Compounds, Compositions, Methods Of Synthesis, And Methods Of Treatment

Abstract

The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF.sub.1) receptor ligand compounds and compositions, as well as methods of preparation and treatment.

Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims priority to U.S. provisional application entitled "COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT," having Ser. No. 61/154,146, filed on Feb. 20, 2009, which is entirely incorporated herein by reference.

TECHNICAL FIELD

[0002] The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF.sub.1) receptor ligand compounds and compositions, as well as methods of preparation and treatment.

BACKGROUND

[0003] Corticotropin releasing factor (CRF) is a peptide comprised of 41 amino acids. Vale et al. Science (1981) 213:1394. It is secreted by the hypothalamus, serving to coordinate the neuroendocrine response to stress by the hypothalamic-pituitary-adrenal (HPA) axis. Dunn et al. Brain Res. Rev. (1990) 15:71. As well as its role at the pituitary gland, CRF has demonstrated broad extrahypothalamic distribution in the central nervous system, producing a wide variety of autonomic, electrophysiological, and behavioral effects consistent with a neurotransmitter or neuromodulator role in the brain. Vale et al. Rec. Prog. Horm. Res. (1981) 39:245; Koob et al. Persp. Behay. Med. (1985) 2:39. De Souza (1985) 5:3189. CRF has been implicated in the pathophysiology of depression and other affective disorders which, in turn, has led to research of CRF.sub.1 antagonists. Arborelius et al. J. Endocrinol. (1999) 160:1; Kasckow et al. Peptides (2001) 22:845; Nemeroff et al. Science (1984) 226:1342; Gilligan et al. J. Med. Chem. (2000) 43:1641; Grigoriadis et al. Curr. Med. Chem.--CNS Agents (2001) 1:63; Owens et al. CNS Drugs (1999) 12:85; Keck et al. Peptides (2001) 22:835; Arzt et al. Trends Pharmacol. Sci. (2006) 27:531.

[0004] Administration of CRF directly to the brain elicits behavioral, physiological, and endocrine responses identical to those observed for an animal exposed to a stressful environment. Accordingly, clinical data suggests that CRF receptor antagonists may be useful in the treatment of the neuropsychiatric disorders manifesting hypersecretion of CRF, and, in particular, may represent novel antidepressant and/or anxiolytic drugs. The first CRF receptor antagonists were peptides. U.S. Pat. No. 4,605,642; Rivier et al., Science (1984) 224:889. While these peptides established that CRF receptor antagonists can attenuate the pharmacological responses to CRF, peptide CRF receptor antagonists suffer from the usual drawbacks of peptide therapeutics including lack of stability and limited oral activity. More recently, small molecule CRF receptor antagonists have been reported. Because of the physiological significance of CRF, biologically-active, small molecules having significant CRF receptor binding activity are thought to be useful in the treatment of endocrine, psychiatric and neurologic conditions or illnesses, including stress-related disorders in general.

[0005] In fact, CRF has been implicated in a variety of diseases to date, as indicated by the following publications. It was reported that elevated concentrations of CRF in the cerebrospinal fluid of patients with major depression compared with healthy individuals; CRF-mRNA levels in the hypothalamus of depressive patients are higher than that of healthy individuals; and CRF receptors in cerebral cortex are reduced in suicide victims; plasma ACTH increase is diminished with administration of CRF to depressive patients. Journal of Endocrinology (1999) 160:1. CRF levels in the cerebrospinal fluid of some anxiety patients with obsessive-compulsive disorder, posttraumatic stress disorder or Tourette's syndrome are higher than in that of healthy individuals. Journal of Endocrinology (1999) 160:1. Plasma ACTH increase is diminished with administration of CRF to panic disorder patients. Exp. Clin. Endcrinol. Diabetes (1997) 105:65. Anxiety behavior has been observed in experimental animals by intracerebral administration of CRF. In addition, anxiety behavior is observed more frequently in CRF overexpressing mice than in normal mice. Journal of Endocrinology (1999) 160:1. CRF levels in the locus coeruleus are reduced by administration of anxiolytics. Exp. Clin. Endocrinol. Diabetes (1997) 105:65. Also, .alpha.-helical CRF(9-41), a peptide CRF antagonist, exhibits an antianxiety action in animal models. Brain Res. (1990) 509:80; Regulatory Peptides (1987) 18:37; J. Neurosci. (1994) 14:2579. Abnormal behavior withdrawal from alcohol or addictive drugs such as cocaine are inhibited by .alpha.-helical CRF(9-41), a peptide CRF antagonist Psychopharmacology (1991) 103:227.

[0006] CRF inhibits sexual behavior in rats. Nature (1983) 305:232. CRF reduces sleep in rats and is thus implicated the involvement in sleep disorder. Pharmacol. Biochem. Behay. (1987) 26:699. .alpha.-helical CRF(9-41), a peptide CRF antagonist, suppresses brain damage or electroencephalogram disturbances due to brain ischemia or NMDA receptor activation. TIPS (1996) 17:166. CRF elicits electroencephalogram and induces convulsions. Brain Res. (1983) 278:332. Cerebrospinal CRF levels are elevated in schizophrenic patients compared with healthy individuals. Am. J. Psychiatry (1987) 144:873. CRF content in the cerebral cortex is reduced in Alzheimer's disease patients, Parkinson's disease patients and progressive supranuclear palsy patients. Neurology (1987) 37, 905. CRF is reduced in the ganglia in Huntington's disease Neurology (1987) 37:905; Brain Res. (1987) 437:355. In addition, CRF administration has been found to enhance learning and memory in rats. Exp. Clin. Endcrinol. Diabetes (1997) 105:65.

[0007] CRF content in cerebrospinal fluid are reduced in amyotrophic lateral sclerosis patients. Oversecretion of ACTH and adrenocorticosteroids are exhibited in mice overexpressing CRF, these mice display abnormalities similar to Cushing's syndrome, including muscular atrophy, alopecia, and infertility. Endocrinology (1992) 130:3378. Cerebrospinal CRF is elevated in anorexia nervosa patients compared with healthy individuals, and plasma ACTH increase is low with administration of CRF to anorexia nervosa patients; and CRF suppress feeding in experimental animals. TIPS (1996) 17:166. Moreover, .alpha.-helical CRF(9-41), a peptide CRF antagonist, improves stress-induced hypophagia in animal models. Brain Res. Bull. (1986) 17:285. CRF has suppressed body weight gain in hereditary obese animals; a link has been suggested between low CRF levels and obesity syndrome; and the anorexic action and the body weight loss action of serotonin reuptake inhibitors has been possibly mediated by CRF release TIPS (1996) 17:166.

[0008] CRF acts centrally or peripherally to weaken gastric contraction and reduce gastric emptying Annals of the New York Academy of Sciences (1993) 697:233. Furthermore, reduced gastric function induced by abdominal surgery is recovered by .alpha.-helical CRF(9-41), a peptide CRF antagonist Am. J. Physiol. (1992) 262:G616. CRF promotes secretion of bicarbonate ion in the stomach, thereby lowering gastric acid secretion and suppressing cold restraint stress ulcers. Am. J. Physiol. (1990) 258:G152. Also, administration of CRF increases ulcers in non-restraint stress animals. Life Sci. (1989) 45:907. CRF suppresses small intestinal transit and promotes large intestinal transit, and defecation is induced. In addition, .alpha.-helical CRF(9-41), a peptide CRF antagonist, has a inhibiting action against restraint stress-induced gastric acid secretion, reduced gastric emptying, reduced small intestinal transit and promoted large intestinal transit. Gastroenterology (1988) 95:1510. Psychological stress in healthy individuals increases anxiety or sensations of gas and abdominal pain during colonic distension and CRF lowers the discomfort threshold. Gastroenterol. (1995) 109:1772; Neurogastroenterol. Mot. (1996) 8:9. Irritable bowel syndrome patients experience excessive acceleration of colonic motility with CRF administration compared to healthy individuals Gut (1998) 42:845.

[0009] Administration of CRF increases blood pressure, heart rate and body temperature, while .alpha.-helical CRF(9-41), a peptide CRF antagonist, suppresses stress-induced increases in blood pressure, heart rate and body temperature. J. Physiol. (1993) 460:221. CRF production is increased locally in inflammation sites in experimental animals and in the synovial fluid of rheumatic arthritis patients TIPS (1996) 17:166. CRF provokes degranulation of mast cells and promotes vascular permeability Endocrinology (1998) 139:403. CRF is detected in autoimmune thyroiditis patients Am. J. Pathol. (1994) 145:1159. Administration of CRF to experimental autoimmune encephalomyelitis rats has notably suppressed progression of symptoms such as paralysis. J. Immunol. (1997) 158:5751. Urocortin (a CRF analogue) has increased growth hormone secretion in a pituitary adenoma culture system from an acromegalia patient. Endocri. J. (1997) 44:627. Furthermore, CRF simulates secretion of cytokines such as interleukin-1 and interleukin-2 by leukocytes. J. Neuroimmunol. (1989) 23:256; Neurosci. Lett. (1990) 120:151. CRF administration and stress both suppress T lymphocyte proliferation and natural killer cell activity. .alpha.-helical CRF(9-41), a peptide CRF antagonist, improves the reduced function of these immune cells caused by CRF administration or stress. Endocrinology (1991) 128:1329. Breathing is notably increased by administration of CRF. Eur. J. Pharmacol. (1990) 182:405. Finally, aggravated breathing and insomnia have been observed as a result of CRF administration to elderly patients under chronic artificial respiration Acta Endocrinol. Copenh (1992) 127:200.

[0010] Thus, there is a need in the art for CRF antagonists.

SUMMARY

[0011] Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF.sub.1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF.sub.1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

[0012] One exemplary compound among others, includes: a compound selected from the group consisting of:

##STR00001##

as well as an atropisomer of each of these, a racemic mixture of each of these, and a stereoisomer of each of these, and a pharmaceutically acceptable salt of any of the foregoing, wherein: [0013] R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl,

[0013] ##STR00002## [0014] R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl; [0015] each R.sup.3 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, --NO.sub.2, --NH, --NH-alkyl, --N(alkyl).sub.2, --N(alkyl).sub.3OTf, --N(alkyl).sub.3X, --Sn(alkyl).sub.3, --SH, --S-alkyl, and --S-haloalkyl, wherein n is 1, 2, or 3 and wherein if n is 2 or 3, each R.sup.3 is chosen independently of any other R.sup.3; [0016] each of R.sup.4, R.sup.5, and R.sup.6 (R.sup.5 and R.sup.6 are shown below) are each independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, and --Sn(alkyl).sub.3, wherein o, p, and q are each independently 1, 2, or 3 and wherein if any of o, p, or q are 2 or 3, each of R.sup.4, R.sup.5, and R.sup.6 are chosen independently of each other and any other R.sup.4, R.sup.5, and R.sup.6; [0017] R.sup.7 is selected from the group consisting of: --H and alkyl; [0018] R.sup.9 is selected from the group consisting of: --H, alkyl, alkenyl, benzyl, haloalkyl, haloalkenyl, and

[0018] ##STR00003## [0019] each R.sup.9 are independently selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl, each R.sup.9 is chosen independently of any other R.sup.9; [0020] R.sup.10 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl; [0021] R.sup.11 is selected from the group consisting of:

[0021] ##STR00004## [0022] R.sup.12 is selected from the group consisting of: --H, --OH, --O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; [0023] R.sup.13 is selected from the group consisting of: --H, alkyl, haloalkyl, and heteroalkyl; [0024] R.sup.14 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl; [0025] R.sup.15 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl; [0026] X is a halogen [0027] X.sup.2 is selected from the group consisting of: --H, alkyl, --X, and --Sn(alkyl).sub.3; [0028] y is selected from the group consisting of: 1 or 2; and [0029] z is selected from the group consisting of: 1, 2, or 3;

[0030] with the proviso that for formula (I), when R.sup.11 is

##STR00005##

R.sup.1 is butyl and R.sup.2 is ethyl, R.sup.3 is not: 2-Br-4-i-Pr; 2,4-Cl; 2,4,6-CH.sub.3; 2-Cl-4-OCH.sub.3; or 2-CH.sub.3-4-OCH.sub.3.

[0031] One exemplary compound, among others, includes: a labeled compound of any one of the compounds of described above and herein, where the label is selected from the group consisting of: .sup.2H, .sup.3H, .sup.11C, .sup.13C, .sup.14C, .sup.32Cl, .sup.13N, .sup.18F, .sup.75Br, .sup.76Br, .sup.123I, .sup.124I, .sup.125I, and .sup.131I.

[0032] One exemplary pharmaceutical composition, among others, includes: a composition including any of the compositions described above or herein a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In an embodiment, the compound can be a labeled compound.

[0033] One exemplary method of imaging, among others, includes: contacting or administering to a tissue, cells, or a host a labeled compound described above or herein, and imaging the tissue, cells, or host, with an imaging system.

[0034] One exemplary method of diagnosing the presence of CRF.sub.1 related disease or condition or related biological events in a tissue, cells, or a host, among others, includes: contacting or administering to a tissue, cells, or a host, a labeled compound described above or herein; and imaging the tissue, cells, or a host with an imaging system, wherein the location of the labeled compound corresponds to the location of the CRF.sub.1 related disease or condition or related biological events.

[0035] One exemplary composition, among others, includes: a compound selected from the group consisting of:

##STR00006##

wherein X is a halogen; R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl,

##STR00007##

R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl; wherein R.sup.12 is selected from the group consisting of: --H, --OH, --O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; wherein R.sup.13 is selected from the group consisting of: --H, alkyl, haloalkyl, and heteroalkyl; wherein R.sup.14 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl.

[0036] One exemplary composition, among others, includes: reacting

##STR00008##

in the presence of a haloacetyl halide or a haloacetic anhydride to form

##STR00009##

wherein X is a halogen; R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl,

##STR00010##

R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl; wherein R.sup.12 is selected from the group consisting of: --H, --OH, --O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; wherein R.sup.13 is selected from the group consisting of: --H, alkyl, haloalkyl, and heteroalkyl; wherein R.sup.14 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl.

DRAWINGS

[0037] Many aspects of this disclosure can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure.

[0038] FIG. 1 depicts an H NMR spectra demonstrating diastereotopic splitting due to atropisomerism.

[0039] FIG. 2 depicts a thermal ellipsoid representation of the X-ray crystal structure of compound number 8374.HCl (Table 8, R.sup.1=Bu, R.sup.2=Et, R.sup.6=H, R.sup.7=H).

[0040] FIG. 3 depicts a thermal ellipsoid representation of the X-ray crystal structure of XXXII.

[0041] FIG. 4 depicts a thermal ellipsoid representation of the X-ray crystal structure of XXXIII.

DETAILED DESCRIPTION

[0042] This disclosure is not limited to particular embodiments described, and as such may, of course, vary. The terminology used herein serves the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present disclosure will be limited only by the appended claims.

[0043] Where a range of values is provided, each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the disclosure. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges and are also encompassed within the disclosure, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the disclosure.

[0044] Ratios, concentrations, amounts, and other numerical data may be expressed herein in a range format. Such a range format is used for convenience and brevity, and thus, should be interpreted in a flexible manner to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. For illustration purposes only, a concentration range of "about 0.1% to about 5%" should be interpreted to include not only the explicitly recited concentration of about 0.1 wt % to about 5 wt %, but also include individual concentrations (e.g., 1%, 2%, 3%, and 4%) and the sub-ranges (e.g., 0.5%, 1.1%, 2.2%, 3.3%, and 4.4%) within the indicated range. The term "about" can include .+-.1%, .+-.2%, .+-.3%, .+-.4%, .+-.5%, .+-.6%, .+-.7%, .+-.8%, .+-.9%, or .+-.10%, or more of the numerical value(s) being modified.

[0045] As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present disclosure. Any recited method may be carried out in the order of events recited or in any other order that is logically possible.

[0046] Embodiments of the present disclosure will employ, unless otherwise indicated, techniques of medicine, organic chemistry, biochemistry, molecular biology, pharmacology, and the like, which are within the skill of the art. Such techniques are explained fully in the literature.

[0047] Each of the applications and patents cited in this text, as well as each document or reference cited in each of the applications and patents (including during the prosecution of each issued patent; "application cited documents"), and each of the PCT and foreign applications or patents corresponding to and/or claiming priority from any of these applications and patents, and each of the documents cited or referenced in each of the application cited documents, are hereby expressly incorporated herein by reference. Further, documents or references cited in this text, in a Reference List before the claims, or in the text itself; and each of these documents or references ("herein cited references"), as well as each document or reference cited in each of the herein-cited references (including any manufacturer's specifications, instructions, etc.) are hereby expressly incorporated herein by reference.

[0048] Prior to describing the various embodiments, the following definitions are provided and should be used unless otherwise indicated.

DEFINITIONS

[0049] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art of molecular biology, medicinal chemistry, and/or organic chemistry. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described herein.

[0050] As used in the specification and the appended claims, the singular forms "a," "an," and "the" may include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "a support" includes a plurality of supports. In this specification and in the claims that follow, reference will be made to a number of terms that shall be defined to have the following meanings unless a contrary intention is apparent.

[0051] As used herein, "alkyl" or "alkyl group" refers to a saturated aliphatic hydrocarbon radical which may be straight or branched, having 1 to 20 carbon atoms, wherein the stated range of carbon atoms includes each intervening integer individually, as well as sub-ranges. Examples of alkyl groups include, but are not limited to, methyl, ethyl, i-propyl, n-propyl, n-butyl, t-butyl, pentyl, hexyl, septyl, octyl, nonyl, decyl, and the like.

[0052] As used herein, "alkenyl" or "alkenyl group" refers to an aliphatic hydrocarbon radical which may be straight or branched, containing at least one carbon-carbon double bond, having 2 to 20 carbon atoms, wherein the stated range of carbon atoms includes each intervening integer individually, as well as sub-ranges. Examples of alkenyl groups include, but are not limited to, ethenyl, propenyl, n-butenyl, i-butenyl, 3-methylbut-2-enyl, n-pentenyl, heptenyl, octenyl, decenyl, and the like.

[0053] As used herein, "halo", "halogen", or "halogen radical" refers to a fluorine, chlorine, bromine, and iodine radicals. Further, when used in compound words, such as "haloalkyl" or "haloalkenyl", "halo" refers to an alkyl or alkenyl radical in which one or more hydrogens are substituted by halogen radicals.

[0054] As used herein, "heteroalkyl" refers to an alkyl group as defined above, in which one or more carbon atoms are substituted by nitrogen, oxygen, phosphorus, or sulfur atoms. Examples of heteroalkyl groups include, but are not limited to, ethoxymethyl, cyano, 2,3-dioxyethyl, and the like.

[0055] The term "unit dosage form," as used herein, refers to physically discrete units suitable as unitary dosages for human and/or animal subjects, each unit containing a predetermined quantity of a compound (e.g., an anti-viral compound, as described herein) calculated in an amount sufficient to produce the desired effect in association with a pharmaceutically acceptable diluent, carrier or vehicle. The specifications for unit dosage forms depend on the particular compound employed, the route and frequency of administration, and the effect to be achieved, and the pharmacodynamics associated with each compound in the host.

[0056] A "pharmaceutically acceptable excipient," "pharmaceutically acceptable diluent," "pharmaceutically acceptable carrier," or "pharmaceutically acceptable adjuvant" means an excipient, diluent, carrier, and/or adjuvant that are useful in preparing a pharmaceutical composition that are generally safe, non-toxic and neither biologically nor otherwise undesirable, and include an excipient, diluent, carrier, and adjuvant that are acceptable for veterinary use and/or human pharmaceutical use. "A pharmaceutically acceptable excipient, diluent, carrier and/or adjuvant" as used in the specification and claims includes one and more such excipients, diluents, carriers, and adjuvants.

[0057] As used herein, a "pharmaceutical composition" is meant to encompass a composition suitable for administration to a subject, such as a mammal, especially a human. In general a "pharmaceutical composition" is sterile, and preferably free of contaminants that are capable of eliciting an undesirable response within the subject (e.g., the compound(s) in the pharmaceutical composition is pharmaceutical grade). Pharmaceutical compositions can be designed for administration to subjects or patients in need thereof via a number of different routes of administration including oral, intravenous, buccal, rectal, parenteral, intraperitoneal, intradermal, intracheal, intramuscular, subcutaneous, inhalational and the like.

[0058] The term "therapeutically effective amount" as used herein refers to that amount of an embodiment of the agent (which may be referred to as a compound, an inhibitory agent, and/or a drug) being administered that will relieve to some extent one or more of the symptoms of the disease, i.e., infection, being treated, and/or that amount that will prevent, to some extent, one or more of the symptoms of the disease, i.e., infection, that the host being treated has or is at risk of developing.

[0059] "Pharmaceutically acceptable salt" refers to those salts that retain the biological effectiveness and optionally other properties of the free bases and that are obtained by reaction with inorganic or organic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, malic acid, maleic acid, succinic acid, tartaric acid, citric acid, and the like.

[0060] In the event that embodiments of the disclosed agents form salts, these salts are within the scope of the present disclosure. Reference to an agent of any of the formulas herein is understood to include reference to salts thereof, unless otherwise indicated. The term "salt(s)", as employed herein, denotes acidic and/or basic salts formed with inorganic and/or organic acids and bases. In addition, when an agent contains both a basic moiety and an acidic moiety, zwitterions ("inner salts") may be formed and are included within the term "salt(s)" as used herein. Pharmaceutically acceptable (e.g., non-toxic, physiologically acceptable) salts are preferred, although other salts are also useful, e.g., in isolation or purification steps which may be employed during preparation. Salts of the compounds of an agent may be formed, for example, by reacting the agent with an amount of acid or base, such as an equivalent amount, in a medium such as one in which the salt precipitates or in an aqueous medium followed by lyophilization.

[0061] Embodiments of the agents that contain a basic moiety may form salts with a variety of organic and inorganic acids. Exemplary acid addition salts include acetates (such as those formed with acetic acid or trihaloacetic acid, for example, trifluoroacetic acid), adipates, alginates, ascorbates, aspartates, benzoates, benzenesulfonates, bisulfates, borates, butyrates, citrates, camphorates, camphorsulfonates, cyclopentanepropionates, digluconates, dodecylsulfates, ethanesulfonates, fumarates, glucoheptanoates, glycerophosphates, hemisulfates, heptanoates, hexanoates, hydrochlorides (formed with hydrochloric acid), hydrobromides (formed with hydrogen bromide), hydroiodides, 2-hydroxyethanesulfonates, lactates, maleates (formed with maleic acid), methanesulfonates (formed with methanesulfonic acid), 2-naphthalenesulfonates, nicotinates, nitrates, oxalates, pectinates, persulfates, 3-phenylpropionates, phosphates, picrates, pivalates, propionates, salicylates, succinates, sulfates (such as those formed with sulfuric acid), sulfonates (such as those mentioned herein), tartrates, thiocyanates, toluenesulfonates such as tosylates, undecanoates, and the like.

[0062] Embodiments of the agents that contain an acidic moiety may form salts with a variety of organic and inorganic bases. Exemplary basic salts include ammonium salts, alkali metal salts such as sodium, lithium, and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases (for example, organic amines) such as benzathines, dicyclohexylamines, hydrabamines (formed with N,N-bis(dehydroabietyl)ethylenediamine), N-methyl-D-glucamines, N-methyl-D-glucamides, t-butyl amines, and salts with amino acids such as arginine, lysine, and the like.

[0063] Basic nitrogen-containing groups may be quaternized with agents such as lower alkyl halides (e.g., methyl, ethyl, propyl, and butyl chlorides, bromides and iodides), dialkyl sulfates (e.g., dimethyl, diethyl, dibutyl, and diamyl sulfates), long chain halides (e.g., decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides), aralkyl halides (e.g., benzyl and phenethyl bromides), and others.

[0064] Solvates of the agents of the disclosure are also contemplated herein.

[0065] To the extent that the disclosed active compounds, and salts thereof, may exist in their tautomeric form, all such tautomeric forms are contemplated herein as part of the present disclosure.

[0066] All stereoisomers of the agents, such as those that may exist due to asymmetric carbons on the various substituents, including enantiomeric forms (which may exist even in the absence of asymmetric carbons) and diastereomeric forms, are contemplated within the scope of this disclosure. Individual stereoisomers of the compounds of the disclosure may, for example, be substantially free of other isomers, or may be admixed, for example, as racemates or with all other, or other selected, stereoisomers. The stereogenic centers of the compounds of the present disclosure can have the S or R configuration as defined by the IUPAC 1974 Recommendations.

[0067] The term "prodrug" refers to an inactive precursor of an agent that is converted into a biologically active form in vivo. Prodrugs are often useful because, in some situations, they may be easier to administer than the parent compound. They may, for instance, be bioavailable by oral administration whereas the parent compound is not. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug. A prodrug may be converted into the parent drug by various mechanisms, including enzymatic processes and metabolic hydrolysis. Harper, N.J. (1962). Drug Latentiation in Jucker, ed. Progress in Drug Research, 4:221-294; Morozowich et al. (1977). Application of Physical Organic Principles to Prodrug Design in E. B. Roche ed. Design of Biopharmaceutical Properties through Prodrugs and Analogs, APhA; Acad. Pharm. Sci.; E. B. Roche, ed. (1977). Bioreversible Carriers in Drug in Drug Design, Theory and Application, APhA; H. Bundgaard, ed. (1985) Design of Prodrugs, Elsevier; Wang et al. (1999) Prodrug approaches to the improved delivery of peptide drug, Curr. Pharm. Design. 5(4):265-287; Pauletti et al. (1997). Improvement in peptide bioavailability: Peptidomimetics and Prodrug Strategies, Adv. Drug. Delivery Rev. 27:235-256; Mizen et al. (1998). The Use of Esters as Prodrugs for Oral Delivery of .beta.-Lactam antibiotics, Pharm. Biotech. 11:345-365; Gaignault et al. (1996). Designing Prodrugs and Bioprecursors I. Carrier Prodrugs, Pract. Med. Chem. 671-696; M. Asgharnejad (2000). Improving Oral Drug Transport Via Prodrugs, in G. L. Amidon, P. I. Lee and E. M. Topp, Eds., Transport Processes in Pharmaceutical Systems, Marcell Dekker, p. 185-218; Balant et al. (1990) Prodrugs for the improvement of drug absorption via different routes of administration, Eur. J. Drug Metab. Pharmacokinet., 15(2): 143-53; Balimane and Sinko (1999). Involvement of multiple transporters in the oral absorption of nucleoside analogues, Adv. Drug Delivery Rev., 39(1-3):183-209; Browne (1997). Fosphenyloin (Cerebyx), Clin. Neuropharmacol. 20(1): 1-12; Bundgaard (1979). Bioreversible derivatization of drugs--principle and applicability to improve the therapeutic effects of drugs, Arch. Pharm. Chemi. 86(1): 1-39; H. Bundgaard, ed. (1985) Design of Prodrugs, New York: Elsevier; Fleisher et al. (1996). Improved oral drug delivery: solubility limitations overcome by the use of prodrugs, Adv. Drug Delivery Rev. 19(2): 115-130; Fleisher et al. (1985). Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting, Methods Enzymol. 112: 360-81; Farquhar D, et al. (1983). Biologically Reversible Phosphate-Protective Groups, J. Pharm. Sci., 72(3): 324-325; Han, H. K. et al. (2000). Targeted prodrug design to optimize drug delivery, AAPS PharmSci., 2(1): E6; Sadzuka Y. (2000). Effective prodrug liposome and conversion to active metabolite, Curr. Drug Metab., 1(1):31-48; D. M. Lambert (2000) Rationale and applications of lipids as prodrug carriers, Eur. J. Pharm. Sci., 11 Suppl 2:S15-27; Wang, W. et al. (1999) Prodrug approaches to the improved delivery of peptide drugs. Curr. Pharm. Des., 5(4):265-87.

[0068] The term "administration" refers to introducing an agent of the present disclosure into a host. One preferred route of administration of the agents is oral administration. Another preferred route is intravenous administration. However, any route of administration, such as topical, subcutaneous, peritoneal, intraarterial, inhalation, vaginal, rectal, nasal, introduction into the cerebrospinal fluid, or instillation into body compartments can be used.

[0069] As used herein, the terms "treatment", "treating", and "treat" are defined as acting upon a disease, disorder, or condition with an agent (e.g., compound described herein) to reduce or ameliorate the pharmacologic and/or physiologic effects of the disease, disorder, or condition and/or its symptoms. "Treatment," as used herein, covers any treatment of a disease in a host (e.g., a mammal, typically a human or non-human animal of veterinary interest), and includes: (a) reducing the risk of occurrence of the disease in a subject determined to be predisposed to the disease but not yet diagnosed as infected with the disease, (b) impeding the development of the disease, and (c) relieving the disease, i.e., causing regression of the disease and/or relieving one or more disease symptoms. "Treatment" is also meant to encompass delivery of an agent (e.g., compound described herein) to provide a pharmacologic effect, even in the absence of a disease or condition. For example, "treatment" encompasses delivery of an agent that provides for enhanced or desirable effects in the subject (e.g., reduction of disease symptoms, etc.).

[0070] As used herein, the terms "prophylactically treat" or "prophylactically treating" refers completely or partially (e.g., about 70% or greater, about 80% or greater, about 90% or greater, about 95% or greater) preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete cure for a disease and/or adverse effect attributable to the disease. The terms "treatment", "treating", and "treat" are distinguishable from the terms "prophylactically treat" or "prophylactically treating" as their definitions disclose and thereby have distinct meanings.

[0071] As used herein, the term "host," "subject," "patient," or "organism" includes humans and mammals (e.g., mice, rats, pigs, cats, dogs, and horses). Typical hosts to which compounds of the present disclosure may be administered will be mammals, particularly primates, especially humans. For veterinary applications, a wide variety of subjects will be suitable, e.g., livestock such as cattle, sheep, goats, cows, swine, and the like; poultry such as chickens, ducks, geese, turkeys, and the like; and domesticated animals particularly pets such as dogs and cats. For diagnostic or research applications, a wide variety of mammals will be suitable subjects, including rodents (e.g., mice, rats, hamsters), rabbits, primates, and swine such as inbred pigs and the like. The term "living host" refers to a host noted above or another organism that is alive. The term "living host" refers to the entire host or organism and not just a part excised (e.g., a liver or other organ) from the living host.

Discussion:

[0072] The present disclosure provides compounds including a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF.sub.1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF.sub.1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

[0073] Embodiments of the present disclosure include methods for imaging tissue, cells, or a host (e.g., a human or a mammal) that includes contacting with or administering to a tissue, cells, or host (e.g., human), labeled triamino-pyridine derivatives, and imaging the tissue with and imaging systems such as a PET imaging system or a SPECT system. The imaging can be performed in vivo and/or in vitro. In particular, embodiments of the present disclosure can be used to image CRF.sub.1 related diseases or conditions, or related biological events. In this regard, the tissue, cells, or host can be tested to determine if the tissue, cells, or host include a CRF.sub.1 related disease or condition or related biological events, monitor the progression (or regression) of the disease or condition, assess the response of the disease or condition to treatment, and the like. The tissue or cells can be within a host or have been removed from a host.

[0074] The CRF.sub.1 related diseases or conditions can include the following as well as or related biological events for any of these: depression and depressive symptoms such as major depression, single-episode depression, recurrent depression, depression-induced child abuse and postpartum depression, mania, anxiety, generalized anxiety disorder, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, Tourette's syndrome, autism, affective disorder, dysthymia, bipolar disorder, cyclothymic personality, schizophrenia, Alzheimer's disease, senile dementia of Alzheimer's type, neurodegenerative disease such as Parkinson's disease and Huntington's disease, multi-infarct dementia, senile dementia, anorexia nervosa, hyperphagia and other eating disorders, obesity, diabetes, alcohol dependence, pharmacophilia for drugs such as cocaine, heroin or benzodiazepines, drug or alcohol withdrawal symptoms, sleep disorder, insomnia, migraine, stress-induced headache, muscle contraction induced headache, ischemic neuronal damage, excitotoxic neuronal damage, stroke, progressive supranuclear palsy, amyotrophic lateral sclerosis, multiple sclerosis, muscular spasm, chronic fatigue syndrome, psychosocial dwarfism, epilepsy, head trauma, spinal cord injury, cheirospasm, spasmodic torticollis, cervicobrachial syndrome, primary glaucoma, Meniere's syndrome, autonomic imbalance, alopecia, neuroses such as cardiac neurosis, gastric neurosis and bladder neurosis, peptic ulcer, irritable bowel syndrome, ulcerative colitis, Crohn's disease, diarrhea, constipation, postoperative ileus, stress-associated gastrointestinal disorders and nervous vomiting, hypertension, cardiovascular disorders such as angina pectoris nervosa, tachycardia, congestive heart failure, hyperventilation syndrome, bronchial asthma, apneusis, sudden infant death syndrome, inflammatory disorders (e.g., rheumatic arthritis, osteoarthritis, lumbago, etc.), pain, allergosis (e.g., atopic dermatitis, eczema, hives, psoriasis, etc.), impotence (erectile dysfunction), menopausal disorder, fertilization disorder, infertility, cancer, HIV infection-related immune dysfunction, stress-induced immune dysfunction, hemorrhagic stress, Cushing's syndrome, thyroid function disorder, encephalomyelitis, acromegaly, incontinence, osteoporosis, and the like. It should be noted that embodiments of the present disclosure contemplates that the CRF.sub.1 related diseases or conditions can include any one of the above or any combination of two or more of the above.

[0075] As noted above, embodiments of the present disclosure include triamino-pyridine derivatives such as optionally substituted 6-methyl-2,3,4-triamino-pyridine derivatives or labeled compounds thereof, designed as ligands for the corticotropin releasing factor type-1 (CRF.sub.1) receptor.

[0076] An embodiment of the present disclosure includes a compound according to either formula (1a)

##STR00011##

or (1 b;

##STR00012##

as well as atropisomers, racemic mixtures (racemate), and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl,

##STR00013##

R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl. Each of R.sup.9 and R.sup.10 are each independently selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl. In each instance of R.sup.9, each R.sup.9 can be independently selected from the other R.sup.9 moities of the formula.

[0077] R.sup.11 is selected from the group consisting of:

##STR00014##

[0078] Each R.sup.3 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, --NO.sub.2, --NH, --NH-alkyl, --N(alkyl).sub.2, --N(alkyl).sub.3OTf, --N(alkyl).sub.3X, --Sn(alkyl).sub.3, --SH, --S-alkyl, and --S-haloalkyl. If n is 2 or 3, R.sup.3 is chosen independently of any other R.sup.3. Each of R.sup.4, R.sup.5, and R.sup.6 are each independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, and --Sn(alkyl).sub.3, in which n, o, p, and q are each independently 1, 2, or 3. If any of o, p, or q are 2 or 3, each of R.sup.4, R.sup.5, and R.sup.6 are chosen independently of each other and any other R.sup.4, R.sup.5, and R.sup.6. R.sup.7 is selected from the group consisting of: --H and alkyl. Each R.sup.4 can be independently selected from the other R.sup.4 groups. Each R.sup.5 can be independently selected from the other R.sup.5 groups. Each R.sup.6 can be independently selected from the other R.sup.6 groups.

[0079] R.sup.12 is selected from the group consisting of: --H, --OH, --O-alkyl, alkyl, X, haloalkyl, and heteroalkyl. R.sup.13 is selected from the group consisting of: H, alkyl, haloalkyl, and heteroalkyl. X represents a halogen moiety. X.sup.2 is selected from the group consisting of: --H, alkyl, --X, and --Sn(alkyl).sub.3. R.sup.15 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl. R.sup.14 is selected from the group consisting of: --H, halogen, alkyl, haloalkyl, and heteroalkyl.

[0080] An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. Each R.sup.3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CH.sub.2F, --CHF.sub.2, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, --OCH.sub.2CH.sub.2CH.sub.2F, --SH, --SCH.sub.3, --SCH.sub.2F, --SCH.sub.2CH.sub.2F, --SCH.sub.2CH.sub.2CH.sub.2F, --SCHF.sub.2, --SCF.sub.3, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --N(CH.sub.3).sub.3OTf (Tf is triflate), and --N(CH.sub.3).sub.3I. R.sup.9 is H. R.sup.10 is methyl. R.sup.11 is

##STR00015##

The variable n is 1, 2, or 3. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0081] An embodiment of the present disclosure includes a compound according to formula (VI),

##STR00016##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.3, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0082] An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. In an embodiment R.sup.5 is H. R.sup.9 is H. R.sup.10 is methyl. R.sup.11 is

##STR00017##

The variable o is 1 or 2. The variable p is 1. X.sup.2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH.sub.3).sub.3.

[0083] An embodiment of the present disclosure includes a compound according to formula (VII),

##STR00018##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.4, o, and X.sup.2 are as previously defined. Each R.sup.4 can be independently selected from the other R.sup.4 groups.

[0084] An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.11 is

##STR00019##

R.sup.9 is H. R.sup.10 is methyl. R.sup.4 is H. R.sup.5 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. Each R.sup.5 can be independently selected from the other R.sup.5 groups. X.sup.2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH.sub.3).sub.3. The variable o is 1. The variable p is 1 or 2.

[0085] An embodiment of the present disclosure includes a compound according to formula (VIII),

##STR00020##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.5, o, and X.sup.2 are as previously defined. Each R.sup.5 can be independently selected from the other R.sup.5 groups.

[0086] An embodiment of the present disclosure includes a compound according to formula (1), in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.6 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. R.sup.7 is H or methyl. R.sup.9 is H. R.sup.16 is methyl. R.sup.11 is

##STR00021##

The variable q is 1 or 2. Each R.sup.6 can be independently selected from the other R.sup.3 groups.

[0087] An embodiment of the present disclosure includes a compound according to formula (XIII),

##STR00022##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.6, R.sup.7, and q are as previously defined. Each R.sup.6 can be independently selected from the other R.sup.6 groups.

[0088] An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of:

##STR00023##

R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.9 is H. R.sup.10 is methyl.

[0089] R.sup.11 is

##STR00024##

R.sup.12, R.sup.13, and R.sup.14 are previously described above. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0090] For any of the aforementioned embodiments pertaining to formula (1), when R.sup.11 is

##STR00025##

R.sup.1 is butyl and R.sup.2 is ethyl, R.sup.3 is not: 2-Br-4-Pr; 2,4-Cl; 2,4,6-CH.sub.3; 2-Cl-4-OCH.sub.3; or 2-CH.sub.3-4-OCH.sub.3. Put alternatively, when R.sup.11 is

##STR00026##

R.sup.1 is butyl, and R.sup.2 is ethyl, then R.sup.3 is not:

[0091] (1) bromine at the 2-position and iso-propyl at the 4-position;

[0092] (2) chlorine at the 2- and 4-positions;

[0093] (3) methyl at the 2-, 4-, and 6-positions;

[0094] (4) chlorine at the 2-position and methoxy at the 4-position; or

[0095] (5) methyl at the 2-position and methoxy at the 4-position.

[0096] An embodiment of the present disclosure includes a compound according to formula (XXXXI),

##STR00027##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.2, R.sup.3, R.sup.12, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0097] An embodiment of the present disclosure includes a compound according to formula (XXXXII),

##STR00028##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.2, R.sup.3, R.sup.12, R.sup.13, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0098] An embodiment of the present disclosure includes a compound according to formula (XXXXIII),

##STR00029##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.2, R.sup.3, R.sup.12, R.sup.13, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0099] An embodiment of the present disclosure includes a compound according to formula (1), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.11 is selected from the group consisting of:

##STR00030##

where R.sup.12, R.sup.13, and R.sup.14 are as previously defined.

[0100] An embodiment of the present disclosure includes a compound according to formula (XXXVIII),

##STR00031##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R.sup.1, R.sup.2, and R.sup.12 are as previously defined.

[0101] An embodiment of the present disclosure includes a compound according to formula (XXXIX),

##STR00032##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R.sup.1, R.sup.2, R.sup.12, and R.sup.13 are as previously defined.

[0102] An embodiment of the present disclosure includes a compound according to formula (XXXIX),

##STR00033##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, wherein R.sup.1, R.sup.2, R.sup.12, and R.sup.13 are as previously defined.

[0103] An embodiment of the present disclosure includes a compound according to formula (2),

##STR00034##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, and haloalkenyl. R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl. R.sup.9 and R.sup.10 are independently selected from the group consisting of: --H and alkyl. Each R.sup.9 can be independently selected from the other R.sup.9 moieties. R.sup.11 is selected from the group consisting of:

##STR00035##

X represents a halogen moiety. X.sup.2 is selected from the group consisting of: --H, alkyl, --X, and --Sn(alkyl).sub.3.

[0104] Each R.sup.3 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, --NO.sub.2, --NH, --NH-alkyl, --N(alkyl).sub.2, --N(alkyl).sub.3OTf, --N(alkyl).sub.3X, --Sn(alkyl).sub.3, --SH, --S-alkyl, and --S-haloalkyl, in which n is selected from the group consisting of: 1, 2, and 3. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.4, R.sup.5, and R.sup.6 are each independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, and --Sn(alkyl).sub.3, in which o, p, and q are each independently 1, 2, or 3. R.sup.7 is selected from the group consisting of: --H and alkyl. Each R.sup.3 can be independently selected from the other R.sup.3 groups. Each R.sup.4 can be independently selected from the other R.sup.4 groups. Each R.sup.5 can be independently selected from the other R.sup.5 groups. Each R.sup.6 can be independently selected from the other R.sup.6 groups.

[0105] An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. Each R.sup.3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCH.sub.2CH.sub.2F, --OCH.sub.2CH.sub.2CH.sub.2F, --SH, --SCH.sub.3, --SCH.sub.2F, --SCH.sub.2CH.sub.2F, --SCH.sub.2CH.sub.2CH.sub.2F, --SCF.sub.3, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --N(CH.sub.3).sub.3OTf, and --N(CH.sub.3).sub.31. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.9 is H. R.sup.10 is methyl. R.sup.11 is

##STR00036##

The variable n is 1, 2, or 3. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0106] An embodiment of the present disclosure includes a compound according to formula (X),

##STR00037##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.3, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0107] An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. Each R.sup.4 can be independently selected from the other R.sup.4 groups. R.sup.5 is H. R.sup.9 is H. R.sup.10 is methyl. R.sup.11 is

##STR00038##

The variable o is 1 or 2. The variable p is 1. X.sup.2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH.sub.3).sub.3.

[0108] An embodiment of the present disclosure includes a compound according to formula (XI),

##STR00039##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.4, o, and X.sup.2 are as previously defined. Each R.sup.4 can be independently selected from the other R.sup.4 groups.

[0109] An embodiment of the present disclosure includes a compound according to formula (2), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.11 is

##STR00040##

R.sup.9 is H. R.sup.10 is methyl. R.sup.4 is H. Each R.sup.5 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2--OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. Each R.sup.5 can be independently selected from the other R.sup.5 groups. X.sup.2 is selected from the group consisting of: H, methyl, iodo, chloro, bromo, fluoro, and Sn(CH.sub.3).sub.3. The variable o is 1. The variable p is 1 or 2.

[0110] An embodiment of the present disclosure includes a compound according to formula (XII),

##STR00041##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.5, o, and X.sup.2 are as previously defined. Each R.sup.5 can be independently selected from the other R.sup.5 groups.

[0111] An embodiment of the present disclosure includes a compound according to formula (3),

##STR00042##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, and haloalkenyl. R.sup.2 is selected from the group consisting of: --H, alkyl, and haloalkyl. Each R.sup.4 is selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, and --Sn(alkyl).sub.3. Each R.sup.4 can be independently selected from the other R.sup.4 groups. R.sup.9 and R.sup.10 are independently selected from the group consisting of: --H and alkyl. Each R.sup.9 can be independently selected from the other R.sup.9 groups. The variables o and z are independently 1, 2, or 3. X represents a halogen moiety.

[0112] An embodiment of the present disclosure includes a compound according to formula (3), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1 is selected from the group consisting of: butyl, propyl, fluoropropyl, fluorobutyl, and FCH.sub.2--CH.dbd.CH--CH.sub.2. R.sup.2 is selected from the group consisting of: methyl, ethyl, propyl, fluoroethyl, and fluoropropyl. R.sup.4 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CF.sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF2, --OCH.sub.2CH.sub.2F, and --OCH.sub.2CH.sub.2CH.sub.2F. R.sup.9 is H. R.sup.10 is methyl. The variable o is 1 or 2. The variable z is 1, 2, or 3.

[0113] An embodiment of the present disclosure includes a compound according to formulae

##STR00043##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.1, R.sup.2, R.sup.4, o, and z are as previously defined. Each R.sup.4 can be independently selected from the other R.sup.4 groups.

[0114] An embodiment of the present disclosure includes a compound according to formula (4),

##STR00044##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, --NO.sub.2, --NH, --NH-alkyl, --N(alkyl).sub.2, --N(alkyl).sub.3OTf, --N(alkyl).sub.3X, --Sn(alkyl).sub.3, --SH, --S-alkyl, and --S-haloalkyl, in which n is 1, 2, or 3. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.8 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl, and

##STR00045##

R.sup.9 and R.sup.10 are independently selected from the group consisting of: --H and alkyl. X is a halogen moiety. R.sup.12 and R.sup.14 are described above. The variable y is 1 or 2.

[0115] An embodiment of the present disclosure includes a compound according to formula (4), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CH.sub.2F, --CHF.sub.2, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, --OCH.sub.2CH.sub.2CH.sub.2F, --SH, --SCH.sub.3, --SCH.sub.2F, --SCHF2, --SCH.sub.2CH.sub.2F, --SCH.sub.2CH.sub.2CH.sub.2F, --SCF.sub.3, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --N(CH.sub.3).sub.3OTf, and --N(CH.sub.3).sub.31. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.8 is selected from the group consisting of: H, methyl, ethyl, propyl, butyl, fluoromethyl, fluoroethyl, fluoropropyl, fluorobutyl, benzyl, FCH.sub.2--CH.dbd.CH--CH.sub.2, and

##STR00046##

R.sup.9 is H. R.sup.10 is methyl. The variable n is 1, 2, or 3. The variable y is 1 or 2. R.sup.12 and R.sup.14 are described above.

[0116] An embodiment of the present disclosure includes a compound according to formula (XIV),

##STR00047##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3, R.sup.8, n, and y are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0117] An embodiment of the present disclosure includes a compound according to formula (5),

##STR00048##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, --NO.sub.2, --NH, --NH-alkyl, --N(alkyl).sub.2, --N(alkyl).sub.3OTf, --N(alkyl).sub.3X, --Sn(alkyl).sub.3, --SH, --S-alkyl, and --S-haloalkyl, in which n is selected from the group consisting of: 1, 2, and 3. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.8 is selected from the group consisting of: --H, alkyl, alkenyl, haloalkyl, haloalkenyl, and

##STR00049##

R.sup.9 and R.sup.10 are independently selected from the group consisting of: --H and alkyl. X is a halogen moiety. R.sup.12 and R.sup.14 are described above.

[0118] An embodiment of the present disclosure includes a compound according to formula (5), as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3 is independently selected from the group consisting of: H, methyl, ethyl, propyl, butyl, iodo, chloro, fluoro, bromo, --CH.sub.2F, --CHF.sub.2, --CF.sub.3, --Sn(CH.sub.3).sub.3, --OH, --OCH.sub.3, --OCF.sub.3, --OCH.sub.2F, --OCHF.sub.2, --OCH.sub.2CH.sub.2F, --OCH.sub.2CH.sub.2CH.sub.2F, --SH, --SCH.sub.3, --SCH.sub.2F, --SCHF.sub.2, --SCH.sub.2CH.sub.2F, --SCH.sub.2CH.sub.2CH.sub.2F, --SCF.sub.3, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --N(CH.sub.3).sub.3OTf, and --N(CH.sub.3).sub.31. Each R.sup.3 can be independently selected from the other R.sup.3 groups. R.sup.8 is selected from the group consisting of: H, methyl, ethyl, propyl, butyl, fluoromethyl, fluoroethyl, fluoropropyl, fluorobutyl, benzyl, FCH.sub.2--CH.dbd.CH--CH.sub.2, and

##STR00050##

R.sup.9 is H. R.sup.10 is methyl. R.sup.12 and R.sup.14 are described above. The variable n is 1, 2, or 3.

[0119] An embodiment of the present disclosure includes a compound according to formulae (XV),

##STR00051##

as well as atropisomers, racemic mixtures, and stereoisomers of any of the foregoing, and pharmaceutically acceptable salts of any of the foregoing, and labeled compounds of any of the foregoing, in which R.sup.3, R.sup.8, and n are as previously defined. Each R.sup.3 can be independently selected from the other R.sup.3 groups.

[0120] As described above, embodiments of the present disclosure include labeled triamino-pyridine derivatives such as labeled compounds of formulae (1), (2), (3), (4), (5), (VI), (VII), (VIII), (IXa), (IXb), (X), (XI), (XII), (XIII), (XIV), and (XV).

[0121] The labeled triamino-pyridine derivatives can be imaged using imaging systems such as positron emission tomography (PET) imaging systems, single photon emission computed tomography (SPECT), and the like. The PET and SPECT imaging systems are known in the art. In an embodiment, the labeled triamino-pyridine derivatives includes a label can be used to detect, image, or otherwise identify the labeled triamino-pyridine derivatives, quantify the amount of labeled triamino-pyridine derivatives, determine the location of the labeled triamino-pyridine derivatives (e.g., in imaging), and combinations thereof.

[0122] In an embodiment, the labeled triamino-pyridine derivative can include a radiolabel and/or a compound including a radiolabel. In an embodiment, the label is a radiolabel. In an embodiment, the radiolabel (e.g., non-radiolabels and their radiolabel counterparts) can include, but is not limited to, F-19 (F-18), C-12 (C-11), 1-127 (1-125, I-124, I-131, I-123), Cl-36 (Cl-32, Cl-33, Cl-34), and Br-80 (Br-74, Br-75, Br-76, Br-77, Br-78). It should be noted that an alternative way to represent F-18, C-11, and the like, is the following: .sup.18F and .sup.11C respectively, and both ways are used herein. In an embodiment, the radiolabel can be .sup.2H, .sup.3H, .sup.11C, .sup.13C, .sup.14Cl, .sup.32Cl, .sup.13N, .sup.18F, .sup.75Br, .sup.76Br, .sup.123I, .sup.124I, .sup.125I, .sup.131I. In an embodiment, the PET radiolabel can be .sup.16F, .sup.76Br, or .sup.124I or .sup.131I or combinations thereof. The SPECT isotope can include, but is not limited to, .sup.123I, .sup.125I, .sup.131I, .sup.99Tc, .sup.111In, .sup.186/188Re, or combinations thereof.

[0123] An embodiment of the present disclosure includes stereoisomers of triamino-pyridine derivatives including compounds according to any of the formulae previously described, which are enantiomers, diastereomers, atropisomers, conformers, racemic mixtures (racemate), and cis/trans isomers of these compounds.

[0124] An embodiment of the present disclosure includes compositions comprising triamino-pyridine derivatives or labeled triamino-pyridine derivatives, and stereoisomers of any of these, including a compound of formulae (1), (2), (3), (4), (5), (VI), (VII), (VIII), (IXa), (IXb), (X), (XI), (XII), (XIII), (XIV), and (XV) or a pharmaceutically acceptable salt thereof. An embodiment further comprises a pharmaceutically acceptable carrier.

Methods of Use

[0125] Embodiments of this disclosure include, but are not limited to: methods of imaging tissue, cells, or a host using labeled triamino-pyridine derivatives; methods of imaging an a CRF.sub.1 related disease or condition as described herein, or related biological events; methods of diagnosing a CRF.sub.1 related disease or condition or related biological events; methods of monitoring the progress of a CRF.sub.1 related disease or condition or related biological events, and the like.

[0126] Embodiments of the present disclosure can be used to image, detect, study, monitor, evaluate, assess, and/or screen, CRF.sub.1 related disease or condition or related biological events in vivo or in vitro using labeled triamino-pyridine derivatives.

[0127] In general, the labeled triamino-pyridine derivatives can be used in imaging CRF.sub.1 related diseases or conditions. For example, the labeled triamino-pyridine derivative is provided or administered to a host in an amount effective to result in uptake of the labeled triamino-pyridine derivative. After an appropriate amount of time, the host is then introduced to an appropriate imaging system (e.g., PET system) for a certain amount of time. The cell, tissue, and/or organ that takes-up the labeled triamino-pyridine derivative could be detected using the imaging system.

[0128] In an embodiment, the labeled triamino-pyridine derivative may find use both in diagnosing and/or in treating CRF, related diseases or conditions. In diagnosing the presence of CRF.sub.1 related diseases or conditions in a host, the labeled triamino-pyridine derivative is administered to the host in an amount effective to result in uptake of the labeled triamino-pyridine derivative. After administration of the labeled triamino-pyridine derivative, the labeled triamino-pyridine derivatives are detected using an appropriate imaging system. Embodiments of the present disclosure can non-invasively image CRF.sub.1 related diseases or conditions throughout an animal or human patient.

[0129] Embodiments of the labeled triamino-pyridine derivative can also find use in a host undergoing treatment, to aid in visualizing the response of CRF.sub.1 related diseases or conditions to the treatment. In this embodiment, the labeled triamino-pyridine derivative is typically visualized and sized prior to treatment, and periodically during treatment to monitor the CRF.sub.1 related diseases or conditions.

[0130] Embodiments of the labeled triamino-pyridine derivative also finds use as a screening tool in vitro to select compounds for use in treating CRF.sub.1 related diseases or conditions. The CRF.sub.1 related diseases or conditions could be easily monitored by incubating the cells with the labeled triamino-pyridine derivative during or after incubation with one or more candidate drugs. The ability of the drug compound to affect the binding of suitably labeled triamino-pyridine derivative will confer potency of the drug.

[0131] In addition, embodiments of this disclosure include methods of treating a host using labeled triamino-pyridine derivatives, where the host has or may have a CRF.sub.1 related disease or condition as described herein, or related biological events.

[0132] It should be noted that the amount effective to result in uptake of triamino-pyridine derivative or labeled triamino-pyridine derivative into the cells or tissue or organ of interest or the host will depend upon a variety of factors, including for example, the age, body weight, general health, sex, and diet of the host; the time of administration; the route of administration; the rate of excretion of the specific compound employed; the duration of the treatment; the existence of other drugs used in combination or coincidental with the specific composition employed; and like factors well known in the medical arts.

Kits

[0133] The present disclosure also provides packaged compositions or pharmaceutical compositions comprising a pharmaceutically acceptable carrier and triamino-pyridine derivative and/or the labeled triamino-pyridine derivative of the disclosure. In certain embodiments, the packaged compositions or pharmaceutical composition includes the reaction precursors to be used to generate the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative according to the present disclosure. Other packaged compositions or pharmaceutical compositions provided by the present disclosure further include indicia including at least one of: instructions for using the composition to image a host, or host samples (e.g., cells or tissues), which can be used as an indicator of conditions including, but not limited to, CRF.sub.1 related diseases or conditions and biological related events. In embodiments, the kit may include instructions for using the composition or pharmaceutical composition to assess therapeutic effect of a drug protocol administered to a patient, instructions for using the composition to selectively image CRF.sub.1 related diseases or conditions, and instructions for using the composition to predict metastatic potential.

[0134] Embodiments of this disclosure encompass kits that include, but are not limited to, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and directions (written instructions for their use). The components listed above can be tailored to the particular biological event to be monitored as described herein. The kit can further include appropriate buffers and reagents known in the art for administering various combinations of the components listed above to the host cell or host organism. The triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and carrier may be provided in solution or in lyophilized form. When the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative and carrier of the kit are in lyophilized form, the kit may optionally contain a sterile and physiologically acceptable reconstitution medium such as water, saline, buffered saline, and the like.

Pharmaceutical Formulations and Routes of Administration

[0135] Embodiments of the present disclosure include one or more triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives identified herein and formulated with one or more pharmaceutically acceptable excipients, diluents, carriers and/or adjuvants. In addition, embodiments of the present disclosure include such triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives formulated with one or more pharmaceutically acceptable auxiliary substances. In particular, one or more triamino-pyridine derivative and/or the labeled triamino-pyridine derivatives can be formulated with one or more pharmaceutically acceptable excipients, diluents, carriers, and/or adjuvants to provide an embodiment of a composition of the present disclosure.

[0136] A wide variety of pharmaceutically acceptable excipients are known in the art. Pharmaceutically acceptable excipients have been amply described in a variety of publications, including, for example, A. Gennaro (2000) "Remington: The Science and Practice of Pharmacy," 20th edition, Lippincott, Williams, & Wilkins; Pharmaceutical Dosage Forms and Drug Delivery Systems (1999) H. C. Ansel et al., eds., 7.sup.th ed., Lippincott, Williams, & Wilkins; and Handbook of Pharmaceutical Excipients (2000) A. H. Kibbe et al., eds., 3.sup.rd ed. Amer. Pharmaceutical Assoc.

[0137] The pharmaceutically acceptable excipients, such as vehicles, adjuvants, carriers or diluents, are readily available to the public. Moreover, pharmaceutically acceptable auxiliary substances, such as pH adjusting and buffering agents, tonicity adjusting agents, stabilizers, wetting agents and the like, are readily available to the public.

[0138] In an embodiment of the present disclosure, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered to the host using any means capable of resulting in the desired effect. Thus, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be incorporated into a variety of formulations for therapeutic administration. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into pharmaceutical compositions by combination with appropriate, pharmaceutically acceptable carriers or diluents, and may be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants and aerosols.

[0139] In pharmaceutical dosage forms, the inhibiting agent may be administered in the form of its pharmaceutically acceptable salts, or a subject active agent may be used alone or in appropriate association, as well as in combination, with other pharmaceutically active compounds. The following methods and excipients are merely exemplary and are in no way limiting.

[0140] For oral preparations, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be used alone or in combination with appropriate additives to make tablets, powders, granules or capsules, for example, with conventional additives, such as lactose, mannitol, corn starch or potato starch; with binders, such as crystalline cellulose, cellulose derivatives, acacia, corn starch or gelatins; with disintegrators, such as corn starch, potato starch or sodium carboxymethylcellulose; with lubricants, such as talc or magnesium stearate; and if desired, with diluents, buffering agents, moistening agents, preservatives and flavoring agents.

[0141] Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into preparations for injection by dissolving, suspending or emulsifying them in an aqueous or nonaqueous solvent, such as vegetable or other similar oils, synthetic aliphatic acid glycerides, esters of higher aliphatic acids or propylene glycol; and if desired, with conventional additives such as solubilizers, isotonic agents, suspending agents, emulsifying agents, stabilizers and preservatives.

[0142] Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be utilized in aerosol formulation to be administered via inhalation. Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated into pressurized acceptable propellants such as dichlorodifluoromethane, propane, nitrogen and the like.

[0143] Furthermore, embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be made into suppositories by mixing with a variety of bases such as emulsifying bases or water-soluble bases. Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered rectally via a suppository. The suppository can include vehicles such as cocoa butter, carbowaxes and polyethylene glycols, which melt at body temperature, yet are solidified at room temperature.

[0144] Unit dosage forms for oral or rectal administration, such as syrups, elixirs, and suspensions, may be provided wherein each dosage unit, for example, teaspoonful, tablespoonful, tablet or suppository, contains a predetermined amount of the composition containing one or more inhibiting agents. Similarly, unit dosage forms for injection or intravenous administration may comprise the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative in a composition as a solution in sterile water, normal saline or another pharmaceutically acceptable carrier.

[0145] Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be formulated in an injectable composition in accordance with the invention. Typically, injectable compositions are prepared as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. The preparation may also be emulsified or the active ingredient (triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) encapsulated in liposome vehicles in accordance with the present disclosure.

[0146] In an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is formulated for delivery by a continuous delivery system. The term "continuous delivery system" is used interchangeably herein with "controlled delivery system" and encompasses continuous (e.g., controlled) delivery devices (e.g., pumps) in combination with catheters, injection devices, and the like, a wide variety of which are known in the art.

[0147] Mechanical or electromechanical infusion pumps can also be suitable for use with the present disclosure. Examples of such devices include those described in, for example, U.S. Pat. Nos. 4,692,147; 4,360,019; 4,487,603; 4,360,019; 4,725,852; 5,820,589; 5,643,207; 6,198,966; and the like. In general, delivery of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be accomplished using any of a variety of refillable, pump systems. Pumps provide consistent, controlled release over time. In some embodiments, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is in a liquid formulation in a drug-impermeable reservoir, and is delivered in a continuous fashion to the individual.

[0148] In one embodiment, the drug delivery system is an at least partially implantable device. The implantable device can be implanted at any suitable implantation site using methods and devices well known in the art. An implantation site is a site within the body of a subject at which a drug delivery device is introduced and positioned. Implantation sites include, but are not necessarily limited to, a subdermal, subcutaneous, intramuscular, or other suitable site within a subject's body. Subcutaneous implantation sites are used in some embodiments because of convenience in implantation and removal of the drug delivery device.

[0149] Drug release devices suitable for use in the disclosure may be based on any of a variety of modes of operation. For example, the drug release device can be based upon a diffusive system, a convective system, or an erodible system (e.g., an erosion-based system). For example, the drug release device can be an electrochemical pump, osmotic pump, an electroosmotic pump, a vapor pressure pump, or osmotic bursting matrix, e.g., where the drug is incorporated into a polymer and the polymer provides for release of drug formulation concomitant with degradation of a drug-impregnated polymeric material (e.g., a biodegradable, drug-impregnated polymeric material). In other embodiments, the drug release device is based upon an electrodiffusion system, an electrolytic pump, an effervescent pump, a piezoelectric pump, a hydrolytic system, etc.

[0150] Drug release devices based upon a mechanical or electromechanical infusion pump can also be suitable for use with the present disclosure. Examples of such devices include those described in, for example, U.S. Pat. Nos. 4,692,147; 4,360,019; 4,487,603; 4,360,019; 4,725,852, and the like. In general, a subject treatment method can be accomplished using any of a variety of refillable, non-exchangeable pump systems. Pumps and other convective systems are generally preferred due to their generally more consistent, controlled release over time. Osmotic pumps are used in some embodiments due to their combined advantages of more consistent controlled release and relatively small size (see, e.g., PCT published application no. WO 97/27840 and U.S. Pat. Nos. 5,985,305 and 5,728,396). Exemplary osmotically-driven devices suitable for use in the disclosure include, but are not necessarily limited to, those described in U.S. Pat. Nos. 3,760,984; 3,845,770; 3,916,899; 3,923,426; 3,987,790; 3,995,631; 3,916,899; 4,016,880; 4,036,228; 4,111,202; 4,111,203; 4,203,440; 4,203,442; 4,210,139; 4,327,725; 4,627,850; 4,865,845; 5,057,318; 5,059,423; 5,112,614; 5,137,727; 5,234,692; 5,234,693; 5,728,396; and the like.

[0151] In some embodiments, the drug delivery device is an implantable device. The drug delivery device can be implanted at any suitable implantation site using methods and devices well known in the art. As noted herein, an implantation site is a site within the body of a subject at which a drug delivery device is introduced and positioned. Implantation sites include, but are not necessarily limited to a subdermal, subcutaneous, intramuscular, or other suitable site within a subject's body.

[0152] In some embodiments, an active agent is delivered using an implantable drug delivery system, e.g., a system that is programmable to provide for administration of the agent. Exemplary programmable, implantable systems include implantable infusion pumps. Exemplary implantable infusion pumps, or devices useful in connection with such pumps, are described in, for example, U.S. Pat. Nos. 4,350,155; 5,443,450; 5,814,019; 5,976,109; 6,017,328; 6,171,276; 6,241,704; 6,464,687; 6,475,180; and 6,512,954. A further exemplary device that can be adapted for the present disclosure is the Synchromed infusion pump (Medtronic).

[0153] Suitable excipient vehicles for the inhibiting agent are, for example, water, saline, dextrose, glycerol, ethanol, or the like, and combinations thereof. In addition, if desired, the vehicle may contain minor amounts of auxiliary substances such as wetting or emulsifying agents or pH buffering agents. Methods of preparing such dosage forms are known, or will be apparent upon consideration of this disclosure, to those skilled in the art. See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., 17th edition, 1985. The composition or formulation to be administered will, in any event, contain a quantity of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative adequate to achieve the desired state in the subject being treated.

[0154] Compositions of the present disclosure include those that comprise a sustained-release or controlled release matrix. In addition, embodiments of the present disclosure can be used in conjunction with other treatments that use sustained-release formulations. As used herein, a sustained-release matrix is a matrix made of materials, usually polymers, which are degradable by enzymatic or acid-based hydrolysis or by dissolution. Once inserted into the body, the matrix is acted upon by enzymes and body fluids. A sustained-release matrix desirably is chosen from biocompatible materials such as liposomes, polylactides (polylactic acid), polyglycolide (polymer of glycolic acid), polylactide co-glycolide (copolymers of lactic acid and glycolic acid), polyan hydrides, poly(ortho)esters, polypeptides, hyaluronic acid, collagen, chondroitin sulfate, carboxcylic acids, fatty acids, phospholipids, polysaccharides, nucleic acids, polyamino acids, amino acids such as phenylalanine, tyrosine, isoleucine, polynucleotides, polyvinyl propylene, polyvinylpyrrolidone and silicone. Illustrative biodegradable matrices include a polylactide matrix, a polyglycolide matrix, and a polylactide co-glycolide (co-polymers of lactic acid and glycolic acid) matrix.

[0155] In another embodiment, the pharmaceutical composition of the present disclosure (as well as combination compositions) can be delivered in a controlled release system. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative may be administered using intravenous infusion, an implantable osmotic pump, a transdermal patch, liposomes, or other modes of administration. In one embodiment, a pump may be used (Sefton (1987). CRC Crit. Ref Biomed. Eng. 14:201; Buchwald et al. (1980). Surgery 88:507; Saudek et al. (1989). N. Engl. J. Med. 321:574). In another embodiment, polymeric materials are used. In yet another embodiment a controlled release system is placed in proximity of the therapeutic target thus requiring only a fraction of the systemic dose. In yet another embodiment, a controlled release system is placed in proximity of the therapeutic target, thus requiring only a fraction of the systemic. Other controlled release systems are discussed in the review by Langer (1990). Science 249:1527-1533.

[0156] In another embodiment, the compositions of the present disclosure (as well as combination compositions separately or together) include those formed by impregnation of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative described herein into absorptive materials, such as sutures, bandages, and gauze, or coated onto the surface of solid phase materials, such as surgical staples, zippers and catheters to deliver the compositions. Other delivery systems of this type will be readily apparent to those skilled in the art in view of the instant disclosure.

Dosages

[0157] Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered to a host in one or more doses. Those of skill will readily appreciate that dose levels can vary as a function of the specific triamino-pyridine derivative and/or the labeled triamino-pyridine derivative administered, the severity of the symptoms and the susceptibility of the subject to side effects. Preferred dosages for a given compound are readily determinable by those of skill in the art by a variety of means.

[0158] In an embodiment, multiple doses of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative are administered. The frequency of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can vary depending on any of a variety of factors, e.g., severity of the symptoms, and the like. For example, in an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered once per month, twice per month, three times per month, every other week (qow), once per week (qw), twice per week (biw), three times per week (tiw), four times per week, five times per week, six times per week, every other day (god), daily (qd), twice a day (qid), or three times a day (tid). As discussed above, in an embodiment, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered continuously.

[0159] The duration of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative, e.g., the period of time over which the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative is administered, can vary, depending on any of a variety of factors, e.g., patient response, etc. For example, the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered over a period of time of about one day to one week, about two weeks to four weeks, about one month to two months, about two months to four months, about four months to six months, about six months to eight months, about eight months to 1 year, about 1 year to 2 years, or about 2 years to 4 years, or more.

Routes of Administration

[0160] Embodiments of the present disclosure provide methods and compositions for the administration of the active agent (e.g., triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) to a host (e.g., a human) using any available method and route suitable for drug delivery, including in vivo and ex vivo methods, as well as systemic and localized routes of administration.

[0161] Routes of administration include intranasal, intramuscular, intratracheal, subcutaneous, intradermal, topical application, intravenous, rectal, nasal, oral, and other enteral and parenteral routes of administration. Routes of administration may be combined, if desired, or adjusted depending upon the agent and/or the desired effect. An active agent (e.g., triamino-pyridine derivative and/or the labeled triamino-pyridine derivative) can be administered in a single dose or in multiple doses.

[0162] Embodiments of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can be administered to a host using available conventional methods and routes suitable for delivery of conventional drugs, including systemic or localized routes. In general, routes of administration contemplated by the disclosure include, but are not limited to, enteral, parenteral, or inhalational routes.

[0163] Parenteral routes of administration other than inhalation administration include, but are not limited to, topical, transdermal, subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intrasternal, and intravenous routes, i.e., any route of administration other than through the alimentary canal. Parenteral administration can be conducted to effect systemic or local delivery of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative. Where systemic delivery is desired, administration typically involves invasive or systemically absorbed topical or mucosal administration of pharmaceutical preparations.

[0164] The triamino-pyridine derivative and/or the labeled triamino-pyridine derivative can also be delivered to the subject by enteral administration. Enteral routes of administration include, but are not limited to, oral and rectal (e.g., using a suppository) delivery.

[0165] Methods of administration of the triamino-pyridine derivative and/or the labeled triamino-pyridine derivative through the skin or mucosa include, but are not limited to, topical application of a suitable pharmaceutical preparation, transdermal transmission, injection and epidermal administration. For transdermal transmission, absorption promoters or iontophoresis are suitable methods. Iontophoretic transmission may be accomplished using commercially available "patches" that deliver their product continuously via electric pulses through unbroken skin for periods of several days or more.

EXAMPLES

Example 1

[0166] Compounds disclosed herein can be represented by one of the following general structures VI-XV. The lists of substituents for the R.sup.1-R.sup.8 and X.sup.2 groups are shown in Tables 1-10 and are described above.

TABLE-US-00001 TABLE 1 ##STR00052## VI

TABLE-US-00002 TABLE 2 ##STR00053## VII

TABLE-US-00003 TABLE 3 ##STR00054## VIII

TABLE-US-00004 TABLE 4 ##STR00055## IXa

TABLE-US-00005 TABLE 4 ##STR00056## IXb

TABLE-US-00006 TABLE 5 ##STR00057## X

TABLE-US-00007 TABLE 6 ##STR00058## XI

TABLE-US-00008 TABLE 7 ##STR00059## XII

TABLE-US-00009 TABLE 8 ##STR00060## XIII

TABLE-US-00010 TABLE 9 ##STR00061## XIV

TABLE-US-00011 TABLE 10 ##STR00062## XV

Example 2

[0167] Compounds of general structure VI are shown in Table 1 and may be synthesized by the sequence shown in Scheme 1. The R.sup.1--N--R.sup.2 groups contained in these structures can be purchased commercially or prepared according to known literature procedures. Chen, et al. J. Labelled. Cpd. Radiopharm. (1999) 42:Suppl. 1:S400; Hsin, et al. Bioorg. Med. Chem. Lett. (2000) 10:707; Hsin, J. Labelled Cpd. Radiopharm. (2000) 43:899; Martarello, et al. Nuc. Med. Biol. (2001) 28:187; Dubowchik, et al. Bioorg. Med. Chem. Lett. (2004) 14:3147; Singh, et al. Eur. J. Org. Chem. (2007) 8:1369.

[0168] Compounds which contain a bulky ortho-substituent will have reduced rotation around the bond connecting the aniline ring to the central core and will experience atropisomerism. Eliel, et al. Stereochemistry of Organic Compounds. (1994) John Wiley & Sons, Inc.: NY.

##STR00063##

[0169] Atropisomerism can be observed by .sup.1H NMR (FIG. 1) due to diastereotopic splitting of the protons on the .alpha.-carbon of the acetamide group. Nelson, J. Nuclear Magnetic Resonance Spectroscopy (2003) Pearson Education, Inc.: Upper Saddle River, N.J. Atropisomeric compounds can be separated by chiral HPLC or chiral crystallization. Shi, et al. J. Chromatogr. A (2005) 1078:67; Anand, et al. Tetrahedron (2007) 63:5236; Erol, et al. J. Org. Chem. (2007) 72:2494; Vrudhula, J. Med. Chem. (2007) 50:1050.

Example 3

[0170] Compounds of general structure VII (Table 2) and VIII (Table 3) may be prepared as shown in Schemes 2 and 3, respectively.

##STR00064##

##STR00065##

Example 4

[0171] Compounds of general structure XVI and XVII (derived from VI) which contain a halogen (Br, I) or other group suitable for coupling in the ortho- or para-positions (X.sup.1) can be coupled to (Z)-1,2-bis(trimethylstannyl)ethene or tributyl(vinyl)tin (for X.sup.2=H compounds) to give the vinyl compounds (X.sup.2=H, SnMe.sub.3) and will provide both the cis and trans isomers when X.sup.2=SnMe.sub.3 (Schemes 2 and 3). Mitchell, et al. J. Organomet. Chem. (1986) 304:257; Blough, et al. J. Med. Chem. (2002) 45:4029; Stehouwer, et al. J. Med. Chem. (2006) 49:6760. The vinyltin compounds (X.sup.2=SnMe.sub.3) can then be converted to the corresponding vinylhalide compounds (X.sup.2=Br, I) by halo-destannylation. Stehouwer, at al. J. Med. Chem. (2006) 49:6760. This halo-destannylation reaction can also be used for radiolabeling. (Scheme 15). Goodman, et al. J. Med. Chem. (2003) 46:925; Plisson, et al. J. Med. Chem. (2004) 47:1122.

Example 5

[0172] The aniline ring of XVI can be linked to the central core to give compounds of general structure IX (Table 4) as shown in Scheme 4. Coupling of XVI with (Z)-3-(tri-n-butylstannyl)-2-propen-1-ol, (Z)-4-(tri-n-butylstannyl)-3-buten-1-ol, or (7)-5-(tri-n-butylstannyl)-4-penten-1-ol, provides the intermediate alcohol XVIII which can then be converted to the tosylate (or other appropriate leaving group) XIX. Leusink, et al. J. Organometal. Chem. (1967) 9:285; Jung, et al. Tetrahedron Lett. (1982) 23:3851; Miura, et al. J. Org. Chem. (2003) 68:8730; Dussault, J. Am. Chem. Soc. (1998) 120:7133. Treatment of XIX with a strong base such as a metal hydride or metal amide will generate an enolate which will then displace the leaving group and provide compounds IX. Alternatively, XVI can be treated first with a strong base such as a metal hydride or metal amide to provide an enolate which can then be alkylated with a vinyltin-alkane containing a leaving group (halogen, alkyl sulfonate, etc.) to give XX. Subjection of XX to metal-catalyzed coupling conditions will then provide compounds IX.

##STR00066##

Example 6

[0173] Compounds of general structure X (Table 5) can be synthesized as shown in Scheme 5. Reaction of compound IV with a haloacetyl halide (chloroacetyl chloride, bromoacetyl bromide, bromoacetyl chloride, etc.) or a haloacetic anhydride (chloroacetic anhydride, bromoacetic anhydride, iodoacetic anhydride) will afford compound XXI which can then be cyclized under conditions similar to that employed to prepare VI from V (Scheme 1) to afford compounds X. Placing the carbonyl group in this position creates additional steric hindrance between the aniline ring and central core and will, therefore, produce atropisomers as mentioned above.

##STR00067##

Example 7

[0174] Compounds of general structure XI (Table 6) and XII (Table 7) are prepared from compounds XXII and XXIII, respectively, by the same method with which compounds VII and VIII are prepared from XVI and XVII, respectively (Schemes 2 and 3).

##STR00068##

Example 8

[0175] Compounds of general structure XIII (Table 8) are prepared as shown in Scheme 6. Reduction of III affords XXIV which can be reacted with a haloacetyl halide (chloroacetyl chloride, bromoacetyl bromide, bromoacetyl chloride, etc.) or a haloacetic anhydride (chloroacetic anhydride, bromoacetic anhydride, iodoacetic anhydride) to give compound XXV as well as compounds XXVI and XXVII (see below). Reaction of XXV with a benzyl amine derivative affords XXVIII (and also XXVI and XXVII as side products) which can be cyclized by heating in a high-boiling alcohol (including, but not limited to, n-butanol, isoamyl alcohol, cyclohexanol) in the presence of base to afford XIII. As a specific example of XIII, FIG. 2 shows the X-ray crystal structure of compound 8374.HCl (Table 8, R.sup.1=Bu, R.sup.2=Et, R.sup.6=H, R.sup.7=H).

##STR00069##

Example 9

[0176] Scheme 7 demonstrates a specific example of the synthesis of compounds of type XXVI and XXVII. Reaction of XXIX with chloroacetic anhydride and diisopropylethylamine (i-Pr.sub.2Net) in CHCl.sub.3 affords compound XXX in which the nitrogen lone pair can attack the chloro-acetamide group to give the proposed transient compound XXXI. A chloride anion can then attack either the butyl or ethyl group of XXXI to give compounds XXXIII and XXXII, respectively. The X-ray crystal structures of XXXII and XXXIII are shown in FIGS. 3 and 4, respectively. Compounds XXXII and XXXIII can also be prepared directly by heating XXX in an appropriate solvent in the presence of base.

##STR00070##

Example 10

[0177] Compounds of general structures XIV (Table 9) and XV (Table 10) can be prepared from compounds of type XXVI and XXVII as shown in Scheme 8. Reaction of XXVI/XXVII with aniline derivatives by known literature methods will provide compound XXXIV which can be reacted with a dihaloalkane (CH.sub.2X.sub.2, XCH.sub.2CH.sub.2X, etc.) or other alkane with suitable leaving groups (e.g. alkylsulfonate esters) to afford compound XIV. Guo, et al. J. Med. Chem. (2005) 48:5104; Gentile, et al. Bioorg. Med. Chem. Lett. (2007) 17:5218.

Example 11

[0178] Compound XXXIV can also be reacted with phosgene, triphosgene, diethylcarbonate, etc. to afford compound XV. Compounds XIV and XV can be N-dealkylated (R.sup.8) to afford compound XXXV. Guo, et al. J. Med. Chem. (2005) 48:5104; Beck, et al. Bioorg. Med. Chem. Lett. (1999) 9:967; He, et al. J. Med. Chem. (2000) 43:449. Alternatively, if R.sup.8=Bn (obtained by reacting I with N-benzylmethylamine and then carrying the product through the synthetic sequences shown above) the N-benzyl group can be removed by hydrogenolysis on Pd/C to afford XXXV. Compound XXXV can then be N-alkylated to afford additional derivatives or radiolabeled compounds (see below). Guo, et al. J. Med. Chem. (2005) 48:5104; Gross, et al. J. Med. Chem. (2005) 48:5780.

##STR00071##

Example 12

[0179] The radiosynthetic methods for preparing these radiolabeled derivatives are summarized below. Many of the radiosyntheses can be accomplished by nucleophilic SN.sup.2 reactions such as O- and N-alkylations (Schemes 9 and 10) which are common radiolabeling methods reported in the literature. Kumar, et al. Bioorg. Med. Chem. (2006) 14:4029; Sullivan, Nuc. Med. Biol. (2007) 34:353; Scott, et al. J. Label. Compd. Radiopharm. (2007) 50:Supplement 1:S124; Stehouwer, et al. J. Med. Chem. (2005) 48:7080. Reaction with [.sup.11C]methyl iodide or [.sup.11C]methyl triflate allows for the introduction of a [.sup.11C]-radiolabel while reaction with a [.sup.18F]fluoroalkane containing a leaving group (e.g. [.sup.18F]fluoromethyl tosylate, [.sup.18F]fluoroethyl tosylate, [.sup.18F]fluoroethyl brosylate, [.sup.18F]fluoropropyl brosylate, (E/Z)-[.sup.18F]-1-fluoro-4-tosyl-2-butene, etc.) allows for the introduction of an [.sup.18F]-radiolabel. [.sup.18F]Fluoromethyl derivatives can be prepared from ditosylmethane derivatives as shown in Scheme 11. Reaction of diiodomethane, diiodomethane-D.sub.2, or dibromodifluoromethane with silver tosylate will afford ditosylates XXXVI which can then be reacted with .sup.18F to give the [.sup.18F]-alkylating agents XXXVII. Emmons, et al. J. Am. Chem. Soc. (1953) 75:2257; Neal, et al. J. Label. Compd. Radiopharm. (2003) 46:Supplement 1:S198. Alternatively, .sup.16FCH.sub.2Br can be prepared from dibromomethane and .sup.18FCBrF.sub.2 can be prepared from dibromodifluoromethane. Eskola, et al. J. Label. Compd. Radiopharm. (1999) 42:Supplement 1:S543; Viljanen, J. Label. Compd. Radiopharm. 2003, 46, Supplement 1, S219. Compounds XXXVII can then be used as shown in Schemes 9 and 10. Compounds containing the --OCF.sub.2.sup.18F group can also be prepared from chlorodifluoromethoxy precursors. Hagooly, et al. Eur. J. Org. Chem. (2008) 17:2875.

##STR00072##

##STR00073##

##STR00074##

Example 13

[0180] Employing .sup.18F as a nucleophile is another common literature method for radiolabeling. As shown in Scheme 12, displacing a leaving group (halogen, alkyl sulfonate, etc.) from an alkyl group allows for the creation of an [.sup.18F]alkyl substituent. Kim, et al. J. Am. Chem. Soc. (2006) 128:16394; Hsin, et al. Bioorg. Med. Chem. Lett. (2000) 10:707; Hsin, et al. J. Labelled Cpd. Radiopharm. (2000) 43:899; Martarello, et al. Nuc. Med. Biol. (2001) 28:187. [.sup.18F]Fluorination of an aromatic ring can be achieved by displacing a halide, nitro group, trialkylammonium halide or triflate, or an iodonium salt, as shown in Scheme 13. Oya, et al. J. Med. Chem. (2002) 45:4716; Mach, et al. Nucl. Med. Biol. (1993) 20:777; Kuhnast, et al. J. Label. Compd. Radiopharm. (2008) 51:336; Koser, et al. J. Org. Chem. (1980) 45:1542; Koser, et al. J. Org. Chem. (1980) 45:1543; Pike, et al. J. Chem. Soc., Perkin Trans. 1 (1999) 245; Ross, et al. J. Am. Chem. Soc. (2007) 129:8018.

##STR00075##

##STR00076##

Example 14

[0181] Coupling reactions with [.sup.11C]methyl iodide or [.sup.11C]methyl triflate can be employed to connect a [.sup.11C]radiolabel to an aromatic ring as shown in Scheme 14. Suzuki, et al. Chem. Eur. J. (1997) 3:2039; Bjorkman, J. Label. Compd. Radiopharm. (2000) 43:1327; Karimi, et al. J. Label. Compd. Radiopharm. (2002) 45:423. Halodestannylation reactions with a vinyl stannane are a method of preparing radiolabeled vinyl halides and an example is shown in Scheme 15. Tamagnan, NeuroImage (2006) 31:T131; Plisson, J. Med. Chem. (2004) 47:1122; Goodman, J. Med. Chem. (2003) 46:925.

##STR00077##

##STR00078##

[0182] Thus, Schemes 9-15 demonstrate generation of the radiolabeled versions of the compounds listed in Tables 1-10 (excluding the radiolabeling precursors that are listed in those tables) using known literature procedures. Disclosed herein are the radiolabeling precursors (those listed in as well as those not listed in Tables 1-10) that are necessary to prepare these radiolabeled compounds (e.g. R.sup.1 or R.sup.2=alkyl containing a leaving group) as well as the intermediates that are necessary to prepare these radiolabeling precursors (e.g., R.sup.1 or R.sup.2=alkyl containing a hydroxyl group for conversion to a leaving group).

Example 15

[0183] "Click-chemistry" is the Cu(I)-catalyzed 1,3-dipolar cycloaddition of a terminal alkyne and an azide (Scheme 16) and this method has been used successfully for radio-labeling PET tracers (Schemes 17 and 18). Kolb, et al. Angew. Chem. Int. Ed. (2001) 40:2004; Rostovtsev, et al. Angew. Chem. Int. Ed. (2002) 41:2596; Kolb, et al. Drug Discovery Today (2003) 8:1128; Wang, et al. Green Chem. (2008) 10:452; Marik, et al. Tetrahedron Lett. (2006) 47:6681; Glaser, et al. Bioconjugate Chem. (2007) 18:989; Kuhnast, et al. J. Label. Compd. Radiopharm. (2008) 51:336; Smith, et al. J. Med. Chem. (2008) 51:8057.

##STR00079##

##STR00080##

##STR00081##

[0184] Accordingly, the compounds with general structure XXXVIII (Scheme 19) can be reacted under click chemistry conditions to give compounds of general structures XXXIX and XXXX, where R.sup.12=H, OH, O-alkyl, alkyl, halogen, haloalkyl, heteroalkyl; R.sup.13=H, alkyl, haloalkyl, heteroalkyl; and where R.sup.1 and R.sup.2 are as defined in Tables 1-8; and the derivatives of compounds VI-XIII where R.sup.1=propargyl derivatives (example: compound XXXXI, Scheme 20) and where R.sup.2-R.sup.7, X.sup.2, n=as defined in Tables 1-8; and also the derivatives of compounds XIV and XV where R.sup.8=propargyl derivatives, and R.sup.3 and n are as defined in Tables 9 and 10. Furthermore, triazole products that can result from performing click-chemistry on these compounds (e.g., compounds XXXXII and XXXXIII).

##STR00082##

##STR00083##

Example 16

Specific Examples

[0185] Pyrido[2,3-b]pyrazin-2-ones of type VI (Table 1) were synthesized according to the procedure reported by Dzierba, et al. (J. Med. Chem. 2004, 47, 5783-5790) as shown in Scheme 21. 4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (J. Med. Chem. 2004, 47, 5783-5790) was reacted neat with an aniline derivative to give the aniline-substituted nitro-pyridines 17217, 17218, and 17219. These were deprotonated with NaH and reacted with ethyl iodoacetate to give compounds 17220, 17221, and 17222 which were reductively cyclized to afford the target compounds 185, 188, and 191. Compounds 185, 188, and 191 were screened for binding affinity vs. [.sup.125I]sauvagine (Mol. Pharmacol. 1996, 50, 679-686) at the CRF-1 receptor using transfected HEK293T/17 cells expressing the CRF-1 receptor according to standard in vitro competitive binding procedures. (Mol. Pharmacol. 2003, 63, 751-765; Peptides 2003, 24, 1881-1897; Peptides 2005, 26, 457-470) The binding affinities of compounds 185, 188, and 191 are shown in Table 11 along with the binding affinities of sauvagine and R121919, (Neuropsychopharmacology 2002, 27, 194-202; J. Med. Chem. 2004, 47, 4787-4798) for comparison. Compounds 185, 188, and 191 all have a high affinity for the CRF-1 receptor, only slightly reduced from that found for R121919, indicating that these compounds are potential antagonists of the CRF-1 receptor and also may potentially be employed as imaging agents.

[0186] Scheme 22 shows the conversion of bromo-compound 185 to the trimethylstannyl-compound 190, which was accomplished by reacting 185 with hexamethylditin in the presence of catalytic Pd. Compound 190 can serve as the radiolabeling precursor to prepare [.sup.11C]191 (Scheme 14). The bulkiness of the trimethylstannyl group of 190 restricts the rotation of the aniline ring resulting in atropisornerism as demonstrated by the diastereotopic proton splitting pattern in the .sup.1H NMR spectrum (FIG. 1).

##STR00084##

TABLE-US-00012 TABLE 11 CRF-1 Receptor Binding Affinities (vs. [.sup.125I] Sauvagine). K.sub.i (nM) Sauvagine R121919 185 188 191 0.45 .+-. 0.05 4.1 .+-. 0.4 6.2 .+-. 1.4 5.7 .+-. 0.3 9.1 (n = 5) (n = 10) (n = 2) (n = 2) (n = 1)

##STR00085##

[0187] FIG. 1 illustrates the .sup.1H NMR spectra (600 MHz, CDCl.sub.3) of compounds 191, 185, and 190 demonstrating the existence of atropisomerism due to restricted rotation of the aniline ring.

[0188] Compounds of type XIII (Table 8) were synthesized as shown in Scheme 23. 4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (J. Med. Chem. 2004, 47, 5783-5790) was reduced with SnCl.sub.2 to give the substituted aminopyridine XXIX. Reaction of XXIX with chloroacetic anhydride afforded chloroacetamido-pyridine XXX along with compounds XXXII and XXXIII as side-products (see Scheme 7). Chloroacetamido-pyridine XXX was then reacted with benzylamine or a benzylamine derivative to give compounds 17223-17227 (along with compounds XXXII and XXXIII as side-products). Compounds 17223-17225 were then cyclized to compounds 8374-8376, respectively, by stirring in refluxing nBuOH in the presence of base, whereas compounds 17226 and 17227 were cyclized to compounds 8404 and 8409, respectively, by stirring in refluxing cyclohexanol in the presence of base. Compound 8374 was converted to the HCl salt by adding HCl/EtOEt to a solution of 8374 in EtOEt. The X-ray crystal structure of 8374.HCl is shown in FIG. 2.

##STR00086##

[0189] FIG. 2 illustrates the thermal ellipsoid representation of the X-ray crystal structure of 8374.HCl.

TABLE-US-00013 TABLE 12 Crystal data and structure refinement for 8374.cndot.HCl. Empirical formula C.sub.21H.sub.29ClN.sub.4O Formula weight 388.93 Temperature 173(2) K Wavelength 1.54178 .ANG. Crystal system Monoclinic Space group P2(1)/c Unit cell dimensions a = 11.5688(9) .ANG. .alpha. = 90.degree.. b = 12.7793(11) .ANG. .beta. = 93.995(4).degree.. c = 14.2458(9) .ANG. .gamma. = 90.degree.. Volume 2101.0(3) .ANG..sup.3 Z 4 Density (calculated) 1.230 Mg/m.sup.3 Absorption coefficient 1.741 mm.sup.-1 F(000) 832 Crystal size 0.24 .times. 0.19 .times. 0.07 mm.sup.3 Theta range for data collection 3.83 to 65.21.degree.. Index ranges -12 <= h <= 13, -13 <= k <= 14, -16 <= l <= 16 Reflections collected 9738 Independent reflections 3234 [R(int) = 0.0578] Completeness to theta = 65.21.degree. 89.8% Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.8879 and 0.6801 Refinement method Full-matrix least-squares on F.sup.2 Data/restraints/parameters 3234/0/256 Goodness-of-fit on F.sup.2 1.035 Final R indices [I > 2sigma(I)] R1 = 0.0444, wR2 = 0.1113 R indices (all data) R1 = 0.0728, wR2 = 0.1331 Extinction coefficient 0.0008(2) Largest diff. peak and hole 0.310 and -0.260 e..ANG..sup.-3

[0190] Compounds XXXII and XXXIII can also be prepared by reacting compound XXIX with bromoacetic anhydride. The X-ray crystal structures of XXXII and XXXIII are shown in FIGS. 3 and 4, respectively, and the crystal data is shown in Tables 13 and 14, respectively.

[0191] FIG. 3 illustrates the thermal ellipsoid representation of the X-ray crystal structure of XXXII.

TABLE-US-00014 TABLE 13 Crystal data and structure refinement for XXXII. Empirical formula C12 H14.35 Cl N3 O1.35 Formula weight 257.66 Temperature 173(2) K Wavelength 1.54178 .ANG. Crystal system Triclinic Space group P-1 Unit cell dimensions a = 7.2453(17) .ANG. .alpha. = 69.509(14).degree.. b = 9.187(2) .ANG. .beta. = 86.852(12).degree.. c = 9.997(2) .ANG. .gamma. = 80.726(14).degree.. Volume 615.2(3) .ANG..sup.3 Z 2 Density (calculated) 1.391 Mg/m.sup.3 Absorption coefficient 2.685 mm.sup.-1 F(000) 270 Crystal size 0.33 .times. 0.31 .times. 0.30 mm.sup.3 Theta range for data collection 4.72 to 65.80.degree.. Index ranges -8 <= h <= 8, -9 <= k <= 10, -11 <= l <= 11 Reflections collected 4412 Independent reflections 1700 [R(int) = 0.0383] Completeness to theta = 65.80.degree. 79.7% Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.4997 and 0.4711 Refinement method Full-matrix least-squares on F.sup.2 Data/restraints/parameters 1700/0/166 Goodness-of-fit on F.sup.2 1.235 Final R indices [I > 2sigma(I)] R1 = 0.0751, wR2 = 0.2179 R indices (all data) R1 = 0.0949, wR2 = 0.2683 Extinction coefficient 0.011(4) Largest diff. peak and hole 0.608 and -0.566 e..ANG..sup.-3

[0192] FIG. 4 illustrates the thermal ellipsoid representation of the X-ray crystal structure of XXXIII.

TABLE-US-00015 TABLE 14 Crystal data and structure refinement for XXXIII. Empirical formula C10 H12 Cl N3 O Formula weight 225.68 Temperature 173(2) K Wavelength 1.54178 .ANG. Crystal system Monoclinic Space group P2(1)/n Unit cell dimensions a = 6.9906(5) .ANG. .alpha. = 90.degree.. b = 9.0272(7) .ANG. .beta. = 101.034(4).degree.. c = 16.7567(11).ANG. .gamma. = 90.degree.. Volume 1037.89(13) .ANG..sup.3 Z 4 Density (calculated) 1.444 Mg/m.sup.3 Absorption coefficient 3.072 mm.sup.-1 F(000) 472 Crystal size 0.39 .times. 0.28 .times. 0.04 mm.sup.3 Theta range for data collection 5.38 to 65.54.degree.. Index ranges -6 <= h <= 7, -9 <= k <= 9, -17 <= l <= 19 Reflections collected 4339 Independent reflections 1476 [R(int) = 0.0235] Completeness to theta = 65.54.degree. 82.2% Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.9001 and 0.3805 Refinement method Full-matrix least-squares on F.sup.2 Data/restraints/parameters 1476/0/142 Goodness-of-fit on F.sup.2 1.047 Final R indices [I > 2sigma(I)] R1 = 0.0327, wR2 = 0.0887 R indices (all data) R1 = 0.0337, wR2 = 0.0899 Largest diff. peak and hole 0.206 and -0.217 e..ANG..sup.-3

Experimental

[0193] General.

[0194] NMR spectra were obtained on Varian Unity and Inova spectrometers at the specified frequencies. .sup.1H chemical shifts are referenced to internal TMS or residual CHCl.sub.3 (7.26 ppm) and .sup.13C chemical shifts are referenced to CDCl.sub.3 (77.23 ppm). Solvents were purchased from VWR and had originated from EMD or Burdick & Jackson. Anhydrous solvents (100-mL septum-capped bottles) were purchased from Aldrich. TLC plates used were EMD glass-backed Silica Gel 60 F.sub.254, 20.times.20 cm, 250 .mu.m. Preparatory TLC plates used were Analtech Uniplate Silica Gel GF 20.times.20 cm, 2000 .mu.m. Silica gel used was EMD Silica Gel 60, 40-63 .mu.m. Radial chromatography was performed with a Harrison Research Chromatotron. Semi-preparatory HPLC: Waters XTerra Prep RP.sub.13, 5 .mu.m, 19.times.100 mm+guard cartridge (19.times.10 mm). Analytical HPLC: Waters NovaPak 3.9.times.150 mm. HRMS was performed by the Emory University Mass Spectrometry Center. X-ray diffraction data collection and structure determination was performed by the Emory University X-ray Crystallography Center.

4-(2-Bromo-4-methylphenyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyr- ido[2,3-b]pyrazin-2-one (185)

[0195] {(2-Bromo-4-methylphenyl)-[4-(butylethylamino)-6-methyl-3-nitropyri- din-2-yl]amino}acetic acid ethyl ester (0.33 g, 6.50.times.10.sup.-4 mol), Fe.degree. (0.36 g, 6.45 mmol, 9.9 equiv.), conc. HCl.sub.(aq) (0.85 mL, 10.2 mmol, 15.7 equiv.), EtOH (15 mL), and boiling chips were heated at reflux under Ar.sub.(g) for 16 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown residue. To the residue was added CH.sub.2Cl.sub.2 (50 mL) and a suspension of EDTA.2Na.sup.+.2H.sub.2O (2.96 g, 7.95 mmol, 1.2 equiv. Fe.sup.0) in H.sub.2O (50 mL). The mixture was stirred at rt for 35 min, cooled to 0.degree. C., and neutralized with conc. NH.sub.4OH.sub.(aq). The layers were separated, the aqueous layer was extracted with CH.sub.2Cl.sub.2 (20 mL.times.2), and the combined CH.sub.2Cl.sub.2 layers were dried over MgSO.sub.4. The solvent was removed to give a yellow-brown oil that was vacuum flash chromatographed on silica (40 mm h.times.43 mm i.d.): CH.sub.2Cl.sub.2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 90:8:2 (100 mL), 75:20:5 (150 mL) to afford a colorless syrup that was further purified by radial chromatography (2 mm silica): hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (200 mL), 90:8:2 (50 mL), 75:20:5 (100 mL) to give 0.23 g (82%) of a sticky, white foam: TLC R.sub.f=0.36 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt.sub.3); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.92 (br s, 1H), 7.48 (s, 1H), 7.24 (d, 1H, J=8.4 Hz), 7.18 (d, 1H, J=8.4 Hz), 6.35 (s, 1H), 4.38 and 4.32 (2 overlapping br s, 2H), 2.98 (q, 2H, J=7.2 Hz), 2.91 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 2.20 (s, 3H), 1.40 (m, 2H), 1.29 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

8-(Butylethylamino)-4-(2-methyl-4-bromophenyl)-6-methyl-3,4-dihydro-1H-pyr- ido[2,3-b]pyrazin-2-one (188)

[0196] {(2-Methyl-4-bromophenyl)-[4-(butylethylamino)-6-methyl-3-nitropyri- din-2-yl]amino}acetic acid ethyl ester (0.24 g, 4.73.times.10.sup.-4 mol), Fe.sup.0 (0.37 g, 6.63 mmol, 14.0 equiv.), conc. HCl.sub.(aq) (0.60 mL, 7.2 mmol, 15.2 equiv.), EtOH (15 mL), and boiling chips were heated at reflux under Ar.sub.(g) for 16 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown residue. To the residue was added CH.sub.2Cl.sub.2 (40 mL) and a suspension of EDTA.2Na.sup.+.2H.sub.2O (2.71 g, 7.28 mmol, 1.1 equiv. Fe.sup.0) in H.sub.2O (40 mL). The mixture was stirred at rt for 35 min, cooled to 0.degree. C., and neutralized with conc. NH.sub.4OH.sub.(aq). The layers were separated, the aqueous layer was extracted with CH.sub.2Cl.sub.2 (20 mL.times.2), and the combined CH.sub.2Cl.sub.2 layers were dried over MgSO.sub.4. The solvent was removed to give a colorless syrup that was vacuum flash chromatographed on silica (40 mm h.times.43 mm i.d.): CH.sub.2Cl.sub.2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (100 mL) 90:8:2 (100 mL), 75:20:5 (150 mL) to afford a colorless syrup that was further purified by radial chromatography (2 mm silica): hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (300 mL), 90:8:2 (100 mL) to give 0.16 g (78%) of a white foam: TLC R.sub.f=0.31 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt.sub.3); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.89 (br s, 1H), 7.41 (s, 1H), 7.38 (d, 1H, J=8.4 Hz), 7.09 (d, 1H, J=8.4 Hz), 6.36 (s, 1H), 4.30 (br s, 2H), 2.99 (q, 2H, J=7.2 Hz), 2.92 (t, 2H, J=7.2 Hz), 2.21 (s, 3H), 2.07 (s, 3H), 1.40 (m, 2H), 1.30 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

8-(Butylethylamino)-6-methyl-4-(2-trimethylstannyl-4-methylphenyl)-3,4-dih- ydro-1H-pyrido[2,3-b]pyrazin-2-one (190)

[0197] 4-(2-Bromo-4-methylphenyl)-8-(butylethylamino)-6-methyl-3,4-dihydro- -1H-pyrido[2,3-b]pyrazin-2-one (0.17 g, 3.94.times.10.sup.-4 mol), hexamethylditin (0.50 g, 1.53 mmol, 3.9 equiv.), Pd(PPh.sub.3).sub.4 (48 mg, 4.15.times.10.sup.-5 mol, 0.1 equiv), and anhydrous toluene (25 mL) were stirred at reflux under Ar.sub.(g) for 16 h. The reaction mixture was cooled to rt, poured onto dry silica (40 mm h.times.43 mm i.d.), and eluted under vacuum: CH.sub.2Cl.sub.2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (100 mL), 90:8:2 (100 mL), 75:20:5 (150 mL) to give an off-white foam (0.16 g). Purification by preparatory-TLC (20.times.20 cm, 2 mm thickness, 90:8:2 v/v/v hexanes/EtOAc/NEt.sub.3.times.3) afforded recovered starting material (53 mg, 31%) and the trimethylstannyl target compound (86 mg) which was further purified by radial chromatography (1 mm silica): hexanes/EtOAc/NEt.sub.3 v/v/v 98:1:1 (180 mL), 95:4:1 (100 mL) to afford a pure fraction (22 mg) and an impure fraction that was further purified by preparatory-TLC (20.times.20 cm, 2 mm thickness, 90:8:2 v/v/v hexanes/EtOAc/NEt.sub.3.times.2). Total yield--61 mg (30%) as a white solid: TLC R.sub.f=0.38 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt.sub.3); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.99 (br s, 1H), 7.35 (partially resolved td, 1H, J.sub.SnH=24.5 Hz), 7.25 (partially resolved d, 1H, J=1.8 Hz), 7.18 (dt, 1H, J=8.4 Hz, J.sub.SnH=12.6 Hz), 6.36 (s, 1H), 4.47 (d, 1H, J=16.2 Hz), 4.07 (d, 1H, J=16.2 Hz), 2.96 and 2.95 (2 overlapping q, 2H, J=7.2 Hz), 2.91 and 2.88 (2 overlapping t, 2H, J=7.2 Hz), 2.39 (s, 3H), 2.18 (s, 3H), 1.36 (m, 2H), 1.28 (sextet, 2H, J=7.2 Hz), 1.00 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz), 0.02 (t, 9H, J=27.0 Hz).

8-(Butylethylamino)-4-(2,4-dimethylphenyl)-6-methyl-3,4-dihydro-1H-pyrido[- 2,3-b]pyrazin-2-one (191)

[0198] {(2,4-Dimethylphenyl)-[4-(butylethylamino)-6-methyl-3-nitropyridin-- 2-yl]amino}acetic acid ethyl ester (63 mg, 1.42.times.10.sup.-4 mol), Fe.sup.0 (82 mg, 1.47 mmol, 10.4 equiv.), conc. HCl.sub.(aq) (0.20 mL, 2.4 mmol, 16.9 equiv.), EtOH (4 mL) and boiling chips were heated at reflux under Ar.sub.(g) for 15 h. The reaction mixture was cooled to rt, filtered through Celite, the Celite was rinsed with EtOH, and the solvent was removed from the filtrate to give a brown oil. To the residue was added CH.sub.2Cl.sub.2 (10 mL) and a suspension of EDTA.2Na.sup.+.2H.sub.2O (0.66 g, 1.77 mmol, 1.2 equiv.) Fe.sup.0) in H.sub.2O (10 mL). The mixture was stirred at rt for 30 min, cooled to 0.degree. C., and neutralized with conc. NH.sub.4OH.sub.(aq). The layers were separated, the aqueous layer was extracted with CH.sub.2Cl.sub.2 (5 mL.times.2), and the combined CH.sub.2Cl.sub.2 layers were dried over MgSO.sub.4. The solvent was removed to give a blue-green syrup that was purified on silica Sep-Pak Classics (3 in series): CH.sub.2Cl.sub.2 (4 mL), hexanes (3 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (2 mL.times.2), 90:8:2 (1 mL.times.12), 85:12:3 (1 mL.times.8). The desired fractions were combined and purified again on silica Sep-Pak Classics (3 in series): CH.sub.2Cl.sub.2 (2 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (1 mL.times.25), 90:8:2 (5 mL.times.2) to afford 31 mg (59%) of a colorless syrup that solidified after scrapping and drying under vacuum: TLC R.sub.f=0.34 (silica, 75:20:5 v/v/v hexanes/EtOAc/NEt.sub.3); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.93 (br s, 1H), 7.09 (m, 3H), 6.32 (s, 1H), 2.11 (2 overlapping br s, 2H), 2.99 (q, 2H, J=7.2 Hz), 2.91 (t, 2H, J=7.2 Hz), 2.35 (s, 3H), 2.20 (s, 3H), 2.08 (s, 3H), 1.40 (m, 2H), 1.30 (sextet, 2H, J=7.2 Hz), 1.02 (t, 3H, J=7.2 Hz), 0.90 (t, 3H, J=7.2 Hz).

3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX)

[0199] 4-(N-Butyl-N-ethylamino)-2-chloro-6-methyl-3-nitro-pyridine (2.26 g, 8.32 mmol) was dissolved in MeOH (150 mL) followed by addition of 5 nCl.sub.2.2H.sub.2O (11.63 g, 51.55 mmol, 6.2 equiv.) and then conc. HCl.sub.(aq) (11 mL, 0.13 mol, 15.6 equiv.). The reaction mixture was stirred at reflux under Ar.sub.(g) for 17 h, cooled, and the solvent was removed to give a faint yellow oil that was dissolved in CH.sub.2Cl.sub.2 (125 mL) and added to a suspension of EDTA.2Na.sup.+.2H.sub.2O (23.87 g, 64.13 mmol, 1.2 equiv. Sn) in H.sub.2O (125 mL). The mixture was stirred at rt for 5 min (white precipitate formed) and then cooled to 0.degree. C. (aqueous layer pH=0). The aqueous layer was neutralized to pH=6-7 with conc. NH.sub.4OH.sub.(aq), the mixture was filtered through Celite, and the layers were separated. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (25 mL.times.3), the combined CH.sub.2Cl.sub.2 layers were dried over MgSO.sub.4, and the solvent was removed to give a yellow oil (1.97 g) that was purified by flash column chromatography (45 g silica, 1% MeOH/CH.sub.2Cl.sub.2-700 mL) to afford a colorless oil (1.34 g, 67%): TLC R.sub.f=0.6 (silica, 5% MeOH/CH.sub.2Cl.sub.2); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 6.66 (br s, 1H), 4.00 (br s, 2H), 3.04 (q, 2H, J=7.2 Hz), 2.97 (t, 2H, J=7.5 Hz), 2.39 (s, 3H), 1.40 (quintet, 2H, J=7.5 Hz), 1.28 (sextet, 2H, J=7.5 Hz), 1.01 (t, 3H, J=7.2 Hz), 0.89 t, 3H, J=7.5 Hz); .sup.13C NMR (150 MHz, CDCl.sub.3) .delta. 147.14, 146.49, 136.44, 133.14, 115.50, 50.53, 45.70, 29.29, 23.64, 20.46, 14.07, 12.26; HRMS (ESI) [MH].sup.+ Calcd for C.sub.12H.sub.21N.sub.3.sup.35Cl: 242.1419. found: 242.1415.

4-(N-Butyl-N-ethylamino)-3-(2-chloroacetamido)-2-chloro-6-methyl-pyridine (XXX)

[0200] 3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX) (0.46 g, 1.90 mmol), chloroacetic anhydride (1.80 g, 10.53 mmol, 5.5 equiv.), iPr.sub.2NEt (0.51 mL, 2.9 mmol, 1.5 equiv.), and CHCl.sub.3 (50 mL) were stirred at reflux under Ar.sub.(g) for 17 h. The solvent was removed to give a yellow-brown oil that was dried under vacuum (2.67 g) and then purified by vacuum flash chromatography on silica (12.5 cm h.times.4 cm i.d.): CH.sub.2Cl.sub.2 (100 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 75:20:5 (500 mL), 50:45:5 (400 mL) to afford an off-white solid (0.54 g, 89%): TLC R.sub.f=0.35 (silica, 50:45:5 v/v/v hexanes/EtOAc/NEt.sub.3); .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.80 (s, 1H), 6.54 (s, 1H), 4.23 (s, 2H), 3.24 (q, 2H, J=7.2 Hz), 3.15 (t, 2H, J=7.2 Hz) 2.42 (s, 3H), 1.51 (m, 2H), 1.30 (sextet, 2H, J=7.5 Hz), 1.14 (t, 3H, J=7.2 Hz), 0.93 (t, 3H, J=7.5 Hz); .sup.13C NMR (150 MHz, CDCl.sub.3) .delta. 165.13, 157.36, 155.81, 150.86, 115.74, 111.69, 51.01, 46.50, 42.89, 30.03, 24.46, 20.44, 14.06, 13.15; HRMS (ESI) [MH].sup.+ Calcd for C.sub.14H.sub.22ON.sub.3.sup.35Cl.sub.2: 318.1134. found: 318.1131

[0201] Synthesis of Compounds XXXII and XXXIII Using Bromoacetic Anhydride.

[0202] 3-Amino-4-(N-butyl-N-ethylamino)-2-chloro-6-methyl-pyridine (XXIX) (0.53 g, 2.19 mmol), bromoacetic anhydride (3.53 g, 13.58 mmol, 6.2 equiv.), iPr.sub.2NEt (0.57 mL, 3.27 mmol, 1.5 equiv.), and CHCl.sub.3 were stirred at reflux under Ar.sub.(g) for 21 h. The solvent was removed to give a brown syrup that was vacuum flash chromatographed on silica (13 cm h.times.4 cm i.d.): CH.sub.2Cl.sub.2 (150 mL), hexanes (100 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 90:8:2 (100 mL), 75:20:5 (400 mL), 50:45:5 (300 mL) to give an off-white solid (0.50 g) that was further purified by radial chromatography (4 mm silica): hexanes (25 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 95:4:1 (100 mL), 90:8:2 (250 mL), 85:12:3 (100 mL), 80:16:4 (100 mL) to afford two white solids: compound XXXII (0.18 g, 32%) and compound XXXIII (27 mg, 5%). Compound XXXII. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.72 (br s, 1H), 6.32 (s, 1H), 4.01 (s, 2H), 3.26 (t, 2H, J=7.5 Hz), 2.40 (s, 3H), 1.61 (quintet, 2H, J=7.5 Hz) 1.41 (sextet, 2H, J=7.5 Hz), 1.00 (t, 3H, J=7.5 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.12H.sub.17ON.sub.3.sup.35Cl: 254.1055. found: 254.1051. Compound XXXIII. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.75 (br s, 1H), 6.35 (s, 1H), 3.99 (s, 2H), 3.36 (q, 2H, J=7.2 Hz), 2.40 (s, 3H), 1.23 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.10H.sub.13ON.sub.3.sup.35Cl: 226.0742. found: 226.0738.

4-(N-Butyl-N-ethylamino)-3-(2-(benzylamino)acetamido)-2-chloro-6-methyl-py- ridine (17223)

[0203] 4-(N-Butyl-N-ethylamino)-3-(2-chloroacetamido)-2-chloro-6-methyl-py- ridine (XXX) (0.12 g, 3.77.times.10.sup.-4 mol), benzylamine (0.25 mL, 2.29 mmol, 6.1 equiv.), iPr.sub.2NEt (0.10 mL, 5.74.times.10.sup.-4 mol, 1.5 equiv.) and CH.sub.3CN (10 mL) were stirred at reflux under Ar.sub.(g) for 21 h. The solvent was removed to give a residue that was dissolved in CH.sub.2Cl.sub.2, poured onto dry silica (43 mm h.times.43 mm i.d.), and eluted under vacuum: CH.sub.2Cl.sub.2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 75:20:5 (100 mL), 50:45:5 (200 mL) to afford 0.11 g (75%) of a colorless syrup: .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 8.72 (br s, 1H), 7.35 (m, 4H), 7.30 (m, 1H), 6.53 (s, 1H), 3.93 (s, 2H), 3.49 (s, 2H), 3.22 (q, 2H, J=7.2 Hz), 3.14 (t, 2H, J=7.5 Hz), 2.42 (s, 3H), 1.95 (br s, 1H), 1.50 (m, 2H), 1.28 (sextet, 2H, J=7.5 Hz), 1.11 (t, 3H, J=7.2 Hz), 0.91 (t, 3H, J=7.5 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.21H.sub.30ON.sub.4.sup.35Cl: 389.2103. found: 389.2099.

4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyra- zin-2-one (8374)

[0204] 4-(N-Butyl-N-ethylamino)-3-(2-(benzylamino)acetamido)-2-chloro-6-me- thyl-pyridine (XXX) (0.11 g, 2.83.times.10.sup.-4 mol), iPr.sub.2NEt (0.10 mL, 5.74.times.10.sup.-4 mol, 2 equiv), and nBuOH (40 mL) were stirred at reflux under Ar.sub.(g) for 64 h. The solvent was removed azeotropically with heptane to give a colorless syrup that was dissolved in CH.sub.2Cl.sub.2, poured onto dry silica (43 mm h.times.43 mm i.d.), and eluted under vacuum: CH.sub.2Cl.sub.2 (50 mL), hexanes (50 mL), hexanes/EtOAc/NEt.sub.3 v/v/v 90:8:2 (100 mL), 75:20:5 (100 mL), 50:45:5 (200 mL) to afford 80 mg (80%) of a colorless residue: .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.89 (br s, 1H), 7.37 (d, 2H, J=7.2 Hz), 7.33 (t, 2H, J=7.2 Hz), 7.28 (d, 1H, J=7.2 Hz), 6.33 (s, 1H), 4.82 (s, 2H), 3.88 (s, 2H), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.21H.sub.290N.sub.4: 353.2336. found: 353.2329; HPLC: t.sub.R=17.2 min (Waters XTerra+guard, 70:30:0.1 v/v/v MeOH/H.sub.2O/NEt.sub.3, 9.2 mL/min).

4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyra- zin-2-one HCl salt (8374.HCl)

[0205] 4-(N-Benzyl)-8-(butylethylamino)-6-methyl-3,4-dihydro-1H-pyrido[2,3- -b]pyrazin-2-one (8374) (71 mg, 2.01.times.10.sup.-4 mol) was dissolved in EtOEt (3 mL) and cooled to 0.degree. C. under Ar.sub.(g). HCl (2.0 M in EtOEt, 0.2 mL, 0.4 mmol, 2 equiv.) was added dropwise, the mixture was stirred for 5 min, filtered, and the white solid was dried under vacuum (71 mg, 91%). X-ray quality crystals were grown by dissolving 5.6 mg of the white solid in MeOH (1 mL) and then allowing the MeOH to slowly evaporate. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.81 (br s, 1H), 7.35 (m, 5H), 6.33 (s, 1H), 5.39 (s, 2H), 4.01 (s, 2H), 3.24 (q, 2H, J=7.2 Hz), 3.16 (t, 2H, J=7.5 Hz), 3.07 (s, 3H), 1.50 (m, 2H), 1.30 (sextet, 2H, J=7.5 Hz), 1.15 (t, 3H, J=7.2 Hz), 0.92 (t, 3H, J=7.2 Hz).

[0206] Compounds 8375 and 8376 were prepared in a similar manner as compound 8374, and compounds (R/S)-8404, (R)-8404, (S)-8404, and (S)-8409 were also prepared in the same manner except that cyclohexanol was used in place of nBuOH.

[0207] Compound 8375. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.88 (br s, 1H), 7.40 (m, 2H), 7.20 (dd, 1H, J=1.8 Hz, J=8.4 Hz), 6.34 (s, 1H), 4.89 (s, 2H), 3.97 (s, 2H), 2.94 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.34 (s, 3H), 1.37 (m, 2H), 1.28 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.21H.sub.27ON.sub.4.sup.35Cl.sub.2: 421.1556. found: 421.1552.

[0208] Compound 8376. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.87 (br s, 1H), 7.42 (d, 1H, J=8.4 Hz), 6.46 (m, 1H), 6.44 (d, 1H, J=2.4 Hz), 6.28 (s, 1H), 4.74 (s, 2H), 4.00 (s, 2H), 3.82 (s, 3H), 3.80 (s, 3H), 2.90 (q, 2H, J=7.2 Hz), 2.84 (t, 2H, J=7.2 Hz), 2.37 (s, 3H), 1.34 (m, 2H), 1.26 (sextet, 2H, J=7.2 Hz), 0.97 (t, 3H, J=7.2 Hz), 0.87 (t, 3H, J=7.2 Hz); HRMS (APCI) [MH].sup.+ Calcd for C.sub.23H.sub.33O.sub.3N.sub.4: 413.2547. found: 413.2540; HPLC: t.sub.R=3.5 min (XTerra+guard, 70:30:0.1 v/v/v MeOH/H.sub.2O/NEt.sub.3, 9.2 mL/min).

[0209] Compound (R/S)-8404. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.84 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t--partially obscured by CHCl.sub.3 solvent peak, 1H), 6.31 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.54 (d, 1H, J=16.2 Hz), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.22H.sub.31ON.sub.4: 367.2492. found: 367.2490.

[0210] Compound (R)-8404. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.85 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t, 1H, J=7.8 Hz), 6.32 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.55 (d, 1H, J=16.2 Hz), 2.93 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.22H.sub.31ON.sub.4: 367.2492. found: 367.2490.

[0211] Compound (S)-8404. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.84 (br s, 1H), 7.41 (d, 2H, J=7.8 Hz), 7.33 (t, 2H, J=7.8 Hz), 7.26 (t, 1H, J=7.8 Hz), 6.31 (overlapping s+q, 2H, J=7.2 Hz), 3.86 (d, 1H, J=16.2 Hz), 3.54 (d, 1H, J=16.2 Hz), 2.93 (q, 2H, J=7.2 Hz), 2.87 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.57 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz); HRMS (ESI) [MH].sup.+ Calcd for C.sub.22H.sub.31ON.sub.4: 367.2492. found: 367.2490.

[0212] Compound (S)-8409. .sup.1H NMR (600 MHz, CDCl.sub.3) .delta. 7.82 (br s, 1H), 7.34 (d, 2H, J=8.4 Hz), 6.86 (d, 2H, J=8.4 Hz), 6.31 (s, 1H), 6.25 (q, 1H, J=7.2 Hz), 3.83 (d, 1H, J=16.2 Hz), 3.80 (s, 3H), 3.53 (d, 1H, J=16.2 Hz), 2.92 (q, 2H, J=7.2 Hz), 2.86 (t, 2H, J=7.2 Hz), 2.38 (s, 3H), 1.54 (d, 3H, J=7.2 Hz), 1.37 (m, 2H), 1.27 (sextet, 2H, J=7.2 Hz), 0.99 (t, 3H, J=7.2 Hz), 0.88 (t, 3H, J=7.2 Hz).

TABLE-US-00016 TABLE 1 Substituent list for compounds of general structure VI. VI ##STR00087## Compound # R.sup.1 = R.sup.2 = R.sup.3 = 1 Bu Et H 2 Bu Et 2-t-Bu 3 Bu Et 2-Br 4 Bu Et 3-Br 5 Bu Et 4-Br 6 Bu Et 2-I 7 Bu Et 3-I 8 Bu Et 4-I 9 Bu Et 2-SnMe.sub.3 10 Bu Et 3-SnMe.sub.3 11 Bu Et 4-SnMe.sub.3 12 Bu Et 2-Me 13 Bu Et 3-Me 14 Bu Et 4-Me 15 Bu Et 2-OH 16 Bu Et 3-OH 17 Bu Et 4-OH 18 Bu Et 2-OMe 19 Bu Et 3-OMe 20 Bu Et 4-OMe 21 Bu Et 2-OMeF 22 Bu Et 3-OMeF 23 Bu Et 4-OMeF 24 Bu Et 2-OCF.sub.3 25 Bu Et 3-OCF.sub.3 26 Bu Et 4-OCF.sub.3 27 Bu Et 2-OEtF 28 Bu Et 3-OEtF 29 Bu Et 4-OEtF 30 Bu Et 2-OPrF 31 Bu Et 3-OPrF 32 Bu Et 4-OPrF 33 Bu Et 2-SH 34 Bu Et 3-SH 35 Bu Et 4-SH 36 Bu Et 2-SMe 37 Bu Et 3-SMe 38 Bu Et 4-SMe 39 Bu Et 2-SMeF 40 Bu Et 3-SMeF 41 Bu Et 4-SMeF 42 Bu Et 2-SCF.sub.3 43 Bu Et 3-SCF.sub.3 44 Bu Et 4-SCF.sub.3 45 Bu Et 2-SEtF 46 Bu Et 3-SEtF 47 Bu Et 4-SEtF 48 Bu Et 2-SPrF 49 Bu Et 3-SPrF 50 Bu Et 4-SPrF 51 Bu Et 2-OMe, 4-OMe 52 Bu Et 2-Me, 5-OH 53 Bu Et 2-Me, 5-OMe 54 Bu Et 2-Me, 5-OMeF 55 Bu Et 2-Me, 5-OEtF 56 Bu Et 2-Me, 5-OPrF 57 Bu Et 2-Me, 4-OH 58 Bu Et 2-Me, 4-OMeF 59 Bu Et 2-Me, 4-OCF.sub.3 60 Bu Et 2-Me, 4-OEtF 61 Bu Et 2-Me, 4-OPrF 62 Bu Et 2-OH, 4-Me 63 Bu Et 2-OMe, 4-Me 64 Bu Et 2-OMeF, 4-Me 65 Bu Et 2-OCF.sub.3, 4-Me 66 Bu Et 2-OEtF, 4-Me 67 Bu Et 2-OPrF, 4-Me 68 Bu Et 2-Cl, 4-OH 69 Bu Et 2-Cl, 4-OMeF 70 Bu Et 2-Cl, 4-OCF.sub.3 71 Bu Et 2-Cl, 4-OEtF 72 Bu Et 2-Cl, 4-OPrF 73 Bu Et 2-F, 4-F 74 Bu Et 2-Cl, 4-F 75 Bu Et 2-Cl, 4-NO.sub.2 76 Bu Et 2-Cl, 4-NH.sub.2 77 Bu Et 2-Cl, 4-NHMe 78 Bu Et 2-Cl, 4-NMe.sub.2 79 Bu Et 2-Cl, 4-NMe.sub.3OTf 80 Bu Et 2-Cl, 4-NMe.sub.3I 81 Bu Et 2-Cl, 5-F 82 Bu Et 2-Cl, 5-NO.sub.2 83 Bu Et 2-Cl, 5-NH.sub.2 84 Bu Et 2-Cl, 5-NHMe 85 Bu Et 2-Cl, 5-NMEe.sub.2 86 Bu Et 2-Cl, 5-NMe.sub.3OTf 87 Bu Et 2-Cl, 5-NMe.sub.3I 88 Bu Et 2-F, 4-Cl 89 Bu Et 2-NO.sub.2, 4-Cl 90 Bu Et 2-NH.sub.2, 4-Cl 91 Bu Et 2-NHMe, 4-Cl 92 Bu Et 2-NMe.sub.2, 4-Cl 93 Bu Et 2-NMe.sub.3OTf, 4-Cl 94 Bu Et 2-NMe.sub.3I, 4-Cl 95 Bu Et 2-F, 5-Cl 96 Bu Et 2-NO.sub.2, 5-Cl 97 Bu Et 2-NH.sub.2, 5-Cl 98 Bu Et 2-NHMe, 5-Cl 99 Bu Et 2-NMe.sub.2, 5-Cl 100 Bu Et 2-NMe.sub.3OTf, 5-Cl 101 Bu Et 2-NMe.sub.3I, 5-Cl 102 Bu Et 2-Br, 4-F 103 Bu Et 2-Br, 4-NO.sub.2 104 Bu Et 2-Br, 4-NH.sub.2 105 Bu Et 2-Br, 4-NHMe 106 Bu Et 2-Br, 4-NMe.sub.2 107 Bu Et 2-Br, 4- NMe.sub.3OTf 108 Bu Et 2-Br, 4-NMe.sub.3I 109 Bu Et 2-Br, 5-F 110 Bu Et 2-Br, 5-NO.sub.2 111 Bu Et 2-Br, 3-NH.sub.2 112 Bu Et 2-Br, 5-NHMe 113 Bu Et 2-Br, 5-NMe.sub.2 114 Bu Et 2-Br, 5- NMe.sub.3OTf 115 Bu Et 2-Br, 5-NMe.sub.3I 116 Bu Et 2-F, 4-Br 117 Bu Et 2-NO.sub.2, 4-Br 118 Bu Et 2-NH.sub.2, 4-Br 119 Bu Et 2-NHMe, 4-Br 120 Bu Et 2-NMe.sub.2, 4-Br 121 Bu Et 2-NMe.sub.3OTf, 4- Br 122 Bu Et 2-NMe.sub.3I, 4-Br 123 Bu Et 2-I, 4-F 124 Bu Et 2-I, 4-NO.sub.2 125 Bu Et 2-I, 4-NH.sub.2 126 Bu Et 2-I, 4-NHMe 127 Bu Et 2-I, 4-NMe.sub.2 128 Bu Et 2-I, 4-NMe.sub.3OTf 129 Bu Et 2-I, 4-NMe.sub.3I 130 Bu Et 2-F, 4-I 131 Bu Et 2-NO.sub.2, 4-I 132 Bu Et 2-NH.sub.2,4-I 133 Bu Et 2-NHMe, 4-I 134 Bu Et 2-NMe.sub.2, 4-I 135 Bu Et 2-NMe.sub.3OTf, 4-I 136 Bu Et 2-NMe.sub.3I, 4-I 137 Bu Et 2-Me, 3-F 138 Bu Et 2-Me, 3-NO.sub.2 139 Bu Et 2-Me, 3-NH.sub.2 140 Bu Et 2-Me, 3-NHMe 141 Bu Et 2-Me, 3-NMe.sub.2 142 Bu Et 2-Me, 3- NMe.sub.3OTf 143 Bu Et 2-Me, 3-NMe.sub.3I 144 Bu Et 2-Me, 4-F 145 Bu Et 2-Me, 4-NO.sub.2 146 Bu Et 2-Me, 4-NH.sub.2 147 Bu Et 2-Me, 4-NHMe 148 Bu Et 2-Me, 4-NMe.sub.2 149 Bu Et 2-Me, 4- NMe.sub.3OTf 150 Bu Et 2-Me, 4-NMe.sub.3I 151 Bu Et 2-Me, 5-F 152 Bu Et 2-Me, 5-NO.sub.2 153 Bu Et 2-Me, 5-NH.sub.2 154 Bu Et 2-Me, S-NHMe 155 Bu Et 2-Me, 5-NMe.sub.2 156 Bu Et 2-Me, 5- NMe.sub.3OTf 157 Bu Et 2-Me, 5-NMe.sub.3I 158 Bu Et 2-F, 4-Me 159 Bu Et 2-NO.sub.2, 4-Me 160 Bu Et 2-NH.sub.2, 4-Me 161 Bu Et 2-NHMe, 4-Me 162 Bu Et 2-NMe.sub.2, 4-Me 163 Bu Et 2-NMe.sub.3, 4-Me 164 Bu Et 2-NMe.sub.3OTf, 4- Me 165 Bu Et 2-NMe.sub.3I, 4-Me 166 Bu Et 2-SnMe.sub.3, 4-F 167 Bu Et 2-SnMe.sub.3, 5-F 168 Bu Et 2-F, 4-SnMe.sub.3 169 Bu Et 2-Br, 6-Cl, 4-F 170 Bu Et 2-Br, 6-Cl, 4- NO.sub.2 171 Bu Et 2-Br, 6-Cl, 4- NH.sub.2 172 Bu Et 2-Br, 6-Cl, 4- NHMe 173 Bu Et 2-Br, 6-Cl, 4- NMe.sub.2 174 Bu Et 2-Br, 6-Cl 4- NMe.sub.2OTf 175 Bu Et 2-Br, 6-Cl, 4- NMe.sub.3I 176 Bu Et 2-Me, 6-Cl, 4-F 177 Bu Et 2-SnMe.sub.3, 6-Cl, 4- F 178 Bu Et 2-Cl, 4-Me 179 Bu Et 2-Cl, 4-Br 180 Bu Et 2-Cl, 4-SnMe.sub.3 181 Bu Et 2-Br, 4-Cl 182 Bu Et 2-SnMe.sub.3, 4-Cl 183 Bu Et 2-Me, 4-Cl 184 Bu Et 2-Br, 4-Br 185 Bu Et 2-Br, 4-Me 186 Bu Et 2-Br, 4-SnMe.sub.3 187 Bu Et 2-SnMe.sub.3, 4-Br 188 Bu Et 2-Me, 4-Br 189 Bu Et 2-Me, 4-SnMe.sub.3 190 Bu Et 2-SnMe.sub.3, 4-Me 191 Bu Et 2-Me, 4-Me 192 Bu Et 2-Et, 4-Br 193 Bu Et 2-Et, 4-SnMe.sub.3, 194 Bu Et 2-Et, 4-Me 195 Bu Et 2-Me, 4-Br, 6-Me 196 Bu Et 2-Me, 4-SnMe.sub.3, 6-Me 197 Bu Et 2-Et, 6-Me 198 Bu Et 2-SnMe.sub.3,4-i-Pr 199 Bu Et 2-Me, 4-i-Pr 200 Bu Et 2-Br, 4-Br, 6-Br 201 Bu Et 2-Br, 4-Me, 6-Br 202 Bu Et 2-Br, 4-SnMe.sub.3, 6-Br 203 Bu Et 2-SnMe.sub.3, 4-Br, 6-Br 204 Bu Et 2-Br, 4-Br, 6-Me 205 Bu Et 2-Br, 4-CF.sub.3, 6-Br 206 Bu Et 2-Br, 4-Br, 6-CF.sub.3 207 Bu Et 2-CF.sub.3, 4-CF.sub.3 208 Bu Et 2-Cl, 4-CF.sub.3 209 Bu Et 2-CF.sub.3, 4-Cl 210 Bu Et 2-Br, 4-CF.sub.3 211 Bu Et 2-SnMe.sub.3, 4-CF.sub.3 212 Bu Et 2-Me, 4-CF.sub.3 213 Bu Et 2-CF.sub.3, 4-Br 214 Bu Et 2-CF.sub.3, 4-SnMe.sub.3 215 Bu Et 2-CF.sub.3, 4-Me 216 Bu Et 2-Br, 4-OH 217 Bu Et 2-Br, 4-OMe 218 Bu Et 2-Br, 4 OMeF 219 Bu Et 2-Br, 4-OCF.sub.3 220 Bu Et 2-Br, 4-OEtF 221 Bu Et 2-Br, 4-OPrF 222 Bu Et 2-OH, 4-Br 223 Bu Et 2-OMe, 4-Br 224 Bu Et 2-OMeF, 4-Br 225 Bu Et 2-OCF.sub.3, 4-Br

226 Bu Et 2-OEtF, 4-Br 227 Bu Et 2-OPrF, 4-Br 228 Bu Et 2-I, 4-OH 229 Bu Et 2-I, 4-OMe 230 Bu Et 2-I, 4-OMeF 231 Bu Et 2-I, 4-OCF.sub.3 232 Bu Et 2-I, 4-OEtF 233 Bu Et 2-I, 4-OPrF 234 Bu Et 2-OH, 4-I 235 Bu Et 2-OMe, 4-I 236 Bu Et 2-OMeF, 4-I 237 Bu Et 2-OCF.sub.3, 4-I 238 Bu Et 2-OEtF, 4-I 239 Bu Et 2-OPrF, 4-I 240 Bu Et 2-SnMe.sub.3, 4-OH 241 Bu Et 2-SnMe.sub.3, 4-OMe 242 Bu Et 2-SnMe.sub.3, 4- OMeF 243 Bu Et 2-SnMe.sub.3, 4-OCF.sub.3 244 Bu Et 2-SnMe.sub.3, 4-OEtF 245 Bu Et 2-SnMe.sub.3, 4-OPrF 246 Bu Et 2-OH, 4-SnMe.sub.3 247 Bu Et 2-OMe, 4-SnMe.sub.3 248 Bu Et 2-OMeF, 4- SnMe.sub.3 249 Bu Et 2-OCF.sub.3, 4-SnMe.sub.3 250 Bu Et 2-OEtF, 4-SnMe.sub.3 251 Bu Et 2-OPrF, 4-SnMe.sub.3 252 Pr Pr H 253 Pr Pr 2-t-Bu 254 Pr Pr 2-Br 255 Pr Pr 3-Br 256 Pr Pr 4-Br 257 Pr Pr 2-I 258 Pr Pr 3-I 259 Pr Pr 4-I 260 Pr Pr 2-SnMe.sub.3 261 Pr Pr 3-SnMe.sub.3 262 Pr Pr 4-SnMe.sub.3 263 Pr Pr 2-Me 264 Pr Pr 3-Me 265 Pr Pr 4-Me 266 Pr Pr 2-OH 267 Pr Pr 3-OH 268 Pr Pr 4-OH 269 Pr Pr 2-OMe 270 Pr Pr 3-OMe 271 Pr Pr 4-OMe 272 Pr Pr 2-OMeF 273 Pr Pr 3-OMeF 274 Pr Pr 4-OMeF 275 Pr Pr 2-OCF.sub.3 276 Pr Pr 3-OCF.sub.3 277 Pr Pr 4-OCF.sub.3 278 Pr Pr 2-OEtF 279 Pr Pr 3-OEtF 280 Pr Pr 4-OEtF 281 Pr Pr 2-OPrF 282 Pr Pr 3-OPrF 283 Pr Pr 4-OPrF 284 Pr Pr 2-SH 285 Pr Pr 3-SH 286 Pr Pr 4-SH 287 Pr Pr 2-SMe 288 Pr Pr 3-SMe 289 Pr Pr 4-SMe 290 Pr Pr 2-SMeF 291 Pr Pr 3-SMeF 292 Pr Pr 4-SMeF 293 Pr Pr 2-SCF.sub.3 294 Pr Pr 3-SCF.sub.3 295 Pr Pr 4-SCF.sub.3 296 Pr Pr 2-SEtF 297 Pr Pr 3-SEtF 298 Pr Pr 4-SEtF 299 Pr Pr 2-SPrF 300 Pr Pr 3-SPrF 301 Pr Pr 4-SPrF 302 Pr Pr 2-OMe, 4-OMe 303 Pr Pr 2-Me, 5-OH 304 Pr Pr 2-Me, 5-OMe 305 Pr Pr 2-Me, 5-OMeF 306 Pr Pr 2-Me, 5-OEtF 307 Pr Pr 2-Me, 5-OPrF 308 Pr Pr 2-Me, 4-OH 309 Pr Pr 2-Me, 4-OMe 310 Pr Pr 2-Me, 4-OMeF 311 Pr Pr 2-Me, 4-OCF.sub.3 312 Pr Pr 2-Me, 4-OEtF 313 Pr Pr 2-Me, 4-OPrF 314 Pr Pr 2-OH, 4-Me 315 Pr Pr 2-OMe, 4-Me 316 Pr Pr 2-OMeF, 4-Me 317 Pr Pr 2-OCF.sub.3, 4-Me 318 Pr Pr 2-OEtF, 4-Me 319 Pr Pr 2-OPrF, 4-Me 320 Pr Pr 2-Cl, 4-OH 321 Pr Pr 2-Cl, 4-OMe 322 Pr Pr 2-Cl, 4-OMeF 323 Pr Pr 2-Cl, 4-OCF.sub.3 324 Pr Pr 2-Cl, 4-OEtF 325 Pr Pr 2-Cl, 4-OPrF 326 Pr Pr 2-F, 4-F 327 Pr Pr 2-Cl, 4-Cl 328 Pr Pr 2-Cl, 4-F 329 Pr Pr 2-Cl, 4-NO.sub.2 330 Pr Pr 2-Cl, 4-NH.sub.2 331 Pr Pr 2-Cl, 4-NHMe 332 Pr Pr 2-Cl, 4-NMe.sub.2 333 Pr Pr 2-Cl, 4-NMe.sub.3OTf 334 Pr Pr 2-Cl, 4-NMe.sub.3I 335 Pr Pr 2-Cl, 5-F 336 Pr Pr 2-Cl, 5-NO.sub.2 337 Pr Pr 2-Cl, 5-NH.sub.2 338 Pr Pr 2-Cl, 5-NHMe 339 Pr Pr 2-Cl, 5-NMe.sub.2 340 Pr Pr 2-Cl, 5-NMe.sub.3OTf 341 Pr Pr 2-Cl, 5-NMe.sub.3I 342 Pr Pr 2-F, 4-Cl 343 Pr Pr 2-NO.sub.2, 4-Cl 344 Pr Pr 2-NH.sub.2, 4-Cl 345 Pr Pr 2-NHMe.sub.3, 4-Cl 346 Pr Pr 2-NMe.sub.2, 4-Cl 347 Pr Pr 2-NMe.sub.3OTf, 4-Cl 348 Pr Pr 2-NMe.sub.3I, 4-Cl 349 Pr Pr 2-F, 5-Cl 350 Pr Pr 2-NO.sub.2, 5-Cl 351 Pr Pr 2-NH.sub.2, 5-Cl 352 Pr Pr 2-NHMe, 5-Cl 353 Pr Pr 2-NMe.sub.2, 5-Cl 354 Pr Pr 2-NMe.sub.3OTf, 5-Cl 355 Pr Pr 2-NMe.sub.3I, 5-Cl 356 Pr Pr 2-Br, 4-F 357 Pr Pr 2-Br, 4-NO.sub.2 358 Pr Pr 2-Br, 4-NH.sub.2 359 Pr Pr 2-Br, 4-NHMe 360 Pr Pr 2-Br, 4-NMe.sub.2 361 Pr Pr 2-Br, 4- NMe.sub.3OTf 362 Pr Pr 2-Br, 4-NMe.sub.3I 363 Pr Pr 2-Br, 5-F 364 Pr Pr 2-Br, 5-NO.sub.2 365 Pr Pr 2-Br, 5-NH.sub.2 366 Pr Pr 2-Br, 5-NHMe 367 Pr Pr 2-Br, 5-NMe.sub.2 368 Pr Pr 2-Br, 5- NMe.sub.3OTf 369 Pr Pr 2-Br, 5-NMe.sub.3I 370 Pr Pr 2-F, 4-Br 371 Pr Pr 2-NO.sub.2, 4-Br 372 Pr Pr 2-NH.sub.2, 4-Br 373 Pr Pr 2-NHMe, 4-Br 374 Pr Pr 2-NMe.sub.2, 4-Br 375 Pr Pr 2-NMe.sub.3OTf, 4- Br 376 Pr Pr 2-NMe.sub.3I, 4-Br 377 Pr Pr 2-I, 4-F 378 Pr Pr 2-I, 4-NO.sub.2 379 Pr Pr 2-I, 4-NH.sub.2 380 Pr Pr 2-I, 4-NHMe 381 Pr Pr 2-I, 4-NMe.sub.2 382 Pr Pr 2-I, 4-NMe.sub.3OTf 383 Pr Pr 2-I, 4-NMe.sub.3I 384 Pr Pr 2-F, 4-I 385 Pr Pr 2-NO.sub.2, 4-I 386 Pr Pr 2-NH.sub.2,4-I 387 Pr Pr 2-NHMe, 4-I 388 Pr Pr 2-NMe.sub.2, 4-I 389 Pr Pr 2-NMe.sub.3OTf, 4-I 390 Pr Pr 2-NMe.sub.3I, 4-I 391 Pr Pr 2-Me, 3-F 392 Pr Pr 2-Me, 3-NO.sub.2 393 Pr Pr 2-Me, 3-NH.sub.2 394 Pr Pr 2-Me, 3-NHMe 395 Pr Pr 2-Me, 3-NMe.sub.2 396 Pr Pr 2-Me, 3- NMe.sub.3OTf 397 Pr Pr 2-Me, 3-NMe.sub.3I 398 Pr Pr 2-Me, 4-F 399 Pr Pr 2-Me, 4-NO.sub.2 400 Pr Pr 2-Me, 4-NH.sub.2 401 Pr Pr 2-Me, 4-NHMe 402 Pr Pr 2-Me, 4-NMe.sub.2 403 Pr Pr 2-Me, 4- NMe.sub.3OTf 404 Pr Pr 2-Me, 4-NMe.sub.3I 405 Pr Pr 2-Me, 5-F 406 Pr Pr 2-Me, 5-NO.sub.2 407 Pr Pr 2-Me, 5-NH.sub.2 408 Pr Pr 2-Me, 5-NHMe 409 Pr Pr 2-Me, 5-NMe.sub.2 410 Pr Pr 2-Me, 5- NMe.sub.3OTf 411 Pr Pr 2-Me, 5-NMe.sub.3I 412 Pr Pr 2-F, 4-Me 413 Pr Pr 2-NO.sub.2, 4-Me 414 Pr Pr 2-NH.sub.2, 4-Me 415 Pr Pr 2-NHMe, 4-Me 416 Pr Pr 2-NMe.sub.2, 4-Me 417 Pr Pr 2-NMe.sub.3, 4-Me 418 Pr Pr 2-NMe.sub.3OTf, 4- Me 419 Pr Pr 2-NMe.sub.3I, 4-Me 420 Pr Pr 2-SnMe.sub.3, 4-F 421 Pr Pr 2-SnMe.sub.3, 5-F 422 Pr Pr 2-F, 4-SnMe.sub.3 423 Pr Pr 2-Br, 6-Cl, 4-F 424 Pr Pr 2-Br, 6-Cl, 4- NO.sub.2 425 Pr Pr 2-Br, 6-Cl, 4- NH.sub.2 426 Pr Pr 2-Br, 6-Cl, 4- NHMe 427 Pr Pr 2-Br, 6-Cl, 4- NMe.sub.2 428 Pr Pr 2-Br, 6-Cl 4- NMe.sub.2OTf 429 Pr Pr 2-Br, 6-Cl, 4- NMe.sub.3I 430 Pr Pr 2-Me, 6-Cl, 4-F 431 Pr Pr 2-SnMe.sub.3, 6-Cl, 4- F 432 Pr Pr 2-Cl, 4-Me 433 Pr Pr 2-Cl, 4-Br 434 Pr Pr 2-Cl, 4-SnMe.sub.3 435 Pr Pr 2-Br, 4-Cl 436 Pr Pr 2-SnMe.sub.3, 4-Cl 437 Pr Pr 2-Me, 4-Cl 438 Pr Pr 2-Br, 4-Br 439 Pr Pr 2-Br, 4-Me 440 Pr Pr 2-Br, 4-SnMe.sub.3 441 Pr Pr 2-SnMe.sub.3, 4-Br 442 Pr Pr 2-Me, 4-Br 443 Pr Pr 2-Me, 4-SnMe.sub.3 444 Pr Pr 2-SnMe.sub.3, 4-Me 445 Pr Pr 2-Me, 4-Me 446 Pr Pr 2-Et, 4-Br 447 Pr Pr 2-Et, 4-SnMe.sub.3 448 Pr Pr 2-Et, 4-Me 449 Pr Pr 2-Me, 4-Me, 6-Me 450 Pr Pr 2-Me, 4-Br, 6-Me 451 Pr Pr 2-Me, 4-SnMe.sub.3, 6-Me 452 Pr Pr 2-Et, 6-Me 453 Pr Pr 2-Br, 4-i-Pr 454 Pr Pr 2-SnMe.sub.3,4-i-Pr 455 Pr Pr 2-Me, 4-i-Pr 456 Pr Pr 2-Br, 4-Br, 6-Br 457 Pr Pr 2-Br, 4-Me, 6-Br 458 Pr Pr 2-Br, 4-SnMe.sub.3, 6-Br

459 Pr Pr 2-SnMe.sub.3, 4-Br, 6-Br 460 Pr Pr 2-Br, 4-Br, 6-Me 461 Pr Pr 2-Br, 4-CF.sub.3, 6-Br 462 Pr Pr 2-Br, 4-Br, 6-CF.sub.3 463 Pr Pr 2-CF.sub.3, 4-CF.sub.3 464 Pr Pr 2-Cl, 4-CF.sub.3 465 Pr Pr 2-CF.sub.3, 4-Cl 466 Pr Pr 2-Br, 4-CF.sub.3 467 Pr Pr 2-SnMe.sub.3, 4-CF.sub.3 468 Pr Pr 2-Me, 4-CF.sub.3 469 Pr Pr 2-CF.sub.3, 4-Br 470 Pr Pr 2-CF.sub.3, 4-SnMe.sub.3 471 Pr Pr 2-CF.sub.3, 4-Me 472 Pr Pr 2-Br, 4-OH 473 Pr Pr 2-Br, 4-OMe 474 Pr Pr 2-Br, 4 OMeF 475 Pr Pr 2-Br, 4-OCF.sub.3 476 Pr Pr 2-Br, 4-OEtF 477 Pr Pr 2-Br, 4-OPrF 478 Pr Pr 2-OH, 4-Br 479 Pr Pr 2-OMe, 4-Br 480 Pr Pr 2-OMeF, 4-Br 481 Pr Pr 2-OCF.sub.3, 4-Br 482 Pr Pr 2-OEtF, 4-Br 483 Pr Pr 2-OPrF, 4-Br 484 Pr Pr 2-I, 4-OH 485 Pr Pr 2-I, 4-OMe 486 Pr Pr 2-I, 4-OMeF 487 Pr Pr 2-I, 4-OCF.sub.3 488 Pr Pr 2-I, 4-OEtF 489 Pr Pr 2-I, 4-OPrF 490 Pr Pr 2-OH, 4-I 491 Pr Pr 2-OMe, 4-I 492 Pr Pr 2-OMeF, 4-I 493 Pr Pr 2-OCF.sub.3, 4-I 494 Pr Pr 2-OEtF, 4-I 495 Pr Pr 2-OPrF, 4-I 496 Pr Pr 2-SnMe.sub.3, 4-OH 497 Pr Pr 2-SnMe.sub.3, 4-OMe 498 Pr Pr 2-SnMe.sub.3, 4- OMeF 499 Pr Pr 2-SnMe.sub.3, 4-OCF.sub.3 500 Pr Pr 2-SnMe.sub.3, 4-OEtF 501 Pr Pr 2-SnMe.sub.3, 4-OPrF 502 Pr Pr 2-OH, 4-SnMe.sub.3 503 Pr Pr 2-OMe, 4-SnMe.sub.3 504 Pr Pr 2-OMeF, 4- SnMe.sub.3 505 Pr Pr 2-OCF.sub.3, 4-SnMe.sub.3 506 Pr Pr 2-OEtF, 4-SnMe.sub.3 507 Pr Pr 2-OPrF, 4-SnMe.sub.3 508 Pr Pr--F H 509 Pr Pr--F 2-t-Bu 510 Pr Pr--F 2-Br 511 Pr Pr--F 3-Br 512 Pr Pr--F 4-Br 513 Pr Pr--F 2-I 514 Pr Pr--F 3-I 515 Pr Pr--F 4-I 516 Pr Pr--F 2-SnMe.sub.3 517 Pr Pr--F 3-SnMe.sub.3 518 Pr Pr--F 4-SnMe.sub.3 519 Pr Pr--F 2-Me 520 Pr Pr--F 3-Me 521 Pr Pr--F 4-Me 522 Pr Pr--F 2-OH 523 Pr Pr--F 3-OH 524 Pr Pr--F 4-OH 525 Pr Pr--F 2-OMe 526 Pr Pr--F 3-OMe 527 Pr Pr--F 4-OMe 528 Pr Pr--F 2-OMeF 529 Pr Pr--F 3-OMeF 530 Pr Pr--F 4-OMeF 531 Pr Pr--F 2-OCF.sub.3 532 Pr Pr--F 3-OCF.sub.3 533 Pr Pr--F 4-OCF.sub.3 534 Pr Pr--F 2-OEtF 535 Pr Pr--F 3-OEtF 536 Pr Pr--F 4-OEtF 537 Pr Pr--F 2-OPrF 538 Pr Pr--F 3-OPrF 539 Pr Pr--F 4-OPrF 540 Pr Pr--F 2-SH 541 Pr Pr--F 3-SH 542 Pr Pr--F 4-SH 543 Pr Pr--F 2-SMe 544 Pr Pr--F 3-SMe 545 Pr Pr--F 4-SMe 546 Pr Pr--F 2-SMeF 547 Pr Pr--F 3-SMeF 548 Pr Pr--F 4-SMeF 549 Pr Pr--F 2-SCF.sub.3 550 Pr Pr--F 3-SCF.sub.3 551 Pr Pr--F 4-SCF.sub.3 552 Pr Pr--F 2-SEtF 553 Pr Pr--F 3-SEtF 554 Pr Pr--F 4-SEtF 555 Pr Pr--F 2-SPrF 556 Pr Pr--F 3-SPrF 557 Pr Pr--F 4-SPrF 558 Pr Pr--F 2-OMe, 4-OMe 559 Pr Pr--F 2-Me, 5-OH 560 Pr Pr--F 2-Me, 5-OMe 561 Pr Pr--F 2-Me, 5-OMeF 562 Pr Pr--F 2-Me, 5-OEtF 563 Pr Pr--F 2-Me, 5-OPrF 564 Pr Pr--F 2-Me, 4-OH 565 Pr Pr--F 2-Me, 4-OMe 566 Pr Pr--F 2-Me, 4-OMeF 567 Pr Pr--F 2-Me, 4-OCF.sub.3 568 Pr Pr--F 2-Me, 4-OEtF 569 Pr Pr--F 2-Me, 4-OPrF 570 Pr Pr--F 2-OH, 4-Me 571 Pr Pr--F 2-OMe, 4-Me 572 Pr Pr--F 2-OMeF, 4-Me 573 Pr Pr--F 2-OCF.sub.3, 4-Me 574 Pr Pr--F 2-OEtF, 4-Me 575 Pr Pr--F 2-OPrF, 4-Me 576 Pr Pr--F 2-Cl, 4-OH 577 Pr Pr--F 2-Cl, 4-OMe 578 Pr Pr--F 2-Cl, 4-OMeF 579 Pr Pr--F 2-Cl, 4-OCF.sub.3 580 Pr Pr--F 2-Cl, 4-OEtF 581 Pr Pr--F 2-Cl, 4-OPrF 582 Pr Pr--F 2-F, 4-F 583 Pr Pr--F 2-Cl, 4-Cl 584 Pr Pr--F 2-Cl, 4-F 585 Pr Pr--F 2-Cl, 4-NO.sub.2 586 Pr Pr--F 2-Cl, 4-NH.sub.2 587 Pr Pr--F 2-Cl, 4-NHMe 588 Pr Pr--F 2-Cl, 4-NMe.sub.2 589 Pr Pr--F 2-Cl, 4-NMe.sub.3OTf 590 Pr Pr--F 2-Cl, 4-NMe.sub.3I 591 Pr Pr--F 2-Cl, 5-F 592 Pr Pr--F 2-Cl, 5-NO.sub.2 593 Pr Pr--F 2-Cl, 5-NH.sub.2 594 Pr Pr--F 2-Cl, 5-NHMe 595 Pr Pr--F 2-Cl, 5-NMe.sub.2 596 Pr Pr--F 2-Cl, 5-NMe.sub.3OTf 597 Pr Pr--F 2-Cl, 5-NMe.sub.3I 598 Pr Pr--F 2-F, 4-Cl 599 Pr Pr--F 2-NO.sub.2, 4-Cl 600 Pr Pr--F 2-NH.sub.2, 4-Cl 601 Pr Pr--F 2-NHMe.sub.3, 4-Cl 602 Pr Pr--F 2-NMe.sub.2, 4-Cl 603 Pr Pr--F 2-NMe.sub.3OTf, 4-Cl 604 Pr Pr--F 2-NMe.sub.3I, 4-Cl 605 Pr Pr--F 2-F, 5-Cl 606 Pr Pr--F 2-NO.sub.2, 5-Cl 607 Pr Pr--F 2-NH.sub.2, 5-Cl 608 Pr Pr--F 2-NHMe, 5-Cl 609 Pr Pr--F 2-NMe.sub.2, 5-Cl 610 Pr Pr--F 2-NMe.sub.3OTf, 5-Cl 611 Pr Pr--F 2-NMe.sub.3I, 5-Cl 612 Pr Pr--F 2-Br, 4-F 613 Pr Pr--F 2-Br, 4-NO.sub.2 614 Pr Pr--F 2-Br, 4-NH.sub.2 615 Pr Pr--F 2-Br, 4-NHMe 616 Pr Pr--F 2-Br, 4-NMe.sub.2 617 Pr Pr--F 2-Br, 4- NMe.sub.3OTf 618 Pr Pr--F 2-Br, 4-NMe.sub.3I 619 Pr Pr--F 2-Br, 5-F 620 Pr Pr--F 2-Br, 5-NO.sub.2 621 Pr Pr--F 2-Br, 5-NH.sub.2 622 Pr Pr--F 2-Br, 5-NHMe 623 Pr Pr--F 2-Br, 5-NMe.sub.2 624 Pr Pr--F 2-Br, 5- NMe.sub.3OTf 625 Pr Pr--F 2-Br, 5-NMe.sub.3I 626 Pr Pr--F 2-F, 4-Br 627 Pr Pr--F 2-NO.sub.2, 4-Br 628 Pr Pr--F 2-NH.sub.2, 4-Br 629 Pr Pr--F 2-NHMe, 4-Br 630 Pr Pr--F 2-NMe.sub.2, 4-Br 631 Pr Pr--F 2-NMe.sub.3OTf, 4- Br 632 Pr Pr--F 2-NMe.sub.3I, 4-Br 633 Pr Pr--F 2-I, 4-F 634 Pr Pr--F 2-I, 4-NO.sub.2 635 Pr Pr--F 2-I, 4-NH.sub.2 636 Pr Pr--F 2-I, 4-NHMe 637 Pr Pr--F 2-I, 4-NMe.sub.2 638 Pr Pr--F 2-I, 4-NMe.sub.3OTf 639 Pr Pr--F 2-I, 4-NMe.sub.3I 640 Pr Pr--F 2-F, 4-I 641 Pr Pr--F 2-NO.sub.2, 4-I 642 Pr Pr--F 2-NH.sub.2, 4-I 643 Pr Pr--F 2-NHMe, 4-I 644 Pr Pr--F 2-NMe.sub.2, 4-I 645 Pr Pr--F 2-NMe.sub.3OTf, 4-I 646 Pr Pr--F 2-NMe.sub.3I, 4-I 647 Pr Pr--F 2-Me, 3-F 648 Pr Pr--F 2-Me, 3-NO.sub.2 649 Pr Pr--F 2-Me, 3-NH.sub.2 650 Pr Pr--F 2-Me, 3-NHMe 651 Pr Pr--F 2-Me, 3-NMe.sub.2 652 Pr Pr--F 2-Me, 3- NMe.sub.3OTf 653 Pr Pr--F 2-Me, 3-NMe.sub.3I 654 Pr Pr--F 2-Me, 4-F 655 Pr Pr--F 2-Me, 4-NO.sub.2 656 Pr Pr--F 2-Me, 4-NH.sub.2 657 Pr Pr--F 2-Me, 4-NHMe 658 Pr Pr--F 2-Me, 4-NMe.sub.2 659 Pr Pr--F 2-Me, 4- NMe.sub.3OTf 660 Pr Pr--F 2-Me, 4-NMe.sub.3I 661 Pr Pr--F 2-Me, 5-F 662 Pr Pr--F 2-Me, 5-NO.sub.2 663 Pr Pr--F 2-Me, 5-NH.sub.2 664 Pr Pr--F 2-Me, 5-NHMe 665 Pr Pr--F 2-Me, 5-NMe.sub.2 666 Pr Pr--F 2-Me, 5- NMe.sub.3OTf 667 Pr Pr--F 2-Me, 5-NMe.sub.3I 668 Pr Pr--F 2-F, 4-Me 669 Pr Pr--F 2-NO.sub.2, 4-Me 670 Pr Pr--F 2-NH.sub.2, 4-Me 671 Pr Pr--F 2-NHMe, 4-Me 672 Pr Pr--F 2-NMe.sub.2, 4-Me 673 Pr Pr--F 2-NMe.sub.3, 4-Me 674 Pr Pr--F 2-NMe.sub.3OTf, 4- Me 675 Pr Pr--F 2-NMe.sub.3I, 4-Me 676 Pr Pr--F 2-SnMe.sub.3, 4-F 677 Pr Pr--F 2-SnMe.sub.3, 5-F 678 Pr Pr--F 2-F, 4-SnMe.sub.3 679 Pr Pr--F 2-Br, 6-Cl, 4-F 680 Pr Pr--F 2-Br, 6-Cl, 4- NO.sub.2 681 Pr Pr--F 2-Br, 6-Cl, 4- NH.sub.2 682 Pr Pr--F 2-Br, 6-Cl, 4- NHMe 683 Pr Pr--F 2-Br, 6-Cl, 4- NMe.sub.2 684 Pr Pr--F 2-Br, 6-Cl 4- NMe.sub.3OTf 685 Pr Pr--F 2-Br, 6-Cl, 4- NMe.sub.3I 686 Pr Pr--F 2-Me, 6-Cl, 4-F 687 Pr Pr--F 2-SnMe.sub.3, 6-Cl, 4- F 688 Pr Pr--F 2-Cl, 4-Me 689 Pr Pr--F 2-Cl, 4-Br 690 Pr Pr--F 2-Cl, 4-SnMe.sub.3 691 Pr Pr--F 2-Br, 4-Cl 692 Pr Pr--F 2-SnMe.sub.3, 4-Cl

693 Pr Pr--F 2-Me, 4-Cl 694 Pr Pr--F 2-Br, 4-Br 695 Pr Pr--F 2-Br, 4-Me 696 Pr Pr--F 2-Br, 4-SnMe.sub.3 697 Pr Pr--F 2-SnMe.sub.3, 4-Br 698 Pr Pr--F 2-Me, 4-Br 699 Pr Pr--F 2-Me, 4-SnMe.sub.3 700 Pr Pr--F 2-SnMe.sub.3, 4-Me 701 Pr Pr--F 2-Me, 4-Me 702 Pr Pr--F 2-Et, 4-Br 703 Pr Pr--F 2-Et, 4-SnMe.sub.3 704 Pr Pr--F 2-Et, 4-Me 705 Pr Pr--F 2-Me, 4-Me, 6-Me 706 Pr Pr--F 2-Me, 4-Br, 6-Me 707 Pr Pr--F 2-Me, 4-SnMe.sub.3, 6-Me 708 Pr Pr--F 2-Et, 6-Me 709 Pr Pr--F 2-Br, 4-i-Pr 710 Pr Pr--F 2-SnMe.sub.3, 4-i-Pr 711 Pr Pr--F 2-Me, 4-i-Pr 712 Pr Pr--F 2-Br, 4-Br, 6-Br 713 Pr Pr--F 2-Br, 4-Me, 6-Br 714 Pr Pr--F 2-Br, 4-SnMe.sub.3, 6-Br 715 Pr Pr--F 2-SnMe.sub.3, 4-Br, 6-Br 716 Pr Pr--F 2-Br, 4-Br, 6-Me 717 Pr Pr--F 2-Br, 4-CF.sub.3, 6-Br 718 Pr Pr--F 2-Br, 4-Br, 6-CF.sub.3 719 Pr Pr--F 2-CF.sub.3, 4-CF.sub.3 720 Pr Pr--F 2-Cl, 4-CF.sub.3 721 Pr Pr--F 2-CF.sub.3, 4-Cl 722 Pr Pr--F 2-Br, 4-CF.sub.3 723 Pr Pr--F 2-SnMe.sub.3, 4-CF.sub.3 724 Pr Pr--F 2-Me, 4-CF.sub.3 725 Pr Pr--F 2-CF.sub.3, 4-Br 726 Pr Pr--F 2-CF.sub.3, 4-SnMe.sub.3 727 Pr Pr--F 2-CF.sub.3, 4-Me 728 Pr Pr--F 2-Br, 4-OH 729 Pr Pr--F 2-Br, 4-OMe 730 Pr Pr--F 2-Br, 4 OMeF 731 Pr Pr--F 2-Br, 4-OCF.sub.3 732 Pr Pr--F 2-Br, 4-OEtF 733 Pr Pr--F 2-Br, 4-OPrF 734 Pr Pr--F 2-OH, 4-Br 735 Pr Pr--F 2-OMe, 4-Br 736 Pr Pr--F 2-OMeF, 4-Br 737 Pr Pr--F 2-OCF.sub.3, 4-Br 738 Pr Pr--F 2-OEtF, 4-Br 739 Pr Pr--F 2-OPrF, 4-Br 740 Pr Pr--F 2-I, 4-OH 741 Pr Pr--F 2-I, 4-OMe 742 Pr Pr--F 2-I, 4-OMeF 743 Pr Pr--F 2-I, 4-OCF.sub.3 744 Pr Pr--F 2-I, 4-OEtF 745 Pr Pr--F 2-I, 4-OPrF 746 Pr Pr--F 2-OH, 4-I 747 Pr Pr--F 2-OMe, 4-I 748 Pr Pr--F 2-OMeF, 4-I 749 Pr Pr--F 2-OCF.sub.3, 4-I 750 Pr Pr--F 2-OEtF, 4-I 751 Pr Pr--F 2-OPrF, 4-I 752 Pr Pr--F 2-SnMe.sub.3, 4-OH 753 Pr Pr--F 2-SnMe.sub.3, 4-OMe 754 Pr Pr--F 2-SnMe.sub.3, 4- OMeF 755 Pr Pr--F 2-SnMe.sub.3, 4-OCF.sub.3 756 Pr Pr--F 2-SnMe.sub.3, 4-OEtF 757 Pr Pr--F 2-SnMe.sub.3, 4-OPrF 758 Pr Pr--F 2-OH, 4-SnMe.sub.3 759 Pr Pr--F 2-OMe, 4-SnMe.sub.3 760 Pr Pr--F 2-OMeF, 4- SnMe.sub.3 761 Pr Pr--F 2-OCF.sub.3, 4-SnMe.sub.3 762 Pr Pr--F 2-OEtF, 4-SnMe.sub.3 763 Pr Pr--F 2-OPrF, 4-SnMe.sub.3 764 Pr Et--F H 765 Pr Et--F 2-t-Bu 766 Pr Et--F 2-Br 767 Pr Et--F 3-Br 768 Pr Et--F 4-Br 769 Pr Et--F 2-I 770 Pr Et--F 3-I 771 Pr Et--F 4-I 772 Pr Et--F 2-SnMe.sub.3 773 Pr Et--F 3-SnMe.sub.3 774 Pr Et--F 4-SnMe.sub.3 775 Pr Et--F 2-Me 776 Pr Et--F 3-Me 777 Pr Et--F 4-Me 778 Pr Et--F 2-OH 779 Pr Et--F 3-OH 780 Pr Et--F 4-OH 781 Pr Et--F 2-OMe 782 Pr Et--F 3-OMe 783 Pr Et--F 4-OMe 784 Pr Et--F 2-OMeF 785 Pr Et--F 3-OMeF 786 Pr Et--F 4-OMeF 787 Pr Et--F 2-OCF.sub.3 788 Pr Et--F 3-OCF.sub.3 789 Pr Et--F 4-OCF.sub.3 790 Pr Et--F 2-OEtF 791 Pr Et--F 3-OEtF 792 Pr Et--F 4-OEtF 793 Pr Et--F 2-OPrF 794 Pr Et--F 3-OPrF 795 Pr Et--F 4-OPrF 796 Pr Et--F 2-SH 797 Pr Et--F 3-SH 798 Pr Et--F 4-SH 799 Pr Et--F 2-SMe 800 Pr Et--F 3-SMe 801 Pr Et--F 4-SMe 802 Pr Et--F 2-SMeF 803 Pr Et--F 3-SMeF 804 Pr Et--F 4-SMeF 805 Pr Et--F 2-SCF.sub.3 806 Pr Et--F 3-SCF.sub.3 807 Pr Et--F 4-SCF.sub.3 808 Pr Et--F 2-SEtF 809 Pr Et--F 3-SEtF 810 Pr Et--F 4-SEtF 811 Pr Et--F 2-SPrF 812 Pr Et--F 3-SPrF 813 Pr Et--F 4-SPrF 814 Pr Et--F 2-OMe, 4-OMe 815 Pr Et--F 2-Me, 5-OH 816 Pr Et--F 2-Me, 5-OMe 817 Pr Et--F 2-Me, 5-OMeF 818 Pr Et--F 2-Me, 5-OEtF 819 Pr Et--F 2-Me, 5-OPrF 820 Pr Et--F 2-Me, 4-OH 821 Pr Et--F 2-Me, 4-OMe 822 Pr Et--F 2-Me, 4-OMeF 823 Pr Et--F 2-Me, 4-OCF.sub.3 824 Pr Et--F 2-Me, 4-OEtF 825 Pr Et--F 2-Me, 4-OPrF 826 Pr Et--F 2-OH, 4-Me 827 Pr Et--F 2-OMe, 4-Me 828 Pr Et--F 2-OMeF, 4-Me 829 Pr Et--F 2-OCF.sub.3, 4-Me 830 Pr Et--F 2-OEtF, 4-Me 831 Pr Et--F 2-OPrF, 4-Me 832 Pr Et--F 2-Cl, 4-OH 833 Pr Et--F 2-Cl, 4-OMe 834 Pr Et--F 2-Cl, 4-OMeF 835 Pr Et--F 2-Cl, 4-OCF.sub.3 836 Pr Et--F 2-Cl, 4-OEtF 837 Pr Et--F 2-Cl, 4-OPrF 838 Pr Et--F 2-F, 4-F 839 Pr Et--F 2-Cl, 4-Cl 840 Pr Et--F 2-Cl, 4-F 841 Pr Et--F 2-Cl, 4-NO.sub.2 842 Pr Et--F 2-Cl, 4-NH.sub.2 843 Pr Et--F 2-Cl, 4-NHMe 844 Pr Et--F 2-Cl, 4-NMe.sub.2 845 Pr Et--F 2-Cl, 4-NMe.sub.3OTf 846 Pr Et--F 2-Cl, 4-NMe.sub.3I 847 Pr Et--F 2-Cl, 5-F 848 Pr Et--F 2-Cl, 5-NO.sub.2 849 Pr Et--F 2-Cl, 5-NH.sub.2 850 Pr Et--F 2-Cl, 5-NHMe 851 Pr Et--F 2-Cl, 5-NMe.sub.2 852 Pr Et--F 2-Cl, 5-NMe.sub.3OTf 853 Pr Et--F 2-Cl, 5-NMe.sub.3I 854 Pr Et--F 2-F, 4-Cl 855 Pr Et--F 2-NO.sub.2, 4-Cl 856 Pr Et--F 2-NH.sub.2, 4-Cl 857 Pr Et--F 2-NHMe.sub.3, 4-Cl 858 Pr Et--F 2-NMe.sub.2, 4-Cl 859 Pr Et--F 2-NMe.sub.3OTf, 4-Cl 860 Pr Et--F 2-NMe.sub.3I, 4-Cl 861 Pr Et--F 2-F, 5-Cl 862 Pr Et--F 2-NO.sub.2, 5-Cl 863 Pr Et--F 2-NH.sub.2, 5-Cl 864 Pr Et--F 2-NHMe, 5-Cl 865 Pr Et--F 2-NMe.sub.2, 5-Cl 866 Pr Et--F 2-NMe.sub.3OTf, 5-Cl 867 Pr Et--F 2-NMe.sub.3I, 5-Cl 868 Pr Et--F 2-Br, 4-F 869 Pr Et--F 2-Br, 4-NO.sub.2 870 Pr Et--F 2-Br, 4-NH.sub.2 871 Pr Et--F 2-Br, 4-NHMe 872 Pr Et--F 2-Br, 4-NMe.sub.2 873 Pr Et--F 2-Br, 4- NMe.sub.3OTf 874 Pr Et--F 2-Br, 4-NMe.sub.3I 875 Pr Et--F 2-Br, 5-F 876 Pr Et--F 2-Br, 5-NO.sub.2 877 Pr Et--F 2-Br, 5-NH.sub.2 878 Pr Et--F 2-Br, 5-NHMe 879 Pr Et--F 2-Br, 5-NMe.sub.2 880 Pr Et--F 2-Br, 5- NMe.sub.3OTf 881 Pr Et--F 2-Br, 5-NMe.sub.3I 882 Pr Et--F 2-F, 4-Br 883 Pr Et--F 2-NO.sub.2, 4-Br 884 Pr Et--F 2-NH.sub.2, 4-Br 885 Pr Et--F 2-NHMe, 4-Br 886 Pr Et--F 2-NMe.sub.2, 4-Br 887 Pr Et--F 2-NMe.sub.3OTf, 4- Br 888 Pr Et--F 2-NMe.sub.3I, 4-Br 889 Pr Et--F 2-I, 4-F 890 Pr Et--F 2-I, 4-NO.sub.2 891 Pr Et--F 2-I, 4-NH.sub.2 892 Pr Et--F 2-I, 4-NHMe 893 Pr Et--F 2-I, 4-NMe.sub.2 894 Pr Et--F 2-I, 4-NMe.sub.3OTf 895 Pr Et--F 2-I, 4-NMe.sub.3I 896 Pr Et--F 2-F, 4-I 897 Pr Et--F 2-NO.sub.2, 4-I 898 Pr Et--F 2-NH.sub.2, 4-I 899 Pr Et--F 2-NHMe, 4-I 900 Pr Et--F 2-NMe.sub.2, 4-I 901 Pr Et--F 2-NMe.sub.3OTf, 4-I 902 Pr Et--F 2-NMe.sub.3I, 4-I 903 Pr Et--F 2-Me, 3-F 904 Pr Et--F 2-Me, 3-NO.sub.2 905 Pr Et--F 2-Me, 3-NH.sub.2 906 Pr Et--F 2-Me, 3-NHMe 907 Pr Et--F 2-Me, 3-NMe.sub.2 908 Pr Et--F 2-Me, 3- NMe.sub.3OTf 909 Pr Et--F 2-Me, 3-NMe.sub.3I 910 Pr Et--F 2-Me, 4-F 911 Pr Et--F 2-Me, 4-NO.sub.2 912 Pr Et--F 2-Me, 4-NH.sub.2 913 Pr Et--F 2-Me, 4-NHMe 914 Pr Et--F 2-Me, 4-NMe.sub.2 915 Pr Et--F 2-Me, 4- NMe.sub.3OTf 916 Pr Et--F 2-Me, 4-NMe.sub.3I 917 Pr Et--F 2-Me, 5-F 918 Pr Et--F 2-Me, 5-NO.sub.2 919 Pr Et--F 2-Me, 5-NH.sub.2 920 Pr Et--F 2-Me, 5-NHMe 921 Pr Et--F 2-Me, 5-NMe.sub.2 922 Pr Et--F 2-Me, 5- NMe.sub.3OTf 923 Pr Et--F 2-Me, 5-NMe.sub.3I 924 Pr Et--F 2-F, 4-Me 925 Pr Et--F 2-NO.sub.2, 4-Me 926 Pr Et--F 2-NH.sub.2, 4-Me 927 Pr Et--F 2-NHMe, 4-Me 928 Pr Et--F 2-NMe.sub.2, 4-Me 929 Pr Et--F 2-NMe.sub.3, 4-Me 930 Pr Et--F 2-NMe.sub.3OTf, 4- Me 931 Pr Et--F 2-NMe.sub.3I, 4-Me

932 Pr Et--F 2-SnMe.sub.3, 4-F 933 Pr Et--F 2-SnMe.sub.3, 5-F 934 Pr Et--F 2-F, 4-SnMe.sub.3 935 Pr Et--F 2-Br, 6-Cl, 4-F 936 Pr Et--F 2-Br, 6-Cl, 4- NO.sub.2 937 Pr Et--F 2-Br, 6-Cl, 4- NH.sub.2 938 Pr Et--F 2-Br, 6-Cl, 4- NHMe 939 Pr Et--F 2-Br, 6-Cl, 4- NMe.sub.2 940 Pr Et--F 2-Br, 6-Cl 4- NMe.sub.3OTf 941 Pr Et--F 2-Br, 6-Cl, 4- NMe.sub.3I 942 Pr Et--F 2-Me, 6-Cl, 4-F 943 Pr Et--F 2-SnMe.sub.3, 6-Cl, 4- F 944 Pr Et--F 2-Cl, 4-Me 945 Pr Et--F 2-Cl, 4-Br 946 Pr Et--F 2-Cl, 4-SnMe.sub.3 947 Pr Et--F 2-Br, 4-Cl 948 Pr Et--F 2-SnMe.sub.3, 4-Cl 949 Pr Et--F 2-Me, 4-Cl 950 Pr Et--F 2-Br, 4-Br 951 Pr Et--F 2-Br, 4-Me 952 Pr Et--F 2-Br, 4-SnMe.sub.3 953 Pr Et--F 2-SnMe.sub.3, 4-Br 954 Pr Et--F 2-Me, 4-Br 955 Pr Et--F 2-Me, 4-SnMe.sub.3 956 Pr Et--F 2-SnMe.sub.3, 4-Me 957 Pr Et--F 2-Me, 4-Me 958 Pr Et--F 2-Et, 4-Br 959 Pr Et--F 2-Et, 4-SnMe.sub.3 960 Pr Et--F 2-Et, 4-Me 961 Pr Et--F 2-Me, 4-Me, 6-Me 962 Pr Et--F 2-Me, 4-Br, 6-Me 963 Pr Et--F 2-Me, 4-SnMe.sub.3, 6-Me 964 Pr Et--F 2-Et, 6-Me 965 Pr Et--F 2-Br, 4-i-Pr 966 Pr Et--F 2-SnMe.sub.3, 4-i-Pr 967 Pr Et--F 2-Me, 4-i-Pr 968 Pr Et--F 2-Br, 4-Br, 6-Br 969 Pr Et--F 2-Br, 4-Me, 6-Br 970 Pr Et--F 2-Br, 4-SnMe.sub.3, 6-Br 971 Pr Et--F 2-SnMe.sub.3, 4-Br, 6-Br 972 Pr Et--F 2-Br, 4-Br, 6-Me 973 Pr Et--F 2-Br, 4-CF.sub.3, 6-Br 974 Pr Et--F 2-Br, 4-Br, 6-CF.sub.3 975 Pr Et--F 2-CF.sub.3, 4-CF.sub.3 976 Pr Et--F 2-Cl, 4-CF.sub.3 977 Pr Et--F 2-CF.sub.3, 4-Cl 978 Pr Et--F 2-Br, 4-CF.sub.3 979 Pr Et--F 2-SnMe.sub.3, 4-CF.sub.3 980 Pr Et--F 2-Me, 4-CF.sub.3 981 Pr Et--F 2-CF.sub.3, 4-Br 982 Pr Et--F 2-CF.sub.3, 4-SnMe.sub.3 983 Pr Et--F 2-CF.sub.3, 4-Me 984 Pr Et--F 2-Br, 4-OH 985 Pr Et--F 2-Br, 4-OMe 986 Pr Et--F 2-Br, 4-OMeF 987 Pr Et--F 2-Br, 4-OCF.sub.3 988 Pr Et--F 2-Br, 4-OEtF 989 Pr Et--F 2-Br, 4-OPrF 990 Pr Et--F 2-OH, 4-Br 991 Pr Et--F 2-OMe, 4-Br 992 Pr Et--F 2-OMeF, 4-Br 993 Pr Et--F 2-OCF.sub.3, 4-Br 994 Pr Et--F 2-OEtF, 4-Br 995 Pr Et--F 2-OPrF, 4-Br 996 Pr Et--F 2-I, 4-OH 997 Pr Et--F 2-I, 4-OMe 998 Pr Et--F 2-I, 4-OMeF 999 Pr Et--F 2-I, 4-OCF.sub.3 1000 Pr Et--F 2-I, 4-OEtF 1001 Pr Et--F 2-I, 4-OPrF 1002 Pr Et--F 2-OH, 4-I 1003 Pr Et--F 2-OMe, 4-I 1004 Pr Et--F 2-OMeF, 4-I 1005 Pr Et--F 2-OCF.sub.3, 4-I 1006 Pr Et--F 2-OEtF, 4-I 1007 Pr Et--F 2-OPrF, 4-I 1008 Pr Et--F 2-SnMe.sub.3, 4-OH 1009 Pr Et--F 2-SnMe.sub.3, 4-OMe 1010 Pr Et--F 2-SnMe.sub.3, 4- OMeF 1011 Pr Et--F 2-SnMe.sub.3, 4-OCF.sub.3 1012 Pr Et--F 2-SnMe.sub.3, 4-OEtF 1013 Pr Et--F 2-SnMe.sub.3, 4-OPrF 1014 Pr Et--F 2-OH, 4-SnMe.sub.3 1015 Pr Et--F 2-OMe, 4-SnMe.sub.3 1016 Pr Et--F 2-OMeF, 4- SnMe.sub.3 1017 Pr Et--F 2-OCF.sub.3, 4-SnMe.sub.3 1018 Pr Et--F 2-OEtF, 4-SnMe.sub.3 1019 Pr Et--F 2-OPrF, 4-SnMe.sub.3 1020 Pr--F Et H 1021 Pr--F Et 2-t-Bu 1022 Pr--F Et 2-Br 1023 Pr--F Et 3-Br 1024 Pr--F Et 4-Br 1025 Pr--F Et 2-I 1026 Pr--F Et 3-I 1027 Pr--F Et 4-I 1028 Pr--F Et 2-SnMe.sub.3 1029 Pr--F Et 3-SnMe.sub.3 1030 Pr--F Et 4-SnMe.sub.3 1031 Pr--F Et 2-Me 1032 Pr--F Et 3-Me 1033 Pr--F Et 4-Me 1034 Pr--F Et 2-OH 1035 Pr--F Et 3-OH 1036 Pr--F Et 4-OH 1037 Pr--F Et 2-OMe 1038 Pr--F Et 3-OMe 1039 Pr--F Et 4-OMe 1040 Pr--F Et 2-OMeF 1041 Pr--F Et 3-OMeF 1042 Pr--F Et 4-OMeF 1043 Pr--F Et 2-OCF.sub.3 1044 Pr--F Et 3-OCF.sub.3 1045 Pr--F Et 4-OCF.sub.3 1046 Pr--F Et 2-OEtF 1047 Pr--F Et 3-OEtF 1048 Pr--F Et 4-OEtF 1049 Pr--F Et 2-OPrF 1050 Pr--F Et 3-OPrF 1051 Pr--F Et 4-OPrF 1052 Pr--F Et 2-SH 1053 Pr--F Et 3-SH 1054 Pr--F Et 4-SH 1055 Pr--F Et 2-SMe 1056 Pr--F Et 3-SMe 1057 Pr--F Et 4-SMe 1058 Pr--F Et 2-SMeF 1059 Pr--F Et 3-SMeF 1060 Pr--F Et 4-SMeF 1061 Pr--F Et 2-SCF.sub.3 1062 Pr--F Et 3-SCF.sub.3 1063 Pr--F Et 4-SCF.sub.3 1064 Pr--F Et 2-SEtF 1065 Pr--F Et 3-SEtF 1066 Pr--F Et 4-SEtF 1067 Pr--F Et 2-SPrF 1068 Pr--F Et 3-SPrF 1069 Pr--F Et 4-SPrF 1070 Pr--F Et 2-OMe, 4-OMe 1071 Pr--F Et 2-Me, 5-OH 1072 Pr--F Et 2-Me, 5-OMe 1073 Pr--F Et 2-Me, 5-OMeF 1074 Pr--F Et 2-Me, 5-OEtF 1075 Pr--F Et 2-Me, 5-OPrF 1076 Pr--F Et 2-Me, 4-OH 1077 Pr--F Et 2-Me, 4-OMe 1078 Pr--F Et 2-Me, 4-OMeF 1079 Pr--F Et 2-Me, 4-OCF.sub.3 1080 Pr--F Et 2-Me, 4-OEtF 1081 Pr--F Et 2-Me, 4-OPrF 1082 Pr--F Et 2-OH, 4-Me 1083 Pr--F Et 2-OMe, 4-Me 1084 Pr--F Et 2-OMeF, 4-Me 1085 Pr--F Et 2-OCF.sub.3, 4-Me 1086 Pr--F Et 2-OEtF, 4-Me 1087 Pr--F Et 2-OPrF, 4-Me 1088 Pr--F Et 2-Cl, 4-OH 1089 Pr--F Et 2-Cl, 4-OMe 1090 Pr--F Et 2-Cl, 4-OMeF 1091 Pr--F Et 2-Cl, 4-OCF.sub.3 1092 Pr--F Et 2-Cl, 4-OEtF 1093 Pr--F Et 2-Cl, 4-OPrF 1094 Pr--F Et 2-F, 4-F 1095 Pr--F Et 2-Cl, 4-Cl 1096 Pr--F Et 2-Cl, 4-F 1097 Pr--F Et 2-Cl, 4-NO.sub.2 1098 Pr--F Et 2-Cl, 4-NH.sub.2 1099 Pr--F Et 2-Cl, 4-NHMe 1100 Pr--F Et 2-Cl, 4-NMe.sub.2 1101 Pr--F Et 2-Cl, 4-NMe.sub.3OTf 1102 Pr--F Et 2-Cl, 4-NMe.sub.3I 1103 Pr--F Et 2-Cl, 5-F 1104 Pr--F Et 2-Cl, 5-NO.sub.2 1105 Pr--F Et 2-Cl, 5-NH.sub.2 1106 Pr--F Et 2-Cl, 5-NHMe 1107 Pr--F Et 2-Cl, 5-NMe.sub.2 1108 Pr--F Et 2-Cl, 5-NMe.sub.3OTf 1109 Pr--F Et 2-Cl, 5-NMe.sub.3I 1110 Pr--F Et 2-F, 4-Cl 1111 Pr--F Et 2-NO.sub.2, 4-Cl 1112 Pr--F Et 2-NH.sub.2, 4-Cl 1113 Pr--F Et 2-NHMe.sub.3, 4-Cl 1114 Pr--F Et 2-NMe.sub.2, 4-Cl 1115 Pr--F Et 2-NMe.sub.3OTf, 4-Cl 1116 Pr--F Et 2-NMe.sub.3I, 4-Cl 1117 Pr--F Et 2-F, 5-Cl 1118 Pr--F Et 2-NO.sub.2, 5-Cl 1119 Pr--F Et 2-NH.sub.2, 5-Cl 1120 Pr--F Et 2-NHMe, 5-Cl 1121 Pr--F Et 2-NMe.sub.2, 5-Cl 1122 Pr--F Et 2-NMe.sub.3OTf, 5-Cl 1123 Pr--F Et 2-NMe.sub.3I, 5-Cl 1124 Pr--F Et 2-Br, 4-F 1125 Pr--F Et 2-Br, 4-NO.sub.2 1126 Pr--F Et 2-Br, 4-NH.sub.2 1127 Pr--F Et 2-Br, 4-NHMe 1128 Pr--F Et 2-Br, 4-NMe.sub.2 1129 Pr--F Et 2-Br, 4- NMe.sub.3OTf 1130 Pr--F Et 2-Br, 4-NMe.sub.3I 1131 Pr--F Et 2-Br, 5-F 1132 Pr--F Et 2-Br, 5-NO.sub.2 1133 Pr--F Et 2-Br, 5-NH.sub.2 1134 Pr--F Et 2-Br, 5-NHMe 1135 Pr--F Et 2-Br, 5-NMe.sub.2 1136 Pr--F Et 2-Br, 5- NMe.sub.3OTf 1137 Pr--F Et 2-Br, 5-NMe.sub.3I 1138 Pr--F Et 2-F, 4-Br 1139 Pr--F Et 2-NO.sub.2, 4-Br 1140 Pr--F Et 2-NH.sub.2, 4-Br 1141 Pr--F Et 2-NHMe, 4-Br 1142 Pr--F Et 2-NMe.sub.2, 4-Br 1143 Pr--F Et 2-NMe.sub.3OTf, 4- Br 1114 Pr--F Et 2-NMe.sub.3I, 4-Br 1115 Pr--F Et 2-I, 4-F 1116 Pr--F Et 2-I, 4-NO.sub.2 1117 Pr--F Et 2-I, 4-NH.sub.2 1148 Pr--F Et 2-I, 4-NHMe 1149 Pr--F Et 2-I, 4-NMe.sub.2 1150 Pr--F Et 2-I, 4-NMe.sub.3OTf 1151 Pr--F Et 2-I, 4-NMe.sub.3I 1152 Pr--F Et 2-F, 4-I 1153 Pr--F Et 2-NO.sub.2, 4-I 1154 Pr--F Et 2-NH.sub.2, 4-I 1155 Pr--F Et 2-NHMe, 4-I 1156 Pr--F Et 2-NMe.sub.2, 4-I 1157 Pr--F Et 2-NMe.sub.3OTf, 4-I 1158 Pr--F Et 2-NMe.sub.3I, 4-I 1159 Pr--F Et 2-Me, 3-F 1160 Pr--F Et 2-Me, 3-NO.sub.2 1161 Pr--F Et 2-Me, 3-NH.sub.2 1162 Pr--F Et 2-Me, 3-NHMe 1163 Pr--F Et 2-Me, 3-NMe.sub.2 1164 Pr--F Et 2-Me, 3- NMe.sub.3OTf 1165 Pr--F Et 2-Me, 3-NMe.sub.3I 1166 Pr--F Et 2-Me, 4-F

1167 Pr--F Et 2-Me, 4-NO.sub.2 1168 Pr--F Et 2-Me, 4-NH.sub.2 1169 Pr--F Et 2-Me, 4-NHMe 1170 Pr--F Et 2-Me, 4-NMe.sub.2 1171 Pr--F Et 2-Me, 4- NMe.sub.3OTf 1172 Pr--F Et 2-Me, 4-NMe.sub.3I 1173 Pr--F Et 2-Me, 5-F 1174 Pr--F Et 2-Me, 5-NO.sub.2 1175 Pr--F Et 2-Me, 5-NH.sub.2 1176 Pr--F Et 2-Me, 5-NHMe 1177 Pr--F Et 2-Me, 5-NMe.sub.2 1178 Pr--F Et 2-Me, 5- NMe.sub.3OTf 1179 Pr--F Et 2-Me, 5-NMe.sub.3I 1180 Pr--F Et 2-F, 4-Me 1181 Pr--F Et 2-NO.sub.2, 4-Me 1182 Pr--F Et 2-NH.sub.2, 4-Me 1183 Pr--F Et 2-NHMe, 4-Me 1184 Pr--F Et 2-NMe.sub.2, 4-Me 1185 Pr--F Et 2-NMe.sub.3, 4-Me 1186 Pr--F Et 2-NMe.sub.3OTf, 4- Me 1187 Pr--F Et 2-NMe.sub.3I, 4-Me 1188 Pr--F Et 2-SnMe.sub.3, 4-F 1189 Pr--F Et 2-SnMe.sub.3, 5-F 1190 Pr--F Et 2-F, 4-SnMe.sub.3 1191 Pr--F Et 2-Br, 6-Cl, 4-F 1192 Pr--F Et 2-Br, 6-Cl, 4- NO.sub.2 1193 Pr--F Et 2-Br, 6-Cl, 4- NH.sub.2 1194 Pr--F Et 2-Br, 6-Cl, 4- NHMe 1195 Pr--F Et 2-Br, 6-Cl, 4- NMe.sub.2 1196 Pr--F Et 2-Br, 6-Cl 4- NMe.sub.3OTf 1197 Pr--F Et 2-Br, 6-Cl, 4- NMe.sub.3I 1198 Pr--F Et 2-Me, 6-Cl, 4-F 1199 Pr--F Et 2-SnMe.sub.3, 6-Cl, 4- F 1200 Pr--F Et 2-Cl, 4-Me 1201 Pr--F Et 2-Cl, 4-Br 1202 Pr--F Et 2-Cl, 4-SnMe.sub.3 1203 Pr--F Et 2-Br, 4-Cl 1204 Pr--F Et 2-SnMe.sub.3, 4-Cl 1205 Pr--F Et 2-Me, 4-Cl 1206 Pr--F Et 2-Br, 4-Br 1207 Pr--F Et 2-Br, 4-Me 1208 Pr--F Et 2-Br, 4-SnMe.sub.3 1209 Pr--F Et 2-SnMe.sub.3, 4-Br 1210 Pr--F Et 2-Me, 4-Br 1211 Pr--F Et 2-Me, 4-SnMe.sub.3 1212 Pr--F Et 2-SnMe.sub.3, 4-Me 1213 Pr--F Et 2-Me, 4-Me 1214 Pr--F Et 2-Et, 4-Br 1215 Pr--F Et 2-Et, 4-SnMe.sub.3 1216 Pr--F Et 2-Et, 4-Me 1217 Pr--F Et 2-Me, 4-Me, 6-Me 1218 Pr--F Et 2-Me, 4-Br, 6-Me 1219 Pr--F Et 2-Me, 4-SnMe.sub.3, 6-Me 1220 Pr--F Et 2-Et, 6-Me 1221 Pr--F Et 2-Br, 4-i-Pr 1222 Pr--F Et 2-SnMe.sub.3, 4-i-Pr 1223 Pr--F Et 2-Me, 4-i-Pr 1224 Pr--F Et 2-Br, 4-Br, 6-Br 1225 Pr--F Et 2-Br, 4-Me, 6-Br 1226 Pr--F Et 2-Br, 4-SnMe.sub.3, 6-Br 1227 Pr--F Et 2-SnMe.sub.3, 4-Br, 6-Br 1228 Pr--F Et 2-Br, 4-Br, 6-Me 1229 Pr--F Et 2-Br, 4-CF.sub.3, 6-Br 1230 Pr--F Et 2-Br, 4-Br, 6-CF.sub.3 1231 Pr--F Et 2-CF.sub.3, 4-CF.sub.3 1232 Pr--F Et 2-Cl, 4-CF.sub.3 1233 Pr--F Et 2-CF.sub.3, 4-Cl 1234 Pr--F Et 2-Br, 4-CF.sub.3 1235 Pr--F Et 2-SnMe.sub.3, 4-CF.sub.3 1236 Pr--F Et 2-Me, 4-CF.sub.3 1237 Pr--F Et 2-CF.sub.3, 4-Br 1238 Pr--F Et 2-CF.sub.3, 4-SnMe.sub.3 1239 Pr--F Et 2-CF.sub.3, 4-Me 1240 Pr--F Et 2-Br, 4-OH 1241 Pr--F Et 2-Br, 4-OMe 1242 Pr--F Et 2-Br, 4-OMeF 1243 Pr--F Et 2-Br, 4-OCF.sub.3 1244 Pr--F Et 2-Br, 4-OEtF 1245 Pr--F Et 2-Br, 4-OPrF 1246 Pr--F Et 2-OH, 4-Br 1247 Pr--F Et 2-OMe, 4-Br 1248 Pr--F Et 2-OMeF, 4-Br 1249 Pr--F Et 2-OCF.sub.3, 4-Br 1250 Pr--F Et 2-OEtF, 4-Br 1251 Pr--F Et 2-OPrF, 4-Br 1252 Pr--F Et 2-I, 4-OH 1253 Pr--F Et 2-I, 4-OMe 1254 Pr--F Et 2-I, 4-OMeF 1255 Pr--F Et 2-I, 4-OCF.sub.3 1256 Pr--F Et 2-I, 4-OEtF 1257 Pr--F Et 2-I, 4-OPrF 1258 Pr--F Et 2-OH, 4-I 1259 Pr--F Et 2-OMe, 4-I 1260 Pr--F Et 2-OMeF, 4-I 1261 Pr--F Et 2-OCF.sub.3, 4-I 1262 Pr--F Et 2-OEtF, 4-I 1263 Pr--F Et 2-OPrF, 4-I 1264 Pr--F Et 2-SnMe.sub.3, 4-OH 1265 Pr--F Et 2-SnMe.sub.3, 4-OMe 1266 Pr--F Et 2-SnMe.sub.3, 4- OMeF 1267 Pr--F Et 2-SnMe.sub.3, 4-OCF.sub.3 1268 Pr--F Et 2-SnMe.sub.3, 4-OEtF 1269 Pr--F Et 2-SnMe.sub.3, 4-OPrF 1270 Pr--F Et 2-OH, 4-SnMe.sub.3 1271 Pr--F Et 2-OMe, 4-SnMe.sub.3 1272 Pr--F Et 2-OMeF, 4- SnMe.sub.3 1273 Pr--F Et 2-OCF.sub.3, 4-SnMe.sub.3 1274 Pr--F Et 2-OEtF, 4-SnMe.sub.3 1275 Pr--F Et 2-OPrF, 4-SnMe.sub.3 1276 Bu Et--F H 1277 Bu Et--F 2-t-Bu 1278 Bu Et--F 2-Br 1279 Bu Et--F 3-Br 1280 Bu Et--F 4-Br 1281 Bu Et--F 2-I 1282 Bu Et--F 3-I 1283 Bu Et--F 4-I 1284 Bu Et--F 2-SnMe.sub.3 1285 Bu Et--F 3-SnMe.sub.3 1286 Bu Et--F 4-SnMe.sub.3 1287 Bu Et--F 2-Me 1288 Bu Et--F 3-Me 1289 Bu Et--F 4-Me 1290 Bu Et--F 2-OH 1291 Bu Et--F 3-OH 1292 Bu Et--F 4-OH 1293 Bu Et--F 2-OMe 1294 Bu Et--F 3-OMe 1295 Bu Et--F 4-OMe 1296 Bu Et--F 2-OMeF 1297 Bu Et--F 3-OMeF 1298 Bu Et--F 4-OMeF 1299 Bu Et--F 2-OCF.sub.3 1300 Bu Et--F 3-OCF.sub.3 1301 Bu Et--F 4-OCF.sub.3 1302 Bu Et--F 2-OEtF 1303 Bu Et--F 3-OEtF 1304 Bu Et--F 4-OEtF 1305 Bu Et--F 2-OPrF 1306 Bu Et--F 3-OPrF 1307 Bu Et--F 4-OPrF 1308 Bu Et--F 2-SH 1309 Bu Et--F 3-SH 1310 Bu Et--F 4-SH 1311 Bu Et--F 2-SMe 1312 Bu Et--F 3-SMe 1313 Bu Et--F 4-SMe 1314 Bu Et--F 2-SMeF 1315 Bu Et--F 3-SMeF 1316 Bu Et--F 4-SMeF 1317 Bu Et--F 2-SCF.sub.3 1318 Bu Et--F 3-SCF.sub.3 1319 Bu Et--F 4-SCF.sub.3 1320 Bu Et--F 2-SEtF 1321 Bu Et--F 3-SEtF 1322 Bu Et--F 4-SEtF 1323 Bu Et--F 2-SPrF 1324 Bu Et--F 3-SPrF 1325 Bu Et--F 4-SPrF 1326 Bu Et--F 2-OMe, 4-OMe 1327 Bu Et--F 2-Me, 5-OH 1328 Bu Et--F 2-Me, 5-OMe 1329 Bu Et--F 2-Me, 5-OMeF 1330 Bu Et--F 2-Me, 5-OEtF 1331 Bu Et--F 2-Me, 5-OPrF 1332 Bu Et--F 2-Me, 4-OH 1333 Bu Et--F 2-Me, 4-OMe 1334 Bu Et--F 2-Me, 4-OMeF 1335 Bu Et--F 2-Me, 4-OCF.sub.3 1336 Bu Et--F 2-Me, 4-OEtF 1337 Bu Et--F 2-Me, 4-OPrF 1338 Bu Et--F 2-OH, 4-Me 1339 Bu Et--F 2-OMe, 4-Me 1340 Bu Et--F 2-OMeF, 4-Me 1341 Bu Et--F 2-OCF.sub.3, 4-Me 1342 Bu Et--F 2-OEtF, 4-Me 1343 Bu Et--F 2-OPrF, 4-Me 1344 Bu Et--F 2-Cl, 4-OH 1345 Bu Et--F 2-Cl, 4-OMe 1346 Bu Et--F 2-Cl, 4-OMeF 1347 Bu Et--F 2-Cl, 4-OCF.sub.3 1348 Bu Et--F 2-Cl, 4-OEtF 1349 Bu Et--F 2-Cl, 4-OPrF 1350 Bu Et--F 2-F, 4-F 1351 Bu Et--F 2-Cl, 4-Cl 1352 Bu Et--F 2-Cl, 4-F 1353 Bu Et--F 2-Cl, 4-NO.sub.2 1354 Bu Et--F 2-Cl, 4-NH.sub.2 1355 Bu Et--F 2-Cl, 4-NHMe 1356 Bu Et--F 2-Cl, 4-NMe.sub.2 1357 Bu Et--F 2-Cl, 4-NMe.sub.3OTf 1358 Bu Et--F 2-Cl, 4-NMe.sub.3I 1359 Bu Et--F 2-Cl, 5-F 1360 Bu Et--F 2-Cl, 5-NO.sub.2 1361 Bu Et--F 2-Cl, 5-NH.sub.2 1362 Bu Et--F 2-Cl, 5-NHMe 1363 Bu Et--F 2-Cl, 5-NMe.sub.2 1364 Bu Et--F 2-Cl, 5-NMe.sub.3OTf 1365 Bu Et--F 2-Cl, 5-NMe.sub.3I 1366 Bu Et--F 2-F, 4-Cl 1367 Bu Et--F 2-NO.sub.2, 4-Cl 1368 Bu Et--F 2-NH.sub.2, 4-Cl 1369 Bu Et--F 2-NHMe, 4-Cl 1370 Bu Et--F 2-NMe.sub.2, 4-Cl 1371 Bu Et--F 2-NMe.sub.3OTf, 4-Cl 1372 Bu Et--F 2-NMe.sub.3I, 4-Cl 1373 Bu Et--F 2-F, 5-Cl 1374 Bu Et--F 2-NO.sub.2, 5-Cl 1375 Bu Et--F 2-NH.sub.2, 5-Cl 1376 Bu Et--F 2-NHMe, 5-Cl 1377 Bu Et--F 2-NMe.sub.2, 5-Cl 1378 Bu Et--F 2-NMe.sub.3OTf, 5-Cl 1379 Bu Et--F 2-NMe.sub.3I, 5-Cl 1380 Bu Et--F 2-Br, 4-F 1381 Bu Et--F 2-Br, 4-NO.sub.2 1382 Bu Et--F 2-Br, 4-NH.sub.2 1383 Bu Et--F 2-Br, 4-NHMe 1384 Bu Et--F 2-Br, 4-NMe.sub.2 1385 Bu Et--F 2-Br, 4- NMe.sub.3OTf 1386 Bu Et--F 2-Br, 4-NMe.sub.3I 1387 Bu Et--F 2-Br, 5-F 1388 Bu Et--F 2-Br, 5-NO.sub.2 1389 Bu Et--F 2-Br, 5-NH.sub.2 1390 Bu Et--F 2-Br, 5-NHMe 1391 Bu Et--F 2-Br, 5-NMe.sub.2 1392 Bu Et--F 2-Br, 5- NMe.sub.3OTf 1393 Bu Et--F 2-Br, 5-NMe.sub.3I 1394 Bu Et--F 2-F, 4-Br 1395 Bu Et--F 2-NO.sub.2, 4-Br 1396 Bu Et--F 2-NH.sub.2, 4-Br 1397 Bu Et--F 2-NHMe, 4-Br 1398 Bu Et--F 2-NMe.sub.2, 4-Br 1399 Bu Et--F 2-NMe.sub.3OTf, 4- Br

1400 Bu Et--F 2-NMe.sub.3I, 4-Br 1401 Bu Et--F 2-I, 4-F 1402 Bu Et--F 2-I, 4-NO.sub.2 1403 Bu Et--F 2-I, 4-NH.sub.2 1404 Bu Et--F 2-I, 4-NHMe 1405 Bu Et--F 2-I, 4-NMe.sub.2 1406 Bu Et--F 2-I, 4-NMe.sub.3OTf 1407 Bu Et--F 2-I, 4-NMe.sub.3I 1408 Bu Et--F 2-F, 4-I 1409 Bu Et--F 2-NO.sub.2, 4-I 1410 Bu Et--F 2-NH.sub.2, 4-I 1411 Bu Et--F 2-NHMe, 4-I 1412 Bu Et--F 2-NMe.sub.2, 4-I 1413 Bu Et--F 2-NMe.sub.3OTf, 4-I 1414 Bu Et--F 2-NMe.sub.3I, 4-I 1415 Bu Et--F 2-Me, 3-F 1416 Bu Et--F 2-Me, 3-NO.sub.2 1417 Bu Et--F 2-Me, 3-NH.sub.2 1418 Bu Et--F 2-Me, 3-NHMe 1419 Bu Et--F 2-Me, 3-NMe.sub.2 1420 Bu Et--F 2-Me, 3- NMe.sub.3OTf 1421 Bu Et--F 2-Me, 3-NMe.sub.3I 1422 Bu Et--F 2-Me, 4-F 1423 Bu Et--F 2-Me, 4-NO.sub.2 1424 Bu Et--F 2-Me, 4-NH.sub.2 1425 Bu Et--F 2-Me, 4-NHMe 1426 Bu Et--F 2-Me, 4-NMe.sub.2 1427 Bu Et--F 2-Me, 4- NMe.sub.3OTf 1428 Bu Et--F 2-Me, 4-NMe.sub.3I 1429 Bu Et--F 2-Me, 5-F 1430 Bu Et--F 2-Me, 5-NO.sub.2 1431 Bu Et--F 2-Me, 5-NH.sub.2 1432 Bu Et--F 2-Me, 5-NHMe 1433 Bu Et--F 2-Me, 5-NMe.sub.2 1434 Bu Et--F 2-Me, 5- NMe.sub.3OTf 1435 Bu Et--F 2-Me, 5-NMe.sub.3I 1436 Bu Et--F 2-F, 4-Me 1437 Bu Et--F 2-NO.sub.2, 4-Me 1438 Bu Et--F 2-NH.sub.2, 4-Me 1439 Bu Et--F 2-NHMe, 4-Me 1440 Bu Et--F 2-NMe.sub.2, 4-Me 1441 Bu Et--F 2-NMe.sub.3, 4-Me 1442 Bu Et--F 2-NMe.sub.3OTf, 4- Me 1443 Bu Et--F 2-NMe.sub.3I, 4-Me 1444 Bu Et--F 2-SnMe.sub.3, 4-F 1445 Bu Et--F 2-SnMe.sub.3, 5-F 1446 Bu Et--F 2-F, 4-SnMe.sub.3 1447 Bu Et--F 2-Br, 6-Cl, 4-F 1448 Bu Et--F 2-Br, 6-Cl, 4- NO.sub.2 1449 Bu Et--F 2-Br, 6-Cl, 4- NH.sub.2 1450 Bu Et--F 2-Br, 6-Cl, 4- NHMe 1451 Bu Et--F 2-Br, 6-Cl, 4- NMe.sub.2 1452 Bu Et--F 2-Br, 6-Cl 4- NMe.sub.3OTf 1453 Bu Et--F 2-Br, 6-Cl, 4- NMe.sub.3I 1454 Bu Et--F 2-Me, 6-Cl, 4-F 1455 Bu Et--F 2-SnMe.sub.3, 6-Cl, 4- F 1456 Bu Et--F 2-Cl, 4-Me 1457 Bu Et--F 2-Cl, 4-Br 1458 Bu Et--F 2-Cl, 4-SnMe.sub.3 1459 Bu Et--F 2-Br, 4-Cl 1460 Bu Et--F 2-SnMe.sub.3, 4-Cl 1461 Bu Et--F 2-Me, 4-Cl 1462 Bu Et--F 2-Br, 4-Br 1463 Bu Et--F 2-Br, 4-Me 1464 Bu Et--F 2-Br, 4-SnMe.sub.3 1465 Bu Et--F 2-SnMe.sub.3, 4-Br 1466 Bu Et--F 2-Me, 4-Br 1467 Bu Et--F 2-Me, 4-SnMe.sub.3 1468 Bu Et--F 2-SnMe.sub.3, 4-Me 1469 Bu Et--F 2-Me, 4-Me 1470 Bu Et--F 2-Et, 4-Br 1471 Bu Et--F 2-Et, 4-SnMe.sub.3 1472 Bu Et--F 2-Et, 4-Me 1473 Bu Et--F 2-Me, 4-Me, 6-Me 1474 Bu Et--F 2-Me, 4-Br, 6-Me 1475 Bu Et--F 2-Me, 4-SnMe.sub.3, 6-Me 1476 Bu Et--F 2-Et, 6-Me 1477 Bu Et--F 2-Br, 4-i-Pr 1478 Bu Et--F 2-SnMe.sub.3, 4-i-Pr 1479 Bu Et--F 2-Me, 4-i-Pr 1480 Bu Et--F 2-Br, 4-Br, 6-Br 1481 Bu Et--F 2-Br, 4-Me, 6-Br 1482 Bu Et--F 2-Br, 4-SnMe.sub.3, 6-Br 1483 Bu Et--F 2-SnMe.sub.3, 4-Br, 6-Br 1484 Bu Et--F 2-Br, 4-Br, 6-Me 1485 Bu Et--F 2-Br, 4-CF.sub.3, 6-Br I486 Bu Et--F 2-Br, 4-Br, 6-CF.sub.3 1487 Bu Et--F 2-CF.sub.3, 4-CF.sub.3 1488 Bu Et--F 2-Cl, 4-CF.sub.3 1489 Bu Et--F 2-CF.sub.3, 4-Cl 1490 Bu Et--F 2-Br, 4-CF.sub.3 1491 Bu Et--F 2-SnMe.sub.3, 4-CF.sub.3 1492 Bu Et--F 2-Me, 4-CF.sub.3 1493 Bu Et--F 2-CF.sub.3, 4-Br 1494 Bu Et--F 2-CF.sub.3, 4-SnMe.sub.3 1495 Bu Et--F 2-CF.sub.3, 4-Me 1496 Bu Et--F 2-Br, 4-OH 1497 Bu Et--F 2-Br, 4-OMe 1498 Bu Et--F 2-Br, 4-OMeF 1499 Bu Et--F 2-Br, 4-OCF.sub.3 1500 Bu Et--F 2-Br, 4-OEtF 1501 Bu Et--F 2-Br, 4-OPrF 1502 Bu Et--F 2-OH, 4-Br 1503 Bu Et--F 2-OMe, 4-Br 1504 Bu Et--F 2-OMeF, 4-Br 1505 Bu Et--F 2-OCF.sub.3, 4-Br 1506 Bu Et--F 2-OEtF, 4-Br 1507 Bu Et--F 2-OPrF, 4-Br 1508 Bu Et--F 2-I, 4-OH 1509 Bu Et--F 2-I, 4-OMe 1510 Bu Et--F 2-I, 4-OMeF 1511 Bu Et--F 2-I, 4-OCF.sub.3 1512 Bu Et--F 2-I, 4-OEtF 1513 Bu Et--F 2-I, 4-OPrF 1514 Bu Et--F 2-OH, 4-I 1515 Bu Et--F 2-OMe, 4-I 1516 Bu Et--F 2-OMeF, 4-I 1517 Bu Et--F 2-OCF.sub.3, 4-I 1518 Bu Et--F 2-OEtF, 4-I 1519 Bu Et--F 2-OPrF, 4-I 1520 Bu Et--F 2-SnMe.sub.3, 4-OH 1521 Bu Et--F 2-SnMe.sub.3, 4-OMe 1522 Bu Et--F 2-SnMe.sub.3, 4- OMeF 1523 Bu Et--F 2-SnMe.sub.3, 4-OCF.sub.3 1524 Bu Et--F 2-SnMe.sub.3, 4-OEtF 1525 Bu Et--F 2-SnMe.sub.3, 4-OPrF 1526 Bu Et--F 2-OH, 4-SnMe.sub.3 1527 Bu Et--F 2-OMe, 4-SnMe.sub.3 1528 Bu Et--F 2-OMeF, 4- SnMe.sub.3 1529 Bu Et--F 2-OCF.sub.3, 4-SnMe.sub.3 1530 Bu Et--F 2-OEtF, 4-SnMe.sub.3 1531 Bu Et--F 2-OPrF, 4-SnMe.sub.3 1532 Bu--F Et H 1533 Bu--F Et 2-t-Bu 1534 Bu--F Et 2-Br 1535 Bu--F Et 3-Br 1536 Bu--F Et 4-Br 1537 Bu--F Et 2-I 1538 Bu--F Et 3-I 1539 Bu--F Et 4-I 1540 Bu--F Et 2-SnMe.sub.3 1541 Bu--F Et 3-SnMe.sub.3 1542 Bu--F Et 4-SnMe.sub.3 1543 Bu--F Et 2-Me 1544 Bu--F Et 3-Me 1545 Bu--F Et 4-Me 1546 Bu--F Et 2-OH 1547 Bu--F Et 3-OH 1548 Bu--F Et 4-OH 1549 Bu--F Et 2-OMe 1550 Bu--F Et 3-OMe 1551 Bu--F Et 4-OMe 1552 Bu--F Et 2-OMeF 1553 Bu--F Et 3-OMeF 1554 Bu--F Et 4-OMeF 1555 Bu--F Et 2-OCF.sub.3 1556 Bu--F Et 3-OCF.sub.3 1557 Bu--F Et 4-OCF.sub.3 1558 Bu--F Et 2-OEtF 1559 Bu--F Et 3-OEtF 1560 Bu--F Et 4-OEtF 1561 Bu--F Et 2-OPrF 1562 Bu--F Et 3-OPrF 1563 Bu--F Et 4-OPrF 1564 Bu--F Et 2-SH 1565 Bu--F Et 3-SH 1566 Bu--F Et 4-SH 1567 Bu--F Et 2-SMe 1568 Bu--F Et 3-SMe 1569 Bu--F Et 4-SMe 1570 Bu--F Et 2-SMeF 1571 Bu--F Et 3-SMeF 1572 Bu--F Et 4-SMeF 1573 Bu--F Et 2-SCF.sub.3 1574 Bu--F Et 3-SCF.sub.3 1575 Bu--F Et 4-SCF.sub.3 1576 Bu--F Et 2-SEtF 1577 Bu--F Et 3-SEtF 1578 Bu--F Et 4-SEtF 1579 Bu--F Et 2-SPrF 1580 Bu--F Et 3-SPrF 1581 Bu--F Et 4-SPrF 1582 Bu--F Et 2-OMe, 4-OMe 1583 Bu--F Et 2-Me, 5-OH 1584 Bu--F Et 2-Me, 5-OMe 1585 Bu--F Et 2-Me, 5-OMeF 1586 Bu--F Et 2-Me, 5-OEtF 1587 Bu--F Et 2-Me, 5-OPrF 1588 Bu--F Et 2-Me, 4-OH 1589 Bu--F Et 2-Me, 4-OMe 1590 Bu--F Et 2-Me, 4-OMeF 1591 Bu--F Et 2-Me, 4-OCF.sub.3 1592 Bu--F Et 2-Me, 4-OEtF 1593 Bu--F Et 2-Me, 4-OPrF 1594 Bu--F Et 2-OH, 4-Me 1595 Bu--F Et 2-OMe, 4-Me 1596 Bu--F Et 2-OMeF, 4-Me 1597 Bu--F Et 2-OCF.sub.3, 4-Me 1598 Bu--F Et 2-OEtF, 4-Me 1599 Bu--F Et 2-OPrF, 4-Me 1600 Bu--F Et 2-Cl, 4-OH 1601 Bu--F Et 2-Cl, 4-OMe 1602 Bu--F Et 2-Cl, 4-OMeF 1603 Bu--F Et 2-Cl, 4-OCF.sub.3 1604 Bu--F Et 2-Cl, 4-OEtF 1605 Bu--F Et 2-Cl, 4-OPrF 1606 Bu--F Et 2-F, 4-F 1607 Bu--F Et 2-Cl, 4-Cl 1608 Bu--F Et 2-Cl, 4-F 1609 Bu--F Et 2-Cl, 4-NO.sub.2 1610 Bu--F Et 2-Cl, 4-NH.sub.2 1611 Bu--F Et 2-Cl, 4-NHMe 1612 Bu--F Et 2-Cl, 4-NMe.sub.2 1613 Bu--F Et 2-Cl, 4-NMe.sub.3OTf 1614 Bu--F Et 2-Cl, 4-NMe.sub.3I 1615 Bu--F Et 2-Cl, 5-F 1616 Bu--F Et 2-Cl, 5-NO.sub.2 1617 Bu--F Et 2-Cl, 5-NH.sub.2 1618 Bu--F Et 2-Cl, 5-NHMe 1619 Bu--F Et 2-Cl, 5-NMe.sub.2 1620 Bu--F Et 2-Cl, 5-NMe.sub.3OTf 1621 Bu--F Et 2-Cl, 5-NMe.sub.3I 1622 Bu--F Et 2-F, 4-Cl 1623 Bu--F Et 2-NO.sub.2, 4-Cl 1624 Bu--F Et 2-NH.sub.2, 4-Cl 1625 Bu--F Et 2-NHMe, 4-Cl 1626 Bu--F Et 2-NMe.sub.2, 4-Cl 1627 Bu--F Et 2-NMe.sub.3OTf, 4-Cl 1628 Bu--F Et 2-NMe.sub.3I, 4-Cl 1629 Bu--F Et 2-F, 5-Cl 1630 Bu--F Et 2-NO.sub.2, 5-Cl 1631 Bu--F Et 2-NH.sub.2, 5-Cl 1632 Bu--F Et 2-NHMe, 5-Cl 1633 Bu--F Et 2-NMe.sub.2, 5-Cl 1634 Bu--F Et 2-NMe.sub.3OTf, 5-Cl

1635 Bu--F Et 2-NMe.sub.3I, 5-Cl 1636 Bu--F Et 2-Br, 4-F 1637 Bu--F Et 2-Br, 4-NO.sub.2 1638 Bu--F Et 2-Br, 4-NH.sub.2 1639 Bu--F Et 2-Br, 4-NHMe 1640 Bu--F Et 2-Br, 4-NMe.sub.2 1641 Bu--F Et 2-Br, 4- NMe.sub.3OTf 1642 Bu--F Et 2-Br, 4-NMe.sub.3I 1643 Bu--F Et 2-Br, 5-F 1644 Bu--F Et 2-Br, 5-NO.sub.2 1645 Bu--F Et 2-Br, 5-NH.sub.2 1646 Bu--F Et 2-Br, 5-NHMe 1647 Bu--F Et 2-Br, 5-NMe.sub.2 1648 Bu--F Et 2-Br, 5- NMe.sub.3OTf 1649 Bu--F Et 2-Br, 5-NMe.sub.3I 1650 Bu--F Et 2-F, 4-Br 1651 Bu--F Et 2-NO.sub.2, 4-Br 1652 Bu--F Et 2-NH.sub.2, 4-Br 1653 Bu--F Et 2-NHMe, 4-Br 1654 Bu--F Et 2-NMe.sub.2, 4-Br 1655 Bu--F Et 2-NMe.sub.3OTf, 4- Br 1656 Bu--F Et 2-NMe.sub.3I, 4-Br 1657 Bu--F Et 2-I, 4-F 1658 Bu--F Et 2-I, 4-NO.sub.2 1659 Bu--F Et 2-I, 4-NH.sub.2 1660 Bu--F Et 2-I, 4-NHMe 1661 Bu--F Et 2-I, 4-NMe.sub.2 1662 Bu--F Et 2-I, 4-NMe.sub.3OTf 1663 Bu--F Et 2-I, 4-NMe.sub.3I 1664 Bu--F Et 2-F, 4-I 1665 Bu--F Et 2-NO.sub.2, 4-I 1666 Bu--F Et 2-NH.sub.2, 4-I 1667 Bu--F Et 2-NHMe, 4-I 1668 Bu--F Et 2-NMe.sub.2, 4-I 1669 Bu--F Et 2-NMe.sub.3OTf, 4-I 1670 Bu--F Et 2-NMe.sub.3I, 4-I 1671 Bu--F Et 2-Me, 3-F 1672 Bu--F Et 2-Me, 3-NO.sub.2 1673 Bu--F Et 2-Me, 3-NH.sub.2 1674 Bu--F Et 2-Me, 3-NHMe 1675 Bu--F Et 2-Me, 3-NMe.sub.2 1676 Bu--F Et 2-Me, 3- NMe.sub.3OTf 1677 Bu--F Et 2-Me, 3-NMe.sub.3I 1678 Bu--F Et 2-Me, 4-F 1679 Bu--F Et 2-Me, 4-NO.sub.2 1680 Bu--F Et 2-Me, 4-NH.sub.2 1681 Bu--F Et 2-Me, 4-NHMe 1682 Bu--F Et 2-Me, 4-NMe.sub.2 1683 Bu--F Et 2-Me, 4- NMe.sub.3OTf 1684 Bu--F Et 2-Me, 4-NMe.sub.3I 1685 Bu--F Et 2-Me, 5-F 1686 Bu--F Et 2-Me, 5-NO.sub.2 1687 Bu--F Et 2-Me, 5-NH.sub.2 1688 Bu--F Et 2-Me, 5-NHMe 1689 Bu--F Et 2-Me, 5-NMe.sub.2 1690 Bu--F Et 2-Me, 5- NMe.sub.3OTf 1691 Bu--F Et 2-Me, 5-NMe.sub.3I 1692 Bu--F Et 2-F, 4-Me 1693 Bu--F Et 2-NO.sub.2, 4-Me 1694 Bu--F Et 2-NH.sub.2, 4-Me 1695 Bu--F Et 2-NHMe, 4-Me 1696 Bu--F Et 2-NMe.sub.2, 4-Me 1697 Bu--F Et 2-NMe.sub.3, 4-Me 1698 Bu--F Et 2-NMe.sub.3OTf, 4- Me 1699 Bu--F Et 2-NMe.sub.3I, 4-Me 1700 Bu--F Et 2-SnMe.sub.3, 4-F 1701 Bu--F Et 2-SnMe.sub.3, 5-F 1702 Bu--F Et 2-F, 4-SnMe.sub.3 1703 Bu--F Et 2-Br, 6-Cl, 4-F 1704 Bu--F Et 2-Br, 6-Cl, 4- NO.sub.2 1705 Bu--F Et 2-Br, 6-Cl, 4- NH.sub.2 1706 Bu--F Et 2-Br, 6-Cl, 4- NHMe 1707 Bu--F Et 2-Br, 6-Cl, 4- NMe.sub.2 1708 Bu--F Et 2-Br, 6-Cl 4- NMe.sub.3OTf 1709 Bu--F Et 2-Br, 6-Cl, 4- NMe.sub.3I 1710 Bu--F Et 2-Me, 6-Cl, 4-F 1711 Bu--F Et 2-SnMe.sub.3, 6-Cl, 4- F 1712 Bu--F Et 2-Cl, 4-Me 1713 Bu--F Et 2-Cl, 4-Br 1714 Bu--F Et 2-Cl, 4-SnMe.sub.3 1715 Bu--F Et 2-Br, 4-Cl 1716 Bu--F Et 2-SnMe.sub.3, 4-Cl 1717 Bu--F Et 2-Me, 4-Cl 1718 Bu--F Et 2-Br, 4-Br 1719 Bu--F Et 2-Br, 4-Me 1720 Bu--F Et 2-Br, 4-SnMe.sub.3 1721 Bu--F Et 2-SnMe.sub.3, 4-Br 1722 Bu--F Et 2-Me, 4-Br 1723 Bu--F Et 2-Me, 4-SnMe.sub.3 1724 Bu--F Et 2-SnMe.sub.3, 4-Me 1725 Bu--F Et 2-Me, 4-Me 1726 Bu--F Et 2-Et, 4-Br 1727 Bu--F Et 2-Et, 4-SnMe.sub.3 1728 Bu--F Et 2-Et, 4-Me 1729 Bu--F Et 2-Me, 4-Me, 6-Me 1730 Bu--F Et 2-Me, 4-Br, 6-Me 1731 Bu--F Et 2-Me, 4-SnMe.sub.3, 6-Me 1732 Bu--F Et 2-Et, 6-Me 1733 Bu--F Et 2-Br, 4-i-Pr 1734 Bu--F Et 2-SnMe.sub.3, 4-i-Pr 1735 Bu--F Et 2-Me, 4-i-Pr 1736 Bu--F Et 2-Br, 4-Br, 6-Br 1737 Bu--F Et 2-Br, 4-Me, 6-Br 1738 Bu--F Et 2-Br, 4-SnMe.sub.3, 6-Br 1739 Bu--F Et 2-SnMe.sub.3, 4-Br, 6-Br 1740 Bu--F Et 2-Br, 4-Br, 6-Me 1741 Bu--F Et 2-Br, 4-CF.sub.3, 6-Br 1742 Bu--F Et 2-Br, 4-Br, 6-CF.sub.3 1743 Bu--F Et 2-CF.sub.3, 4-CF.sub.3 1744 Bu--F Et 2-Cl, 4-CF.sub.3 1745 Bu--F Et 2-CF.sub.3, 4-Cl 1746 Bu--F Et 2-Br, 4-CF.sub.3 1747 Bu--F Et 2-SnMe.sub.3, 4-CF.sub.3 1748 Bu--F Et 2-Me, 4-CF.sub.3 1749 Bu--F Et 2-CF.sub.3, 4-Br 1750 Bu--F Et 2-CF.sub.3, 4-SnMe.sub.3 1751 Bu--F Et 2-CF.sub.3, 4-Me 1752 Bu--F Et 2-Br, 4-OH 1753 Bu--F Et 2-Br, 4-OMe 1754 Bu--F Et 2-Br, 4-OMeF 1755 Bu--F Et 2-Br, 4-OCF.sub.3 1756 Bu--F Et 2-Br, 4-OEtF 1757 Bu--F Et 2-Br, 4-OPrF 1758 Bu--F Et 2-OH, 4-Br 1759 Bu--F Et 2-OMe, 4-Br 1760 Bu--F Et 2-OMeF, 4-Br 1761 Bu--F Et 2-OCF.sub.3, 4-Br 1762 Bu--F Et 2-OEtF, 4-Br 1763 Bu--F Et 2-OPrF, 4-Br 1764 Bu--F Et 2-I, 4-OH 1765 Bu--F Et 2-I, 4-OMe 1766 Bu--F Et 2-I, 4-OMeF 1767 Bu--F Et 2-I, 4-OCF.sub.3 1768 Bu--F Et 2-I, 4-OEtF 1769 Bu--F Et 2-I, 4-OPrF 1770 Bu--F Et 2-OH, 4-I 1771 Bu--F Et 2-OMe, 4-I 1772 Bu--F Et 2-OMeF, 4-I 1773 Bu--F Et 2-OCF.sub.3, 4-I 1774 Bu--F Et 2-OEtF, 4-I 1775 Bu--F Et 2-OPrF, 4-I 1776 Bu--F Et 2-SnMe.sub.3, 4-OH 1777 Bu--F Et 2-SnMe.sub.3, 4-OMe 1778 Bu--F Et 2-SnMe.sub.3, 4- OMeF 1779 Bu--F Et 2-SnMe.sub.3, 4-OCF.sub.3 1780 Bu--F Et 2-SnMe.sub.3, 4-OEtF 1781 Bu--F Et 2-SnMe.sub.3, 4-OPrF 1782 Bu--F Et 2-OH, 4-SnMe.sub.3 1783 Bu--F Et 2-OMe, 4-SnMe.sub.3 1784 Bu--F Et 2-OMeF, 4- SnMe.sub.3 I785 Bu--F Et 2-OCF.sub.3, 4-SnMe.sub.3 1786 Bu--F Et 2-OEtF, 4-SnMe.sub.3 1787 Bu--F Et 2-OPrF, 4-SnMe.sub.3 1788 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H 1789 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-t-Bu 1790 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br 1791 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Br 1792 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br 1793 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I 1794 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-I 1795 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-I 1796 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3 1797 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SnMe.sub.3 1798 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SnMe.sub.3 1799 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me 1800 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Me 1801 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me 1802 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH 1803 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OH 1804 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH 1805 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe 1806 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMe 1807 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe 1808 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF 1809 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMeF 1810 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF 1811 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 1812 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OCF.sub.3 1813 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 1814 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF 1815 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OEtF 1816 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF 1817 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF 1818 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OPrF 1819 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF 1820 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SH 1821 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SH 1822 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SH 1823 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SMe 1824 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SMe 1825 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SMe 1826 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SMeF 1827 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SMeF 1828 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SMeF 1829 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SCF.sub.3 1830 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SCF.sub.3 1831 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SCF.sub.3 1832 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SEtF 1833 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SEtF 1834 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SEtF 1835 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SPrF 1836 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SPrF 1837 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SPrF 1838 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-OMe 1839 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OH 1840 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OMe 1841 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OMeF 1842 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OEtF 1843 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OPrF 1844 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OH 1845 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OMe 1846 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OMeF 1847 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OCF.sub.3 1848 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OEtF 1849 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OPrF 1850 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-Me 1851 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-Me 1852 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-Me 1853 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-Me 1854 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-Me 1855 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-Me 1856 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OH 1857 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OMe 1858 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OMeF 1859 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OCF.sub.3 1860 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OEtF 1861 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OPrF 1862 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-F 1863 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Cl 1864 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-F 1865 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NO.sub.2 1866 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NH.sub.2

1867 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NHMe 1868 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.2 1869 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.3OTf 1870 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.3I 1871 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-F 1872 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NO.sub.2 1873 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NH.sub.2 1874 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NHMe 1875 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.2 1876 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.3OTf 1877 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.3I 1878 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Cl 1879 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Cl 1880 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Cl 1881 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Cl 1882 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-Cl 1883 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-Cl 1884 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Cl 1885 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 5-Cl 1886 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 5-Cl 1887 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 5-Cl 1888 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 5-Cl 1889 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 5-Cl 1890 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 5-Cl 1891 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 5-Cl 1892 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-F 1893 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NO.sub.2 1894 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NH.sub.2 1895 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NHMe 1896 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NMe.sub.2 1897 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- NMe.sub.3OTf 1898 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NMe.sub.3I 1899 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-F 1900 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NO.sub.2 1901 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NH.sub.2 1902 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NHMe 1903 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NMe.sub.2 1904 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5- NMe.sub.3OTf 1905 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NMe.sub.3I 1906 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Br 1907 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Br 1908 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Br 1909 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Br 1910 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-Br 1911 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4- Br 1912 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Br 1913 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-F 1914 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NO.sub.2 1915 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NH.sub.2 1916 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NHMe 1917 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.2 1918 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.3OTf 1919 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.3I 1920 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-I 1921 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-I 1922 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-I 1923 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-I 1924 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-I 1925 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-I 1926 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-I 1927 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-F 1928 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NO.sub.2 1929 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NH.sub.2 1930 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NHMe 1931 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NMe.sub.2 1932 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3- NMe.sub.3OTf 1933 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NMe.sub.3I 1934 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-F 1935 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NO.sub.2 1936 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NH.sub.2 1937 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NHMe 1938 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NMe.sub.2 1939 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4- NMe.sub.3OTf 1940 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NMe.sub.3I 1941 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-F 1942 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NO.sub.2 1943 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NH.sub.2 1944 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NHMe 1945 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NMe.sub.2 1946 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5- NMe.sub.3OTf 1947 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NMe.sub.3I 1948 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Me 1949 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Me 1950 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Me 1951 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Me 1952 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-Me 1953 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3, 4-Me 1954 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4- Me 1955 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Me 1956 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-F 1957 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 5-F 1958 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-SnMe.sub.3 1959 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-F 1960 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4- NO.sub.2 1961 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4- NH.sub.2 1962 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4- NHMe 1963 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4- NMe.sub.2 1964 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl 4- NMe.sub.3OTf 1965 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4- NMe.sub.3I 1966 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Cl, 4-F 1967 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 6-Cl, 4- F 1968 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Me 1969 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Br 1970 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-SnMe.sub.3 1971 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Cl 1972 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Cl 1973 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Cl 1974 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br 1975 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me 1976 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-SnMe.sub.3 1977 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Br 1978 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Br 1979 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-SnMe.sub.3 1980 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Me 1981 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Me 1982 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-Br 1983 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-SnMe.sub.3 1984 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-Me 1985 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Me, 6-Me 1986 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Br, 6-Me 1987 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-SnMe.sub.3, 6-Me 1988 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 6-Me 1989 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-i-Pr 1990 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-i-Pr 1991 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-i-Pr 1992 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-Br 1993 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me, 6-Br 1994 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-SnMe.sub.3, 6-Br 1995 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Br, 6-Br 1996 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-Me 1997 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3, 6-Br 1998 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-CF.sub.3 1999 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-CF.sub.3 2000 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-CF.sub.3 2001 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Cl 2002 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 2003 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-CF.sub.3 2004 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-CF.sub.3 2005 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br 2006 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-SnMe.sub.3 2007 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Me 2008 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OH 2009 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OMe 2010 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OMeF 2011 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OCF.sub.3 2012 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OEtF 2013 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OPrF 2014 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-Br 2015 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-Br 2016 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-Br 2017 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-Br 2018 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-Br 2019 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-Br 2020 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OH 2021 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OMe 2022 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OMeF 2023 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OCF.sub.3 2024 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OEtF 2025 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OPrF 2026 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-I 2027 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-I 2028 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-I 2029 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-I 2030 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-I 2031 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-I 2032 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OH 2033 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OMe 2034 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4- OMeF 2035 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OCF.sub.3 2036 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OEtF 2037 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OPrF 2038 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-SnMe.sub.3 2039 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-SnMe.sub.3 2040 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4- SnMe.sub.3 2041 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-SnMe.sub.3 2042 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-SnMe.sub.3 2043 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-SnMe.sub.3 2044 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H 2045 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-t-Bu 2046 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br 2047 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Br 2048 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br 2049 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I 2050 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-I 2051 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-I 2052 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3 2053 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SnMe.sub.3 2054 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SnMe.sub.3 2055 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me 2056 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Me 2057 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me 2058 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH 2059 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OH 2060 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH 2061 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe 2062 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMe 2063 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe 2064 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF 2065 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMeF 2066 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF 2067 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 2068 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OCF.sub.3 2069 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 2070 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF 2071 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OEtF 2072 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF 2073 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF 2074 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OPrF 2075 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF 2076 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SH 2077 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SH 2078 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SH 2079 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SMe 2080 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SMe 2081 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SMe 2082 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SMeF 2083 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SMeF 2084 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SMeF 2085 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SCF.sub.3 2086 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SCF.sub.3 2087 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SCF.sub.3 2088 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SEtF 2089 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SEtF 2090 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SEtF 2091 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SPrF 2092 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SPrF 2093 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SPrF 2094 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-OMe 2095 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OH 2096 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OMe 2097 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OMeF 2098 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OEtF

2099 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OPrF 2100 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OH 2101 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OMe 2102 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OMeF 2103 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OCF.sub.3 2104 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OEtF 2105 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OPrF 2106 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-Me 2107 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-Me 2108 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-Me 2109 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-Me 2110 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-Me 2111 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-Me 2112 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OH 2113 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OMe 2114 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OMeF 2115 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OCF.sub.3 2116 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OEtF 2117 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OPrF 2118 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-F 2119 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Cl 2120 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-F 2121 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NO.sub.2 2122 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NH.sub.2 2123 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NHMe 2124 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.2 2125 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.3OTf 2126 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.3I 2127 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-F 2128 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NO.sub.2 2129 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NH.sub.2 2130 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NHMe 2131 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.2 2132 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.3OTf 2133 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.3I 2134 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Cl 2135 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Cl 2136 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Cl 2137 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Cl 2138 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-Cl 2139 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-Cl 2140 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Cl 2141 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 5-Cl 2142 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 5-Cl 2143 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 5-Cl 2144 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 5-Cl 2145 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 5-Cl 2146 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 5-Cl 2147 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 5-Cl 2148 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-F 2149 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NO.sub.2 2150 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NH.sub.2 2151 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NHMe 2152 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NMe.sub.2 2153 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- NMe.sub.3OTf 2154 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NMe.sub.3I 2155 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-F 2156 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NO.sub.2 2157 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NH.sub.2 2158 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NHMe 2159 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NMe.sub.2 2160 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5- NMe.sub.3OTf 2161 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NMe.sub.3I 2162 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Br 2163 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Br 2164 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Br 2165 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Br 2166 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-Br 2167 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4- Br 2168 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Br 2169 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-F 2170 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NO.sub.2 2171 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NH.sub.2 2172 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NHMe 2173 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.2 2174 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.3OTf 2175 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.3I 2176 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-I 2177 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-I 2178 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-I 2179 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-I 2180 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-I 2181 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-I 2182 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-I 2183 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-F 2184 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NO.sub.2 2185 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NH.sub.2 2186 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NHMe 2187 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NMe.sub.2 2188 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3- NMe.sub.3OTf 2189 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NMe.sub.3I 2190 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-F 2191 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NO.sub.2 2192 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NH.sub.2 2193 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NHMe 2194 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NMe.sub.2 2195 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4- NMe.sub.3OTf 2196 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NMe.sub.3I 2197 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-F 2198 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NO.sub.2 2199 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NH.sub.2 2200 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NHMe 2201 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NMe.sub.2 2202 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5- NMe.sub.3OTf 2203 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NMe.sub.3I 2204 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Me 2205 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Me 2206 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Me 2207 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Me 2208 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-Me 2209 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3, 4-Me 2210 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4- Me 2211 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Me 2212 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-F 2213 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 5-F 2214 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-SnMe.sub.3 2215 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-F 2216 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4- NO.sub.2 2217 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4- NH.sub.2 2218 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4- NHMe 2219 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4- NMe.sub.2 2220 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl 4- NMe.sub.3OTf 2221 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4- NMe.sub.3I 2222 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Cl, 4-F 2223 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 6-Cl, 4- F 2224 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Me 2225 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Br 2226 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-SnMe.sub.3 2227 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Cl 2228 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Cl 2229 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Cl 2230 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br 2231 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me 2232 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-SnMe.sub.3 2233 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Br 2234 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Br 2235 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-SnMe.sub.3 2236 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Me 2237 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Me 2238 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-Br 2239 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-SnMe.sub.3 2240 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-Me 2241 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Me, 6-Me 2242 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Br, 6-Me 2243 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-SnMe.sub.3, 6-Me 2244 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 6-Me 2245 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-i-Pr 2246 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-i-Pr 2247 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-i-Pr 2248 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-Br 2249 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me, 6-Br 2250 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-SnMe.sub.3, 6-Br 2251 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Br, 6-Br 2252 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-Me 2253 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3, 6-Br 2254 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-CF.sub.3 2255 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-CF.sub.3 2256 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-CF.sub.3 2257 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Cl 2258 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 2259 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-CF.sub.3 2260 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-CF.sub.3 2261 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br 2262 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-SnMe.sub.3 2263 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Me 2264 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OH 2265 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OMe 2266 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OMeF 2267 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OCF.sub.3 2268 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OEtF 2269 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OPrF 2270 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-Br 2271 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-Br 2272 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-Br 2273 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-Br 2274 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-Br 2275 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-Br 2276 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OH 2277 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OMe 2278 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OMeF 2279 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OCF.sub.3 2280 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OEtF 2281 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OPrF 2282 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-I 2283 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-I 2284 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-I 2285 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-I 2286 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-I 2287 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-I 2288 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OH 2289 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OMe 2290 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4- OMeF 2291 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OCF.sub.3 2292 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OEtF 2293 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OPrF 2294 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-SnMe.sub.3 2295 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-SnMe.sub.3 2296 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4- SnMe.sub.3 2297 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-SnMe.sub.3 2298 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-SnMe.sub.3 2299 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-SnMe.sub.3 2300 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H 2301 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-t-Bu 2302 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br 2303 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-Br 2304 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br 2305 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I 2306 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-I 2307 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-I 2308 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3 2309 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SnMe.sub.3 2310 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SnMe.sub.3 2311 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me 2312 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-Me 2313 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me 2314 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH 2315 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OH 2316 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH 2317 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe 2318 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OMe 2319 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe 2320 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF 2321 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OMeF 2322 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF 2323 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 2324 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OCF.sub.3 2325 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 2326 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF 2327 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OEtF 2328 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF 2329 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF 2330 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OPrF

2331 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF 2332 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SH 2333 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SH 2334 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SH 2335 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SMe 2336 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SMe 2337 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SMe 2338 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SMeF 2339 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SMeF 2340 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SMeF 2341 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SCF.sub.3 2342 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SCF.sub.3 2343 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SCF.sub.3 2344 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SEtF 2345 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SEtF 2346 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SEtF 2347 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SPrF 2348 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SPrF 2349 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SPrF 2350 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, 4-OMe 2351 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-OH 2352 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-OMe 2353 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-OMeF 2354 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-OEtF 2355 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-OPrF 2356 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OH 2357 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OMe 2358 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OMeF 2359 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OCF.sub.3 2360 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OEtF 2361 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-OPrF 2362 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH, 4-Me 2363 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, 4-Me 2364 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF, 4-Me 2365 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3, 4-Me 2366 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF, 4-Me 2367 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF, 4-Me 2368 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OH 2369 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OMe 2370 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OMeF 2371 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OCF.sub.3 2372 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OEtF 2373 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-OPrF 2374 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-F 2375 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-Cl 2376 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-F 2377 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NO.sub.2 2378 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NH.sub.2 2379 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NHMe 2380 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NMe.sub.2 2381 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NMe.sub.3OTf 2382 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-NMe.sub.3I 2383 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-F 2384 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NO.sub.2 2385 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NH.sub.2 2386 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NHMe 2387 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NMe.sub.2 2388 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NMe.sub.3OTf 2389 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 5-NMe.sub.3I 2390 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-Cl 2391 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NO.sub.2, 4-Cl 2392 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NH.sub.2, 4-Cl 2393 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NHMe, 4-Cl 2394 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.2, 4-Cl 2395 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3OTf, 4-Cl 2396 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3I, 4-Cl 2397 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 5-Cl 2398 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NO.sub.2, 5-Cl 2399 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NH.sub.2, 5-Cl 2400 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NHMe, 5-Cl 2401 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.2, 5-Cl 2402 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3OTf, 5-Cl 2403 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3I, 5-Cl 2404 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-F 2405 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-NO.sub.2 2406 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-NH.sub.2 2407 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-NHMe 2408 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-NMe.sub.2 2409 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- NMe.sub.3OTf 2410 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-NMe.sub.3I 2411 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-F 2412 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-NO.sub.2 2413 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-NH.sub.2 2414 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-NHMe 2415 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-NMe.sub.2 2416 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5- NMe.sub.3OTf 2417 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 5-NMe.sub.3I 2418 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-Br 2419 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NO.sub.2, 4-Br 2420 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NH.sub.2, 4-Br 2421 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NHMe, 4-Br 2422 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.2, 4-Br 2423 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3OTf, 4- Br 2424 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3I, 4-Br 2425 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-F 2426 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NO.sub.2 2427 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NH.sub.2 2428 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NHMe 2429 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NMe.sub.2 2430 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NMe.sub.3OTf 2431 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-NMe.sub.3I 2432 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-I 2433 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NO.sub.2, 4-I 2434 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NH.sub.2, 4-I 2435 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NHMe, 4-I 2436 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.2, 4-I 2437 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3OTf, 4-I 2438 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3I, 4-I 2439 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-F 2440 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-NO.sub.2 2441 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-NH.sub.2 2442 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-NHMe 2443 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-NMe.sub.2 2444 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3- NMe.sub.3OTf 2445 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 3-NMe.sub.3I 2446 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-F 2447 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-NO.sub.2 2448 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-NH.sub.2 2449 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-NHMe 2450 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-NMe.sub.2 2451 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4- NMe.sub.3OTf 2452 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-NMe.sub.3I 2453 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-F 2454 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-NO.sub.2 2455 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-NH.sub.2 2456 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-NHMe 2457 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-NMe.sub.2 2458 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5- NMe.sub.3OTf 2459 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 5-NMe.sub.3I 2460 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-Me 2461 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NO.sub.2, 4-Me 2462 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NH.sub.2, 4-Me 2463 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NHMe, 4-Me 2464 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.2, 4-Me 2465 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3, 4-Me 2466 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3OTf, 4- Me 2467 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-NMe.sub.3I, 4-Me 2468 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-F 2469 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 5-F 2470 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F, 4-SnMe.sub.3 2471 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4-F 2472 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4- NO.sub.2 2473 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4- NH.sub.2 2474 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4- NHMe 2475 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4- NMe.sub.2 2476 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl 4- NMe.sub.3OTf 2477 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6-Cl, 4- NMe.sub.3I 2478 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 6-Cl, 4-F 2479 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 6-Cl, 4- F 2480 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-Me 2481 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-Br 2482 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-SnMe.sub.3 2483 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Cl 2484 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-Cl 2485 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-Cl 2486 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br 2487 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Me 2488 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-SnMe.sub.3 2489 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-Br 2490 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-Br 2491 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-SnMe.sub.3 2492 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-Me 2493 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-Me 2494 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et, 4-Br 2495 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et, 4-SnMe.sub.3 2496 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et, 4-Me 2497 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-Me, 6-Me 2498 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-Br, 6-Me 2499 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-SnMe.sub.3, 6-Me 2500 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et, 6-Me 2501 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-i-Pr 2502 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-i-Pr 2503 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-i-Pr 2504 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br, 6-Br 2505 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Me, 6-Br 2506 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-SnMe.sub.3, 6-Br 2507 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-Br, 6-Br 2508 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br, 6-Me 2509 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-CF.sub.3, 6-Br 2510 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br, 6-CF.sub.3 2511 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4-CF.sub.3 2512 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-CF.sub.3 2513 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4-Cl 2514 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-CF.sub.3 2515 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-CF.sub.3 2516 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, 4-CF.sub.3 2517 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4-Br 2518 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4-SnMe.sub.3 2519 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4-Me 2520 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OH 2521 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OMe 2522 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OMeF 2523 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OCF.sub.3 2524 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OEtF 2525 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-OPrF 2526 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH, 4-Br 2527 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, 4-Br 2528 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF, 4-Br 2529 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3, 4-Br 2530 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF, 4-Br 2531 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF, 4-Br 2532 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OH 2533 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OMe 2534 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OMeF 2535 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OCF.sub.3 2536 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OEtF 2537 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-I, 4-OPrF 2538 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH, 4-I 2539 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, 4-I 2540 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF, 4-I 2541 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3, 4-I 2542 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF, 4-I 2543 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF, 4-I 2544 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-OH 2545 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-OMe 2546 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4- OMeF 2547 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-OCF.sub.3 2548 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-OEtF 2549 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3, 4-OPrF 2550 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH, 4-SnMe.sub.3 2551 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, 4-SnMe.sub.3 2552 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF, 4- SnMe.sub.3 2553 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3, 4-SnMe.sub.3 2554 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF, 4-SnMe.sub.3 2555 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF, 4-SnMe.sub.3

TABLE-US-00017 TABLE 2 Substituent list for compounds of general structure VII. VII ##STR00088## Compound # R.sup.1 = R.sup.2 = R.sup.4 = X.sup.2 = 2556 Bu Et H H 2557 Bu Et H SnMe.sub.3 2558 Bu Et H Br 2559 Bu Et H I 2560 Bu Et 4-F H 2561 Bu Et 4-F SnMe.sub.3 2562 Bu Et 4-F Br 2563 Bu Et 4-F I 2564 Bu Et 5-F H 2565 Bu Et 5-F SnMe.sub.3 2566 Bu Et 5-F Br 2567 Bu Et 5-F I 2568 Bu Et 4-Cl H 2569 Bu Et 4-Cl SnMe.sub.3 2570 Bu Et 4-Cl Br 2571 Bu Et 4-Cl I 2572 Bu Et 4-Br H 2573 Bu Et 4-Br SnMe.sub.3 2574 Bu Et 4-Br Br 2575 Bu Et 4-Br I 2576 Bu Et 4-Me H 2577 Bu Et 4-Me SnMe.sub.3 2578 Bu Et 4-Me Br 2579 Bu Et 4-Me I 2580 Bu Et 4-CF.sub.3 H 2581 Bu Et 4-CF.sub.3 SnMe.sub.3 2582 Bu Et 4-CF.sub.3 Br 2583 Bu Et 4-CF.sub.3 I 2584 Bu Et 4-OH H 2585 Bu Et 4-OH SnMe.sub.3 2586 Bu Et 4-OH Br 2587 Bu Et 4-OH I 2588 Bu Et 4-OMe H 2589 Bu Et 4-OMe SnMe.sub.3 2590 Bu Et 4-OMe Br 2591 Bu Et 4-OMe I 2592 Bu Et 4-OMeF H 2593 Bu Et 4-OMeF SnMe.sub.3 2594 Bu Et 4-OMeF Br 2595 Bu Et 4-OMeF I 2596 Bu Et 4-OCF.sub.3 H 2597 Bu Et 4-OCF.sub.3 SnMe.sub.3 2598 Bu Et 4-OCF.sub.3 Br 2599 Bu Et 4-OCF.sub.3 I 2600 Bu Et 4-OEtF H 2601 Bu Et 4-OEtF SnMe.sub.3 2602 Bu Et 4-OEtF Br 2603 Bu Et 4-OEtF I 2604 Bu Et 4-OPrF H 2605 Bu Et 4-OPrF SnMe.sub.3 2606 Bu Et 4-OPrF Br 2607 Bu Et 4-OPrF I 2608 Bu Et 4-i-Pr H 2609 Bu Et 4-i-Pr SnMe.sub.3 2610 Bu Et 4-i-Pr Br 2611 Bu Et 4-i-Pr I 2612 Bu Et 2-Br, 4-CF.sub.3 H 2613 Bu Et 2-Br, 4-CF.sub.3 SnMe.sub.3 2614 Bu Et 2-Br, 4-CF.sub.3 Br 2615 Bu Et 2-Br, 4-CF.sub.3 I 2616 Bu Et 2-CF.sub.3, 4-Br H 2617 Bu Et 2-CF.sub.3, 4-Br SnMe.sub.3 2618 Bu Et 2-CF.sub.3, 4-Br Br 2619 Bu Et 2-CF.sub.3, 4-Br I 2620 Bu Et 2-Br, 4-Br H 2621 Bu Et 2-Br, 4-Br SnMe.sub.3 2622 Bu Et 2-Br, 4-Br Br 2623 Bu Et 2-Br, 4-Br I 2624 Bu Et 2-Br, 4-Me H 2625 Bu Et 2-Br, 4-Me SnMe.sub.3 2626 Bu Et 2-Br, 4-Me Br 2627 Bu Et 2-Br, 4-Me I 2628 Pr Pr H H 2629 Pr Pr H SnMe.sub.3 2630 Pr Pr H Br 2631 Pr Pr H I 2632 Pr Pr 4-F H 2633 Pr Pr 4-F SnMe.sub.3 2634 Pr Pr 4-F Br 2635 Pr Pr 4-F I 2636 Pr Pr 5-F H 2637 Pr Pr 5-F SnMe.sub.3 2638 Pr Pr 5-F Br 2639 Pr Pr 5-F I 2640 Pr Pr 4-Cl H 2641 Pr Pr 4-Cl SnMe.sub.3 2642 Pr Pr 4-Cl Br 2643 Pr Pr 4-Cl I 2644 Pr Pr 4-Br H 2645 Pr Pr 4-Br SnMe.sub.3 2646 Pr Pr 4-Br Br 2647 Pr Pr 4-Br I 2648 Pr Pr 4-Me H 2649 Pr Pr 4-Me SnMe.sub.3 2650 Pr Pr 4-Me Br 2651 Pr Pr 4-Me I 2652 Pr Pr 4-CF.sub.3 H 2653 Pr Pr 4-CF.sub.3 SnMe.sub.3 2654 Pr Pr 4-CF.sub.3 Br 2655 Pr Pr 4-CF.sub.3 I 2656 Pr Pr 4-OH H 2657 Pr Pr 4-OH SnMe.sub.3 2658 Pr Pr 4-OH Br 2659 Pr Pr 4-OH I 2660 Pr Pr 4-OMe H 2661 Pr Pr 4-OMe SnMe.sub.3 2662 Pr Pr 4-OMe Br 2663 Pr Pr 4-OMe I 2664 Pr Pr 4-OMeF H 2665 Pr Pr 4-OMeF SnMe.sub.3 2666 Pr Pr 4-OMeF Br 2667 Pr Pr 4-OMeF I 2668 Pr Pr 4-OCF.sub.3 H 2669 Pr Pr 4-OCF.sub.3 SnMe.sub.3 2670 Pr Pr 4-OCF.sub.3 Br 2671 Pr Pr 4-OCF.sub.3 I 2672 Pr Pr 4-OEtF H 2673 Pr Pr 4-OEtF SnMe.sub.3 2674 Pr Pr 4-OEtF Br 2675 Pr Pr 4-OEtF I 2676 Pr Pr 4-OPrF H 2677 Pr Pr 4-OPrF SnMe.sub.3 2678 Pr Pr 4-OPrF Br 2679 Pr Pr 4-OPrF I 2680 Pr Pr 4-i-Pr H 2681 Pr Pr 4-i-Pr SnMe.sub.3 2682 Pr Pr 4-i-Pr Br 2683 Pr Pr 4-i-Pr I 2684 Pr Pr 2-Br, 4-CF.sub.3 H 2685 Pr Pr 2-Br, 4-CF.sub.3 SnMe.sub.3 2686 Pr Pr 2-Br, 4-CF.sub.3 Br 2687 Pr Pr 2-Br, 4-CF.sub.3 I 2688 Pr Pr 2-CF.sub.3, 4-Br H 2689 Pr Pr 2-CF.sub.3, 4-Br SnMe.sub.3 2690 Pr Pr 2-CF.sub.3, 4-Br Br 2691 Pr Pr 2-CF.sub.3, 4-Br I 2692 Pr Pr 2-Br, 4-Br H 2693 Pr Pr 2-Br, 4-Br SnMe.sub.3 2694 Pr Pr 2-Br, 4-Br Br 2695 Pr Pr 2-Br, 4-Br I 2696 Pr Pr 2-Br, 4-Me H 2697 Pr Pr 2-Br, 4-Me SnMe.sub.3 2698 Pr Pr 2-Br, 4-Me Br 2699 Pr Pr 2-Br, 4-Me I 2700 Pr Pr-F H H 2701 Pr Pr-F H SnMe.sub.3 2702 Pr Pr-F H Br 2703 Pr Pr-F H I 2704 Pr Pr-F 4-F H 2705 Pr Pr-F 4-F SnMe.sub.3 2706 Pr Pr-F 4-F Br 2707 Pr Pr-F 4-F I 2708 Pr Pr-F 5-F H 2709 Pr Pr-F 5-F SnMe.sub.3 2710 Pr Pr-F 5-F Br 2711 Pr Pr-F 5-F I 2712 Pr Pr-F 4-Cl H 2713 Pr Pr-F 4-Cl SnMe.sub.3 2714 Pr Pr-F 4-Cl Br 2715 Pr Pr-F 4-Cl I 2716 Pr Pr-F 4-Br H 2717 Pr Pr-F 4-Br SnMe.sub.3 2718 Pr Pr-F 4-Br Br 2719 Pr Pr-F 4-Br I 2720 Pr Pr-F 4-Me H 2721 Pr Pr-F 4-Me SnMe.sub.3 2722 Pr Pr-F 4-Me Br 2723 Pr Pr-F 4-Me I 2724 Pr Pr-F 4-CF.sub.3 H 2725 Pr Pr-F 4-CF.sub.3 SnMe.sub.3 2726 Pr Pr-F 4-CF.sub.3 Br 2727 Pr Pr-F 4-CF.sub.3 I 2728 Pr Pr-F 4-OH H 2729 Pr Pr-F 4-OH SnMe.sub.3 2730 Pr Pr-F 4-OH Br 2731 Pr Pr-F 4-OH I 2732 Pr Pr-F 4-OMe H 2733 Pr Pr-F 4-OMe SnMe.sub.3 2734 Pr Pr-F 4-OMe Br 2735 Pr Pr-F 4-OMe I 2736 Pr Pr-F 4-OMeF H 2737 Pr Pr-F 4-OMeF SnMe.sub.3 2738 Pr Pr-F 4-OMeF Br 2739 Pr Pr-F 4-OMeF I 2740 Pr Pr-F 4-OCF.sub.3 H 2741 Pr Pr-F 4-OCF.sub.3 SnMe.sub.3 2742 Pr Pr-F 4-OCF.sub.3 Br 2743 Pr Pr-F 4-OCF.sub.3 I 2744 Pr Pr-F 4-OEtF H 2745 Pr Pr-F 4-OEtF SnMe.sub.3 2746 Pr Pr-F 4-OEtF Br 2747 Pr Pr-F 4-OEtF I 2748 Pr Pr-F 4-OPrF H 2749 Pr Pr-F 4-OPrF SnMe.sub.3 2750 Pr Pr-F 4-OPrF Br 2751 Pr Pr-F 4-OPrF I 2752 Pr Pr-F 4-i-Pr H 2753 Pr Pr-F 4-i-Pr SnMe.sub.3 2754 Pr Pr-F 4-i-Pr Br 2755 Pr Pr-F 4-i-Pr I 2756 Pr Pr-F 2-Br, 4-CF.sub.3 H 2757 Pr Pr-F 2-Br, 4-CF.sub.3 SnMe.sub.3 2758 Pr Pr-F 2-Br, 4-CF.sub.3 Br 2759 Pr Pr-F 2-Br, 4-CF.sub.3 I 2760 Pr Pr-F 2-CF.sub.3, 4-Br H 2761 Pr Pr-F 2-CF.sub.3, 4-Br SnMe.sub.3 2762 Pr Pr-F 2-CF.sub.3, 4-Br Br 2763 Pr Pr-F 2-CF.sub.3, 4-Br I 2764 Pr Pr-F 2-Br, 4-Br H 2765 Pr Pr-F 2-Br, 4-Br SnMe.sub.3 2766 Pr Pr-F 2-Br, 4-Br Br 2767 Pr Pr-F 2-Br, 4-Br I 2768 Pr Pr-F 2-Br, 4-Me H 2769 Pr Pr-F 2-Br, 4-Me SnMe.sub.3 2770 Pr Pr-F 2-Br, 4-Me Br 2771 Pr Pr-F 2-Br, 4-Me I 2772 Pr Et-F H H 2773 Pr Et-F H SnMe.sub.3 2774 Pr Et-F H Br 2775 Pr Et-F H I 2776 Pr Et-F 4-F H 2777 Pr Et-F 4-F SnMe.sub.3 2778 Pr Et-F 4-F Br 2779 Pr Et-F 4-F I 2780 Pr Et-F 5-F H 2781 Pr Et-F 5-F SnMe.sub.3 2782 Pr Et-F 5-F Br 2783 Pr Et-F 5-F I 2784 Pr Et-F 4-Cl H 2785 Pr Et-F 4-Cl SnMe.sub.3 2786 Pr Et-F 4-Cl Br 2787 Pr Et-F 4-Cl I 2788 Pr Et-F 4-Br H 2789 Pr Et-F 4-Br SnMe.sub.3 2790 Pr Et-F 4-Br Br 2791 Pr Et-F 4-Br I 2792 Pr Et-F 4-Me H 2793 Pr Et-F 4-Me SnMe.sub.3 2794 Pr Et-F 4-Me Br 2795 Pr Et-F 4-Me I 2796 Pr Et-F 4-CF.sub.3 H 2797 Pr Et-F 4-CF.sub.3 SnMe.sub.3

2798 Pr Et-F 4-CF.sub.3 Br 2799 Pr Et-F 4-CF.sub.3 I 2800 Pr Et-F 4-OH H 2801 Pr Et-F 4-OH SnMe.sub.3 2802 Pr Et-F 4-OH Br 2803 Pr Et-F 4-OH I 2804 Pr Et-F 4-OMe H 2805 Pr Et-F 4-OMe SnMe.sub.3 2806 Pr Et-F 4-OMe Br 2807 Pr Et-F 4-OMe I 2808 Pr Et-F 4-OMeF H 2809 Pr Et-F 4-OMeF SnMe.sub.3 2810 Pr Et-F 4-OMeF Br 2811 Pr Et-F 4-OMeF I 2812 Pr Et-F 4-OCF.sub.3 H 2813 Pr Et-F 4-OCF.sub.3 SnMe.sub.3 2814 Pr Et-F 4-OCF.sub.3 Br 2815 Pr Et-F 4-OCF.sub.3 I 2816 Pr Et-F 4-OEtF H 2817 Pr Et-F 4-OEtF SnMe.sub.3 2818 Pr Et-F 4-OEtF Br 2819 Pr Et-F 4-OEtF I 2820 Pr Et-F 4-OPrF H 2821 Pr Et-F 4-OPrF SnMe.sub.3 2822 Pr Et-F 4-OPrF Br 2823 Pr Et-F 4-OPrF I 2824 Pr Et-F 4-i-Pr H 2825 Pr Et-F 4-i-Pr SnMe.sub.3 2826 Pr Et-F 4-i-Pr Br 2827 Pr Et-F 4-i-Pr I 2828 Pr Et-F 2-Br, 4-CF.sub.3 H 2829 Pr Et-F 2-Br, 4-CF.sub.3 SnMe.sub.3 2830 Pr Et-F 2-Br, 4-CF.sub.3 Br 2831 Pr Et-F 2-Br, 4-CF.sub.3 I 2832 Pr Et-F 2-CF.sub.3, 4-Br H 2833 Pr Et-F 2-CF.sub.3, 4-Br SnMe.sub.3 2834 Pr Et-F 2-CF.sub.3, 4-Br Br 2835 Pr Et-F 2-CF.sub.3, 4-Br I 2836 Pr Et-F 2-Br, 4-Br H 2837 Pr Et-F 2-Br, 4-Br SnMe.sub.3 2838 Pr Et-F 2-Br, 4-Br Br 2839 Pr Et-F 2-Br, 4-Br I 2840 Pr Et-F 2-Br, 4-Me H 2841 Pr Et-F 2-Br, 4-Me SnMe.sub.3 2842 Pr Et-F 2-Br, 4-Me Br 2843 Pr Et-F 2-Br, 4-Me I 2844 Pr-F Et H H 2845 Pr-F Et H SnMe.sub.3 2846 Pr-F Et H Br 2847 Pr-F Et H I 2848 Pr-F Et 4-F H 2849 Pr-F Et 4-F SnMe.sub.3 2850 Pr-F Et 4-F Br 2851 Pr-F Et 4-F I 2852 Pr-F Et 5-F H 2853 Pr-F Et 5-F SnMe.sub.3 2854 Pr-F Et 5-F Br 2855 Pr-F Et 5-F I 2856 Pr-F Et 4-Cl H 2857 Pr-F Et 4-Cl SnMe.sub.3 2858 Pr-F Et 4-Cl Br 2859 Pr-F Et 4-Cl I 2860 Pr-F Et 4-Br H 2861 Pr-F Et 4-Br SnMe.sub.3 2862 Pr-F Et 4-Br Br 2863 Pr-F Et 4-Br I 2864 Pr-F Et 4-Me H 2865 Pr-F Et 4-Me SnMe.sub.3 2866 Pr-F Et 4-Me Br 2867 Pr-F Et 4-Me I 2868 Pr-F Et 4-CF.sub.3 H 2869 Pr-F Et 4-CF.sub.3 SnMe.sub.3 2870 Pr-F Et 4-CF.sub.3 Br 2871 Pr-F Et 4-CF.sub.3 I 2872 Pr-F Et 4-OH H 2873 Pr-F Et 4-OH SnMe.sub.3 2874 Pr-F Et 4-OH Br 2875 Pr-F Et 4-OH I 2876 Pr-F Et 4-OMe H 2877 Pr-F Et 4-OMe SnMe.sub.3 2878 Pr-F Et 4-OMe Br 2879 Pr-F Et 4-OMe I 2880 Pr-F Et 4-OMeF H 2881 Pr-F Et 4-OMeF SnMe.sub.3 2882 Pr-F Et 4-OMeF Br 2883 Pr-F Et 4-OMeF I 2884 Pr-F Et 4-OCF.sub.3 H 2885 Pr-F Et 4-OCF.sub.3 SnMe.sub.3 2886 Pr-F Et 4-OCF.sub.3 Br 2887 Pr-F Et 4-OCF.sub.3 I 2888 Pr-F Et 4-OEtF H 2889 Pr-F Et 4-OEtF SnMe.sub.3 2890 Pr-F Et 4-OEtF Br 2891 Pr-F Et 4-OEtF I 2892 Pr-F Et 4-OPrF H 2893 Pr-F Et 4-OPrF SnMe.sub.3 2894 Pr-F Et 4-OPrF Br 2895 Pr-F Et 4-OPrF I 2896 Pr-F Et 4-i-Pr H 2897 Pr-F Et 4-i-Pr SnMe.sub.3 2898 Pr-F Et 4-i-Pr Br 2899 Pr-F Et 4-i-Pr I 2900 Pr-F Et 2-Br, 4-CF.sub.3 H 2901 Pr-F Et 2-Br, 4-CF.sub.3 SnMe.sub.3 2902 Pr-F Et 2-Br, 4-CF.sub.3 Br 2903 Pr-F Et 2-Br, 4-CF.sub.3 I 2904 Pr-F Et 2-CF.sub.3, 4-Br H 2905 Pr-F Et 2-CF.sub.3, 4-Br SnMe.sub.3 2906 Pr-F Et 2-CF.sub.3, 4-Br Br 2907 Pr-F Et 2-CF.sub.3, 4-Br I 2908 Pr-F Et 2-Br, 4-Br H 2909 Pr-F Et 2-Br, 4-Br SnMe.sub.3 2910 Pr-F Et 2-Br, 4-Br Br 2911 Pr-F Et 2-Br, 4-Br I 2912 Pr-F Et 2-Br, 4-Me H 2913 Pr-F Et 2-Br, 4-Me SnMe.sub.3 2914 Pr-F Et 2-Br, 4-Me Br 2915 Pr-F Et 2-Br, 4-Me I 2916 Bu Et-F H H 2917 Bu Et-F H SnMe.sub.3 2918 Bu Et-F H Br 2919 Bu Et-F H I 2920 Bu Et-F 4-F H 2921 Bu Et-F 4-F SnMe.sub.3 2922 Bu Et-F 4-F Br 2923 Bu Et-F 4-F I 2924 Bu Et-F 5-F H 2925 Bu Et-F 5-F SnMe.sub.3 2926 Bu Et-F 5-F Br 2927 Bu Et-F 5-F I 2928 Bu Et-F 4-Cl H 2929 Bu Et-F 4-Cl SnMe.sub.3 2930 Bu Et-F 4-Cl Br 2931 Bu Et-F 4-Cl I 2932 Bu Et-F 4-Br H 2933 Bu Et-F 4-Br SnMe.sub.3 2934 Bu Et-F 4-Br Br 2935 Bu Et-F 4-Br I 2936 Bu Et-F 4-Me H 2937 Bu Et-F 4-Me SnMe.sub.3 2938 Bu Et-F 4-Me Br 2939 Bu Et-F 4-Me I 2940 Bu Et-F 4-CF.sub.3 H 2941 Bu Et-F 4-CF.sub.3 SnMe.sub.3 2942 Bu Et-F 4-CF.sub.3 Br 2943 Bu Et-F 4-CF.sub.3 I 2944 Bu Et-F 4-OH H 2945 Bu Et-F 4-OH SnMe.sub.3 2946 Bu Et-F 4-OH Br 2947 Bu Et-F 4-OH I 2948 Bu Et-F 4-OMe H 2949 Bu Et-F 4-OMe SnMe.sub.3 2950 Bu Et-F 4-OMe Br 2951 Bu Et-F 4-OMe I 2952 Bu Et-F 4-OMeF H 2953 Bu Et-F 4-OMeF SnMe.sub.3 2954 Bu Et-F 4-OMeF Br 2955 Bu Et-F 4-OMeF I 2956 Bu Et-F 4-OCF.sub.3 H 2957 Bu Et-F 4-OCF.sub.3 SnMe.sub.3 2958 Bu Et-F 4-OCF.sub.3 Br 2959 Bu Et-F 4-OCF.sub.3 I 2960 Bu Et-F 4-OEtF H 2961 Bu Et-F 4-OEtF SnMe.sub.3 2962 Bu Et-F 4-OEtF Br 2963 Bu Et-F 4-OEtF I 2964 Bu Et-F 4-OPrF H 2965 Bu Et-F 4-OPrF SnMe.sub.3 2966 Bu Et-F 4-OPrF Br 2967 Bu Et-F 4-OPrF I 2968 Bu Et-F 4-i-Pr H 2969 Bu Et-F 4-i-Pr SnMe.sub.3 2970 Bu Et-F 4-i-Pr Br 2971 Bu Et-F 4-i-Pr I 2972 Bu Et-F 2-Br, 4-CF.sub.3 H 2973 Bu Et-F 2-Br, 4-CF.sub.3 SnMe.sub.3 2974 Bu Et-F 2-Br, 4-CF.sub.3 Br 2975 Bu Et-F 2-Br, 4-CF.sub.3 I 2976 Bu Et-F 2-CF.sub.3, 4-Br H 2977 Bu Et-F 2-CF.sub.3, 4-Br SnMe.sub.3 2978 Bu Et-F 2-CF.sub.3, 4-Br Br 2979 Bu Et-F 2-CF.sub.3, 4-Br I 2980 Bu Et-F 2-Br, 4-Br H 2981 Bu Et-F 2-Br, 4-Br SnMe.sub.3 2982 Bu Et-F 2-Br, 4-Br Br 2983 Bu Et-F 2-Br, 4-Br I 2984 Bu Et-F 2-Br, 4-Me H 2985 Bu Et-F 2-Br, 4-Me SnMe.sub.3 2986 Bu Et-F 2-Br, 4-Me Br 2987 Bu Et-F 2-Br, 4-Me I 2988 Bu-F Et H H 2989 Bu-F Et H SnMe.sub.3 2990 Bu-F Et H Br 2991 Bu-F Et H I 2992 Bu-F Et 4-F H 2993 Bu-F Et 4-F SnMe.sub.3 2994 Bu-F Et 4-F Br 2995 Bu-F Et 4-F I 2996 Bu-F Et 5-F H 2997 Bu-F Et 5-F SnMe.sub.3 2998 Bu-F Et 5-F Br 2999 Bu-F Et 5-F I 3000 Bu-F Et 4-Cl H 3001 Bu-F Et 4-Cl SnMe.sub.3 3002 Bu-F Et 4-Cl Br 3003 Bu-F Et 4-Cl I 3004 Bu-F Et 4-Br H 3005 Bu-F Et 4-Br SnMe.sub.3 3006 Bu-F Et 4-Br Br 3007 Bu-F Et 4-Br I 3008 Bu-F Et 4-Me H 3009 Bu-F Et 4-Me SnMe.sub.3 3010 Bu-F Et 4-Me Br 3011 Bu-F Et 4-Me I 3012 Bu-F Et 4-CF.sub.3 H 3013 Bu-F Et 4-CF.sub.3 SnMe.sub.3 3014 Bu-F Et 4-CF.sub.3 Br 3015 Bu-F Et 4-CF.sub.3 I 3016 Bu-F Et 4-OH H 3017 Bu-F Et 4-OH SnMe.sub.3 3018 Bu-F Et 4-OH Br 3019 Bu-F Et 4-OH I 3020 Bu-F Et 4-OMe H 3021 Bu-F Et 4-OMe SnMe.sub.3 3022 Bu-F Et 4-OMe Br 3023 Bu-F Et 4-OMe I 3024 Bu-F Et 4-OMeF H 3025 Bu-F Et 4-OMeF SnMe.sub.3 3026 Bu-F Et 4-OMeF Br 3027 Bu-F Et 4-OMeF I 3028 Bu-F Et 4-OCF.sub.3 H 3029 Bu-F Et 4-OCF.sub.3 SnMe.sub.3 3030 Bu-F Et 4-OCF.sub.3 Br 3031 Bu-F Et 4-OCF.sub.3 I 3032 Bu-F Et 4-OEtF H 3033 Bu-F Et 4-OEtF SnMe.sub.3 3034 Bu-F Et 4-OEtF Br 3035 Bu-F Et 4-OEtF I 3036 Bu-F Et 4-OPrF H 3037 Bu-F Et 4-OPrF SnMe.sub.3 3038 Bu-F Et 4-OPrF Br 3039 Bu-F Et 4-OPrF I 3040 Bu-F Et 4-i-Pr H 3041 Bu-F Et 4-i-Pr SnMe.sub.3 3042 Bu-F Et 4-i-Pr Br 3043 Bu-F Et 4-i-Pr I 3044 Bu-F Et 2-Br, 4-CF.sub.3 H 3045 Bu-F Et 2-Br, 4-CF.sub.3 SnMe.sub.3 3046 Bu-F Et 2-Br, 4-CF.sub.3 Br 3047 Bu-F Et 2-Br, 4-CF.sub.3 I 3048 Bu-F Et 2-CF.sub.3, 4-Br H

3049 Bu-F Et 2-CF.sub.3, 4-Br SnMe.sub.3 3050 Bu-F Et 2-CF.sub.3, 4-Br Br 3051 Bu-F Et 2-CF.sub.3, 4-Br I 3052 Bu-F Et 2-Br, 4-Br H 3053 Bu-F Et 2-Br, 4-Br SnMe.sub.3 3054 Bu-F Et 2-Br, 4-Br Br 3055 Bu-F Et 2-Br, 4-Br I 3056 Bu-F Et 2-Br, 4-Me H 3057 Bu-F Et 2-Br, 4-Me SnMe.sub.3 3058 Bu-F Et 2-Br, 4-Me Br 3059 Bu-F Et 2-Br, 4-Me I 3060 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H H 3061 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H SnMe.sub.3 3062 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H Br 3063 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H I 3064 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F H 3065 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F SnMe.sub.3 3066 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F Br 3067 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F I 3068 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F H 3069 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F SnMe.sub.3 3070 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F Br 3071 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F I 3072 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl H 3073 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl SnMe.sub.3 3074 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl Br 3075 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl I 3076 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br H 3077 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br SnMe.sub.3 3078 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br Br 3079 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br I 3080 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me H 3081 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me SnMe.sub.3 3082 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me Br 3083 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me I 3084 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 H 3085 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 SnMe.sub.3 3086 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 Br 3087 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 I 3088 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH H 3089 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH SnMe.sub.3 3090 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH Br 3091 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH I 3092 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe H 3093 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe SnMe.sub.3 3094 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe Br 3095 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe I 3096 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF H 3097 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF SnMe.sub.3 3098 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF Br 3099 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF I 3100 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 H 3101 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 SnMe.sub.3 3102 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 Br 3103 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 I 3104 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF H 3105 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF SnMe.sub.3 3106 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF Br 3107 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF I 3108 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF H 3109 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF SnMe.sub.3 3110 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF Br 3111 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF I 3112 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr H 3113 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr SnMe.sub.3 3114 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr Br 3115 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr I 3116 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 H 3117 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 SnMe.sub.3 3118 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 Br 3119 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 I 3120 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br H 3121 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br SnMe.sub.3 3122 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br Br 3123 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br I 3124 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br H 3125 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br SnMe.sub.3 3126 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br Br 3127 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br I 3128 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me H 3129 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me SnMe.sub.3 3130 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me Br 3131 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me I 3132 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H H 3133 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H SnMe.sub.3 3134 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H Br 3135 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H I 3136 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F H 3137 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F SnMe.sub.3 3138 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F Br 3139 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F I 3140 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F H 3141 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F SnMe.sub.3 3142 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F Br 3143 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F I 3144 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl H 3145 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl SnMe.sub.3 3146 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl Br 3147 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl I 3148 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br H 3149 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br SnMe.sub.3 3150 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br Br 3151 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br I 3152 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me H 3153 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me SnMe.sub.3 3154 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me Br 3155 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me I 3156 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 H 3157 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 SnMe.sub.3 3158 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 Br 3159 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 I 3160 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH H 3161 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH SnMe.sub.3 3162 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH Br 3163 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH I 3164 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe H 3165 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe SnMe.sub.3 3166 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe Br 3167 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe I 3168 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF H 3169 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF SnMe.sub.3 3170 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF Br 3171 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF I 3172 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 H 3173 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 SnMe.sub.3 3174 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 Br 3175 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 I 3176 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF H 3177 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF SnMe.sub.3 3178 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF Br 3179 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF I 3180 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF H 3181 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF SnMe.sub.3 3182 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF Br 3183 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF I 3184 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr H 3185 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr SnMe.sub.3 3186 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr Br 3187 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr I 3188 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 H 3189 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 SnMe.sub.3 3190 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 Br 3191 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 I 3192 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br H 3193 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br SnMe.sub.3 3194 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br Br 3195 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br I 3196 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br H 3197 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br SnMe.sub.3 3198 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br Br 3199 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br I 3200 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me H 3201 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me SnMe.sub.3 3202 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me Br 3203 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me I 3204 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H H 3205 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H SnMe.sub.3 3206 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H Br 3207 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H I 3208 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F H 3209 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F SnMe.sub.3 3210 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F Br 3211 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F I 3212 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F H 3213 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F SnMe.sub.3 3214 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F Br 3215 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F I 3216 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl H 3217 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl SnMe.sub.3 3218 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl Br 3219 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl I 3220 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br H 3221 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br SnMe.sub.3 3222 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br Br 3223 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br I 3224 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me H 3225 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me SnMe.sub.3 3226 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me Br 3227 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me I 3228 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 H 3229 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 SnMe.sub.3 3230 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 Br 3231 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 I 3232 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH H 3233 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH SnMe.sub.3 3234 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH Br 3235 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH I 3236 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe H 3237 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe SnMe.sub.3 3238 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe Br 3239 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe I 3240 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF H 3241 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF SnMe.sub.3 3242 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF Br 3243 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF I 3244 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 H 3245 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 SnMe.sub.3 3246 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 Br 3247 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 I 3248 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF H 3249 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF SnMe.sub.3 3250 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF Br 3251 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF I 3252 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF H 3253 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF SnMe.sub.3 3254 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF Br 3255 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF I 3256 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr H 3257 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr SnMe.sub.3 3258 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr Br 3259 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr I 3260 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 H 3261 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 SnMe.sub.3 3262 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 Br 3263 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 I 3264 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br H 3265 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br SnMe.sub.3 3266 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br Br 3267 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br I 3268 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br H 3269 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br SnMe.sub.3 3270 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br Br 3271 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br I 3272 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me H 3273 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me SnMe.sub.3 3274 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me Br 3275 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me I

TABLE-US-00018 TABLE 3 Substituent list for compounds of general structure VIII. VIII ##STR00089## Compound # R.sup.1 = R.sup.2 = R.sup.5 = X.sup.2 = 3276 Bu Et H H 3277 Bu Et H SnMe.sub.3 3278 Bu Et H Br 3279 Bu Et H I 3280 Bu Et 2-F H 3281 Bu Et 2-F SnMe.sub.3 3282 Bu Et 2-F Br 3283 Bu Et 2-F I 3284 Bu Et 2-Cl H 3285 Bu Et 2-Cl SnMe.sub.3 3286 Bu Et 2-Cl Br 3287 Bu Et 2-Cl I 3288 Bu Et 2-Br H 3289 Bu Et 2-Br SnMe.sub.3 3290 Bu Et 2-Br Br 3291 Bu Et 2-Br I 3292 Bu Et 2-Me H 3293 Bu Et 2-Me SnMe.sub.3 3294 Bu Et 2-Me Br 3295 Bu Et 2-Me I 3296 Bu Et 2-Et H 3297 Bu Et 2-Et SnMe.sub.3 3298 Bu Et 2-Et Br 3299 Bu Et 2-Et I 3300 Bu Et 2-Me, 6-Me H 3301 Bu Et 2-Me, 6-Me SnMe.sub.3 3302 Bu Et 2-Me, 6-Me Br 3303 Bu Et 2-Me, 6-Me I 3304 Bu Et 2-OH H 3305 Bu Et 2-OH SnMe.sub.3 3306 Bu Et 2-OH Br 3307 Bu Et 2-OH I 3308 Bu Et 2-OMe H 3309 Bu Et 2-OMe SnMe.sub.3 3310 Bu Et 2-OMe Br 3311 Bu Et 2-OMe I 3312 Bu Et 2-OMeF H 3313 Bu Et 2-OMeF SnMe.sub.3 3314 Bu Et 2-OMeF Br 3315 Bu Et 2-OMeF I 3316 Bu Et 2-OCF.sub.3 H 3317 Bu Et 2-OCF.sub.3 SnMe.sub.3 3318 Bu Et 2-OCF.sub.3 Br 3319 Bu Et 2-OCF.sub.3 I 3320 Bu Et 2-OEtF H 3321 Bu Et 2-OEtF SnMe.sub.3 3322 Bu Et 2-OEtF Br 3323 Bu Et 2-OEtF I 3324 Bu Et 2-OPrF H 3325 Bu Et 2-OPrF SnMe.sub.3 3326 Bu Et 2-OPrF Br 3327 Bu Et 2-OPrF I 3328 Bu Et 2-CF.sub.3 H 3329 Bu Et 2-CF.sub.3 SnMe.sub.3 3330 Bu Et 2-CF.sub.3 Br 3331 Bu Et 2-CF.sub.3 I 3332 Bu Et 2-Br, 6-CF.sub.3 H 3333 Bu Et 2-Br, 6-CF.sub.3 SnMe.sub.3 3334 Bu Et 2-Br, 6-CF.sub.3 Br 3335 Bu Et 2-Br, 6-CF.sub.3 I 3336 Bu Et 2-Br, 6-Br H 3337 Bu Et 2-Br, 6-Br SnMe.sub.3 3338 Bu Et 2-Br, 6-Br Br 3339 Bu Et 2-Br, 6-Br I 3340 Pr Pr H H 3341 Pr Pr H SnMe.sub.3 3342 Pr Pr H Br 3343 Pr Pr H I 3344 Pr Pr 2-F H 3345 Pr Pr 2-F SnMe.sub.3 3346 Pr Pr 2-F Br 3347 Pr Pr 2-F I 3348 Pr Pr 2-Cl H 3349 Pr Pr 2-Cl SnMe.sub.3 3350 Pr Pr 2-Cl Br 3351 Pr Pr 2-Cl I 3352 Pr Pr 2-Br H 3353 Pr Pr 2-Br SnMe.sub.3 3354 Pr Pr 2-Br Br 3355 Pr Pr 2-Br I 3356 Pr Pr 2-Me H 3357 Pr Pr 2-Me SnMe.sub.3 3358 Pr Pr 2-Me Br 3359 Pr Pr 2-Me I 3360 Pr Pr 2-Et H 3361 Pr Pr 2-Et SnMe.sub.3 3362 Pr Pr 2-Et Br 3363 Pr Pr 2-Et I 3364 Pr Pr 2-Me, 6-Me H 3365 Pr Pr 2-Me, 6-Me SnMe.sub.3 3366 Pr Pr 2-Me, 6-Me Br 3367 Pr Pr 2-Me, 6-Me I 3368 Pr Pr 2-OH H 3369 Pr Pr 2-OH SnMe.sub.3 3370 Pr Pr 2-OH Br 3371 Pr Pr 2-OH I 3372 Pr Pr 2-OMe H 3373 Pr Pr 2-OMe SnMe.sub.3 3374 Pr Pr 2-OMe Br 3375 Pr Pr 2-OMe I 3376 Pr Pr 2-OMeF H 3377 Pr Pr 2-OMeF SnMe.sub.3 3378 Pr Pr 2-OMeF Br 3379 Pr Pr 2-OMeF I 3380 Pr Pr 2-OCF.sub.3 H 3381 Pr Pr 2-OCF.sub.3 SnMe.sub.3 3382 Pr Pr 2-OCF.sub.3 Br 3383 Pr Pr 2-OCF.sub.3 I 3384 Pr Pr 2-OEtF H 3385 Pr Pr 2-OEtF SnMe.sub.3 3386 Pr Pr 2-OEtF Br 3387 Pr Pr 2-OEtF I 3388 Pr Pr 2-OPrF H 3389 Pr Pr 2-OPrF SnMe.sub.3 3390 Pr Pr 2-OPrF Br 3391 Pr Pr 2-OPrF I 3392 Pr Pr 2-CF.sub.3 H 3393 Pr Pr 2-CF.sub.3 SnMe.sub.3 3394 Pr Pr 2-CF.sub.3 Br 3395 Pr Pr 2-CF.sub.3 I 3396 Pr Pr 2-Br, 6-CF.sub.3 H 3397 Pr Pr 2-Br, 6-CF.sub.3 SnMe.sub.3 3398 Pr Pr 2-Br, 6-CF.sub.3 Br 3399 Pr Pr 2-Br, 6-CF.sub.3 I 3400 Pr Pr 2-Br, 6-Br H 3401 Pr Pr 2-Br, 6-Br SnMe.sub.3 3402 Pr Pr 2-Br, 6-Br Br 3403 Pr Pr 2-Br, 6-Br I 3404 Pr Pr-F H H 3405 Pr Pr-F H SnMe.sub.3 3406 Pr Pr-F H Br 3407 Pr Pr-F H I 3408 Pr Pr-F 2-F H 3409 Pr Pr-F 2-F SnMe.sub.3 3410 Pr Pr-F 2-F Br 3411 Pr Pr-F 2-F I 3412 Pr Pr-F 2-Cl H 3413 Pr Pr-F 2-Cl SnMe.sub.3 3414 Pr Pr-F 2-Cl Br 3415 Pr Pr-F 2-Cl I 3416 Pr Pr-F 2-Br H 3417 Pr Pr-F 2-Br SnMe.sub.3 3418 Pr Pr-F 2-Br Br 3419 Pr Pr-F 2-Br I 3420 Pr Pr-F 2-Me H 3421 Pr Pr-F 2-Me SnMe.sub.3 3422 Pr Pr-F 2-Me Br 3423 Pr Pr-F 2-Me I 3424 Pr Pr-F 2-Et H 3425 Pr Pr-F 2-Et SnMe.sub.3 3426 Pr Pr-F 2-Et Br 3427 Pr Pr-F 2-Et I 3428 Pr Pr-F 2-Me, 6-Me H 3429 Pr Pr-F 2-Me, 6-Me SnMe.sub.3 3430 Pr Pr-F 2-Me, 6-Me Br 3431 Pr Pr-F 2-Me, 6-Me I 3432 Pr Pr-F 2-OH H 3433 Pr Pr-F 2-OH SnMe.sub.3 3434 Pr Pr-F 2-OH Br 3435 Pr Pr-F 2-OH I 3436 Pr Pr-F 2-OMe H 3437 Pr Pr-F 2-OMe SnMe.sub.3 3438 Pr Pr-F 2-OMe Br 3439 Pr Pr-F 2-OMe I 3440 Pr Pr-F 2-OMeF H 3441 Pr Pr-F 2-OMeF SnMe.sub.3 3442 Pr Pr-F 2-OMeF Br 3443 Pr Pr-F 2-OMeF I 3444 Pr Pr-F 2-OCF.sub.3 H 3445 Pr Pr-F 2-OCF.sub.3 SnMe.sub.3 3446 Pr Pr-F 2-OCF.sub.3 Br 3447 Pr Pr-F 2-OCF.sub.3 I 3448 Pr Pr-F 2-OEtF H 3449 Pr Pr-F 2-OEtF SnMe.sub.3 3450 Pr Pr-F 2-OEtF Br 3451 Pr Pr-F 2-OEtF I 3452 Pr Pr-F 2-OPrF H 3453 Pr Pr-F 2-OPrF SnMe.sub.3 3454 Pr Pr-F 2-OPrF Br 3455 Pr Pr-F 2-OPrF I 3456 Pr Pr-F 2-CF.sub.3 H 3457 Pr Pr-F 2-CF.sub.3 SnMe.sub.3 3458 Pr Pr-F 2-CF.sub.3 Br 3459 Pr Pr-F 2-CF.sub.3 I 3460 Pr Pr-F 2-Br, 6-CF.sub.3 H 3461 Pr Pr-F 2-Br, 6-CF.sub.3 SnMe.sub.3 3462 Pr Pr-F 2-Br, 6-CF.sub.3 Br 3463 Pr Pr-F 2-Br, 6-CF.sub.3 I 3464 Pr Pr-F 2-Br, 6-Br H 3465 Pr Pr-F 2-Br, 6-Br SnMe.sub.3 3466 Pr Pr-F 2-Br, 6-Br Br 3467 Pr Pr-F 2-Br, 6-Br I 3468 Pr Et-F H H 3469 Pr Et-F H SnMe.sub.3 3470 Pr Et-F H Br 3471 Pr Et-F H I 3472 Pr Et-F 2-F H 3473 Pr Et-F 2-F SnMe.sub.3 3474 Pr Et-F 2-F Br 3475 Pr Et-F 2-F I 3476 Pr Et-F 2-Cl H 3477 Pr Et-F 2-Cl SnMe.sub.3 3478 Pr Et-F 2-Cl Br 3479 Pr Et-F 2-Cl I 3480 Pr Et-F 2-Br H 3481 Pr Et-F 2-Br SnMe.sub.3 3482 Pr Et-F 2-Br Br 3483 Pr Et-F 2-Br I 3484 Pr Et-F 2-Me H 3485 Pr Et-F 2-Me SnMe.sub.3 3486 Pr Et-F 2-Me Br 3487 Pr Et-F 2-Me I 3488 Pr Et-F 2-Et H 3489 Pr Et-F 2-Et SnMe.sub.3 3490 Pr Et-F 2-Et Br 3491 Pr Et-F 2-Et I 3492 Pr Et-F 2-Me, 6-Me H 3493 Pr Et-F 2-Me, 6-Me SnMe.sub.3 3494 Pr Et-F 2-Me, 6-Me Br 3495 Pr Et-F 2-Me, 6-Me I 3496 Pr Et-F 2-OH H 3497 Pr Et-F 2-OH SnMe.sub.3 3498 Pr Et-F 2-OH Br 3499 Pr Et-F 2-OH I 3500 Pr Et-F 2-OMe H 3501 Pr Et-F 2-OMe SnMe.sub.3 3502 Pr Et-F 2-OMe Br 3503 Pr Et-F 2-OMe I 3504 Pr Et-F 2-OMeF H 3505 Pr Et-F 2-OMeF SnMe.sub.3 3506 Pr Et-F 2-OMeF Br 3507 Pr Et-F 2-OMeF I 3508 Pr Et-F 2-OCF.sub.3 H 3509 Pr Et-F 2-OCF.sub.3 SnMe.sub.3 3510 Pr Et-F 2-OCF.sub.3 Br 3511 Pr Et-F 2-OCF.sub.3 I 3512 Pr Et-F 2-OEtF H 3513 Pr Et-F 2-OEtF SnMe.sub.3 3514 Pr Et-F 2-OEtF Br 3515 Pr Et-F 2-OEtF I 3516 Pr Et-F 2-OPrF H 3517 Pr Et-F 2-OPrF SnMe.sub.3

3518 Pr Et-F 2-OPrF Br 3519 Pr Et-F 2-OPrF I 3520 Pr Et-F 2-CF.sub.3 H 3521 Pr Et-F 2-CF.sub.3 SnMe.sub.3 3522 Pr Et-F 2-CF.sub.3 Br 3523 Pr Et-F 2-CF.sub.3 I 3524 Pr Et-F 2-Br, 6-CF.sub.3 H 3525 Pr Et-F 2-Br, 6-CF.sub.3 SnMe.sub.3 3526 Pr Et-F 2-Br, 6-CF.sub.3 Br 3527 Pr Et-F 2-Br, 6-CF.sub.3 I 3528 Pr Et-F 2-Br, 6-Br H 3529 Pr Et-F 2-Br, 6-Br SnMe.sub.3 3530 Pr Et-F 2-Br, 6-Br Br 3531 Pr Et-F 2-Br, 6-Br I 3532 Pr-F Et H H 3533 Pr-F Et H SnMe.sub.3 3534 Pr-F Et H Br 3535 Pr-F Et H I 3536 Pr-F Et 2-F H 3537 Pr-F Et 2-F SnMe.sub.3 3538 Pr-F Et 2-F Br 3539 Pr-F Et 2-F I 3540 Pr-F Et 2-Cl H 3541 Pr-F Et 2-Cl SnMe.sub.3 3542 Pr-F Et 2-Cl Br 3543 Pr-F Et 2-Cl I 3544 Pr-F Et 2-Br H 3545 Pr-F Et 2-Br SnMe.sub.3 3546 Pr-F Et 2-Br Br 3547 Pr-F Et 2-Br I 3548 Pr-F Et 2-Me H 3549 Pr-F Et 2-Me SnMe.sub.3 3550 Pr-F Et 2-Me Br 3551 Pr-F Et 2-Me I 3552 Pr-F Et 2-Et H 3553 Pr-F Et 2-Et SnMe.sub.3 3554 Pr-F Et 2-Et Br 3555 Pr-F Et 2-Et I 3556 Pr-F Et 2-Me, 6-Me H 3557 Pr-F Et 2-Me, 6-Me SnMe.sub.3 3558 Pr-F Et 2-Me, 6-Me Br 3559 Pr-F Et 2-Me, 6-Me I 3560 Pr-F Et 2-OH H 3561 Pr-F Et 2-OH SnMe.sub.3 3562 Pr-F Et 2-OH Br 3563 Pr-F Et 2-OH I 3564 Pr-F Et 2-OMe H 3565 Pr-F Et 2-OMe SnMe.sub.3 3566 Pr-F Et 2-OMe Br 3567 Pr-F Et 2-OMe I 3568 Pr-F Et 2-OMeF H 3569 Pr-F Et 2-OMeF SnMe.sub.3 3570 Pr-F Et 2-OMeF Br 3571 Pr-F Et 2-OMeF I 3572 Pr-F Et 2-OCF.sub.3 H 3573 Pr-F Et 2-OCF.sub.3 SnMe.sub.3 3574 Pr-F Et 2-OCF.sub.3 Br 3575 Pr-F Et 2-OCF.sub.3 I 3576 Pr-F Et 2-OEtF H 3577 Pr-F Et 2-OEtF SnMe.sub.3 3578 Pr-F Et 2-OEtF Br 3579 Pr-F Et 2-OEtF I 3580 Pr-F Et 2-OPrF H 3581 Pr-F Et 2-OPrF SnMe.sub.3 3582 Pr-F Et 2-OPrF Br 3583 Pr-F Et 2-OPrF I 3584 Pr-F Et 2-CF.sub.3 H 3585 Pr-F Et 2-CF.sub.3 SnMe.sub.3 3586 Pr-F Et 2-CF.sub.3 Br 3587 Pr-F Et 2-CF.sub.3 I 3588 Pr-F Et 2-Br, 6-CF.sub.3 H 3589 Pr-F Et 2-Br, 6-CF.sub.3 SnMe.sub.3 3590 Pr-F Et 2-Br, 6-CF.sub.3 Br 3591 Pr-F Et 2-Br, 6-CF.sub.3 I 3592 Pr-F Et 2-Br, 6-Br H 3593 Pr-F Et 2-Br, 6-Br SnMe.sub.3 3594 Pr-F Et 2-Br, 6-Br Br 3595 Pr-F Et 2-Br, 6-Br I 3596 Bu Et-F H H 3597 Bu Et-F H SnMe.sub.3 3598 Bu Et-F H Br 3599 Bu Et-F H I 3600 Bu Et-F 2-F H 3601 Bu Et-F 2-F SnMe.sub.3 3602 Bu Et-F 2-F Br 3603 Bu Et-F 2-F I 3604 Bu Et-F 2-Cl H 3605 Bu Et-F 2-Cl SnMe.sub.3 3606 Bu Et-F 2-Cl Br 3607 Bu Et-F 2-Cl I 3608 Bu Et-F 2-Br H 3609 Bu Et-F 2-Br SnMe.sub.3 3610 Bu Et-F 2-Br Br 3611 Bu Et-F 2-Br I 3612 Bu Et-F 2-Me H 3613 Bu Et-F 2-Me SnMe.sub.3 3614 Bu Et-F 2-Me Br 3615 Bu Et-F 2-Me I 3616 Bu Et-F 2-Et H 3617 Bu Et-F 2-Et SnMe.sub.3 3618 Bu Et-F 2-Et Br 3619 Bu Et-F 2-Et I 3620 Bu Et-F 2-Me, 6-Me H 3621 Bu Et-F 2-Me, 6-Me SnMe.sub.3 3622 Bu Et-F 2-Me, 6-Me Br 3623 Bu Et-F 2-Me, 6-Me I 3624 Bu Et-F 2-OH H 3625 Bu Et-F 2-OH SnMe.sub.3 3626 Bu Et-F 2-OH Br 3627 Bu Et-F 2-OH I 3628 Bu Et-F 2-OMe H 3629 Bu Et-F 2-OMe SnMe.sub.3 3630 Bu Et-F 2-OMe Br 3631 Bu Et-F 2-OMe I 3632 Bu Et-F 2-OMeF H 3633 Bu Et-F 2-OMeF SnMe.sub.3 3634 Bu Et-F 2-OMeF Br 3635 Bu Et-F 2-OMeF I 3636 Bu Et-F 2-OCF.sub.3 H 3637 Bu Et-F 2-OCF.sub.3 SnMe.sub.3 3638 Bu Et-F 2-OCF.sub.3 Br 3639 Bu Et-F 2-OCF.sub.3 I 3640 Bu Et-F 2-OEtF H 3641 Bu Et-F 2-OEtF SnMe.sub.3 3642 Bu Et-F 2-OEtF Br 3643 Bu Et-F 2-OEtF I 3644 Bu Et-F 2-OPrF H 3645 Bu Et-F 2-OPrF SnMe.sub.3 3646 Bu Et-F 2-OPrF Br 3647 Bu Et-F 2-OPrF I 3648 Bu Et-F 2-CF.sub.3 H 3649 Bu Et-F 2-CF.sub.3 SnMe.sub.3 3650 Bu Et-F 2-CF.sub.3 Br 3651 Bu Et-F 2-CF.sub.3 I 3652 Bu Et-F 2-Br, 6-CF.sub.3 H 3653 Bu Et-F 2-Br, 6-CF.sub.3 SnMe.sub.3 3654 Bu Et-F 2-Br, 6-CF.sub.3 Br 3655 Bu Et-F 2-Br, 6-CF.sub.3 I 3656 Bu Et-F 2-Br, 6-Br H 3657 Bu Et-F 2-Br, 6-Br SnMe.sub.3 3658 Bu Et-F 2-Br, 6-Br Br 3659 Bu Et-F 2-Br, 6-Br I 3660 Bu-F Et H H 3661 Bu-F Et H SnMe.sub.3 3662 Bu-F Et H Br 3663 Bu-F Et H I 3664 Bu-F Et 2-F H 3665 Bu-F Et 2-F SnMe.sub.3 3666 Bu-F Et 2-F Br 3667 Bu-F Et 2-F I 3668 Bu-F Et 2-Cl H 3669 Bu-F Et 2-Cl SnMe.sub.3 3670 Bu-F Et 2-Cl Br 3671 Bu-F Et 2-Cl I 3672 Bu-F Et 2-Br H 3673 Bu-F Et 2-Br SnMe.sub.3 3674 Bu-F Et 2-Br Br 3675 Bu-F Et 2-Br I 3676 Bu-F Et 2-Me H 3677 Bu-F Et 2-Me SnMe.sub.3 3678 Bu-F Et 2-Me Br 3679 Bu-F Et 2-Me I 3680 Bu-F Et 2-Et H 3681 Bu-F Et 2-Et SnMe.sub.3 3682 Bu-F Et 2-Et Br 3683 Bu-F Et 2-Et I 3684 Bu-F Et 2-Me, 6-Me H 3685 Bu-F Et 2-Me, 6-Me SnMe.sub.3 3686 Bu-F Et 2-Me, 6-Me Br 3687 Bu-F Et 2-Me, 6-Me I 3688 Bu-F Et 2-OH H 3689 Bu-F Et 2-OH SnMe.sub.3 3690 Bu-F Et 2-OH Br 3691 Bu-F Et 2-OH I 3692 Bu-F Et 2-OMe H 3693 Bu-F Et 2-OMe SnMe.sub.3 3694 Bu-F Et 2-OMe Br 3695 Bu-F Et 2-OMe I 3696 Bu-F Et 2-OMeF H 3697 Bu-F Et 2-OMeF SnMe.sub.3 3698 Bu-F Et 2-OMeF Br 3699 Bu-F Et 2-OMeF I 3700 Bu-F Et 2-OCF.sub.3 H 3701 Bu-F Et 2-OCF.sub.3 SnMe.sub.3 3702 Bu-F Et 2-OCF.sub.3 Br 3703 Bu-F Et 2-OCF.sub.3 I 3704 Bu-F Et 2-OEtF H 3705 Bu-F Et 2-OEtF SnMe.sub.3 3706 Bu-F Et 2-OEtF Br 3707 Bu-F Et 2-OEtF I 3708 Bu-F Et 2-OPrF H 3709 Bu-F Et 2-OPrF SnMe.sub.3 3710 Bu-F Et 2-OPrF Br 3711 Bu-F Et 2-OPrF I 3712 Bu-F Et 2-CF.sub.3 H 3713 Bu-F Et 2-CF.sub.3 SnMe.sub.3 3714 Bu-F Et 2-CF.sub.3 Br 3715 Bu-F Et 2-CF.sub.3 I 3716 Bu-F Et 2-Br, 6-CF.sub.3 H 3717 Bu-F Et 2-Br, 6-CF.sub.3 SnMe.sub.3 3718 Bu-F Et 2-Br, 6-CF.sub.3 Br 3719 Bu-F Et 2-Br, 6-CF.sub.3 I 3720 Bu-F Et 2-Br, 6-Br H 3721 Bu-F Et 2-Br, 6-Br SnMe.sub.3 3722 Bu-F Et 2-Br, 6-Br Br 3723 Bu-F Et 2-Br, 6-Br I 3724 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H H 3725 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H SnMe.sub.3 3726 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H Br 3727 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H I 3728 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F H 3729 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F SnMe.sub.3 3730 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F Br 3731 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F I 3732 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl H 3733 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl SnMe.sub.3 3734 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl Br 3735 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl I 3736 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br H 3737 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br SnMe.sub.3 3738 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br Br 3739 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br I 3740 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me H 3741 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me SnMe.sub.3 3742 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me Br 3743 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me I 3744 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et H 3745 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et SnMe.sub.3 3746 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et Br 3747 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et I 3748 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Me H 3749 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Me SnMe.sub.3 3750 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Me Br 3751 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Me I 3752 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH H 3753 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH SnMe.sub.3 3754 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH Br 3755 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH I 3756 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe H 3757 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe SnMe.sub.3 3758 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe Br 3759 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe I 3760 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF H 3761 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF SnMe.sub.3 3762 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF Br 3763 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF I 3764 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 H 3765 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 SnMe.sub.3 3766 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 Br 3767 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 I 3768 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF H

3769 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF SnMe.sub.3 3770 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF Br 3771 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF I 3772 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF H 3773 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF SnMe.sub.3 3774 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF Br 3775 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF I 3776 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 H 3777 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 SnMe.sub.3 3778 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 Br 3779 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 I 3780 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-CF.sub.3 H 3781 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-CF.sub.3 SnMe.sub.3 3782 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-CF.sub.3 Br 3783 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-CF.sub.3 I 3784 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Br H 3785 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Br SnMe.sub.3 3786 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Br Br 3787 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Br I 3788 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H H 3789 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H SnMe.sub.3 3790 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H Br 3791 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H I 3792 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F H 3793 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F SnMe.sub.3 3794 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F Br 3795 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F I 3796 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl H 3797 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl SnMe.sub.3 3798 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl Br 3799 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl I 3800 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br H 3801 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br SnMe.sub.3 3802 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br Br 3803 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br I 3804 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me H 3805 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me SnMe.sub.3 3806 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me Br 3807 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me I 3808 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et H 3809 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et SnMe.sub.3 3810 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et Br 3811 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et I 3812 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Me H 3813 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Me SnMe.sub.3 3814 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Me Br 3815 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Me I 3816 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH H 3817 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH SnMe.sub.3 3818 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH Br 3819 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH I 3820 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe H 3821 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe SnMe.sub.3 3822 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe Br 3823 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe I 3824 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF H 3825 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF SnMe.sub.3 3826 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF Br 3827 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF I 3828 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 H 3829 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 SnMe.sub.3 3830 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 Br 3831 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 I 3832 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF H 3833 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF SnMe.sub.3 3834 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF Br 3835 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF I 3836 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF H 3837 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF SnMe.sub.3 3838 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF Br 3839 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF I 3840 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 H 3841 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 SnMe.sub.3 3842 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 Br 3843 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 I 3844 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-CF.sub.3 H 3845 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-CF.sub.3 SnMe.sub.3 3846 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-CF.sub.3 Br 3847 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-CF.sub.3 I 3848 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Br H 3849 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Br SnMe.sub.3 3850 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Br Br 3851 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Br I 3852 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H H 3853 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H SnMe.sub.3 3854 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H Br 3855 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H I 3856 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F H 3857 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F SnMe.sub.3 3858 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F Br 3859 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F I 3860 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl H 3861 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl SnMe.sub.3 3862 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl Br 3863 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl I 3864 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br H 3865 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br SnMe.sub.3 3866 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br Br 3867 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br I 3868 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me H 3869 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me SnMe.sub.3 3870 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me Br 3871 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me I 3872 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et H 3873 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et SnMe.sub.3 3874 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et Br 3875 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et I 3876 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 6-Me H 3877 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 6-Me SnMe.sub.3 3878 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 6-Me Br 3879 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 6-Me I 3880 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH H 3881 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH SnMe.sub.3 3882 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH Br 3883 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH I 3884 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe H 3885 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe SnMe.sub.3 3886 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe Br 3887 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe I 3888 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF H 3889 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF SnMe.sub.3 3890 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF Br 3891 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF I 3892 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3 H 3893 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3 SnMe.sub.3 3894 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3 Br 3895 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3 I 3896 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF H 3897 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF SnMe.sub.3 3898 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF Br 3899 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF I 3900 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF H 3901 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF SnMe.sub.3 3902 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF Br 3903 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF I 3904 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3 H 3905 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3 SnMe.sub.3 3906 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3 Br 3907 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3 I 3908 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-CF.sub.3 H 3909 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-CF.sub.3 SnMe.sub.3 3910 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-CF.sub.3 Br 3911 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-CF.sub.3 I 3912 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Br H 3913 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Br SnMe.sub.3 3914 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Br Br 3915 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Br I

TABLE-US-00019 TABLE 4 Substituents list for compounds of general structure IX. IXa ##STR00090## IXb ##STR00091## Compound # R.sup.1 = R.sup.2 = R.sup.4 = n = 3916 Bu Et H 1 3917 Bu Et H 2 3918 Bu Et H 3 3919 Bu Et 4-F 1 3920 Bu Et 4-F 2 3921 Bu Et 4-F 3 3922 Bu Et 5-F 1 3923 Bu Et 5-F 2 3924 Bu Et 5-F 3 3925 Bu Et 4-Cl 1 3926 Bu Et 4-Cl 2 3927 Bu Et 4-Cl 3 3928 Bu Et 4-Br 1 3929 Bu Et 4-Br 2 3930 Bu Et 4-Br 3 3931 Bu Et 4-Me 1 3932 Bu Et 4-Me 2 3933 Bu Et 4-Me 3 3934 Bu Et 4-CF.sub.3 1 3935 Bu Et 4-CF.sub.3 2 3936 Bu Et 4-CF.sub.3 3 3937 Bu Et 4-OH 1 3938 Bu Et 4-OH 2 3939 Bu Et 4-OH 3 3940 Bu Et 4-OMe 1 3941 Bu Et 4-OMe 2 3942 Bu Et 4-OMe 3 3943 Bu Et 4-OMeF 1 3944 Bu Et 4-OMeF 2 3945 Bu Et 4-OMeF 3 3946 Bu Et 4-OCF.sub.3 1 3947 Bu Et 4-OCF.sub.3 2 3948 Bu Et 4-OCF.sub.3 3 3949 Bu Et 4-OEtF 1 3950 Bu Et 4-OEtF 2 3951 Bu Et 4-OEtF 3 3952 Bu Et 4-OPrF 1 3953 Bu Et 4-OPrF 2 3954 Bu Et 4-OPrF 3 3955 Bu Et 4-i-Pr 1 3956 Bu Et 4-i-Pr 2 3957 Bu Et 4-i-Pr 3 3958 Bu Et 2-Br, 4-CF.sub.3 1 3959 Bu Et 2-Br, 4-CF.sub.3 2 3960 Bu Et 2-Br, 4-CF.sub.3 3 3961 Bu Et 2-CF.sub.3, 4-Br 1 3962 Bu Et 2-CF.sub.3, 4-Br 2 3963 Bu Et 2-CF.sub.3, 4-Br 3 3964 Bu Et 2-Br, 4-Br 1 3965 Bu Et 2-Br, 4-Br 2 3966 Bu Et 2-Br, 4-Br 3 3967 Bu Et 2-Br, 4-Me 1 3968 Bu Et 2-Br, 4-Me 2 3969 Bu Et 2-Br, 4-Me 3 3970 Pr Pr H 1 3971 Pr Pr H 2 3972 Pr Pr H 3 3973 Pr Pr 4-F 1 3974 Pr Pr 4-F 2 3975 Pr Pr 4-F 3 3976 Pr Pr 5-F 1 3977 Pr Pr 5-F 2 3978 Pr Pr 5-F 3 3979 Pr Pr 4-Cl 1 3980 Pr Pr 4-Cl 2 3981 Pr Pr 4-Cl 3 3982 Pr Pr 4-Br 1 3983 Pr Pr 4-Br 2 3984 Pr Pr 4-Br 3 3985 Pr Pr 4-Me 1 3986 Pr Pr 4-Me 2 3987 Pr Pr 4-Me 3 3988 Pr Pr 4-CF.sub.3 1 3989 Pr Pr 4-CF.sub.3 2 3990 Pr Pr 4-CF.sub.3 3 3991 Pr Pr 4-OH 1 3992 Pr Pr 4-OH 2 3993 Pr Pr 4-OH 3 3994 Pr Pr 4-OMe 1 3995 Pr Pr 4-OMe 2 3996 Pr Pr 4-OMe 3 3997 Pr Pr 4-OMeF 1 3998 Pr Pr 4-OMeF 2 3999 Pr Pr 4-OMeF 3 4000 Pr Pr 4-OCF.sub.3 1 4001 Pr Pr 4-OCF.sub.3 2 4002 Pr Pr 4-OCF.sub.3 3 4003 Pr Pr 4-OEtF 1 4004 Pr Pr 4-OEtF 2 4005 Pr Pr 4-OEtF 3 4006 Pr Pr 4-OPrF 1 4007 Pr Pr 4-OPrF 2 4008 Pr Pr 4-OPrF 3 4009 Pr Pr 4-i-Pr 1 4010 Pr Pr 4-i-Pr 2 4011 Pr Pr 4-i-Pr 3 4012 Pr Pr 2-Br, 4-CF.sub.3 1 4013 Pr Pr 2-Br, 4-CF.sub.3 2 4014 Pr Pr 2-Br, 4-CF.sub.3 3 4015 Pr Pr 2-CF.sub.3, 4-Br 1 4016 Pr Pr 2-CF.sub.3, 4-Br 2 4017 Pr Pr 2-CF.sub.3, 4-Br 3 4018 Pr Pr 2-Br, 4-Br 1 4019 Pr Pr 2-Br, 4-Br 2 4020 Pr Pr 2-Br, 4-Br 3 4021 Pr Pr 2-Br, 4-Me 1 4022 Pr Pr 2-Br, 4-Me 2 4023 Pr Pr 2-Br, 4-Me 3 4024 Pr Pr-F H 1 4025 Pr Pr-F H 2 4026 Pr Pr-F H 3 4027 Pr Pr-F 4-F 1 4028 Pr Pr-F 4-F 2 4029 Pr Pr-F 4-F 3 4030 Pr Pr-F 5-F 1 4031 Pr Pr-F 5-F 2 4032 Pr Pr-F 5-F 3 4033 Pr Pr-F 4-Cl 1 4034 Pr Pr-F 4-Cl 2 4035 Pr Pr-F 4-Cl 3 4036 Pr Pr-F 4-Br 1 4037 Pr Pr-F 4-Br 2 4038 Pr Pr-F 4-Br 3 4039 Pr Pr-F 4-Me 1 4040 Pr Pr-F 4-Me 2 4041 Pr Pr-F 4-Me 3 4042 Pr Pr-F 4-CF.sub.3 1 4043 Pr Pr-F 4-CF.sub.3 2 4044 Pr Pr-F 4-CF.sub.3 3 4045 Pr Pr-F 4-OH 1 4046 Pr Pr-F 4-OH 2 4047 Pr Pr-F 4-OH 3 4048 Pr Pr-F 4-OMe 1 4049 Pr Pr-F 4-OMe 2 4050 Pr Pr-F 4-OMe 3 4051 Pr Pr-F 4-OMeF 1 4052 Pr Pr-F 4-OMeF 2 4053 Pr Pr-F 4-OMeF 3 4054 Pr Pr-F 4-OCF.sub.3 1 4055 Pr Pr-F 4-OCF.sub.3 2 4056 Pr Pr-F 4-OCF.sub.3 3 4057 Pr Pr-F 4-OEtF 1 4058 Pr Pr-F 4-OEtF 2 4059 Pr Pr-F 4-OEtF 3 4060 Pr Pr-F 4-OPrF 1 4061 Pr Pr-F 4-OPrF 2 4062 Pr Pr-F 4-OPrF 3 4063 Pr Pr-F 4-i-Pr 1 4064 Pr Pr-F 4-i-Pr 2 4065 Pr Pr-F 4-i-Pr 3 4066 Pr Pr-F 2-Br, 4-CF.sub.3 1 4067 Pr Pr-F 2-Br, 4-CF.sub.3 2 4068 Pr Pr-F 2-Br, 4-CF.sub.3 3 4069 Pr Pr-F 2-CF.sub.3, 4-Br 1 4070 Pr Pr-F 2-CF.sub.3, 4-Br 2 4071 Pr Pr-F 2-CF.sub.3, 4-Br 3 4072 Pr Pr-F 2-Br, 4-Br 1 4073 Pr Pr-F 2-Br, 4-Br 2 4074 Pr Pr-F 2-Br, 4-Br 3 4075 Pr Pr-F 2-Br, 4-Me 1 4076 Pr Pr-F 2-Br, 4-Me 2 4077 Pr Pr-F 2-Br, 4-Me 3 4078 Pr Et-F H 1 4079 Pr Et-F H 2 4080 Pr Et-F H 3 4081 Pr Et-F 4-F 1 4082 Pr Et-F 4-F 2 4083 Pr Et-F 4-F 3 4084 Pr Et-F 5-F 1 4085 Pr Et-F 5-F 2 4086 Pr Et-F 5-F 3 4087 Pr Et-F 4-Cl 1 4088 Pr Et-F 4-Cl 2 4089 Pr Et-F 4-Cl 3 4090 Pr Et-F 4-Br 1 4091 Pr Et-F 4-Br 2 4092 Pr Et-F 4-Br 3 4093 Pr Et-F 4-Me 1 4094 Pr Et-F 4-Me 2 4095 Pr Et-F 4-Me 3 4096 Pr Et-F 4-CF.sub.3 1 4097 Pr Et-F 4-CF.sub.3 2 4098 Pr Et-F 4-CF.sub.3 3 4099 Pr Et-F 4-OH 1 4100 Pr Et-F 4-OH 2 4101 Pr Et-F 4-OH 3 4102 Pr Et-F 4-OMe 1 4103 Pr Et-F 4-OMe 2 4104 Pr Et-F 4-OMe 3 4105 Pr Et-F 4-OMeF 1 4106 Pr Et-F 4-OMeF 2 4107 Pr Et-F 4-OMeF 3 4108 Pr Et-F 4-OCF.sub.3 1 4109 Pr Et-F 4-OCF.sub.3 2 4110 Pr Et-F 4-OCF.sub.3 3 4111 Pr Et-F 4-OEtF 1 4112 Pr Et-F 4-OEtF 2 4113 Pr Et-F 4-OEtF 3 4114 Pr Et-F 4-OPrF 1 4115 Pr Et-F 4-OPrF 2 4116 Pr Et-F 4-OPrF 3 4117 Pr Et-F 4-i-Pr 1 4118 Pr Et-F 4-i-Pr 2 4119 Pr Et-F 4-i-Pr 3 4120 Pr Et-F 2-Br, 4-CF.sub.3 1 4121 Pr Et-F 2-Br, 4-CF.sub.3 2 4122 Pr Et-F 2-Br, 4-CF.sub.3 3 4123 Pr Et-F 2-CF.sub.3, 4-Br 1 4124 Pr Et-F 2-CF.sub.3, 4-Br 2 4125 Pr Et-F 2-CF.sub.3, 4-Br 3 4126 Pr Et-F 2-Br, 4-Br 1 4127 Pr Et-F 2-Br, 4-Br 2 4128 Pr Et-F 2-Br, 4-Br 3 4129 Pr Et-F 2-Br, 4-Me 1 4130 Pr Et-F 2-Br, 4-Me 2 4131 Pr Et-F 2-Br, 4-Me 3 4132 Pr-F Et H 1 4133 Pr-F Et H 2 4134 Pr-F Et H 3 4135 Pr-F Et 4-F 1 4136 Pr-F Et 4-F 2 4137 Pr-F Et 4-F 3 4138 Pr-F Et 5-F 1 4139 Pr-F Et 5-F 2 4140 Pr-F Et 5-F 3 4141 Pr-F Et 4-Cl 1 4142 Pr-F Et 4-Cl 2 4143 Pr-F Et 4-Cl 3 4144 Pr-F Et 4-Br 1 4145 Pr-F Et 4-Br 2 4146 Pr-F Et 4-Br 3 4147 Pr-F Et 4-Me 1 4148 Pr-F Et 4-Me 2 4149 Pr-F Et 4-Me 3 4150 Pr-F Et 4-CF.sub.3 1 4151 Pr-F Et 4-CF.sub.3 2 4152 Pr-F Et 4-CF.sub.3 3 4153 Pr-F Et 4-OH 1 4154 Pr-F Et 4-OH 2

4155 Pr-F Et 4-OH 3 4156 Pr-F Et 4-OMe 1 4157 Pr-F Et 4-OMe 2 4158 Pr-F Et 4-OMe 3 4159 Pr-F Et 4-OMeF 1 4160 Pr-F Et 4-OMeF 2 4161 Pr-F Et 4-OMeF 3 4162 Pr-F Et 4-OCF.sub.3 1 4163 Pr-F Et 4-OCF.sub.3 2 4164 Pr-F Et 4-OCF.sub.3 3 4165 Pr-F Et 4-OEtF 1 4166 Pr-F Et 4-OEtF 2 4167 Pr-F Et 4-OEtF 3 4168 Pr-F Et 4-OPrF 1 4169 Pr-F Et 4-OPrF 2 4170 Pr-F Et 4-OPrF 3 4171 Pr-F Et 4-i-Pr 1 4172 Pr-F Et 4-i-Pr 2 4173 Pr-F Et 4-i-Pr 3 4174 Pr-F Et 2-Br, 4-CF.sub.3 1 4175 Pr-F Et 2-Br, 4-CF.sub.3 2 4176 Pr-F Et 2-Br, 4-CF.sub.3 3 4177 Pr-F Et 2-CF.sub.3, 4-Br 1 4178 Pr-F Et 2-CF.sub.3, 4-Br 2 4179 Pr-F Et 2-CF.sub.3, 4-Br 3 4180 Pr-F Et 2-Br, 4-Br 1 4181 Pr-F Et 2-Br, 4-Br 2 4182 Pr-F Et 2-Br, 4-Br 3 4183 Pr-F Et 2-Br, 4-Me 1 4184 Pr-F Et 2-Br, 4-Me 2 4185 Pr-F Et 2-Br, 4-Me 3 4186 Bu Et-F H 1 4187 Bu Et-F H 2 4188 Bu Et-F H 3 4189 Bu Et-F 4-F 1 4190 Bu Et-F 4-F 2 4191 Bu Et-F 4-F 3 4192 Bu Et-F 5-F 1 4193 Bu Et-F 5-F 2 4194 Bu Et-F 5-F 3 4195 Bu Et-F 4-Cl 1 4196 Bu Et-F 4-Cl 2 4197 Bu Et-F 4-Cl 3 4198 Bu Et-F 4-Br 1 4199 Bu Et-F 4-Br 2 4200 Bu Et-F 4-Br 3 4201 Bu Et-F 4-Me 1 4202 Bu Et-F 4-Me 2 4203 Bu Et-F 4-Me 3 4204 Bu Et-F 4-CF.sub.3 1 4205 Bu Et-F 4-CF.sub.3 2 4206 Bu Et-F 4-CF.sub.3 3 4207 Bu Et-F 4-OH 1 4208 Bu Et-F 4-OH 2 4209 Bu Et-F 4-OH 3 4210 Bu Et-F 4-OMe 1 4211 Bu Et-F 4-OMe 2 4212 Bu Et-F 4-OMe 3 4213 Bu Et-F 4-OMeF 1 4214 Bu Et-F 4-OMeF 2 4215 Bu Et-F 4-OMeF 3 4216 Bu Et-F 4-OCF.sub.3 1 4217 Bu Et-F 4-OCF.sub.3 2 4218 Bu Et-F 4-OCF.sub.3 3 4219 Bu Et-F 4-OEtF 1 4220 Bu Et-F 4-OEtF 2 4221 Bu Et-F 4-OEtF 3 4222 Bu Et-F 4-OPrF 1 4223 Bu Et-F 4-OPrF 2 4224 Bu Et-F 4-OPrF 3 4225 Bu Et-F 4-i-Pr 1 4226 Bu Et-F 4-i-Pr 2 4227 Bu Et-F 4-i-Pr 3 4228 Bu Et-F 2-Br, 4-CF.sub.3 1 4229 Bu Et-F 2-Br, 4-CF.sub.3 2 4230 Bu Et-F 2-Br, 4-CF.sub.3 3 4231 Bu Et-F 2-CF.sub.3, 4-Br 1 4232 Bu Et-F 2-CF.sub.3, 4-Br 2 4233 Bu Et-F 2-CF.sub.3, 4-Br 3 4234 Bu Et-F 2-Br, 4-Br 1 4235 Bu Et-F 2-Br, 4-Br 2 4236 Bu Et-F 2-Br, 4-Br 3 4237 Bu Et-F 2-Br, 4-Me 1 4238 Bu Et-F 2-Br, 4-Me 2 4239 Bu Et-F 2-Br, 4-Me 3 4240 Bu-F Et H 1 4241 Bu-F Et H 2 4242 Bu-F Et H 3 4243 Bu-F Et 4-F 1 4244 Bu-F Et 4-F 2 4245 Bu-F Et 4-F 3 4246 Bu-F Et 5-F 1 4247 Bu-F Et 5-F 2 4248 Bu-F Et 5-F 3 4249 Bu-F Et 4-Cl 1 4250 Bu-F Et 4-Cl 2 4251 Bu-F Et 4-Cl 3 4252 Bu-F Et 4-Br 1 4253 Bu-F Et 4-Br 2 4254 Bu-F Et 4-Br 3 4255 Bu-F Et 4-Me 1 4256 Bu-F Et 4-Me 2 4257 Bu-F Et 4-Me 3 4258 Bu-F Et 4-CF.sub.3 1 4259 Bu-F Et 4-CF.sub.3 2 4260 Bu-F Et 4-CF.sub.3 3 4261 Bu-F Et 4-OH 1 4262 Bu-F Et 4-OH 2 4263 Bu-F Et 4-OH 3 4264 Bu-F Et 4-OMe 1 4265 Bu-F Et 4-OMe 2 4266 Bu-F Et 4-OMe 3 4267 Bu-F Et 4-OMeF 1 4268 Bu-F Et 4-OMeF 2 4269 Bu-F Et 4-OMeF 3 4270 Bu-F Et 4-OCF.sub.3 1 4271 Bu-F Et 4-OCF.sub.3 2 4272 Bu-F Et 4-OCF.sub.3 3 4273 Bu-F Et 4-OEtF 1 4274 Bu-F Et 4-OEtF 2 4275 Bu-F Et 4-OEtF 3 4276 Bu-F Et 4-OPrF 1 4277 Bu-F Et 4-OPrF 2 4278 Bu-F Et 4-OPrF 3 4279 Bu-F Et 4-i-Pr 1 4280 Bu-F Et 4-i-Pr 2 4281 Bu-F Et 4-i-Pr 3 4282 Bu-F Et 2-Br, 4-CF.sub.3 1 4283 Bu-F Et 2-Br, 4-CF.sub.3 2 4284 Bu-F Et 2-Br, 4-CF.sub.3 3 4285 Bu-F Et 2-CF.sub.3, 4-Br 1 4286 Bu-F Et 2-CF.sub.3, 4-Br 2 4287 Bu-F Et 2-CF.sub.3, 4-Br 3 4288 Bu-F Et 2-Br, 4-Br 1 4289 Bu-F Et 2-Br, 4-Br 2 4290 Bu-F Et 2-Br, 4-Br 3 4291 Bu-F Et 2-Br, 4-Me 1 4292 Bu-F Et 2-Br, 4-Me 2 4293 Bu-F Et 2-Br, 4-Me 3 4294 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H 1 4295 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H 2 4296 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H 3 4297 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F 1 4298 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F 2 4299 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F 3 4300 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F 1 4301 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F 2 4302 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F 3 4303 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl 1 4304 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl 2 4305 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl 3 4306 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br 1 4307 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br 2 4308 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br 3 4309 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me 1 4310 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me 2 4311 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me 3 4312 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 1 4313 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 2 4314 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 3 4315 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH 1 4316 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH 2 4317 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH 3 4318 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe 1 4319 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe 2 4320 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe 3 4321 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF 1 4322 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF 2 4323 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF 3 4324 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 1 4325 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 2 4326 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 3 4327 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF 1 4328 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF 2 4329 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF 3 4330 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF 1 4331 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF 2 4332 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF 3 4333 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr 1 4334 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr 2 4335 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr 3 4336 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 1 4337 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 2 4338 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 3 4339 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br 1 4340 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br 2 4341 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br 3 4342 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br 1 4343 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br 2 4344 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br 3 4345 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me 1 4346 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me 2 4347 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me 3 4348 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H 1 4349 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H 2 4350 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H 3 4351 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F 1 4352 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F 2 4353 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F 3 4354 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F 1 4355 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F 2 4356 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F 3 4357 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl 1 4358 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl 2 4359 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl 3 4360 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br 1 4361 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br 2 4362 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br 3 4363 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me 1 4364 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me 2 4365 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me 3 4366 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 1 4367 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 2 4368 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 3 4369 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH 1 4370 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH 2 4371 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH 3 4372 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe 1 4373 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe 2 4374 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe 3 4375 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF 1 4376 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF 2 4377 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF 3 4378 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 1 4379 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 2 4380 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 3 4381 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF 1 4382 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF 2 4383 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF 3 4384 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF 1 4385 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF 2 4386 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF 3 4387 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr 1 4388 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr 2 4389 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr 3 4390 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 1 4391 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 2 4392 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 3 4393 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br 1 4394 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br 2 4395 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br 3 4396 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br 1 4397 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br 2 4398 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br 3 4399 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me 1 4400 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me 2 4401 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me 3 4402 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H 1 4403 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H 2 4404 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H 3 4405 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F 1

4406 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F 2 4407 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-F 3 4408 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F 1 4409 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F 2 4410 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 5-F 3 4411 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl 1 4412 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl 2 4413 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Cl 3 4414 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br 1 4415 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br 2 4416 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br 3 4417 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me 1 4418 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me 2 4419 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me 3 4420 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 1 4421 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 2 4422 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-CF.sub.3 3 4423 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH 1 4424 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH 2 4425 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH 3 4426 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe 1 4427 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe 2 4428 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe 3 4429 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF 1 4430 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF 2 4431 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF 3 4432 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 1 4433 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 2 4434 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 3 4435 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF 1 4436 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF 2 4437 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF 3 4438 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF 1 4439 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF 2 4440 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF 3 4441 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr 1 4442 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr 2 4443 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-i-Pr 3 4444 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 1 4445 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 2 4446 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 3 4447 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br 1 4448 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br 2 4449 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br 3 4450 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br 1 4451 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br 2 4452 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br 3 4453 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me 1 4454 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me 2 4455 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me 3

TABLE-US-00020 TABLE 5 Substituent list for compounds of general structure X. X ##STR00092## Compound # R.sup.1 = R.sup.2 = R.sup.3 = 4456 Bu Et H 4457 Bu Et 2-t-Bu 4458 Bu Et 2-Br 4459 Bu Et 3-Br 4460 Bu Et 4-Br 4461 Bu Et 2-I 4462 Bu Et 3-I 4463 Bu Et 4-I 4464 Bu Et 2-SnMe.sub.3 4465 Bu Et 3-SnMe.sub.3 4466 Bu Et 4-SnMe.sub.3 4467 Bu Et 2-Me 4468 Bu Et 3-Me 4469 Bu Et 4-Me 4470 Bu Et 2-OH 4471 Bu Et 3-OH 4472 Bu Et 4-OH 4473 Bu Et 2-OMe 4474 Bu Et 3-OMe 4475 Bu Et 4-OMe 4476 Bu Et 2-OMeF 4477 Bu Et 3-OMeF 4478 Bu Et 4-OMeF 4479 Bu Et 2-OCF.sub.3 4480 Bu Et 3-OCF.sub.3 4481 Bu Et 4-OCF.sub.3 4482 Bu Et 2-OEtF 4483 Bu Et 3-OEtF 4484 Bu Et 4-OEtF 4485 Bu Et 2-OPrF 4486 Bu Et 3-OPrF 4487 Bu Et 4-OPrF 4488 Bu Et 2-SH 4489 Bu Et 3-SH 4490 Bu Et 4-SH 4491 Bu Et 2-SMe 4492 Bu Et 3-SMe 4493 Bu Et 4-SMe 4494 Bu Et 2-SMeF 4495 Bu Et 3-SMeF 4496 Bu Et 4-SMeF 4497 Bu Et 2-SCF.sub.3 4498 Bu Et 3-SCF.sub.3 4499 Bu Et 4-SCF.sub.3 4500 Bu Et 2-SEtF 4501 Bu Et 3-SEtF 4502 Bu Et 4-SEtF 4503 Bu Et 2-SPrF 4504 Bu Et 3-SPrF 4505 Bu Et 4-SPrF 4506 Bu Et 2-OMe, 4-OMe 4507 Bu Et 2-Me, 5-OH 4508 Bu Et 2-Me, 5-OMe 4509 Bu Et 2-Me, 5-OMeF 4510 Bu Et 2-Me, 5-OEtF 4511 Bu Et 2-Me, 5-OPrF 4512 Bu Et 2-Me, 4-OH 4513 Bu Et 2-Me, 4-OMe 4514 Bu Et 2-Me, 4-OMeF 4515 Bu Et 2-Me, 4-OCF.sub.3 4516 Bu Et 2-Me, 4-OEtF 4517 Bu Et 2-Me, 4-OPrF 4518 Bu Et 2-OH, 4-Me 4519 Bu Et 2-OMe, 4-Me 4520 Bu Et 2-OMeF, 4-Me 4521 Bu Et 2-OCF.sub.3, 4-Me 4522 Bu Et 2-OEtF, 4-Me 4523 Bu Et 2-OPrF, 4-Me 4524 Bu Et 2-Cl, 4-OH 4525 Bu Et 2-Cl, 4-OMe 4526 Bu Et 2-Cl, 4-OMeF 4527 Bu Et 2-Cl, 4-OCF.sub.3 4528 Bu Et 2-Cl, 4-OEtF 4529 Bu Et 2-Cl, 4-OPrF 4530 Bu Et 2-F, 4-F 4531 Bu Et 2-Cl, 4-Cl 4532 Bu Et 2-Cl, 4-F 4533 Bu Et 2-Cl, 4-NO.sub.2 4534 Bu Et 2-Cl, 4-NH.sub.2 4535 Bu Et 2-Cl, 4-NHMe 4536 Bu Et 2-Cl, 4-NMe.sub.2 4537 Bu Et 2-Cl, 4-NMe.sub.3OTf 4538 Bu Et 2-Cl, 4-NMe.sub.3I 4539 Bu Et 2-Cl, 5-F 4540 Bu Et 2-Cl, 5-NO.sub.2 4541 Bu Et 2-Cl, 5-NH.sub.2 4542 Bu Et 2-Cl, 5-NHMe 4543 Bu Et 2-Cl, 5-NMe.sub.2 4544 Bu Et 2-Cl, 5-NMe.sub.3OTf 4545 Bu Et 2-Cl, 5-NMe.sub.3I 4546 Bu Et 2-F, 4-Cl 4547 Bu Et 2-NO.sub.2, 4-Cl 4548 Bu Et 2-NH.sub.2, 4-Cl 4549 Bu Et 2-NHMe, 4-Cl 4550 Bu Et 2-NMe.sub.2, 4-Cl 4551 Bu Et 2-NMe.sub.3OTf, 4-Cl 4552 Bu Et 2-NMe.sub.3I, 4-Cl 4553 Bu Et 2-F, 5-Cl 4554 Bu Et 2-NO.sub.2, 5-Cl 4555 Bu Et 2-NH.sub.2, 5-Cl 4556 Bu Et 2-NHMe, 5-Cl 4557 Bu Et 2-NMe.sub.2, 5-Cl 4558 Bu Et 2-NMe.sub.3OTF, 5-Cl 4559 Bu Et 2-NMe.sub.3I, 5-Cl 4560 Bu Et 2-Br, 4-F 4561 Bu Et 2-Br, 4-NO.sub.2 4562 Bu Et 2-Br, 4-NH.sub.2 4563 Bu Et 2-Br, 4-NHMe 4564 Bu Et 2-Br, 4-NMe.sub.2 4565 Bu Et 2-Br, 4-NMe.sub.3OTf 4566 Bu Et 2-Br, 4-NMe.sub.3I 4567 Bu Et 2-Br, 5-F 4568 Bu Et 2-Br, 5-NO.sub.2 4569 Bu Et 2-Br, 5-NH.sub.2 4570 Bu Et 2-Br, 5-NHMe 4571 Bu Et 2-Br, 5-NMe.sub.3 4572 Bu Et 2-Br, 5-NMe.sub.3OTf 4573 Bu Et 2-Br, 5-NMe.sub.3I 4574 Bu Et 2-F, 4-Br 4575 Bu Et 2-NO.sub.2, 4-Br 4576 Bu Et 2-NH.sub.2, 4-Br 4577 Bu Et 2-NHMe, 4-Br 4578 Bu Et 2-NMe.sub.3, 4-Br 4579 Bu Et 2-NMe.sub.3OTf, 4-Br 4580 Bu Et 2-NMe.sub.3I, 4-Br 4581 Bu Et 2-I, 4-F 4582 Bu Et 2-I, 4-NO.sub.2 4583 Bu Et 2-I, 4-NH.sub.2 4584 Bu Et 2-I, 4-NHMe 4585 Bu Et 2-I, 4-NMe.sub.2 4586 Bu Et 2-I, 4-NMe.sub.3OTf 4587 Bu Et 2-I, 4-NMe.sub.3I 4588 Bu Et 2-F, 4-I 4589 Bu Et 2-NO.sub.2, 4-I 4590 Bu Et 2-NH.sub.2, 4-I 4591 Bu Et 2-NHMe, 4-I 4592 Bu Et 2-NMe.sub.2, 4-I 4593 Bu Et 2-NMe.sub.3OTf, 4-I 4594 Bu Et 2-NMe.sub.3I, 4-I 4595 Bu Et 2-Me, 3-F 4596 Bu Et 2-Me, 3-NO.sub.2 4597 Bu Et 2-Me, 3-NH.sub.2 4598 Bu Et 2-Me, 3-NHMe 4599 Bu Et 2-Me, 3-NMe.sub.2 4600 Bu Et 2-Me, 3-NMe.sub.3OTf 4601 Bu Et 2-Me, 3-NMe.sub.3I 4602 Bu Et 2-Me, 4-F 4603 Bu Et 2-Me, 4-NO.sub.2 4604 Bu Et 2-Me, 4-NH.sub.2 4605 Bu Et 2-Me, 4-NHMe 4606 Bu Et 2-Me, 4-NMe.sub.2 4607 Bu Et 2-Me, 4-NMe.sub.3OTf 4608 Bu Et 2-Me, 4-NMe.sub.3I 4609 Bu Et 2-Me, 5-F 4610 Bu Et 2-Me, 5-NO.sub.2 4611 Bu Et 2-Me, 5-NH.sub.2 4612 Bu Et 2-Me, 5-NHMe 4613 Bu Et 2-Me, 5-NMe.sub.2 4614 Bu Et 2-Me, 5-NMe.sub.3OTf 4615 Bu Et 2-Me, 5-NMe.sub.3I 4616 Bu Et 2-F, 4-Me 4617 Bu Et 2-NO.sub.2, 4-Me 4618 Bu Et 2-NH.sub.2, 4-Me 4619 Bu Et 2-NHMe, 4-Me 4620 Bu Et 2-NMe.sub.2, 4-Me 4621 Bu Et 2-NMe.sub.3, 4-Me 4622 Bu Et 2-NMe.sub.3OTf, 4-Me 4623 Bu Et 2-NMe.sub.3I, 4-Me 4624 Bu Et 2-SnMe.sub.3, 4-F 4625 Bu Et 2-SnMe.sub.3, 5-F 4626 Bu Et 2-F, 4-SnMe.sub.3 4627 Bu Et 2-Br, 6-Cl, 4-F 4628 Bu Et 2-Br, 6-Cl, 4-NO.sub.2 4629 Bu Et 2-Br, 6-Cl, 4-NH.sub.2 4630 Bu Et 2-Br, 6-Cl, 4-NHMe 4631 Bu Et 2-Br, 6-Cl, 4-NMe.sub.2 4632 Bu Et 2-Br, 6-Cl, 4-NMe.sub.3OTf 4633 Bu Et 2-Br, 6-Cl, 4-NMe.sub.3I 4634 Bu Et 2-Me, 6-Cl, 4-F 4635 Bu Et 2-SnMe.sub.3, 6-Cl, 4-F 4636 Bu Et 2-Cl, 4-Me 4637 Bu Et 2-Cl, 4-Br 4638 Bu Et 2-Cl, 4-SnMe.sub.3 4639 Bu Et 2-Br, 4-Cl 4640 Bu Et 2-SnMe.sub.3, 4-Cl 4641 Bu Et 2-Me, 4-Cl 4642 Bu Et 2-Br, 4-Br 4643 Bu Et 2-Br, 4-Me 4644 Bu Et 2-Br, 4-SnMe.sub.3 4645 Bu Et 2-SnMe.sub.3, 4-Br 4646 Bu Et 2-Me, 4-Br 4647 Bu Et 2-Me, 4-SnMe.sub.3 4648 Bu Et 2-SnMe.sub.3, 4-Me 4649 Bu Et 2-Me, 4-Me 4650 Bu Et 2-Et, 4-Br 4651 Bu Et 2-Et, 4-SnMe.sub.3 4652 Bu Et 2-Et, 4-Me 4653 Bu Et 2-Me, 4-Me, 6-Me 4654 Bu Et 2-Me, 4-Br, 6-Me 4655 Bu Et 2-Me, 4-SnMe.sub.3, 6-Me 4656 Bu Et 2-Et, 6-Me 4657 Bu Et 2-Br, 4-i-Pr 4658 Bu Et 2-SnMe.sub.3, 4-i-Pr 4659 Bu Et 2-Me, 4-i-Pr 4660 Bu Et 2-Br, 4-Br, 6-Br 4661 Bu Et 2-Br, 4-Me, 6-Br 4662 Bu Et 2-Br, 4-SnMe.sub.3, 6-Br 4663 Bu Et 2-SnMe.sub.3, 4-Br, 6-Br 4664 Bu Et 2-Br, 4-Br, 6-Me 4665 Bu Et 2-Br, 4-CF.sub.3, 6-Br 4666 Bu Et 2-Br, 4-Br, 6-CF.sub.3 4667 Bu Et 2-CF.sub.3, 4-CF.sub.3 4668 Bu Et 2-Cl, 4-CF.sub.3 4669 Bu Et 2-CF.sub.3, 4-Cl 4670 Bu Et 2-Br, 4-CF.sub.3 4671 Bu Et 2-SnMe.sub.3, 4-CF.sub.3 4672 Bu Et 2-Me, 4-CF.sub.3 4673 Bu Et 2-CF.sub.3, 4-Br 4674 Bu Et 2-CF.sub.3, 4-SnMe.sub.3 4675 Bu Et 2-CF.sub.3, 4-Me 4676 Bu Et 2-Br, 4-OH 4677 Bu Et 2-Br, 4-OMe 4678 Bu Et 2-Br, 4-OMeF 4679 Bu Et 2-Br, 4-OCF.sub.3 4680 Bu Et 2-Br, 4-OEtF 4681 Bu Et 2-Br, 4-OPrF 4682 Bu Et 2-OH, 4-Br 4683 Bu Et 2-OMe, 4-Br 4684 Bu Et 2-OMeF, 4-Br 4685 Bu Et 2-OCF.sub.3, 4-Br 4686 Bu Et 2-OEtF, 4-Br 4687 Bu Et 2-OPrF, 4-Br 4688 Bu Et 2-I, 4-OH 4689 Bu Et 2-I, 4-OMe 4690 Bu Et 2-I, 4-OMeF 4691 Bu Et 2-I, 4-OCF.sub.3 4692 Bu Et 2-I, 4-OEtF 4693 Bu Et 2-I, 4-OPrF 4694 Bu Et 2-OH, 4-I 4695 Bu Et 2-OMe, 4-I 4696 Bu Et 2-OMeF, 4-I 4697 Bu Et 2-OCF.sub.3, 4-I

4698 Bu Et 2-OEtF, 4-I 4699 Bu Et 2-OPrF, 4-I 4700 Bu Et 2-SnMe.sub.3, 4-OH 4701 Bu Et 2-SnMe.sub.3, 4-OMe 4702 Bu Et 2-SnMe.sub.3, 4-OMeF 4703 Bu Et 2-SnMe.sub.3, 4-OCF.sub.3 4704 Bu Et 2-SnMe.sub.3, 4-OEtF 4705 Bu Et 2-SnMe.sub.3, 4-OPrF 4706 Bu Et 2-OH, 2-SnMe.sub.3 4707 Bu Et 2-OMe, 4-SnMe.sub.3 4708 Bu Et 2-OMeF, 4-SnMe.sub.3 4709 Bu Et 4-OCF.sub.3, 4-SnMe.sub.3 4710 Pr Pr H 4711 Pr Pr 2-t-Bu 4712 Pr Pr 2-Br 4713 Pr Pr 3-Br 4714 Pr Pr 4-Br 4715 Pr Pr 2-I 4716 Pr Pr 3-I 4717 Pr Pr 4-I 4718 Pr Pr 2-SnMe.sub.3 4719 Pr Pr 3-SnMe.sub.3 4720 Pr Pr 4-SnMe.sub.3 4721 Pr Pr 2-Me 4722 Pr Pr 3-Me 4723 Pr Pr 4-Me 4724 Pr Pr 2-OH 4725 Pr Pr 3-OH 4726 Pr Pr 4-OH 4727 Pr Pr 2-OMe 4728 Pr Pr 3-OMe 4729 Pr Pr 4-OMe 4730 Pr Pr 2-OMeF 4731 Pr Pr 3-OMeF 4732 Pr Pr 4-OMeF 4733 Pr Pr 2-OCF.sub.3 4734 Pr Pr 3-OCF.sub.3 4735 Pr Pr 4-OCF.sub.3 4736 Pr Pr 2-OEtF 4737 Pr Pr 3-OEtF 4738 Pr Pr 4-OEtF 4739 Pr Pr 2-OPrF 4740 Pr Pr 3-OPrF 4741 Pr Pr 4-OPrF 4742 Pr Pr 2-SH 4743 Pr Pr 3-SH 4744 Pr Pr 4-SH 4745 Pr Pr 2-SMe 4746 Pr Pr 3-SMe 4747 Pr Pr 4-SMe 4748 Pr Pr 2-SMeF 4749 Pr Pr 3-SMeF 4750 Pr Pr 4-SMeF 4751 Pr Pr 2-SCF.sub.3 4752 Pr Pr 3-SCF.sub.3 4753 Pr Pr 4-SCF.sub.3 4754 Pr Pr 2-SEtF 4755 Pr Pr 3-SEtF 4756 Pr Pr 4-SEtF 4757 Pr Pr 2-SPrF 4758 Pr Pr 3-SPrF 4759 Pr Pr 4-SPrF 4760 Pr Pr 2-OMe, 4-OMe 4761 Pr Pr 2-Me, 5-OH 4762 Pr Pr 2-Me, 5-OMe 4763 Pr Pr 2-Me, 5-OMeF 4764 Pr Pr 2-Me, 5-OEtF 4765 Pr Pr 2-Me, 5-OPrF 4766 Pr Pr 2-Me, 4-OH 4767 Pr Pr 2-Me, 4-OMe 4768 Pr Pr 2-Me, 4-OMeF 4769 Pr Pr 2-Me, 4-OCF.sub.3 4770 Pr Pr 2-Me, 4-OEtF 4771 Pr Pr 2-Me, 4-OPrF 4772 Pr Pr 2-OH, 4-Me 4773 Pr Pr 2-OMe, 4-Me 4774 Pr Pr 2-OMeF, 4-Me 4775 Pr Pr 2-OCF.sub.3, 4-Me 4776 Pr Pr 2-OEtF, 4-Me 4777 Pr Pr 2-OPrF, 4-Me 4778 Pr Pr 2-Cl, 4-OH 4779 Pr Pr 2-Cl, 4-OMe 4780 Pr Pr 2-Cl, 4-OMeF 4781 Pr Pr 2-Cl, 4-OCF.sub.3 4782 Pr Pr 2-Cl, 4-OEtF 4783 Pr Pr 2-Cl, 4-OPrF 4784 Pr Pr 2-F, 4-F 4785 Pr Pr 2-Cl, 4-Cl 4786 Pr Pr 2-Cl, 4-F 4787 Pr Pr 2-Cl, 4-NO.sub.2 4788 Pr Pr 2-Cl, 4-NH.sub.2 4789 Pr Pr 2-Cl, 4-NHMe 4790 Pr Pr 2-Cl, 4-NMe.sub.2 4791 Pr Pr 2-Cl, 4-NMe.sub.3OTf 4792 Pr Pr 2-Cl, 4-NMe.sub.3I 4793 Pr Pr 2-Cl, 5-F 4794 Pr Pr 2-Cl, 5-NO.sub.2 4795 Pr Pr 2-Cl, 5-NH.sub.2 4796 Pr Pr 2-Cl, 5-NHMe 4797 Pr Pr 2-Cl, 5-NMe.sub.2 4798 Pr Pr 2-Cl, 5-NMe.sub.3OTf 4799 Pr Pr 2-Cl, 5-NMe.sub.3I 4800 Pr Pr 2-F, 4-Cl 4801 Pr Pr 2-NO.sub.2, 4-Cl 4802 Pr Pr 2-NH.sub.2, 4-Cl 4803 Pr Pr 2-NHMe, 4-Cl 4804 Pr Pr 2-NMe.sub.2, 4-Cl 4805 Pr Pr 2-NMe.sub.3OTf, 4-Cl 4806 Pr Pr 2-NMe.sub.3I, 4-Cl 4807 Pr Pr 2-F, 5-Cl 4808 Pr Pr 2-NO.sub.2, 5-Cl 4809 Pr Pr 2-NH.sub.2, 5-Cl 4810 Pr Pr 2-NHMe, 5-Cl 4811 Pr Pr 2-NMe.sub.2, 5-Cl 4812 Pr Pr 2-NMe.sub.3OTF, 5-Cl 4813 Pr Pr 2-NMe.sub.3I, 5-Cl 4814 Pr Pr 2-Br, 4-F 4815 Pr Pr 2-Br, 4-NO.sub.2 4816 Pr Pr 2-Br, 4-NH.sub.2 4817 Pr Pr 2-Br, 4-NHMe 4818 Pr Pr 2-Br, 4-NMe.sub.2 4819 Pr Pr 2-Br, 4-NMe.sub.3OTf 4820 Pr Pr 2-Br, 4-NMe.sub.3I 4821 Pr Pr 2-Br, 5-F 4822 Pr Pr 2-Br, 5-NO.sub.2 4823 Pr Pr 2-Br, 5-NH.sub.2 4824 Pr Pr 2-Br, 5-NHMe 4825 Pr Pr 2-Br, 5-NMe.sub.3 4826 Pr Pr 2-Br, 5-NMe.sub.3OTf 4827 Pr Pr 2-Br, 5-NMe.sub.3I 4828 Pr Pr 2-F, 4-Br 4829 Pr Pr 2-NO.sub.2, 4-Br 4830 Pr Pr 2-NH.sub.2, 4-Br 4831 Pr Pr 2-NHMe, 4-Br 4832 Pr Pr 2-NMe.sub.3, 4-Br 4833 Pr Pr 2-NMe.sub.3OTf, 4-Br 4834 Pr Pr 2-NMe.sub.3I, 4-Br 4835 Pr Pr 2-I, 4-F 4836 Pr Pr 2-I, 4-NO.sub.2 4837 Pr Pr 2-I, 4-NH.sub.2 4838 Pr Pr 2-I, 4-NHMe 4839 Pr Pr 2-I, 4-NMe.sub.2 4840 Pr Pr 2-I, 4-NMe.sub.3OTf 4841 Pr Pr 2-I, 4-NMe.sub.3I 4842 Pr Pr 2-F, 4-I 4843 Pr Pr 2-NO.sub.2, 4-I 4844 Pr Pr 2-NH.sub.2, 4-I 4845 Pr Pr 2-NHMe, 4-I 4846 Pr Pr 2-NMe.sub.2, 4-I 4847 Pr Pr 2-NMe.sub.3OTf, 4-I 4848 Pr Pr 2-NMe.sub.3I, 4-I 4849 Pr Pr 2-Me, 3-F 4850 Pr Pr 2-Me, 3-NO.sub.2 4851 Pr Pr 2-Me, 3-NH.sub.2 4852 Pr Pr 2-Me, 3-NHMe 4853 Pr Pr 2-Me, 3-NMe.sub.2 4854 Pr Pr 2-Me, 3-NMe.sub.3OTf 4855 Pr Pr 2-Me, 3-NMe.sub.3I 4856 Pr Pr 2-Me, 4-F 4857 Pr Pr 2-Me, 4-NO.sub.2 4858 Pr Pr 2-Me, 4-NH.sub.2 4859 Pr Pr 2-Me, 4-NHMe 4860 Pr Pr 2-Me, 4-NMe.sub.2 4861 Pr Pr 2-Me, 4-NMe.sub.3OTf 4862 Pr Pr 2-Me, 4-NMe.sub.3I 4863 Pr Pr 2-Me, 5-F 4864 Pr Pr 2-Me, 5-NO.sub.2 4865 Pr Pr 2-Me, 5-NH.sub.2 4866 Pr Pr 2-Me, 5-NHMe 4867 Pr Pr 2-Me, 5-NMe.sub.2 4868 Pr Pr 2-Me, 5-NMe.sub.3OTf 4869 Pr Pr 2-Me, 5-NMe.sub.3I 4870 Pr Pr 2-F, 4-Me 4871 Pr Pr 2-NO.sub.2, 4-Me 4872 Pr Pr 2-NH.sub.2, 4-Me 4873 Pr Pr 2-NHMe, 4-Me 4874 Pr Pr 2-NMe.sub.2, 4-Me 4875 Pr Pr 2-NMe.sub.3, 4-Me 4876 Pr Pr 2-NMe.sub.3OTf, 4-Me 4877 Pr Pr 2-NMe.sub.3I, 4-Me 4878 Pr Pr 2-SnMe.sub.3, 4-F 4879 Pr Pr 2-SnMe.sub.3, 5-F 4880 Pr Pr 2-F, 4-SnMe.sub.3 4881 Pr Pr 2-Br, 6-Cl, 4-F 4882 Pr Pr 2-Br, 6-Cl, 4-NO.sub.2 4883 Pr Pr 2-Br, 6-Cl, 4-NH.sub.2 4884 Pr Pr 2-Br, 6-Cl, 4-NHMe 4885 Pr Pr 2-Br, 6-Cl, 4-NMe.sub.2 4886 Pr Pr 2-Br, 6-Cl, 4-NMe.sub.3OTf 4887 Pr Pr 2-Br, 6-Cl, 4-NMe.sub.3I 4888 Pr Pr 2-Me, 6-Cl, 4-F 4889 Pr Pr 2-SnMe.sub.3, 6-Cl, 4-F 4890 Pr Pr 2-Cl, 4-Me 4891 Pr Pr 2-Cl, 4-Br 4892 Pr Pr 2-Cl, 4-SnMe.sub.3 4893 Pr Pr 2-Br, 4-Cl 4894 Pr Pr 2-SnMe.sub.3, 4-Cl 4895 Pr Pr 2-Me, 4-Cl 4896 Pr Pr 2-Br, 4-Br 4897 Pr Pr 2-Br, 4-Me 4898 Pr Pr 2-Br, 4-SnMe.sub.3 4899 Pr Pr 2-SnMe.sub.3, 4-Br 4900 Pr Pr 2-Me, 4-Br 4901 Pr Pr 2-Me, 4-SnMe.sub.3 4902 Pr Pr 2-SnMe.sub.3, 4-Me 4903 Pr Pr 2-Me, 4-Me 4904 Pr Pr 2-Et, 4-Br 4905 Pr Pr 2-Et, 4-SnMe.sub.3 4906 Pr Pr 2-Et, 4-Me 4907 Pr Pr 2-Me, 4-Me, 6-Me 4908 Pr Pr 2-Me, 4-Br, 6-Me 4909 Pr Pr 2-Me, 4-SnMe.sub.3, 6-Me 4910 Pr Pr 2-Et, 6-Me 4911 Pr Pr 2-Br, 4-i-Pr 4912 Pr Pr 2-SnMe.sub.3, 4-i-Pr 4913 Pr Pr 2-Me, 4-i-Pr 4914 Pr Pr 2-Br, 4-Br, 6-Br 4915 Pr Pr 2-Br, 4-Me, 6-Br 4916 Pr Pr 2-Br, 4-SnMe.sub.3, 6-Br 4917 Pr Pr 2-SnMe.sub.3, 4,6-Br 4918 Pr Pr 2-Br, 4-Br, 6-Me 4919 Pr Pr 2-Br, 4-CF.sub.3, 6-Br 4920 Pr Pr 2-Br, 4-Br, 6-CF.sub.3 4921 Pr Pr 2-CF.sub.3, 4-CF.sub.3 4922 Pr Pr 2-Cl, 4-CF.sub.3 4923 Pr Pr 2-CF.sub.3, 4-Cl 4924 Pr Pr 2-Br, 4-CF.sub.3 4925 Pr Pr 2-SnMe.sub.3, 4-CF.sub.3 4926 Pr Pr 2-Me, 4-CF.sub.3 4927 Pr Pr 2-CF.sub.3, 4-Br 4928 Pr Pr 2-CF.sub.3, 4-SnMe.sub.3 4929 Pr Pr 2-CF.sub.3, 4-Me 4930 Pr Pr 2-Br, 4-OH 4931 Pr Pr 2-Br, 4-OMe 4932 Pr Pr 2-Br, 4-OMeF 4933 Pr Pr 2-Br, 4-OCF.sub.3 4934 Pr Pr 2-Br, 4-OEtF 4935 Pr Pr 2-Br, 4-OPrF 4936 Pr Pr 2-OH, 4-Br 4937 Pr Pr 2-OMe, 4-Br 4938 Pr Pr 2-OMeF, 4-Br 4939 Pr Pr 2-OCF.sub.3, 4-Br 4940 Pr Pr 2-OEtF, 4-Br 4941 Pr Pr 2-OPrF, 4-Br 4942 Pr Pr 2-I, 4-OH 4943 Pr Pr 2-I, 4-OMe 4944 Pr Pr 2-I, 4-OMeF 4945 Pr Pr 2-I, 4-OCF.sub.3 4946 Pr Pr 2-I, 4-OEtF 4947 Pr Pr 2-I, 4-OPrF 4948 Pr Pr 2-OH, 4-I

4949 Pr Pr 2-OMe, 4-I 4950 Pr Pr 2-OMeF, 4-I 4951 Pr Pr 2-OCF.sub.3, 4-I 4952 Pr Pr 2-OEtF, 4-I 4953 Pr Pr 2-OPrF, 4-I 4954 Pr Pr 2-SnMe.sub.3, 4-OH 4955 Pr Pr 2-SnMe.sub.3, 4-OMe 4956 Pr Pr 2-SnMe.sub.3, 4-OMeF 4957 Pr Pr 2-SnMe.sub.3, 4-OCF.sub.3 4958 Pr Pr 2-SnMe.sub.3, 4-OEtF 4959 Pr Pr 2-SnMe.sub.3, 4-OPrF 4960 Pr Pr 2-OH, 2-SnMe.sub.3 4961 Pr Pr 2-OMe, 4-SnMe.sub.3 4962 Pr Pr 2-OMeF, 4-SnMe.sub.3 4963 Pr Pr 4-OCF.sub.3, 4-SnMe.sub.3 4964 Pr Pr 2-OEtF, 4-SnMe.sub.3 4965 Pr Pr 2-OPrF, 4-SnMe.sub.3 4966 Pr Pr-F H 4967 Pr Pr-F 2-t-Bu 4968 Pr Pr-F 2-Br 4969 Pr Pr-F 3-Br 4970 Pr Pr-F 4-Br 4971 Pr Pr-F 2-I 4972 Pr Pr-F 3-I 4973 Pr Pr-F 4-I 4974 Pr Pr-F 2-SnMe.sub.3 4975 Pr Pr-F 3-SnMe.sub.3 4976 Pr Pr-F 4-SnMe.sub.3 4977 Pr Pr-F 2-Me 4978 Pr Pr-F 3-Me 4979 Pr Pr-F 4-Me 4980 Pr Pr-F 2-OH 4981 Pr Pr-F 3-OH 4982 Pr Pr-F 4-OH 4983 Pr Pr-F 2-OMe 4984 Pr Pr-F 3-OMe 4985 Pr Pr-F 4-OMe 4986 Pr Pr-F 2-OMeF 4987 Pr Pr-F 3-OMeF 4988 Pr Pr-F 4-OMeF 4989 Pr Pr-F 2-OCF.sub.3 4990 Pr Pr-F 3-OCF.sub.3 4991 Pr Pr-F 4-OCF.sub.3 4992 Pr Pr-F 2-OEtF 4993 Pr Pr-F 3-OEtF 4994 Pr Pr-F 4-OEtF 4995 Pr Pr-F 2-OPrF 4996 Pr Pr-F 3-OPrF 4997 Pr Pr-F 4-OPrF 4998 Pr Pr-F 2-SH 4999 Pr Pr-F 3-SH 5000 Pr Pr-F 4-SH 5001 Pr Pr-F 2-SMe 5002 Pr Pr-F 3-SMe 5003 Pr Pr-F 4-SMe 5004 Pr Pr-F 2-SMeF 5005 Pr Pr-F 3-SMeF 5006 Pr Pr-F 4-SMeF 5007 Pr Pr-F 2-SCF.sub.3 5008 Pr Pr-F 3-SCF.sub.3 5009 Pr Pr-F 4-SCF.sub.3 5010 Pr Pr-F 2-SEtF 5011 Pr Pr-F 3-SEtF 5012 Pr Pr-F 4-SEtF 5013 Pr Pr-F 2-SPrF 5014 Pr Pr-F 3-SPrF 5015 Pr Pr-F 4-SPrF 5016 Pr Pr-F 2-OMe, 4-OMe 5017 Pr Pr-F 2-Me, 5-OH 5018 Pr Pr-F 2-Me, 5-OMe 5019 Pr Pr-F 2-Me, 5-OMeF 5020 Pr Pr-F 2-Me, 5-OEtF 5021 Pr Pr-F 2-Me, 5-OPrF 5022 Pr Pr-F 2-Me, 4-OH 5023 Pr Pr-F 2-Me, 4-OMe 5024 Pr Pr-F 2-Me, 4-OMeF 5025 Pr Pr-F 2-Me, 4-OCF.sub.3 5026 Pr Pr-F 2-Me, 4-OEtF 5027 Pr Pr-F 2-Me, 4-OPrF 5028 Pr Pr-F 2-OH, 4-Me 5029 Pr Pr-F 2-OMe, 4-Me 5030 Pr Pr-F 2-OMeF, 4-Me 5031 Pr Pr-F 2-OCF.sub.3, 4-Me 5032 Pr Pr-F 2-OEtF, 4-Me 5033 Pr Pr-F 2-OPrF, 4-Me 5034 Pr Pr-F 2-Cl, 4-OH 5035 Pr Pr-F 2-Cl, 4-OMe 5036 Pr Pr-F 2-Cl, 4-OMeF 5037 Pr Pr-F 2-Cl, 4-OCF.sub.3 5038 Pr Pr-F 2-Cl, 4-OEtF 5039 Pr Pr-F 2-Cl, 4-OPrF 5040 Pr Pr-F 2-F, 4-F 5041 Pr Pr-F 2-Cl, 4-Cl 5042 Pr Pr-F 2-Cl, 4-F 5043 Pr Pr-F 2-Cl, 4-NO.sub.2 5044 Pr Pr-F 2-Cl, 4-NH.sub.2 5045 Pr Pr-F 2-Cl, 4-NHMe 5046 Pr Pr-F 2-Cl, 4-NMe.sub.2 5047 Pr Pr-F 2-Cl, 4-NMe.sub.3OTf 5048 Pr Pr-F 2-Cl, 4-NMe.sub.3I 5049 Pr Pr-F 2-Cl, 5-F 5050 Pr Pr-F 2-Cl, 5-NO.sub.2 5051 Pr Pr-F 2-Cl, 5-NH.sub.2 5052 Pr Pr-F 2-Cl, 5-NHMe 5053 Pr Pr-F 2-Cl, 5-NMe.sub.2 5054 Pr Pr-F 2-Cl, 5-NMe.sub.3OTf 5055 Pr Pr-F 2-Cl, 5-NMe.sub.3I 5056 Pr Pr-F 2-F, 4-Cl 5057 Pr Pr-F 2-NO.sub.2, 4-Cl 5058 Pr Pr-F 2-NH.sub.2, 4-Cl 5059 Pr Pr-F 2-NHMe, 4-Cl 5060 Pr Pr-F 2-NMe.sub.2, 4-Cl 5061 Pr Pr-F 2-NMe.sub.3OTf, 4-Cl 5062 Pr Pr-F 2-NMe.sub.3I, 4-Cl 5063 Pr Pr-F 2-F, 5-Cl 5064 Pr Pr-F 2-NO.sub.2, 5-Cl 5065 Pr Pr-F 2-NH.sub.2, 5-Cl 5066 Pr Pr-F 2-NHMe, 5-Cl 5067 Pr Pr-F 2-NMe.sub.2, 5-Cl 5068 Pr Pr-F 2-NMe.sub.3OTF, 5-Cl 5069 Pr Pr-F 2-NMe.sub.3I, 5-Cl 5070 Pr Pr-F 2-Br, 4-F 5071 Pr Pr-F 2-Br, 4-NO.sub.2 5072 Pr Pr-F 2-Br, 4-NH.sub.2 5073 Pr Pr-F 2-Br, 4-NHMe 5074 Pr Pr-F 2-Br, 4-NMe.sub.2 5075 Pr Pr-F 2-Br, 4-NMe.sub.3OTf 5076 Pr Pr-F 2-Br, 4-NMe.sub.3I 5077 Pr Pr-F 2-Br, 5-F 5078 Pr Pr-F 2-Br, 5-NO.sub.2 5079 Pr Pr-F 2-Br, 5-NH.sub.2 5080 Pr Pr-F 2-Br, 5-NHMe 5081 Pr Pr-F 2-Br, 5-NMe.sub.3 5082 Pr Pr-F 2-Br, 5-NMe.sub.3OTf 5083 Pr Pr-F 2-Br, 5-NMe.sub.3I 5084 Pr Pr-F 2-F, 4-Br 5085 Pr Pr-F 2-NO.sub.2, 4-Br 5086 Pr Pr-F 2-NH.sub.2, 4-Br 5087 Pr Pr-F 2-NHMe, 4-Br 5088 Pr Pr-F 2-NMe.sub.3, 4-Br 5089 Pr Pr-F 2-NMe.sub.3OTf, 4-Br 5090 Pr Pr-F 2-NMe.sub.3I, 4-Br 5091 Pr Pr-F 2-I, 4-F 5092 Pr Pr-F 2-I, 4-NO.sub.2 5093 Pr Pr-F 2-I, 4-NH.sub.2 5094 Pr Pr-F 2-I, 4-NHMe 5095 Pr Pr-F 2-I, 4-NMe.sub.2 5096 Pr Pr-F 2-I, 4-NMe.sub.3OTf 5097 Pr Pr-F 2-I, 4-NMe.sub.3I 5098 Pr Pr-F 2-F, 4-I 5099 Pr Pr-F 2-NO.sub.2, 4-I 5100 Pr Pr-F 2-NH.sub.2, 4-I 5101 Pr Pr-F 2-NHMe, 4-I 5102 Pr Pr-F 2-NMe.sub.2, 4-I 5103 Pr Pr-F 2-NMe.sub.3OTf, 4-I 5104 Pr Pr-F 2-NMe.sub.3I, 4-I 5105 Pr Pr-F 2-Me, 3-F 5106 Pr Pr-F 2-Me, 3-NO.sub.2 5107 Pr Pr-F 2-Me, 3-NH.sub.2 5108 Pr Pr-F 2-Me, 3-NHMe 5109 Pr Pr-F 2-Me, 3-NMe.sub.2 5110 Pr Pr-F 2-Me, 3-NMe.sub.3OTf 5111 Pr Pr-F 2-Me, 3-NMe.sub.3I 5112 Pr Pr-F 2-Me, 4-F 5113 Pr Pr-F 2-Me, 4-NO.sub.2 5114 Pr Pr-F 2-Me, 4-NH.sub.2 5115 Pr Pr-F 2-Me, 4-NHMe 5116 Pr Pr-F 2-Me, 4-NMe.sub.2 5117 Pr Pr-F 2-Me, 4-NMe.sub.3OTf 5118 Pr Pr-F 2-Me, 4-NMe.sub.3I 5119 Pr Pr-F 2-Me, 5-F 5120 Pr Pr-F 2-Me, 5-NO.sub.2 5121 Pr Pr-F 2-Me, 5-NH.sub.2 5122 Pr Pr-F 2-Me, 5-NHMe 5123 Pr Pr-F 2-Me, 5-NMe.sub.2 5124 Pr Pr-F 2-Me, 5-NMe.sub.3OTf 5125 Pr Pr-F 2-Me, 5-NMe.sub.3I 5126 Pr Pr-F 2-F, 4-Me 5127 Pr Pr-F 2-NO.sub.2, 4-Me 5128 Pr Pr-F 2-NH.sub.2, 4-Me 5129 Pr Pr-F 2-NHMe, 4-Me 5130 Pr Pr-F 2-NMe.sub.2, 4-Me 5131 Pr Pr-F 2-NMe.sub.3, 4-Me 5132 Pr Pr-F 2-NMe.sub.3OTf, 4-Me 5133 Pr Pr-F 2-NMe.sub.3I, 4-Me 5134 Pr Pr-F 2-SnMe.sub.3, 4-F 5135 Pr Pr-F 2-SnMe.sub.3, 5-F 5136 Pr Pr-F 2-F, 4-SnMe.sub.3 5137 Pr Pr-F 2-Br, 6-Cl, 4-F 5138 Pr Pr-F 2-Br, 6-Cl, 4-NO.sub.2 5139 Pr Pr-F 2-Br, 6-Cl, 4-NH.sub.2 5140 Pr Pr-F 2-Br, 6-Cl, 4-NHMe 5141 Pr Pr-F 2-Br, 6-Cl, 4-NMe.sub.2 5142 Pr Pr-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 5143 Pr Pr-F 2-Br, 6-Cl, 4-NMe.sub.3I 5144 Pr Pr-F 2-Me, 6-Cl, 4-F 5145 Pr Pr-F 2-SnMe.sub.3, 6-Cl, 4-F 5146 Pr Pr-F 2-Cl, 4-Me 5147 Pr Pr-F 2-Cl, 4-Br 5148 Pr Pr-F 2-Cl, 4-SnMe.sub.3 5149 Pr Pr-F 2-Br, 4-Cl 5150 Pr Pr-F 2-SnMe.sub.3, 4-Cl 5151 Pr Pr-F 2-Me, 4-Cl 5152 Pr Pr-F 2-Br, 4-Br 5153 Pr Pr-F 2-Br, 4-Me 5154 Pr Pr-F 2-Br, 4-SnMe.sub.3 5155 Pr Pr-F 2-SnMe.sub.3, 4-Br 5156 Pr Pr-F 2-Me, 4-Br 5157 Pr Pr-F 2-Me, 4-SnMe.sub.3 5158 Pr Pr-F 2-SnMe.sub.3, 4-Me 5159 Pr Pr-F 2-Me, 4-Me 5160 Pr Pr-F 2-Et, 4-Br 5161 Pr Pr-F 2-Et, 4-SnMe.sub.3 5162 Pr Pr-F 2-Et, 4-Me 5163 Pr Pr-F 2-Me, 4-Me, 6-Me 5164 Pr Pr-F 2-Me, 4-Br, 6-Me 5165 Pr Pr-F 2-Me, 4-SnMe.sub.3, 6-Me 5166 Pr Pr-F 2-Et, 6-Me 5167 Pr Pr-F 2-Br, 4-i-Pr 5168 Pr Pr-F 2-SnMe.sub.3, 4-i-Pr 5169 Pr Pr-F 2-Me, 4-i-Pr 5170 Pr Pr-F 2-Br, 4-Br, 6-Br 5171 Pr Pr-F 2-Br, 4-Me, 6-Br 5172 Pr Pr-F 2-Br, 4-SnMe.sub.3, 6-Br 5173 Pr Pr-F 2-SnMe.sub.3, 4-Br, 6-Br 5174 Pr Pr-F 2-Br, 4-Br, 6-Me 5175 Pr Pr-F 2-Br, 4-CF.sub.3, 6-Br 5176 Pr Pr-F 2-Br, 4-Br, 6-CF.sub.3 5177 Pr Pr-F 2-CF.sub.3, 4-CF.sub.3 5178 Pr Pr-F 2-Cl, 4-CF.sub.3 5179 Pr Pr-F 2-CF.sub.3, 4-Cl 5180 Pr Pr-F 2-Br, 4-CF.sub.3 5181 Pr Pr-F 2-SnMe.sub.3, 4-CF.sub.3 5182 Pr Pr-F 2-Me, 4-CF.sub.3 5183 Pr Pr-F 2-CF.sub.3, 4-Br 5184 Pr Pr-F 2-CF.sub.3, 4-SnMe.sub.3 5185 Pr Pr-F 2-CF.sub.3, 4-Me 5186 Pr Pr-F 2-Br, 4-OH 5187 Pr Pr-F 2-Br, 4-OMe 5188 Pr Pr-F 2-Br, 4-OMeF 5189 Pr Pr-F 2-Br, 4-OCF.sub.3 5190 Pr Pr-F 2-Br, 4-OEtF 5191 Pr Pr-F 2-Br, 4-OPrF 5192 Pr Pr-F 2-OH, 4-Br 5193 Pr Pr-F 2-OMe, 4-Br 5194 Pr Pr-F 2-OMeF, 4-Br 5195 Pr Pr-F 2-OCF.sub.3, 4-Br 5196 Pr Pr-F 2-OEtF, 4-Br 5197 Pr Pr-F 2-OPrF, 4-Br 5198 Pr Pr-F 2-I, 4-OH 5199 Pr Pr-F 2-I, 4-OMe

5200 Pr Pr-F 2-I, 4-OMeF 5201 Pr Pr-F 2-I, 4-OCF.sub.3 5202 Pr Pr-F 2-I, 4-OEtF 5203 Pr Pr-F 2-I, 4-OPrF 5204 Pr Pr-F 2-OH, 4-I 5205 Pr Pr-F 2-OMe, 4-I 5206 Pr Pr-F 2-OMeF, 4-I 5207 Pr Pr-F 2-OCF.sub.3, 4-I 5208 Pr Pr-F 2-OEtF, 4-I 5209 Pr Pr-F 2-OPrF, 4-I 5210 Pr Pr-F 2-SnMe.sub.3, 4-OH 5211 Pr Pr-F 2-SnMe.sub.3, 4-OMe 5212 Pr Pr-F 2-SnMe.sub.3, 4-OMeF 5213 Pr Pr-F 2-SnMe.sub.3, 4-OCF.sub.3 5214 Pr Pr-F 2-SnMe.sub.3, 4-OEtF 5215 Pr Pr-F 2-SnMe.sub.3, 4-OPrF 5216 Pr Pr-F 2-OH, 2-SnMe.sub.3 5217 Pr Pr-F 2-OMe, 4-SnMe.sub.3 5218 Pr Pr-F 2-OMeF, 4-SnMe.sub.3 5219 Pr Pr-F 4-OCF.sub.3, 4-SnMe.sub.3 5220 Pr Pr-F 2-OEtF, 4-SnMe.sub.3 5221 Pr Pr-F 2-OPrF, 4-SnMe.sub.3 5222 Pr Et-F H 5223 Pr Et-F 2-t-Bu 5224 Pr Et-F 2-Br 5225 Pr Et-F 3-Br 5226 Pr Et-F 4-Br 5227 Pr Et-F 2-I 5228 Pr Et-F 3-I 5229 Pr Et-F 4-I 5230 Pr Et-F 2-SnMe.sub.3 5231 Pr Et-F 3-SnMe.sub.3 5232 Pr Et-F 4-SnMe.sub.3 5233 Pr Et-F 2-Me 5234 Pr Et-F 3-Me 5235 Pr Et-F 4-Me 5236 Pr Et-F 2-OH 5237 Pr Et-F 3-OH 5238 Pr Et-F 4-OH 5239 Pr Et-F 2-OMe 5240 Pr Et-F 3-OMe 5241 Pr Et-F 4-OMe 5242 Pr Et-F 2-OMeF 5243 Pr Et-F 3-OMeF 5244 Pr Et-F 4-OMeF 5245 Pr Et-F 2-OCF.sub.3 5246 Pr Et-F 3-OCF.sub.3 5247 Pr Et-F 4-OCF.sub.3 5248 Pr Et-F 2-OEtF 5249 Pr Et-F 3-OEtF 5250 Pr Et-F 4-OEtF 5251 Pr Et-F 2-OPrF 5252 Pr Et-F 3-OPrF 5253 Pr Et-F 4-OPrF 5254 Pr Et-F 2-SH 5255 Pr Et-F 3-SH 5256 Pr Et-F 4-SH 5257 Pr Et-F 2-SMe 5258 Pr Et-F 3-SMe 5259 Pr Et-F 4-SMe 5260 Pr Et-F 2-SMeF 5261 Pr Et-F 3-SMeF 5262 Pr Et-F 4-SMeF 5263 Pr Et-F 2-SCF.sub.3 5264 Pr Et-F 3-SCF.sub.3 5265 Pr Et-F 4-SCF.sub.3 5266 Pr Et-F 2-SEtF 5267 Pr Et-F 3-SEtF 5268 Pr Et-F 4-SEtF 5269 Pr Et-F 2-SPrF 5270 Pr Et-F 3-SPrF 5271 Pr Et-F 4-SPrF 5272 Pr Et-F 2-OMe, 4-OMe 5273 Pr Et-F 2-Me, 5-OH 5274 Pr Et-F 2-Me, 5-OMe 5275 Pr Et-F 2-Me, 5-OMeF 5276 Pr Et-F 2-Me, 5-OEtF 5277 Pr Et-F 2-Me, 5-OPrF 5278 Pr Et-F 2-Me, 4-OH 5279 Pr Et-F 2-Me, 4-OMe 5280 Pr Et-F 2-Me, 4-OMeF 5281 Pr Et-F 2-Me, 4-OCF.sub.3 5282 Pr Et-F 2-Me, 4-OEtF 5283 Pr Et-F 2-Me, 4-OPrF 5284 Pr Et-F 2-OH, 4-Me 5285 Pr Et-F 2-OMe, 4-Me 5286 Pr Et-F 2-OMeF, 4-Me 5287 Pr Et-F 2-OCF.sub.3, 4-Me 5288 Pr Et-F 2-OEtF, 4-Me 5289 Pr Et-F 2-OPrF, 4-Me 5290 Pr Et-F 2-Cl, 4-OH 5291 Pr Et-F 2-Cl, 4-OMe 5292 Pr Et-F 2-Cl, 4-OMeF 5293 Pr Et-F 2-Cl, 4-OCF.sub.3 5294 Pr Et-F 2-Cl, 4-OEtF 5295 Pr Et-F 2-Cl, 4-OPrF 5296 Pr Et-F 2-F, 4-F 5297 Pr Et-F 2-Cl, 4-Cl 5298 Pr Et-F 2-Cl, 4-F 5299 Pr Et-F 2-Cl, 4-NO.sub.2 5300 Pr Et-F 2-Cl, 4-NH.sub.2 5301 Pr Et-F 2-Cl, 4-NHMe 5302 Pr Et-F 2-Cl, 4-NMe.sub.2 5303 Pr Et-F 2-Cl, 4-NMe.sub.3OTf 5304 Pr Et-F 2-Cl, 4-NMe.sub.3I 5305 Pr Et-F 2-Cl, 5-F 5306 Pr Et-F 2-Cl, 5-NO.sub.2 5307 Pr Et-F 2-Cl, 5-NH.sub.2 5308 Pr Et-F 2-Cl, 5-NHMe 5309 Pr Et-F 2-Cl, 5-NMe.sub.2 5310 Pr Et-F 2-Cl, 5-NMe.sub.3OTf 5311 Pr Et-F 2-Cl, 5-NMe.sub.3I 5312 Pr Et-F 2-F, 4-Cl 5313 Pr Et-F 2-NO.sub.2, 4-Cl 5314 Pr Et-F 2-NH.sub.2, 4-Cl 5315 Pr Et-F 2-NHMe, 4-Cl 5316 Pr Et-F 2-NMe.sub.2, 4-Cl 5317 Pr Et-F 2-NMe.sub.3OTf, 4-Cl 5318 Pr Et-F 2-NMe.sub.3I, 4-Cl 5319 Pr Et-F 2-F, 5-Cl 5320 Pr Et-F 2-NO.sub.2, 5-Cl 5321 Pr Et-F 2-NH.sub.2, 5-Cl 5322 Pr Et-F 2-NHMe, 5-Cl 5323 Pr Et-F 2-NMe.sub.2, 5-Cl 5324 Pr Et-F 2-NMe.sub.3OTF, 5-Cl 5325 Pr Et-F 2-NMe.sub.3I, 5-Cl 5326 Pr Et-F 2-Br, 4-F 5327 Pr Et-F 2-Br, 4-NO.sub.2 5328 Pr Et-F 2-Br, 4-NH.sub.2 5329 Pr Et-F 2-Br, 4-NHMe 5330 Pr Et-F 2-Br, 4-NMe.sub.2 5331 Pr Et-F 2-Br, 4-NMe.sub.3OTf 5332 Pr Et-F 2-Br, 4-NMe.sub.3I 5333 Pr Et-F 2-Br, 5-F 5334 Pr Et-F 2-Br, 5-NO.sub.2 5335 Pr Et-F 2-Br, 5-NH.sub.2 5336 Pr Et-F 2-Br, 5-NHMe 5337 Pr Et-F 2-Br, 5-NMe.sub.3 5338 Pr Et-F 2-Br, 5-NMe.sub.3OTf 5339 Pr Et-F 2-Br, 5-NMe.sub.3I 5340 Pr Et-F 2-F, 4-Br 5341 Pr Et-F 2-NO.sub.2, 4-Br 5342 Pr Et-F 2-NH.sub.2, 4-Br 5343 Pr Et-F 2-NHMe, 4-Br 5344 Pr Et-F 2-NMe.sub.3, 4-Br 5345 Pr Et-F 2-NMe.sub.3OTf, 4-Br 5346 Pr Et-F 2-NMe.sub.3I, 4-Br 5347 Pr Et-F 2-I, 4-F 5348 Pr Et-F 2-I, 4-NO.sub.2 5349 Pr Et-F 2-I, 4-NH.sub.2 5350 Pr Et-F 2-I, 4-NHMe 5351 Pr Et-F 2-I, 4-NMe.sub.2 5352 Pr Et-F 2-I, 4-NMe.sub.3OTf 5353 Pr Et-F 2-I, 4-NMe.sub.3I 5354 Pr Et-F 2-F, 4-I 5355 Pr Et-F 2-NO.sub.2, 4-I 5356 Pr Et-F 2-NH.sub.2, 4-I 5357 Pr Et-F 2-NHMe, 4-I 5358 Pr Et-F 2-NMe.sub.2, 4-I 5359 Pr Et-F 2-NMe.sub.3OTf, 4-I 5360 Pr Et-F 2-NMe.sub.3I, 4-I 5361 Pr Et-F 2-Me, 3-F 5362 Pr Et-F 2-Me, 3-NO.sub.2 5363 Pr Et-F 2-Me, 3-NH.sub.2 5364 Pr Et-F 2-Me, 3-NHMe 5365 Pr Et-F 2-Me, 3-NMe.sub.2 5366 Pr Et-F 2-Me, 3-NMe.sub.3OTf 5367 Pr Et-F 2-Me, 3-NMe.sub.3I 5368 Pr Et-F 2-Me, 4-F 5369 Pr Et-F 2-Me, 4-NO.sub.2 5370 Pr Et-F 2-Me, 4-NH.sub.2 5371 Pr Et-F 2-Me, 4-NHMe 5372 Pr Et-F 2-Me, 4-NMe.sub.2 5373 Pr Et-F 2-Me, 4-NMe.sub.3OTf 5374 Pr Et-F 2-Me, 4-NMe.sub.3I 5375 Pr Et-F 2-Me, 5-F 5376 Pr Et-F 2-Me, 5-NO.sub.2 5377 Pr Et-F 2-Me, 5-NH.sub.2 5378 Pr Et-F 2-Me, 5-NHMe 5379 Pr Et-F 2-Me, 5-NMe.sub.2 5380 Pr Et-F 2-Me, 5-NMe.sub.3OTf 5381 Pr Et-F 2-Me, 5-NMe.sub.3I 5382 Pr Et-F 2-F, 4-Me 5383 Pr Et-F 2-NO.sub.2, 4-Me 5384 Pr Et-F 2-NH.sub.2, 4-Me 5385 Pr Et-F 2-NHMe, 4-Me 5386 Pr Et-F 2-NMe.sub.2, 4-Me 5387 Pr Et-F 2-NMe.sub.3, 4-Me 5388 Pr Et-F 2-NMe.sub.3OTf, 4-Me 5389 Pr Et-F 2-NMe.sub.3I, 4-Me 5390 Pr Et-F 2-SnMe.sub.3, 4-F 5391 Pr Et-F 2-SnMe.sub.3, 5-F 5392 Pr Et-F 2-F, 4-SnMe.sub.3 5393 Pr Et-F 2-Br, 6-Cl, 4-F 5394 Pr Et-F 2-Br, 6-Cl, 4-NO.sub.2 5395 Pr Et-F 2-Br, 6-Cl, 4-NH.sub.2 5396 Pr Et-F 2-Br, 6-Cl, 4-NHMe 5397 Pr Et-F 2-Br, 6-Cl, 4-NMe.sub.2 5398 Pr Et-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 5399 Pr Et-F 2-Br, 6-Cl, 4-NMe.sub.3I 5400 Pr Et-F 2-Me, 6-Cl, 4-F 5401 Pr Et-F 2-SnMe.sub.3, 6-Cl, 4-F 5402 Pr Et-F 2-Cl, 4-Me 5403 Pr Et-F 2-Cl, 4-Br 5404 Pr Et-F 2-Cl, 4-SnMe.sub.3 5405 Pr Et-F 2-Br, 4-Cl 5406 Pr Et-F 2-SnMe.sub.3, 4-Cl 5407 Pr Et-F 2-Me, 4-Cl 5408 Pr Et-F 2-Br, 4-Br 5409 Pr Et-F 2-Br, 4-Me 5410 Pr Et-F 2-Br, 4-SnMe.sub.3 5411 Pr Et-F 2-SnMe.sub.3, 4-Br 5412 Pr Et-F 2-Me, 4-Br 5413 Pr Et-F 2-Me, 4-SnMe.sub.3 5414 Pr Et-F 2-SnMe.sub.3, 4-Me 5415 Pr Et-F 2-Me, 4-Me 5416 Pr Et-F 2-Et, 4-Br 5417 Pr Et-F 2-Et, 4-SnMe.sub.3 5418 Pr Et-F 2-Et, 4-Me 5419 Pr Et-F 2-Me, 4-Me, 6-Me 5420 Pr Et-F 2-Me, 4-Br, 6-Me 5421 Pr Et-F 2-Me, 4-SnMe.sub.3, 6-Me 5422 Pr Et-F 2-Et, 6-Me 5423 Pr Et-F 2-Br, 4-i-Pr 5424 Pr Et-F 2-SnMe.sub.3, 4-i-Pr 5425 Pr Et-F 2-Me, 4-i-Pr 5426 Pr Et-F 2-Br, 4-Br, 6-Br 5427 Pr Et-F 2-Br, 4-Me, 6-Br 5428 Pr Et-F 2-Br, 4-SnMe.sub.3, 6-Br 5429 Pr Et-F 2-SnMe.sub.3, 4-Br, 6-Br 5430 Pr Et-F 2-Br, 4-Br, 6-Me 5431 Pr Et-F 2-Br, 4-CF.sub.3, 6-Br 5432 Pr Et-F 2-Br, 4-Br, 6-CF.sub.3 5433 Pr Et-F 2-CF.sub.3, 4-CF.sub.3 5434 Pr Et-F 2-Cl, 4-CF.sub.3 5435 Pr Et-F 2-CF.sub.3, 4-Cl 5436 Pr Et-F 2-Br, 4-CF.sub.3 5437 Pr Et-F 2-SnMe.sub.3, 4-CF.sub.3 5438 Pr Et-F 2-Me, 4-CF.sub.3 5439 Pr Et-F 2-CF.sub.3, 4-Br 5440 Pr Et-F 2-CF.sub.3, 4-SnMe.sub.3 5441 Pr Et-F 2-CF.sub.3, 4-Me 5442 Pr Et-F 2-Br, 4-OH 5443 Pr Et-F 2-Br, 4-OMe 5444 Pr Et-F 2-Br, 4-OMeF 5445 Pr Et-F 2-Br, 4-OCF.sub.3 5446 Pr Et-F 2-Br, 4-OEtF 5447 Pr Et-F 2-Br, 4-OPrF 5448 Pr Et-F 2-OH, 4-Br 5449 Pr Et-F 2-OMe, 4-Br 5450 Pr Et-F 2-OMeF, 4-Br

5451 Pr Et-F 2-OCF.sub.3, 4-Br 5452 Pr Et-F 2-OEtF, 4-Br 5453 Pr Et-F 2-OPrF, 4-Br 5454 Pr Et-F 2-I, 4-OH 5455 Pr Et-F 2-I, 4-OMe 5456 Pr Et-F 2-I, 4-OMeF 5457 Pr Et-F 2-I, 4-OCF.sub.3 5458 Pr Et-F 2-I, 4-OEtF 5459 Pr Et-F 2-I, 4-OPrF 5460 Pr Et-F 2-OH, 4-I 5461 Pr Et-F 2-OMe, 4-I 5462 Pr Et-F 2-OMeF, 4-I 5463 Pr Et-F 2-OCF.sub.3, 4-I 5464 Pr Et-F 2-OEtF, 4-I 5465 Pr Et-F 2-OPrF, 4-I 5466 Pr Et-F 2-SnMe.sub.3, 4-OH 5467 Pr Et-F 2-SnMe.sub.3, 4-OMe 5468 Pr Et-F 2-SnMe.sub.3, 4-OMeF 5469 Pr Et-F 2-SnMe.sub.3, 4-OCF.sub.3 5470 Pr Et-F 2-SnMe.sub.3, 4-OEtF 5471 Pr Et-F 2-SnMe.sub.3, 4-OPrF 5472 Pr Et-F 2-OH, 2-SnMe.sub.3 5473 Pr Et-F 2-OMe, 4-SnMe.sub.3 5474 Pr Et-F 2-OMeF, 4-SnMe.sub.3 5475 Pr Et-F 4-OCF.sub.3, 4-SnMe.sub.3 5476 Pr Et-F 2-OEtF, 4-SnMe.sub.3 5477 Pr Et-F 2-OPrF, 4-SnMe.sub.3 5478 Pr-F Et H 5479 Pr-F Et 2-t-Bu 5480 Pr-F Et 2-Br 5481 Pr-F Et 3-Br 5482 Pr-F Et 4-Br 5483 Pr-F Et 2-I 5484 Pr-F Et 3-I 5485 Pr-F Et 4-I 5486 Pr-F Et 2-SnMe.sub.3 5487 Pr-F Et 3-SnMe.sub.3 5488 Pr-F Et 4-SnMe.sub.3 5489 Pr-F Et 2-Me 5490 Pr-F Et 3-Me 5491 Pr-F Et 4-Me 5492 Pr-F Et 2-OH 5493 Pr-F Et 3-OH 5494 Pr-F Et 4-OH 5495 Pr-F Et 2-OMe 5496 Pr-F Et 3-OMe 5497 Pr-F Et 4-OMe 5498 Pr-F Et 2-OMeF 5499 Pr-F Et 3-OMeF 5500 Pr-F Et 4-OMeF 5501 Pr-F Et 2-OCF.sub.3 5502 Pr-F Et 3-OCF.sub.3 5503 Pr-F Et 4-OCF.sub.3 5504 Pr-F Et 2-OEtF 5505 Pr-F Et 3-OEtF 5506 Pr-F Et 4-OEtF 5507 Pr-F Et 2-OPrF 5508 Pr-F Et 3-OPrF 5509 Pr-F Et 4-OPrF 5510 Pr-F Et 2-SH 5511 Pr-F Et 3-SH 5512 Pr-F Et 4-SH 5513 Pr-F Et 2-SMe 5514 Pr-F Et 3-SMe 5515 Pr-F Et 4-SMe 5516 Pr-F Et 2-SMeF 5517 Pr-F Et 3-SMeF 5518 Pr-F Et 4-SMeF 5519 Pr-F Et 2-SCF.sub.3 5520 Pr-F Et 3-SCF.sub.3 5521 Pr-F Et 4-SCF.sub.3 5522 Pr-F Et 2-SEtF 5523 Pr-F Et 3-SEtF 5524 Pr-F Et 4-SEtF 5525 Pr-F Et 2-SPrF 5526 Pr-F Et 3-SPrF 5527 Pr-F Et 4-SPrF 5528 Pr-F Et 2-OMe, 4-OMe 5529 Pr-F Et 2-Me, 5-OH 5530 Pr-F Et 2-Me, 5-OMe 5531 Pr-F Et 2-Me, 5-OMeF 5532 Pr-F Et 2-Me, 5-OEtF 5533 Pr-F Et 2-Me, 5-OPrF 5534 Pr-F Et 2-Me, 4-OH 5535 Pr-F Et 2-Me, 4-OMe 5536 Pr-F Et 2-Me, 4-OMeF 5537 Pr-F Et 2-Me, 4-OCF.sub.3 5538 Pr-F Et 2-Me, 4-OEtF 5539 Pr-F Et 2-Me, 4-OPrF 5540 Pr-F Et 2-OH, 4-Me 5541 Pr-F Et 2-OMe, 4-Me 5542 Pr-F Et 2-OMeF, 4-Me 5543 Pr-F Et 2-OCF.sub.3, 4-Me 5544 Pr-F Et 2-OEtF, 4-Me 5545 Pr-F Et 2-OPrF, 4-Me 5546 Pr-F Et 2-Cl, 4-OH 5547 Pr-F Et 2-Cl, 4-OMe 5548 Pr-F Et 2-Cl, 4-OMeF 5549 Pr-F Et 2-Cl, 4-OCF.sub.3 5550 Pr-F Et 2-Cl, 4-OEtF 5551 Pr-F Et 2-Cl, 4-OPrF 5552 Pr-F Et 2-F, 4-F 5553 Pr-F Et 2-Cl, 4-Cl 5554 Pr-F Et 2-Cl, 4-F 5555 Pr-F Et 2-Cl, 4-NO.sub.2 5556 Pr-F Et 2-Cl, 4-NH.sub.2 5557 Pr-F Et 2-Cl, 4-NHMe 5558 Pr-F Et 2-Cl, 4-NMe.sub.2 5559 Pr-F Et 2-Cl, 4-NMe.sub.3OTf 5560 Pr-F Et 2-Cl, 4-NMe.sub.3I 5561 Pr-F Et 2-Cl, 5-F 5562 Pr-F Et 2-Cl, 5-NO.sub.2 5563 Pr-F Et 2-Cl, 5-NH.sub.2 5564 Pr-F Et 2-Cl, 5-NHMe 5565 Pr-F Et 2-Cl, 5-NMe.sub.2 5566 Pr-F Et 2-Cl, 5-NMe.sub.3OTf 5567 Pr-F Et 2-Cl, 5-NMe.sub.3I 5568 Pr-F Et 2-F, 4-Cl 5569 Pr-F Et 2-NO.sub.2, 4-Cl 5570 Pr-F Et 2-NH.sub.2, 4-Cl 5571 Pr-F Et 2-NHMe, 4-Cl 5572 Pr-F Et 2-NMe.sub.2, 4-Cl 5573 Pr-F Et 2-NMe.sub.3OTf, 4-Cl 5574 Pr-F Et 2-NMe.sub.3I, 4-Cl 5575 Pr-F Et 2-F, 5-Cl 5576 Pr-F Et 2-NO.sub.2, 5-Cl 5577 Pr-F Et 2-NH.sub.2, 5-Cl 5578 Pr-F Et 2-NHMe, 5-Cl 5579 Pr-F Et 2-NMe.sub.2, 5-Cl 5580 Pr-F Et 2-NMe.sub.3OTF, 5-Cl 5581 Pr-F Et 2-NMe.sub.3I, 5-Cl 5582 Pr-F Et 2-Br, 4-F 5583 Pr-F Et 2-Br, 4-NO.sub.2 5584 Pr-F Et 2-Br, 4-NH.sub.2 5585 Pr-F Et 2-Br, 4-NHMe 5586 Pr-F Et 2-Br, 4-NMe.sub.2 5587 Pr-F Et 2-Br, 4-NMe.sub.3OTf 5588 Pr-F Et 2-Br, 4-NMe.sub.3I 5589 Pr-F Et 2-Br, 5-F 5590 Pr-F Et 2-Br, 5-NO.sub.2 5591 Pr-F Et 2-Br, 5-NH.sub.2 5592 Pr-F Et 2-Br, 5-NHMe 5593 Pr-F Et 2-Br, 5-NMe.sub.3 5594 Pr-F Et 2-Br, 5-NMe.sub.3OTf 5595 Pr-F Et 2-Br, 5-NMe.sub.3I 5596 Pr-F Et 2-F, 4-Br 5597 Pr-F Et 2-NO.sub.2, 4-Br 5598 Pr-F Et 2-NH.sub.2, 4-Br 5599 Pr-F Et 2-NHMe, 4-Br 5600 Pr-F Et 2-NMe.sub.3, 4-Br 5601 Pr-F Et 2-NMe.sub.3OTf, 4-Br 5602 Pr-F Et 2-NMe.sub.3I, 4-Br 5603 Pr-F Et 2-I, 4-F 5604 Pr-F Et 2-I, 4-NO.sub.2 5605 Pr-F Et 2-I, 4-NH.sub.2 5606 Pr-F Et 2-I, 4-NHMe 5607 Pr-F Et 2-I, 4-NMe.sub.2 5608 Pr-F Et 2-I, 4-NMe.sub.3OTf 5609 Pr-F Et 2-I, 4-NMe.sub.3I 5610 Pr-F Et 2-F, 4-I 5611 Pr-F Et 2-NO.sub.2, 4-I 5612 Pr-F Et 2-NH.sub.2, 4-I 5613 Pr-F Et 2-NHMe, 4-I 5614 Pr-F Et 2-NMe.sub.2, 4-I 5615 Pr-F Et 2-NMe.sub.3OTf, 4-I 5616 Pr-F Et 2-NMe.sub.3I, 4-I 5617 Pr-F Et 2-Me, 3-F 5618 Pr-F Et 2-Me, 3-NO.sub.2 5619 Pr-F Et 2-Me, 3-NH.sub.2 5620 Pr-F Et 2-Me, 3-NHMe 5621 Pr-F Et 2-Me, 3-NMe.sub.2 5622 Pr-F Et 2-Me, 3-NMe.sub.3OTf 5623 Pr-F Et 2-Me, 3-NMe.sub.3I 5624 Pr-F Et 2-Me, 4-F 5625 Pr-F Et 2-Me, 4-NO.sub.2 5626 Pr-F Et 2-Me, 4-NH.sub.2 5627 Pr-F Et 2-Me, 4-NHMe 5628 Pr-F Et 2-Me, 4-NMe.sub.2 5629 Pr-F Et 2-Me, 4-NMe.sub.3OTf 5630 Pr-F Et 2-Me, 4-NMe.sub.3I 5631 Pr-F Et 2-Me, 5-F 5632 Pr-F Et 2-Me, 5-NO.sub.2 5633 Pr-F Et 2-Me, 5-NH.sub.2 5634 Pr-F Et 2-Me, 5-NHMe 5635 Pr-F Et 2-Me, 5-NMe.sub.2 5636 Pr-F Et 2-Me, 5-NMe.sub.3OTf 5637 Pr-F Et 2-Me, 5-NMe.sub.3I 5638 Pr-F Et 2-F, 4-Me 5639 Pr-F Et 2-NO.sub.2, 4-Me 5640 Pr-F Et 2-NH.sub.2, 4-Me 5641 Pr-F Et 2-NHMe, 4-Me 5642 Pr-F Et 2-NMe.sub.2, 4-Me 5643 Pr-F Et 2-NMe.sub.3, 4-Me 5644 Pr-F Et 2-NMe.sub.3OTf, 4-Me 5645 Pr-F Et 2-NMe.sub.3I, 4-Me 5646 Pr-F Et 2-SnMe.sub.3, 4-F 5647 Pr-F Et 2-SnMe.sub.3, 5-F 5648 Pr-F Et 2-F, 4-SnMe.sub.3 5649 Pr-F Et 2-Br, 6-Cl, 4-F 5650 Pr-F Et 2-Br, 6-Cl, 4-NO.sub.2 5651 Pr-F Et 2-Br, 6-Cl, 4-NH.sub.2 5652 Pr-F Et 2-Br, 6-Cl, 4-NHMe 5653 Pr-F Et 2-Br, 6-Cl, 4-NMe.sub.2 5654 Pr-F Et 2-Br, 6-Cl, 4-NMe.sub.3OTf 5655 Pr-F Et 2-Br, 6-Cl, 4-NMe.sub.3I 5656 Pr-F Et 2-Me, 6-Cl, 4-F 5657 Pr-F Et 2-SnMe.sub.3, 6-Cl, 4-F 5658 Pr-F Et 2-Cl, 4-Me 5659 Pr-F Et 2-Cl, 4-Br 5660 Pr-F Et 2-Cl, 4-SnMe.sub.3 5661 Pr-F Et 2-Br, 4-Cl 5662 Pr-F Et 2-SnMe.sub.3, 4-Cl 5663 Pr-F Et 2-Me, 4-Cl 5664 Pr-F Et 2-Br, 4-Br 5665 Pr-F Et 2-Br, 4-Me 5666 Pr-F Et 2-Br, 4-SnMe.sub.3 5667 Pr-F Et 2-SnMe.sub.3, 4-Br 5668 Pr-F Et 2-Me, 4-Br 5669 Pr-F Et 2-Me, 4-SnMe.sub.3 5670 Pr-F Et 2-SnMe.sub.3, 4-Me 5671 Pr-F Et 2-Me, 4-Me 5672 Pr-F Et 2-Et, 4-Br 5673 Pr-F Et 2-Et, 4-SnMe.sub.3 5674 Pr-F Et 2-Et, 4-Me 5675 Pr-F Et 2-Me, 4-Me, 6-Me 5676 Pr-F Et 2-Me, 4-Br, 6-Me 5677 Pr-F Et 2-Me, 4-SnMe.sub.3, 6-Me 5678 Pr-F Et 2-Et, 6-Me 5679 Pr-F Et 2-Br, 4-i-Pr 5680 Pr-F Et 2-SnMe.sub.3, 4-i-Pr 5681 Pr-F Et 2-Me, 4-i-Pr 5682 Pr-F Et 2-Br, 4-Br, 6-Br 5683 Pr-F Et 2-Br, 4-Me, 6-Br 5684 Pr-F Et 2-Br, 4-SnMe.sub.3, 6-Br 5685 Pr-F Et 2-SnMe.sub.3, 4-Br, 6-Br 5686 Pr-F Et 2-Br, 4-Br, 6-Me 5687 Pr-F Et 2-Br, 4-CF.sub.3, 6-Br 5688 Pr-F Et 2-Br, 4-Br, 6-CF.sub.3 5689 Pr-F Et 2-CF.sub.3, 4-CF.sub.3 5690 Pr-F Et 2-Cl, 4-CF.sub.3 5691 Pr-F Et 2-CF.sub.3, 4-Cl 5692 Pr-F Et 2-Br, 4-CF.sub.3 5693 Pr-F Et 2-SnMe.sub.3, 4-CF.sub.3 5694 Pr-F Et 2-Me, 4-CF.sub.3 5695 Pr-F Et 2-CF.sub.3, 4-Br 5696 Pr-F Et 2-CF.sub.3, 4-SnMe.sub.3 5697 Pr-F Et 2-CF.sub.3, 4-Me 5698 Pr-F Et 2-Br, 4-OH 5699 Pr-F Et 2-Br, 4-OMe 5700 Pr-F Et 2-Br, 4-OMeF 5701 Pr-F Et 2-Br, 4-OCF.sub.3

5702 Pr-F Et 2-Br, 4-OEtF 5703 Pr-F Et 2-Br, 4-OPrF 5704 Pr-F Et 2-OH, 4-Br 5705 Pr-F Et 2-OMe, 4-Br 5706 Pr-F Et 2-OMeF, 4-Br 5707 Pr-F Et 2-OCF.sub.3, 4-Br 5708 Pr-F Et 2-OEtF, 4-Br 5709 Pr-F Et 2-OPrF, 4-Br 5710 Pr-F Et 2-I, 4-OH 5711 Pr-F Et 2-I, 4-OMe 5712 Pr-F Et 2-I, 4-OMeF 5713 Pr-F Et 2-I, 4-OCF.sub.3 5714 Pr-F Et 2-I, 4-OEtF 5715 Pr-F Et 2-I, 4-OPrF 5716 Pr-F Et 2-OH, 4-I 5717 Pr-F Et 2-OMe, 4-I 5718 Pr-F Et 2-OMeF, 4-I 5719 Pr-F Et 2-OCF.sub.3, 4-I 5720 Pr-F Et 2-OEtF, 4-I 5721 Pr-F Et 2-OPrF, 4-I 5722 Pr-F Et 2-SnMe.sub.3, 4-OH 5723 Pr-F Et 2-SnMe.sub.3, 4-OMe 5724 Pr-F Et 2-SnMe.sub.3, 4-OMeF 5725 Pr-F Et 2-SnMe.sub.3, 4-OCF.sub.3 5726 Pr-F Et 2-SnMe.sub.3, 4-OEtF 5727 Pr-F Et 2-SnMe.sub.3, 4-OPrF 5728 Pr-F Et 2-OH, 2-SnMe.sub.3 5729 Pr-F Et 2-OMe, 4-SnMe.sub.3 5730 Pr-F Et 2-OMeF, 4-SnMe.sub.3 5731 Pr-F Et 4-OCF.sub.3, 4-SnMe.sub.3 5732 Pr-F Et 2-OEtF, 4-SnMe.sub.3 5733 Pr-F Et 2-OPrF, 4-SnMe.sub.3 5734 Bu Et-F H 5735 Bu Et-F 2-t-Bu 5736 Bu Et-F 2-Br 5737 Bu Et-F 3-Br 5738 Bu Et-F 4-Br 5739 Bu Et-F 2-I 5740 Bu Et-F 3-I 5741 Bu Et-F 4-I 5742 Bu Et-F 2-SnMe.sub.3 5743 Bu Et-F 3-SnMe.sub.3 5744 Bu Et-F 4-SnMe.sub.3 5745 Bu Et-F 2-Me 5746 Bu Et-F 3-Me 5747 Bu Et-F 4-Me 5748 Bu Et-F 2-OH 5749 Bu Et-F 3-OH 5750 Bu Et-F 4-OH 5751 Bu Et-F 2-OMe 5752 Bu Et-F 3-OMe 5753 Bu Et-F 4-OMe 5754 Bu Et-F 2-OMeF 5755 Bu Et-F 3-OMeF 5756 Bu Et-F 4-OMeF 5757 Bu Et-F 2-OCF.sub.3 5758 Bu Et-F 3-OCF.sub.3 5759 Bu Et-F 4-OCF.sub.3 5760 Bu Et-F 2-OEtF 5761 Bu Et-F 3-OEtF 5762 Bu Et-F 4-OEtF 5763 Bu Et-F 2-OPrF 5764 Bu Et-F 3-OPrF 5765 Bu Et-F 4-OPrF 5766 Bu Et-F 2-SH 5767 Bu Et-F 3-SH 5768 Bu Et-F 4-SH 5769 Bu Et-F 2-SMe 5770 Bu Et-F 3-SMe 5771 Bu Et-F 4-SMe 5772 Bu Et-F 2-SMeF 5773 Bu Et-F 3-SMeF 5774 Bu Et-F 4-SMeF 5775 Bu Et-F 2-SCF.sub.3 5776 Bu Et-F 3-SCF.sub.3 5777 Bu Et-F 4-SCF.sub.3 5778 Bu Et-F 2-SEtF 5779 Bu Et-F 3-SEtF 5780 Bu Et-F 4-SEtF 5781 Bu Et-F 2-SPrF 5782 Bu Et-F 3-SPrF 5783 Bu Et-F 4-SPrF 5784 Bu Et-F 2-OMe, 4-OMe 5785 Bu Et-F 2-Me, 5-OH 5786 Bu Et-F 2-Me, 5-OMe 5787 Bu Et-F 2-Me, 5-OMeF 5788 Bu Et-F 2-Me, 5-OEtF 5789 Bu Et-F 2-Me, 5-OPrF 5790 Bu Et-F 2-Me, 4-OH 5791 Bu Et-F 2-Me, 4-OMe 5792 Bu Et-F 2-Me, 4-OMeF 5793 Bu Et-F 2-Me, 4-OCF.sub.3 5794 Bu Et-F 2-Me, 4-OEtF 5795 Bu Et-F 2-Me, 4-OPrF 5796 Bu Et-F 2-OH, 4-Me 5797 Bu Et-F 2-OMe, 4-Me 5798 Bu Et-F 2-OMeF, 4-Me 5799 Bu Et-F 2-OCF.sub.3, 4-Me 5800 Bu Et-F 2-OEtF, 4-Me 5801 Bu Et-F 2-OPrF, 4-Me 5802 Bu Et-F 2-Cl, 4-OH 5803 Bu Et-F 2-Cl, 4-OMe 5804 Bu Et-F 2-Cl, 4-OMeF 5805 Bu Et-F 2-Cl, 4-OCF.sub.3 5806 Bu Et-F 2-Cl, 4-OEtF 5807 Bu Et-F 2-Cl, 4-OPrF 5808 Bu Et-F 2-F, 4-F 5809 Bu Et-F 2-Cl, 4-Cl 5810 Bu Et-F 2-Cl, 4-F 5811 Bu Et-F 2-Cl, 4-NO.sub.2 5812 Bu Et-F 2-Cl, 4-NH.sub.2 5813 Bu Et-F 2-Cl, 4-NHMe 5814 Bu Et-F 2-Cl, 4-NMe.sub.2 5815 Bu Et-F 2-Cl, 4-NMe.sub.3OTf 5816 Bu Et-F 2-Cl, 4-NMe.sub.3I 5817 Bu Et-F 2-Cl, 5-F 5818 Bu Et-F 2-Cl, 5-NO.sub.2 5819 Bu Et-F 2-Cl, 5-NH.sub.2 5820 Bu Et-F 2-Cl, 5-NHMe 5821 Bu Et-F 2-Cl, 5-NMe.sub.2 5822 Bu Et-F 2-Cl, 5-NMe.sub.3OTf 5823 Bu Et-F 2-Cl, 5-NMe.sub.3I 5824 Bu Et-F 2-F, 4-Cl 5825 Bu Et-F 2-NO.sub.2, 4-Cl 5826 Bu Et-F 2-NH.sub.2, 4-Cl 5827 Bu Et-F 2-NHMe, 4-Cl 5828 Bu Et-F 2-NMe.sub.2, 4-Cl 5829 Bu Et-F 2-NMe.sub.3OTf, 4-Cl 5830 Bu Et-F 2-NMe.sub.3I, 4-Cl 5831 Bu Et-F 2-F, 5-Cl 5832 Bu Et-F 2-NO.sub.2, 5-Cl 5833 Bu Et-F 2-NH.sub.2, 5-Cl 5834 Bu Et-F 2-NHMe, 5-Cl 5835 Bu Et-F 2-NMe.sub.2, 5-Cl 5836 Bu Et-F 2-NMe.sub.3OTF, 5-Cl 5837 Bu Et-F 2-NMe.sub.3I, 5-Cl 5838 Bu Et-F 2-Br, 4-F 5839 Bu Et-F 2-Br, 4-NO.sub.2 5840 Bu Et-F 2-Br, 4-NH.sub.2 5841 Bu Et-F 2-Br, 4-NHMe 5842 Bu Et-F 2-Br, 4-NMe.sub.2 5843 Bu Et-F 2-Br, 4-NMe.sub.3OTf 5844 Bu Et-F 2-Br, 4-NMe.sub.3I 5845 Bu Et-F 2-Br, 5-F 5846 Bu Et-F 2-Br, 5-NO.sub.2 5847 Bu Et-F 2-Br, 5-NH.sub.2 5848 Bu Et-F 2-Br, 5-NHMe 5849 Bu Et-F 2-Br, 5-NMe.sub.3 5850 Bu Et-F 2-Br, 5-NMe.sub.3OTf 5851 Bu Et-F 2-Br, 5-NMe.sub.3I 5852 Bu Et-F 2-F, 4-Br 5853 Bu Et-F 2-NO.sub.2, 4-Br 5854 Bu Et-F 2-NH.sub.2, 4-Br 5855 Bu Et-F 2-NHMe, 4-Br 5856 Bu Et-F 2-NMe.sub.3, 4-Br 5857 Bu Et-F 2-NMe.sub.3OTf, 4-Br 5858 Bu Et-F 2-NMe.sub.3I, 4-Br 5859 Bu Et-F 2-I, 4-F 5860 Bu Et-F 2-I, 4-NO.sub.2 5861 Bu Et-F 2-I, 4-NH.sub.2 5862 Bu Et-F 2-I, 4-NHMe 5863 Bu Et-F 2-I, 4-NMe.sub.2 5864 Bu Et-F 2-I, 4-NMe.sub.3OTf 5865 Bu Et-F 2-I, 4-NMe.sub.3I 5866 Bu Et-F 2-F, 4-I 5867 Bu Et-F 2-NO.sub.2, 4-I 5868 Bu Et-F 2-NH.sub.2, 4-I 5869 Bu Et-F 2-NHMe, 4-I 5870 Bu Et-F 2-NMe.sub.2, 4-I 5871 Bu Et-F 2-NMe.sub.3OTf, 4-I 5872 Bu Et-F 2-NMe.sub.3I, 4-I 5873 Bu Et-F 2-Me, 3-F 5874 Bu Et-F 2-Me, 3-NO.sub.2 5875 Bu Et-F 2-Me, 3-NH.sub.2 5876 Bu Et-F 2-Me, 3-NHMe 5877 Bu Et-F 2-Me, 3-NMe.sub.2 5878 Bu Et-F 2-Me, 3-NMe.sub.3OTf 5879 Bu Et-F 2-Me, 3-NMe.sub.3I 5880 Bu Et-F 2-Me, 4-F 5881 Bu Et-F 2-Me, 4-NO.sub.2 5882 Bu Et-F 2-Me, 4-NH.sub.2 5883 Bu Et-F 2-Me, 4-NHMe 5884 Bu Et-F 2-Me, 4-NMe.sub.2 5885 Bu Et-F 2-Me, 4-NMe.sub.3OTf 5886 Bu Et-F 2-Me, 4-NMe.sub.3I 5887 Bu Et-F 2-Me, 5-F 5888 Bu Et-F 2-Me, 5-NO.sub.2 5889 Bu Et-F 2-Me, 5-NH.sub.2 5890 Bu Et-F 2-Me, 5-NHMe 5891 Bu Et-F 2-Me, 5-NMe.sub.2 5892 Bu Et-F 2-Me, 5-NMe.sub.3OTf 5893 Bu Et-F 2-Me, 5-NMe.sub.3I 5894 Bu Et-F 2-F, 4-Me 5895 Bu Et-F 2-NO.sub.2, 4-Me 5896 Bu Et-F 2-NH.sub.2, 4-Me 5897 Bu Et-F 2-NHMe, 4-Me 5898 Bu Et-F 2-NMe.sub.2, 4-Me 5899 Bu Et-F 2-NMe.sub.3, 4-Me 5900 Bu Et-F 2-NMe.sub.3OTf, 4-Me 5901 Bu Et-F 2-NMe.sub.3I, 4-Me 5902 Bu Et-F 2-SnMe.sub.3, 4-F 5903 Bu Et-F 2-SnMe.sub.3, 5-F 5904 Bu Et-F 2-F, 4-SnMe.sub.3 5905 Bu Et-F 2-Br, 6-Cl, 4-F 5906 Bu Et-F 2-Br, 6-Cl, 4-NO.sub.2 5907 Bu Et-F 2-Br, 6-Cl, 4-NH.sub.2 5908 Bu Et-F 2-Br, 6-Cl, 4-NHMe 5909 Bu Et-F 2-Br, 6-Cl, 4-NMe.sub.2 5910 Bu Et-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 5911 Bu Et-F 2-Br, 6-Cl, 4-NMe.sub.3I 5912 Bu Et-F 2-Me, 6-Cl, 4-F 5913 Bu Et-F 2-SnMe.sub.3, 6-Cl, 4-F 5914 Bu Et-F 2-Cl, 4-Me 5915 Bu Et-F 2-Cl, 4-Br 5916 Bu Et-F 2-Cl, 4-SnMe.sub.3 5917 Bu Et-F 2-Br, 4-Cl 5918 Bu Et-F 2-SnMe.sub.3, 4-Cl 5919 Bu Et-F 2-Me, 4-Cl 5920 Bu Et-F 2-Br, 4-Br 5921 Bu Et-F 2-Br, 4-Me 5922 Bu Et-F 2-Br, 4-SnMe.sub.3 5923 Bu Et-F 2-SnMe.sub.3, 4-Br 5924 Bu Et-F 2-Me, 4-Br 5925 Bu Et-F 2-Me, 4-SnMe.sub.3 5926 Bu Et-F 2-SnMe.sub.3, 4-Me 5927 Bu Et-F 2-Me, 4-Me 5928 Bu Et-F 2-Et, 4-Br 5929 Bu Et-F 2-Et, 4-SnMe.sub.3 5930 Bu Et-F 2-Et, 4-Me 5931 Bu Et-F 2-Me, 4-Me, 6-Me 5932 Bu Et-F 2-Me, 4-Br, 6-Me 5933 Bu Et-F 2-Me, 4-SnMe.sub.3, 6-Me 5934 Bu Et-F 2-Et, 6-Me 5935 Bu Et-F 2-Br, 4-i-Pr 5936 Bu Et-F 2-SnMe.sub.3, 4-i-Pr 5937 Bu Et-F 2-Me, 4-i-Pr 5938 Bu Et-F 2-Br, 4-Br, 6-Br 5939 Bu Et-F 2-Br, 4-Me, 6-Br 5940 Bu Et-F 2-Br, 4-SnMe.sub.3, 6-Br 5941 Bu Et-F 2-SnMe.sub.3, 4-Br, 6-Br 5942 Bu Et-F 2-Br, 4-Br, 6-Me 5943 Bu Et-F 2-Br, 4-CF.sub.3, 6-Br 5944 Bu Et-F 2-Br, 4-Br, 6-CF.sub.3 5945 Bu Et-F 2-CF.sub.3, 4-CF.sub.3 5946 Bu Et-F 2-Cl, 4-CF.sub.3 5947 Bu Et-F 2-CF.sub.3, 4-Cl 5948 Bu Et-F 2-Br, 4-CF.sub.3 5949 Bu Et-F 2-SnMe.sub.3, 4-CF.sub.3 5950 Bu Et-F 2-Me, 4-CF.sub.3 5951 Bu Et-F 2-CF.sub.3, 4-Br 5952 Bu Et-F 2-CF.sub.3, 4-SnMe.sub.3

5953 Bu Et-F 2-CF.sub.3, 4-Me 5954 Bu Et-F 2-Br, 4-OH 5955 Bu Et-F 2-Br, 4-OMe 5956 Bu Et-F 2-Br, 4-OMeF 5957 Bu Et-F 2-Br, 4-OCF.sub.3 5958 Bu Et-F 2-Br, 4-OEtF 5959 Bu Et-F 2-Br, 4-OPrF 5960 Bu Et-F 2-OH, 4-Br 5961 Bu Et-F 2-OMe, 4-Br 5962 Bu Et-F 2-OMeF, 4-Br 5963 Bu Et-F 2-OCF.sub.3, 4-Br 5964 Bu Et-F 2-OEtF, 4-Br 5965 Bu Et-F 2-OPrF, 4-Br 5966 Bu Et-F 2-I, 4-OH 5967 Bu Et-F 2-I, 4-OMe 5968 Bu Et-F 2-I, 4-OMeF 5969 Bu Et-F 2-I, 4-OCF.sub.3 5970 Bu Et-F 2-I, 4-OEtF 5971 Bu Et-F 2-I, 4-OPrF 5972 Bu Et-F 2-OH, 4-I 5973 Bu Et-F 2-OMe, 4-I 5974 Bu Et-F 2-OMeF, 4-I 5975 Bu Et-F 2-OCF.sub.3, 4-I 5976 Bu Et-F 2-OEtF, 4-I 5977 Bu Et-F 2-OPrF, 4-I 5978 Bu Et-F 2-SnMe.sub.3, 4-OH 5979 Bu Et-F 2-SnMe.sub.3, 4-OMe 5980 Bu Et-F 2-SnMe.sub.3, 4-OMeF 5981 Bu Et-F 2-SnMe.sub.3, 4-OCF.sub.3 5982 Bu Et-F 2-SnMe.sub.3, 4-OEtF 5983 Bu Et-F 2-SnMe.sub.3, 4-OPrF 5984 Bu Et-F 2-OH, 2-SnMe.sub.3 5985 Bu Et-F 2-OMe, 4-SnMe.sub.3 5986 Bu Et-F 2-OMeF, 4-SnMe.sub.3 5987 Bu Et-F 4-OCF.sub.3, 4-SnMe.sub.3 5988 Bu Et-F 2-OEtF, 4-SnMe.sub.3 5989 Bu Et-F 2-OPrF, 4-SnMe.sub.3 5990 Bu-F Et H 5991 Bu-F Et 2-t-Bu 5992 Bu-F Et 2-Br 5993 Bu-F Et 3-Br 5994 Bu-F Et 4-Br 5995 Bu-F Et 2-I 5996 Bu-F Et 3-I 5997 Bu-F Et 4-I 5998 Bu-F Et 2-SnMe.sub.3 5999 Bu-F Et 3-SnMe.sub.3 6000 Bu-F Et 4-SnMe.sub.3 6001 Bu-F Et 2-Me 6002 Bu-F Et 3-Me 6003 Bu-F Et 4-Me 6004 Bu-F Et 2-OH 6005 Bu-F Et 3-OH 6006 Bu-F Et 4-OH 6007 Bu-F Et 2-OMe 6008 Bu-F Et 3-OMe 6009 Bu-F Et 4-OMe 6010 Bu-F Et 2-OMeF 6011 Bu-F Et 3-OMeF 6012 Bu-F Et 4-OMeF 6013 Bu-F Et 2-OCF.sub.3 6014 Bu-F Et 3-OCF.sub.3 6015 Bu-F Et 4-OCF.sub.3 6016 Bu-F Et 2-OEtF 6017 Bu-F Et 3-OEtF 6018 Bu-F Et 4-OEtF 6019 Bu-F Et 2-OPrF 6020 Bu-F Et 3-OPrF 6021 Bu-F Et 4-OPrF 6022 Bu-F Et 2-SH 6023 Bu-F Et 3-SH 6024 Bu-F Et 4-SH 6025 Bu-F Et 2-SMe 6026 Bu-F Et 3-SMe 6027 Bu-F Et 4-SMe 6028 Bu-F Et 2-SMeF 6029 Bu-F Et 3-SMeF 6030 Bu-F Et 4-SMeF 6031 Bu-F Et 2-SCF.sub.3 6032 Bu-F Et 3-SCF.sub.3 6033 Bu-F Et 4-SCF.sub.3 6034 Bu-F Et 2-SEtF 6035 Bu-F Et 3-SEtF 6036 Bu-F Et 4-SEtF 6037 Bu-F Et 2-SPrF 6038 Bu-F Et 3-SPrF 6039 Bu-F Et 4-SPrF 6040 Bu-F Et 2-OMe, 4-OMe 6041 Bu-F Et 2-Me, 5-OH 6042 Bu-F Et 2-Me, 5-OMe 6043 Bu-F Et 2-Me, 5-OMeF 6044 Bu-F Et 2-Me, 5-OEtF 6045 Bu-F Et 2-Me, 5-OPrF 6046 Bu-F Et 2-Me, 4-OH 6047 Bu-F Et 2-Me, 4-OMe 6048 Bu-F Et 2-Me, 4-OMeF 6049 Bu-F Et 2-Me, 4-OCF.sub.3 6050 Bu-F Et 2-Me, 4-OEtF 6051 Bu-F Et 2-Me, 4-OPrF 6052 Bu-F Et 2-OH, 4-Me 6053 Bu-F Et 2-OMe, 4-Me 6054 Bu-F Et 2-OMeF, 4-Me 6055 Bu-F Et 2-OCF.sub.3, 4-Me 6056 Bu-F Et 2-OEtF, 4-Me 6057 Bu-F Et 2-OPrF, 4-Me 6058 Bu-F Et 2-Cl, 4-OH 6059 Bu-F Et 2-Cl, 4-OMe 6060 Bu-F Et 2-Cl, 4-OMeF 6061 Bu-F Et 2-Cl, 4-OCF.sub.3 6062 Bu-F Et 2-Cl, 4-OEtF 6063 Bu-F Et 2-Cl, 4-OPrF 6064 Bu-F Et 2-F, 4-F 6065 Bu-F Et 2-Cl, 4-Cl 6066 Bu-F Et 2-Cl, 4-F 6067 Bu-F Et 2-Cl, 4-NO.sub.2 6068 Bu-F Et 2-Cl, 4-NH.sub.2 6069 Bu-F Et 2-Cl, 4-NHMe 6070 Bu-F Et 2-Cl, 4-NMe.sub.2 6071 Bu-F Et 2-Cl, 4-NMe.sub.3OTf 6072 Bu-F Et 2-Cl, 4-NMe.sub.3I 6073 Bu-F Et 2-Cl, 5-F 6074 Bu-F Et 2-Cl, 5-NO.sub.2 6075 Bu-F Et 2-Cl, 5-NH.sub.2 6076 Bu-F Et 2-Cl, 5-NHMe 6077 Bu-F Et 2-Cl, 5-NMe.sub.2 6078 Bu-F Et 2-Cl, 5-NMe.sub.3OTf 6079 Bu-F Et 2-Cl, 5-NMe.sub.3I 6080 Bu-F Et 2-F, 4-Cl 6081 Bu-F Et 2-NO.sub.2, 4-Cl 6082 Bu-F Et 2-NH.sub.2, 4-Cl 6083 Bu-F Et 2-NHMe, 4-Cl 6084 Bu-F Et 2-NMe.sub.2, 4-Cl 6085 Bu-F Et 2-NMe.sub.3OTf, 4-Cl 6086 Bu-F Et 2-NMe.sub.3I, 4-Cl 6087 Bu-F Et 2-F, 5-Cl 6088 Bu-F Et 2-NO.sub.2, 5-Cl 6089 Bu-F Et 2-NH.sub.2, 5-Cl 6090 Bu-F Et 2-NHMe, 5-Cl 6091 Bu-F Et 2-NMe.sub.2, 5-Cl 6092 Bu-F Et 2-NMe.sub.3OTF, 5-Cl 6093 Bu-F Et 2-NMe.sub.3I, 5-Cl 6094 Bu-F Et 2-Br, 4-F 6095 Bu-F Et 2-Br, 4-NO.sub.2 6096 Bu-F Et 2-Br, 4-NH.sub.2 6097 Bu-F Et 2-Br, 4-NHMe 6098 Bu-F Et 2-Br, 4-NMe.sub.2 6099 Bu-F Et 2-Br, 4-NMe.sub.3OTf 6100 Bu-F Et 2-Br, 4-NMe.sub.3I 6101 Bu-F Et 2-Br, 5-F 6102 Bu-F Et 2-Br, 5-NO.sub.2 6103 Bu-F Et 2-Br, 5-NH.sub.2 6104 Bu-F Et 2-Br, 5-NHMe 6105 Bu-F Et 2-Br, 5-NMe.sub.3 6106 Bu-F Et 2-Br, 5-NMe.sub.3OTf 6107 Bu-F Et 2-Br, 5-NMe.sub.3I 6108 Bu-F Et 2-F, 4-Br 6109 Bu-F Et 2-NO.sub.2, 4-Br 6110 Bu-F Et 2-NH.sub.2, 4-Br 6111 Bu-F Et 2-NHMe, 4-Br 6112 Bu-F Et 2-NMe.sub.3, 4-Br 6113 Bu-F Et 2-NMe.sub.3OTf, 4-Br 6114 Bu-F Et 2-NMe.sub.3I, 4-Br 6115 Bu-F Et 2-I, 4-F 6116 Bu-F Et 2-I, 4-NO.sub.2 6117 Bu-F Et 2-I, 4-NH.sub.2 6118 Bu-F Et 2-I, 4-NHMe 6119 Bu-F Et 2-I, 4-NMe.sub.2 6120 Bu-F Et 2-I, 4-NMe.sub.3OTf 6121 Bu-F Et 2-I, 4-NMe.sub.3I 6122 Bu-F Et 2-F, 4-I 6123 Bu-F Et 2-NO.sub.2, 4-I 6124 Bu-F Et 2-NH.sub.2, 4-I 6125 Bu-F Et 2-NHMe, 4-I 6126 Bu-F Et 2-NMe.sub.2, 4-I 6127 Bu-F Et 2-NMe.sub.3OTf, 4-I 6128 Bu-F Et 2-NMe.sub.3I, 4-I 6129 Bu-F Et 2-Me, 3-F 6130 Bu-F Et 2-Me, 3-NO.sub.2 6131 Bu-F Et 2-Me, 3-NH.sub.2 6132 Bu-F Et 2-Me, 3-NHMe 6133 Bu-F Et 2-Me, 3-NMe.sub.2 6134 Bu-F Et 2-Me, 3-NMe.sub.3OTf 6135 Bu-F Et 2-Me, 3-NMe.sub.3I 6136 Bu-F Et 2-Me, 4-F 6137 Bu-F Et 2-Me, 4-NO.sub.2 6138 Bu-F Et 2-Me, 4-NH.sub.2 6139 Bu-F Et 2-Me, 4-NHMe 6140 Bu-F Et 2-Me, 4-NMe.sub.2 6141 Bu-F Et 2-Me, 4-NMe.sub.3OTf 6142 Bu-F Et 2-Me, 4-NMe.sub.3I 6143 Bu-F Et 2-Me, 5-F 6144 Bu-F Et 2-Me, 5-NO.sub.2 6145 Bu-F Et 2-Me, 5-NH.sub.2 6146 Bu-F Et 2-Me, 5-NHMe 6147 Bu-F Et 2-Me, 5-NMe.sub.2 6148 Bu-F Et 2-Me, 5-NMe.sub.3OTf 6149 Bu-F Et 2-Me, 5-NMe.sub.3I 6150 Bu-F Et 2-F, 4-Me 6151 Bu-F Et 2-NO.sub.2, 4-Me 6152 Bu-F Et 2-NH.sub.2, 4-Me 6153 Bu-F Et 2-NHMe, 4-Me 6154 Bu-F Et 2-NMe.sub.2, 4-Me 6155 Bu-F Et 2-NMe.sub.3, 4-Me 6156 Bu-F Et 2-NMe.sub.3OTf, 4-Me 6157 Bu-F Et 2-NMe.sub.3I, 4-Me 6158 Bu-F Et 2-SnMe.sub.3, 4-F 6159 Bu-F Et 2-SnMe.sub.3, 5-F 6160 Bu-F Et 2-F, 4-SnMe.sub.3 6161 Bu-F Et 2-Br, 6-Cl, 4-F 6162 Bu-F Et 2-Br, 6-Cl, 4-NO.sub.2 6163 Bu-F Et 2-Br, 6-Cl, 4-NH.sub.2 6164 Bu-F Et 2-Br, 6-Cl, 4-NHMe 6165 Bu-F Et 2-Br, 6-Cl, 4-NMe.sub.2 6166 Bu-F Et 2-Br, 6-Cl, 4-NMe.sub.3OTf 6167 Bu-F Et 2-Br, 6-Cl, 4-NMe.sub.3I 6168 Bu-F Et 2-Me, 6-Cl, 4-F 6169 Bu-F Et 2-SnMe.sub.3, 6-Cl, 4-F 6170 Bu-F Et 2-Cl, 4-Me 6171 Bu-F Et 2-Cl, 4-Br 6172 Bu-F Et 2-Cl, 4-SnMe.sub.3 6173 Bu-F Et 2-Br, 4-Cl 6174 Bu-F Et 2-SnMe.sub.3, 4-Cl 6175 Bu-F Et 2-Me, 4-Cl 6176 Bu-F Et 2-Br, 4-Br 6177 Bu-F Et 2-Br, 4-Me 6178 Bu-F Et 2-Br, 4-SnMe.sub.3 6179 Bu-F Et 2-SnMe.sub.3, 4-Br 6180 Bu-F Et 2-Me, 4-Br 6181 Bu-F Et 2-Me, 4-SnMe.sub.3 6182 Bu-F Et 2-SnMe.sub.3, 4-Me 6183 Bu-F Et 2-Me, 4-Me 6184 Bu-F Et 2-Et, 4-Br 6185 Bu-F Et 2-Et, 4-SnMe.sub.3 6186 Bu-F Et 2-Et, 4-Me 6187 Bu-F Et 2-Me, 4-Me, 6-Me 6188 Bu-F Et 2-Me, 4-Br, 6-Me 6189 Bu-F Et 2-Me, 4-SnMe.sub.3, 6-Me 6190 Bu-F Et 2-Et, 6-Me 6191 Bu-F Et 2-Br, 4-i-Pr 6192 Bu-F Et 2-SnMe.sub.3, 4-i-Pr 6193 Bu-F Et 2-Me, 4-i-Pr 6194 Bu-F Et 2-Br, 4-Br, 6-Br 6195 Bu-F Et 2-Br, 4-Me, 6-Br 6196 Bu-F Et 2-Br, 4-SnMe.sub.3, 6-Br 6197 Bu-F Et 2-SnMe.sub.3, 4-Br, 6-Br 6198 Bu-F Et 2-Br, 4-Br, 6-Me 6199 Bu-F Et 2-Br, 4-CF.sub.3, 6-Br 6200 Bu-F Et 2-Br, 4-Br, 6-CF.sub.3 6201 Bu-F Et 2-CF.sub.3, 4-CF.sub.3 6202 Bu-F Et 2-Cl, 4-CF.sub.3 6203 Bu-F Et 2-CF.sub.3, 4-Cl

6204 Bu-F Et 2-Br, 4-CF.sub.3 6205 Bu-F Et 2-SnMe.sub.3, 4-CF.sub.3 6206 Bu-F Et 2-Me, 4-CF.sub.3 6207 Bu-F Et 2-CF.sub.3, 4-Br 6208 Bu-F Et 2-CF.sub.3, 4-SnMe.sub.3 6209 Bu-F Et 2-CF.sub.3, 4-Me 6210 Bu-F Et 2-Br, 4-OH 6211 Bu-F Et 2-Br, 4-OMe 6212 Bu-F Et 2-Br, 4-OMeF 6213 Bu-F Et 2-Br, 4-OCF.sub.3 6214 Bu-F Et 2-Br, 4-OEtF 6215 Bu-F Et 2-Br, 4-OPrF 6216 Bu-F Et 2-OH, 4-Br 6217 Bu-F Et 2-OMe, 4-Br 6218 Bu-F Et 2-OMeF, 4-Br 6219 Bu-F Et 2-OCF.sub.3, 4-Br 6220 Bu-F Et 2-OEtF, 4-Br 6221 Bu-F Et 2-OPrF, 4-Br 6222 Bu-F Et 2-I, 4-OH 6223 Bu-F Et 2-I, 4-OMe 6224 Bu-F Et 2-I, 4-OMeF 6225 Bu-F Et 2-I, 4-OCF.sub.3 6226 Bu-F Et 2-I, 4-OEtF 6227 Bu-F Et 2-I, 4-OPrF 6228 Bu-F Et 2-OH, 4-I 6229 Bu-F Et 2-OMe, 4-I 6230 Bu-F Et 2-OMeF, 4-I 6231 Bu-F Et 2-OCF.sub.3, 4-I 6232 Bu-F Et 2-OEtF, 4-I 6233 Bu-F Et 2-OPrF, 4-I 6234 Bu-F Et 2-SnMe.sub.3, 4-OH 6235 Bu-F Et 2-SnMe.sub.3, 4-OMe 6236 Bu-F Et 2-SnMe.sub.3, 4-OMeF 6237 Bu-F Et 2-SnMe.sub.3, 4-OCF.sub.3 6238 Bu-F Et 2-SnMe.sub.3, 4-OEtF 6239 Bu-F Et 2-SnMe.sub.3, 4-OPrF 6240 Bu-F Et 2-OH, 2-SnMe.sub.3 6241 Bu-F Et 2-OMe, 4-SnMe.sub.3 6242 Bu-F Et 2-OMeF, 4-SnMe.sub.3 6243 Bu-F Et 4-OCF.sub.3, 4-SnMe.sub.3 6244 Bu-F Et 2-OEtF, 4-SnMe.sub.3 6245 Bu-F Et 2-OPrF, 4-SnMe.sub.3 6246 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H 6247 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-t-Bu 6248 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br 6249 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Br 6250 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br 6251 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I 6252 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-I 6253 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-I 6254 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3 6255 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SnMe.sub.3 6256 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SnMe.sub.3 6257 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me 6258 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Me 6259 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me 6260 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH 6261 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OH 6262 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH 6263 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe 6264 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMe 6265 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe 6266 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF 6267 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMeF 6268 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF 6269 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 6270 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OCF.sub.3 6271 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 6272 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF 6273 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OEtF 6274 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF 6275 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF 6276 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OPrF 6277 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF 6278 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SH 6279 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SH 6280 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SH 6281 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SMe 6282 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SMe 6283 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SMe 6284 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SMeF 6285 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SMeF 6286 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SMeF 6287 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SCF.sub.3 6288 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SCF.sub.3 6289 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SCF.sub.3 6290 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SEtF 6291 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SEtF 6292 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SEtF 6293 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SPrF 6294 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SPrF 6295 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SPrF 6296 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-OMe 6297 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OH 6298 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OMe 6299 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OMeF 6300 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OEtF 6301 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-OPrF 6302 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OH 6303 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OMe 6304 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OMeF 6305 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OCF.sub.3 6306 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OEtF 6307 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-OPrF 6308 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-Me 6309 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-Me 6310 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-Me 6311 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-Me 6312 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-Me 6313 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-Me 6314 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OH 6315 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OMe 6316 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OMeF 6317 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OCF.sub.3 6318 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OEtF 6319 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-OPrF 6320 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-F 6321 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Cl 6322 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-F 6323 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NO.sub.2 6324 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NH.sub.2 6325 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NHMe 6326 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.2 6327 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.3OTf 6328 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-NMe.sub.3I 6329 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-F 6330 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NO.sub.2 6331 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NH.sub.2 6332 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NHMe 6333 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.2 6334 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.3OTf 6335 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 5-NMe.sub.3I 6336 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Cl 6337 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Cl 6338 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Cl 6339 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Cl 6340 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-Cl 6341 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-Cl 6342 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Cl 6343 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 5-Cl 6344 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 5-Cl 6345 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 5-Cl 6346 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 5-Cl 6347 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 5-Cl 6348 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTF, 5-Cl 6349 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 5-Cl 6350 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-F 6351 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NO.sub.2 6352 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NH.sub.2 6353 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NHMe 6354 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NMe.sub.2 6355 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NMe.sub.3OTf 6356 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-NMe.sub.3I 6357 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-F 6358 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NO.sub.2 6359 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NH.sub.2 6360 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NHMe 6361 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NMe.sub.3 6362 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NMe.sub.3OTf 6363 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 5-NMe.sub.3I 6364 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Br 6365 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Br 6366 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Br 6367 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Br 6368 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3, 4-Br 6369 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-Br 6370 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Br 6371 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-F 6372 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NO.sub.2 6373 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NH.sub.2 6374 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NHMe 6375 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.2 6376 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.3OTf 6377 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-NMe.sub.3I 6378 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-I 6379 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-I 6380 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-I 6381 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-I 6382 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-I 6383 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-I 6384 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-I 6385 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-F 6386 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NO.sub.2 6387 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NH.sub.2 6388 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NHMe 6389 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NMe.sub.2 6390 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NMe.sub.3OTf 6391 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 3-NMe.sub.3I 6392 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-F 6393 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NO.sub.2 6394 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NH.sub.2 6395 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NHMe 6396 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NMe.sub.2 6397 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NMe.sub.3OTf 6398 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-NMe.sub.3I 6399 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-F 6400 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NO.sub.2 6401 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NH.sub.2 6402 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NHMe 6403 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NMe.sub.2 6404 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NMe.sub.3OTf 6405 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 5-NMe.sub.3I 6406 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-Me 6407 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NO.sub.2, 4-Me 6408 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NH.sub.2, 4-Me 6409 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NHMe, 4-Me 6410 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.2, 4-Me 6411 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3, 4-Me 6412 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3OTf, 4-Me 6413 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-NMe.sub.3I, 4-Me 6414 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-F 6415 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 5-F 6416 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F, 4-SnMe.sub.3 6417 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-F 6418 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NO.sub.2 6419 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NH.sub.2 6420 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NHMe 6421 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NMe.sub.2 6422 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NMe.sub.3OTf 6423 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6-Cl, 4-NMe.sub.3I 6424 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 6-Cl, 4-F 6425 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 6-Cl, 4-F 6426 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Me 6427 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Br 6428 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-SnMe.sub.3 6429 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Cl 6430 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Cl 6431 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Cl 6432 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br 6433 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me 6434 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-SnMe.sub.3 6435 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Br 6436 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Br 6437 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-SnMe.sub.3 6438 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Me 6439 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Me 6440 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-Br 6441 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-SnMe.sub.3 6442 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 4-Me 6443 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Me, 6-Me 6444 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-Br, 6-Me 6445 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-SnMe.sub.3, 6-Me 6446 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et, 6-Me 6447 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-i-Pr 6448 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-i-Pr 6449 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-i-Pr 6450 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-Br 6451 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Me, 6-Br 6452 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-SnMe.sub.3, 6-Br 6453 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-Br, 6-Br 6454 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-Me

6455 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3, 6-Br 6456 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br, 6-CF.sub.3 6457 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-CF.sub.3 6458 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-CF.sub.3 6459 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Cl 6460 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-CF.sub.3 6461 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-CF.sub.3 6462 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, 4-CF.sub.3 6463 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Br 6464 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-SnMe.sub.3 6465 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4-Me 6466 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OH 6467 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OMe 6468 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OMeF 6469 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OCF.sub.3 6470 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OEtF 6471 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-OPrF 6472 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-Br 6473 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-Br 6474 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-Br 6475 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-Br 6476 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-Br 6477 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-Br 6478 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OH 6479 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OMe 6480 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OMeF 6481 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OCF.sub.3 6482 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OEtF 6483 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-I, 4-OPrF 6484 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 4-I 6485 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-I 6486 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-I 6487 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3, 4-I 6488 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-I 6489 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-I 6490 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OH 6491 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OMe 6492 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OMeF 6493 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OCF.sub.3 6494 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OEtF 6495 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3, 4-OPrF 6496 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH, 2-SnMe.sub.3 6497 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, 4-SnMe.sub.3 6498 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF, 4-SnMe.sub.3 6499 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3, 4-SnMe.sub.3 6500 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF, 4-SnMe.sub.3 6501 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF, 4-SnMe.sub.3 6502 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H 6503 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-t-Bu 6504 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br 6505 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Br 6506 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br 6507 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I 6508 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-I 6509 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-I 6510 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3 6511 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SnMe.sub.3 6512 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SnMe.sub.3 6513 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me 6514 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Me 6515 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me 6516 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH 6517 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OH 6518 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH 6519 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe 6520 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMe 6521 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe 6522 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF 6523 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMeF 6524 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF 6525 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 6526 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OCF.sub.3 6527 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 6528 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF 6529 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OEtF 6530 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF 6531 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF 6532 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OPrF 6533 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF 6534 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SH 6535 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SH 6536 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SH 6537 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SMe 6538 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SMe 6539 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SMe 6540 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SMeF 6541 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SMeF 6542 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SMeF 6543 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SCF.sub.3 6544 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SCF.sub.3 6545 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SCF.sub.3 6546 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SEtF 6547 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SEtF 6548 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SEtF 6549 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SPrF 6550 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SPrF 6551 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SPrF 6552 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-OMe 6553 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OH 6554 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OMe 6555 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OMeF 6556 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OEtF 6557 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-OPrF 6558 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OH 6559 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OMe 6560 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OMeF 6561 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OCF.sub.3 6562 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OEtF 6563 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-OPrF 6564 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-Me 6565 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-Me 6566 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-Me 6567 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-Me 6568 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-Me 6569 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-Me 6570 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OH 6571 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OMe 6572 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OMeF 6573 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OCF.sub.3 6574 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OEtF 6575 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-OPrF 6576 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-F 6577 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Cl 6578 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-F 6579 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NO.sub.2 6580 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NH.sub.2 6581 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NHMe 6582 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.2 6583 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.3OTf 6584 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-NMe.sub.3I 6585 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-F 6586 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NO.sub.2 6587 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NH.sub.2 6588 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NHMe 6589 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.2 6590 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.3OTf 6591 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 5-NMe.sub.3I 6592 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Cl 6593 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Cl 6594 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Cl 6595 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Cl 6596 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-Cl 6597 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-Cl 6598 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Cl 6599 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 5-Cl 6600 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 5-Cl 6601 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 5-Cl 6602 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 5-Cl 6603 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 5-Cl 6604 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTF, 5-Cl 6605 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 5-Cl 6606 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-F 6607 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NO.sub.2 6608 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NH.sub.2 6609 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NHMe 6610 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NMe.sub.2 6611 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NMe.sub.3OTf 6612 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-NMe.sub.3I 6613 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-F 6614 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NO.sub.2 6615 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NH.sub.2 6616 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NHMe 6617 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NMe.sub.3 6618 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NMe.sub.3OTf 6619 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 5-NMe.sub.3I 6620 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Br 6621 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Br 6622 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Br 6623 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Br 6624 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3, 4-Br 6625 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-Br 6626 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Br 6627 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-F 6628 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NO.sub.2 6629 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NH.sub.2 6630 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NHMe 6631 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.2 6632 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.3OTf 6633 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-NMe.sub.3I 6634 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-I 6635 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-I 6636 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-I 6637 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-I 6638 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-I 6639 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-I 6640 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-I 6641 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-F 6642 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NO.sub.2 6643 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NH.sub.2 6644 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NHMe 6645 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NMe.sub.2 6646 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NMe.sub.3OTf 6647 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 3-NMe.sub.3I 6648 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-F 6649 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NO.sub.2 6650 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NH.sub.2 6651 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NHMe 6652 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NMe.sub.2 6653 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NMe.sub.3OTf 6654 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-NMe.sub.3I 6655 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-F 6656 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NO.sub.2 6657 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NH.sub.2 6658 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NHMe 6659 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NMe.sub.2 6660 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NMe.sub.3OTf 6661 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 5-NMe.sub.3I 6662 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-Me 6663 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NO.sub.2, 4-Me 6664 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NH.sub.2, 4-Me 6665 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NHMe, 4-Me 6666 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.2, 4-Me 6667 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3, 4-Me 6668 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3OTf, 4-Me 6669 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-NMe.sub.3I, 4-Me 6670 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-F 6671 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 5-F 6672 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F, 4-SnMe.sub.3 6673 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-F 6674 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NO.sub.2 6675 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NH.sub.2 6676 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NHMe 6677 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NMe.sub.2 6678 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NMe.sub.3OTf 6679 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6-Cl, 4-NMe.sub.3I 6680 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 6-Cl, 4-F 6681 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 6-Cl, 4-F 6682 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Me 6683 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Br 6684 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-SnMe.sub.3 6685 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Cl 6686 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Cl 6687 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Cl 6688 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br 6689 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me 6690 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-SnMe.sub.3 6691 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Br 6692 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Br 6693 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-SnMe.sub.3 6694 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Me 6695 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Me 6696 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-Br 6697 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-SnMe.sub.3 6698 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 4-Me 6699 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Me, 6-Me 6700 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-Br, 6-Me 6701 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-SnMe.sub.3, 6-Me 6702 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et, 6-Me 6703 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-i-Pr 6704 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-i-Pr 6705 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-i-Pr

6706 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-Br 6707 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Me, 6-Br 6708 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-SnMe.sub.3, 6-Br 6709 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-Br, 6-Br 6710 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-Me 6711 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3, 6-Br 6712 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br, 6-CF.sub.3 6713 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-CF.sub.3 6714 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-CF.sub.3 6715 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Cl 6716 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-CF.sub.3 6717 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-CF.sub.3 6718 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, 4-CF.sub.3 6719 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Br 6720 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-SnMe.sub.3 6721 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4-Me 6722 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OH 6723 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OMe 6724 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OMeF 6725 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OCF.sub.3 6726 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OEtF 6727 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-OPrF 6728 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-Br 6729 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-Br 6730 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-Br 6731 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-Br 6732 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-Br 6733 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-Br 6734 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OH 6735 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OMe 6736 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OMeF 6737 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OCF.sub.3 6738 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OEtF 6739 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-I, 4-OPrF 6740 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 4-I 6741 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-I 6742 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-I 6743 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3, 4-I 6744 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-I 6745 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-I 6746 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OH 6747 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OMe 6748 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OMeF 6749 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OCF.sub.3 6750 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OEtF 6751 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3, 4-OPrF 6752 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH, 2-SnMe.sub.3 6753 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, 4-SnMe.sub.3 6754 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF, 4-SnMe.sub.3 6755 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3, 4-SnMe.sub.3 6756 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF, 4-SnMe.sub.3 6757 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF, 4-SnMe.sub.3 6758 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F H 6759 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-t-Bu 6760 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br 6761 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-Br 6762 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Br 6763 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I 6764 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-I 6765 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-I 6766 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3 6767 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SnMe.sub.3 6768 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SnMe.sub.3 6769 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me 6770 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-Me 6771 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-Me 6772 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH 6773 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OH 6774 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OH 6775 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe 6776 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OMe 6777 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMe 6778 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF 6779 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OMeF 6780 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OMeF 6781 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3 6782 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OCF.sub.3 6783 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3 6784 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF 6785 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OEtF 6786 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OEtF 6787 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF 6788 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-OPrF 6789 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OPrF 6790 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SH 6791 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SH 6792 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SH 6793 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SMe 6794 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SMe 6795 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SMe 6796 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SMeF 6797 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SMeF 6798 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SMeF 6799 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SCF.sub.3 6800 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SCF.sub.3 6801 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SCF.sub.3 6802 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SEtF 6803 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SEtF 6804 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SEtF 6805 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SPrF 6806 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 3-SPrF 6807 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-SPrF 6808 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe, 4-OMe 6809 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-OH 6810 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-OMe 6811 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-OMeF 6812 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-OEtF 6813 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-OPrF 6814 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OH 6815 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OMe 6816 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OMeF 6817 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OCF.sub.3 6818 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OEtF 6819 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-OPrF 6820 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH, 4-Me 6821 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe, 4-Me 6822 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF, 4-Me 6823 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3, 4-Me 6824 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF, 4-Me 6825 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF, 4-Me 6826 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OH 6827 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OMe 6828 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OMeF 6829 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OCF.sub.3 6830 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OEtF 6831 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-OPrF 6832 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-F 6833 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-Cl 6834 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-F 6835 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NO.sub.2 6836 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NH.sub.2 6837 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NHMe 6838 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NMe.sub.2 6839 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NMe.sub.3OTf 6840 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-NMe.sub.3I 6841 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-F 6842 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NO.sub.2 6843 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NH.sub.2 6844 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NHMe 6845 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NMe.sub.2 6846 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NMe.sub.3OTf 6847 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 5-NMe.sub.3I 6848 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-Cl 6849 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NO.sub.2, 4-Cl 6850 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NH.sub.2, 4-Cl 6851 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NHMe, 4-Cl 6852 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.2, 4-Cl 6853 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3OTf, 4-Cl 6854 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3I, 4-Cl 6855 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 5-Cl 6856 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NO.sub.2, 5-Cl 6857 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NH.sub.2, 5-Cl 6858 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NHMe, 5-Cl 6859 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.2, 5-Cl 6860 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3OTF, 5-Cl 6861 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3I, 5-Cl 6862 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-F 6863 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NO.sub.2 6864 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NH.sub.2 6865 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NHMe 6866 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NMe.sub.2 6867 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NMe.sub.3OTf 6868 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-NMe.sub.3I 6869 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-F 6870 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NO.sub.2 6871 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NH.sub.2 6872 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NHMe 6873 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NMe.sub.3 6874 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NMe.sub.3OTf 6875 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 5-NMe.sub.3I 6876 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-Br 6877 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NO.sub.2, 4-Br 6878 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NH.sub.2, 4-Br 6879 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NHMe, 4-Br 6880 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3, 4-Br 6881 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3OTf, 4-Br 6882 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3I, 4-Br 6883 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-F 6884 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NO.sub.2 6885 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NH.sub.2 6886 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NHMe 6887 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NMe.sub.2 6888 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NMe.sub.3OTf 6889 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-NMe.sub.3I 6890 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-I 6891 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NO.sub.2, 4-I 6892 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NH.sub.2, 4-I 6893 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NHMe, 4-I 6894 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.2, 4-I 6895 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3OTf, 4-I 6896 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3I, 4-I 6897 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-F 6898 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NO.sub.2 6899 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NH.sub.2 6900 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NHMe 6901 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NMe.sub.2 6902 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NMe.sub.3OTf 6903 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 3-NMe.sub.3I 6904 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-F 6905 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NO.sub.2 6906 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NH.sub.2 6907 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NHMe 6908 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NMe.sub.2 6909 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NMe.sub.3OTf 6910 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-NMe.sub.3I 6911 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-F 6912 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NO.sub.2 6913 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NH.sub.2 6914 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NHMe 6915 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NMe.sub.2 6916 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NMe.sub.3OTf 6917 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 5-NMe.sub.3I 6918 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-Me 6919 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NO.sub.2, 4-Me 6920 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NH.sub.2, 4-Me 6921 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NHMe, 4-Me 6922 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.2, 4-Me 6923 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3, 4-Me 6924 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3OTf, 4-Me 6925 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-NMe.sub.3I, 4-Me 6926 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-F 6927 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 5-F 6928 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-F, 4-SnMe.sub.3 6929 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-F 6930 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NO.sub.2 6931 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NH.sub.2 6932 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NHMe 6933 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NMe.sub.2 6934 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 6935 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 6-Cl, 4-NMe.sub.3I 6936 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 6-Cl, 4-F 6937 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 6-Cl, 4-F 6938 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-Me 6939 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-Br 6940 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-SnMe.sub.3 6941 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Cl 6942 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-Cl 6943 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-Cl 6944 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br 6945 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me 6946 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-SnMe.sub.3 6947 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-Br 6948 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-Br 6949 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-SnMe.sub.3 6950 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-Me 6951 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-Me 6952 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et, 4-Br 6953 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et, 4-SnMe.sub.3 6954 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et, 4-Me 6955 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-Me, 6-Me 6956 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-Br, 6-Me

6957 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-SnMe.sub.3, 6-Me 6958 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Et, 6-Me 6959 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-i-Pr 6960 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-i-Pr 6961 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-i-Pr 6962 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br, 6-Br 6963 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Me, 6-Br 6964 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-SnMe.sub.3, 6-Br 6965 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-Br, 6-Br 6966 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br, 6-Me 6967 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3, 6-Br 6968 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-Br, 6-CF.sub.3 6969 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-CF.sub.3 6970 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Cl, 4-CF.sub.3 6971 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Cl 6972 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-CF.sub.3 6973 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-CF.sub.3 6974 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Me, 4-CF.sub.3 6975 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Br 6976 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-SnMe.sub.3 6977 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-CF.sub.3, 4-Me 6978 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OH 6979 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OMe 6980 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OMeF 6981 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OCF.sub.3 6982 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OEtF 6983 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-Br, 4-OPrF 6984 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH, 4-Br 6985 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe, 4-Br 6986 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF, 4-Br 6987 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3, 4-Br 6988 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF, 4-Br 6989 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF, 4-Br 6990 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OH 6991 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OMe 6992 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OMeF 6993 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OCF.sub.3 6994 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OEtF 6995 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-I, 4-OPrF 6996 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH, 4-I 6997 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe, 4-I 6998 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF, 4-I 6999 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OCF.sub.3, 4-I 7000 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF, 4-I 7001 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF, 4-I 7002 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OH 7003 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OMe 7004 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OMeF 7005 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OCF.sub.3 7006 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OEtF 7007 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-SnMe.sub.3, 4-OPrF 7008 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OH, 2-SnMe.sub.3 7009 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMe, 4-SnMe.sub.3 7010 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OMeF, 4-SnMe.sub.3 7011 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 4-OCF.sub.3, 4-SnMe.sub.3 7012 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OEtF, 4-SnMe.sub.3 7013 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et-F 2-OPrF, 4-SnMe.sub.3

TABLE-US-00021 TABLE 6 Substituent list for compounds of general structure XI. XI ##STR00093## Compound # R.sup.1 = R.sup.2 = R.sup.4 = X.sup.2 = 7014 Bu Et H H 7015 Bu Et H SnMe.sub.3 7016 Bu Et H Br 7017 Bu Et H I 7018 Bu Et 4-F H 7019 Bu Et 4-F SnMe.sub.3 7020 Bu Et 4-F Br 7021 Bu Et 4-F I 7022 Bu Et 5-F H 7023 Bu Et 5-F SnMe.sub.3 7024 Bu Et 5-F Br 7025 Bu Et 5-F I 7026 Bu Et 4-Cl H 7027 Bu Et 4-Cl SnMe.sub.3 7028 Bu Et 4-Cl Br 7029 Bu Et 4-Cl I 7030 Bu Et 4-Br H 7031 Bu Et 4-Br SnMe.sub.3 7032 Bu Et 4-Br Br 7033 Bu Et 4-Br I 7034 Bu Et 4-Me H 7035 Bu Et 4-Me SnMe.sub.3 7036 Bu Et 4-Me Br 7037 Bu Et 4-Me I 7038 Bu Et 4-CF.sub.3 H 7039 Bu Et 4-CF.sub.3 SnMe.sub.3 7040 Bu Et 4-CF.sub.3 Br 7041 Bu Et 4-CF.sub.3 I 7042 Bu Et 4-OH H 7043 Bu Et 4-OH SnMe.sub.3 7044 Bu Et 4-OH Br 7045 Bu Et 4-OH I 7046 Bu Et 4-OMe H 7047 Bu Et 4-OMe SnMe.sub.3 7048 Bu Et 4-OMe Br 7049 Bu Et 4-OMe I 7050 Bu Et 4-OMeF H 7051 Bu Et 4-OMeF SnMe.sub.3 7052 Bu Et 4-OMeF Br 7053 Bu Et 4-OMeF I 7054 Bu Et 4-OCF.sub.3 H 7055 Bu Et 4-OCF.sub.3 SnMe.sub.3 7056 Bu Et 4-OCF.sub.3 Br 7057 Bu Et 4-OCF.sub.3 I 7058 Bu Et 4-OEtF H 7059 Bu Et 4-OEtF SnMe.sub.3 7060 Bu Et 4-OEtF Br 7061 Bu Et 4-OEtF I 7062 Bu Et 4-OPrF H 7063 Bu Et 4-OPrF SnMe.sub.3 7064 Bu Et 4-OPrF Br 7065 Bu Et 4-OPrF I 7066 Bu Et 4-i-Pr H 7067 Bu Et 4-i-Pr SnMe.sub.3 7068 Bu Et 4-i-Pr Br 7069 Bu Et 4-i-Pr I 7070 Bu Et 2-Br, 4- H CF.sub.3 7071 Bu Et 2-Br, 4- SnMe.sub.3 CF.sub.3 7072 Bu Et 2-Br, 4- Br CF.sub.3 7073 Bu Et 2-Br, 4- I CF.sub.3 7074 Bu Et 2-CF.sub.3, 4- H Br 7075 Bu Et 2-CF.sub.3, 4- SnMe.sub.3 Br 7076 Bu Et 2-CF.sub.3, 4- Br Br 7077 Bu Et 2-CF.sub.3, 4- I Br 7078 Bu Et 2-Br, 4-Br H 7079 Bu Et 2-Br, 4-Br SnMe.sub.3 7080 Bu Et 2-Br, 4-Br Br 7081 Bu Et 2-Br, 4-Br I 7082 Bu Et 2-Br, 4- H Me 7083 Bu Et 2-Br, 4- SnMe.sub.3 Me 7084 Bu Et 2-Br, 4- Br Me 7085 Bu Et 2-Br, 4- I Me 7086 Pr Pr H H 7087 Pr Pr H SnMe.sub.3 7088 Pr Pr H Br 7089 Pr Pr H I 7090 Pr Pr 4-F H 7091 Pr Pr 4-F SnMe.sub.3 7092 Pr Pr 4-F Br 7093 Pr Pr 4-F I 7094 Pr Pr 5-F H 7095 Pr Pr 5-F SnMe.sub.3 7096 Pr Pr 5-F Br 7097 Pr Pr 5-F I 7098 Pr Pr 4-Cl H 7099 Pr Pr 4-Cl SnMe.sub.3 7100 Pr Pr 4-Cl Br 7101 Pr Pr 4-Cl I 7102 Pr Pr 4-Br H 7103 Pr Pr 4-Br SnMe.sub.3 7104 Pr Pr 4-Br Br 7105 Pr Pr 4-Br I 7106 Pr Pr 4-Me H 7107 Pr Pr 4-Me SnMe.sub.3 7108 Pr Pr 4-Me Br 7109 Pr Pr 4-Me I 7110 Pr Pr 4-CF.sub.3 H 7111 Pr Pr 4-CF.sub.3 SnMe.sub.3 7112 Pr Pr 4-CF.sub.3 Br 7113 Pr Pr 4-CF.sub.3 I 7114 Pr Pr 4-OH H 7115 Pr Pr 4-OH SnMe.sub.3 7116 Pr Pr 4-OH Br 7117 Pr Pr 4-OH I 7118 Pr Pr 4-OMe H 7119 Pr Pr 4-OMe SnMe.sub.3 7120 Pr Pr 4-OMe Br 7121 Pr Pr 4-OMe I 7122 Pr Pr 4-OMeF H 7123 Pr Pr 4-OMeF SnMe.sub.3 7124 Pr Pr 4-OMeF Br 7125 Pr Pr 4-OMeF I 7126 Pr Pr 4-OCF.sub.3 H 7127 Pr Pr 4-OCF.sub.3 SnMe.sub.3 7128 Pr Pr 4-OCF.sub.3 Br 7129 Pr Pr 4-OCF.sub.3 I 7130 Pr Pr 4-OEtF H 7131 Pr Pr 4-OEtF SnMe.sub.3 7132 Pr Pr 4-OEtF Br 7133 Pr Pr 4-OEtF I 7134 Pr Pr 4-OPrF H 7135 Pr Pr 4-OPrF SnMe.sub.3 7136 Pr Pr 4-OPrF Br 7137 Pr Pr 4-OPrF I 7138 Pr Pr 4-i-Pr H 7139 Pr Pr 4-i-Pr SnMe.sub.3 7140 Pr Pr 4-i-Pr Br 7141 Pr Pr 4-i-Pr I 7142 Pr Pr 2-Br, 4- H CF.sub.3 7143 Pr Pr 2-Br, 4- SnMe.sub.3 CF.sub.3 7144 Pr Pr 2-Br, 4- Br CF.sub.3 7145 Pr Pr 2-Br, 4- I CF.sub.3 7146 Pr Pr 2-CF.sub.3, 4- H Br 7147 Pr Pr 2-CF.sub.3, 4- SnMe.sub.3 Br 7148 Pr Pr 2-CF.sub.3, 4- Br Br 7149 Pr Pr 2-CF.sub.3, 4- I Br 7150 Pr Pr 2-Br, 4-Br H 7151 Pr Pr 2-Br, 4-Br SnMe.sub.3 7152 Pr Pr 2-Br, 4-Br Br 7153 Pr Pr 2-Br, 4-Br I 7154 Pr Pr 2-Br, 4- H Me 7155 Pr Pr 2-Br, 4- SnMe.sub.3 Me 7156 Pr Pr 2-Br, 4- Br Me 7157 Pr Pr 2-Br, 4- I Me 7158 Pr Pr--F H H 7159 Pr Pr--F H SnMe.sub.3 7160 Pr Pr--F H Br 7161 Pr Pr--F H I 7162 Pr Pr--F 4-F H 7163 Pr Pr--F 4-F SnMe.sub.3 7164 Pr Pr--F 4-F Br 7165 Pr Pr--F 4-F I 7166 Pr Pr--F 5-F H 7167 Pr Pr--F 5-F SnMe.sub.3 7168 Pr Pr--F 5-F Br 7169 Pr Pr--F 5-F I 7170 Pr Pr--F 4-Cl H 7171 Pr Pr--F 4-Cl SnMe.sub.3 7172 Pr Pr--F 4-Cl Br 7173 Pr Pr--F 4-Cl I 7174 Pr Pr--F 4-Br H 7175 Pr Pr--F 4-Br SnMe.sub.3 7176 Pr Pr--F 4-Br Br 7177 Pr Pr--F 4-Br I 7178 Pr Pr--F 4-Me H 7179 Pr Pr--F 4-Me SnMe.sub.3 7180 Pr Pr--F 4-Me Br 7181 Pr Pr--F 4-Me I 7182 Pr Pr--F 4-CF.sub.3 H 7183 Pr Pr--F 4-CF.sub.3 SnMe.sub.3 7184 Pr Pr--F 4-CF.sub.3 Br 7185 Pr Pr--F 4-CF.sub.3 I 7186 Pr Pr--F 4-OH H 7187 Pr Pr--F 4-OH SnMe.sub.3 7188 Pr Pr--F 4-OH Br 7189 Pr Pr--F 4-OH I 7190 Pr Pr--F 4-OMe H 7191 Pr Pr--F 4-OMe SnMe.sub.3 7192 Pr Pr--F 4-OMe Br 7193 Pr Pr--F 4-OMe I 7194 Pr Pr--F 4-OMeF H 7195 Pr Pr--F 4-OMeF SnMe.sub.3 7196 Pr Pr--F 4-OMeF Br 7197 Pr Pr--F 4-OMeF I 7198 Pr Pr--F 4-OCF.sub.3 H 7199 Pr Pr--F 4-OCF.sub.3 SnMe.sub.3 7200 Pr Pr--F 4-OCF.sub.3 Br 7201 Pr Pr--F 4-OCF.sub.3 I 7202 Pr Pr--F 4-OEtF H 7203 Pr Pr--F 4-OEtF SnMe.sub.3 7204 Pr Pr--F 4-OEtF Br 7205 Pr Pr--F 4-OEtF I 7206 Pr Pr--F 4-OPrF H 7207 Pr Pr--F 4-OPrF SnMe.sub.3 7208 Pr Pr--F 4-OPrF Br 7209 Pr Pr--F 4-OPrF I 7210 Pr Pr--F 4-i-Pr H 7211 Pr Pr--F 4-i-Pr SnMe.sub.3 7212 Pr Pr--F 4-i-Pr Br 7213 Pr Pr--F 4-i-Pr I 7214 Pr Pr--F 2-Br, 4- H CF.sub.3 7215 Pr Pr--F 2-Br, 4- SnMe.sub.3 CF.sub.3 7216 Pr Pr--F 2-Br, 4- Br CF.sub.3 7217 Pr Pr--F 2-Br, 4- I CF.sub.3 7218 Pr Pr--F 2-CF.sub.3, 4- H Br 7219 Pr Pr--F 2-CF.sub.3, 4- SnMe.sub.3 Br 7220 Pr Pr--F 2-CF.sub.3, 4- Br Br 7221 Pr Pr--F 2-CF.sub.3, 4- I Br 7222 Pr Pr--F 2-Br, 4-Br H

7223 Pr Pr--F 2-Br, 4-Br SnMe.sub.3 7224 Pr Pr--F 2-Br, 4-Br Br 7225 Pr Pr--F 2-Br, 4-Br I 7226 Pr Pr--F 2-Br, 4- H Me 7227 Pr Pr--F 2-Br, 4- SnMe.sub.3 Me 7228 Pr Pr--F 2-Br, 4- Br Me 7229 Pr Pr--F 2-Br, 4- I Me 7230 Pr Et--F H H 7231 Pr Et--F H SnMe.sub.3 7232 Pr Et--F H Br 7233 Pr Et--F H I 7234 Pr Et--F 4-F H 7235 Pr Et--F 4-F SnMe.sub.3 7236 Pr Et--F 4-F Br 7237 Pr Et--F 4-F I 7238 Pr Et--F 5-F H 7239 Pr Et--F 5-F SnMe.sub.3 7240 Pr Et--F 5-F Br 7241 Pr Et--F 5-F I 7242 Pr Et--F 4-Cl H 7243 Pr Et--F 4-Cl SnMe.sub.3 7244 Pr Et--F 4-Cl Br 7245 Pr Et--F 4-Cl I 7246 Pr Et--F 4-Br H 7247 Pr Et--F 4-Br SnMe.sub.3 7248 Pr Et--F 4-Br Br 7249 Pr Et--F 4-Br I 7250 Pr Et--F 4-Me H 7251 Pr Et--F 4-Me SnMe.sub.3 7252 Pr Et--F 4-Me Br 7253 Pr Et--F 4-Me I 7254 Pr Et--F 4-CF.sub.3 H 7255 Pr Et--F 4-CF.sub.3 SnMe.sub.3 7256 Pr Et--F 4-CF.sub.3 Br 7257 Pr Et--F 4-CF.sub.3 I 7258 Pr Et--F 4-OH H 7259 Pr Et--F 4-OH SnMe.sub.3 7260 Pr Et--F 4-OH Br 7261 Pr Et--F 4-OH I 7262 Pr Et--F 4-OMe H 7263 Pr Et--F 4-OMe SnMe.sub.3 7264 Pr Et--F 4-OMe Br 7265 Pr Et--F 4-OMe I 7266 Pr Et--F 4-OMeF H 7267 Pr Et--F 4-OMeF SnMe.sub.3 7268 Pr Et--F 4-OMeF Br 7269 Pr Et--F 4-OMeF I 7270 Pr Et--F 4-OCF.sub.3 H 7271 Pr Et--F 4-OCF.sub.3 SnMe.sub.3 7272 Pr Et--F 4-OCF.sub.3 Br 7273 Pr Et--F 4-OCF.sub.3 I 7274 Pr Et--F 4-OEtF H 7275 Pr Et--F 4-OEtF SnMe.sub.3 7276 Pr Et--F 4-OEtF Br 7277 Pr Et--F 4-OEtF I 7278 Pr Et--F 4-OPrF H 7279 Pr Et--F 4-OPrF SnMe.sub.3 7280 Pr Et--F 4-OPrF Br 7281 Pr Et--F 4-OPrF I 7282 Pr Et--F 4-i-Pr H 7283 Pr Et--F 4-i-Pr SnMe.sub.3 7284 Pr Et--F 4-i-Pr Br 7285 Pr Et--F 4-i-Pr I 7286 Pr Et--F 2-Br, 4- H CF.sub.3 7287 Pr Et--F 2-Br, 4- SnMe.sub.3 CF.sub.3 7288 Pr Et--F 2-Br, 4- Br CF.sub.3 7289 Pr Et--F 2-Br, 4- I CF.sub.3 7290 Pr Et--F 2-CF.sub.3, 4- H Br 7291 Pr Et--F 2-CF.sub.3, 4- SnMe.sub.3 Br 7292 Pr Et--F 2-CF.sub.3, 4- Br Br 7293 Pr Et--F 2-CF.sub.3, 4- I Br 7294 Pr Et--F 2-Br, 4-Br H 7295 Pr Et--F 2-Br, 4-Br SnMe.sub.3 7296 Pr Et--F 2-Br, 4-Br Br 7297 Pr Et--F 2-Br, 4-Br I 7298 Pr Et--F 2-Br, 4- H Me 7299 Pr Et--F 2-Br, 4- SnMe.sub.3 Me 7300 Pr Et--F 2-Br, 4- Br Me 7301 Pr Et--F 2-Br, 4- I Me 7302 Pr--F Et H H 7303 Pr--F Et H SnMe.sub.3 7304 Pr--F Et H Br 7305 Pr--F Et H I 7306 Pr--F Et 4-F H 7307 Pr--F Et 4-F SnMe.sub.3 7308 Pr--F Et 4-F Br 7309 Pr--F Et 4-F I 7310 Pr--F Et 5-F H 7311 Pr--F Et 5-F SnMe.sub.3 7312 Pr--F Et 5-F Br 7313 Pr--F Et 5-F I 7314 Pr--F Et 4-Cl H 7315 Pr--F Et 4-Cl SnMe.sub.3 7316 Pr--F Et 4-Cl Br 7317 Pr--F Et 4-Cl I 7318 Pr--F Et 4-Br H 7319 Pr--F Et 4-Br SnMe.sub.3 7320 Pr--F Et 4-Br Br 7321 Pr--F Et 4-Br I 7322 Pr--F Et 4-Me H 7323 Pr--F Et 4-Me SnMe.sub.3 7324 Pr--F Et 4-Me Br 7325 Pr--F Et 4-Me I 7326 Pr--F Et 4-CF.sub.3 H 7327 Pr--F Et 4-CF.sub.3 SnMe.sub.3 7328 Pr--F Et 4-CF.sub.3 Br 7329 Pr--F Et 4-CF.sub.3 I 7330 Pr--F Et 4-OH H 7331 Pr--F Et 4-OH SnMe.sub.3 7332 Pr--F Et 4-OH Br 7333 Pr--F Et 4-OH I 7334 Pr--F Et 4-OMe H 7335 Pr--F Et 4-OMe SnMe.sub.3 7336 Pr--F Et 4-OMe Br 7337 Pr--F Et 4-OMe I 7338 Pr--F Et 4-OMeF H 7339 Pr--F Et 4-OMeF SnMe.sub.3 7340 Pr--F Et 4-OMeF Br 7341 Pr--F Et 4-OMeF I 7342 Pr--F Et 4-OCF.sub.3 H 7343 Pr--F Et 4-OCF.sub.3 SnMe.sub.3 7344 Pr--F Et 4-OCF.sub.3 Br 7345 Pr--F Et 4-OCF.sub.3 I 7346 Pr--F Et 4-OEtF H 7347 Pr--F Et 4-OEtF SnMe.sub.3 7348 Pr--F Et 4-OEtF Br 7349 Pr--F Et 4-OEtF I 7350 Pr--F Et 4-OPrF H 7351 Pr--F Et 4-OPrF SnMe.sub.3 7352 Pr--F Et 4-OPrF Br 7353 Pr--F Et 4-OPrF I 7354 Pr--F Et 4-i-Pr H 7355 Pr--F Et 4-i-Pr SnMe.sub.3 7356 Pr--F Et 4-i-Pr Br 7357 Pr--F Et 4-i-Pr I 7358 Pr--F Et 2-Br, 4- H CF.sub.3 7359 Pr--F Et 2-Br, 4- SnMe.sub.3 CF.sub.3 7360 Pr--F Et 2-Br, 4- Br CF.sub.3 7361 Pr--F Et 2-Br, 4- I CF.sub.3 7362 Pr--F Et 2-CF.sub.3, 4- H Br 7363 Pr--F Et 2-CF.sub.3, 4- SnMe.sub.3 Br 7364 Pr--F Et 2-CF.sub.3, 4- Br Br 7365 Pr--F Et 2-CF.sub.3, 4- I Br 7366 Pr--F Et 2-Br, 4-Br H 7367 Pr--F Et 2-Br, 4-Br SnMe.sub.3 7368 Pr--F Et 2-Br, 4-Br Br 7369 Pr--F Et 2-Br, 4-Br I 7370 Pr--F Et 2-Br, 4- H Me 7371 Pr--F Et 2-Br, 4- SnMe.sub.3 Me 7372 Pr--F Et 2-Br, 4- Br Me 7373 Pr--F Et 2-Br, 4- I Me 7374 Bu Et--F H H 7375 Bu Et--F H SnMe.sub.3 7376 Bu Et--F H Br 7377 Bu Et--F H I 7378 Bu Et--F 4-F H 7379 Bu Et--F 4-F SnMe.sub.3 7380 Bu Et--F 4-F Br 7381 Bu Et--F 4-F I 7382 Bu Et--F 5-F H 7383 Bu Et--F 5-F SnMe.sub.3 7384 Bu Et--F 5-F Br 7385 Bu Et--F 5-F I 7386 Bu Et--F 4-Cl H 7387 Bu Et--F 4-Cl SnMe.sub.3 7388 Bu Et--F 4-Cl Br 7389 Bu Et--F 4-Cl I 7390 Bu Et--F 4-Br H 7391 Bu Et--F 4-Br SnMe.sub.3 7392 Bu Et--F 4-Br Br 7393 Bu Et--F 4-Br I 7394 Bu Et--F 4-Me H 7395 Bu Et--F 4-Me SnMe.sub.3 7396 Bu Et--F 4-Me Br 7397 Bu Et--F 4-Me I 7398 Bu Et--F 4-CF.sub.3 H 7399 Bu Et--F 4-CF.sub.3 SnMe.sub.3 7400 Bu Et--F 4-CF.sub.3 Br 7401 Bu Et--F 4-CF.sub.3 I 7402 Bu Et--F 4-OH H 7403 Bu Et--F 4-OH SnMe.sub.3 7404 Bu Et--F 4-OH Br 7405 Bu Et--F 4-OH I 7406 Bu Et--F 4-OMe H 7407 Bu Et--F 4-OMe SnMe.sub.3 7408 Bu Et--F 4-OMe Br 7409 Bu Et--F 4-OMe I 7410 Bu Et--F 4-OMeF H 7411 Bu Et--F 4-OMeF SnMe.sub.3 7412 Bu Et--F 4-OMeF Br 7413 Bu Et--F 4-OMeF I 7414 Bu Et--F 4-OCF.sub.3 H 7415 Bu Et--F 4-OCF.sub.3 SnMe.sub.3 7416 Bu Et--F 4-OCF.sub.3 Br 7417 Bu Et--F 4-OCF.sub.3 I 7418 Bu Et--F 4-OEtF H 7419 Bu Et--F 4-OEtF SnMe.sub.3 7420 Bu Et--F 4-OEtF Br 7421 Bu Et--F 4-OEtF I 7422 Bu Et--F 4-OPrF H 7423 Bu Et--F 4-OPrF SnMe.sub.3 7424 Bu Et--F 4-OPrF Br 7425 Bu Et--F 4-OPrF I 7426 Bu Et--F 4-i-Pr H 7427 Bu Et--F 4-i-Pr SnMe.sub.3 7428 Bu Et--F 4-i-Pr Br 7429 Bu Et--F 4-i-Pr I 7430 Bu Et--F 2-Br, 4- H CF.sub.3 7431 Bu Et--F 2-Br, 4- SnMe.sub.3 CF.sub.3 7432 Bu Et--F 2-Br, 4- Br CF.sub.3 7433 Bu Et--F 2-Br, 4- I CF.sub.3 7434 Bu Et--F 2-CF.sub.3, 4- H Br 7435 Bu Et--F 2-CF.sub.3, 4- SnMe.sub.3 Br 7436 Bu Et--F 2-CF.sub.3, 4- Br Br 7437 Bu Et--F 2-CF.sub.3, 4- I Br

7438 Bu Et--F 2-Br, 4-Br H 7439 Bu Et--F 2-Br, 4-Br SnMe.sub.3 7440 Bu Et--F 2-Br, 4-Br Br 7441 Bu Et--F 2-Br, 4-Br I 7442 Bu Et--F 2-Br, 4- H Me 7443 Bu Et--F 2-Br, 4- SnMe.sub.3 Me 7444 Bu Et--F 2-Br, 4- Br Me 7445 Bu Et--F 2-Br, 4- I Me 7446 Bu--F Et H H 7447 Bu--F Et H SnMe.sub.3 7448 Bu--F Et H Br 7449 Bu--F Et H I 7450 Bu--F Et 4-F H 7451 Bu--F Et 4-F SnMe.sub.3 7452 Bu--F Et 4-F Br 7453 Bu--F Et 4-F I 7454 Bu--F Et 5-F H 7455 Bu--F Et 5-F SnMe.sub.3 7456 Bu--F Et 5-F Br 7457 Bu--F Et 5-F I 7458 Bu--F Et 4-Cl H 7459 Bu--F Et 4-Cl SnMe.sub.3 7460 Bu--F Et 4-Cl Br 7461 Bu--F Et 4-Cl I 7462 Bu--F Et 4-Br H 7463 Bu--F Et 4-Br SnMe.sub.3 7464 Bu--F Et 4-Br Br 7465 Bu--F Et 4-Br I 7466 Bu--F Et 4-Me H 7467 Bu--F Et 4-Me SnMe.sub.3 7468 Bu--F Et 4-Me Br 7469 Bu--F Et 4-Me I 7470 Bu--F Et 4-CF.sub.3 H 7471 Bu--F Et 4-CF.sub.3 SnMe.sub.3 7472 Bu--F Et 4-CF.sub.3 Br 7473 Bu--F Et 4-CF.sub.3 I 7474 Bu--F Et 4-OH H 7475 Bu--F Et 4-OH SnMe.sub.3 7476 Bu--F Et 4-OH Br 7477 Bu--F Et 4-OH I 7478 Bu--F Et 4-OMe H 7479 Bu--F Et 4-OMe SnMe.sub.3 7480 Bu--F Et 4-OMe Br 7481 Bu--F Et 4-OMe I 7482 Bu--F Et 4-OMeF H 7483 Bu--F Et 4-OMeF SnMe.sub.3 7484 Bu--F Et 4-OMeF Br 7485 Bu--F Et 4-OMeF I 7486 Bu--F Et 4-OCF.sub.3 H 7487 Bu--F Et 4-OCF.sub.3 SnMe.sub.3 7488 Bu--F Et 4-OCF.sub.3 Br 7489 Bu--F Et 4-OCF.sub.3 I 7490 Bu--F Et 4-OEtF H 7191 Bu--F Et 4-OEtF SnMe.sub.3 7492 Bu--F Et 4-OEtF Br 7493 Bu--F Et 4-OEtF I 7494 Bu--F Et 4-OPrF H 7495 Bu--F Et 4-OPrF SnMe.sub.3 7496 Bu--F Et 4-OPrF Br 7497 Bu--F Et 4-OPrF I 7498 Bu--F Et 4-i-Pr H 7499 Bu--F Et 4-i-Pr SnMe.sub.3 7500 Bu--F Et 4-i-Pr Br 7501 Bu--F Et 4-i-Pr I 7502 Bu--F Et 2-Br, 4- H CF.sub.3 7503 Bu--F Et 2-Br, 4- SnMe.sub.3 CF.sub.3 7504 Bu--F Et 2-Br, 4- Br CF.sub.3 7505 Bu--F Et 2-Br, 4- I CF.sub.3 7506 Bu--F Et 2-CF.sub.3, 4- H Br 7507 Bu--F Et 2-CF.sub.3, 4- SnMe.sub.3 Br 7508 Bu--F Et 2-CF.sub.3, 4- Br Br 7509 Bu--F Et 2-CF.sub.3, 4- I Br 7510 Bu--F Et 2-Br, 4-Br H 7511 Bu--F Et 2-Br, 4-Br SnMe.sub.3 7512 Bu--F Et 2-Br, 4-Br Br 7513 Bu--F Et 2-Br, 4-Br I 7514 Bu--F Et 2-Br, 4- H Me 7515 Bu--F Et 2-Br, 4- SnMe.sub.3 Me 7516 Bu--F Et 2-Br, 4- Br Me 7517 Bu--F Et 2-Br, 4- I Me 7518 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H H 7519 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H SnMe.sub.3 7520 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H Br 7521 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H I 7522 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F H 7523 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F SnMe.sub.3 7524 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-F Br 7525 FCH.sub.2--CH--CH--CH.sub.2 Me 4-F I 7526 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F H 7527 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F SnMe.sub.3 7528 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F Br 7529 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 5-F I 7530 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl H 7531 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl SnMe.sub.3 7532 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl Br 7533 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Cl I 7534 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br H 7535 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br SnMe.sub.3 7536 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br Br 7537 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br I 7538 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me H 7539 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me SnMe.sub.3 7540 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me Br 7541 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me I 7542 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 H 7543 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 SnMe.sub.3 7544 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 Br 7545 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-CF.sub.3 I 7546 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH H 7547 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH SnMe.sub.3 7548 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH Br 7549 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH I 7550 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe H 7551 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe SnMe.sub.3 7552 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe Br 7553 FCH.sub.2--CH--CH--CH.sub.2 Me 4-OMe I 7554 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF H 7555 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF SnMe.sub.3 7556 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF Br 7557 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF I 7558 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 H 7559 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 SnMe.sub.3 7560 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 Br 7561 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 I 7562 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF H 7563 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF SnMe.sub.3 7564 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF Br 7565 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF I 7566 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF H 7567 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF SnMe.sub.3 7568 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF Br 7569 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF I 7570 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr H 7571 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr SnMe.sub.3 7572 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr Br 7573 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-i-Pr I 7574 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- H CF.sub.3 7575 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- SnMe.sub.3 CF.sub.3 7576 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- Br CF.sub.3 7577 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- I CF.sub.3 7578 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4- H Br 7579 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4- SnMe.sub.3 Br 7580 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4- Br Br 7581 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3, 4- I Br 7582 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br H 7583 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br SnMe.sub.3 7584 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br Br 7585 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4-Br I 7586 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- H Me 7587 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- SnMe.sub.3 Me 7588 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- BI- Me 7589 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 4- I Me 7590 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H PI 7591 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H SnMe.sub.3 7592 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H Br 7593 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H I 7594 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F H 7595 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F SnMe.sub.3 7596 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F Br 7597 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-F I 7598 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F H 7599 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F SnMe.sub.3 7600 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F Br 7601 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 5-F I 7602 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl H 7603 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl SnMe.sub.3 7604 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl Br 7605 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Cl I 7606 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br H 7607 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br SnMe.sub.3 7608 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br Br 7609 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br I 7610 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me H 7611 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me SnMe.sub.3 7612 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me Br 7613 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me I 7614 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 H 7615 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 SnMe.sub.3 7616 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 Br 7617 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-CF.sub.3 I 7618 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH H 7619 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH SnMe.sub.3 7620 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH Br 7621 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH I 7622 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe H 7623 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe SnMe.sub.3 7624 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe Br 7625 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe I 7626 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF H 7627 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF SnMe.sub.3 7628 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF Br 7629 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF I 7630 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 H 7631 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 SnMe.sub.3 7632 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 Br 7633 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 I 7634 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF H 7635 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF SnMe.sub.3 7636 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF Br 7637 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF I 7638 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF H 7639 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF SnMe.sub.3 7640 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF Br 7641 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF I 7642 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr H 7643 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr SnMe.sub.3 7644 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr Br 7645 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-i-Pr I 7646 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- H CF.sub.3 7647 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- SnMe.sub.3 CF.sub.3 7648 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- Br CF.sub.3 7649 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- I CF.sub.3 7650 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CFI, 4- H Br 7651 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4- SnMe.sub.3 Br 7652 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4- Br Br 7653 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3, 4- I

Br 7654 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br H 7655 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br SnMe.sub.3 7656 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br Br 7657 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4-Br I 7658 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- H Me 7659 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- SnMe.sub.3 Me 7660 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- Br Me 7661 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 4- I Me 7662 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H H 7663 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H SnMe.sub.3 7664 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H Br 7665 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H I 7666 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-F H 7667 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-F SnMe.sub.3 7668 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-F Br 7669 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-F I 7670 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 5-F H 7671 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 5-F SnMe.sub.3 7672 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 5-F Br 7673 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 5-F I 7674 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Cl H 7675 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Cl SnMe.sub.3 7676 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Cl Br 7677 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Cl I 7678 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br H 7679 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br SnMe.sub.3 7680 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br Br 7681 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br I 7682 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me H 7683 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me SnMe.sub.3 7684 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me Br 7685 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me I 7686 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-CF.sub.3 H 7687 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-CF.sub.3 SnMe.sub.3 7688 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-CF.sub.3 Br 7689 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-CF.sub.3 I 7690 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH H 7691 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH SnMe.sub.3 7692 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH Br 7693 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH I 7694 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe H 7695 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe SnMe.sub.3 7696 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe Br 7697 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe I 7698 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF H 7699 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-UMel, SnMe.sub.3 7700 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF Br 7701 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF I 7702 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 H 7703 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 SnMe.sub.3 7704 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 Br 7705 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 I 7706 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF H 7707 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF SnMe.sub.3 7708 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF Br 7709 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF I 7710 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF H 7711 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF SnMe.sub.3 7712 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF Br 7713 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF I 7714 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-i-Pr H 7715 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-i-Pr SnMe.sub.3 7716 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-i-Pr Br 7717 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-i-Pr I 7718 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- H CF.sub.3 7719 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- SnMe.sub.3 CF.sub.3 7720 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- Br CF.sub.3 7721 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- I CF.sub.3 7722 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4- H Br 7723 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4- SnMe.sub.3 Br 7724 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4- Br Br 7725 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3, 4- I Br 7726 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br H 7727 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br SnMe.sub.3 7728 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br Br 7729 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4-Br I 7730 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- H Me 7731 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- SnMe.sub.3 Me 7732 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- Br Me 7733 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 4- I Me

TABLE-US-00022 TABLE 7 Substituent list for compounds of general structure XII. XII ##STR00094## Compound # R.sup.1 -- R.sup.2 = R.sup.5 = X.sup.2 = 7734 Bu Et H H 7735 Bu Et H SnMe.sub.3 7736 Bu Et H Br 7737 Bu Et H I 7738 Bu Et 2-F H 7739 Bu Et 2-F SnMe.sub.3 7740 Bu Et 2-F Br 7741 Bu Et 2-F I 7742 Bu Et 2-Cl H 7743 Bu Et 2-Cl SnMe.sub.3 7744 Bu Et 2-Cl Br 7745 Bu Et 2-Cl I 7746 Bu Et 2-Br H 7747 Bu Et 2-Br SnMe.sub.3 7748 Bu Et 2-Br Br 7749 Bu Et 2-Br I 7750 Bu Et 2-Me H 7751 Bu Et 2-Me SnMe.sub.3 7752 Bu Et 2-Me Br 7753 Bu Et 2-Me I 7754 Bu Et 2-Et H 7755 Bu Et 2-Et SnMe.sub.3 7756 Bu Et 2-Et Br 7757 Bu Et 2-Et I 7758 Bu Et 2-Me, H 6-Me 7759 Bu Et 2-Me, SnMe.sub.3 6-Me 7760 Bu Et 2-Me, Br 6-Me 7761 Bu Et 2-Me, I 6-Me 7762 Bu Et 2-OH H 7763 Bu Et 2-OH SnMe.sub.3 7764 Bu Et 2-OH Br 7765 Bu Et 2-OH I 7766 Bu Et 2-OMe H 7767 Bu Et 2-OMe SnMe.sub.3 7768 Bu Et 2-OMe Br 7769 Bu Et 2-OMe I 7770 Bu Et 2- H OMeF 7771 Bu Et 2- SnMe.sub.3 OMeF 7772 Bu Et 2- Br OMeF 7773 Bu Et 2- I OMeF 7774 Bu Et 2-OCF.sub.3 H 7775 Bu Et 2-OCF.sub.3 SnMe.sub.3 7776 Bu Et 2-OCF.sub.3 Br 7777 Bu Et 2-OCF.sub.3 I 7778 Bu Et 2-OEtF H 7779 Bu Et 2-OEtF SnMe.sub.3 7780 Bu Et 2-OEtF Br 7781 Bu Et 2-OEtF I 7782 Bu Et 2-OPrF H 7783 Bu Et 2-OPrF SnMe.sub.3 7784 Bu Et 2-OPrF Br 7785 Bu Et 2-OPrF I 7786 Bu Et 2-CF.sub.3 H 7787 Bu Et 2-CF.sub.3 SnMe.sub.3 7788 Bu Et 2-CF.sub.3 Br 7789 Bu Et 2-CF.sub.3 I 7790 Bu Et 2-Br, 6- H CF.sub.3 7791 Bu Et 2-Br, 6- SnMe.sub.3 CF.sub.3 7792 Bu Et 2-Br, 6- Br CF.sub.3 7793 Bu Et 2-Br, 6- I CF.sub.3 7794 Bu Et 2-Br, 6- H Br 7795 Bu Et 2-Br, 6- SnMe.sub.3 Br 7796 Bu Et 2-Br, 6- Br Br 7797 Bu Et 2-Br, 6- I Br 7798 Pr Pr H H 7799 Pr Pr H SnMe.sub.3 7800 Pr Pr H Br 7801 Pr Pr H I 7802 Pr Pr 2-F H 7803 Pr Pr 2-F SnMe.sub.3 7804 Pr Pr 2-F Br 7805 Pr Pr 2-F I 7806 Pr Pr 2-Cl H 7807 Pr Pr 2-Cl SnMe.sub.3 7808 Pr Pr 2-Cl Br 7809 Pr Pr 2-Cl I 7810 Pr Pr 2-Br H 7811 Pr Pr 2-Br SnMe.sub.3 7812 Pr Pr 2-Br Br 7813 Pr Pr 2-Br I 7814 Pr Pr 2-Me H 7815 Pr Pr 2-Me SnMe.sub.3 7816 Pr Pr 2-Me Br 7817 Pr Pr 2-Me I 7818 Pr Pr 2-Et H 7819 Pr Pr 2-Et SnMe.sub.3 7820 Pr Pr 2-Et Br 7821 Pr Pr 2-Et I 7822 Pr Pr 2-Me, H 6-Me 7823 Pr Pr 2-Me, SnMe.sub.3 6-Me 7824 Pr Pr 2-Me, Br 6-Me 7825 Pr Pr 2-Me, I 6-Me 7826 Pr Pr 2-OH H 7827 Pr Pr 2-OH SnMe.sub.3 7828 Pr Pr 2-OH Br 7829 Pr Pr 2-OH I 7830 Pr Pr 2-OMe H 7831 Pr Pr 2-OMe SnMe.sub.3 7832 Pr Pr 2-OMe Br 7833 Pr Pr 2-OMe I 7834 Pr Pr 2- H OMeF 7835 Pr Pr 2- SnMe.sub.3 OMeF 7836 Pr Pr 2- Br OMeF 7837 Pr Pr 2- I OMeF 7838 Pr Pr 2-OCF.sub.3 H 7839 Pr Pr 2-OCF.sub.3 SnMe.sub.3 7840 Pr Pr 2-OCF.sub.3 Br 7841 Pr Pr 2-OCF.sub.3 I 7842 Pr Pr 2-OEtF H 7843 Pr Pr 2-OEtF SnMe.sub.3 7844 Pr Pr 2-OEtF Br 7845 Pr Pr 2-OEtF I 7846 Pr Pr 2-OPrF H 7847 Pr Pr 2-OPrF SnMe.sub.3 7848 Pr Pr 2-OPrF Br 7849 Pr Pr 2-OPrF I 7850 Pr Pr 2-CF.sub.3 H 7851 Pr Pr 2-CF.sub.3 SnMe.sub.3 7852 Pr Pr 2-CF.sub.3 Br 7853 Pr Pr 2-CF.sub.3 I 7854 Pr Pr 2-Br, 6- H CF.sub.3 7855 Pr Pr 2-Br, 6- SnMe.sub.3 CF.sub.3 7856 Pr Pr 2-Br, 6- Br CF.sub.3 7857 Pr Pr 2-Br, 6- I CF.sub.3 7858 Pr Pr 2-Br, 6- H Br 7859 Pr Pr 2-Br, 6- SnMe.sub.3 Br 7860 Pr Pr 2-Br, 6- Br Br 7861 Pr Pr 2-Br, 6- I Br 7862 Pr Pr--F H H 7863 Pr Pr--F H SnMe.sub.3 7864 Pr Pr--F H Br 7865 Pr Pr--F H I 7866 Pr Pr--F 2-F H 7867 Pr Pr--F 2-F SnMe.sub.3 7868 Pr Pr--F 2-F Br 7869 Pr Pr--F 2-F I 7870 Pr Pr--F 2-Cl H 7871 Pr Pr--F 2-Cl SnMe.sub.3 7872 Pr Pr--F 2-Cl Br 7873 Pr Pr--F 2-Cl I 7874 Pr Pr--F 2-Br H 7875 Pr Pr--F 2-Br SnMe.sub.3 7876 Pr Pr--F 2-Br Br 7877 Pr Pr--F 2-Br I 7878 Pr Pr--F 2-Me H 7879 Pr Pr--F 2-Me SnMe.sub.3 7880 Pr Pr--F 2-Me Br 7881 Pr Pr--F 2-Me I 7882 Pr Pr--F 2-Et H 7883 Pr Pr--F 2-Et SnMe.sub.3 7884 Pr Pr--F 2-Et Br 7885 Pr Pr--F 2-Et I 7886 Pr Pr--F 2-Me, H 6-Me 7887 Pr Pr--F 2-Me, SnMe.sub.3 6-Me 7888 Pr Pr--F 2-Me, Br 6-Me 7889 Pr Pr--F 2-Me, I 6-Me 7890 Pr Pr--F 2-OH H 7891 Pr Pr--F 2-OH SnMe.sub.3 7892 Pr Pr--F 2-OH Br 7893 Pr Pr--F 2-OH I 7894 Pr Pr--F 2-OMe H 7895 Pr Pr--F 2-OMe SnMe.sub.3 7896 Pr Pr--F 2-OMe Br 7897 Pr Pr--F 2-OMe I 7898 Pr Pr--F 2- H OMeF 7899 Pr Pr--F 2- SnMe.sub.3 OMeF 7900 Pr Pr--F 2- Br OMeF 7901 Pr Pr--F 2- I OMeF 7902 Pr Pr--F 2-OCF.sub.3 H 7903 Pr Pr--F 2-OCF.sub.3 SnMe.sub.3 7904 Pr Pr--F 2-OCF.sub.3 Br 7905 Pr Pr--F 2-OCF.sub.3 I 7906 Pr Pr--F 2-OEtF H 7907 Pr Pr--F 2-OEtF SnMe.sub.3 7908 Pr Pr--F 2-OEtF Br 7909 Pr Pr--F 2-OEtF I 7910 Pr Pr--F 2-OPrF H 7911 Pr Pr--F 2-OPrF SnMe.sub.3 7912 Pr Pr--F 2-OPrF Br 7913 Pr Pr--F 2-OPrF I 7914 Pr Pr--F 2-CF.sub.3 H 7915 Pr Pr--F 2-CF.sub.3 SnMe.sub.3 7916 Pr Pr--F 2-CF.sub.3 Br 7917 Pr Pr--F 2-CF.sub.3 I 7918 Pr Pr--F 2-Br, 6- H CF.sub.3 7919 Pr Pr--F 2-Br, 6- SnMe.sub.3 CF.sub.3 7920 Pr Pr--F 2-Br, 6- Br CF.sub.3 7921 Pr Pr--F 2-Br, 6- I CF.sub.3 7922 Pr Pr--F 2-Br, 6- H Br 7923 Pr Pr--F 2-Br, 6- SnMe.sub.3 Br 7924 Pr Pr--F 2-Br, 6- Br Br 7925 Pr Pr--F 2-Br, 6- I Br 7926 Pr Et--F H H 7927 Pr Et--F H SnMe.sub.3

7928 Pr Et--F H Br 7929 Pr Et--F H I 7930 Pr Et--F 2-F H 7931 Pr Et--F 2-F SnMe.sub.3 7932 Pr Et--F 2-F Br 7933 Pr Et--F 2-F I 7934 Pr Et--F 2-Cl H 7935 Pr Et--F 2-Cl SnMe.sub.3 7936 Pr Et--F 2-Cl Br 7937 Pr Et--F 2-Cl I 7938 Pr Et--F 2-Br H 7939 Pr Et--F 2-Br SnMe.sub.3 7940 Pr Et--F 2-Br Br 7941 Pr Et--F 2-Br I 7942 Pr Et--F 2-Me H 7943 Pr Et--F 2-Me SnMe.sub.3 7944 Pr Et--F 2-Me Br 7945 Pr Et--F 2-Me I 7946 Pr Et--F 2-Et H 7947 Pr Et--F 2-Et SnMe.sub.3 7948 Pr Et--F 2-Et Br 7949 Pr Et--F 2-Et I 7950 Pr Et--F 2-Me, H 6-Me 7951 Pr Et--F 2-Me, SnMe.sub.3 6-Me 7952 Pr Et--F 2-Me, Br 6-Me 7953 Pr Et--F 2-Me, I 6-Me 7954 Pr Et--F 2-OH H 7955 Pr Et--F 2-OH SnMe.sub.3 7956 Pr Et--F 2-OH Br 7957 Pr Et--F 2-OH I 7958 Pr Et--F 2-OMe H 7959 Pr Et--F 2-OMe SnMe.sub.3 7960 Pr Et--F 2-OMe Br 7961 Pr Et--F 2-OMe I 7962 Pr Et--F 2- H OMeF 7963 Pr Et--F 2- SnMe.sub.3 OMeF 7964 Pr Et--F 2- Br OMeF 7965 Pr Et--F 2- I OMeF 7966 Pr Et--F 2-OCF.sub.3 H 7967 Pr Et--F 2-OCF.sub.3 SnMe.sub.3 7968 Pr Et--F 2-OCF.sub.3 Br 7969 Pr Et--F 2-OCF.sub.3 I 7970 Pr Et--F 2-OEtF H 7971 Pr Et--F 2-OEtF SnMe.sub.3 7972 Pr Et--F 2-OEtF Br 7973 Pr Et--F 2-OEtF I 7974 Pr Et--F 2-OPrF H 7975 Pr Et--F 2-OPrF SnMe.sub.3 7976 Pr Et--F 2-OPrF Br 7977 Pr Et--F 2-OPrF I 7978 Pr Et--F 2-CF.sub.3 H 7979 Pr Et--F 2-CF.sub.3 SnMe.sub.3 7980 Pr Et--F 2-CF.sub.3 Br 7981 Pr Et--F 2-CF.sub.3 I 7982 Pr Et--F 2-Br, 6- H CF.sub.3 7983 Pr Et--F 2-Br, 6- SnMe.sub.3 CF.sub.3 7984 Pr Et--F 2-Br, 6- Br CF.sub.3 7985 Pr Et--F 2-Br, 6- I CF.sub.3 7986 Pr Et--F 2-Br, 6- H Br 7987 Pr Et--F 2-Br, 6- SnMe.sub.3 Br 7988 Pr Et--F 2-Br, 6- Br Br 7989 Pr Et--F 2-Br, 6- I Br 7990 Pr--F Et H H 7991 Pr--F Et H SnMe.sub.3 7992 Pr--F Et H Br 7993 Pr--F Et H I 7994 Pr--F Et 2-F H 7995 Pr--F Et 2-F SnMe.sub.3 7996 Pr--F Et 2-F Br 7997 Pr--F Et 2-F I 7998 Pr--F Et 2-Cl H 7999 Pr--F Et 2-Cl SnMe.sub.3 8000 Pr--F Et 2-Cl Br 8001 Pr--F Et 2-Cl I 8002 Pr--F Et 2-Br H 8003 Pr--F Et 2-Br SnMe.sub.3 8004 Pr--F Et 2-Br Br 8005 Pr--F Et 2-Br I 8006 Pr--F Et 2-Me H 8007 Pr--F Et 2-Me SnMe.sub.3 8008 Pr--F Et 2-Me Br 8009 Pr--F Et 2-Me I 8010 Pr--F Et 2-Et H 8011 Pr--F Et 2-Et SnMe.sub.3 8012 Pr--F Et 2-Et Br 8013 Pr--F Et 2-Et I 8014 Pr--F Et 2-Me, H 6-Me 8015 Pr--F Et 2-Me, SnMe.sub.3 6-Me 8016 Pr--F Et 2-Me, Br 6-Me 8017 Pr--F Et 2-Me, I 6-Me 8018 Pr--F Et 2-OH H 8019 Pr--F Et 2-OH SnMe.sub.3 8020 Pr--F Et 2-OH Br 8021 Pr--F Et 2-OH I 8022 Pr--F Et 2-OMe H 8023 Pr--F Et 2-OMe SnMe.sub.3 8024 Pr--F Et 2-OMe Br 8025 Pr--F Et 2-OMe I 8026 Pr--F Et 2- H OMeF 8027 Pr--F Et 2- SnMe.sub.3 OMeF 8028 Pr--F Et 2- Br OMeF 8029 Pr--F Et 2- I OMeF 8030 Pr--F Et 2-OCF.sub.3 H 8031 Pr--F Et 2-OCF.sub.3 SnMe.sub.3 8032 Pr--F Et 2-OCF.sub.3 Br 8033 Pr--F Et 2-OCF.sub.3 I 8034 Pr--F Et 2-OEtF H 8035 Pr--F Et 2-OEtF SnMe.sub.3 8036 Pr--F Et 2-OEtF Br 8037 Pr--F Et 2-OEtF I 8038 Pr--F Et 2-OPrF H 8039 Pr--F Et 2-OPrF SnMe.sub.3 8040 Pr--F Et 2-OPrF Br 8041 Pr--F Et 2-OPrF I 8042 Pr--F Et 2-CF.sub.3 H 8043 Pr--F Et 2-CF.sub.3 SnMe.sub.3 8044 Pr--F Et 2-CF.sub.3 Br 8045 Pr--F Et 2-CF.sub.3 I 8046 Pr--F Et 2-Br, 6- H CF.sub.3 8047 Pr--F Et 2-Br, 6- SnMe.sub.3 CF.sub.3 8048 Pr--F Et 2-Br, 6- Br CF.sub.3 8049 Pr--F Et 2-Br, 6- I CF.sub.3 8050 Pr--F Et 2-Br, 6- H Br 8051 Pr--F Et 2-Br, 6- SnMe.sub.3 Br 8052 Pr--F Et 2-Br, 6- Br Br 8053 Pr--F Et 2-Br, 6- I Br 8054 Bu Et--F H H 8055 Bu Et--F H SnMe.sub.3 8056 Bu Et--F H Br 8057 Bu Et--F H I 8058 Bu Et--F 2-F H 8059 Bu Et--F 2-F SnMe.sub.3 8060 Bu Et--F 2-F Br 8061 Bu Et--F 2-F I 8062 Bu Et--F 2-Cl H 8063 Bu Et--F 2-Cl SnMe.sub.3 8064 Bu Et--F 2-Cl Br 8065 Bu Et--F 2-Cl I 8066 Bu Et--F 2-Br H 8067 Bu Et--F 2-Br SnMe.sub.3 8068 Bu Et--F 2-Br Br 8069 Bu Et--F 2-Br I 8070 Bu Et--F 2-Me H 8071 Bu Et--F 2-Me SnMe.sub.3 8072 Bu Et--F 2-Me Br 8073 Bu Et--F 2-Me I 8074 Bu Et--F 2-Et H 8075 Bu Et--F 2-Et SnMe.sub.3 8076 Bu Et--F 2-Et Br 8077 Bu Et--F 2-Et I 8078 Bu Et--F 2-Me, H 6-Me 8079 Bu Et--F 2-Me, SnMe.sub.3 6-Me 8080 Bu Et--F 2-Me, Br 6-Me 8081 Bu Et--F 2-Me, I 6-Me 8082 Bu Et--F 2-OH H 8083 Bu Et--F 2-OH SnMe.sub.3 8084 Bu Et--F 2-OH Br 8085 Bu Et--F 2-OH I 8086 Bu Et--F 2-OMe H 8087 Bu Et--F 2-OMe SnMe.sub.3 8088 Bu Et--F 2-OMe Br 8089 Bu Et--F 2-OMe I 8090 Bu Et--F 2- H OMeF 8091 Bu Et--F 2- SnMe.sub.3 OMeF 8092 Bu Et--F 2- Br OMeF 8093 Bu Et--F 2- I OMeF 8094 Bu Et--F 2-OCF.sub.3 H 8095 Bu Et--F 2-OCF.sub.3 SnMe.sub.3 8096 Bu Et--F 2-OCF.sub.3 Br 8097 Bu Et--F 2-OCF.sub.3 I 8098 Bu Et--F 2-OEtF H 8099 Bu Et--F 2-OEtF SnMe.sub.3 8100 Bu Et--F 2-OEtF Br 8101 Bu Et--F 2-OEtF I 8102 Bu Et--F 2-OPrF H 8103 Bu Et--F 2-OPrF SnMe.sub.3 8104 Bu Et--F 2-OPrF Br 8105 Bu Et--F 2-OPrF I 8106 Bu Et--F 2-CF.sub.3 H 8107 Bu Et--F 2-CF.sub.3 SnMe.sub.3 8108 Bu Et--F 2-CF.sub.3 Br 8109 Bu Et--F 2-CF.sub.3 I 8110 Bu Et--F 2-Br, 6- H CF.sub.3 8111 Bu Et--F 2-Br, 6- SnMe.sub.3 CF.sub.3 8112 Bu Et--F 2-Br, 6- Br CF.sub.3 8113 Bu Et--F 2-Br, 6- I CF.sub.3 8114 Bu Et--F 2-Br, 6- H Br 8115 Bu Et--F 2-Br, 6- SnMe.sub.3 Br 8116 Bu Et--F 2-Br, 6- Br Br 8117 Bu Et--F 2-Br, 6- I Br 8118 Bu--F Et H H 8119 Bu--F Et H SnMe.sub.3 8120 Bu--F Et H Br 8121 Bu--F Et H I 8122 Bu--F Et 2-F H 8123 Bu--F Et 2-F SnMe.sub.3 8124 Bu--F Et 2-F Br 8125 Bu--F Et 2-F I 8126 Bu--F Et 2-Cl H 8127 Bu--F Et 2-Cl SnMe.sub.3 8128 Bu--F Et 2-Cl Br 8129 Bu--F Et 2-Cl I 8130 Bu--F Et 2-Br H

8131 Bu--F Et 2-Br SnMe.sub.3 8132 Bu--F Et 2-Br Br 8133 Bu--F Et 2-Br I 8134 Bu--F Et 2-Me H 8135 Bu--F Et 2-Me SnMe.sub.3 8136 Bu--F Et 2-Me Br 8137 Bu--F Et 2-Me I 8138 Bu--F Et 2-Et H 8139 Bu--F Et 2-Et SnMe.sub.3 8140 Bu--F Et 2-Et Br 8141 Bu--F Et 2-Et I 8142 Bu--F Et 2-Me, H 6-Me 8143 Bu--F Et 2-Me, SnMe.sub.3 6-Me 8144 Bu--F Et 2-Me, Br 6-Me 8145 Bu--F Et 2-Me, I 6-Me 8146 Bu--F Et 2-OH H 8147 Bu--F Et 2-OH SnMe.sub.3 8148 Bu--F Et 2-OH Br 8149 Bu--F Et 2-OH I 8150 Bu--F Et 2-OMe H 8151 Bu--F Et 2-OMe SnMe.sub.3 8152 Bu--F Et 2-OMe Br 8153 Bu--F Et 2-OMe I 8154 Bu--F Et 2- H OMeF 8155 Bu--F Et 2- SnMe.sub.3 OMeF 8156 Bu--F Et 2- Br OMeF 8157 Bu--F Et 2- I OMeF 8158 Bu--F Et 2-OCF.sub.3 H 8159 Bu--F Et 2-OCF.sub.3 SnMe.sub.3 8160 Bu--F Et 2-OCF.sub.3 Br 8161 Bu--F Et 2-OCF.sub.3 I 8162 Bu--F Et 2-OEtF H 8163 Bu--F Et 2-OEtF SnMe.sub.3 8164 Bu--F Et 2-OEtF Br 8165 Bu--F Et 2-OEtF I 8166 Bu--F Et 2-OPrF H 8167 Bu--F Et 2-OPrF SnMe.sub.3 8168 Bu--F Et 2-OPrF Br 8169 Bu--F Et 2-OPrF I 8170 Bu--F Et 2-CF.sub.3 H 8171 Bu--F Et 2-CF.sub.3 SnMe.sub.3 8172 Bu--F Et 2-CF.sub.3 Br 8173 Bu--F Et 2-CF.sub.3 I 8174 Bu--F Et 2-Br, 6- H CF.sub.3 8175 Bu--F Et 2-Br, 6- SnMe.sub.3 CF.sub.3 8176 Bu--F Et 2-Br, 6- Br CF.sub.3 8177 Bu--F Et 2-Br, 6- I CF.sub.3 8178 Bu--F Et 2-Br, 6- H Br 8179 Bu--F Et 2-Br, 6- SnMe.sub.3 Br 8180 Bu--F Et 2-Br, 6- Br Br 8181 Bu--F Et 2-Br, 6- I Br 8182 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H H 8183 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H SnMe.sub.3 8184 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H Br 8185 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H I 8186 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F H 8187 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F SnMe.sub.3 8188 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F Br 8189 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-F I 8190 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl H 8191 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl SnMe.sub.3 8192 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl Br 8193 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl I 8194 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br H 8195 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br SnMe.sub.3 8196 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br Br 8197 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br I 8198 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me H 8199 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me SnMe.sub.3 8200 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me Br 8201 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me I 8202 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et H 8203 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et SnMe.sub.3 8204 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et Br 8205 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Et I 8206 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, H 6-Me 8207 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, SnMe.sub.3 6-Me 8208 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, Br 6-Me 8209 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me, I 6-Me 8210 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH H 8211 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH SnMe.sub.3 8212 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH Br 8213 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH I 8214 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe H 8215 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe SnMe.sub.3 8216 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe Br 8217 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe I 8218 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2- H OMeF 8219 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2- SnMe.sub.3 OMeF 8220 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2- Br OMeF 8221 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2- I OMeF 8222 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 H 8223 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 SnMe.sub.3 8224 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 Br 8225 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 I 8226 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF H 8227 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF SnMe.sub.3 8228 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF Br 8229 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF I 8230 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF H 8231 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF SnMe.sub.3 8232 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF Br 8233 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF I 8234 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 H 8235 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 SnMe.sub.3 8236 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 Br 8237 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-CF.sub.3 I 8238 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- H CF.sub.3 8239 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- SnMe.sub.3 CF.sub.3 8240 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- Br CF.sub.3 8241 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- I CF.sub.3 8242 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- H Br 8243 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- SnMe.sub.3 Br 8244 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- Br Br 8245 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Br, 6- I Br 8246 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H H 8247 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H SnMe.sub.3 8248 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H Br 8249 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H I 8250 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F H 8251 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F SnMe.sub.3 8252 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F Br 8253 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-F I 8254 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl H 8255 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl SnMe.sub.3 8256 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl Br 8257 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl I 8258 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br H 8259 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br SnMe.sub.3 8260 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br Br 8261 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br I 8262 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me H 8263 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me SnMe.sub.3 8264 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me Br 8265 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me I 8266 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et H 8267 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et SnMe.sub.3 8268 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et Br 8269 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Et I 8270 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, H 6-Me 8271 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, SnMe.sub.3 6-Me 8272 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, Br 6-Me 8273 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me, I 6-Me 8274 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH H 8275 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH SnMe.sub.3 8276 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH Br 8277 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH I 8278 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe H 8279 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe SnMe.sub.3 8280 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe Br 8281 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe I 8282 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2- H OMeF 8283 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2- SnMe.sub.3 OMeF 8284 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2- Br OMeF 8285 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2- I OMeF 8286 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 H 8287 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 SnMe.sub.3 8288 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 Br 8289 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 I 8290 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF H 8291 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF SnMe.sub.3 8292 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF Br 8293 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF I 8294 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF H 8295 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF SnMe.sub.3 8296 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF Br 8297 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF I 8298 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 H 8299 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 SnMe.sub.3 8300 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 Br 8301 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-CF.sub.3 I 8302 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- H CF.sub.3 8303 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- SnMe.sub.3 CF.sub.3 8304 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- Br CF.sub.3 8305 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- I CF.sub.3 8306 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- H Br 8307 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- SnMe.sub.3 Br 8308 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- Br Br 8309 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br, 6- I Br 8310 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H H 8311 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H SnMe.sub.3 8312 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H Br 8313 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H I 8314 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F H 8315 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F SnMe.sub.3 8316 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F Br 8317 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-F I 8318 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl H 8319 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl SnMe.sub.3 8320 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl Br 8321 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl I 8322 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br H 8323 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br SnMe.sub.3 8324 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br Br 8325 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br I 8326 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me H 8327 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me SnMe.sub.3 8328 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me Br 8329 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me I 8330 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et H 8331 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et SnMe.sub.3 8332 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et Br 8333 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Et I

8334 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, H 6-Me 8335 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, SnMe.sub.3 6-Me 8336 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, Br 6-Me 8337 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me, I 6-Me 8338 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH H 8339 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH SnMe.sub.3 8340 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH Br 8341 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH I 8342 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe H 8343 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe SnMe.sub.3 8344 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe Br 8345 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe I 8346 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2- H OMeF 8347 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2- SnMe.sub.3 OMeF 8348 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2- Br OMeF 8349 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2- I OMeF 8350 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 H 8351 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 SnMe.sub.3 8352 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 Br 8353 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 I 8354 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF H 8355 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF SnMe.sub.3 8356 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF Br 8357 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF I 8358 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF H 8359 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF SnMe.sub.3 8360 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF Br 8361 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF I 8362 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3 H 8363 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3 SnMe.sub.3 8364 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3 Br 8365 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-CF.sub.3 I 8366 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- H CF.sub.3 8367 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- SnMe.sub.3 CF.sub.3 8368 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- Br CF.sub.3 8369 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- I CF.sub.3 8370 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- H Br 8371 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- SnMe.sub.3 Br 8372 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- Br Br 8373 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br, 6- I Br

TABLE-US-00023 TABLE 8 Substituent list for compounds of general structure XIII. XIII ##STR00095## Com- pound # R.sup.1 = R.sup.2 = R.sup.6 = R.sup.7 = 8374 Bu Et H H 8375 Bu Et 2-Cl, 4-Cl H 8376 Bu Et 2-OMe, H 4-OMe 8377 Bu Et 2-OH H 8378 Bu Et 3-OH H 8379 Bu Et 4-OH H 8380 Bu Et 2-OMe H 8381 Bu Et 3-OMe H 8382 Bu Et 4-OMe H 8383 Bu Et 2-OMeF H 8384 Bu Et 3-OMeF H 8385 Bu Et 4-OMeF H 8386 Bu Et 2-OCF.sub.3 H 8387 Bu Et 3-OCF.sub.3 H 8388 Bu Et 4-OCF.sub.3 H 8389 Bu Et 2-OEtF H 8390 Bu Et 3-OEtF H 8391 Bu Et 4-OEtF H 8392 Bu Et 2-OPrF H 8393 Bu Et 3-OPrF H 8394 Bu Et 4-OPrF H 8395 Bu Et 2-Me H 8396 Bu Et 3-Me H 8397 Bu Et 4-Me H 8398 Bu Et 2-Br H 8399 Bu Et 3-Br H 8400 Bu Et 4-Br H 8401 Bu Et 2-SnMe.sub.3 H 8402 Bu Et 3-SnMe.sub.3 H 8403 Bu Et 4-SnMe.sub.3 H 8404 Bu Et H Me 8405 Bu Et 4-Me Me 8406 Bu Et 4-Br Me 8407 Bu Et 4-SnMe.sub.3 Me 8408 Bu Et 4-OH Me 8409 Bu Et 4-OMe Me 8410 Bu Et 4-OMeF Me 8411 Bu Et 4-OCF.sub.3 Me 8412 Bu Et 4-OEtF Me 8413 Bu Et 4-OPrF Me 8414 Pr Pr H H 8415 Pr Pr 2-Cl, 4-Cl H 8416 Pr Pr 2-OMe, H 4-OMe 8417 Pr Pr 2-OH H 8418 Pr Pr 3-OH H 8419 Pr Pr 4-OH H 8420 Pr Pr 2-OMe H 8421 Pr Pr 3-OMe H 8422 Pr Pr 4-OMe H 8423 Pr Pr 2-OMeF H 8424 Pr Pr 3-OMeF H 8425 Pr Pr 4-OMeF H 8426 Pr Pr 2-OCF.sub.3 H 8427 Pr Pr 3-OCF.sub.3 H 8428 Pr Pr 4-OCF.sub.3 H 8429 Pr Pr 2-OEtF H 8430 Pr Pr 3-OEtF H 8431 Pr Pr 4-OEtF H 8432 Pr Pr 2-OPrF H 8433 Pr Pr 3-OPrF H 8434 Pr Pr 4-OPrF H 8435 Pr Pr 2-Me H 8436 Pr Pr 3-Me H 8437 Pr Pr 4-Me H 8438 Pr Pr 2-Br H 8439 Pr Pr 3-Br H 8440 Pr Pr 4-Br H 8441 Pr Pr 2-SnMe.sub.3 H 8442 Pr Pr 3-SnMe.sub.3 H 8443 Pr Pr 4-SnMe.sub.3 H 8444 Pr Pr H Me 8445 Pr Pr 4-Me Me 8446 Pr Pr 4-Br Me 8447 Pr Pr 4-SnMe.sub.3 Me 8448 Pr Pr 4-OH Me 8449 Pr Pr 4-OMe Me 8450 Pr Pr 4-OMeF Me 8451 Pr Pr 4-OCF.sub.3 Me 8452 Pr Pr 4-OEtF Me 8453 Pr Pr 4-OPrF Me 8454 Pr Pr--F H H 8455 Pr Pr--F 2-Cl, 4-Cl H 8456 Pr Pr--F 2-OMe, H 4-OMe 8457 Pr Pr--F 2-OH H 8458 Pr Pr--F 3-OH H 8459 Pr Pr--F 4-OH H 8460 Pr Pr--F 2-OMe H 8461 Pr Pr--F 3-OMe H 8462 Pr Pr--F 4-OMe H 8463 Pr Pr--F 2-OMeF H 8464 Pr Pr--F 3-OMeF H 8465 Pr Pr--F 4-OMeF H 8466 Pr Pr--F 2-OCF.sub.3 H 8467 Pr Pr--F 3-OCF.sub.3 H 8468 Pr Pr--F 4-OCF.sub.3 H 8469 Pr Pr--F 2-OEtF H 8470 Pr Pr--F 3-OEtF H 8471 Pr Pr--F 4-OEtF H 8472 Pr Pr--F 2-OPrF H 8473 Pr Pr--F 3-OPrF H 8474 Pr Pr--F 4-OPrF H 8475 Pr Pr--F 2-Me H 8476 Pr Pr--F 3-Me H 8477 Pr Pr--F 4-Me H 8478 Pr Pr--F 2-Br H 8479 Pr Pr--F 3-Br H 8480 Pr Pr--F 4-Br H 8481 Pr Pr--F 2-SnMe.sub.3 H 8482 Pr Pr--F 3-SnMe.sub.3 H 8483 Pr Pr--F 4-SnMe.sub.3 H 8484 Pr Pr--F H Me 8485 Pr Pr--F 4-Me Me 8486 Pr Pr--F 4-Br Me 8487 Pr Pr--F 4-SnMe.sub.3 Me 8488 Pr Pr--F 4-OH Me 8489 Pr Pr--F 4-OMe Me 8490 Pr Pr--F 4-OMeF Me 8491 Pr Pr--F 4-OCF.sub.3 Me 8492 Pr Pr--F 4-OEtF Me 8493 Pr Pr--F 4-OPrF Me 8494 Pr Et--F H H 8495 Pr Et--F 2-Cl, 4-Cl H 8496 Pr Et--F 2-OMe, H 4-OMe 8497 Pr Et--F 2-OH H 8498 Pr Et--F 3-OH H 8499 Pr Et--F 4-OH H 8500 Pr Et--F 2-OMe H 8501 Pr Et--F 3-OMe H 8502 Pr Et--F 4-OMe H 8503 Pr Et--F 2-OMeF H 8504 Pr Et--F 3-OMeF H 8505 Pr Et--F 4-OMeF H 8506 Pr Et--F 2-OCF.sub.3 H 8507 Pr Et--F 3-OCF.sub.3 H 8508 Pr Et--F 4-OCF.sub.3 H 8509 Pr Et--F 2-OEtF H 8510 Pr Et--F 3-OEtF H 8511 Pr Et--F 4-OEtF H 8512 Pr Et--F 2-OPrF H 8513 Pr Et--F 3-OPrF H 8514 Pr Et--F 4-OPrF H 8515 Pr Et--F 2-Me H 8516 Pr Et--F 3-Me H 8517 Pr Et--F 4-Me H 8518 Pr Et--F 2-Br H 8519 Pr Et--F 3-Br H 8520 Pr Et--F 4-Br H 8521 Pr Et--F 2-SnMe.sub.3 H 8522 Pr Et--F 3-SnMe.sub.3 H 8523 Pr Et--F 4-SnMe.sub.3 H 8524 Pr Et--F H Me 8525 Pr Et--F 4-Me Me 8526 Pr Et--F 4-Br Me 8527 Pr Et--F 4-SnMe.sub.3 Me 8528 Pr Et--F 4-OH Me 8529 Pr Et--F 4-OMe Me 8530 Pr Et--F 4-OMeF Me 8531 Pr Et--F 4-OCF.sub.3 Me 8532 Pr Et--F 4-OEtF Me 8533 Pr Et--F 4-OPrF Me 8534 Pr--F Et H H 8535 Pr--F Et 2-Cl, 4-Cl H 8536 Pr--F Et 2-OMe, H 4-OMe 8537 Pr--F Et 2-OH H 8538 Pr--F Et 3-OH H 8539 Pr--F Et 4-OH H 8540 Pr--F Et 2-OMe H 8541 Pr--F Et 3-OMe H 8542 Pr--F Et 4-OMe H 8543 Pr--F Et 2-OMeF H 8544 Pr--F Et 3-OMeF H 8545 Pr--F Et 4-OMeF H 8546 Pr--F Et 2-OCF.sub.3 H 8547 Pr--F Et 3-OCF.sub.3 H 8548 Pr--F Et 4-OCF.sub.3 H 8549 Pr--F Et 2-OEtF H 8550 Pr--F Et 3-OEtF H 8551 Pr--F Et 4-OEtF H 8552 Pr--F Et 2-OPrF H 8553 Pr--F Et 3-OPrF H 8554 Pr--F Et 4-OPrF H 8555 Pr--F Et 2-Me H 8556 Pr--F Et 3-Me H 8557 Pr--F Et 4-Me H 8558 Pr--F Et 2-Br H 8559 Pr--F Et 3-Br H 8560 Pr--F Et 4-Br H 8561 Pr--F Et 2-SnMe.sub.3 H 8562 Pr--F Et 3-SnMe.sub.3 H 8563 Pr--F Et 4-SnMe.sub.3 H 8564 Pr--F Et H Me 8565 Pr--F Et 4-Me Me 8566 Pr--F Et 4-Br Me 8567 Pr--F Et 4-SnMe.sub.3 Me 8568 Pr--F Et 4-OH Me 8569 Pr--F Et 4-OMe Me 8570 Pr--F Et 4-OMeF Me 8571 Pr--F Et 4-OCF.sub.3 Me 8572 Pr--F Et 4-OEtF Me 8573 Pr--F Et 4-OPrF Me 8574 Bu Et--F H H 8575 Bu Et--F 2-Cl, 4-Cl H 8576 Bu Et--F 2-OMe, H 4-OMe 8577 Bu Et--F 2-OH H 8578 Bu Et--F 3-OH H 8579 Bu Et--F 4-OH H 8580 Bu Et--F 2-OMe H 8581 Bu Et--F 3-OMe H 8582 Bu Et--F 4-OMe H 8583 Bu Et--F 2-OMeF H 8584 Bu Et--F 3-OMeF H 8585 Bu Et--F 4-OMeF H 8586 Bu Et--F 2-OCF.sub.3 H 8587 Bu Et--F 3-OCF.sub.3 H 8588 Bu Et--F 4-OCF.sub.3 H 8589 Bu Et--F 2-OEtF H 8590 Bu Et--F 3-OEtF H 8591 Bu Et--F 4-OEtF H 8592 Bu Et--F 2-OPrF H 8593 Bu Et--F 3-OPrF H 8594 Bu Et--F 4-OPrF H 8595 Bu Et--F 2-Me H 8596 Bu Et--F 3-Me H 8597 Bu Et--F 4-Me H 8598 Bu Et--F 2-Br H 8599 Bu Et--F 3-Br H 8600 Bu Et--F 4-Br H 8601 Bu Et--F 2-SnMe.sub.3 H 8602 Bu Et--F 3-SnMe.sub.3 H 8603 Bu Et--F 4-SnMe.sub.3 H 8604 Bu Et--F H Me 8605 Bu Et--F 4-Me Me 8606 Bu Et--F 4-Br Me 8607 Bu Et--F 4-SnMe.sub.3 Me 8608 Bu Et--F 4-OH Me

8609 Be Et--F 4-OMe Me 8610 Bu Et--F 4-OMeF Me 8611 Bu Et--F 4-OCF.sub.3 Me 8612 Bu Et--F 4-OEtF Me 8613 Bu Et--F 4-OPrF Me 8614 Bu--F Et H H 8615 Bu--F Et 2-Cl, 4-Cl H 8616 Bu--F Et 2-OMe, H 4-OMe 8617 Bu--F Et 2-OH H 8618 Bu--F Et 3-OH H 8619 Bu--F Et 4-OH H 8620 Bu--F Et 2-OMe H 8621 Bu--F Et 3-OMe H 8622 Bu--F Et 4-OMe H 8623 Bu--F Et 2-OMeF H 8624 Bu--F Et 3-OMeF H 8625 Bu--F Et 4-OMeF H 8626 Bu--F Et 2-OCF.sub.3 H 8627 Bu--F Et 3-OCF.sub.3 H 8628 Bu--F Et 4-OCF.sub.3 H 8629 Bu--F Et 2-OEtF H 8630 Bu--F Et 3-OEtF H 8631 Bu--F Et 4-OEtF H 8632 Bu--F Et 2-OPrF H 8633 Bu--F Et 3-OPrF H 8634 Bu--F Et 4-OPrF H 8635 Bu--F Et 2-Me H 8636 Bu--F Et 3-Me H 8637 Bu--F Et 4-Me H 8638 Bu--F Et 2-Br H 8639 Bu--F Et 3-Br H 8640 Bu--F Et 4-Br H 8641 Bu--F Et 2-SnMe.sub.3 H 8642 Bu--F Et 3-SnMe.sub.3 H 8643 Bu--F Et 4-SnMe.sub.3 H 8644 Bu--F Et H Me 8645 Bu--F Et 4-Me Me 8646 Bu--F Et 4-Br Me 8647 Bu--F Et 4-SnMe.sub.3 Me 8648 Bu--F Et 4-OH Me 8649 Bu--F Et 4-OMe Me 8650 Bu--F Et 4-OMeF Me 8651 Bu--F Et 4-OCF.sub.3 Me 8652 Bu--F Et 4-OEtF Me 8653 Bu--F Et 4-OPrF Me 8654 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H H 8655 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Cl, 4-Cl H 8656 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe, H 4-OMe 8657 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OH H 8658 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OH H 8659 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH H 8660 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMe H 8661 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMe H 8662 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe H 8663 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OMeF H 8664 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OMeF H 8665 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF H 8666 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OCF.sub.3 H 8667 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OCF.sub.3 H 8668 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 H 8669 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OEtF H 8670 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OEtF H 8671 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF H 8672 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-OPrF H 8673 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-OPrF H 8674 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF H 8675 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-Me H 8676 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Me H 8677 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me H 8678 FCH.sub.2--CH--CH--CH.sub.2 Me 2-Br H 8679 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-Br H 8680 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br H 8681 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 2-SnMe.sub.3 H 8682 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 3-SnMe.sub.3 H 8683 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SnMe.sub.3 H 8684 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me H Me 8685 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Me Me 8686 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-Br Me 8687 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-SnMe.sub.3 Me 8688 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OH Me 8689 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMe Me 8690 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OMeF Me 8691 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OCF.sub.3 Me 8692 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OEtF Me 8693 FCH.sub.2--CH.dbd.CH--CH.sub.2 Me 4-OPrF Me 8694 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H H 8695 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Cl, 4-Cl H 8696 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe, H 4-OMe 8697 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OH H 8698 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OH H 8699 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH H 8700 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMe H 8701 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMe H 8702 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe H 8703 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OMeF H 8704 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OMeF H 8705 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF H 8706 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OCF.sub.3 H 8707 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OCF.sub.3 H 8708 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 H 8709 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OEtF H 8710 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OEtF H 8711 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF H 8712 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-OPrF H 8713 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-OPrF H 8714 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF H 8715 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Me H 8716 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Me H 8717 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me H 8718 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-Br H 8719 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-Br H 8720 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br H 8721 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 2-SnMe.sub.3 H 8722 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 3-SnMe.sub.3 H 8723 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SnMe.sub.3 H 8724 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et H Me 8725 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Me Me 8726 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-Br Me 8727 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-SnMe.sub.3 Me 8728 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OH Me 8729 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMe Me 8730 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OMeF Me 8731 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OCF.sub.3 Me 8732 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OEtF Me 8733 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et 4-OPrF Me 8734 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H H 8735 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Cl, 4-Cl H 8736 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe, H 4-OMe 8737 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OH H 8738 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OH H 8739 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH H 8740 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMe H 8741 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OMe H 8742 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe H 8743 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OMeF H 8744 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OMeF H 8745 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF H 8746 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OCF.sub.3 H 8747 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OCF.sub.3 H 8748 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 H 8749 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OEtF H 8750 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OEtF H 8751 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF H 8752 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-OPrF H 8753 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-OPrF H 8754 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF H 8755 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Me H 8756 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-Me H 8757 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me H 8758 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-Br H 8759 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-Br H 8760 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br H 8761 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 2-SnMe.sub.3 H 8762 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 3-SnMe.sub.3 H 8763 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SnMe.sub.3 H 8764 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F H Me 8765 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Me Me 8766 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-Br Me 8767 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-SnMe.sub.3 Me 8768 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OH Me 8769 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMe Me 8770 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OMeF Me 8771 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OCF.sub.3 Me 8772 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OEtF Me 8773 FCH.sub.2--CH.dbd.CH--CH.sub.2 Et--F 4-OPrF Me

TABLE-US-00024 TABLE 9 Substituent list for compounds of general structure XIV. XIV ##STR00096## Com- pound # R.sup.8 = R.sup.3 = n = 8774 Bu H 1 8775 Bu 2-t-Bu 1 8776 Bu 2-Br 1 8777 Bu 3-Br 1 8778 Bu 4-Br 1 8779 Bu 2-I 1 8780 Bu 3-I 1 8781 Bu 4-I 1 8782 Bu 2-SnMe.sub.3 1 8783 Bu 3-SnMe.sub.3 1 8784 Bu 4-SnMe.sub.3 1 8785 Bu 2-Me 1 8786 Bu 3-Me 1 8787 Bu 4-Me 1 8788 Bu 2-OH 1 8789 Bu 3-OH 1 8790 Bu 4-OH 1 8791 Bu 2-OMe 1 8792 Bu 3-OMe 1 8793 Bu 4-OMe 1 8794 Bu 2-OMeF 1 8795 Bu 3-OMeF 1 8796 Bu 4-OMeF 1 8797 Bu 2-OCF.sub.3 1 8798 Bu 3-OCF.sub.3 1 8799 Bu 4-OCF.sub.3 1 8800 Bu 2-OEtF 1 8801 Bu 3-OEtF 1 8802 Bu 4-OEtF 1 8803 Bu 2-OPrF 1 8804 Bu 3-OPrF 1 8805 Bu 4-OPrF 1 8806 Bu 2-SH 1 8807 Bu 3-SH 1 8808 Bu 4-SH 1 8809 Bu 2-SMe 1 8810 Bu 3-SMe 1 8811 Bu 4-SMe 1 8812 Bu 2-SMeF 1 8813 Bu 3-SMeF 1 8814 Bu 4-SMeF 1 8815 Bu 2-SCF.sub.3 1 8816 Bu 3-SCF.sub.3 1 8817 Bu 4-SCF.sub.3 1 8818 Bu 2-SEtF 1 8819 Bu 3-SEtF 1 8820 Bu 4-SEtF 1 8821 Bu 2-SPrF 1 8822 Bu 3-SPrF 1 8823 Bu 4-SPrF 1 8824 Bu 2-OMe, 4-OMe 1 8825 Bu 2-Me, 5-OH 1 8826 Bu 2-Me, 5-OMe 1 8827 Bu 2-Me, 5-OMeF 1 8828 Bu 2-Me, 5-OEtF 1 8829 Bu 2-Me, 5-OPrF 1 8830 Bu 2-Me, 4-OH 1 8831 Bu 2-Me, 4-OMe 1 8832 Bu 2-Me, 4-OMeF 1 8833 Bu 2-Me, 4-OCF.sub.3 1 8834 Bu 2-Me, 4-OEtF 1 8835 Bu 2-Me, 4-OPrF 1 8836 Bu 2-OH, 4-Me 1 8837 Bu 2-OMe, 4-Me 1 8838 Bu 2-OMeF, 4-Me 1 8839 Bu 2-OCF.sub.3, 4-Me 1 8840 Bu 2-OEtF, 4-Me 1 8841 Bu 2-OPrF, 4-Me 1 8842 Bu 2-Cl, 4-OH 1 8843 Bu 2-Cl, 4-OMe 1 8844 Bu 2-Cl, 4-OMeF 1 8845 Bu 2-Cl, 4-OCF.sub.3 1 8846 Bu 2-Cl, 4-OEtF 1 8847 Bu 2-Cl, 4-OPrF 1 8848 Bu 2-F, 4-F 1 8849 Bu 2-Cl, 4-Cl 1 8850 Bu 2-Cl, 4-F 1 8851 Bu 2-Cl, 4-NO.sub.2 1 8852 Bu 2-Cl, 4-NH.sub.2 1 8853 Bu 2-Cl, 4-NHMe 1 8854 Bu 2-Cl, 4-NMe.sub.2 1 8855 Bu 2-Cl, 4-NMe.sub.3OTf 1 8856 Bu 2-Cl, 4-NMe.sub.3I 1 8857 Bu 2-Cl, 5-F 1 8858 Bu 2-Cl, 5-NO.sub.2 1 8859 Bu 2-Cl, 5-NH.sub.2 1 8860 Bu 2-Cl, 5-NHMe 1 8861 Bu 2-Cl, 5-NMe.sub.2 1 8862 Bu 2-Cl, 5-NMe.sub.3OTf 1 8863 Bu 2-Cl, 5-NMe.sub.3I 1 8864 Bu 2-F, 4-Cl 1 8865 Bu 2-NO.sub.2, 4-Cl 1 8866 Bu 2-NH.sub.2, 4-Cl 1 8867 Bu 2-NHMe, 4-Cl 1 8868 Bu 2-NMe.sub.2, 4-Cl 1 8869 Bu 2-NMe.sub.3OTf, 4-Cl 1 8870 Bu 2-NMe.sub.3I, 4-Cl 1 8871 Bu 2-F, 5-Cl 1 8872 Bu 2-NO.sub.2, 5-Cl 1 8873 Bu 2-NH.sub.2, 5-Cl 1 8874 Bu 2-NHMe, 5-Cl 1 8875 Bu 2-NMe.sub.2, 5-Cl 1 8876 Bu 2-NMe.sub.3OTf, 5-Cl 1 8877 Bu 2-NMe.sub.3I, 5-Cl 1 8878 Bu 2-Br, 4-F 1 8879 Bu 2-Br, 4-NO.sub.2 1 8880 Bu 2-Br, 4-NH.sub.2 1 8881 Bu 2-Br, 4-NHMe 1 8882 Bu 2-Br, 4-NMe.sub.2 1 8883 Bu 2-Br, 4-NMe.sub.3OTf 1 8884 Bu 2-Br, 4-NMe.sub.3I 1 8885 Bu 2-Br, 5-F 1 8886 Bu 2-Br, 5-NO.sub.2 1 8887 Bu 2-Br, 5-NH.sub.2 1 8888 Bu 2-Br, 5-NHMe 1 8889 Bu 2-Br, 5-NMe.sub.2 1 8890 Bu 2-Br, 5-NMe.sub.3OTf 1 8891 Bu 2-Br, 5-NMe.sub.3I 1 8892 Bu 2-F, 4-Br 1 8893 Bu 2-NO.sub.2, 4-Br 1 8894 Bu 2-NH.sub.2, 4-Br 1 8895 Bu 2-NHMe, 4-Br 1 8896 Bu 2-NMe.sub.2, 4-Br 1 8897 Bu 2-NMe.sub.3OTf, 4-Br 1 8898 Bu 2-NMe.sub.3I, 4-Br 1 8899 Bu 2-I, 4-F 1 8900 Bu 2-I, 4-NO.sub.2 1 8901 Bu 2-I, 4-NH.sub.2 1 8902 Bu 2-I, 4-NHMe 1 8903 Bu 2-I, 4-NMe.sub.2 1 8904 Bu 2-I, 4-NMe.sub.3OTf 1 8905 Bu 2-I, 4-NMe.sub.3I 1 8906 Bu 2-F, 4-I 1 8907 Bu 2-NO.sub.2, 4-I 1 8908 Bu 2-NH.sub.2, 4-I 1 8909 Bu 2-NHMe, 4-I 1 8910 Bu 2-NMe.sub.2, 4-I 1 8911 Bu 2-NMe.sub.3OTf, 4-I 1 8912 Bu 2-NMe.sub.3I, 4-I 1 8913 Bu 2-Me, 3-F 1 8914 Bu 2-Me, 3-NO.sub.2 1 8915 Bu 2-Me, 3-NH.sub.2 1 8916 Bu 2-Me, 3-NHMe 1 8917 Bu 2-Me, 3-NMe.sub.2 1 8918 Bu 2-Me, 3-NMe.sub.3OTf 1 8919 Bu 2-Me, 3-NMe.sub.3I 1 8920 Bu 2-Me, 4-F 1 8921 Bu 2-Me, 4-NO.sub.2 1 8922 Bu 2-Me, 4-NH.sub.2 1 8923 Bu 2-Me, 4-NHMe 1 8924 Bu 2-Me, 4-NMe.sub.2 1 8925 Bu 2-Me, 4-NMe.sub.3OTf 1 8926 Bu 2-Me, 4-NMe.sub.3I 1 8927 Bu 2-Me, 5-F 1 8928 Bu 2-Me, 5-NO.sub.2 1 8929 Bu 2-Me, 5-NH.sub.2 1 8930 Bu 2-Me, 5-NHMe 1 8931 Bu 2-Me, 5-NMe.sub.2 1 8932 Bu 2-Me, 5-NMe.sub.3OTf 1 8933 Bu 2-Me, 5-NMe.sub.3I 1 8934 Bu 2-F, 4-Me 1 8935 Bu 2-NO.sub.2, 4-Me 1 8936 Bu 2-NH.sub.2, 4-Me 1 8937 Bu 2-NHMe, 4-Me 1 8938 Bu 2-NMe.sub.2, 4-Me 1 8939 Bu 2-NMe.sub.3, 4-Me 1 8940 Bu 2-NMe.sub.3OTf, 4-Me 1 8941 Bu 2-NMe.sub.3I, 4-Me 1 8942 Bu 2-SnMe.sub.3, 4-F 1 8943 Bu 2-SnMe.sub.3, 5-F 1 8944 Bu 2-F, 4-SnMe.sub.3 1 8945 Bu 2-Br, 6-Cl, 4-F 1 8946 Bu 2-Br, 6-Cl, 4-NO.sub.2 1 8947 Bu 2-Br, 6-Cl, 4-NH.sub.2 1 8948 Bu 2-Br, 6-Cl, 4- 1 NHMe 8949 Bu 2-Br, 6-Cl, 4-NMe.sub.2 1 8950 Bu 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 8951 Bu 2-Br, 6-Cl, 4- 1 NMe.sub.3I 8952 Bu 2-Me, 6-Cl, 4-F 1 8953 Bu 2-SnMe.sub.3, 6-Cl, 4-F 1 8954 Bu 2-Cl, 4-Me 1 8955 Bu 2-Cl, 4-Br 1 8956 Bu 2-Cl, 4-SnMe.sub.3 1 8957 Bu 2-Br, 4-Cl 1 8958 Bu 2-SnMe.sub.3, 4-Cl 1 8959 Bu 2-Me, 4-Cl 1 8960 Bu 2-Br, 4-Br 1 8961 Bu 2-Br, 4-Me 1 8962 Bu 2-Br, 4-SnMe.sub.3 1 8963 Bu 2-SnMe.sub.3, 4-Br 1 8964 Bu 2-Me, 4-Br 1 8965 Bu 2-Me, 4-SnMe.sub.3 1 8966 Bu 2-SnMe.sub.3, 4-Me 1 8967 Bu 2-Me, 4-Me 1 8968 Bu 2-Et, 4-Br 1 8969 Bu 2-Et, 4-SnMe.sub.3 1 8970 Bu 2-Et, 4-Me 1 8971 Bu 2-Me, 4-Me, 6-Me 1 8972 Bu 2-Me, 4-Br, 6-Me 1 8973 Bu 2-Me, 4-SnMe.sub.3, 6- 1 Me 8974 Bu 2-Et, 6-Me 1 8975 Bu 2-Br, 4-i-Pr 1 8976 Bu 2-SnMe.sub.3, 4-i-Pr 1 8977 Bu 2-Me, 4-i-Pr 1 8978 Bu 2-Br, 4-Br, 6-Br 1 8979 Bu 2-Br, 4-Me, 6-Br 1 8980 Bu 2-Br, 4-SnMe.sub.3, 6- 1 Br 8981 Bu 2-SnMe.sub.3, 4-Br, 6- 1 Br 8982 Bu 2-Br, 4-Br, 6-Me 1 8983 Bu 2-Br, 4-CF.sub.3, 6-Br 1 8984 Bu 2-Br, 4-Br, 6-CF.sub.3 1 8985 Bu 2-CF.sub.3, 4-CF.sub.3 1 8986 Bu 2-Cl, 4-CF.sub.3 1 8987 Bu 2-CF.sub.3, 4-Cl 1 8988 Bu 2-Br, 4-CF.sub.3 1 8989 Bu 2-SnMe.sub.3, 4-CF.sub.3 1 8990 Bu 2-Me, 4-CF.sub.3 1 8991 Bu 2-CF.sub.3, 4-Br 1 8992 Bu 2-CF.sub.3, 4-SnMe.sub.3 1 8993 Bu 2-CF.sub.3, 4-Me 1 8994 Bu 2-Br, 4-OH 1 8995 Bu 2-Br, 4-OMe 1 8996 Bu 2-Br, 4-OMeF 1 8997 Bu 2-Br, 4-OCF.sub.3 1 8998 Bu 2-Br, 4-OEtF 1 8999 Bu 2-Br, 4-OPrF 1 9000 Bu 2-OH, 4-Br 1 9001 Bu 2-OMe, 4-Br 1 9002 Bu 2-OMeF, 4-Br 1 9003 Bu 2-OCF.sub.3, 4-Br 1 9004 Bu 2-OEtF, 4-Br 1 9005 Bu 2-OPrF, 4-Br 1 9006 Bu 2-I, 4-OH 1 9007 Bu 2-I, 4-OMe 1

9008 Bu 2-I, 4-OMeF 1 9009 Bu 2-I, 4-OCF.sub.3 1 9010 Bu 2-I, 4-OEtF 1 9011 Bu 2-I, 4-OPrF 1 9012 Bu 2-OH, 4-I 1 9013 Bu 2-OMe, 4-I 1 9014 Bu 2-OMeF, 4-I 1 9015 Bu 2-OCF.sub.3, 4-I 1 9016 Bu 2-OEtF, 4-I 1 9017 Bu 2-OPrF, 4-I 1 9018 Bu 2-SnMe.sub.3, 4-OH 1 9019 Bu 2-SnMe.sub.3, 4-OMe 1 9020 Bu 2-SnMe.sub.3, 4-OMeF 1 9021 Bu 2-SnMe.sub.3, 4-OCF.sub.3 1 9022 Bu 2-SnMe.sub.3, 4-OEtF 1 9023 Bu 2-SnMe.sub.3, 4-OPrF 1 9024 Bu 2-OH, 4-SnMe.sub.3 1 9025 Bu 2-OMe, 4-SnMe.sub.3 1 9026 Bu 2-OMeF, 4-SnMe.sub.3 1 9027 Bu 2-OCF.sub.3, 4-SnMe.sub.3 1 9028 Bu 2-OEtF, 4-SnMe.sub.3 1 9029 Bu 2-OPrF, 4-SnMe.sub.3 1 9030 Bu H 2 9031 Bu 2-t-Bu 2 9032 Bu 2-Br 2 9033 Bu 3-Br 2 9034 Bu 4-Br 2 9035 Bu 2-I 2 9036 Bu 3-I 2 9037 Bu 4-I 2 9038 Bu 2-SnMe.sub.3 2 9039 Bu 3-SnMe.sub.3 2 9040 Bu 4-SnMe.sub.3 2 9041 Bu 2-Me 2 9042 Bu 3-Me 2 9043 Bu 4-Me 2 9044 Bu 2-OH 2 9045 Bu 3-OH 2 9046 Bu 4-OH 2 9047 Bu 2-OMe 2 9048 Bu 3-OMe 2 9049 Bu 4-OMe 2 9050 Bu 2-OMeF 2 9051 Bu 3-OMeF 2 9052 Bu 4-OMeF 2 9053 Bu 2-OCF.sub.3 2 9054 Bu 3-OCF.sub.3 2 9055 Bu 4-OCF.sub.3 2 9056 Bu 2-OEtF 2 9057 Bu 3-OEtF 2 9058 Bu 4-OEtF 2 9059 Bu 2-OPrF 2 9060 Bu 3-OPrF 2 9061 Bu 4-OPrF 2 9062 Bu 2-SH 2 9063 Bu 3-SH 2 9064 Bu 4-SH 2 9065 Bu 2-SMe 2 9066 Bu 3-SMe 2 9067 Bu 4-SMe 2 9068 Bu 2-SMeF 2 9069 Bu 3-SMeF 2 9070 Bu 4-SMeF 2 9071 Bu 2-SCF.sub.3 2 9072 Bu 3-SCF.sub.3 2 9073 Bu 4-SCF.sub.3 2 9074 Bu 2-SEtF 2 9075 Bu 3-SEtF 2 9076 Bu 4-SEtF 2 9077 Bu 2-SPrF 2 9078 Bu 3-SPrF 2 9079 Bu 4-SPrF 2 9080 Bu 2-OMe, 4-OMe 2 9081 Bu 2-Me, 5-OH 2 9082 Bu 2-Me, 5-OMe 2 9083 Bu 2-Me, 5-OMeF 2 9084 Bu 2-Me, 5-OEtF 2 9085 Bu 2-Me, 5-OPrF 2 9086 Bu 2-Me, 4-OH 2 9087 Bu 2-Me, 4-OMeF 2 9088 Bu 2-Me, 4-OCF.sub.3 2 9089 Bu 2-Me, 4-OEtF 2 9090 Bu 2-Me, 4-OPrF 2 9091 Bu 2-OH, 4-Me 2 9092 Bu 2-OMe, 4-Me 2 9093 Bu 2-OMeF, 4-Me 2 9094 Bu 2-OCF.sub.3, 4-Me 2 9095 Bu 2-OEtF, 4-Me 2 9096 Bu 2-OPrF, 4-Me 2 9097 Bu 2-Cl, 4-OH 2 9098 Bu 2-Cl, 4-OMeF 2 9099 Bu 2-Cl, 4-OCF.sub.3 2 9100 Bu 2-Cl, 4-OEtF 2 9101 Bu 2-Cl, 4-OPrF 2 9102 Bu 2-F, 4-F 2 9103 Bu 2-Cl, 4-F 2 9104 Bu 2-Cl, 4-NO.sub.2 2 9105 Bu 2-Cl, 4-NH.sub.2 2 9106 Bu 2-Cl, 4-NHMe 2 9107 Bu 2-Cl, 4-NMe.sub.2 2 9108 Bu 2-Cl, 4-NMe.sub.3OTf 2 9109 Bu 2-Cl, 4-NMe.sub.3I 2 9110 Bu 2-Cl, 5-F 2 9111 Bu 2-Cl, 5-NO.sub.2 2 9112 Bu 2-Cl, 5-NH.sub.2 2 9113 Bu 2-Cl, 5-NHMe 2 9114 Bu 2-Cl, 5-NMe.sub.2 2 9115 Bu 2-Cl, 5-NMe.sub.3OTf 2 9116 Bu 2-Cl, 5-NMe.sub.3I 2 9117 Bu 2-F, 4-Cl 2 9118 Bu 2-NO.sub.2, 4-Cl 2 9119 Bu 2-NH.sub.2, 4-Cl 2 9120 Bu 2-NHMe, 4-Cl 2 9121 Bu 2-NMe.sub.2, 4-Cl 2 9122 Bu 2-NMe.sub.3OTf, 4-Cl 2 9123 Bu 2-NMe.sub.3I, 4-Cl 2 9124 Bu 2-F, 5-Cl 2 9125 Bu 2-NO.sub.2, 5-Cl 2 9126 Bu 2-NH.sub.2, 5-Cl 2 9127 Bu 2-NHMe, 5-Cl 2 9128 Bu 2-NMe.sub.2, 5-Cl 2 9129 Bu 2-NMe.sub.3OTf, 5-Cl 2 9130 Bu 2-NMe.sub.3I, 5-Cl 2 9131 Bu 2-Br, 4-F 2 9132 Bu 2-Br, 4-NO.sub.2 2 9133 Bu 2-Br, 4-NH.sub.2 2 9134 Bu 2-Br, 4-NHMe 2 9135 Bu 2-Br, 4-NMe.sub.2 2 9136 Bu 2-Br, 4-NMe.sub.3OTf 2 9137 Bu 2-Br, 4-NMe.sub.3I 2 9138 Bu 2-Br, 5-F 2 9139 Bu 2-Br, 5-NO.sub.2 2 9140 Bu 2-Br, 5-NH.sub.2 2 9141 Bu 2-Br, 5-NHMe 2 9142 Bu 2-Br, 5-NMe.sub.2 2 9143 Bu 2-Br, 5-NMe.sub.3OTf 2 9144 Bu 2-Br, 5-NMe.sub.3I 2 9145 Bu 2-F, 4-Br 2 9146 Bu 2-NO.sub.2, 4-Br 2 9147 Bu 2-NH.sub.2, 4-Br 2 9148 Bu 2-NHMe, 4-Br 2 9149 Bu 2-NMe.sub.2, 4-Br 2 9150 Bu 2-NMe.sub.3OTf, 4-Br 2 9151 Bu 2-NMe.sub.3I, 4-Br 2 9152 Bu 2-I, 4-F 2 9153 Bu 2-I, 4-NO.sub.2 2 9154 Bu 2-I, 4-NH.sub.2 2 9155 Bu 2-I, 4-NHMe 2 9156 Bu 2-I, 4-NMe.sub.2 2 9157 Bu 2-I, 4-NMe.sub.3OTf 2 9158 Bu 2-I, 4-NMe.sub.3I 2 9159 Bu 2-F, 4-I 2 9160 Bu 2-NO.sub.2, 4-I 2 9161 Bu 2-NH.sub.2, 4-I 2 9162 Bu 2-NHMe, 4-I 2 9163 Bu 2-NMe.sub.2, 4-I 2 9164 Bu 2-NMe.sub.3OTf, 4-I 2 9165 Bu 2-NMe.sub.3I, 4-I 2 9166 Bu 2-Me, 3-F 2 9167 Bu 2-Me, 3-NO.sub.2 2 9168 Bu 2-Me, 3-NH.sub.2 2 9169 Bu 2-Me, 3-NHMe 2 9170 Bu 2-Me, 3-NMe.sub.2 2 9171 Bu 2-Me, 3-NMe.sub.3OTf 2 9172 Bu 2-Me, 3-NMe.sub.3I 2 9173 Bu 2-Me, 4-F 2 9174 Bu 2-Me, 4-NO.sub.2 2 9175 Bu 2-Me, 4-NH.sub.2 2 9176 Bu 2-Me, 4-NHMe 2 9177 Bu 2-Me, 4-NMe.sub.2 2 9178 Bu 2-Me, 4-NMe.sub.3OTf 2 9179 Bu 2-Me, 4-NMe.sub.3I 2 9180 Bu 2-Me, 5-F 2 9181 Bu 2-Me, 5-NO.sub.2 2 9182 Bu 2-Me, 5-NH.sub.2 2 9183 Bu 2-Me, 5-NHMe 2 9184 Bu 2-Me, 5-NMe.sub.2 2 9185 Bu 2-Me, 5-NMe.sub.3OTf 2 9186 Bu 2-Me, 5-NMe.sub.3I 2 9187 Bu 2-F, 4-Me 2 9188 Bu 2-NO.sub.2, 4-Me 2 9189 Bu 2-NH.sub.2, 4-Me 2 9190 Bu 2-NHMe, 4-Me 2 9191 Bu 2-NMe.sub.2, 4-Me 2 9192 Bu 2-NMe.sub.3, 4-Me 2 9193 Bu 2-NMe.sub.3OTf, 4-Me 2 9194 Bu 2-NMe.sub.3I, 4-Me 2 9195 Bu 2-SnMe.sub.3, 4-F 2 9196 Bu 2-SnMe.sub.3, 5-F 2 9197 Bu 2-F, 4-SnMe.sub.3 2 9198 Bu 2-Br, 6-Cl, 4-F 2 9199 Bu 2-Br, 6-Cl, 4-NO.sub.2 2 9200 Bu 2-Br, 6-Cl, 4-NH.sub.2 2 9201 Bu 2-Br, 6-Cl, 4- 2 NHMe 9202 Bu 2-Br, 6-Cl, 4-NMe.sub.2 2 9203 Bu 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 9204 Bu 2-Br, 6-Cl, 4- 2 NMe.sub.3I 9205 Bu 2-Me, 6-Cl, 4-F 2 9206 Bu 2-SnMe.sub.3, 6-Cl, 4-F 2 9207 Bu 2-Cl, 4-Me 2 9208 Bu 2-Cl, 4-Br 2 9209 Bu 2-Cl, 4-SnMe.sub.3 2 9210 Bu 2-Br, 4-Cl 2 9211 Bu 2-SnMe.sub.3, 4-Cl 2 9212 Bu 2-Me, 4-Cl 2 9213 Bu 2-Br, 4-Br 2 9214 Bu 2-Br, 4-Me 2 9215 Bu 2-Br, 4-SnMe.sub.3 2 9216 Bu 2-SnMe.sub.3, 4-Br 2 9217 Bu 2-Me, 4-Br 2 9218 Bu 2-Me, 4-SnMe.sub.3 2 9219 Bu 2-SnMe.sub.3, 4-Me 2 9220 Bu 2-Me, 4-Me 2 9221 Bu 2-Et, 4-Br 2 9222 Bu 2-Et, 4-SnMe.sub.3 2 9223 Bu 2-Et, 4-Me 2 9224 Bu 2-Me, 4-Br, 6-Me 2 9225 Bu 2-Me, 4-SnMe.sub.3, 6- 2 Me 9226 Bu 2-Et, 6-Me 2 9227 Bu 2-SnMe.sub.3, 4-i-Pr 2 9228 Bu 2-Me, 4-i-Pr 2 9229 Bu 2-Br, 4-Br, 6-Br 2 9230 Bu 2-Br, 4-Me, 6-Br 2 9231 Bu 2-Br, 4-SnMe.sub.3, 6- 2 Br 9232 Bu 2-SnMe.sub.3, 4-Br, 6- 2 Br 9233 Bu 2-Br, 4-Br, 6-Me 2 9234 Bu 2-Br, 4-CF.sub.3, 6-Br 2 9235 Bu 2-Br, 4-Br, 6-CF.sub.3 2 9236 Bu 2-CF.sub.3, 4-CF.sub.3 2 9237 Bu 2-Cl, 4-CF.sub.3 2 9238 Bu 2-CF.sub.3, 4-Cl 2 9239 Bu 2-Br, 4-CF.sub.3 2 9240 Bu 2-SnMe.sub.3, 4-CF.sub.3 2 9241 Bu 2-Me, 4-CF.sub.3 2 9242 Bu 2-CF.sub.3, 4-Br 2 9243 Bu 2-CF.sub.3, 4-SnMe.sub.3 2 9244 Bu 2-CF.sub.3, 4-Me 2 9245 Bu 2-Br, 4-OH 2 9246 Bu 2-Br, 4-OMe 2 9247 Bu 2-Br, 4-OMeF 2 9248 Bu 2-Br, 4-OCF.sub.3 2 9249 Bu 2-Br, 4-OEtF 2 9250 Bu 2-Br, 4-OPrF 2 9251 Bu 2-OH, 4-Br 2 9252 Bu 2-OMe, 4-Br 2

9253 Bu 2-OMeF, 4-Br 2 9254 Bu 2-OCF.sub.3, 4-Br 2 9255 Bu 2-OEtF, 4-Br 2 9256 Bu 2-OPrF, 4-Br 2 9257 Bu 2-I, 4-OH 2 9258 Bu 2-I, 4-OMe 2 9259 Bu 2-I, 4-OMeF 2 9260 Bu 2-I, 4-OCF.sub.3 2 9261 Bu 2-I, 4-OEtF 2 9262 Bu 2-I, 4-OPrF 2 9263 Bu 2-OH, 4-I 2 9264 Bu 2-OMe, 4-I 2 9265 Bu 2-OMeF, 4-I 2 9266 Bu 2-OCF.sub.3, 4-I 2 9267 Bu 2-OEtF, 4-I 2 9268 Bu 2-OPrF, 4-I 2 9269 Bu 2-SnMe.sub.3, 4-OH 2 9270 Bu 2-SnMe.sub.3, 4-OMe 2 9271 Bu 2-SnMe.sub.3, 4-OMeF 2 9272 Bu 2-SnMe.sub.3, 4-OCF.sub.3 2 9273 Bu 2-SnMe.sub.3, 4-OEtF 2 9274 Bu 2-SnMe.sub.3, 4-OPrF 2 9275 Bu 2-OH, 4-SnMe.sub.3 2 9276 Bu 2-OMe, 4-SnMe.sub.3 2 9277 Bu 2-OMeF, 4-SnMe.sub.3 2 9278 Bu 2-OCF.sub.3, 4-SnMe.sub.3 2 9279 Bu 2-OEtF, 4-SnMe.sub.3 2 9280 Bu 2-OPrF, 4-SnMe.sub.3 2 9281 Bu--F H 1 9282 Bu--F 2-t-Bu 1 9283 Bu--F 2-Br 1 9284 Bu--F 3-Br 1 9285 Bu--F 4-Br 1 9286 Bu--F 2-I 1 9287 Bu--F 3-I 1 9288 Bu--F 4-I 1 9289 Bu--F 2-SnMe.sub.3 1 9290 Bu--F 3-SnMe.sub.3 1 9291 Bu--F 4-SnMe.sub.3 1 9292 Bu--F 2-Me 1 9293 Bu--F 3-Me 1 9294 Bu--F 4-Me 1 9295 Bu--F 2-OH 1 9296 Bu--F 3-OH 1 9297 Bu--F 4-OH 1 9298 Bu--F 2-OMe 1 9299 Bu--F 3-OMe 1 9300 Bu--F 4-OMe 1 9301 Bu--F 2-OMeF 1 9302 Bu--F 3-OMeF 1 9303 Bu--F 4-OMeF 1 9304 Bu--F 2-OCF.sub.3 1 9305 Bu--F 3-OCF.sub.3 1 9306 Bu--F 4-OCF.sub.3 1 9307 Bu--F 2-OEtF 1 9308 Bu--F 3-OEtF 1 9309 Bu--F 4-OEtF 1 9310 Bu--F 2-OPrF 1 9311 Bu--F 3-OPrF 1 9312 Bu--F 4-OPrF 1 9313 Bu--F 2-SH 1 9314 Bu--F 3-SH 1 9315 Bu--F 4-SH 1 9316 Bu--F 2-SMe 1 9317 Bu--F 3-SMe 1 9318 Bu--F 4-SMe 1 9319 Bu--F 2-SMeF 1 9320 Bu--F 3-SMeF 1 9321 Bu--F 4-SMeF 1 9322 Bu--F 2-SCF.sub.3 1 9323 Bu--F 3-SCF.sub.3 1 9324 Bu--F 4-SCF.sub.3 1 9325 Bu--F 2-SEtF 1 9326 Bu--F 3-SEtF 1 9327 Bu--F 4-SEtF 1 9328 Bu--F 2-SPrF 1 9329 Bu--F 3-SPrF 1 9330 Bu--F 4-SPrF 1 9331 Bu--F 2-OMe, 4-OMe 1 9332 Bu--F 2-Me, 5-OH 1 9333 Bu--F 2-Me, 5-OMe 1 9334 Bu--F 2-Me, 5-OMeF 1 9335 Bu--F 2-Me, 5-OEtF 1 9336 Bu--F 2-Me, 5-OPrF 1 9337 Bu--F 2-Me, 4-OH 1 9338 Bu--F 2-Me, 4-OMe 1 9339 Bu--F 2-Me, 4-OMeF 1 9340 Bu--F 2-Me, 4-OCF.sub.3 1 9341 Bu--F 2-Me, 4-OEtF 1 9342 Bu--F 2-Me, 4-OPrF 1 9343 Bu--F 2-OH, 4-Me 1 9344 Bu--F 2-OMe, 4-Me 1 9345 Bu--F 2-OMeF, 4-Me 1 9346 Bu--F 2-OCF.sub.3, 4-Me 1 9347 Bu--F 2-OEtF, 4-Me 1 9348 Bu--F 2-OPrF, 4-Me 1 9349 Bu--F 2-Cl, 4-OH 1 9350 Bu--F 2-Cl, 4-OMe 1 9351 Bu--F 2-Cl, 4-OMeF 1 9352 Bu--F 2-Cl, 4-OCF.sub.3 1 9353 Bu--F 2-Cl, 4-OEtF 1 9354 Bu--F 2-Cl, 4-OPrF 1 9355 Bu--F 2-F, 4-F 1 9356 Bu--F 2-Cl, 4-Cl 1 9357 Bu--F 2-Cl, 4-F 1 9358 Bu--F 2-Cl, 4-NO.sub.2 1 9359 Bu--F 2-Cl, 4-NH.sub.2 1 9360 Bu--F 2-Cl, 4-NHMe 1 9361 Bu--F 2-Cl, 4-NMe.sub.2 1 9362 Bu--F 2-Cl, 4-NMe.sub.3OTf 1 9363 Bu--F 2-Cl, 4-NMe.sub.3I 1 9364 Bu--F 2-Cl, 5-F 1 9365 Bu--F 2-Cl, 5-NO.sub.2 1 9366 Bu--F 2-Cl, 5-NH.sub.2 1 9367 Bu--F 2-Cl, 5-NHMe 1 9368 Bu--F 2-Cl, 5-NMe.sub.2 1 9369 Bu--F 2-Cl, 5-NMe.sub.3OTf 1 9370 Bu--F 2-Cl, 5-NMe.sub.3I 1 9371 Bu--F 2-F, 4-Cl 1 9372 Bu--F 2-NO.sub.2, 4-Cl 1 9373 Bu--F 2-NH.sub.2, 4-Cl 1 9374 Bu--F 2-NHMe, 4-Cl 1 9375 Bu--F 2-NMe.sub.2, 4-Cl 1 9376 Bu--F 2-NMe.sub.3OTf, 4-Cl 1 9377 Bu--F 2-NMe.sub.3I, 4-Cl 1 9378 Bu--F 2-F, 5-Cl 1 9379 Bu--F 2-NO.sub.2, 5-Cl 1 9380 Bu--F 2-NH.sub.2, 5-Cl 1 9381 Bu--F 2-NHMe, 5-Cl 1 9382 Bu--F 2-NMe.sub.2, 5-Cl 1 9383 Bu--F 2-NMe.sub.3OTf, 5-Cl 1 9384 Bu--F 2-NMe.sub.3I, 5-Cl 1 9385 Bu--F 2-Br, 4-F 1 9386 Bu--F 2-Br, 4-NO.sub.2 1 9387 Bu--F 2-Br, 4-NH.sub.2 1 9388 Bu--F 2-Br, 4-NHMe 1 9389 Bu--F 2-Br, 4-NMe.sub.2 1 9390 Bu--F 2-Br, 4-NMe.sub.3OTf 1 9391 Bu--F 2-Br, 4-NMe.sub.3I 1 9392 Bu--F 2-Br, 5-F 1 9393 Bu--F 2-Br, 5-NO.sub.2 1 9394 Bu--F 2-Br, 5-NH.sub.2 1 9395 Bu--F 2-Br, 5-NHMe 1 9396 Bu--F 2-Br, 5-NMe.sub.2 1 9397 Bu--F 2-Br, 5-NMe.sub.3OTf 1 9398 Bu--F 2-Br, 5-NMe.sub.3I 1 9399 Bu--F 2-F, 4-Br 1 9400 Bu--F 2-NO.sub.2, 4-Br 1 9401 Bu--F 2-NH.sub.2, 4-Br 1 9402 Bu--F 2-NHMe, 4-Br 1 9403 Bu--F 2-NMe.sub.2, 4-Br 1 9404 Bu--F 2-NMe.sub.3OTf, 4-Br 1 9405 Bu--F 2-NMe.sub.3I, 4-Br 1 9406 Bu--F 2-I, 4-F 1 9407 Bu--F 2-I, 4-NO.sub.2 1 9408 Bu--F 2-I, 4-NH.sub.2 1 9409 Bu--F 2-I, 4-NHMe 1 9410 Bu--F 2-I, 4-NMe.sub.2 1 9411 Bu--F 2-I, 4-NMe.sub.3OTf 1 9412 Bu--F 2-I, 4-NMe.sub.3I 1 9413 Bu--F 2-F, 4-I 1 9414 Bu--F 2-NO.sub.2, 4-I 1 9415 Bu--F 2-NH.sub.2, 4-I 1 9416 Bu--F 2-NHMe, 4-I 1 9417 Bu--F 2-NMe.sub.2, 4-I 1 9418 Bu--F 2-NMe.sub.3OTf, 4-I 1 9419 Bu--F 2-NMe.sub.3I, 4-I 1 9420 Bu--F 2-Me, 3-F 1 9421 Bu--F 2-Me, 3-NO.sub.2 1 9422 Bu--F 2-Me, 3-NH.sub.2 1 9423 Bu--F 2-Me, 3-NHMe 1 9424 Bu--F 2-Me, 3-NMe.sub.2 1 9425 Bu--F 2-Me, 3-NMe.sub.3OTf 1 9426 Bu--F 2-Me, 3-NMe.sub.3I 1 9427 Bu--F 2-Me, 4-F 1 9428 Bu--F 2-Me, 4-NO.sub.2 1 9429 Bu--F 2-Me, 4-NH.sub.2 1 9430 Bu--F 2-Me, 4-NHMe 1 9431 Bu--F 2-Me, 4-NMe.sub.2 1 9432 Bu--F 2-Me, 4-NMe.sub.3OTf 1 9433 Bu--F 2-Me, 4-NMe.sub.3I 1 9434 Bu--F 2-Me, 5-F 1 9435 Bu--F 2-Me, 5-NO.sub.2 1 9436 Bu--F 2-Me, 5-NH.sub.2 1 9437 Bu--F 2-Me, 5-NHMe 1 9438 Bu--F 2-Me, 5-NMe.sub.2 1 9439 Bu--F 2-Me, 5-NMe.sub.3OTf 1 9440 Bu--F 2-Me, 5-NMe.sub.3I 1 9441 Bu--F 2-F, 4-Me 1 9442 Bu--F 2-NO.sub.2, 4-Me 1 9443 Bu--F 2-NH.sub.2, 4-Me 1 9444 Bu--F 2-NHMe, 4-Me 1 9445 Bu--F 2-NMe.sub.2, 4-Me 1 9446 Bu--F 2-NMe.sub.3, 4-Me 1 9447 Bu--F 2-NMe.sub.3OTf, 4-Me 1 9448 Bu--F 2-NMe.sub.3I, 4-Me 1 9449 Bu--F 2-SnMe.sub.3, 4-F 1 9450 Bu--F 2-SnMe.sub.3, 5-F 1 9451 Bu--F 2-F, 4-SnMe.sub.3 1 9452 Bu--F 2-Br, 6-Cl, 4-F 1 9453 Bu--F 2-Br, 6-Cl, 4-NO.sub.2 1 9454 Bu--F 2-Br, 6-Cl, 4-NH.sub.2 1 9455 Bu--F 2-Br, 6-Cl, 4- 1 NHMe 9456 Bu--F 2-Br, 6-Cl, 4-NMe.sub.2 1 9457 Bu--F 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 9458 Bu--F 2-Br, 6-Cl, 4- 1 NMe.sub.3I 9459 Bu--F 2-Me, 6-Cl, 4-F 1 9460 Bu--F 2-SnMe.sub.3, 6-Cl, 4-F 1 9461 Bu--F 2-Cl, 4-Me 1 9462 Bu--F 2-Cl, 4-Br 1 9463 Bu--F 2-Cl, 4-SnMe.sub.3 1 9464 Bu--F 2-Br, 4-Cl 1 9465 Bu--F 2-SnMe.sub.3, 4-Cl 1 9466 Bu--F 2-Me, 4-Cl 1 9467 Bu--F 2-Br, 4-Br 1 9468 Bu--F 2-Br, 4-Me 1 9469 Bu--F 2-Br, 4-SnMe.sub.3 1 9470 Bu--F 2-SnMe.sub.3, 4-Br 1 9471 Bu--F 2-Me, 4-Br 1 9472 Bu--F 2-Me, 4-SnMe.sub.3 1 9473 Bu--F 2-SnMe.sub.3, 4-Me 1 9474 Bu--F 2-Me, 4-Me 1 9475 Bu--F 2-Et, 4-Br 1 9476 Bu--F 2-Et, 4-SnMe.sub.3 1 9477 Bu--F 2-Et, 4-Me 1 9478 Bu--F 2-Me, 4-Me, 6-Me 1 9479 Bu--F 2-Me, 4-Br, 6-Me 1 9480 Bu--F 2-Me, 4-SnMe.sub.3, 6- 1 Me 9481 Bu--F 2-Et, 6-Me 1 9482 Bu--F 2-Br, 4-i-Pr 1 9483 Bu--F 2-SnMe.sub.3, 4-i-Pr 1 9484 Bu--F 2-Me, 4-i-Pr 1 9485 Bu--F 2-Br, 4-Br, 6-Br 1 9486 Bu--F 2-Br, 4-Me, 6-Br 1 9487 Bu--F 2-Br, 4-SnMe.sub.3, 6- 1 Br 9488 Bu--F 2-SnMe.sub.3, 4-Br, 6- 1 Br 9489 Bu--F 2-Br, 4-Br, 6-Me 1 9490 Bu--F 2-Br, 4-CF.sub.3, 6-Br 1 9491 Bu--F 2-Br, 4-Br, 6-CF.sub.3 1 9492 Bu--F 2-CF.sub.3, 4-CF.sub.3 1 9493 Bu--F 2-Cl, 4-CF.sub.3 1 9494 Bu--F 2-CF.sub.3, 4-Cl 1 9495 Bu--F 2-Br, 4-CF.sub.3 1 9496 Bu--F 2-SnMe.sub.3, 4-CF.sub.3 1 9497 Bu--F 2-Me, 4-CF.sub.3 1

9498 Bu--F 2-CF.sub.3, 4-Br 1 9499 Bu--F 2-CF.sub.3, 4-SnMe.sub.3 1 9500 Bu--F 2-CF.sub.3, 4-Me 1 9501 Bu--F 2-Br, 4-OH 1 9502 Bu--F 2-Br, 4-OMe 1 9503 Bu--F 2-Br, 4-OMeF 1 9504 Bu--F 2-Br, 4-OCF.sub.3 1 9505 Bu--F 2-Br, 4-OEtF 1 9506 Bu--F 2-Br, 4-OPrF 1 9507 Bu--F 2-OH, 4-Br 1 9508 Bu--F 2-OMe, 4-Br 1 9509 Bu--F 2-OMeF, 4-Br 1 9510 Bu--F 2-OCF.sub.3, 4-Br 1 9511 Bu--F 2-OEtF, 4-Br 1 9512 Bu--F 2-OPrF, 4-Br 1 9513 Bu--F 2-I, 4-OH 1 9514 Bu--F 2-I, 4-OMe 1 9515 Bu--F 2-I, 4-OMeF 1 9516 Bu--F 2-I, 4-OCF.sub.3 1 9517 Bu--F 2-I, 4-OEtF 1 9518 Bu--F 2 I, 4-OPrF 1 9519 Bu--F 2-OH, 4-I 1 9520 Bu--F 2-OMe, 4-I 1 9521 Bu--F 2-OMeF, 4-I 1 9522 Bu--F 2-OCF.sub.3, 4-I 1 9523 Bu--F 2-OEtF, 4-I 1 9524 Bu--F 2-OPrF, 4-I 1 9525 Bu--F 2-SnMe.sub.3, 4-OH 1 9526 Bu--F 2-SnMe.sub.3, 4-OMe 1 9527 Bu--F 2-SnMe.sub.3, 4-OMeF 1 9528 Bu--F 2-SnMe.sub.3, 4-OCF.sub.3 1 9529 Bu--F 2-SnMe.sub.3, 4-OEtF 1 9530 Bu--F 2-SnMe.sub.3, 4-OPrF 1 9531 Bu--F 2-OH, 4-SnMe.sub.3 1 9532 Bu--F 2-OMe, 4-SnMe.sub.3 1 9533 Bu--F 2-OMeF, 4-SnMe.sub.3 1 9534 Bu--F 2-OCF.sub.3, 4-SnMe.sub.3 1 9535 Bu--F 2-OEtF, 4-SnMe.sub.3 1 9536 Bu--F 2-OPrF, 4-SnMe.sub.3 1 9537 Bu--F H 2 9538 Bu--F 2-t-Bu 2 9539 Bu--F 2-Br 2 9540 Bu--F 3-Br 2 9541 Bu--F 4-Br 2 9542 Bu--F 2-I 2 9543 Bu--F 3-I 2 9544 Bu--F 4-I 2 9545 Bu--F 2-SnMe.sub.3 2 9546 Bu--F 3-SnMe.sub.3 2 9547 Bu--F 4-SnMe.sub.3 2 9548 Bu--F 2-Me 2 9549 Bu--F 3-Me 2 9550 Bu--F 4-Me 2 9551 Bu--F 2-OH 2 9552 Bu--F 3-OH 2 9553 Bu--F 4-OH 2 9554 Bu--F 2-OMe 2 9555 Bu--F 3-OMe 2 9556 Bu--F 4-OMe 2 9557 Bu--F 2-OMeF 2 9558 Bu--F 3-OMeF 2 9559 Bu--F 4-OMeF 2 9560 Bu--F 2-OCF.sub.3 2 9561 Bu--F 3-OCF.sub.3 2 9562 Bu--F 4-OCF.sub.3 2 9563 Bu--F 2-OEtF 2 9564 Bu--F 3-OEtF 2 9565 Bu--F 4-OEtF 2 9566 Bu--F 2-OPrF 2 9567 Bu--F 3-OPrF 2 9568 Bu--F 4-OPrF 2 9569 Bu--F 2-SH 2 9570 Bu--F 3-SH 2 9571 Bu--F 4-SH 2 9572 Bu--F 2-SMe 2 9573 Bu--F 3-SMe 2 9574 Bu--F 4-SMe 2 9575 Bu--F 2-SMeF 2 9576 Bu--F 3-SMeF 2 9577 Bu--F 4-SMeF 2 9578 Bu--F 2-SCF.sub.3 2 9579 Bu--F 3-SCF.sub.3 2 9580 Bu--F 4-SCF.sub.3 2 9581 Bu--F 2-SEtF 2 9582 Bu--F 3-SEtF 2 9583 Bu--F 4-SEtF 2 9584 Bu--F 2-SPrF 2 9585 Bu--F 3-SPrF 2 9586 Bu--F 4-SPrF 2 9587 Bu--F 2-OMe, 4-OMe 2 9588 Bu--F 2-Me, 5-OH 2 9589 Bu--F 2-Me, 5-OMe 2 9590 Bu--F 2-Me, 5-OMeF 2 9591 Bu--F 2-Me, 5-OEtF 2 9592 Bu--F 2-Me, 5-OPrF 2 9593 Bu--F 2-Me, 4-OH 2 9594 Bu--F 2-Me, 4-OMe 2 9595 Bu--F 2-Me, 4-OMeF 2 9596 Bu--F 2-Me, 4-OCF.sub.3 2 9597 Bu--F 2-Me, 4-OEtF 2 9598 Bu--F 2-Me, 4-OPrF 2 9599 Bu--F 2-OH, 4-Me 2 9600 Bu--F 2-OMe, 4-Me 2 9601 Bu--F 2-OMeF, 4-Me 2 9602 Bu--F 2-OCF.sub.3, 4-Me 2 9603 Bu--F 2-OEtF, 4-Me 2 9604 Bu--F 2-OPrF, 4-Me 2 9605 Bu--F 2-Cl, 4-OH 2 9606 Bu--F 2-Cl, 4-OMe 2 9607 Bu--F 2-Cl, 4-OMeF 2 9608 Bu--F 2-Cl, 4-OCF.sub.3 2 9609 Bu--F 2-Cl, 4-OEtF 2 9610 Bu--F 2-Cl, 4-OPrF 2 9611 Bu--F 2-F, 4-F 2 9612 Bu--F 2-Cl, 4-Cl 2 9613 Bu--F 2-Cl, 4-F 2 9614 Bu--F 2-Cl, 4-NO.sub.2 2 9615 Bu--F 2-Cl, 4-NH.sub.2 2 9616 Bu--F 2-Cl, 4-NHMe 2 9617 Bu--F 2-Cl, 4-NMe.sub.2 2 9618 Bu--F 2-Cl, 4-NMe.sub.3OTf 2 9619 Bu--F 2-Cl, 4-NMe.sub.3I 2 9620 Bu--F 2-Cl, 5-F 2 9621 Bu--F 2-Cl, 5-NO.sub.2 2 9622 Bu--F 2-Cl, 5-NH.sub.2 2 9623 Bu--F 2-Cl, 5-NHMe 2 9624 Bu--F 2-Cl, 5-NMe.sub.2 2 9625 Bu--F 2-Cl, 5-NMe.sub.3OTf 2 9626 Bu--F 2-Cl, 5-NMe.sub.3I 2 9627 Bu--F 2-F, 4-Cl 2 9628 Bu--F 2-NO.sub.2, 4-Cl 2 9629 Bu--F 2-NH.sub.2, 4-Cl 2 9630 Bu--F 2-NHMe, 4-Cl 2 9631 Bu--F 2-NMe.sub.2, 4-Cl 2 9632 Bu--F 2-NMe.sub.3OTf, 4-Cl 2 9633 Bu--F 2-NMe.sub.3I, 4-Cl 2 9634 Bu--F 2-F, 5-Cl 2 9635 Bu--F 2-NO.sub.2, 5-Cl 2 9636 Bu--F 2-NH.sub.2, 5-Cl 2 9637 Bu--F 2-NHMe, 5-Cl 2 9638 Bu--F 2-NMe.sub.2, 5-Cl 2 9639 Bu--F 2-NMe.sub.3OTf, 5-Cl 2 9640 Bu--F 2-NMe.sub.3I, 5-Cl 2 9641 Bu--F 2-Br, 4-F 2 9642 Bu--F 2-Br, 4-NO.sub.2 2 9643 Bu--F 2-Br, 4-NH.sub.2 2 9644 Bu--F 2-Br, 4-NHMe 2 9645 Bu--F 2-Br, 4-NMe.sub.2 2 9646 Bu--F 2-Br, 4-NMe.sub.3OTf 2 9647 Bu--F 2-Br, 4-NMe.sub.3I 2 9648 Bu--F 2-Br, 5-F 2 9649 Bu--F 2-Br, 5-NO.sub.2 2 9650 Bu--F 2-Br, 5-NH.sub.2 2 9651 Bu--F 2-Br, 5-NHMe 2 9652 Bu--F 2-Br, 5-NMe.sub.2 2 9653 Bu--F 2-Br, 5-NMe.sub.3OTf 2 9654 Bu--F 2-Br, 5-NMe.sub.3I 2 9655 Bu--F 2-F, 4-Br 2 9656 Bu--F 2-NO.sub.2, 4-Br 2 9657 Bu--F 2-NH.sub.2, 4-Br 2 9658 Bu--F 2-NHMe, 4-Br 2 9659 Bu--F 2-NMe.sub.2, 4-Br 2 9660 Bu--F 2-NMe.sub.3OTf, 4-Br 2 9661 Bu--F 2-NMe.sub.3I, 4-Br 2 9662 Bu--F 2-I, 4-F 2 9663 Bu--F 2-I, 4-NO.sub.2 2 9664 Bu--F 2-I, 4-NH.sub.2 2 9665 Bu--F 2-I, 4-NHMe 2 9666 Bu--F 2-I, 4-NMe.sub.2 2 9667 Bu--F 2-I, 4-NMe.sub.3OTf 2 9668 Bu--F 2-I, 4-NMe.sub.3I 2 9669 Bu--F 2-F, 4-I 2 9670 Bu--F 2-NO.sub.2, 4-I 2 9671 Bu--F 2-NH.sub.2, 4-I 2 9672 Bu--F 2-NHMe, 4-I 2 9673 Bu--F 2-NMe.sub.2, 4-I 2 9674 Bu--F 2-NMe.sub.3OTf, 4-I 2 9675 Bu--F 2-NMe.sub.3I, 4-I 2 9676 Bu--F 2-Me, 3-F 2 9677 Bu--F 2-Me, 3-NO.sub.2 2 9678 Bu--F 2-Me, 3-NH.sub.2 2 9679 Bu--F 2-Me, 3-NHMe 2 9680 Bu--F 2-Me, 3-NMe.sub.2 2 9681 Bu--F 2-Me, 3-NMe.sub.3OTf 2 9682 Bu--F 2-Me, 3-NMe.sub.3I 2 9683 Bu--F 2-Me, 4-F 2 9684 Bu--F 2-Me, 4-NO.sub.2 2 9685 Bu--F 2-Me, 4-NH.sub.2 2 9686 Bu--F 2-Me, 4-NHMe 2 9687 Bu--F 2-Me, 4-NMe.sub.2 2 9688 Bu--F 2-Me, 4-NMe.sub.3OTf 2 9689 Bu--F 2-Me, 4-NMe.sub.3I 2 9690 Bu--F 2-Me, 5-F 2 9691 Bu--F 2-Me, 5-NO.sub.2 2 9692 Bu--F 2-Me, 5-NH.sub.2 2 9693 Bu--F 2-Me, 5-NHMe 2 9694 Bu--F 2-Me, 5-NMe.sub.2 2 9695 Bu--F 2-Me, 5-NMe.sub.3OTf 2 9696 Bu--F 2-Me, 5-NMe.sub.3I 2 9697 Bu--F 2-F, 4-Me 2 9698 Bu--F 2-NO.sub.2, 4-Me 2 9699 Bu--F 2-NH.sub.2, 4-Me 2 9700 Bu--F 2-NHMe, 4-Me 2 9701 Bu--F 2-NMe.sub.2, 4-Me 2 9702 Bu--F 2-NMe.sub.3, 4-Me 2 9703 Bu--F 2-NMe.sub.3OTf, 4-Me 2 9704 Bu--F 2-NMe.sub.3I, 4-Me 2 9705 Bu--F 2-SnMe.sub.3, 4-F 2 9706 Bu--F 2-SnMe.sub.3, 5-F 2 9707 Bu--F 2-F, 4-SnMe.sub.3 2 9708 Bu--F 2-Br, 6-Cl, 4-F 2 9709 Bu--F 2-Br, 6-Cl, 4-NO.sub.2 2 9710 Bu--F 2-Br, 6-Cl, 4-NH.sub.2 2 9711 Bu--F 2-Br, 6-Cl, 4- 2 NHMe 9712 Bu--F 2-Br, 6-Cl, 4-NMe.sub.2 2 9713 Bu--F 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 9714 Bu--F 2-Br, 6-Cl, 4- 2 NMe.sub.3I 9715 Bu--F 2-Me, 6-Cl, 4-F 2 9716 Bu--F 2-SnMe.sub.3, 6-Cl, 4-F 2 9717 Bu--F 2-Cl, 4-Me 2 9718 Bu--F 2-Cl, 4-Br 2 9719 Bu--F 2-Cl, 4-SnMe.sub.3 2 9720 Bu--F 2-Br, 4-Cl 2 9721 Bu--F 2-SnMe.sub.3, 4-Cl 2 9722 Bu--F 2-Me, 4-Cl 2 9723 Bu--F 2-Br, 4-Br 2 9724 Bu--F 2-Br, 4-Me 2 9725 Bu--F 2-Br, 4-SnMe.sub.3 2 9726 Bu--F 2-SnMe.sub.3, 4-Br 2 9727 Bu--F 2-Me, 4-Br 2 9728 Bu--F 2-Me, 4-SnMe.sub.3 2 9729 Bu--F 2-SnMe.sub.3, 4-Me 2 9730 Bu--F 2-Me, 4-Me 2 9731 Bu--F 2-Et, 4-Br 2 9732 Bu--F 2-Et, 4-SnMe.sub.3 2 9733 Bu--F 2-Et, 4-Me 2 9734 Bu--F 2-Me, 4-Me, 6-Me 2 9735 Bu--F 2-Me, 4-Br, 6-Me 2 9736 Bu--F 2-Me, 4-SnMe.sub.3, 6- 2 Me 9737 Bu--F 2-Et, 6-Me 2 9738 Bu--F 2-Br, 4-i-Pr 2 9739 Bu--F 2-SnMe.sub.3, 4-i-Pr 2 9740 Bu--F 2-Me, 4-i-Pr 2 9741 Bu--F 2-Br, 4-Br, 6-Br 2 9742 Bu--F 2-Br, 4-Me, 6-Br 2 9743 Bu--F 2-Br, 4-SnMe.sub.3, 6- 2 Br

9744 Bu--F 2-SnMe.sub.3, 4-Br, 6- 2 Br 9745 Bu--F 2-Br, 4-Br, 6-Me 2 9746 Bu--F 2-Br, 4-CF.sub.3, 6-Br 2 9747 Bu--F 2-Br, 4-Br, 6-CF.sub.3 2 9748 Bu--F 2-CF.sub.3, 4-CF.sub.3 2 9749 Bu--F 2-Cl, 4-CF.sub.3 2 9750 Bu--F 2-CF.sub.3, 4-Cl 2 9751 Bu--F 2-Br, 4-CF.sub.3 2 9752 Bu--F 2-SnMe.sub.3, 4-CF.sub.3 2 9753 Bu--F 2-Me, 4-CF.sub.3 2 9754 Bu--F 2-CF.sub.3, 4-Br 2 9755 Bu--F 2-CF.sub.3, 4-SnMe.sub.3 2 9756 Bu--F 2-CF.sub.3, 4-Me 2 9757 Bu--F 2-Br, 4-OH 2 9758 Bu--F 2-Br, 4-OMe 2 9759 Bu--F 2-Br, 4-OMeF 2 9760 Bu--F 2-Br, 4-OCF.sub.3 2 9761 Bu--F 2-Br, 4-OEtF 2 9762 Bu--F 2-Br, 4-OPrF 2 9763 Bu--F 2-OH, 4-Br 2 9764 Bu--F 2-OMe, 4-Br 2 9765 Bu--F 2-OMeF, 4-Br 2 9766 Bu--F 2-OCF.sub.3, 4-Br 2 9767 Bu--F 2-OEtF, 4-Br 2 9768 Bu--F 2-OPrF, 4-Br 2 9769 Bu--F 2-I, 4-OH 2 9770 Bu--F 2-I, 4-OMe 2 9771 Bu--F 2-I, 4-OMeF 2 9772 Bu--F 2-I, 4-OCF.sub.3 2 9773 Bu--F 2-I, 4-OEtF 2 9774 Bu--F 2-I, 4-OPrF 2 9775 Bu--F 2-OH, 4-I 2 9776 Bu--F 2-OMe, 4-I 2 9777 Bu--F 2-OMeF, 4-I 2 9778 Bu--F 2-OCF.sub.3, 4-I 2 9779 Bu--F 2-OEtF, 4-I 2 9780 Bu--F 2-OPrF, 4-I 2 9781 Bu--F 2-SnMe.sub.3, 4-OH 2 9782 Bu--F 2-SnMe.sub.3, 4-OMe 2 9783 Bu--F 2-SnMe.sub.3, 4-OMeF 2 9784 Bu--F 2-SnMe.sub.3, 4-OCF.sub.3 2 9785 Bu--F 2-SnMe.sub.3, 4-OEtF 2 9786 Bu--F 2-SnMe.sub.3, 4-OPrF 2 9787 Bu--F 2-OH, 4-SnMe.sub.3 2 9788 Bu--F 2-OMe, 4-SnMe.sub.3 2 9789 Bu--F 2-OMeF, 4-SnMe.sub.3 2 9790 Bu--F 2-OCF.sub.3, 4-SnMe.sub.3 2 9791 Bu--F 2-OEtF, 4-SnMe.sub.3 2 9792 Bu--F 2-OPrF, 4-SnMe.sub.3 2 9793 Pr H 1 9794 Pr 2-t-Bu 1 9795 Pr 2-Br 1 9796 Pr 3-Br 1 9797 Pr 4-Br 1 9798 Pr 2-I 1 9799 Pr 3-I 1 9800 Pr 4-I 1 9801 Pr 2-SnMe.sub.3 1 9802 Pr 3-SnMe.sub.3 1 9803 Pr 4-SnMe.sub.3 1 9804 Pr 2-Me 1 9805 Pr 3-Me 1 9806 Pr 4-Me 1 9807 Pr 2-OH 1 9808 Pr 3-OH 1 9809 Pr 4-OH 1 9810 Pr 2-OMe 1 9811 Pr 3-OMe 1 9812 Pr 4-OMe 1 9813 Pr 2-OMeF 1 9814 Pr 3-OMeF 1 9815 Pr 4-OMeF 1 9816 Pr 2-OCF.sub.3 1 9817 Pr 3-OCF.sub.3 1 9818 Pr 4-OCF.sub.3 1 9819 Pr 2-OEtF 1 9820 Pr 3-OEtF 1 9821 Pr 4-OEtF 1 9822 Pr 2-OPrF 1 9823 Pr 3-OPrF 1 9824 Pr 4-OPrF 1 9825 Pr 2-SH 1 9826 Pr 3-SH 1 9827 Pr 4-SH 1 9828 Pr 2-SMe 1 9829 Pr 3-SMe 1 9830 Pr 4-SMe 1 9831 Pr 2-SMeF 1 9832 Pr 3-SMeF 1 9833 Pr 4-SMeF 1 9834 Pr 2-SCF.sub.3 1 9835 Pr 3-SCF.sub.3 1 9836 Pr 4-SCF.sub.3 1 9837 Pr 2-SEtF 1 9838 Pr 3-SEtF 1 9839 Pr 4-SEtF 1 9840 Pr 2-SPrF 1 9841 Pr 3-SPrF 1 9842 Pr 4-SPrF 1 9843 Pr 2-OMe, 4-OMe 1 9844 Pr 2-Me, 5-OH 1 9845 Pr 2-Me, 5-OMe 1 9846 Pr 2-Me, 5-OMeF 1 9847 Pr 2-Me, 5-OEtF 1 9848 Pr 2-Me, 5-OPrF 1 9849 Pr 2-Me, 4-OH 1 9850 Pr 2-Me, 4-OMe 1 9851 Pr 2-Me, 4-OMeF 1 9852 Pr 2-Me, 4-OCF.sub.3 1 9853 Pr 2-Me, 4-OEtF 1 9854 Pr 2-Me, 4-OPrF 1 9855 Pr 2-OH, 4-Me 1 9856 Pr 2-OMe, 4-Me 1 9857 Pr 2-OMeF, 4-Me 1 9858 Pr 2-OCF.sub.3, 4-Me 1 9859 Pr 2-OEtF, 4-Me 1 9860 Pr 2-OPrF, 4-Me 1 9861 Pr 2-Cl, 4-OH 1 9862 Pr 2-Cl, 4-OMe 1 9863 Pr 2-Cl, 4-OMeF 1 9864 Pr 2-Cl, 4-OCF.sub.3 1 9865 Pr 2-Cl, 4-OEtF 1 9866 Pr 2-Cl, 4-OPrF 1 9867 Pr 2-F, 4-F 1 9868 Pr 2-Cl, 4-Cl 1 9869 Pr 2-Cl, 4-F 1 9870 Pr 2-Cl, 4-NO.sub.2 1 9871 Pr 2-Cl, 4-NH.sub.2 1 9872 Pr 2-Cl, 4-NHMe 1 9873 Pr 2-Cl, 4-NMe.sub.2 1 9874 Pr 2-Cl, 4-NMe.sub.3OTf 1 9875 Pr 2-Cl, 4-NMe.sub.3I 1 9876 Pr 2-Cl, 5-F 1 9877 Pr 2-Cl, 5-NO.sub.2 1 9878 Pr 2-Cl, 5-NH.sub.2 1 9879 Pr 2-Cl, 5-NHMe 1 9880 Pr 2-Cl, 5-NMe.sub.2 1 9881 Pr 2-Cl, 5-NMe.sub.3OTf 1 9882 Pr 2-Cl, 5-NMe.sub.3I 1 9883 Pr 2-F, 4-Cl 1 9884 Pr 2-NO.sub.2, 4-Cl 1 9885 Pr 2-NH.sub.2, 4-Cl 1 9886 Pr 2-NHMe, 4-Cl 1 9887 Pr 2-NMe.sub.2, 4-Cl 1 9888 Pr 2-NMe.sub.3OTf, 4-Cl 1 9889 Pr 2-NMe.sub.3I, 4-Cl 1 9890 Pr 2-F, 5-Cl 1 9891 Pr 2-NO.sub.2, 5-Cl 1 9892 Pr 2-NH.sub.2, 5-Cl 1 9893 Pr 2-NHMe, 5-Cl 1 9894 Pr 2-NMe.sub.2, 5-Cl 1 9895 Pr 2-NMe.sub.3OTf, 5-Cl 1 9896 Pr 2-NMe.sub.3I, 5-Cl 1 9897 Pr 2-Br, 4-F 1 9898 Pr 2-Br, 4-NO.sub.2 1 9899 Pr 2-Br, 4-NH.sub.2 1 9900 Pr 2-Br, 4-NHMe 1 9901 Pr 2-Br, 4-NMe.sub.2 1 9902 Pr 2-Br, 4-NMe.sub.3OTf 1 9903 Pr 2-Br, 4-NMe.sub.3I 1 9904 Pr 2-Br, 5-F 1 9905 Pr 2-Br, 5-NO.sub.2 1 9906 Pr 2-Br, 5-NH.sub.2 1 9907 Pr 2-Br, 5-NHMe 1 9908 Pr 2-Br, 5-NMe.sub.2 1 9909 Pr 2-Br, 5-NMe.sub.3OTf 1 9910 Pr 2-Br, 5-NMe.sub.3I 1 9911 Pr 2-F, 4-Br 1 9912 Pr 2-NO.sub.2, 4-Br 1 9913 Pr 2-NH.sub.2, 4-Br 1 9914 Pr 2-NHMe, 4-Br 1 9915 Pr 2-NMe.sub.2, 4-Br 1 9916 Pr 2-NMe.sub.3OTf, 4-Br 1 9917 Pr 2-NMe.sub.3I, 4-Br 1 9918 Pr 2-I, 4-F 1 9919 Pr 2-I, 4-NO.sub.2 1 9920 Pr 2-I, 4-NH.sub.2 1 9921 Pr 2-I, 4-NHMe 1 9922 Pr 2-I, 4-NMe.sub.2 1 9923 Pr 2-I, 4-NMe.sub.3OTf 1 9924 Pr 2-I, 4-NMe.sub.3I 1 9925 Pr 2-F, 4-I 1 9926 Pr 2-NO.sub.2, 4-I 1 9927 Pr 2-NH.sub.2, 4-I 1 9928 Pr 2-NHMe, 4-I 1 9929 Pr 2-NMe.sub.2, 4-I 1 9930 Pr 2-NMe.sub.3OTf, 4-I 1 9931 Pr 2-NMe.sub.3I, 4-I 1 9932 Pr 2-Me, 3-F 1 9933 Pr 2-Me, 3-NO.sub.2 1 9934 Pr 2-Me, 3-NH.sub.2 1 9935 Pr 2-Me, 3-NHMe 1 9936 Pr 2-Me, 3-NMe.sub.2 1 9937 Pr 2-Me, 3-NMe.sub.3OTf 1 9938 Pr 2-Me, 3-NMe.sub.3I 1 9939 Pr 2-Me, 4-F 1 9940 Pr 2-Me, 4-NO.sub.2 1 9941 Pr 2-Me, 4-NH.sub.2 1 9942 Pr 2-Me, 4-NHMe 1 9943 Pr 2-Me, 4-NMe.sub.2 1 9944 Pr 2-Me, 4-NMe.sub.3OTf 1 9945 Pr 2-Me, 4-NMe.sub.3I 1 9946 Pr 2-Me, 5-F 1 9947 Pr 2-Me, 5-NO.sub.2 1 9948 Pr 2-Me, 5-NH.sub.2 1 9949 Pr 2-Me, 5-NHMe 1 9950 Pr 2-Me, 5-NMe.sub.2 1 9951 Pr 2-Me, 5-NMe.sub.3OTf 1 9952 Pr 2-Me, 5-NMe.sub.3I 1 9953 Pr 2-F, 4-Me 1 9954 Pr 2-NO.sub.2, 4-Me 1 9955 Pr 2-NH.sub.2, 4-Me 1 9956 Pr 2-NHMe, 4-Me 1 9957 Pr 2-NMe.sub.2, 4-Me 1 9958 Pr 2-NMe.sub.3, 4-Me 1 9959 Pr 2-NMe.sub.3OTf, 4-Me 1 9960 Pr 2-NMe.sub.3I, 4-Me 1 9961 Pr 2-SnMe.sub.3, 4-F 1 9962 Pr 2-SnMe.sub.3, 5-F 1 9963 Pr 2-F, 4-SnMe.sub.3 1 9964 Pr 2-Br, 6-Cl, 4-F 1 9965 Pr 2-Br, 6-Cl, 4-NO.sub.2 1 9966 Pr 2-Br, 6-Cl, 4-NH.sub.2 1 9967 Pr 2-Br, 6-Cl, 4- 1 NHMe 9968 Pr 2-Br, 6-Cl, 4-NMe.sub.2 1 9969 Pr 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 9970 Pr 2-Br, 6-Cl, 4- 1 NMe.sub.3I 9971 Pr 2-Me, 6-Cl, 4-F 1 9972 Pr 2-SnMe.sub.3, 6-Cl, 4-F 1 9973 Pr 2-Cl, 4-Me 1 9974 Pr 2-Cl, 4-Br 1 9975 Pr 2-Cl, 4-SnMe.sub.3 1 9976 Pr 2-Br, 4-Cl 1 9977 Pr 2-SnMe.sub.3, 4-Cl 1 9978 Pr 2-Me, 4-Cl 1 9979 Pr 2-Br, 4-Br 1 9980 Pr 2-Br, 4-Me 1 9981 Pr 2-Br, 4-SnMe.sub.3 1 9982 Pr 2-SnMe.sub.3, 4-Br 1 9983 Pr 2-Me, 4-Br 1 9984 Pr 2-Me, 4-SnMe.sub.3 1 9985 Pr 2-SnMe.sub.3, 4-Me 1 9986 Pr 2-Me, 4-Me 1 9987 Pr 2-Et, 4-Br 1 9988 Pr 2-Et, 4-SnMe.sub.3 1 9989 Pr 2-Et, 4-Me 1 9990 Pr 2-Me, 4-Me, 6-Me 1

9991 Pr 2-Me, 4-Br, 6-Me 1 9992 Pr 2-Me, 4-SnMe.sub.3, 6- 1 Me 9993 Pr 2-Et, 6-Me 1 9994 Pr 2-Br, 4-i-Pr 1 9995 Pr 2-SnMe.sub.3, 4-i-Pr 1 9996 Pr 2-Me, 4-i-Pr 1 9997 Pr 2-Br, 4-Br, 6-Br 1 9998 Pr 2-Br, 4-Me, 6-Br 1 9999 Pr 2-Br, 4-SnMe.sub.3, 6- 1 Br 10000 Pr 2-SnMe.sub.3, 4-Br, 6- 1 Br 10001 Pr 2-Br, 4-Br, 6-Me 1 10002 Pr 2-Br, 4-CF.sub.3, 6-Br 1 10003 Pr 2-Br, 4-Br, 6-CF.sub.3 1 10004 Pr 2-CF.sub.3, 4-CF.sub.3 1 10005 Pr 2-Cl, 4-CF.sub.3 1 10006 Pr 2-CF.sub.3, 4-Cl 1 10007 Pr 2-Br, 4-CF.sub.3 1 10008 Pr 2-SnMe.sub.3, 4-CF.sub.3 1 10009 Pr 2-Me, 4-CF.sub.3 1 10010 Pr 2-CF.sub.3, 4-Br 1 10011 Pr 2-CF.sub.3, 4-SnMe.sub.3 1 10012 Pr 2-CF.sub.3, 4-Me 1 10013 Pr 2-Br, 4-OH 1 10014 Pr 2-Br, 4-OMe 1 10015 Pr 2-Br, 4-OMeF 1 10016 Pr 2-Br, 4-OCF.sub.3 1 10017 Pr 2-Br, 4-OEtF 1 10018 Pr 2-Br, 4-OPrF 1 10019 Pr 2-OH, 4-Br 1 10020 Pr 2-OMe, 4-Br 1 10021 Pr 2-OMeF, 4-Br 1 10022 Pr 2-OCF.sub.3, 4-Br 1 10023 Pr 2-OEtF, 4-Br 1 10024 Pr 2-OPrF, 4-Br 1 10025 Pr 2-I, 4-OH 1 10026 Pr 2-I, 4-OMe 1 10027 Pr 2-I, 4-OMeF 1 10028 Pr 2-I, 4-OCF.sub.3 1 10029 Pr 2-I, 4-OEtF 1 10030 Pr 2-I, 4-OPrF 1 10031 Pr 2-OH, 4-I 1 10032 Pr 2-OMe, 4-I 1 10033 Pr 2-OMeF, 4-I 1 10034 Pr 2-OCF.sub.3, 4-I 1 10035 Pr 2-OEtF, 4-I 1 10036 Pr 2-OPrF, 4-I 1 10037 Pr 2-SnMe.sub.3, 4-OH 1 10038 Pr 2-SnMe.sub.3, 4-OMe 1 10039 Pr 2-SnMe.sub.3, 4-OMeF 1 10040 Pr 2-SnMe.sub.3, 4-OCF.sub.3 1 10041 Pr 2-SnMe.sub.3, 4-OEtF 1 10042 Pr 2-SnMe.sub.3, 4-OPrF 1 10043 Pr 2-OH, 4-SnMe.sub.3 1 10044 Pr 2-OMe, 4-SnMe.sub.3 1 10045 Pr 2-OMeF, 4-SnMe.sub.3 1 10046 Pr 2-OCF.sub.3, 4-SnMe.sub.3 1 10047 Pr 2-OEtF, 4-SnMe.sub.3 1 10048 Pr 2-OPrF, 4-SnMe.sub.3 1 10049 Pr H 2 10050 Pr 2-t-Bu 2 10051 Pr 2-Br 2 10052 Pr 3-Br 2 10053 Pr 4-Br 2 10054 Pr 2-I 2 10055 Pr 3-I 2 10056 Pr 4-I 2 10057 Pr 2-SnMe.sub.3 2 10058 Pr 3-SnMe.sub.3 2 10059 Pr 4-SnMe.sub.3 2 10060 Pr 2-Me 2 10061 Pr 3-Me 2 10062 Pr 4-Me 2 10063 Pr 2-OH 2 10064 Pr 3-OH 2 10065 Pr 4-OH 2 10066 Pr 2-OMe 2 10067 Pr 3-OMe 2 10068 Pr 4-OMe 2 10069 Pr 2-OMeF 2 10070 Pr 3-OMeF 2 10071 Pr 4-OMeF 2 10072 Pr 2-OCF.sub.3 2 10073 Pr 3-OCF.sub.3 2 10074 Pr 4-OCF.sub.3 2 10075 Pr 2-OEtF 2 10076 Pr 3-OEtF 2 10077 Pr 4-OEtF 2 10078 Pr 2-OPrF 2 10079 Pr 3-OPrF 2 10080 Pr 4-OPrF 2 10081 Pr 2-SH 2 10082 Pr 3-SH 2 10083 Pr 4-SH 2 10084 Pr 2-SMe 2 10085 Pr 3-SMe 2 10086 Pr 4-SMe 2 10087 Pr 2-SMeF 2 10088 Pr 3-SMeF 2 10089 Pr 4-SMeF 2 10090 Pr 2-SCF.sub.3 2 10091 Pr 3-SCF.sub.3 2 10092 Pr 4-SCF.sub.3 2 10093 Pr 2-SEtF 2 10094 Pr 3-SEtF 2 10095 Pr 4-SEtF 2 10096 Pr 2-SPrF 2 10097 Pr 3-SPrF 2 10098 Pr 4-SPrF 2 10099 Pr 2-OMe, 4-OMe 2 10100 Pr 2-Me, 5-OH 2 10101 Pr 2-Me, 5-OMe 2 10102 Pr 2-Me, 5-OMeF 2 10103 Pr 2-Me, 5-OEtF 2 10104 Pr 2-Me, 5-OPrF 2 10105 Pr 2-Me, 4-OH 2 10106 Pr 2-Me, 4-OMe 2 10107 Pr 2-Me, 4-OMeF 2 10108 Pr 2-Me, 4-OCF.sub.3 2 10109 Pr 2-Me, 4-OEtF 2 10110 Pr 2-Me, 4-OPrF 2 10111 Pr 2-OH, 4-Me 2 10112 Pr 2-OMe, 4-Me 2 10113 Pr 2-OMeF, 4-Me 2 10114 Pr 2-OCF.sub.3, 4-Me 2 10115 Pr 2-OEtF, 4-Me 2 10116 Pr 2-OPrF, 4-Me 2 10117 Pr 2-Cl, 4-OH 2 10118 Pr 2-Cl, 4-OMe 2 10119 Pr 2-Cl, 4-OMeF 2 10120 Pr 2-Cl, 4-OCF.sub.3 2 10121 Pr 2-Cl, 4-OEtF 2 10122 Pr 2-Cl, 4-OPrF 2 10123 Pr 2-F, 4-F 2 10124 Pr 2-Cl, 4-Cl 2 10125 Pr 2-Cl, 4-F 2 10126 Pr 2-Cl, 4-NO.sub.2 2 10127 Pr 2-Cl, 4-NH.sub.2 2 10128 Pr 2-Cl, 4-NHMe 2 10129 Pr 2-Cl, 4-NMe.sub.2 2 10130 Pr 2-Cl, 4-NMe.sub.3OTf 2 10131 Pr 2-Cl, 4-NMe.sub.3I 2 10132 Pr 2-Cl, 5-F 2 10133 Pr 2-Cl, 5-NO.sub.2 2 10134 Pr 2-Cl, 5-NH.sub.2 2 10135 Pr 2-Cl, 5-NHMe 2 10136 Pr 2-Cl, 5-NMe.sub.2 2 10137 Pr 2-Cl, 5-NMe.sub.3OTf 2 10138 Pr 2-Cl, 5-NMe.sub.3I 2 10139 Pr 2-F, 4-Cl 2 10140 Pr 2-NO.sub.2, 4-Cl 2 10141 Pr 2-NH.sub.2, 4-Cl 2 10142 Pr 2-NHMe, 4-Cl 2 10143 Pr 2-NMe.sub.2, 4-Cl 2 10144 Pr 2-NMe.sub.3OTf, 4-Cl 2 10145 Pr 2-NMe.sub.3I, 4-Cl 2 10146 Pr 2-F, 5-Cl 2 10147 Pr 2-NO.sub.2, 5-Cl 2 10148 Pr 2-NH.sub.2, 5-Cl 2 10149 Pr 2-NHMe, 5-Cl 2 10150 Pr 2-NMe.sub.2, 5-Cl 2 10151 Pr 2-NMe.sub.3OTf, 5-Cl 2 10152 Pr 2-NMe.sub.3I, 5-Cl 2 10153 Pr 2-Br, 4-F 2 10154 Pr 2-Br, 4-NO.sub.2 2 10155 Pr 2-Br, 4-NH.sub.2 2 10156 Pr 2-Br, 4-NHMe 2 10157 Pr 2-Br, 4-NMe.sub.2 2 10158 Pr 2-Br, 4-NMe.sub.3OTf 2 10159 Pr 2-Br, 4-NMe.sub.3I 2 10160 Pr 2-Br, 5-F 2 10161 Pr 2-Br, 5-NO.sub.2 2 10162 Pr 2-Br, 5-NH.sub.2 2 10163 Pr 2-Br, 5-NHMe 2 10164 Pr 2-Br, 5-NMe.sub.2 2 10165 Pr 2-Br, 5-NMe.sub.3OTf 2 10166 Pr 2-Br, 5-NMe.sub.3I 2 10167 Pr 2-F, 4-Br 2 10168 Pr 2-NO.sub.2, 4-Br 2 10169 Pr 2-NH.sub.2, 4-Br 2 10170 Pr 2-NHMe, 4-Br 2 10171 Pr 2-NMe.sub.2, 4-Br 2 10172 Pr 2-NMe.sub.3OTf, 4-Br 2 10173 Pr 2-NMe.sub.3I, 4-Br 2 10174 Pr 2-I, 4-F 2 10175 Pr 2-I, 4-NO.sub.2 2 10176 Pr 2-I, 4-NH.sub.2 2 10177 Pr 2-I, 4-NHMe 2 10178 Pr 2-I, 4-NMe.sub.2 2 10179 Pr 2-I, 4-NMe.sub.3OTf 2 10180 Pr 2-I, 4-NMe.sub.3I 2 10181 Pr 2-F, 4-I 2 10182 Pr 2-NO.sub.2, 4-I 2 10183 Pr 2-NH.sub.2, 4-I 2 10184 Pr 2-NHMe, 4-I 2 10185 Pr 2-NMe.sub.2, 4-I 2 10186 Pr 2-NMe.sub.3OTf, 4-I 2 10187 Pr 2-NMe.sub.3I, 4-I 2 10188 Pr 2-Me, 3-F 2 10189 Pr 2-Me, 3-NO.sub.2 2 10190 Pr 2-Me, 3-NH.sub.2 2 10191 Pr 2-Me, 3-NHMe 2 10192 Pr 2-Me, 3-NMe.sub.2 2 10193 Pr 2-Me, 3-NMe.sub.3OTf 2 10194 Pr 2-Me, 3-NMe.sub.3I 2 10195 Pr 2-Me, 4-F 2 10196 Pr 2-Me, 4-NO.sub.2 2 10197 Pr 2-Me, 4-NH.sub.2 2 10198 Pr 2-Me, 4-NHMe 2 10199 Pr 2-Me, 4-NMe.sub.2 2 10200 Pr 2-Me, 4-NMe.sub.3OTf 2 10201 Pr 2-Me, 4-NMe.sub.3I 2 10202 Pr 2-Me, 5-F 2 10203 Pr 2-Me, 5-NO.sub.2 2 10204 Pr 2-Me, 5-NH.sub.2 2 10205 Pr 2-Me, 5-NHMe 2 10206 Pr 2-Me, 5-NMe.sub.2 2 10207 Pr 2-Me, 5-NMe.sub.3OTf 2 10208 Pr 2-Me, 5-NMe.sub.3I 2 10209 Pr 2-F, 4-Me 2 10210 Pr 2-NO.sub.2, 4-Me 2 10211 Pr 2-NH.sub.2, 4-Me 2 10212 Pr 2-NHMe, 4-Me 2 10213 Pr 2-NMe.sub.2, 4-Me 2 10214 Pr 2-NMe.sub.3, 4-Me 2 10215 Pr 2-NMe.sub.3OTf, 4-Me 2 10216 Pr 2-NMe.sub.3I, 4-Me 2 10217 Pr 2-SnMe.sub.3, 4-F 2 10218 Pr 2-SnMe.sub.3, 5-F 2 10219 Pr 2-F, 4-SnMe.sub.3 2 10220 Pr 2-Br, 6-Cl, 4-F 2 10221 Pr 2-Br, 6-Cl, 4-NO.sub.2 2 10222 Pr 2-Br, 6-Cl, 4-NH.sub.2 2 10223 Pr 2-Br, 6-Cl, 4- 2 NHMe 10224 Pr 2-Br, 6-Cl, 4-NMe.sub.2 2 10225 Pr 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 10226 Pr 2-Br, 6-Cl, 4- 2 NMe.sub.3I 10227 Pr 2-Me, 6-Cl, 4-F 2 10228 Pr 2-SnMe.sub.3, 6-Cl, 4-F 2 10229 Pr 2-Cl, 4-Me 2 10230 Pr 2-Cl, 4-Br 2 10231 Pr 2-Cl, 4-SnMe.sub.3 2 10232 Pr 2-Br, 4-Cl 2 10233 Pr 2-SnMe.sub.3, 4-Cl 2 10234 Pr 2-Me, 4-Cl 2 10235 Pr 2-Br, 4-Br 2

10236 Pr 2-Br, 4-Me 2 10237 Pr 2-Br, 4-SnMe.sub.3 2 10238 Pr 2-SnMe.sub.3, 4-Br 2 10239 Pr 2-Me, 4-Br 2 10240 Pr 2-Me, 4-SnMe.sub.3 2 10241 Pr 2-SnMe.sub.3, 4-Me 2 10242 Pr 2-Me, 4-Me 2 10243 Pr 2-Et, 4-Br 2 10244 Pr 2-Et, 4-SnMe.sub.3 2 10245 Pr 2-Et, 4-Me 2 10246 Pr 2-Me, 4-Me, 6-Me 2 10247 Pr 2-Me, 4-Br, 6-Me 2 10248 Pr 2-Me, 4-SnMe.sub.3, 6- 2 Me 10249 Pr 2-Et, 6-Me 2 10250 Pr 2-Br, 4-i-Pr 2 10251 Pr 2-SnMe.sub.3, 4-i-Pr 2 10252 Pr 2-Me, 4-i-Pr 2 10253 Pr 2-Br, 4-Br, 6-Br 2 10254 Pr 2-Br, 4-Me, 6-Br 2 10255 Pr 2-Br, 4-SnMe.sub.3, 6- 2 Br 10256 Pr 2-SnMe.sub.3, 4-Br, 6- 2 Br 10257 Pr 2-Br, 4-Br, 6-Me 2 10258 Pr 2-Br, 4-CF.sub.3, 6-Br 2 10259 Pr 2-Br, 4-Br, 6-CF.sub.3 2 10260 Pr 2-CF.sub.3, 4-CF.sub.3 2 10261 Pr 2-Cl, 4-CF.sub.3 2 10262 Pr 2-CF.sub.3, 4-Cl 2 10263 Pr 2-Br, 4-CF.sub.3 2 10264 Pr 2-SnMe.sub.3, 4-CF.sub.3 2 10265 Pr 2-Me, 4-CF.sub.3 2 10266 Pr 2-CF.sub.3, 4-Br 2 10267 Pr 2-CF.sub.3, 4-SnMe.sub.3 2 10268 Pr 2-CF.sub.3, 4-Me 2 10269 Pr 2-Br, 4-OH 2 10270 Pr 2-Br, 4-OMe 2 10271 Pr 2-Br, 4-OMeF 2 10272 Pr 2-Br, 4-OCF.sub.3 2 10273 Pr 2-Br, 4-OEtF 2 10274 Pr 2-Br, 4-OPrF 2 10275 Pr 2-OH, 4-Br 2 10276 Pr 2-OMe, 4-Br 2 10277 Pr 2-OMeF, 4-Br 2 10278 Pr 2-OCF.sub.3, 4-Br 2 10279 Pr 2-OEtF, 4-Br 2 10280 Pr 2-OPrF, 4-Br 2 10281 Pr 2-I, 4-OH 2 10282 Pr 2-I, 4-OMe 2 10283 Pr 2-I, 4-OMeF 2 10284 Pr 2-I, 4-OCF.sub.3 2 10285 Pr 2-I, 4-OEtF 2 10286 Pr 2-I, 4-OPrF 2 10287 Pr 2-OH, 4-I 2 10288 Pr 2-OMe, 4-I 2 10289 Pr 2-OMeF, 4-I 2 10290 Pr 2-OCF.sub.3, 4-I 2 10291 Pr 2-OEtF, 4-I 2 10292 Pr 2-OPrF, 4-I 2 10293 Pr 2-SnMe.sub.3, 4-OH 2 10294 Pr 2-SnMe.sub.3, 4-OMe 2 10295 Pr 2-SnMe.sub.3, 4-OMeF 2 10296 Pr 2-SnMe.sub.3, 4-OCF.sub.3 2 10297 Pr 2-SnMe.sub.3, 4-OEtF 2 10298 Pr 2-SnMe.sub.3, 4-OPrF 2 10299 Pr 2-OH, 4-SnMe.sub.3 2 10300 Pr 2-OMe, 4-SnMe.sub.3 2 10301 Pr 2-OMeF, 4-SnMe.sub.3 2 10302 Pr 2-OCF, 4-SnMe.sub.3 2 10303 Pr 2-OEtF, 4-SnMe.sub.3 2 10304 Pr 2-OPrF, 4-SnMe.sub.3 2 10305 Pr--F H 1 10306 Pr--F 2-t-Bu 1 10307 Pr--F 2-Br 1 10308 Pr--F 3-Br 1 10309 Pr--F 4-Br 1 10310 Pr--F 2-I 1 10311 Pr--F 3-I 1 10312 Pr--F 4-I 1 10313 Pr--F 2-SnMe.sub.3 1 10314 Pr--F 3-SnMe.sub.3 1 10315 Pr--F 4-SnMe.sub.3 1 10316 Pr--F 2-Me 1 10317 Pr--F 3-Me 1 10318 Pr--F 4-Me 1 10319 Pr--F 2-OH 1 10320 Pr--F 3-OH 1 10321 Pr--F 4-OH 1 10322 Pr--F 2-OMe 1 10323 Pr--F 3-OMe 1 10324 Pr--F 4-OMe 1 10325 Pr--F 2-OMeF 1 10326 Pr--F 3-OMeF 1 10327 Pr--F 4-OMeF 1 10328 Pr--F 2-OCF.sub.3 1 10329 Pr--F 3-OCF.sub.3 1 10330 Pr--F 4-OCF.sub.3 1 10331 Pr--F 2-OEtF 1 10332 Pr--F 3-OEtF 1 10333 Pr--F 4-OEtF 1 10334 Pr--F 2-OPrF 1 10335 Pr--F 3-OPrF 1 10336 Pr--F 4-OPrF 1 10337 Pr--F 2-SH 1 10338 Pr--F 3-SH 1 10339 Pr--F 4-SH 1 10340 Pr--F 2-SMe 1 10341 Pr--F 3-SMe 1 10342 Pr--F 4-SMe 1 10343 Pr--F 2-SMeF 1 10344 Pr--F 3-SMeF 1 10345 Pr--F 4-SMeF 1 10346 Pr--F 2-SCF.sub.3 1 10347 Pr--F 3-SCF.sub.3 1 10348 Pr--F 4-SCF.sub.3 1 10349 Pr--F 2-SEtF 1 10350 Pr--F 3-SEtF 1 10351 Pr--F 4-SEtF 1 10352 Pr--F 2-SPrF 1 10353 Pr--F 3-SPrF 1 10354 Pr--F 4-SPrF 1 10355 Pr--F 2-OMe, 4-OMe 1 10356 Pr--F 2-Me, 5-OH 1 10357 Pr--F 2-Me, 5-OMe 1 10358 Pr--F 2-Me, 5-OMeF 1 10359 Pr--F 2-Me, 5-OEtF 1 10360 Pr--F 2-Me, 5-OPrF 1 10361 Pr--F 2-Me, 4-OH 1 10362 Pr--F 2-Me, 4-OMe 1 10363 Pr--F 2-Me, 4-OMeF 1 10364 Pr--F 2-Me, 4-OCF.sub.3 1 10365 Pr--F 2-Me, 4-OEtF 1 10366 Pr--F 2-Me, 4-OPrF 1 10367 Pr--F 2-OH, 4-Me 1 10368 Pr--F 2-OMe, 4-Me 1 10369 Pr--F 2-OMeF, 4-Me 1 10370 Pr--F 2-OCF.sub.3, 4-Me 1 10371 Pr--F 2-OEtF, 4-Me 1 10372 Pr--F 2-OPrF, 4-Me 1 10373 Pr--F 2-Cl, 4-OH 1 10374 Pr--F 2-Cl, 4-OMe 1 10375 Pr--F 2-Cl, 4-OMeF 1 10376 Pr--F 2-Cl, 4-OCF.sub.3 1 10377 Pr--F 2-Cl, 4-OEtF 1 10378 Pr--F 2-Cl, 4-OPrF 1 10379 Pr--F 2-F, 4-F 1 10380 Pr--F 2-Cl, 4-Cl 1 10381 Pr--F 2-Cl, 4-F 1 10382 Pr--F 2-Cl, 4-NO.sub.2 1 10383 Pr--F 2-Cl, 4-NH.sub.2 1 10384 Pr--F 2-Cl, 4-NHMe 1 10385 Pr--F 2-Cl, 4-NMe.sub.2 1 10386 Pr--F 2-Cl, 4-NMe.sub.3OTf 1 10387 Pr--F 2-Cl, 4-NMe.sub.3I 1 10388 Pr--F 2-Cl, 5-F 1 10389 Pr--F 2-Cl, 5-NO.sub.2 1 10390 Pr--F 2-Cl, 5-NH.sub.2 1 10391 Pr--F 2-Cl, 5-NHMe 1 10392 Pr--F 2-Cl, 5-NMe.sub.2 1 10393 Pr--F 2-Cl, 5-NMe.sub.3OTf 1 10394 Pr--F 2-Cl, 5-NMe.sub.3I 1 10395 Pr--F 2-F, 4-Cl 1 10396 Pr--F 2-NO.sub.2, 4-Cl 1 10397 Pr--F 2-NH.sub.2, 4-Cl 1 10398 Pr--F 2-NHMe, 4-Cl 1 10399 Pr--F 2-NMe.sub.2, 4-Cl 1 10400 Pr--F 2-NMe.sub.3OTf, 4-Cl 1 10401 Pr--F 2-NMe.sub.3I, 4-Cl 1 10402 Pr--F 2-F, 5-Cl 1 10403 Pr--F 2-NO.sub.2, 5-Cl 1 10404 Pr--F 2-NH.sub.2, 5-Cl 1 10405 Pr--F 2-NHMe, 5-Cl 1 10406 Pr--F 2-NMe.sub.2, 5-Cl 1 10407 Pr--F 2-NMe.sub.3OTf, 5-Cl 1 10408 Pr--F 2-NMe.sub.3I, 5-Cl 1 10409 Pr--F 2-Br, 4-F 1 10410 Pr--F 2-Br, 4-NO.sub.2 1 10411 Pr--F 2-Br, 4-NH.sub.2 1 10412 Pr--F 2-Br, 4-NHMe 1 10413 Pr--F 2-Br, 4-NMe.sub.2 1 10414 Pr--F 2-Br, 4-NMe.sub.3OTf 1 10415 Pr--F 2-Br, 4-NMe.sub.3I 1 10416 Pr--F 2-Br, 5-F 1 10417 Pr--F 2-Br, 5-NO.sub.2 1 10418 Pr--F 2-Br, 5-NH.sub.2 1 10419 Pr--F 2-Br, 5-NHMe 1 10420 Pr--F 2-Br, 5-NMe.sub.2 1 10421 Pr--F 2-Br, 5-NMe.sub.3OTf 1 10422 Pr--F 2-Br, 5-NMe.sub.3I 1 10423 Pr--F 2-F, 4-Br 1 10424 Pr--F 2-NO.sub.2, 4-Br 1 10425 Pr--F 2-NH.sub.2, 4-Br 1 10426 Pr--F 2-NHMe, 4-Br 1 10427 Pr--F 2-NMe.sub.2, 4-Br 1 10428 Pr--F 2-NMe.sub.3OTf, 4-Br 1 10429 Pr--F 2-NMe.sub.3I, 4-Br 1 10430 Pr--F 2-I, 4-F 1 10431 Pr--F 2-I, 4-NO.sub.2 1 10432 Pr--F 2-I, 4-NH.sub.2 1 10433 Pr--F 2-I, 4-NHMe 1 10434 Pr--F 2-I, 4-NMe.sub.2 1 10435 Pr--F 2-I, 4-NMe.sub.3OTf 1 10436 Pr--F 2-I, 4-NMe.sub.3I 1 10437 Pr--F 2-F, 4-I 1 10438 Pr--F 2-NO.sub.2, 4-I 1 10439 Pr--F 2-NH.sub.2, 4-I 1 10440 Pr--F 2-NHMe, 4-I 1 10441 Pr--F 2-NMe.sub.2, 4-I 1 10442 Pr--F 2-NMe.sub.3OTf, 4-I 1 10443 Pr--F 2-NMe.sub.3I, 4-T 1 10444 Pr--F 2-Me, 3-F 1 10445 Pr--F 2-Me, 3-NO.sub.2 1 10446 Pr--F 2-Me, 3-NH.sub.2 1 10447 Pr--F 2-Me, 3-NHMe 1 10448 Pr--F 2-Me, 3-NMe.sub.2 1 10449 Pr--F 2-Me, 3-NMe.sub.3OTf 1 10450 Pr--F 2-Me, 3-NMe.sub.3I 1 10451 Pr--F 2-Me, 4-F 1 10452 Pr--F 2-Me, 4-NO.sub.2 1 10453 Pr--F 2-Me, 4-NH.sub.2 1 10454 Pr--F 2-Me, 4-NHMe 1 10455 Pr--F 2-Me, 4-NMe.sub.2 1 10456 Pr--F 2-Me, 4-NMe.sub.3OTf 1 10457 Pr--F 2-Me, 4-NMe.sub.3I 1 10458 Pr--F 2-Me, 5-F 1 10459 Pr--F 2-Me, 5-NO.sub.2 1 10460 Pr--F 2-Me, 5-NH.sub.2 1 10461 Pr--F 2-Me, 5-NHMe 1 10462 Pr--F 2-Me, 5-NMe.sub.2 1 10463 Pr--F 2-Me, 5-NMe.sub.3OTf 1 10464 Pr--F 2-Me, 5-NMe.sub.3I 1 10465 Pr--F 2-F, 4-Me 1 10466 Pr--F 2-NO.sub.2, 4-Me 1 10467 Pr--F 2-NH.sub.2, 4-Me 1 10468 Pr--F 2-NHMe, 4-Me 1 10469 Pr--F 2-NMe.sub.2, 4-Me 1 10470 Pr--F 2-NMe.sub.3, 4-Me 1 10471 Pr--F 2-NMe.sub.3OTf, 4-Me 1 10472 Pr--F 2-NMe.sub.3I, 4-Me 1 10473 Pr--F 2-SnMe.sub.3, 4-F 1 10474 Pr--F 2-SnMe.sub.3, 5-F 1 10475 Pr--F 2-F, 4-SnMe.sub.3 1 10476 Pr--F 2-Br, 6-Cl, 4-F 1 10477 Pr--F 2-Br, 6-Cl, 4-NO.sub.2 1 10478 Pr--F 2-Br, 6-Cl, 4-NH.sub.2 1 10479 Pr--F 2-Br, 6-Cl, 4- 1 NHMe 10480 Pr--F 2-Br, 6-Cl, 4-NMe.sub.2 1 10481 Pr--F 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf

10482 Pr--F 2-Br, 6-Cl, 4- 1 NMe.sub.3I 10483 Pr--F 2-Me, 6-Cl, 4-F 1 10484 Pr--F 2-SnMe.sub.3, 6-Cl, 4-F 1 10485 Pr--F 2-Cl, 4-Me 1 10486 Pr--F 2-Cl, 4-Br 1 10487 Pr--F 2-Cl, 4-SnMe.sub.3 1 10488 Pr--F 2-Br, 4-Cl 1 10489 Pr--F 2-SnMe.sub.3, 4-Cl 1 10490 Pr--F 2-Me, 4-Cl 1 10491 Pr--F 2-Br, 4-Br 1 10492 Pr--F 2-Br, 4-Me 1 10493 Pr--F 2-Br, 4-SnMe.sub.3 1 10494 Pr--F 2-SnMe.sub.3, 4-Br 1 10495 Pr--F 2-Me, 4-Br 1 10496 Pr--F 2-Me, 4-SnMe.sub.3 1 10497 Pr--F 2-SnMe.sub.3, 4-Me 1 10498 Pr--F 2-Me, 4-Me 1 10499 Pr--F 2-Et, 4-Br 1 10500 Pr--F 2-Et, 4-SnMe.sub.3 1 10501 Pr--F 2-Et, 4-Me 1 10502 Pr--F 2-Me, 4-Me, 6-Me 1 10503 Pr--F 2-Me, 4-Br, 6-Me 1 10504 Pr--F 2-Me, 4-SnMe.sub.3, 6- 1 Me 10505 Pr--F 2-Et, 6-Me 1 10506 Pr--F 2-Br, 4-i-Pr 1 10507 Pr--F 2-SnMe.sub.3, 4-i-Pr 1 10508 Pr--F 2-Me, 4-i-Pr 1 10509 Pr--F 2-Br, 4-Br, 6-Br 1 10510 Pr--F 2-Br, 4-Me, 6-Br 1 10511 Pr--F 2-Br, 4-SnMe.sub.3, 6- 1 Br 10512 Pr--F 2-SnMe.sub.3, 4-Br, 6- 1 Br 10513 Pr--F 2-Br, 4-Br, 6-Me 1 10514 Pr--F 2-Br, 4-CF.sub.3, 6-Br 1 10515 Pr--F 2-Br, 4-Br, 6-CF.sub.3 1 10516 Pr--F 2-CF.sub.3, 4-CF.sub.3 1 10517 Pr--F 2-Cl, 4-CF.sub.3 1 10518 Pr--F 2-CF.sub.3, 4-Cl 1 10519 Pr--F 2-Br, 4-CF.sub.3 1 10520 Pr--F 2-SnMe.sub.3, 4-CF.sub.3 1 10521 Pr--F 2-Me, 4-CF.sub.3 1 10522 Pr--F 2-CF.sub.3, 4-Br 1 10523 Pr--F 2-CF.sub.3, 4-SnMe.sub.3 1 10524 Pr--F 2-CF.sub.3, 4-Me 1 10525 Pr--F 2-Br, 4-OH 1 10526 Pr--F 2-Br, 4-OMe 1 10527 Pr--F 2-Br, 4-OMeF 1 10528 Pr--F 2-Br, 4-OCF.sub.3 1 10529 Pr--F 2-Br, 4-OEtF 1 10530 Pr--F 2-Br, 4-OPrF 1 10531 Pr--F 2-OH, 4-Br 1 10532 Pr--F 2-OMe, 4-Br 1 10533 Pr--F 2-OMeF, 4-Br 1 10534 Pr--F 2-OCF.sub.3, 4-Br 1 10535 Pr--F 2-OEtF, 4-Br 1 10536 Pr--F 2-OPrF, 4-Br 1 10537 Pr--F 2-I, 4-OH 1 10538 Pr--F 2-I, 4-OMe 1 10539 Pr--F 2-I, 4-OMeF 1 10540 Pr--F 2-I, 4-OCF.sub.3 1 10541 Pr--F 2-I, 4-OEtF 1 10542 Pr--F 2-I, 4-OPrF 1 10543 Pr--F 2-OH, 4-I 1 10544 Pr--F 2-OMe, 4-I 1 10545 Pr--F 2-OMeF, 4-I 1 10546 Pr--F 2-OCF.sub.3, 4-I 1 10547 Pr--F 2-OEtF, 4-I 1 10548 Pr--F 2-OPrF, 4-I 1 10549 Pr--F 2-SnMe.sub.3, 4-OH 1 10550 Pr--F 2-SnMe.sub.3, 4-OMe 1 10551 Pr--F 2-SnMe.sub.3, 4-OMeF 1 10552 Pr--F 2-SnMe.sub.3, 4-OCF.sub.3 1 10553 Pr--F 2-SnMe.sub.3, 4-OEtF 1 10554 Pr--F 2-SnMe.sub.3, 4-OPrF 1 10555 Pr--F 2-OH, 4-SnMe.sub.3 1 10556 Pr--F 2-OMe, 4-SnMe.sub.3 1 10557 Pr--F 2-OMeF, 4-SnMe.sub.3 1 10558 Pr--F 2-OCF.sub.3, 4-SnMe.sub.3 1 10559 Pr--F 2-OEtF, 4-SnMe.sub.3 1 10560 Pr--F 2-OPrF, 4-SnMe.sub.3 1 10561 Pr--F H 2 10562 Pr--F 2-t-Bu 2 10563 Pr--F 2-Br 2 10564 Pr--F 3-Br 2 10565 Pr--F 4-Br 2 10566 Pr--F 2-I 2 10567 Pr--F 3-I 2 10568 Pr--F 4-I 2 10569 Pr--F 2-SnMe.sub.3 2 10570 Pr--F 3-SnMe.sub.3 2 10571 Pr--F 4-SnMe.sub.3 2 10572 Pr--F 2-Me 2 10573 Pr--F 3-Me 2 10574 Pr--F 4-Me 2 10575 Pr--F 2-OH 2 10576 Pr--F 3-OH 2 10577 Pr--F 4-OH 2 10578 Pr--F 2-OMe 2 10579 Pr--F 3-OMe 2 10580 Pr--F 4-OMe 2 10581 Pr--F 2-OMeF 2 10582 Pr--F 3-OMeF 2 10583 Pr--F 4-OMeF 2 10584 Pr--F 2-OCF.sub.3 2 10585 Pr--F 3-OCF.sub.3 2 10586 Pr--F 4-OCF.sub.3 2 10587 Pr--F 2-OEtF 2 10588 Pr--F 3-OEtF 2 10589 Pr--F 4-OEtF 2 10590 Pr--F 2-OPrF 2 10591 Pr--F 3-OPrF 2 10592 Pr--F 4-OPrF 2 10593 Pr--F 2-SH 2 10594 Pr--F 3-SH 2 10595 Pr--F 4-SH 2 10596 Pr--F 2-SMe 2 10597 Pr--F 3-SMe 2 10598 Pr--F 4-SMe 2 10599 Pr--F 2-SMeF 2 10600 Pr--F 3-SMeF 2 10601 Pr--F 4-SMeF 2 10602 Pr--F 2-SCF.sub.3 2 10603 Pr--F 3-SCF.sub.3 2 10604 Pr--F 4-SCF.sub.3 2 10605 Pr--F 2-SEtF 2 10606 Pr--F 3-SEtF 2 10607 Pr--F 4-SEtF 2 10608 Pr--F 2-SPrF 2 10609 Pr--F 3-SPrF 2 10610 Pr--F 4-SPrF 2 10611 Pr--F 2-OMe, 4-OMe 2 10612 Pr--F 2-Me, 5-OH 2 10613 Pr--F 2-Me, 5-OMe 2 10614 Pr--F 2-Me, 5-OMeF 2 10615 Pr--F 2-Me, 5-OEtF 2 10616 Pr--F 2-Me, 5-OPrF 2 10617 Pr--F 2-Me, 4-OH 2 10618 Pr--F 2-Me, 4-OMe 2 10619 Pr--F 2-Me, 4-OMeF 2 10620 Pr--F 2-Me, 4-OCF.sub.3 2 10621 Pr--F 2-Me, 4-OEtF 2 10622 Pr--F 2-Me, 4-OPrF 2 10623 Pr--F 2-OH, 4-Me 2 10624 Pr--F 2-OMe, 4-Me 2 10625 Pr--F 2-OMeF, 4-Me 2 10626 Pr--F 2-OCF.sub.3, 4-Me 2 10627 Pr--F 2-OEtF, 4-Me 2 10628 Pr--F 2-OPrF, 4-Me 2 10629 Pr--F 2-Cl, 4-OH 2 10630 Pr--F 2-Cl, 4-OMe 2 10631 Pr--F 2-Cl, 4-OMeF 2 10632 Pr--F 2-Cl, 4-OCF.sub.3 2 10633 Pr--F 2-Cl, 4-OEtF 2 10634 Pr--F 2-Cl, 4-OPrF 2 10635 Pr--F 2-F, 4-F 2 10636 Pr--F 2-Cl, 4-Cl 2 10637 Pr--F 2-Cl, 4-F 2 10638 Pr--F 2-Cl, 4-NO.sub.2 2 10639 Pr--F 2-Cl, 4-NH.sub.2 2 10640 Pr--F 2-Cl, 4-NHMe 2 10641 Pr--F 2-Cl, 4-NMe.sub.2 2 10642 Pr--F 2-Cl, 4-NMe.sub.3OTf 2 10643 Pr--F 2-Cl, 4-NMe.sub.3I 2 10644 Pr--F 2-Cl, 5-F 2 10645 Pr--F 2-Cl, 5-NO.sub.2 2 10646 Pr--F 2-Cl, 5-NH.sub.2 2 10647 Pr--F 2-Cl, 5-NHMe 2 10648 Pr--F 2-Cl, 5-NMe.sub.2 2 10649 Pr--F 2-Cl, 5-NMe.sub.3OTf 2 10650 Pr--F 2-Cl, 5-NMe.sub.3I 2 10651 Pr--F 2-F, 4-Cl 2 10652 Pr--F 2-NO.sub.2, 4-Cl 2 10653 Pr--F 2-NH.sub.2, 4-Cl 2 10654 Pr--F 2-NHMe, 4-Cl 2 10655 Pr--F 2-NMe.sub.2, 4-Cl 2 10656 Pr--F 2-NMe.sub.3OTf, 4-Cl 2 10657 Pr--F 2-NMe.sub.3I, 4-Cl 2 10658 Pr--F 2-F, 5-Cl 2 10659 Pr--F 2-NO.sub.2, 5-Cl 2 10660 Pr--F 2-NH.sub.2, 5-Cl 2 10661 Pr--F 2-NHMe, 5-Cl 2 10662 Pr--F 2-NMe.sub.2, 5-Cl 2 10663 Pr--F 2-NMe.sub.3OTf, 5-Cl 2 10664 Pr--F 2-NMe.sub.3I, 5-Cl 2 10665 Pr--F 2-Br, 4-F 2 10666 Pr--F 2-Br, 4-NO.sub.2 2 10667 Pr--F 2-Br, 4-NH.sub.2 2 10668 Pr--F 2-Br, 4-NHMe 2 10669 Pr--F 2-Br, 4-NMe.sub.2 2 10670 Pr--F 2-Br, 4-NMe.sub.3OTf 2 10671 Pr--F 2-Br, 4-NMe.sub.3I 2 10672 Pr--F 2-Br, 5-F 2 10673 Pr--F 2-Br, 5-NO.sub.2 2 10674 Pr--F 2-Br, 5-NH.sub.2 2 10675 Pr--F 2-Br, 5-NHMe 2 10676 Pr--F 2-Br, 5-NMe.sub.2 2 10677 Pr--F 2-Br, 5-NMe.sub.3OTf 2 10678 Pr--F 2-Br, 5-NMe.sub.3I 2 10679 Pr--F 2-F, 4-Br 2 10680 Pr--F 2-NO.sub.2, 4-Br 2 10681 Pr--F 2-NH.sub.2, 4-Br 2 10682 Pr--F 2-NHMe, 4-Br 2 10683 Pr--F 2-NMe.sub.2, 4-Br 2 10684 Pr--F 2-NMe.sub.3OTf, 4-Br 2 10685 Pr--F 2-NMe.sub.3I, 4-Br 2 10686 Pr--F 2-I, 4-F 2 10687 Pr--F 2-I, 4-NO.sub.2 2 10688 Pr--F 2-I, 4-NH.sub.2 2 10689 Pr--F 2-I, 4-NHMe 2 10690 Pr--F 2-I, 4-NMe.sub.2 2 10691 Pr--F 2-I, 4-NMe.sub.3OTf 2 10692 Pr--F 2-I, 4-NMe.sub.3I 2 10693 Pr--F 2-F, 4-I 2 10694 Pr--F 2-NO.sub.2, 4-I 2 10695 Pr--F 2-NH.sub.2, 4-I 2 10696 Pr--F 2-NHMe, 4-I 2 10697 Pr--F 2-NMe.sub.2, 4-I 2 10698 Pr--F 2-NMe.sub.3OTf, 4-I 2 10699 Pr--F 2-NMe.sub.3I, 4-I 2 10700 Pr--F 2-Me, 3-F 2 10701 Pr--F 2-Me, 3-NO.sub.2 2 10702 Pr--F 2-Me, 3-NH.sub.2 2 10703 Pr--F 2-Me, 3-NHMe 2 10704 Pr--F 2-Me, 3-NMe.sub.2 2 10705 Pr--F 2-Me, 3-NMe.sub.3OTf 2 10706 Pr--F 2-Me, 3-NMe.sub.3I 2 10707 Pr--F 2-Me, 4-F 2 10708 Pr--F 2-Me, 4-NO.sub.2 2 10709 Pr--F 2-Me, 4-NH.sub.2 2 10710 Pr--F 2-Me, 4-NHMe 2 10711 Pr--F 2-Me, 4-NMe.sub.2 2 10712 Pr--F 2-Me, 4-NMe.sub.3OTf 2 10713 Pr--F 2-Me, 4-NMe.sub.3I 2 10714 Pr--F 2-Me, 5-F 2 10715 Pr--F 2-Me, 5-NO.sub.2 2 10716 Pr--F 2-Me, 5-NH.sub.2 2 10717 Pr--F 2-Me, 5-NHMe 2 10718 Pr--F 2-Me, 5-NMe.sub.2 2 10719 Pr--F 2-Me, 5-NMe.sub.3OTf 2 10720 Pr--F 2-Me, 5-NMe.sub.3I 2 10721 Pr--F 2-F, 4-Me 2 10722 Pr--F 2-NO.sub.2, 4-Me 2 10723 Pr--F 2-NH.sub.2, 4-Me 2 10724 Pr--F 2-NHMe, 4-Me 2 10725 Pr--F 2-NMe.sub.2, 4-Me 2 10726 Pr--F 2-NMe.sub.3, 4-Me 2 10727 Pr--F 2-NMe.sub.3OTf, 4-Me 2 10728 Pr--F 2-NMe.sub.3I, 4-Me 2

10729 Pr--F 2-SnMe.sub.3, 4-F 2 10730 Pr--F 2-SnMe.sub.3, 5-F 2 10731 Pr--F 2-F, 4-SnMe.sub.3 2 10732 Pr--F 2-Br, 6-Cl, 4-F 2 10733 Pr--F 2-Br, 6-Cl, 4-NO.sub.2 2 10734 Pr--F 2-Br, 6-Cl, 4-NH.sub.2 2 10735 Pr--F 2-Br, 6-Cl, 4- 2 NHMe 10736 Pr--F 2-Br, 6-Cl, 4-NMe.sub.2 2 10737 Pr--F 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 10738 Pr--F 2-Br, 6-Cl, 4- 2 NMe.sub.3I 10739 Pr--F 2-Me, 6-Cl, 4-F 2 10740 Pr--F 2-SnMe.sub.3, 6-Cl, 4-F 2 10741 Pr--F 2-Cl, 4-Me 2 10742 Pr--F 2-Cl, 4-Br 2 10743 Pr--F 2-Cl, 4-SnMe.sub.3 2 10744 Pr--F 2-Br, 4-Cl 2 10745 Pr--F 2-SnMe.sub.3, 4-Cl 2 10746 Pr--F 2-Me, 4-Cl 2 10747 Pr--F 2-Br, 4-Br 2 10748 Pr--F 2-Br, 4-Me 2 10749 Pr--F 2-Br, 4-SnMe.sub.3 2 10750 Pr--F 2-SnMe.sub.3, 4-Br 2 10751 Pr--F 2-Me, 4-Br 2 10752 Pr--F 2-Me, 4-SnMe.sub.3 2 10753 Pr--F 2-SnMe.sub.3, 4-Me 2 10754 Pr--F 2-Me, 4-Me 2 10755 Pr--F 2-Et, 4-Br 2 10756 Pr--F 2-Et, 4-SnMe.sub.3 2 10757 Pr--F 2-Et, 4-Me 2 10758 Pr--F 2-Me, 4-Me, 6-Me 2 10759 Pr--F 2-Me, 4-Br, 6-Me 2 10760 Pr--F 2-Me, 4-SnMe.sub.3, 6- 2 Me 10761 Pr--F 2-Et, 6-Me 2 10762 Pr--F 2-Br, 4-i-Pr 2 10763 Pr--F 2-SnMe.sub.3, 4-i-Pr 2 10764 Pr--F 2-Me, 4-i-Pr 2 10765 Pr--F 2-Br, 4-Br, 6-Br 2 10766 Pr--F 2-Br, 4-Me, 6-Br 2 10767 Pr--F 2-Br, 4-SnMe.sub.3, 6- 2 Br 10768 Pr--F 2-SnMe.sub.3, 4-Br, 6- 2 Br 10769 Pr--F 2-Br, 4-Br, 6-Me 2 10770 Pr--F 2-Br, 4-CF.sub.3, 6-Br 2 10771 Pr--F 2-Br, 4-Br, 6-CF.sub.3 2 10772 Pr--F 2-CF.sub.3, 4-CF.sub.3 2 10773 Pr--F 2-Cl, 4-CF.sub.3 2 10774 Pr--F 2-CF.sub.3, 4-Cl 2 10775 Pr--F 2-Br, 4-CF.sub.3 2 10776 Pr--F 2-SnMe.sub.3, 4-CF.sub.3 2 10777 Pr--F 2-Me, 4-CF.sub.3 2 10778 Pr--F 2-CF.sub.3, 4-Br 2 10779 Pr--F 2-CF.sub.3, 4-SnMe.sub.3 2 10780 Pr--F 2-CF.sub.3, 4-Me 2 10781 Pr--F 2-Br, 4-OH 2 10782 Pr--F 2-Br, 4-OMe 2 10783 Pr--F 2-Br, 4-OMeF 2 10784 Pr--F 2-Br, 4-OCF.sub.3 2 10785 Pr--F 2-Br, 4-OEtF 2 10786 Pr--F 2-Br, 4-OPrF 2 10787 Pr--F 2-OH, 4-Br 2 10788 Pr--F 2-OMe, 4-Br 2 10789 Pr--F 2-OMeF, 4-Br 2 10790 Pr--F 2-OCF.sub.3, 4-Br 2 10791 Pr--F 2-OEtF, 4-Br 2 10792 Pr--F 2-OPrF, 4-Br 2 10793 Pr--F 2-I, 4-OH 2 10794 Pr--F 2-I, 4-OMe 2 10795 Pr--F 2-I, 4-OMeF 2 10796 Pr--F 2-I, 4-OCF.sub.3 2 10797 Pr--F 2-I, 4-OEtF 2 10798 Pr--F 2-I, 4-OPrF 2 10799 Pr--F 2-OH, 4-I 2 10800 Pr--F 2-OMe, 4-I 2 10801 Pr--F 2-OMeF, 4-I 2 10802 Pr--F 2-OCF.sub.3, 4-I 2 10803 Pr--F 2-OEtF, 4-I 2 10804 Pr--F 2-OPrF, 4-I 2 10805 Pr--F 2-SnMe.sub.3, 4-OH 2 10806 Pr--F 2-SnMe.sub.3, 4-OMe 2 10807 Pr--F 2-SnMe.sub.3, 4-OMeF 2 10808 Pr--F 2-SnMe.sub.3, 4-OCF.sub.3 2 10809 Pr--F 2-SnMe.sub.3, 4-OEtF 2 10810 Pr--F 2-SnMe.sub.3, 4-OPrF 2 10811 Pr--F 2-OH, 4-SnMe.sub.3 2 10812 Pr--F 2-OMe, 4-SnMe.sub.3 2 10813 Pr--F 2-OMeF, 4-SnMe.sub.3 2 10814 Pr--F 2-OCF.sub.3, 4-SnMe.sub.3 2 10815 Pr--F 2-OEtF, 4-SnMe.sub.3 2 10816 Pr--F 2-OPrF, 4-SnMe.sub.3 2 10817 Et H 1 10818 Et 2-t-Bu 1 10819 Et 2-Br 1 10820 Et 3-Br 1 10821 Et 4-Br 1 10822 Et 2-I 1 10823 Et 3-I 1 10824 Et 4-I 1 10825 Et 2-SnMe.sub.3 1 10826 Et 3-SnMe.sub.3 1 10827 Et 4-SnMe.sub.3 1 10828 Et 2-Me 1 10829 Et 3-Me 1 10830 Et 4-Me 1 10831 Et 2-OH 1 10832 Et 3-OH 1 10833 Et 4-OH 1 10834 Et 2-OMe 1 10835 Et 3-OMe 1 10836 Et 4-OMe 1 10837 Et 2-OMeF 1 10838 Et 3-OMeF 1 10839 Et 4-OMeF 1 10840 Et 2-OCF.sub.3 1 10841 Et 3-OCF.sub.3 1 10842 Et 4-OCF.sub.3 1 10843 Et 2-OEtF 1 10844 Et 3-OEtF 1 10845 Et 4-OEtF 1 10846 Et 2-OPrF 1 10847 Et 3-OPrF 1 10848 Et 4-OPrF 1 10849 Et 2-SH 1 10850 Et 3-SH 1 10851 Et 4-SH 1 10852 Et 2-SMe 1 10853 Et 3-SMe 1 10854 Et 4-SMe 1 10855 Et 2-SMeF 1 10856 Et 3-SMeF 1 10857 Et 4-SMeF 1 10858 Et 2-SCF.sub.3 1 10859 Et 3-SCF.sub.3 1 10860 Et 4-SCF.sub.3 1 10861 Et 2-SEtF 1 10862 Et 3-SEtF 1 10863 Et 4-SEtF 1 10864 Et 2-SPrF 1 10865 Et 3-SPrF 1 10866 Et 4-SPrF 1 10867 Et 2-OMe, 4-OMe 1 10868 Et 2-Me, 5-OH 1 10869 Et 2-Me, 5-OMe 1 10870 Et 2-Me, 5-OMeF 1 10871 Et 2-Me, 5-OEtF 1 10872 Et 2-Me, 5-OPrF 1 10873 Et 2-Me, 4-OH 1 10874 Et 2-Me, 4-OMe 1 10875 Et 2-Me, 4-OMeF 1 10876 Et 2-Me, 4-OCF.sub.3 1 10877 Et 2-Me, 4-OEtF 1 10878 Et 2-Me, 4-OPrF 1 10879 Et 2-OH, 4-Me 1 10880 Et 2-OMe, 4-Me 1 10881 Et 2-OMeF, 4-Me 1 10882 Et 2-OCF.sub.3, 4-Me 1 10883 Et 2-OEtF, 4-Me 1 10884 Et 2-OPrF, 4-Me 1 10885 Et 2-Cl, 4-OH 1 10886 Et 2-Cl, 4-OMe 1 10887 Et 2-Cl, 4-OMeF 1 10888 Et 2-Cl, 4-OCF.sub.3 1 10889 Et 2-Cl, 4-OEtF 1 10890 Et 2-Cl, 4-OPrF 1 10891 Et 2-F, 4-F 1 10892 Et 2-Cl, 4-Cl 1 10893 Et 2-Cl, 4-F 1 10894 Et 2-Cl, 4-NO.sub.2 1 10895 Et 2-Cl, 4-NH.sub.2 1 10896 Et 2-Cl, 4-NHMe 1 10897 Et 2-Cl, 4-NMe.sub.2 1 10898 Et 2-Cl, 4-NMe.sub.3OTf 1 10899 Et 2-Cl, 4-NMe.sub.3I 1 10900 Et 2-Cl, 5-F 1 10901 Et 2-Cl, 5-NO.sub.2 1 10902 Et 2-Cl, 5-NH.sub.2 1 10903 Et 2-Cl, 5-NHMe 1 10904 Et 2-Cl, 5-NMe.sub.2 1 10905 Et 2-Cl, 5-NMe.sub.3OTf 1 10906 Et 2-Cl, 5-NMe.sub.3I 1 10907 Et 2-F, 4-Cl 1 10908 Et 2-NO.sub.2, 4-Cl 1 10909 Et 2-NH.sub.2, 4-Cl 1 10910 Et 2-NHMe, 4-Cl 1 10911 Et 2-NMe.sub.2, 4-Cl 1 10912 Et 2-NMe.sub.3OTf, 4-Cl 1 10913 Et 2-NMe.sub.3I, 4-Cl 1 10914 Et 2-F, 5-Cl 1 10915 Et 2-NO.sub.2, 5-Cl 1 10916 Et 2-NH.sub.2, 5-Cl 1 10917 Et 2-NHMe, 5-Cl 1 10918 Et 2-NMe.sub.2, 5-Cl 1 10919 Et 2-NMe.sub.3OTf, 5-Cl 1 10920 Et 2-NMe.sub.3I, 5-Cl 1 10921 Et 2-Br, 4-F 1 10922 Et 2-Br, 4-NO.sub.2 1 10923 Et 2-Br, 4-NH.sub.2 1 10924 Et 2-Br, 4-NHMe 1 10925 Et 2-Br, 4-NMe.sub.2 1 10926 Et 2-Br, 4-NMe.sub.3OTf 1 10927 Et 2-Br, 4-NMe.sub.3I 1 10928 Et 2-Br, 5-F 1 10929 Et 2-Br, 5-NO.sub.2 1 10930 Et 2-Br, 5-NH.sub.2 1 10931 Et 2-Br, 5-NHMe 1 10932 Et 2-Br, 5-NMe.sub.2 1 10933 Et 2-Br, 5-NMe.sub.3OTf 1 10934 Et 2-Br, 5-NMe.sub.3I 1 10935 Et 2-F, 4-Br 1 10936 Et 2-NO.sub.2, 4-Br 1 10937 Et 2-NH.sub.2, 4-Br 1 10938 Et 2-NHMe, 4-Br 1 10939 Et 2-NMe.sub.2, 4-Br 1 10940 Et 2-NMe.sub.3OTf, 4-Br 1 10941 Et 2-NMe.sub.3I, 4-Br 1 10942 Et 2-I, 4-F 1 10943 Et 2-I, 4-NO.sub.2 1 10944 Et 2-I, 4-NH.sub.2 1 10945 Et 2-I, 4-NHMe 1 10946 Et 2-I, 4-NMe.sub.2 1 10947 Et 2-I, 4-NMe.sub.3OTf 1 10948 Et 2-I, 4-NMe.sub.3I 1 10949 Et 2-F, 4-I 1 10950 Et 2-NO.sub.2, 4-I 1 10951 Et 2-NH.sub.2, 4-I 1 10952 Et 2-NHMe, 4-I 1 10953 Et 2-NMe.sub.2, 4-I 1 10954 Et 2-NMe.sub.3OTf, 4-I 1 10955 Et 2-NMe.sub.3I, 4-I 1 10956 Et 2-Me, 3-F 1 10957 Et 2-Me, 3-NO.sub.2 1 10958 Et 2-Me, 3-NH.sub.2 1 10959 Et 2-Me, 3-NHMe 1 10960 Et 2-Me, 3-NMe.sub.2 1 10961 Et 2-Me, 3-NMe.sub.3OTf 1 10962 Et 2-Me, 3-NMe.sub.3I 1 10963 Et 2-Me, 4-F 1 10964 Et 2-Me, 4-NO.sub.2 1 10965 Et 2-Me, 4-NH.sub.2 1 10966 Et 2-Me, 4-NHMe 1 10967 Et 2-Me, 4-NMe.sub.2 1 10968 Et 2-Me, 4-NMe.sub.3OTf 1 10969 Et 2-Me, 4-NMe.sub.3I 1 10970 Et 2-Me, 5-F 1 10971 Et 2-Me, 5-NO.sub.2 1 10972 Et 2-Me, 5-NH.sub.2 1 10973 Et 2-Me, 5-NHMe 1

10974 Et 2-Me, 5-NMe.sub.2 1 10975 Et 2-Me, 5-NMe.sub.3OTf 1 10976 Et 2-Me, 5-NMe.sub.3I 1 10977 Et 2-F, 4-Me 1 10978 Et 2-NO.sub.2, 4-Me 1 10979 Et 2-NH.sub.2, 4-Me 1 10980 Et 2-NHMe, 4-Me 1 10981 Et 2-NMe.sub.2, 4-Me 1 10982 Et 2-NMe.sub.3, 4-Me 1 10983 Et 2-NMe.sub.3OTf, 4-Me 1 10984 Et 2-NMe.sub.3I, 4-Me 1 10985 Et 2-SnMe.sub.3, 4-F 1 10986 Et 2-SnMe.sub.3, 5-F 1 10987 Et 2-F, 4-SnMe.sub.3 1 10988 Et 2-Br, 6-Cl, 4-F 1 10989 Et 2-Br, 6-Cl, 4-NO.sub.2 1 10990 Et 2-Br, 6-Cl, 4-NH.sub.2 1 10991 Et 2-Br, 6-Cl, 4- 1 NHMe 10992 Et 2-Br, 6-Cl, 4-NMe.sub.2 1 10993 Et 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 10994 Et 2-Br, 6-Cl, 4- 1 NMe.sub.3I 10995 Et 2-Me, 6-Cl, 4-F 1 10996 Et 2-SnMe.sub.3, 6-Cl, 4-F 1 10997 Et 2-Cl, 4-Me 1 10998 Et 2-Cl, 4-Br 1 10999 Et 2-Cl, 4-SnMe.sub.3 1 11000 Et 2-Br, 4-Cl 1 11001 Et 2-SnMe.sub.3, 4-Cl 1 11002 Et 2-Me, 4-Cl 1 11003 Et 2-Br, 4-Br 1 11004 Et 2-Br, 4-Me 1 11005 Et 2-Br, 4-SnMe.sub.3 1 11006 Et 2-SnMe.sub.3, 4-Br 1 11007 Et 2-Me, 4-Br 1 11008 Et 2-Me, 4-SnMe.sub.3 1 11009 Et 2-SnMe.sub.3, 4-Me 1 11010 Et 2-Me, 4-Me 1 11011 Et 2-Et, 4-Br 1 11012 Et 2-Et, 4-SnMe.sub.3 1 11013 Et 2-Et, 4-Me 1 11014 Et 2-Me, 4-Me, 6-Me 1 11015 Et 2-Me, 4-Br, 6-Me 1 11016 Et 2-Me, 4-SnMe.sub.3, 6- 1 Me 11017 Et 2-Et, 6-Me 1 11018 Et 2-Br, 4-i-Pr 1 11019 Et 2-SnMe.sub.3, 4-i-Pr 1 11020 Et 2-Me, 4-i-Pr 1 11021 Et 2-Br, 4-Br, 6-Br 1 11022 Et 2-Br, 4-Me, 6-Br 1 11023 Et 2-Br, 4-SnMe.sub.3, 6- 1 Br 11024 Et 2-SnMe.sub.3, 4-Br, 6- 1 Br 11025 Et 2-Br, 4-Br, 6-Me 1 11026 Et 2-Br, 4-CF.sub.3, 6-Br 1 11027 Et 2-Br, 4-Br, 6-CF.sub.3 1 11028 Et 2-CF.sub.3, 4-CF.sub.3 1 11029 Et 2-Cl, 4-CF.sub.3 1 11030 Et 2-CF.sub.3, 4-Cl 1 11031 Et 2-Br, 4-CF.sub.3 1 11032 Et 2-SnMe.sub.3, 4-CF.sub.3 1 11033 Et 2-Me, 4-CF.sub.3 1 11034 Et 2-CF.sub.3, 4-Br 1 11035 Et 2-CF.sub.3, 4-SnMe.sub.3 1 11036 Et 2-CF.sub.3, 4-Me 1 11037 Et 2-Br, 4-OH 1 11038 Et 2-Br, 4-OMe 1 11039 Et 2-Br, 4-OMeF 1 11040 Et 2-Br, 4-OCF.sub.3 1 11041 Et 2-Br, 4-OEtF 1 11042 Et 2-Br, 4-OPrF 1 11043 Et 2-OH, 4-Br 1 11044 Et 2-OMe, 4-Br 1 11045 Et 2-OMeF, 4-Br 1 11046 Et 2-OCF.sub.3, 4-Br 1 11047 Et 2-OEtF, 4-Br 1 11048 Et 2-OPrF, 4-Br 1 11049 Et 2-I, 4-OH 1 11050 Et 2-I, 4-OMe 1 11051 Et 2-I, 4-OMeF 1 11052 Et 2-I, 4-OCF.sub.3 1 11053 Et 2-I, 4-OEtF 1 11054 Et 2-I, 4-OPrF 1 11055 Et 2-OH, 4-I 1 11056 Et 2-OMe, 4-I 1 11057 Et 2-OMeF, 4-I 1 11058 Et 2-OCF.sub.3, 4-I 1 11059 Et 2-OEtF, 4-I 1 11060 Et 2-OPrF, 4-I 1 11061 Et 2-SnMe.sub.3, 4-OH 1 11062 Et 2-SnMe.sub.3, 4-OMe 1 11063 Et 2-SnMe.sub.3, 4-OMeF 1 11064 Et 2-SnMe.sub.3, 4-OCF.sub.3 1 11065 Et 2-SnMe.sub.3, 4-OEtF 1 11066 Et 2-SnMe.sub.3, 4-OPrF 1 11067 Et 2-OH, 4-SnMe.sub.3 1 11068 Et 2-OMe, 4-SnMe.sub.3 1 11069 Et 2-OMeF, 4-SnMe.sub.3 1 11070 Et 2-OCF.sub.3, 4-SnMe.sub.3 1 11071 Et 2-OEtF, 4-SnMe.sub.3 1 11072 Et 2-OPrF, 4-SnMe.sub.3 1 11073 Et H 2 11074 Et 2-t-Bu 2 11075 Et 2-Br 2 11076 Et 3-Br 2 11077 Et 4-Br 2 11078 Et 2-I 2 11079 Et 3-I 2 11080 Et 4-I 2 11081 Et 2-SnMe.sub.3 2 11082 Et 3-SnMe.sub.3 2 11083 Et 4-SnMe.sub.3 2 11084 Et 2-Me 2 11085 Et 3-Me 2 11086 Et 4-Me 2 11087 Et 2-OH 2 11088 Et 3-OH 2 11089 Et 4-OH 2 11090 Et 2-OMe 2 11091 Et 3-OMe 2 11092 Et 4-OMe 2 11093 Et 2-OMeF 2 11094 Et 3-OMeF 2 11095 Et 4-OMeF 2 11096 Et 2-OCF.sub.3 2 11097 Et 3-OCF.sub.3 2 11098 Et 4-OCF.sub.3 2 11099 Et 2-OEtF 2 11100 Et 3-OEtF 2 11101 Et 4-OEtF 2 11102 Et 2-OPrF 2 11103 Et 3-OPrF 2 11104 Et 4-OPrF 2 11105 Et 2-SH 2 11106 Et 3-SH 2 11107 Et 4-SH 2 11108 Et 2-SMe 2 11109 Et 3-SMe 2 11110 Et 4-SMe 2 11111 Et 2-SMeF 2 11112 Et 3-SMeF 2 11113 Et 4-SMeF 2 11114 Et 2-SCF.sub.3 2 11115 Et 3-SCF.sub.3 2 11116 Et 4-SCF.sub.3 2 11117 Et 2-SEtF 2 11118 Et 3-SEtF 2 11119 Et 4-SEtF 2 11120 Et 2-SPrF 2 11121 Et 3-SPrF 2 11122 Et 4-SPrF 2 11123 Et 2-OMe, 4-OMe 2 11124 Et 2-Me, 5-OH 2 11125 Et 2-Me, 5-OMe 2 11126 Et 2-Me, 5-OMeF 2 11127 Et 2-Me, 5-OEtF 2 11128 Et 2-Me, 5-OPrF 2 11129 Et 2-Me, 4-OH 2 11130 Et 2-Me, 4-OMe 2 11131 Et 2-Me, 4-OMeF 2 11132 Et 2-Me, 4-OCF.sub.3 2 11133 Et 2-Me, 4-OEtF 2 11134 Et 2-Me, 4-OPrF 2 11135 Et 2-OH, 4-Me 2 11136 Et 2-OMe, 4-Me 2 11137 Et 2-OMeF, 4-Me 2 11138 Et 2-OCF.sub.3, 4-Me 2 11139 Et 2-OEtF, 4-Me 2 11140 Et 2-OPrF, 4-Me 2 11141 Et 2-Cl, 4-OH 2 11142 Et 2-Cl, 4-OMe 2 11143 Et 2-Cl, 4-OMeF 2 11144 Et 2-Cl, 4-OCF.sub.3 2 11145 Et 2-Cl, 4-OEtF 2 11146 Et 2-Cl, 4-OPrF 2 11147 Et 2-F, 4-F 2 11148 Et 2-Cl, 4-Cl 2 11149 Et 2-Cl, 4-F 2 11150 Et 2-Cl, 4-NO.sub.2 2 11151 Et 2-Cl, 4-NH.sub.2 2 11152 Et 2-Cl, 4-NHMe 2 11153 Et 2-Cl, 4-NMe.sub.2 2 11154 Et 2-Cl, 4-NMe.sub.3OTf 2 11155 Et 2-Cl, 4-NMe.sub.3I 2 11156 Et 2-Cl, 5-F 2 11157 Et 2-Cl, 5-NO.sub.2 2 11158 Et 2-Cl, 5-NH.sub.2 2 11159 Et 2-Cl, 5-NHMe 2 11160 Et 2-Cl, 5-NMe.sub.2 2 11161 Et 2-Cl, 5-NMe.sub.3OTf 2 11162 Et 2-Cl, 5-NMe.sub.3I 2 11163 Et 2-F, 4-Cl 2 11164 Et 2-NO.sub.2, 4-Cl 2 11165 Et 2-NH.sub.2, 4-Cl 2 11166 Et 2-NHMe, 4-Cl 2 11167 Et 2-NMe.sub.2, 4-Cl 2 11168 Et 2-NMe.sub.3OTf, 4-Cl 2 11169 Et 2-NMe.sub.3I, 4-Cl 2 11170 Et 2-F, 5-Cl 2 11171 Et 2-NO.sub.2, 5-Cl 2 11172 Et 2-NH.sub.2, 5-Cl 2 11173 Et 2-NHMe, 5-Cl 2 11174 Et 2-NMe.sub.2, 5-Cl 2 11175 Et 2-NMe.sub.3OTf, 5-Cl 2 11176 Et 2-NMe.sub.3I, 5-Cl 2 11177 Et 2-Br, 4-F 2 11178 Et 2-Br, 4-NO.sub.2 2 11179 Et 2-Br, 4-NH.sub.2 2 11180 Et 2-Br, 4-NHMe 2 11181 Et 2-Br, 4-NMe.sub.2 2 11182 Et 2-Br, 4-NMe.sub.3OTf 2 11183 Et 2-Br, 4-NMe.sub.3I 2 11184 Et 2-Br, 5-F 2 11185 Et 2-Br, 5-NO.sub.2 2 11186 Et 2-Br, 5-NH.sub.2 2 11187 Et 2-Br, 5-NHMe 2 11188 Et 2-Br, 5-NMe.sub.2 2 11189 Et 2-Br, 5-NMe.sub.3OTf 2 11190 Et 2-Br, 5-NMe.sub.3I 2 11191 Et 2-F, 4-Br 2 11192 Et 2-NO.sub.2, 4-Br 2 11193 Et 2-NH.sub.2, 4-Br 2 11194 Et 2-NHMe, 4-Br 2 11195 Et 2-NMe.sub.2, 4-Br 2 11196 Et 2-NMe.sub.3OTf, 4-Br 2 11197 Et 2-NMe.sub.3I, 4-Br 2 11198 Et 2-I, 4-F 2 11199 Et 2-I, 4-NO.sub.2 2 11200 Et 2-I, 4-NH.sub.2 2 11201 Et 2-I, 4-NHMe 2 11202 Et 2-I, 4-NMe.sub.2 2 11203 Et 2-I, 4-NMe.sub.3OTf 2 11204 Et 2-I, 4-NMe.sub.3I 2 11205 Et 2-F, 4-I 2 11206 Et 2-NO.sub.2, 4-I 2 11207 Et 2-NH.sub.2, 4-I 2 11208 Et 2-NHMe, 4-I 2 11209 Et 2-NMe.sub.2, 4-I 2 11210 Et 2-NMe.sub.3OTf, 4-I 2 11211 Et 2-NMe.sub.3I, 4-I 2 11212 Et 2-Me, 3-F 2 11213 Et 2-Me, 3-NO.sub.2 2 11214 Et 2-Me, 3-NH.sub.2 2 11215 Et 2-Me, 3-NHMe 2 11216 Et 2-Me, 3-NMe.sub.2 2 11217 Et 2-Me, 3-NMe.sub.3OTf 2 11218 Et 2-Me, 3-NMe.sub.3I 2

11219 Et 2-Me, 4-F 2 11220 Et 2-Me, 4-NO.sub.2 2 11221 Et 2-Me, 4-NH.sub.2 2 11222 Et 2-Me, 4-NHMe 2 11223 Et 2-Me, 4-NMe.sub.2 2 11224 Et 2-Me, 4-NMe.sub.3OTf 2 11225 Et 2-Me, 4-NMe.sub.3I 2 11226 Et 2-Me, 5-F 2 11227 Et 2-Me, 5-NO.sub.2 2 11228 Et 2-Me, 5-NH.sub.2 2 11229 Et 2-Me, 5-NHMe 2 11230 Et 2-Me, 5-NMe.sub.2 2 11231 Et 2-Me, 5-NMe.sub.3OTf 2 11232 Et 2-Me, 5-NMe.sub.3I 2 11233 Et 2-F, 4-Me 2 11234 Et 2-NO.sub.2, 4-Me 2 11235 Et 2-NH.sub.2, 4-Me 2 11236 Et 2-NHMe, 4-Me 2 11237 Et 2-NMe.sub.2, 4-Me 2 11238 Et 2-NMe.sub.3, 4-Me 2 11239 Et 2-NMe.sub.3OTf, 4-Me 2 11240 Et 2-NMe.sub.3I, 4-Me 2 11241 Et 2-SnMe.sub.3, 4-F 2 11242 Et 2-SnMe.sub.3, 5-F 2 11243 Et 2-F, 4-SnMe.sub.3 2 11244 Et 2-Br, 6-Cl, 4-F 2 11245 Et 2-Br, 6-Cl, 4-NO.sub.2 2 11246 Et 2-Br, 6-Cl, 4-NH.sub.2 2 11247 Et 2-Br, 6-Cl, 4- 2 NHMe 11248 Et 2-Br, 6-Cl, 4-NMe.sub.2 2 11249 Et 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 11250 Et 2-Br, 6-Cl, 4- 2 NMe.sub.3I 11251 Et 2-Me, 6-Cl, 4-F 2 11252 Et 2-SnMe.sub.3, 6-Cl, 4-F 2 11253 Et 2-Cl, 4-Me 2 11254 Et 2-Cl, 4-Br 2 11255 Et 2-Cl, 4-SnMe.sub.3 2 11256 Et 2-Br, 4-Cl 2 11257 Et 2-SnMe.sub.3, 4-Cl 2 11258 Et 2-Me, 4-Cl 2 11259 Et 2-Br, 4-Br 2 11260 Et 2-Br, 4-Me 2 11261 Et 2-Br, 4-SnMe.sub.3 2 11262 Et 2-SnMe.sub.3, 4-Br 2 11263 Et 2-Me, 4-Br 2 11264 Et 2-Me, 4-SnMe.sub.3 2 11265 Et 2-SnMe.sub.3, 4-Me 2 11266 Et 2-Me, 4-Me 2 11267 Et 2-Et, 4-Br 2 11268 Et 2-Et, 4-SnMe.sub.3 2 11269 Et 2-Et, 4-Me 2 11270 Et 2-Me, 4-Me, 6-Me 2 11271 Et 2-Me, 4-Br, 6-Me 2 11272 Et 2-Me, 4-SnMe.sub.3, 6- 2 Me 11273 Et 2-Et, 6-Me 2 11274 Et 2-Br, 4-i-Pr 2 11275 Et 2-SnMe.sub.3, 4-i-Pr 2 11276 Et 2-Me, 4-i-Pr 2 11277 Et 2-Br, 4-Br, 6-Br 2 11278 Et 2-Br, 4-Me, 6-Br 2 11279 Et 2-Br, 4-SnMe.sub.3, 6- 2 Br 11280 Et 2-SnMe.sub.3, 4-Br, 6- 2 Br 11281 Et 2-Br, 4-Br, 6-Me 2 11282 Et 2-Br, 4-CF.sub.3, 6-Br 2 11283 Et 2-Br, 4-Br, 6-CF.sub.3 2 11284 Et 2-CF.sub.3, 4-CF.sub.3 2 11285 Et 2-Cl, 4-CF.sub.3 2 11286 Et 2-CF.sub.3, 4-Cl 2 11287 Et 2-Br, 4-CF.sub.3 2 11288 Et 2-SnMe.sub.3, 4-CF.sub.3 2 11289 Et 2-Me, 4-CF.sub.3 2 11290 Et 2-CF.sub.3, 4-Br 2 11291 Et 2-CF.sub.3, 4-SnMe.sub.3 2 11292 Et 2-CF.sub.3, 4-Me 2 11293 Et 2-Br, 4-OH 2 11294 Et 2-Br, 4-OMe 2 11295 Et 2-Br, 4-OMeF 2 11296 Et 2-Br, 4-OCF.sub.3 2 11297 Et 2-Br, 4-OEtF 2 11298 Et 2-Br, 4-OPrF 2 11299 Et 2-OH, 4-Br 2 11300 Et 2-OMe, 4-Br 2 11301 Et 2-OMeF, 4-Br 2 11302 Et 2-OCF.sub.3, 4-Br 2 11303 Et 2-OEtF, 4-Br 2 11304 Et 2-OPrF, 4-Br 2 11305 Et 2-I, 4-OH 2 11306 Et 2-I, 4-OMe 2 11307 Et 2-I, 4-OMeF 2 11308 Et 2-I, 4-OCF.sub.3 2 11309 Et 2-I, 4-OEtF 2 11310 Et 2-I, 4-OPrF 2 11311 Et 2-OH, 4-I 2 11312 Et 2-OMe, 4-I 2 11313 Et 2-OMeF, 4-I 2 11314 Et 2-OCF.sub.3, 4-I 2 11315 Et 2-OEtF, 4-I 2 11316 Et 2-OPrF, 4-I 2 11317 Et 2-SnMe.sub.3, 4-OH 2 11318 Et 2-SnMe.sub.3, 4-OMe 2 11319 Et 2-SnMe.sub.3, 4-OMeF 2 11320 Et 2-SnMe.sub.3, 4-OCF.sub.3 2 11321 Et 2-SnMe.sub.3, 4-OEtF 2 11322 Et 2-SnMe.sub.3, 4-OPrF 2 11323 Et 2-OH, 4-SnMe.sub.3 2 11324 Et 2-OMe, 4-SnMe.sub.3 2 11325 Et 2-OMeF, 4-SnMe.sub.3 2 11326 Et 2-OCF.sub.3, 4-SnMe.sub.3 2 11327 Et 2-OEtF, 4-SnMe.sub.3 2 11328 Et 2-OPrF, 4-SnMe.sub.3 2 11329 Et--F H 1 11330 Et--F 2-t-Bu 1 11331 Et--F 2-Br 1 11332 Et--F 3-Br 1 11333 Et--F 4-Br 1 11334 Et--F 2-I 1 11335 Et--F 3-I 1 11336 Et--F 4-I 1 11337 Et--F 2-SnMe.sub.3 1 11338 Et--F 3-SnMe.sub.3 1 11339 Et--F 4-SnMe.sub.3 1 11340 Et--F 2-Me 1 11341 Et--F 3-Me 1 11342 Et--F 4-Me 1 11343 Et--F 2-OH 1 11344 Et--F 3-OH 1 11345 Et--F 4-OH 1 11346 Et--F 2-OMe 1 11347 Et--F 3-OMe 1 11348 Et--F 4-OMe 1 11349 Et--F 2-OMeF 1 11350 Et--F 3-OMeF 1 11351 Et--F 4-OMeF 1 11352 Et--F 2-OCF.sub.3 1 11353 Et--F 3-OCF.sub.3 1 11354 Et--F 4-OCF.sub.3 1 11355 Et--F 2-OEtF 1 11356 Et--F 3-OEtF 1 11357 Et--F 4-OEtF 1 11358 Et--F 2-OPrF 1 11359 Et--F 3-OPrF 1 11360 Et--F 4-OPrF 1 11361 Et--F 2-SH 1 11362 Et--F 3-SH 1 11363 Et--F 4-SH 1 11364 Et--F 2-SMe 1 11365 Et--F 3-SMe 1 11366 Et--F 4-SMe 1 11367 Et--F 2-SMeF 1 11368 Et--F 3-SMeF 1 11369 Et--F 4-SMeF 1 11370 Et--F 2-SCF.sub.3 1 11371 Et--F 3-SCF.sub.3 1 11372 Et--F 4-SCF.sub.3 1 11373 Et--F 2-SEtF 1 11374 Et--F 3-SEtF 1 11375 Et--F 4-SEtF 1 11376 Et--F 2-SPrF 1 11377 Et--F 3-SPrF 1 11378 Et--F 4-SPrF 1 11379 Et--F 2-OMe, 4-OMe 1 11380 Et--F 2-Me, 5-OH 1 11381 Et--F 2-Me, 5-OMe 1 11382 Et--F 2-Me, 5-OMeF 1 11383 Et--F 2-Me, 5-OEtF 1 11384 Et--F 2-Me, 5-OPrF 1 11385 Et--F 2-Me, 4-OH 1 11386 Et--F 2-Me, 4-OMe 1 11387 Et--F 2-Me, 4-OMeF 1 11388 Et--F 2-Me, 4-OCF.sub.3 1 11389 Et--F 2-Me, 4-OEtF 1 11390 Et--F 2-Me, 4-OPrF 1 11391 Et--F 2-OH, 4-Me 1 11392 Et--F 2-OMe, 4-Me 1 11393 Et--F 2-OMeF, 4-Me 1 11394 Et--F 2-OCF.sub.3, 4-Me 1 11395 Et--F 2-OEtF, 4-Me 1 11396 Et--F 2-OPrF, 4-Me 1 11397 Et--F 2-Cl, 4-OH 1 11398 Et--F 2-Cl, 4-OMe 1 11399 Et--F 2-Cl, 4-OMeF 1 11400 Et--F 2-Cl, 4-OCF.sub.3 1 11401 Et--F 2-Cl, 4-OEtF 1 11402 Et--F 2-Cl, 4-OPrF 1 11403 Et--F 2-F, 4-F 1 11404 Et--F 2-Cl, 4-Cl 1 11405 Et--F 2-Cl, 4-F 1 11406 Et--F 2-Cl, 4-NO.sub.2 1 11407 Et--F 2-Cl, 4-NH.sub.2 1 11408 Et--F 2-Cl, 4-NHMe 1 11409 Et--F 2-Cl, 4-NMe.sub.2 1 11410 Et--F 2-Cl, 4-NMe.sub.3OTf 1 11411 Et--F 2-Cl, 4-NMe.sub.3I 1 11412 Et--F 2-Cl, 5-F 1 11413 Et--F 2-Cl, 5-NO.sub.2 1 11414 Et--F 2-Cl, 5-NH.sub.2 1 11415 Et--F 2-Cl, 5-NHMe 1 11416 Et--F 2-Cl, 5-NMe.sub.2 1 11417 Et--F 2-Cl, 5-NMe.sub.3OTf 1 11418 Et--F 2-Cl, 5-NMe.sub.3I 1 11419 Et--F 2-F, 4-Cl 1 11420 Et--F 2-NO.sub.2, 4-Cl 1 11421 Et--F 2-NH.sub.2, 4-Cl 1 11422 Et--F 2-NHMe, 4-Cl 1 11423 Et--F 2-NMe.sub.2, 4-Cl 1 11424 Et--F 2-NMe.sub.3OTf, 4-Cl 1 11425 Et--F 2-NMe.sub.3I, 4-Cl 1 11426 Et--F 2-F, 5-Cl 1 11427 Et--F 2-NO.sub.2, 5-Cl 1 11428 Et--F 2-NH.sub.2, 5-Cl 1 11429 Et--F 2-NHMe, 5-Cl 1 11430 Et--F 2-NMe.sub.2, 5-Cl 1 11431 Et--F 2-NMe.sub.3OTf, 5-Cl 1 11432 Et--F 2-NMe.sub.3I, 5-Cl 1 11433 Et--F 2-Br, 4-F 1 11434 Et--F 2-Br, 4-NO.sub.2 1 11435 Et--F 2-Br, 4-NH.sub.2 1 11436 Et--F 2-Br, 4-NHMe 1 11437 Et--F 2-Br, 4-NMe.sub.2 1 11438 Et--F 2-Br, 4-NMe.sub.3OTf 1 11439 Et--F 2-Br, 4-NMe.sub.3I 1 11440 Et--F 2-Br, 5-F 1 11441 Et--F 2-Br, 5-NO.sub.2 1 11442 Et--F 2-Br, 5-NH.sub.2 1 11443 Et--F 2-Br, 5-NHMe 1 11444 Et--F 2-Br, 5-NMe.sub.2 1 11445 Et--F 2-Br, 5-NMe.sub.3OTf 1 11446 Et--F 2-Br, 5-NMe.sub.3I 1 11447 Et--F 2-F, 4-Br 1 11448 Et--F 2-NO.sub.2, 4-Br 1 11449 Et--F 2-NH.sub.2, 4-Br 1 11450 Et--F 2-NHMe, 4-Br 1 11451 Et--F 2-NMe.sub.2, 4-Br 1 11452 Et--F 2-NMe.sub.3OTf, 4-Br 1 11453 Et--F 2-NMe.sub.3I, 4-Br 1 11454 Et--F 2-I, 4-F 1 11455 Et--F 2-I, 4-NO.sub.2 1 11456 Et--F 2-I, 4-NH.sub.2 1 11457 Et--F 2-I, 4-NHMe 1 11458 Et--F 2-I, 4-NMe.sub.2 1 11459 Et--F 2-I, 4-NMe.sub.3OTf 1 11460 Et--F 2-I, 4-NMe.sub.3I 1 11461 Et--F 2-F, 4-I 1 11462 Et--F 2-NO.sub.2, 4-I 1 11463 Et--F 2-NH.sub.2, 4-I 1

11464 Et--F 2-NHMe, 4-I 1 11465 Et--F 2-NMe.sub.2, 4-I 1 11466 Et--F 2-NMe.sub.3OTf, 4-I 1 11467 Et--F 2-NMe.sub.3I, 4-I 1 11468 Et--F 2-Me, 3-F 1 11469 Et--F 2-Me, 3-NO.sub.2 1 11470 Et--F 2-Me, 3-NH.sub.2 1 11471 Et--F 2-Me, 3-NHMe 1 11472 Et--F 2-Me, 3-NMe.sub.2 1 11473 Et--F 2-Me, 3-NMe.sub.3OTf 1 11474 Et--F 2-Me, 3-NMe.sub.3I 1 11475 Et--F 2-Me, 4-F 1 11476 Et--F 2-Me, 4-NO.sub.2 1 11477 Et--F 2-Me, 4-NH.sub.2 1 11478 Et--F 2-Me, 4-NHMe 1 11479 Et--F 2-Me, 4-NMe.sub.2 1 11480 Et--F 2-Me, 4-NMe.sub.3OTf 1 11481 Et--F 2-Me, 4-NMe.sub.3I 1 11482 Et--F 2-Me, 5-F 1 11483 Et--F 2-Me, 5-NO.sub.2 1 11484 Et--F 2-Me, 5-NH.sub.2 1 11485 Et--F 2-Me, 5-NHMe 1 11486 Et--F 2-Me, 5-NMe.sub.2 1 11487 Et--F 2-Me, 5-NMe.sub.3OTf 1 11488 Et--F 2-Me, 5-NMe.sub.3I 1 11489 Et--F 2-F, 4-Me 1 11490 Et--F 2-NO.sub.2, 4-Me 1 11491 Et--F 2-NH.sub.2, 4-Me 1 11492 Et--F 2-NHMe, 4-Me 1 11493 Et--F 2-NMe.sub.2, 4-Me 1 11494 Et--F 2-NMe.sub.3, 4-Me 1 11495 Et--F 2-NMe.sub.3OTf, 4-Me 1 11496 Et--F 2-NMe.sub.3I, 4-Me 1 11497 Et--F 2-SnMe.sub.3, 4-F 1 11498 Et--F 2-SnMe.sub.3, 5-F 1 11499 Et--F 2-F, 4-SnMe.sub.3 1 11500 Et--F 2-Br, 6-Cl, 4-F 1 11501 Et--F 2-Br, 6-Cl, 4-NO.sub.2 1 11502 Et--F 2-Br, 6-Cl, 4-NH.sub.2 1 11503 Et--F 2-Br, 6-Cl, 4- 1 NHMe 11504 Et--F 2-Br, 6-Cl, 4-NMe.sub.2 1 11505 Et--F 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 11506 Et--F 2-Br, 6-Cl, 4- 1 NMe.sub.3I 11507 Et--F 2-Me, 6-Cl, 4-F 1 11508 Et--F 2-SnMe.sub.3, 6-Cl, 4-F 1 11509 Et--F 2-Cl, 4-Me 1 11510 Et--F 2-Cl, 4-Br 1 11511 Et--F 2-Cl, 4-SnMe.sub.3 1 11512 Et--F 2-Br, 4-Cl 1 11513 Et--F 2-SnMe.sub.3, 4-Cl 1 11514 Et--F 2-Me, 4-Cl 1 11515 Et--F 2-Br, 4-Br 1 11516 Et--F 2-Br, 4-Me 1 11517 Et--F 2-Br, 4-SnMe.sub.3 1 11518 Et--F 2-SnMe.sub.3, 4-Br 1 11519 Et--F 2-Me, 4-Br 1 11520 Et--F 2-Me, 4-SnMe.sub.3 1 11521 Et--F 2-SnMe.sub.3, 4-Me 1 11522 Et--F 2-Me, 4-Me 1 11523 Et--F 2-Et, 4-Br 1 11524 Et--F 2-Et, 4-SnMe.sub.3 1 11525 Et--F 2-Et, 4-Me 1 11526 Et--F 2-Me, 4-Me, 6-Me 1 11527 Et--F 2-Me, 4-Br, 6-Me 1 11528 Et--F 2-Me, 4-SnMe.sub.3, 6- 1 Me 11529 Et--F 2-Et, 6-Me 1 11530 Et--F 2-Br, 4-i-Pr 1 11531 Et--F 2-SnMe.sub.3, 4-i-Pr 1 11532 Et--F 2-Me, 4-i-Pr 1 11533 Et--F 2-Br, 4-Br, 6-Br 1 11534 Et--F 2-Br, 4-Me, 6-Br 1 11535 Et--F 2-Br, 4-SnMe.sub.3, 6- 1 Br 11536 Et--F 2-SnMe.sub.3, 4-Br, 6- 1 Br 11537 Et--F 2-Br, 4-Br, 6-Me 1 11538 Et--F 2-Br, 4-CF.sub.3, 6-Br 1 11539 Et--F 2-Br, 4-Br, 6-CF.sub.3 1 11540 Et--F 2-CF.sub.3, 4-CF.sub.3 1 11541 Et--F 2-Cl, 4-CF.sub.3 1 11542 Et--F 2-CF.sub.3, 4-Cl 1 11543 Et--F 2-Br, 4-CF.sub.3 1 11544 Et--F 2-SnMe.sub.3, 4-CF.sub.3 1 11545 Et--F 2-Me, 4-CF.sub.3 1 11546 Et--F 2-CF.sub.3, 4-Br 1 11547 Et--F 2-CF.sub.3, 4-SnMe.sub.3 1 11548 Et--F 2-CF.sub.3, 4-Me 1 11549 Et--F 2-Br, 4-OH 1 11550 Et--F 2-Br, 4-OMe 1 11551 Et--F 2-Br, 4-OMeF 1 11552 Et--F 2-Br, 4-OCF.sub.3 1 11553 Et--F 2-Br, 4-OEtF 1 11554 Et--F 2-Br, 4-OPrF 1 11555 Et--F 2-OH, 4-Br 1 11556 Et--F 2-OMe, 4-Br 1 11557 Et--F 2-OMeF, 4-Br 1 11558 Et--F 2-OCF.sub.3, 4-Br 1 11559 Et--F 2-OEtF, 4-Br 1 11560 Et--F 2-OPrF, 4-Br 1 11561 Et--F 2-I, 4-OH 1 11562 Et--F 2-I, 4-OMe 1 11563 Et--F 2-I, 4-OMeF 1 11564 Et--F 2-I, 4-OCF.sub.3 1 11565 Et--F 2-I, 4-OEtF 1 11566 Et--F 2-I, 4-OPrF 1 11567 Et--F 2-OH, 4-I 1 11568 Et--F 2-OMe, 4-I 1 11569 Et--F 2-OMeF, 4-I 1 11570 Et--F 2-OCF.sub.3, 4-I 1 11571 Et--F 2-OEtF, 4-I 1 11572 Et--F 2-OPrF, 4-I 1 11573 Et--F 2-SnMe.sub.3, 4-OH 1 11574 Et--F 2-SnMe.sub.3, 4-OMe 1 11575 Et--F 2-SnMe.sub.3, 4-OMeF 1 11576 Et--F 2-SnMe.sub.3, 4-OCF.sub.3 1 11577 Et--F 2-SnMe.sub.3, 4-OEtF 1 11578 Et--F 2-SnMe.sub.3, 4-OPrF 1 11579 Et--F 2-OH, 4-SnMe.sub.3 1 11580 Et--F 2-OMe, 4-SnMe.sub.3 1 11581 Et--F 2-OMeF, 4-SnMe.sub.3 1 11582 Et--F 2-OCF.sub.3, 4-SnMe.sub.3 1 11583 Et--F 2-OEtF, 4-SnMe.sub.3 1 11584 Et--F 2-OPrF, 4-SnMe.sub.3 1 11585 Et--F H 2 11586 Et--F 2-t-Bu 2 11587 Et--F 2-Br 2 11588 Et--F 3-Br 2 11589 Et--F 4-Br 2 11590 Et--F 2-I 2 11591 Et--F 3-I 2 11592 Et--F 4-I 2 11593 Et--F 2-SnMe.sub.3 2 11594 Et--F 3-SnMe.sub.3 2 11595 Et--F 4-SnMe.sub.3 2 11596 Et--F 2-Me 2 11597 Et--F 3-Me 2 11598 Et--F 4-Me 2 11599 Et--F 2-OH 2 11600 Et--F 3-OH 2 11601 Et--F 4-OH 2 11602 Et--F 2-OMe 2 11603 Et--F 3-OMe 2 11604 Et--F 4-OMe 2 11605 Et--F 2-OMeF 2 11606 Et--F 3-OMeF 2 11607 Et--F 4-OMeF 2 11608 Et--F 2-OCF.sub.3 2 11609 Et--F 3-OCF.sub.3 2 11610 Et--F 4-OCF.sub.3 2 11611 Et--F 2-OEtF 2 11612 Et--F 3-OEtE 2 11613 Et--F 4-OEtF 2 11614 Et--F 2-OPrF 2 11615 Et--F 3-OPrF 2 11616 Et--F 4-OPrF 2 11617 Et--F 2-SH 2 11618 Et--F 3-SH 2 11619 Et--F 4-SH 2 11620 Et--F 2-SMe 2 11621 Et--F 3-SMe 2 11622 Et--F 4-SMe 2 11623 Et--F 2-SMeF 2 11624 Et--F 3-SMeF 2 11625 Et--F 4-SMeF 2 11626 Et--F 2-SCF.sub.3 2 11627 Et--F 3-SCF.sub.3 2 11628 Et--F 4-SCF.sub.3 2 11629 Et--F 2-SEtF 2 11630 Et--F 3-SEtF 2 11631 Et--F 4-SEtF 2 11632 Et--F 2-SPrF 2 11633 Et--F 3-SPrF 2 11634 Et--F 4-SPrF 2 11635 Et--F 2-OMe, 4-OMe 2 11636 Et--F 2-Me, 5-OH 2 11637 Et--F 2-Me, 5-OMe 2 11638 Et--F 2-Me, 5-OMeF 2 11639 Et--F 2-Me, 5-OEtF 2 11640 Et--F 2-Me, 5-OPrF 2 11641 Et--F 2-Me, 4-OH 2 11642 Et--F 2-Me, 4-OMe 2 11643 Et--F 2-Me, 4-OMeF 2 11644 Et--F 2-Me, 4-OCF.sub.3 2 11645 Et--F 2-Me, 4-OEtF 2 11646 Et--F 2-Me, 4-OPrF 2 11647 Et--F 2-OH, 4-Me 2 11648 Et--F 2-OMe, 4-Me 2 11649 Et--F 2-OMeF, 4-Me 2 11650 Et--F 2-OCF.sub.3, 4-Me 2 11651 Et--F 2-OEtF, 4-Me 2 11652 Et--F 2-OPrF, 4-Me 2 11653 Et--F 2-Cl, 4-OH 2 11654 Et--F 2-Cl, 4-OMe 2 11655 Et--F 2-Cl, 4-OMeF 2 11656 Et--F 2-Cl, 4-OCF.sub.3 2 11657 Et--F 2-Cl, 4-OEtF 2 11658 Et--F 2-Cl, 4-OPrF 2 11659 Et--F 2-F, 4-F 2 11660 Et--F 2-Cl, 4-Cl 2 11661 Et--F 2-Cl, 4-F 2 11662 Et--F 2-Cl, 4-NO.sub.2 2 11663 Et--F 2-Cl, 4-NH.sub.2 2 11664 Et--F 2-Cl, 4-NHMe 2 11665 Et--F 2-Cl, 4-NMe.sub.2 2 11666 Et--F 2-Cl, 4-NMe.sub.3OTf 2 11667 Et--F 2-Cl, 4-NMe.sub.3I 2 11668 Et--F 2-Cl, 5-F 2 11669 Et--F 2-Cl, 5-NO.sub.2 2 11670 Et--F 2-Cl, 5-NH.sub.2 2 11671 Et--F 2-Cl, 5-NHMe 2 11672 Et--F 2-Cl, 5-NMe.sub.2 2 11673 Et--F 2-Cl, 5-NMe.sub.3OTf 2 11674 Et--F 2-Cl, 5-NMe.sub.3I 2 11675 Et--F 2-F, 4-Cl 2 11676 Et--F 2-NO.sub.2, 4-Cl 2 11677 Et--F 2-NH.sub.2, 4-Cl 2 11678 Et--F 2-NHMe, 4-Cl 2 11679 Et--F 2-NMe.sub.2, 4-Cl 2 11680 Et--F 2-NMe.sub.3OTf, 4-Cl 2 11681 Et--F 2-NMe.sub.3I, 4-Cl 2 11682 Et--F 2-F, 5-Cl 2 11683 Et--F 2-NO.sub.2, 5-Cl 2 11684 Et--F 2-NH.sub.2, 5-Cl 2 11685 Et--F 2-NHMe, 5-Cl 2 11686 Et--F 2-NMe.sub.2, 5-Cl 2 11687 Et--F 2-NMe.sub.3OTf, 5-Cl 2 11688 Et--F 2-NMe.sub.3I, 5-Cl 2 11689 Et--F 2-Br, 4-F 2 11690 Et--F 2-Br, 4-NO.sub.2 2 11691 Et--F 2-Br, 4-NH.sub.2 2 11692 Et--F 2-Br, 4-NHMe 2 11693 Et--F 2-Br, 4-NMe.sub.2 2 11694 Et--F 2-Br, 4-NMe.sub.3OTf 2 11695 Et--F 2-Br, 4-NMe.sub.3I 2 11696 Et--F 2-Br, 5-F 2 11697 Et--F 2-Br, 5-NO.sub.2 2 11698 Et--F 2-Br, 5-NH.sub.2 2 11699 Et--F 2-Br, 5-NHMe 2 11700 Et--F 2-Br, 5-NMe.sub.2 2 11701 Et--F 2-Br, 5-NMe.sub.3OTf 2 11702 Et--F 2-Br, 5-NMe.sub.3I 2 11703 Et--F 2-F, 4-Br 2 11704 Et--F 2-NO.sub.2, 4-Br 2 11705 Et--F 2-NH.sub.2, 4-Br 2 11706 Et--F 2-NHMe, 4-Br 2 11707 Et--F 2-NMe.sub.2, 4-Br 2 11708 Et--F 2-NMe.sub.3OTf, 4-Br 2

11709 Et--F 2-NMe.sub.3I, 4-Br 2 11710 Et--F 2-I, 4-F 2 11711 Et--F 2-I, 4-NO.sub.2 2 11712 Et--F 2-I, 4-NH.sub.2 2 11713 Et--F 2-I, 4-NHMe 2 11714 Et--F 2-I, 4-NMe.sub.2 2 11715 Et--F 2-I, 4-NMe.sub.3OTf 2 11716 Et--F 2-I, 4-NMe.sub.3I 2 11717 Et--F 2-F, 4-I 2 11718 Et--F 2-NO.sub.2, 4-I 2 11719 Et--F 2-NH.sub.2, 4-I 2 11720 Et--F 2-NHMe, 4-I 2 11721 Et--F 2-NMe.sub.2, 4-I 2 11722 Et--F 2-NMe.sub.3OTf, 4-I 2 11723 Et--F 2-NMe.sub.3I, 4-I 2 11724 Et--F 2-Me, 3-F 2 11725 Et--F 2-Me, 3-NO.sub.2 2 11726 Et--F 2-Me, 3-NH.sub.2 2 11727 Et--F 2-Me, 3-NHMe 2 11728 Et--F 2-Me, 3-NMe.sub.2 2 11729 Et--F 2-Me, 3-NMe.sub.3OTf 2 11730 Et--F 2-Me, 3-NMe.sub.3I 2 11731 Et--F 2-Me, 4-F 2 11732 Et--F 2-Me, 4-NO.sub.2 2 11733 Et--F 2-Me, 4-NH.sub.2 2 11734 Et--F 2-Me, 4-NHMe 2 11735 Et--F 2-Me, 4-NMe.sub.2 2 11736 Et--F 2-Me, 4-NMe.sub.3OTf 2 11737 Et--F 2-Me, 4-NMe.sub.3I 2 11738 Et--F 2-Me, 5-F 2 11739 Et--F 2-Me, 5-NO.sub.2 2 11740 Et--F 2-Me, 5-NH.sub.2 2 11741 Et--F 2-Me, 5-NHMe 2 11742 Et--F 2-Me, 5-NMe.sub.2 2 11743 Et--F 2-Me, 5-NMe.sub.3OTf 2 11744 Et--F 2-Me, 5-NMe.sub.3I 2 11745 Et--F 2-F, 4-Me 2 11746 Et--F 2-NO.sub.2, 4-Me 2 11747 Et--F 2-NH.sub.2, 4-Me 2 11748 Et--F 2-NHMe, 4-Me 2 11749 Et--F 2-NMe.sub.2, 4-Me 2 11750 Et--F 2-NMe.sub.3, 4-Me 2 11751 Et--F 2-NMe.sub.3OTf, 4-Me 2 11752 Et--F 2-NMe.sub.3I, 4-Me 2 11753 Et--F 2-SnMe.sub.3, 4-F 2 11754 Et--F 2-SnMe.sub.3, 5-F 2 11755 Et--F 2-F, 4-SnMe.sub.3 2 11756 Et--F 2-Br, 6-Cl, 4-F 2 11757 Et--F 2-Br, 6-Cl, 4-NO.sub.2 2 11758 Et--F 2-Br, 6-Cl, 4-NH.sub.2 2 11759 Et--F 2-Br, 6-Cl, 4- 2 NHMe 11760 Et--F 2-Br, 6-Cl, 4-NMe.sub.2 2 11761 Et--F 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 11762 Et--F 2-Br, 6-Cl, 4- 2 NMe.sub.3I 11763 Et--F 2-Me, 6-Cl, 4-F 2 11764 Et--F 2-SnMe.sub.3, 6-Cl, 4-F 2 11765 Et--F 2-Cl, 4-Me 2 11766 Et--F 2-Cl, 4-Br 2 11767 Et--F 2-Cl, 4-SnMe.sub.3 2 11768 Et--F 2-Br, 4-Cl 2 11769 Et--F 2-SnMe.sub.3, 4-Cl 2 11770 Et--F 2-Me, 4-Cl 2 11771 Et--F 2-Br, 4-Br 2 11772 Et--F 2-Br, 4-Me 2 11773 Et--F 2-Br, 4-SnMe.sub.3 2 11774 Et--F 2-SnMe.sub.3, 4-Br 2 11775 Et--F 2-Me, 4-Br 2 11776 Et--F 2-Me, 4-SnMe.sub.3 2 11777 Et--F 2-SnMe.sub.3, 4-Me 2 11778 Et--F 2-Me, 4-Me 2 11779 Et--F 2-Et, 4-Br 2 11780 Et--F 2-Et, 4-SnMe.sub.3 2 11781 Et--F 2-Et, 4-Me 2 11782 Et--F 2-Me, 4-Me, 6-Me 2 11783 Et--F 2-Me, 4-Br, 6-Me 2 11784 Et--F 2-Me, 4-SnMe.sub.3, 6- 2 Me 11785 Et--F 2-Et, 6-Me 2 11786 Et--F 2-Br, 4-i-Pr 2 11787 Et--F 2-SnMe.sub.3, 4-i-Pr 2 11788 Et--F 2-Me, 4-i-Pr 2 11789 Et--F 2-Br, 4-Br, 6-Br 2 11790 Et--F 2-Br, 4-Me, 6-Br 2 11791 Et--F 2-Br, 4-SnMe.sub.3, 6- 2 Br 11792 Et--F 2-SnMe.sub.3, 4-Br, 6- 2 Br 11793 Et--F 2-Br, 4-Br, 6-Me 2 11794 Et--F 2-Br, 4-CF.sub.3, 6-Br 2 11795 Et--F 2-Br, 4-Br, 6-CF.sub.3 2 11796 Et--F 2-CF.sub.3, 4-CF.sub.3 2 11797 Et--F 2-Cl, 4-CF.sub.3 2 11798 Et--F 2-CF.sub.3, 4-Cl 2 11799 Et--F 2-Br, 4-CF.sub.3 2 11800 Et--F 2-SnMe.sub.3, 4-CF.sub.3 2 11801 Et--F 2-Me, 4-CF.sub.3 2 11802 Et--F 2-CF.sub.3, 4-Br 2 11803 Et--F 2-CF.sub.3, 4-SnMe.sub.3 2 11804 Et--F 2-CF.sub.3, 4-Me 2 11805 Et--F 2-Br, 4-OH 2 11806 Et--F 2-Br, 4-OMe 2 11807 Et--F 2-Br, 4-OMeF 2 11808 Et--F 2-Br, 4-OCF.sub.3 2 11809 Et--F 2-Br, 4-OEtF 2 11810 Et--F 2-Br, 4-OPrF 2 11811 Et--F 2-OH, 4-Br 2 11812 Et--F 2-OMe, 4-Br 2 11813 Et--F 2-OMeF, 4-Br 2 11814 Et--F 2-OCF.sub.3, 4-Br 2 11815 Et--F 2-OEtF, 4-Br 2 11816 Et--F 2-OPrF, 4-Br 2 11817 Et--F 2-I, 4-OH 2 11818 Et--F 2-I, 4-OMe 2 11819 Et--F 2-I, 4-OMeF 2 11820 Et--F 2-I, 4-OCF.sub.3 2 11821 Et--F 2-I, 4-OEtF 2 11822 Et--F 2-I, 4-OPrF 2 11823 Et--F 2-OH, 4-I 2 11824 Et--F 2-OMe, 4-I 2 11825 Et--F 2-OMeF, 4-I 2 11826 Et--F 2-OCF.sub.3, 4-I 2 11827 Et--F 2-OEtF, 4-I 2 11828 Et--F 2-OPrF, 4-I 2 11829 Et--F 2-SnMe.sub.3, 4-OH 2 11830 Et--F 2-SnMe.sub.3, 4-OMe 2 11831 Et--F 2-SnMe.sub.3, 4-OMeF 2 11832 Et--F 2-SnMe.sub.3, 4-OCF.sub.3 2 11833 Et--F 2-SnMe.sub.3, 4-OEtF 2 11834 Et--F 2-SnMe.sub.3, 4-OPrF 2 11835 Et--F 2-OH, 4-SnMe.sub.3 2 11836 Et--F 2-OMe, 4-SnMe.sub.3 2 11837 Et--F 2-OMeF, 4-SnMe.sub.3 2 11838 Et--F 2-OCF.sub.3, 4-SnMe.sub.3 2 11839 Et--F 2-OEtF, 4-SnMe.sub.3 2 11840 Et--F 2-OPrF, 4-SnMe.sub.3 2 11841 Me H 1 11842 Me 2-t-Bu 1 11843 Me 2-Br 1 11844 Me 3-Br 1 11845 Me 4-Br 1 11846 Me 2-I 1 11847 Me 3-I 1 11848 Me 4-I 1 11849 Me 2-SnMe.sub.3 1 11850 Me 3-SnMe.sub.3 1 11851 Me 4-SnMe.sub.3 1 11852 Me 2-Me 1 11853 Me 3-Me 1 11854 Me 4-Me 1 11855 Me 2-OH 1 11856 Me 3-OH 1 11857 Me 4-OH 1 11858 Me 2-OMe 1 11859 Me 3-OMe 1 11860 Me 4-OMe 1 11861 Me 2-OMeF 1 11862 Me 3-OMeF 1 11863 Me 4-OMeF 1 11864 Me 2-OCF.sub.3 1 11865 Me 3-OCF.sub.3 1 11866 Me 4-OCF.sub.3 1 11867 Me 2-OEtF 1 11868 Me 3-OEtF 1 11869 Me 4-OEtF 1 11870 Me 2-OPrF 1 11871 Me 3-OPrF 1 11872 Me 4-OPrF 1 11873 Me 2-SH 1 11874 Me 3-SH 1 11875 Me 4-SH 1 11876 Me 2-SMe 1 11877 Me 3-SMe 1 11878 Me 4-SMe 1 11879 Me 2-SMeF 1 11880 Me 3-SMeF 1 11881 Me 4-SMeF 1 11882 Me 2-SCF.sub.3 1 11883 Me 3-SCF.sub.3 1 11884 Me 4-SCF.sub.3 1 11885 Me 2-SEtF 1 11886 Me 3-SEtF 1 11887 Me 4-SEtF 1 11888 Me 2-SPrF 1 11889 Me 3-SPrF 1 11890 Me 4-SPrF 1 11891 Me 2-OMe, 4-OMe 1 11892 Me 2-Me, 5-OH 1 11893 Me 2-Me, 5-OMe 1 11894 Me 2-Me, 5-OMeF 1 11895 Me 2-Me, 5-OEtF 1 11896 Me 2-Me, 5-OPrF 1 11897 Me 2-Me, 4-OH 1 11898 Me 2-Me, 4-OMe 1 11899 Me 2-Me, 4-OMeF 1 11900 Me 2-Me, 4-OCF.sub.3 1 11901 Me 2-Me, 4-OEtF 1 11902 Me 2-Me, 4-OPrF 1 11903 Me 2-OH, 4-Me 1 11904 Me 2-OMe, 4-Me 1 11905 Me 2-OMeF, 4-Me 1 11906 Me 2-OCF.sub.3, 4-Me 1 11907 Me 2-OEtF, 4-Me 1 11908 Me 2-OPrF, 4-Me 1 11909 Me 2-Cl, 4-OH 1 11910 Me 2-Cl, 4-OMe 1 11911 Me 2-Cl, 4-OMeF 1 11912 Me 2-Cl, 4-OCF.sub.3 1 11913 Me 2-Cl, 4-OEtF 1 11914 Me 2-Cl, 4-OPrF 1 11915 Me 2-F, 4-F 1 11916 Me 2-Cl, 4-Cl 1 11917 Me 2-Cl, 4-F 1 11918 Me 2-Cl, 4-NO.sub.2 1 11919 Me 2-Cl, 4-NH.sub.2 1 11920 Me 2-Cl, 4-NHMe 1 11921 Me 2-Cl, 4-NMe.sub.2 1 11922 Me 2-Cl, 4-NMe.sub.3OTf 1 11923 Me 2-Cl, 4-NMe.sub.3I 1 11924 Me 2-Cl, 5-F 1 11925 Me 2-Cl, 5-NO.sub.2 1 11926 Me 2-Cl, 5-NH.sub.2 1 11927 Me 2-Cl, 5-NHMe 1 11928 Me 2-Cl, 5-NMe.sub.2 1 11929 Me 2-Cl, 5-NMe.sub.3OTf 1 11930 Me 2-Cl, 5-NMe.sub.3I 1 11931 Me 2-F, 4-Cl 1 11932 Me 2-NO.sub.2, 4-Cl 1 11933 Me 2-NH.sub.2, 4-Cl 1 11934 Me 2-NHMe, 4-Cl 1 11935 Me 2-NMe.sub.2, 4-Cl 1 11936 Me 2-NMe.sub.3OTf, 4-Cl 1 11937 Me 2-NMe.sub.3I, 4-Cl 1 11938 Me 2-F, 5-Cl 1 11939 Me 2-NO.sub.2, 5-Cl 1 11940 Me 2-NH.sub.2, 5-Cl 1 11941 Me 2-NHMe, 5-Cl 1 11942 Me 2-NMe.sub.2, 5-Cl 1 11943 Me 2-NMe.sub.3OTf, 5-Cl 1 11944 Me 2-NMe.sub.3I, 5-Cl 1 11945 Me 2-Br, 4-F 1 11946 Me 2-Br, 4-NO.sub.2 1 11947 Me 2-Br, 4-NH.sub.2 1 11948 Me 2-Br, 4-NHMe 1 11949 Me 2-Br, 4-NMe.sub.2 1 11950 Me 2-Br, 4-NMe.sub.3OTf 1 11951 Me 2-Br, 4-NMe.sub.3I 1 11952 Me 2-Br, 5-F 1 11953 Me 2-Br, 5-NO.sub.2 1

11954 Me 2-Br, 5-NH.sub.2 1 11955 Me 2-Br, 5-NHMe 1 11956 Me 2-Br, 5-NMe.sub.2 1 11957 Me 2-Br, 5-NMe.sub.3OTf 1 11958 Me 2-Br, 5-NMe.sub.3I 1 11959 Me 2-F, 4-Br 1 11960 Me 2-NO.sub.2, 4-Br 1 11961 Me 2-NH.sub.2, 4-Br 1 11962 Me 2-NHMe, 4-Br 1 11963 Me 2-NMe.sub.2, 4-Br 1 11964 Me 2-NMe.sub.3OTf, 4-Br 1 11965 Me 2-NMe.sub.3I, 4-Br 1 11966 Me 2-I, 4-F 1 11967 Me 2-I, 4-NO.sub.2 1 11968 Me 2-I, 4-NH.sub.2 1 11969 Me 2-I, 4-NHMe 1 11970 Me 2-I, 4-NMe.sub.2 1 11971 Me 2-I, 4-NMe.sub.3OTf 1 11972 Me 2-I, 4-NMe.sub.3I 1 11973 Me 2-F, 4-I 1 11974 Me 2-NO.sub.2, 4-I 1 11975 Me 2-NH.sub.2, 4-I 1 11976 Me 2-NHMe, 4-I 1 11977 Me 2-NMe.sub.2, 4-I 1 11978 Me 2-NMe.sub.3OTf, 4-I 1 11979 Me 2-NMe.sub.3I, 4-I 1 11980 Me 2-Me, 3-F 1 11981 Me 2-Me, 3-NO.sub.2 1 11982 Me 2-Me, 3-NH.sub.2 1 11983 Me 2-Me, 3-NHMe 1 11984 Me 2-Me, 3-NMe.sub.2 1 11985 Me 2-Me, 3-NMe.sub.3OTf 1 11986 Me 2-Me, 3-NMe.sub.3I 1 11987 Me 2-Me, 4-F 1 11988 Me 2-Me, 4-NO.sub.2 1 11989 Me 2-Me, 4-NH.sub.2 1 11990 Me 2-Me, 4-NHMe 1 11991 Me 2-Me, 4-NMe.sub.2 1 11992 Me 2-Me, 4-NMe.sub.3OTf 1 11993 Me 2-Me, 4-NMe.sub.3I 1 11994 Me 2-Me, 5-F 1 11995 Me 2-Me, 5-NO.sub.2 1 11996 Me 2-Me, 5-NH.sub.2 1 11997 Me 2-Me, 5-NHMe 1 11998 Me 2-Me, 5-NMe.sub.2 1 11999 Me 2-Me, 5-NMe.sub.3OTf 1 12000 Me 2-Me, 5-NMe.sub.3I 1 12001 Me 2-F, 4-Me 1 12002 Me 2-NO.sub.2, 4-Me 1 12003 Me 2-NH.sub.2, 4-Me 1 12004 Me 2-NHMe, 4-Me 1 12005 Me 2-NMe.sub.2, 4-Me 1 12006 Me 2-NMe.sub.3, 4-Me 1 12007 Me 2-NMe.sub.3OTf, 4-Me 1 12008 Me 2-NMe.sub.3I, 4-Me 1 12009 Me 2-SnMe.sub.3, 4-F 1 12010 Me 2-SnMe.sub.3, 5-F 1 12011 Me 2-F, 4-SnMe.sub.3 1 12012 Me 2-Br, 6-Cl, 4-F 1 12013 Me 2-Br, 6-Cl, 4-NO.sub.2 1 12014 Me 2-Br, 6-Cl, 4-NH.sub.2 1 12015 Me 2-Br, 6-Cl, 4- 1 NHMe 12016 Me 2-Br, 6-Cl, 4-NMe.sub.2 1 12017 Me 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 12018 Me 2-Br, 6-Cl, 4- 1 NMe.sub.3I 12019 Me 2-Me, 6-Cl, 4-F 1 12020 Me 2-SnMe.sub.3, 6-Cl, 4-F 1 12021 Me 2-Cl, 4-Me 1 12022 Me 2-Cl, 4-Br 1 12023 Me 2-Cl, 4-SnMe.sub.3 1 12024 Me 2-Br, 4-Cl 1 12025 Me 2-SnMe.sub.3, 4-Cl 1 12026 Me 2-Me, 4-Cl 1 12027 Me 2-Br, 4-Br 1 12028 Me 2-Br, 4-Me 1 12029 Me 2-Br, 4-SnMe.sub.3 1 12030 Me 2-SnMe.sub.3, 4-Br 1 12031 Me 2-Me, 4-Br 1 12032 Me 2-Me, 4-SnMe.sub.3 1 12033 Me 2-SnMe.sub.3, 4-Me 1 12034 Me 2-Me, 4-Me 1 12035 Me 2-Et, 4-Br 1 12036 Me 2-Et, 4-SnMe.sub.3 1 12037 Me 2-Et, 4-Me 1 12038 Me 2-Me, 4-Me, 6-Me 1 12039 Me 2-Me, 4-Br, 6-Me 1 12040 Me 2-Me, 4-SnMe.sub.3, 6- 1 Me 12041 Me 2-Et, 6-Me 1 12042 Me 2-Br, 4-i-Pr 1 12043 Me 2-SnMe.sub.3, 4-i-Pr 1 12044 Me 2-Me, 4-i-Pr 1 12045 Me 2-Br, 4-Br, 6-Br 1 12046 Me 2-Br, 4-Me, 6-Br 1 12047 Me 2-Br, 4-SnMe.sub.3, 6- 1 Br 12048 Me 2-SnMe.sub.3, 4-Br, 6- 1 Br 12049 Me 2-Br, 4-Br, 6-Me 1 12050 Me 2-Br, 4-CF.sub.3, 6-Br 1 12051 Me 2-Br, 4-Br, 6-CF.sub.3 1 12052 Me 2-CF.sub.3, 4-CF.sub.3 1 12053 Me 2-Cl, 4-CF.sub.3 1 12054 Me 2-CF.sub.3, 4-Cl 1 12055 Me 2-Br, 4-CF.sub.3 1 12056 Me 2-SnMe.sub.3, 4-CF.sub.3 1 12057 Me 2-Me, 4-CF.sub.3 1 12058 Me 2-CF.sub.3, 4-Br 1 12059 Me 2-CF.sub.3, 4-SnMe.sub.3 1 12060 Me 2-CF.sub.3, 4-Me 1 12061 Me 2-Br, 4-OH 1 12062 Me 2-Br, 4-OMe 1 12063 Me 2-Br, 4-OMeF 1 12064 Me 2-Br, 4-OCF.sub.3 1 12065 Me 2-Br, 4-OEtF 1 12066 Me 2-Br, 4-OPrF 1 12067 Me 2-OH, 4-Br 1 12068 Me 2-OMe, 4-Br 1 12069 Me 2-OMeF, 4-Br 1 12070 Me 2-OCF.sub.3, 4-Br 1 12071 Me 2-OEtF, 4-Br 1 12072 Me 2-OPrF, 4-Br 1 12073 Me 2-I, 4-OH 1 12074 Me 2-I, 4-OMe 1 12075 Me 2-I, 4-OMeF 1 12076 Me 2-I, 4-OCF.sub.3 1 12077 Me 2-I, 4-OEtF 1 12078 Me 2-I, 4-OPrF 1 12079 Me 2-OH, 4-I 1 12080 Me 2-OMe, 4-I 1 12081 Me 2-OMeF, 4-I 1 12082 Me 2-OCF.sub.3, 4-I 1 12083 Me 2-OEtF, 4-I 1 12084 Me 2-OPrF, 4-I 1 12085 Me 2-SnMe.sub.3, 4-OH 1 12086 Me 2-SnMe.sub.3, 4-OMe 1 12087 Me 2-SnMe.sub.3, 4-OMeF 1 12088 Me 2-SnMe.sub.3, 4-OCF.sub.3 1 12089 Me 2-SnMe.sub.3, 4-OEtF 1 12090 Me 2-SnMe.sub.3, 4-OPrF 1 12091 Me 2-OH, 4-SnMe.sub.3 1 12092 Me 2-OMe, 4-SnMe.sub.3 1 12093 Me 2-OMeF, 4-SnMe.sub.3 1 12094 Me 2-OCF.sub.3, 4-SnMe.sub.3 1 12095 Me 2-OEtF, 4-SnMe.sub.3 1 12096 Me 2-OPrF, 4-SnMe.sub.3 1 12097 Me H 2 12098 Me 2-t-Bu 2 12099 Me 2-Br 2 12100 Me 3-Br 2 12101 Me 4-Br 2 12102 Me 2-I 2 12103 Me 3-I 2 12104 Me 4-I 2 12105 Me 2-SnMe.sub.3 2 12106 Me 3-SnMe.sub.3 2 12107 Me 4-SnMe.sub.3 2 12108 Me 2-Me 2 12109 Me 3-Me 2 12110 Me 4-Me 2 12111 Me 2-OH 2 12112 Me 3-OH 2 12113 Me 4-OH 2 12114 Me 2-OMe 2 12115 Me 3-OMe 2 12116 Me 4-OMe 2 12117 Me 2-OMeF 2 12118 Me 3-OMeF 2 12119 Me 4-OMeF 2 12120 Me 2-OCF.sub.3 2 12121 Me 3-OCF.sub.3 2 12122 Me 4-OCF.sub.3 2 12123 Me 2-OEtF 2 12124 Me 3-OEtF 2 12125 Me 4-OEtF 2 12126 Me 2-OPrF 2 12127 Me 3-OPrF 2 12128 Me 4-OPrF 2 12129 Me 2-SH 2 12130 Me 3-SH 2 12131 Me 4-SH 2 12132 Me 2-SMe 2 12133 Me 3-SMe 2 12134 Me 4-SMe 2 12135 Me 2-SMeF 2 12136 Me 3-SMeF 2 12137 Me 4-SMeF 2 12138 Me 2-SCF.sub.3 2 12139 Me 3-SCF.sub.3 2 12140 Me 4-SCF.sub.3 2 12141 Me 2-SEtF 2 12142 Me 3-SEtF 2 12143 Me 4-SEtF 2 12144 Me 2-SPrF 2 12145 Me 3-SPrF 2 12146 Me 4-SPrF 2 12147 Me 2-OMe, 4-OMe 2 12148 Me 2-Me, 5-OH 2 12149 Me 2-Me, 5-OMe 2 12150 Me 2-Me, 5-OMeF 2 12151 Me 2-Me, 5-OEtF 2 12152 Me 2-Me, 5-OPrF 2 12153 Me 2-Me, 4-OH 2 12154 Me 2-Me, 4-OMe 2 12155 Me 2-Me, 4-OMeF 2 12156 Me 2-Me, 4-OCF.sub.3 2 12157 Me 2-Me, 4-OEtF 2 12158 Me 2-Me, 4-OPrF 2 12159 Me 2-OH, 4-Me 2 12160 Me 2-OMe, 4-Me 2 12161 Me 2-OMeF, 4-Me 2 12162 Me 2-OCF.sub.3, 4-Me 2 12163 Me 2-OEtF, 4-Me 2 12164 Me 2-OPrF, 4-Me 2 12165 Me 2-Cl, 4-OH 2 12166 Me 2-Cl, 4-OMe 2 12167 Me 2-Cl, 4-OMeF 2 12168 Me 2-Cl, 4-OCF.sub.3 2 12169 Me 2-Cl, 4-OEtF 2 12170 Me 2-Cl, 4-OPrF 2 12171 Me 2-F, 4-F 2 12172 Me 2-Cl, 4-Cl 2 12173 Me 2-Cl, 4-F 2 12174 Me 2-Cl, 4-NO.sub.2 2 12175 Me 2-Cl, 4-NH.sub.2 2 12176 Me 2-Cl, 4-NHMe 2 12177 Me 2-Cl, 4-NMe.sub.2 2 12178 Me 2-Cl, 4-NMe.sub.3OTf 2 12179 Me 2-Cl, 4-NMe.sub.3I 2 12180 Me 2-Cl, 5-F 2 12181 Me 2-Cl, 5-NO.sub.2 2 12182 Me 2-Cl, 5-NH.sub.2 2 12183 Me 2-Cl, 5-NHMe 2 12184 Me 2-Cl, 5-NMe.sub.2 2 12185 Me 2-Cl, 5-NMe.sub.3OTf 2 12186 Me 2-Cl, 5-NMe.sub.3I 2 12187 Me 2-F, 4-Cl 2 12188 Me 2-NO.sub.2, 4-Cl 2 12189 Me 2-NH.sub.2, 4-Cl 2 12190 Me 2-NHMe, 4-Cl 2 12191 Me 2-NMe.sub.2, 4-Cl 2 12192 Me 2-NMe.sub.3OTf, 4-Cl 2 12193 Me 2-NMe.sub.3I, 4-Cl 2 12194 Me 2-F, 5-Cl 2 12195 Me 2-NO.sub.2, 5-Cl 2 12196 Me 2-NH.sub.2, 5-Cl 2 12197 Me 2-NHMe, 5-Cl 2 12198 Me 2-NMe.sub.2, 5-Cl 2

12199 Me 2-NMe.sub.3OTf, 5-Cl 2 12200 Me 2-NMe.sub.3I, 5-Cl 2 12201 Me 2-Br, 4-F 2 12202 Me 2-Br, 4-NO.sub.2 2 12203 Me 2-Br, 4-NH.sub.2 2 12204 Me 2-Br, 4-NHMe 2 12205 Me 2-Br, 4-NMe.sub.2 2 12206 Me 2-Br, 4-NMe.sub.3OTf 2 12207 Me 2-Br, 4-NMe.sub.3I 2 12208 Me 2-Br, 5-F 2 12209 Me 2-Br, 5-NO.sub.2 2 12210 Me 2-Br, 5-NH.sub.2 2 12211 Me 2-Br, 5-NHMe 2 12212 Me 2-Br, 5-NMe.sub.2 2 12213 Me 2-Br, 5-NMe.sub.3OTf 2 12214 Me 2-Br, 5-NMe.sub.3I 2 12215 Me 2-F, 4-Br 2 12216 Me 2-NO.sub.2, 4-Br 2 12217 Me 2-NH.sub.2, 4-Br 2 12218 Me 2-NHMe, 4-Br 2 12219 Me 2-NMe.sub.2, 4-Br 2 12220 Me 2-NMe.sub.3OTf, 4-Br 2 12221 Me 2-NMe.sub.3I, 4-Br 2 12222 Me 2-I, 4-F 2 12223 Me 2-I, 4-NO.sub.2 2 12224 Me 2-I, 4-NH.sub.2 2 12225 Me 2-I, 4-NHMe 2 12226 Me 2-I, 4-NMe.sub.2 2 12227 Me 2-I, 4-NMe.sub.3OTf 2 12228 Me 2-I, 4-NMe.sub.3I 2 12229 Me 2-F, 4-I 2 12230 Me 2-NO.sub.2, 4-I 2 12231 Me 2-NH.sub.2, 4-I 2 12232 Me 2-NHMe, 4-I 2 12233 Me 2-NMe.sub.2, 4-I 2 12234 Me 2-NMe.sub.3OTf, 4-I 2 12235 Me 2-NMe.sub.3I, 4-I 2 12236 Me 2-Me, 3-F 2 12237 Me 2-Me, 3-NO.sub.2 2 12238 Me 2-Me, 3-NH.sub.2 2 12239 Me 2-Me, 3-NHMe 2 12240 Me 2-Me, 3-NMe.sub.2 2 12241 Me 2-Me, 3-NMe.sub.3OTf 2 12242 Me 2-Me, 3-NMe.sub.3I 2 12243 Me 2-Me, 4-F 2 12244 Me 2-Me, 4-NO.sub.2 2 12245 Me 2-Me, 4-NH.sub.2 2 12246 Me 2-Me, 4-NHMe 2 12247 Me 2-Me, 4-NMe.sub.2 2 12248 Me 2-Me, 4-NMe.sub.3OTf 2 12249 Me 2-Me, 4-NMe.sub.3I 2 12250 Me 2-Me, 5-F 2 12251 Me 2-Me, 5-NO.sub.2 2 12252 Me 2-Me, 5-NH.sub.2 2 12253 Me 2-Me, 5-NHMe 2 12254 Me 2-Me, 5-NMe.sub.2 2 12255 Me 2-Me, 5-NMe.sub.3OTf 2 12256 Me 2-Me, 5-NMe.sub.3I 2 12257 Me 2-F, 4-Me 2 12258 Me 2-NO.sub.2, 4-Me 2 12259 Me 2-NH.sub.2, 4-Me 2 12260 Me 2-NHMe, 4-Me 2 12261 Me 2-NMe.sub.2, 4-Me 2 12262 Me 2-NMe.sub.3, 4-Me 2 12263 Me 2-NMe.sub.3OTf, 4-Me 2 12264 Me 2-NMe.sub.3I, 4-Me 2 12265 Me 2-SnMe.sub.3, 4-F 2 12266 Me 2-SnMe.sub.3, 5-F 2 12267 Me 2-F, 4-SnMe.sub.3 2 12268 Me 2-Br, 6-Cl, 4-F 2 12269 Me 2-Br, 6-Cl, 4-NO.sub.2 2 12270 Me 2-Br, 6-Cl, 4-NH.sub.2 2 12271 Me 2-Br, 6-Cl, 4- 2 NHMe 12272 Me 2-Br, 6-Cl, 4-NMe.sub.2 2 12273 Me 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 12274 Me 2-Br, 6-Cl, 4- 2 NMe.sub.3I 12275 Me 2-Me, 6-Cl, 4-F 2 12276 Me 2-SnMe.sub.3, 6-Cl, 4-F 2 12277 Me 2-Cl, 4-Me 2 12278 Me 2-Cl, 4-Br 2 12279 Me 2-Cl, 4-SnMe.sub.3 2 12280 Me 2-Br, 4-Cl 2 12281 Me 2-SnMe.sub.3, 4-Cl 2 12282 Me 2-Me, 4-Cl 2 12283 Me 2-Br, 4-Br 2 12284 Me 2-Br, 4-Me 2 12285 Me 2-Br, 4-SnMe.sub.3 2 12286 Me 2-SnMe.sub.3, 4-Br 2 12287 Me 2-Me, 4-Br 2 12288 Me 2-Me, 4-SnMe.sub.3 2 12289 Me 2-SnMe.sub.3, 4-Me 2 12290 Me 2-Me, 4-Me 2 12291 Me 2-Et, 4-Br 2 12292 Me 2-Et, 4-SnMe.sub.3 2 12293 Me 2-Et, 4-Me 2 12294 Me 2-Me, 4-Me, 6-Me 2 12295 Me 2-Me, 4-Br, 6-Me 2 12296 Me 2-Me, 4-SnMe.sub.3, 6- 2 Me 12297 Me 2-Et, 6-Me 2 12298 Me 2-Br, 4-i-Pr 2 12299 Me 2-SnMe.sub.3, 4-i-Pr 2 12300 Me 2-Me, 4-i-Pr 2 12301 Me 2-Br, 4-Br, 6-Br 2 12302 Me 2-Br, 4-Me, 6-Br 2 12303 Me 2-Br, 4-SnMe.sub.3, 6- 2 Br 12304 Me 2-SnMe.sub.3, 4-Br, 6- 2 Br 12305 Me 2-Br, 4-Br, 6-Me 2 12306 Me 2-Br, 4-CF.sub.3, 6-Br 2 12307 Me 2-Br, 4-Br, 6-CF.sub.3 2 12308 Me 2-CF.sub.3, 4-CF.sub.3 2 12309 Me 2-Cl, 4-CF.sub.3 2 12310 Me 2-CF.sub.3, 4-Cl 2 12311 Me 2-Br, 4-CF.sub.3 2 12312 Me 2-SnMe.sub.3, 4-CF.sub.3 2 12313 Me 2-Me, 4-CF.sub.3 2 12314 Me 2-CF.sub.3, 4-Br 2 12315 Me 2-CF.sub.3, 4-SnMe.sub.3 2 12316 Me 2-CF.sub.3, 4-Me 2 12317 Me 2-Br, 4-OH 2 12318 Me 2-Br, 4-OMe 2 12319 Me 2-Br, 4-OMeF 2 12320 Me 2-Br, 4-OCF.sub.3 2 12321 Me 2-Br, 4-OEtF 2 12322 Me 2-Br, 4-OPrF 2 12323 Me 2-OH, 4-Br 2 12324 Me 2-OMe, 4-Br 2 12325 Me 2-OMeF, 4-Br 2 12326 Me 2-OCF.sub.3, 4-Br 2 12327 Me 2-OEtF, 4-Br 2 12328 Me 2-OPrF, 4-Br 2 12329 Me 2-I, 4-OH 2 12330 Me 2-I, 4-OMe 2 12331 Me 2-I, 4-OMeF 2 12332 Me 2-I, 4-OCF.sub.3 2 12333 Me 2-I, 4-OEtF 2 12334 Me 2-I, 4-OPrF 2 12335 Me 2-OH, 4-I 2 12336 Me 2-OMe, 4-I 2 12337 Me 2-OMeF, 4-I 2 12338 Me 2-OCF.sub.3, 4-I 2 12339 Me 2-OEtF, 4-I 2 12340 Me 2-OPrF, 4-I 2 12341 Me 2-SnMe.sub.3, 4-OH 2 12342 Me 2-SnMe.sub.3, 4-OMe 2 12343 Me 2-SnMe.sub.3, 4-OMeF 2 12344 Me 2-SnMe.sub.3, 4-OCF.sub.3 2 12345 Me 2-SnMe.sub.3, 4-OEtF 2 12346 Me 2-SnMe.sub.3, 4-OPrF 2 12347 Me 2-OH, 4-SnMe.sub.3 2 12348 Me 2-OMe, 4-SnMe.sub.3 2 12349 Me 2-OMeF, 4-SnMe.sub.3 2 12350 Me 2-OCF.sub.3, 4-SnMe.sub.3 2 12351 Me 2-OEtF, 4-SnMe.sub.3 2 12352 Me 2-OPrF, 4-SnMe.sub.3 2 12353 Me--F H 1 12354 Me--F 2-t-Bu 1 12355 Me--F 2-Br 1 12356 Me--F 3-Br 1 12357 Me--F 4-Br 1 12358 Me--F 2-I 1 12359 Me--F 3-I 1 12360 Me--F 4-I 1 12361 Me--F 2-SnMe.sub.3 1 12362 Me--F 3-SnMe.sub.3 1 12363 Me--F 4-SnMe.sub.3 1 12364 Me--F 2-Me 1 12365 Me--F 3-Me 1 12366 Me--F 4-Me 1 12367 Me--F 2-OH 1 12368 Me--F 3-OH 1 12369 Me--F 4-OH 1 12370 Me--F 2-OMe 1 12371 Me--F 3-OMe 1 12372 Me--F 4-OMe 1 12373 Me--F 2-OMeF 1 12374 Me--F 3-OMeF 1 12375 Me--F 4-OMeF 1 12376 Me--F 2-OCF.sub.3 1 12377 Me--F 3-OCF.sub.3 1 12378 Me--F 4-OCF.sub.3 1 12379 Me--F 2-OEtF 1 12380 Me--F 3-OEtF 1 12381 Me--F 4-OEtF 1 12382 Me--F 2-OPrF 1 12383 Me--F 3-OPrF 1 12384 Me--F 4-OPrF 1 12385 Me--F 2-SH 1 12386 Me--F 3-SH 1 12387 Me--F 4-SH 1 12388 Me--F 2-SMe 1 12389 Me--F 3-SMe 1 12390 Me--F 4-SMe 1 12391 Me--F 2-SMeF 1 12392 Me--F 3-SMeF 1 12393 Me--F 4-SMeF 1 12394 Me--F 2-SCF.sub.3 1 12395 Me--F 3-SCF.sub.3 1 12396 Me--F 4-SCF.sub.3 1 12397 Me--F 2-SEtF 1 12398 Me--F 3-SEtF 1 12399 Me--F 4-SEtF 1 12400 Me--F 2-SPrF 1 12401 Me--F 3-SPrF 1 12402 Me--F 4-SPrF 1 12403 Me--F 2-OMe, 4-OMe 1 12404 Me--F 2-Me, 5-OH 1 12405 Me--F 2-Me, 5-OMe 1 12406 Me--F 2-Me, 5-OMeF 1 12407 Me--F 2-Me, 5-OEtF 1 12408 Me--F 2-Me, 5-OPrF 1 12409 Me--F 2-Me, 4-OH 1 12410 Me--F 2-Me, 4-OMe 1 12411 Me--F 2-Me, 4-OMeF 1 12412 Me--F 2-Me, 4-OCF.sub.3 1 12413 Me--F 2-Me, 4-OEtF 1 12414 Me--F 2-Me, 4-OPrF 1 12415 Me--F 2-OH, 4-Me 1 12416 Me--F 2-OMe, 4-Me 1 12417 Me--F 2-OMeF, 4-Me 1 12418 Me--F 2-OCF.sub.3, 4-Me 1 12419 Me--F 2-OEtF, 4-Me 1 12420 Me--F 2-OPrF, 4-Me 1 12421 Me--F 2-Cl, 4-OH 1 12422 Me--F 2-Cl, 4-OMe 1 12423 Me--F 2-Cl, 4-OMeF 1 12424 Me--F 2-Cl, 4-OCF.sub.3 1 12425 Me--F 2-Cl, 4-OEtF 1 12426 Me--F 2-Cl, 4-OPrF 1 12427 Me--F 2-F, 4-F 1 12428 Me--F 2-Cl, 4-Cl 1 12429 Me--F 2-Cl, 4-F 1 12430 Me--F 2-Cl, 4-NO.sub.2 1 12431 Me--F 2-Cl, 4-NH.sub.2 1 12432 Me--F 2-Cl, 4-NHMe 1 12433 Me--F 2-Cl, 4-NMe.sub.2 1 12434 Me--F 2-Cl, 4-NMe.sub.3OTf 1 12435 Me--F 2-Cl, 4-NMe.sub.3I 1 12436 Me--F 2-Cl, 5-F 1 12437 Me--F 2-Cl, 5-NO.sub.2 1 12438 Me--F 2-Cl, 5-NH.sub.2 1 12439 Me--F 2-Cl, 5-NHMe 1 12440 Me--F 2-Cl, 5-NMe.sub.2 1 12441 Me--F 2-Cl, 5-NMe.sub.3OTf 1 12442 Me--F 2-Cl, 5-NMe.sub.3I 1 12443 Me--F 2-F, 4-Cl 1

12444 Me--F 2-NO.sub.2, 4-Cl 1 12445 Me--F 2-NH.sub.2, 4-Cl 1 12446 Me--F 2-NHMe, 4-Cl 1 12447 Me--F 2-NMe.sub.2, 4-Cl 1 12448 Me--F 2-NMe.sub.3OTf, 4-Cl 1 12449 Me--F 2-NMe.sub.3I, 4-Cl 1 12450 Me--F 2-F, 5-Cl 1 12451 Me--F 2-NO.sub.2, 5-Cl 1 12452 Me--F 2-NH.sub.2, 5-Cl 1 12453 Me--F 2-NHMe, 5-Cl 1 12454 Me--F 2-NMe.sub.2, 5-Cl 1 12455 Me--F 2-NMe.sub.3OTf, 5-Cl 1 12456 Me--F 2-NMe.sub.3I, 5-Cl 1 12457 Me--F 2-Br, 4-F 1 12458 Me--F 2-Br, 4-NO.sub.2 1 12459 Me--F 2-Br, 4-NH.sub.2 1 12460 Me--F 2-Br, 4-NHMe 1 12461 Me--F 2-Br, 4-NMe.sub.2 1 12462 Me--F 2-Br, 4-NMe.sub.3OTf 1 12463 Me--F 2-Br, 4-NMe.sub.3I 1 12464 Me--F 2-Br, 5-F 1 12465 Me--F 2-Br, 5-NO.sub.2 1 12466 Me--F 2-Br, 5-NH.sub.2 1 12467 Me--F 2-Br, 5-NHMe 1 12468 Me--F 2-Br, 5-NMe.sub.2 1 12469 Me--F 2-Br, 5-NMe.sub.3OTf 1 12470 Me--F 2-Br, 5-NMe.sub.3I 1 12471 Me--F 2-F, 4-Br 1 12472 Me--F 2-NO.sub.2, 4-Br 1 12473 Me--F 2-NH.sub.2, 4-Br 1 12474 Me--F 2-NHMe, 4-Br 1 12475 Me--F 2-NMe.sub.2, 4-Br 1 12476 Me--F 2-NMe.sub.3OTf, 4-Br 1 12477 Me--F 2-NMe.sub.3I, 4-Br 1 12478 Me--F 2-I, 4-F 1 12479 Me--F 2-I, 4-NO.sub.2 1 12480 Me--F 2-I, 4-NH.sub.2 1 12481 Me--F 2-I, 4-NHMe 1 12482 Me--F 2-I, 4-NMe.sub.2 1 12483 Me--F 2-I, 4-NMe.sub.3OTf 1 12484 Me--F 2-I, 4-NMe.sub.3I 1 12485 Me--F 2-F, 4-I 1 12486 Me--F 2-NO.sub.2, 4-I 1 12487 Me--F 2-NH.sub.2, 4-I 1 12488 Me--F 2-NHMe, 4-I 1 12489 Me--F 2-NMe.sub.2, 4-I 1 12490 Me--F 2-NMe.sub.3OTf, 4-I 1 12491 Me--F 2-NMe.sub.3I, 4-I 1 12492 Me--F 2-Me, 3-F 1 12493 Me--F 2-Me, 3-NO.sub.2 1 12494 Me--F 2-Me, 3-NH.sub.2 1 12495 Me--F 2-Me, 3-NHMe 1 12496 Me--F 2-Me, 3-NMe.sub.2 1 12497 Me--F 2-Me, 3-NMe.sub.3OTf 1 12498 Me--F 2-Me, 3-NMe.sub.3I 1 12499 Me--F 2-Me, 4-F 1 12500 Me--F 2-Me, 4-NO.sub.2 1 12501 Me--F 2-Me, 4-NH.sub.2 1 12502 Me--F 2-Me, 4-NHMe 1 12503 Me--F 2-Me, 4-NMe.sub.2 1 12504 Me--F 2-Me, 4-NMe.sub.3OTf 1 12505 Me--F 2-Me, 4-NMe.sub.3I 1 12506 Me--F 2-Me, 5-F 1 12507 Me--F 2-Me, 5-NO.sub.2 1 12508 Me--F 2-Me, 5-NH.sub.2 1 12509 Me--F 2-Me, 5-NHMe 1 12510 Me--F 2-Me, 5-NMe.sub.2 1 12511 Me--F 2-Me, 5-NMe.sub.3OTf 1 12512 Me--F 2-Me, 5-NMe.sub.3I 1 12513 Me--F 2-F, 4-Me 1 12514 Me--F 2-NO.sub.2, 4-Me 1 12515 Me--F 2-NH.sub.2, 4-Me 1 12516 Me--F 2-NHMe, 4-Me 1 12517 Me--F 2-NMe.sub.2, 4-Me 1 12518 Me--F 2-NMe.sub.3, 4-Me 1 12519 Me--F 2-NMe.sub.3OTf, 4-Me 1 12520 Me--F 2-NMe.sub.3I, 4-Me 1 12521 Me--F 2-SnMe.sub.3, 4-F 1 12522 Me--F 2-SnMe.sub.3, 5-F 1 12523 Me--F 2-F, 4-SnMe.sub.3 1 12524 Me--F 2-Br, 6-Cl, 4-F 1 12525 Me--F 2-Br, 6-Cl, 4-NO.sub.2 1 12526 Me--F 2-Br, 6-Cl, 4-NH.sub.2 1 12527 Me--F 2-Br, 6-Cl, 4- 1 NHMe 12528 Me--F 2-Br, 6-Cl, 4-NMe.sub.2 1 12529 Me--F 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 12530 Me--F 2-Br, 6-Cl, 4- 1 NMe.sub.3I 12531 Me--F 2-Me, 6-Cl, 4-F 1 12532 Me--F 2-SnMe.sub.3, 6-Cl, 4-F 1 12533 Me--F 2-Cl, 4-Me 1 12534 Me--F 2-Cl, 4-Br 1 12535 Me--F 2-Cl, 4-SnMe.sub.3 1 12536 Me--F 2-Br, 4-Cl 1 12537 Me--F 2-SnMe.sub.3, 4-Cl 1 12538 Me--F 2-Me, 4-Cl 1 12539 Me--F 2-Br, 4-Br 1 12540 Me--F 2-Br, 4-Me 1 12541 Me--F 2-Br, 4-SnMe.sub.3 1 12542 Me--F 2-SnMe.sub.3, 4-Br 1 12543 Me--F 2-Me, 4-Br 1 12544 Me--F 2-Me, 4-SnMe.sub.3 1 12545 Me--F 2-SnMe.sub.3, 4-Me 1 12546 Me--F 2-Me, 4-Me 1 12547 Me--F 2-Et, 4-Br 1 12548 Me--F 2-Et, 4-SnMe.sub.3 1 12549 Me--F 2-Et, 4-Me 1 12550 Me--F 2-Me, 4-Me, 6-Me 1 12551 Me--F 2-Me, 4-Br, 6-Me 1 12552 Me--F 2-Me, 4-SnMe.sub.3, 6- 1 Me 12553 Me--F 2-Et, 6-Me 1 12554 Me--F 2-Br, 4-i-Pr 1 12555 Me--F 2-SnMe.sub.3, 4-i-Pr 1 12556 Me--F 2-Me, 4-i-Pr 1 12557 Me--F 2-Br, 4-Br, 6-Br 1 12558 Me--F 2-Br, 4-Me, 6-Br 1 12559 Me--F 2-Br, 4-SnMe.sub.3, 6- 1 Br 12560 Me--F 2-SnMe.sub.3, 4-Br, 6- 1 Br 12561 Me--F 2-Br, 4-Br, 6-Me 1 12562 Me--F 2-Br, 4-CF.sub.3, 6-Br 1 12563 Me--F 2-Br, 4-Br, 6-CF.sub.3 1 12564 Me--F 2-CF.sub.3, 4-CF.sub.3 1 12565 Me--F 2-Cl, 4-CF.sub.3 1 12566 Me--F 2-CF.sub.3, 4-Cl 1 12567 Me--F 2-Br, 4-CF.sub.3 1 12568 Me--F 2-SnMe.sub.3, 4-CF.sub.3 1 12569 Me--F 2-Me, 4-CF.sub.3 1 12570 Me--F 2-CF.sub.3, 4-Br 1 12571 Me--F 2-CF.sub.3, 4-SnMe.sub.3 1 12572 Me--F 2-CF.sub.3, 4-Me 1 12573 Me--F 2-Br, 4-OH 1 12574 Me--F 2-Br, 4-OMe 1 12575 Me--F 2-Br, 4-OMeF 1 12576 Me--F 2-Br, 4-OCF.sub.3 1 12577 Me--F 2-Br, 4-OEtF 1 12578 Me--F 2-Br, 4-OPrF 1 12579 Me--F 2-OH, 4-Br 1 12580 Me--F 2-OMe, 4-Br 1 12581 Me--F 2-OMeF, 4-Br 1 12582 Me--F 2-OCF.sub.3, 4-Br 1 12583 Me--F 2-OEtF, 4-Br 1 12584 Me--F 2-OPrF, 4-Br 1 12585 Me--F 2-I, 4-OH 1 12586 Me--F 2-I, 4-OMe 1 12587 Me--F 2-I, 4-OMeF 1 12588 Me--F 2-I, 4-OCF.sub.3 1 12589 Me--F 2-I, 4-OEtF 1 12590 Me--F 2-I, 4-OPrF 1 12591 Me--F 2-OH, 4-I 1 12592 Me--F 2-OMe, 4-I 1 12593 Me--F 2-OMeF, 4-I 1 12594 Me--F 2-OCF.sub.3, 4-I 1 12595 Me--F 2-OEtF, 4-I 1 12596 Me--F 2-OPrF, 4-I 1 12597 Me--F 2-SnMe.sub.3, 4-OH 1 12598 Me--F 2-SnMe.sub.3, 4-OMe 1 12599 Me--F 2-SnMe.sub.3, 4-OMeF 1 12600 Me--F 2-SnMe.sub.3, 4-OCF.sub.3 1 12601 Me--F 2-SnMe.sub.3, 4-OEtF 1 12602 Me--F 2-SnMe.sub.3, 4-OPrF 1 12603 Me--F 2-OH, 4-SnMe.sub.3 1 12604 Me--F 2-OMe, 4-SnMe.sub.3 1 12605 Me--F 2-OMeF, 4-SnMe.sub.3 1 12606 Me--F 2-OCF.sub.3, 4-SnMe.sub.3 1 12607 Me--F 2-OEtF, 4-SnMe.sub.3 1 12608 Me--F 2-OPrF, 4-SnMe.sub.3 1 12609 Me--F H 2 12610 Me--F 2-t-Bu 2 12611 Me--F 2-Br 2 12612 Me--F 3-Br 2 12613 Me--F 4-Br 2 12614 Me--F 2-I 2 12615 Me--F 3-I 2 12616 Me--F 4-I 2 12617 Me--F 2-SnMe.sub.3 2 12618 Me--F 3-SnMe.sub.3 2 12619 Me--F 4-SnMe.sub.3 2 12620 Me--F 2-Me 2 12621 Me--F 3-Me 2 12622 Me--F 4-Me 2 12623 Me--F 2-OH 2 12624 Me--F 3-OH 2 12625 Me--F 4-OH 2 12626 Me--F 2-OMe 2 12627 Me--F 3-OMe 2 12628 Me--F 4-OMe 2 12629 Me--F 2-OMeF 2 12630 Me--F 3-OMeF 2 12631 Me--F 4-OMeF 2 12632 Me--F 2-OCF.sub.3 2 12633 Me--F 3-OCF.sub.3 2 12634 Me--F 4-OCF.sub.3 2 12635 Me--F 2-OEtF 2 12636 Me--F 3-OEtF 2 12637 Me--F 4-OEtF 2 12638 Me--F 2-OPrF 2 12639 Me--F 3-OPrF 2 12640 Me--F 4-OPrF 2 12641 Me--F 2-SH 2 12642 Me--F 3-SH 2 12643 Me--F 4-SH 2 12644 Me--F 2-SMe 2 12645 Me--F 3-SMe 2 12646 Me--F 4-SMe 2 12647 Me--F 2-SMeF 2 12648 Me--F 3-SMeF 2 12649 Me--F 4-SMeF 2 12650 Me--F 2-SCF.sub.3 2 12651 Me--F 3-SCF.sub.3 2 12652 Me--F 4-SCF.sub.3 2 12653 Me--F 2-SEtF 2 12654 Me--F 3-SEtF 2 12655 Me--F 4-SEtF 2 12656 Me--F 2-SPrF 2 12657 Me--F 3-SPrF 2 12658 Me--F 4-SPrF 2 12659 Me--F 2-OMe, 4-OMe 2 12660 Me--F 2-Me, 5-OH 2 12661 Me--F 2-Me, 5-OMe 2 12662 Me--F 2-Me, 5-OMeF 2 12663 Me--F 2-Me, 5-OEtF 2 12664 Me--F 2-Me, 5-OPrF 2 12665 Me--F 2-Me, 4-OH 2 12666 Me--F 2-Me, 4-OMe 2 12667 Me--F 2-Me, 4-OMeF 2 12668 Me--F 2-Me, 4-OCF.sub.3 2 12669 Me--F 2-Me, 4-OEtF 2 12670 Me--F 2-Me, 4-OPrF 2 12671 Me--F 2-OH, 4-Me 2 12672 Me--F 2-OMe, 4-Me 2 12673 Me--F 2-OMeF, 4-Me 2 12674 Me--F 2-OCF.sub.3, 4-Me 2 12675 Me--F 2-OEtF, 4-Me 2 12676 Me--F 2-OPrF, 4-Me 2 12677 Me--F 2-Cl, 4-OH 2 12678 Me--F 2-Cl, 4-OMe 2 12679 Me--F 2-Cl, 4-OMeF 2 12680 Me--F 2-Cl, 4-OCF.sub.3 2 12681 Me--F 2-Cl, 4-OEtF 2 12682 Me--F 2-Cl, 4-OPrF 2 12683 Me--F 2-F, 4-F 2 12684 Me--F 2-Cl, 4-Cl 2 12685 Me--F 2-Cl, 4-F 2 12686 Me--F 2-Cl, 4-NO.sub.2 2 12687 Me--F 2-Cl, 4-NH.sub.2 2 12688 Me--F 2-Cl, 4-NHMe 2

12689 Me--F 2-Cl, 4-NMe.sub.2 2 12690 Me--F 2-Cl, 4-NMe.sub.3OTf 2 12691 Me--F 2-Cl, 4-NMe.sub.3I 2 12692 Me--F 2-Cl, 5-F 2 12693 Me--F 2-Cl, 5-NO.sub.2 2 12694 Me--F 2-Cl, 5-NH.sub.2 2 12695 Me--F 2-Cl, 5-NHMe 2 12696 Me--F 2-Cl, 5-NMe.sub.2 2 12697 Me--F 2-Cl, 5-NMe.sub.3OTf 2 12698 Me--F 2-Cl, 5-NMe.sub.3I 2 12699 Me--F 2-F, 4-Cl 2 12700 Me--F 2-NO.sub.2, 4-Cl 2 12701 Me--F 2-NH.sub.2, 4-Cl 2 12702 Me--F 2-NHMe, 4-Cl 2 12703 Me--F 2-NMe.sub.2, 4-Cl 2 12704 Me--F 2-NMe.sub.3OTf, 4-Cl 2 12705 Me--F 2-NMe.sub.3I, 4-Cl 2 12706 Me--F 2-F, 5-Cl 2 12707 Me--F 2-NO.sub.2, 5-Cl 2 12708 Me--F 2-NH.sub.2, 5-Cl 2 12709 Me--F 2-NHMe, 5-Cl 2 12710 Me--F 2-NMe.sub.2, 5-Cl 2 12711 Me--F 2-NMe.sub.3OTf, 5-Cl 2 12712 Me--F 2-NMe.sub.3I, 5-Cl 2 12713 Me--F 2-Br, 4-F 2 12714 Me--F 2-Br, 4-NO.sub.2 2 12715 Me--F 2-Br, 4-NH.sub.2 2 12716 Me--F 2-Br, 4-NHMe 2 12717 Me--F 2-Br, 4-NMe.sub.2 2 12718 Me--F 2-Br, 4-NMe.sub.3OTf 2 12719 Me--F 2-Br, 4-NMe.sub.3I 2 12720 Me--F 2-Br, 5-F 2 12721 Me--F 2-Br, 5-NO.sub.2 2 12722 Me--F 2-Br, 5-NH.sub.2 2 12723 Me--F 2-Br, 5-NHMe 2 12724 Me--F 2-Br, 5-NMe.sub.2 2 12725 Me--F 2-Br, 5-NMe.sub.3OTf 2 12726 Me--F 2-Br, 5-NMe.sub.3I 2 12727 Me--F 2-F, 4-Br 2 12728 Me--F 2-NO.sub.2, 4-Br 2 12729 Me--F 2-NH.sub.2, 4-Br 2 12730 Me--F 2-NHMe, 4-Br 2 12731 Me--F 2-NMe.sub.2, 4-Br 2 12732 Me--F 2-NMe.sub.3OTf, 4-Br 2 12733 Me--F 2-NMe.sub.3I, 4-Br 2 12734 Me--F 2-I, 4-F 2 12735 Me--F 2-I, 4-NO.sub.2 2 12736 Me--F 2-I, 4-NH.sub.2 2 12737 Me--F 2-I, 4-NHMe 2 12738 Me--F 2-I, 4-NMe.sub.2 2 12739 Me--F 2-I, 4-NMe.sub.3OTf 2 12740 Me--F 2-I, 4-NMe.sub.3I 2 12741 Me--F 2-F, 4-I 2 12742 Me--F 2-NO.sub.2, 4-I 2 12743 Me--F 2-NH.sub.2, 4-I 2 12744 Me--F 2-NHMe, 4-I 2 12745 Me--F 2-NMe.sub.2, 4-I 2 12746 Me--F 2-NMe.sub.3OTf, 4-I 2 12747 Me--F 2-NMe.sub.3I, 4-I 2 12748 Me--F 2-Me, 3-F 2 12749 Me--F 2-Me, 3-NO.sub.2 2 12750 Me--F 2-Me, 3-NH.sub.2 2 12751 Me--F 2-Me, 3-NHMe 2 12752 Me--F 2-Me, 3-NMe.sub.2 2 12753 Me--F 2-Me, 3-NMe.sub.3OTf 2 12754 Me--F 2-Me, 3-NMe.sub.3I 2 12755 Me--F 2-Me, 4-F 2 12756 Me--F 2-Me, 4-NO.sub.2 2 12757 Me--F 2-Me, 4-NH.sub.2 2 12758 Me--F 2-Me, 4-NHMe 2 12759 Me--F 2-Me, 4-NMe.sub.2 2 12760 Me--F 2-Me, 4-NMe.sub.3OTf 2 12761 Me--F 2-Me, 4-NMe.sub.3I 2 12762 Me--F 2-Me, 5-F 2 12763 Me--F 2-Me, 5-NO.sub.2 2 12764 Me--F 2-Me, 5-NH.sub.2 2 12765 Me--F 2-Me, 5-NHMe 2 12766 Me--F 2-Me, 5-NMe.sub.2 2 12767 Me--F 2-Me, 5-NMe.sub.3OTf 2 12768 Me--F 2-Me, 5-NMe.sub.3I 2 12769 Me--F 2-F, 4-Me 2 12770 Me--F 2-NO.sub.2, 4-Me 2 12771 Me--F 2-NH.sub.2, 4-Me 2 12772 Me--F 2-NHMe, 4-Me 2 12773 Me--F 2-NMe.sub.2, 4-Me 2 12774 Me--F 2-NMe.sub.3, 4-Me 2 12775 Me--F 2-NMe.sub.3OTf, 4-Me 2 12776 Me--F 2-NMe.sub.3I, 4-Me 2 12777 Me--F 2-SnMe.sub.3, 4-F 2 12778 Me--F 2-SnMe.sub.3, 5-F 2 12779 Me--F 2-F, 4-SnMe.sub.3 2 12780 Me--F 2-Br, 6-Cl, 4-F 2 12781 Me--F 2-Br, 6-Cl, 4-NO.sub.2 2 12782 Me--F 2-Br, 6-Cl, 4-NH.sub.2 2 12783 Me--F 2-Br, 6-Cl, 4- 2 NHMe 12784 Me--F 2-Br, 6-Cl, 4-NMe.sub.2 2 12785 Me--F 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 12786 Me--F 2-Br, 6-Cl, 4- 2 NMe.sub.3I 12787 Me--F 2-Me, 6-Cl, 4-F 2 12788 Me--F 2-SnMe.sub.3, 6-Cl, 4-F 2 12789 Me--F 2-Cl, 4-Me 2 12790 Me--F 2-Cl, 4-Br 2 12791 Me--F 2-Cl, 4-SnMe.sub.3 2 12792 Me--F 2-Br, 4-Cl 2 12793 Me--F 2-SnMe.sub.3, 4-Cl 2 12794 Me--F 2-Me, 4-Cl 2 12795 Me--F 2-Br, 4-Br 2 12796 Me--F 2-Br, 4-Me 2 12797 Me--F 2-Br, 4-SnMe.sub.3 2 12798 Me--F 2-SnMe.sub.3, 4-Br 2 12799 Me--F 2-Me, 4-Br 2 12800 Me--F 2-Me, 4-SnMe.sub.3 2 12801 Me--F 2-SnMe.sub.3, 4-Me 2 12802 Me--F 2-Me, 4-Me 2 12803 Me--F 2-Et, 4-Br 2 12804 Me--F 2-Et, 4-SnMe.sub.3 2 12805 Me--F 2-Et, 4-Me 2 12806 Me--F 2-Me, 4-Me, 6-Me 2 12807 Me--F 2-Me, 4-Br, 6-Me 2 12808 Me--F 2-Me, 4-SnMe.sub.3, 6- 2 Me 12809 Me--F 2-Et, 6-Me 2 12810 Me--F 2-Br, 4-i-Pr 2 12811 Me--F 2-SnMe.sub.3, 4-i-Pr 2 12812 Me--F 2-Me, 4-i-Pr 2 12813 Me--F 2-Br, 4-Br, 6-Br 2 12814 Me--F 2-Br, 4-Me, 6-Br 2 12815 Me--F 2-Br, 4-SnMe.sub.3, 6- 2 Br 12816 Me--F 2-SnMe.sub.3, 4-Br, 6- 2 Br 12817 Me--F 2-Br, 4-Br, 6-Me 2 12818 Me--F 2-Br, 4-CF.sub.3, 6-Br 2 12819 Me--F 2-Br, 4-Br, 6-CF.sub.3 2 12820 Me--F 2-CF.sub.3, 4-CF.sub.3 2 12821 Me--F 2-Cl, 4-CF.sub.3 2 12822 Me--F 2-CF.sub.3, 4-Cl 2 12823 Me--F 2-Br, 4-CF.sub.3 2 12824 Me--F 2-SnMe.sub.3, 4-CF.sub.3 2 12825 Me--F 2-Me, 4-CF.sub.3 2 12826 Me--F 2-CF.sub.3, 4-Br 2 12827 Me--F 2-CF.sub.3, 4-SnMe.sub.3 2 12828 Me--F 2-CF.sub.3, 4-Me 2 12829 Me--F 2-Br, 4-OH 2 12830 Me--F 2-Br, 4-OMe 2 12831 Me--F 2-Br, 4-OMeF 2 12832 Me--F 2-Br, 4-OCF.sub.3 2 12833 Me--F 2-Br, 4-OEtF 2 12834 Me--F 2-Br, 4-OPrF 2 12835 Me--F 2-OH, 4-Br 2 12836 Me--F 2-OMe, 4-Br 2 12837 Me--F 2-OMeF, 4-Br 2 12838 Me--F 2-OCF.sub.3, 4-Br 2 12839 Me--F 2-OEtF, 4-Br 2 12840 Me--F 2-OPrF, 4-Br 2 12841 Me--F 2-I, 4-OH 2 12842 Me--F 2-I, 4-OMe 2 12843 Me--F 2-I, 4-OMeF 2 12844 Me--F 2-I, 4-OCF.sub.3 2 12845 Me--F 2-I, 4-OEtF 2 12846 Me--F 2-I, 4-OPrF 2 12847 Me--F 2-OH, 4-I 2 12848 Me--F 2-OMe, 4-I 2 12849 Me--F 2-OMeF, 4-I 2 12850 Me--F 2-OCF.sub.3, 4-I 2 12851 Me--F 2-OEtF, 4-I 2 12852 Me--F 2-OPrF, 4-I 2 12853 Me--F 2-SnMe.sub.3, 4-OH 2 12854 Me--F 2-SnMe.sub.3, 4-OMe 2 12855 Me--F 2-SnMe.sub.3, 4-OMeF 2 12856 Me--F 2-SnMe.sub.3, 4-OCF.sub.3 2 12857 Me--F 2-SnMe.sub.3, 4-OEtF 2 12858 Me--F 2-SnMe.sub.3, 4-OPrF 2 12859 Me--F 2-OH, 4-SnMe.sub.3 2 12860 Me--F 2-OMe, 4-SnMe.sub.3 2 12861 Me--F 2-OMeF, 4-SnMe.sub.3 2 12862 Me--F 2-OCF.sub.3, 4-SnMe.sub.3 2 12863 Me--F 2-OEtF, 4-SnMe.sub.3 2 12864 Me--F 2-OPrF, 4-SnMe.sub.3 2 12865 FCH.sub.2--CH.dbd.CH--CH.sub.2 H 1 12866 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-t-Bu 1 12867 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br 1 12868 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Br 1 12869 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Br 1 12870 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I 1 12871 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-I 1 12872 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-I 1 12873 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3 1 12874 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SnMe.sub.3 1 12875 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SnMe.sub.3 1 12876 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me 1 12877 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Me 1 12878 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Me 1 12879 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH 1 12880 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OH 1 12881 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OH 1 12882 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe 1 12883 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMe 1 12884 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMe 1 12885 FCH.sub.2--CH--CH--CH.sub.2 2-OMeF 1 12886 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMeF 1 12887 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMeF 1 12888 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3 1 12889 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OCF.sub.3 1 12890 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OCF.sub.3 1 12891 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF 1 12892 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OEtF 1 12893 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OEtF 1 12894 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF 1 12895 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OPrF 1 12896 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OPrF 1 12897 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SH 1 12898 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SH 1 12899 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SH 1 12900 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMe 1 12901 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMe 1 12902 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMe 1 12903 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMeF 1 12904 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMeF 1 12905 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMeF 1 12906 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SCF.sub.3 1 12907 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SCF.sub.3 1 12908 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SCF.sub.3 1 12909 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SEtF 1 12910 I,CH.sub.2--CH.dbd.CH--CH.sub.2 3-SEtF 1 12911 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SEtF 1 12912 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SPrF 1 12913 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SPrF 1 12914 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SPrF 1 12915 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-OMe 1 12916 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OH 1 12917 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMe 1 12918 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMeF 1 12919 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OEtF 1 12920 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OPrF 1 12921 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OH 1 12922 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMe 1 12923 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMeF 1 12924 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OCF.sub.3 1 12925 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OEtF 1 12926 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OPrF 1 12927 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Me 1 12928 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-Me 1 12929 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Me 1 12930 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Me 1 12931 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Me 1 12932 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Me 1 12933 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OH 1

12934 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMe 1 12935 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMeF 1 12936 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OCF.sub.3 1 12937 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OEtF 1 12938 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OPrF 1 12939 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-F 1 12940 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Cl 1 12941 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-F 1 12942 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NO.sub.2 1 12943 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NH.sub.2 1 12944 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NHMe 1 12945 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.2 1 12946 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3OTf 1 12947 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3I 1 12948 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-F 1 12949 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NO.sub.2 1 12950 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NH.sub.2 1 12951 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NHMe 1 12952 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.2 1 12953 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.3OTf 1 12954 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.3I 1 12955 FCH.sub.2--CH--CH--CH.sub.2 2-F, 4-Cl 1 12956 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Cl 1 12957 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Cl 1 12958 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Cl 1 12959 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Cl 1 12960 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Cl 1 12961 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Cl 1 12962 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 5-Cl 1 12963 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 5-Cl 1 12964 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 5-Cl 1 12965 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 5-Cl 1 12966 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 5-Cl 1 12967 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 5-Cl 1 12968 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 5-Cl 1 12969 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-F 1 12970 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NO.sub.2 1 12971 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NH.sub.2 1 12972 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NHMe 1 12973 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.2 1 12974 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.3OTf 1 12975 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.3I 1 12976 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-F 1 12977 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NO.sub.2 1 12978 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NH.sub.2 1 12979 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NHMe 1 12980 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.2 1 12981 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.3OTf 1 12982 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.3I 1 12983 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Br 1 12984 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Br 1 12985 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Br 1 12986 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Br 1 12987 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Br 1 12988 FCH.sub.2--CH--CH--CH.sub.2 2-NMe.sub.3OTf, 4-Br 1 12989 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Br 1 12990 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-F 1 12991 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NO.sub.2 1 12992 FCH.sub.2--CH--CH--CH.sub.2 2-I, 4-NH.sub.2 1 12993 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NHMe 1 12994 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.2 1 12995 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3OTf 1 12996 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3I 1 12997 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-I 1 12998 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-I 1 12999 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-I 1 13000 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-I 1 13001 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-I 1 13002 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-I 1 13003 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-I 1 13004 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-F 1 13005 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NO.sub.2 1 13006 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NH.sub.2 1 13007 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NHMe 1 13008 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.2 1 13009 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3OTf 1 13010 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3I 1 13011 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-F 1 13012 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NO.sub.2 1 13013 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NH.sub.2 1 13014 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NHMe 1 13015 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.2 1 13016 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3OTf 1 13017 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3I 1 13018 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-F 1 13019 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NO.sub.2 1 13020 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NH.sub.2 1 13021 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NHMe 1 13022 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.2 1 13023 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3OTf 1 13024 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3I 1 13025 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Me 1 13026 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Me 1 13027 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Me 1 13028 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Me 1 13029 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Me 1 13030 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3, 4-Me 1 13031 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Me 1 13032 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Me 1 13033 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-F 1 13034 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 5-F 1 13035 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-SnMe.sub.3 1 13036 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-F 1 13037 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NO.sub.2 1 13038 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NH.sub.2 1 13039 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4- 1 NHMe 13040 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NMe.sub.2 1 13041 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 13042 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4- 1 NMe.sub.3I 13043 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 6-Cl, 4-F 1 13044 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 6-Cl, 4-F 1 13045 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Me 1 13046 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Br 1 13047 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-SnMe.sub.3 1 13048 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Cl 1 13049 FCH.sub.2--CH--CH--CH.sub.2 2-SnMe.sub.3, 4-Cl 1 13050 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Cl 1 13051 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br 1 13052 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Me 1 13053 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3 1 13054 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br 1 13055 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br 1 13056 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3 1 13057 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Me 1 13058 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me 1 13059 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Br 1 13060 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-SnMe.sub.3 1 13061 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Me 1 13062 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me, 6-Me 1 13063 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br, 6-Me 1 13064 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3, 6- 1 Me 13065 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 6-Me 1 13066 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-i-Pr 1 13067 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-i-Pr 1 13068 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-i-Pr 1 13069 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Br 1 13070 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Me, 6-Br 1 13071 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3, 6- 1 Br 13072 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br, 6- 1 Br 13073 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Me 1 13074 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3, 6-Br 1 13075 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-CF.sub.3 1 13076 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-CF.sub.3 1 13077 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-CF.sub.3 1 13078 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Cl 1 13079 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3 1 13080 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-CF.sub.3 1 13081 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-CF.sub.3 1 13082 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Br 1 13083 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-SnMe.sub.3 1 13084 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Me 1 13085 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OH 1 13086 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMe 1 13087 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMeF 1 13088 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OCF.sub.3 1 13089 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OEtF 1 13090 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OPrF 1 13091 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Br 1 13092 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-Br 1 13093 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Br 1 13094 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Br 1 13095 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Br 1 13096 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Br 1 13097 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OH 1 13098 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMe 1 13099 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMeF 1 13100 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OCF.sub.3 1 13101 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OEtF 1 13102 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OPrF 1 13103 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-I 1 13104 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-I 1 13105 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-I 1 13106 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-I 1 13107 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-I 1 13108 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-I 1 13109 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OH 1 13110 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMe 1 13111 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMeF 1 13112 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OCF.sub.3 1 13113 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OEtF 1 13114 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OPrF 1 13115 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-SnMe.sub.3 1 13116 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-SnMe.sub.3 1 13117 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-SnMe.sub.3 1 13118 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-SnMe.sub.3 1 13119 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-SnMe.sub.3 1 13120 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-SnMe.sub.3 1 13121 FCH.sub.2--CH.dbd.CH--CH.sub.2 H 2 13122 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-t-Bu 2 13123 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br 2 13124 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Br 2 13125 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Br 2 13126 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I 2 13127 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-I 2 13128 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-I 2 13129 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3 2 13130 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SnMe.sub.3 2 13131 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SnMe.sub.3 2 13132 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me 2 13133 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Me 2 13134 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Me 2 13135 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH 2 13136 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OH 2 13137 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OH 2 13138 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe 2 13139 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMe 2 13140 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMe 2 13141 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF 2 13142 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMeF 2 13143 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMeF 2 13144 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3 2 13145 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OCF.sub.3 2 13146 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OCF.sub.3 2 13147 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF 2 13148 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OEtF 2 13149 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OEtF 2 13150 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF 2 13151 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OPrF 2 13152 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OPrF 2 13153 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SH 2 13154 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SH 2 13155 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SH 2 13156 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMe 2 13157 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMe 2 13158 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMe 2 13159 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMeF 2 13160 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMeF 2 13161 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMeF 2 13162 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SCF.sub.3 2 13163 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SCF.sub.3 2 13164 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SCF.sub.3 2 13165 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SEtF 2 13166 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SEtF 2 13167 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SEtF 2 13168 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SPrF 2 13169 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SPrF 2 13170 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SPrF 2 13171 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-OMe 2 13172 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OH 2 13173 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMe 2 13174 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMeF 2 13175 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OEtF 2 13176 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OPrF 2 13177 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OH 2 13178 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMe 2

13179 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMeF 2 13180 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OCF.sub.3 2 13181 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OEtF 2 13182 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OPrF 2 13183 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Me 2 13184 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-Me 2 13185 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Me 2 13186 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Me 2 13187 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Me 2 13188 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Me 2 13189 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OH 2 13190 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMe 2 13191 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMeF 2 13192 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OCF.sub.3 2 13193 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OEtF 2 13194 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OPrF 2 13195 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-F 2 13196 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Cl 2 13197 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-F 2 13198 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NO.sub.2 2 13199 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NH.sub.2 2 13200 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NHMe 2 13201 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.2 2 13202 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3OTf 2 13203 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3I 2 13204 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-F 2 13205 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NO.sub.2 2 13206 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NH.sub.2 2 13207 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NHMe 2 13208 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.2 2 13209 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.3OTf 2 13210 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.3I 2 13211 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Cl 2 13212 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Cl 2 13213 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Cl 2 13214 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Cl 2 13215 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Cl 2 13216 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Cl 2 13217 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Cl 2 13218 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 5-Cl 2 13219 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 5-Cl 2 13220 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 5-Cl 2 13221 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 5-Cl 2 13222 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 5-Cl 2 13223 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 5-Cl 2 13224 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 5-Cl 2 13225 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-F 2 13226 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NO.sub.2 2 13227 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NH.sub.2 2 13228 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NHMe 2 13229 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.2 2 13230 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.3OTf 2 13231 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.3I 2 13232 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-F 2 13233 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NO.sub.2 2 13234 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NH.sub.2 2 13235 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NHMe 2 13236 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.2 2 13237 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.3OTf 2 13238 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.3I 2 13239 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Br 2 13240 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Br 2 13241 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Br 2 13242 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Br 2 13243 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Br 2 13244 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Br 2 13245 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Br 2 13246 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-F 2 13247 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NO.sub.2 2 13248 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NH.sub.2 2 13249 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NHMe 2 13250 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.2 2 13251 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3OTf 2 13252 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3I 2 13253 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-I 2 13254 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-I 2 13255 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-I 2 13256 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-I 2 13257 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-I 2 13258 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-I 2 13259 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-I 2 13260 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-F 2 13261 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NO.sub.2 2 13262 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NH.sub.2 2 13263 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NHMe 2 13264 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.2 2 13265 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3OTf 2 13266 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3I 2 13267 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-F 2 13268 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NO.sub.2 2 13269 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NH.sub.2 2 13270 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NHMe 2 13271 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.2 2 13272 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3OTf 2 13273 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3I 2 13274 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-F 2 13275 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NO.sub.2 2 13276 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NH.sub.2 2 13277 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NHMe 2 13278 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.2 2 13279 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3OTf 2 13280 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3I 2 13281 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Me 2 13282 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Me 2 13283 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Me 2 13284 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Me 2 13285 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Me 2 13286 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3, 4-Me 2 13287 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Me 2 13288 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Me 2 13289 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-F 2 13290 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 5-F 2 13291 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-SnMe.sub.3 2 13292 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-F 2 13293 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NO.sub.2 2 13294 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NH.sub.2 2 13295 FCH.sub.2--CH--CH--CH.sub.2 2-Br, 6-Cl, 4- 2 NHMe 13296 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NMe.sub.2 2 13297 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 13298 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4- 2 NMe.sub.3I 13299 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 6-Cl, 4-F 2 13300 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 6-Cl, 4-F 2 13301 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Me 2 13302 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Br 2 13303 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-SnMe.sub.3 2 13304 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Cl 2 13305 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Cl 2 13306 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Cl 2 13307 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br 2 13308 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Me 2 13309 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3 2 13310 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br 2 13311 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br 2 13312 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3 2 13313 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Me 2 13314 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me 2 13315 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Br 2 13316 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-SnMe.sub.3 2 13317 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Me 2 13318 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me, 6-Me 2 13319 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br, 6-Me 2 13320 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3, 6- 2 Me 13321 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 6-Me 2 13322 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-i-Pr 2 13323 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-i-Pr 2 13324 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-i-Pr 2 13325 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Br 2 13326 FCH.sub.2--CH--CH--CH.sub.2 2-Br, 4-Me, 6-Br 2 13327 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3, 6- 2 Br 13328 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br, 6- 2 Br 13329 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Me 2 13330 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3, 6-Br 2 13331 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-CF.sub.3 2 13332 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-CF.sub.3 2 13333 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-CF.sub.3 2 13334 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Cl 2 13335 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3 2 13336 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-CF.sub.3 2 13337 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-CF.sub.3 2 13338 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Br 2 13339 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-SnMe.sub.3 2 13340 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Me 2 13341 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OH 2 13342 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMe 2 13343 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMeF 2 13344 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OCF.sub.3 2 13345 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OEtF 2 13346 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OPrF 2 13347 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Br 2 13348 FCH.sub.2--CH--CH--CH.sub.2 2-OMe, 4-Br 2 13349 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Br 2 13350 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Br 2 13351 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Br 2 13352 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Br 2 13353 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OH 2 13354 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMe 2 13355 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMeF 2 13356 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OCF.sub.3 2 13357 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OEtF 2 13358 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OPrF 2 13359 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-I 2 13360 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-I 2 13361 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-I 2 13362 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-I 2 13363 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-I 2 13364 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-I 2 13365 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OH 2 13366 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMe 2 13367 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMeF 2 13368 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OCF.sub.3 2 13369 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OEtF 2 13370 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OPrF 2 13371 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-SnMe.sub.3 2 13372 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-SnMe.sub.3 2 13373 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-SnMe.sub.3 2 13374 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-SnMe.sub.3 2 13375 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-SnMe.sub.3 2 13376 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-SnMe.sub.3 2 13377 Bn H 1 13378 Bn 2-t-Bu 1 13379 Bn 2-Br 1 13380 Bn 3-Br 1 13381 Bn 4-Br 1 13382 Bn 2-I 1 13383 Bn 3-I 1 13384 Bn 4-I 1 13385 Bn 2-SnMe.sub.3 1 13386 Bn 3-SnMe.sub.3 1 13387 Bn 4-SnMe.sub.3 1 13388 Bn 2-Me 1 13389 Bn 3-Me 1 13390 Bn 4-Me 1 13391 Bn 2-OH 1 13392 Bn 3-OH 1 13393 Bn 4-OH 1 13394 Bn 2-OMe 1 13395 Bn 3-OMe 1 13396 Bn 4-OMe 1 13397 Bn 2-OMeF 1 13398 Bn 3-OMeF 1 13399 Bn 4-OMeF 1 13400 Bn 2-OCF.sub.3 1 13401 Bn 3-OCF.sub.3 1 13402 Bn 4-OCF.sub.3 1 13403 Bn 2-OEtF 1 13404 Bn 3-OEtF 1 13405 Bn 4-OEtF 1 13406 Bn 2-OPrF 1 13407 Bn 3-OPrF 1 13408 Bn 4-OPrF 1 13409 Bn 2-SH 1 13410 Bn 3-SH 1 13411 Bn 4-SH 1 13412 Bn 2-SMe 1 13413 Bn 3-SMe 1 13414 Bn 4-SMe 1 13415 Bn 2-SMeF 1 13416 Bn 3-SMeF 1 13417 Bn 4-SMeF 1 13418 Bn 2-SCF.sub.3 1 13419 Bn 3-SCF.sub.3 1 13420 Bn 4-SCF.sub.3 1 13421 Bn 2-SEtF 1 13422 Bn 3-SEtF 1 13423 Bn 4-SEtF 1

13424 Bn 2-SPrF 1 13425 Bn 3-SPrF 1 13426 Bn 4-SPrF 1 13427 Bn 2-OMe, 4-OMe 1 13428 Bn 2-Me, 5-OH 1 13429 Bn 2-Me, 5-OMe 1 13430 Bn 2-Me, 5-OMeF 1 13431 Bn 2-Me, 5-OEtF 1 13432 Bn 2-Me, 5-OPrF 1 13433 Bn 2-Me, 4-OH 1 13434 Bn 2-Me, 4-OMe 1 13435 Bn 2-Me, 4-OMeF 1 13436 Bn 2-Me, 4-OCF.sub.3 1 13437 Bn 2-Me, 4-OEtF 1 13438 Bn 2-Me, 4-OPrF 1 13439 Bn 2-OH, 4-Me 1 13440 Bn 2-OMe, 4-Me 1 13441 Bn 2-OMeF, 4-Me 1 13442 Bn 2-OCF.sub.3, 4-Me 1 13443 Bn 2-OEtF, 4-Me 1 13444 Bn 2-OPrF, 4-Me 1 13445 Bn 2-Cl, 4-OH 1 13446 Bn 2-Cl, 4-OMe 1 13447 Bn 2-Cl, 4-OMeF 1 13448 Bn 2-Cl, 4-OCF.sub.3 1 13449 Bn 2-Cl, 4-OEtF 1 13450 Bn 2-Cl, 4-OPrF 1 13451 Bn 2-F, 4-F 1 13452 Bn 2-Cl, 4-Cl 1 13453 Bn 2-Cl, 4-F 1 13454 Bn 2-Cl, 4-NO.sub.2 1 13455 Bn 2-Cl, 4-NH.sub.2 1 13456 Bn 2-Cl, 4-NHMe 1 13457 Bn 2-Cl, 4-NMe.sub.2 1 13458 Bn 2-Cl, 4-NMe.sub.3OTf 1 13459 Bn 2-Cl, 4-NMe.sub.3I 1 13460 Bn 2-Cl, 5-F 1 13461 Bn 2-Cl, 5-NO.sub.2 1 13462 Bn 2-Cl, 5-NH.sub.2 1 13463 Bn 2-Cl, 5-NHMe 1 13464 Bn 2-Cl, 5-NMe.sub.2 1 13465 Bn 2-Cl, 5-NMe.sub.3OTf 1 13466 Bn 2-Cl, 5-NMe.sub.3I 1 13467 Bn 2-F, 4-Cl 1 13468 Bn 2-NO.sub.2, 4-Cl 1 13469 Bn 2-NH.sub.2, 4-Cl 1 13470 Bn 2-NHMe, 4-Cl 1 13471 Bn 2-NMe.sub.2, 4-Cl 1 13472 Bn 2-NMe.sub.3OTf, 4-Cl 1 13473 Bn 2-NMe.sub.3I, 4-Cl 1 13474 Bn 2-F, 5-Cl 1 13475 Bn 2-NO.sub.2, 5-Cl 1 13476 Bn 2-NH.sub.2, 5-Cl 1 13477 Bn 2-NHMe, 5-Cl 1 13478 Bn 2-NMe.sub.2, 5-Cl 1 13479 Bn 2-NMe.sub.3OTf, 5-Cl 1 13480 Bn 2-NMe.sub.3I, 5-Cl 1 13481 Bn 2-Br, 4-F 1 13482 Bn 2-Br, 4-NO.sub.2 1 13483 Bn 2-Br, 4-NH.sub.2 1 13484 Bn 2-Br, 4-NHMe 1 13485 Bn 2-Br, 4-NMe.sub.2 1 13486 Bn 2-Br, 4-NMe.sub.3OTf 1 13487 Bn 2-Br, 4-NMe.sub.3I 1 13488 Bn 2-Br, 5-F 1 13489 Bn 2-Br, 5-NO.sub.2 1 13490 Bn 2-Br, 5-NH.sub.2 1 13491 Bn 2-Br, 5-NHMe 1 13492 Bn 2-Br, 5-NMe.sub.2 1 13493 Bn 2-Br, 5-NMe.sub.3OTf 1 13494 Bn 2-Br, 5-NMe.sub.3I 1 13495 Bn 2-F, 4-Br 1 13496 Bn 2-NO.sub.2, 4-Br 1 13497 Bn 2-NH.sub.2, 4-Br 1 13498 Bn 2-NHMe, 4-Br 1 13499 Bn 2-NMe.sub.2, 4-Br 1 13500 Bn 2-NMe.sub.3OTf, 4-Br 1 13501 Bn 2-NMe.sub.3I, 4-Br 1 13502 Bn 2-I, 4-F 1 13503 Bn 2-I, 4-NO.sub.2 1 13504 Bn 2-I, 4-NH.sub.2 1 13505 Bn 2-I, 4-NHMe 1 13506 Bn 2-I, 4-NMe.sub.2 1 13507 Bn 2-I, 4-NMe.sub.3OTf 1 13508 Bn 2-I, 4-NMe,1 1 13509 Bn 2-F, 4-I 1 13510 Bn 2-NO.sub.2, 4-I 1 13511 Bn 2-NH.sub.2, 4-I 1 13512 Bn 2-NHMe, 4-I 1 13513 Bn 2-NMe.sub.2, 4-I 1 13514 Bn 2-NMe.sub.3OTf, 4-I 1 13515 Bn 2-NMe.sub.3I, 4-I 1 13516 Bn 2-Me, 3-F 1 13517 Bn 2-Me, 3-NO.sub.2 1 13518 Bn 2-Me, 3-NH.sub.2 1 13519 Bn 2-Me, 3-NHMe 1 13520 Bn 2-Me, 3-NMe.sub.2 1 13521 Bn 2-Me, 3-NMe.sub.3OTf 1 13522 Bn 2-Me, 3-NMe.sub.3I 1 13523 Bn 2-Me, 4-F 1 13524 Bn 2-Me, 4-NO.sub.2 1 13525 Bn 2-Me, 4-NH.sub.2 1 13526 Bn 2-Me, 4-NHMe 1 13527 Bn 2-Me, 4-NMe.sub.2 1 13528 Bn 2-Me, 4-NMe.sub.3OTf 1 13529 Bn 2-Me, 4-NMe.sub.3I 1 13530 Bn 2-Me, 5-F 1 13531 Bn 2-Me, 5-NO.sub.2 1 13532 Bn 2-Me, 5-NH.sub.2 1 13533 Bn 2-Me, 5-NHMe 1 13534 Bn 2-Me, 5-NMe.sub.2 1 13535 Bn 2-Me, 5-NMe.sub.3OTf 1 13536 Bn 2-Me, 5-NMe.sub.3I 1 13537 Bn 2-F, 4-Me 1 13538 Bn 2-NO.sub.2, 4-Me 1 13539 Bn 2-NH.sub.2, 4-Me 1 13540 Bn 2-NHMe, 4-Me 1 13541 Bn 2-NMe.sub.2, 4-Me 1 13542 Bn 2-NMe.sub.3, 4-Me 1 13543 Bn 2-NMe.sub.3OTf, 4-Me 1 13544 Bn 2-NMe.sub.3I, 4-Me 1 13545 Bn 2-SnMe.sub.3, 4-F 1 13546 Bn 2-SnMe.sub.3, 5-F 1 13547 Bn 2-F, 4-SnMe.sub.3 1 13548 Bn 2-Br, 6-Cl, 4-F 1 13549 Bn 2-Br, 6-Cl, 4-NO.sub.2 1 13550 Bn 2-Br, 6-Cl, 4-NH.sub.2 1 13551 Bn 2-Br, 6-Cl, 4- 1 NHMe 13552 Bn 2-Br, 6-Cl, 4-NMe.sub.2 1 13553 Bn 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 13554 Bn 2-Br, 6-Cl, 4- 1 NMe.sub.3I 13555 Bn 2-Me, 6-Cl, 4-F 1 13556 Bn 2-SnMe.sub.3, 6-Cl, 4-F 1 13557 Bn 2-Cl, 4-Me 1 13558 Bn 2-Cl, 4-Br 1 13559 Bn 2-Cl, 4-SnMe.sub.3 1 13560 Bn 2-Br, 4-Cl 1 13561 Bn 2-SnMe.sub.3, 4-Cl 1 13562 Bn 2-Me, 4-Cl 1 13563 Bn 2-Br, 4-Br 1 13564 Bn 2-Br, 4-Me 1 13565 Bn 2-Br, 4-SnMe.sub.3 1 13566 Bn 2-SnMe.sub.3, 4-Br 1 13567 Bn 2-Me, 4-Br 1 13568 Bn 2-Me, 4-SnMe.sub.3 1 13569 Bn 2-SnMe.sub.3, 4-Me 1 13570 Bn 2-Me, 4-Me 1 13571 Bn 2-Et, 4-Br 1 13572 Bn 2-Et, 4-SnMe.sub.3 1 13573 Bn 2-Et, 4-Me 1 13574 Bn 2-Me, 4-Me, 6-Me 1 13575 Bn 2-Me, 4-Br, 6-Me 1 13576 Bn 2-Me, 4-SnMe.sub.3, 6- 1 Me 13577 Bn 2-Et, 6-Me 1 13578 Bn 2-Br, 4-i-Pr 1 13579 Bn 2-SnMe.sub.3, 4-i-Pr 1 13580 Bn 2-Me, 4-i-Pr 1 13581 Bn 2-Br, 4-Br, 6-Br 1 13582 Bn 2-Br, 4-Me, 6-Br 1 13583 Bn 2-Br, 4-SnMe.sub.3, 6- 1 Br 13584 Bn 2-SnMe.sub.3, 4-Br, 6- 1 Br 13585 Bn 2-Br, 4-Br, 6-Me 1 13586 Bn 2-Br, 4-CF.sub.3, 6-Br 1 13587 Bn 2-Br, 4-Br, 6-CF.sub.3 1 13588 Bn 2-CF.sub.3, 4-CF.sub.3 1 13589 Bn 2-Cl, 4-CF.sub.3 1 13590 Bn 2-CF.sub.3, 4-Cl 1 13591 Bn 2-Br, 4-CF.sub.3 1 13592 Bn 2-SnMe.sub.3, 4-CF.sub.3 1 13593 Bn 2-Me, 4-CF.sub.3 1 13594 Bn 2-CF.sub.3, 4-Br 1 13595 Bn 2-CF.sub.3, 4-SnMe.sub.3 1 13596 Bn 2-CF.sub.3, 4-Me 1 13597 Bn 2-Br, 4-OH 1 13598 Bn 2-Br, 4-OMe 1 13599 Bn 2-Br, 4-OMeF 1 13600 Bn 2-Br, 4-OCF.sub.3 1 13601 Bn 2-Br, 4-OEtF 1 13602 Bn 2-Br, 4-OPrF 1 13603 Bn 2-OH, 4-Br 1 13604 Bn 2-OMe, 4-Br 1 13605 Bn 2-OMeF, 4-Br 1 13606 Bn 2-OCF.sub.3, 4-Br 1 13607 Bn 2-OEtF, 4-Br 1 13608 Bn 2-OPrF, 4-Br 1 13609 Bn 2-I, 4-OH 1 13610 Bn 2-I, 4-OMe 1 13611 Bn 2-I, 4-OMeF 1 13612 Bn 2-I, 4-OCF.sub.3 1 13613 Bn 2-I, 4-OEtF 1 13614 Bn 2-I, 4-OPrF 1 13615 Bn 2-OH, 4-I 1 13616 Bn 2-OMe, 4-I 1 13617 Bn 2-OMeF, 4-I 1 13618 Bn 2-OCF.sub.3, 4-I 1 13619 Bn 2-OEtF, 4-I 1 13620 Bn 2-OPrF, 4-I 1 13621 Bn 2-SnMe.sub.3, 4-OH 1 13622 Bn 2-SnMe.sub.3, 4-OMe 1 13623 Bn 2-SnMe.sub.3, 4-OMeF 1 13624 Bn 2-SnMe.sub.3, 4-OCF.sub.3 1 13625 Bn 2-SnMe.sub.3, 4-OEtF 1 13626 Bn 2-SnMe.sub.3, 4-OPrF 1 13627 Bn 2-OH, 4-SnMe.sub.3 1 13628 Bn 2-OMe, 4-SnMe.sub.3 1 13629 Bn 2-OMeF, 4-SnMe.sub.3 1 13630 Bn 2-OCF.sub.3, 4-SnMe.sub.3 1 13631 Bn 2-OEtF, 4-SnMe.sub.3 1 13632 Bn 2-OPrF, 4-SnMe.sub.3 1 13633 Bn H 2 13634 Bn 2-t-Bu 2 13635 Bn 2-Br 2 13636 Bn 3-Br 2 13637 Bn 4-Br 2 13638 Bn 2-I 2 13639 Bn 3-I 2 13640 Bn 4-I 2 13641 Bn 2-SnMe.sub.3 2 13642 Bn 3-SnMe.sub.3 2 13643 Bn 4-SnMe.sub.3 2 13644 Bn 2-Me 2 13645 Bn 3-Me 2 13646 Bn 4-Me 2 13647 Bn 2-OH 2 13648 Bn 3-OH 2 13649 Bn 4-OH 2 13650 Bn 2-OMe 2 13651 Bn 3-OMe 2 13652 Bn 4-OMe 2 13653 Bn 2-OMeF 2 13654 Bn 3-OMeF 2 13655 Bn 4-OMeF 2 13656 Bn 2-OCF.sub.3 2 13657 Bn 3-OCF.sub.3 2 13658 Bn 4-OCF.sub.3 2 13659 Bn 2-OEtF 2 13660 Bn 3-OEtF 2 13661 Bn 4-OEtF 2 13662 Bn 2-OPrF 2 13663 Bn 3-OPrF 2 13664 Bn 4-OPrF 2 13665 Bn 2-SH 2 13666 Bn 3-SH 2 13667 Bn 4-SH 2 13668 Bn 2-SMe 2

13669 Bn 3-SMe 2 13670 Bn 4-SMe 2 13671 Bn 2-SMeF 2 13672 Bn 3-SMeF 2 13673 Bn 4-SMeF 2 13674 Bn 2-SCF.sub.3 2 13675 Bn 3-SCF.sub.3 2 13676 Bn 4-SCF.sub.3 2 13677 Bn 2-SEtF 2 13678 Bn 3-SEtF 2 13679 Bn 4-SEtF 2 13680 Bn 2-SPrF 2 13681 Bn 3-SPrF 2 13682 Bn 4-SPrF 2 13683 Bn 2-OMe, 4-OMe 2 13684 Bn 2-Me, 5-OH 2 13685 Bn 2-Me, 5-OMe 2 13686 Bn 2-Me, 5-OMeF 2 13687 Bn 2-Me, 5-OEtF 2 13688 Bn 2-Me, 5-OPrF 2 13689 Bn 2-Me, 4-OH 2 13690 Bn 2-Me, 4-OMe 2 13691 Bn 2-Me, 4-OMeF 2 13692 Bn 2-Me, 4-OCF.sub.3 2 13693 Bn 2-Me, 4-OEtF 2 13694 Bn 2-Me, 4-OPrF 2 13695 Bn 2-OH, 4-Me 2 13696 Bn 2-OMe, 4-Me 2 13697 Bn 2-OMeF, 4-Me 2 13698 Bn 2-OCF.sub.3, 4-Me 2 13699 Bn 2-OEtF, 4-Me 2 13700 Bn 2-OPrF, 4-Me 2 13701 Bn 2-Cl, 4-OH 2 13702 Bn 2-Cl, 4-OMe 2 13703 Bn 2-Cl, 4-OMeF 2 13704 Bn 2-Cl, 4-OCF.sub.3 2 13705 Bn 2-Cl, 4-OEtF 2 13706 Bn 2-Cl, 4-OPrF 2 13707 Bn 2-F, 4-F 2 13708 Bn 2-Cl, 4-Cl 2 13709 Bn 2-Cl, 4-F 2 13710 Bn 2-Cl, 4-NO.sub.2 2 13711 Bn 2-Cl, 4-NH.sub.2 2 13712 Bn 2-Cl, 4-NHMe 2 13713 Bn 2-Cl, 4-NMe.sub.2 2 13714 Bn 2-Cl, 4-NMe.sub.3OTf 2 13715 Bn 2-Cl, 4-NMe.sub.3I 2 13716 Bn 2-Cl, 5-F 2 13717 Bn 2-Cl, 5-NO.sub.2 2 13718 Bn 2-Cl, 5-NH.sub.2 2 13719 Bn 2-Cl, 5-NHMe 2 13720 Bn 2-Cl, 5-NMe.sub.2 2 13721 Bn 2-Cl, 5-NMe.sub.3OTf 2 13722 Bn 2-Cl, 5-NMe.sub.3I 2 13723 Bn 2-F, 4-Cl 2 13724 Bn 2-NO.sub.2, 4-Cl 2 13725 Bn 2-NH.sub.2, 4-Cl 2 13726 Bn 2-NHMe, 4-Cl 2 13727 Bn 2-NMe.sub.2, 4-Cl 2 13728 Bn 2-NMe.sub.3OTf, 4-Cl 2 13729 Bn 2-NMe.sub.3I, 4-Cl 2 13730 Bn 2-F, 5-Cl 2 13731 Bn 2-NO.sub.2, 5-Cl 2 13732 Bn 2-NH.sub.2, 5-Cl 2 13733 Bn 2-NHMe, 5-Cl 2 13734 Bn 2-NMe.sub.2, 5-Cl 2 13735 Bn 2-NMe.sub.3OTf, 5-Cl 2 13736 Bn 2-NMe.sub.3I, 5-Cl 2 13737 Bn 2-Br, 4-F 2 13738 Bn 2-Br, 4-NO.sub.2 2 13739 Bn 2-Br, 4-NH.sub.2 2 13740 Bn 2-Br, 4-NHMe 2 13741 Bn 2-Br, 4-NMe.sub.2 2 13742 Bn 2-Br, 4-NMe.sub.3OTf 2 13743 Bn 2-Br, 4-NMe.sub.3I 2 13744 Bn 2-Br, 5-F 2 13745 Bn 2-Br, 5-NO.sub.2 2 13746 Bn 2-Br, 5-NH.sub.2 2 13747 Bn 2-Br, 5-NHMe 2 13748 Bn 2-Br, 5-NMe.sub.2 2 13749 Bn 2-Br, 5-NMe.sub.3OTf 2 13750 Bn 2-Br, 5-NMe.sub.3I 2 13751 Bn 2-F, 4-Br 2 13752 Bn 2-NO.sub.2, 4-Br 2 13753 Bn 2-NH.sub.2, 4-Br 2 13754 Bn 2-NHMe, 4-Br 2 13755 Bn 2-NMe.sub.2, 4-Br 2 13756 Bn 2-NMe.sub.3OTf, 4-Br 2 13757 Bn 2-NMe.sub.3I, 4-Br 2 13758 Bn 2-I, 4-F 2 13759 Bn 2-I, 4-NO.sub.2 2 13760 Bn 2-I, 4-NH.sub.2 2 13761 Bn 2-I, 4-NHMe 2 13762 Bn 2-I, 4-NMe.sub.2 2 13763 Bn 2-I, 4-NMe.sub.3OTf 2 13764 Bn 2-I, 4-NMe.sub.3I 2 13765 Bn 2-F, 4-I 2 13766 Bn 2-NO.sub.2, 4-I 2 13767 Bn 2-NH.sub.2, 4-I 2 13768 Bn 2-NHMe, 4-I 2 13769 Bn 2-NMe.sub.2, 4-I 2 13770 Bn 2-NMe.sub.3OTf, 4-I 2 13771 Bn 2-NMe.sub.3I, 4-I 2 13772 Bn 2-Me, 3-F 2 13773 Bn 2-Me, 3-NO.sub.2 2 13774 Bn 2-Me, 3-NH.sub.2 2 13775 Bn 2-Me, 3-NHMe 2 13776 Bn 2-Me, 3-NMe.sub.2 2 13777 Bn 2-Me, 3-NMe.sub.3OTf 2 13778 Bn 2-Me, 3-NMe.sub.3I 2 13779 Bn 2-Me, 4-F 2 13780 Bn 2-Me, 4-NO.sub.2 2 13781 Bn 2-Me, 4-NH.sub.2 2 13782 Bn 2-Me, 4-NHMe 2 13783 Bn 2-Me, 4-NMe.sub.2 2 13784 Bn 2-Me, 4-NMe.sub.3OTf 2 13785 Bn 2-Me, 4-NMe.sub.3I 2 13786 Bn 2-Me, 5-F 2 13787 Bn 2-Me, 5-NO.sub.2 2 13788 Bn 2-Me, 5-NH.sub.2 2 13789 Bn 2-Me, 5-NHMe 2 13790 Bn 2-Me, 5-NMe.sub.2 2 13791 Bn 2-Me, 5-NMe.sub.3OTf 2 13792 Bn 2-Me, 5-NMe.sub.3I 2 13793 Bn 2-F, 4-Me 2 13794 Bn 2-NO.sub.2, 4-Me 2 13795 Bn 2-NH.sub.2, 4-Me 2 13796 Bn 2-NHMe, 4-Me 2 13797 Bn 2-NMe.sub.2, 4-Me 2 13798 Bn 2-NMe.sub.3, 4-Me 2 13799 Bn 2-NMe.sub.3OTf, 4-Me 2 13800 Bn 2-NMe.sub.3I, 4-Me 2 13801 Bn 2-SnMe.sub.3, 4-F 2 13802 Bn 2-SnMe.sub.3, 5-F 2 13803 Bn 2-F, 4-SnMe.sub.3 2 13804 Bn 2-Br, 6-Cl, 4-F 2 13805 Bn 2-Br, 6-Cl, 4-NO.sub.2 2 13806 Bn 2-Br, 6-Cl, 4-NH.sub.2 2 13807 Bn 2-Br, 6-Cl, 4- 2 NHMe 13808 Bn 2-Br, 6-Cl, 4-NMe.sub.2 2 13809 Bn 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 13810 Bn 2-Br, 6-Cl, 4- 2 NMe.sub.3I 13811 Bn 2-Me, 6-Cl, 4-F 2 13812 Bn 2-SnMe.sub.3, 6-Cl, 4-F 2 13813 Bn 2-Cl, 4-Me 2 13814 Bn 2-Cl, 4-Br 2 13815 Bn 2-Cl, 4-SnMe.sub.3 2 13816 Bn 2-Br, 4-Cl 2 13817 Bn 2-SnMe.sub.3, 4-Cl 2 13818 Bn 2-Me, 4-Cl 2 13819 Bn 2-Br, 4-Br 2 13820 Bn 2-Br, 4-Me 2 13821 Bn 2-Br, 4-SnMe.sub.3 2 13822 Bn 2-SnMe.sub.3, 4-Br 2 13823 Bn 2-Me, 4-Br 2 13824 Bn 2-Me, 4-SnMe.sub.3 2 13825 Bn 2-SnMe.sub.3, 4-Me 2 13826 Bn 2-Me, 4-Me 2 13827 Bn 2-Et, 4-Br 2 13828 Bn 2-Et, 4-SnMe.sub.3 2 13829 Bn 2-Et, 4-Me 2 13830 Bn 2-Me, 4-Me, 6-Me 2 13831 Bn 2-Me, 4-Br, 6-Me 2 13832 Bn 2-Me, 4-SnMe.sub.3, 6- 2 Me 13833 Bn 2-Et, 6-Me 2 13834 Bn 2-Br, 4-i-Pr 2 13835 Bn 2-SnMe.sub.3, 4-i-Pr 2 13836 Bn 2-Me, 4-i-Pr 2 13837 Bn 2-Br, 4-Br, 6-Br 2 13838 Bn 2-Br, 4-Me, 6-Br 2 13839 Bn 2-Br, 4-SnMe.sub.3, 6- 2 Br 13840 Bn 2-SnMe.sub.3, 4-Br, 6- 2 Br 13841 Bn 2-Br, 4-Br, 6-Me 2 13842 Bn 2-Br, 4-CF.sub.3, 6-Br 2 13843 Bn 2-Br, 4-Br, 6-CF.sub.3 2 13844 Bn 2-CF.sub.3, 4-CF.sub.3 2 13845 Bn 2-Cl, 4-CF.sub.3 2 13846 Bn 2-CF.sub.3, 4-Cl 2 13847 Bn 2-Br, 4-CF.sub.3 2 13848 Bn 2-SnMe.sub.3, 4-CF.sub.3 2 13849 Bn 2-Me, 4-CF.sub.3 2 13850 Bn 2-CF.sub.3, 4-Br 2 13851 Bn 2-CF.sub.3, 4-SnMe.sub.3 2 13852 Bn 2-CF.sub.3, 4-Me 2 13853 Bn 2-Br, 4-OH 2 13854 Bn 2-Br, 4-OMe 2 13855 Bn 2-Br, 4-OMeF 2 13856 Bn 2-Br, 4-OCF.sub.3 2 13857 Bn 2-Br, 4-OEtF 2 13858 Bn 2-Br, 4-OPrF 2 13859 Bn 2-OH, 4-Br 2 13860 Bn 2-OMe, 4-Br 2 13861 Bn 2-OMeF, 4-Br 2 13862 Bn 2-OCF.sub.3, 4-Br 2 13863 Bn 2-OEtF, 4-Br 2 13864 Bn 2-OPrF, 4-Br 2 13865 Bn 2-I, 4-OH 2 13866 Bn 2-I, 4-OMe 2 13867 Bn 2-I, 4-OMeF 2 13868 Bn 2-I, 4-OCF.sub.3 2 13869 Bn 2-I, 4-OEtF 2 13870 Bn 2-I, 4-OPrF 2 13871 Bn 2-OH, 4-I 2 13872 Bn 2-OMe, 4-I 2 13873 Bn 2-OMeF, 4-I 2 13874 Bn 2-OCF.sub.3, 4-I 2 13875 Bn 2-OEtF, 4-I 2 13876 Bn 2-OPrF, 4-I 2 13877 Bn 2-SnMe.sub.3, 4-OH 2 13878 Bn 2-SnMe.sub.3, 4-OMe 2 13879 Bn 2-SnMe.sub.3, 4-OMeF 2 13880 Bn 2-SnMe.sub.3, 4-OCF.sub.3 2 13881 Bn 2-SnMe.sub.3, 4-OEtF 2 13882 Bn 2-SnMe.sub.3, 4-OPrF 2 13883 Bn 2-OH, 4-SnMe.sub.3 2 13884 Bn 2-OMe, 4-SnMe.sub.3 2 13885 Bn 2-OMeF, 4-SnMe.sub.3 2 13886 Bn 2-OCF.sub.3, 4-SnMe.sub.3 2 13887 Bn 2-OEtF, 4-SnMe.sub.3 2 13888 Bn 2-OPrF, 4-SnMe.sub.3 2 13889 H H 1 13890 H 2-t-Bu 1 13891 H 2-Br 1 13892 H 3-Br 1 13893 H 4-Br 1 13894 H 2-I 1 13895 H 3-I 1 13896 H 4-I 1 13897 H 2-SnMe.sub.3 1 13898 H 3-SnMe.sub.3 1 13899 H 4-SnMe.sub.3 1 13900 H 2-Me 1 13901 H 3-Me 1 13902 H 4-Me 1 13903 H 2-OH 1 13904 H 3-OH 1 13905 H 4-OH 1 13906 H 2-OMe 1 13907 H 3-OMe 1 13908 H 4-OMe 1 13909 H 2-OMeF 1 13910 H 3-OMeF 1 13911 H 4-OMeF 1 13912 H 2-OCF.sub.3 1 13913 H 3-OCF.sub.3 1

13914 H 4-OCF.sub.3 1 13915 H 2-OEtF 1 13916 H 3-OEtF 1 13917 H 4-OEtF 1 13918 H 2-OPrF 1 13919 H 3-OPrF 1 13920 H 4-OPrF 1 13921 H 2-SH 1 13922 H 3-SH 1 13923 H 4-SH 1 13924 H 2-SMe 1 13925 H 3-SMe 1 13926 H 4-SMe 1 13927 H 2-SMeF 1 13928 H 3-SMeF 1 13929 H 4-SMeF 1 13930 H 2-SCF.sub.3 1 13931 H 3-SCF.sub.3 1 13932 H 4-SCF.sub.3 1 13933 H 2-SEtF 1 13934 H 3-SEtF 1 13935 H 4-SEtF 1 13936 H 2-SPrF 1 13937 H 3-SPrF 1 13938 H 4-SPrF 1 13939 H 2-OMe, 4-OMe 1 13940 H 2-Me, 5-OH 1 13941 H 2-Me, 5-OMe 1 13942 H 2-Me, 5-OMeF 1 13943 H 2-Me, 5-OEtF 1 13944 H 2-Me, 5-OPrF 1 13945 H 2-Me, 4-OH 1 13946 H 2-Me, 4-OMe 1 13947 H 2-Me, 4-OMeF 1 13948 H 2-Me, 4-OCF.sub.3 1 13949 H 2-Me, 4-OEtF 1 13950 H 2-Me, 4-OPrF 1 13951 H 2-OH, 4-Me 1 13952 H 2-OMe, 4-Me 1 13953 H 2-OMeF, 4-Me 1 13954 H 2-OCF.sub.3, 4-Me 1 13955 H 2-OEtF, 4-Me 1 13956 H 2-OPrF, 4-Me 1 13957 H 2-Cl, 4-OH 1 13958 H 2-Cl, 4-OMe 1 13959 H 2-Cl, 4-OMeF 1 13960 H 2-Cl, 4-OCF.sub.3 1 13961 H 2-Cl, 4-OEtF 1 13962 H 2-Cl, 4-OPrF 1 13963 H 2-F, 4-F 1 13964 H 2-Cl, 4-Cl 1 13965 H 2-Cl, 4-F 1 13966 H 2-Cl, 4-NO.sub.2 1 13967 H 2-Cl, 4-NH.sub.2 1 13968 H 2-Cl, 4-NHMe 1 13969 H 2-Cl, 4-NMe.sub.2 1 13970 H 2-Cl, 4-NMe.sub.3OTf 1 13971 H 2-Cl, 4-NMe.sub.3I 1 13972 H 2-Cl, 5-F 1 13973 H 2-Cl, 5-NO.sub.2 1 13974 H 2-Cl, 5-NH.sub.2 1 13975 H 2-Cl, 5-NHMe 1 13976 H 2-Cl, 5-NMe.sub.2 1 13977 H 2-Cl, 5-NMe.sub.3OTf 1 13978 H 2-Cl, 5-NMe.sub.3I 1 13979 H 2-F, 4-Cl 1 13980 H 2-NO.sub.2, 4-Cl 1 13981 H 2-NH.sub.2, 4-Cl 1 13982 H 2-NHMe, 4-Cl 1 13983 H 2-NMe.sub.2, 4-Cl 1 13984 H 2-NMe.sub.3OTf, 4-Cl 1 13985 H 2-NMe.sub.3I, 4-Cl 1 13986 H 2-F, 5-Cl 1 13987 H 2-NO.sub.2, 5-Cl 1 13988 H 2-NH.sub.2, 5-Cl 1 13989 H 2-NHMe, 5-Cl 1 13990 H 2-NMe.sub.2, 5-Cl 1 13991 H 2-NMe.sub.3OTf, 5-Cl 1 13992 H 2-NMe.sub.3I, 5-Cl 1 13993 H 2-Br, 4-F 1 13994 H 2-Br, 4-NO.sub.2 1 13995 H 2-Br, 4-NH.sub.2 1 13996 H 2-Br, 4-NHMe 1 13997 H 2-Br, 4-NMe.sub.2 1 13998 H 2-Br, 4-NMe.sub.3OTf 1 13999 H 2-Br, 4-NMe.sub.3I 1 14000 H 2-Br, 5-F 1 14001 H 2-Br, 5-NO.sub.2 1 14002 H 2-Br, 5-NH.sub.2 1 14003 H 2-Br, 5-NHMe 1 14004 H 2-Br, 5-NMe.sub.2 1 14005 H 2-Br, 5-NMe.sub.3OTf 1 14006 H 2-Br, 5-NMe.sub.3I 1 14007 H 2-F, 4-Br 1 14008 H 2-NO.sub.2, 4-Br 1 14009 H 2-NH.sub.2, 4-Br 1 14010 H 2-NHMe, 4-Br 1 14011 H 2-NMe.sub.2, 4-Br 1 14012 H 2-NMe.sub.3OTf, 4-Br 1 14013 H 2-NMe.sub.3I, 4-Br 1 14014 H 2-I, 4-F 1 14015 H 2-I, 4-NO.sub.2 1 14016 H 2-I, 4-NH.sub.2 1 14017 H 2-I, 4-NHMe 1 14018 H 2-I, 4-NMe.sub.2 1 14019 H 2-I, 4-NMe.sub.3OTf 1 14020 H 2-I, 4-NMe.sub.3I 1 14021 H 2-F, 4-I 1 14022 H 2-NO.sub.2, 4-I 1 14023 H 2-NH.sub.2, 4-I 1 14024 H 2-NHMe, 4-I 1 14025 H 2-NMe.sub.2, 4-I 1 14026 H 2-NMe.sub.3OTf, 4-I 1 14027 H 2-NMe.sub.3I, 4-I 1 14028 H 2-Me, 3-F 1 14029 H 2-Me, 3-NO.sub.2 1 14030 H 2-Me, 3-NH.sub.2 1 14031 H 2-Me, 3-NHMe 1 14032 H 2-Me, 3-NMe.sub.2 1 14033 H 2-Me, 3-NMe.sub.3OTf 1 14034 H 2-Me, 3-NMe.sub.3I 1 14035 H 2-Me, 4-F 1 14036 H 2-Me, 4-NO.sub.2 1 14037 H 2-Me, 4-NH.sub.2 1 14038 H 2-Me, 4-NHMe 1 14039 H 2-Me, 4-NMe.sub.2 1 14040 H 2-Me, 4-NMe.sub.3OTf 1 14041 H 2-Me, 4-NMe.sub.3I 1 14042 H 2-Me, 5-F 1 14043 H 2-Me, 5-NO.sub.2 1 14044 H 2-Me, 5-NH.sub.2 1 14045 H 2-Me, 5-NHMe 1 14046 H 2-Me, 5-NMe.sub.2 1 14047 H 2-Me, 5-NMe.sub.3OTf 1 14048 H 2-Me, 5-NMe.sub.3I 1 14049 H 2-F, 4-Me 1 14050 H 2-NO.sub.2, 4-Me 1 14051 H 2-NH.sub.2, 4-Me 1 14052 H 2-NHMe, 4-Me 1 14053 H 2-NMe.sub.2, 4-Me 1 14054 H 2-NHMe.sub.3, 4-Me 1 14055 H 2-NMe.sub.3OTf, 4-Me 1 14056 H 2-NMe.sub.3I, 4-Me 1 14057 H 2-SnMe.sub.3, 4-F 1 14058 H 2-SnMe.sub.3, 5-F 1 14059 H 2-F, 4-SnMe.sub.3 1 14060 H 2-Br, 6-Cl, 4-F 1 14061 H 2-Br, 6-Cl, 4-NO.sub.2 1 14062 H 2-Br, 6-Cl, 4-NH.sub.2 1 14063 H 2-Br, 6-Cl, 4- NHMe 14064 H 2-Br, 6-Cl, 4-NMe.sub.2 1 14065 H 2-Br, 6-Cl, 4- 1 NMe.sub.3OTf 14066 H 2-Br, 6-Cl, 4- 1 NMe.sub.3I 14067 H 2-Me, 6-Cl, 4-F 1 14068 H 2-SnMe.sub.3, 6-Cl, 4-F 1 14069 H 2-Cl, 4-Me 1 14070 H 2-Cl, 4-Br 1 14071 H 2-Cl, 4-SnMe.sub.3 1 14072 H 2-Br, 4-Cl 1 14073 H 2-SnMe.sub.3, 4-Cl 1 14074 H 2-Me, 4-Cl 1 14075 H 2-Br, 4-Br 1 14076 H 2-Br, 4-Me 1 14077 H 2-Br, 4-SnMe.sub.3 1 14078 H 2-SnMe.sub.3, 4-Br 1 14079 H 2-Me, 4-Br 1 14080 H 2-Me, 4-SnMe.sub.3 1 14081 H 2-SnMe.sub.3, 4-Me 1 14082 H 2-Me, 4-Me 1 14083 H 2-Et, 4-Br 1 14084 H 2-Et, 4-SnMe.sub.3 1 14085 H 2-Et, 4-Me 1 14086 H 2-Me, 4-Me, 6-Me 1 14087 H 2-Me, 4-Br, 6-Me 1 14088 H 2-Me, 4-SnMe.sub.3, 6- 1 Me 14089 H 2-Et, 6-Me 1 14090 H 2-Br, 4-i-Pr 1 14091 H 2-SnMe.sub.3, 4-i-Pr 1 14092 H 2-Me, 4-i-Pr 1 14093 H 2-Br, 4-Br, 6-Br 1 14094 H 2-Br, 4-Me, 6-Br 1 14095 H 2-Br, 4-SnMe.sub.3, 6- 1 Br 14096 H 2-SnMe.sub.3, 4-Br, 6- 1 Br 14097 H 2-Br, 4-Br, 6-Me 1 14098 H 2-Br, 4-CF.sub.3, 6-Br 1 14099 H 2-Br, 4-Br, 6-CF.sub.3 1 14100 H 2-CF.sub.3, 4-CF.sub.3 1 14101 H 2-Cl, 4-CF.sub.3 1 14102 H 2-CF.sub.3, 4-Cl 1 14103 H 2-Br, 4-CF.sub.3 1 14104 H 2-SnMe.sub.3, 4-CF.sub.3 1 14105 H 2-Me, 4-CF.sub.3 1 14106 H 2-CF.sub.3, 4-Br 1 14107 H 2-CF.sub.3, 4-SnMe.sub.3 1 14108 H 2-CF.sub.3, 4-Me 1 14109 H 2-Br, 4-OH 1 14110 H 2-Br, 4-OMe 1 14111 H 2-Br, 4-OMeF 1 14112 H 2-Br, 4-OCF.sub.3 1 14113 H 2-Br, 4-OEtF 1 14114 H 2-Br, 4-OPrF 1 14115 H 2-OH, 4-Br 1 14116 H 2-OMe, 4-Br 1 14117 H 2-OMeF, 4-Br 1 14118 H 2-OCF.sub.3, 4-Br 1 14119 H 2-OEtF, 4-Br 1 14120 H 2-OPrF, 4-Br 1 14121 H 2-I, 4-OH 1 14122 H 2-I, 4-OMe 1 14123 H 2-I, 4-OMeF 1 14124 H 2-I, 4-OCF.sub.3 1 14125 H 2-I, 4-OEtF 1 14126 H 2-I, 4-OPrF 1 14127 H 2-OH, 4-I 1 14128 H 2-OMe, 4-I 1 14129 H 2-OMeF, 4-I 1 14130 H 2-OCF.sub.3, 4-I 1 14131 H 2-OEtF, 4-I 1 14132 H 2-OPrF, 4-I 1 14133 H 2-SnMe.sub.3, 4-OH 1 14134 H 2-SnMe.sub.3, 4-OMe 1 14135 H 2-SnMe.sub.3, 4-OMeF 1 14136 H 2-SnMe.sub.3, 4-OCF.sub.3 1 14137 H 2-SnMe.sub.3, 4-OEtF 1 14138 H 2-SnMe.sub.3, 4-OPrF 1 14139 H 2-OH, 4-SnMe.sub.3 1 14140 H 2-OMe, 4-SnMe.sub.3 1 14141 H 2-OMeF, 4-SnMe.sub.3 1 14142 H 2-OCF.sub.3, 4-SnMe.sub.3 1 14143 H 2-OEtF, 4-SnMe.sub.3 1 14144 H 2-OPrF, 4-SnMe.sub.3 1 14145 H H 2 14146 H 2-t-Bu 2 14147 H 2-Br 2 14148 H 3-Br 2 14149 H 4-Br 2 14150 H 2-I 2 14151 H 3-I 2 14152 H 4-I 2 14153 H 2-SnMe.sub.3 2 14154 H 3-SnMe.sub.3 2 14155 H 4-SnMe.sub.3 2 14156 H 2-Me 2 14157 H 3-Me 2 14158 H 4-Me 2

14159 H 2-OH 2 14160 H 3-OH 2 14161 H 4-OH 2 14162 H 2-OMe 2 14163 H 3-OMe 2 14164 H 4-OMe 2 14165 H 2-OMeF 2 14166 H 3-OMeF 2 14167 H 4-OMeF 2 14168 H 2-OCF.sub.3 2 14169 H 3-OCF.sub.3 2 14170 H 4-OCF.sub.3 2 14171 H 2-OEtF 2 14172 H 3-OEtF 2 14173 H 4-OEtF 2 14174 H 2-OPrF 2 14175 H 3-OPrF 2 14176 H 4-OPrF 2 14177 H 2-SH 2 14178 H 3-SH 2 14179 H 4-SH 2 14180 H 2-SMe 2 14181 H 3-SMe 2 14182 H 4-SMe 2 14183 H 2-SMeF 2 14184 H 3-SMeF 2 14185 H 4-SMeF 2 14186 H 2-SCF.sub.3 2 14187 H 3-SCF.sub.3 2 14188 H 4-SCF.sub.3 2 14189 H 2-SEtF 2 14190 H 3-SEtF 2 14191 H 4-SEtF 2 14192 H 2-SPrF 2 14193 H 3-SPrF 2 14194 H 4-SPrF 2 14195 H 2-OMe, 4-OMe 2 14196 H 2-Me, 5-OH 2 14197 H 2-Me, 5-OMe 2 14198 H 2-Me, 5-OMeF 2 14199 H 2-Me, 5-OEtF 2 14200 H 2-Me, 5-OPrF 2 14201 H 2-Me, 4-OH 2 14202 H 2-Me, 4-OMe 2 14203 H 2-Me, 4-OMeF 2 14204 H 2-Me, 4-OCF.sub.3 2 14205 H 2-Me, 4-OEtF 2 14206 H 2-Me, 4-OPrF 2 14207 H 2-OH, 4-Me 2 14208 H 2-OMe, 4-Me 2 14209 H 2-OMeF, 4-Me 2 14210 H 2-OCF.sub.3, 4-Me 2 14211 H 2-OEtF, 4-Me 2 14212 H 2-OPrF, 4-Me 2 14213 H 2-Cl, 4-OH 2 14214 H 2-Cl, 4-OMe 2 14215 H 2-Cl, 4-OMeF 2 14216 H 2-Cl, 4-OCF.sub.3 2 14217 H 2-Cl, 4-OEtF 2 14218 H 2-Cl, 4-OPrF 2 14219 H 2-F, 4-F 2 14220 H 2-Cl, 4-Cl 2 14221 H 2-Cl, 4-F 2 14222 H 2-Cl, 4-NO.sub.2 2 14223 H 2-Cl, 4-NH.sub.2 2 14224 H 2-Cl, 4-NHMe 2 14225 H 2-Cl, 4-NMe.sub.2 2 14226 H 2-Cl, 4-NMe.sub.3OTf 2 14227 H 2-Cl, 4-NMe.sub.3I 2 14228 H 2-Cl, 5-F 2 14229 H 2-Cl, 5-NO.sub.2 2 14230 H 2-Cl, 5-NH.sub.2 2 14231 H 2-Cl, 5-NHMe 2 14232 H 2-Cl, 5-NMe.sub.2 2 14233 H 2-Cl, 5-NMe.sub.3OTf 2 14234 H 2-Cl, 5-NMe.sub.3I 2 14235 H 2-F, 4-Cl 2 14236 H 2-NO.sub.2, 4-Cl 2 14237 H 2-NH.sub.2, 4-Cl 2 14238 H 2-NHMe, 4-Cl 2 14239 H 2-NMe.sub.2, 4-Cl 2 14240 H 2-NMe.sub.3OTf, 4-Cl 2 14241 H 2-NMe.sub.3I, 4-Cl 2 14242 H 2-F, 5-Cl 2 14243 H 2-NO.sub.2, 5-Cl 2 14244 H 2-NH.sub.2, 5-Cl 2 14245 H 2-NHMe, 5-Cl 2 14246 H 2-NMe.sub.2, 5-Cl 2 11247 H 2-NMe.sub.3OTf, 5-Cl 2 14248 H 2-NMe.sub.3I, 5-Cl 2 14249 H 2-Br, 4-F 2 14250 H 2-Br, 4-NO.sub.2 2 14251 H 2-Br, 4-NH.sub.2 2 14252 H 2-Br, 4-NHMe 2 14253 H 2-Br, 4-NMe.sub.2 2 14254 H 2-Br, 4-NMe.sub.3OTf 2 14255 H 2-Br, 4-NMe.sub.3I 2 14256 H 2-Br, 5-F 2 14257 H 2-Br, 5-NO.sub.2 2 14258 H 2-Br, 5-NH.sub.2 2 14259 H 2-Br, 5-NHMe 2 14260 H 2-Br, 5-NMe.sub.2 2 14261 H 2-Br, 5-NMe.sub.3OTf 2 14262 H 2-Br, 5-NMe.sub.3I 2 14263 H 2-F, 4-Br 2 14264 H 2-NO.sub.2, 4-Br 2 14265 H 2-NH.sub.2, 4-Br 2 14266 H 2-NHMe, 4-Br 2 14267 H 2-NMe.sub.2, 4-Br 2 14268 H 2-NMe.sub.3OTf, 4-Br 2 14269 H 2-NMe.sub.3I, 4-Br 2 14270 H 2-I, 4-F 2 14271 H 2-I, 4-NO.sub.2 2 14272 H 2-I, 4-NH.sub.2 2 14273 H 2-I, 4-NHMe 2 14274 H 2-I, 4-NMe.sub.2 2 14275 H 2-I, 4-NMe.sub.3OTf 2 14276 H 2-I, 4-NMe.sub.3I 2 14277 H 2-F, 44 2 14278 H 2-NO.sub.2, 4-I 2 14279 H 2-NH.sub.2, 4-I 2 14280 H 2-NHMe, 4-I 2 14281 H 2-NMe.sub.2, 4-I 2 14282 H 2-NMe.sub.3OTf, 4-I 2 14283 H 2-NMe.sub.3I, 4-I 2 14284 H 2-Me, 3-F 2 14285 H 2-Me, 3-NO.sub.2 2 14286 H 2-Me, 3-NH.sub.2 2 14287 H 2-Me, 3-NHMe 2 14288 H 2-Me, 3-NMe.sub.2 2 14289 H 2-Me, 3-NMe.sub.3OTf 2 14290 H 2-Me, 3-NMe.sub.3I 2 14291 H 2-Me, 4-F 2 14292 H 2-Me, 4-NO.sub.2 2 14293 H 2-Me, 4-NH.sub.2 2 14294 H 2-Me, 4-NHMe 2 14295 H 2-Me, 4-NMe.sub.2 2 14296 H 2-Me, 4-NMe.sub.3OTf 2 14297 H 2-Me, 4-NMe.sub.3I 2 14298 H 2-Me, 5-F 2 14299 H 2-Me, 5-NO.sub.2 2 14300 H 2-Me, 5-N142 2 14301 H 2-Me, 5-NHMe 2 14302 H 2-Me, 5-NMe.sub.2 2 14303 H 2-Me, 5-NMe.sub.3OTf 2 14304 H 2-Me, 5-NMe.sub.3I 2 14305 H 2-F, 4-Me 2 14306 H 2-NO.sub.2, 4-Me 2 14307 H 2-NH.sub.2, 4-Me 2 14308 H 2-NHMe, 4-Me 2 14309 H 2-NMe.sub.2, 4-Me 2 14310 H 2-NMe.sub.3, 4-Me 2 14311 H 2-NMe.sub.3OTf, 4-Me 2 14312 H 2-NMe.sub.3I, 4-Me 2 14313 H 2-SnMe.sub.3, 4-F 2 14314 H 2-SnMe.sub.3, 5-F 2 14315 H 2-F, 4-SnMe.sub.3 2 14316 H 2-Br, 6-Cl, 4-F 2 14317 H 2-Br, 6-Cl, 4-NO.sub.2 2 14318 H 2-Br, 6-Cl, 4-NH.sub.2 2 14319 H 2-Br, 6-Cl, 4- 2 NHMe 14320 H 2-Br, 6-Cl, 4-NMe.sub.2 2 H 2-Br, 6-Cl, 4- 2 NMe.sub.3OTf 14322 H 2-Br, 6-Cl, 4- 2 NMe.sub.3I 14323 H 2-Me, 6-Cl, 4-F 2 14324 H 2-SnMe.sub.3, 6-Cl, 4-F 2 14325 H 2-Cl, 4-Me 2 14326 H 2-Cl, 4-Br 2 14327 H 2-Cl, 4-SnMe.sub.3 2 14328 H 2-Br, 4-Cl 2 14329 H 2-SnMe.sub.3, 4-Cl 2 14330 H 2-Me, 4-Cl 2 14331 H 2-Br, 4-Br 2 14332 H 2-Br, 4-Me 2 14333 H 2-Br, 4-SnMe.sub.3 2 14334 H 2-SnMe.sub.3, 4-Br 2 14335 H 2-Me, 4-Br 2 14336 H 2-Me, 4-SnMe.sub.3 2 14337 H 2-SnMe.sub.3, 4-Me 2 14338 H 2-Me, 4-Me 2 14339 H 2-Et, 4-Br 2 14340 H 2-Et, 4-SnMe.sub.3 2 14341 H 2-Et, 4-Me 2 14342 H 2-Me, 4-Me, 6-Me 2 14343 H 2-Me, 4-Br, 6-Me 2 14344 H 2-Me, 4-SnMe.sub.3, 6- 2 Me 14345 H 2-Et, 6-Me 2 14346 H 2-Br, 4-i-Pr 2 14347 H 2-SnMe.sub.3, 4-i-Pr 2 14348 H 2-Me, 4-i-Pr 2 14349 H 2-Br, 4-Br, 6-Br 2 14350 H 2-Br, 4-Me, 6-Br 2 14351 H 2-Br, 4-SnMe.sub.3, 6- 2 Br 14352 H 2-SnMe.sub.3, 4-Br, 6- 2 Br 14353 H 2-Br, 4-Br, 6-Me 2 14354 H 2-Br, 4-CF.sub.3, 6-Br 2 14355 H 2-Br, 4-Br, 6-CF.sub.3 2 14356 H 2-CF.sub.3, 4-CF.sub.3 2 14357 H 2-Cl, 4-CF.sub.3 2 14358 H 2-CF.sub.3, 4-Cl 2 14359 H 2-Br, 4-CF.sub.3 2 14360 H 2-SnMe.sub.3, 4-CF.sub.3 2 14361 H 2-Me, 4-CF.sub.3 2 14362 H 2-CF.sub.3, 4-Br 2 14363 H 2-CF.sub.3, 4-SnMe.sub.3 2 14364 H 2-CF.sub.3, 4-Me 2 14365 H 2-Br, 4-OH 2 14366 H 2-Br, 4-OMe 2 14367 H 2-Br, 4-OMeF 2 14368 H 2-Br, 4-OCF.sub.3 2 14369 H 2-Br, 4-OEtF 2 14370 H 2-Br, 4-OPrF 2 14371 H 2-OH, 4-Br 2 14372 H 2-OMe, 4-Br 2 14373 H 2-OMeF, 4-Br 2 14374 H 2-OCF.sub.3, 4-Br 2 14375 H 2-OEtF, 4-Br 2 14376 H 2-OPrF, 4-Br 2 14377 H 2-I, 4-OH 2 14378 H 2-I, 4-OMe 2 14379 H 2-I, 4-OMeF 2 14380 H 2-I, 4-OCF.sub.3 2 14381 H 2-I, 4-OEtF 2 14382 H 2-I, 4-OPrF 2 14383 H 2-OH, 4-I 2 14384 H 2-OMe, 4-I 2 14385 H 2-OMeF, 4-I 2 14386 H 2-OCF.sub.3, 4-I 2 14387 H 2-OEtF, 4-I 2 14388 H 2-OPrF, 4-I 2 14389 H 2-SnMe.sub.3, 4-OH 2 14390 H 2-SnMe.sub.3, 4-OMe 2 14391 H 2-SnMe.sub.3, 4-OMeF 2 14392 H 2-SnMe.sub.3, 4-OCF.sub.3 2 14393 H 2-SnMe.sub.3, 4-OEtF 2 14394 H 2-SnMe.sub.3, 4-OPrF 2 14395 H 2-OH, 4-SnMe.sub.3 2 14396 H 2-OMe, 4-SnMe.sub.3 2 14397 H 2-OMeF, 4-SnMe.sub.3 2 14398 H 2-OCF.sub.3, 4-SnMe.sub.3 2 14399 H 2-OEtF, 4-SnMe.sub.3 2 14400 H 2-OPrF, 4-SnMe.sub.3 2

TABLE-US-00025 TABLE 10 ##STR00097## Substituent list for compounds of general structure XV. Compound # R.sup.2 = R.sup.3 = 14401 Bu H 14402 Bu 2-t-Bu 14403 Bu 2-Br 14404 Bu 3-Br 14405 Bu 4-Br 14406 Bu 2-I 14407 Bu 3-I 14408 Bu 4-I 14409 Bu 2-SnMe.sub.3 14410 Bu 3-SnMe.sub.3 14411 Bu 4-SnMe.sub.3 14412 Bu 2-Me 14413 Bu 3-Me 14414 Bu 4-Me 14415 Bu 2-OH 14416 Bu 3-OH 14417 Bu 4-OH 14418 Bu 2-OMe 14419 Bu 3-OMe 14420 Bu 4-OMe 14421 Bu 2-OMeF 14422 Bu 3-OMeF 14423 Bu 4-OMeF 14424 Bu 2-OCF.sub.3 14425 Bu 3-OCF.sub.3 14426 Bu 4-OCF.sub.3 14427 Bu 2-OEtF 14428 Bu 3-OEtF 14429 Bu 4-OEtF 14430 Bu 2-OPrF 14431 Bu 3-OPrF 14432 Bu 4-OPrF 14433 Bu 2-SH 14434 Bu 3-SH 14435 Bu 4-SH 14436 Bu 2-SMe 14437 Bu 3-SMe 14438 Bu 4-SMe 14439 Bu 2-SMeF 14440 Bu 3-SMeF 14441 Bu 4-SMeF 14442 Bu 2-SCF.sub.3 14443 Bu 3-SCF.sub.3 14444 Bu 4-SCF.sub.3 14445 Bu 2-SEtF 14446 Bu 3-SEtF 14447 Bu 4-SEtF 14448 Bu 2-SPrF 14449 Bu 3-SPrF 14450 Bu 4-SPrF 14451 Bu 2-OMe, 4-OMe 14452 Bu 2-Me, 5-OH 14453 Bu 2-Me, 5-OMe 14454 Bu 2-Me, 5-OMeF 14455 Bu 2-Me, 5-OEtF 14456 Bu 2-Me, 5-OPrF 14457 Bu 2-Me, 4-OH 14458 Bu 2-Me, 4-OMe 14459 Bu 2-Me, 4-OMeF 14460 Bu 2-Me, 4-OCF.sub.3 14461 Bu 2-Me, 4-OEtF 14462 Bu 2-Me, 4-OPrF 14463 Bu 2-OH, 4-Me 14464 Bu 2-OMe, 4-Me 14465 Bu 2-OMeF, 4-Me 14466 Bu 2-OCF.sub.3, 4-Me 14467 Bu 2-OEtF, 4-Me 14468 Bu 2-OPrF, 4-Me 14469 Bu 2-Cl, 4-OH 14470 Bu 2-Cl, 4-OMe 14471 Bu 2-Cl, 4-OMeF 14472 Bu 2-Cl, 4-OCF.sub.3 14473 Bu 2-Cl, 4-OEtF 14474 Bu 2-Cl, 4-OPrF 14475 Bu 2-F, 4-F 14476 Bu 2-Cl, 4-Cl 14477 Bu 2-Cl, 4-F 14478 Bu 2-Cl, 4-NO.sub.2 14479 Bu 2-Cl, 4-NH2 14480 Bu 2-Cl, 4-NHMe 14481 Bu 2-Cl, 4-NMe.sub.2 14482 Bu 2-Cl, 4-NMe.sub.3OTf 14483 Bu 2-Cl, 4-NMe.sub.3I 14484 Bu 2-Cl, 5-F 14485 Bu 2-Cl, 5-NO.sub.2 14486 Bu 2-Cl, 5-NH.sub.2 14487 Bu 2-Cl, 5-NHMe 14488 Bu 2-Cl, 5-NMe.sub.2 14489 Bu 2-Cl, 5-NMe.sub.3OTf 14490 Bu 2-Cl, 5-NMe.sub.3I 14491 Bu 2-F, 4-Cl 14492 flu 2-NO.sub.2, 4-Cl 14493 Bu 2-NH.sub.2, 4-Cl 14494 Bu 2-NHMe, 4-Cl 14495 Bu 2-NMe.sub.2, 4-Cl 14496 Bu 2-NMe.sub.3OTf, 4-Cl 14497 Bu 2-NMe.sub.3I, 4-Cl 14498 Bu 2-F, 5-Cl 14499 Bu 2-NO.sub.2, 5-Cl 14500 Bu 2-NH.sub.2, 5-Cl 14501 Bu 2-NHMe, 5-Cl 14502 Bu 2-NMe.sub.2, 5-Cl 14503 Bu 2-NMe.sub.3OTf, 5-Cl 14504 Bu 2-NMe.sub.3I, 5-Cl 14505 Bu 2-Br, 4-F 14506 Bu 2-Br, 4-NO.sub.2 14507 Bu 2-Br, 4-NH.sub.2 14508 Bu 2-Br, 4-NHMe 14509 Bu 2-Br, 4-NMe.sub.2 14510 Bu 2-Br, 4-NMe.sub.3OTf 14511 Bu 2-Br, 4-NMe.sub.3I 14512 Bu 2-Br, 5-F 14513 Bu 2-Br, 5-NO.sub.2 14514 Bu 2-Br, 5-NH.sub.2 14515 Bu 2-Br, 5-NHMe 14516 Bu 2-Br, 5-NMe.sub.2 14517 Bu 2-Br, 5-NMe.sub.3OTf 14518 Bu 2-Br, 5-NMe.sub.3I 14519 Bu 2-F, 4-Br 14520 Bu 2-NO.sub.2, 4-Br 14521 Bu 2-NH.sub.2, 4-Br 14522 Bu 2-NHMe, 4-Br 14523 Bu 2-NMe.sub.2, 4-Br 14524 Bu 2-NMe.sub.3OTf, 4-Br 14525 Bu 2-NMe.sub.3I, 4-Br 14526 Bu 2-I, 4-F 14527 Bu 2-I, 4-NO.sub.2 14528 Bu 2-I, 4-NH.sub.2 14529 Bu 2-I, 4-NHMe 14530 Bu 2-I, 4-NMe.sub.2 14531 Bu 2-I, 4-NMe.sub.3OTf 14532 Bu 2-I, 4-NMe.sub.3I 14533 Bu 2-F, 4-I 14534 Bu 2-NO.sub.2, 4-I 14535 Bu 2-NH.sub.2, 4-I 14536 Bu 2-NHMe, 4-I 14537 Bu 2-NMe.sub.2, 4-I 14538 Bu 2-NMe.sub.3OTf, 4-I 14539 Bu 2-NMe.sub.3I, 4-I 14540 Bu 2-Me, 3-F 14541 Bu 2-Me, 3-NO.sub.2 14542 Bu 2-Me, 3-NH.sub.2 14543 Bu 2-Me, 3-NHMe 14544 Bu 2-Me, 3-NMe.sub.2 14545 Bu 2-Me, 3-NMe.sub.3OTf 14546 Bu 2-Me, 3-NMe.sub.3I 14547 Bu 2-Me, 4-F 14548 Bu 2-Me, 4-NO.sub.2 14549 Bu 2-Me, 4-NH.sub.2 14550 Bu 2-Me, 4-NHMe 14551 Bu 2-Me, 4-NMe.sub.2 14552 Bu 2-Me, 4-NMe.sub.3OTf 14553 Bu 2-Me, 4-NMe.sub.3I 14554 Bu 2-Me, 5-F 14555 Bu 2-Me, 5-NO.sub.2 14556 Bu 2-Me, 5-NH.sub.2 14557 Bu 2-Me, 5-NHMe 14558 Bu 2-Me, 5-NMe.sub.2 14559 Bu 2-Me, 5-NMe.sub.3OTf 14560 Bu 2-Me, 5-NMe.sub.3I 14561 Bu 2-F, 4-Me 14562 Bu 2-NO.sub.2, 4-Me 14563 Bu 2-NH.sub.2, 4-Me 14564 Bu 2-NHMe, 4-Me 14565 Bu 2-NMe.sub.2, 4-Me 14566 Bu 2-NMe.sub.3, 4-Me 14567 Bu 2-NMe.sub.3OTf, 4-Me 14568 Bu 2-NMe.sub.3I, 4-Me 14569 Bu 2-SnMe.sub.3, 4-F 14570 Bu 2-SnMe.sub.3, 5-F 14571 Bu 2-F, 4-SnMe.sub.3 14572 Bu 2-Br, 6-Cl, 4-F 14573 Bu 2-Br, 6-Cl, 4-NO.sub.2 14574 Bu 2-Br, 6-Cl, 4-NH.sub.2 14575 Bu 2-Br, 6-Cl, 4-NHMe 14576 Bu 2-Br, 6-Cl, 4-NMe.sub.2 14577 Bu 2-Br, 6-Cl, 4-NMe.sub.3OTf 14578 Bu 2-Br, 6-Cl, 4-NMe.sub.3I 14579 Bu 2-Me, 6-Cl, 4-F 14580 Bu 2-SnMe.sub.3, 6-Cl, 4-F 14581 Bu 2-Cl, 4-Me 14582 Bu 2-Cl, 4-Br 14583 Bu 2-Cl, 4-SnMe.sub.3 14584 Bu 2-Br, 4-Cl 14585 Bu 2-SnMe.sub.3, 4-Cl 14586 Bu 2-Me, 4-Cl 14587 Bu 2-Br, 4-Br 14588 Bu 2-Br, 4-Me 14589 Bu 2-Br, 4-SnMe.sub.3 14590 Bu 2-SnMe.sub.3, 4-Br 14591 Bu 2-Me, 4-Br 14592 Bu 2-Me, 4-SnMe.sub.3 14593 Bu 2-SnMe.sub.3, 4-Me 14594 Bu 2-Me, 4-Me 14595 Bu 2-Et, 4-Br 14596 Bu 2-Et, 4-SnMe.sub.3 14597 Bu 2-Et, 4-Me 14598 Bu 2-Me, 4-Me, 6-Me 14599 Bu 2-Me, 4-Br, 6-Me 14600 Bu 2-Me, 4-SnMe.sub.3, 6-Me 14601 Bu 2-Et, 6-Me 14602 Bu 2-Br, 4-i-Pr 14603 Bu 2-SnMe.sub.3, 4-i-Pr 14604 Bu 2-Me, 4-i-Pr 14605 Be 2-Br, 4-Br, 6-Br 14606 Bu 2-Br, 4-Me, 6-Br 14607 Bu 2-Br, 4-SnMe.sub.3, 6-Br 14608 Bu 2-SnMe.sub.3, 4-Br, 6-Br 14609 Bu 2-Br, 4-Br, 6-Me 14610 Bu 2-Br, 4-CF.sub.3, 6-Br 14611 Bu 2-Br, 4-Br, 6-CF.sub.3 14612 Bu 2-CF.sub.3, 4-CF.sub.3 14613 Bu 2-Cl, 4-CF.sub.3 14614 Bu 2-CF.sub.3, 4-Cl 14615 Bu 2-Br, 4-CF.sub.3 14616 Bu 2-SnMe.sub.3, 4-CF.sub.3 14617 Bu 2-Me, 4-CF.sub.3 14618 Bu 2-CF.sub.3, 4-Br 14619 Bu 2-CF.sub.3, 4-SnMe.sub.3 14620 Bu 2-CF.sub.3, 4-Me 14621 Bu 2-Br, 4-OH 14622 Bu 2-Br, 4-OMe 14623 Bu 2-Br, 4-OMeF 14624 Bu 2-Br, 4-OCF.sub.3 14625 Bu 2-Br, 4-OEtF 14626 Bu 2-Br, 4-OPrF 14627 Bu 2-OH, 4-Br 14628 Bu 2-OMe, 4-Br 14629 Bu 2-OMeF, 4-Br 14630 Bu 2-OCF.sub.3, 4-Br 14631 Bu 2-OEtF, 4-Br 14632 Bu 2-OPrF, 4-Br 14633 Bu 2-I, 4-OH 14634 Bu 2-I, 4-OMe 14635 Bu 2-I, 4-OMeF 14636 Bu 2-I, 4-OCF.sub.3 14637 Bu 2-I, 4-OEtF 14644 Bu 2-OPrF, 4-I 14645 Bu 2-SnMe.sub.3, 4-OH 14646 Bu 2-SnMe.sub.3, 4-OMe 14647 Bu 2-SnMe.sub.3, 4-OMeF 14648 Bu 2-SnMe.sub.3, 4-OCF.sub.3 14649 Bu 2-SnMe 3, 4-OEtF

14650 Bu 2-SnMe.sub.3, 4-OPrF 14651 Bu 2-OH, 4-SnMe.sub.3 14652 Bu 2-OMe, 4-SnMe.sub.3 14653 Bu 2-OMeF, 4-SnMe.sub.3 14654 Bu 2-OCF.sub.3, 4-SnMe.sub.3 14655 Bu 2-OEtF, 4-SnMe.sub.3 14656 Bu 2-OPrF, 4-SnMe.sub.3 14657 Bu-F H 14658 Bu-F 2-t-Bu 14659 Bu-F 2-Br 14660 Bu-F 3-Br 14661 Bu-F 4-Br 14662 Bu-F 2-I 14663 Bu-F 3-I 14664 Bu-F 4-I 14665 Bu-F 2-SnMe.sub.3 14666 Bu-F 3-SnMe.sub.3 14667 Bu-F 4-SnMe.sub.3 14668 Bu-F 2-Me 14669 Bu-F 3-Me 14670 Bu-F 4-Me 14671 Bu-F 2-OH 14672 Bu-F 3-OH 14673 Bu-F 4-OH 14674 Bu-F 2-OMe 14675 Bu-F 3-OMe 14676 Bu-F 4-OMe 14677 Bu-F 2-OMeF 14678 Bu-F 3-OMeF 14679 Bu-F 4-OMeF 14680 Bu-F 2-OCF.sub.3 14681 Bu-F 3-OCF.sub.3 14682 Bu-F 4-OCF.sub.3 14683 Bu-F 2-OEtF 14684 Bu-F 3-OEtF 14685 Bu-F 4-OEtF 14686 Bu-F 2-OPrF 14687 Bu-F 3-OPrF 14688 Bu-F 4-OPrF 14689 Bu-F 2-SH 14690 Bu-F 3-SH 14691 Bu-F 4-SH 14692 Bu-F 2-SMe 14693 Bu-F 3-SMe 14694 Bu-F 4-SMe 14695 Bu-F 2-SMeF 14696 Bu-F 3-SMeF 14697 Bu-F 4-SMeF 14698 Bu-F 2-SCF.sub.3 14699 Bu-F 3-SCF.sub.3 14700 Bu-F 4-SCF.sub.3 14701 Bu-F 2-SEtF 14702 Bu-F 3-SEtF 14703 Bu-F 4-SEtF 14704 Bu-F 2-SPrF 14705 Bu-F 3-SPrF 14706 Bu-F 4-SPrF 14707 Bu-F 2-OMe, 4-OMe 14708 Bu-F 2-Me, 5-OH 14709 Bu-F 2-Me, 5-OMe 14710 Bu-F 2-Me, 5-OMeF 14711 Bu-F 2-Me, 5-OEtF 14712 Bu-F 2-Me, 5-OPrF 14713 Bu-F 2-Me, 4-OH 14714 Bu-F 2-Me, 4-OMe 14715 Bu-F 2-Me, 4-OMeF 14716 Bu-F 2-Me, 4-OCF.sub.3 14717 Bu-F 2-Me, 4-OEtF 14718 Bu-F 2-Me, 4-OPrF 14719 Bu-F 2-OH, 4-Me 14720 Bu-F 2-OMe, 4-Me 14721 Bu-F 2-OMeF, 4-Me 14722 Bu-F 2-OCF.sub.3, 4-Me 14723 Bu-F 2-OEtF, 4-Me 14724 Bu-F 2-OPrF, 4-Me 14725 Bu-F 2-Cl, 4-OH 14726 Bu-F 2-Cl, 4-OMe 14727 Bu-F 2-Cl, 4-OMeF 14728 Bu-F 2-Cl, 4-OCF.sub.3 14729 Bu-F 2-Cl, 4-OEtF 14730 Bu-F 2-Cl, 4-OPrF 14731 Bu-F 2-F, 4-F 14732 Bu-F 2-Cl, 4-Cl 14733 Bu-F 2-Cl, 4-F 14734 Bu-F 2-Cl, 4-NO.sub.2 14735 Bu-F 2-Cl, 4-NH.sub.2 14736 Bu-F 2-Cl, 4-NHMe 14737 Bu-F 2-Cl, 4-NMe.sub.2 14738 Bu-F 2-Cl, 4-NMe.sub.3OTf 14739 Bu-F 2-Cl, 4-NMe.sub.3I 14740 Bu-F 2-Cl, 5-F 14741 Bu-F 2-Cl, 5-NO.sub.2 14742 Bu-F 2-Cl, 5-NH.sub.2 14743 Bu-F 2-Cl, 5-NHMe 14744 Bu-F 2-Cl, 5-NMe.sub.2 14745 Bu-F 2-Cl, 5-NMe.sub.3OTf 14746 Bu-F 2-Cl, 5- NMe.sub.3I 14747 Bu-F 2-F, 4-Cl 14748 Bu-F 2-NO.sub.2, 4-Cl 14749 Bu-F 2-NH.sub.2, 4-Cl 14750 Bu-F 2-NHMe, 4-Cl 14751 Bu-F 2-NMe.sub.2, 4-Cl 14752 Bu-F 2-NMe.sub.3OTf, 4-Cl 14753 Bu-F 2-NMe.sub.3I, 4-Cl 14754 Bu-F 2-F, 5-Cl 14755 Bu-F 2-NO.sub.2, 5-Cl 14756 Bu-F 2-NH.sub.2, 5-Cl 14757 Bu-F 2-NHMe, 5-Cl 14758 Bu-F 2-NMe.sub.2, 5-Cl 14759 Bu-F 2-NMe.sub.3OTf, 5-Cl 14760 Bu-F 2-NMe.sub.3I, 5-Cl 14761 Bu-F 2-Br, 4-F 14762 Bu-F 2-Br, 4-NO.sub.2 14763 Bu-F 2-Br, 4-NH.sub.2 14764 Bu-F 2-Br, 4-NHMe 14765 Bu-F 2-Br, 4-NMe.sub.2 14766 Bu-F 2-Br, 4-NMe.sub.3OTf 14767 Bu-F 2-Br, 4-NMe.sub.3I 14768 Bu-F 2-Br, 5-F 14769 Bu-F 2-Br, 5-NO.sub.2 14770 Bu-F 2-Br, 5-NH.sub.2 14771 Bu-F 2-Br, 5-NHMe 14772 Bu-F 2-Br, 5-NMe.sub.2 14773 Bu-F 2-Br, 5-NMe.sub.3OTf 14774 Bu-F 2-Br, 5-NMe.sub.3I 14775 Bu-F 2-F, 4-Br 14776 Bu-F 2-NO.sub.2, 4-Br 14777 Bu-F 2-NH.sub.2, 4-Br 14778 Bu-F 2-NHMe, 4-Br 14779 Bu-F 2-NMe.sub.2, 4-Br 14780 Bu-F 2-NMe.sub.3OTf, 4-Br 14781 Bu-F 2-NMe.sub.3I, 4-Br 14782 Bu-F 2-I, 4-F 14783 Bu-F 2-I, 4-NO.sub.2 14784 Bu-F 2-I, 4-NH.sub.2 14785 Bu-F 2-I, 4-NHMe 14786 Bu-F 2-I, 4-NMe.sub.2 14787 Bu-F 2-I, 4-NMe.sub.3OTf 14788 Bu-F 2-I, 4-NMe.sub.3I 14789 Bu-F 2-F, 4-I 14790 Bu-F 2-NO.sub.2, 4-I 14791 Bu-F 2-NH.sub.2, 4-I 14792 Bu-F 2-NHMe, 4-I 14793 Bu-F 2-NMe.sub.2, 4-I 14794 Bu-F 2-NMe.sub.3OTf, 4-I 14795 Bu-F 2-NMe.sub.3I, 4-I 14796 Bu-F 2-Me, 3-F 14797 Bu-F 2-Me, 3-NO.sub.2 14798 Bu-F 2-Me, 3-NH.sub.2 14799 Bu-F 2-Me, 3-NHMe 14800 Bu-F 2-Me, 3-NMe.sub.2 14801 Bu-F 2-Me, 3-NMe.sub.3OTf 14802 Bu-F 2-Me, 3-NMe.sub.3I 14803 Bu-F 2-Me, 4-F 14804 Bu-F 2-Me, 4-NO.sub.2 14805 Bu-F 2-Me, 4-NH.sub.2 14806 Bu-F 2-Me, 4-NHMe 14807 Bu-F 2-Me, 4-NMe.sub.2 14808 Bu-F 2-Me, 4-NMe.sub.3OTf 14809 Bu-F 2-Me, 4-NMe.sub.3I 14810 Bu-F 2-Me, 5-F 14811 Bu-F 2-Me, 5-NO.sub.2 14812 Bu-F 2-Me, 5-NH.sub.2 14813 Bu-F 2-Me, 5-NHMe 14814 Bu-F 2-Me, 5-NMe.sub.2 14815 Bu-F 2-Me, 5-NMe.sub.3OTf 14816 Bu-F 2-Me, 5-NMe.sub.3I 14817 Bu-F 2-F, 4-Me 14818 Bu-F 2-NO.sub.2, 4-Me 14819 Bu-F 2-NH.sub.2, 4-Me 14820 Bu-F 2-NHMe, 4-Me 14821 Bu-F 2-NMe.sub.2, 4-Me 14822 Bu-F 2-NMe.sub.3, 4-Me 14823 Bu-F 2-NMe.sub.3OTf, 4-Me 14824 Bu-F 2-NMe.sub.3I, 4-Me 14825 Bu-F 2-SnMe.sub.3, 4-F 14826 Bu-F 2-SnMe.sub.3, 5-F 14827 Bu-F 2-F, 4-SnMe.sub.3 14828 Bu-F 2-Br, 6-Cl, 4-F 14829 Bu-F 2-Br, 6-Cl, 4-NO.sub.2 14830 Bu-F 2-Br, 6-Cl, 4-NH.sub.2 14831 Bu-F 2-Br, 6-Cl, 4-NHMe 14832 Bu-F 2-Br, 6-Cl, 4-NMe.sub.2 14833 Bu-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 14834 Bu-F 2-Br, 6-Cl, 4-NMe.sub.3I 14835 Bu-F 2-Me, 6-Cl, 4-F 14836 Bu-F 2-SnMe.sub.3, 6-Cl, 4-F 14837 Bu-F 2-Cl, 4-Me 14838 Bu-F 2-Cl, 4-Br 14839 Bu-F 2-Cl, 4-SnMe.sub.3 14840 Bu-F 2-Br, 4-Cl 14841 Bu-F 2-SnMe.sub.3, 4-Cl 14842 Bu-F 2-Me, 4-Cl 14843 Bu-F 2-Br, 4-Br 14844 Bu-F 2-Br, 4-Me 14845 Bu-F 2-Br, 4-SnMe.sub.3 14846 Bu-F 2-SnMe.sub.3, 4-Br 14847 Bu-F 2-Me, 4-Br 14848 Bu-F 2-Me, 4-SnMe, 14849 Bu-F 2-SnMe.sub.3, 4-Me 14850 Bu-F 2-Me, 4-Me 14851 Bu-F 2-Et, 4-Br 14852 Bu-F 2-Et, 4-SnMe, 14853 Bu-F 2-Et, 4-Me 14854 Bu-F 2-Me, 4-Me, 6-Me 14855 Bu-F 2-Me, 4-Br, 6-Me 14856 Bu-F 2-Me, 4-SnMe.sub.3, 6-Me 14857 Bu-F 2-Et, 6-Me 14858 Bu-F 2-Br, 4-i-Pr 14859 Bu-F 2-SnMe.sub.3, 4-i-Pr 14860 Bu-F 2-Me, 4-i-Pr 14861 Bu-F 2-Br, 4-Br, 6-Br 14862 Bu-F 2-Br, 4-Me, 6-Br 14863 Bu-F 2-Br, 4-SnMe.sub.3, 6-Br 14864 Bu-F 2-SnMe.sub.3, 4-Br, 6-Br 14865 Bu-F 2-Br, 4-Br, 6-Me 14866 Bu-F 2-Br, 4-CF.sub.3, 6-Br 14867 Bu-F 2-Br, 4-Br, 6-CF.sub.3 14868 Bu-F 2-CF.sub.3, 4-CF.sub.3 14869 Bu-F 2-Cl, 4-CF.sub.3 14870 Bu-F 2-CF.sub.3, 4-Cl 14871 Bu-F 2-Br, 4-CF, 3 14872 Bu-F 2-SnMe.sub.3, 4-CF.sub.3 14873 Bu-F 2-Me, 4-CF.sub.3 14874 Bu-F 2-CF.sub.3, 4-Br 14875 Bu-F 2-CF.sub.3, 4-SaMe.sub.3 14876 Bu-F 2-CF.sub.3, 4-Me 14877 Bu-F 2-Br, 4-OH 14878 Bu-F 2-Br, 4-OMe 14879 Bu-F 2-Br, 4-OMeF 14880 Bu-F 2-Br, 4-OCF.sub.3 14881 Bu-F 2-Br, 4-OEtF 14882 Bu-F 2-Br, 4-OPrF 14883 Bu-F 2-OH, 4-Br 14884 Bu-F 2-OMe, 4-Br 14885 Bu-F 2-OMeF, 4-Br 14886 Bu-F 2-OCF.sub.3, 4-Br 14887 Bu-F 2-OEtF, 4-Br 14888 Bu-F 2-OPrF, 4-Br 14889 Bu-F 2-I, 4-OH 14890 Bu-F 2-I, 4-OMe 14891 Bu-F 2-I, 4-OMeF 14892 Bu-F 2-I, 4-OCF.sub.3 14893 Bu-F 2-I, 4-OEtF 14894 Bu-F 2-I, 4-OPrF 14895 Bu-F 2-OH, 4-I 14896 Bu-F 2-OMe, 4-I 14897 Bu-F 2-OMeF, 4-I 14898 Bu-F 2-OCF.sub.3, 4-I 14899 Bu-F 2-OEtF, 4-I 14900 Bu-F 2-OPrF, 4-I

14901 Bu-F 2-SnMe.sub.3, 4-OH 14902 Bu-F 2-SnMe.sub.3, 4-OMe 14903 Bu-F 2-SnMe.sub.3, 4-OMeF 14904 Bu-F 2-SnMe.sub.3, 4-OCF.sub.3 14905 Bu-F 2-SnMe.sub.3, 4-OEtF 14906 Bu-F 2-SnMe.sub.3, 4-OPrF 14907 Bu-F 2-OH, 4-SnMe.sub.3 14908 Bu-F 2-OMe, 4-SnMe.sub.3 14909 Bu-F 2-OMeF, 4-SnMe.sub.3 14910 Bu-F 2-OCF.sub.3, 4-SnMe.sub.3 14911 Bu-F 2-OEtF, 4-SnMe.sub.3 14912 Bu-F 2-OPrF, 4-SnMe.sub.3 14913 Pr H 14914 Pr 2-t-Bu 14915 Pr 2-Br 14916 Pr 3-Br 14917 Pr 4-Br 14918 Pr 2-I 14919 Pr 3-I 14920 Pr 4-I 14921 Pr 2-SnMe.sub.3 14922 Pr 3-SnMe.sub.3 14923 Pr 4-SnMe.sub.3 14924 Pr 2-Me 14925 Pr 3-Me 14926 Pr 4-Me 14927 Pr 2-OH 14928 Pr 3-OH 14929 Pr 4-OH 14930 Pr 2-OMe 14931 Pr 3-OMe 14932 Pr 4-OMe 14933 Pr 2-OMeF 14934 Pr 3-OMeF 14935 Pr 4-OMeF 14936 Pr 2-OCF.sub.3 14937 Pr 3-OCF.sub.3 14938 Pr 4-OCF.sub.3 14939 Pr 2-OEtF 14940 Pr 3-OEtF 14941 Pr 4-OEtF 14942 Pr 2-OPrF 14943 Pr 3-OPrF 14944 Pr 4-OPrF 14945 Pr 2-SH 14946 Pr 3-SH 14947 Pr 4-SH 14948 Pr 2-SMe 14949 Pr 3-SMe 14950 Pr 4-SMe 14951 Pr 2-SMeF 14952 Pr 3-SMeF 14953 Pr 4-SMeF 14954 Pr 2-SCF.sub.3 14955 Pr 3-SCF.sub.3 14956 Pr 4-SCF.sub.3 14957 Pr 2-SEtF 14958 Pr 3-SEtF 14959 Pr 4-SEtF 14960 Pr 2-SPrF 14961 Pr 3-SPrF 14962 Pr 4-SPrF 14963 Pr 2-OMe, 4-OMe 14964 Pr 2-Me, 5-OH 14965 Pr 2-Me, 5-OMe 14966 Pr 2-Me, 5-OMeF 14967 Pr 2-Me, 5-OEtF 14968 Pr 2-Me, 5-OPrF 14969 Pr 2-Me, 4-OH 14970 Pr 2-Me, 4-OMe 14971 Pr 2-Me, 4-OMeF 14972 Pr 2-Me, 4-OCF.sub.3 14973 Pr 2-Me, 4-OEtF 14974 Pr 2-Me, 4-OPrF 14975 Pr 2-OH, 4-Me 14976 Pr 2-OMe, 4-Me 14977 Pr 2-OMeF, 4-Me 14978 Pr 2-OCF.sub.3, 4-Me 14979 Pr 2-OEtF, 4-Me 14980 Pr 2-OPrF, 4-Me 14981 Pr 2-Cl, 4-OH 14982 Pr 2-Cl, 4-OMe 14983 Pr 2-Cl, 4-OMeF 14984 Pr 2-Cl, 4-OCF.sub.3 14985 Pr 2-Cl, 4-OEtF 14986 Pr 2-Cl, 4-OPrF 14987 Pr 2-F, 4-F 14988 Pr 2-Cl, 4-Cl 14989 Pr 2-Cl, 4-F 14990 Pr 2-Cl, 4-NO.sub.2 14991 Pr 2-Cl, 4-NH.sub.2 14992 Pr 2-Cl, 4-NHMe 14993 Pr 2-Cl, 4-NMe.sub.2 14994 Pr 2-Cl, 4-NMe.sub.3OTf 14995 Pr 2-Cl, 4-NMe.sub.3I 14996 Pr 2-Cl, 5-F 14997 Pr 2-Cl, 5-NO.sub.2 14998 Pr 2-Cl, 5-NH.sub.2 14999 Pr 2-Cl, 5-NHMe 15000 Pr 2-Cl, 5-NMe.sub.2 15001 Pr 2-Cl, 5-NMe.sub.3OTf 15002 Pr 2-Cl, 5- NMe.sub.3I 15003 Pr 2-F, 4-Cl 15004 Pr 2-NO.sub.2, 4-Cl 15005 Pr 2-NH.sub.2, 4-Cl 15006 Pr 2-NHMe, 4-Cl 15007 Pr 2-NMe.sub.2, 4-Cl 15008 Pr 2-NMe.sub.3OTf, 4-Cl 15009 Pr 2-NMe.sub.3I, 4-Cl 15010 Pr 2-F, 5-Cl 15011 Pr 2-NO.sub.2, 5-Cl 15012 Pr 2-N1-12, 5-Cl 15013 Pr 2-NHMe, 5-Cl 15014 Pr 2-NMe.sub.2, 5-Cl 15015 Pr 2-NMe.sub.3OTf, 5-Cl 15016 Pr 2-NMe.sub.3I, 5-Cl 15017 Pr 2-Br, 4-F 15018 Pr 2-Br, 4-NO.sub.2 15019 Pr 2-Br, 4-NH.sub.2 15020 Pr 2-Br, 4-NHMe 15021 Pr 2-Br, 4-NMe.sub.2 15022 Pr 2-Br, 4-NMe.sub.3OTf 15023 Pr 2-Br, 4-NMe.sub.3I 15024 Pr 2-Br, 5-F 15025 Pr 2-Br, 5-NO.sub.2 15026 Pr 2-Br, 5-NH.sub.2 15027 Pr 2-Br, 5-NHMe 15028 Pr 2-Br, 5-NMe.sub.2 15029 Pr 2-Br, 5-NMe.sub.3OTf 15030 Pr 2-Br, 5-NMe.sub.3I 15031 Pr 2-F, 4-Br 15032 Pr 2-NO.sub.2, 4-Br 15033 Pr 2-NH.sub.2, 4-Br 15034 Pr 2-NHMe, 4-Br 15035 Pr 2-NMe.sub.2, 4-Br 15036 Pr 2-NMe.sub.3OTf, 4-Br 15037 Pr 2-NMe.sub.3I, 4-Br 15038 Pr 2-I, 4-F 15039 Pr 2-I, 4-NO.sub.2 15040 Pr 2-I, 4-NH.sub.2 15041 Pr 2-I, 4-NHMe 15042 Pr 2-I, 4-NMe.sub.2 15043 Pr 2-I, 4-NMe.sub.3OTf 15044 Pr 2-I, 4-NMe.sub.3I 15045 Pr 2-F, 4-I 15046 Pr 2-NO.sub.2, 4-I 15047 Pr 2-NH.sub.2, 4-I 15048 Pr 2-NHMe, 4-I 15049 Pr 2-NMe.sub.2, 4-I 15050 Pr 2-NMe.sub.3OTf, 4-I 15051 Pr 2-NMe.sub.3I, 4-I 15052 Pr 2-Me, 3-F 15053 Pr 2-Me, 3-NO.sub.2 15054 Pr 2-Me, 3-NH.sub.2 15055 Pr 2-Me, 3-NHMe 15056 Pr 2-Me, 3-NMe.sub.2 15057 Pr 2-Me, 3-NMe.sub.3OTf 15058 Pr 2-Me, 3-NMe.sub.3I 15059 Pr 2-Me, 4-F 15060 Pr 2-Me, 4-NO.sub.2 15061 Pr 2-Me, 4-NH.sub.2 15062 Pr 2-Me, 4-NHMe 15063 Pr 2-Me, 4-NMe.sub.2 15064 Pr 2-Me, 4-NMe.sub.3OTf 15065 Pr 2-Me, 4-NMe.sub.3I 15066 Pr 2-Me, 5-F 15067 Pr 2-Me, 5-NO.sub.2 15068 Pr 2-Me, 5-NH.sub.2 15069 Pr 2-Me, 5-NHMe 15070 Pr 2-Me, 5-NMe.sub.2 15071 Pr 2-Me, 5-NMe.sub.3OTf 15072 Pr 2-Me, 5-NMe.sub.3I 15073 Pr 2-F, 4-Me 15074 Pr 2-NO.sub.2, 4-Me 15075 Pr 2-NH.sub.2, 4-Me 15076 Pr 2-NHMe, 4-Me 15077 Pr 2-NMe.sub.2, 4-Me 15078 Pr 2-NMe.sub.3, 4-Me 15079 Pr 2-NMe.sub.3OTf, 4-Me 15080 Pr 2-NMe.sub.3I, 4-Me 15081 Pr 2-SnMe.sub.3, 4-F 15082 Pr 2-SnMe.sub.3, 5-F 15083 Pr 2-F, 4-SnMe.sub.3 15084 Pr 2-Br, 6-Cl, 4-F 15085 Pr 2-Br, 6-Cl, 4-NO.sub.2 15086 Pr 2-Br, 6-Cl, 4-NH.sub.2 15087 Pr 2-Br, 6-Cl, 4-NHMe 15088 Pr 2-Br, 6-Cl, 4-NMe.sub.2 15089 Pr 2-Br, 6-Cl, 4-NMe.sub.3OTf 15090 Pr 2-Br, 6-Cl, 4-NMe.sub.3I 15091 Pr 2-Me, 6-Cl, 4-F 15092 Pr 2-SnMe.sub.3, 6-Cl, 4-F 15093 Pr 2-Cl, 4-Me 15094 Pr 2-Cl, 4-Br 15095 Pr 2-Cl, 4-SnMe.sub.3 15096 Pr 2-Br, 4-Cl 15097 Pr 2-SnMe.sub.3, 4-Cl 15098 Pr 2-Me, 4-Cl 15099 Pr 2-Br, 4-Br 15100 Pr 2-Br, 4-Me 15101 Pr 2-Br, 4-SnMe.sub.3 15102 Pr 2-SnMe.sub.3, 4-Br 15103 Pr 2-Me, 4-Br 15104 Pr 2-Me, 4-SnMe.sub.3 15105 Pr 2-SnMe.sub.3, 4-Me 15106 Pr 2-Me, 4-Me 15107 Pr 2-Et, 4-Br 15108 Pr 2-Et, 4-SnMe.sub.3 15109 Pr 2-Et, 4-Me 15110 Pr 2-Me, 4-Me, 6-Me 15111 Pr 2-Me, 4-Br, 6-Me 15112 Pr 2-Me, 4-SnMe.sub.3, 6-Me 15113 Pr 2-Et, 6-Me 15114 Pr 2-Br, 4-i-Pr 15115 Pr 2-SnMe.sub.3, 4-i-Pr 15116 Pr 2-Me, 4-i-Pr 15117 Pr 2-Br, 4-Br, 6-Br 15118 Pr 2-Br, 4-Me, 6-Br 15119 Pr 2-Br, 4-SnMe.sub.3, 6-Br 15120 Pr 2-SnMe.sub.3, 4-Br, 6-Br 15121 Pr 2-Br, 4-Br, 6-Me 15122 Pr 2-Br, 4-CF.sub.3, 6-Br 15123 Pr 2-Br, 4-Br, 6-CF.sub.3 15124 Pr 2-CF.sub.3, 4-CF.sub.3 15125 Pr 2-Cl, 4-CF.sub.3 15126 Pr 2-CF.sub.3, 4-Cl 15127 Pr 2-Br, 4-CF.sub.3 15128 Pr 2-SnMe.sub.3, 4-CF.sub.3 15129 Pr 2-Me, 4-CF.sub.3 15130 Pr 2-CF.sub.3, 4-Br 15131 Pr 2-CF.sub.3, 4-SnMe.sub.3 15132 Pr 2-CF.sub.3, 4-Me 15133 Pr 2-Br, 4-OH 15134 Pr 2-Br, 4-OMe 15135 Pr 2-Br, 4-OMeF 15136 Pr 2-Br, 4-OCF.sub.3 15137 Pr 2-Br, 4-OEtF 15138 Pr 2-Br, 4-OPrF 15139 Pr 2-OH, 4-Br 15140 Pr 2-OMe, 4-Br 15141 Pr 2-OMeF, 4-Br 15142 Pr 2-OCF.sub.3, 4-Br 15143 Pr 2-OEtF, 4-Br 15144 Pr 2-OPrF, 4-Br 15145 Pr 2-I, 4-OH 15146 Pr 2-I, 4-OMe 15147 Pr 2-I, 4-OMeF 15148 Pr 2-I, 4-OCF.sub.3 15149 Pr 2-I, 4-OEtF 15150 Pr 2-I, 4-OPrF 15151 Pr 2-OH, 4-I

15152 Pr 2-OMe, 4-I 15153 Pr 2-OMeF, 4-I 15154 Pr 2-OMeF, 4-I 15155 Pr 2-OEtF, 4-I 15156 Pr 2-OPrF, 4-I 15157 Pr 2-SnMe.sub.3, 4-OH 15158 Pr 2-SnMe.sub.3, 4-OMe 15159 Pr 2-SnMe.sub.3, 4-OMeF 15160 Pr 2-SnMe.sub.3, 4-OCF.sub.3 15161 Pr 2-SnMe.sub.3, 4-OEtF 15162 Pr 2-SnMe.sub.3, 4-OPrF 15163 Pr 2-OH, 4-SnMe.sub.3 15164 Pr 2-OMe, 4-SnMe.sub.3 15165 Pr 2-OMeF, 4-SnMe.sub.3 15166 Pr 2-OCF.sub.3, 4-SnMe.sub.3 15167 Pr 2-OEtF, 4-SnMe.sub.3 15168 Pr 2-OPrF, 4-SnMe.sub.3 15169 Pr-F H 15170 Pr-F 2-t-Bu 15171 Pr-F 2-Br 15172 Pr-F 3-Br 15173 Pr-F 4-Br 15174 Pr-F 2-I 15175 Pr-F 3-I 15176 Pr-F 4-I 15177 Pr-F 2-SnMe.sub.3 15178 Pr-F 3-SnMe.sub.3 15179 Pr-F 4-SnMe.sub.3 15180 Pr-F 2-Me 15181 Pr-F 3-Me 15182 Pr-F 4-Me 15183 Pr-F 2-OH 15184 Pr-F 3-OH 15185 Pr-F 4-OH 15186 Pr-F 2-OMe 15187 Pr-F 3-OMe 15188 Pr-F 4-OMe 15189 Pr-F 2-OMeF 15190 Pr-F 3-OMeF 15191 Pr-F 4-OMeF 15192 Pr-F 2-OCF.sub.3 15193 Pr-F 3-OCF.sub.3 15194 Pr-F 4-OCF.sub.3 15195 Pr-F 2-OEtF 15196 Pr-F 3-OEtF 15197 Pr-F 4-OEtF 15198 Pr-F 2-OPrF 15199 Pr-F 3-OPrF 15200 Pr-F 4-OPrF 15201 Pr-F 2-SH 15202 Pr-F 3-SH 15203 Pr-F 4-SH 15204 Pr-F 2-SMe 15205 Pr-F 3-SMe 15206 Pr-F 4-SMe 15207 Pr-F 2-SMeF 15208 Pr-F 3-SMeF 15209 Pr-F 4-SMeF 15210 Pr-F 2-SCF.sub.3 15211 Pr-F 3-SCF.sub.3 15212 Pr-F 4-SCF.sub.3 15213 Pr-F 2-SEtF 15214 Pr-F 3-SEtF 15215 Pr-F 4-SEtF 15216 Pr-F 2-SPrF 15217 Pr-F 3-SPrF 15218 Pr-F 4-SPrF 15219 Pr-F 2-OMe, 4-OMe 15220 Pr-F 2-Me, 5-OH 15221 Pr-1, 2-Me, 5-OMe 15222 Pr-F 2-Me, 5-OMeF 15223 Pr-F 2-Me, 5-OEtF 15224 Pr-F 2-Me, 5-OPrF 15225 Pr-F 2-Me, 4-OH 15226 Pr-F 2-Me, 4-OMe 15227 Pr-F 2-Me, 4-OMeF 15228 Pr-F 2-Me, 4-OCF.sub.3 15229 Pr-F 2-Me, 4-OEtF 15230 Pr-F 2-Me, 4-OPrF 15231 Pr-F 2-OH, 4-Me 15232 Pr-F 2-OMe, 4-Me 15233 Pr-F 2-OMeF, 4-Me 15234 Pr-F 2-OCF.sub.3, 4-Me 15235 Pr-F 2-OEtF, 4-Me 15236 Pr-F 2-OPrF, 4-Me 15237 Pr-F 2-Cl, 4-OH 15238 Pr-F 2-Cl, 4-OMe 15239 Pr-F 2-Cl, 4-OMeF 15240 Pr-F 2-Cl, 4-OCF.sub.3 15241 Pr-F 2-Cl, 4-OEtF 15242 Pr-F 2-Cl, 4-OPrF 15243 Pr-F 2-F, 4-F 15244 Pr-F 2-Cl, 4-Cl 15245 Pr-F 2-Cl, 4-F 15246 Pr-F 2-Cl, 4-NO.sub.2 15247 Pr-F 2-Cl, 4-NH.sub.2 15248 Pr-F 2-Cl, 4-NHMe 15249 Pr-F 2-Cl, 4-NMe.sub.2 15250 Pr-F 2-Cl, 4-NMe.sub.3OTf 15251 Pr-F 2-Cl, 4-NMe.sub.3I 15252 Pr-F 2-Cl, 5-F 15253 Pr-F 2-Cl, 5-NO.sub.2 15254 Pr-F 2-Cl, 5-NH.sub.2 15255 Pr-F 2-Cl, 5-NHMe 15256 Pr-F 2-Cl, 5-NMe.sub.2 15257 Pr-F 2-Cl, 5-NMe.sub.3OTf 15258 Pr-F 2-Cl, 5-NMe.sub.3I 15259 Pr-F 2-F, 4-Cl 15260 Pr-F 2-NO.sub.2, 4-Cl 15261 Pr-F 2-NH.sub.2, 4-Cl 15262 Pr-F 2-NHMe, 4-Cl 15263 Pr-F 2-NMe.sub.2, 4-Cl 15264 Pr-F 2-NMe.sub.3OTf, 4-Cl 15265 Pr-F 2-NMe.sub.3I, 4-Cl 15266 Pr-F 2-F, 5-Cl 15267 Pr-F 2-NO.sub.2, 5-Cl 15268 Pr-F 2-NH.sub.2, 5-Cl 15269 Pr-F 2-NHMe, 5-Cl 15270 Pr-F 2-NMe.sub.2, 5-Cl 15271 Pr-F 2-NMe.sub.3OTf, 5-Cl 15272 Pr-F 2-NMe.sub.3I, 5-Cl 15273 Pr-F 2-Br, 4-F 15274 Pr-F 2-Br, 4-NO.sub.2 15275 Pr-F 2-Br, 4-NH.sub.2 15276 Pr-F 2-Br, 4-NHMe 15277 Pr-F 2-Br, 4-NMe.sub.2 15278 Pr-F 2-Br, 4-NMe.sub.3OTf 15279 Pr-F 2-Br, 4-NMe.sub.3I 15280 Pr-F 2-Br, 5-F 15281 Pr-F 2-Br, 5-NO.sub.2 15282 Pr-F 2-Br, 5-NH.sub.2 15283 Pr-F 2-Br, 5-NHMe 15284 Pr-F 2-Br, 5-NMe.sub.2 15285 Pr-F 2-Br, 5-NMe.sub.3OTf 15286 Pr-F 2-Br, 5-NMe.sub.3I 15287 Pr-F 2-F, 4-Br 15288 Pr-F 2-NO.sub.2, 4-Br 15289 Pr-F 2-NH.sub.2, 4-Br 15290 Pr-F 2-NHMe, 4-Br 15291 Pr-F 2-NMe.sub.2, 4-Br 15292 Pr-F 2-NMe.sub.3OTf, 4-Br 15293 Pr-F 2-NMe.sub.3I, 4-Br 15294 Pr-F 2-I, 4-F 15295 Pr-F 2-I, 4-NO.sub.2 15296 Pr-F 2-I, 4-NH.sub.2 15297 Pr-F 2-I, 4-NHMe 15298 Pr-F 2-I, 4-NMe.sub.2 15299 Pr-F 2-I, 4-NMe.sub.3OTf 15300 Pr-F 2-I, 4-NMe.sub.3I 15301 Pr-F 2-F, 4-I 15302 Pr-F 2-NO.sub.2, 4-I 15303 Pr-F 2-NH.sub.2, 4-I 15304 Pr-F 2-NHMe, 4-I 15305 Pr-F 2-NMe.sub.2, 4-I 15306 Pr-F 2-NMe.sub.3OTf, 4-I 15307 Pr-F 2-NMe.sub.3I, 4-I 15308 Pr-F 2-Me, 3-F 15309 Pr-F 2-Me, 3-NO.sub.2 15310 Pr-F 2-Me, 3-NH.sub.2 15311 Pr-F 2-Me, 3-NHMe 15312 Pr-F 2-Me, 3-NMe.sub.2 15313 Pr-F 2-Me, 3-NMe.sub.3OTf 15314 Pr-F 2-Me, 3-NMe.sub.3I 15315 Pr-F 2-Me, 4-F 15316 Pr-F 2-Me, 4-NO.sub.2 15317 Pr-F 2-Me, 4-NH.sub.2 15318 Pr-F 2-Me, 4-NHMe 15319 Pr-F 2-Me, 4-NMe.sub.2 15320 Pr-F 2-Me, 4-NMe.sub.3OTf 15321 Pr-F 2-Me, 4-NMe.sub.3I 15322 Pr-F 2-Me, 5-F 15323 Pr-F 2-Me, 5-NO.sub.2 15324 Pr-F 2-Me, 5-NH.sub.2 15325 Pr-F 2-Me, 5-NHMe 15326 Pr-F 2-Me, 5-NMe.sub.2 15327 Pr-F 2-Me, 5-NMe.sub.3OTf 15328 Pr-F 2-Me, 5-NMe.sub.3I 15329 Pr-F 2-F, 4-Me 15330 Pr-F 2-NO.sub.2, 4-Me 15331 Pr-F 2-NH.sub.2, 4-Me 15332 Pr-F 2-NHMe, 4-Me 15333 Pr-F 2-NMe.sub.2, 4-Me 15334 Pr-F 2-NMe.sub.3, 4-Me 15335 Pr-F 2-NMe.sub.3OTf, 4-Me 15336 Pr-F 2-NMe.sub.3I, 4-Me 15337 Pr-F 2-SnMe.sub.3, 4-F 15338 Pr-F 2-SnMe.sub.3, 5-F 15339 Pr-F 2-F, 4-SnMe.sub.3 15340 Pr-F 2-Br, 6-Cl, 4-F 15341 Pr-F 2-Br, 6-Cl, 4-NO.sub.2 15342 Pr-F 2-Br, 6-Cl, 4-NH.sub.2 15343 Pr-F 2-Br, 6-Cl, 4-NHMe 15344 Pr-F 2-Br, 6-Cl, 4-NMe, 15345 Pr-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 15346 Pr-F 2-Br, 6-Cl, 4-NMe.sub.3I 15347 Pr-F 2-Me, 6-Cl, 4-F 15348 Pr-F 2-SnMe.sub.3, 6-Cl, 4-F 15349 Pr-F 2-Cl, 4-Me 15350 Pr-F 2-Cl, 4-Br 15351 Pr-F 2-Cl, 4-SnMe.sub.3 15352 Pr-F 2-Br, 4-Cl 15353 Pr-F 2-SnMe.sub.3, 4-Cl 15354 Pr-F 2-Me, 4-Cl 15355 Pr-F 2-Br, 4-Br 15356 Pr-F 2-Br, 4-Me 15357 Pr-F 2-Br, 4-SnMe.sub.3 15358 Pr-F 2-SnMe.sub.3, 4-Br 15359 Pr-F 2-Me, 4-Br 15360 Pr-F 2-Me, 4-SnMe.sub.3 15361 Pr-F 2-SnMe.sub.3, 4-Me 15362 Pr-F 2-Me, 4-Me 15363 Pr-F 2-Et, 4-Br 15364 Pr-F 2-Et, 4-SnMe.sub.3 15365 Pr-F 2-Et, 4-Me 15366 Pr-F 2-Me, 4-Me, 6-Me 15367 Pr-F 2-Me, 4-Br, 6-Me 15368 Pr-F 2-Me, 4-SnMe.sub.3, 6-Me 15369 Pr-F 2-Et, 6-Me 15370 Pr-F 2-Br, 4-i-Pr 15371 Pr-F 2-SnMe.sub.3, 4-i-Pr 15372 Pr-F 2-Me, 4-i-Pr 15373 Pr-F 2-Br, 4-Br, 6-Br 15374 Pr-F 2-Br, 4-Me, 6-Br 15375 Pr-F 2-Br, 4-SnMe.sub.3, 6-Br 15376 Pr-F 2-SnMe.sub.3, 4-Br, 6-Br 15377 Pr-F 2-Br, 4-Br, 6-Me 15378 Pr-F 2-Br, 4-CF.sub.3, 6-Br 15379 Pr-F 2-Br, 4-Br, 6-CF.sub.3 15380 Pr-F 2-CF.sub.3, 4-CF.sub.3 15381 Pr-F 2-Cl, 4-CF.sub.3 15382 Pr-F 2-CF.sub.3, 4-Cl 15383 Pr-F 2-Br, 4-CF.sub.3 15384 Pr-F 2-SnMe.sub.3, 4-CF.sub.3 15385 Pr-F 2-Me, 4-CF.sub.3 15386 Pr-F 2-CF.sub.3, 4-Br 15387 Pr-F 2-CF.sub.3, 4-SnMe.sub.3 15388 Pr-F 2-CF.sub.3, 4-Me 15389 Pr-F 2-Br, 4-OH 15390 Pr-F 2-Br, 4-OMe 15391 Pr-F 2-Br, 4-OMeF 15392 Pr-F 2-Br, 4-OCF.sub.3 15393 Pr-F 2-Br, 4-OEtF 15394 Pr-F 2-Br, 4-OPrF 15395 Pr-F 2-OH, 4-Br 15396 Pr-F 2-OMe, 4-Br 15397 Pr-F 2-OMeF, 4-Br 15398 Pr-F 2-OCF.sub.3, 4-Br 15399 Pr-F 2-OEtF, 4-Br 15400 Pr-F 2-OPrF, 4-Br 15401 Pr-F 2-I, 4-OH 15402 Pr-F 2-I, 4-OMe

15403 Pr-F 2-I, 4-OMeF 15404 Pr-F 2-I, 4-OCF.sub.3 15405 Pr-F 2-I, 4-OEtF 15406 Pr-F 2-I, 4-OPrF 15407 Pr-F 2-OH, 4-I 15408 Pr-F 2-OMe, 4-I 15409 Pr-F 2-OMeF, 4-I 15410 Pr-F 2-OCF.sub.3, 4-I 15411 Pr-F 2-OEtF, 4-I 15412 Pr-F 2-OPrF, 4-I 15413 Pr-F 2-SnMe.sub.3, 4-OH 15414 Pr-F 2-SnMe.sub.3, 4-OMe 15415 Pr-F 2-SnMe.sub.3, 4-OMeF 15416 Pr-F 2-SnMe.sub.3, 4-OCF.sub.3 15417 Pr-F 2-SnMe.sub.3, 4-OEtF 15418 Pr-F 2-SnMe.sub.3, 4-OPrF 15419 Pr-F 2-OH, 4-SnMe.sub.3 15420 Pr-F 2-OMe, 4-SnMe.sub.3 15421 Pr-F 2-OMeF, 4-SnMe.sub.3 15422 Pr-F 2-OCF.sub.3, 4-SnMe.sub.3 15423 Pr-F 2-OEtF, 4-SnMe.sub.3 15424 Pr-F 2-OPrF, 4-SnMe.sub.3 15425 Et H 15426 Et 2-t-Bu 15427 Et 2-Br 15428 Et 3-Br 15429 Et 4-Br 15430 Et 2-I 15431 Et 3-I 15432 Et 4-I 15433 Et 2-SnMe.sub.3 15434 Et 3-SnMe.sub.3 15435 Et 4-SnMe.sub.3 15436 Et 2-Me 15437 Et 3-Me 15438 Et 4-Me 15439 Et 2-OH 15440 Et 3-OH 15441 Et 4-OH 15442 Et 2-OMe 15443 Et 3-OMe 15144 Et 4-OMe 15445 Et 2-OMeF 15446 Et 3-OMeF 15447 Et 4-OMeF 15448 Et 2-OCF.sub.3 15449 Et 3-OCF.sub.3 15450 Et 4-OCF.sub.3 15451 Et 2-OEtF 15452 Et 3-OEtF 15453 Et 4-OEtF 15454 Et 2-OPrF 15455 Et 3-OPrF 15456 Et 4-OPrF 15457 Et 2-SH 15458 Et 3-SH 15459 Et 4-SH 15460 Et 2-SMe 15461 Et 3-SMe 15462 Et 4-SMe 15463 Et 2-SMeF 15464 Et 3-SMeF 15465 Et 4-SMeF 15466 Et 2-SCF.sub.3 15467 Et 3-SCF.sub.3 15468 Et 4-SCF.sub.3 15469 Et 2-SEtF 15470 Et 3-SEtF 15471 Et 4-SEtF 15472 Et 2-SPrF 15473 Et 3-SPrF 15474 Et 4-SPrF 15475 Et 2-OMe, 4-OMe 15476 Et 2-Me, 5-OH 15477 Et 2-Me, 5-OMe 15478 Et 2-Me, 5-OMeF 15479 Et 2-Me, 5-OEtF 15480 Et 2-Me, 5-OPrF 15481 Et 2-Me, 4-OH 15482 Et 2-Me, 4-OMe 15483 Et 2-Me, 4-OMeF 15484 Et 2-Me, 4-OCF.sub.3 15485 Et 2-Me, 4-OEtF 15486 Et 2-Me, 4-OPrF 15487 Et 2-OH, 4-Me 15488 Et 2-OMe, 4-Me 15489 Et 2-OMeE, 4-Me 15490 Et 2-OCF.sub.3, 4-Me 15491 Et 2-OEtF, 4-Me 15492 Et 2-OPrF, 4-Me 15493 Et 2-Cl, 4-OH 15494 Et 2-Cl, 4-OMe 15495 Et 2-Cl, 4-OMeF 15496 Et 2-Cl, 4-OCF.sub.3 15497 Et 2-Cl, 4-OEtF 15498 Et 2-Cl, 4-OPrF 15499 Et 2-F, 4-F 15500 Et 2-Cl, 4-Cl 15501 Et 2-Cl, 4-F 15502 Et 2-Cl, 4-NO.sub.2 15503 Et 2-Cl, 4-NH.sub.2 15504 Et 2-Cl, 4-NHMe 15505 Et 2-Cl, 4-NMe.sub.2 15506 Et 2-Cl, 4-NMe.sub.3OTf 15507 Et 2-Cl, 4-NMe.sub.3I 15508 Et 2-Cl, 5-F 15509 Et 2-Cl, 5-NO.sub.2 15510 Et 2-Cl, 5-NH.sub.2 15511 Et 2-Cl, 5-NHMe 15512 Et 2-Cl, 5-NMe.sub.2 15513 Et 2-Cl, 5-NMe.sub.3OTf 15514 Et 2-Cl, 5-NMe.sub.3I 15515 Et 2-F, 4-Cl 15516 Et 2-NO.sub.2, 4-Cl 15517 Et 2-NH.sub.2, 4-Cl 15518 Et 2-NHMe, 4-Cl 15519 El 2-NMe.sub.2, 4-Cl 15520 Et 2-NMe.sub.3OTf, 4-Cl 15521 Et 2-NMe.sub.3I, 4-Cl 15522 Et 2-F, 5-Cl 15523 Et 2-NO.sub.2, 5-Cl 15524 Et 2-NH.sub.2, 5-Cl 15525 Et 2-NHMe, 5-Cl 15526 Et 2-NMe.sub.2, 5-Cl 15527 Et 2-NMe.sub.3OTf, 5-Cl 15528 Et 2-NMe.sub.3I, 5-Cl 15529 Et 2-Br, 4-F 15530 Et 2-Br, 4-NO.sub.2 15531 Et 2-Br, 4-NH.sub.2 15532 Et 2-Br, 4-NHMe 15533 Et 2-Br, 4-NMe.sub.2 15534 Et 2-Br, 4-NMe.sub.3OTf 15535 Et 2-Br, 4-NMe.sub.3I 15536 Et 2-Br, 5-F 15537 Et 2-Br, 5-NO.sub.2 15538 Et 2-Br, 5-NH.sub.2 15539 Et 2-Br, 5-NHMe 15540 Et 2-Br, 5-NMe.sub.2 15541 Et 2-Br, 5-NMe.sub.3OTf 15542 Et 2-Br, 5-NMe.sub.3I 15543 Et 2-F, 4-Br 15544 Et 2-NO.sub.2, 4-Br 15545 Et 2-NH.sub.2, 4-Br 15546 Et 2-NHMe, 4-Br 15547 Et 2-NMe.sub.2, 4-Br 15548 Et 2-NMe.sub.3OTf, 4-Br 15549 Et 2-NMe.sub.3I, 4-Br 15550 Et 2-I, 4-F 15551 Et 2-I, 4-NO.sub.2 15552 Et 2-I, 4-NH.sub.2 15553 Et 2-I, 4-NHMe 15554 Et 2-I, 4-NMe.sub.2 15555 Et 2-I, 4-NMe.sub.3OTf 15556 Et 2-I, 4-NMe.sub.3I 15557 Et 2-F, 4-I 15558 Et 2-NO.sub.2, 4-I 15559 Et 2-NH.sub.2, 4-I 15560 Et 2-NHMe, 4-I 15561 Et 2-NMe.sub.2, 4-I 15562 Et 2-NMe.sub.3OTf, 4-I 15563 Et 2-NMe.sub.3I, 4-I 15564 Et 2-Me, 3-F 15565 Et 2-Me, 3-NO.sub.2 15566 Et 2-Me, 3-NH.sub.2 15567 Et 2-Me, 3-NHMe 15568 Et 2-Me, 3-NMe.sub.2 15569 Et 2-Me, 3-NMe.sub.3OTf 15570 Et 2-Me, 3-NMe.sub.3I 15571 Et 2-Me, 4-F 15572 Et 2-Me, 4-NO.sub.2 15573 Et 2-Me, 4-NH.sub.2 15574 Et 2-Me, 4-NHMe 15575 Et 2-Me, 4-NMe.sub.2 15576 Et 2-Me, 4-NMe.sub.3OTf 15577 Et 2-Me, 4-NMe.sub.3I 15578 Et 2-Me, 5-F 15579 Et 2-Me, 5-NO.sub.2 15580 Et 2-Me, 5-NH.sub.2 15581 Et 2-Me, 5-NHMe 15582 Et 2-Me, 5-NMe.sub.2 15583 Et 2-Me, 5-NMe.sub.3OTf 15584 Et 2-Me, 5-NMe.sub.3I 15585 Et 2-F, 4-Me 15586 Et 2-NO.sub.2, 4-Me 15587 Et 2-NH.sub.2, 4-Me 15588 Et 2-NHMe, 4-Me 15589 Et 2-NMe.sub.2, 4-Me 15590 Et 2-NMe.sub.3, 4-Me 15591 Et 2-NMe.sub.3OTf, 4-Me 15592 Et 2-NMe.sub.3I, 4-Me 15593 Et 2-SnMe.sub.3, 4-F 15594 Et 2-SnMe.sub.3, 5-F 15595 Et 2-F, 4-SnMe.sub.3 15596 Et 2-Br, 6-Cl, 4-F 15597 Et 2-Br, 6-Cl, 4-NO.sub.2 15598 Et 2-Br, 6-Cl, 4-NH.sub.2 15599 Et 2-Br, 6-Cl, 4-NHMe 15600 Et 2-Br, 6-Cl, 4-NMe.sub.2 15601 Et 2-Br, 6-Cl, 4-NMe.sub.3OTf 15602 Et 2-Br, 6-Cl, 4-NMe.sub.3I 15603 Et 2-Me, 6-Cl, 4-F 15604 Et 2-SnMe.sub.3, 6-Cl, 4-F 15605 Et 2-Cl, 4-Me 15606 Et 2-Cl, 4-Br 15607 Et 2-Cl, 4-SnMe.sub.3 15608 Et 2-Br, 4-Cl 15609 Et 2-SnMe.sub.3, 4-Cl 15610 Et 2-Me, 4-Cl 15611 Et 2-Br, 4-Br 15612 Et 2-Br, 4-Me 15613 Et 2-Br, 4-SnMe.sub.3 15614 Et 2-SnMe.sub.3, 4-Br 15615 Et 2-Me, 4-Br 15616 Et 2-Me, 4-SnMe.sub.3 15617 Et 2-SnMe.sub.3, 4-Me 15618 Et 2-Me, 4-Me 15619 Et 2-Et, 4-Br 15620 Et 2-Et, 4-SnMe.sub.3 15621 Et 2-Et, 4-Me 15622 Et 2-Me, 4-Me, 6-Me 15623 Et 2-Me, 4-Br, 6-Me 15624 Et 2-Me, 4-SnMe.sub.3, 6-Me 15625 Et 2-Et, 6-Me 15626 Et 2-Br, 4-i-Pr 15627 Et 2-SnMe.sub.3, 4-i-Pr 15628 Et 2-Me, 4-i-Pr 15629 Et 2-Br, 4-Br, 6-Br 15630 Et 2-Br, 4-Me, 6-Br 15631 Et 2-Br, 4-SnMe.sub.3, 6-Br 15632 Et 2-SnMe.sub.3, 4-Br, 6-Br 15633 Et 2-Br, 4-Br, 6-Me 11634 Et 2-Br, 4-CF.sub.3, 6-Br 15635 Et 2-Br, 4-Br, 6-CF.sub.3 15636 Et 2-CF.sub.3, 4-CF.sub.3 15637 Et 2-Cl, 4-CF.sub.3 15638 Et 2-CF.sub.3, 4-Cl 15639 Et 2-Br, 4-CF.sub.3 15640 Et 2-SnMe.sub.3, 4-CF.sub.3 15641 Et 2-Me, 4-CF.sub.3 15642 Et 2-CF.sub.3, 4-Br 15643 Et 2-CF.sub.3, 4-SnMe.sub.3 15644 Et 2-CF.sub.3, 4-Me 15645 Et 2-Br, 4-OH 15646 Et 2-Br, 4-OMe 15647 Et 2-Br, 4-OMeF 15648 Et 2-Br, 4-OCF.sub.3 15649 Et 2-Br, 4-OEtF 15650 Et 2-Br, 4-OPrF 15651 Et 2-OH, 4-Br 15652 Et 2-OMe, 4-Br 15653 Et 2-OMeF, 4-Br

15654 Et 2-OCF.sub.3, 4-Br 15655 Et 2-OEtF, 4-Br 15656 Et 2-OPrF, 4-Br 15657 Et 2-I, 4-OH 15658 Et 2-I, 4-OMe 15659 Et 2-I, 4-OMeF 15660 Et 2-I, 4-OCF.sub.3 15661 Et 2-I, 4-OEtF 15662 Et 2-I, 4-OPrF 15663 Et 2-OH, 4-I 15664 Et 2-OMe, 4-I 15665 Et 2-OMeF, 4-I 15666 Et 2-OCF.sub.3, 4-I 15667 Et 2-OEtF, 4-I 15668 Et 2-OPrF, 4-I 15669 Et 2-SnMe.sub.3, 4-OH 15670 Et 2-SnMe.sub.3, 4-OMe 15671 Et 2-SnMe.sub.3, 4-OMeF 15672 Et 2-SnMe.sub.3, 4-OCF.sub.3 15673 Et 2-SnMe.sub.3, 4-OEtF 15674 Et 2-SnMe.sub.3, 4-OPrF 15675 Et 2-OH, 4-SnMe.sub.3 15676 Et 2-OMe, 4-SnMe.sub.3 15677 Et 2-OMeF, 4-SnMe.sub.3 15678 Et 2-OCF.sub.3, 4-SnMe.sub.3 15679 Et 2-OEtF, 4-SnMe.sub.3 15680 Et 2-OPrF, 4-SnMe.sub.3 15681 Et-F H 15682 Et-F 2-t-Bu 15683 Et-F 2-Br 15684 Et-F 3-Br 15685 Et-F 4-Br 15686 Et-F 2-I 15687 Et-F 3-I 15688 Et-F 4-I 15689 Et-F 2-SnMe.sub.3 15690 Et-F 3-SnMe.sub.3 15691 Et-F 4-SnMe.sub.3 15692 Et-F 2-Me 15693 Et-F 3-Me 15694 Et-F 4-Me 15695 Et-F 2-OH 15696 Et-F 3-OH 15697 Et-F 4-OH 15698 Et-F 2-OMe 15699 Et-F 3 -OMe 15700 Et-F 4-OMe 15701 Et-F 2-OMeF 15702 Et-F 3-OMeF 15703 Et-F 4-OMeF 15704 Et-F 2-OCF.sub.3 15705 Et-F 3-OCF.sub.3 15706 Et-F 4-OCF.sub.3 15707 Et-F 2-OEtF 15708 Et-F 3-OEtF 15709 Et-F 4-OEtF 15710 Et-F 2-OPrF 15711 Et-F 3-OPrF 15712 Et-F 4-OPrF 15713 Et-F 2-SH 15714 Et-F 3-SH 15715 Et-F 4-SH 15716 Et-F 2-SMe 15717 Et-F 3-SMe 15718 Et-F 4-SMe 15719 Et-F 2-SMeF 15720 Et-F 3-SMeF 15721 Et-F 4-SMeF 15722 Et-F 2-SCF.sub.3 15723 Et-F 3-SCF.sub.3 15724 Et-F 4-SCF.sub.3 15725 Et-F 2-SEtF 15726 Et-F 3-SEtF 15727 Et-F 4-SEtF 15728 Et-F 2-SPrF 15729 Et-F 3-SPrF 15730 Et-F 4-SPrF 15731 Et-F 2-OMe, 4-OMe 15732 Et-F 2-Me, 5-OH 15733 Et-F 2-Me, 5-OMe 15734 Et-F 2-Me, 5-OMeF 15735 Et-F 2-Me, 5-OEtF 15736 Et-F 2-Me, 5-OPrF 15737 Et-F 2-Me, 4-OH 15738 Et-F 2-Me, 4-OMe 15739 Et-F 2-Me, 4-OMeF 15740 Et-F 2-Me, 4-OCF.sub.3 15741 Et-F 2-Me, 4-OEtF 15742 Et-F 2-Me, 4-OPrF 15743 Et-F 2-OH, 4-Me 15744 Et-F 2-OMe, 4-Me 15745 Et-F 2-OMeF, 4-Me 15746 Et-F 2-OCF.sub.3, 4-Me 15747 Et-F 2-OEtF, 4-Me 15748 Et-F 2-OPrF, 4-Me 15749 Et-F 2-Cl, 4-OH 15750 Et-F 2-Cl, 4-OMe 15751 Et-F 2-Cl, 4-OMeF 15752 Et-F 2-Cl, 4-OCF.sub.3 15753 Et-F 2-Cl, 4-OEtF 15754 Et-F 2-Cl, 4-OPrF 15755 Et-F 2-F, 4-F 15756 Et-F 2-Cl, 4-Cl 15757 Et-F 2-Cl, 4-F 15758 Et-F 2-Cl, 4-NO.sub.2 15759 Et-F 2-Cl, 4-NH.sub.2 15760 Et-F 2-Cl, 4-NHMe 15761 Et-F 2-Cl, 4-NMe.sub.2 15762 Et-F 2-Cl, 4-NMe.sub.3OTf 15763 Et-F 2-Cl, 4-NMe.sub.3I 15764 Et-F 2-Cl, 5-F 15765 Et-F 2-Cl, 5-NO.sub.2 11766 Et-F 2-Cl, 5-NH.sub.2 15767 Et-F 2-Cl, 5-NHMe 15768 Et-F 2-Cl, 5-NMe.sub.2 15769 Et-F 2-Cl, 5-NMe.sub.3OTf 15770 Et-F 2-Cl, 5- NMe.sub.3I 15771 Et-F 2-F, 4-Cl 15772 Et-F 2-NO.sub.2, 4-Cl 15773 Et-F 2-NH.sub.2, 4-Cl 15774 Et-F 2-NTIMe, 4-Cl 15775 Et-F 2-NMe.sub.2, 4-Cl 15776 Et-F 2-NMe.sub.3OTf, 4-Cl 15777 Et-F 2-NMe.sub.3I, 4-Cl 15778 Et-F 2-F, 5-Cl 15779 Et-F 2-NO.sub.2, 5-Cl 15780 Et-F 2-NH.sub.2, 5-Cl 15781 Et-F 2-NHMe, 5-Cl 15782 Et-F 2-NMe.sub.2, 5-Cl 15783 Et-F 2-NMe.sub.3OTf, 5-Cl 15784 Et-F 2-NMe.sub.3I, 5-Cl 15785 Et-F 2-Br, 4-F 15786 Et-F 2-Br, 4-NO.sub.2 15787 Et-F 2-Br, 4-NH.sub.2 15788 Et-F 2-Br, 4-NHMe 15789 Et-F 2-Br, 4-NMe.sub.2 15790 Et-F 2-Br, 4-NMe.sub.3OTf 15791 Et-F 2-Br, 4-NMe.sub.3I 15792 Et-F 2-Br, 5-F 15793 Et-F 2-Br, 5-NO.sub.2 15794 Et-F 2-Br, 5-NH.sub.2 15795 Et-F 2-Br, 5-NHMe 15796 Et-F 2-Br, 5-NMe.sub.2 15797 Et-F 2-Br, 5-NMe.sub.3OTf 15798 Et-F 2-Br, 5-NMe.sub.3I 15799 Et-F 2-F, 4-Br 15800 Et-F 2-NO.sub.2, 4-Br 15801 Et-F 2-NH.sub.2, 4-Br 15802 Et-F 2-NHMe, 4-Br 15803 Et-F 2-NMe.sub.2, 4-Br 15804 Et-F 2-NMe.sub.3OTf, 4-Br 15805 Et-F 2-NMe.sub.3I, 4-Br 15806 Et-F 2-I, 4-F 15807 Et-F 2-I, 4-NO.sub.2 15808 Et-F 2-I, 4-NH.sub.2 15809 Et-F 2-I, 4-NHMe 15810 Et-F 2-I, 4-NMe.sub.2 15811 Et-F 2-I, 4-NMe.sub.3OTf 15812 Et-F 2-I, 4-NMe.sub.3I 15813 Et-F 2-F, 4-I 15814 Et-F 2-NO.sub.2, 4-I 15815 Et-F 2-NH.sub.2, 4-I 15816 Et-F 2-NHMe, 4-I 15817 Et-F 2-NMe.sub.2, 4-I 15818 Et-F 2-NMe.sub.3OTf, 4-I 15819 Et-F 2-NMe.sub.3I, 4-I 15820 Et-F 2-Me, 3-F 15821 Et-F 2-Me, 3-NO.sub.2 15822 Et-F 2-Me, 3-NH.sub.2 15823 Et-F 2-Me, 3-NHMe 15824 Et-F 2-Me, 3-NMe.sub.2 15825 Et-F 2-Me, 3-NMe.sub.3OTf 15826 Et-F 2-Me, 3-NMe.sub.3I 15827 Et-F 2-Me, 4-F 15828 Et-F 2-Me, 4-NO.sub.2 15829 Et-F 2-Me, 4-NH.sub.2 15830 Et-F 2-Me, 4-NHMe 15831 Et-F 2-Me, 4-NMe.sub.2 15832 Et-F 2-Me, 4-NMe.sub.3OTf 15833 Et-F 2-Me, 4-NMe.sub.3I 15834 Et-F 2-Me, 5-F 15835 Et-F 2-Me, 5-NO.sub.2 15836 Et-F 2-Me, 5-NH.sub.2 15837 Et-F 2-Me, 5-NHMe 15838 Et-F 2-Me, 5-NMe.sub.2 15839 Et-F 2-Me, 5-NMe.sub.3OTf 15840 Et-F 2-Me, 5-NMe.sub.3I 15841 Et-F 2-F, 4-Me 15842 Et-F 2-NO.sub.2, 4-Me 15843 Et-F 2-NH.sub.2, 4-Me 15844 Et-F 2-NHMe, 4-Me 15845 Et-F 2-NMe.sub.2, 4-Me 15846 Et-F 2-NMe.sub.3, 4-Me 15847 Et-F 2-NMe.sub.3OTf, 4-Me 15848 Et-F 2-NMe.sub.3I, 4-Me 15849 Et-F 2-SnMe.sub.3, 4-F 15850 Et-F 2-SnMe.sub.3, 5-F 15851 Et-F 2-F, 4-SnMe.sub.3 15852 Et-F 2-Br, 6-Cl, 4-F 15853 Et-F 2-Br, 6-Cl, 4-NO.sub.2 15854 Et-F 2-Br, 6-Cl, 4-NH.sub.2 15855 Et-F 2-Br, 6-Cl, 4-NHMe 15856 Ft-F 2-Br, 6-Cl, 4-NMe.sub.2 15857 Et-E 2-Br, 6-Cl, 4-NMe.sub.3OTf 15858 Et-F 2-Br, 6-Cl, 4-NMe.sub.3I 15859 Et-F 2-Me, 6-Cl, 4-F 15860 Et-F 2-SnMe.sub.3, 6-Cl, 4-F 15861 Et-F 2-Cl, 4-Me 15862 Et-F 2-Cl, 4-Br 15863 Et-F 2-Cl, 4-SnMe.sub.3 15864 Et-F 2-Br, 4-Cl 15865 Et-F 2-SnMe.sub.3, 4-Cl 15866 Et-F 2-Me, 4-Cl 15867 Et-F 2-Br, 4-Br 15868 Et-F 2-Br, 4-Me 15869 Et-F 2-Br, 4-SnMe.sub.3 15870 Et-F 2-SnMe.sub.3, 4-Br 15871 Et-F 2-Me, 4-Br 15872 Et-F 2-Me, 4-SnMe.sub.3 15873 Et-F 2-SnMe.sub.3, 4-Me 15874 Et-F 2-Me, 4-Me 15875 Et-F 2-Et, 4-Br 15876 Et-F 2-Et, 4-SnMe.sub.3 15877 Et-F 2-Et, 4-Me 15878 Et-F 2-Me, 4-Me, 6-Me 15879 Et-F 2-Me, 4-Br, 6-Me 15880 Et-F 2-Me, 4-SnMe.sub.3, 6-Me 15881 Et-F 2-Et, 6-Me 15882 Et-F 2-Br, 4-i-Pr 15883 Et-F 2-SnMe.sub.3, 4-i-Pr 15884 Et-F 2-Me, 4-i-Pr 15885 Et-F 2-Br, 4-Br, 6-Br 15886 Et-F 2-Br, 4-Me, 6-Br 15887 Et-F 2-Br, 4-SnMe.sub.3, 6-Br 15888 Et-F 2-SnMe.sub.3, 4-Br, 6-Br 15889 Et-F 2-Br, 4-Br, 6-Me 15890 Et-F 2-Br, 4-CF.sub.3, 6-Br 15891 Et-F 2-Br, 4-Br, 6-CF.sub.3 15892 Et-F 2-CF.sub.3, 4-CF.sub.3 15893 Et-F 2-Cl, 4-CF.sub.3 15894 Et-F 2-CF.sub.3, 4-Cl 15895 Et-F 2-Br, 4-CF.sub.3 15896 Et-F 2-SnMe.sub.3, 4-CF.sub.3 15897 Et-F 2-Me, 4-CF.sub.3 15898 Et-F 2-CF.sub.3, 4-Br 15899 Et-F 2-CF.sub.3, 4-SnMe.sub.3 15900 Et-F 2-CF.sub.3, 4-Me 15901 Et-F 2-Br, 4-OH 15902 Et-F 2-Br, 4-OMe 15903 Et-F 2-Br, 4-OMeF 15904 Et-F 2-Br, 4-OCF.sub.3

15905 Et-F 2-Br, 4-OEtF 15906 Et-F 2-Br, 4-OPrF 15907 Et-F 2-OH, 4-Br 15908 Et-F 2-OMe, 4-Br 15909 Et-F 2-OMeF, 4-Br 15910 Et-F 2-OCF.sub.3, 4-Br 15911 Et-F 2-OEtF, 4-Br 15912 Et-F 2-OPrF, 4-Br 15913 Et-F 2-I, 4-OH 15914 Et-F 2-I, 4-OMe 15915 Et-F 2-I, 4-OMeF 15916 Et-F 2-I, 4-OCF.sub.3 15917 Et-F 2-I, 4-OEtF 15918 Et-F 2-I, 4-OPrF 15919 Et-F 2-OH, 4-I 15920 Et-F 2-OMe, 4-I 15921 Et-F 2-OMeF, 4-I 15922 Et-F 2-OCF.sub.3, 4-I 15923 Et-F 2-OEtF, 4-I 15924 Et-F 2-OPrF, 4-I 15925 Et-F 2-SnMe.sub.3, 4-OH 15926 Et-F 2-SnMe.sub.3, 4-OMe 15927 Et-F 2-SnMe.sub.3, 4-OMeF 15928 Et-F 2-SnMe.sub.3, 4-OCF.sub.3 15929 Et-F 2-SnMe.sub.3, 4-OEtF 15930 Et-F 2-SnMe.sub.3, 4-OPrF 15931 Et-F 2-OH, 4-SnMe.sub.3 15932 Et-F 2-OMe, 4-SnMe.sub.3 15933 Et-F 2-OMeF, 4-SnMe.sub.3 15934 Et-F 2-OCF.sub.3, 4-SnMe.sub.3 15935 Et-F 2-OEtF, 4-SnMe.sub.3 15936 Et-F 2-OPrF, 4-SnMe.sub.3 15937 Me H 15938 Me 2-t-Bu 15939 Me 2-Br 15940 Me 3-Br 15941 Me 4-Br 15942 Me 2-I 15943 Me 3-I 15944 Me 4-I 15945 Me 2-SnMe.sub.3 15946 Me 3-SnMe.sub.3 15947 Me 4-SnMe, 15948 Me 2-Me 15949 Me 3-Me 15950 Me 4-Me 15951 Me 2-OH 15952 Me 3-OH 15953 Me 4-OH 15954 Me 2-OMe 15955 Me 3-OMe 15956 Me 4-OMe 15957 Me 2-OMeF 15958 Me 3-OMeF 15959 Me 4-OMeF 15960 Me 2-OCF.sub.3 15961 Me 3-OCF.sub.3 15962 Me 4-OCF.sub.3 15963 Me 2-OEtF 15964 Me 3-OEtF 15965 Me 4-OEtF 15966 Me 2-OPrF 15967 Me 3-OPrF 15968 Me 4-OPrF 15969 Me 2-SH 15970 Me 3-SH 15971 Me 4-SH 15972 Me 2-SMe 15973 Me 3-SMe 15974 Me 4-SMe 15975 Me 2-SMeF 15976 Me 3-SMeF 15977 Me 4-SMeF 15978 Me 2-SCF.sub.3 15979 Me 3-SCF.sub.3 15980 Me 4-SCF.sub.3 15981 Me 2-SEtF 15982 Me 3-SEtF 15983 Me 4-SEtF 15984 Me 2-SPrF 15985 Me 3-SPrF 15986 Me 4-SPrF 15987 Me 2-OMe, 4-OMe 15988 Me 2-Me, 5-OH 15989 Me 2-Me, 5-OMe 15990 Me 2-Me, 5-OMeF 15991 Me 2-Me, 5-OEtF 15992 Me 2-Me, 5-OPrF 15993 Me 2-Me, 4-OH 15994 Me 2-Me, 4-OMe 15995 Me 2-Me, 4-OMeF 15996 Me 2-Me, 4-OCF.sub.3 15997 Me 2-Me, 4-OEtF 15998 Me 2-Me, 4-OPrF 15999 Me 2-OH, 4-Me 16000 Me 2-OMe, 4-Me 16001 Me 2-OMeF, 4-Me 16002 Me 2-OCF.sub.3, 4-Me 16003 Me 2-OEtF, 4-Me 16004 Me 2-OPrF, 4-Me 16005 Me 2-Cl, 4-OH 16006 Me 2-Cl, 4-OMe 16007 Me 2-Cl, 4-OMeF 16008 Me 2-Cl, 4-OCF.sub.3 16009 Me 2-Cl, 4-OEtF 16010 Me 2-Cl, 4-OPrF 16011 Me 2-F, 4-F 16012 Me 2-Cl, 4-Cl 16013 Me 2-Cl, 4-F 16014 Me 2-Cl, 4-NO.sub.2 16015 Me 2-Cl, 4-NH.sub.2 16016 Me 2-Cl, 4-NHMe 16017 Me 2-Cl, 4-NMe.sub.2 16018 Me 2-Cl, 4-NMe.sub.3OTf 16019 Me 2-Cl, 4-NMe.sub.3I 16020 Me 2-Cl, 5-F 16021 Me 2-Cl, 5-NO.sub.2 16022 Me 2-Cl, 5-NH.sub.2 16023 Me 2-Cl, 5-NHMe 16024 Me 2-Cl, 5-NMe.sub.2 16025 Me 2-Cl, 5-NMe.sub.3OTf 16026 Me 2-Cl, 5- NMe.sub.3I 16027 Me 2-F, 4-Cl 16028 Me 2-NO.sub.2, 4-Cl 16029 Me 2-NH.sub.2, 4-Cl 16030 Me 2-N1IMe, 4-Cl 16031 Me 2-NMe.sub.2, 4-Cl 16032 Me 2-NMe.sub.3OTf, 4-Cl 16033 Me 2-NMe.sub.3I, 4-Cl 16034 Me 2-F, 5-Cl 16035 Me 2-NO.sub.2, 5-Cl 16036 Me 2-NH.sub.2, 5-Cl 16037 Me 2-NHMe, 5-Cl 16038 Me 2-NMe.sub.2, 5-Cl 16039 Me 2-NMe.sub.3OTf, 5-Cl 16040 Me 2-NMe.sub.3I, 5-Cl 16041 Me 2-Br, 4-F 16042 Me 2-Br, 4-NO.sub.2 16043 Me 2-Br, 4-NH.sub.2 16044 Me 2-Br, 4-NHMe 16045 Me 2-Br, 4-NMe.sub.2 16046 Me 2-Br, 4-NMe.sub.3OTf 16047 Me 2-Br, 4-NMe.sub.3I 16048 Me 2-Br, 5-F 16049 Me 2-Br, 5-NO.sub.2 16050 Me 2-Br, 5-NH.sub.2 16051 Me 2-Br, 5-NHMe 16052 Me 2-Br, 5-NMe.sub.2 16053 Me 2-Br, 5-NMe.sub.3OTf 16054 Me 2-Br, 5-NMe.sub.3I 16055 Me 2-F, 4-Br 16056 Me 2-NO.sub.2, 4-Br 16057 Me 2-NH.sub.2, 4-Br 16058 Me 2-NHMe, 4-Br 16059 Me 2-NMe.sub.2, 4-Br 16060 Me 2-NMe.sub.3OTf, 4-Br 16061 Me 2-NMe.sub.3I, 4-Br 16062 Me 2-I, 4-F 16063 Me 2-I, 4-NO.sub.2 16064 Me 2-I, 4-NH.sub.2 16065 Me 2-I, 4-NHMe 16066 Me 2-I, 4-NMe.sub.2 16067 Me 2-I, 4-NMe.sub.3OTf 16068 Me 2-I, 4-NMe.sub.3I 16069 Me 2-F, 4-I 16070 Me 2-NO.sub.2, 4-I 16071 Me 2-NH.sub.2, 4-I 16072 Me 2-NHMe, 4-I 16073 Me 2-NMe.sub.2, 4-I 16074 Me 2-NMe.sub.3OTf, 4-I 16075 Me 2-NMe.sub.3I, 4-I 16076 Me 2-Me, 3-F 16077 Me 2-Me, 3-NO.sub.2 16078 Me 2-Me, 3-NH.sub.2 16079 Me 2-Me, 3-NHMe 16080 Me 2-Me, 3-NMe.sub.2 16081 Me 2-Me, 3-NMe.sub.3OTf 16082 Me 2-Me, 3-NMe.sub.3I 16083 Me 2-Me, 4-F 16084 Me 2-Me, 4-NO.sub.2 16085 Me 2-Me, 4-NH.sub.2 16086 Me 2-Me, 4-NHMe 16087 Me 2-Me, 4-NMe.sub.2 16088 Me 2-Me, 4-NMe.sub.3OTf 16089 Me 2-Me, 4-NMe.sub.3I 16090 Me 2-Me, 5-F 16091 Me 2-Me, 5-NO.sub.2 16092 Me 2-Me, 5-NH.sub.2 16093 Me 2-Me, 5-NHMe 16094 Me 2-Me, 5-NMe.sub.2 16095 Me 2-Me, 5-NMe.sub.3OTf 16096 Me 2-Me, 5-NMe.sub.3I 16097 Me 2-F, 4-Me 16098 Me 2-NO.sub.2, 4-Me 16099 Me 2-NH.sub.2, 4-Me 16100 Me 2-NHMe, 4-Me 16101 Me 2-NMe.sub.2, 4-Me 16102 Me 2-NMe.sub.3, 4-Me 16103 Me 2-NMe.sub.3OTf, 4-Me 16104 Me 2-NMe.sub.3I, 4-Me 16105 Me 2-SnMeI, 4-F 16106 Me 2-SnMe.sub.3, 5-F 16107 Me 2-F, 4-SnMe.sub.3 16108 Me 2-Br, 6-Cl, 4-F 16109 Me 2-Br, 6-Cl, 4-NO.sub.2 16110 Me 2-Br, 6-Cl, 4-NH.sub.2 16111 Me 2-Br, 6-Cl, 4-NHMe 16112 Me 2-Br, 6-Cl, 4-NMe.sub.2 16113 Me 2-Br, 6-Cl, 4-NMe.sub.3OTf 16114 Me 2-Br, 6-Cl, 4-NMe.sub.3I 16115 Me 2-Me, 6-Cl, 4-F 16116 Me 2-SnMe.sub.3, 6-Cl, 4-F 16117 Me 2-Cl, 4-Me 16118 Me 2-Cl, 4-Br 16119 Me 2-Cl, 4-SnMe.sub.3 16120 Me 2-Br, 4-Cl 16121 Me 2-SnMe.sub.3, 4-Cl 16122 Me 2-Me, 4-Cl 16123 Me 2-Br, 4-Br 16124 Me 2-Br, 4-Me 16125 Me 2-Br, 4-SnMe.sub.3 16126 Me 2-SnMe.sub.3, 4-Br 16127 Me 2-Me, 4-Br 16128 Me 2-Me, 4-SnMe.sub.3 16129 Me 2-SnMe.sub.3, 4-Me 16130 Me 2-Me, 4-Me 16131 Me 2-Et, 4-Br 16132 Me 2-Et, 4-SnMe.sub.3 16133 Me 2-Et, 4-Me 16134 Me 2-Me, 4-Me, 6-Me 16135 Me 2-Me, 4-Br, 6-Me 16136 Me 2-Me, 4-SnMe.sub.3, 6-Me 16137 Me 2-Et, 6-Me 16138 Me 2-Br, 4-i-Pr 16139 Me 2-SnMe.sub.3, 4-i-Pr 16140 Me 2-Me, 4-i-Pr 16141 Me 2-Br, 4-Br, 6-Br 16142 Me 2-Br, 4-Me, 6-Br 16143 Me 2-Br, 4-SnMe.sub.3, 6-Br 16144 Me 2-SnMe.sub.3, 4-Br, 6-Br 16145 Me 2-Br, 4-Br, 6-Me 16146 Me 2-Br, 4-CF.sub.3, 6-Br 16147 Me 2-Br, 4-Br, 6-CF.sub.3 16148 Me 2-CF.sub.3, 4-CF.sub.3 16149 Me 2-Cl, 4-CF.sub.3 16150 Me 2-CF.sub.3, 4-Cl 16151 Me 2-Br, 4-CF.sub.3 16152 Me 2-SnMe.sub.3, 4-CF.sub.3 16153 Me 2-Me, 4-CF.sub.3 16154 Me 2-CF.sub.3, 4-Br 16155 Me 2-CF.sub.3, 4-SnMe.sub.3

16156 Me 2-CF.sub.3, 4-Me 16157 Me 2-Br, 4-OH 16158 Me 2-Br, 4-OMe 16159 Me 2-Br, 4-OMeF 16160 Me 2-Br, 4-OCF.sub.3 16161 Me 2-Br, 4-OEtF 16162 Me 2-Br, 4-OPrF 16163 Me 2-OH, 4-Br 16164 Me 2-OMe, 4-Br 16165 Me 2-OMeF, 4-Br 16166 Me 2-OCF.sub.3, 4-Br 16167 Me 2-OEtF, 4-Br 16168 Me 2-OPrF, 4-Br 16169 Me 2-I, 4-OH 16170 Me 2-I, 4-OMe 16171 Me 2-I, 4-OMeF 16172 Me 2-I, 4-OCF.sub.3 16173 Me 2-I, 4-OEtF 16174 Me 2-I, 4-OPrF 16175 Me 2-OH, 4-I 16176 Me 2-OMe, 4-I 16177 Me 2-OMeF, 4-I 16178 Me 2-OCF.sub.3, 4-I 16179 Me 2-OEtF, 4-I 16180 Me 2-OPrF, 4-I 16181 Me 2-SnMe.sub.3, 4-OH 16182 Me 2-SnMe.sub.3, 4-OMe 16183 Me 2-SnMe.sub.3, 4-OMeF 16184 Me 2-SnMe.sub.3, 4-OCF.sub.3 16185 Me 2-SnMe.sub.3, 4-OEtF 16186 Me 2-SnMe.sub.3, 4-OPrF 16187 Me 2-OH, 4-SnMe.sub.3 16188 Me 2-OMe, 4-SnMe.sub.3 16189 Me 2-OMeF, 4-SnMe.sub.3 16190 Me 2-OCF.sub.3, 4-SnMe.sub.3 16191 Me 2-OEtF, 4-SnMe.sub.3 16192 Me 2-OPrF, 4-SnMe.sub.3 16193 Me-F H 16194 Me-F 2-t-Bu 16195 Me-F 2-Br 16196 Me-F 3-Br 16197 Me-F 4-Br 16198 Me-F 2-I 16199 Me-F 3-I 16200 Me-F 4-I 16201 Me-F 2-SnMe.sub.3 16202 Me-F 3-SnMe.sub.3 16203 Me-F 4-SnMe.sub.3 16204 Me-F 2-Me 16205 Me-F 3-Me 16206 Me-F 4-Me 16207 Me-F 2-OH 16208 Me-F 3-OH 16209 Me-F 4-OH 16210 Me-F 2-OMe 16211 Me-F 3-OMe 16212 Me-F 4-OMe 16213 Me-F 2-OMeF 16214 Me-F 3-OMeF 16215 Me-F 4-OMeF 16216 Me-F 2-OCF.sub.3 16217 Me-F 3-OCF.sub.3 16218 Me-F 4-OCF.sub.3 16219 Me-F 2-OEtF 16220 Me-F 3-OEtF 16221 Me-F 4-OEtF 16222 Me-F 2-OPrF 16223 Me-F 3-OPrF 16224 Me-F 4-OPrF 16225 Me-F 2-SH 16226 Me-F 3-SH 16227 Me-F 4-SH 16228 Me-F 2-SMe 16229 Me-F 3-SMe 16230 Me-F 4-SMe 16231 Me-F 2-SMeF 16232 Me-F 3-SMeF 16233 Me-F 4-SMeF 16234 Me-F 2-SCF.sub.3 16235 Me-F 3-SCF.sub.3 16236 Me-F 4-SCF.sub.3 16237 Me-F 2-SEtF 16238 Me-F 3-SEtF 16239 Me-F 4-SEtF 16240 Me-F 2-8PrF 16241 Me-F 3-SPrF 16242 Me-F 4-SPrF 16243 Me-F 2-OMe, 4-OMe 16244 Me-F 2-Me, 5-OH 16245 Me-F 2-Me, 5-OMe 16246 Me-F 2-Me, 5-OMeF 16247 Me-F 2-Me, 5-OEtF 16248 Me-F 2-Me, 5-OPrF 16249 Me-F 2-Me, 4-OH 16250 Me-F 2-Me, 4-OMe 16251 Me-F 2-Me, 4-OMeF 16252 Me-F 2-Me, 4-OCF.sub.3 16253 Me-F 2-Me, 4-OEtF 16254 Me-F 2-Me, 4-OPrF 16255 Me-F 2-OH, 4-Me 16256 Me-F 2-OMe, 4-Me 16257 Me-F 2-OMeF, 4-Me 16258 Me-F 2-OCF.sub.3, 4-Me 16259 Me-F 2-OEtF, 4-Me 16260 Me-F 2-OPrF, 4-Me 16261 Me-F 2-Cl, 4-OH 16262 Me-F 2-Cl, 4-OMe 16263 Me-F 2-Cl, 4-OMeF 16264 Me-F 2-Cl, 4-OCF.sub.3 16265 Me-F 2-Cl, 4-OEtF 16266 Me-F 2-Cl, 4-OPrF 16267 Me-F 2-F, 4-F 16268 Me-F 2-Cl, 4-Cl 16269 Me-F 2-Cl, 4-F 16270 Me-F 2-Cl, 4-NO.sub.2 16271 Me-F 2-Cl, 4-NH.sub.2 16272 Me-F 2-Cl, 4-NHMe 16273 Me-F 2-Cl, 4-NMe.sub.2 16274 Me-F 2-Cl, 4-NMe.sub.3OTf 16275 Me-F 2-Cl, 4-NMe.sub.3I 16276 Me-F 2-Cl, 5-F 16277 Me-F 2-Cl, 5-NO.sub.2 16278 Me-F 2-Cl, 5-NH.sub.2 16279 Me-F 2-Cl, 5-NHMe 16280 Me-F 2-Cl, 5-NMe.sub.2 16281 Me-F 2-Cl, 5-NMe.sub.3OTf 16282 Me-F 2-Cl, 5- NMe.sub.3I 16283 Me-F 2-F, 4-Cl 16284 Me-F 2-NO.sub.2, 4-Cl 16285 Me F 2-NH.sub.2, 4-Cl 16286 Me-F 2-NHMe, 4-Cl 16287 Me-F 2-NMe.sub.2, 4-Cl 16288 Me-F 2-NMe.sub.3OTf, 4-Cl 16289 Me-F 2-NMe.sub.3I, 4-Cl 16290 Me-F 2-F, 5-Cl 16291 Me-F 2-NO.sub.2, 5-Cl 16292 Me-F 2-NH.sub.2, 5-Cl 16293 Me-F 2-NHMe, 5-Cl 16294 Me-F 2-NMe.sub.2, 5-Cl 16295 Me-F 2-NMe.sub.3OTf, 5-Cl 16296 Me-F 2-NMe.sub.3I, 5-Cl 16297 Me-F 2-Br, 4-F 16298 Me-F 2-Br, 4-NO.sub.2 16299 Me-F 2-Br, 4-NH.sub.2 16300 Me-F 2-Br, 4-NHMe 16301 Me-F 2-Br, 4-NMe.sub.2 16302 Me-F 2-Br, 4-NMe.sub.3OTf 16303 Me-F 2-Br, 4-NMe.sub.3I 16304 Me-F 2-Br, 5-F 16305 Me-F 2-Br, 5-NO.sub.2 16306 Me-F 2-Br, 5-NH.sub.2 16307 Me-F 2-Br, 5-NHMe 16308 Me-F 2-Br, 5-NMe.sub.2 16309 Me-F 2-Rr, 5-NMe.sub.3OTf 16310 Me-F 2-Br, 5-NMe.sub.3I 16311 Me-F 2-F, 4-Br 16312 Me-F 2-NO.sub.2, 4-Br 16313 Me-F 2-NH.sub.2, 4-Br 16314 Me-F 2-NHMe, 4-Br 16315 Me-F 2-NMe.sub.2, 4-Br 16316 Me-F 2-NMe.sub.2OTf, 4-Br 16317 Me-F 2-NMe.sub.3I, 4-Br 16318 Me-F 2-I, 4-F 16319 Me-F 2-I, 4-NO.sub.2 16320 Me-F 2-I, 4-NH.sub.2 16321 Me-F 2-I, 4-NHMe 16322 Me-F 2-I, 4-NMe.sub.2 16323 Me-F 2-I, 4-NMe.sub.3OTf 16324 Me-F 2-I, 4-NMe.sub.3I 16325 Me-F 2-F, 4-I 16326 Me-F 2-NO.sub.2, 4-I 16327 Me-F 2-NH.sub.2, 4-I 16328 Me-F 2-NHMe, 4-I 16329 Me-F 2-NMe.sub.2, 4-I 16330 Me-F 2-NMe.sub.3OTf, 4-I 16331 Me-F 2-NMe.sub.3I, 4-I 16332 Me-F 2-Me, 3-F 16333 Me-F 2-Me, 3-NO.sub.2 16334 Me-F 2-Me, 3-NH.sub.2 16335 Me-F 2-Me, 3-NHMe 16336 Me-F 2-Me, 3-NMe.sub.2 16337 Me-F 2-Me, 3-NMe.sub.3OTf 16338 Me-F 2-Me, 3-NMe.sub.3I 16339 Me-F 2-Me, 4-F 16340 Me-F 2-Me, 4-NO.sub.2 16341 Me-F 2-Me, 4-NH.sub.2 16342 Me-F 2-Me, 4-NHMe 16343 Me-F 2-Me, 4-NMe.sub.2 16344 Me-F 2-Me, 4-NMe.sub.3OTf 16345 Me-F 2-Me, 4-NMe.sub.3I 16346 Me-F 2-Me, 5-F 16347 Me-F 2-Me, 5-NO.sub.2 16348 Me-F 2-Me, 5-NH.sub.2 16349 Me-F 2-Me, 5-NHMe 16350 Me-F 2-Me, 5-NMe.sub.2 16351 Me-F 2-Me, 5-NMe.sub.3OTf 16352 Me-F 2-Me, 5-NMe.sub.3I 16353 Me-F 2-F, 4-Me 16354 Me-F 2-NO.sub.2, 4-Me 16355 Me-F 2-NH.sub.2, 4-Me 16356 Me-F 2-NHMe, 4-Me 16357 Me-F 2-NMe.sub.2, 4-Me 16358 Me-F 2-NMe.sub.3, 4-Me 16359 Me-F 2-NMe.sub.3OTf, 4-Me 16360 Me-F 2-NMe.sub.3I, 4-Me 16361 Me-F 2-SnMe.sub.3, 4-F 16362 Me-F 2-SnMe.sub.3, 5-F 16363 Me-F 2-F, 4-SnMe.sub.3 16364 Me-F 2-Br, 6-Cl, 4-F 16365 Me-F 2-Br, 6-Cl, 4-NO.sub.2 16366 Me-F 2-Br, 6-Cl, 4-NH.sub.2 16367 Me-F 2-Br, 6-Cl, 4-NHMe 16368 Me-F 2-Br, 6-Cl, 4-NMe.sub.2 16369 Me-F 2-Br, 6-Cl, 4-NMe.sub.3OTf 16370 Me-F 2-Br, 6-Cl, 4-NMe.sub.3I 16371 Me-F 2-Me, 6-Cl, 4-F 16372 Me-F 2-SnMe.sub.3, 6-Cl, 4-F 16373 Me-F 2-Cl, 4-Me 16374 Me-F 2-Cl, 4-Br 16375 Me-F 2-Cl, 4-SnMe.sub.3 16376 Me-F 2-Br, 4-Cl 16377 Me-F 2-SnMe.sub.3, 4-Cl 16378 Me-F 2-Me, 4-Cl 16379 Me-F 2-Br, 4-Br 16380 Me-F 2-Br, 4-Me 16381 Me-F 2-Br, 4-SnMe.sub.3 16382 Me-F 2-SnMe.sub.3, 4-Br 16383 Me-F 2-Me, 4-Br 16384 Me-F 2-Me, 4-SnMe.sub.3 16385 Me-F 2-SnMe.sub.3, 4-Me 16386 Me-F 2-Me, 4-Me 16387 Me-F 2-Et, 4-Br 16388 Me-F 2-Et, 4-SnMe.sub.3 16389 Me-F 2-Et, 4-Me 16390 Me-F 2-Me, 4-Me, 6-Me 16391 Me-F 2-Me, 4-Br, 6-Me 16392 Me-F 2-Me, 4-SnMe.sub.3, 6-Me 16393 Me-F 2-Et, 6-Me 16394 Me-F 2-Br, 4-i-Pr 16395 Me-F 2-SnMe.sub.3, 4-i-Pr 16396 Me-F 2-Me, 4-i-Pr 16397 Me-F 2-Br, 4-Br, 6-Br 16398 Me-F 2-Br, 4-Me, 6-Br 16399 Me-F 2-Br, 4-SnMe.sub.3, 6-Br 16400 Me-F 2-SnMe.sub.3, 4-Br, 6-Br 16401 Me-F 2-Br, 4-Br, 6-Me 16402 Me-F 2-Br, 4-CF.sub.3, 6-Br 16403 Me-F 2-Br, 4-Br, 6-CF.sub.3 16404 Me-F 2-CF.sub.3, 4-CF.sub.3 16405 Me-F 2-Cl, 4-CF.sub.3 16406 Me-F 2-CF.sub.3, 4-Cl

16407 Me-F 2-Br, 4-CF.sub.3 16408 Me-F 2-SnMe.sub.3, 4-CF.sub.3 16409 Me-F 2-Me, 4-CF.sub.3 16410 Me-F 2-CF.sub.3, 4-Br 16411 Me-F 2-CF.sub.3, 4-SnMe.sub.3 16412 Me-F 2-CF.sub.3, 4-Me 16413 Me-F 2-Br, 4-OH 16414 Me-F 2-Br, 4-OMe 16415 Me-F 2-Br, 4-OMeF 16416 Me-F 2-Br, 4-OCF.sub.3 16417 Me-F 2-Br, 4-OEtF 16418 Me-F 2-Br, 4-OPrF 16419 Me-F 2-OH, 4-Br 16420 Me-F 2-OMe, 4-Br 16421 Me-F 2-OMeF, 4-Br 16422 Me-F 2-OCF.sub.3, 4-Br 16423 Me-F 2-OEtF, 4-Br 16424 Me-F 2-OPrF, 4-Br 16425 Me-F 2-I, 4-OH 16426 Me-F 2-I, 4-OMe 16427 Me-F 2-I, 4-OMeF 16428 Me-F 2-I, 4-OCF.sub.3 16429 Me-F 2-I, 4-OEtF 16430 Me-F 2-I, 4-OPrF 16431 Me-F 2-OH, 4-I 16432 Me-F 2-OMe, 4-I 16433 Me-F 2-OMeF, 4-I 16434 Me-F 2-OCF.sub.3, 4-I 16435 Me-F 2-OEtF, 4-I 16436 Me-F 2-OPrF, 4-I 16437 Me-F 2-SnMe.sub.3, 4-OH 16438 Me-F 2-SnMe.sub.3, 4-OMe 16439 Me-F 2-SnMe.sub.3, 4-OMeF 16440 Me-F 2-SnMe.sub.3, 4-OCF.sub.3 16441 Me-F 2-SnMe.sub.3, 4-OEtF 16442 Me-F 2-SnMe.sub.3, 4-OPrF 16443 Me-F 2-OH, 4-SnMe.sub.3 16444 Me-F 2-OMe, 4-SnMe.sub.3 16445 Me-F 2-OMeF, 4-SnMe.sub.3 16446 Me-F 2-OCF.sub.3, 4-SnMe.sub.3 16447 Me-F 2-OEtF, 4-SnMe.sub.3 16448 Me-F 2-OPrF, 4-SnMe.sub.3 16449 FCH.sub.2--CH.dbd.CH--CH.sub.2 H 16450 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-t-Bu 16451 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br 16452 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Br 16453 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Br 16454 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I 16455 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-I 16456 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-I 16457 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3 16458 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SnMe.sub.3 16459 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SnMe.sub.3 16460 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me 16461 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-Me 16462 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-Me 16463 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH 16464 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OH 16465 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OH 16466 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe 16467 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMe 16468 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMe 16469 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF 16470 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OMeF 16471 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OMeF 16472 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3 16473 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-O0-'3 16474 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OCF.sub.3 16475 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF 16476 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OEtF 16477 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OEtF 16478 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF 16479 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-OPrF 16480 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-OPrF 16481 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SH 16482 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SH 16483 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SH 16484 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMe 16485 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMe 16486 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMe 16487 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SMeF 16488 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SMeF 16489 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SMeF 16490 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SCF.sub.3 16491 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SCF.sub.3 16492 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SCF.sub.3 16493 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SEtF 16494 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SEtF 16495 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SEtF 16496 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SPrF 16497 FCH.sub.2--CH.dbd.CH--CH.sub.2 3-SPrF 16498 FCH.sub.2--CH.dbd.CH--CH.sub.2 4-SPrF 16499 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-OMe 16500 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OH 16501 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMe 16502 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OMeF 16503 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OEtF 16504 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-OPrF 16505 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OH 16506 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMe 16507 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OMeF 16508 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OCF.sub.3 16509 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OEtF 16510 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-OPrF 16511 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Me 16512 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-Me 16513 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Me 16514 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Me 16515 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Me 16516 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Me 16517 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OH 16518 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMe 16519 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OMeF 16520 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OCF.sub.3 16521 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OEtF 16522 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-OPrF 16523 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-F 16524 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Cl 16525 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-F 16526 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NO.sub.2 16527 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NH.sub.2 16528 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NHMe 16529 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.2 16530 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3OTf 16531 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-NMe.sub.3I 16532 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-F 16533 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NO.sub.2 16534 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NH.sub.2 16535 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NHMe 16536 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.2 16537 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5-NMe.sub.3OTf 16538 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 5- NMe.sub.3I 16539 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Cl 16540 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Cl 16541 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Cl 16542 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Cl 16543 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Cl 16544 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Cl 16545 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Cl 16546 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 5-Cl 16547 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 5-Cl 16548 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 5-Cl 16549 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 5 Cl 16550 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 5-Cl 16551 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 5-Cl 16552 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 5-Cl 16553 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-F 16554 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NO.sub.2 16555 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NH.sub.2 16556 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NHMe 16557 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.2 16558 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe.sub.3OTf 16559 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-NMe,I 16560 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-F 16561 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NO.sub.2 16562 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NH.sub.2 16563 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NHMe 16564 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.2 16565 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe,OTf 16566 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 5-NMe.sub.3I 16567 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Br 16568 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Br 16569 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Br 16570 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Br 16571 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Br 16572 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-Br 16573 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Br 16574 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-F 16575 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NO.sub.2 16576 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NH.sub.2 16577 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NHMe 16578 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.2 16579 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3OTf 16580 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-NMe.sub.3I 16581 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-I 16582 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-I 16583 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-I 16584 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-I 16585 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-I 16586 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 4-I 16587 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-I 16588 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-F 16589 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NO.sub.2 16590 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NH.sub.2 16591 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NHMe 16592 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.2 16593 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3OTf 16594 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 3-NMe.sub.3I 16595 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-F 16596 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NO.sub.2 16597 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NH.sub.2 16598 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NHMe 16599 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.2 16600 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3OTf 16601 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-NMe.sub.3I 16602 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-F 16603 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NO.sub.2 16604 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NH.sub.2 16605 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NHMe 16606 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.2 16607 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3OTf 16608 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 5-NMe.sub.3I 16609 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-Me 16610 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NO.sub.2, 4-Me 16611 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NH.sub.2, 4-Me 16612 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NHMe, 4-Me 16613 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.2, 4-Me 16614 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3, 4-Me 16615 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3OTf, 1-Me 16616 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-NMe.sub.3I, 4-Me 16617 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-F 16618 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 5-F 16619 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-F, 4-SnMe.sub.3 16620 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-F 16621 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NO.sub.2 16622 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NH.sub.2 16623 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NHMe 16624 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NMe.sub.2 16625 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NMe.sub.3OTf 16626 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 6-Cl, 4-NMe.sub.3I 16627 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 6-Cl, 4-F 16628 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 6-Cl, 4-F 16629 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Me 16630 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-Br 16631 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-SnMe.sub.3 16632 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Cl 16633 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Cl 16634 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Cl 16635 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br 16636 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Me 16637 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3 16638 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br 16639 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br 16640 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3 16641 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Me 16642 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me 16643 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Br 16644 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-SnMe.sub.3 16645 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 4-Me 16646 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Me, 6-Me 16647 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-Br, 6-Me 16648 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-SnMe.sub.3, 6-Me 16649 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Et, 6-Me 16650 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-i-Pr 16651 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-i-Pr 16652 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-i-Pr 16653 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Br 16654 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Me, 6-Br 16655 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-SnMe.sub.3, 6-Br 16656 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-Br, 6-Br 16657 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-Me

16658 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3, 6-Br 16659 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-Br, 6-CF.sub.3 16660 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-CF.sub.3 16661 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Cl, 4-CF.sub.3 16662 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Cl 16663 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-CF.sub.3 16664 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-CF.sub.3 16665 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Me, 4-CF.sub.3 16666 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Br 16667 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-SnMe.sub.3 16668 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-CF.sub.3, 4-Me 16669 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OH 16670 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMe 16671 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OMeF 16672 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OCF.sub.3 16673 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OEtF 16674 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-Br, 4-OPrF 16675 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-Br 16676 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-Br 16677 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-Br 16678 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-Br 16679 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-Br 16680 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-Br 16681 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OH 16682 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMe 16683 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OMeF 16684 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OCF.sub.3 16685 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OEtF 16686 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-I, 4-OPrF 16687 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-I 16688 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-I 16689 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-I 16690 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-I 16691 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-I 16692 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-I 16693 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OH 16694 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMe 16695 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OMeF 16696 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OCF.sub.3 16697 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OEtF 16698 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-SnMe.sub.3, 4-OPrF 16699 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OH, 4-SnMe.sub.3 16700 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMe, 4-SnMe.sub.3 16701 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OMeF, 4-SnMe.sub.3 16702 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OCF.sub.3, 4-SnMe.sub.3 16703 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OEtF, 4-SnMe.sub.3 16704 FCH.sub.2--CH.dbd.CH--CH.sub.2 2-OPrF, 4-SnMe.sub.3 16705 Bn H 16706 Bn 2-t-Bu 16707 Bn 2-Br 16708 Bn 3-Br 16709 Bn 4-Br 16710 Bn 2-I 16711 Bn 3-I 16712 Bn 4-I 16713 Bn 2-SnMe.sub.3 16714 Bn 3-SnMe.sub.3 16715 Bn 4-SnMe.sub.3 16716 Bn 2-Me 16717 Bn 3-Me 16718 Bn 4-Me 16719 Bn 2-OH 16720 Bn 3-OH 16721 Bn 4-OH 16722 Bn 2-OMe 16723 Bn 3-OMe 16724 Bn 4-OMe 16725 Bn 2-OMeF 16726 Bn 3-OMeF 16727 Bn 4-OMeF 16728 Bn 2-OCF.sub.3 16729 Bn 3-OCF.sub.3 16730 Bn 4-OCF.sub.3 16731 Bn 2-OEtF 16732 Bn 3-OEtF 16733 Bn 4-OEtF 16734 Bn 2-OPrF 16735 Bn 3-OPrF 16736 Bn 4-OPrF 16737 Bn 2-SH 16738 Bn 3-SH 16739 Bn 4-SH 16740 Bn 2-SMe 16741 Bn 3-SMe 16742 Bn 4-SMe 16743 Bn 2-SMeF 16744 Bn 3-SMeF 16745 Bn 4-SMeF 16746 Bn 2-SCF.sub.3 16747 Bn 3-SCF.sub.3 16748 Bn 4-SCF.sub.3 16749 Bn 2-SEtF 16750 Bn 3-SEtF 16751 Bn 4-SEtF 16752 Bn 2-SPrF 16753 Bn 3-SPrF 16754 Bn 4-SPrF 16755 Bn 2-OMe, 4-OMe 16756 Bn 2-Me, 5-OH 16757 Bn 2-Me, 5-OMe 16758 Bn 2-Me, 5-OMeF 16759 Bn 2-Me, 5-OEtF 16760 Bn 2-Me, 5-OPrF 16761 Bn 2-Me, 4-OH 16762 Bn 2-Me, 4-OMe 16763 Bn 2-Me, 4-OMeF 16764 Bn 2-Me, 4-OCF.sub.3 16765 Bn 2-Me, 4-OEtF 16766 Bn 2-Me, 4-OPrF 16767 Bn 2-OH, 4-Me 16768 Bn 2-OMe, 4-Me 16769 Bn 2-OMeF, 4-Me 16770 Bn 2-OCF.sub.3, 4-Me 16771 Bn 2-OEtF, 4-Me 16772 Bn 2-OPrF, 4-Me 16773 Bn 2-Cl, 4-OH 16774 Bn 2-Cl, 4-OMe 16775 Bn 2-Cl, 4-OMeF 16776 Bn 2-Cl, 4-OCF.sub.3 16777 Bn 2-Cl, 4-OEtF 16778 Bn 2-Cl, 4-OPrF 16779 Bn 2-F, 4-F 16780 Bn 2-Cl, 4-Cl 16781 Bn 2-Cl, 4-F 16782 Bn 2-Cl, 4-NO.sub.2 16783 Bn 2-Cl, 4-NH.sub.2 16784 Bn 2-Cl, 4-NHMe 16785 Bn 2-Cl, 4-NMe.sub.2 16786 Bn 2-Cl, 4-NMe.sub.3OTf 16787 Bn 2-Cl, 4-NMe.sub.3I 16788 Bn 2-Cl, 5-F 16789 Bn 2-Cl, 5-NO.sub.2 16790 Bn 2-Cl, 5-NH.sub.2 16791 Bn 2-Cl, 5-NHMe 16792 Bn 2-Cl, 5-NMe.sub.2 16793 Bn 2-Cl, 5-NMe.sub.3OTf 16794 Bn 2-Cl, 5-NMe.sub.3I 16795 Bn 2-F, 4-Cl 16796 Bn 2-NO.sub.2, 4-Cl 16797 Bn 2-NH.sub.2, 4-Cl 16798 Bn 2-NHMe, 4-Cl 16799 Bn 2-NMe.sub.2, 4-Cl 16800 Bn 2-NMe.sub.3OTf, 4-Cl 16801 Bn 2-NMe.sub.3I, 4-Cl 16802 Bn 2-F, 5-Cl 16803 Bn 2-NO.sub.2, 5-Cl 16804 Bn 2-NH.sub.2, 5-Cl 16805 Bn 2-NHMe, 5-Cl 16806 Bn 2-NMe.sub.2, 5-Cl 16807 Bn 2-NMe.sub.3OTf, 5-Cl 16808 Bn 2-NMe.sub.3I, 5-Cl 16809 Bn 2-Br, 4-F 16810 Bn 2-Br, 4-NO.sub.2 16811 Bn 2-Br, 4-NH.sub.2 16812 Bn 2-Br, 4-NHMe 16813 Bn 2-Br, 4-NMe.sub.2 16814 Bn 2-Br, 4-NMe.sub.3OTf 16815 Bn 2-Br, 4-NMe.sub.3I 16816 Bn 2-Br, 5-F 16817 Bn 2-Br, 5-NO.sub.2 16818 Bn 2-Br, 5-NH.sub.2 16819 Bn 2-Br, 5-NHMe 16820 Bn 2-Br, 5-NMe.sub.2 16821 Bn 2-Br, 5-NMe.sub.3OTf 16822 Bn 2-Br, 5-NMe.sub.3I 16823 Bn 2-F, 4-Br 16824 Bn 2-NO.sub.2, 4-Br 16825 Bn 2-NH.sub.2, 4-Br 16826 Bn 2-NHMe, 4-Br 16827 Bn 2-NMe.sub.2, 4-Br 16828 Bn 2-NMe.sub.3OTf, 4-Br 16829 Bn 2-NMe.sub.3I, 4-Br 16830 Bn 2-I, 4-F 16831 Bn 2-I, 4-NO.sub.2 16832 Bn 2-I, 4-NH.sub.2 16833 Bn 2-I, 4-NHMe 16834 Bn 2-I, 4-NMe.sub.2 16835 Bn 2-I, 4-NMe.sub.3OTf 16836 Bn 2-I, 4-NMe.sub.3I 16837 Bn 2-F, 4-I 16838 Bn 2-NO.sub.2, 4-I 16839 Bn 2-NH.sub.2, 4-I 16840 Bn 2-NHMe, 4-I 16841 Bn 2-NMe.sub.2, 4-I 16842 Bn 2-NMe.sub.3OTf, 4-I 16843 Bn 2-NMe.sub.3I, 4-I 16844 Bn 2-Me, 3-F 16845 Bn 2-Me, 3-NO.sub.2 16846 Bn 2-Me, 3-NH.sub.2 16847 Bn 2-Me, 3-NHMe 16848 Bn 2-Me, 3-NMe.sub.2 16849 Bn 2-Me, 3-NMe.sub.3OTf 16850 Bn 2-Me, 3-NMe.sub.3I 16851 Bn 2-Me, 4-F 16852 Bn 2-Me, 4-NO.sub.2 16853 Bn 2-Me, 4-NH.sub.2 16854 Bn 2-Me, 4-NHMe 16855 Bn 2-Me, 4-NMe.sub.2 16856 Bn 2-Me, 4-NMe.sub.3OTf 16857 Bn 2-Me, 4-NMe.sub.3I 16858 Bn 2-Me, 5-F 16859 Bn 2-Me, 5-NO.sub.2 16860 Bn 2-Me, 5-NH.sub.2 16861 Bn 2-Me, 5-NHMe 16862 Bn 2-Me, 5-NMe.sub.2 16863 Bn 2-Me, 5-NMe.sub.3OTf 16864 Bn 2-Me, 5-NMe.sub.3I 16865 Bn 2-F, 4-Me 16866 Bn 2-NO.sub.2, 4-Me 16867 Bn 2-NH.sub.2, 4-Me 16868 Bn 2-NHMe, 4-Me 16869 Bn 2-NMe.sub.2, 4-Me 16870 Bn 2-NMe.sub.3, 4-Me 16871 Bn 2-NMe.sub.3OTf, 4-Me 16872 Bn 2-NMe.sub.3I, 4-Me 16873 Bn 2-SnMe.sub.3, 4-F 16874 Bn 2-SnMe.sub.3, 5-F 16875 Bn 2-F, 4-SnMe.sub.3 16876 Bn 2-Br, 6-Cl, 4-F 16877 Bn 2-Br, 6-Cl, 4-NO.sub.2 16878 Bn 2-Br, 6-Cl, 4-NH.sub.2 16879 Bn 2-Br, 6-Cl, 4 NHMe 16880 Bn 2-Br, 6-Cl, 4-NMe.sub.2 16881 Bn 2-Br, 6-Cl, 4-NMe.sub.3OTf 16882 Bn 2-Br, 6-Cl, 4-NMe.sub.3I 16883 Bn 2-Me, 6-Cl, 4-F 16884 Bn 2-SnMe.sub.3, 6-Cl, 4-F 16885 Bn 2-Cl, 4-Me 16886 Bn 2-Cl, 4-Br 16887 Bn 2-Cl, 4-SnMe.sub.3 16888 Bn 2-Br, 4-Cl 16889 Bn 2-SnMe.sub.3, 4-Cl 16890 Bn 2-Me, 4-Cl 16891 Bn 2-Br, 4-Br 16892 Bn 2-Br, 4-Me 16893 Bn 2-Br, 4-SnMe.sub.3 16894 Bn 2-SnMe.sub.3, 4-Br 16895 Bn 2-Me, 4-Br 16896 Bn 2-Me, 4-SnMe.sub.3 16897 Bn 2-SnMe.sub.3, 4-Me 16898 Bn 2-Me, 4-Me 16899 Bn 2-Et, 4-Br 16900 Bn 2-Et, 4-SnMe.sub.3 16901 Bn 2-Et, 4-Me 16902 Bn 2-Me, 4-Me, 6-Me 16903 Bn 2-Me, 4-Br, 6-Me 16904 Bn 2-Me, 4-SnMe.sub.3, 6-Me 16905 Bn 2-Et, 6-Me 16906 Bn 2-Br, 4-i-Pr 16907 Bn 2-SnMe.sub.3, 4-i-Pr 16908 Bn 2-Me, 4-i-Pr

16909 Bn 2-Br, 4-Br, 6-Br 16910 Bn 2-Br, 4-Me, 6-Br 16911 Bn 2-Br, 4-SnMe.sub.3, 6-Br 16912 Bn 2-SnMe.sub.3, 4-Br, 6-Br 16913 Bn 2-Br, 4-Br, 6-Me 16914 Bn 2-Br, 4-CF.sub.3, 6-Br 16915 Bn 2-Br, 4-Br, 6-CF.sub.3 16916 Bn 2-CF.sub.3, 4-CF.sub.3 16917 Bn 2-Cl, 4-CF.sub.3 16918 Bn 2-CF.sub.3, 4-Cl 16919 Bn 2-Br, 4-CF.sub.3 16920 Bn 2-SnMe.sub.3, 4-CF.sub.3 16921 Be 2-Me, 4-CF.sub.3 16922 Bn 2-CF.sub.3, 4-Br 16923 Bn 2-CF.sub.3, 4-SnMe.sub.3 16924 Bn 2-CF.sub.3, 4-Me 16925 Bn 2-Br, 4-OH 16926 Bn 2-Br, 4-OMe 16927 Bn 2-Br, 4-OMeF 16928 Bn 2-Br, 4-OCF.sub.3 16929 Bn 2-Br, 4-OEtF 16930 Bn 2-Br, 4-OPrF 16931 Bn 2-OH, 4-Br 16932 Bn 2-OMe, 4-Br 16933 Bn 2-OMeF, 4-Br 16934 Bn 2-OCF.sub.3, 4-Br 16935 Bn 2-OEtF, 4-Br 16936 Bn 2-OPrF, 4-Br 16937 Bn 2-I, 4-OH 16938 Bn 2-I, 4-OMe 16939 Bn 2-I, 4-OMeF 16940 Bn 2-I, 4-OCF.sub.3 16941 Bn 2-I, 4-OEtF 16942 Bn 2-I, 4-OPrF 16943 Bn 2-OH, 4-I 16944 Bn 2-OMe, 4-I 16945 Bn 2-OMeF, 4-I 16946 Bn 2-OCF.sub.3, 4-I 16947 Bn 2-OEtF, 4-4 16948 Bn 2-OPrF, 4-I 16949 Bn 2-SnMe.sub.3, 4-OH 16950 Bn 2-SnMe.sub.3, 4-OMe 16951 3n 2-SnMe.sub.3, 4-OMeF 16952 Bn 2-SnMe.sub.3, 4-OCF.sub.3 16953 Bn 2-SnMe.sub.3, 4-OEtF 16954 Bn 2-SnMe.sub.3, 4-OPrF 16955 Bn 2-OH, 4-SnMe.sub.3 16956 Bn 2-OMe, 4-SnMe.sub.3 16957 Bn 2-OMeF, 4-SnMe.sub.3 16958 Bn 2-OCF.sub.3, 4-SnMe.sub.3 16959 Bn 2-OEtF, 4-SnMe.sub.3 16960 Bn 2-OPrF, 4-SnMe.sub.3 16961 H H 16962 H 2-t-Bu 16963 H 2-Br 16964 H 3-Br 16965 H 4-Br 16966 H 2-I 16967 H 3-I 16968 H 4-I 16969 H 2-SnMe.sub.3 16970 H 3-SnMe.sub.3 16971 H 4-SnMe.sub.3 16972 H 2-Me 16973 H 3-Me 16974 H 4-Me 16975 H 2-OH 16976 H 3-OH 16977 H 4-OH 16978 H 2-OMe 16979 H 3-OMe 16980 H 4-OMe 16981 H 2-OMeF 16982 H 3-OMeF 16983 H 4-OMeF 16984 H 2-OCF.sub.3 16985 H 3-OCF.sub.3 16986 H 4-OCF.sub.3 16987 H 2-OEtF 16988 H 3-OEtF 16989 H 4-OEtF 16990 H 2-OPrF 16991 H 3-OPrF 16992 H 4-OPrF 16993 H 2-SH 16994 H 3-SH 16995 H 4-SH 16996 H 2-SMe 16997 H 3-SMe 16998 H 4-SMe 16999 H 2-SMeF 17000 H 3-SMeF 17001 H 4-SMeF 17002 H 2-SCF.sub.3 17003 H 3-SCF.sub.3 17004 H 4-SCF.sub.3 17005 H 2-SEtF 17006 H 3-SEtF 17007 H 4-SEtF 17008 H 2-SPrF 17009 H 3-SPrF 17010 H 4-SPrF 17011 H 2-OMe, 4-OMe 17012 H 2-Me, 5-OH 17013 H 2-Me, 5-OMe 17014 H 2-Me, 5-OMeF 17015 H 2-Me, 5-OEtF 17016 H 2-Me, 5-OPrF 17017 H 2-Me, 4-OH 17018 H 2-Me, 4-OMe 17019 H 2-Me, 4-OMeF 17020 H 2-Me, 4-OCF.sub.3 17021 H 2-Me, 4-OEtF 17022 H 2-Me, 4-OPrF 17023 H 2-OH, 4-Me 17024 H 2-OMe, 4-Me 17025 H 2-OMeF, 4-Me 17026 H 2-OCF.sub.3, 4-Me 17027 H 2-OEtF, 4-Me 17028 H 2-OPrF, 4-Me 17029 H 2-Cl, 4-OH 17030 H 2-Cl, 4-OMe 17031 H 2-Cl, 4-OMeF 17032 H 2-Cl, 4-OCF.sub.3 17033 H 2-Cl, 4-OEtF 17034 H 2-Cl, 4-OPrF 17035 H 2-F, 4-F 17036 H 2-Cl, 4-Cl 17037 H 2-Cl, 4-F 17038 H 2-Cl, 4-NO.sub.2 17039 H 2-Cl, 4-NH.sub.2 17040 H 2-Cl, 4-NHMe 17041 H 2-Cl, 4-NMe, 17042 H 2-Cl, 4-NMe.sub.3OTf 17043 H 2-Cl, 4-NMe.sub.3I 17044 H 2-Cl, 5-F 17045 H 2-Cl, 5-NO.sub.2 17046 H 2-Cl, 5-NH.sub.2 17047 H 2-Cl, 5-NHMe 17048 H 2-Cl, 5-NMe.sub.2 17049 H 2-Cl, 5-NMe.sub.3OTf 17050 H 2-O, 5- NMe.sub.3I 17051 H 2-F, 4-Cl 17052 H 2-NO.sub.2, 4-Cl 17053 H 2-NH.sub.2, 4-Cl 17054 H 2-NHMe, 4-Cl 17055 H 2-NMe.sub.2, 4-O 17056 H 2-NMe.sub.3OTf, 4-Cl 17057 H 2-NMe.sub.3I, 4-Cl 17058 H 2-F, 5-Cl 17059 H 2-NO.sub.2, 5-Cl 17060 H 2-NH.sub.2, 5-Cl 17061 H 2-NHMe, 5-Cl 17062 H 2-NMe.sub.2, 5-Cl 17063 H 2-NMe.sub.3OTf, 5-Cl 17064 H 2-NMe.sub.3I, 5-Cl 17065 H 2-Br, 4-F 17066 H 2-Br, 4-NO.sub.2 17067 II 2-Br, 4-NH.sub.2 17068 H 2-Br, 4-NHMe 17069 H 2-Br, 4-NMe.sub.2 17070 H 2-Br, 4-NMe.sub.3OTf 17071 H 2-Br, 4-NMe.sub.31 17072 H 2-Br, 5-F 17073 H 2-Br, 5-NO.sub.2 17074 H 2-Br, 5-NH.sub.2 17075 H 2-Br, 5-NHMe 17076 H 2-Br, 5-NMe.sub.2 17077 II 2-Br, 5-NMe.sub.3OTf 17078 H 2-Br, 5-NMe.sub.3I 17079 H 2-F, 4-Br 17080 H 2-NO.sub.2, 4-Br 17081 H 2-NH.sub.2, 4-Br 17082 H 2-NHMe, 4-Br 17083 H 2-NMe.sub.2, 4-Br 17084 H 2-NMe.sub.3OTf, 4-Br 17085 FI 2-NMe.sub.3I, 4-Br 17086 H 2-I, 4-F 17087 H 2-I, 4-NO.sub.2 17088 H 2-I, 4-NH.sub.2 17089 H 2-I, 4-NHMe 17090 H 2-I, 4-NMe.sub.2 17091 H 2-I, 4-NMe.sub.3OTf 17092 H 2-I, 4-NMe.sub.3I 17093 H 2-F, 4-I 17094 H 2-NO.sub.2, 4-I 17095 14 2-NH.sub.2, 4-I 17096 H 2-NHMe, 4-I 17097 H 2-NMe.sub.2, 4-I 17098 H 2-NMe.sub.3OTf, 4-I 17099 H 2-NMe.sub.3I, 4-I 17100 H 2-Me, 3-F 17101 H 2-Me, 3-NO.sub.2 17102 H 2-Me, 3-NH.sub.2 17103 H 2-Me, 3-NHMe 17104 H 2-Me, 3-NMe.sub.2 17105 H 2-Me, 3-NMe.sub.3OTf 17106 H 2-Me, 3-NMe.sub.3I 17107 H 2-Me, 4-F 17108 H 2-Me, 4-NO.sub.2 17109 H 2-Me, 4-NH.sub.2 17110 H 2-Me, 4-NHMe 17111 H 2-Me, 4-NMe.sub.2 17112 H 2-Me, 4-NMe.sub.3OTf 17113 II 2-Me, 4-NMe.sub.3I 17114 H 2-Me, 5-F 17115 H 2-Me, 5-NO.sub.2 17116 H 2-Me, 5-NH.sub.2 17117 H 2-Me, 5-NHMe 17118 H 2-Me, 5-NMe.sub.2 17119 H 2-Me, 5-NMe.sub.3OTf 17120 H 2-Me, 5-NMe.sub.3I 17121 H 2-F, 4-Me 17122 H 2-NO.sub.2, 4-Me 17123 H 2-NH.sub.2, 4-Me 17124 H 2-NHMe, 4-Me 17125 H 2-NMe.sub.2, 4-Me 17126 H 2-NMe.sub.3, 4-Me 17127 H 2-NMe.sub.3OTf, 4-Me 17128 H 2-NMe.sub.3I, 4-Me 17129 H 2-SnMe.sub.3, 4-F 17130 H 2-SnMe.sub.3, 5-F 17131 H 2-F, 4-SnMe.sub.3 17132 H 2-Br, 6-Cl, 4-F 17133 H 2-Br, 6-Cl, 4-NO.sub.2 17134 H 2-Br, 6-Cl, 4-NI12 17135 H 2-Br, 6-Cl, 4-NHMe 17136 H 2-Br, 6-Cl, 4-NMe.sub.2 17137 H 2-Br, 6-Cl, 4-NMe.sub.3OTf 17138 H 2-Br, 6-Cl, 4-NMe.sub.3I 17139 H 2-Me, 6-Cl, 4-F 17140 H 2-SnMe.sub.3, 6-Cl, 4-F 17141 H 2-Cl, 4-Me 17142 H 2-Cl, 4-Br 17143 H 2-Cl, 4 SnMe.sub.3 17144 H 2-Br, 4-Cl 17145 H 2-SnMe.sub.3, 4-Cl 17146 H 2-Me, 4-Cl 17147 H 2-Br, 4-Br 17148 H 2-Br, 4-Me 17149 H 2-Br, 4-SnMe.sub.3 17150 H 2-SnMe.sub.3, 4-Br 17151 H 2-Me, 4-Br 17152 H 2-Me, 4-SnMe.sub.3 17153 H 2-SnMe.sub.3, 4-Me 17154 H 2-Me, 4-Me 17155 H 2-Et, 4-Br 17156 H 2-Et, 4-SnMe.sub.3 17157 H 2-Et, 4-Me 17158 H 2-Me, 4-Me, 6-Me 17159 H 2-Me, 4-Br, 6-Me

17160 H 2-Me, 4-SnMe.sub.3, 6-Me 17161 H 2-Et, 6-Me 17162 H 2-Br, 4-i-Pr 17163 H 2-SnMe.sub.3, 4-i-Pr 17164 H 2-Me, 4-i-Pr 17165 H 2-Br, 4-Br, 6-Br 17166 H 2-Br, 4-Me, 6-Br 17167 H 2-Br, 4-SnMe.sub.3, 6-Br 17168 H 2-SnMe.sub.3, 4-Br, 6-Br 17169 H 2-Br, 4-Br, 6-Me 17170 H 2-Br, 4-CF.sub.3, 6-Br 17171 H 2-Br, 4-Br, 6-CF.sub.3 17172 H 2-CF.sub.3, 4-CF.sub.3 17173 H 2-Cl, 4-CF.sub.3 17174 H 2-CF.sub.3, 4-Cl 17175 H 2-Br, 4-CF.sub.3 17176 H 2-SnMe.sub.3, 4-CF.sub.3 17177 H 2-Me, 4-CF.sub.3 17178 H 2-CF.sub.3, 4-Br 17179 H 2-CF.sub.3, 4-SnMe.sub.3 17180 H 2-CF.sub.3, 4-Me 17181 H 2-Br, 4-OH 17182 H 2-Br, 4-OMe 17183 H 2-Br, 4-OMeF 17184 II 2-Br, 4-OCF.sub.3 17185 H 2-Br, 4-OEtF 17186 H 2-Br, 4-OPrF 17187 H 2-OH, 4-Br 17188 H 2-OMe, 4-Br 17189 H 2-OMeF, 4-Br 17190 H 2-OCF.sub.3, 4-Br 17191 H 2-OEtF, 4-Br 17192 H 2-OPrF, 4-Br 17193 H 2-I, 4-OH 17194 H 2-I, 4-OMe 17195 H 2-I, 4-OMeF 17196 H 2-I, 4-OCF.sub.3 17197 H 2-I, 4-OEtF 17198 H 2-I, 4-OPrF 17199 II 2-OH, 4-I 17200 H 2-OMe, 4-I 17201 H 2-OMeF, 4-I 17202 H 2-OCF.sub.3, 4-I 17203 H 2-OEtF, 4-I 17204 H 2-OPrF, 4-I 17205 H 2-SnMe.sub.3, 4-OH 17206 H 2-SnMe.sub.3, 4-OMe 17207 H 2-SnMe.sub.3, 4-OMeF 17208 H 2-SnMe.sub.3, 4-OCF.sub.3 17209 H 2-SnMe.sub.3, 4-OEtF 17210 H 2-SnMe.sub.3, 4-OPrF 17211 H 2-OH, 4-SnMe.sub.3 17212 H 2-OMe, 4-SnMe.sub.3 17213 H 2-OMeF, 4-SnMe.sub.3 17214 H 2-OCF.sub.3, 4-SnMe.sub.3 17215 H 2-OEtF, 4-SnMe.sub.3 17216 H 2-OPrF, 4-SnMe.sub.3

Claims

1-24. (canceled)

25. A compound selected from the group consisting of: ##STR00098## and a pharmaceutically acceptable salt of any of the foregoing comprising a label selected from the group consisting of: .sup.2H, .sup.3H, .sup.11C, .sup.13N, .sup.14C, .sup.32Cl, .sup.13N, .sup.18F, .sup.75Br, .sup.76Br, .sup.123I, .sup.124I, .sup.125I, and .sup.131I wherein: R.sup.1 is selected from the group consisting of ##STR00099## R.sup.2 is selected from the group consisting of: H, alkyl, and haloalkyl; R.sup.4 is independently selected from the group consisting of: --H, --X, alkyl, haloalkyl, --OH, --O-alkyl, --O-haloalkyl, and --Sn(alkyl).sub.3, wherein o is 1, 2, or 3; each R.sup.9 are independently selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R.sup.10 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R.sup.11 is selected from the group consisting of: ##STR00100## R.sup.12 is selected from the group consisting of: H, --OH, --O-alkyl, alkyl, X, haloalkyl, and heteroalkyl; R.sup.13 is selected from the group consisting of: H, alkyl, haloalkyl, and heteroalkyl; R.sup.14 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; R.sup.15 is selected from the group consisting of: H, halogen, alkyl, haloalkyl, and heteroalkyl; X is a halogen; X.sup.2 is selected from the group consisting of: H, alkyl, --X, and --Sn(alkyl).sub.3; y is selected from the group consisting of: 1 or 2; and z is selected from the group consisting of: 1, 2, or 3.

26. The compound of formula (3), according to claim 25, wherein R.sup.9 is H and R.sup.10 is methyl, and a pharmaceutically acceptable salt of any of the foregoing.

27. The compound of formula (4), according to claim 25, wherein R.sup.9 is H and R.sup.10 is methyl, and a pharmaceutically acceptable salt of any of the foregoing.

28. The compound of formula (5), according to claim 25, wherein R.sup.9 is H and R.sup.10 is methyl, and a stereoisomer thereof, and a pharmaceutically acceptable salt of any of the foregoing.

29. A pharmaceutical composition comprising a compound of any one of claim 25 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.