U.S. patent application number 13/836163 was filed with the patent office on 2014-01-09 for b-cell reduction using cd37-specific and cd20-specific binding molecules. The applicant listed for this patent is Emergent Product Development Seattle, LLC. Invention is credited to William Brady, Laura Sue Grosmaire, Martha Susan Hayden-Ledbetter, Jeffrey A. Ledbetter, Sandy Alexander Simon, Peter Armstrong Thompson.
Application Number | 20140010813 13/836163 |
Document ID | / |
Family ID | 37683960 |
Filed Date | 2014-01-09 |
United States Patent Application | 20140010813 |
Kind Code | A1 |
Grosmaire; Laura Sue ; et al. | January 9, 2014 |
The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
Inventors: | Grosmaire; Laura Sue; (Hobart, WA) ; Hayden-Ledbetter; Martha Susan; (Shoreline, WA) ; Ledbetter; Jeffrey A.; (Shoreline, WA) ; Thompson; Peter Armstrong; (Bellevue, WA) ; Simon; Sandy Alexander; (Seattle, WA) ; Brady; William; (Bothell, WA) | ||||||||||
Applicant: |
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Family ID: | 37683960 | ||||||||||
Appl. No.: | 13/836163 | ||||||||||
Filed: | March 15, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11493132 | Jul 25, 2006 | |||
13836163 | ||||
60800595 | May 16, 2006 | |||
60702499 | Jul 25, 2005 | |||
Current U.S. Class: | 424/135.1 ; 424/133.1; 424/174.1 |
Current CPC Class: | A61P 21/04 20180101; A61P 3/10 20180101; A61K 39/39558 20130101; A61K 2039/505 20130101; A61P 29/00 20180101; A61K 39/3955 20130101; A61P 25/00 20180101; A61P 35/02 20180101; A61P 37/00 20180101; C07K 2317/53 20130101; A61P 21/00 20180101; A61P 43/00 20180101; C07K 16/30 20130101; C07K 2317/56 20130101; C07K 16/2887 20130101; C07K 16/2896 20130101; C07K 2317/52 20130101; C07K 2317/734 20130101; A61P 35/00 20180101; C07K 2317/622 20130101; A61P 37/06 20180101; A61P 17/00 20180101; A61P 19/02 20180101; C07K 2317/24 20130101; C07K 2317/73 20130101; C07K 2317/72 20130101; C07K 2317/732 20130101; C07K 2317/75 20130101; A61K 2039/507 20130101; A61P 17/06 20180101; A61P 27/02 20180101; C07K 16/3061 20130101; A61K 45/06 20130101; C07K 2317/567 20130101; A61P 1/04 20180101; A61P 37/02 20180101; C07K 2317/565 20130101; C07K 2317/76 20130101; A61K 2039/545 20130101; A61K 39/39558 20130101; A61K 2300/00 20130101 |
Class at Publication: | 424/135.1 ; 424/174.1; 424/133.1 |
International Class: | C07K 16/30 20060101 C07K016/30 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 226 <210> SEQ ID NO 1 <211> LENGTH: 1510
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: TRU-016
polynucleotide <400> SEQUENCE: 1 aagcttgccg ccatggattt
tcaagtgcag attttcagct tcctgctaat cagtgcttca 60 gtcataattg
ccagaggagt cgacatccag atgactcagt ctccagcctc cctatctgca 120
tctgtgggag agactgtcac catcacatgt cgaacaagtg aaaatgttta cagttatttg
180 gcttggtatc agcagaaaca gggaaaatct cctcagctcc tggtctcttt
tgcaaaaacc 240 ttagcagaag gtgtgccatc aaggttcagt ggcagtggat
caggcacaca gttttctctg 300 aagatcagca gcctgcagcc tgaagattct
ggaagttatt tctgtcaaca tcattccgat 360 aatccgtgga cgttcggtgg
aggcaccgaa ctggagatca aaggtggcgg tggctcgggc 420 ggtggtgggt
cgggtggcgg cggatcgtca gcggtccagc tgcagcagtc tggacctgag 480
tcggaaaagc ctggcgcttc agtgaagatt tcctgcaagg cttctggtta ctcattcact
540 ggctacaata tgaactgggt gaagcagaat aatggaaaga gccttgagtg
gattggaaat 600 attgatcctt attatggtgg tactacctac aaccggaagt
tcaagggcaa ggccacattg 660 actgtagaca aatcctccag cacagcctac
atgcagctca agagtctgac atctgaggac 720 tctgcagtct attactgtgc
aagatcggtc ggccctatgg actactgggg tcaaggaacc 780 tcagtcaccg
tctcttcaga tctggagccc aaatcttctg acaaaactca cacatctcca 840
ccgtgcccag cacctgaact cttgggtgga ccgtcagtct tcctcttccc cccaaaaccc
900 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt
ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg
gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac
agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct
gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc
ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1200
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc
1260 ctggtcaaag gcttctatcc aagcgacatc gccgtggagt gggagagcaa
tgggcaaccg 1320 gagaacaact acaagaccac gcctcccgtg ctggactccg
acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg
cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa
ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1500 tgagtctaga 1510
<210> SEQ ID NO 2 <211> LENGTH: 496 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: TRU-016 peptide <400>
SEQUENCE: 2 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser
Ala Ser 1 5 10 15 Val Ile Ile Ala Arg Gly Val Asp Ile Gln Met Thr
Gln Ser Pro Ala 20 25 30 Ser Leu Ser Ala Ser Val Gly Glu Thr Val
Thr Ile Thr Cys Arg Thr 35 40 45 Ser Glu Asn Val Tyr Ser Tyr Leu
Ala Trp Tyr Gln Gln Lys Gln Gly 50 55 60 Lys Ser Pro Gln Leu Leu
Val Ser Phe Ala Lys Thr Leu Ala Glu Gly 65 70 75 80 Val Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 85 90 95 Lys Ile
Ser Ser Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe Cys Gln 100 105 110
His His Ser Asp Asn Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu 115
120 125 Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly 130 135 140 Ser Ser Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Ser
Glu Lys Pro 145 150 155 160 Gly Ala Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr 165 170 175 Gly Tyr Asn Met Asn Trp Val Lys
Gln Asn Asn Gly Lys Ser Leu Glu 180 185 190 Trp Ile Gly Asn Ile Asp
Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg 195 200 205 Lys Phe Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 210 215 220 Ala Tyr
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 225 230 235
240 Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr
245 250 255 Ser Val Thr Val Ser Ser Asp Leu Glu Pro Lys Ser Ser Asp
Lys Thr 260 265 270 His Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330 335 Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 340 345 350 Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 355 360
365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455 460 Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 465 470 475 480
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 495 <210> SEQ ID NO 3 <211> LENGTH: 1518
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: TRU-015
polynucleotide <400> SEQUENCE: 3 aagcttgccg ccatggattt
tcaagtgcag attttcagct tcctgctaat cagtgcttca 60 gtcataatgt
ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct 120
ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg
180 taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc
caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt gggtctggga
cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga tgctgccact
tattactgcc agcagtggag ttttaaccca 360 cccacgttcg gtgctgggac
caagctggag ctgaaagatg gcggtggctc gggcggtggt 420 ggatctggag
gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg 480
aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac
540 aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg
agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag aagttcaagg
gcaaggccac actgactgta 660 gacaaatcct ccagcacagc ctacatgcag
ctcagcagcc tgacatctga agactctgcg 720 gtctatttct gtgcaagagt
ggtgtactat agtaactctt actggtactt cgatgtctgg 780 ggcacaggga
ccacggtcac cgtctctgat caggagccca aatcttgtga caaaactcac 840
acatctccac cgtgctcagc acctgaactc ctgggtggac cgtcagtctt cctcttcccc
900 ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg
cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt
acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc gcgggaggag
cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg tcctgcacca
ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140 aacaaagccc
tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 1200
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc
1260 ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg
ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg cctcccgtgc
tggactccga cggctccttc 1380 ttcctctaca gcaagctcac cgtggacaag
agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga tgcatgaggc
tctgcacaac cactacacgc agaagagcct ctccctgtct 1500 ccgggtaaat
gatctaga 1518 <210> SEQ ID NO 4 <211> LENGTH: 499
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: TRU-015 peptide
<400> SEQUENCE: 4 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu
Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val
Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu
Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr
Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro
Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala
Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90
95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu
Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu
Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val
Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile
Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys
Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215
220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe
Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln
Glu Pro Lys Ser Cys 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Cys
Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340
345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465
470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser 485 490 495 Pro Gly Lys <210> SEQ ID NO 5 <211>
LENGTH: 1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 5 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 6 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 6 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 7 <211> LENGTH:
1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 7 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggagctctg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 8 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 8 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 9 <211> LENGTH:
1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 9 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagt cgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 10 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 10 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Ser Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 11 <211>
LENGTH: 1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 11 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtca aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 12 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 12 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 13 <211>
LENGTH: 1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 13 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aagtgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 14 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 14 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Ser 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 15 <211>
LENGTH: 1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 15 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gagcaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 16 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 16 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 17 <211>
LENGTH: 1479 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 17 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gacatccaga
tgactcagtc tccagcctcc ctatctgcat ctgtgggaga gactgtcacc 120
atcacatgtc gaacaagtga aaatgtttac agttatttgg cttggtatca gcagaaacag
180 ggaaaatctc ctcagctcct ggtctctttt gcaaaaacct tagcagaagg
tgtgccatca 240 aggttcagtg gcagtggatc aggcacacag ttttctctga
agatcagcag cctgcagcct 300 gaagattctg gaagttattt ctgtcaacat
cattccgata atccgtggac gttcggtgga 360 ggcaccgaac tggagatcaa
aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc 420 ggagctagcg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaggattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gcccagcacc tgaactcctg 840
ggtggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
900 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc
1260 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 1479 <210> SEQ ID NO 18 <211>
LENGTH: 492 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 18 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 20 25 30 Ala Ser
Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 50
55 60 Gln Leu Leu Val Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro
Ser 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu
Lys Ile Ser 85 90 95 Ser Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gly Gly
Thr Glu Leu Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Arg
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305
310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425
430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 19 <211> LENGTH:
1479 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 19 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtagtggatc tggaggaggt 420 ggagctagcg
cggtccagct gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480
gtgaagattt cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg
540 aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggcaag gccacattga
ctgtagacaa atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca
tctgaggact ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga
ctactggggt caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gcccagcacc tgaactcctg 840
ggtggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
900 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc
1260 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 1479 <210> SEQ ID NO 20 <211>
LENGTH: 492 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 20 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Ser
Gly Ser Gly Gly Gly Gly Ala Ser Ala 130 135 140 Val Gln Leu Gln Gln
Ser Gly Pro Glu Ser Glu Lys Pro Gly Ala Ser 145 150 155 160 Val Lys
Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr
Ala Tyr Met 210 215 220 Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Gln Gly Thr Ser Val Thr 245 250 255 Val Ser Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305
310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425
430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 21 <211> LENGTH:
1479 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 21 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcc
aggtgcagct ggtggagtct ggtggaggcg tggtccagcc tgggaggtcc 480
ctgagactct cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc
540 cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gcccagcacc tgaactcctg 840
ggtggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
900 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc
1260 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 1479 <210> SEQ ID NO 22 <211>
LENGTH: 492 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 22 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ala Ser Gln 130 135 140 Val Gln Leu Val Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 145 150 155 160 Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305
310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425
430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 23 <211> LENGTH:
1503 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 23 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gcggtccagc
tgcagcagtc tggacctgag tcggaaaagc ctggcgcttc agtgaagatt 120
tcctgcaagg cttctggtta ctcattcact ggctacaata tgaactgggt gaagcagaat
180 aatggaaaga gccttgagtg gattggaaat attgatcctt attatggtgg
tactacctac 240 aaccggaagt tcaagggcaa ggccacattg actgtagaca
aatcctccag cacagcctac 300 atgcagctca agagtctgac atctgaggac
tctgcagtct attactgtgc aagatcggtc 360 ggccctatgg actactgggg
tcaaggaacc tcagtcaccg tctcttctgg tggcggtggc 420 tcgggcggtg
gtgggtcggg tggcggcgga tcaggaggag gcgggagtgc tagcgaaatt 480
gtgttgacac agtctccagc caccctgtct ttgtctccag gcgaaagagc caccctctcc
540 tgccgaacaa gtgaaaatgt ttacagctac ttagcctggt accaacagaa
acctggccag 600 gctcctaggc tcctcatcta ttttgcaaaa accttagcag
aaggaattcc agccaggttc 660 agtggcagtg gatccgggac agacttcact
ctcaccatca gcagcctaga gcctgaagat 720 tttgcagttt attactgtca
acatcattcc gataatccgt ggacattcgg ccaagggacc 780 aaggtggaaa
tcaaaggctc gagcgagccc aaatcttctg acaaaactca cacatctcca 840
ccgtgcccag cacctgaact cctgggtgga ccgtcagtct tcctcttccc cccaaaaccc
900 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt
ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg
gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac
agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct
gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc
ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1200
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc
1260 ctggtcaaag gcttctatcc aagcgacatc gccgtggagt gggagagcaa
tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg ctggactccg
acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg
cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa
ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1500 tga 1503
<210> SEQ ID NO 24 <211> LENGTH: 500 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 24 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Ala Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu 20 25 30 Lys Pro Gly Ala Ser Val Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr Gly Tyr Asn Met Asn
Trp Val Lys Gln Asn Asn Gly Lys Ser 50 55 60 Leu Glu Trp Ile Gly
Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 65 70 75 80 Asn Arg Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Ser
Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 100 105
110 Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln
115 120 125 Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly 130 135 140 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Ser Glu Ile 145 150 155 160 Val Leu Thr Gln Ser Pro Ala Thr Leu
Ser Leu Ser Pro Gly Glu Arg 165 170 175 Ala Thr Leu Ser Cys Arg Thr
Ser Glu Asn Val Tyr Ser Tyr Leu Ala 180 185 190 Trp Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe 195 200 205 Ala Lys Thr
Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 210 215 220 Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 225 230
235 240 Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr
Phe 245 250 255 Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Ser Glu
Pro Lys Ser 260 265 270 Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 305 310 315 320 His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 325 330 335 Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 355
360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 465 470 475
480 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
485 490 495 Ser Pro Gly Lys 500 <210> SEQ ID NO 25
<211> LENGTH: 1488 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 25
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataattgcc
60 agaggagtcg aaattgtgtt gacacagtct ccagccaccc tgtctttgtc
tccaggcgaa 120 agagccaccc tctcctgccg aacaagtgaa aatgtttaca
gctacttagc ctggtaccaa 180 cagaaacctg gccaggctcc taggctcctc
atctattttg caaaaacctt agcagaagga 240 attccagcca ggttcagtgg
cagtggatcc gggacagact tcactctcac catcagcagc 300 ctagagcctg
aagattttgc agtttattac tgtcaacatc attccgataa tccgtggaca 360
ttcggccaag ggaccaaggt ggaaatcaaa ggtggcggtg gctcgggcgg tggtggatct
420 ggaggaggtg gagctagcgc ggtccagctg cagcagtctg gacctgagtc
ggaaaagcct 480 ggcgcttcag tgaagatttc ctgcaaggct tctggttact
cattcactgg ctacaatatg 540 aactgggtga agcagaataa tggaaagagc
cttgagtgga ttggaaatat tgatccttat 600 tatggtggta ctacctacaa
ccggaagttc aagggcaagg ccacattgac tgtagacaaa 660 tcctccagca
cagcctacat gcagctcaag agtctgacat ctgaggactc tgcagtctat 720
tactgtgcaa gatcggtcgg ccctatggac tactggggtc aaggaacctc agtcaccgtc
780 tcctcgagcg agcccaaatc ttctgacaaa actcacacat ctccaccgtg
cccagcacct 840 gaactcctgg gtggaccgtc agtcttcctc ttccccccaa
aacccaagga caccctcatg 900 atctcccgga cccctgaggt cacatgcgtg
gtggtggacg tgagccacga agaccctgag 960 gtcaagttca actggtacgt
ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 1020 gaggagcagt
acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1080
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc
1140 gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta
caccctgccc 1200 ccatcccggg atgagctgac caagaaccag gtcagcctga
cctgcctggt caaaggcttc 1260 tatccaagcg acatcgccgt ggagtgggag
agcaatgggc agccggagaa caactacaag 1320 accacgcctc ccgtgctgga
ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 1380 gacaagagca
ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1440
cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga 1488
<210> SEQ ID NO 26 <211> LENGTH: 495 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 26 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Ile Ala Arg Gly Val Glu Ile Val Leu
Thr Gln Ser Pro Ala 20 25 30 Thr Leu Ser Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Thr 35 40 45 Ser Glu Asn Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly 50 55 60 Gln Ala Pro Arg Leu
Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly 65 70 75 80 Ile Pro Ala
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 85 90 95 Thr
Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 100 105
110 His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
115 120 125 Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 130 135 140 Ala Ser Ala Val Gln Leu Gln Gln Ser Gly Pro Glu
Ser Glu Lys Pro 145 150 155 160 Gly Ala Ser Val Lys Ile Ser Cys Lys
Ala Ser Gly Tyr Ser Phe Thr 165 170 175 Gly Tyr Asn Met Asn Trp Val
Lys Gln Asn Asn Gly Lys Ser Leu Glu 180 185 190 Trp Ile Gly Asn Ile
Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg 195 200 205 Lys Phe Lys
Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 210 215 220 Ala
Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 225 230
235 240 Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly
Thr 245 250 255 Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His 260 265 270 Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val 275 280 285 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 290 295 300 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 305 310 315 320 Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 325 330 335 Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 340 345 350
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 355
360 365 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 370 375 380 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 385 390 395 400 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu 405 410 415 Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn 420 425 430 Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 435 440 445 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 450 455 460 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 465 470 475
480 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 495 <210> SEQ ID NO 27 <211> LENGTH: 1503
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 27 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gcggtccagc tgcagcagtc
tggacctgag tcggaaaagc ctggcgcttc agtgaagatt 120 tcctgcaagg
cttctggtta ctcattcact ggctacaata tgaactgggt gaagcagaat 180
aatggaaaga gccttgagtg gattggaaat attgatcctt attatggtgg tactacctac
240 aaccggaagt tcaagggcaa ggccacattg actgtagaca aatcctccag
cacagcctac 300 atgcagctca agagtctgac atctgaggac tctgcagtct
attactgtgc aagatcggtc 360 ggccctatgg actactgggg tcaaggaacc
tcagtcaccg tctcttctgg tggcggtggc 420 tcgggcggtg gtgggtcggg
tggcggcgga tcaggaggag gcgggagtgc tagcgaaatt 480 gtgttgacac
agtctccagc caccctgtct ttgtctccag gcgaaagagc caccctctcc 540
tgccgaacaa gtgaaaatgt ttacagctac ttagcctggt accaacagaa acctggccag
600 gctcctaggc tcctcatcta ttttgcaaaa accttagcag aaggaattcc
agccaggttc 660 agtggcagtg gatccgggac agacttcact ctcaccatca
gcagcctaga gcctgaagat 720 tttgcagttt attactgtca acatcattcc
gataatccgt ggacattcgg ccaagggacc 780 aaggtggaaa tcaaaggctc
gagcgagccc aaatcttctg acaaaactca cacatgccca 840 ccgtgcccag
cacctgaact cctgggtgga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aaccatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc aagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaaa 1500 tga 1503 <210> SEQ ID
NO 28 <211> LENGTH: 500 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 28 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu
20 25 30 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly
Tyr Ser 35 40 45 Phe Thr Gly Tyr Asn Met Asn Trp Val Lys Gln Asn
Asn Gly Lys Ser 50 55 60 Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Thr Tyr 65 70 75 80 Asn Arg Lys Phe Lys Gly Lys Ala
Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Ser Thr Ala Tyr Met Gln
Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 100 105 110 Val Tyr Tyr Cys
Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln 115 120 125 Gly Thr
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 130 135 140
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile 145
150 155 160 Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
Glu Arg 165 170 175 Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn Val Tyr
Ser Tyr Leu Ala 180 185 190 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Arg Leu Leu Ile Tyr Phe 195 200 205 Ala Lys Thr Leu Ala Glu Gly Ile
Pro Ala Arg Phe Ser Gly Ser Gly 210 215 220 Ser Gly Thr Asp Phe Thr
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 225 230 235 240 Phe Ala Val
Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe 245 250 255 Gly
Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Ser Glu Pro Lys Ser 260 265
270 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
275 280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser 305 310 315 320 His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu 325 330 335 Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350 Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 355 360 365 Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 370 375 380 Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 385 390
395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val 405 410 415 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val 465 470 475 480 Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 485 490 495 Ser Pro
Gly Lys 500 <210> SEQ ID NO 29 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 29 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcg cggtccagct
gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480 gtgaagattt
cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg 540
aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa
atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca tctgaggact
ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga ctactggggt
caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 30 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 30 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Ala 130 135 140 Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu Lys Pro Gly Ala Ser 145 150 155 160 Val Lys Ile
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr Met 210 215 220 Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 31 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 31 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcg cggtccagct
gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480 gtgaagattt
cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg 540
aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa
atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca tctgaggact
ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga ctactggggt
caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 32 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 32 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Ala 130 135 140 Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu Lys Pro Gly Ala Ser 145 150 155 160 Val Lys Ile
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr Met 210 215 220 Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 33 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 33 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcc aggtgcagct
ggtggagtct ggtggaggcg tggtccagcc tgggaggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 34 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 34 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Gln 130 135 140 Val Gln Leu Val Glu Ser
Gly Gly Gly Val Val Gln Pro Gly Arg Ser 145 150 155 160 Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 35 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 35 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcc aggtgcagct
ggtggagtct ggtggaggcg tggtccagcc tgggaggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 36 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 36 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Gln 130 135 140 Val Gln Leu Val Glu Ser
Gly Gly Gly Val Val Gln Pro Gly Arg Ser 145 150 155 160 Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 37 <211> LENGTH: 1476
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 37 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggggctagcg aggtgcagct
ggtggagtct ggtggaggct tggtccagcc tggagggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg ggtaaa
1476 <210> SEQ ID NO 38 <211> LENGTH: 492 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 38 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu
Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85
90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His
Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser 145 150 155 160 Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met Asn Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile
Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205
Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210
215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly
Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330
335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455
460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 39 <211> LENGTH: 1476 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 39 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggggctagcg aggtgcagct
ggtggagtct ggtggaggct tggtccagcc tggagggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg ggtaaa
1476 <210> SEQ ID NO 40 <211> LENGTH: 492 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 40 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu
Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85
90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His
Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser 145 150 155 160 Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met Asn Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile
Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205
Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210
215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly
Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330
335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455
460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 41 <211> LENGTH: 1476 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 41 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggggctagcg aggtgcagct
ggtggagtct ggtggaggct ctgtccagcc tggagggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg ggtaaa
1476 <210> SEQ ID NO 42 <211> LENGTH: 492 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 42 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu
Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85
90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His
Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Glu Ser Gly Gly Gly
Ser Val Gln Pro Gly Gly Ser 145 150 155 160 Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met Asn Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile
Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205
Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210
215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly
Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330
335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455
460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 43 <211> LENGTH: 1476 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 43 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggggctagcg aggtgcagct
ggtggagtct ggtggaggct ctgtccagcc tggagggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg ggtaaa
1476 <210> SEQ ID NO 44 <211> LENGTH: 492 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 44 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu
Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85
90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His
Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Glu Ser Gly Gly Gly
Ser Val Gln Pro Gly Gly Ser 145 150 155 160 Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met Asn Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile
Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205
Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210
215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly
Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330
335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455
460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 45 <211> LENGTH: 1482 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 45 atggaagccc cagctcagct tctcttcctc
ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gagcaagtca aagtgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg aggtgcagct
ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480 ctgaagattt
cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg 540
cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca aatcttctga
caaaactcac acatctccac cgtgcccagc acctgaactc 840 ctgggtggac
cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 900
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag
960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc
gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg
tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg caaggtctcc
aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca aagccaaagg
gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200 cgggatgagc
tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca 1260
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg
1320 cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac
cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca tgctccgtga
tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct ctccctgtct
ccgggtaaat ga 1482 <210> SEQ ID NO 46 <211> LENGTH: 493
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 46 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile
Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310
315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435
440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 47 <211> LENGTH:
1500 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 47 aagcttgccg ccatggaagc
cccagcgcag cttctcttcc tcctgctact ctggctccca 60 gataccaccg
gagaaattgt gttgacacag tctccagcca ccctgtcttt gtctccaggc 120
gaaagagcca ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac
180 caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac
cttagcagaa 240 ggaattccag ccaggttcag tggcagtgga tccgggacag
acttcactct caccatcagc 300 agcctagagc ctgaagattt tgcagtttat
tactgtcaac atcattccga taatccgtgg 360 acattcggcc aagggaccaa
ggtggaaatc aaaggtggcg gcggctcggg cggtggtgga 420 tctggaggag
gtgggaccgg tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480
cccggagagt ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat
540 atgaactggg tgcgccagat gcccgggaaa ggcctcgagt ggatgggcaa
tattgatcct 600 tattatggtg gtactaccta caaccggaag ttcaagggcc
aggtcactat ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg
agcagcctga aggcctcgga caccgccatg 720 tattactgtg cacgctcagt
cggccctttc gactactggg gccagggcac cctggtcact 780 gtctcctctg
atcaggagcc caaatcttct gacaaaactc acacatctcc accgtgccca 840
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
900 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga
aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
1260 ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 1320 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 1440 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atgatctaga 1500 <210> SEQ ID
NO 48 <211> LENGTH: 493 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 48 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145
150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265
270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390
395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO
49 <211> LENGTH: 356 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 49
gctagcgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg agagtctctg
60 aagatttcct gtaagggatc cggttactca ttcactggct acaatatgaa
ctgggtgcgc 120 cagatgcccg ggaaaggcct ggagtggatg ggcaatattg
atccttatta tggtggtact 180 acctacaacc ggaagttcaa gggccaggtc
actatctccg ccgacaagtc catcagcacc 240 gcctacctgc aatggagcag
cctgaaggcc tcggacaccg ccatgtatta ctgtgcgcgc 300 tcagtcggcc
ctatggacgt ctggggccaa ggcaccactg tcactgtctc ctcgag 356 <210>
SEQ ID NO 50 <211> LENGTH: 143 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 50 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr
Gly 130 135 140 <210> SEQ ID NO 51 <211> LENGTH: 1381
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 51 aagcttgccg ccatggaagc cccagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gagaaattgt
gttgacacag tctccagcca ccctgtcttt gtctccaggc 120 gaaagagcca
ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac 180
caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa
240 ggaattccag ccaggttcag tggcagtgga tccgggacag acttcactct
caccatcagc 300 agcctagagc ctgaagattt tgcagtttat tactgtcaac
atcattccga taatccgtgg 360 acattcggcc aagggaccaa ggtggaaatc
aaaggtggcg gtggctcggg cggtggtgga 420 tctggaggag gtgggaccgg
tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480 cccggagagt
ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat 540
atgaactggg tgcgccagat gcccgggaaa ggcctcgagt ggatgggcaa tattgatcct
600 tattatggtg gtactaccta caaccggaag ttcaagggcc aggtcactat
ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg agcagcctga
aggcctcgga caccgccatg 720 tattactgtg cacgctcagt cggccctttc
gactcctggg gccagggcac cctggtcact 780 gtctcctctg atcaggagcc
caaatcttct gacaaaactc acacatctcc accgtgccca 840 gcacctgaac
tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 900
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200 ctgcccccat
cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa 1260
ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
1320 tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta
cagcaagctc 1380 a 1381 <210> SEQ ID NO 52 <211> LENGTH:
493 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 52 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile
Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Phe Asp Ser Trp
Gly Gln Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310
315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435
440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 53 <211> LENGTH:
356 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 53 gctagcgagg tgcagctggt gcagtctgga
gcagaggtga aaaagcccgg agagtctctg 60 aagatttcct gtaagggatc
cggttactca ttcactggct acaatatgaa ctgggtgcgc 120 cagatgcccg
ggaaaggcct ggagtggatg ggcaatattg atccttatta tggtggtact 180
acctacaacc ggaagttcaa gggccaggtc actatctccg ccgacaagtc catcagcacc
240 gcctacctgc aatggagcag cctgaaggcc tcggacaccg ccatgtatta
ctgtgcgcgc 300 tcagtcggcc cttttgaccc ctggggccaa ggcaccctgg
tcactgtctc ctcgag 356 <210> SEQ ID NO 54 <211> LENGTH:
143 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 54 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly 130 135 140 <210> SEQ ID NO 55
<211> LENGTH: 356 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 55 gctagcgagg
tgcagctggt gcagtctgga gcagaggtga aaaagcccgg agagtctctg 60
aagatttcct gtaagggatc cggttactca ttcactggct acaatatgaa ctgggtgcgc
120 cagatgcccg ggaaaggcct ggagtggatg ggcaatattg atccttatta
tggtggtact 180 acctacaacc ggaagttcaa gggccaggtc actatctccg
ccgacaagtc catcagcacc 240 gcctacctgc aatggagcag cctgaaggcc
tcggacaccg ccatgtatta ctgtgcgcgc 300 tcagtcggcc cttttcagca
ctggggccaa ggcaccctcg tcactgtctc ctcgag 356 <210> SEQ ID NO
56 <211> LENGTH: 143 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 56 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly 130 135 140
<210> SEQ ID NO 57 <211> LENGTH: 356 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 57 gctagcgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg
agagtctctg 60 aagatttcct gtaagggatc cggttactca ttcactggct
acaatatgaa ctgggtgcgc 120 cagatgcccg ggaaaggcct ggagtggatg
ggcaatattg atccttatta tggtggtact 180 acctacaacc ggaagttcaa
gggccaggtc actatctccg ccgacaagtc catcagcacc 240 gcctacctgc
aatggagcag cctgaaggcc tcggacaccg ccatgtatta ctgtgcgcgc 300
tcagtcggcc cttttgacgt ctggggccaa ggcaccatgg tcactgtctc ctcgag 356
<210> SEQ ID NO 58 <211> LENGTH: 143 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 58 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr
Gly 130 135 140 <210> SEQ ID NO 59 <211> LENGTH: 356
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 59 gctagcgagg tgcagctggt gcagtctgga
gcagaggtga aaaagcccgg agagtctctg 60 aagatttcct gtaagggatc
cggttactca ttcactggct acaatatgaa ctgggtgcgc 120 cagatgcccg
ggaaaggcct ggagtggatg ggcaatattg atccttatta tggtggtact 180
acctacaacc ggaagttcaa gggccaggtc actatctccg ccgacaagtc catcagcacc
240 gcctacctgc aatggagcag cctgaaggcc tcggacaccg ccatgtatta
ctgtgcgcgc 300 tcagtcggcc cttttgacat ctggggccaa ggcaccatgg
tcactgtctc ctcgag 356 <210> SEQ ID NO 60 <211> LENGTH:
143 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 60 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly 130 135 140 <210> SEQ ID NO 61
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 61 Arg Ala Ser
Glu Asn Val Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID NO 62
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 62 Arg Thr Ser
Glu Asn Val Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID NO 63
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 63 Gly Tyr Asn
Met Asn 1 5 <210> SEQ ID NO 64 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 64 Phe Ala Lys Thr Leu Ala Glu 1 5
<210> SEQ ID NO 65 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 65 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg
Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO 66 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 66 Gln His His Ser Asp Asn
Pro Trp Thr 1 5 <210> SEQ ID NO 67 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 67 Ser Val Gly Pro Phe Asp Tyr 1 5
<210> SEQ ID NO 68 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 68 Ser Val Gly Pro Phe Asp Ser 1 5 <210> SEQ ID NO
69 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 69 Ser
Val Gly Pro Met Asp Tyr 1 5 <210> SEQ ID NO 70 <400>
SEQUENCE: 70 000 <210> SEQ ID NO 71 <400> SEQUENCE: 71
000 <210> SEQ ID NO 72 <400> SEQUENCE: 72 000
<210> SEQ ID NO 73 <400> SEQUENCE: 73 000 <210>
SEQ ID NO 74 <400> SEQUENCE: 74 000 <210> SEQ ID NO 75
<400> SEQUENCE: 75 000 <210> SEQ ID NO 76 <400>
SEQUENCE: 76 000 <210> SEQ ID NO 77 <400> SEQUENCE: 77
000 <210> SEQ ID NO 78 <400> SEQUENCE: 78 000
<210> SEQ ID NO 79 <211> LENGTH: 1500 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 79 aagcttgccg ccatggaagc cccagcgcag cttctcttcc tcctgctact
ctggctccca 60 gataccaccg gagaaattgt gttgacacag tctccagcca
ccctgtcttt gtctccaggc 120 gaaagagcca ccctctcctg ccgagcaagt
gaaaatgttt acagctactt agcctggtac 180 caacagaaac ctggccaggc
tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa 240 ggaattccag
ccaggttcag tggcagtgga tccgggacag acttcactct caccatcagc 300
agcctagagc ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg
360 acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg
cggtggtgga 420 tctggaggag gtgggaccgg tgaggtgcag ctggtgcagt
ctggagcaga ggtgaaaaag 480 cccggagagt ctctgaagat ttcctgtaag
ggatccggtt actcattcac tggctacaat 540 atgaactggg tgcgccagat
gcccgggaaa ggcctcgagt ggatgggcaa tattgatcct 600 tattatggtg
gtactaccta caaccggaag ttcaagggcc aggtcactat ctccgccgac 660
aagtccatca gcaccgccta cctgcaatgg agcagcctga aggcctcgga caccgccatg
720 tattactgtg cacgctcagt cggccctttc gacctctggg gcagaggcac
cctggtcact 780 gtctcctctg atcaggagcc caaatcttct gacaaaactc
acacatctcc accgtgccca 840 gcacctgaac tcctgggtgg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 900 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 960 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1020
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
1080 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 1140 cccatcgaga aaaccatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 1200 ctgcccccat cccgggatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 1260 ggcttctatc caagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 1320 tacaagacca
cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc 1380
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
1440 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa
atgatctaga 1500 <210> SEQ ID NO 80 <211> LENGTH: 493
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 80 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile
Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Phe Asp Leu Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310
315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435
440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 81 <211> LENGTH:
1494 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 81 aagcttgccg ccatggaagc
cccagctcag cttctcttcc tcctgctact ctggctccca 60 gataccaccg
gagaaattgt gttgacacag tctccagcca ccctgtcttt gtctccaggc 120
gaaagagcca ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac
180 caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac
cttagcagaa 240 ggaattccag ccaggttcag tggcagtgga tccgggacag
acttcactct caccatcagc 300 agcctagagc ctgaagattt tgcagtttat
tactgtcaac atcattccga taatccgtgg 360 acattcggcc aagggaccaa
ggtggaaatc aaaggtggcg gtggctcggg cggtggtgga 420 tctggaggag
gtggggctag cgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480
cccggagagt ctctgaagat ttcctgtaag ggatccggtt actcattcac tagctacaat
540 atgaactggg tgcgccagat gcccgggaaa ggcctggagt ggatgggcaa
tattgatcct 600 tattatggtg gtactaacta cgcccagaag ttccagggcc
aggtcactat ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg
agcagcctga aggcctcgga caccgccatg 720 tattactgtg cacgctcagt
cggccctatg gactactggg gccgcggcac cctggtcact 780 gtctcctctg
atcaggagcc caaatcttct gacaaaactc acacatctcc accgtgccca 840
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
900 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga
aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
1260 ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 1320 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 1440 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 1494 <210> SEQ ID NO 82
<211> LENGTH: 493 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 82 Met Glu Ala
Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn
35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu
Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala
Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140 Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155
160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Asn
165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Asn Tyr Ala
Gln Lys Phe Gln 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro
Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser
Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280
285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405
410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 83
<211> LENGTH: 1476 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 83
aagcttgccg ccatggaagc cccagcgcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gagaaattgt gttgacacag tctccagcca ccctgtcttt
gtctccaggc 120 gaaagagcca ccctctcctg ccgagcaagt gagaatgttt
acagctactt agcctggtac 180 caacagaaac ctggccaggc tcctaggctc
ctcatctatt ttgcaaaaac cttagcagaa 240 gggattccag ccagattcag
tggcagtggt tccgggacag acttcactct caccatcagc 300 agcctagagc
ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg 360
acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg cggtggtgga
420 tctggaggag gtgggagcgg aggaggagct agcgaggtgc agctggtgca
gtctggagca 480 gaggtgaaaa agcccggaga gtctctgaag atttcctgta
agggatccgg ttactcattc 540 actggctaca atatgaactg ggtgcgccag
atgcccggga aaggcctcga atggatgggc 600 aatattgatc cttattatgg
tggtactacc tacaaccgga agttcaaggg ccaggtcact 660 atctccgccg
acaagtccat cagcaccgcc tacctgcaag gagcagcctg aaggcctcgg 720
acaccgccat gtattactgt gcacgctcag tcggcccttt cgactcctgg ggccagggca
780 ccctggtcac tgtctcgagt tgtccaccgt gcccagcacc tgaactcctg
ggtggaccgt 840 cagtcttcct cttcccccca aaacccaagg acaccctcat
gatctcccgg acccctgagg 900 tcacatgcgt ggtggtggac gtgagccacg
aagaccctga ggtcaagttc aactggtacg 960 tggacggcgt ggaggtgcat
aatgccaaga caaagccgcg ggaggagcag tacaacagca 1020 cgtaccgtgt
ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt 1080
acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag
1140 ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg
gatgagctga 1200 ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt
ctatccaagc gacatcgccg 1260 tggagtggga gagcaatggg cagccggaga
acaactacaa gaccacgcct cccgtgctgg 1320 actccgacgg ctccttcttc
ctctacagca agctcaccgt ggacaagagc aggtggcagc 1380 aggggaacgt
cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga 1440
agagcctctc cctgtctccg ggtaaatgac tctaga 1476 <210> SEQ ID NO
84 <211> LENGTH: 485 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 84 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 130 135 140
Gly Ala Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 145
150 155 160 Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr
Ser Phe 165 170 175 Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro
Gly Lys Gly Leu 180 185 190 Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr
Gly Gly Thr Thr Tyr Asn 195 200 205 Arg Lys Phe Lys Gly Gln Val Thr
Ile Ser Ala Asp Lys Ser Ile Ser 210 215 220 Thr Ala Tyr Leu Gln Trp
Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 225 230 235 240 Tyr Tyr Cys
Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 245 250 255 Thr
Leu Val Thr Val Ser Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu 260 265
270 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
275 280 285 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val 290 295 300 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val 305 310 315 320 Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser 325 330 335 Thr Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu 340 345 350 Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 355 360 365 Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 370 375 380 Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 385 390
395 400 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala 405 410 415 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr 420 425 430 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu 435 440 445 Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser 450 455 460 Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser 465 470 475 480 Leu Ser Pro Gly
Lys 485 <210> SEQ ID NO 85 <211> LENGTH: 1494
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 85 aagcttgccg ccatggaagc cccagctcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gagaaattgt
gttgacacag tctccagcca ccctgtcttt gtctccaggc 120 gaaagagcca
ccctctcctg ccgaacaagt gaaaatgttt acagctactt agcctggtac 180
caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa
240 ggaattccag ccaggttcag tggcagtgga tccgggacag acttcactct
caccatcagc 300 agcctagagc ctgaagattt tgcagtttat tactgtcaac
atcattccga taatccgtgg 360 acattcggcc aagggaccaa ggtggaaatc
aaaggtggcg gtggctcggg cggtggtgga 420 tctggaggag gtgggaccgg
tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480 cccggagagt
ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat 540
atgaactggg tgcgccagat gcccgggaaa ggcctggagt ggatgggcaa tattgatcct
600 tattatggtg gtactaccta caaccggaag ttcaagggcc aggtcactat
ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg agcagcctga
aggcctcgga caccgccatg 720 tattactgtg cacgctcagt cggccctatg
gactactggg gccgcggcac cctggtcact 780 gtctcctctg atcaggagcc
caaatcttct gacaaaactc acacatctcc accgtgccca 840 gcacctgaac
tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 900
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200 ctgcccccat
cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa 1260
ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
1320 tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta
cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg aacgtcttct
catgctccgt gatgcatgag 1440 gctctgcaca accactacac gcagaagagc
ctctccctgt ctccgggtaa atga 1494 <210> SEQ ID NO 86
<211> LENGTH: 493 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 86 Met Glu Ala
Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn
35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu
Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala
Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140 Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155
160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn
165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn
Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro
Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser
Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280
285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405
410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 87
<211> LENGTH: 1494 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 87
aagcttgccg ccatggaagc cccagctcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gtgaaattgt gttgacacag tctccagcca ccctgtcttt
gtctccaggc 120 gaaagagcca ccctctcctg ccgaacaagt gaaaatgttt
acagctactt agcctggtac 180 caacagaaac ctggccaggc tcctaggctc
ctcatctatt ttgcaaaaac cttagcagaa 240 ggaattccag ccaggttcag
tggcagtgga tccgggacag acttcactct caccatcagc 300 agcctagagc
ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg 360
acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg cggtggtgga
420 tctggaggag gtggggctag cgaggtgcag ctggtgcagt ctggagcaga
ggtgaaaaag 480 cccggagagt ctctgaggat ttcctgtaag ggatccggtt
actcattcac tggctacaat 540 atgaactggg tgcgccagat gcccgggaaa
ggcctggagt ggatgggcaa tattgatcct 600 tattatggtg gtactaccta
caaccggaag ttcaagggcc aggtcactat ctccgccgac 660 aagtccatca
gcaccgccta cctgcaatgg agcagcctga aggcctcgga caccgccatg 720
tattactgtg cacgctcagt cggccctatg gactactggg gccgcggcac cctggtcact
780 gtctcctctg atcaggagcc caaatcttct gacaaaactc acacatctcc
accgtgccca 840 gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc
ccccaaaacc caaggacacc 900 ctcatgatct cccggacccc tgaggtcaca
tgcgtggtgg tggacgtgag ccacgaagac 960 cctgaggtca agttcaactg
gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1020 ccgcgggagg
agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1080
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc
1140 cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca
ggtgtacacc 1200 ctgcccccat cccgggatga gctgaccaag aaccaggtca
gcctgacctg cctggtcaaa 1260 ggcttctatc caagcgacat cgccgtggag
tgggagagca atgggcagcc ggagaacaac 1320 tacaagacca cgcctcccgt
gctggactcc gacggctcct tcttcctcta cagcaagctc 1380 accgtggaca
agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag 1440
gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 1494
<210> SEQ ID NO 88 <211> LENGTH: 493 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 88 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala
Ser Glu 130 135 140 Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Glu Ser 145 150 155 160 Leu Arg Ile Ser Cys Lys Gly Ser Gly
Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met
Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val
Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln
Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230
235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val
Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355
360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465 470 475
480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 89 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 89 gagcccaaat cttgtgacaa aactcacaca tgtccaccgt gccca 45
<210> SEQ ID NO 90 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 90 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 91 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 91 gagcccaaat cttctgacaa aactcacaca
tgtccaccgt gccca 45 <210> SEQ ID NO 92 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 92 Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> SEQ ID NO 93
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 93 gagcccaaat
cttctgacaa aactcacaca tgtccaccgt gctca 45 <210> SEQ ID NO 94
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 94 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 95 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 95 gagcccaaat cttgtgacaa aactcacaca tgtccaccga gctca 45
<210> SEQ ID NO 96 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 96 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 97 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 97 gagcccaaat cttctgacaa aactcacaca
tctccaccga gccca 45 <210> SEQ ID NO 98 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 98 Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser Pro Pro Ser Pro 1 5 10 15 <210> SEQ ID NO 99
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 99 gagcccaaat
cttctgacaa aactcacaca tctccaccga gctca 45 <210> SEQ ID NO 100
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 100 Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 1 5 10 15
<210> SEQ ID NO 101 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 101 gagcccaaat cttgtgacaa aactcacaca tctccaccgt gccca 45
<210> SEQ ID NO 102 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 102 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 103 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 103 gagcccaaat cttgtgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 104 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 104 Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Ser Pro Pro Cys Ser 1 5 10 15 <210> SEQ ID NO 105
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 105 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gccca 45 <210> SEQ ID NO 106
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 106 Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 1 5 10 15
<210> SEQ ID NO 107 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 107 gagcccaaat cttctgacaa aactcacaca tctccaccgt gctca 45
<210> SEQ ID NO 108 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 108 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Cys Ser 1 5 10 15 <210> SEQ ID NO 109 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 109 gagcccaaat cttgtgacaa aactcacaca
tctccaccga gccca 45 <210> SEQ ID NO 110 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 110 Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Ser Pro Pro Ser Pro 1 5 10 15 <210> SEQ ID NO 111
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 111 gagcccaaat
cttgtgacaa aactcacaca tctccaccga gctca 45 <210> SEQ ID NO 112
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 112 Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 1 5 10 15
<210> SEQ ID NO 113 <400> SEQUENCE: 113 000 <210>
SEQ ID NO 114 <400> SEQUENCE: 114 000 <210> SEQ ID NO
115 <211> LENGTH: 19 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 115 Val
Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 1 5 10
15 Ser Pro Ser <210> SEQ ID NO 116 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 116 Val Pro Pro Pro Pro Pro 1 5
<210> SEQ ID NO 117 <211> LENGTH: 186 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 117 gagctcaaaa ctcctctcgg ggatacgacc catacgtgtc
cccgctgtcc tgaaccgaag 60 tcctgcgata cgcctccgcc atgtccacgg
tgcccagagc ccaaatcatg cgatacgccc 120 ccaccgtgtc cccgctgtcc
tgaaccaaag tcatgcgata ccccaccacc atgtccaaga 180 tgccca 186
<210> SEQ ID NO 118 <211> LENGTH: 62 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 118 Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys
Pro Arg Cys 1 5 10 15 Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro
Cys Pro Arg Cys Pro 20 25 30 Glu Pro Lys Ser Cys Asp Thr Pro Pro
Pro Cys Pro Arg Cys Pro Glu 35 40 45 Pro Lys Ser Cys Asp Thr Pro
Pro Pro Cys Pro Arg Cys Pro 50 55 60 <210> SEQ ID NO 119
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 119 gagcccaaat
cttctgacac acctccccca tgcccacggt gcccc 45 <210> SEQ ID NO 120
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 120 Glu Pro
Lys Ser Ser Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 1 5 10 15
<210> SEQ ID NO 121 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 121 gagcccaaat cttgtgacac acctccccca tccccacggt cccca 45
<210> SEQ ID NO 122 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 122 Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Ser Pro Arg
Ser Pro 1 5 10 15 <210> SEQ ID NO 123 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 123 gagcccaaat cttctgacac acctccccca
tccccacggt cccca 45 <210> SEQ ID NO 124 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 124 Glu Pro Lys Ser Ser Asp Thr Pro
Pro Pro Ser Pro Arg Ser Pro 1 5 10 15 <210> SEQ ID NO 125
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 125 gagcccaaat
cttgtgacac acctccccca tccccacggt gccca 45 <210> SEQ ID NO 126
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 126 Glu Pro
Lys Ser Cys Asp Thr Pro Pro Pro Ser Pro Arg Cys Pro 1 5 10 15
<210> SEQ ID NO 127 <211> LENGTH: 58 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 127 Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala
Gln Pro Gln 1 5 10 15 Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala
Pro Ala Thr Thr Arg 20 25 30 Asn Thr Gly Arg Gly Gly Glu Glu Lys
Lys Lys Glu Lys Glu Lys Glu 35 40 45 Glu Gln Glu Glu Arg Glu Thr
Lys Thr Pro 50 55 <210> SEQ ID NO 128 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 128 Arg Thr Ser Gln Asn Val Tyr Ser
Tyr Leu Ala 1 5 10 <210> SEQ ID NO 129 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 129 Arg Thr Ser Glu Ser Val Tyr Ser
Tyr Leu Ala 1 5 10 <210> SEQ ID NO 130 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 130 Arg Ala Ser Gln Ser Val Tyr Ser
Tyr Leu Ala 1 5 10 <210> SEQ ID NO 131 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 131 Arg Ala Ser Gln Ser Val Ser Ser
Tyr Leu Ala 1 5 10 <210> SEQ ID NO 132 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 132 Arg Ala Ser Gln Ser Val Ser Tyr
Tyr Leu Ala 1 5 10 <210> SEQ ID NO 133 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 133 Ser Tyr Met Asn Met 1 5
<210> SEQ ID NO 134 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 134 Ser Tyr Trp Ile Gly 1 5 <210> SEQ ID NO 135
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 135 Ala Ala
Ser Ser Leu Gln Ser 1 5 <210> SEQ ID NO 136 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 136 Gly Ala Ser Thr Arg Ala
Thr 1 5 <210> SEQ ID NO 137 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 137 Asp Ala Ser Asn Arg Ala Thr 1 5
<210> SEQ ID NO 138 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 138 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro
Ser Phe Gln 1 5 10 15 Gly <210> SEQ ID NO 139 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 139 Arg Ile Asp Pro Ser Asp
Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210>
SEQ ID NO 140 <211> LENGTH: 30 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr 20 25 30 <210> SEQ ID NO 141 <211> LENGTH:
30 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 141 Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Ser 20 25 30 <210> SEQ ID NO 142
<400> SEQUENCE: 142 000 <210> SEQ ID NO 143 <211>
LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 143 Glu Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Thr Val Lys Ile
Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr 20 25 30 <210> SEQ ID
NO 144 <211> LENGTH: 30 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 144 Glu
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10
15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 20 25 30
<210> SEQ ID NO 145 <211> LENGTH: 30 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 145 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr
Ser Phe Thr 20 25 30 <210> SEQ ID NO 146 <211> LENGTH:
30 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 146 Gln Val Gln Leu Val Gln Ser Gly
Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> SEQ ID NO 147
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 147 Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 1 5 10 <210>
SEQ ID NO 148 <400> SEQUENCE: 148 000 <210> SEQ ID NO
149 <400> SEQUENCE: 149 000 <210> SEQ ID NO 150
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 150 Trp Val
Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 1 5 10 <210>
SEQ ID NO 151 <211> LENGTH: 14 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 151 Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
Gly 1 5 10 <210> SEQ ID NO 152 <400> SEQUENCE: 152 000
<210> SEQ ID NO 153 <400> SEQUENCE: 153 000 <210>
SEQ ID NO 154 <211> LENGTH: 32 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 154 Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala
Tyr Met Glu 1 5 10 15 Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 155 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 155 Arg Val Thr Ile Thr Ala
Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30
<210> SEQ ID NO 156 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 156 Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala
Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 157 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 157 Arg Val Thr Ile Thr Ala
Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 20 25 30
<210> SEQ ID NO 158 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 158 Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu Gln 1 5 10 15 Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 159 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 159 His Val Thr Ile Ser Ala
Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 1 5 10 15 Trp Ser Ser Leu
Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 20 25 30
<210> SEQ ID NO 160 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 160 Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala
Tyr Leu Gln 1 5 10 15 Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 161 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 161 Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 162 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 162 Trp Gly Arg Gly Thr Leu
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 163 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 163 Trp Gly Gln Gly Thr Met
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 164 <400>
SEQUENCE: 164 000 <210> SEQ ID NO 165 <400> SEQUENCE:
165 000 <210> SEQ ID NO 166 <400> SEQUENCE: 166 000
<210> SEQ ID NO 167 <400> SEQUENCE: 167 000 <210>
SEQ ID NO 168 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 168 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 1 5 10
<210> SEQ ID NO 169 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 169 Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 1 5 10
<210> SEQ ID NO 170 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 170 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val
Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys 20 <210>
SEQ ID NO 171 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 171 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys 20 <210>
SEQ ID NO 172 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 172 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 173 <400> SEQUENCE: 173 000 <210> SEQ ID NO
174 <400> SEQUENCE: 174 000 <210> SEQ ID NO 175
<211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 175 Asn Ile
Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr Ile Thr Cys 20 <210> SEQ ID NO 176
<400> SEQUENCE: 176 000 <210> SEQ ID NO 177 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 177 Ala Ile Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr
Ile Thr Cys 20 <210> SEQ ID NO 178 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 178 Asp Ile Gln Leu Thr Gln Ser Pro
Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys 20 <210> SEQ ID NO 179 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 179 Ala Ile Arg Met Thr Gln Ser Pro Phe Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20
<210> SEQ ID NO 180 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 180 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 181 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 181 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 182 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 182 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
Ile Tyr 1 5 10 15 <210> SEQ ID NO 183 <400> SEQUENCE:
183 000 <210> SEQ ID NO 184 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 184 Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> SEQ ID NO 185
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 185 Trp Tyr
Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 186 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 186 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu
Ile Tyr 1 5 10 15 <210> SEQ ID NO 187 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 187 Trp Phe Gln Gln Lys Pro Gly Lys
Val Pro Lys His Leu Ile Tyr 1 5 10 15 <210> SEQ ID NO 188
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 188 Trp Phe
Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 189 <400> SEQUENCE: 189 000 <210>
SEQ ID NO 190 <400> SEQUENCE: 190 000 <210> SEQ ID NO
191 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 191 Trp
Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe Ile Tyr 1 5 10 15
<210> SEQ ID NO 192 <400> SEQUENCE: 192 000 <210>
SEQ ID NO 193 <400> SEQUENCE: 193 000 <210> SEQ ID NO
194 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 194 Gly
Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 1 5 10
15 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys
20 25 30 <210> SEQ ID NO 195 <211> LENGTH: 32
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 195 Gly Ile Pro Ala Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 20 25 30 <210> SEQ ID
NO 196 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 196 Gly
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10
15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
20 25 30 <210> SEQ ID NO 197 <211> LENGTH: 32
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 197 Gly Val Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 20 25 30 <210> SEQ ID
NO 198 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 198 Gly
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 1 5 10
15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
20 25 30 <210> SEQ ID NO 199 <400> SEQUENCE: 199 000
<210> SEQ ID NO 200 <400> SEQUENCE: 200 000 <210>
SEQ ID NO 201 <400> SEQUENCE: 201 000 <210> SEQ ID NO
202 <400> SEQUENCE: 202 000 <210> SEQ ID NO 203
<211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 203 Gly Val
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 1 5 10 15
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20
25 30 <210> SEQ ID NO 204 <400> SEQUENCE: 204 000
<210> SEQ ID NO 205 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 205 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
Glu Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe
Ala Thr Tyr Tyr Cys 20 25 30 <210> SEQ ID NO 206 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 206 Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys 1 5 10 <210> SEQ ID NO 207 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 207 Phe Gly Gln Gly Thr Lys
Leu Glu Ile Lys 1 5 10 <210> SEQ ID NO 208 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 208 Phe Gly Pro Gly Thr Lys
Val Asp Ile Lys 1 5 10 <210> SEQ ID NO 209 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 209 Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys 1 5 10 <210> SEQ ID NO 210 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 210 Phe Gly Gln Gly Thr Arg
Leu Glu Ile Lys 1 5 10 <210> SEQ ID NO 211 <400>
SEQUENCE: 211 000 <210> SEQ ID NO 212 <400> SEQUENCE:
212 000 <210> SEQ ID NO 213 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 213 Ser Val Gly Pro Met Asp Val 1 5
<210> SEQ ID NO 214 <400> SEQUENCE: 214 000 <210>
SEQ ID NO 215 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 215 Ser Val Gly Pro Phe Asp Pro 1 5 <210> SEQ ID NO
216 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 216 Ser
Val Gly Pro Phe Gln His 1 5 <210> SEQ ID NO 217 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 217 Ser Val Gly Pro Phe Asp
Val 1 5 <210> SEQ ID NO 218 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 218 Ser Val Gly Pro Phe Asp Ile 1 5
<210> SEQ ID NO 219 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 219 Ser Val Gly Pro Phe Asp Leu 1 5 <210> SEQ ID NO
220 <400> SEQUENCE: 220 000 <210> SEQ ID NO 221
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Linker peptide <400> SEQUENCE: 221 Gly Gly Gly
Gly Ser 1 5 <210> SEQ ID NO 222 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Linker peptide
<400> SEQUENCE: 222 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1
5 10 <210> SEQ ID NO 223 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Linker peptide <400>
SEQUENCE: 223 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 1 5 10 15 <210> SEQ ID NO 224 <211> LENGTH: 20
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Linker peptide
<400> SEQUENCE: 224 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20 <210>
SEQ ID NO 225 <211> LENGTH: 25 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Linker peptide <400> SEQUENCE:
225 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 <210> SEQ
ID NO 226 <211> LENGTH: 30 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Linker peptide <400> SEQUENCE: 226 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25
30
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 226
<210> SEQ ID NO 1 <211> LENGTH: 1510 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: TRU-016 polynucleotide <400>
SEQUENCE: 1 aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat
cagtgcttca 60 gtcataattg ccagaggagt cgacatccag atgactcagt
ctccagcctc cctatctgca 120 tctgtgggag agactgtcac catcacatgt
cgaacaagtg aaaatgttta cagttatttg 180 gcttggtatc agcagaaaca
gggaaaatct cctcagctcc tggtctcttt tgcaaaaacc 240 ttagcagaag
gtgtgccatc aaggttcagt ggcagtggat caggcacaca gttttctctg 300
aagatcagca gcctgcagcc tgaagattct ggaagttatt tctgtcaaca tcattccgat
360 aatccgtgga cgttcggtgg aggcaccgaa ctggagatca aaggtggcgg
tggctcgggc 420 ggtggtgggt cgggtggcgg cggatcgtca gcggtccagc
tgcagcagtc tggacctgag 480 tcggaaaagc ctggcgcttc agtgaagatt
tcctgcaagg cttctggtta ctcattcact 540 ggctacaata tgaactgggt
gaagcagaat aatggaaaga gccttgagtg gattggaaat 600 attgatcctt
attatggtgg tactacctac aaccggaagt tcaagggcaa ggccacattg 660
actgtagaca aatcctccag cacagcctac atgcagctca agagtctgac atctgaggac
720 tctgcagtct attactgtgc aagatcggtc ggccctatgg actactgggg
tcaaggaacc 780 tcagtcaccg tctcttcaga tctggagccc aaatcttctg
acaaaactca cacatctcca 840 ccgtgcccag cacctgaact cttgggtgga
ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc tcatgatctc
ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960 cacgaagacc
ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1020
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 1140 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag
ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag gcttctatcc
aagcgacatc gccgtggagt gggagagcaa tgggcaaccg 1320 gagaacaact
acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 1380
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaaa 1500 tgagtctaga 1510 <210> SEQ ID NO 2 <211>
LENGTH: 496 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
TRU-016 peptide <400> SEQUENCE: 2 Met Asp Phe Gln Val Gln Ile
Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Ile Ala Arg
Gly Val Asp Ile Gln Met Thr Gln Ser Pro Ala 20 25 30 Ser Leu Ser
Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr 35 40 45 Ser
Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 50 55
60 Lys Ser Pro Gln Leu Leu Val Ser Phe Ala Lys Thr Leu Ala Glu Gly
65 70 75 80 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe
Ser Leu 85 90 95 Lys Ile Ser Ser Leu Gln Pro Glu Asp Ser Gly Ser
Tyr Phe Cys Gln 100 105 110 His His Ser Asp Asn Pro Trp Thr Phe Gly
Gly Gly Thr Glu Leu Glu 115 120 125 Ile Lys Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 130 135 140 Ser Ser Ala Val Gln Leu
Gln Gln Ser Gly Pro Glu Ser Glu Lys Pro 145 150 155 160 Gly Ala Ser
Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 165 170 175 Gly
Tyr Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu 180 185
190 Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg
195 200 205 Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
Ser Thr 210 215 220 Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp
Ser Ala Val Tyr 225 230 235 240 Tyr Cys Ala Arg Ser Val Gly Pro Met
Asp Tyr Trp Gly Gln Gly Thr 245 250 255 Ser Val Thr Val Ser Ser Asp
Leu Glu Pro Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310
315 320 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
Ala 325 330 335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val 340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435
440 445 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser 450 455 460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala 465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys 485 490 495 <210> SEQ ID NO 3
<211> LENGTH: 1518 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: TRU-015 polynucleotide <400> SEQUENCE: 3
aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca
60 gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct
gtctgcatct 120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa
gtgtaagtta catgcactgg 180 taccagcaga agccaggatc ctcccccaaa
ccctggattt atgccccatc caacctggct 240 tctggagtcc ctgctcgctt
cagtggcagt gggtctggga cctcttactc tctcacaatc 300 agcagagtgg
aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca 360
cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt
420 ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc
tgagtcggtg 480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg
gctacacatt taccagttac 540 aatatgcact gggtaaagca gacacctaga
cagggcctgg aatggattgg agctatttat 600 ccaggaaatg gtgatacttc
ctacaatcag aagttcaagg gcaaggccac actgactgta 660 gacaaatcct
ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg 720
gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg
780 ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttgtga
caaaactcac 840 acatctccac cgtgctcagc acctgaactc ctgggtggac
cgtcagtctt cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc
cggacccctg aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc
tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc
1140 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg
gcagccccga 1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc
tgaccaagaa ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatcca
agcgacatcg ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta
caagaccacg cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca
gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct
1500 ccgggtaaat gatctaga 1518 <210> SEQ ID NO 4 <211>
LENGTH: 499 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
TRU-015 peptide <400> SEQUENCE: 4 Met Asp Phe Gln Val Gln Ile
Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg
Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45
Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50
55 60 Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val
Pro 65 70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
Leu Thr Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr
Tyr Cys Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala
Gly Thr Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln
Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val
Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175
Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180
185 190 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys
Phe 195 200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser
Thr Ala Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser
Ala Val Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn
Ser Tyr Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val
Thr Val Ser Asp Gln Glu Pro Lys Ser Cys 260 265 270 Asp Lys Thr His
Thr Ser Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305
310 315 320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
Glu Val 325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His
Gln Asp Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425
430 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
435 440 445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val 450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys <210> SEQ
ID NO 5 <211> LENGTH: 1482 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 5
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga
60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga
aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac agctacttag
cctggtacca acagaaacct 180 ggccaggctc ctaggctcct catctatttt
gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg gcagtggatc
cgggacagac ttcactctca ccatcagcag cctagagcct 300 gaagattttg
cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa 360
gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc tggaggaggt
420 gggaccggtg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc
cggagagtct 480 ctgaagattt cctgtaaggg atccggttac tcattcactg
gctacaatat gaactgggtg 540 cgccagatgc ccgggaaagg cctcgagtgg
atgggcaata ttgatcctta ttatggtggt 600 actacctaca accggaagtt
caagggccag gtcactatct ccgccgacaa gtccatcagc 660 accgcctacc
tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca 720
cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt ctcctctgat
780 caggagccca aatcttctga caaaactcac acatctccac cgtgcccagc
acctgaactc 840 ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca
aggacaccct catgatctcc 900 cggacccctg aggtcacatg cgtggtggtg
gacgtgagcc acgaagaccc tgaggtcaag 960 ttcaactggt acgtggacgg
cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1020 cagtacaaca
gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1080
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa
1140 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct
gcccccatcc 1200 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc
tggtcaaagg cttctatcca 1260 agcgacatcg ccgtggagtg ggagagcaat
gggcagccgg agaacaacta caagaccacg 1320 cctcccgtgc tggactccga
cggctccttc ttcctctaca gcaagctcac cgtggacaag 1380 agcaggtggc
agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 1440
cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 1482 <210> SEQ
ID NO 6 <211> LENGTH: 493 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 6 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145
150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265
270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390
395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 7 <211> LENGTH: 1482 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 7 atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga
taccaccgga 60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt
ctccaggcga aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac
agctacttag cctggtacca acagaaacct 180 ggccaggctc ctaggctcct
catctatttt gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg
gcagtggatc cgggacagac ttcactctca ccatcagcag cctagagcct 300
gaagattttg cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa
360 gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc
tggaggaggt 420 gggagctctg aggtgcagct ggtgcagtct ggagcagagg
tgaaaaagcc cggagagtct 480 ctgaagattt cctgtaaggg atccggttac
tcattcactg gctacaatat gaactgggtg 540 cgccagatgc ccgggaaagg
cctcgagtgg atgggcaata ttgatcctta ttatggtggt 600 actacctaca
accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc 660
accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca
720 cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt
ctcctctgat 780 caggagccca aatcttctga caaaactcac acatctccac
cgtgcccagc acctgaactc 840 ctgggtggac cgtcagtctt cctcttcccc
ccaaaaccca aggacaccct catgatctcc 900 cggacccctg aggtcacatg
cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 960 ttcaactggt
acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1020
cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg
1080 aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc
catcgagaaa 1140 accatctcca aagccaaagg gcagccccga gaaccacagg
tgtacaccct gcccccatcc 1200 cgggatgagc tgaccaagaa ccaggtcagc
ctgacctgcc tggtcaaagg cttctatcca 1260 agcgacatcg ccgtggagtg
ggagagcaat gggcagccgg agaacaacta caagaccacg 1320 cctcccgtgc
tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 1380
agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac
1440 cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 1482
<210> SEQ ID NO 8 <211> LENGTH: 493 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 8 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp
Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro
Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser
Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe
Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110
Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115
120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
Glu 130 135 140 Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Glu Ser 145 150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr
Ser Phe Thr Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro
Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr
Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr
Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp
Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235
240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr
245 250 255 Val Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His
Thr Ser 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360
365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465 470 475 480
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 9 <211> LENGTH: 1482 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 9 atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga
taccaccgga 60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt
ctccaggcga aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac
agctacttag cctggtacca acagaaacct 180 ggccaggctc ctaggctcct
catctatttt gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg
gcagtggatc cgggacagac ttcactctca ccatcagcag cctagagcct 300
gaagattttg cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa
360 gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc
tggaggaggt 420 gggaccggtg aggtgcagct ggtgcagtct ggagcagagt
cgaaaaagcc cggagagtct 480 ctgaagattt cctgtaaggg atccggttac
tcattcactg gctacaatat gaactgggtg 540 cgccagatgc ccgggaaagg
cctcgagtgg atgggcaata ttgatcctta ttatggtggt 600 actacctaca
accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc 660
accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca
720 cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt
ctcctctgat 780 caggagccca aatcttctga caaaactcac acatctccac
cgtgcccagc acctgaactc 840 ctgggtggac cgtcagtctt cctcttcccc
ccaaaaccca aggacaccct catgatctcc 900 cggacccctg aggtcacatg
cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 960 ttcaactggt
acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1020
cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg
1080 aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc
catcgagaaa 1140 accatctcca aagccaaagg gcagccccga gaaccacagg
tgtacaccct gcccccatcc 1200 cgggatgagc tgaccaagaa ccaggtcagc
ctgacctgcc tggtcaaagg cttctatcca 1260 agcgacatcg ccgtggagtg
ggagagcaat gggcagccgg agaacaacta caagaccacg 1320 cctcccgtgc
tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 1380
agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac
1440 cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 1482
<210> SEQ ID NO 10 <211> LENGTH: 493 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 10 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser
100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln Ser Gly Ala Glu Ser
Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp
Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215
220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala
225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr
Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340
345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465
470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 11 <211> LENGTH: 1482 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 11 atggaagccc cagctcagct tctcttcctc
ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtca aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg aggtgcagct
ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480 ctgaagattt
cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg 540
cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca aatcttctga
caaaactcac acatctccac cgtgcccagc acctgaactc 840 ctgggtggac
cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 900
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag
960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc
gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg
tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg caaggtctcc
aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca aagccaaagg
gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200 cgggatgagc
tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca 1260
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg
1320 cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac
cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca tgctccgtga
tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct ctccctgtct
ccgggtaaat ga 1482 <210> SEQ ID NO 12 <211> LENGTH: 493
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 12 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile
Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305 310
315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425 430
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435
440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 13 <211> LENGTH:
1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 13 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aagtgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 14 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 14 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Ser 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 15 <211>
LENGTH: 1482 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 15 atggaagccc cagctcagct
tctcttcctc ctgctactct ggctcccaga taccaccgga 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gagcaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtggtggatc tggaggaggt 420 gggaccggtg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaagattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctcgagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctctgat 780 caggagccca
aatcttctga caaaactcac acatctccac cgtgcccagc acctgaactc 840
ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
900 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 960 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 1020 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 1080 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1140 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1200
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca
1260 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 1320 cctcccgtgc tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 1380 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 1440 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 1482 <210> SEQ ID NO 16 <211>
LENGTH: 493 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 16 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50
55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro
Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Lys
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170
175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Asp Gln Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280 285 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 290 295 300
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 305
310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405 410 415 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 420 425
430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys 485 490 <210> SEQ ID NO 17 <211>
LENGTH: 1479 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 17 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gacatccaga
tgactcagtc tccagcctcc ctatctgcat ctgtgggaga gactgtcacc 120
atcacatgtc gaacaagtga aaatgtttac agttatttgg cttggtatca gcagaaacag
180 ggaaaatctc ctcagctcct ggtctctttt gcaaaaacct tagcagaagg
tgtgccatca 240 aggttcagtg gcagtggatc aggcacacag ttttctctga
agatcagcag cctgcagcct 300 gaagattctg gaagttattt ctgtcaacat
cattccgata atccgtggac gttcggtgga 360 ggcaccgaac tggagatcaa
aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc 420 ggagctagcg
aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc cggagagtct 480
ctgaggattt cctgtaaggg atccggttac tcattcactg gctacaatat gaactgggtg
540 cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta
ttatggtggt 600 actacctaca accggaagtt caagggccag gtcactatct
ccgccgacaa gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag
gcctcggaca ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga
ctactggggc cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gcccagcacc tgaactcctg 840
ggtggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
900 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc
1260 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 1479 <210> SEQ ID NO 18 <211>
LENGTH: 492 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 18 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 20 25 30 Ala Ser
Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 35 40 45
Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 50
55 60 Gln Leu Leu Val Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro
Ser 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu
Lys Ile Ser 85 90 95 Ser Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe
Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gly Gly
Thr Glu Leu Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140 Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155 160 Leu Arg
Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175
Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180
185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe
Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr
Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr
Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305
310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425
430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 <210> SEQ ID NO 19 <211> LENGTH:
1479 <212> TYPE: DNA <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 19 atggaagcac cagcgcagct
tctcttcctc ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt
tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc 120
ctctcctgcc gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct
180 ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg
aattccagcc 240 aggttcagtg gcagtggatc cgggacagac ttcactctca
ccatcagcag cctagagcct 300 gaagattttg cagtttatta ctgtcaacat
cattccgata atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa
aggtggcggt ggctcgggcg gtagtggatc tggaggaggt 420 ggagctagcg
cggtccagct gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480
gtgaagattt cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg
540
aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa
atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca tctgaggact
ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga ctactggggt
caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 20 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 20 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Ser Gly
Ser Gly Gly Gly Gly Ala Ser Ala 130 135 140 Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu Lys Pro Gly Ala Ser 145 150 155 160 Val Lys Ile
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr Met 210 215 220 Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 21 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 21 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcc aggtgcagct
ggtggagtct ggtggaggcg tggtccagcc tgggaggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 22 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 22 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Gln 130 135 140 Val Gln Leu Val Glu Ser
Gly Gly Gly Val Val Gln Pro Gly Arg Ser 145 150 155 160 Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240
Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245
250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser
Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350 Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355 360 365
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 370
375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn His 465 470 475 480 Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ
ID NO 23 <211> LENGTH: 1503 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 23
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt
60 gcggtccagc tgcagcagtc tggacctgag tcggaaaagc ctggcgcttc
agtgaagatt 120 tcctgcaagg cttctggtta ctcattcact ggctacaata
tgaactgggt gaagcagaat 180 aatggaaaga gccttgagtg gattggaaat
attgatcctt attatggtgg tactacctac 240 aaccggaagt tcaagggcaa
ggccacattg actgtagaca aatcctccag cacagcctac 300 atgcagctca
agagtctgac atctgaggac tctgcagtct attactgtgc aagatcggtc 360
ggccctatgg actactgggg tcaaggaacc tcagtcaccg tctcttctgg tggcggtggc
420 tcgggcggtg gtgggtcggg tggcggcgga tcaggaggag gcgggagtgc
tagcgaaatt 480 gtgttgacac agtctccagc caccctgtct ttgtctccag
gcgaaagagc caccctctcc 540 tgccgaacaa gtgaaaatgt ttacagctac
ttagcctggt accaacagaa acctggccag 600 gctcctaggc tcctcatcta
ttttgcaaaa accttagcag aaggaattcc agccaggttc 660 agtggcagtg
gatccgggac agacttcact ctcaccatca gcagcctaga gcctgaagat 720
tttgcagttt attactgtca acatcattcc gataatccgt ggacattcgg ccaagggacc
780 aaggtggaaa tcaaaggctc gagcgagccc aaatcttctg acaaaactca
cacatctcca 840 ccgtgcccag cacctgaact cctgggtgga ccgtcagtct
tcctcttccc cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct
gaggtcacat gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa
gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc
cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc
1140 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg
agaaccacag 1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga
accaggtcag cctgacctgc 1260 ctggtcaaag gcttctatcc aagcgacatc
gccgtggagt gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac
gcctcccgtg ctggactccg acggctcctt cttcctctac 1380 agcaagctca
ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa
1500 tga 1503 <210> SEQ ID NO 24 <211> LENGTH: 500
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 24 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Ala Val
Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu 20 25 30 Lys Pro Gly Ala
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr
Gly Tyr Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser 50 55 60
Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 65
70 75 80 Asn Arg Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys
Ser Ser 85 90 95 Ser Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser
Glu Asp Ser Ala 100 105 110 Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro
Met Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Ser Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly 130 135 140 Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile 145 150 155 160 Val Leu Thr
Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 165 170 175 Ala
Thr Leu Ser Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala 180 185
190 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe
195 200 205 Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly
Ser Gly 210 215 220 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
Glu Pro Glu Asp 225 230 235 240 Phe Ala Val Tyr Tyr Cys Gln His His
Ser Asp Asn Pro Trp Thr Phe 245 250 255 Gly Gln Gly Thr Lys Val Glu
Ile Lys Gly Ser Ser Glu Pro Lys Ser 260 265 270 Ser Asp Lys Thr His
Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 305 310
315 320 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
Glu 325 330 335 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
Asn Ser Thr 340 345 350 Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln Asp Trp Leu Asn 355 360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala Leu Pro Ala Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro Arg Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435
440 445 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr 450 455 460 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val 465 470 475 480 Met His Glu Ala Leu His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu 485 490 495 Ser Pro Gly Lys 500 <210>
SEQ ID NO 25 <211> LENGTH: 1488 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 25 atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt
cataattgcc 60 agaggagtcg aaattgtgtt gacacagtct ccagccaccc
tgtctttgtc tccaggcgaa 120 agagccaccc tctcctgccg aacaagtgaa
aatgtttaca gctacttagc ctggtaccaa 180 cagaaacctg gccaggctcc
taggctcctc atctattttg caaaaacctt agcagaagga 240 attccagcca
ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcagc 300
ctagagcctg aagattttgc agtttattac tgtcaacatc attccgataa tccgtggaca
360 ttcggccaag ggaccaaggt ggaaatcaaa ggtggcggtg gctcgggcgg
tggtggatct 420 ggaggaggtg gagctagcgc ggtccagctg cagcagtctg
gacctgagtc ggaaaagcct 480 ggcgcttcag tgaagatttc ctgcaaggct
tctggttact cattcactgg ctacaatatg 540 aactgggtga agcagaataa
tggaaagagc cttgagtgga ttggaaatat tgatccttat 600 tatggtggta
ctacctacaa ccggaagttc aagggcaagg ccacattgac tgtagacaaa 660
tcctccagca cagcctacat gcagctcaag agtctgacat ctgaggactc tgcagtctat
720 tactgtgcaa gatcggtcgg ccctatggac tactggggtc aaggaacctc
agtcaccgtc 780
tcctcgagcg agcccaaatc ttctgacaaa actcacacat ctccaccgtg cccagcacct
840 gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga
caccctcatg 900 atctcccgga cccctgaggt cacatgcgtg gtggtggacg
tgagccacga agaccctgag 960 gtcaagttca actggtacgt ggacggcgtg
gaggtgcata atgccaagac aaagccgcgg 1020 gaggagcagt acaacagcac
gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1080 tggctgaatg
gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 1140
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc
1200 ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt
caaaggcttc 1260 tatccaagcg acatcgccgt ggagtgggag agcaatgggc
agccggagaa caactacaag 1320 accacgcctc ccgtgctgga ctccgacggc
tccttcttcc tctacagcaa gctcaccgtg 1380 gacaagagca ggtggcagca
ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1440 cacaaccact
acacgcagaa gagcctctcc ctgtctccgg gtaaatga 1488 <210> SEQ ID
NO 26 <211> LENGTH: 495 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 26 Met
Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10
15 Val Ile Ile Ala Arg Gly Val Glu Ile Val Leu Thr Gln Ser Pro Ala
20 25 30 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys
Arg Thr 35 40 45 Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp Tyr Gln
Gln Lys Pro Gly 50 55 60 Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala
Lys Thr Leu Ala Glu Gly 65 70 75 80 Ile Pro Ala Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu 85 90 95 Thr Ile Ser Ser Leu Glu
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 100 105 110 His His Ser Asp
Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 115 120 125 Ile Lys
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 130 135 140
Ala Ser Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu Lys Pro 145
150 155 160 Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser
Phe Thr 165 170 175 Gly Tyr Asn Met Asn Trp Val Lys Gln Asn Asn Gly
Lys Ser Leu Glu 180 185 190 Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly
Gly Thr Thr Tyr Asn Arg 195 200 205 Lys Phe Lys Gly Lys Ala Thr Leu
Thr Val Asp Lys Ser Ser Ser Thr 210 215 220 Ala Tyr Met Gln Leu Lys
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 225 230 235 240 Tyr Cys Ala
Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr 245 250 255 Ser
Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 260 265
270 Thr Ser Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
275 280 285 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr 290 295 300 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu 305 310 315 320 Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys 325 330 335 Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser 340 345 350 Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 355 360 365 Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 370 375 380 Ser
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 385 390
395 400 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu 405 410 415 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn 420 425 430 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser 435 440 445 Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg 450 455 460 Trp Gln Gln Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu 465 470 475 480 His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490 495 <210>
SEQ ID NO 27 <211> LENGTH: 1503 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 27 atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga
taccaccggt 60 gcggtccagc tgcagcagtc tggacctgag tcggaaaagc
ctggcgcttc agtgaagatt 120 tcctgcaagg cttctggtta ctcattcact
ggctacaata tgaactgggt gaagcagaat 180 aatggaaaga gccttgagtg
gattggaaat attgatcctt attatggtgg tactacctac 240 aaccggaagt
tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac 300
atgcagctca agagtctgac atctgaggac tctgcagtct attactgtgc aagatcggtc
360 ggccctatgg actactgggg tcaaggaacc tcagtcaccg tctcttctgg
tggcggtggc 420 tcgggcggtg gtgggtcggg tggcggcgga tcaggaggag
gcgggagtgc tagcgaaatt 480 gtgttgacac agtctccagc caccctgtct
ttgtctccag gcgaaagagc caccctctcc 540 tgccgaacaa gtgaaaatgt
ttacagctac ttagcctggt accaacagaa acctggccag 600 gctcctaggc
tcctcatcta ttttgcaaaa accttagcag aaggaattcc agccaggttc 660
agtggcagtg gatccgggac agacttcact ctcaccatca gcagcctaga gcctgaagat
720 tttgcagttt attactgtca acatcattcc gataatccgt ggacattcgg
ccaagggacc 780 aaggtggaaa tcaaaggctc gagcgagccc aaatcttctg
acaaaactca cacatgccca 840 ccgtgcccag cacctgaact cctgggtgga
ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc tcatgatctc
ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960 cacgaagacc
ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1020
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 1140 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag
ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag gcttctatcc
aagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320 gagaacaact
acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 1380
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaaa 1500 tga 1503 <210> SEQ ID NO 28 <211>
LENGTH: 500 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 28 Met Glu Ala Pro Ala Gln
Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly
Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu 20 25 30 Lys Pro
Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 35 40 45
Phe Thr Gly Tyr Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser 50
55 60 Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr 65 70 75 80 Asn Arg Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp
Lys Ser Ser 85 90 95 Ser Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr
Ser Glu Asp Ser Ala 100 105 110 Val Tyr Tyr Cys Ala Arg Ser Val Gly
Pro Met Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Ser Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly 130 135 140 Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Ile 145 150 155 160 Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 165 170 175
Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala 180
185 190 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Phe 195 200 205 Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser
Gly Ser Gly 210 215 220 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Glu Pro Glu Asp 225 230 235 240 Phe Ala Val Tyr Tyr Cys Gln His
His Ser Asp Asn Pro Trp Thr Phe 245 250 255 Gly Gln Gly Thr Lys Val
Glu Ile Lys Gly Ser Ser Glu Pro Lys Ser 260 265 270
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 275
280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser 305 310 315 320 His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu 325 330 335 Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350 Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn 355 360 365 Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 370 375 380 Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 385 390 395
400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
405 410 415 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val 465 470 475 480 Met His Glu Ala Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 485 490 495 Ser Pro Gly
Lys 500 <210> SEQ ID NO 29 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 29 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcg cggtccagct
gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480 gtgaagattt
cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg 540
aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa
atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca tctgaggact
ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga ctactggggt
caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 30 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 30 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Ala 130 135 140 Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu Lys Pro Gly Ala Ser 145 150 155 160 Val Lys Ile
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met
Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr Met 210 215 220 Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 31 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 31 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcg cggtccagct
gcagcagtct ggacctgagt cggaaaagcc tggcgcttca 480 gtgaagattt
cctgcaaggc ttctggttac tcattcactg gctacaatat gaactgggtg 540
aagcagaata atggaaagag ccttgagtgg attggaaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggcaag gccacattga ctgtagacaa
atcctccagc 660 acagcctaca tgcagctcaa gagtctgaca tctgaggact
ctgcagtcta ttactgtgca 720 agatcggtcg gccctatgga ctactggggt
caaggaacct cagtcaccgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat
1080 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat
cgagaaaacc 1140 atctccaaag ccaaagggca gccccgagaa ccacaggtgt
acaccctgcc cccatcccgg 1200 gatgagctga ccaagaacca ggtcagcctg
acctgcctgg tcaaaggctt ctatccaagc 1260 gacatcgccg tggagtggga
gagcaatggg cagccggaga acaactacaa gaccacgcct 1320 cccgtgctgg
actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 1380
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac
1440 tacacgcaga agagcctctc cctgtctccg ggtaaatga 1479 <210>
SEQ ID NO 32 <211> LENGTH: 492 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 32 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala
Ser Ala 130 135 140 Val Gln Leu Gln Gln Ser Gly Pro Glu Ser Glu Lys
Pro Gly Ala Ser 145 150 155 160 Val Lys Ile Ser Cys Lys Ala Ser Gly
Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met Asn Trp Val Lys Gln Asn
Asn Gly Lys Ser Leu Glu Trp Ile Gly 180 185 190 Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Lys Ala
Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 210 215 220 Gln
Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 225 230
235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355
360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 465 470 475
480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 33 <211> LENGTH: 1479 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 33 atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga
taccaccggt 60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt
ctccaggcga aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac
agctacttag cctggtacca acagaaacct 180 ggccaggctc ctaggctcct
catctatttt gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg
gcagtggatc cgggacagac ttcactctca ccatcagcag cctagagcct 300
gaagattttg cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa
360 gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc
tggaggaggt 420 ggagctagcc aggtgcagct ggtggagtct ggtggaggcg
tggtccagcc tgggaggtcc 480 ctgagactct cctgtgcagc ctctggattc
accttcagtg gctacaatat gaactgggtc 540 cgccagatgc ccgggaaagg
cctggagtgg atgggcaata ttgatcctta ttatggtggt 600 actacctaca
accggaagtt caagggccag gtcactatct ccgccgacaa gtccatcagc 660
accgcctacc tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca
720 cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt
ctcctcgagc 780 gagcccaaat cttctgacaa aactcacaca tgcccaccgt
gcccagcacc tgaactcctg 840 ggtggaccgt cagtcttcct cttcccccca
aaacccaagg acaccctcat gatctcccgg 900 acccctgagg tcacatgcgt
ggtggtggac gtgagccacg aagaccctga ggtcaagttc 960 aactggtacg
tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 1020
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat
1080 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat
cgagaaaacc 1140 atctccaaag ccaaagggca gccccgagaa ccacaggtgt
acaccctgcc cccatcccgg 1200 gatgagctga ccaagaacca ggtcagcctg
acctgcctgg tcaaaggctt ctatccaagc 1260 gacatcgccg tggagtggga
gagcaatggg cagccggaga acaactacaa gaccacgcct 1320 cccgtgctgg
actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 1380
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac
1440 tacacgcaga agagcctctc cctgtctccg ggtaaatga 1479 <210>
SEQ ID NO 34 <211> LENGTH: 492 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 34 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala
Ser Gln 130 135 140 Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
Pro Gly Arg Ser 145 150 155 160 Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met
Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val
Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln
Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230
235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val
Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440
445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 485 490 <210> SEQ ID NO 35 <211> LENGTH: 1479
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 35 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggagctagcc aggtgcagct
ggtggagtct ggtggaggcg tggtccagcc tgggaggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tgcccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc
atgaggctct gcacaaccac 1440 tacacgcaga agagcctctc cctgtctccg
ggtaaatga 1479 <210> SEQ ID NO 36 <211> LENGTH: 492
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 36 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Gln 130 135 140 Val Gln Leu Val Glu Ser
Gly Gly Gly Val Val Gln Pro Gly Arg Ser 145 150 155 160 Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Asn 165 170 175 Met
Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185
190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys
195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp
Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser Ser Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro 260 265 270 Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310
315 320 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr 340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435
440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 <210> SEQ ID NO 37 <211> LENGTH: 1476
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 37 atggaagcac cagcgcagct tctcttcctc
ctgctactct ggctcccaga taccaccggt 60 gaaattgtgt tgacacagtc
tccagccacc ctgtctttgt ctccaggcga aagagccacc 120 ctctcctgcc
gaacaagtga aaatgtttac agctacttag cctggtacca acagaaacct 180
ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg aattccagcc
240 aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag
cctagagcct 300 gaagattttg cagtttatta ctgtcaacat cattccgata
atccgtggac attcggccaa 360 gggaccaagg tggaaatcaa aggtggcggt
ggctcgggcg gtggtggatc tggaggaggt 420 ggggctagcg aggtgcagct
ggtggagtct ggtggaggct tggtccagcc tggagggtcc 480 ctgagactct
cctgtgcagc ctctggattc accttcagtg gctacaatat gaactgggtc 540
cgccagatgc ccgggaaagg cctggagtgg atgggcaata ttgatcctta ttatggtggt
600 actacctaca accggaagtt caagggccag gtcactatct ccgccgacaa
gtccatcagc 660 accgcctacc tgcaatggag cagcctgaag gcctcggaca
ccgccatgta ttactgtgca 720 cgctcagtcg gccctatgga ctactggggc
cgcggcaccc tggtcactgt ctcctcgagc 780 gagcccaaat cttctgacaa
aactcacaca tctccaccgt gcccagcacc tgaactcctg 840 ggtggaccgt
cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 900
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc
960 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg
ggaggagcag 1020 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc
tgcaccagga ctggctgaat 1080 ggcaaggagt acaagtgcaa ggtctccaac
aaagccctcc cagcccccat cgagaaaacc 1140 atctccaaag ccaaagggca
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1200 gatgagctga
ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc 1260
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct
1320 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt
ggacaagagc 1380
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac
1440 tacacgcaga agagcctctc cctgtctccg ggtaaa 1476 <210> SEQ
ID NO 38 <211> LENGTH: 492 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 38 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 145
150 155 160 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265
270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val 290 295 300 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390
395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 39
<211> LENGTH: 1476 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 39
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt
60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga
aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac agctacttag
cctggtacca acagaaacct 180 ggccaggctc ctaggctcct catctatttt
gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg gcagtggatc
cgggacagac ttcactctca ccatcagcag cctagagcct 300 gaagattttg
cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa 360
gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc tggaggaggt
420 ggggctagcg aggtgcagct ggtggagtct ggtggaggct tggtccagcc
tggagggtcc 480 ctgagactct cctgtgcagc ctctggattc accttcagtg
gctacaatat gaactgggtc 540 cgccagatgc ccgggaaagg cctggagtgg
atgggcaata ttgatcctta ttatggtggt 600 actacctaca accggaagtt
caagggccag gtcactatct ccgccgacaa gtccatcagc 660 accgcctacc
tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca 720
cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt ctcctcgagc
780 gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc
tgaactcctg 840 ggtggaccgt cagtcttcct cttcccccca aaacccaagg
acaccctcat gatctcccgg 900 acccctgagg tcacatgcgt ggtggtggac
gtgagccacg aagaccctga ggtcaagttc 960 aactggtacg tggacggcgt
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 1020 tacaacagca
cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 1080
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc
1140 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc
cccatcccgg 1200 gatgagctga ccaagaacca ggtcagcctg acctgcctgg
tcaaaggctt ctatccaagc 1260 gacatcgccg tggagtggga gagcaatggg
cagccggaga acaactacaa gaccacgcct 1320 cccgtgctgg actccgacgg
ctccttcttc ctctacagca agctcaccgt ggacaagagc 1380 aggtggcagc
aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1440
tacacgcaga agagcctctc cctgtctccg ggtaaa 1476 <210> SEQ ID NO
40 <211> LENGTH: 492 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 40 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 145
150 155 160 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 260 265
270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val 290 295 300 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390
395 400
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 405
410 415 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro 420 425 430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser 435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 41
<211> LENGTH: 1476 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 41
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt
60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga
aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac agctacttag
cctggtacca acagaaacct 180 ggccaggctc ctaggctcct catctatttt
gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg gcagtggatc
cgggacagac ttcactctca ccatcagcag cctagagcct 300 gaagattttg
cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa 360
gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc tggaggaggt
420 ggggctagcg aggtgcagct ggtggagtct ggtggaggct ctgtccagcc
tggagggtcc 480 ctgagactct cctgtgcagc ctctggattc accttcagtg
gctacaatat gaactgggtc 540 cgccagatgc ccgggaaagg cctggagtgg
atgggcaata ttgatcctta ttatggtggt 600 actacctaca accggaagtt
caagggccag gtcactatct ccgccgacaa gtccatcagc 660 accgcctacc
tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca 720
cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt ctcctcgagc
780 gagcccaaat cttctgacaa aactcacaca tctccaccgt gcccagcacc
tgaactcctg 840 ggtggaccgt cagtcttcct cttcccccca aaacccaagg
acaccctcat gatctcccgg 900 acccctgagg tcacatgcgt ggtggtggac
gtgagccacg aagaccctga ggtcaagttc 960 aactggtacg tggacggcgt
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 1020 tacaacagca
cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 1080
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc
1140 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc
cccatcccgg 1200 gatgagctga ccaagaacca ggtcagcctg acctgcctgg
tcaaaggctt ctatccaagc 1260 gacatcgccg tggagtggga gagcaatggg
cagccggaga acaactacaa gaccacgcct 1320 cccgtgctgg actccgacgg
ctccttcttc ctctacagca agctcaccgt ggacaagagc 1380 aggtggcagc
aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1440
tacacgcaga agagcctctc cctgtctccg ggtaaa 1476 <210> SEQ ID NO
42 <211> LENGTH: 492 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 42 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser 145
150 155 160 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 260 265
270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val 290 295 300 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350 Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380 Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385 390
395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His 465 470 475 480 Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 43
<211> LENGTH: 1476 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 43
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt
60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga
aagagccacc 120 ctctcctgcc gaacaagtga aaatgtttac agctacttag
cctggtacca acagaaacct 180 ggccaggctc ctaggctcct catctatttt
gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg gcagtggatc
cgggacagac ttcactctca ccatcagcag cctagagcct 300 gaagattttg
cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa 360
gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc tggaggaggt
420 ggggctagcg aggtgcagct ggtggagtct ggtggaggct ctgtccagcc
tggagggtcc 480 ctgagactct cctgtgcagc ctctggattc accttcagtg
gctacaatat gaactgggtc 540 cgccagatgc ccgggaaagg cctggagtgg
atgggcaata ttgatcctta ttatggtggt 600 actacctaca accggaagtt
caagggccag gtcactatct ccgccgacaa gtccatcagc 660 accgcctacc
tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca 720
cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt ctcctcgagc
780 gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc
tgaactcctg 840 ggtggaccgt cagtcttcct cttcccccca aaacccaagg
acaccctcat gatctcccgg 900 acccctgagg tcacatgcgt ggtggtggac
gtgagccacg aagaccctga ggtcaagttc 960 aactggtacg tggacggcgt
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 1020 tacaacagca
cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 1080
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc
1140 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc
cccatcccgg 1200 gatgagctga ccaagaacca ggtcagcctg acctgcctgg
tcaaaggctt ctatccaagc 1260 gacatcgccg tggagtggga gagcaatggg
cagccggaga acaactacaa gaccacgcct 1320 cccgtgctgg actccgacgg
ctccttcttc ctctacagca agctcaccgt ggacaagagc 1380 aggtggcagc
aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1440
tacacgcaga agagcctctc cctgtctccg ggtaaa 1476 <210> SEQ ID NO
44 <211> LENGTH: 492 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 44
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5
10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu
Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr
Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr
Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu
Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135
140 Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser
145 150 155 160 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly
Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr
Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala
Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu
Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser
Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255
Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 260
265 270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe 275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val 290 295 300 Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350 Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355 360 365 Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 370 375 380
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 385
390 395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His 465 470 475 480 Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO
45 <211> LENGTH: 1482 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 45
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga
60 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga
aagagccacc 120 ctctcctgcc gagcaagtca aagtgtttac agctacttag
cctggtacca acagaaacct 180 ggccaggctc ctaggctcct catctatttt
gcaaaaacct tagcagaagg aattccagcc 240 aggttcagtg gcagtggatc
cgggacagac ttcactctca ccatcagcag cctagagcct 300 gaagattttg
cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa 360
gggaccaagg tggaaatcaa aggtggcggt ggctcgggcg gtggtggatc tggaggaggt
420 gggaccggtg aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc
cggagagtct 480 ctgaagattt cctgtaaggg atccggttac tcattcactg
gctacaatat gaactgggtg 540 cgccagatgc ccgggaaagg cctcgagtgg
atgggcaata ttgatcctta ttatggtggt 600 actacctaca accggaagtt
caagggccag gtcactatct ccgccgacaa gtccatcagc 660 accgcctacc
tgcaatggag cagcctgaag gcctcggaca ccgccatgta ttactgtgca 720
cgctcagtcg gccctatgga ctactggggc cgcggcaccc tggtcactgt ctcctctgat
780 caggagccca aatcttctga caaaactcac acatctccac cgtgcccagc
acctgaactc 840 ctgggtggac cgtcagtctt cctcttcccc ccaaaaccca
aggacaccct catgatctcc 900 cggacccctg aggtcacatg cgtggtggtg
gacgtgagcc acgaagaccc tgaggtcaag 960 ttcaactggt acgtggacgg
cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1020 cagtacaaca
gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1080
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa
1140 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct
gcccccatcc 1200 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc
tggtcaaagg cttctatcca 1260 agcgacatcg ccgtggagtg ggagagcaat
gggcagccgg agaacaacta caagaccacg 1320 cctcccgtgc tggactccga
cggctccttc ttcctctaca gcaagctcac cgtggacaag 1380 agcaggtggc
agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 1440
cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 1482 <210> SEQ
ID NO 46 <211> LENGTH: 493 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 46 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Gln Ser 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145
150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265
270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390
395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 450 455 460
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465
470 475 480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 47 <211> LENGTH: 1500 <212>
TYPE: DNA <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 47 aagcttgccg ccatggaagc cccagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gagaaattgt
gttgacacag tctccagcca ccctgtcttt gtctccaggc 120 gaaagagcca
ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac 180
caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa
240 ggaattccag ccaggttcag tggcagtgga tccgggacag acttcactct
caccatcagc 300 agcctagagc ctgaagattt tgcagtttat tactgtcaac
atcattccga taatccgtgg 360 acattcggcc aagggaccaa ggtggaaatc
aaaggtggcg gcggctcggg cggtggtgga 420 tctggaggag gtgggaccgg
tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480 cccggagagt
ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat 540
atgaactggg tgcgccagat gcccgggaaa ggcctcgagt ggatgggcaa tattgatcct
600 tattatggtg gtactaccta caaccggaag ttcaagggcc aggtcactat
ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg agcagcctga
aggcctcgga caccgccatg 720 tattactgtg cacgctcagt cggccctttc
gactactggg gccagggcac cctggtcact 780 gtctcctctg atcaggagcc
caaatcttct gacaaaactc acacatctcc accgtgccca 840 gcacctgaac
tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 900
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200 ctgcccccat
cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa 1260
ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
1320 tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta
cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg aacgtcttct
catgctccgt gatgcatgag 1440 gctctgcaca accactacac gcagaagagc
ctctccctgt ctccgggtaa atgatctaga 1500 <210> SEQ ID NO 48
<211> LENGTH: 493 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 48 Met Glu Ala
Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn
35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu
Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala
Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155
160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn
165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn
Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 245 250 255 Val Ser Ser
Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280
285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405
410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 49
<211> LENGTH: 356 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 49 gctagcgagg
tgcagctggt gcagtctgga gcagaggtga aaaagcccgg agagtctctg 60
aagatttcct gtaagggatc cggttactca ttcactggct acaatatgaa ctgggtgcgc
120 cagatgcccg ggaaaggcct ggagtggatg ggcaatattg atccttatta
tggtggtact 180 acctacaacc ggaagttcaa gggccaggtc actatctccg
ccgacaagtc catcagcacc 240 gcctacctgc aatggagcag cctgaaggcc
tcggacaccg ccatgtatta ctgtgcgcgc 300 tcagtcggcc ctatggacgt
ctggggccaa ggcaccactg tcactgtctc ctcgag 356 <210> SEQ ID NO
50 <211> LENGTH: 143 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 50 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly 130 135 140
<210> SEQ ID NO 51 <211> LENGTH: 1381 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 51 aagcttgccg ccatggaagc cccagcgcag cttctcttcc tcctgctact
ctggctccca 60 gataccaccg gagaaattgt gttgacacag tctccagcca
ccctgtcttt gtctccaggc 120 gaaagagcca ccctctcctg ccgagcaagt
gaaaatgttt acagctactt agcctggtac 180 caacagaaac ctggccaggc
tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa 240 ggaattccag
ccaggttcag tggcagtgga tccgggacag acttcactct caccatcagc 300
agcctagagc ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg
360 acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg
cggtggtgga 420
tctggaggag gtgggaccgg tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag
480 cccggagagt ctctgaagat ttcctgtaag ggatccggtt actcattcac
tggctacaat 540 atgaactggg tgcgccagat gcccgggaaa ggcctcgagt
ggatgggcaa tattgatcct 600 tattatggtg gtactaccta caaccggaag
ttcaagggcc aggtcactat ctccgccgac 660 aagtccatca gcaccgccta
cctgcaatgg agcagcctga aggcctcgga caccgccatg 720 tattactgtg
cacgctcagt cggccctttc gactcctggg gccagggcac cctggtcact 780
gtctcctctg atcaggagcc caaatcttct gacaaaactc acacatctcc accgtgccca
840 gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc
caaggacacc 900 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg
tggacgtgag ccacgaagac 960 cctgaggtca agttcaactg gtacgtggac
ggcgtggagg tgcataatgc caagacaaag 1020 ccgcgggagg agcagtacaa
cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1080 caggactggc
tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 1140
cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc
1200 ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg
cctggtcaaa 1260 ggcttctatc caagcgacat cgccgtggag tgggagagca
atgggcagcc ggagaacaac 1320 tacaagacca cgcctcccgt gctggactcc
gacggctcct tcttcctcta cagcaagctc 1380 a 1381 <210> SEQ ID NO
52 <211> LENGTH: 493 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 52 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145
150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly
Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr
Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val
Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 245 250 255 Val
Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265
270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390
395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO
53 <211> LENGTH: 356 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 53
gctagcgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg agagtctctg
60 aagatttcct gtaagggatc cggttactca ttcactggct acaatatgaa
ctgggtgcgc 120 cagatgcccg ggaaaggcct ggagtggatg ggcaatattg
atccttatta tggtggtact 180 acctacaacc ggaagttcaa gggccaggtc
actatctccg ccgacaagtc catcagcacc 240 gcctacctgc aatggagcag
cctgaaggcc tcggacaccg ccatgtatta ctgtgcgcgc 300 tcagtcggcc
cttttgaccc ctggggccaa ggcaccctgg tcactgtctc ctcgag 356 <210>
SEQ ID NO 54 <211> LENGTH: 143 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 54 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr
Gly 130 135 140 <210> SEQ ID NO 55 <211> LENGTH: 356
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 55 gctagcgagg tgcagctggt gcagtctgga
gcagaggtga aaaagcccgg agagtctctg 60 aagatttcct gtaagggatc
cggttactca ttcactggct acaatatgaa ctgggtgcgc 120 cagatgcccg
ggaaaggcct ggagtggatg ggcaatattg atccttatta tggtggtact 180
acctacaacc ggaagttcaa gggccaggtc actatctccg ccgacaagtc catcagcacc
240 gcctacctgc aatggagcag cctgaaggcc tcggacaccg ccatgtatta
ctgtgcgcgc 300 tcagtcggcc cttttcagca ctggggccaa ggcaccctcg
tcactgtctc ctcgag 356 <210> SEQ ID NO 56 <211> LENGTH:
143 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 56 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr
Gly 130 135 140 <210> SEQ ID NO 57 <211> LENGTH: 356
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 57 gctagcgagg tgcagctggt gcagtctgga
gcagaggtga aaaagcccgg agagtctctg 60 aagatttcct gtaagggatc
cggttactca ttcactggct acaatatgaa ctgggtgcgc 120 cagatgcccg
ggaaaggcct ggagtggatg ggcaatattg atccttatta tggtggtact 180
acctacaacc ggaagttcaa gggccaggtc actatctccg ccgacaagtc catcagcacc
240 gcctacctgc aatggagcag cctgaaggcc tcggacaccg ccatgtatta
ctgtgcgcgc 300 tcagtcggcc cttttgacgt ctggggccaa ggcaccatgg
tcactgtctc ctcgag 356 <210> SEQ ID NO 58 <211> LENGTH:
143 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 58 Met Glu Ala Pro Ala Gln Leu Leu
Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60
Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65
70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Thr Gly 130 135 140 <210> SEQ ID NO 59
<211> LENGTH: 356 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 59 gctagcgagg
tgcagctggt gcagtctgga gcagaggtga aaaagcccgg agagtctctg 60
aagatttcct gtaagggatc cggttactca ttcactggct acaatatgaa ctgggtgcgc
120 cagatgcccg ggaaaggcct ggagtggatg ggcaatattg atccttatta
tggtggtact 180 acctacaacc ggaagttcaa gggccaggtc actatctccg
ccgacaagtc catcagcacc 240 gcctacctgc aatggagcag cctgaaggcc
tcggacaccg ccatgtatta ctgtgcgcgc 300 tcagtcggcc cttttgacat
ctggggccaa ggcaccatgg tcactgtctc ctcgag 356 <210> SEQ ID NO
60 <211> LENGTH: 143 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 60 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly 130 135 140
<210> SEQ ID NO 61 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 61 Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala 1 5 10
<210> SEQ ID NO 62 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 62 Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala 1 5 10
<210> SEQ ID NO 63 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 63 Gly Tyr Asn Met Asn 1 5 <210> SEQ ID NO 64
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 64 Phe Ala Lys
Thr Leu Ala Glu 1 5 <210> SEQ ID NO 65 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 65 Asn Ile Asp Pro Tyr Tyr Gly Gly
Thr Thr Tyr Asn Arg Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO
66 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 66 Gln
His His Ser Asp Asn Pro Trp Thr 1 5 <210> SEQ ID NO 67
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 67 Ser Val Gly
Pro Phe Asp Tyr 1 5 <210> SEQ ID NO 68 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 68 Ser Val Gly Pro Phe Asp Ser 1 5
<210> SEQ ID NO 69 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 69 Ser Val Gly Pro Met Asp Tyr 1 5 <210> SEQ ID NO
70 <400> SEQUENCE: 70 000 <210> SEQ ID NO 71
<400> SEQUENCE: 71 000 <210> SEQ ID NO 72 <400>
SEQUENCE: 72 000 <210> SEQ ID NO 73 <400> SEQUENCE: 73
000 <210> SEQ ID NO 74 <400> SEQUENCE: 74 000
<210> SEQ ID NO 75 <400> SEQUENCE: 75 000 <210>
SEQ ID NO 76 <400> SEQUENCE: 76 000 <210> SEQ ID NO 77
<400> SEQUENCE: 77 000 <210> SEQ ID NO 78 <400>
SEQUENCE: 78 000 <210> SEQ ID NO 79 <211> LENGTH: 1500
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 79 aagcttgccg ccatggaagc cccagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gagaaattgt
gttgacacag tctccagcca ccctgtcttt gtctccaggc 120 gaaagagcca
ccctctcctg ccgagcaagt gaaaatgttt acagctactt agcctggtac 180
caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa
240 ggaattccag ccaggttcag tggcagtgga tccgggacag acttcactct
caccatcagc 300 agcctagagc ctgaagattt tgcagtttat tactgtcaac
atcattccga taatccgtgg 360 acattcggcc aagggaccaa ggtggaaatc
aaaggtggcg gtggctcggg cggtggtgga 420 tctggaggag gtgggaccgg
tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480 cccggagagt
ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat 540
atgaactggg tgcgccagat gcccgggaaa ggcctcgagt ggatgggcaa tattgatcct
600 tattatggtg gtactaccta caaccggaag ttcaagggcc aggtcactat
ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg agcagcctga
aggcctcgga caccgccatg 720 tattactgtg cacgctcagt cggccctttc
gacctctggg gcagaggcac cctggtcact 780 gtctcctctg atcaggagcc
caaatcttct gacaaaactc acacatctcc accgtgccca 840 gcacctgaac
tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 900
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200 ctgcccccat
cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa 1260
ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
1320 tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta
cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg aacgtcttct
catgctccgt gatgcatgag 1440 gctctgcaca accactacac gcagaagagc
ctctccctgt ctccgggtaa atgatctaga 1500 <210> SEQ ID NO 80
<211> LENGTH: 493 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 80 Met Glu Ala
Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn
35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu
Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala
Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Glu 130 135 140 Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155
160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn
165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn
Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser
Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280
285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405
410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 81
<211> LENGTH: 1494 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 81
aagcttgccg ccatggaagc cccagctcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gagaaattgt gttgacacag tctccagcca ccctgtcttt
gtctccaggc 120 gaaagagcca ccctctcctg ccgagcaagt gaaaatgttt
acagctactt agcctggtac 180 caacagaaac ctggccaggc tcctaggctc
ctcatctatt ttgcaaaaac cttagcagaa 240 ggaattccag ccaggttcag
tggcagtgga tccgggacag acttcactct caccatcagc 300 agcctagagc
ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg 360
acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg cggtggtgga
420 tctggaggag gtggggctag cgaggtgcag ctggtgcagt ctggagcaga
ggtgaaaaag 480 cccggagagt ctctgaagat ttcctgtaag ggatccggtt
actcattcac tagctacaat 540 atgaactggg tgcgccagat gcccgggaaa
ggcctggagt ggatgggcaa tattgatcct 600 tattatggtg gtactaacta
cgcccagaag ttccagggcc aggtcactat ctccgccgac 660 aagtccatca
gcaccgccta cctgcaatgg agcagcctga aggcctcgga caccgccatg 720
tattactgtg cacgctcagt cggccctatg gactactggg gccgcggcac cctggtcact
780 gtctcctctg atcaggagcc caaatcttct gacaaaactc acacatctcc
accgtgccca 840 gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc
ccccaaaacc caaggacacc 900 ctcatgatct cccggacccc tgaggtcaca
tgcgtggtgg tggacgtgag ccacgaagac 960 cctgaggtca agttcaactg
gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1020 ccgcgggagg
agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1080
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc
1140 cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca
ggtgtacacc 1200 ctgcccccat cccgggatga gctgaccaag aaccaggtca
gcctgacctg cctggtcaaa 1260 ggcttctatc caagcgacat cgccgtggag
tgggagagca atgggcagcc ggagaacaac 1320 tacaagacca cgcctcccgt
gctggactcc gacggctcct tcttcctcta cagcaagctc 1380 accgtggaca
agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag 1440
gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 1494
<210> SEQ ID NO 82 <211> LENGTH: 493 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 82 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala
Ser Glu 130 135 140 Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Glu Ser 145 150 155 160 Leu Lys Ile Ser Cys Lys Gly Ser Gly
Tyr Ser Phe Thr Ser Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met
Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 195 200 205 Gly Gln Val
Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln
Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230
235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val
Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355
360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465 470 475
480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 83 <211> LENGTH: 1476 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 83 aagcttgccg ccatggaagc cccagcgcag cttctcttcc tcctgctact
ctggctccca 60 gataccaccg gagaaattgt gttgacacag tctccagcca
ccctgtcttt gtctccaggc 120 gaaagagcca ccctctcctg ccgagcaagt
gagaatgttt acagctactt agcctggtac 180 caacagaaac ctggccaggc
tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa 240 gggattccag
ccagattcag tggcagtggt tccgggacag acttcactct caccatcagc 300
agcctagagc ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg
360 acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg
cggtggtgga 420 tctggaggag gtgggagcgg aggaggagct agcgaggtgc
agctggtgca gtctggagca 480 gaggtgaaaa agcccggaga gtctctgaag
atttcctgta agggatccgg ttactcattc 540 actggctaca atatgaactg
ggtgcgccag atgcccggga aaggcctcga atggatgggc 600 aatattgatc
cttattatgg tggtactacc tacaaccgga agttcaaggg ccaggtcact 660
atctccgccg acaagtccat cagcaccgcc tacctgcaag gagcagcctg aaggcctcgg
720 acaccgccat gtattactgt gcacgctcag tcggcccttt cgactcctgg
ggccagggca 780 ccctggtcac tgtctcgagt tgtccaccgt gcccagcacc
tgaactcctg ggtggaccgt 840 cagtcttcct cttcccccca aaacccaagg
acaccctcat gatctcccgg acccctgagg 900 tcacatgcgt ggtggtggac
gtgagccacg aagaccctga ggtcaagttc aactggtacg 960 tggacggcgt
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca 1020
cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt
1080 acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc
atctccaaag 1140 ccaaagggca gccccgagaa ccacaggtgt acaccctgcc
cccatcccgg gatgagctga 1200 ccaagaacca ggtcagcctg acctgcctgg
tcaaaggctt ctatccaagc gacatcgccg 1260 tggagtggga gagcaatggg
cagccggaga acaactacaa gaccacgcct cccgtgctgg 1320 actccgacgg
ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc 1380
aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga
1440 agagcctctc cctgtctccg ggtaaatgac tctaga 1476 <210> SEQ
ID NO 84 <211> LENGTH: 485 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 84 Met
Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10
15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu
Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 130 135 140
Gly Ala Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 145
150 155 160 Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr
Ser Phe 165 170 175 Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro
Gly Lys Gly Leu 180 185 190 Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr
Gly Gly Thr Thr Tyr Asn 195 200 205 Arg Lys Phe Lys Gly Gln Val Thr
Ile Ser Ala Asp Lys Ser Ile Ser 210 215 220 Thr Ala Tyr Leu Gln Trp
Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 225 230 235 240 Tyr Tyr Cys
Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly 245 250 255 Thr
Leu Val Thr Val Ser Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu 260 265
270 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr
275 280 285 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val 290 295 300 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val 305 310 315 320 Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser 325 330 335 Thr Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu 340 345 350 Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 355 360 365 Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 370 375 380 Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 385 390
395 400 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala 405 410 415 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr 420 425 430 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu 435 440 445 Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser 450 455 460 Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser 465 470 475 480 Leu Ser Pro Gly
Lys 485 <210> SEQ ID NO 85 <211> LENGTH: 1494
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 85 aagcttgccg ccatggaagc cccagctcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gagaaattgt
gttgacacag tctccagcca ccctgtcttt gtctccaggc 120 gaaagagcca
ccctctcctg ccgaacaagt gaaaatgttt acagctactt agcctggtac 180
caacagaaac ctggccaggc tcctaggctc ctcatctatt ttgcaaaaac cttagcagaa
240 ggaattccag ccaggttcag tggcagtgga tccgggacag acttcactct
caccatcagc 300 agcctagagc ctgaagattt tgcagtttat tactgtcaac
atcattccga taatccgtgg 360 acattcggcc aagggaccaa ggtggaaatc
aaaggtggcg gtggctcggg cggtggtgga 420 tctggaggag gtgggaccgg
tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag 480 cccggagagt
ctctgaagat ttcctgtaag ggatccggtt actcattcac tggctacaat 540
atgaactggg tgcgccagat gcccgggaaa ggcctggagt ggatgggcaa tattgatcct
600 tattatggtg gtactaccta caaccggaag ttcaagggcc aggtcactat
ctccgccgac 660 aagtccatca gcaccgccta cctgcaatgg agcagcctga
aggcctcgga caccgccatg 720 tattactgtg cacgctcagt cggccctatg
gactactggg gccgcggcac cctggtcact 780 gtctcctctg atcaggagcc
caaatcttct gacaaaactc acacatctcc accgtgccca 840 gcacctgaac
tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 900
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
960 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 1020 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 1080 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 1140 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 1200 ctgcccccat
cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa 1260
ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
1320 tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta
cagcaagctc 1380 accgtggaca agagcaggtg gcagcagggg aacgtcttct
catgctccgt gatgcatgag 1440 gctctgcaca accactacac gcagaagagc
ctctccctgt ctccgggtaa atga 1494 <210> SEQ ID NO 86
<211> LENGTH: 493 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 86 Met Glu Ala
Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asn
35 40 45 Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Phe Ala Lys Thr Leu Ala Glu
Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala
Val Tyr Tyr Cys Gln His His Ser 100 105 110 Asp Asn Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 115 120 125 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Glu 130 135 140 Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 145 150 155
160 Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr Asn
165 170 175 Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met Gly 180 185 190 Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn
Arg Lys Phe Lys 195 200 205 Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr Leu 210 215 220 Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys Ala 225 230 235 240 Arg Ser Val Gly Pro
Met Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr 245 250 255 Val Ser Ser
Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 260 265 270 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 275 280
285 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
290 295 300 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 305 310 315 320 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 325 330 335 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 340 345 350 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355 360 365 Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 370 375 380 Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 385 390 395 400
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 405
410 415 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 420 425 430 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 435 440 445 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln 450 455 460 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn 465 470 475 480 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 <210> SEQ ID NO 87
<211> LENGTH: 1494 <212> TYPE: DNA <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 87
aagcttgccg ccatggaagc cccagctcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gtgaaattgt gttgacacag tctccagcca ccctgtcttt
gtctccaggc 120 gaaagagcca ccctctcctg ccgaacaagt gaaaatgttt
acagctactt agcctggtac 180 caacagaaac ctggccaggc tcctaggctc
ctcatctatt ttgcaaaaac cttagcagaa 240 ggaattccag ccaggttcag
tggcagtgga tccgggacag acttcactct caccatcagc 300 agcctagagc
ctgaagattt tgcagtttat tactgtcaac atcattccga taatccgtgg 360
acattcggcc aagggaccaa ggtggaaatc aaaggtggcg gtggctcggg cggtggtgga
420 tctggaggag gtggggctag cgaggtgcag ctggtgcagt ctggagcaga
ggtgaaaaag 480 cccggagagt ctctgaggat ttcctgtaag ggatccggtt
actcattcac tggctacaat 540 atgaactggg tgcgccagat gcccgggaaa
ggcctggagt ggatgggcaa tattgatcct 600 tattatggtg gtactaccta
caaccggaag ttcaagggcc aggtcactat ctccgccgac 660 aagtccatca
gcaccgccta cctgcaatgg agcagcctga aggcctcgga caccgccatg 720
tattactgtg cacgctcagt cggccctatg gactactggg gccgcggcac cctggtcact
780 gtctcctctg atcaggagcc caaatcttct gacaaaactc acacatctcc
accgtgccca 840 gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc
ccccaaaacc caaggacacc 900 ctcatgatct cccggacccc tgaggtcaca
tgcgtggtgg tggacgtgag ccacgaagac 960 cctgaggtca agttcaactg
gtacgtggac ggcgtggagg tgcataatgc caagacaaag 1020 ccgcgggagg
agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 1080
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc
1140
cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc
1200 ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg
cctggtcaaa 1260 ggcttctatc caagcgacat cgccgtggag tgggagagca
atgggcagcc ggagaacaac 1320 tacaagacca cgcctcccgt gctggactcc
gacggctcct tcttcctcta cagcaagctc 1380 accgtggaca agagcaggtg
gcagcagggg aacgtcttct catgctccgt gatgcatgag 1440 gctctgcaca
accactacac gcagaagagc ctctccctgt ctccgggtaa atga 1494 <210>
SEQ ID NO 88 <211> LENGTH: 493 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 88 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu
Ser Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr
Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala
Ser Glu 130 135 140 Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Glu Ser 145 150 155 160 Leu Arg Ile Ser Cys Lys Gly Ser Gly
Tyr Ser Phe Thr Gly Tyr Asn 165 170 175 Met Asn Trp Val Arg Gln Met
Pro Gly Lys Gly Leu Glu Trp Met Gly 180 185 190 Asn Ile Asp Pro Tyr
Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 195 200 205 Gly Gln Val
Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 210 215 220 Gln
Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 225 230
235 240 Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Arg Gly Thr Leu Val
Thr 245 250 255 Val Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser 260 265 270 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu 275 280 285 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 290 295 300 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 305 310 315 320 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 325 330 335 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 340 345 350
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 355
360 365 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 370 375 380 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 385 390 395 400 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 405 410 415 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 420 425 430 Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 435 440 445 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 450 455 460 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 465 470 475
480 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 89 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 89 gagcccaaat cttgtgacaa aactcacaca tgtccaccgt gccca 45
<210> SEQ ID NO 90 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 90 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 91 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 91 gagcccaaat cttctgacaa aactcacaca
tgtccaccgt gccca 45 <210> SEQ ID NO 92 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 92 Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> SEQ ID NO 93
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 93 gagcccaaat
cttctgacaa aactcacaca tgtccaccgt gctca 45 <210> SEQ ID NO 94
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 94 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 95 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 95 gagcccaaat cttgtgacaa aactcacaca tgtccaccga gctca 45
<210> SEQ ID NO 96 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 96 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 97 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 97 gagcccaaat cttctgacaa aactcacaca
tctccaccga gccca 45 <210> SEQ ID NO 98 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 98 Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser Pro Pro Ser Pro 1 5 10 15 <210> SEQ ID NO 99
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 99
gagcccaaat cttctgacaa aactcacaca tctccaccga gctca 45 <210>
SEQ ID NO 100 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 100 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 101 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 101 gagcccaaat cttgtgacaa aactcacaca
tctccaccgt gccca 45 <210> SEQ ID NO 102 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 102 Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Ser Pro Pro Cys Pro 1 5 10 15 <210> SEQ ID NO 103
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 103 gagcccaaat
cttgtgacaa aactcacaca tctccaccgt gctca 45 <210> SEQ ID NO 104
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 104 Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 105 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 105 gagcccaaat cttctgacaa aactcacaca tctccaccgt gccca 45
<210> SEQ ID NO 106 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 106 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 107 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 107 gagcccaaat cttctgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 108 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 108 Glu Pro Lys Ser Ser Asp Lys Thr
His Thr Ser Pro Pro Cys Ser 1 5 10 15 <210> SEQ ID NO 109
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 109 gagcccaaat
cttgtgacaa aactcacaca tctccaccga gccca 45 <210> SEQ ID NO 110
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 110 Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 1 5 10 15
<210> SEQ ID NO 111 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 111 gagcccaaat cttgtgacaa aactcacaca tctccaccga gctca 45
<210> SEQ ID NO 112 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 112 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 113 <400> SEQUENCE:
113 000 <210> SEQ ID NO 114 <400> SEQUENCE: 114 000
<210> SEQ ID NO 115 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 115 Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro
Pro Thr Pro 1 5 10 15 Ser Pro Ser <210> SEQ ID NO 116
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 116 Val Pro
Pro Pro Pro Pro 1 5 <210> SEQ ID NO 117 <211> LENGTH:
186 <212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 117 gagctcaaaa ctcctctcgg ggatacgacc
catacgtgtc cccgctgtcc tgaaccgaag 60 tcctgcgata cgcctccgcc
atgtccacgg tgcccagagc ccaaatcatg cgatacgccc 120 ccaccgtgtc
cccgctgtcc tgaaccaaag tcatgcgata ccccaccacc atgtccaaga 180 tgccca
186 <210> SEQ ID NO 118 <211> LENGTH: 62 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 118 Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr
His Thr Cys Pro Arg Cys 1 5 10 15 Pro Glu Pro Lys Ser Cys Asp Thr
Pro Pro Pro Cys Pro Arg Cys Pro 20 25 30 Glu Pro Lys Ser Cys Asp
Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 35 40 45 Pro Lys Ser Cys
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 50 55 60 <210> SEQ ID
NO 119 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 119 gagcccaaat cttctgacac acctccccca tgcccacggt gcccc 45
<210> SEQ ID NO 120 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 120 Glu Pro Lys Ser Ser Asp Thr Pro Pro Pro Cys Pro Arg
Cys Pro 1 5 10 15 <210> SEQ ID NO 121 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 121 gagcccaaat cttgtgacac acctccccca
tccccacggt cccca 45 <210> SEQ ID NO 122 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 122 Glu Pro Lys Ser Cys Asp Thr Pro
Pro Pro Ser Pro Arg Ser Pro 1 5 10 15 <210> SEQ ID NO 123
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 123 gagcccaaat
cttctgacac acctccccca tccccacggt cccca 45 <210> SEQ ID NO 124
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 124 Glu Pro
Lys Ser Ser Asp Thr Pro Pro Pro Ser Pro Arg Ser Pro 1 5 10 15
<210> SEQ ID NO 125 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 125 gagcccaaat cttgtgacac acctccccca tccccacggt gccca 45
<210> SEQ ID NO 126 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 126 Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Ser Pro Arg
Cys Pro 1 5 10 15 <210> SEQ ID NO 127 <211> LENGTH: 58
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 127 Glu Ser Pro Lys Ala Gln Ala Ser
Ser Val Pro Thr Ala Gln Pro Gln 1 5 10 15 Ala Glu Gly Ser Leu Ala
Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 20 25 30 Asn Thr Gly Arg
Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 35 40 45 Glu Gln
Glu Glu Arg Glu Thr Lys Thr Pro 50 55 <210> SEQ ID NO 128
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 128 Arg Thr
Ser Gln Asn Val Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID NO
129 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 129 Arg
Thr Ser Glu Ser Val Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID
NO 130 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 130 Arg
Ala Ser Gln Ser Val Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID
NO 131 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 131 Arg
Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> SEQ ID
NO 132 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 132 Arg
Ala Ser Gln Ser Val Ser Tyr Tyr Leu Ala 1 5 10 <210> SEQ ID
NO 133 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 133 Ser
Tyr Met Asn Met 1 5 <210> SEQ ID NO 134 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 134 Ser Tyr Trp Ile Gly 1 5
<210> SEQ ID NO 135 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 135 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> SEQ ID NO
136 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 136 Gly
Ala Ser Thr Arg Ala Thr 1 5 <210> SEQ ID NO 137 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 137 Asp Ala Ser Asn Arg Ala
Thr 1 5 <210> SEQ ID NO 138 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 138 Ile Ile Tyr Pro Gly Asp Ser Asp
Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> SEQ ID NO
139 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 139 Arg
Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Gln 1 5 10
15 Gly <210> SEQ ID NO 140 <211> LENGTH: 30 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr 20 25 30 <210> SEQ ID NO 141
<211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 141 Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 20 25 30
<210> SEQ ID NO 142 <400> SEQUENCE: 142 000 <210>
SEQ ID NO 143 <211> LENGTH: 30 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 143 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro Gly Ala 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr
Thr Phe Thr 20 25 30 <210> SEQ ID NO 144 <211> LENGTH:
30 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 144 Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys
Lys Gly Ser Gly Tyr Ser Phe Thr 20 25 30 <210> SEQ ID NO 145
<211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 145 Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15
Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 20 25 30
<210> SEQ ID NO 146 <211> LENGTH: 30 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 146 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr 20 25 30 <210> SEQ ID NO 147 <211> LENGTH:
14 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 147 Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu Trp Met Gly 1 5 10 <210> SEQ ID NO 148
<400> SEQUENCE: 148 000 <210> SEQ ID NO 149 <400>
SEQUENCE: 149 000 <210> SEQ ID NO 150 <211> LENGTH: 14
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 150 Trp Val Gln Gln Ala Pro Gly Lys
Gly Leu Glu Trp Met Gly 1 5 10 <210> SEQ ID NO 151
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 151 Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 1 5 10 <210>
SEQ ID NO 152 <400> SEQUENCE: 152 000 <210> SEQ ID NO
153 <400> SEQUENCE: 153 000 <210> SEQ ID NO 154
<211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 154 Arg Val
Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 1 5 10 15
Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20
25 30 <210> SEQ ID NO 155 <211> LENGTH: 32 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 155 Arg Val Thr Ile Thr Ala Asp Glu Ser Thr
Ser Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp
Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 156
<211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 156 Arg Val
Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 1 5 10 15
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20
25 30 <210> SEQ ID NO 157 <211> LENGTH: 32 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 157 Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala
Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Thr 20 25 30 <210> SEQ ID NO 158 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 158 Gln Val Thr Ile Ser Ala
Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 1 5 10 15 Trp Ser Ser Leu
Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 20 25 30
<210> SEQ ID NO 159 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 159 His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala
Tyr Leu Gln 1 5 10 15 Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 160 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 160 Arg Phe Val Phe Ser Leu
Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 1 5 10 15 Ile Ser Ser Leu
Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30
<210> SEQ ID NO 161 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 161 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10
<210> SEQ ID NO 162 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 162 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 1 5 10
<210> SEQ ID NO 163 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 163 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 1 5 10
<210> SEQ ID NO 164 <400> SEQUENCE: 164 000 <210>
SEQ ID NO 165 <400> SEQUENCE: 165 000 <210> SEQ ID NO
166 <400> SEQUENCE: 166 000 <210> SEQ ID NO 167
<400> SEQUENCE: 167 000 <210> SEQ ID NO 168 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 168 Trp Gly Gln Gly Thr Thr
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 169 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 169 Trp Gly Lys Gly Thr Thr
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 170 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 170 Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys 20 <210> SEQ ID NO 171 <211> LENGTH: 23
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 171 Glu Ile Val Leu Thr Gln Ser Pro
Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser
Cys 20 <210> SEQ ID NO 172 <211> LENGTH: 23 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 172 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20
<210> SEQ ID NO 173 <400> SEQUENCE: 173 000 <210>
SEQ ID NO 174 <400> SEQUENCE: 174 000 <210> SEQ ID NO
175 <211> LENGTH: 23 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 175 Asn
Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 1 5 10
15 Asp Arg Val Thr Ile Thr Cys 20 <210> SEQ ID NO 176
<400> SEQUENCE: 176 000 <210> SEQ ID NO 177 <211>
LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 177 Ala Ile Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr
Ile Thr Cys 20
<210> SEQ ID NO 178 <211> LENGTH: 23 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 178 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 179 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 179 Ala Ile Arg Met Thr Gln Ser Pro Phe Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 180 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 180 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 181 <211> LENGTH: 23 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 181 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210>
SEQ ID NO 182 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 182 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
Ile Tyr 1 5 10 15 <210> SEQ ID NO 183 <400> SEQUENCE:
183 000 <210> SEQ ID NO 184 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 184 Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> SEQ ID NO 185
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 185 Trp Tyr
Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 186 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 186 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu
Ile Tyr 1 5 10 15 <210> SEQ ID NO 187 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 187 Trp Phe Gln Gln Lys Pro Gly Lys
Val Pro Lys His Leu Ile Tyr 1 5 10 15 <210> SEQ ID NO 188
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Humanized TRU-016 <400> SEQUENCE: 188 Trp Phe
Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 189 <400> SEQUENCE: 189 000 <210>
SEQ ID NO 190 <400> SEQUENCE: 190 000 <210> SEQ ID NO
191 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 191 Trp
Tyr Gln Gln Lys Pro Ala Lys Ala Pro Lys Leu Phe Ile Tyr 1 5 10 15
<210> SEQ ID NO 192 <400> SEQUENCE: 192 000 <210>
SEQ ID NO 193 <400> SEQUENCE: 193 000 <210> SEQ ID NO
194 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 194 Gly
Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 1 5 10
15 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys
20 25 30 <210> SEQ ID NO 195 <211> LENGTH: 32
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 195 Gly Ile Pro Ala Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 20 25 30 <210> SEQ ID
NO 196 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 196 Gly
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10
15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
20 25 30 <210> SEQ ID NO 197 <211> LENGTH: 32
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 197 Gly Val Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 20
25 30 <210> SEQ ID NO 198 <211> LENGTH: 32 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 198 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Glu Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> SEQ ID NO 199
<400> SEQUENCE: 199 000 <210> SEQ ID NO 200 <400>
SEQUENCE: 200 000 <210> SEQ ID NO 201 <400> SEQUENCE:
201 000 <210> SEQ ID NO 202 <400> SEQUENCE: 202 000
<210> SEQ ID NO 203 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 203 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Tyr Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
Ala Thr Tyr Tyr Cys 20 25 30 <210> SEQ ID NO 204 <400>
SEQUENCE: 204 000 <210> SEQ ID NO 205 <211> LENGTH: 32
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Humanized
TRU-016 <400> SEQUENCE: 205 Gly Val Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Thr Glu Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu
Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> SEQ ID
NO 206 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 206 Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> SEQ ID NO
207 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 207 Phe
Gly Gln Gly Thr Lys Leu Glu Ile Lys 1 5 10 <210> SEQ ID NO
208 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 208 Phe
Gly Pro Gly Thr Lys Val Asp Ile Lys 1 5 10 <210> SEQ ID NO
209 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 209 Phe
Gly Gly Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> SEQ ID NO
210 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 210 Phe
Gly Gln Gly Thr Arg Leu Glu Ile Lys 1 5 10 <210> SEQ ID NO
211 <400> SEQUENCE: 211 000 <210> SEQ ID NO 212
<400> SEQUENCE: 212 000 <210> SEQ ID NO 213 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 213 Ser Val Gly Pro Met Asp
Val 1 5 <210> SEQ ID NO 214 <400> SEQUENCE: 214 000
<210> SEQ ID NO 215 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 215 Ser Val Gly Pro Phe Asp Pro 1 5 <210> SEQ ID NO
216 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Humanized TRU-016 <400> SEQUENCE: 216 Ser
Val Gly Pro Phe Gln His 1 5 <210> SEQ ID NO 217 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Humanized TRU-016 <400> SEQUENCE: 217 Ser Val Gly Pro Phe Asp
Val 1 5 <210> SEQ ID NO 218 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Humanized TRU-016
<400> SEQUENCE: 218 Ser Val Gly Pro Phe Asp Ile 1 5
<210> SEQ ID NO 219 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Humanized TRU-016 <400>
SEQUENCE: 219 Ser Val Gly Pro Phe Asp Leu 1 5
<210> SEQ ID NO 220 <400> SEQUENCE: 220 000 <210>
SEQ ID NO 221 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Linker peptide <400> SEQUENCE:
221 Gly Gly Gly Gly Ser 1 5 <210> SEQ ID NO 222 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Linker
peptide <400> SEQUENCE: 222 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 1 5 10 <210> SEQ ID NO 223 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Linker peptide
<400> SEQUENCE: 223 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 224 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Linker
peptide <400> SEQUENCE: 224 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20
<210> SEQ ID NO 225 <211> LENGTH: 25 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Linker peptide <400> SEQUENCE:
225 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 <210> SEQ
ID NO 226 <211> LENGTH: 30 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Linker peptide <400> SEQUENCE: 226 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25
30
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.