atcaagatcc aacagcctgt agaagaggag
tcggagttgg atttggagct ggaatcagaa 2700caagaggctg ggctgggtct
ggacctagac ctggatcggg agctggagcc tgaaatggag 2760cccaaggctg
agaccgagac caagacccag accgagatgg agccccagcc tgagactgag
2820cctgagatgg agcccaaccc caaatctagg ccaagagctc acacttttcc
tcagcagcgt 2880tactggccta tgtatcatcc gtctatggct tccacccagt
ctcagactca gactcggaca 2940tggtcagtgg agaggagacg ccatcctatg
gattcatact caccagaggg caacagcaat 3000gaagatgtct aggagatgaa
ctagaaataa ggggtcagat aatgctggca aatcctccta 3060cccaaaaagg
ggtcaattgt ccagagacct agactggata cgaactagca gtacttcctt
3120cctgactgtg actcctacta cctgccagcc ttcttccttg ctctgcgctg
ggatcatact 3180cccaaatcac attactaaat gccaacaatt atctctgaat
tccctatcca ggctcccctc 3240atttcacctt cagcatatat tctagtcatg
aatttccttc ttcacacacc ccacatctct 3300gggctttgtg ccagaccatc
tctaacttaa tcctctcatc cctgttcccc tttctccaaa 3360gagatgaagc
tcaaataaaa tgtataactc tagtaaaaaa 340023977DNAHomo sapiens
23attgaatgca gcaagggtct ggaggctgag gaccaggcag acaaacattc agagttgctg
60gaatgcgaca gagacaggga gtcagactgg tcatgcaagg ccagctctgg ggtctcggca
120ggtggtccgc gacatgacct ccgagttctt ctctgcccag ctccgggccc
agatctctga 180cgacaccact cacccgatct cctactacaa gcccgagttc
tacatgccgg atgacggggg 240cactgctcac ctgtctgtgg tcgcagagga
cggcagtgct gtgtccgcca ccagcaccat 300caacctctac tttggctcca
aggtgcgctc cccagtcagc gggatcctgc tcaataatga 360aatggatgac
ttcagctcta ccagcatcac caacgagttt ggggtacccc cctcacctgc
420caatttcatc cagccaggga agcagccgct ctcgtccatg tgcccgacga
tcatggtggg 480ccaggacggc caggtccgga tggtggtggg agctgccggg
ggcacgcaga tcaccatggc 540cactgcactg gccatcatct acaacctctg
gttcggctat gacgtgaagt gggccgtgga 600ggagccccgg ctgcacaacc
agcttctgcc caacgtcacg acagtggaga gaaacattga 660ccaggaagtg
actgcagccc tggagacccg gcaccatcac acccagatca cgtccacctt
720cattgctgtg gtgcaagcca tcgtccgcat ggctggtggc tgggcagctg
cctcggactc 780caggaaaggt ggggaacctg ctggctactg attgctccag
gcggacaagg ctgacaagca 840atccaggaac aaaatactca ccaggacgag
gaagaggact ttgggggaca ggcttctcct 900gtgagcagca gagcagcaca
ataaatgagg ccactgtgcc aggctccagg tggcctccct 960ggcctgtctc cccactc
977241049DNAHomo sapiens 24ctcgagagct gggctctgcg tcctcgtcca
gccgccaact cggccaaagg cgaagccagc 60agtttcttct gctgccgggc aacgcgcctt
ttaaacctga gggagtgggc gcgtgagcac 120ttaatggcgc cggtgacaga
gtgagcttaa cggattaata agcgcagcca ggccagctct 180ggggtctcgg
caggtggtcc gcgacatgac ctccgagttc ttctctgccc agctccgggc
240ccagatctct gacgacacca ctcacccgat ctcctactac aagcccgagt
tctacatgcc 300ggatgacggg ggcactgctc acctgtctgt ggtcgcagag
gacggcagtg ctgtgtccgc 360caccagcacc atcaacctct actttggctc
caaggtgcgc tccccagtca gcgggatcct 420gctcaataat gaaatggatg
acttcagctc taccagcatc accaacgagt ttggggtacc 480cccctcacct
gccaatttca tccagccagg gaagcagccg ctctcgtcca tgtgcccgac
540gatcatggtg ggccaggacg gccaggtccg gatggtggtg ggagctgccg
ggggcacgca 600gatcaccatg gccactgcac tggccatcat ctacaacctc
tggttcggct atgacgtgaa 660gtgggccgtg gaggagcccc ggctgcacaa
ccagcttctg cccaacgtca cgacagtgga 720gagaaacatt gaccaggaag
tgactgcagc cctggagacc cggcaccatc acacccagat 780cacgtccacc
ttcattgctg tggtgcaagc catcgtccgc atggctggtg gctgggcagc
840tgcctcggac tccaggaaag gtggggaacc tgctggctac tgattgctcc
aggcggacaa 900ggctgacaag caatccagga acaaaatact caccaggacg
aggaagagga ctttggggga 960caggcttctc ctgtgagcag cagagcagca
caataaatga ggccactgtg ccaggctcca 1020ggtggcctcc ctggcctgtc
tccccactc 1049251108DNAHomo sapiens 25attgaatgca gcaagggtct
ggaggctgag gaccaggcag acaaacattc agagttgctg 60gaatgcgaca gagacaggga
gtcagactgg tcatgcaagg tcctgggcct gcccttgggt 120cctggggagc
cacggaaggt tgtgggtgcc agagggttgt ggtcagagcc acagtcaggg
180gccttctgag acctgtgccc cctccccacc ctccctcccc acctccctag
gccagctctg 240gggtctcggc aggtggtccg cgacatgacc tccgagttct
tctctgccca gctccgggcc 300cagatctctg acgacaccac tcacccgatc
tcctactaca agcccgagtt ctacatgccg 360gatgacgggg gcactgctca
cctgtctgtg gtcgcagagg acggcagtgc tgtgtccgcc 420accagcacca
tcaacctcta ctttggctcc aaggtgcgct ccccagtcag cgggatcctg
480ctcaataatg aaatggatga cttcagctct accagcatca ccaacgagtt
tggggtaccc 540ccctcacctg ccaatttcat ccagccaggg aagcagccgc
tctcgtccat gtgcccgacg 600atcatggtgg gccaggacgg ccaggtccgg
atggtggtgg gagctgccgg gggcacgcag 660atcaccatgg ccactgcact
ggccatcatc tacaacctct ggttcggcta tgacgtgaag 720tgggccgtgg
aggagccccg gctgcacaac cagcttctgc ccaacgtcac gacagtggag
780agaaacattg accaggaagt gactgcagcc ctggagaccc ggcaccatca
cacccagatc 840acgtccacct tcattgctgt ggtgcaagcc atcgtccgca
tggctggtgg ctgggcagct 900gcctcggact ccaggaaagg tggggaacct
gctggctact gattgctcca ggcggacaag 960gctgacaagc aatccaggaa
caaaatactc accaggacga ggaagaggac tttgggggac 1020aggcttctcc
tgtgagcagc agagcagcac aataaatgag gccactgtgc caggctccag
1080gtggcctccc tggcctgtct ccccactc 1108262414DNAHomo sapiens
26gtcagagtct tccctcagct ttgtacatca gcactgtttt gatagataag agaggctact
60gtataagtgt gtaagatttg taatggactg aggaatgctt gttctagctg ctgaaactga
120ctgtaactgt attgtcttag gagcatcatc atggggtcta gtgccacaga
gattgaagaa 180ttggaaaaca ccacttttaa gtatcttaca ggagaacaga
ctgaaaaaat gtggcagcgc 240ctgaaaggaa tactaagatg cttggtgaag
cagctggaaa gaggtgatgt taacgtcgtc 300gacttaaaga agaatattga
atatgcggca tctgtgctgg aagcagttta tatcgatgaa 360acaagaagac
ttctggatac tgaagatgag ctcagtgaca ttcagactga ctcagtccca
420tctgaagtcc gggactggtt ggcttctacc tttacacgga aaatggggat
gacaaaaaag 480aaacctgagg aaaaaccaaa atttcggagc attgtgcatg
ctgttcaagc tggaattttt 540gtggaaagaa tgtaccgaaa aacatatcat
atggttggtt tggcatatcc agcagctgtc 600atcgtaacat taaaggatgt
tgataaatgg tctttcgatg tatttgccct aaatgaagca 660agtggagagc
atagtctgaa gtttatgatt tatgaactgt ttaccagata tgatcttatc
720aaccgtttca agattcctgt ttcttgccta atcacctttg cagaagcttt
agaagttggt 780tacagcaagt acaaaaatcc atatcacaat ttgattcatg
cagctgatgt cactcaaact 840gtgcattaca taatgcttca tacaggtatc
atgcactggc tcactgaact ggaaatttta 900gcaatggtct ttgctgctgc
cattcatgat tatgagcata cagggacaac aaacaacttt 960cacattcaga
caaggtcaga tgttgccatt ttgtataatg atcgctctgt ccttgagaat
1020caccacgtga gtgcagctta tcgacttatg caagaagaag aaatgaatat
cttgataaat 1080ttatccaaag atgactggag ggatcttcgg aacctagtga
ttgaaatggt tttatctaca 1140gacatgtcag gtcacttcca gcaaattaaa
aatataagaa acagtttgca gcagcctgaa 1200gggattgaca gagccaaaac
catgtccctg attctccacg cagcagacat cagccaccca 1260gccaaatcct
ggaagctgca ttatcggtgg accatggccc taatggagga gtttttcctg
1320cagggagata aagaagctga attagggctt ccattttccc cactttgtga
tcggaagtca 1380accatggtgg cccagtcaca aataggtttc atcgatttca
tagtagagcc aacattttct 1440cttctgacag actcaacaga gaaaattgtt
attcctctta tagaggaagc ctcaaaagcc 1500gaaacttctt cctatgtggc
aagcagctca accaccattg tggggttaca cattgctgat 1560gcactaagac
gatcaaatac aaaaggctcc atgagtgatg ggtcctattc cccagactac
1620tcccttgcag cagtggacct gaagagtttc aagaacaacc tggtggacat
cattcagcag 1680aacaaagaga ggtggaaaga gttagctgca caaggtgaat
ctgatcttca taagaactca 1740gaagacttag taaatgctga agaaaaacat
gatgagacac attcataggc ccgaaacacc 1800ttaaagactt ctgtcatttt
aaacatgaga ggacaatgaa atcagcatga aaacatccta 1860aattctcaac
tttccacaaa gctatggctc ttctttcaac atagaattgg attgggccat
1920tttaattgac tcctatacaa ggaattaaga agaacataaa ttttgagcta
gtaactctgg 1980ccaaataaat acactcaagt ttttatcaga gtttttggcc
agtgcttctg ccattttttt 2040ccctccacaa tttggccttc ttcaatcaag
ccagataaat ttttgagaca aaagtcagac 2100agtttttaat ttttcttgct
ttgaaccctg tcataatgac tgtgcaatac atgtgcagaa 2160gatgaggtat
tttaaaattt acttccttgc actgtcttac acagagtgct ataactataa
2220atttttcaag gtcttaaata aaaggaagca aaaacaaaat tattgaaaaa
ttttttttgt 2280tgtgctgggg aatatactat ttagattgtc cttcttattt
taaatgcatg ggaacagaat 2340gacagggggg atgctgagga gctggttgaa
gcatcagagc aatgctacag tccaacaatg 2400gagcattaga tccc
2414272009DNAHomo sapiens 27gaattctgat gtgcttcagt gcacagaaca
gtaacagatg agctgctttt ggggagagct 60tgagtactca gtcggagcat catcatgggg
tctagtgcca cagagattga agaattggaa 120aacaccactt ttaagtatct
tacaggagaa cagactgaaa aaatgtggca gcgcctgaaa 180ggaatactaa
gatgcttggt gaagcagctg gaaagaggtg atgttaacgt cgtcgactta
240aagaagaata ttgaatatgc ggcatctgtg ctggaagcag tttatatcga
tgaaacaaga 300agacttctgg atactgaaga tgagctcagt gacattcaga
ctgactcagt cccatctgaa 360gtccgggact ggttggcttc tacctttaca
cggaaaatgg ggatgacaaa aaagaaacct 420gaggaaaaac caaaatttcg
gagcattgtg catgctgttc aagctggaat ttttgtggaa 480agaatgtacc
gaaaaacata tcatatggtt ggtttggcat atccagcagc tgtcatcgta
540acattaaagg atgttgataa atggtctttc gatgtatttg ccctaaatga
agcaagtgga 600gagcatagtc tgaagtttat gatttatgaa ctgtttacca
gatatgatct tatcaaccgt 660ttcaagattc ctgtttcttg cctaatcacc
tttgcagaag ctttagaagt tggttacagc 720aagtacaaaa atccatatca
caatttgatt catgcagctg atgtcactca aactgtgcat 780tacataatgc
ttcatacagg tatcatgcac tggctcactg aactggaaat tttagcaatg
840gtctttgctg ctgccattca tgattatgag catacaggga caacaaacaa
ctttcacatt 900cagacaaggt cagatgttgc cattttgtat aatgatcgct
ctgtccttga gaatcaccac 960gtgagtgcag cttatcgact tatgcaagaa
gaagaaatga atatcttgat aaatttatcc 1020aaagatgact ggagggatct
tcggaaccta gtgattgaaa tggttttatc tacagacatg 1080tcaggtcact
tccagcaaat taaaaatata agaaacagtt tgcagcagcc tgaagggatt
1140gacagagcca aaaccatgtc cctgattctc cacgcagcag acatcagcca
cccagccaaa 1200tcctggaagc tgcattatcg gtggaccatg gccctaatgg
aggagttttt cctgcaggga 1260gataaagaag ctgaattagg gcttccattt
tccccacttt gtgatcggaa gtcaaccatg 1320gtggcccagt cacaaatagg
tttcatcgat ttcatagtag agccaacatt ttctcttctg 1380acagactcaa
cagagaaaat tgttattcct cttatagagg aagcctcaaa agccgaaact
1440tcttcctatg tggcaagcag ctcaaccacc attgtggggt tacacattgc
tgatgcacta 1500agacgatcaa atacaaaagg ctccatgagt gatgggtcct
attccccaga ctactccctt 1560gcagcagtgg acctgaagag tttcaagaac
aacctggtgg acatcattca gcagaacaaa 1620gagaggtgga aagagttagc
tgcacaagaa gcaagaacca gttcacagaa gtgtgagttt 1680attcatcagt
aaacaccttt aagtaaaacc tcgtgcatgg tggcagctct aatttgacca
1740aaagacttgg agattttgat tatgcttgct ggaaatctac cctgtcctgt
gtgagacagg 1800aaatctattt ttgcagattg ctcaataagc atcatgagcc
acataaataa cagctgtaaa 1860ctccttaatt caccgggctc aactgctacc
gaacagattc atctagtggc tacatcagca 1920ccttgtgctt tcagatatct
gtttcaatgg cattttgtgg catttgtctt taccgagtgc 1980caataaattt
tctttgagca gctaaaaaa 2009282846DNAHomo sapiens 28aaatgcttga
ggagagagag agagtaagga gccagccatg aatcctttcc agaaaaatga 60gtccaaggaa
actctttttt cacctgtctc cattgaagag gtaccacctc gaccacctag
120ccctccaaag aagccatctc cgacaatctg tggctccaac tatccactga
gcattgcctt 180cattgtggtg aatgaattct gcgagcgctt ttcctattat
ggaatgaaag ctgtgctgat 240cctgtatttc ctgtatttcc tgcactggaa
tgaagatacc tccacatcta tataccatgc 300cttcagcagc ctctgttatt
ttactcccat cctgggagca gccattgctg actcgtggtt 360gggaaaattc
aagacaatca tctatctctc cttggtgtat gtgcttggcc atgtgatcaa
420gtccttgggt gccttaccaa tactgggagg acaagtggta cacacagtcc
tatcattgat 480cggcctgagt ctaatagctt tggggacagg aggcatcaaa
ccctgtgtgg cagcttttgg 540tggagaccag tttgaagaaa aacatgcaga
ggaacggact agatacttct cagtcttcta 600cctgtccatc aatgcaggga
gcttgatttc tacatttatc acacccatgc tgagaggaga 660tgtgcaatgt
tttggagaag actgctatgc attggctttt ggagttccag gactgctcat
720ggtaattgca cttgttgtgt ttgcaatggg aagcaaaata tacaataaac
caccccctga 780aggaaacata gtggctcaag ttttcaaatg tatctggttt
gctatttcca atcgtttcaa 840gaaccgttct ggagacattc caaagcgaca
gcactggcta gactgggcgg ctgagaaata 900tccaaagcag ctcattatgg
atgtaaaggc actgaccagg gtactattcc tttatatccc 960attgcccatg
ttctgggctc ttttggatca gcagggttca cgatggactt tgcaagccat
1020caggatgaat aggaatttgg ggttttttgt gcttcagccg gaccagatgc
aggttctaaa 1080tccccttctg gttcttatct tcatcccgtt gtttgacttt
gtcatttatc gtctggtctc 1140caagtgtgga attaacttct catcacttag
gaaaatggct gttggtatga tcctagcatg 1200cctggcattt gcagttgcgg
cagctgtaga gataaaaata aatgaaatgg ccccagccca 1260gccaggtccc
caggaggttt tcctacaagt cttgaatctg gcagatgatg aggtgaaggt
1320gacagtggtg ggaaatgaaa acaattctct gttgatagag tccatcaaat
cctttcagaa 1380aacaccacac tattccaaac tgcacctgaa aacaaaaagc
caggattttc acttccacct 1440gaaatatcac aatttgtctc tctacactga
gcattctgtg caggagaaga actggtacag 1500tcttgtcatt cgtgaagatg
ggaacagtat ctccagcatg atggtaaagg atacagaaag 1560cagaacaacc
aatgggatga caaccgtgag gtttgttaac actttgcata aagatgtcaa
1620catctccctg agtacagata cctctctcaa tgttggtgaa gactatggtg
tgtctgctta 1680tagaactgtg caaagaggag aataccctgc agtgcactgt
agaacagaag ataagaactt 1740ttctctgaat ttgggtcttc tagactttgg
tgcagcatat ctgtttgtta ttactaataa 1800caccaatcag ggtcttcagg
cctggaagat tgaagacatt ccagccaaca aaatgtccat 1860tgcgtggcag
ctaccacaat atgccctggt tacagctggg gaggtcatgt tctctgtcac
1920aggtcttgag ttttcttatt ctcaggctcc ctctggcatg aaatctgtgc
tccaggcagc 1980ttggctattg acaattgcag ttgggaatat catcgtgctt
gttgtggcac agttcagtgg 2040cctggtacag tgggccgaat tcattttgtt
ttcctgcctc ctgctggtga tctgcctgat 2100cttctccatc atgggctact
actatgttcc tgtaaagaca gaggatatgc ggggtccagc 2160agataagcac
attcctcaca tccaggggaa catgatcaaa ctagagacca agaagacaaa
2220actctgatga ctccctagat tctgtcctga ccccaattcc tggccctgtc
ttgaagcatt 2280ttttttcttc tactggatta gacaagagag atagcagcat
atcagagctg atctcctcca 2340cctttctcca atgacagaag ttccaggact
ggttttccag tacatcttta aacaaggccc 2400cagagactct atgtctgccc
gtccatcagt gaactcatta aaacttgtgc agtgttgctg 2460gagctggcct
ggtgtctcca aatgaccatg aaaatacaca cgtataatgg agatcattct
2520ctgtgggtat gcaaagttat gggaattcct ttataggtaa ctgccattta
ggactgatgg 2580ccctaatttt tgaggtgctg atttagaggc aaaattgcag
aataacaaag aaatggtatt 2640tcaagttttt ttttttataa gcaatgtaat
tatgctattc acaggggcct caagaattgg 2700tatgtatgat gtgatctggt
ccagccaggg cctggcttgt cagctctcta ggtttgatat 2760gactttagta
aatttgtcaa tatagatggt aggaagcaga atgccatttt attaaaacac
2820aggagaagtt aaaaaaaaaa aaaaaa 28462921DNAArtificial
SequenceSynthetic oligonucleotide 29ccgtttacgt ggagactcgc c
213025DNAArtificial SequenceSynthetic oligonucleotide 30cccccacctt
atatatattc tttcc 253119DNAArtificial SequenceSynthetic
oligonucleotide 31ccatgcctat ttctacagc 193219DNAArtificial
SequenceSynthetic oligonucleotide 32tcagtaacag ctcccagac
193319DNAArtificial SequenceSynthetic oligonucleotide
33ccatgcctat
ttctacagc 193419DNAArtificial SequenceSynthetic oligonucleotide
34tcagtaacag ctcccagac 193522DNAArtificial SequenceSynthetic
oligonucleotide 35ggcaatagca ggttcacgta ca 223622DNAArtificial
SequenceSynthetic oligonucleotide 36cgataacagt cttgccccac tt
223720DNAArtificial SequenceSynthetic oligonucleotide 37acggcacacc
ctacgttacc 203824DNAArtificial SequenceSynthetic oligonucleotide
38tgtgcaagga gagaacctct agct 243919DNAArtificial SequenceSynthetic
oligonucleotide 39ccaacactgt gcgcagctt 194022DNAArtificial
SequenceSynthetic oligonucleotide 40aagaatctcc gggttgtttt cc
224124DNAArtificial SequenceSynthetic oligonucleotide 41cagtctcatc
ctgaaagcat ctga 244220DNAArtificial SequenceSynthetic
oligonucleotide 42tttcccacac actccaccaa 204323DNAArtificial
SequenceSynthetic oligonucleotide 43tggagtgttt tacgctgaac gat
234431DNAArtificial SequenceSynthetic oligonucleotide 44cctcttactg
ctataccttt actctttatg g 314521DNAArtificial SequenceSynthetic
oligonucleotide 45tgccatcaaa gtcttctgca a 214621DNAArtificial
SequenceSynthetic oligonucleotide 46cgccatactc gaactggaat c
214725DNAArtificial SequenceSynthetic oligonucleotide 47cactattatt
ttggcacaac aggaa 254824DNAArtificial SequenceSynthetic
oligonucleotide 48agacacatat ttggcatggt tctg 244924DNAArtificial
SequenceSynthetic oligonucleotide 49caagggatcc agtctctcta tggt
245024DNAArtificial SequenceSynthetic oligonucleotide 50ggataaggaa
gggtcacatt tgtc 245118DNAArtificial SequenceSynthetic
oligonucleotide 51gctcggtgga gggtctca 185221DNAArtificial
SequenceSynthetic oligonucleotide 52ctgtgtggat ttctgcgatc a
215323DNAArtificial SequenceSynthetic oligonucleotide 53catccatgac
aactttggta tcg 235421DNAArtificial SequenceSynthetic
oligonucleotide 54agtcttctgg gtggcagtga t 2155919PRTHomo sapiens
55Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp 1
5 10 15 Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu
Val 20 25 30 Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe
Thr Arg Glu 35 40 45 Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr
Pro Ser Gln Lys Asn 50 55 60 Arg Arg Lys Lys Arg Arg Ile Ser Tyr
Val Gln Asp Glu Asn Arg Asp 65 70 75 80 Pro Ile Arg Arg Arg Leu Ser
Arg Arg Lys Ser Arg Ser Ser Gln Leu 85 90 95 Ser Ser Arg Arg Leu
Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr 100 105 110 Val Val Gly
Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala 115 120 125 Ala
Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro 130 135
140 Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His
145 150 155 160 Thr Gln Cys Gln Leu Val Pro Val Val Glu Ile Gly Ile
Ser Glu Arg 165 170 175 Gln Asn Ala Glu Gln His Val Thr Gln Leu Met
Ser Thr Glu Pro Leu 180 185 190 Pro Arg Thr Leu Ser Pro Thr Pro Ala
Ser Ala Thr Ala Pro Thr Ser 195 200 205 Gln Gly Ile Pro Thr Ser Asp
Glu Glu Ser Thr Pro Lys Lys Ser Lys 210 215 220 Ala Arg Ile Leu Glu
Ser Ile Thr Val Ser Ser Leu Met Ala Thr Pro 225 230 235 240 Gln Asp
Pro Lys Gly Gln Gly Val Gly Thr Gly Arg Ser Ala Ser Lys 245 250 255
Leu Arg Ile Ala Gln Val Ser Pro Gly Pro Arg Asp Ser Pro Ala Phe 260
265 270 Pro Asp Ser Pro Trp Arg Glu Arg Val Leu Ala Pro Ile Leu Pro
Asp 275 280 285 Asn Phe Ser Thr Pro Thr Gly Ser Arg Thr Asp Ser Gln
Ser Val Arg 290 295 300 His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro
Gln Val Leu Ala Gln 305 310 315 320 Lys Tyr Ser Leu Val Ala Lys Gln
Glu Ser Val Val Arg Arg Ala Ser 325 330 335 Arg Arg Leu Ala Lys Lys
Thr Ala Glu Glu Pro Ala Ala Ser Gly Arg 340 345 350 Ile Ile Cys His
Ser Tyr Leu Glu Arg Leu Leu Asn Val Glu Val Pro 355 360 365 Gln Lys
Val Gly Ser Glu Gln Lys Glu Pro Pro Glu Glu Ala Glu Pro 370 375 380
Val Ala Ala Ala Glu Pro Glu Val Pro Glu Asn Asn Gly Asn Asn Ser 385
390 395 400 Trp Pro His Asn Asp Thr Glu Ile Ala Asn Ser Thr Pro Asn
Pro Lys 405 410 415 Pro Ala Ala Ser Ser Pro Glu Thr Pro Ser Ala Gly
Gln Gln Glu Ala 420 425 430 Lys Thr Asp Gln Ala Asp Gly Pro Arg Glu
Pro Pro Gln Ser Ala Arg 435 440 445 Arg Lys Arg Ser Tyr Lys Gln Ala
Val Ser Glu Leu Asp Glu Glu Gln 450 455 460 His Leu Glu Asp Glu Glu
Leu Gln Pro Pro Arg Ser Lys Thr Pro Ser 465 470 475 480 Ser Pro Cys
Pro Ala Ser Lys Val Val Arg Pro Leu Arg Thr Phe Leu 485 490 495 His
Thr Val Gln Arg Asn Gln Met Leu Met Thr Pro Thr Ser Ala Pro 500 505
510 Arg Ser Val Met Lys Ser Phe Ile Lys Arg Asn Thr Pro Leu Arg Met
515 520 525 Asp Pro Lys Glu Lys Glu Arg Gln Arg Leu Glu Asn Leu Arg
Arg Lys 530 535 540 Glu Glu Ala Glu Gln Leu Arg Arg Gln Lys Val Glu
Glu Asp Lys Arg 545 550 555 560 Arg Arg Leu Glu Glu Val Lys Leu Lys
Arg Glu Glu Arg Leu Arg Lys 565 570 575 Val Leu Gln Ala Arg Glu Arg
Val Glu Gln Met Lys Glu Glu Lys Lys 580 585 590 Lys Gln Ile Glu Gln
Lys Phe Ala Gln Ile Asp Glu Lys Thr Glu Lys 595 600 605 Ala Lys Glu
Glu Arg Leu Ala Glu Glu Lys Ala Lys Lys Lys Ala Ala 610 615 620 Ala
Lys Lys Met Glu Glu Val Glu Ala Arg Arg Lys Gln Glu Glu Asp 625 630
635 640 Ala Arg Arg Leu Arg Trp Leu Gln Gln Glu Glu Glu Glu Arg Arg
His 645 650 655 Gln Glu Leu Leu Gln Lys Lys Lys Glu Glu Glu Gln Glu
Arg Leu Arg 660 665 670 Lys Ala Ala Glu Ala Lys Arg Leu Ala Glu Gln
Arg Glu Gln Glu Arg 675 680 685 Arg Glu Gln Glu Arg Arg Glu Gln Glu
Arg Arg Glu Gln Glu Arg Arg 690 695 700 Glu Gln Glu Arg Arg Glu Gln
Glu Arg Arg Glu Gln Glu Arg Gln Leu 705 710 715 720 Ala Glu Gln Glu
Arg Arg Arg Glu Gln Glu Arg Leu Gln Ala Glu Arg 725 730 735 Glu Leu
Gln Glu Arg Glu Lys Ala Leu Arg Leu Gln Lys Glu Gln Leu 740 745 750
Gln Arg Glu Leu Glu Glu Lys Lys Lys Lys Glu Glu Gln Gln Arg Leu 755
760 765 Ala Glu Arg Gln Leu Gln Glu Glu Gln Glu Lys Lys Ala Lys Glu
Ala 770 775 780 Ala Gly Ala Ser Lys Ala Leu Asn Val Thr Val Asp Val
Gln Ser Pro 785 790 795 800 Ala Cys Thr Ser Ser Pro Ile Thr Pro Gln
Gly His Lys Ala Pro Pro 805 810 815 Gln Ile Asn Pro His Asn Tyr Gly
Met Asp Leu Asn Ser Asp Asp Ser 820 825 830 Thr Asp Asp Glu Ala His
Pro Arg Lys Pro Ile Pro Thr Trp Ala Arg 835 840 845 Gly Thr Pro Leu
Ser Gln Ala Ile Ile His Gln Tyr Tyr Gln Pro Pro 850 855 860 Asn Leu
Leu Glu Leu Phe Gly Thr Ile Leu Pro Leu Asp Leu Glu Asp 865 870 875
880 Ile Phe Lys Lys Ser Lys Pro Arg Tyr His Lys Arg Thr Ser Ser Ala
885 890 895 Val Trp Asn Ser Pro Pro Leu Gln Gly Ala Arg Val Pro Ser
Ser Leu 900 905 910 Ala Tyr Ser Leu Lys Lys His 915 56804PRTHomo
sapiens 56Met Thr Asn Gln Glu Lys Trp Ala His Leu Ser Pro Ser Glu
Phe Ser 1 5 10 15 Gln Leu Gln Lys Tyr Ala Glu Tyr Ser Thr Lys Lys
Leu Lys Asp Val 20 25 30 Leu Glu Glu Phe His Gly Asn Gly Val Leu
Ala Lys Tyr Asn Pro Glu 35 40 45 Gly Lys Gln Asp Ile Leu Asn Gln
Thr Ile Asp Phe Glu Gly Phe Lys 50 55 60 Leu Phe Met Lys Thr Phe
Leu Glu Ala Glu Leu Pro Asp Asp Phe Thr 65 70 75 80 Ala His Leu Phe
Met Ser Phe Ser Asn Lys Phe Pro His Ser Ser Pro 85 90 95 Met Val
Lys Ser Lys Pro Ala Leu Leu Ser Gly Gly Leu Arg Met Asn 100 105 110
Lys Gly Ala Ile Thr Pro Pro Arg Thr Thr Ser Pro Ala Asn Thr Cys 115
120 125 Ser Pro Glu Val Ile His Leu Lys Asp Ile Val Cys Tyr Leu Ser
Leu 130 135 140 Leu Glu Arg Gly Arg Pro Glu Asp Lys Leu Glu Phe Met
Phe Arg Leu 145 150 155 160 Tyr Asp Thr Asp Gly Asn Gly Phe Leu Asp
Ser Ser Glu Leu Glu Asn 165 170 175 Ile Ile Ser Gln Met Met His Val
Ala Glu Tyr Leu Glu Trp Asp Val 180 185 190 Thr Glu Leu Asn Pro Ile
Leu His Glu Met Met Glu Glu Ile Asp Tyr 195 200 205 Asp His Asp Gly
Thr Val Ser Leu Glu Glu Trp Ile Gln Gly Gly Met 210 215 220 Thr Thr
Ile Pro Leu Leu Val Leu Leu Gly Leu Glu Asn Asn Val Lys 225 230 235
240 Asp Asp Gly Gln His Val Trp Arg Leu Lys His Phe Asn Lys Pro Ala
245 250 255 Tyr Cys Asn Leu Cys Leu Asn Met Leu Ile Gly Val Gly Lys
Gln Gly 260 265 270 Leu Cys Cys Ser Phe Cys Lys Tyr Thr Val His Glu
Arg Cys Val Ala 275 280 285 Arg Ala Pro Pro Ser Cys Ile Lys Thr Tyr
Val Lys Ser Lys Arg Asn 290 295 300 Thr Asp Val Met His His Tyr Trp
Val Glu Gly Asn Cys Pro Thr Lys 305 310 315 320 Cys Asp Lys Cys His
Lys Thr Val Lys Cys Tyr Gln Gly Leu Thr Gly 325 330 335 Leu His Cys
Val Trp Cys Gln Ile Thr Leu His Asn Lys Cys Ala Ser 340 345 350 His
Leu Lys Pro Glu Cys Asp Cys Gly Pro Leu Lys Asp His Ile Leu 355 360
365 Pro Pro Thr Thr Ile Cys Pro Val Val Leu Gln Thr Leu Pro Thr Ser
370 375 380 Gly Val Ser Val Pro Glu Glu Arg Gln Ser Thr Val Lys Lys
Glu Lys 385 390 395 400 Ser Gly Ser Gln Gln Pro Asn Lys Val Ile Asp
Lys Asn Lys Met Gln 405 410 415 Arg Ala Asn Ser Val Thr Val Asp Gly
Gln Gly Leu Gln Val Thr Pro 420 425 430 Val Pro Gly Thr His Pro Leu
Leu Val Phe Val Asn Pro Lys Ser Gly 435 440 445 Gly Lys Gln Gly Glu
Arg Ile Tyr Arg Lys Phe Gln Tyr Leu Leu Asn 450 455 460 Pro Arg Gln
Val Tyr Ser Leu Ser Gly Asn Gly Pro Met Pro Gly Leu 465 470 475 480
Asn Phe Phe Arg Asp Val Pro Asp Phe Arg Val Leu Ala Cys Gly Gly 485
490 495 Asp Gly Thr Val Gly Trp Val Leu Asp Cys Ile Glu Lys Ala Asn
Val 500 505 510 Gly Lys His Pro Pro Val Ala Ile Leu Pro Leu Gly Thr
Gly Asn Asp 515 520 525 Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr
Glu Gly Glu Asn Leu 530 535 540 Met Lys Ile Leu Lys Asp Ile Glu Asn
Ser Thr Glu Ile Met Leu Asp 545 550 555 560 Arg Trp Lys Phe Glu Val
Ile Pro Asn Asp Lys Asp Glu Lys Gly Asp 565 570 575 Pro Val Pro Tyr
Ser Ile Ile Asn Asn Tyr Phe Ser Ile Gly Val Asp 580 585 590 Ala Ser
Ile Ala His Arg Phe His Ile Met Arg Glu Lys His Pro Glu 595 600 605
Lys Phe Asn Ser Arg Met Lys Asn Lys Phe Trp Tyr Phe Glu Phe Gly 610
615 620 Thr Ser Glu Thr Phe Ser Ala Thr Cys Lys Lys Leu His Glu Ser
Val 625 630 635 640 Glu Ile Glu Cys Asp Gly Val Gln Ile Asp Leu Ile
Asn Ile Ser Leu 645 650 655 Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser
Met His Gly Gly Ser Asn 660 665 670 Leu Trp Gly Glu Ser Lys Lys Arg
Arg Ser His Arg Arg Ile Glu Lys 675 680 685 Lys Gly Ser Asp Lys Arg
Thr Thr Val Thr Asp Ala Lys Glu Leu Lys 690 695 700 Phe Ala Ser Gln
Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu 705 710 715 720 Glu
Gly Ala Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala 725 730
735 Gly Arg Arg Leu Ala Gln Cys Ser Cys Val Val Ile Arg Thr Ser Lys
740 745 750 Ser Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln Thr
Pro Cys 755 760 765 Thr Ile Lys Ile Thr His Lys Asn Gln Ala Pro Met
Leu Met Gly Pro 770 775 780 Pro Pro Lys Thr Gly Leu Phe Cys Ser Leu
Val Lys Arg Thr Arg Asn 785 790 795 800 Arg Ser Lys Glu
57773PRTHomo sapiens 57Met Thr Asn Gln Glu Lys Trp Ala His Leu Ser
Pro Ser Glu Phe Ser 1 5 10 15 Gln Leu Gln Lys Tyr Ala Glu Tyr Ser
Thr Lys Lys Leu Lys Asp Val 20 25 30 Leu Glu Glu Phe His Gly Asn
Gly Val Leu Ala Lys Tyr Asn Pro Glu 35 40 45 Gly Lys Gln Asp Ile
Leu Asn Gln Thr Ile Asp Phe Glu Gly Phe Lys 50 55 60 Leu Phe Met
Lys Thr Phe Leu Glu Ala Glu Leu Pro Asp Asp Phe Thr 65 70 75 80 Ala
His Leu Phe Met Ser Phe Ser Asn Lys Phe Pro His Ser Ser Pro 85 90
95 Met Val Lys Ser Lys Pro Ala Leu Leu Ser Gly Gly Leu Arg Met Asn
100 105 110 Lys Gly Ala Ile Thr Pro Pro Arg Thr Thr Ser Pro Ala Asn
Thr Cys 115 120 125 Ser Pro Glu Val Ile His Leu Lys Asp Ile Val Cys
Tyr Leu Ser Leu 130 135 140 Leu Glu Arg Gly Arg Pro Glu Asp Lys Leu
Glu Phe Met Phe Arg Leu 145 150 155 160 Tyr Asp Thr Asp Gly Asn Gly
Phe Leu Asp Ser Ser Glu Leu Glu Asn 165 170 175 Ile Ile Ser Gln Met
Met His Val Ala Glu Tyr Leu Glu Trp Asp Val
180 185 190 Thr Glu Leu Asn Pro Ile Leu His Glu Met Met Glu Glu Ile
Asp Tyr 195 200 205 Asp His Asp Gly Thr Val Ser Leu Glu Glu Trp Ile
Gln Gly Gly Met 210 215 220 Thr Thr Ile Pro Leu Leu Val Leu Leu Gly
Leu Glu Asn Asn Val Lys 225 230 235 240 Asp Asp Gly Gln His Val Trp
Arg Leu Lys His Phe Asn Lys Pro Ala 245 250 255 Tyr Cys Asn Leu Cys
Leu Asn Met Leu Ile Gly Val Gly Lys Gln Gly 260 265 270 Leu Cys Cys
Ser Phe Cys Lys Tyr Thr Val His Glu Arg Cys Val Ala 275 280 285 Arg
Ala Pro Pro Ser Cys Ile Lys Thr Tyr Val Lys Ser Lys Arg Asn 290 295
300 Thr Asp Val Met His His Tyr Trp Val Glu Gly Asn Cys Pro Thr Lys
305 310 315 320 Cys Asp Lys Cys His Lys Thr Val Lys Cys Tyr Gln Gly
Leu Thr Gly 325 330 335 Leu His Cys Val Trp Cys Gln Ile Thr Leu His
Asn Lys Cys Ala Ser 340 345 350 His Leu Lys Pro Glu Cys Asp Cys Gly
Pro Leu Lys Asp His Ile Leu 355 360 365 Pro Pro Thr Thr Ile Cys Pro
Val Val Leu Gln Thr Leu Pro Thr Ser 370 375 380 Gly Val Ser Val Pro
Glu Glu Arg Gln Ser Thr Val Lys Lys Glu Lys 385 390 395 400 Ser Gly
Ser Gln Gln Pro Asn Lys Val Ile Asp Lys Asn Lys Met Gln 405 410 415
Arg Ala Asn Ser Val Thr Val Asp Gly Gln Gly Leu Gln Val Thr Pro 420
425 430 Val Pro Gly Thr His Pro Leu Leu Val Phe Val Asn Pro Lys Ser
Gly 435 440 445 Gly Lys Gln Gly Glu Arg Ile Tyr Arg Lys Phe Gln Tyr
Leu Leu Asn 450 455 460 Pro Arg Gln Val Tyr Ser Leu Ser Gly Asn Gly
Pro Met Pro Gly Leu 465 470 475 480 Asn Phe Phe Arg Asp Val Pro Asp
Phe Arg Val Leu Ala Cys Gly Gly 485 490 495 Asp Gly Thr Val Gly Trp
Val Leu Asp Cys Ile Glu Lys Ala Asn Val 500 505 510 Gly Lys His Pro
Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp 515 520 525 Leu Ala
Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Glu Asn Leu 530 535 540
Met Lys Ile Leu Lys Asp Ile Glu Asn Ser Thr Glu Ile Met Leu Asp 545
550 555 560 Arg Trp Lys Phe Glu Val Ile Pro Asn Asp Lys Asp Glu Lys
Gly Asp 565 570 575 Pro Val Pro Tyr Ser Ile Ile Asn Asn Tyr Phe Ser
Ile Gly Val Asp 580 585 590 Ala Ser Ile Ala His Arg Phe His Ile Met
Arg Glu Lys His Pro Glu 595 600 605 Lys Phe Asn Ser Arg Met Lys Asn
Lys Phe Trp Tyr Phe Glu Phe Gly 610 615 620 Thr Ser Glu Thr Phe Ser
Ala Thr Cys Lys Lys Leu His Glu Ser Val 625 630 635 640 Glu Ile Glu
Cys Asp Gly Val Gln Ile Asp Leu Ile Asn Ile Ser Leu 645 650 655 Glu
Gly Ile Ala Ile Leu Asn Ile Pro Ser Met His Gly Gly Ser Asn 660 665
670 Leu Trp Gly Glu Ser Lys Lys Arg Arg Ser His Arg Arg Ile Glu Lys
675 680 685 Lys Gly Ser Asp Lys Arg Thr Thr Val Thr Asp Ala Lys Glu
Leu Lys 690 695 700 Phe Ala Ser Gln Asp Leu Ser Asp Gln Leu Leu Glu
Val Val Gly Leu 705 710 715 720 Glu Gly Ala Met Glu Met Gly Gln Ile
Tyr Thr Gly Leu Lys Ser Ala 725 730 735 Gly Arg Arg Leu Ala Gln Cys
Ser Cys Val Val Ile Arg Thr Ser Lys 740 745 750 Ser Leu Pro Met Gln
Ile Asp Gly Glu Pro Trp Met Gln Thr Pro Cys 755 760 765 Thr Val Ser
Thr Glu 770 58632PRTHomo sapiens 58Met Asn Arg Tyr Thr Thr Ile Arg
Gln Leu Gly Asp Gly Thr Tyr Gly 1 5 10 15 Ser Val Leu Leu Gly Arg
Ser Ile Glu Ser Gly Glu Leu Ile Ala Ile 20 25 30 Lys Lys Met Lys
Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 35 40 45 Arg Glu
Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys 50 55 60
Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 65
70 75 80 Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn
Lys Leu 85 90 95 Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln
Ile Leu Gln Gly 100 105 110 Leu Ala Phe Ile His Lys His Gly Phe Phe
His Arg Asp Leu Lys Pro 115 120 125 Glu Asn Leu Leu Cys Met Gly Pro
Glu Leu Val Lys Ile Ala Asp Phe 130 135 140 Gly Leu Ala Arg Glu Ile
Arg Ser Lys Pro Pro Tyr Thr Asp Tyr Val 145 150 155 160 Ser Thr Arg
Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 165 170 175 Tyr
Ser Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 180 185
190 Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr
195 200 205 Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr
Asp Trp 210 215 220 Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe
Arg Trp Pro Gln 225 230 235 240 Cys Val Pro Asn Asn Leu Lys Thr Leu
Ile Pro Asn Ala Ser Ser Glu 245 250 255 Ala Val Gln Leu Leu Arg Asp
Met Leu Gln Trp Asp Pro Lys Lys Arg 260 265 270 Pro Thr Ala Ser Gln
Ala Leu Arg Tyr Pro Tyr Phe Gln Val Gly His 275 280 285 Pro Leu Gly
Ser Thr Thr Gln Asn Leu Gln Asp Ser Glu Lys Pro Gln 290 295 300 Lys
Gly Ile Leu Glu Lys Ala Gly Pro Pro Pro Tyr Ile Lys Pro Val 305 310
315 320 Pro Pro Ala Gln Pro Pro Ala Lys Pro His Thr Arg Ile Ser Ser
Arg 325 330 335 Gln His Gln Ala Ser Gln Pro Pro Leu His Leu Thr Tyr
Pro Tyr Lys 340 345 350 Ala Glu Val Ser Arg Thr Asp His Pro Ser His
Leu Gln Glu Asp Lys 355 360 365 Pro Ser Pro Leu Leu Phe Pro Ser Leu
His Asn Lys His Pro Gln Ser 370 375 380 Lys Ile Thr Ala Gly Leu Glu
His Lys Asn Gly Glu Ile Lys Pro Lys 385 390 395 400 Ser Arg Arg Arg
Trp Gly Leu Ile Ser Arg Ser Thr Lys Asp Ser Asp 405 410 415 Asp Trp
Ala Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg 420 425 430
Ile Asp Leu Lys Asn Lys Lys Arg Gln Ser Asp Asp Thr Leu Cys Arg 435
440 445 Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr
Gly 450 455 460 Asn Ser Ala Pro Thr Gln Thr Ser Tyr Gln Arg Arg Asp
Thr Pro Thr 465 470 475 480 Leu Arg Ser Ala Ala Lys Gln His Tyr Leu
Lys His Ser Arg Tyr Leu 485 490 495 Pro Gly Ile Ser Ile Arg Asn Gly
Ile Leu Ser Asn Pro Gly Lys Glu 500 505 510 Phe Ile Pro Pro Asn Pro
Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser 515 520 525 Ser Gly Thr Met
Ser Val Ile Ser Lys Val Asn Ser Val Gly Ser Ser 530 535 540 Ser Thr
Ser Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 545 550 555
560 Lys Lys Glu Ile Gly Ser Ala Met Gln Arg Val His Leu Ala Pro Ile
565 570 575 Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg
Pro His 580 585 590 Pro Gly Arg Pro Phe Phe His Thr Gln Pro Arg Ser
Thr Pro Gly Leu 595 600 605 Ile Pro Arg Pro Pro Ala Ala Gln Pro Val
His Gly Arg Thr Asp Trp 610 615 620 Ala Ser Lys Tyr Ala Ser Arg Arg
625 630 59632PRTHomo sapiens 59Met Asn Arg Tyr Thr Thr Ile Arg Gln
Leu Gly Asp Gly Thr Tyr Gly 1 5 10 15 Ser Val Leu Leu Gly Arg Ser
Ile Glu Ser Gly Glu Leu Ile Ala Ile 20 25 30 Lys Lys Met Lys Arg
Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 35 40 45 Arg Glu Val
Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys 50 55 60 Leu
Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 65 70
75 80 Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn Lys
Leu 85 90 95 Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln Ile
Leu Gln Gly 100 105 110 Leu Ala Phe Ile His Lys His Gly Phe Phe His
Arg Asp Leu Lys Pro 115 120 125 Glu Asn Leu Leu Cys Met Gly Pro Glu
Leu Val Lys Ile Ala Asp Phe 130 135 140 Gly Leu Ala Arg Glu Ile Arg
Ser Lys Pro Pro Tyr Thr Asp Tyr Val 145 150 155 160 Ser Thr Arg Trp
Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 165 170 175 Tyr Ser
Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 180 185 190
Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr 195
200 205 Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr Asp
Trp 210 215 220 Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe Arg
Trp Pro Gln 225 230 235 240 Cys Val Pro Asn Asn Leu Lys Thr Leu Ile
Pro Asn Ala Ser Ser Glu 245 250 255 Ala Val Gln Leu Leu Arg Asp Met
Leu Gln Trp Asp Pro Lys Lys Arg 260 265 270 Pro Thr Ala Ser Gln Ala
Leu Arg Tyr Pro Tyr Phe Gln Val Gly His 275 280 285 Pro Leu Gly Ser
Thr Thr Gln Asn Leu Gln Asp Ser Glu Lys Pro Gln 290 295 300 Lys Gly
Ile Leu Glu Lys Ala Gly Pro Pro Pro Tyr Ile Lys Pro Val 305 310 315
320 Pro Pro Ala Gln Pro Pro Ala Lys Pro His Thr Arg Ile Ser Ser Arg
325 330 335 Gln His Gln Ala Ser Gln Pro Pro Leu His Leu Thr Tyr Pro
Tyr Lys 340 345 350 Ala Glu Val Ser Arg Thr Asp His Pro Ser His Leu
Gln Glu Asp Lys 355 360 365 Pro Ser Pro Leu Leu Phe Pro Ser Leu His
Asn Lys His Pro Gln Ser 370 375 380 Lys Ile Thr Ala Gly Leu Glu His
Lys Asn Gly Glu Ile Lys Pro Lys 385 390 395 400 Ser Arg Arg Arg Trp
Gly Leu Ile Ser Arg Ser Thr Lys Asp Ser Asp 405 410 415 Asp Trp Ala
Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg 420 425 430 Ile
Asp Leu Lys Asn Lys Lys Arg Gln Ser Asp Asp Thr Leu Cys Arg 435 440
445 Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly
450 455 460 Asn Ser Ala Pro Thr Gln Thr Ser Tyr Gln Arg Arg Asp Thr
Pro Thr 465 470 475 480 Leu Arg Ser Ala Ala Lys Gln His Tyr Leu Lys
His Ser Arg Tyr Leu 485 490 495 Pro Gly Ile Ser Ile Arg Asn Gly Ile
Leu Ser Asn Pro Gly Lys Glu 500 505 510 Phe Ile Pro Pro Asn Pro Trp
Ser Ser Ser Gly Leu Ser Gly Lys Ser 515 520 525 Ser Gly Thr Met Ser
Val Ile Ser Lys Val Asn Ser Val Gly Ser Ser 530 535 540 Ser Thr Ser
Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 545 550 555 560
Lys Lys Glu Ile Gly Ser Ala Met Gln Arg Val His Leu Ala Pro Ile 565
570 575 Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg Pro
His 580 585 590 Pro Gly Arg Pro Phe Phe His Thr Gln Pro Arg Ser Thr
Pro Gly Leu 595 600 605 Ile Pro Arg Pro Pro Ala Ala Gln Pro Val His
Gly Arg Thr Asp Trp 610 615 620 Ala Ser Lys Tyr Ala Ser Arg Arg 625
630 60455PRTHomo sapiens 60Met Ile Cys Cys Ser Ala Leu Ser Pro Arg
Ile His Leu Ser Phe His 1 5 10 15 Arg Ser Leu Thr Gly Ile Val Leu
Ala Asn Ser Ser Leu Asp Ile Val 20 25 30 Leu His Asp Thr Tyr Tyr
Val Val Ala His Cys Gly Gly Asn Val Arg 35 40 45 Arg Leu His Cys
Gly Gly Pro Ala Ser Arg Glu Arg Thr Ala Met Gln 50 55 60 Ala Leu
Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg Asp His 65 70 75 80
Asn Leu Thr Arg Glu Gln Phe Ile Ala Leu Tyr Arg Leu Arg Pro Leu 85
90 95 Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu Ala Leu Val
Leu 100 105 110 Thr Gly Val Leu Ile Phe Ala Leu Ala Leu Phe Gly Asn
Ala Leu Val 115 120 125 Phe Tyr Val Val Thr Arg Ser Lys Ala Met Arg
Thr Val Thr Asn Ile 130 135 140 Phe Ile Cys Ser Leu Ala Leu Ser Asp
Leu Leu Ile Thr Phe Phe Cys 145 150 155 160 Ile Pro Val Thr Met Leu
Gln Asn Ile Ser Asp Asn Trp Leu Gly Gly 165 170 175 Ala Phe Ile Cys
Lys Met Val Pro Phe Val Gln Ser Thr Ala Val Val 180 185 190 Thr Glu
Ile Leu Thr Met Thr Cys Ile Ala Val Glu Arg His Gln Gly 195 200 205
Leu Val His Pro Phe Lys Met Lys Trp Gln Tyr Thr Asn Arg Arg Ala 210
215 220 Phe Thr Met Leu Gly Val Val Trp Leu Val Ala Val Ile Val Gly
Ser 225 230 235 240 Pro Met Trp His Val Gln Gln Leu Glu Ile Lys Tyr
Asp Phe Leu Tyr 245 250 255 Glu Lys Glu His Ile Cys Cys Leu Glu Glu
Trp Thr Ser Pro Val His 260 265 270 Gln Lys Ile Tyr Thr Thr Phe Ile
Leu Ser Ser Ser Ser Ser Cys Leu 275 280 285 Leu Trp Lys Lys Lys Arg
Ala Val Ile Met Met Val Thr Val Val Ala 290 295 300 Leu Phe Ala Val
Cys Trp Ala Pro Phe His Val Val His Met Met Ile 305 310 315 320 Glu
Tyr Ser Asn Phe Glu Lys Glu Tyr Asp Asp Val Thr Ile Lys Met 325 330
335 Ile Phe Ala Ile Val Gln Ile Ile Gly Phe Ser Asn Ser Ile Cys Asn
340 345 350 Pro Ile Val Tyr Ala Phe Met Asn Glu Asn Phe Lys Lys Asn
Val Leu 355 360 365 Ser Ala Val Cys Tyr Cys Ile Val Asn Lys Thr Phe
Ser Pro Ala Gln 370 375 380 Arg His Gly Asn Ser Gly Ile Thr Met Met
Arg Lys Lys Ala Lys Phe 385 390 395 400 Ser Leu Arg Glu Asn Pro Val
Glu Glu Thr Lys Gly Glu Ala Phe Ser 405 410 415 Asp Gly Asn Ile Glu
Val Lys Leu Cys Glu Gln Thr Glu Glu Lys Lys 420 425 430 Lys Leu Lys
Arg His Leu Ala Leu Phe Arg Ser Glu Leu Ala Glu Asn 435 440
445 Ser Pro Leu Asp Ser Gly His 450 455 61431PRTHomo sapiens 61Met
Gln Ala Leu Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg 1 5 10
15 Asp His Asn Leu Thr Arg Glu Gln Phe Ile Ala Val His Arg Leu Arg
20 25 30 Pro Leu Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu
Ala Leu 35 40 45 Val Leu Thr Gly Val Leu Ile Phe Ala Leu Ala Leu
Phe Gly Asn Ala 50 55 60 Leu Val Phe Tyr Val Val Thr Arg Ser Lys
Ala Met Arg Thr Val Thr 65 70 75 80 Asn Ile Phe Ile Cys Ser Leu Ala
Leu Ser Asp Leu Leu Ile Thr Phe 85 90 95 Phe Cys Ile Pro Val Thr
Met Leu Gln Asn Ile Ser Asp Asn Trp Leu 100 105 110 Gly Gly Ala Phe
Ile Cys Lys Met Val Pro Phe Val Gln Ser Thr Ala 115 120 125 Val Val
Thr Glu Ile Leu Thr Met Thr Cys Ile Ala Val Glu Arg His 130 135 140
Gln Gly Leu Val His Pro Phe Lys Met Lys Trp Gln Tyr Thr Asn Arg 145
150 155 160 Arg Ala Phe Thr Met Leu Gly Val Val Trp Leu Val Ala Val
Ile Val 165 170 175 Gly Ser Pro Met Trp His Val Gln Gln Leu Glu Ile
Lys Tyr Asp Phe 180 185 190 Leu Tyr Glu Lys Glu His Ile Cys Cys Leu
Glu Glu Trp Thr Ser Pro 195 200 205 Val His Gln Lys Ile Tyr Thr Thr
Phe Ile Leu Val Ile Leu Phe Leu 210 215 220 Leu Pro Leu Met Val Met
Leu Ile Leu Tyr Ser Lys Ile Gly Tyr Glu 225 230 235 240 Leu Trp Ile
Lys Lys Arg Val Gly Asp Gly Ser Val Leu Arg Thr Ile 245 250 255 His
Gly Lys Glu Met Ser Lys Ile Ala Arg Lys Lys Lys Arg Ala Val 260 265
270 Ile Met Met Val Thr Val Val Ala Leu Phe Ala Val Cys Trp Ala Pro
275 280 285 Phe His Val Val His Met Met Ile Glu Tyr Ser Asn Phe Glu
Lys Glu 290 295 300 Tyr Asp Asp Val Thr Ile Lys Met Ile Phe Ala Ile
Val Gln Ile Ile 305 310 315 320 Gly Phe Ser Asn Ser Ile Cys Asn Pro
Ile Val Tyr Ala Phe Met Asn 325 330 335 Glu Asn Phe Lys Lys Asn Val
Leu Ser Ala Val Cys Tyr Cys Ile Val 340 345 350 Asn Lys Thr Phe Ser
Pro Ala Gln Arg His Gly Asn Ser Gly Ile Thr 355 360 365 Met Met Arg
Lys Lys Ala Lys Phe Ser Leu Arg Glu Asn Pro Val Glu 370 375 380 Glu
Thr Lys Gly Glu Ala Phe Ser Asp Gly Asn Ile Glu Val Lys Leu 385 390
395 400 Cys Glu Gln Thr Glu Glu Lys Lys Lys Leu Lys Arg His Leu Ala
Leu 405 410 415 Phe Arg Ser Glu Leu Ala Glu Asn Ser Pro Leu Asp Ser
Gly His 420 425 430 62647PRTHomo sapiens 62Met Ala Glu Glu Glu Ala
Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly 1 5 10 15 Ala Ser Trp Glu
Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu 20 25 30 Glu Gly
Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro 35 40 45
Arg Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala 50
55 60 Pro Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro
Gly 65 70 75 80 Gln Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro
Gln Gln Gln 85 90 95 Gln Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly
Ile Ser Val Pro Asp 100 105 110 His Gly Tyr Cys Gln Pro Ile Ser Ile
Pro Leu Cys Thr Asp Ile Ala 115 120 125 Tyr Asn Gln Thr Ile Met Pro
Asn Leu Leu Gly His Thr Asn Gln Glu 130 135 140 Asp Ala Gly Leu Glu
Val His Gln Phe Tyr Pro Leu Val Lys Val Gln 145 150 155 160 Cys Ser
Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val 165 170 175
Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu 180
185 190 Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe
Gln 195 200 205 Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His
Gly Ala Gly 210 215 220 Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys
Gly Thr Pro Thr Pro 225 230 235 240 Ser Leu Leu Pro Glu Phe Trp Thr
Ser Asn Pro Gln His Gly Gly Gly 245 250 255 Gly His Arg Gly Gly Phe
Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly 260 265 270 Lys Phe Ser Cys
Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr 275 280 285 His Phe
Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys 290 295 300
Val Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 305
310 315 320 Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr
Leu Phe 325 330 335 Thr Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe
Ser Tyr Pro Glu 340 345 350 Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr
Thr Ala Val Ala Val Ala 355 360 365 Tyr Ile Ala Gly Phe Leu Leu Glu
Asp Arg Val Val Cys Asn Asp Lys 370 375 380 Phe Ala Glu Asp Gly Ala
Arg Thr Val Ala Gln Gly Thr Lys Lys Glu 385 390 395 400 Gly Cys Thr
Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser 405 410 415 Ser
Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly 420 425
430 Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His
435 440 445 Leu Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile
Leu Ala 450 455 460 Leu Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val
Cys Phe Val Gly 465 470 475 480 Leu Asn Asn Val Asp Ala Leu Arg Gly
Phe Val Leu Ala Pro Leu Phe 485 490 495 Val Tyr Leu Phe Ile Gly Thr
Ser Phe Leu Leu Ala Gly Phe Val Ser 500 505 510 Leu Phe Arg Ile Arg
Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu 515 520 525 Lys Leu Glu
Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr 530 535 540 Thr
Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala 545 550
555 560 Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys
Ser 565 570 575 Tyr Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly
Ala Pro Pro 580 585 590 His Pro Pro Met Ser Pro Asp Phe Thr Val Phe
Met Ile Lys Tyr Leu 595 600 605 Met Thr Leu Ile Val Gly Ile Thr Ser
Gly Phe Trp Ile Trp Ser Gly 610 615 620 Lys Thr Leu Asn Ser Trp Arg
Lys Phe Tyr Thr Arg Leu Thr Asn Ser 625 630 635 640 Lys Gln Gly Glu
Thr Thr Val 645 63258PRTHomo sapiens 63Met Leu Val Leu Tyr Gly His
Ser Thr Gln Asp Leu Pro Glu Thr Asn 1 5 10 15 Ala Arg Val Val Gly
Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 20 25 30 Gln Ile Ser
Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys 35 40 45 Gly
Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 50 55
60 Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu
65 70 75 80 Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys
Ile Val 85 90 95 Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala
Gly Tyr Asp Ile 100 105 110 Ala Leu Leu Arg Leu Ala Gln Ser Val Thr
Leu Asn Ser Tyr Val Gln 115 120 125 Leu Gly Val Leu Pro Gln Glu Gly
Ala Ile Leu Ala Asn Asn Ser Pro 130 135 140 Cys Tyr Ile Thr Gly Trp
Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 145 150 155 160 Gln Thr Leu
Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 165 170 175 Ser
Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 180 185
190 Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly
195 200 205 Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly
Val Thr 210 215 220 Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg
Lys Pro Thr Val 225 230 235 240 Phe Thr Gln Val Ser Ala Tyr Ile Ser
Trp Ile Asn Asn Val Ile Ala 245 250 255 Ser Asn 642555PRTHomo
sapiens 64Met Thr Ala Ile Thr His Gly Ser Pro Val Gly Gly Asn Asp
Ser Gln 1 5 10 15 Gly Gln Val Leu Asp Gly Gln Ser Gln His Leu Phe
Gln Gln Asn Gln 20 25 30 Thr Ser Ser Pro Asp Ser Ser Asn Glu Asn
Ser Val Ala Thr Pro Pro 35 40 45 Pro Glu Glu Gln Gly Gln Gly Asp
Ala Pro Pro Gln His Glu Asp Glu 50 55 60 Glu Pro Ala Phe Pro His
Thr Glu Leu Ala Asn Leu Asp Asp Met Ile 65 70 75 80 Asn Arg Pro Arg
Trp Val Val Pro Val Leu Pro Lys Gly Glu Leu Glu 85 90 95 Val Leu
Leu Glu Ala Ala Ile Asp Leu Ser Val Lys Gly Leu Asp Val 100 105 110
Lys Ser Glu Ala Cys Gln Arg Phe Phe Arg Asp Gly Leu Thr Ile Ser 115
120 125 Phe Thr Lys Ile Leu Met Asp Glu Ala Val Ser Gly Trp Lys Phe
Glu 130 135 140 Ile His Arg Cys Ile Ile Asn Asn Thr His Arg Leu Val
Glu Leu Cys 145 150 155 160 Val Ala Lys Leu Ser Gln Asp Trp Phe Pro
Leu Leu Glu Leu Leu Ala 165 170 175 Met Ala Leu Asn Pro His Cys Lys
Phe His Ile Tyr Asn Gly Thr Arg 180 185 190 Pro Cys Glu Leu Ile Ser
Ser Asn Ala Gln Leu Pro Glu Glu Glu Leu 195 200 205 Phe Ala Arg Ser
Ser Asp Pro Arg Ser Pro Lys Gly Trp Leu Val Asp 210 215 220 Leu Ile
Asn Lys Phe Gly Thr Leu Asn Gly Phe Gln Ile Leu His Asp 225 230 235
240 Arg Phe Phe Asn Gly Ser Ala Leu Asn Ile Gln Ile Ile Ala Ala Leu
245 250 255 Ile Lys Pro Phe Gly Gln Cys Tyr Glu Phe Leu Ser Gln His
Thr Leu 260 265 270 Lys Lys Tyr Phe Ile Pro Val Ile Glu Ile Val Pro
His Leu Leu Glu 275 280 285 Asn Leu Thr Asp Glu Glu Leu Lys Lys Glu
Ala Lys Asn Glu Ala Lys 290 295 300 Asn Asp Ala Leu Ser Met Ile Ile
Lys Ser Leu Lys Asn Leu Ala Ser 305 310 315 320 Arg Ile Ser Gly Gln
Asp Glu Thr Ile Lys Asn Leu Glu Ile Phe Arg 325 330 335 Leu Lys Met
Ile Leu Arg Leu Leu Gln Ile Ser Ser Phe Asn Gly Lys 340 345 350 Met
Asn Ala Leu Asn Glu Ile Asn Lys Val Ile Ser Ser Val Ser Tyr 355 360
365 Tyr Thr His Arg His Ser Asn Pro Glu Glu Glu Glu Trp Leu Thr Ala
370 375 380 Glu Arg Met Ala Glu Trp Ile Gln Gln Asn Asn Ile Leu Ser
Ile Val 385 390 395 400 Leu Gln Asp Ser Leu His Gln Pro Gln Tyr Val
Glu Lys Leu Glu Lys 405 410 415 Ile Leu Arg Phe Val Ile Lys Glu Lys
Ala Leu Thr Leu Gln Asp Leu 420 425 430 Asp Asn Ile Trp Ala Ala Gln
Ala Gly Lys His Glu Ala Ile Val Lys 435 440 445 Asn Val His Asp Leu
Leu Ala Lys Leu Ala Trp Asp Phe Ser Pro Gly 450 455 460 Gln Leu Asp
His Leu Phe Asp Cys Phe Lys Ala Ser Trp Thr Asn Ala 465 470 475 480
Ser Lys Lys Gln Arg Glu Lys Leu Leu Glu Leu Ile Arg Arg Leu Ala 485
490 495 Glu Asp Asp Lys Asp Gly Val Met Ala His Lys Val Leu Asn Leu
Leu 500 505 510 Trp Asn Leu Ala Gln Ser Asp Asp Val Pro Val Asp Ile
Met Asp Leu 515 520 525 Ala Leu Ser Ala His Ile Lys Ile Leu Asp Tyr
Ser Cys Ser Gln Asp 530 535 540 Arg Asp Ala Gln Lys Ile Gln Trp Ile
Asp His Phe Ile Glu Glu Leu 545 550 555 560 Arg Thr Asn Asp Lys Trp
Val Ile Pro Ala Leu Lys Gln Ile Arg Glu 565 570 575 Ile Cys Ser Leu
Phe Gly Glu Ala Ser Gln Asn Leu Ser Gln Thr Gln 580 585 590 Arg Ser
Pro His Ile Phe Tyr Arg His Asp Leu Ile Asn Gln Leu Gln 595 600 605
Gln Asn His Ala Leu Val Thr Leu Val Ala Glu Asn Leu Ala Thr Tyr 610
615 620 Met Asn Ser Ile Arg Leu Tyr Ala Gly Asp His Glu Asp Tyr Asp
Pro 625 630 635 640 Gln Thr Val Arg Leu Gly Ser Arg Tyr Ser His Val
Gln Glu Val Gln 645 650 655 Glu Arg Leu Asn Phe Leu Arg Phe Leu Leu
Lys Asp Gly Gln Leu Trp 660 665 670 Leu Cys Ala Pro Gln Ala Lys Gln
Ile Trp Lys Cys Leu Ala Glu Asn 675 680 685 Ala Val Tyr Leu Cys Asp
Arg Glu Ala Cys Phe Lys Trp Tyr Ser Lys 690 695 700 Leu Met Gly Asp
Glu Pro Asp Leu Asp Pro Asp Ile Asn Lys Asp Phe 705 710 715 720 Phe
Glu Ser Asn Val Leu Gln Leu Asp Pro Ser Leu Leu Thr Glu Asn 725 730
735 Gly Met Lys Cys Phe Glu Arg Phe Phe Lys Ala Val Asn Cys Arg Glu
740 745 750 Arg Lys Leu Ile Ala Lys Arg Arg Ser Tyr Met Met Asp Asp
Leu Glu 755 760 765 Leu Ile Gly Leu Asp Tyr Leu Trp Arg Val Val Ile
Gln Ser Ser Asp 770 775 780 Glu Ile Ala Asn Arg Ala Ile Asp Leu Leu
Lys Glu Ile Tyr Thr Asn 785 790 795 800 Leu Gly Pro Arg Leu Lys Ala
Asn Gln Val Val Ile His Glu Asp Phe 805 810 815 Ile Gln Ser Cys Phe
Asp Arg Leu Lys Ala Ser Tyr Asp Thr Leu Cys 820 825 830 Val Phe Asp
Gly Asp Lys Asn Ser Ile Asn Cys Ala Arg Gln Glu Ala 835 840 845 Ile
Arg Met Val Arg Val Leu Thr Val Ile Lys Glu Tyr Ile Asn Glu 850 855
860 Cys Asp Ser Asp Tyr His Lys Glu Arg Met Ile Leu Pro Met Ser Arg
865 870 875 880 Ala Phe Cys Gly Lys His Leu Ser Leu Ile Val Arg Phe
Pro Asn Gln 885 890 895 Gly Arg Gln Val Asp Glu Leu Asp Ile Trp Phe
His Thr Asn Asp Thr 900 905 910 Ile Gly Ser Val Arg Arg Cys Ile Val
Asn Arg Ile Lys Ala Asn Val 915 920 925 Ala His Lys Lys Ile Glu Leu
Phe Val Gly Gly Glu Leu Ile Asp Ser 930 935 940 Glu Asn Asp Arg Lys
Leu Ile Gly Gln Leu Asn Leu
Lys Asp Lys Ser 945 950 955 960 Leu Ile Thr Ala Lys Leu Thr Gln Ile
Asn Phe Asn Met Pro Ser Ser 965 970 975 Pro Asp Ser Ser Ser Asp Ser
Ser Thr Ala Ser Pro Gly Asn His Arg 980 985 990 Asn His Tyr Asn Asp
Gly Pro Asn Leu Lys Val Glu Ser Cys Leu Pro 995 1000 1005 Gly Val
Ile Met Ser Val His Pro Lys Tyr Ile Ser Phe Leu Trp 1010 1015 1020
Gln Phe Ala Asn Leu Gly Ser Asn Leu Asn Met Pro Pro Leu Lys 1025
1030 1035 Asn Gly Ala Arg Val Leu Met Lys Leu Met Pro Pro Asp Arg
Thr 1040 1045 1050 Ala Val Glu Lys Leu Arg Thr Val Cys Leu Asp His
Ala Asn Leu 1055 1060 1065 Gly Glu Gly Lys Leu Ser Pro Pro Leu Asp
Ser Leu Phe Phe Gly 1070 1075 1080 Pro Ser Ala Ser Gln Val Leu Tyr
Leu Thr Glu Val Val Tyr Ala 1085 1090 1095 Leu Leu Met Pro Ala Gly
Val Pro Leu Thr Asp Gly Ser Ser Asp 1100 1105 1110 Phe Gln Val His
Phe Leu Lys Ser Gly Gly Leu Pro Leu Val Leu 1115 1120 1125 Ser Met
Leu Ile Arg Asn Asn Phe Leu Pro Asn Thr Asp Met Glu 1130 1135 1140
Thr Arg Arg Gly Ala Tyr Leu Asn Ala Leu Lys Ile Ala Lys Leu 1145
1150 1155 Leu Leu Thr Ala Ile Gly Tyr Gly His Val Arg Ala Val Ala
Glu 1160 1165 1170 Ala Cys Gln Pro Val Val Asp Gly Thr Asp Pro Ile
Thr Gln Ile 1175 1180 1185 Asn Gln Val Thr His Asp Gln Ala Val Val
Leu Gln Ser Ala Leu 1190 1195 1200 Gln Ser Ile Pro Asn Pro Ser Ser
Glu Cys Val Leu Arg Asn Glu 1205 1210 1215 Ser Ile Leu Leu Ala Gln
Glu Ile Ser Asn Glu Ala Ser Arg Tyr 1220 1225 1230 Met Pro Asp Ile
Cys Val Ile Arg Ala Ile Gln Lys Ile Ile Trp 1235 1240 1245 Ala Ser
Ala Cys Gly Ala Leu Gly Leu Phe Phe Ser Pro Asn Glu 1250 1255 1260
Glu Ile Thr Lys Ile Tyr Gln Met Thr Thr Asn Gly Ser Asn Lys 1265
1270 1275 Leu Glu Val Glu Asp Glu Gln Val Cys Cys Glu Ala Leu Glu
Val 1280 1285 1290 Met Thr Leu Cys Phe Ala Leu Leu Pro Thr Ala Leu
Asp Ala Leu 1295 1300 1305 Ser Lys Glu Lys Ala Trp Gln Thr Phe Ile
Ile Asp Leu Leu Leu 1310 1315 1320 His Cys Pro Ser Lys Thr Val Arg
Gln Leu Ala Gln Glu Gln Phe 1325 1330 1335 Phe Leu Met Cys Thr Arg
Cys Cys Met Gly His Arg Pro Leu Leu 1340 1345 1350 Phe Phe Ile Thr
Leu Leu Phe Thr Ile Leu Gly Ser Thr Ala Arg 1355 1360 1365 Glu Lys
Gly Lys Tyr Ser Gly Asp Tyr Phe Thr Leu Leu Arg His 1370 1375 1380
Leu Leu Asn Tyr Ala Tyr Asn Gly Asn Ile Asn Ile Pro Asn Ala 1385
1390 1395 Glu Val Leu Leu Val Ser Glu Ile Asp Trp Leu Lys Arg Ile
Arg 1400 1405 1410 Asp Asn Val Lys Asn Thr Gly Glu Thr Gly Val Glu
Glu Pro Ile 1415 1420 1425 Leu Glu Gly His Leu Gly Val Thr Lys Glu
Leu Leu Ala Phe Gln 1430 1435 1440 Thr Ser Glu Lys Lys Tyr His Phe
Gly Cys Glu Lys Gly Gly Ala 1445 1450 1455 Asn Leu Ile Lys Glu Leu
Ile Asp Asp Phe Ile Phe Pro Ala Ser 1460 1465 1470 Lys Val Tyr Leu
Gln Tyr Leu Arg Ser Gly Glu Leu Pro Ala Glu 1475 1480 1485 Gln Ala
Ile Pro Val Cys Ser Ser Pro Val Thr Ile Asn Ala Gly 1490 1495 1500
Phe Glu Leu Leu Val Ala Leu Ala Ile Gly Cys Val Arg Asn Leu 1505
1510 1515 Lys Gln Ile Val Asp Cys Leu Thr Glu Met Tyr Tyr Met Gly
Thr 1520 1525 1530 Ala Ile Thr Thr Cys Glu Ala Leu Thr Glu Trp Glu
Tyr Leu Pro 1535 1540 1545 Pro Val Gly Pro Arg Pro Pro Lys Gly Phe
Val Gly Leu Lys Asn 1550 1555 1560 Ala Gly Ala Thr Cys Tyr Met Asn
Ser Val Ile Gln Gln Leu Tyr 1565 1570 1575 Met Ile Pro Ser Ile Arg
Asn Ser Ile Leu Ala Ile Glu Gly Thr 1580 1585 1590 Gly Ser Asp Leu
His Asp Asp Met Phe Gly Asp Glu Lys Gln Asp 1595 1600 1605 Ser Glu
Ser Asn Val Asp Pro Arg Asp Asp Val Phe Gly Tyr Pro 1610 1615 1620
His Gln Phe Glu Asp Lys Pro Ala Leu Ser Lys Thr Glu Asp Arg 1625
1630 1635 Lys Glu Tyr Asn Ile Gly Val Leu Arg His Leu Gln Val Ile
Phe 1640 1645 1650 Gly His Leu Ala Ala Ser Gln Leu Gln Tyr Tyr Val
Pro Arg Gly 1655 1660 1665 Phe Trp Lys Gln Phe Arg Leu Trp Gly Glu
Pro Val Asn Leu Arg 1670 1675 1680 Glu Gln His Asp Ala Leu Glu Phe
Phe Asn Ser Leu Val Asp Ser 1685 1690 1695 Leu Asp Glu Ala Leu Lys
Ala Leu Gly His Pro Ala Ile Leu Ser 1700 1705 1710 Lys Val Leu Gly
Gly Ser Phe Ala Asp Gln Lys Ile Cys Gln Gly 1715 1720 1725 Cys Pro
His Arg Phe Glu Cys Glu Glu Ser Phe Thr Thr Leu Asn 1730 1735 1740
Val Asp Ile Arg Asn His Gln Asn Leu Leu Asp Ser Leu Glu Gln 1745
1750 1755 Tyr Ile Lys Gly Asp Leu Leu Glu Gly Ala Asn Ala Tyr His
Cys 1760 1765 1770 Glu Lys Cys Asp Lys Lys Val Asp Thr Val Lys Arg
Leu Leu Ile 1775 1780 1785 Lys Lys Leu Pro Arg Val Leu Ala Ile Gln
Leu Lys Arg Phe Asp 1790 1795 1800 Tyr Asp Trp Glu Arg Glu Cys Ala
Ile Lys Phe Asn Asp Tyr Phe 1805 1810 1815 Glu Phe Pro Arg Glu Leu
Asp Met Gly Pro Tyr Thr Val Ala Gly 1820 1825 1830 Val Ala Asn Leu
Glu Arg Asp Asn Val Asn Ser Glu Asn Glu Leu 1835 1840 1845 Ile Glu
Gln Lys Glu Gln Ser Asp Asn Glu Thr Ala Gly Gly Thr 1850 1855 1860
Lys Tyr Arg Leu Val Gly Val Leu Val His Ser Gly Gln Ala Ser 1865
1870 1875 Gly Gly His Tyr Tyr Ser Tyr Ile Ile Gln Arg Asn Gly Lys
Asp 1880 1885 1890 Asp Gln Thr Asp His Trp Tyr Lys Phe Asp Asp Gly
Asp Val Thr 1895 1900 1905 Glu Cys Lys Met Asp Asp Asp Glu Glu Met
Lys Asn Gln Cys Phe 1910 1915 1920 Gly Gly Glu Tyr Met Gly Glu Val
Phe Asp His Met Met Lys Arg 1925 1930 1935 Met Ser Tyr Arg Arg Gln
Lys Arg Trp Trp Asn Ala Tyr Ile Pro 1940 1945 1950 Phe Tyr Glu Gln
Met Asp Met Ile Asp Glu Asp Asp Glu Met Ile 1955 1960 1965 Arg Tyr
Ile Ser Glu Leu Thr Ile Ala Arg Pro His Gln Ile Ile 1970 1975 1980
Met Ser Pro Ala Ile Glu Arg Ser Val Arg Lys Gln Asn Val Lys 1985
1990 1995 Phe Met His Asn Arg Leu Gln Tyr Ser Leu Glu Tyr Phe Gln
Phe 2000 2005 2010 Val Lys Lys Leu Leu Thr Cys Asn Gly Val Tyr Leu
Asn Pro Ala 2015 2020 2025 Pro Gly Gln Asp Tyr Leu Leu Pro Glu Ala
Glu Glu Ile Thr Met 2030 2035 2040 Ile Ser Ile Gln Leu Ala Ala Arg
Phe Leu Phe Thr Thr Gly Phe 2045 2050 2055 His Thr Lys Lys Ile Val
Arg Gly Pro Ala Ser Asp Trp Tyr Asp 2060 2065 2070 Ala Leu Cys Val
Leu Leu Arg His Ser Lys Asn Val Arg Phe Trp 2075 2080 2085 Phe Thr
His Asn Val Leu Phe Asn Val Ser Asn Arg Phe Ser Glu 2090 2095 2100
Tyr Leu Leu Glu Cys Pro Ser Ala Glu Val Arg Gly Ala Phe Ala 2105
2110 2115 Lys Leu Ile Val Phe Ile Ala His Phe Ser Leu Gln Asp Gly
Ser 2120 2125 2130 Cys Pro Ser Pro Phe Ala Ser Pro Gly Pro Ser Ser
Gln Ala Cys 2135 2140 2145 Asp Asn Leu Ser Leu Ser Asp His Leu Leu
Arg Ala Thr Leu Asn 2150 2155 2160 Leu Leu Arg Arg Glu Val Ser Glu
His Gly His His Leu Gln Gln 2165 2170 2175 Tyr Phe Asn Leu Phe Val
Met Tyr Ala Asn Leu Gly Val Ala Glu 2180 2185 2190 Lys Thr Gln Leu
Leu Lys Leu Asn Val Pro Ala Thr Phe Met Leu 2195 2200 2205 Val Ser
Leu Asp Glu Gly Pro Gly Pro Pro Ile Lys Tyr Gln Tyr 2210 2215 2220
Ala Glu Leu Gly Lys Leu Tyr Ser Val Val Ser Gln Leu Ile Arg 2225
2230 2235 Cys Cys Asn Val Ser Ser Thr Met Gln Ser Ser Ile Asn Gly
Asn 2240 2245 2250 Pro Pro Leu Pro Asn Pro Phe Gly Asp Leu Asn Leu
Ser Gln Pro 2255 2260 2265 Ile Met Pro Ile Gln Gln Asn Val Leu Asp
Ile Leu Phe Val Arg 2270 2275 2280 Thr Ser Tyr Val Lys Lys Ile Ile
Glu Asp Cys Ser Asn Ser Glu 2285 2290 2295 Asp Thr Ile Lys Leu Leu
Arg Phe Cys Ser Trp Glu Asn Pro Gln 2300 2305 2310 Phe Ser Ser Thr
Val Leu Ser Glu Leu Leu Trp Gln Val Ala Tyr 2315 2320 2325 Ser Tyr
Thr Tyr Glu Leu Arg Pro Tyr Leu Asp Leu Leu Phe Gln 2330 2335 2340
Ile Leu Leu Ile Glu Asp Ser Trp Gln Thr His Arg Ile His Asn 2345
2350 2355 Ala Leu Lys Gly Ile Pro Asp Asp Arg Asp Gly Leu Phe Asp
Thr 2360 2365 2370 Ile Gln Arg Ser Lys Asn His Tyr Gln Lys Arg Ala
Tyr Gln Cys 2375 2380 2385 Ile Lys Cys Met Val Ala Leu Phe Ser Ser
Cys Pro Val Ala Tyr 2390 2395 2400 Gln Ile Leu Gln Gly Asn Gly Asp
Leu Lys Arg Lys Trp Thr Trp 2405 2410 2415 Ala Val Glu Trp Leu Gly
Asp Glu Leu Glu Arg Arg Pro Tyr Thr 2420 2425 2430 Gly Asn Pro Gln
Tyr Ser Tyr Asn Asn Trp Ser Pro Pro Val Gln 2435 2440 2445 Ser Asn
Glu Thr Ala Asn Gly Tyr Phe Leu Glu Arg Ser His Ser 2450 2455 2460
Ala Arg Met Thr Leu Ala Lys Ala Cys Glu Leu Cys Pro Glu Glu 2465
2470 2475 Glu Pro Asp Asp Gln Asp Ala Pro Asp Glu His Glu Pro Ser
Pro 2480 2485 2490 Ser Glu Asp Ala Pro Leu Tyr Pro His Ser Pro Ala
Ser Gln Tyr 2495 2500 2505 Gln Gln Asn Asn His Val His Gly Gln Pro
Tyr Thr Gly Pro Ala 2510 2515 2520 Ala His His Leu Asn Asn Pro Gln
Lys Thr Gly Gln Arg Thr Gln 2525 2530 2535 Glu Asn Tyr Glu Gly Asn
Glu Glu Val Ser Ser Pro Gln Met Lys 2540 2545 2550 Asp Gln 2555
65330PRTHomo sapiens 65Met Ser Gln Trp His His Pro Arg Ser Gly Trp
Gly Arg Arg Arg Asp 1 5 10 15 Phe Ser Gly Arg Ser Ser Ala Lys Lys
Lys Gly Gly Asn His Ile Pro 20 25 30 Glu Arg Trp Lys Asp Tyr Leu
Pro Val Gly Gln Arg Met Pro Gly Thr 35 40 45 Arg Phe Ile Ala Phe
Lys Val Pro Leu Gln Lys Ser Phe Glu Lys Lys 50 55 60 Leu Ala Pro
Glu Glu Cys Phe Ser Pro Leu Asp Leu Phe Asn Lys Ile 65 70 75 80 Arg
Glu Gln Asn Glu Glu Leu Gly Leu Ile Ile Asp Leu Thr Tyr Thr 85 90
95 Gln Arg Tyr Tyr Lys Pro Glu Asp Leu Pro Glu Thr Val Pro Tyr Leu
100 105 110 Lys Ile Phe Thr Val Gly His Gln Val Pro Asp Asp Glu Thr
Ile Phe 115 120 125 Lys Phe Lys His Ala Val Asn Gly Phe Leu Lys Glu
Asn Lys Asp Asn 130 135 140 Asp Lys Leu Ile Gly Val His Cys Thr His
Gly Leu Asn Arg Thr Gly 145 150 155 160 Tyr Leu Ile Cys Arg Tyr Leu
Ile Asp Val Glu Gly Val Arg Pro Asp 165 170 175 Asp Ala Ile Glu Leu
Phe Asn Arg Cys Arg Gly His Cys Leu Glu Arg 180 185 190 Gln Asn Tyr
Ile Glu Asp Leu Gln Asn Gly Pro Ile Arg Lys Asn Trp 195 200 205 Asn
Ser Ser Val Pro Arg Ser Ser Asp Phe Glu Asp Ser Ala His Leu 210 215
220 Met Gln Pro Val His Asn Lys Pro Val Lys Gln Gly Pro Arg Tyr Asn
225 230 235 240 Leu His Gln Ile Gln Gly His Ser Ala Pro Arg His Phe
His Thr Gln 245 250 255 Thr Gln Ser Leu Gln Gln Ser Val Arg Lys Phe
Ser Glu Asn Pro His 260 265 270 Val Tyr Gln Arg His His Leu Pro Pro
Pro Gly Pro Pro Gly Glu Asp 275 280 285 Tyr Ser His Arg Arg Tyr Ser
Trp Asn Val Lys Pro Asn Ala Ser Arg 290 295 300 Ala Ala Gln Asp Arg
Arg Arg Trp Tyr Pro Tyr Asn Tyr Ser Arg Leu 305 310 315 320 Ser Tyr
Pro Ala Cys Trp Glu Trp Thr Gln 325 330 66185PRTHomo sapiens 66Met
Ser Gly Ser Phe Glu Leu Ser Val Gln Asp Leu Asn Asp Leu Leu 1 5 10
15 Ser Asp Gly Ser Gly Cys Tyr Ser Leu Pro Ser Gln Pro Cys Asn Glu
20 25 30 Val Thr Pro Arg Ile Tyr Val Gly Asn Ala Ser Val Ala Gln
Asp Ile 35 40 45 Pro Lys Leu Gln Lys Leu Gly Ile Thr His Val Leu
Asn Ala Ala Glu 50 55 60 Gly Arg Ser Phe Met His Val Asn Thr Asn
Ala Asn Phe Tyr Lys Asp 65 70 75 80 Ser Gly Ile Thr Tyr Leu Gly Ile
Lys Ala Asn Asp Thr Gln Glu Phe 85 90 95 Asn Leu Ser Ala Tyr Phe
Glu Arg Ala Ala Asp Phe Ile Asp Gln Ala 100 105 110 Leu Ala Gln Lys
Asn Gly Arg Val Leu Val His Cys Arg Glu Gly Tyr 115 120 125 Ser Arg
Ser Pro Thr Leu Val Ile Ala Tyr Leu Met Met Arg Gln Lys 130 135 140
Met Asp Val Lys Ser Ala Leu Ser Ile Val Arg Gln Asn Arg Glu Ile 145
150 155 160 Gly Pro Asn Asp Gly Phe Leu Ala Gln Leu Cys Gln Leu Asn
Asp Arg 165 170 175 Leu Ala Lys Glu Gly Lys Leu Lys Pro 180 185
671154PRTHomo sapiens 67Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn
Ala Met Ala Phe Cys 1 5 10 15 Ala Lys Met Arg Ser Ser Lys Lys Thr
Glu Val Asn Leu Glu Ala Pro 20 25 30 Glu Pro Gly Val Glu Val Ile
Phe Tyr Leu Ser Asp Arg Glu Pro Leu 35 40 45 Arg Leu Gly Ser Gly
Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 50 55 60 Ala Gln Ala
Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 65 70 75 80 Tyr
Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 85 90
95 Val Asp Asp
Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 100 105 110 Phe
Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 115 120
125 His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro
130 135 140 Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu
Phe Ala 145 150 155 160 Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala
Pro Ile Arg Asp Pro 165 170 175 Lys Thr Glu Gln Asp Gly His Asp Ile
Glu Asn Glu Cys Leu Gly Met 180 185 190 Ala Val Leu Ala Ile Ser His
Tyr Ala Met Met Lys Lys Met Gln Leu 195 200 205 Pro Glu Leu Pro Lys
Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 210 215 220 Leu Asn Lys
Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 225 230 235 240
Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 245
250 255 Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu
Ala 260 265 270 Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile
Phe Glu Thr 275 280 285 Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met
Asn Trp Phe His Ser 290 295 300 Asn Asp Gly Gly Asn Val Leu Tyr Tyr
Glu Val Met Val Thr Gly Asn 305 310 315 320 Leu Gly Ile Gln Trp Arg
His Lys Pro Asn Val Val Ser Val Glu Lys 325 330 335 Glu Lys Asn Lys
Leu Lys Arg Lys Lys Leu Glu Asn Lys Asp Lys Lys 340 345 350 Asp Glu
Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Phe 355 360 365
Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 370
375 380 Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His
Glu 385 390 395 400 Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr
Phe Arg Leu Thr 405 410 415 Ala Asp Ala His His Tyr Leu Cys Thr Asp
Val Ala Pro Pro Leu Ile 420 425 430 Val His Asn Ile Gln Asn Gly Cys
His Gly Pro Ile Cys Thr Glu Tyr 435 440 445 Ala Ile Asn Lys Leu Arg
Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 450 455 460 Leu Arg Trp Ser
Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 465 470 475 480 Cys
Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 485 490
495 Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser
500 505 510 Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu
Lys Lys 515 520 525 Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu
Lys Arg Cys Cys 530 535 540 Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu
Leu Val Ala Thr Lys Lys 545 550 555 560 Ala Gln Glu Trp Gln Pro Val
Tyr Pro Met Ser Gln Leu Ser Phe Asp 565 570 575 Arg Ile Leu Lys Lys
Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 580 585 590 Thr Arg Thr
His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 595 600 605 Glu
Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 610 615
620 Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser
625 630 635 640 Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu
Tyr Gly Val 645 650 655 Cys Val Arg Asp Val Glu Asn Ile Met Val Glu
Glu Phe Val Glu Gly 660 665 670 Gly Pro Leu Asp Leu Phe Met His Arg
Lys Ser Asp Val Leu Thr Thr 675 680 685 Pro Trp Lys Phe Lys Val Ala
Lys Gln Leu Ala Ser Ala Leu Ser Tyr 690 695 700 Leu Glu Asp Lys Asp
Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 705 710 715 720 Leu Leu
Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 725 730 735
Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 740
745 750 Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser
Lys 755 760 765 Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr
Thr Leu Trp 770 775 780 Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys
Asp Lys Thr Leu Ile 785 790 795 800 Glu Lys Glu Arg Phe Tyr Glu Ser
Arg Cys Arg Pro Val Thr Pro Ser 805 810 815 Cys Lys Glu Leu Ala Asp
Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 820 825 830 Asn Gln Arg Pro
Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 835 840 845 Glu Glu
Gln Asn Pro Asp Ile Val Ser Arg Lys Lys Asn Gln Pro Thr 850 855 860
Glu Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg 865
870 875 880 Asp Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg
Tyr Asp 885 890 895 Pro Glu Asp Asn Thr Gly Glu Gln Val Ala Val Lys
Ser Leu Lys Pro 900 905 910 Glu Ser Gly Gly Asn His Ile Ala Asp Leu
Lys Lys Glu Ile Glu Ile 915 920 925 Leu Arg Asn Leu Tyr His Glu Asn
Ile Val Lys Tyr Lys Gly Ile Cys 930 935 940 Thr Glu Asp Gly Gly Asn
Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 945 950 955 960 Ser Gly Ser
Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 965 970 975 Leu
Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 980 985
990 Tyr Leu Gly Ser Arg Gln Tyr Val His Arg Asp Leu Ala Ala Arg Asn
995 1000 1005 Val Leu Val Glu Ser Glu His Gln Val Lys Ile Gly Asp
Phe Gly 1010 1015 1020 Leu Thr Lys Ala Ile Glu Thr Asp Lys Glu Tyr
Tyr Thr Val Lys 1025 1030 1035 Asp Asp Arg Asp Ser Pro Val Phe Trp
Tyr Ala Pro Glu Cys Leu 1040 1045 1050 Met Gln Ser Lys Phe Tyr Ile
Ala Ser Asp Val Trp Ser Phe Gly 1055 1060 1065 Val Thr Leu His Glu
Leu Leu Thr Tyr Cys Asp Ser Asp Ser Ser 1070 1075 1080 Pro Met Ala
Leu Phe Leu Lys Met Ile Gly Pro Thr His Gly Gln 1085 1090 1095 Met
Thr Val Thr Arg Leu Val Asn Thr Leu Lys Glu Gly Lys Arg 1100 1105
1110 Leu Pro Cys Pro Pro Asn Cys Pro Asp Glu Val Tyr Gln Leu Met
1115 1120 1125 Arg Lys Cys Trp Glu Phe Gln Pro Ser Asn Arg Thr Ser
Phe Gln 1130 1135 1140 Asn Leu Ile Glu Gly Phe Glu Ala Leu Leu Lys
1145 1150 681141PRTHomo sapiens 68Met Ala Phe Cys Ala Lys Met Arg
Ser Ser Lys Lys Thr Glu Val Asn 1 5 10 15 Leu Glu Ala Pro Glu Pro
Gly Val Glu Val Ile Phe Tyr Leu Ser Asp 20 25 30 Arg Glu Pro Leu
Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu 35 40 45 Cys Ile
Arg Ala Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn 50 55 60
Leu Phe Ala Leu Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn 65
70 75 80 Arg Thr Ile Thr Val Asp Asp Lys Met Ser Leu Arg Leu His
Tyr Arg 85 90 95 Met Arg Phe Tyr Phe Thr Asn Trp His Gly Thr Asn
Asp Asn Glu Gln 100 105 110 Ser Val Trp Arg His Ser Pro Lys Lys Gln
Lys Asn Gly Tyr Glu Lys 115 120 125 Lys Lys Ile Pro Asp Ala Thr Pro
Leu Leu Asp Ala Ser Ser Leu Glu 130 135 140 Tyr Leu Phe Ala Gln Gly
Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro 145 150 155 160 Ile Arg Asp
Pro Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu 165 170 175 Cys
Leu Gly Met Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys 180 185
190 Lys Met Gln Leu Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr
195 200 205 Ile Pro Glu Thr Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu
Leu Thr 210 215 220 Arg Met Arg Ile Asn Asn Val Phe Lys Asp Phe Leu
Lys Glu Phe Asn 225 230 235 240 Asn Lys Thr Ile Cys Asp Ser Ser Val
Ser Thr His Asp Leu Lys Val 245 250 255 Lys Tyr Leu Ala Thr Leu Glu
Thr Leu Thr Lys His Tyr Gly Ala Glu 260 265 270 Ile Phe Glu Thr Ser
Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn 275 280 285 Trp Phe His
Ser Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met 290 295 300 Val
Thr Gly Asn Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val 305 310
315 320 Ser Val Glu Lys Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu
Asn 325 330 335 Lys Asp Lys Lys Asp Glu Glu Lys Asn Lys Ile Arg Glu
Glu Trp Asn 340 345 350 Asn Phe Ser Phe Phe Pro Glu Ile Thr His Ile
Val Ile Lys Glu Ser 355 360 365 Val Val Ser Ile Asn Lys Gln Asp Asn
Lys Lys Met Glu Leu Lys Leu 370 375 380 Ser Ser His Glu Glu Ala Leu
Ser Phe Val Ser Leu Val Asp Gly Tyr 385 390 395 400 Phe Arg Leu Thr
Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala 405 410 415 Pro Pro
Leu Ile Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile 420 425 430
Cys Thr Glu Tyr Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu 435
440 445 Gly Met Tyr Val Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile
Leu 450 455 460 Met Thr Val Thr Cys Phe Glu Lys Ser Glu Gln Val Gln
Gly Ala Gln 465 470 475 480 Lys Gln Phe Lys Asn Phe Gln Ile Glu Val
Gln Lys Gly Arg Tyr Ser 485 490 495 Leu His Gly Ser Asp Arg Ser Phe
Pro Ser Leu Gly Asp Leu Met Ser 500 505 510 His Leu Lys Lys Gln Ile
Leu Arg Thr Asp Asn Ile Ser Phe Met Leu 515 520 525 Lys Arg Cys Cys
Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val 530 535 540 Ala Thr
Lys Lys Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln 545 550 555
560 Leu Ser Phe Asp Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His
565 570 575 Leu Gly Arg Gly Thr Arg Thr His Ile Tyr Ser Gly Thr Leu
Met Asp 580 585 590 Tyr Lys Asp Asp Glu Gly Thr Ser Glu Glu Lys Lys
Ile Lys Val Ile 595 600 605 Leu Lys Val Leu Asp Pro Ser His Arg Asp
Ile Ser Leu Ala Phe Phe 610 615 620 Glu Ala Ala Ser Met Met Arg Gln
Val Ser His Lys His Ile Val Tyr 625 630 635 640 Leu Tyr Gly Val Cys
Val Arg Asp Val Glu Asn Ile Met Val Glu Glu 645 650 655 Phe Val Glu
Gly Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp 660 665 670 Val
Leu Thr Thr Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser 675 680
685 Ala Leu Ser Tyr Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys
690 695 700 Thr Lys Asn Leu Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu
Cys Gly 705 710 715 720 Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Pro
Ile Thr Val Leu Ser 725 730 735 Arg Gln Glu Cys Ile Glu Arg Ile Pro
Trp Ile Ala Pro Glu Cys Val 740 745 750 Glu Asp Ser Lys Asn Leu Ser
Val Ala Ala Asp Lys Trp Ser Phe Gly 755 760 765 Thr Thr Leu Trp Glu
Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp 770 775 780 Lys Thr Leu
Ile Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro 785 790 795 800
Val Thr Pro Ser Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met 805
810 815 Asn Tyr Asp Pro Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg
Asp 820 825 830 Ile Asn Lys Leu Glu Glu Gln Asn Pro Asp Ile Val Ser
Arg Lys Lys 835 840 845 Asn Gln Pro Thr Glu Val Asp Pro Thr His Phe
Glu Lys Arg Phe Leu 850 855 860 Lys Arg Ile Arg Asp Leu Gly Glu Gly
His Phe Gly Lys Val Glu Leu 865 870 875 880 Cys Arg Tyr Asp Pro Glu
Asp Asn Thr Gly Glu Gln Val Ala Val Lys 885 890 895 Ser Leu Lys Pro
Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys 900 905 910 Glu Ile
Glu Ile Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr 915 920 925
Lys Gly Ile Cys Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met 930
935 940 Glu Phe Leu Pro Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn
Lys 945 950 955 960 Asn Lys Ile Asn Leu Lys Gln Gln Leu Lys Tyr Ala
Val Gln Ile Cys 965 970 975 Lys Gly Met Asp Tyr Leu Gly Ser Arg Gln
Tyr Val His Arg Asp Leu 980 985 990 Ala Ala Arg Asn Val Leu Val Glu
Ser Glu His Gln Val Lys Ile Asp 995 1000 1005 Phe Gly Leu Thr Lys
Ala Ile Glu Thr Asp Lys Glu Tyr Tyr Thr 1010 1015 1020 Val Lys Asp
Asp Arg Asp Ser Pro Val Phe Trp Tyr Ala Pro Glu 1025 1030 1035 Cys
Leu Met Gln Ser Lys Phe Tyr Ile Ala Ser Asp Val Trp Ser 1040 1045
1050 Phe Gly Val Thr Leu His Glu Leu Leu Thr Tyr Cys Asp Ser Asp
1055 1060 1065 Ser Ser Pro Met Ala Leu Phe Leu Lys Met Ile Gly Pro
Thr His 1070 1075 1080 Gly Gln Met Thr Val Thr Arg Leu Val Asn Thr
Leu Lys Glu Gly 1085 1090 1095 Lys Arg Leu Pro Cys Pro Pro Asn Cys
Pro Asp Glu Val Tyr Gln 1100 1105 1110 Leu Met Arg Lys Cys Trp Glu
Phe Gln Pro Ser Asn Arg Thr Ser 1115 1120 1125 Phe Gln Asn Leu Ile
Glu Gly Phe Glu Ala Leu Leu Lys 1130 1135 1140 69666PRTHomo sapiens
69Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 1
5 10 15 Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val
Ser 20 25 30 Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu
Thr Asp Leu 35 40 45 Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn
Leu Thr Glu Ala Gln 50 55 60 Arg Phe Ser Ser Leu Pro Arg Arg Ala
Ala Val Asn Ile Glu Phe Arg 65 70 75 80 Asp Leu Ser Tyr Ser Val Pro
Glu Gly Pro Trp
Trp Arg Lys Lys Gly 85 90 95 Tyr Lys Thr Leu Leu Lys Gly Ile Ser
Gly Lys Phe Asn Ser Gly Glu 100 105 110 Leu Val Ala Ile Met Gly Pro
Ser Gly Ala Gly Lys Ser Thr Leu Met 115 120 125 Asn Ile Leu Ala Gly
Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 130 135 140 Ile Asn Gly
Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 145 150 155 160
Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 165
170 175 Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu
Gly 180 185 190 Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly
Leu Leu Ser 195 200 205 Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly
Gly Gln Arg Lys Arg 210 215 220 Leu Ala Ile Ala Leu Glu Leu Val Asn
Asn Pro Pro Val Met Phe Phe 225 230 235 240 Asp Glu Pro Thr Ser Gly
Leu Asp Ser Ala Ser Cys Phe Gln Val Val 245 250 255 Ser Leu Met Lys
Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 260 265 270 Ile His
Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 275 280 285
Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 290
295 300 Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His
Asn 305 310 315 320 Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu
Tyr Gly Asp Gln 325 330 335 Asn Ser Arg Leu Val Arg Ala Val Arg Glu
Gly Met Cys Asp Ser Asp 340 345 350 His Lys Arg Asp Leu Gly Gly Asp
Ala Glu Val Asn Pro Phe Leu Trp 355 360 365 His Arg Pro Ser Glu Glu
Asp Ser Ser Ser Met Glu Gly Cys His Ser 370 375 380 Phe Ser Ala Ser
Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr 385 390 395 400 Phe
Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr 405 410
415 Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile
420 425 430 Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu
Phe Phe 435 440 445 Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro
Thr Val Leu Thr 450 455 460 Phe Pro Leu Glu Met Gly Val Phe Leu Arg
Glu His Leu Asn Tyr Trp 465 470 475 480 Tyr Ser Leu Lys Ala Tyr Tyr
Leu Ala Lys Thr Met Ala Asp Val Pro 485 490 495 Phe Gln Ile Met Phe
Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met 500 505 510 Thr Ser Gln
Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu 515 520 525 Gly
Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly 530 535
540 Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr
545 550 555 560 Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser
Phe Asp Thr 565 570 575 Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile
Ser Tyr Val Arg Tyr 580 585 590 Gly Phe Glu Gly Val Ile Leu Ser Ile
Tyr Gly Leu Asp Arg Glu Asp 595 600 605 Leu His Cys Asp Ile Asp Glu
Thr Cys His Phe Gln Lys Ser Glu Ala 610 615 620 Ile Leu Arg Glu Leu
Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe 625 630 635 640 Ile Val
Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe 645 650 655
Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg 660 665 70678PRTHomo
sapiens 70Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met
Asn Ala 1 5 10 15 Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser
Val Cys Val Ser 20 25 30 Val Asp Glu Val Val Ser Ser Asn Met Glu
Ala Thr Glu Thr Asp Leu 35 40 45 Leu Asn Gly His Leu Lys Lys Val
Asp Asn Asn Leu Thr Glu Ala Gln 50 55 60 Arg Phe Ser Ser Leu Pro
Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 65 70 75 80 Asp Leu Ser Tyr
Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 85 90 95 Tyr Lys
Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 100 105 110
Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 115
120 125 Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val
Leu 130 135 140 Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys
Val Ser Cys 145 150 155 160 Tyr Ile Met Gln Asp Asp Met Leu Leu Pro
His Leu Thr Val Gln Glu 165 170 175 Ala Met Met Val Ser Ala His Leu
Lys Leu Gln Glu Lys Asp Glu Gly 180 185 190 Arg Arg Glu Met Val Lys
Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 195 200 205 Cys Ala Asn Thr
Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 210 215 220 Leu Ala
Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 225 230 235
240 Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val
245 250 255 Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile
Cys Thr 260 265 270 Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe
Asp Gln Leu Tyr 275 280 285 Val Leu Ser Gln Gly Gln Cys Val Tyr Arg
Gly Lys Val Cys Asn Leu 290 295 300 Val Pro Tyr Leu Arg Asp Leu Gly
Leu Asn Cys Pro Thr Tyr His Asn 305 310 315 320 Pro Ala Asp Phe Val
Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 325 330 335 Asn Ser Arg
Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 340 345 350 His
Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 355 360
365 His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu
370 375 380 Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser
Ala Ser 385 390 395 400 Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg
Thr Phe Leu Ser Ile 405 410 415 Met Arg Asp Ser Val Leu Thr His Leu
Arg Ile Thr Ser His Ile Gly 420 425 430 Ile Gly Leu Leu Ile Gly Leu
Leu Tyr Leu Gly Ile Gly Asn Glu Ala 435 440 445 Lys Lys Val Leu Ser
Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe 450 455 460 Leu Met Phe
Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu 465 470 475 480
Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys 485
490 495 Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile
Met 500 505 510 Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr
Ser Gln Pro 515 520 525 Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala
Leu Gly Thr Met Thr 530 535 540 Ser Leu Val Ala Gln Ser Leu Gly Leu
Leu Ile Gly Ala Ala Ser Thr 545 550 555 560 Ser Leu Gln Val Ala Thr
Phe Val Gly Pro Val Thr Ala Ile Pro Val 565 570 575 Leu Leu Phe Ser
Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr 580 585 590 Leu Gln
Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly 595 600 605
Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp 610
615 620 Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg
Glu 625 630 635 640 Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe
Ile Val Leu Gly 645 650 655 Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala
Tyr Phe Val Leu Arg Tyr 660 665 670 Lys Ile Arg Ala Glu Arg 675
71677PRTHomo sapiens 71Met Arg Ile Ser Leu Pro Arg Ala Pro Glu Arg
Asp Gly Gly Val Ser 1 5 10 15 Ala Ser Ser Leu Leu Asp Thr Val Thr
Asn Ala Ser Ser Tyr Ser Ala 20 25 30 Glu Met Thr Glu Pro Lys Ser
Val Cys Val Ser Val Asp Glu Val Val 35 40 45 Ser Ser Asn Met Glu
Ala Thr Glu Thr Asp Leu Leu Asn Gly His Leu 50 55 60 Lys Lys Val
Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser Ser Leu 65 70 75 80 Pro
Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser Tyr Ser 85 90
95 Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr Leu Leu
100 105 110 Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala
Ile Met 115 120 125 Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn
Ile Leu Ala Gly 130 135 140 Tyr Arg Glu Thr Gly Met Lys Gly Ala Val
Leu Ile Asn Gly Leu Pro 145 150 155 160 Arg Asp Leu Arg Cys Phe Arg
Lys Val Ser Cys Tyr Ile Met Gln Asp 165 170 175 Asp Met Leu Leu Pro
His Leu Thr Val Gln Glu Ala Met Met Val Ser 180 185 190 Ala His Leu
Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu Met Val 195 200 205 Lys
Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn Thr Arg 210 215
220 Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile Ala Leu
225 230 235 240 Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu
Pro Thr Ser 245 250 255 Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val
Ser Leu Met Lys Gly 260 265 270 Leu Ala Gln Gly Gly Arg Ser Ile Ile
Cys Thr Ile His Gln Pro Ser 275 280 285 Ala Lys Leu Phe Glu Leu Phe
Asp Gln Leu Tyr Val Leu Ser Gln Gly 290 295 300 Gln Cys Val Tyr Arg
Gly Lys Val Cys Asn Leu Val Pro Tyr Leu Arg 305 310 315 320 Asp Leu
Gly Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp Phe Val 325 330 335
Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg Leu Val 340
345 350 Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg Asp
Leu 355 360 365 Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg
Pro Ser Glu 370 375 380 Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser
Phe Ser Ala Ser Cys 385 390 395 400 Leu Thr Gln Phe Cys Ile Leu Phe
Lys Arg Thr Phe Leu Ser Ile Met 405 410 415 Arg Asp Ser Val Leu Thr
His Leu Arg Ile Thr Ser His Ile Gly Ile 420 425 430 Gly Leu Leu Ile
Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala Lys 435 440 445 Lys Val
Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe Leu 450 455 460
Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu Met 465
470 475 480 Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu
Lys Ala 485 490 495 Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe
Gln Ile Met Phe 500 505 510 Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp
Met Thr Ser Gln Pro Ser 515 520 525 Asp Ala Val Arg Phe Val Leu Phe
Ala Ala Leu Gly Thr Met Thr Ser 530 535 540 Leu Val Ala Gln Ser Leu
Gly Leu Leu Ile Gly Ala Ala Ser Thr Ser 545 550 555 560 Leu Gln Val
Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val Leu 565 570 575 Leu
Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr Leu 580 585
590 Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly Val
595 600 605 Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys
Asp Ile 610 615 620 Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile
Leu Arg Glu Leu 625 630 635 640 Asp Val Glu Asn Ala Lys Leu Tyr Leu
Asp Phe Ile Val Leu Gly Ile 645 650 655 Phe Phe Ile Ser Leu Arg Leu
Ile Ala Tyr Phe Val Leu Arg Tyr Lys 660 665 670 Ile Arg Ala Glu Arg
675 72668PRTHomo sapiens 72Met Leu Gly Thr Gln Gly Trp Thr Lys Gln
Arg Lys Pro Cys Pro Gln 1 5 10 15 Asn Ala Ser Ser Tyr Ser Ala Glu
Met Thr Glu Pro Lys Ser Val Cys 20 25 30 Val Ser Val Asp Glu Val
Val Ser Ser Asn Met Glu Ala Thr Glu Thr 35 40 45 Asp Leu Leu Asn
Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu 50 55 60 Ala Gln
Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu 65 70 75 80
Phe Arg Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys 85
90 95 Lys Gly Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn
Ser 100 105 110 Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly
Lys Ser Thr 115 120 125 Leu Met Asn Ile Leu Ala Gly Tyr Arg Glu Thr
Gly Met Lys Gly Ala 130 135 140 Val Leu Ile Asn Gly Leu Pro Arg Asp
Leu Arg Cys Phe Arg Lys Val 145 150 155 160 Ser Cys Tyr Ile Met Gln
Asp Asp Met Leu Leu Pro His Leu Thr Val 165 170 175 Gln Glu Ala Met
Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp 180 185 190 Glu Gly
Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu 195 200 205
Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg 210
215 220 Lys Arg Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val
Met 225 230 235 240 Phe Phe Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala
Ser Cys Phe Gln 245 250 255 Val Val Ser Leu Met Lys Gly Leu Ala Gln
Gly Gly Arg Ser Ile Ile 260 265 270 Cys Thr Ile His Gln Pro Ser Ala
Lys Leu Phe Glu Leu Phe Asp Gln 275 280 285 Leu Tyr Val Leu Ser Gln
Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 290 295 300 Asn Leu Val Pro
Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr 305 310 315 320 His
Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly 325 330
335 Asp Gln Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp
340 345 350 Ser Asp His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn
Pro Phe 355
360 365 Leu Trp His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly
Cys 370 375 380 His Ser Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile
Leu Phe Lys 385 390 395 400 Arg Thr Phe Leu Ser Ile Met Arg Asp Ser
Val Leu Thr His Leu Arg 405 410 415 Ile Thr Ser His Ile Gly Ile Gly
Leu Leu Ile Gly Leu Leu Tyr Leu 420 425 430 Gly Ile Gly Asn Glu Ala
Lys Lys Val Leu Ser Asn Ser Gly Phe Leu 435 440 445 Phe Phe Ser Met
Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val 450 455 460 Leu Thr
Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn 465 470 475
480 Tyr Trp Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp
485 490 495 Val Pro Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile
Val Tyr 500 505 510 Trp Met Thr Ser Gln Pro Ser Asp Ala Val Arg Phe
Val Leu Phe Ala 515 520 525 Ala Leu Gly Thr Met Thr Ser Leu Val Ala
Gln Ser Leu Gly Leu Leu 530 535 540 Ile Gly Ala Ala Ser Thr Ser Leu
Gln Val Ala Thr Phe Val Gly Pro 545 550 555 560 Val Thr Ala Ile Pro
Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe 565 570 575 Asp Thr Ile
Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val 580 585 590 Arg
Tyr Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg 595 600
605 Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser
610 615 620 Glu Ala Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu
Tyr Leu 625 630 635 640 Asp Phe Ile Val Leu Gly Ile Phe Phe Ile Ser
Leu Arg Leu Ile Ala 645 650 655 Tyr Phe Val Leu Arg Tyr Lys Ile Arg
Ala Glu Arg 660 665 73644PRTHomo sapiens 73Met Thr Glu Pro Lys Ser
Val Cys Val Ser Val Asp Glu Val Val Ser 1 5 10 15 Ser Asn Met Glu
Ala Thr Glu Thr Asp Leu Leu Asn Gly His Leu Lys 20 25 30 Lys Val
Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser Ser Leu Pro 35 40 45
Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser Tyr Ser Val 50
55 60 Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr Leu Leu
Lys 65 70 75 80 Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala
Ile Met Gly 85 90 95 Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn
Ile Leu Ala Gly Tyr 100 105 110 Arg Glu Thr Gly Met Lys Gly Ala Val
Leu Ile Asn Gly Leu Pro Arg 115 120 125 Asp Leu Arg Cys Phe Arg Lys
Val Ser Cys Tyr Ile Met Gln Asp Asp 130 135 140 Met Leu Leu Pro His
Leu Thr Val Gln Glu Ala Met Met Val Ser Ala 145 150 155 160 His Leu
Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu Met Val Lys 165 170 175
Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn Thr Arg Thr 180
185 190 Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile Ala Leu
Glu 195 200 205 Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu Pro
Thr Ser Gly 210 215 220 Leu Asp Ser Ala Ser Cys Phe Gln Val Val Ser
Leu Met Lys Gly Leu 225 230 235 240 Ala Gln Gly Gly Arg Ser Ile Ile
Cys Thr Ile His Gln Pro Ser Ala 245 250 255 Lys Leu Phe Glu Leu Phe
Asp Gln Leu Tyr Val Leu Ser Gln Gly Gln 260 265 270 Cys Val Tyr Arg
Gly Lys Val Cys Asn Leu Val Pro Tyr Leu Arg Asp 275 280 285 Leu Gly
Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp Phe Val Met 290 295 300
Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg Leu Val Arg 305
310 315 320 Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg Asp
Leu Gly 325 330 335 Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg
Pro Ser Glu Glu 340 345 350 Asp Ser Ser Ser Met Glu Gly Cys His Ser
Phe Ser Ala Ser Cys Leu 355 360 365 Thr Gln Phe Cys Ile Leu Phe Lys
Arg Thr Phe Leu Ser Ile Met Arg 370 375 380 Asp Ser Val Leu Thr His
Leu Arg Ile Thr Ser His Ile Gly Ile Gly 385 390 395 400 Leu Leu Ile
Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala Lys Lys 405 410 415 Val
Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe Leu Met 420 425
430 Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu Met Gly
435 440 445 Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys
Ala Tyr 450 455 460 Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln
Ile Met Phe Pro 465 470 475 480 Val Ala Tyr Cys Ser Ile Val Tyr Trp
Met Thr Ser Gln Pro Ser Asp 485 490 495 Ala Val Arg Phe Val Leu Phe
Ala Ala Leu Gly Thr Met Thr Ser Leu 500 505 510 Val Ala Gln Ser Leu
Gly Leu Leu Ile Gly Ala Ala Ser Thr Ser Leu 515 520 525 Gln Val Ala
Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val Leu Leu 530 535 540 Phe
Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr Leu Gln 545 550
555 560 Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly Val
Ile 565 570 575 Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys
Asp Ile Asp 580 585 590 Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile
Leu Arg Glu Leu Asp 595 600 605 Val Glu Asn Ala Lys Leu Tyr Leu Asp
Phe Ile Val Leu Gly Ile Phe 610 615 620 Phe Ile Ser Leu Arg Leu Ile
Ala Tyr Phe Val Leu Arg Tyr Lys Ile 625 630 635 640 Arg Ala Glu Arg
74663PRTHomo sapiens 74Met Ile Met Arg Leu Pro Gln Pro His Gly Thr
Asn Ala Ser Ser Tyr 1 5 10 15 Ser Ala Glu Met Thr Glu Pro Lys Ser
Val Cys Val Ser Val Asp Glu 20 25 30 Val Val Ser Ser Asn Met Glu
Ala Thr Glu Thr Asp Leu Leu Asn Gly 35 40 45 His Leu Lys Lys Val
Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser 50 55 60 Ser Leu Pro
Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser 65 70 75 80 Tyr
Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr 85 90
95 Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala
100 105 110 Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn
Ile Leu 115 120 125 Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val
Leu Ile Asn Gly 130 135 140 Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys
Val Ser Cys Tyr Ile Met 145 150 155 160 Gln Asp Asp Met Leu Leu Pro
His Leu Thr Val Gln Glu Ala Met Met 165 170 175 Val Ser Ala His Leu
Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu 180 185 190 Met Val Lys
Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn 195 200 205 Thr
Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile 210 215
220 Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu Pro
225 230 235 240 Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val
Ser Leu Met 245 250 255 Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile
Cys Thr Ile His Gln 260 265 270 Pro Ser Ala Lys Leu Phe Glu Leu Phe
Asp Gln Leu Tyr Val Leu Ser 275 280 285 Gln Gly Gln Cys Val Tyr Arg
Gly Lys Val Cys Asn Leu Val Pro Tyr 290 295 300 Leu Arg Asp Leu Gly
Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp 305 310 315 320 Phe Val
Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg 325 330 335
Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg 340
345 350 Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg
Pro 355 360 365 Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser
Phe Ser Ala 370 375 380 Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys
Arg Thr Phe Leu Ser 385 390 395 400 Ile Met Arg Asp Ser Val Leu Thr
His Leu Arg Ile Thr Ser His Ile 405 410 415 Gly Ile Gly Leu Leu Ile
Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu 420 425 430 Ala Lys Lys Val
Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu 435 440 445 Phe Leu
Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu 450 455 460
Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 465
470 475 480 Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe
Gln Ile 485 490 495 Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp
Met Thr Ser Gln 500 505 510 Pro Ser Asp Ala Val Arg Phe Val Leu Phe
Ala Ala Leu Gly Thr Met 515 520 525 Thr Ser Leu Val Ala Gln Ser Leu
Gly Leu Leu Ile Gly Ala Ala Ser 530 535 540 Thr Ser Leu Gln Val Ala
Thr Phe Val Gly Pro Val Thr Ala Ile Pro 545 550 555 560 Val Leu Leu
Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr 565 570 575 Tyr
Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu 580 585
590 Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys
595 600 605 Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile
Leu Arg 610 615 620 Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp
Phe Ile Val Leu 625 630 635 640 Gly Ile Phe Phe Ile Ser Leu Arg Leu
Ile Ala Tyr Phe Val Leu Arg 645 650 655 Tyr Lys Ile Arg Ala Glu Arg
660 75824PRTHomo sapiens 75Met Leu Ala Val Gln Gln Thr Glu His Leu
Pro Ala Cys Pro Pro Ala 1 5 10 15 Arg Arg Trp Ser Ser Asn Phe Cys
Pro Glu Ser Thr Glu Gly Gly Pro 20 25 30 Ser Leu Leu Gly Leu Arg
Asp Met Val Arg Arg Gly Trp Ser Val Cys 35 40 45 Thr Ala Ile Leu
Leu Ala Arg Leu Trp Cys Leu Val Pro Thr His Thr 50 55 60 Phe Leu
Ser Glu Tyr Pro Glu Ala Ala Glu Tyr Pro His Pro Gly Trp 65 70 75 80
Val Tyr Trp Leu Gln Met Ala Val Ala Pro Gly His Leu Arg Ala Trp 85
90 95 Val Met Arg Asn Asn Val Thr Thr Asn Ile Pro Ser Ala Phe Ser
Gly 100 105 110 Thr Leu Thr His Glu Glu Lys Ala Val Leu Thr Val Phe
Thr Gly Thr 115 120 125 Ala Thr Ala Val His Val Gln Val Ala Ala Leu
Ala Ser Ala Lys Leu 130 135 140 Glu Ser Ser Val Phe Val Thr Asp Cys
Val Ser Cys Lys Ile Glu Asn 145 150 155 160 Val Cys Asp Ser Ala Leu
Gln Gly Lys Arg Val Pro Met Ser Gly Leu 165 170 175 Gln Gly Ser Ser
Ile Val Ile Met Pro Pro Ser Asn Arg Pro Leu Ala 180 185 190 Ser Ala
Ala Ser Cys Thr Trp Ser Val Gln Val Gln Gly Gly Pro His 195 200 205
His Leu Gly Val Val Ala Ile Ser Gly Lys Val Leu Ser Ala Ala His 210
215 220 Gly Ala Gly Arg Ala Tyr Gly Trp Gly Phe Pro Gly Asp Pro Met
Glu 225 230 235 240 Glu Gly Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly
Lys Phe Asn Ser 245 250 255 Gly Glu Leu Val Ala Ile Met Gly Pro Ser
Gly Ala Gly Lys Ser Thr 260 265 270 Leu Met Asn Ile Leu Ala Gly Tyr
Arg Glu Thr Gly Met Lys Gly Ala 275 280 285 Val Leu Ile Asn Gly Leu
Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 290 295 300 Ser Cys Tyr Ile
Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 305 310 315 320 Gln
Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp 325 330
335 Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu
340 345 350 Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly
Gln Arg 355 360 365 Lys Arg Leu Ala Ile Ala Leu Glu Leu Val Asn Asn
Pro Pro Val Met 370 375 380 Phe Phe Asp Glu Pro Thr Ser Gly Leu Asp
Ser Ala Ser Cys Phe Gln 385 390 395 400 Val Val Ser Leu Met Lys Gly
Leu Ala Gln Gly Gly Arg Ser Ile Ile 405 410 415 Cys Thr Ile His Gln
Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 420 425 430 Leu Tyr Val
Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 435 440 445 Asn
Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr 450 455
460 His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly
465 470 475 480 Asp Gln Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly
Met Cys Asp 485 490 495 Ser Asp His Lys Arg Asp Leu Gly Gly Asp Ala
Glu Val Asn Pro Phe 500 505 510 Leu Trp His Arg Pro Ser Glu Glu Val
Lys Gln Thr Lys Arg Leu Lys 515 520 525 Gly Leu Arg Lys Asp Ser Ser
Ser Met Glu Gly Cys His Ser Phe Ser 530 535 540 Ala Ser Cys Leu Thr
Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu 545 550 555 560 Ser Ile
Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His 565 570 575
Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn 580
585 590 Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser
Met 595 600 605 Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu
Thr Phe Pro 610 615 620 Leu Glu Met Gly Val Phe Leu Arg Glu His Leu
Asn Tyr Trp Tyr Ser 625 630 635 640 Leu Lys Ala Tyr Tyr Leu Ala Lys
Thr Met Ala Asp Val Pro Phe Gln 645 650 655 Ile Met Phe Pro Val Ala
Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser 660 665 670 Gln Pro Ser Asp
Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr 675 680 685
Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala 690
695 700 Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala
Ile 705 710 715 720 Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe
Asp Thr Ile Pro 725 730 735 Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser
Tyr Val Arg Tyr Gly Phe 740 745 750 Glu Gly Val Ile Leu Ser Ile Tyr
Gly Leu Asp Arg Glu Asp Leu His 755 760 765 Cys Asp Ile Asp Glu Thr
Cys His Phe Gln Lys Ser Glu Ala Ile Leu 770 775 780 Arg Glu Leu Asp
Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val 785 790 795 800 Leu
Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu 805 810
815 Arg Tyr Lys Ile Arg Ala Glu Arg 820 76970PRTHomo sapiens 76Met
Ala Gln Leu Glu Arg Ser Ala Ile Ser Gly Phe Ser Ser Lys Ser 1 5 10
15 Arg Arg Asn Ser Phe Ala Tyr Asp Val Lys Arg Glu Val Tyr Asn Glu
20 25 30 Glu Thr Phe Gln Gln Glu His Lys Arg Lys Ala Ser Ser Ser
Gly Asn 35 40 45 Met Asn Ile Asn Ile Thr Thr Phe Arg His His Val
Gln Cys Arg Cys 50 55 60 Ser Trp His Arg Phe Leu Arg Cys Val Leu
Thr Ile Phe Pro Phe Leu 65 70 75 80 Glu Trp Met Cys Met Tyr Arg Leu
Lys Asp Trp Leu Leu Gly Asp Leu 85 90 95 Leu Ala Gly Ile Ser Val
Gly Leu Val Gln Val Pro Gln Gly Leu Thr 100 105 110 Leu Ser Leu Leu
Ala Arg Gln Leu Ile Pro Pro Leu Asn Ile Ala Tyr 115 120 125 Ala Ala
Phe Cys Ser Ser Val Ile Tyr Val Ile Phe Gly Ser Cys His 130 135 140
Gln Met Ser Ile Gly Ser Phe Phe Leu Val Ser Ala Leu Leu Ile Asn 145
150 155 160 Val Leu Lys Val Ser Pro Phe Asn Asn Gly Gln Leu Val Met
Gly Ser 165 170 175 Phe Val Lys Asn Glu Phe Ser Ala Pro Ser Tyr Leu
Met Gly Tyr Asn 180 185 190 Lys Ser Leu Ser Val Val Ala Thr Thr Thr
Phe Leu Thr Gly Ile Ile 195 200 205 Gln Leu Ile Met Gly Val Leu Gly
Leu Gly Phe Ile Ala Thr Tyr Leu 210 215 220 Pro Glu Ser Ala Met Ser
Ala Tyr Leu Ala Ala Val Ala Leu His Ile 225 230 235 240 Met Leu Ser
Gln Leu Thr Phe Ile Phe Gly Ile Met Ile Ser Phe His 245 250 255 Ala
Gly Pro Ile Ser Phe Phe Tyr Asp Ile Ile Asn Tyr Cys Val Ala 260 265
270 Leu Pro Lys Ala Asn Ser Thr Ser Ile Leu Val Phe Leu Thr Val Val
275 280 285 Val Ala Leu Arg Ile Asn Lys Cys Ile Arg Ile Ser Phe Asn
Gln Tyr 290 295 300 Pro Ile Glu Phe Pro Met Glu Leu Phe Leu Ile Ile
Gly Phe Thr Val 305 310 315 320 Ile Ala Asn Lys Ile Ser Met Ala Thr
Glu Thr Ser Gln Thr Leu Ile 325 330 335 Asp Met Ile Pro Tyr Ser Phe
Leu Leu Pro Val Thr Pro Asp Phe Ser 340 345 350 Leu Leu Pro Lys Ile
Ile Leu Gln Ala Phe Ser Leu Ser Leu Val Ser 355 360 365 Ser Phe Leu
Leu Ile Phe Leu Gly Lys Lys Ile Ala Ser Leu His Asn 370 375 380 Tyr
Ser Val Asn Ser Asn Gln Asp Leu Ile Ala Ile Gly Leu Cys Asn 385 390
395 400 Val Val Ser Ser Phe Phe Arg Ser Cys Val Phe Thr Gly Ala Ile
Ala 405 410 415 Arg Thr Ile Ile Gln Asp Lys Ser Gly Gly Arg Gln Gln
Phe Ala Ser 420 425 430 Leu Val Gly Ala Gly Val Met Leu Leu Leu Met
Val Lys Met Gly His 435 440 445 Phe Phe Tyr Thr Leu Pro Asn Ala Val
Leu Ala Gly Ile Ile Leu Ser 450 455 460 Asn Val Ile Pro Tyr Leu Glu
Thr Ile Ser Asn Leu Pro Ser Leu Trp 465 470 475 480 Arg Gln Asp Gln
Tyr Asp Cys Ala Leu Trp Met Met Thr Phe Ser Ser 485 490 495 Ser Ile
Phe Leu Gly Leu Asp Ile Gly Leu Ile Ile Ser Val Val Ser 500 505 510
Ala Phe Phe Ile Thr Thr Val Arg Ser His Arg Ala Lys Ile Leu Leu 515
520 525 Leu Gly Gln Ile Pro Asn Thr Asn Ile Tyr Arg Ser Ile Asn Asp
Tyr 530 535 540 Arg Glu Ile Ile Thr Ile Pro Gly Val Lys Ile Phe Gln
Cys Cys Ser 545 550 555 560 Ser Ile Thr Phe Val Asn Val Tyr Tyr Leu
Lys His Lys Leu Leu Lys 565 570 575 Glu Val Asp Met Val Lys Val Pro
Leu Lys Glu Glu Glu Ile Phe Ser 580 585 590 Leu Phe Asn Ser Ser Asp
Thr Asn Leu Gln Gly Gly Lys Ile Cys Arg 595 600 605 Cys Phe Cys Asn
Cys Asp Asp Leu Glu Pro Leu Pro Arg Ile Leu Tyr 610 615 620 Thr Glu
Arg Phe Glu Asn Lys Leu Asp Pro Glu Ala Ser Ser Ile Asn 625 630 635
640 Leu Ile His Cys Ser His Phe Glu Ser Met Asn Thr Ser Gln Thr Ala
645 650 655 Ser Glu Asp Gln Val Pro Tyr Thr Val Ser Ser Val Ser Gln
Lys Asn 660 665 670 Gln Gly Gln Gln Tyr Glu Glu Val Glu Glu Val Trp
Leu Pro Asn Asn 675 680 685 Ser Ser Arg Asn Ser Ser Pro Gly Leu Pro
Asp Val Ala Glu Ser Gln 690 695 700 Gly Arg Arg Ser Leu Ile Pro Tyr
Ser Asp Ala Ser Leu Leu Pro Ser 705 710 715 720 Val His Thr Ile Ile
Leu Asp Phe Ser Met Val His Tyr Val Asp Ser 725 730 735 Arg Gly Leu
Val Val Leu Arg Gln Ile Cys Asn Ala Phe Gln Asn Ala 740 745 750 Asn
Ile Leu Ile Leu Ile Ala Gly Cys His Ser Ser Ile Val Arg Ala 755 760
765 Phe Glu Arg Asn Asp Phe Phe Asp Ala Gly Ile Thr Lys Thr Gln Leu
770 775 780 Phe Leu Ser Val His Asp Ala Val Leu Phe Ala Leu Ser Arg
Lys Val 785 790 795 800 Ile Gly Ser Ser Glu Leu Ser Ile Asp Glu Ser
Glu Thr Val Ile Arg 805 810 815 Glu Thr Tyr Ser Glu Thr Asp Lys Asn
Asp Asn Ser Arg Tyr Lys Met 820 825 830 Ser Ser Ser Phe Leu Gly Ser
Gln Lys Asn Val Ser Pro Gly Phe Ile 835 840 845 Lys Ile Gln Gln Pro
Val Glu Glu Glu Ser Glu Leu Asp Leu Glu Leu 850 855 860 Glu Ser Glu
Gln Glu Ala Gly Leu Gly Leu Asp Leu Asp Leu Asp Arg 865 870 875 880
Glu Leu Glu Pro Glu Met Glu Pro Lys Ala Glu Thr Glu Thr Lys Thr 885
890 895 Gln Thr Glu Met Glu Pro Gln Pro Glu Thr Glu Pro Glu Met Glu
Pro 900 905 910 Asn Pro Lys Ser Arg Pro Arg Ala His Thr Phe Pro Gln
Gln Arg Tyr 915 920 925 Trp Pro Met Tyr His Pro Ser Met Ala Ser Thr
Gln Ser Gln Thr Gln 930 935 940 Thr Arg Thr Trp Ser Val Glu Arg Arg
Arg His Pro Met Asp Ser Tyr 945 950 955 960 Ser Pro Glu Gly Asn Ser
Asn Glu Asp Val 965 970 77225PRTHomo sapiens 77Met Thr Ser Glu Phe
Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 1 5 10 15 Asp Thr Thr
His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 20 25 30 Asp
Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 35 40
45 Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val
50 55 60 Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp
Asp Phe 65 70 75 80 Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro
Pro Ser Pro Ala 85 90 95 Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu
Ser Ser Met Cys Pro Thr 100 105 110 Ile Met Val Gly Gln Asp Gly Gln
Val Arg Met Val Val Gly Ala Ala 115 120 125 Gly Gly Thr Gln Ile Thr
Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 130 135 140 Leu Trp Phe Gly
Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 145 150 155 160 His
Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 165 170
175 Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile
180 185 190 Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met
Ala Gly 195 200 205 Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly
Glu Pro Ala Gly 210 215 220 Tyr 225 78225PRTHomo sapiens 78Met Thr
Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 1 5 10 15
Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 20
25 30 Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly
Ser 35 40 45 Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly
Ser Lys Val 50 55 60 Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn
Glu Met Asp Asp Phe 65 70 75 80 Ser Ser Thr Ser Ile Thr Asn Glu Phe
Gly Val Pro Pro Ser Pro Ala 85 90 95 Asn Phe Ile Gln Pro Gly Lys
Gln Pro Leu Ser Ser Met Cys Pro Thr 100 105 110 Ile Met Val Gly Gln
Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 115 120 125 Gly Gly Thr
Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 130 135 140 Leu
Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 145 150
155 160 His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile
Asp 165 170 175 Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His
Thr Gln Ile 180 185 190 Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile
Val Arg Met Ala Gly 195 200 205 Gly Trp Ala Ala Ala Ser Asp Ser Arg
Lys Gly Gly Glu Pro Ala Gly 210 215 220 Tyr 225 79225PRTHomo
sapiens 79Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile
Ser Asp 1 5 10 15 Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu
Phe Tyr Met Pro 20 25 30 Asp Asp Gly Gly Thr Ala His Leu Ser Val
Val Ala Glu Asp Gly Ser 35 40 45 Ala Val Ser Ala Thr Ser Thr Ile
Asn Leu Tyr Phe Gly Ser Lys Val 50 55 60 Arg Ser Pro Val Ser Gly
Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 65 70 75 80 Ser Ser Thr Ser
Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 85 90 95 Asn Phe
Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 100 105 110
Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 115
120 125 Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr
Asn 130 135 140 Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu
Pro Arg Leu 145 150 155 160 His Asn Gln Leu Leu Pro Asn Val Thr Thr
Val Glu Arg Asn Ile Asp 165 170 175 Gln Glu Val Thr Ala Ala Leu Glu
Thr Arg His His His Thr Gln Ile 180 185 190 Thr Ser Thr Phe Ile Ala
Val Val Gln Ala Ile Val Arg Met Ala Gly 195 200 205 Gly Trp Ala Ala
Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 210 215 220 Tyr 225
80545PRTHomo sapiens 80Met Gly Ser Ser Ala Thr Glu Ile Glu Glu Leu
Glu Asn Thr Thr Phe 1 5 10 15 Lys Tyr Leu Thr Gly Glu Gln Thr Glu
Lys Met Trp Gln Arg Leu Lys 20 25 30 Gly Ile Leu Arg Cys Leu Val
Lys Gln Leu Glu Arg Gly Asp Val Asn 35 40 45 Val Val Asp Leu Lys
Lys Asn Ile Glu Tyr Ala Ala Ser Val Leu Glu 50 55 60 Ala Val Tyr
Ile Asp Glu Thr Arg Arg Leu Leu Asp Thr Glu Asp Glu 65 70 75 80 Leu
Ser Asp Ile Gln Thr Asp Ser Val Pro Ser Glu Val Arg Asp Trp 85 90
95 Leu Ala Ser Thr Phe Thr Arg Lys Met Gly Met Thr Lys Lys Lys Pro
100 105 110 Glu Glu Lys Pro Lys Phe Arg Ser Ile Val His Ala Val Gln
Ala Gly 115 120 125 Ile Phe Val Glu Arg Met Tyr Arg Lys Thr Tyr His
Met Val Gly Leu 130 135 140 Ala Tyr Pro Ala Ala Val Ile Val Thr Leu
Lys Asp Val Asp Lys Trp 145 150 155 160 Ser Phe Asp Val Phe Ala Leu
Asn Glu Ala Ser Gly Glu His Ser Leu 165 170 175 Lys Phe Met Ile Tyr
Glu Leu Phe Thr Arg Tyr Asp Leu Ile Asn Arg 180 185 190 Phe Lys Ile
Pro Val Ser Cys Leu Ile Thr Phe Ala Glu Ala Leu Glu 195 200 205 Val
Gly Tyr Ser Lys Tyr Lys Asn Pro Tyr His Asn Leu Ile His Ala 210 215
220 Ala Asp Val Thr Gln Thr Val His Tyr Ile Met Leu His Thr Gly Ile
225 230 235 240 Met His Trp Leu Thr Glu Leu Glu Ile Leu Ala Met Val
Phe Ala Ala 245 250 255 Ala Ile His Asp Tyr Glu His Thr Gly Thr Thr
Asn Asn Phe His Ile 260 265 270 Gln Thr Arg Ser Asp Val Ala Ile Leu
Tyr Asn Asp Arg Ser Val Leu 275 280 285 Glu Asn His His Val Ser Ala
Ala Tyr Arg Leu Met Gln Glu Glu Glu 290 295 300 Met Asn Ile Leu Ile
Asn Leu Ser Lys Asp Asp Trp Arg Asp Leu Arg 305 310 315 320 Asn Leu
Val Ile Glu Met Val Leu Ser Thr Asp Met Ser Gly His Phe 325 330 335
Gln Gln Ile Lys Asn Ile Arg Asn Ser Leu Gln Gln Pro Glu Gly Ile 340
345 350 Asp Arg Ala Lys Thr Met Ser Leu Ile Leu His Ala Ala Asp Ile
Ser 355 360 365 His Pro Ala Lys Ser Trp Lys Leu His Tyr Arg Trp Thr
Met Ala Leu 370 375 380 Met Glu Glu Phe Phe Leu Gln Gly Asp Lys Glu
Ala Glu Leu Gly Leu 385 390 395 400 Pro Phe Ser Pro Leu Cys Asp Arg
Lys Ser Thr Met Val Ala Gln Ser 405 410 415 Gln Ile Gly Phe Ile Asp
Phe Ile Val Glu Pro Thr Phe Ser Leu Leu 420 425 430 Thr Asp Ser Thr
Glu Lys Ile Val Ile Pro Leu Ile Glu Glu Ala Ser 435 440 445 Lys Ala
Glu Thr Ser Ser Tyr Val Ala Ser Ser Ser Thr Thr Ile Val 450 455 460
Gly Leu His Ile Ala Asp Ala Leu Arg Arg Ser Asn Thr Lys Gly Ser 465
470 475 480 Met Ser Asp Gly Ser Tyr Ser Pro Asp Tyr Ser Leu Ala Ala
Val Asp 485 490 495 Leu Lys Ser Phe Lys Asn Asn Leu Val Asp Ile Ile
Gln Gln Asn Lys 500 505
510 Glu Arg Trp Lys Glu Leu Ala Ala Gln Gly Glu Ser Asp Leu His Lys
515 520 525 Asn Ser Glu Asp Leu Val Asn Ala Glu Glu Lys His Asp Glu
Thr His 530 535 540 Ser 545 81535PRTHomo sapiens 81Met Gly Ser Ser
Ala Thr Glu Ile Glu Glu Leu Glu Asn Thr Thr Phe 1 5 10 15 Lys Tyr
Leu Thr Gly Glu Gln Thr Glu Lys Met Trp Gln Arg Leu Lys 20 25 30
Gly Ile Leu Arg Cys Leu Val Lys Gln Leu Glu Arg Gly Asp Val Asn 35
40 45 Val Val Asp Leu Lys Lys Asn Ile Glu Tyr Ala Ala Ser Val Leu
Glu 50 55 60 Ala Val Tyr Ile Asp Glu Thr Arg Arg Leu Leu Asp Thr
Glu Asp Glu 65 70 75 80 Leu Ser Asp Ile Gln Thr Asp Ser Val Pro Ser
Glu Val Arg Asp Trp 85 90 95 Leu Ala Ser Thr Phe Thr Arg Lys Met
Gly Met Thr Lys Lys Lys Pro 100 105 110 Glu Glu Lys Pro Lys Phe Arg
Ser Ile Val His Ala Val Gln Ala Gly 115 120 125 Ile Phe Val Glu Arg
Met Tyr Arg Lys Thr Tyr His Met Val Gly Leu 130 135 140 Ala Tyr Pro
Ala Ala Val Ile Val Thr Leu Lys Asp Val Asp Lys Trp 145 150 155 160
Ser Phe Asp Val Phe Ala Leu Asn Glu Ala Ser Gly Glu His Ser Leu 165
170 175 Lys Phe Met Ile Tyr Glu Leu Phe Thr Arg Tyr Asp Leu Ile Asn
Arg 180 185 190 Phe Lys Ile Pro Val Ser Cys Leu Ile Thr Phe Ala Glu
Ala Leu Glu 195 200 205 Val Gly Tyr Ser Lys Tyr Lys Asn Pro Tyr His
Asn Leu Ile His Ala 210 215 220 Ala Asp Val Thr Gln Thr Val His Tyr
Ile Met Leu His Thr Gly Ile 225 230 235 240 Met His Trp Leu Thr Glu
Leu Glu Ile Leu Ala Met Val Phe Ala Ala 245 250 255 Ala Ile His Asp
Tyr Glu His Thr Gly Thr Thr Asn Asn Phe His Ile 260 265 270 Gln Thr
Arg Ser Asp Val Ala Ile Leu Tyr Asn Asp Arg Ser Val Leu 275 280 285
Glu Asn His His Val Ser Ala Ala Tyr Arg Leu Met Gln Glu Glu Glu 290
295 300 Met Asn Ile Leu Ile Asn Leu Ser Lys Asp Asp Trp Arg Asp Leu
Arg 305 310 315 320 Asn Leu Val Ile Glu Met Val Leu Ser Thr Asp Met
Ser Gly His Phe 325 330 335 Gln Gln Ile Lys Asn Ile Arg Asn Ser Leu
Gln Gln Pro Glu Gly Ile 340 345 350 Asp Arg Ala Lys Thr Met Ser Leu
Ile Leu His Ala Ala Asp Ile Ser 355 360 365 His Pro Ala Lys Ser Trp
Lys Leu His Tyr Arg Trp Thr Met Ala Leu 370 375 380 Met Glu Glu Phe
Phe Leu Gln Gly Asp Lys Glu Ala Glu Leu Gly Leu 385 390 395 400 Pro
Phe Ser Pro Leu Cys Asp Arg Lys Ser Thr Met Val Ala Gln Ser 405 410
415 Gln Ile Gly Phe Ile Asp Phe Ile Val Glu Pro Thr Phe Ser Leu Leu
420 425 430 Thr Asp Ser Thr Glu Lys Ile Val Ile Pro Leu Ile Glu Glu
Ala Ser 435 440 445 Lys Ala Glu Thr Ser Ser Tyr Val Ala Ser Ser Ser
Thr Thr Ile Val 450 455 460 Gly Leu His Ile Ala Asp Ala Leu Arg Arg
Ser Asn Thr Lys Gly Ser 465 470 475 480 Met Ser Asp Gly Ser Tyr Ser
Pro Asp Tyr Ser Leu Ala Ala Val Asp 485 490 495 Leu Lys Ser Phe Lys
Asn Asn Leu Val Asp Ile Ile Gln Gln Asn Lys 500 505 510 Glu Arg Trp
Lys Glu Leu Ala Ala Gln Glu Ala Arg Thr Ser Ser Gln 515 520 525 Lys
Cys Glu Phe Ile His Gln 530 535 82729PRTHomo sapiens 82Met Asn Pro
Phe Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 1 5 10 15 Val
Ser Ile Glu Glu Val Pro Pro Arg Pro Pro Ser Pro Pro Lys Lys 20 25
30 Pro Ser Pro Thr Ile Cys Gly Ser Asn Tyr Pro Leu Ser Ile Ala Phe
35 40 45 Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly
Met Lys 50 55 60 Ala Val Leu Ile Leu Tyr Phe Leu Tyr Phe Leu His
Trp Asn Glu Asp 65 70 75 80 Thr Ser Thr Ser Ile Tyr His Ala Phe Ser
Ser Leu Cys Tyr Phe Thr 85 90 95 Pro Ile Leu Gly Ala Ala Ile Ala
Asp Ser Trp Leu Gly Lys Phe Lys 100 105 110 Thr Ile Ile Tyr Leu Ser
Leu Val Tyr Val Leu Gly His Val Ile Lys 115 120 125 Ser Leu Gly Ala
Leu Pro Ile Leu Gly Gly Gln Val Val His Thr Val 130 135 140 Leu Ser
Leu Ile Gly Leu Ser Leu Ile Ala Leu Gly Thr Gly Gly Ile 145 150 155
160 Lys Pro Cys Val Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Lys His
165 170 175 Ala Glu Glu Arg Thr Arg Tyr Phe Ser Val Phe Tyr Leu Ser
Ile Asn 180 185 190 Ala Gly Ser Leu Ile Ser Thr Phe Ile Thr Pro Met
Leu Arg Gly Asp 195 200 205 Val Gln Cys Phe Gly Glu Asp Cys Tyr Ala
Leu Ala Phe Gly Val Pro 210 215 220 Gly Leu Leu Met Val Ile Ala Leu
Val Val Phe Ala Met Gly Ser Lys 225 230 235 240 Ile Tyr Asn Lys Pro
Pro Pro Glu Gly Asn Ile Val Ala Gln Val Phe 245 250 255 Lys Cys Ile
Trp Phe Ala Ile Ser Asn Arg Phe Lys Asn Arg Ser Gly 260 265 270 Asp
Ile Pro Lys Arg Gln His Trp Leu Asp Trp Ala Ala Glu Lys Tyr 275 280
285 Pro Lys Gln Leu Ile Met Asp Val Lys Ala Leu Thr Arg Val Leu Phe
290 295 300 Leu Tyr Ile Pro Leu Pro Met Phe Trp Ala Leu Leu Asp Gln
Gln Gly 305 310 315 320 Ser Arg Trp Thr Leu Gln Ala Ile Arg Met Asn
Arg Asn Leu Gly Phe 325 330 335 Phe Val Leu Gln Pro Asp Gln Met Gln
Val Leu Asn Pro Leu Leu Val 340 345 350 Leu Ile Phe Ile Pro Leu Phe
Asp Phe Val Ile Tyr Arg Leu Val Ser 355 360 365 Lys Cys Gly Ile Asn
Phe Ser Ser Leu Arg Lys Met Ala Val Gly Met 370 375 380 Ile Leu Ala
Cys Leu Ala Phe Ala Val Ala Ala Ala Val Glu Ile Lys 385 390 395 400
Ile Asn Glu Met Ala Pro Ala Gln Pro Gly Pro Gln Glu Val Phe Leu 405
410 415 Gln Val Leu Asn Leu Ala Asp Asp Glu Val Lys Val Thr Val Val
Gly 420 425 430 Asn Glu Asn Asn Ser Leu Leu Ile Glu Ser Ile Lys Ser
Phe Gln Lys 435 440 445 Thr Pro His Tyr Ser Lys Leu His Leu Lys Thr
Lys Ser Gln Asp Phe 450 455 460 His Phe His Leu Lys Tyr His Asn Leu
Ser Leu Tyr Thr Glu His Ser 465 470 475 480 Val Gln Glu Lys Asn Trp
Tyr Ser Leu Val Ile Arg Glu Asp Gly Asn 485 490 495 Ser Ile Ser Ser
Met Met Val Lys Asp Thr Glu Ser Arg Thr Thr Asn 500 505 510 Gly Met
Thr Thr Val Arg Phe Val Asn Thr Leu His Lys Asp Val Asn 515 520 525
Ile Ser Leu Ser Thr Asp Thr Ser Leu Asn Val Gly Glu Asp Tyr Gly 530
535 540 Val Ser Ala Tyr Arg Thr Val Gln Arg Gly Glu Tyr Pro Ala Val
His 545 550 555 560 Cys Arg Thr Glu Asp Lys Asn Phe Ser Leu Asn Leu
Gly Leu Leu Asp 565 570 575 Phe Gly Ala Ala Tyr Leu Phe Val Ile Thr
Asn Asn Thr Asn Gln Gly 580 585 590 Leu Gln Ala Trp Lys Ile Glu Asp
Ile Pro Ala Asn Lys Met Ser Ile 595 600 605 Ala Trp Gln Leu Pro Gln
Tyr Ala Leu Val Thr Ala Gly Glu Val Met 610 615 620 Phe Ser Val Thr
Gly Leu Glu Phe Ser Tyr Ser Gln Ala Pro Ser Gly 625 630 635 640 Met
Lys Ser Val Leu Gln Ala Ala Trp Leu Leu Thr Ile Ala Val Gly 645 650
655 Asn Ile Ile Val Leu Val Val Ala Gln Phe Ser Gly Leu Val Gln Trp
660 665 670 Ala Glu Phe Ile Leu Phe Ser Cys Leu Leu Leu Val Ile Cys
Leu Ile 675 680 685 Phe Ser Ile Met Gly Tyr Tyr Tyr Val Pro Val Lys
Thr Glu Asp Met 690 695 700 Arg Gly Pro Ala Asp Lys His Ile Pro His
Ile Gln Gly Asn Met Ile 705 710 715 720 Lys Leu Glu Thr Lys Lys Thr
Lys Leu 725 838RNAArtificial SequenceSynthetic oligonucleotide
83uugcuaua 88419DNAArtificial SequenceSynthetic oligonucleotide
84ttccatggta atggtgtgc 198519DNAArtificial SequenceSynthetic
oligonucleotide 85ccgaagcaag gaataatcc 198619DNAArtificial
SequenceSynthetic oligonucleotide 86tatgtttcgc ctttatgac
198719DNAArtificial SequenceSynthetic oligonucleotide 87ggattcaagg
aggaatgac 198819DNAArtificial SequenceSynthetic oligonucleotide
88ctccctcttg catcaagac 198919DNAArtificial SequenceSynthetic
oligonucleotide 89aaatcctcgt caggtttac 199019DNAArtificial
SequenceSynthetic oligonucleotide 90agtgccttac agtatcatc
199119DNAArtificial SequenceSynthetic oligonucleotide 91cctgaatgtg
actgtggac 199219DNAArtificial SequenceSynthetic oligonucleotide
92gactgactgg cctgaaggc 199319DNAArtificial SequenceSynthetic
oligonucleotide 93gcagcactat ttgaagcac 199419DNAArtificial
SequenceSynthetic oligonucleotide 94gcctgagaac ctcctctgc
199519DNAArtificial SequenceSynthetic oligonucleotide 95acagctagtc
aggcacttc 199619DNAArtificial SequenceSynthetic oligonucleotide
96tataagaaat ggcatactc 199719DNAArtificial SequenceSynthetic
oligonucleotide 97ctaatccatg gtctagttc 199819DNAArtificial
SequenceSynthetic oligonucleotide 98gtctgctata aggaatatc
199919DNAArtificial SequenceSynthetic oligonucleotide 99aagtactcct
gaggtctac 1910019DNAArtificial SequenceSynthetic oligonucleotide
100aggcaccagg gacttgtgc 1910119DNAArtificial SequenceSynthetic
oligonucleotide 101gatctacacc accttcatc 1910219DNAArtificial
SequenceSynthetic oligonucleotide 102tggtgttcta cgtggtgac
1910319DNAArtificial SequenceSynthetic oligonucleotide
103tgttaggcgc ctgcattgc 1910419DNAArtificial SequenceSynthetic
oligonucleotide 104caacatcttt atctgctcc 1910519DNAArtificial
SequenceSynthetic oligonucleotide 105cgaagggctt tcacaatgc
1910619DNAArtificial SequenceSynthetic oligonucleotide
106gtactacgtt gtagcccac 1910719DNAArtificial SequenceSynthetic
oligonucleotide 107tgcaggcgct taacattac 1910819DNAArtificial
SequenceSynthetic oligonucleotide 108ggtgtatggg ctcatgtac
1910919DNAArtificial SequenceSynthetic oligonucleotide
109catcgtcatc gcctgctac 1911019DNAArtificial SequenceSynthetic
oligonucleotide 110gctcatggtg cgcattggc 1911119DNAArtificial
SequenceSynthetic oligonucleotide 111gtaccttatg acgctgatc
1911219DNAArtificial SequenceSynthetic oligonucleotide
112acctggtatg ggtttggcc 1911319DNAArtificial SequenceSynthetic
oligonucleotide 113atgtgtgcag gtctactgc 1911419DNAArtificial
SequenceSynthetic oligonucleotide 114ttatttaggg cggtttaac
1911519DNAArtificial SequenceSynthetic oligonucleotide
115taatgtcatc gcctccaac 1911619DNAArtificial SequenceSynthetic
oligonucleotide 116agaactgggt gatgacagc 1911719DNAArtificial
SequenceSynthetic oligonucleotide 117caacagtccc tgctacatc
1911819DNAArtificial SequenceSynthetic oligonucleotide
118gatcgtggtg catccatac 1911919DNAArtificial SequenceSynthetic
oligonucleotide 119gcgtggatta ccagaagac 1912019DNAArtificial
SequenceSynthetic oligonucleotide 120taacaacagt ccctgctac
1912119DNAArtificial SequenceSynthetic oligonucleotide
121ccattgcttg gtgaatggc 1912219DNAArtificial SequenceSynthetic
oligonucleotide 122attctctcca tggagtgac 1912319DNAArtificial
SequenceSynthetic oligonucleotide 123atgaactctg tgatccagc
1912419DNAArtificial SequenceSynthetic oligonucleotide
124aggttggcta gtggatctc 1912519DNAArtificial SequenceSynthetic
oligonucleotide 125aagtgggtaa ttcctgctc 1912619DNAArtificial
SequenceSynthetic oligonucleotide 126cgaatggcag aatggatac
1912719DNAArtificial SequenceSynthetic oligonucleotide
127tctggcaggt tgcatattc 1912819DNAArtificial SequenceSynthetic
oligonucleotide 128ctgcaagttt catatctac 1912919DNAArtificial
SequenceSynthetic oligonucleotide 129atagcatcag attgtatgc
1913019DNAArtificial SequenceSynthetic oligonucleotide
130tttacacgat gatatgttc 1913119DNAArtificial SequenceSynthetic
oligonucleotide 131cagaggattt gccagaaac 1913219DNAArtificial
SequenceSynthetic oligonucleotide 132ttggaattcc agtgtaccc
1913319DNAArtificial SequenceSynthetic oligonucleotide
133cagagacacc atctccctc 1913419DNAArtificial SequenceSynthetic
oligonucleotide 134acccagaccc aaagtttgc 1913519DNAArtificial
SequenceSynthetic oligonucleotide 135aaggtggaaa gactatctc
1913619DNAArtificial SequenceSynthetic oligonucleotide
136tataaaccag aggatttgc 1913719DNAArtificial SequenceSynthetic
oligonucleotide 137gtataatcta catcagatc
1913819DNAArtificial SequenceSynthetic oligonucleotide
138ccacatgttt accagagac 1913919DNAArtificial SequenceSynthetic
oligonucleotide 139gctagttatc gcctacctc 1914019DNAArtificial
SequenceSynthetic oligonucleotide 140gacacacagg agttcaacc
1914119DNAArtificial SequenceSynthetic oligonucleotide
141gctgcagaaa ctaggcatc 1914219DNAArtificial SequenceSynthetic
oligonucleotide 142tgccaacttc tacaaggac 1914319DNAArtificial
SequenceSynthetic oligonucleotide 143cgacacacag gagttcaac
1914419DNAArtificial SequenceSynthetic oligonucleotide
144gatggacgtc aagtctgcc 1914519DNAArtificial SequenceSynthetic
oligonucleotide 145acaggagttc aacctcagc 1914619DNAArtificial
SequenceSynthetic oligonucleotide 146ttggcatgga accaacgac
1914719DNAArtificial SequenceSynthetic oligonucleotide
147cctctttgcc ctgtatgac 1914819DNAArtificial SequenceSynthetic
oligonucleotide 148agattccaga tgcaacccc 1914919DNAArtificial
SequenceSynthetic oligonucleotide 149catgagccag ctgagtttc
1915019DNAArtificial SequenceSynthetic oligonucleotide
150gtggaagtga tcttctatc 1915119DNAArtificial SequenceSynthetic
oligonucleotide 151tggctgtcat ggtccaatc 1915219DNAArtificial
SequenceSynthetic oligonucleotide 152ccgctgcatg aactatgac
1915319DNAArtificial SequenceSynthetic oligonucleotide
153ttggagactt cggtttaac 1915419DNAArtificial SequenceSynthetic
oligonucleotide 154tgtgattcag attctagtc 1915519DNAArtificial
SequenceSynthetic oligonucleotide 155agtggatgtc ctacatctc
1915619DNAArtificial SequenceSynthetic oligonucleotide
156atcatgcagg atgacatgc 1915719DNAArtificial SequenceSynthetic
oligonucleotide 157ctgaactact ggtacagcc 1915819DNAArtificial
SequenceSynthetic oligonucleotide 158cagctttacg tcctgagtc
1915919DNAArtificial SequenceSynthetic oligonucleotide
159tcagaccaca agagagacc 1916019DNAArtificial SequenceSynthetic
oligonucleotide 160gtacctacag tggatgtcc 1916119DNAArtificial
SequenceSynthetic oligonucleotide 161tggtcaagga gatactgac
1916219DNAArtificial SequenceSynthetic oligonucleotide
162ccctccagtc atgttcttc 1916319DNAArtificial SequenceSynthetic
oligonucleotide 163ttctgcaact gtgatgatc 1916419DNAArtificial
SequenceSynthetic oligonucleotide 164gtacactacg tggattcac
1916519DNAArtificial SequenceSynthetic oligonucleotide
165gcgaattcca ccagcattc 1916619DNAArtificial SequenceSynthetic
oligonucleotide 166tcttccagtg ctgcagctc 1916719DNAArtificial
SequenceSynthetic oligonucleotide 167tcagaacaag aggctgggc
1916819DNAArtificial SequenceSynthetic oligonucleotide
168gaagattgcc agtcttcac 1916919DNAArtificial SequenceSynthetic
oligonucleotide 169gattcctcct ctcaacatc 1917019DNAArtificial
SequenceSynthetic oligonucleotide 170gcattctagt atttctaac
1917119DNAArtificial SequenceSynthetic oligonucleotide
171ttacagtgtc aattccaac 1917219DNAArtificial SequenceSynthetic
oligonucleotide 172tgattatcgg gagatcatc 1917319DNAArtificial
SequenceSynthetic oligonucleotide 173gaatggatgt gtatgtatc
1917419DNAArtificial SequenceSynthetic oligonucleotide
174tgacatgatt ccttatagc 1917519DNAArtificial SequenceSynthetic
oligonucleotide 175tctacacact gccaaatgc 1917619DNAArtificial
SequenceSynthetic oligonucleotide 176actggccatc atctacaac
1917719DNAArtificial SequenceSynthetic oligonucleotide
177tgctcacctg tctgtggtc 1917819DNAArtificial SequenceSynthetic
oligonucleotide 178acattgacca ggaagtgac 1917919DNAArtificial
SequenceSynthetic oligonucleotide 179tggatgactt cagctctac
1918019DNAArtificial SequenceSynthetic oligonucleotide
180ctacaacctc tggttcggc 1918119DNAArtificial SequenceSynthetic
oligonucleotide 181cacgacagtg gagagaaac 1918219DNAArtificial
SequenceSynthetic oligonucleotide 182gttctacatg ccggatgac
1918319DNAArtificial SequenceSynthetic oligonucleotide
183aggtatcatg cactggctc 1918419DNAArtificial SequenceSynthetic
oligonucleotide 184gaagctgaat tagggcttc 1918519DNAArtificial
SequenceSynthetic oligonucleotide 185ctggtggaca tcattcagc
1918619DNAArtificial SequenceSynthetic oligonucleotide
186tttgtgatcg gaagtcaac 1918719DNAArtificial SequenceSynthetic
oligonucleotide 187attgctgatg cactaagac 1918819DNAArtificial
SequenceSynthetic oligonucleotide 188cagatatgat cttatcaac
1918919DNAArtificial SequenceSynthetic oligonucleotide
189actgtgcatt acataatgc 1919019DNAArtificial SequenceSynthetic
oligonucleotide 190cacgtgagtg cagcttatc 1919119DNAArtificial
SequenceSynthetic oligonucleotide 191agtcctatca ttgatcggc
1919219DNAArtificial SequenceSynthetic oligonucleotide
192gaagccatct ccgacaatc 1919319DNAArtificial SequenceSynthetic
oligonucleotide 193atggctgttg gtatgatcc 1919419DNAArtificial
SequenceSynthetic oligonucleotide 194ccgtgaggtt tgttaacac
1919519DNAArtificial SequenceSynthetic oligonucleotide
195ttgggtgcct taccaatac 1919619DNAArtificial SequenceSynthetic
oligonucleotide 196ctccaagtgt ggaattaac 1919719DNAArtificial
SequenceSynthetic oligonucleotide 197gcatgatggt aaaggatac
19198109PRTHomo sapiens 198Met Ile Cys Cys Ser Ala Leu Ser Pro Arg
Ile His Leu Ser Phe His 1 5 10 15 Arg Ser Leu Thr Gly Ile Val Leu
Ala Asn Ser Ser Leu Asp Ile Val 20 25 30 Leu His Asp Thr Tyr Tyr
Val Val Ala His Cys Gly Gly Asn Val Arg 35 40 45 Arg Leu His Cys
Gly Gly Pro Ala Ser Arg Glu Arg Thr Ala Met Gln 50 55 60 Ala Leu
Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg Asp His 65 70 75 80
Asn Leu Thr Arg Glu Gln Phe Ile Ala Leu Tyr Arg Leu Arg Pro Leu 85
90 95 Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu Ala 100 105
19923PRTHomo sapiens 199Leu Val Leu Thr Gly Val Leu Ile Phe Ala Leu
Ala Leu Phe Gly Asn 1 5 10 15 Ala Leu Val Phe Tyr Val Val 20
20011PRTHomo sapiens 200Thr Arg Ser Lys Ala Met Arg Thr Val Thr Asn
1 5 10 20123PRTHomo sapiens 201Ile Phe Ile Cys Ser Leu Ala Leu Ser
Asp Leu Leu Ile Thr Phe Phe 1 5 10 15 Cys Ile Pro Val Thr Met Leu
20 20214PRTHomo sapiens 202Gln Asn Ile Ser Asp Asn Trp Leu Gly Gly
Ala Phe Ile Cys 1 5 10 20323PRTHomo sapiens 203Lys Met Val Pro Phe
Val Gln Ser Thr Ala Val Val Thr Glu Ile Leu 1 5 10 15 Thr Met Thr
Cys Ile Ala Val 20 20420PRTHomo sapiens 204Glu Arg His Gln Gly Leu
Val His Pro Phe Lys Met Lys Trp Gln Tyr 1 5 10 15 Thr Asn Arg Arg
20 20523PRTHomo sapiens 205Ala Phe Thr Met Leu Gly Val Val Trp Leu
Val Ala Val Ile Val Gly 1 5 10 15 Ser Pro Met Trp His Val Gln 20
20648PRTHomo sapiens 206Gln Leu Glu Ile Lys Tyr Asp Phe Leu Tyr Glu
Lys Glu His Ile Cys 1 5 10 15 Cys Leu Glu Glu Trp Thr Ser Pro Val
His Gln Lys Ile Tyr Thr Thr 20 25 30 Phe Ile Leu Ser Ser Ser Ser
Ser Cys Leu Leu Trp Lys Lys Lys Arg 35 40 45 20723PRTHomo sapiens
207Ala Val Ile Met Met Val Thr Val Val Ala Leu Phe Ala Val Cys Trp
1 5 10 15 Ala Pro Phe His Val Val His 20 20819PRTHomo sapiens
208Met Met Ile Glu Tyr Ser Asn Phe Glu Lys Glu Tyr Asp Asp Val Thr
1 5 10 15 Ile Lys Met 20923PRTHomo sapiens 209Ile Phe Ala Ile Val
Gln Ile Ile Gly Phe Ser Asn Ser Ile Cys Asn 1 5 10 15 Pro Ile Val
Tyr Ala Phe Met 20 21096PRTHomo sapiens 210Asn Glu Asn Phe Lys Lys
Asn Val Leu Ser Ala Val Cys Tyr Cys Ile 1 5 10 15 Val Asn Lys Thr
Phe Ser Pro Ala Gln Arg His Gly Asn Ser Gly Ile 20 25 30 Thr Met
Met Arg Lys Lys Ala Lys Phe Ser Leu Arg Glu Asn Pro Val 35 40 45
Glu Glu Thr Lys Gly Glu Ala Phe Ser Asp Gly Asn Ile Glu Val Lys 50
55 60 Leu Cys Glu Gln Thr Glu Glu Lys Lys Lys Leu Lys Arg His Leu
Ala 65 70 75 80 Leu Phe Arg Ser Glu Leu Ala Glu Asn Ser Pro Leu Asp
Ser Gly His 85 90 95 21147PRTHomo sapiens 211Met Gln Ala Leu Asn
Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg 1 5 10 15 Asp His Asn
Leu Thr Arg Glu Gln Phe Ile Ala Val His Arg Leu Arg 20 25 30 Pro
Leu Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu Ala 35 40 45
21223PRTHomo sapiens 212Leu Val Leu Thr Gly Val Leu Ile Phe Ala Leu
Ala Leu Phe Gly Asn 1 5 10 15 Ala Leu Val Phe Tyr Val Val 20
21311PRTHomo sapiens 213Thr Arg Ser Lys Ala Met Arg Thr Val Thr Asn
1 5 10 21423PRTHomo sapiens 214Ile Phe Ile Cys Ser Leu Ala Leu Ser
Asp Leu Leu Ile Thr Phe Phe 1 5 10 15 Cys Ile Pro Val Thr Met Leu
20 21514PRTHomo sapiens 215Gln Asn Ile Ser Asp Asn Trp Leu Gly Gly
Ala Phe Ile Cys 1 5 10 21623PRTHomo sapiens 216Lys Met Val Pro Phe
Val Gln Ser Thr Ala Val Val Thr Glu Ile Leu 1 5 10 15 Thr Met Thr
Cys Ile Ala Val 20 21720PRTHomo sapiens 217Glu Arg His Gln Gly Leu
Val His Pro Phe Lys Met Lys Trp Gln Tyr 1 5 10 15 Thr Asn Arg Arg
20 21823PRTHomo sapiens 218Ala Phe Thr Met Leu Gly Val Val Trp Leu
Val Ala Val Ile Val Gly 1 5 10 15 Ser Pro Met Trp His Val Gln 20
21928PRTHomo sapiens 219Gln Leu Glu Ile Lys Tyr Asp Phe Leu Tyr Glu
Lys Glu His Ile Cys 1 5 10 15 Cys Leu Glu Glu Trp Thr Ser Pro Val
His Gln Lys 20 25 22023PRTHomo sapiens 220Ile Tyr Thr Thr Phe Ile
Leu Val Ile Leu Phe Leu Leu Pro Leu Met 1 5 10 15 Val Met Leu Ile
Leu Tyr Ser 20 22134PRTHomo sapiens 221Lys Ile Gly Tyr Glu Leu Trp
Ile Lys Lys Arg Val Gly Asp Gly Ser 1 5 10 15 Val Leu Arg Thr Ile
His Gly Lys Glu Met Ser Lys Ile Ala Arg Lys 20 25 30 Lys Lys
22223PRTHomo sapiens 222Arg Ala Val Ile Met Met Val Thr Val Val Ala
Leu Phe Ala Val Cys 1 5 10 15 Trp Ala Pro Phe His Val Val 20
22319PRTHomo sapiens 223His Met Met Ile Glu Tyr Ser Asn Phe Glu Lys
Glu Tyr Asp Asp Val 1 5 10 15 Thr Ile Lys 22423PRTHomo sapiens
224Met Ile Phe Ala Ile Val Gln Ile Ile Gly Phe Ser Asn Ser Ile Cys
1 5 10 15 Asn Pro Ile Val Tyr Ala Phe 20 22597PRTHomo sapiens
225Met Asn Glu Asn Phe Lys Lys Asn Val Leu Ser Ala Val Cys Tyr Cys
1 5 10 15 Ile Val Asn Lys Thr Phe Ser Pro Ala Gln Arg His Gly Asn
Ser Gly 20 25 30 Ile Thr Met Met Arg Lys Lys Ala Lys Phe Ser Leu
Arg Glu Asn Pro 35 40 45 Val Glu Glu Thr Lys Gly Glu Ala Phe Ser
Asp Gly Asn Ile Glu Val 50 55 60 Lys Leu Cys Glu Gln Thr Glu Glu
Lys Lys Lys Leu Lys Arg His Leu 65 70 75 80 Ala Leu Phe Arg Ser Glu
Leu Ala Glu Asn Ser Pro Leu Asp Ser Gly 85 90 95 His 226320PRTHomo
sapiens 226Met Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly
Gly Gly 1 5 10 15 Ala Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala
Arg Leu Ala Glu 20 25 30 Glu Gly Ser Gly Asp Ala Gly Gly Arg Arg
Arg Pro Pro Val Asp Pro 35 40 45 Arg Arg Leu Ala Arg Gln Leu Leu
Leu Leu Leu Trp Leu Leu Glu Ala 50 55 60 Pro Leu Leu Leu Gly Val
Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly 65 70 75 80 Gln Gly Pro Gly
Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln 85 90 95 Gln Ser
Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp 100 105 110
His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala 115
120 125 Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln
Glu 130 135 140 Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val
Lys Val Gln 145 150 155 160 Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys
Ser Met Tyr Ala Pro Val 165 170 175 Cys Thr Val Leu Glu Gln Ala Leu
Pro Pro Cys Arg Ser Leu Cys Glu 180 185 190 Arg Ala Arg Gln Gly Cys
Glu Ala Leu Met Asn Lys Phe Gly Phe Gln 195 200 205 Trp Pro Asp Thr
Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly 210 215 220
Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro 225
230 235 240 Ser Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly
Gly Gly 245 250 255 Gly His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala
Ser Glu Arg Gly 260 265 270 Lys Phe Ser Cys Pro Arg Ala Leu Lys Val
Pro Ser Tyr Leu Asn Tyr 275 280 285 His Phe Leu Gly Glu Lys Asp Cys
Gly Ala Pro Cys Glu Pro Thr Lys 290 295 300 Val Tyr Gly Leu Met Tyr
Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 305 310 315 320
22723PRTHomo sapiens 227Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys
Ala Ser Thr Leu Phe 1 5 10 15 Thr Val Leu Thr Tyr Leu Val 20
22812PRTHomo sapiens 228Asp Met Arg Arg Phe Ser Tyr Pro Glu Arg Pro
Ile 1 5 10 22920PRTHomo sapiens 229Ile Phe Leu Ser Gly Cys Tyr Thr
Ala Val Ala Val Ala Tyr Ile Ala 1 5 10 15 Gly Phe Leu Leu 20
23027PRTHomo sapiens 230Glu Asp Arg Val Val Cys Asn Asp Lys Phe Ala
Glu Asp Gly Ala Arg 1 5 10 15 Thr Val Ala Gln Gly Thr Lys Lys Glu
Gly Cys 20 25 23123PRTHomo sapiens 231Thr Ile Leu Phe Met Met Leu
Tyr Phe Phe Ser Met Ala Ser Ser Ile 1 5 10 15 Trp Trp Val Ile Leu
Ser Leu 20 23220PRTHomo sapiens 232Thr Trp Phe Leu Ala Ala Gly Met
Lys Trp Gly His Glu Ala Ile Glu 1 5 10 15 Ala Asn Ser Gln 20
23323PRTHomo sapiens 233Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala
Ile Lys Thr Ile Thr 1 5 10 15 Ile Leu Ala Leu Gly Gln Val 20
23423PRTHomo sapiens 234Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val
Gly Leu Asn Asn Val 1 5 10 15 Asp Ala Leu Arg Gly Phe Val 20
23523PRTHomo sapiens 235Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly
Thr Ser Phe Leu Leu 1 5 10 15 Ala Gly Phe Val Ser Leu Phe 20
23620PRTHomo sapiens 236Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr
Lys Thr Glu Lys Leu 1 5 10 15 Glu Lys Leu Met 20 23723PRTHomo
sapiens 237Val Arg Ile Gly Val Phe Ser Val Leu Tyr Thr Val Pro Ala
Thr Ile 1 5 10 15 Val Ile Ala Cys Tyr Phe Tyr 20 23842PRTHomo
sapiens 238Glu Gln Ala Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala
Gln Ser 1 5 10 15 Cys Lys Ser Tyr Ala Ile Pro Cys Pro His Leu Gln
Ala Gly Gly Gly 20 25 30 Ala Pro Pro His Pro Pro Met Ser Pro Asp 35
40 23923PRTHomo sapiens 239Phe Thr Val Phe Met Ile Lys Tyr Leu Met
Thr Leu Ile Val Gly Ile 1 5 10 15 Thr Ser Gly Phe Trp Ile Trp 20
24025PRTHomo sapiens 240Ser Gly Lys Thr Leu Asn Ser Trp Arg Lys Phe
Tyr Thr Arg Leu Thr 1 5 10 15 Asn Ser Lys Gln Gly Glu Thr Thr Val
20 25 241409PRTHomo sapiens 241Met Ala Cys Leu Met Ala Ala Phe Ser
Val Gly Thr Ala Met Asn Ala 1 5 10 15 Ser Ser Tyr Ser Ala Glu Met
Thr Glu Pro Lys Ser Val Cys Val Ser 20 25 30 Val Asp Glu Val Val
Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 35 40 45 Leu Asn Gly
His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 50 55 60 Arg
Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 65 70
75 80 Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys
Gly 85 90 95 Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn
Ser Gly Glu 100 105 110 Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly
Lys Ser Thr Leu Met 115 120 125 Asn Ile Leu Ala Gly Tyr Arg Glu Thr
Gly Met Lys Gly Ala Val Leu 130 135 140 Ile Asn Gly Leu Pro Arg Asp
Leu Arg Cys Phe Arg Lys Val Ser Cys 145 150 155 160 Tyr Ile Met Gln
Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 165 170 175 Ala Met
Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 180 185 190
Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 195
200 205 Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys
Arg 210 215 220 Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val
Met Phe Phe 225 230 235 240 Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala
Ser Cys Phe Gln Val Val 245 250 255 Ser Leu Met Lys Gly Leu Ala Gln
Gly Gly Arg Ser Ile Ile Cys Thr 260 265 270 Ile His Gln Pro Ser Ala
Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 275 280 285 Val Leu Ser Gln
Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 290 295 300 Val Pro
Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 305 310 315
320 Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln
325 330 335 Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp
Ser Asp 340 345 350 His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn
Pro Phe Leu Trp 355 360 365 His Arg Pro Ser Glu Glu Asp Ser Ser Ser
Met Glu Gly Cys His Ser 370 375 380 Phe Ser Ala Ser Cys Leu Thr Gln
Phe Cys Ile Leu Phe Lys Arg Thr 385 390 395 400 Phe Leu Ser Ile Met
Arg Asp Ser Val 405 24223PRTHomo sapiens 242Leu Thr His Leu Arg Ile
Thr Ser His Ile Gly Ile Gly Leu Leu Ile 1 5 10 15 Gly Leu Leu Tyr
Leu Gly Ile 20 24312PRTHomo sapiens 243Gly Asn Glu Ala Lys Lys Val
Leu Ser Asn Ser Gly 1 5 10 24423PRTHomo sapiens 244Phe Leu Phe Phe
Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro 1 5 10 15 Thr Val
Leu Thr Phe Pro Leu 20 24523PRTHomo sapiens 245Glu Met Gly Val Phe
Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 1 5 10 15 Lys Ala Tyr
Tyr Leu Ala Lys 20 24623PRTHomo sapiens 246Thr Met Ala Asp Val Pro
Phe Gln Ile Met Phe Pro Val Ala Tyr Cys 1 5 10 15 Ser Ile Val Tyr
Trp Met Thr 20 2476PRTHomo sapiens 247Ser Gln Pro Ser Asp Ala 1 5
24823PRTHomo sapiens 248Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr
Met Thr Ser Leu Val 1 5 10 15 Ala Gln Ser Leu Gly Leu Leu 20
2499PRTHomo sapiens 249Ile Gly Ala Ala Ser Thr Ser Leu Gln 1 5
25023PRTHomo sapiens 250Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile
Pro Val Leu Leu Phe 1 5 10 15 Ser Gly Phe Phe Val Ser Phe 20
25112PRTHomo sapiens 251Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser
Tyr 1 5 10 25218PRTHomo sapiens 252Ile Ser Tyr Val Arg Tyr Gly Phe
Glu Gly Val Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu 25331PRTHomo
sapiens 253Asp Arg Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His
Phe Gln 1 5 10 15 Lys Ser Glu Ala Ile Leu Arg Glu Leu Asp Val Glu
Asn Ala Lys 20 25 30 25423PRTHomo sapiens 254Leu Tyr Leu Asp Phe
Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg 1 5 10 15 Leu Ile Ala
Tyr Phe Val Leu 20 2558PRTHomo sapiens 255Arg Tyr Lys Ile Arg Ala
Glu Arg 1 5 256421PRTHomo sapiens 256Met Ala Cys Leu Met Ala Ala
Phe Ser Val Gly Thr Ala Met Asn Ala 1 5 10 15 Ser Ser Tyr Ser Ala
Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 20 25 30 Val Asp Glu
Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 35 40 45 Leu
Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 50 55
60 Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg
65 70 75 80 Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys
Lys Gly 85 90 95 Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe
Asn Ser Gly Glu 100 105 110 Leu Val Ala Ile Met Gly Pro Ser Gly Ala
Gly Lys Ser Thr Leu Met 115 120 125 Asn Ile Leu Ala Gly Tyr Arg Glu
Thr Gly Met Lys Gly Ala Val Leu 130 135 140 Ile Asn Gly Leu Pro Arg
Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 145 150 155 160 Tyr Ile Met
Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 165 170 175 Ala
Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 180 185
190 Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser
195 200 205 Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg
Lys Arg 210 215 220 Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro
Val Met Phe Phe 225 230 235 240 Asp Glu Pro Thr Ser Gly Leu Asp Ser
Ala Ser Cys Phe Gln Val Val 245 250 255 Ser Leu Met Lys Gly Leu Ala
Gln Gly Gly Arg Ser Ile Ile Cys Thr 260 265 270 Ile His Gln Pro Ser
Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 275 280 285 Val Leu Ser
Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 290 295 300 Val
Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 305 310
315 320 Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp
Gln 325 330 335 Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys
Asp Ser Asp 340 345 350 His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val
Asn Pro Phe Leu Trp 355 360 365 His Arg Pro Ser Glu Glu Val Lys Gln
Thr Lys Arg Leu Lys Gly Leu 370 375 380 Arg Lys Asp Ser Ser Ser Met
Glu Gly Cys His Ser Phe Ser Ala Ser 385 390 395 400 Cys Leu Thr Gln
Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile 405 410 415 Met Arg
Asp Ser Val 420 25723PRTHomo sapiens 257Leu Thr His Leu Arg Ile Thr
Ser His Ile Gly Ile Gly Leu Leu Ile 1 5 10 15 Gly Leu Leu Tyr Leu
Gly Ile 20 25812PRTHomo sapiens 258Gly Asn Glu Ala Lys Lys Val Leu
Ser Asn Ser Gly 1 5 10 25923PRTHomo sapiens 259Phe Leu Phe Phe Ser
Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro 1 5 10 15 Thr Val Leu
Thr Phe Pro Leu 20 26023PRTHomo sapiens 260Glu Met Gly Val Phe Leu
Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 1 5 10 15 Lys Ala Tyr Tyr
Leu Ala Lys 20 26123PRTHomo sapiens 261Thr Met Ala Asp Val Pro Phe
Gln Ile Met Phe Pro Val Ala Tyr Cys 1 5 10 15 Ser Ile Val Tyr Trp
Met Thr 20 2626PRTHomo sapiens 262Ser Gln Pro Ser Asp Ala 1 5
26323PRTHomo sapiens 263Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr
Met Thr Ser Leu Val 1 5 10 15 Ala Gln Ser Leu Gly Leu Leu 20
2649PRTHomo sapiens 264Ile Gly Ala Ala Ser Thr Ser Leu Gln 1 5
26523PRTHomo sapiens 265Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile
Pro Val Leu Leu Phe 1 5 10 15 Ser Gly Phe Phe Val Ser Phe 20
26612PRTHomo sapiens 266Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser
Tyr 1 5 10 26718PRTHomo sapiens 267Ile Ser Tyr Val Arg Tyr Gly Phe
Glu Gly Val Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu 26831PRTHomo
sapiens 268Asp Arg Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His
Phe Gln 1 5 10 15 Lys Ser Glu Ala Ile Leu Arg Glu Leu Asp Val Glu
Asn Ala Lys 20 25 30 26923PRTHomo sapiens 269Leu Tyr Leu Asp Phe
Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg 1 5 10 15 Leu Ile Ala
Tyr Phe Val Leu 20 2708PRTHomo sapiens 270Arg Tyr Lys Ile Arg Ala
Glu Arg 1 5 271420PRTHomo sapiens 271Met Arg Ile Ser Leu Pro Arg
Ala Pro Glu Arg Asp Gly Gly Val Ser 1 5 10 15 Ala Ser Ser Leu Leu
Asp Thr Val Thr Asn Ala Ser Ser Tyr Ser Ala 20 25 30 Glu Met Thr
Glu Pro Lys Ser Val Cys Val Ser Val Asp Glu Val Val 35 40 45 Ser
Ser Asn Met Glu Ala Thr Glu Thr Asp Leu Leu Asn Gly His Leu 50 55
60 Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser Ser Leu
65 70 75 80 Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser
Tyr Ser 85 90 95 Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr
Lys Thr Leu Leu 100 105 110 Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly
Glu Leu Val Ala Ile Met 115 120 125 Gly Pro Ser Gly Ala Gly Lys Ser
Thr Leu Met Asn Ile Leu Ala Gly 130 135 140 Tyr Arg Glu Thr Gly Met
Lys Gly Ala Val Leu Ile Asn Gly Leu Pro 145 150 155 160 Arg Asp Leu
Arg Cys Phe Arg Lys Val Ser Cys Tyr Ile Met Gln Asp 165 170 175 Asp
Met Leu Leu Pro His Leu Thr Val Gln Glu Ala Met Met Val Ser 180 185
190 Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu Met Val
195 200 205 Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn
Thr Arg 210 215 220 Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu
Ala Ile Ala Leu 225 230 235 240 Glu Leu Val Asn Asn Pro Pro Val Met
Phe Phe Asp Glu Pro Thr Ser 245 250 255 Gly Leu Asp Ser Ala Ser Cys
Phe Gln Val Val Ser Leu Met Lys Gly 260 265 270 Leu Ala Gln Gly Gly
Arg Ser Ile Ile Cys Thr Ile His Gln Pro Ser 275 280 285 Ala Lys Leu
Phe Glu Leu Phe Asp Gln Leu Tyr Val Leu Ser Gln Gly 290 295 300 Gln
Cys Val Tyr Arg Gly Lys Val Cys Asn Leu Val Pro Tyr Leu Arg 305 310
315 320 Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp Phe
Val 325 330 335 Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser
Arg Leu Val 340 345 350 Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp
His Lys Arg Asp Leu 355 360 365 Gly Gly Asp Ala Glu Val Asn Pro Phe
Leu Trp His Arg Pro Ser Glu 370 375 380 Glu Asp Ser Ser Ser Met Glu
Gly Cys His Ser Phe Ser Ala Ser Cys 385
390 395 400 Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser
Ile Met 405 410 415 Arg Asp Ser Val 420 27223PRTHomo sapiens 272Leu
Thr His Leu Arg Ile Thr Ser His Ile Gly Ile Gly Leu Leu Ile 1 5 10
15 Gly Leu Leu Tyr Leu Gly Ile 20 27312PRTHomo sapiens 273Gly Asn
Glu Ala Lys Lys Val Leu Ser Asn Ser Gly 1 5 10 27423PRTHomo sapiens
274Phe Leu Phe Phe Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro
1 5 10 15 Thr Val Leu Thr Phe Pro Leu 20 27523PRTHomo sapiens
275Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu
1 5 10 15 Lys Ala Tyr Tyr Leu Ala Lys 20 27623PRTHomo sapiens
276Thr Met Ala Asp Val Pro Phe Gln Ile Met Phe Pro Val Ala Tyr Cys
1 5 10 15 Ser Ile Val Tyr Trp Met Thr 20 2776PRTHomo sapiens 277Ser
Gln Pro Ser Asp Ala 1 5 27823PRTHomo sapiens 278Val Arg Phe Val Leu
Phe Ala Ala Leu Gly Thr Met Thr Ser Leu Val 1 5 10 15 Ala Gln Ser
Leu Gly Leu Leu 20 2799PRTHomo sapiens 279Ile Gly Ala Ala Ser Thr
Ser Leu Gln 1 5 28023PRTHomo sapiens 280Val Ala Thr Phe Val Gly Pro
Val Thr Ala Ile Pro Val Leu Leu Phe 1 5 10 15 Ser Gly Phe Phe Val
Ser Phe 20 28112PRTHomo sapiens 281Asp Thr Ile Pro Thr Tyr Leu Gln
Trp Met Ser Tyr 1 5 10 28218PRTHomo sapiens 282Ile Ser Tyr Val Arg
Tyr Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu
28331PRTHomo sapiens 283Asp Arg Glu Asp Leu His Cys Asp Ile Asp Glu
Thr Cys His Phe Gln 1 5 10 15 Lys Ser Glu Ala Ile Leu Arg Glu Leu
Asp Val Glu Asn Ala Lys 20 25 30 28423PRTHomo sapiens 284Leu Tyr
Leu Asp Phe Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg 1 5 10 15
Leu Ile Ala Tyr Phe Val Leu 20 2858PRTHomo sapiens 285Arg Tyr Lys
Ile Arg Ala Glu Arg 1 5 286411PRTHomo sapiens 286Met Leu Gly Thr
Gln Gly Trp Thr Lys Gln Arg Lys Pro Cys Pro Gln 1 5 10 15 Asn Ala
Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys 20 25 30
Val Ser Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr 35
40 45 Asp Leu Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr
Glu 50 55 60 Ala Gln Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val
Asn Ile Glu 65 70 75 80 Phe Arg Asp Leu Ser Tyr Ser Val Pro Glu Gly
Pro Trp Trp Arg Lys 85 90 95 Lys Gly Tyr Lys Thr Leu Leu Lys Gly
Ile Ser Gly Lys Phe Asn Ser 100 105 110 Gly Glu Leu Val Ala Ile Met
Gly Pro Ser Gly Ala Gly Lys Ser Thr 115 120 125 Leu Met Asn Ile Leu
Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala 130 135 140 Val Leu Ile
Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 145 150 155 160
Ser Cys Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 165
170 175 Gln Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys
Asp 180 185 190 Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala
Leu Gly Leu 195 200 205 Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu
Ser Gly Gly Gln Arg 210 215 220 Lys Arg Leu Ala Ile Ala Leu Glu Leu
Val Asn Asn Pro Pro Val Met 225 230 235 240 Phe Phe Asp Glu Pro Thr
Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln 245 250 255 Val Val Ser Leu
Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile 260 265 270 Cys Thr
Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 275 280 285
Leu Tyr Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 290
295 300 Asn Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr
Tyr 305 310 315 320 His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser
Gly Glu Tyr Gly 325 330 335 Asp Gln Asn Ser Arg Leu Val Arg Ala Val
Arg Glu Gly Met Cys Asp 340 345 350 Ser Asp His Lys Arg Asp Leu Gly
Gly Asp Ala Glu Val Asn Pro Phe 355 360 365 Leu Trp His Arg Pro Ser
Glu Glu Asp Ser Ser Ser Met Glu Gly Cys 370 375 380 His Ser Phe Ser
Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys 385 390 395 400 Arg
Thr Phe Leu Ser Ile Met Arg Asp Ser Val 405 410 28723PRTHomo
sapiens 287Leu Thr His Leu Arg Ile Thr Ser His Ile Gly Ile Gly Leu
Leu Ile 1 5 10 15 Gly Leu Leu Tyr Leu Gly Ile 20 28812PRTHomo
sapiens 288Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly 1 5 10
28923PRTHomo sapiens 289Phe Leu Phe Phe Ser Met Leu Phe Leu Met Phe
Ala Ala Leu Met Pro 1 5 10 15 Thr Val Leu Thr Phe Pro Leu 20
29023PRTHomo sapiens 290Glu Met Gly Val Phe Leu Arg Glu His Leu Asn
Tyr Trp Tyr Ser Leu 1 5 10 15 Lys Ala Tyr Tyr Leu Ala Lys 20
29123PRTHomo sapiens 291Thr Met Ala Asp Val Pro Phe Gln Ile Met Phe
Pro Val Ala Tyr Cys 1 5 10 15 Ser Ile Val Tyr Trp Met Thr 20
2926PRTHomo sapiens 292Ser Gln Pro Ser Asp Ala 1 5 29323PRTHomo
sapiens 293Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr Ser
Leu Val 1 5 10 15 Ala Gln Ser Leu Gly Leu Leu 20 2949PRTHomo
sapiens 294Ile Gly Ala Ala Ser Thr Ser Leu Gln 1 5 29523PRTHomo
sapiens 295Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val Leu
Leu Phe 1 5 10 15 Ser Gly Phe Phe Val Ser Phe 20 29612PRTHomo
sapiens 296Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr 1 5 10
29718PRTHomo sapiens 297Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly Val
Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu 29831PRTHomo sapiens 298Asp
Arg Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln 1 5 10
15 Lys Ser Glu Ala Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys 20
25 30 29923PRTHomo sapiens 299Leu Tyr Leu Asp Phe Ile Val Leu Gly
Ile Phe Phe Ile Ser Leu Arg 1 5 10 15 Leu Ile Ala Tyr Phe Val Leu
20 3008PRTHomo sapiens 300Arg Tyr Lys Ile Arg Ala Glu Arg 1 5
301387PRTHomo sapiens 301Met Thr Glu Pro Lys Ser Val Cys Val Ser
Val Asp Glu Val Val Ser 1 5 10 15 Ser Asn Met Glu Ala Thr Glu Thr
Asp Leu Leu Asn Gly His Leu Lys 20 25 30 Lys Val Asp Asn Asn Leu
Thr Glu Ala Gln Arg Phe Ser Ser Leu Pro 35 40 45 Arg Arg Ala Ala
Val Asn Ile Glu Phe Arg Asp Leu Ser Tyr Ser Val 50 55 60 Pro Glu
Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr Leu Leu Lys 65 70 75 80
Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala Ile Met Gly 85
90 95 Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn Ile Leu Ala Gly
Tyr 100 105 110 Arg Glu Thr Gly Met Lys Gly Ala Val Leu Ile Asn Gly
Leu Pro Arg 115 120 125 Asp Leu Arg Cys Phe Arg Lys Val Ser Cys Tyr
Ile Met Gln Asp Asp 130 135 140 Met Leu Leu Pro His Leu Thr Val Gln
Glu Ala Met Met Val Ser Ala 145 150 155 160 His Leu Lys Leu Gln Glu
Lys Asp Glu Gly Arg Arg Glu Met Val Lys 165 170 175 Glu Ile Leu Thr
Ala Leu Gly Leu Leu Ser Cys Ala Asn Thr Arg Thr 180 185 190 Gly Ser
Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile Ala Leu Glu 195 200 205
Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu Pro Thr Ser Gly 210
215 220 Leu Asp Ser Ala Ser Cys Phe Gln Val Val Ser Leu Met Lys Gly
Leu 225 230 235 240 Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr Ile His
Gln Pro Ser Ala 245 250 255 Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr
Val Leu Ser Gln Gly Gln 260 265 270 Cys Val Tyr Arg Gly Lys Val Cys
Asn Leu Val Pro Tyr Leu Arg Asp 275 280 285 Leu Gly Leu Asn Cys Pro
Thr Tyr His Asn Pro Ala Asp Phe Val Met 290 295 300 Glu Val Ala Ser
Gly Glu Tyr Gly Asp Gln Asn Ser Arg Leu Val Arg 305 310 315 320 Ala
Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg Asp Leu Gly 325 330
335 Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg Pro Ser Glu Glu
340 345 350 Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser
Cys Leu 355 360 365 Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu
Ser Ile Met Arg 370 375 380 Asp Ser Val 385 30223PRTHomo sapiens
302Leu Thr His Leu Arg Ile Thr Ser His Ile Gly Ile Gly Leu Leu Ile
1 5 10 15 Gly Leu Leu Tyr Leu Gly Ile 20 30312PRTHomo sapiens
303Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly 1 5 10
30423PRTHomo sapiens 304Phe Leu Phe Phe Ser Met Leu Phe Leu Met Phe
Ala Ala Leu Met Pro 1 5 10 15 Thr Val Leu Thr Phe Pro Leu 20
30523PRTHomo sapiens 305Glu Met Gly Val Phe Leu Arg Glu His Leu Asn
Tyr Trp Tyr Ser Leu 1 5 10 15 Lys Ala Tyr Tyr Leu Ala Lys 20
30623PRTHomo sapiens 306Thr Met Ala Asp Val Pro Phe Gln Ile Met Phe
Pro Val Ala Tyr Cys 1 5 10 15 Ser Ile Val Tyr Trp Met Thr 20
3076PRTHomo sapiens 307Ser Gln Pro Ser Asp Ala 1 5 30823PRTHomo
sapiens 308Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr Ser
Leu Val 1 5 10 15 Ala Gln Ser Leu Gly Leu Leu 20 3099PRTHomo
sapiens 309Ile Gly Ala Ala Ser Thr Ser Leu Gln 1 5 31023PRTHomo
sapiens 310Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val Leu
Leu Phe 1 5 10 15 Ser Gly Phe Phe Val Ser Phe 20 31112PRTHomo
sapiens 311Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr 1 5 10
31218PRTHomo sapiens 312Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly Val
Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu 31331PRTHomo sapiens 313Asp
Arg Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln 1 5 10
15 Lys Ser Glu Ala Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys 20
25 30 31423PRTHomo sapiens 314Leu Tyr Leu Asp Phe Ile Val Leu Gly
Ile Phe Phe Ile Ser Leu Arg 1 5 10 15 Leu Ile Ala Tyr Phe Val Leu
20 3158PRTHomo sapiens 315Arg Tyr Lys Ile Arg Ala Glu Arg 1 5
316406PRTHomo sapiens 316Met Ile Met Arg Leu Pro Gln Pro His Gly
Thr Asn Ala Ser Ser Tyr 1 5 10 15 Ser Ala Glu Met Thr Glu Pro Lys
Ser Val Cys Val Ser Val Asp Glu 20 25 30 Val Val Ser Ser Asn Met
Glu Ala Thr Glu Thr Asp Leu Leu Asn Gly 35 40 45 His Leu Lys Lys
Val Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser 50 55 60 Ser Leu
Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser 65 70 75 80
Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr 85
90 95 Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val
Ala 100 105 110 Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met
Asn Ile Leu 115 120 125 Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala
Val Leu Ile Asn Gly 130 135 140 Leu Pro Arg Asp Leu Arg Cys Phe Arg
Lys Val Ser Cys Tyr Ile Met 145 150 155 160 Gln Asp Asp Met Leu Leu
Pro His Leu Thr Val Gln Glu Ala Met Met 165 170 175 Val Ser Ala His
Leu Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu 180 185 190 Met Val
Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn 195 200 205
Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile 210
215 220 Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu
Pro 225 230 235 240 Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val
Val Ser Leu Met 245 250 255 Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile
Ile Cys Thr Ile His Gln 260 265 270 Pro Ser Ala Lys Leu Phe Glu Leu
Phe Asp Gln Leu Tyr Val Leu Ser 275 280 285 Gln Gly Gln Cys Val Tyr
Arg Gly Lys Val Cys Asn Leu Val Pro Tyr 290 295 300 Leu Arg Asp Leu
Gly Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp 305 310 315 320 Phe
Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg 325 330
335 Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg
340 345 350 Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His
Arg Pro 355 360 365 Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His
Ser Phe Ser Ala 370 375 380 Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe
Lys Arg Thr Phe Leu Ser 385 390 395 400 Ile Met Arg Asp Ser Val 405
31723PRTHomo sapiens 317Leu Thr His Leu Arg Ile Thr Ser His Ile Gly
Ile Gly Leu Leu Ile 1 5 10 15 Gly Leu Leu Tyr Leu Gly Ile 20
31812PRTHomo sapiens 318Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser
Gly 1 5 10 31923PRTHomo sapiens 319Phe Leu Phe Phe Ser Met Leu Phe
Leu Met Phe Ala Ala Leu Met Pro 1 5 10 15 Thr Val Leu Thr Phe Pro
Leu 20 32023PRTHomo sapiens 320Glu Met Gly Val Phe Leu Arg Glu His
Leu Asn Tyr Trp Tyr Ser Leu 1 5 10 15 Lys Ala Tyr Tyr Leu Ala Lys
20 32123PRTHomo sapiens 321Thr Met Ala Asp Val Pro Phe Gln Ile Met
Phe Pro Val Ala Tyr Cys 1 5 10 15 Ser Ile Val Tyr Trp Met Thr 20
3226PRTHomo sapiens 322Ser Gln Pro Ser Asp Ala 1 5 32323PRTHomo
sapiens 323Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr Ser
Leu Val 1 5 10 15 Ala Gln Ser Leu Gly Leu Leu 20
3249PRTHomo sapiens 324Ile Gly Ala Ala Ser Thr Ser Leu Gln 1 5
32523PRTHomo sapiens 325Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile
Pro Val Leu Leu Phe 1 5 10 15 Ser Gly Phe Phe Val Ser Phe 20
32612PRTHomo sapiens 326Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser
Tyr 1 5 10 32718PRTHomo sapiens 327Ile Ser Tyr Val Arg Tyr Gly Phe
Glu Gly Val Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu 32831PRTHomo
sapiens 328Asp Arg Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His
Phe Gln 1 5 10 15 Lys Ser Glu Ala Ile Leu Arg Glu Leu Asp Val Glu
Asn Ala Lys 20 25 30 32923PRTHomo sapiens 329Leu Tyr Leu Asp Phe
Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg 1 5 10 15 Leu Ile Ala
Tyr Phe Val Leu 20 3308PRTHomo sapiens 330Arg Tyr Lys Ile Arg Ala
Glu Arg 1 5 331567PRTHomo sapiens 331Met Leu Ala Val Gln Gln Thr
Glu His Leu Pro Ala Cys Pro Pro Ala 1 5 10 15 Arg Arg Trp Ser Ser
Asn Phe Cys Pro Glu Ser Thr Glu Gly Gly Pro 20 25 30 Ser Leu Leu
Gly Leu Arg Asp Met Val Arg Arg Gly Trp Ser Val Cys 35 40 45 Thr
Ala Ile Leu Leu Ala Arg Leu Trp Cys Leu Val Pro Thr His Thr 50 55
60 Phe Leu Ser Glu Tyr Pro Glu Ala Ala Glu Tyr Pro His Pro Gly Trp
65 70 75 80 Val Tyr Trp Leu Gln Met Ala Val Ala Pro Gly His Leu Arg
Ala Trp 85 90 95 Val Met Arg Asn Asn Val Thr Thr Asn Ile Pro Ser
Ala Phe Ser Gly 100 105 110 Thr Leu Thr His Glu Glu Lys Ala Val Leu
Thr Val Phe Thr Gly Thr 115 120 125 Ala Thr Ala Val His Val Gln Val
Ala Ala Leu Ala Ser Ala Lys Leu 130 135 140 Glu Ser Ser Val Phe Val
Thr Asp Cys Val Ser Cys Lys Ile Glu Asn 145 150 155 160 Val Cys Asp
Ser Ala Leu Gln Gly Lys Arg Val Pro Met Ser Gly Leu 165 170 175 Gln
Gly Ser Ser Ile Val Ile Met Pro Pro Ser Asn Arg Pro Leu Ala 180 185
190 Ser Ala Ala Ser Cys Thr Trp Ser Val Gln Val Gln Gly Gly Pro His
195 200 205 His Leu Gly Val Val Ala Ile Ser Gly Lys Val Leu Ser Ala
Ala His 210 215 220 Gly Ala Gly Arg Ala Tyr Gly Trp Gly Phe Pro Gly
Asp Pro Met Glu 225 230 235 240 Glu Gly Tyr Lys Thr Leu Leu Lys Gly
Ile Ser Gly Lys Phe Asn Ser 245 250 255 Gly Glu Leu Val Ala Ile Met
Gly Pro Ser Gly Ala Gly Lys Ser Thr 260 265 270 Leu Met Asn Ile Leu
Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala 275 280 285 Val Leu Ile
Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 290 295 300 Ser
Cys Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 305 310
315 320 Gln Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys
Asp 325 330 335 Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala
Leu Gly Leu 340 345 350 Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu
Ser Gly Gly Gln Arg 355 360 365 Lys Arg Leu Ala Ile Ala Leu Glu Leu
Val Asn Asn Pro Pro Val Met 370 375 380 Phe Phe Asp Glu Pro Thr Ser
Gly Leu Asp Ser Ala Ser Cys Phe Gln 385 390 395 400 Val Val Ser Leu
Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile 405 410 415 Cys Thr
Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 420 425 430
Leu Tyr Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 435
440 445 Asn Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr
Tyr 450 455 460 His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly
Glu Tyr Gly 465 470 475 480 Asp Gln Asn Ser Arg Leu Val Arg Ala Val
Arg Glu Gly Met Cys Asp 485 490 495 Ser Asp His Lys Arg Asp Leu Gly
Gly Asp Ala Glu Val Asn Pro Phe 500 505 510 Leu Trp His Arg Pro Ser
Glu Glu Val Lys Gln Thr Lys Arg Leu Lys 515 520 525 Gly Leu Arg Lys
Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser 530 535 540 Ala Ser
Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu 545 550 555
560 Ser Ile Met Arg Asp Ser Val 565 33223PRTHomo sapiens 332Leu Thr
His Leu Arg Ile Thr Ser His Ile Gly Ile Gly Leu Leu Ile 1 5 10 15
Gly Leu Leu Tyr Leu Gly Ile 20 33312PRTHomo sapiens 333Gly Asn Glu
Ala Lys Lys Val Leu Ser Asn Ser Gly 1 5 10 33423PRTHomo sapiens
334Phe Leu Phe Phe Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro
1 5 10 15 Thr Val Leu Thr Phe Pro Leu 20 33523PRTHomo sapiens
335Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu
1 5 10 15 Lys Ala Tyr Tyr Leu Ala Lys 20 33623PRTHomo sapiens
336Thr Met Ala Asp Val Pro Phe Gln Ile Met Phe Pro Val Ala Tyr Cys
1 5 10 15 Ser Ile Val Tyr Trp Met Thr 20 3376PRTHomo sapiens 337Ser
Gln Pro Ser Asp Ala 1 5 33823PRTHomo sapiens 338Val Arg Phe Val Leu
Phe Ala Ala Leu Gly Thr Met Thr Ser Leu Val 1 5 10 15 Ala Gln Ser
Leu Gly Leu Leu 20 3399PRTHomo sapiens 339Ile Gly Ala Ala Ser Thr
Ser Leu Gln 1 5 34023PRTHomo sapiens 340Val Ala Thr Phe Val Gly Pro
Val Thr Ala Ile Pro Val Leu Leu Phe 1 5 10 15 Ser Gly Phe Phe Val
Ser Phe 20 34112PRTHomo sapiens 341Asp Thr Ile Pro Thr Tyr Leu Gln
Trp Met Ser Tyr 1 5 10 34218PRTHomo sapiens 342Ile Ser Tyr Val Arg
Tyr Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr 1 5 10 15 Gly Leu
34331PRTHomo sapiens 343Asp Arg Glu Asp Leu His Cys Asp Ile Asp Glu
Thr Cys His Phe Gln 1 5 10 15 Lys Ser Glu Ala Ile Leu Arg Glu Leu
Asp Val Glu Asn Ala Lys 20 25 30 34423PRTHomo sapiens 344Leu Tyr
Leu Asp Phe Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg 1 5 10 15
Leu Ile Ala Tyr Phe Val Leu 20 3458PRTHomo sapiens 345Arg Tyr Lys
Ile Arg Ala Glu Arg 1 5 34690PRTHomo sapiens 346Met Ala Gln Leu Glu
Arg Ser Ala Ile Ser Gly Phe Ser Ser Lys Ser 1 5 10 15 Arg Arg Asn
Ser Phe Ala Tyr Asp Val Lys Arg Glu Val Tyr Asn Glu 20 25 30 Glu
Thr Phe Gln Gln Glu His Lys Arg Lys Ala Ser Ser Ser Gly Asn 35 40
45 Met Asn Ile Asn Ile Thr Thr Phe Arg His His Val Gln Cys Arg Cys
50 55 60 Ser Trp His Arg Phe Leu Arg Cys Val Leu Thr Ile Phe Pro
Phe Leu 65 70 75 80 Glu Trp Met Cys Met Tyr Arg Leu Lys Asp 85 90
34723PRTHomo sapiens 347Trp Leu Leu Gly Asp Leu Leu Ala Gly Ile Ser
Val Gly Leu Val Gln 1 5 10 15 Val Pro Gln Gly Leu Thr Leu 20
3485PRTHomo sapiens 348Ser Leu Leu Ala Arg 1 5 34923PRTHomo sapiens
349Gln Leu Ile Pro Pro Leu Asn Ile Ala Tyr Ala Ala Phe Cys Ser Ser
1 5 10 15 Val Ile Tyr Val Ile Phe Gly 20 3506PRTHomo sapiens 350Ser
Cys His Gln Met Ser 1 5 35120PRTHomo sapiens 351Ile Gly Ser Phe Phe
Leu Val Ser Ala Leu Leu Ile Asn Val Leu Lys 1 5 10 15 Val Ser Pro
Phe 20 35229PRTHomo sapiens 352Asn Asn Gly Gln Leu Val Met Gly Ser
Phe Val Lys Asn Glu Phe Ser 1 5 10 15 Ala Pro Ser Tyr Leu Met Gly
Tyr Asn Lys Ser Leu Ser 20 25 35323PRTHomo sapiens 353Val Val Ala
Thr Thr Thr Phe Leu Thr Gly Ile Ile Gln Leu Ile Met 1 5 10 15 Gly
Val Leu Gly Leu Gly Phe 20 35412PRTHomo sapiens 354Ile Ala Thr Tyr
Leu Pro Glu Ser Ala Met Ser Ala 1 5 10 35523PRTHomo sapiens 355Tyr
Leu Ala Ala Val Ala Leu His Ile Met Leu Ser Gln Leu Thr Phe 1 5 10
15 Ile Phe Gly Ile Met Ile Ser 20 35614PRTHomo sapiens 356Phe His
Ala Gly Pro Ile Ser Phe Phe Tyr Asp Ile Ile Asn 1 5 10 35723PRTHomo
sapiens 357Tyr Cys Val Ala Leu Pro Lys Ala Asn Ser Thr Ser Ile Leu
Val Phe 1 5 10 15 Leu Thr Val Val Val Ala Leu 20 35820PRTHomo
sapiens 358Arg Ile Asn Lys Cys Ile Arg Ile Ser Phe Asn Gln Tyr Pro
Ile Glu 1 5 10 15 Phe Pro Met Glu 20 35918PRTHomo sapiens 359Leu
Phe Leu Ile Ile Gly Phe Thr Val Ile Ala Asn Lys Ile Ser Met 1 5 10
15 Ala Thr 36027PRTHomo sapiens 360Glu Thr Ser Gln Thr Leu Ile Asp
Met Ile Pro Tyr Ser Phe Leu Leu 1 5 10 15 Pro Val Thr Pro Asp Phe
Ser Leu Leu Pro Lys 20 25 36120PRTHomo sapiens 361Ile Ile Leu Gln
Ala Phe Ser Leu Ser Leu Val Ser Ser Phe Leu Leu 1 5 10 15 Ile Phe
Leu Gly 20 36253PRTHomo sapiens 362Lys Lys Ile Ala Ser Leu His Asn
Tyr Ser Val Asn Ser Asn Gln Asp 1 5 10 15 Leu Ile Ala Ile Gly Leu
Cys Asn Val Val Ser Ser Phe Phe Arg Ser 20 25 30 Cys Val Phe Thr
Gly Ala Ile Ala Arg Thr Ile Ile Gln Asp Lys Ser 35 40 45 Gly Gly
Arg Gln Gln 50 36323PRTHomo sapiens 363Phe Ala Ser Leu Val Gly Ala
Gly Val Met Leu Leu Leu Met Val Lys 1 5 10 15 Met Gly His Phe Phe
Tyr Thr 20 3644PRTHomo sapiens 364Leu Pro Asn Ala 1 36520PRTHomo
sapiens 365Val Leu Ala Gly Ile Ile Leu Ser Asn Val Ile Pro Tyr Leu
Glu Thr 1 5 10 15 Ile Ser Asn Leu 20 36620PRTHomo sapiens 366Pro
Ser Leu Trp Arg Gln Asp Gln Tyr Asp Cys Ala Leu Trp Met Met 1 5 10
15 Thr Phe Ser Ser 20 36723PRTHomo sapiens 367Ser Ile Phe Leu Gly
Leu Asp Ile Gly Leu Ile Ile Ser Val Val Ser 1 5 10 15 Ala Phe Phe
Ile Thr Thr Val 20 368451PRTHomo sapiens 368Arg Ser His Arg Ala Lys
Ile Leu Leu Leu Gly Gln Ile Pro Asn Thr 1 5 10 15 Asn Ile Tyr Arg
Ser Ile Asn Asp Tyr Arg Glu Ile Ile Thr Ile Pro 20 25 30 Gly Val
Lys Ile Phe Gln Cys Cys Ser Ser Ile Thr Phe Val Asn Val 35 40 45
Tyr Tyr Leu Lys His Lys Leu Leu Lys Glu Val Asp Met Val Lys Val 50
55 60 Pro Leu Lys Glu Glu Glu Ile Phe Ser Leu Phe Asn Ser Ser Asp
Thr 65 70 75 80 Asn Leu Gln Gly Gly Lys Ile Cys Arg Cys Phe Cys Asn
Cys Asp Asp 85 90 95 Leu Glu Pro Leu Pro Arg Ile Leu Tyr Thr Glu
Arg Phe Glu Asn Lys 100 105 110 Leu Asp Pro Glu Ala Ser Ser Ile Asn
Leu Ile His Cys Ser His Phe 115 120 125 Glu Ser Met Asn Thr Ser Gln
Thr Ala Ser Glu Asp Gln Val Pro Tyr 130 135 140 Thr Val Ser Ser Val
Ser Gln Lys Asn Gln Gly Gln Gln Tyr Glu Glu 145 150 155 160 Val Glu
Glu Val Trp Leu Pro Asn Asn Ser Ser Arg Asn Ser Ser Pro 165 170 175
Gly Leu Pro Asp Val Ala Glu Ser Gln Gly Arg Arg Ser Leu Ile Pro 180
185 190 Tyr Ser Asp Ala Ser Leu Leu Pro Ser Val His Thr Ile Ile Leu
Asp 195 200 205 Phe Ser Met Val His Tyr Val Asp Ser Arg Gly Leu Val
Val Leu Arg 210 215 220 Gln Ile Cys Asn Ala Phe Gln Asn Ala Asn Ile
Leu Ile Leu Ile Ala 225 230 235 240 Gly Cys His Ser Ser Ile Val Arg
Ala Phe Glu Arg Asn Asp Phe Phe 245 250 255 Asp Ala Gly Ile Thr Lys
Thr Gln Leu Phe Leu Ser Val His Asp Ala 260 265 270 Val Leu Phe Ala
Leu Ser Arg Lys Val Ile Gly Ser Ser Glu Leu Ser 275 280 285 Ile Asp
Glu Ser Glu Thr Val Ile Arg Glu Thr Tyr Ser Glu Thr Asp 290 295 300
Lys Asn Asp Asn Ser Arg Tyr Lys Met Ser Ser Ser Phe Leu Gly Ser 305
310 315 320 Gln Lys Asn Val Ser Pro Gly Phe Ile Lys Ile Gln Gln Pro
Val Glu 325 330 335 Glu Glu Ser Glu Leu Asp Leu Glu Leu Glu Ser Glu
Gln Glu Ala Gly 340 345 350 Leu Gly Leu Asp Leu Asp Leu Asp Arg Glu
Leu Glu Pro Glu Met Glu 355 360 365 Pro Lys Ala Glu Thr Glu Thr Lys
Thr Gln Thr Glu Met Glu Pro Gln 370 375 380 Pro Glu Thr Glu Pro Glu
Met Glu Pro Asn Pro Lys Ser Arg Pro Arg 385 390 395 400 Ala His Thr
Phe Pro Gln Gln Arg Tyr Trp Pro Met Tyr His Pro Ser 405 410 415 Met
Ala Ser Thr Gln Ser Gln Thr Gln Thr Arg Thr Trp Ser Val Glu 420 425
430 Arg Arg Arg His Pro Met Asp Ser Tyr Ser Pro Glu Gly Asn Ser Asn
435 440 445 Glu Asp Val 450 36957PRTHomo sapiens 369Met Asn Pro Phe
Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 1 5 10 15 Val Ser
Ile Glu Glu Val Pro Pro Arg Pro Pro Ser Pro Pro Lys Lys 20 25 30
Pro Ser Pro Thr Ile Cys Gly Ser Asn Tyr Pro Leu Ser Ile Ala Phe 35
40 45 Ile Val Val Asn Glu Phe Cys Glu Arg 50 55 37018PRTHomo
sapiens 370Phe Ser Tyr Tyr Gly Met Lys Ala Val Leu Ile Leu Tyr Phe
Leu Tyr 1 5 10 15 Phe Leu 3719PRTHomo sapiens 371His Trp Asn Glu
Asp Thr Ser Thr Ser 1 5 37223PRTHomo sapiens 372Ile Tyr His Ala Phe
Ser Ser Leu Cys Tyr Phe Thr Pro Ile Leu Gly 1 5 10 15 Ala Ala Ile
Ala Asp Ser Trp 20 3736PRTHomo sapiens 373Leu Gly Lys Phe Lys Thr 1
5 37423PRTHomo sapiens 374Ile Ile Tyr Leu Ser Leu Val Tyr Val Leu
Gly His Val Ile Lys Ser 1 5 10 15 Leu Gly Ala Leu Pro Ile Leu 20
3753PRTHomo sapiens 375Gly Gly Gln 1 37623PRTHomo sapiens 376Val
Val His Thr Val Leu Ser Leu Ile Gly Leu Ser Leu Ile Ala Leu 1 5 10
15 Gly Thr Gly Gly Ile Lys Pro 20 37720PRTHomo sapiens 377Cys Val
Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Lys His Ala Glu 1 5 10 15
Glu Arg Thr Arg 20 37820PRTHomo sapiens 378Tyr Phe Ser Val Phe Tyr
Leu Ser Ile Asn Ala Gly Ser Leu Ile Ser 1 5 10 15 Thr Phe Ile Thr
20 37914PRTHomo sapiens 379Pro Met Leu Arg Gly Asp Val Gln Cys Phe
Gly
Glu Asp Cys 1 5 10 38020PRTHomo sapiens 380Tyr Ala Leu Ala Phe Gly
Val Pro Gly Leu Leu Met Val Ile Ala Leu 1 5 10 15 Val Val Phe Ala
20 38161PRTHomo sapiens 381Met Gly Ser Lys Ile Tyr Asn Lys Pro Pro
Pro Glu Gly Asn Ile Val 1 5 10 15 Ala Gln Val Phe Lys Cys Ile Trp
Phe Ala Ile Ser Asn Arg Phe Lys 20 25 30 Asn Arg Ser Gly Asp Ile
Pro Lys Arg Gln His Trp Leu Asp Trp Ala 35 40 45 Ala Glu Lys Tyr
Pro Lys Gln Leu Ile Met Asp Val Lys 50 55 60 38219PRTHomo sapiens
382Ala Leu Thr Arg Val Leu Phe Leu Tyr Ile Pro Leu Pro Met Phe Trp
1 5 10 15 Ala Leu Leu 38329PRTHomo sapiens 383Asp Gln Gln Gly Ser
Arg Trp Thr Leu Gln Ala Ile Arg Met Asn Arg 1 5 10 15 Asn Leu Gly
Phe Phe Val Leu Gln Pro Asp Gln Met Gln 20 25 38423PRTHomo sapiens
384Val Leu Asn Pro Leu Leu Val Leu Ile Phe Ile Pro Leu Phe Asp Phe
1 5 10 15 Val Ile Tyr Arg Leu Val Ser 20 38511PRTHomo sapiens
385Lys Cys Gly Ile Asn Phe Ser Ser Leu Arg Lys 1 5 10 38618PRTHomo
sapiens 386Met Ala Val Gly Met Ile Leu Ala Cys Leu Ala Phe Ala Val
Ala Ala 1 5 10 15 Ala Val 387250PRTHomo sapiens 387Glu Ile Lys Ile
Asn Glu Met Ala Pro Ala Gln Pro Gly Pro Gln Glu 1 5 10 15 Val Phe
Leu Gln Val Leu Asn Leu Ala Asp Asp Glu Val Lys Val Thr 20 25 30
Val Val Gly Asn Glu Asn Asn Ser Leu Leu Ile Glu Ser Ile Lys Ser 35
40 45 Phe Gln Lys Thr Pro His Tyr Ser Lys Leu His Leu Lys Thr Lys
Ser 50 55 60 Gln Asp Phe His Phe His Leu Lys Tyr His Asn Leu Ser
Leu Tyr Thr 65 70 75 80 Glu His Ser Val Gln Glu Lys Asn Trp Tyr Ser
Leu Val Ile Arg Glu 85 90 95 Asp Gly Asn Ser Ile Ser Ser Met Met
Val Lys Asp Thr Glu Ser Arg 100 105 110 Thr Thr Asn Gly Met Thr Thr
Val Arg Phe Val Asn Thr Leu His Lys 115 120 125 Asp Val Asn Ile Ser
Leu Ser Thr Asp Thr Ser Leu Asn Val Gly Glu 130 135 140 Asp Tyr Gly
Val Ser Ala Tyr Arg Thr Val Gln Arg Gly Glu Tyr Pro 145 150 155 160
Ala Val His Cys Arg Thr Glu Asp Lys Asn Phe Ser Leu Asn Leu Gly 165
170 175 Leu Leu Asp Phe Gly Ala Ala Tyr Leu Phe Val Ile Thr Asn Asn
Thr 180 185 190 Asn Gln Gly Leu Gln Ala Trp Lys Ile Glu Asp Ile Pro
Ala Asn Lys 195 200 205 Met Ser Ile Ala Trp Gln Leu Pro Gln Tyr Ala
Leu Val Thr Ala Gly 210 215 220 Glu Val Met Phe Ser Val Thr Gly Leu
Glu Phe Ser Tyr Ser Gln Ala 225 230 235 240 Pro Ser Gly Met Lys Ser
Val Leu Gln Ala 245 250 38823PRTHomo sapiens 388Ala Trp Leu Leu Thr
Ile Ala Val Gly Asn Ile Ile Val Leu Val Val 1 5 10 15 Ala Gln Phe
Ser Gly Leu Val 20 3894PRTHomo sapiens 389Gln Trp Ala Glu 1
39023PRTHomo sapiens 390Phe Ile Leu Phe Ser Cys Leu Leu Leu Val Ile
Cys Leu Ile Phe Ser 1 5 10 15 Ile Met Gly Tyr Tyr Tyr Val 20
39132PRTHomo sapiens 391Pro Val Lys Thr Glu Asp Met Arg Gly Pro Ala
Asp Lys His Ile Pro 1 5 10 15 His Ile Gln Gly Asn Met Ile Lys Leu
Glu Thr Lys Lys Thr Lys Leu 20 25 30 39219DNAArtificial
SequenceSynthetic oligonucleotide 392ataagcggtt atcactgcc
1939319DNAArtificial SequenceSynthetic oligonucleotide
393gctgggattc caagtggac 1939419DNAArtificial SequenceSynthetic
oligonucleotide 394aactgtgcag ggcctctcc 1939519DNAArtificial
SequenceSynthetic oligonucleotide 395gctgctggat gtcattcac
1939619DNAArtificial SequenceSynthetic oligonucleotide
396agagacacag tgcccatcc 1939719DNAArtificial SequenceSynthetic
oligonucleotide 397actgaacctc cgaaatgcc 1939819DNAArtificial
SequenceSynthetic oligonucleotide 398gtgctggagt gcttccatc
1939919DNAArtificial SequenceSynthetic oligonucleotide
399ttcagaccta ccttcagtc 1940019DNAArtificial SequenceSynthetic
oligonucleotide 400gagtcacaca gagatgagc 1940119DNAArtificial
SequenceSynthetic oligonucleotide 401cgatgtgcct tcaagattc
1940219DNAArtificial SequenceSynthetic oligonucleotide
402cagtggtttg ggaatctgc 1940319DNAArtificial SequenceSynthetic
oligonucleotide 403gtgactacac aaggactcc 1940419DNAArtificial
SequenceSynthetic oligonucleotide 404gactgattcg ctctttgcc
1940519DNAArtificial SequenceSynthetic oligonucleotide
405agtgcagcct tgtgggttc 1940619DNAArtificial SequenceSynthetic
oligonucleotide 406taacactcac tgcacctgc 1940719DNAArtificial
SequenceSynthetic oligonucleotide 407taactgaaac tcagctagc
1940819DNAArtificial SequenceSynthetic oligonucleotide
408actgaagtag ccctccttc 1940919DNAArtificial SequenceSynthetic
oligonucleotide 409agtgcagtac agcgatgac 1941019DNAArtificial
SequenceSynthetic oligonucleotide 410ttcacatcgc tgagcaccc
1941119DNAArtificial SequenceSynthetic oligonucleotide
411agccagcaac gacatgtac 1941219DNAArtificial SequenceSynthetic
oligonucleotide 412gctgctgggc atgtccttc 1941319DNAArtificial
SequenceSynthetic oligonucleotide 413tgtgatcgtc atcacagtc
1941419DNAArtificial SequenceSynthetic oligonucleotide
414aacatgatat gtgctggac 1941519DNAArtificial SequenceSynthetic
oligonucleotide 415ctgagaaggc ttccactgc 1941619DNAArtificial
SequenceSynthetic oligonucleotide 416tgatacgtgg atccaggcc
1941719DNAArtificial SequenceSynthetic oligonucleotide
417ctacagtgac aaggctaac 1941819DNAArtificial SequenceSynthetic
oligonucleotide 418gaactggata gccctcatc 1941919DNAArtificial
SequenceSynthetic oligonucleotide 419ccctggtaaa gctgcattc
1942019DNAArtificial SequenceSynthetic oligonucleotide
420gatgaaggct tcgggcttc 1942119DNAArtificial SequenceSynthetic
oligonucleotide 421tgtaaagctg gaaagggac 1942219DNAArtificial
SequenceSynthetic oligonucleotide 422ctgaagaagc tggagttgc
1942319DNAArtificial SequenceSynthetic oligonucleotide
423tccttgcagc aggcacatc 1942419DNAArtificial SequenceSynthetic
oligonucleotide 424tctgtgcgtg gactggaac 1942519DNAArtificial
SequenceSynthetic oligonucleotide 425ctttgctcgg aagacgttc
1942619DNAArtificial SequenceSynthetic oligonucleotide
426gaaggctttg gaaagtgtc 1942719DNAArtificial SequenceSynthetic
oligonucleotide 427gtgaactctg ctgcgactc 1942819DNAArtificial
SequenceSynthetic oligonucleotide 428gacaaggcta tgatgctgc
1942919DNAArtificial SequenceSynthetic oligonucleotide
429ggatgtgtgg tgctgtcac 1943019DNAArtificial SequenceSynthetic
oligonucleotide 430ctctgtgttc cacttcggc 1943119DNAArtificial
SequenceSynthetic oligonucleotide 431cagcaatgca gagtgtgac
1943219DNAArtificial SequenceSynthetic oligonucleotide
432caaagctggc tactactac 1943319DNAArtificial SequenceSynthetic
oligonucleotide 433cagtgcaaag agcccaaac 1943419DNAArtificial
SequenceSynthetic oligonucleotide 434gtattctgta caccctggc
1943519DNAArtificial SequenceSynthetic oligonucleotide
435gtgatcgaca ggattgctc 1943619DNAArtificial SequenceSynthetic
oligonucleotide 436cacagtgaaa ccttcctgc 1943719DNAArtificial
SequenceSynthetic oligonucleotide 437atctgtgaca ctggatcgc
1943819DNAArtificial SequenceSynthetic oligonucleotide
438agagactgga gttgtcagc 1943919DNAArtificial SequenceSynthetic
oligonucleotide 439cctgagttga atgtcatac 1944019DNAArtificial
SequenceSynthetic oligonucleotide 440ctgaactagt gactatccc
1944119DNAArtificial SequenceSynthetic oligonucleotide
441ataagcaccg tgagcgacc 1944219DNAArtificial SequenceSynthetic
oligonucleotide 442cattgggcca cagacctac 1944319DNAArtificial
SequenceSynthetic oligonucleotide 443gatgaagaca gcaaccaac
1944419DNAArtificial SequenceSynthetic oligonucleotide
444agcatatgat gaccttggc 1944519DNAArtificial SequenceSynthetic
oligonucleotide 445attccactac tacagctgc 1944619DNAArtificial
SequenceSynthetic oligonucleotide 446gaaactgtgg caggctaac
1944719DNAArtificial SequenceSynthetic oligonucleotide
447ctgatgaagg ccttcgacc 1944819DNAArtificial SequenceSynthetic
oligonucleotide 448ttgaaacaag aggaagtcc 1944919DNAArtificial
SequenceSynthetic oligonucleotide 449tgaacttgct ctgagctgc
1945019DNAArtificial SequenceSynthetic oligonucleotide
450atctgtaacc tcagcacac 1945119DNAArtificial SequenceSynthetic
oligonucleotide 451gaagctaagc ctcggttac 1945219DNAArtificial
SequenceSynthetic oligonucleotide 452taaccgtggc atctacctc
1945319DNAArtificial SequenceSynthetic oligonucleotide
453tgaccacctg gagtatcac 1945419DNAArtificial SequenceSynthetic
oligonucleotide 454gtggacatct ttgagcttc 1945519DNAArtificial
SequenceSynthetic oligonucleotide 455gctgagaagt acttccacc
1945619DNAArtificial SequenceSynthetic oligonucleotide
456agactactgc aagggcggc 1945719DNAArtificial SequenceSynthetic
oligonucleotide 457gagtatttgc tggcattcc 1945819DNAArtificial
SequenceSynthetic oligonucleotide 458ggagacacgg aataaactc
1945919DNAArtificial SequenceSynthetic oligonucleotide
459ccgagaccac ctcaatgtc 1946019DNAArtificial SequenceSynthetic
oligonucleotide 460atggacatct ccacgggac 1946119DNAArtificial
SequenceSynthetic oligonucleotide 461tatcctgacc ttcctgcgc
1946219DNAArtificial SequenceSynthetic oligonucleotide
462cacatgatca agctaggtc 1946319DNAArtificial SequenceSynthetic
oligonucleotide 463gaagccaggc atcttcatc 1946419DNAArtificial
SequenceSynthetic oligonucleotide 464gctgaagtta tccagtctc
1946519DNAArtificial SequenceSynthetic oligonucleotide
465agcattggac cagttgatc 1946619DNAArtificial SequenceSynthetic
oligonucleotide 466gtgatctacg tgaactggc 1946719DNAArtificial
SequenceSynthetic oligonucleotide 467gccgacagtg gtgcactac
1946819DNAArtificial SequenceSynthetic oligonucleotide
468aacatgatgg ctcagaacc 1946919DNAArtificial SequenceSynthetic
oligonucleotide 469tacagtgatg gatcatagc 1947019DNAArtificial
SequenceSynthetic oligonucleotide 470accaatatgc ctaccttcc
1947119DNAArtificial SequenceSynthetic oligonucleotide
471actgtatccc agcagtccc 1947219DNAArtificial SequenceSynthetic
oligonucleotide 472aagctgaaca taaccttgc 1947319DNAArtificial
SequenceSynthetic oligonucleotide 473ttgaatagct cggtgtccc
1947419DNAArtificial SequenceSynthetic oligonucleotide
474gtggaaggca agatcttcc 1947519DNAArtificial SequenceSynthetic
oligonucleotide 475tgtatggctg gtcgatcac 1947619DNAArtificial
SequenceSynthetic oligonucleotide 476gctgcgacaa cttctgttc
1947719DNAArtificial SequenceSynthetic oligonucleotide
477gcccacggtc ttccactac 1947819DNAArtificial SequenceSynthetic
oligonucleotide 478gactgaatca ggccttccc 194792196DNAhomo sapiens
479ccggcatttg cgtttggggc gccctccctg cgccgggggc gggagcccag
cgagcgcaga 60gccccggccc cgcgcggccc gagtgccaca tcactgcgct ggccgtccaa
ggtccgccgc 120cccaccatgc cgcccccgcc gccgctgctg ctccttacag
tcctggtcgt cgccgctgcc 180cggccggggt gcgagtttga gcggaacccc
gccgccacct gcgtggacct gcagctcagg 240acctgcagcg atgccgccta
caaccacacc accttcccca acctgcttca gcaccggtcg 300tgggaggtgg
tggaggccag ctccgagtac atcctgctga gcgttctaca ccagctcctg
360gaaggccagt gcaacccgga cctgcggctg ctgggctgtg ctgtgctggc
cccccggtgt 420gagggcggct gggtgcgcag accctgccgg cacatctgcg
agggcctgcg ggaggtctgc 480cagcccgcct tcgacgccat tgacatggcc
tggccctact tccttgactg ccaccgctac 540ttcacgagag aggacgaggg
ctgctatgac ccgctggaga agcttcgggg aggcctggag 600gctgacgagg
cactgccctc agggctgccg cccaccttca tccgcttcag ccaccactcc
660tacgcccaga tggtgcgtgt gctgaggcgg acggcctccc gctgcgccca
cgtggccagg 720acctacagca tcgggcgcag cttcgacggc agggagctgc
tggtcatcga gttctccagc 780cgccccggcc agcacgagct gatggagccc
gaggtgaagc tcatcggcaa cattcatggc 840aacgaggtgg cgggccggga
gatgctcatc tacctagccc agtacctgtg ctctgagtac 900ctgcttggta
acccccgcat ccagcgcctg ctcaacacca
cccgcatcca cctgctgccc 960tccatgaacc ctgacggcta tgaggtggca
gctgccgagg gtgccggcta caacgggtgg 1020acgagcggga ggcagaacgc
gcagaacctg gatctgaacc gaaatttccc ggacctgacg 1080tccgagtact
accggctggc ggagacccgc ggcgcacgca gcgaccacat ccccatcccc
1140cagcactact ggtggggtaa ggtggccccg gagacaaagg caatcatgaa
gtggatgcag 1200accataccct ttgtgctctc agccagcctt catgggggcg
acctggtggt gtcctacccc 1260ttcgacttct ccaagcaccc ccaggaggag
aagatgtttt ctcccacgcc cgacgagaag 1320atgttcaagc tgctgtccag
agcctacgct gacgtccacc ccatgatgat ggacaggtcg 1380gagaataggt
gtggaggcaa tttcctgaag agggggagca tcatcaacgg ggcggactgg
1440tacagcttca cgggaggcat gtccgatttc aactacctgc acaccaactg
ctttgagatc 1500acggtagagc tgggctgtgt gaagttcccc cccgaggagg
ccctgtacac actctggcag 1560cacaacaagg agtcactcct gaatttcgtg
gagacggtgc accggggcat caaaggtgtg 1620gtgacagata aattcggcaa
gccagtcaaa aacgcccgga tctcagtcaa aggcattcgc 1680cacgacatca
ccacagcccc agatggtgac tactggagac tgctgccccc aggtatccac
1740attgtcattg cccaagcccc tggctacgcc aaagtcatca agaaagtcat
catccccgcc 1800cggatgaaga gggctggccg tgtggacttc attctgcaac
ctctggggat gggacccaag 1860aactttattc atgggctgcg gaggactggg
ccccacgacc cgctgggagg tgccagctct 1920ttgggggagg ccacggagcc
cgacccgctc cgggcgcgca ggcagccctc ggccgacggg 1980agtaagccct
ggtggtggtc ctacttcaca tcgctgagca cccacaggcc acgctggctg
2040ctcaagtact agccccggcc ccagcacccg ccaggatgtg gagaccgagg
cccatctccg 2100catcccgggc tcctggctct tgattttgtc tgccacagac
atcccacaaa gccgctgcca 2160ttttattaaa gtgttttgat ccactttcca ctggaa
2196480641PRThomo sapiens 480Met Pro Pro Pro Pro Pro Leu Leu Leu
Leu Thr Val Leu Val Val Ala 1 5 10 15 Ala Ala Arg Pro Gly Cys Glu
Phe Glu Arg Asn Pro Ala Ala Thr Cys 20 25 30 Val Asp Leu Gln Leu
Arg Thr Cys Ser Asp Ala Ala Tyr Asn His Thr 35 40 45 Thr Phe Pro
Asn Leu Leu Gln His Arg Ser Trp Glu Val Val Glu Ala 50 55 60 Ser
Ser Glu Tyr Ile Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly 65 70
75 80 Gln Cys Asn Pro Asp Leu Arg Leu Leu Gly Cys Ala Val Leu Ala
Pro 85 90 95 Arg Cys Glu Gly Gly Trp Val Arg Arg Pro Cys Arg His
Ile Cys Glu 100 105 110 Gly Leu Arg Glu Val Cys Gln Pro Ala Phe Asp
Ala Ile Asp Met Ala 115 120 125 Trp Pro Tyr Phe Leu Asp Cys His Arg
Tyr Phe Thr Arg Glu Asp Glu 130 135 140 Gly Cys Tyr Asp Pro Leu Glu
Lys Leu Arg Gly Gly Leu Glu Ala Asp 145 150 155 160 Glu Ala Leu Pro
Ser Gly Leu Pro Pro Thr Phe Ile Arg Phe Ser His 165 170 175 His Ser
Tyr Ala Gln Met Val Arg Val Leu Arg Arg Thr Ala Ser Arg 180 185 190
Cys Ala His Val Ala Arg Thr Tyr Ser Ile Gly Arg Ser Phe Asp Gly 195
200 205 Arg Glu Leu Leu Val Ile Glu Phe Ser Ser Arg Pro Gly Gln His
Glu 210 215 220 Leu Met Glu Pro Glu Val Lys Leu Ile Gly Asn Ile His
Gly Asn Glu 225 230 235 240 Val Ala Gly Arg Glu Met Leu Ile Tyr Leu
Ala Gln Tyr Leu Cys Ser 245 250 255 Glu Tyr Leu Leu Gly Asn Pro Arg
Ile Gln Arg Leu Leu Asn Thr Thr 260 265 270 Arg Ile His Leu Leu Pro
Ser Met Asn Pro Asp Gly Tyr Glu Val Ala 275 280 285 Ala Ala Glu Gly
Ala Gly Tyr Asn Gly Trp Thr Ser Gly Arg Gln Asn 290 295 300 Ala Gln
Asn Leu Asp Leu Asn Arg Asn Phe Pro Asp Leu Thr Ser Glu 305 310 315
320 Tyr Tyr Arg Leu Ala Glu Thr Arg Gly Ala Arg Ser Asp His Ile Pro
325 330 335 Ile Pro Gln His Tyr Trp Trp Gly Lys Val Ala Pro Glu Thr
Lys Ala 340 345 350 Ile Met Lys Trp Met Gln Thr Ile Pro Phe Val Leu
Ser Ala Ser Leu 355 360 365 His Gly Gly Asp Leu Val Val Ser Tyr Pro
Phe Asp Phe Ser Lys His 370 375 380 Pro Gln Glu Glu Lys Met Phe Ser
Pro Thr Pro Asp Glu Lys Met Phe 385 390 395 400 Lys Leu Leu Ser Arg
Ala Tyr Ala Asp Val His Pro Met Met Met Asp 405 410 415 Arg Ser Glu
Asn Arg Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile 420 425 430 Ile
Asn Gly Ala Asp Trp Tyr Ser Phe Thr Gly Gly Met Ser Asp Phe 435 440
445 Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Val Glu Leu Gly Cys
450 455 460 Val Lys Phe Pro Pro Glu Glu Ala Leu Tyr Thr Leu Trp Gln
His Asn 465 470 475 480 Lys Glu Ser Leu Leu Asn Phe Val Glu Thr Val
His Arg Gly Ile Lys 485 490 495 Gly Val Val Thr Asp Lys Phe Gly Lys
Pro Val Lys Asn Ala Arg Ile 500 505 510 Ser Val Lys Gly Ile Arg His
Asp Ile Thr Thr Ala Pro Asp Gly Asp 515 520 525 Tyr Trp Arg Leu Leu
Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala 530 535 540 Pro Gly Tyr
Ala Lys Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met 545 550 555 560
Lys Arg Ala Gly Arg Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly 565
570 575 Pro Lys Asn Phe Ile His Gly Leu Arg Arg Thr Gly Pro His Asp
Pro 580 585 590 Leu Gly Gly Ala Ser Ser Leu Gly Glu Ala Thr Glu Pro
Asp Pro Leu 595 600 605 Arg Ala Arg Arg Gln Pro Ser Ala Asp Gly Ser
Lys Pro Trp Trp Trp 610 615 620 Ser Tyr Phe Thr Ser Leu Ser Thr His
Arg Pro Arg Trp Leu Leu Lys 625 630 635 640 Tyr
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.