U.S. patent application number 13/966797 was filed with the patent office on 2014-02-20 for cell penetrating peptides. This patent application is currently assigned to Medical Research Council. The applicant listed for this patent is Medical Research Council. Invention is credited to Andrey Alexandrovich Arzumanov, Michael John Gait, Gabriela Dimitroval Ivanova.
Application Number | 20140051646 13/966797 |
Document ID | / |
Family ID | 40977883 |
Filed Date | 2014-02-20 |
United States Patent Application | 20140051646 |
Kind Code | A1 |
Gait; Michael John ; et al. | February 20, 2014 |
The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Inventors: | Gait; Michael John; (Cambridge, GB) ; Arzumanov; Andrey Alexandrovich; (Cambridge, GB) ; Ivanova; Gabriela Dimitroval; (Cambridge, GB) | ||||||||||
Applicant: |
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Assignee: | Medical Research Council London GB |
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Family ID: | 40977883 | ||||||||||
Appl. No.: | 13/966797 | ||||||||||
Filed: | August 14, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12996307 | Dec 3, 2010 | 8575305 | ||
PCT/GB2009/001261 | May 15, 2009 | |||
13966797 | ||||
61058722 | Jun 4, 2008 | |||
Current U.S. Class: | 514/21.4 |
Current CPC Class: | A61P 25/28 20180101; A61K 31/7125 20130101; C07K 7/02 20130101; A61P 17/00 20180101; C07K 2319/10 20130101; A61P 35/00 20180101; A61K 47/64 20170801; A61P 21/04 20180101; C07K 14/001 20130101; A61P 25/16 20180101; A61P 7/06 20180101; A61P 9/00 20180101; A61P 25/14 20180101; A61P 21/00 20180101; A61P 3/00 20180101 |
Class at Publication: | 514/21.4 |
International Class: | A61K 47/48 20060101 A61K047/48; A61K 31/7125 20060101 A61K031/7125 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 304 <210> SEQ ID NO 1 <211> LENGTH: 25 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys-Lys-Lys <400>
SEQUENCE: 1 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln
Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 2 <211> LENGTH: 25 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Thioether linked to CH2-CO-Lys-PNA705-Lys-Lys-Lys <400>
SEQUENCE: 2 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln
Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 3 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 19 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 3 Arg
Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 1 5 10
15 Gly Gly Cys <210> SEQ ID NO 4 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys-Lys-Lys
<400> SEQUENCE: 4 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile
Trp Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20
<210> SEQ ID NO 5 <211> LENGTH: 28 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 28 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 5 Arg
Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Gln Ile Lys Ile Trp Phe 1 5 10
15 Gln Asn Arg Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 6 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 6 Arg
Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Leu Phe Gln Asn Arg 1 5 10
15 Xaa Arg Xaa Arg Xaa Arg Xaa Cys 20 <210> SEQ ID NO 7
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(11)..(11) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 7 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Cys 1 5 10 <210> SEQ ID
NO 8 <211> LENGTH: 14 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 14 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 8 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Cys 1 5 10 <210> SEQ
ID NO 9 <211> LENGTH: 26 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 26 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 9 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp Lys Lys Gly Gly Cys 20 25 <210> SEQ ID NO 10 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 24
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 10 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp Lys Lys Cys 20 <210> SEQ ID NO 11 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 11 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20 <210>
SEQ ID NO 12 <211> LENGTH: 24 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 12 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 13 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 24
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 13 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 His Arg Met Lys
Trp Lys Lys Cys 20 <210> SEQ ID NO 14 <211> LENGTH: 24
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 24 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 14 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp Lys Lys Cys 20
<210> SEQ ID NO 15 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is homoArg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 15 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 16 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 24 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 16 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp Lys Ala Cys
20 <210> SEQ ID NO 17 <211> LENGTH: 25 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 17 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 18 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 24
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 18 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Arg Cys 20 <210> SEQ ID NO 19 <211> LENGTH: 24
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (4)..(4) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (6)..(6) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 24 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 19 Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp Lys Lys Cys 20
<210> SEQ ID NO 20 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2, 4, 6, 8 <223> OTHER INFORMATION:
bAla <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 24 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 20 Arg Ala Arg Ala Arg Ala
Arg Ala Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp Lys Lys Cys 20 <210> SEQ ID NO 21 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (11)..(11) <223> OTHER
INFORMATION: Xaa is D-Lys <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (24) <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 25 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 21 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 22
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 22 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 23 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 24 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 25 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 23 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Arg Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 24
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(11)..(11) <223> OTHER INFORMATION: Xaa is D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 24 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 25 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 18 <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 25 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 26 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 25 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Leu Tyr Ser Pro Leu Ser Phe 1 5 10 15 Gln
Xaa Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 26
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 26 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Ser Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 27 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (15) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 27 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met
Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 28 <211>
LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 8, 14
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 21 <223>
OTHER INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: 22 <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 28 Arg
Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr Xaa Arg Met 1 5 10
15 Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 29 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 29 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 30 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 2, 8 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 30 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 31 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 31 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 32 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 11 <223> OTHER
INFORMATION: Xaa is D-Lys <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 24 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Thioether linked to CH2-CO-Lys-PNADMD-Lys <400> SEQUENCE: 32
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5
10 15 Xaa Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID
NO 33 <211> LENGTH: 25 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 24 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(25)..(25) <223> OTHER INFORMATION: Thioether linked to
CH2-CO-Lys-PNADMD-Lys <400> SEQUENCE: 33 Arg Xaa Arg Arg Xaa
Arg Arg Xaa Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met
Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 34 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Domain 1-3 peptide sequence <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 34 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 35 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 35 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 36 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 36 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 37 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 37 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 38 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 38 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp His Lys 20 <210> SEQ ID NO 39 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 39 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile His Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 40 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 40 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Arg Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp
His Lys 20 <210> SEQ ID NO 41 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 41 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Arg Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 42 <211> LENGTH: 22 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 42 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 43 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 43 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 44 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 44 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Lys Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 45 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 45 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Lys Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 46 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 46 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Xaa Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His Lys
20 <210> SEQ ID NO 47 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 47 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Xaa Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 48 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 48 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg His Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 49 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 49 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
His Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 50 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 50 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Arg Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 51 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 51 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 52 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 52 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Leu Phe Gln Asn Arg Arg 1 5 10 15 Met Lys Trp His Lys
20 <210> SEQ ID NO 53 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 53 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Leu Phe Gln Asn Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 54 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 54 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Lys Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp
His Lys 20 <210> SEQ ID NO 55 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 55 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 56 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 56 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 57 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 57 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 58 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 58 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile His Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys
Trp His Lys 20 <210> SEQ ID NO 59 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 59 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile His Ile Leu
Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 60 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 60 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Arg Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp
His Lys 20 <210> SEQ ID NO 61 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 61 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Arg Ile Leu
Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 62 <211> LENGTH: 22 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 62 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 63 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 63 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 64 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 64 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Lys Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 65 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 65 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Lys Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 66 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 66 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Xaa Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His Lys
20 <210> SEQ ID NO 67 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 67 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Xaa Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 68 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 68 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg His Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 69 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 69 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
His Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 70 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 70 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Arg Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 71 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 71 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 72 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 72 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Arg 1 5 10 15 Met Lys Trp His Lys
20 <210> SEQ ID NO 73 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 73 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 74 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: 2, 5 <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 74 Arg Xaa Arg Arg Xaa Arg 1 5 <210>
SEQ ID NO 75 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 75 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg 1 5
<210> SEQ ID NO 76 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5, 8, 11) <223> OTHER INFORMATION:
Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or
Aib <400> SEQUENCE: 76 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg 1 5 10 <210> SEQ ID NO 77 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1 sequence <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 2, 5 <223> OTHER
INFORMATION: bAla <400> SEQUENCE: 77 Arg Ala Arg Arg Ala Arg
1 5 <210> SEQ ID NO 78 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2, 5, 8 <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 78 Arg Ala Arg Arg Ala Arg Arg Ala Arg 1 5
<210> SEQ ID NO 79 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2, 5, 8, 11 <223> OTHER INFORMATION:
bAla <400> SEQUENCE: 79 Arg Ala Arg Arg Ala Arg Arg Ala Arg
Arg Ala Arg 1 5 10 <210> SEQ ID NO 80 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1 sequence <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (2, 5) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (8)..(8) <223> OTHER INFORMATION:
Xaa is D-Arg <400> SEQUENCE: 80 Arg Xaa Arg Arg Xaa Arg Ile
Xaa 1 5 <210> SEQ ID NO 81 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1 sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 81 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg 1 5 <210>
SEQ ID NO 82 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 82 Arg Ala Arg Arg Xaa Arg Arg Ala Arg 1 5 <210>
SEQ ID NO 83 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <400> SEQUENCE: 83 Arg Arg Arg Arg Arg 1 5
<210> SEQ ID NO 84 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <400> SEQUENCE: 84 Arg Arg Arg Arg Arg Arg 1 5
<210> SEQ ID NO 85 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <400> SEQUENCE: 85 Arg Arg Arg Arg Arg Arg Arg 1 5
<210> SEQ ID NO 86 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 86 Ile Leu Phe Gln 1 <210> SEQ
ID NO 87 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 87 Ile Leu Phe Gln Asn 1 5 <210> SEQ ID
NO 88 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 88 Ile Leu Phe Gln Tyr 1 5 <210> SEQ ID
NO 89 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Generic domain 2 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa may be
present or absent. If present, Xaa is Ile. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Lys, D-Lys, His, or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (7)..(7)
<223> OTHER INFORMATION: Xaa is Asn or Tyr <400>
SEQUENCE: 89 Xaa Xaa Ile Leu Phe Gln Xaa 1 5 <210> SEQ ID NO
90 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 90 Ile Lys Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 91 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 91 Ile Lys Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 92 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 92 Ile Xaa Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 93 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 93 Ile Xaa Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 94 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 94 Ile His Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 95 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 95 Ile His Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 96 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 96 Ile Arg Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 97 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 97 Ile Arg Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 98 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 98 Ile Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 99 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 99 Ile Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 100 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 100 Lys Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 101 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 101 Lys Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 102 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 1 <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 102 Xaa Ile Leu Phe Gln Asn 1 5 <210>
SEQ ID NO 103 <211> LENGTH: 6 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 1 <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 103 Xaa Ile Leu Phe Gln Tyr 1 5 <210>
SEQ ID NO 104 <211> LENGTH: 6 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 104 His Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 105 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 105 His Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 106 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 106 Arg Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 107 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 107 Arg Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 108 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 108 Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 109 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 109 Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 110 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <400> SEQUENCE: 110 Arg Arg Met Lys Trp His Lys 1 5
<210> SEQ ID NO 111 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 111 Xaa Arg Met Lys Trp His Lys 1 5
<210> SEQ ID NO 112 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 112 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Xaa Arg Met Lys Trp
His Lys 20 25 <210> SEQ ID NO 113 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 113 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ ID NO 114
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: PNA cargo PNA705 <400>
SEQUENCE: 114 cctcttacct cagttaca 18 <210> SEQ ID NO 115
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: PNA cargo PNADMD <400>
SEQUENCE: 115 ggccaaacct cggcttacct 20 <210> SEQ ID NO 116
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K3
<400> SEQUENCE: 116 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys
Ile Trp Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly
Cys 20 25 <210> SEQ ID NO 117 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K3 <400> SEQUENCE:
117 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg
1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 118
<211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K3
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 5, 8 <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 118 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg
Gln Ile Lys Ile Trp Phe 1 5 10 15 Gln Asn Arg Arg Met Lys Trp Lys
Lys Gly Gly Cys 20 25 <210> SEQ ID NO 119 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K3 <400> SEQUENCE:
119 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Leu Phe Gln Asn Pro
1 5 10 15 Lys Lys Lys Arg Lys Val Gly Gly Cys 20 25 <210> SEQ
ID NO 120 <211> LENGTH: 24 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Disulfide conjugate of
CKPNA705K3 <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 120 Arg Arg Arg Arg Arg Arg Arg
Gln Ile Lys Ile Leu Phe Gln Asn Arg 1 5 10 15 Xaa Arg Xaa Arg Xaa
Arg Xaa Cys 20 <210> SEQ ID NO 121 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K <400> SEQUENCE:
121 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg
1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25 <210> SEQ
ID NO 122 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Disulfide conjugate of
CKPNA705K <400> SEQUENCE: 122 His His Phe Phe Arg Arg Arg Arg
Arg Arg Arg Arg Arg Phe Phe Cys 1 5 10 15 <210> SEQ ID NO 123
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K
<400> SEQUENCE: 123 His His His His His His Arg Arg Arg Arg
Arg Arg Arg Arg Arg Phe 1 5 10 15 Phe Cys <210> SEQ ID NO 124
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K
<400> SEQUENCE: 124 His His His His His His Phe Phe Arg Arg
Arg Arg Arg Arg Arg Arg 1 5 10 15 Arg Phe Phe Cys 20 <210>
SEQ ID NO 125 <211> LENGTH: 19 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Disulfide
conjugate of CKPNA705K <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (6)..(7) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 125 His His His His His Xaa
Xaa Arg Arg Arg Arg Arg Arg Arg Arg Arg 1 5 10 15 Phe Phe Cys
<210> SEQ ID NO 126 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Disulfide
conjugate of CKPNA705K <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (7)..(8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 126 His His His His His His
Xaa Xaa Phe Phe Arg Arg Arg Arg Arg Arg 1 5 10 15 Arg Arg Arg Phe
Phe Cys 20 <210> SEQ ID NO 127 <211> LENGTH: 20
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (4)..(4)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 127 His His His Xaa Arg Arg Arg Arg Arg Arg
Arg Arg Arg Phe Phe Xaa 1 5 10 15 His His His Cys 20 <210>
SEQ ID NO 128 <211> LENGTH: 18 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: PNA705
<400> SEQUENCE: 128 cctcttacct cagttaca 18 <210> SEQ ID
NO 129 <211> LENGTH: 22 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Primer <400> SEQUENCE:
129 cagaattctg ccaattgctg ag 22 <210> SEQ ID NO 130
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Primer <400> SEQUENCE: 130
ttcttcagct tgtgtcatcc 20 <210> SEQ ID NO 131 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Primer <400> SEQUENCE: 131 cccagtctac
caccctatca gagc 24 <210> SEQ ID NO 132 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Primer <400> SEQUENCE: 132 cctgccttta aggcttcctt 20
<210> SEQ ID NO 133 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Primer
<400> SEQUENCE: 133 ttgatatgtg gatttcgagt cgtc 24 <210>
SEQ ID NO 134 <211> LENGTH: 23 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Primer
<400> SEQUENCE: 134 tgtcaatcag agtgcttttg gcg 23 <210>
SEQ ID NO 135 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 135 Ile Lys Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 136 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 136 Ile Lys Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 137 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 137 Ile Xaa Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 138 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 138 Ile Xaa Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 139 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 139 Ile His Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 140 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 140 Ile His Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 141 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 141 Ile Arg Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 142 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 142 Ile Arg Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 143 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 143 Ile Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 144 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 144 Ile Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 145 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 145 Lys Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 146 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 146 Lys Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 147 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
D-Lys <400> SEQUENCE: 147 Xaa Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 148 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
D-Lys <400> SEQUENCE: 148 Xaa Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 149 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 149 His Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 150 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 150 His Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 151 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 151 Arg Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 152 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 152 Arg Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 153 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 153 Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 154 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 154 Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 155 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 155 Xaa His Met Lys Trp His Lys 1 5
<210> SEQ ID NO 156 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 156 Xaa Arg Met Lys Trp His Lys 1 5
<210> SEQ ID NO 157 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 157 Xaa Arg Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 158 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 158 Xaa His Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 159 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 6) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 159 Arg Xaa Arg Ala Arg Xaa Arg 1 5 <210> SEQ ID NO
160 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2, 4, 6) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 160 Arg Xaa Arg Xaa Arg Xaa Arg 1 5
<210> SEQ ID NO 161 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 161 Arg Xaa Arg Arg Xaa Arg 1 5 <210>
SEQ ID NO 162 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (6)..(6) <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 162 Arg Ala Arg Xaa Arg Ala Arg 1 5 <210> SEQ ID NO
163 <211> LENGTH: 6 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2, 6) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(4)..(4) <223> OTHER INFORMATION: bAla <400> SEQUENCE:
163 Arg Xaa Arg Ala Arg Xaa 1 5 <210> SEQ ID NO 164
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 164 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa His Met Lys Trp His Lys 20 25 <210> SEQ ID NO 165
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 165 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 166
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 166 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 167
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21)..(21) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 167 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 168 <211> LENGTH:
26 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 168 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Xaa Arg Xaa Arg 20 25 <210> SEQ ID NO 169 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 169 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Arg Xaa Arg 20 25 <210> SEQ ID NO 170 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 170 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 171 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 171 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 172 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 172 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Ala Arg Xaa 20 25 <210> SEQ ID NO 173 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 173 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ ID NO 174
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 174 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa His Met Lys Trp His Lys 20 25 <210> SEQ ID NO 175
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 175 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 176
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 176 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 177
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 177 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 178 <211> LENGTH:
26 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 178 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg
Xaa Arg Xaa Arg 20 25 <210> SEQ ID NO 179 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 179 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 180 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 180 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 181 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 181 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 182 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 182 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 183 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 183 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa His Met Lys Trp His Lys 20 25 <210> SEQ ID NO 184
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 184 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 185
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 185 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 186
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 186 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Ala Arg
Xaa Arg 20 25 <210> SEQ ID NO 187 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 187 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Xaa Arg
Xaa Arg 20 25 <210> SEQ ID NO 188 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 188 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 189 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <400>
SEQUENCE: 189 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Ala Arg Xaa Arg Ala Arg 20 25
<210> SEQ ID NO 190 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21, 25) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (23)..(23) <223> OTHER
INFORMATION: bAla <400> SEQUENCE: 190 Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg
Xaa Arg Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 191 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 191 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 192 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 192 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ ID NO 193
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 193 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa His Met Lys Trp His Lys 20 25 <210> SEQ ID NO 194
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 194 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 195
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 195 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 196
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 196 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa Arg 20 25 <210> SEQ ID NO 197 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 197 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Xaa Arg
Xaa Arg 20 25 <210> SEQ ID NO 198 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 198 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 199 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21)..(21) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 199 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 200 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 200 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa Arg 20 25 <210> SEQ ID NO 201 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 201 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 202 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 202 Ile Leu Ile
Gln 1 <210> SEQ ID NO 203 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <400> SEQUENCE: 203 Met Lys Trp His Lys 1 5
<210> SEQ ID NO 204 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <400> SEQUENCE: 204 Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 205 <400> SEQUENCE: 205 000 <210>
SEQ ID NO 206 <211> LENGTH: 25 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: PMODMD
<400> SEQUENCE: 206 ggccaaacct cggcttacct gaaat 25
<210> SEQ ID NO 207 <211> LENGTH: 14 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: B peptide
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 8, 13 <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (5, 11, 14) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 207 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Xaa Ala 1 5 10 <210> SEQ ID NO 208 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 8) <223>
OTHER INFORMATION: Xaa is aminohexyl <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 15 <223>
OTHER INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 208 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys Ala Cys 20 <210>
SEQ ID NO 209 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5, 22 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 15 <223> OTHER INFORMATION: Xaa is D-Lys
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 209 Arg Xaa Arg Arg Ala
Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp
His Lys Ala Cys 20 <210> SEQ ID NO 210 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 210 Arg Xaa Arg Arg Ala
Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Trp Lys Trp
His Lys Ala Cys 20 <210> SEQ ID NO 211 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8,
11) <223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 13
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 211 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Cys 1 5 10 <210> SEQ ID NO 212
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Pip peptide conjugated to PNADMD
cargo <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 212 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 213 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 213 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 214 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 214 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 215 <211>
LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18) <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 25 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 26 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 215 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Leu Tyr Ser Pro Leu Ser Phe 1 5 10 15 Gln Xaa Arg Met
Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 216 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (22) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 216 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 217 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 8, 14
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 21 <223>
OTHER INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: 22 <223> OTHER INFORMATION:
Thioether linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 217 Arg
Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr Xaa Arg Met 1 5 10
15 Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 218 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2, 8, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 15
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 218 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 219 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15) <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 219 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 220 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
22 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 15
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 220 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 221 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 221 Arg Xaa Arg
Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met
Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 222 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 222 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa His 1 5 10 15 Met Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 223 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 223 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 224 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 224 Arg Xaa Arg
Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Trp
Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 225 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 225 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa His 1 5 10 15 Trp Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 226 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 2, 8, 16,
20 <223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 18,
22 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 226 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg Ala Cys 20
<210> SEQ ID NO 227 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 2, 8, 16, 18, 20 <223>
OTHER INFORMATION: Xaa is aminohexyl <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 227 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg Ala Cys 20
<210> SEQ ID NO 228 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 228 Arg Xaa Arg
Arg Ala Arg Arg Xaa Arg Ile Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met
Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 229 <211>
LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 5, 13, 16 <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 18 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 229 Arg Xaa Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa Arg Arg Xaa 1 5 10 15 Arg
Cys <210> SEQ ID NO 230 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Pip
peptide conjugated to PMODMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 18, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 230 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 231 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 231 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 232 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to PMODMD
<400> SEQUENCE: 232 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 233 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PMODMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (13)..(13) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (16)..(16) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 20 <223> OTHER
INFORMATION: Thioether linked to PMODMD <400> SEQUENCE: 233
Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa Arg Arg Xaa 1 5
10 15 Arg Cys Tyr Ser 20 <210> SEQ ID NO 234 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PMODMD cargo
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2, 8, 16, 20, 22 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 234 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala
Arg Ala Cys 20 <210> SEQ ID NO 235 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
18, 22 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 235 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 236 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 236 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg
Ala Cys 20 <210> SEQ ID NO 237 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
18, 21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 237 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Ala Cys 20 <210> SEQ ID NO 238 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 21
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 238 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg
Ala Cys 20 <210> SEQ ID NO 239 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 18,
21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 239 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Ala Cys 20 <210> SEQ ID NO 240 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 25
<223> OTHER INFORMATION: Thioether linked to PMODMD
<400> SEQUENCE: 240 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 241 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 11,
14 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 15 <223> OTHER INFORMATION: Thioether linked to
PMODMD <400> SEQUENCE: 241 Arg Xaa Arg Arg Ala Arg Arg Xaa
Arg Arg Ala Arg Xaa Ala Cys 1 5 10 15 <210> SEQ ID NO 242
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 242 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
243 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Lys <400>
SEQUENCE: 243 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
244 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 244 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg 1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO
245 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 245 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
246 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 18 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 246 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20
<210> SEQ ID NO 247 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 247 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 248 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 248 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 249 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 16, 20 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 249 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20
<210> SEQ ID NO 250 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 250 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20
<210> SEQ ID NO 251 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 251 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 252 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 252 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 253 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 253 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Trp Lys Trp His Lys 20
<210> SEQ ID NO 254 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 254 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 255 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 255 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg
20 <210> SEQ ID NO 256 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 256 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 257 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 257 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 258 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 16, 20 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 258 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20
<210> SEQ ID NO 259 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 259 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20
<210> SEQ ID NO 260 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 260 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
261 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <400> SEQUENCE:
261 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 262
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
262 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO 263
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
263 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 264
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 264 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20 <210> SEQ ID NO
265 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 265 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 266 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 266 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 267 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16, 20
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (18)..(18)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 267 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20 <210> SEQ ID NO
268 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 268 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20 <210> SEQ ID NO 269
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
269 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa His
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 270
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <400> SEQUENCE:
270 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 271
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
271 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa Arg
1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO 272
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
272 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 273
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 273 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20 <210> SEQ ID NO
274 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 274 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 275 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 275 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 276 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16, 20
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (18)..(18)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 276 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20 <210> SEQ ID NO
277 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 277 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20 <210> SEQ ID NO 278
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 278 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 279
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 279 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 280
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 280 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg Trp Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 281
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 281 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 282
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 282 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 283 <211> LENGTH: 18 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 283 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Xaa Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 284 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 284 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Arg Xaa 1 5 10 15 Arg <210> SEQ
ID NO 285 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 13, 17 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 285 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Arg Ala Arg Xaa Arg 1 5 10 15 Ala Arg <210> SEQ ID NO 286
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 286 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa <210> SEQ
ID NO 287 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 287 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa His Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 288
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 288 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 289
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 289 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Trp Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 290
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 290 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 291
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 291 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 292 <211> LENGTH: 18 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 292 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Xaa Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 293 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 293 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Arg Xaa 1 5 10 15 Arg <210> SEQ
ID NO 294 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 13, 17 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 294 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Arg Ala Arg Xaa Arg 1 5 10 15 Ala Arg <210> SEQ ID NO 295
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 295 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa <210> SEQ
ID NO 296 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 296 Ile Leu Ile Gln Tyr 1 5 <210> SEQ
ID NO 297 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Generic domain 2 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa may be
present or absent. If present, Xaa is Ile. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Lys, D-Lys, His, or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (7)..(7)
<223> OTHER INFORMATION: Xaa is Asn or Tyr <400>
SEQUENCE: 297 Xaa Xaa Ile Leu Ile Gln Xaa 1 5 <210> SEQ ID NO
298 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1) <223> OTHER INFORMATION: Xaa is Arg, D-Arg, Lys
or D-Lys <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2) <223> OTHER INFORMATION: Xaa is
Arg, His, or Lys <400> SEQUENCE: 298 Xaa Xaa Met Lys Trp His
Lys 1 5 <210> SEQ ID NO 299 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
Arg, D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (2) <223> OTHER INFORMATION:
Xaa is Arg, His, or Lys <400> SEQUENCE: 299 Xaa Xaa Trp Lys
Trp His Lys 1 5 <210> SEQ ID NO 300 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: THR-87, a 17-mer cyclic peptide <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (4)..(14)
<223> OTHER INFORMATION: D-Val D-Ala D-Leu D-Lys D-Leu D-Cys
D-Leu D-Lys D-Leu D-Ala D-Leu <400> SEQUENCE: 300 Pro Arg Pro
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Arg 1 5 10 15 Gly
<210> SEQ ID NO 301 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <400> SEQUENCE: 301 Arg Arg Arg Arg Arg Arg Arg Arg
1 5 <210> SEQ ID NO 302 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <400> SEQUENCE: 302 Arg Arg Met Lys Trp Lys Lys 1
5 <210> SEQ ID NO 303 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: SV40 <400> SEQUENCE: 303 Pro Lys
Lys Lys Arg Lys Val 1 5 <210> SEQ ID NO 304 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Domain 2 sequence <400> SEQUENCE: 304 Ile
Leu Ile Gln Asn 1 5
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 304
<210> SEQ ID NO 1 <211> LENGTH: 25 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys-Lys-Lys <400>
SEQUENCE: 1 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln
Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 2 <211> LENGTH: 25 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Thioether linked to CH2-CO-Lys-PNA705-Lys-Lys-Lys <400>
SEQUENCE: 2 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln
Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 3 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 19 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 3 Arg
Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 1 5 10
15 Gly Gly Cys <210> SEQ ID NO 4 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys-Lys-Lys
<400> SEQUENCE: 4 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile
Trp Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20
<210> SEQ ID NO 5 <211> LENGTH: 28 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 28 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 5 Arg
Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Gln Ile Lys Ile Trp Phe 1 5 10
15 Gln Asn Arg Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25
<210> SEQ ID NO 6 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys-Lys-Lys <400> SEQUENCE: 6 Arg
Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Leu Phe Gln Asn Arg 1 5 10
15 Xaa Arg Xaa Arg Xaa Arg Xaa Cys 20 <210> SEQ ID NO 7
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(11)..(11) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 7 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Cys 1 5 10 <210> SEQ ID
NO 8 <211> LENGTH: 14 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 14 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 8 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Cys 1 5 10 <210> SEQ
ID NO 9 <211> LENGTH: 26 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 26
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 9 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp Lys Lys Gly Gly Cys 20 25 <210> SEQ ID NO 10 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 24
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 10 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp Lys Lys Cys 20 <210> SEQ ID NO 11 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 11 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20 <210>
SEQ ID NO 12 <211> LENGTH: 24 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 12 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 13 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 24
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 13 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 His Arg Met Lys
Trp Lys Lys Cys 20 <210> SEQ ID NO 14 <211> LENGTH: 24
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 24 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 14 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp Lys Lys Cys 20
<210> SEQ ID NO 15 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is homoArg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 15 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa
Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 16 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 24 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 16 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Lys Ile Leu Phe Gln Asn 1 5 10 15
Xaa Arg Met Lys Trp Lys Ala Cys 20 <210> SEQ ID NO 17
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 17 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 18 <211> LENGTH: 24
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 24 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 18 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Arg Cys 20
<210> SEQ ID NO 19 <211> LENGTH: 24 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (6)..(6) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 24 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 19 Arg Xaa Arg
Xaa Arg Xaa Arg Xaa Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg
Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 20 <211>
LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 2, 4, 6, 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 24 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 20 Arg Ala Arg Ala Arg Ala Arg Ala Arg Ile
Lys Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp Lys Lys Cys
20 <210> SEQ ID NO 21 <211> LENGTH: 25 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (24) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 21 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 22 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 22 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 23 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 24 <223> OTHER
INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 23 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Arg Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 24 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (11)..(11) <223> OTHER
INFORMATION: Xaa is D-Lys <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 24 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 25 <223> OTHER INFORMATION: Disulfide
linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 24 Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa
Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 25
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 18
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 25 <223>
OTHER INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: 26 <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 25 Arg
Xaa Arg Arg Xaa Arg Arg Xaa Arg Leu Tyr Ser Pro Leu Ser Phe 1 5 10
15 Gln Xaa Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID
NO 26 <211> LENGTH: 25 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 24 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 25
<223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 26 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Ser Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 27 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (15)
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 22 <223>
OTHER INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: 23 <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 27 Arg
Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10
15 Met Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 28
<211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Peptide conjugate <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 8, 14
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 21 <223>
OTHER INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: 22 <223> OTHER INFORMATION:
Disulfide linked to Cys-Lys-PNA705-Lys <400> SEQUENCE: 28 Arg
Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr Xaa Arg Met 1 5 10
15 Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 29 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 29 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 30 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 2, 8 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 30 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 31 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 25 <223>
OTHER INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys
<400> SEQUENCE: 31 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 32 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 11 <223> OTHER
INFORMATION: Xaa is D-Lys <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (17)..(17) <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 24 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (25)..(25) <223> OTHER INFORMATION:
Thioether linked to CH2-CO-Lys-PNADMD-Lys <400> SEQUENCE: 32
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5
10 15 Xaa Arg Met Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID
NO 33 <211> LENGTH: 25 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Peptide conjugate
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 24 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(25)..(25) <223> OTHER INFORMATION: Thioether linked to
CH2-CO-Lys-PNADMD-Lys <400> SEQUENCE: 33 Arg Xaa Arg Arg Xaa
Arg Arg Xaa Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met
Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 34 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Domain 1-3 peptide sequence <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 34 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 35 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 35 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Lys Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 36 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 36 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 37 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11)
<223> OTHER INFORMATION: Xaa is D-Lys <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (17)..(17)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
37 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn
1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210> SEQ ID NO 38
<211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 38 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 39 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 39 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 40 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 40 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Arg Ile Leu Phe Gln Asn 1 5 10 15 Arg Arg Met Lys
Trp His Lys 20 <210> SEQ ID NO 41 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 41 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Arg Ile Leu
Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 42 <211> LENGTH: 22 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 42 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 43 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 43 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 44 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 44 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Lys Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 45 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 45 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Lys Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 46 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 46 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Xaa Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His Lys
20 <210> SEQ ID NO 47 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 47 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Xaa Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys
20
<210> SEQ ID NO 48 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 48 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg His Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 49 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 49 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
His Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 50 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 50 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Arg Ile Leu Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 51 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 51 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Ile Leu Phe Gln Asn Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 52 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 52 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Leu Phe Gln Asn Arg Arg 1 5 10 15 Met Lys Trp His Lys
20 <210> SEQ ID NO 53 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 53 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Leu Phe Gln Asn Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 54 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 54 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Lys Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp
His Lys 20 <210> SEQ ID NO 55 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 55 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Lys Ile Leu
Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 56 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 56 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 57 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 57 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 58 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl
<400> SEQUENCE: 58 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 59 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 59 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Ile His Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 60 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 60 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Arg Ile Leu Phe Gln Tyr 1 5 10 15 Arg Arg Met Lys
Trp His Lys 20 <210> SEQ ID NO 61 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 61 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile Arg Ile Leu
Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys Trp His Lys 20 <210>
SEQ ID NO 62 <211> LENGTH: 22 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 62 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 63 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 63 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 64 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 64 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Lys Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 65 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 65 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Lys Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 66 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 66 Arg Xaa Arg Arg Xaa Arg Arg Xaa
Arg Xaa Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His Lys
20 <210> SEQ ID NO 67 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 67 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Xaa Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 68 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 68 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg His Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 69 <211> LENGTH: 22 <212>
TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 69 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
His Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 70 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 70 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Arg Ile Leu Phe Gln Tyr Arg 1 5 10 15 Arg Met Lys Trp His
Lys 20 <210> SEQ ID NO 71 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 16 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 71 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Ile Leu Phe Gln Tyr Xaa 1 5 10 15 Arg Met Lys Trp His Lys 20
<210> SEQ ID NO 72 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 72 Arg Xaa Arg Arg Xaa Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Arg 1 5 10 15 Met Lys Trp His Lys
20 <210> SEQ ID NO 73 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 73 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 74 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: 2, 5 <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 74 Arg Xaa Arg Arg Xaa Arg 1 5 <210>
SEQ ID NO 75 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa
is aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 75 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg 1 5
<210> SEQ ID NO 76 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5, 8, 11) <223> OTHER INFORMATION:
Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or
Aib <400> SEQUENCE: 76 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg 1 5 10 <210> SEQ ID NO 77 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1 sequence <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 2, 5 <223> OTHER
INFORMATION: bAla <400> SEQUENCE: 77 Arg Ala Arg Arg Ala Arg
1 5 <210> SEQ ID NO 78 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2, 5, 8 <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 78 Arg Ala Arg Arg Ala Arg Arg Ala Arg 1 5
<210> SEQ ID NO 79 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2, 5, 8, 11 <223> OTHER INFORMATION:
bAla <400> SEQUENCE: 79 Arg Ala Arg Arg Ala Arg Arg Ala Arg
Arg Ala Arg 1 5 10 <210> SEQ ID NO 80 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1 sequence <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (2, 5) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (8)..(8) <223> OTHER INFORMATION:
Xaa is D-Arg <400> SEQUENCE: 80 Arg Xaa Arg Arg Xaa Arg Ile
Xaa 1 5 <210> SEQ ID NO 81 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5
<223> OTHER INFORMATION: bAla <400> SEQUENCE: 81 Arg
Xaa Arg Arg Ala Arg Arg Xaa Arg 1 5 <210> SEQ ID NO 82
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1 sequence <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (2, 8)
<223> OTHER INFORMATION: bAla <400> SEQUENCE: 82 Arg
Ala Arg Arg Xaa Arg Arg Ala Arg 1 5 <210> SEQ ID NO 83
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1 sequence <400>
SEQUENCE: 83 Arg Arg Arg Arg Arg 1 5 <210> SEQ ID NO 84
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1 sequence <400>
SEQUENCE: 84 Arg Arg Arg Arg Arg Arg 1 5 <210> SEQ ID NO 85
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1 sequence <400>
SEQUENCE: 85 Arg Arg Arg Arg Arg Arg Arg 1 5 <210> SEQ ID NO
86 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 86 Ile Leu Phe Gln 1 <210> SEQ ID NO 87
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 2 sequence <400>
SEQUENCE: 87 Ile Leu Phe Gln Asn 1 5 <210> SEQ ID NO 88
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 2 sequence <400>
SEQUENCE: 88 Ile Leu Phe Gln Tyr 1 5 <210> SEQ ID NO 89
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Generic domain 2 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa may be
present or absent. If present, Xaa is Ile. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Lys, D-Lys, His, or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (7)..(7)
<223> OTHER INFORMATION: Xaa is Asn or Tyr <400>
SEQUENCE: 89 Xaa Xaa Ile Leu Phe Gln Xaa 1 5 <210> SEQ ID NO
90 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 90 Ile Lys Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 91 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 91 Ile Lys Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 92 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 92 Ile Xaa Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 93 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 93 Ile Xaa Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 94 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 94 Ile His Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 95 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 95 Ile His Ile Leu Phe Gln Tyr 1 5
<210> SEQ ID NO 96 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 96 Ile Arg Ile Leu Phe Gln Asn 1 5
<210> SEQ ID NO 97 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 97 Ile Arg Ile
Leu Phe Gln Tyr 1 5 <210> SEQ ID NO 98 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 98 Ile Ile Leu
Phe Gln Asn 1 5 <210> SEQ ID NO 99 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 99 Ile Ile Leu
Phe Gln Tyr 1 5 <210> SEQ ID NO 100 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 100 Lys Ile Leu
Phe Gln Asn 1 5 <210> SEQ ID NO 101 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 101 Lys Ile Leu
Phe Gln Tyr 1 5 <210> SEQ ID NO 102 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 1 <223> OTHER
INFORMATION: Xaa is D-Lys <400> SEQUENCE: 102 Xaa Ile Leu Phe
Gln Asn 1 5 <210> SEQ ID NO 103 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 1 <223> OTHER
INFORMATION: Xaa is D-Lys <400> SEQUENCE: 103 Xaa Ile Leu Phe
Gln Tyr 1 5 <210> SEQ ID NO 104 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 104 His Ile Leu
Phe Gln Asn 1 5 <210> SEQ ID NO 105 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 105 His Ile Leu
Phe Gln Tyr 1 5 <210> SEQ ID NO 106 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 106 Arg Ile Leu
Phe Gln Asn 1 5 <210> SEQ ID NO 107 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 107 Arg Ile Leu
Phe Gln Tyr 1 5 <210> SEQ ID NO 108 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 108 Ile Leu Phe
Gln Asn 1 5 <210> SEQ ID NO 109 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 109 Ile Leu Phe
Gln Tyr 1 5 <210> SEQ ID NO 110 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 3 sequence <400> SEQUENCE: 110 Arg Arg Met
Lys Trp His Lys 1 5 <210> SEQ ID NO 111 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 3 sequence <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa is D-Arg <400> SEQUENCE: 111 Xaa Arg Met Lys
Trp His Lys 1 5 <210> SEQ ID NO 112 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 4 is absent
and Xaa5 - 12 is Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg
(SEQ ID NO: 80) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa -
Arg (SEQ ID NO: 81) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 3
is absent and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg
- Ala - Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 112 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Xaa Arg Met Lys Trp
His Lys 20 25 <210> SEQ ID NO 113 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 113 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ ID NO 114
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: PNA cargo PNA705 <400>
SEQUENCE: 114 cctcttacct cagttaca 18 <210> SEQ ID NO 115
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: PNA cargo PNADMD <400>
SEQUENCE: 115 ggccaaacct cggcttacct 20 <210> SEQ ID NO 116
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K3
<400> SEQUENCE: 116 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys
Ile Trp Phe Gln Asn Arg 1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly
Cys 20 25 <210> SEQ ID NO 117 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K3 <400> SEQUENCE:
117 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg
1 5 10 15 Arg Met Lys Trp Lys Lys Cys 20 <210> SEQ ID NO 118
<211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K3
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 5, 8 <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 118 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg
Gln Ile Lys Ile Trp Phe 1 5 10 15 Gln Asn Arg Arg Met Lys Trp Lys
Lys Gly Gly Cys 20 25 <210> SEQ ID NO 119 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K3 <400> SEQUENCE:
119 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Leu Phe Gln Asn Pro
1 5 10 15 Lys Lys Lys Arg Lys Val Gly Gly Cys 20 25 <210> SEQ
ID NO 120
<211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K3
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (21)..(21) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 120 Arg Arg Arg Arg Arg Arg Arg
Gln Ile Lys Ile Leu Phe Gln Asn Arg 1 5 10 15 Xaa Arg Xaa Arg Xaa
Arg Xaa Cys 20 <210> SEQ ID NO 121 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K <400> SEQUENCE:
121 Arg Arg Arg Arg Arg Arg Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg
1 5 10 15 Arg Met Lys Trp Lys Lys Gly Gly Cys 20 25 <210> SEQ
ID NO 122 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Disulfide conjugate of
CKPNA705K <400> SEQUENCE: 122 His His Phe Phe Arg Arg Arg Arg
Arg Arg Arg Arg Arg Phe Phe Cys 1 5 10 15 <210> SEQ ID NO 123
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K
<400> SEQUENCE: 123 His His His His His His Arg Arg Arg Arg
Arg Arg Arg Arg Arg Phe 1 5 10 15 Phe Cys <210> SEQ ID NO 124
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Disulfide conjugate of CKPNA705K
<400> SEQUENCE: 124 His His His His His His Phe Phe Arg Arg
Arg Arg Arg Arg Arg Arg 1 5 10 15 Arg Phe Phe Cys 20 <210>
SEQ ID NO 125 <211> LENGTH: 19 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Disulfide
conjugate of CKPNA705K <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (6)..(7) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 125 His His His His His Xaa
Xaa Arg Arg Arg Arg Arg Arg Arg Arg Arg 1 5 10 15 Phe Phe Cys
<210> SEQ ID NO 126 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Disulfide
conjugate of CKPNA705K <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (7)..(8) <223> OTHER INFORMATION:
Xaa is aminohexyl <400> SEQUENCE: 126 His His His His His His
Xaa Xaa Phe Phe Arg Arg Arg Arg Arg Arg 1 5 10 15 Arg Arg Arg Phe
Phe Cys 20 <210> SEQ ID NO 127 <211> LENGTH: 20
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Disulfide conjugate of CKPNA705K <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (4)..(4)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 127 His His His Xaa Arg Arg Arg Arg Arg Arg
Arg Arg Arg Phe Phe Xaa 1 5 10 15 His His His Cys 20 <210>
SEQ ID NO 128 <211> LENGTH: 18 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: PNA705
<400> SEQUENCE: 128 cctcttacct cagttaca 18 <210> SEQ ID
NO 129 <211> LENGTH: 22 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Primer <400> SEQUENCE:
129 cagaattctg ccaattgctg ag 22 <210> SEQ ID NO 130
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Primer <400> SEQUENCE: 130
ttcttcagct tgtgtcatcc 20 <210> SEQ ID NO 131 <211>
LENGTH: 24 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Primer <400> SEQUENCE: 131 cccagtctac
caccctatca gagc 24 <210> SEQ ID NO 132 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Primer <400> SEQUENCE: 132 cctgccttta aggcttcctt 20
<210> SEQ ID NO 133 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Primer
<400> SEQUENCE: 133 ttgatatgtg gatttcgagt cgtc 24 <210>
SEQ ID NO 134 <211> LENGTH: 23 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Primer
<400> SEQUENCE: 134 tgtcaatcag agtgcttttg gcg 23 <210>
SEQ ID NO 135 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 135 Ile Lys Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 136 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 136 Ile Lys Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 137 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 137 Ile Xaa Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 138 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 138 Ile Xaa Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 139 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 139 Ile His Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 140 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 140 Ile His Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 141 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 141 Ile Arg Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 142 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 142 Ile Arg Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 143 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 143 Ile Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 144 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 144 Ile Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 145 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 145 Lys Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 146 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 146 Lys Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 147 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
D-Lys <400> SEQUENCE: 147 Xaa Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 148 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
D-Lys <400> SEQUENCE: 148 Xaa Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 149 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 149 His Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 150 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 150 His Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 151 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 151 Arg Ile Leu Ile Gln Asn 1 5
<210> SEQ ID NO 152 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence <400> SEQUENCE: 152 Arg Ile Leu Ile Gln Tyr 1 5
<210> SEQ ID NO 153 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 2
sequence
<400> SEQUENCE: 153 Ile Leu Ile Gln Asn 1 5 <210> SEQ
ID NO 154 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 2 sequence
<400> SEQUENCE: 154 Ile Leu Ile Gln Tyr 1 5 <210> SEQ
ID NO 155 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 155 Xaa His Met Lys Trp His Lys 1 5
<210> SEQ ID NO 156 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 156 Xaa Arg Met Lys Trp His Lys 1 5
<210> SEQ ID NO 157 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Arg <400> SEQUENCE: 157 Xaa Arg Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 158 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa
is D-Lys <400> SEQUENCE: 158 Xaa His Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 159 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 6) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 159 Arg Xaa Arg Ala Arg Xaa Arg 1 5 <210> SEQ ID NO
160 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2, 4, 6) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 160 Arg Xaa Arg Xaa Arg Xaa Arg 1 5
<210> SEQ ID NO 161 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2, 5) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 161 Arg Xaa Arg Arg Xaa Arg 1 5 <210>
SEQ ID NO 162 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (6)..(6) <223> OTHER INFORMATION: bAla <400>
SEQUENCE: 162 Arg Ala Arg Xaa Arg Ala Arg 1 5 <210> SEQ ID NO
163 <211> LENGTH: 6 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (2, 6) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION:
(4)..(4) <223> OTHER INFORMATION: bAla <400> SEQUENCE:
163 Arg Xaa Arg Ala Arg Xaa 1 5 <210> SEQ ID NO 164
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 164 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Xaa His Met Lys Trp
His Lys 20 25 <210> SEQ ID NO 165 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 165 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 166
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 166 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu
1 5 10 15 Phe Gln Xaa Xaa His Trp Lys Trp His Lys 20 25 <210>
SEQ ID NO 167 <211> LENGTH: 26 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21)..(21) <223>
OTHER INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (23)..(23) <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (25)..(25) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (26)..(26) <223> OTHER
INFORMATION: Attached to Z6 linker <400> SEQUENCE: 167 Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10
15 Phe Gln Xaa Arg Xaa Arg Ala Arg Xaa Arg 20 25 <210> SEQ ID
NO 168 <211> LENGTH: 26 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21, 23, 25) <223>
OTHER INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (26)..(26) <223> OTHER
INFORMATION: Attached to Z6 linker <400> SEQUENCE: 168 Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10
15 Phe Gln Xaa Arg Xaa Arg Xaa Arg Xaa Arg 20 25 <210> SEQ ID
NO 169 <211> LENGTH: 25 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa
7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 169 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Arg Xaa Arg 20 25 <210> SEQ ID NO 170 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 170 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 171 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21, 25) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (23)..(23) <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 171 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Arg Xaa Arg Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 172
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 172 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg
Ala Arg Xaa 20 25 <210> SEQ ID NO 173 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 173
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5
10 15 Ile Gln Xaa Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ
ID NO 174 <211> LENGTH: 26 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 174 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Xaa His Met Lys Trp
His Lys 20 25 <210> SEQ ID NO 175 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 175 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 176
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 4 is absent
and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is absent and
Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7
- 12 is (Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12
is (Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION:
Attached to Z6 linker <400> SEQUENCE: 176 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 177
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 177 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 178 <211> LENGTH:
26 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (14)..(14)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Lys, D-Lys, His, or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (19)..(19)
<223> OTHER INFORMATION: Xaa is Asn or Tyr <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION: (21,
23, 25) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 178 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Xaa Arg
Xaa Arg 20 25 <210> SEQ ID NO 179 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 179 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 180 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 180 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 181 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (26)..(26) <223> OTHER INFORMATION: Attached to Z6
linker <400> SEQUENCE: 181 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg
Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 182 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Attached to Z6 linker
<400> SEQUENCE: 182 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 183 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 -
12 is (Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 183 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa His Met Lys Trp His Lys 20 25 <210> SEQ ID NO 184
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 184 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa
Xaa Arg Trp Lys Trp His Lys 20 25 <210> SEQ ID NO 185
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 185 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15
Phe Gln Xaa Xaa His Trp Lys Trp His Lys 20 25 <210> SEQ ID NO
186 <211> LENGTH: 26 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21, 25) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (23)..(23) <223> OTHER
INFORMATION: bAla <400> SEQUENCE: 186 Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg
Xaa Arg Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 187 <211>
LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 187 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Xaa Arg
Xaa Arg 20 25 <210> SEQ ID NO 188 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and
Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6
- 12 is (Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12
is (Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 188 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 189 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib <400>
SEQUENCE: 189 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Ala Arg Xaa Arg Ala Arg 20 25
<210> SEQ ID NO 190 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 190 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Ala Arg
Xaa Arg 20 25 <210> SEQ ID NO 191 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 191 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Phe Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 192 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is Arg or
D-Arg, Lys or D-Lys <400> SEQUENCE: 192 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa
Xaa Arg Met Lys Trp His Lys 20 25 <210> SEQ ID NO 193
<211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <400>
SEQUENCE: 193 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Xaa His Met Lys Trp His Lys 20 25
<210> SEQ ID NO 194 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present, Xaa is
Lys, D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (20)..(20) <223>
OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys <400>
SEQUENCE: 194 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Xaa Arg Trp Lys Trp His Lys 20 25
<210> SEQ ID NO 195 <211> LENGTH: 26 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Xaa - Arg)4 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa 4-12 is (Arg - Xaa - Arg)3 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 6
is absent and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In
an embodiment, Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3
wherein Ala is bAla. In an embodiment, Xaa1 - 6 is absent and
Xaa7-12 is (Arg - Ala - Arg)2 wherein Ala is bAla. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 - 4
is absent and Xaa5 - 12 is (Arg)8. In an embodiment, Xaa1 - 5 is
absent and Xaa6 - 12 is (Arg)7. In an embodiment, Xaa1 - 6 is
absent and Xaa7 - 12 is (Arg)6. In an embodiment, Xaa1 - 7 is
absent and Xaa8 - 12 is (Arg)5. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
Arg - Xaa - Arg - Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is
Arg - Xaa - Arg - Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81)
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 3 is absent
and Xaa4 - 12 is Arg - Ala - Arg - Arg - Xaa - Arg - Arg - Ala -
Arg (SEQ ID NO: 82) wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib and Ala is bAla <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Ile. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (14)..(14) <223>
OTHER INFORMATION: Xaa may be present or absent. If present,
Xaa
is Lys, D-Lys, His, or Arg <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (19)..(19) <223>
OTHER INFORMATION: Xaa is Asn or Tyr <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is Arg or D-Arg, Lys or D-Lys
<400> SEQUENCE: 195 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Xaa His Trp Lys Trp
His Lys 20 25 <210> SEQ ID NO 196 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 196 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa Arg 20 25 <210> SEQ ID NO 197 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 23, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 197 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Xaa Arg
Xaa Arg 20 25 <210> SEQ ID NO 198 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 24) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<400> SEQUENCE: 198 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Arg Xaa
Arg 20 25 <210> SEQ ID NO 199 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (21)..(21) <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 199 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Ala Arg Xaa Arg
Ala Arg 20 25 <210> SEQ ID NO 200 <211> LENGTH: 26
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4 wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa 4-12 is (Arg - Xaa - Arg)3
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 6 is absent and Xaa 7-12 is
(Arg - Xaa - Arg)2 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 12 is (Arg
- Ala - Arg)4 wherein Ala is bAla. In an embodiment, Xaa1 - 3 is
absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is bAla. In an
embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg - Ala - Arg)2
wherein Ala is bAla. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID
NO: 82) wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib and Ala is bAla <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (13)..(13)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Ile. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (14)..(14) <223> OTHER
INFORMATION: Xaa may be present or absent. If present, Xaa is Lys,
D-Lys, His, or Arg <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (19)..(19) <223> OTHER
INFORMATION: Xaa is Asn or Tyr <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (21, 25) <223> OTHER
INFORMATION: Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: (23)..(23) <223> OTHER
INFORMATION: bAla <400> SEQUENCE: 200 Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg
Xaa Arg Ala Arg Xaa Arg 20 25 <210> SEQ ID NO 201 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 12 is (Arg - Xaa - Arg)4
wherein Xaa is aminohexyl, beta-alanyl, p-aminobenzoyl,
isonipecotyl, or Aib. <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 3 is absent and Xaa 4-12 is
(Arg - Xaa - Arg)3 wherein Xaa is aminohexyl, beta-alanyl,
p-aminobenzoyl, isonipecotyl, or Aib. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (1)..(12)
<223> OTHER INFORMATION: In an embodiment, Xaa1 - 6 is absent
and Xaa 7-12 is (Arg - Xaa - Arg)2 wherein Xaa is aminohexyl,
beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(1)..(12) <223> OTHER INFORMATION: In an embodiment, Xaa1 -
12 is (Arg - Ala - Arg)4 wherein Ala is bAla. In an embodiment,
Xaa1 - 3 is absent and Xaa4-12 is (Arg - Ala - Arg)3 wherein Ala is
bAla. In an embodiment, Xaa1 - 6 is absent and Xaa7-12 is (Arg -
Ala - Arg)2 wherein Ala is bAla. <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (1)..(12) <223> OTHER
INFORMATION: In an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is
(Arg)8. In an embodiment, Xaa1 - 5 is absent and Xaa6 - 12 is
(Arg)7. In an embodiment, Xaa1 - 6 is absent and Xaa7 - 12 is
(Arg)6. In an embodiment, Xaa1 - 7 is absent and Xaa8 - 12 is
(Arg)5. <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 4 is absent and Xaa5 - 12 is Arg - Xaa - Arg
- Arg - Xaa - Arg - Ile - D-Arg (SEQ ID NO: 80) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib.
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(12) <223> OTHER INFORMATION: In an
embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Xaa - Arg -
Arg - Ala - Arg - Arg - Xaa - Arg (SEQ ID NO: 81) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1)..(12) <223> OTHER INFORMATION: In
an embodiment, Xaa1 - 3 is absent and Xaa4 - 12 is Arg - Ala - Arg
- Arg - Xaa - Arg - Arg - Ala - Arg (SEQ ID NO: 82) wherein Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib and
Ala is bAla <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
may be present or absent. If present, Xaa is Ile. <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(14)..(14) <223> OTHER INFORMATION: Xaa may be present or
absent. If present, Xaa is Lys, D-Lys, His, or Arg <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(19)..(19) <223> OTHER INFORMATION: Xaa is Asn or Tyr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (21, 25) <223> OTHER INFORMATION: Xaa is
aminohexyl, beta-alanyl, p-aminobenzoyl, isonipecotyl, or Aib
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (23)..(23) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 201 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Ile Leu 1 5 10 15 Ile Gln Xaa Arg Xaa Arg Ala Arg
Xaa 20 25 <210> SEQ ID NO 202 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 2 sequence <400> SEQUENCE: 202 Ile Leu Ile
Gln 1 <210> SEQ ID NO 203 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <400> SEQUENCE: 203 Met Lys Trp His Lys 1 5
<210> SEQ ID NO 204 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 3
sequence <400> SEQUENCE: 204 Trp Lys Trp His Lys 1 5
<210> SEQ ID NO 205 <400> SEQUENCE: 205 000 <210>
SEQ ID NO 206 <211> LENGTH: 25 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: PMODMD
<400> SEQUENCE: 206 ggccaaacct cggcttacct gaaat 25
<210> SEQ ID NO 207 <211> LENGTH: 14 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: B peptide
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 8, 13 <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (5, 11, 14) <223> OTHER INFORMATION: bAla
<400> SEQUENCE: 207 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Xaa Ala 1 5 10 <210> SEQ ID NO 208 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Peptide conjugate <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2, 8) <223>
OTHER INFORMATION: Xaa is aminohexyl <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 15 <223>
OTHER INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 23 <223> OTHER
INFORMATION: Disulfide linked to Cys-Lys-PNA705-Lys <400>
SEQUENCE: 208 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys Ala Cys
20 <210> SEQ ID NO 209 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Peptide
conjugate <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5, 22 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 15 <223> OTHER INFORMATION: Xaa is D-Lys
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 209 Arg Xaa Arg Arg Ala
Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp
His Lys Ala Cys 20 <210> SEQ ID NO 210 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Peptide conjugate <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Disulfide linked to
Cys-Lys-PNA705-Lys <400> SEQUENCE: 210 Arg Xaa Arg Arg Ala
Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Trp Lys Trp
His Lys Ala Cys 20 <210> SEQ ID NO 211 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 5, 8,
11) <223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 13
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 211 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Arg Xaa Arg Cys 1 5 10 <210> SEQ ID NO 212
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Pip peptide conjugated to PNADMD
cargo <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 212 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 213 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 213 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 214 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa
is D-Lys <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 24 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 25 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 214 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr 1 5 10 15 Xaa Arg Met Lys
Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 215 <211>
LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18) <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 25 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 26 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 215 Arg Xaa Arg Arg Xaa Arg
Arg Xaa Arg Leu Tyr Ser Pro Leu Ser Phe 1 5 10 15 Gln Xaa Arg Met
Lys Trp His Lys Ala Cys 20 25 <210> SEQ ID NO 216 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 5, 8) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 15 <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE:
<221> NAME/KEY: MOD_RES <222> LOCATION: (22)
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 216 Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 217 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 8, 14 <223> OTHER
INFORMATION: Xaa is D-Arg <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 21 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 217 Arg Xaa Arg
Arg Xaa Arg Ile Xaa Ile Leu Phe Gln Tyr Xaa Arg Met 1 5 10 15 Lys
Trp His Lys Ala Cys 20 <210> SEQ ID NO 218 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2, 8, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 15
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 218 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 219 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15) <223> OTHER INFORMATION: Xaa is
D-Arg <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 219 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 220 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
22 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 15
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 220 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 221 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2, 8) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is D-Arg <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 221 Arg Xaa Arg
Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Met
Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 222 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 222 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa His 1 5 10 15 Met Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 223 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 223 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Xaa Arg 1 5 10 15
Met Lys Trp His Lys Ala Cys 20 <210> SEQ ID NO 224
<211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Pip peptide conjugated to PNADMD
cargo <220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2, 8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 224 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg 1 5 10 15 Trp Lys Trp His
Lys Ala Cys 20 <210> SEQ ID NO 225 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 225 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Xaa His 1 5 10 15 Trp Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 226 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 2, 8, 16, 20 <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 18, 22 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to CH2-CO-K-PNADMD-K <400> SEQUENCE: 226 Arg Xaa Arg
Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg
Ala Arg Xaa Arg Ala Cys 20 <210> SEQ ID NO 227 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PNADMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 2, 8, 16, 18, 20 <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5, 22 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 23 <223> OTHER INFORMATION: Thioether linked to
CH2-CO-K-PNADMD-K <400> SEQUENCE: 227 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 228 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PNADMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2, 8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: 23 <223>
OTHER INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K
<400> SEQUENCE: 228 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 229 <211> LENGTH: 18 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PNADMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 2, 5, 13, 16 <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 18 <223> OTHER
INFORMATION: Thioether linked to CH2-CO-K-PNADMD-K <400>
SEQUENCE: 229 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa
Arg Arg Xaa 1 5 10 15 Arg Cys <210> SEQ ID NO 230 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PMODMD cargo
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5, 18, 22 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 230 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 231 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 231 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 232 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 22
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 23
<223> OTHER INFORMATION: Thioether linked to PMODMD
<400> SEQUENCE: 232 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys Ala Cys 20
<210> SEQ ID NO 233 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PMODMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (13)..(13) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (16)..(16) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: 20 <223> OTHER
INFORMATION: Thioether linked to PMODMD <400> SEQUENCE: 233
Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa Arg Arg Xaa 1 5
10 15 Arg Cys Tyr Ser 20 <210> SEQ ID NO 234 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Pip peptide conjugated to PMODMD cargo
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2, 8, 16, 20, 22 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 234 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala
Arg Ala Cys 20 <210> SEQ ID NO 235 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
18, 22 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 23 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 235 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Arg Ala Cys 20 <210> SEQ ID NO 236 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 236 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg
Ala Cys 20 <210> SEQ ID NO 237 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 2, 8,
18, 21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 237 Arg Ala Arg Arg Xaa Arg
Arg Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Ala Cys 20
<210> SEQ ID NO 238 <211> LENGTH: 22 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Pip peptide
conjugated to PMODMD cargo <220> FEATURE: <221>
NAME/KEY: SITE <222> LOCATION: (2)..(2) <223> OTHER
INFORMATION: Xaa is aminohexyl <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: 5, 21 <223> OTHER
INFORMATION: bAla <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 238 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg
Ala Cys 20 <210> SEQ ID NO 239 <211> LENGTH: 22
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 18,
21 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: 22 <223> OTHER INFORMATION: Thioether
linked to PMODMD <400> SEQUENCE: 239 Arg Xaa Arg Arg Ala Arg
Arg Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa
Ala Cys 20 <210> SEQ ID NO 240 <211> LENGTH: 25
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 24
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is D-Arg <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: 25
<223> OTHER INFORMATION: Thioether linked to PMODMD
<400> SEQUENCE: 240 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
His Ile Leu Phe Gln Asn 1 5 10 15 Xaa Arg Met Lys Trp His Lys Ala
Cys 20 25 <210> SEQ ID NO 241 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Pip peptide conjugated to PMODMD cargo <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 5, 11,
14 <223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: 15 <223> OTHER INFORMATION: Thioether linked to
PMODMD <400> SEQUENCE: 241 Arg Xaa Arg Arg Ala Arg Arg Xaa
Arg Arg Ala Arg Xaa Ala Cys 1 5 10 15 <210> SEQ ID NO 242
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 242 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
243 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Lys <400>
SEQUENCE: 243 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
244 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 244 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg
1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO 245
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 245 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
246 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 5 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 18 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(20)..(20) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 246 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20
<210> SEQ ID NO 247 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 247 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 248 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 248 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 249 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 16, 20 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 249 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20
<210> SEQ ID NO 250 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 250 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20
<210> SEQ ID NO 251 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 251 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 252 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 252 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 253 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 253 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Trp Lys Trp His Lys 20
<210> SEQ ID NO 254 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 254 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20
<210> SEQ ID NO 255 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 255 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg
20 <210> SEQ ID NO 256 <211> LENGTH: 21 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 256 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 257 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
SITE <222> LOCATION: (2)..(2) <223> OTHER INFORMATION:
Xaa is aminohexyl <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 257 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 258 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 16, 20 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 258 Arg Xaa Arg Arg Ala Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20
<210> SEQ ID NO 259 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 5 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 18 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 259 Arg Xaa Arg Arg Ala Arg Arg
Xaa Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20
<210> SEQ ID NO 260 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 260 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Xaa His 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
261 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <400> SEQUENCE:
261 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 262
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
262 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO 263
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
263 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 264
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 264 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20 <210> SEQ ID NO
265 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (18)..(18) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 265 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 266 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 266 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Phe Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 267 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16, 20
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (18)..(18)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 267 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20 <210> SEQ ID NO
268 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 268 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Phe Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20 <210> SEQ ID NO 269
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
269 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa His
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 270
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Lys <400> SEQUENCE:
270 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa Arg
1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO 271
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
271 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln Tyr Xaa Arg
1 5 10 15 Trp Lys Trp His Lys 20 <210> SEQ ID NO 272
<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is D-Arg <400>
SEQUENCE: 272 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Xaa Arg 1 5 10 15 Met Lys Trp His Lys 20 <210> SEQ ID NO
273 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 273 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa Arg 20 <210> SEQ ID NO
274 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(18)..(18) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (20)..(20) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 274 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Xaa Arg Xaa Arg
20 <210> SEQ ID NO 275 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
1-3 peptide sequence <220> FEATURE: <221> NAME/KEY:
MOD_RES <222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(16)..(16) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (19)..(19) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 275 Arg Ala Arg Arg Xaa Arg Arg
Ala Arg Ile Leu Ile Gln Tyr Arg Xaa 1 5 10 15 Arg Arg Xaa Arg 20
<210> SEQ ID NO 276 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 2 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 8 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 16, 20
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (18)..(18)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 276 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Ala 1 5 10 15 Arg Xaa Arg Ala Arg 20 <210> SEQ ID NO
277 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 2 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 8
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (16)..(16)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: 18
<223> OTHER INFORMATION: bAla <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (20)..(20)
<223> OTHER INFORMATION: Xaa is aminohexyl <400>
SEQUENCE: 277 Arg Ala Arg Arg Xaa Arg Arg Ala Arg Ile Leu Ile Gln
Tyr Arg Xaa 1 5 10 15 Arg Ala Arg Xaa 20 <210> SEQ ID NO 278
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 278 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Xaa His Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 279
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (12)
<223> OTHER INFORMATION: Xaa is D-Lys <400> SEQUENCE:
279 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg Met Lys Trp
1 5 10 15 His Lys <210> SEQ ID NO 280 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (12)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
280 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg Trp Lys Trp
1 5 10 15 His Lys <210> SEQ ID NO 281 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (12)
<223> OTHER INFORMATION: Xaa is D-Arg <400> SEQUENCE:
281 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln Tyr Xaa Arg Met Lys Trp
1 5 10 15 His Lys <210> SEQ ID NO 282 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 15 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 282 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa Arg <210> SEQ ID NO 283
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 283 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Xaa Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 284 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 284 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Arg Xaa 1 5 10 15 Arg <210> SEQ
ID NO 285 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 13, 17 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 285 Arg Xaa Arg Arg Xaa Arg Ile Leu Phe Gln
Tyr Arg Ala Arg Xaa Arg 1 5 10 15 Ala Arg <210> SEQ ID NO 286
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 286 Arg Xaa Arg Arg Xaa Arg Ile
Leu Phe Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa
<210> SEQ ID NO 287 <211> LENGTH: 18 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (12) <223> OTHER INFORMATION: Xaa is
D-Arg <400> SEQUENCE: 287 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile
Gln Tyr Xaa His Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO
288 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Lys
<400> SEQUENCE: 288 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 289
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 289 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Trp Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 290
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (12) <223> OTHER INFORMATION: Xaa is D-Arg
<400> SEQUENCE: 290 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Xaa Arg Met Lys Trp 1 5 10 15 His Lys <210> SEQ ID NO 291
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is
aminohexyl <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: 15 <223> OTHER INFORMATION: bAla
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa is
aminohexyl <400> SEQUENCE: 291 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 292 <211> LENGTH: 18 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (15)..(15) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (17)..(17) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 292 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Xaa Arg 1 5 10 15 Xaa Arg <210>
SEQ ID NO 293 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1-3
peptide sequence <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa
is aminohexyl <220> FEATURE: <221> NAME/KEY: SITE
<222> LOCATION: (16)..(16) <223> OTHER INFORMATION: Xaa
is aminohexyl <400> SEQUENCE: 293 Arg Xaa Arg Arg Xaa Arg Ile
Leu Ile Gln Tyr Arg Xaa Arg Arg Xaa 1 5 10 15 Arg <210> SEQ
ID NO 294 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 1-3 peptide sequence
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: SITE <222>
LOCATION: (5)..(5) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 13, 17 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 294 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Arg Ala Arg Xaa Arg 1 5 10 15 Ala Arg <210> SEQ ID NO 295
<211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: Domain 1-3 peptide sequence <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION: (5)..(5)
<223> OTHER INFORMATION: Xaa is aminohexyl <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(13)..(13) <223> OTHER INFORMATION: Xaa is aminohexyl
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: 15 <223> OTHER INFORMATION: bAla <220>
FEATURE: <221> NAME/KEY: SITE <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is aminohexyl
<400> SEQUENCE: 295 Arg Xaa Arg Arg Xaa Arg Ile Leu Ile Gln
Tyr Arg Xaa Arg Ala Arg 1 5 10 15 Xaa <210> SEQ ID NO 296
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Domain 2 sequence <400>
SEQUENCE: 296 Ile Leu Ile Gln Tyr 1 5 <210> SEQ ID NO 297
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic sequence: Generic domain 2 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa may be
present or absent. If present, Xaa is Ile. <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be present or absent. If
present, Xaa is Lys, D-Lys, His, or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (7)..(7)
<223> OTHER INFORMATION: Xaa is Asn or Tyr <400>
SEQUENCE: 297 Xaa Xaa Ile Leu Ile Gln Xaa 1 5 <210> SEQ ID NO
298 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic sequence: Domain 3 sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1) <223> OTHER INFORMATION: Xaa is Arg, D-Arg, Lys
or D-Lys <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2) <223> OTHER INFORMATION: Xaa is
Arg, His, or Lys <400> SEQUENCE: 298 Xaa Xaa Met Lys Trp His
Lys 1 5 <210> SEQ ID NO 299 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (1) <223> OTHER INFORMATION: Xaa is
Arg, D-Arg, Lys or D-Lys <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (2) <223> OTHER INFORMATION:
Xaa is Arg, His, or Lys <400> SEQUENCE: 299 Xaa Xaa Trp Lys
Trp His Lys 1 5 <210> SEQ ID NO 300 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
sequence: THR-87, a 17-mer cyclic peptide <220> FEATURE:
<221> NAME/KEY: SITE <222> LOCATION: (4)..(14)
<223> OTHER INFORMATION: D-Val D-Ala D-Leu D-Lys D-Leu D-Cys
D-Leu D-Lys D-Leu D-Ala D-Leu <400> SEQUENCE: 300 Pro Arg Pro
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Arg 1 5 10 15 Gly
<210> SEQ ID NO 301 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic sequence: Domain 1
sequence <400> SEQUENCE: 301 Arg Arg Arg Arg Arg Arg Arg Arg
1 5 <210> SEQ ID NO 302 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic sequence: Domain
3 sequence <400> SEQUENCE: 302 Arg Arg Met Lys Trp Lys Lys 1
5 <210> SEQ ID NO 303 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: SV40 <400> SEQUENCE: 303 Pro Lys
Lys Lys Arg Lys Val 1 5 <210> SEQ ID NO 304 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic sequence: Domain 2 sequence <400> SEQUENCE: 304 Ile
Leu Ile Gln Asn 1 5
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