U.S. patent application number 13/747201 was filed with the patent office on 2013-10-17 for production of transgenic avians using improved retroviral vectors. The applicant listed for this patent is Alex J. Harvey, Jeffrey C. Rapp. Invention is credited to Alex J. Harvey, Jeffrey C. Rapp.
Application Number | 20130276153 13/747201 |
Document ID | / |
Family ID | 39644751 |
Filed Date | 2013-10-17 |
United States Patent Application | 20130276153 |
Kind Code | A1 |
Harvey; Alex J. ; et al. | October 17, 2013 |
A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.
Inventors: | Harvey; Alex J.; (Athens, GA) ; Rapp; Jeffrey C.; (Athens, GA) | ||||||||||
Applicant: |
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Family ID: | 39644751 | ||||||||||
Appl. No.: | 13/747201 | ||||||||||
Filed: | January 22, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13179281 | Jul 8, 2011 | 8383399 | ||
13747201 | ||||
11978360 | Oct 29, 2007 | |||
13179281 | ||||
11799253 | May 1, 2007 | |||
11978360 | ||||
11699257 | Jan 26, 2007 | 7541512 | ||
11799253 | ||||
11210165 | Aug 23, 2005 | |||
11699257 | ||||
60994203 | Sep 18, 2007 | |||
60930491 | May 16, 2007 | |||
60640203 | Dec 29, 2004 | |||
Current U.S. Class: | 800/4 ; 800/19 |
Current CPC Class: | C12N 2800/24 20130101; A01K 67/0275 20130101; C12N 15/8509 20130101; C12N 2015/8518 20130101; C12N 2740/11043 20130101; A01K 2217/052 20130101; A01K 67/0278 20130101; A01K 2207/15 20130101; C12N 2830/90 20130101; C07K 2319/30 20130101; C12N 7/00 20130101; A01K 2227/30 20130101; C12N 2830/15 20130101; C07K 14/56 20130101; A01K 2267/01 20130101; C12N 15/86 20130101; C12N 2830/008 20130101; C07K 14/70521 20130101 |
Class at Publication: | 800/4 ; 800/19 |
International Class: | C12N 15/85 20060101 C12N015/85 |
Sequence CWU 1
1
2919597DNAArtificial SequencepALV-SIN-4.2-Lys-IFNa-2B Vector
1gatcccccgt gctgcagaac cgagcggcta ttgacttctt gctcctagct cacggccatg
60gctgtgagga cattgcggga atgtgttgtt tcaatctgag tgatcacagt gagtctatac
120agaagaagtt ccagctaatg aaggaacatg tcaataagat cggcgtgaac
aacgacccaa 180tcggaagttg gctgcgagga ttattcggag gaataggaga
atgggccgta cacttgctga 240aaggactgct tttggggctt gtagttatct
tgttgctagt agtatgcttg ccttgccttt 300tgcaatgtgt atctagtagt
attcgaaaga tgattgataa ttcactcggc tatcgcgagg 360aatataaaaa
aattacagga ggcttataag cagcccgaaa gaagagcgta ggcgagttct
420tgtattccgt gtgatagctg gttggattgg taattgatcg gctggcacgc
ggaatatagg 480aggtcgctga atagtaaact tgtagacttg gctacagcat
agagtatctt ctgtagctct 540gatgactgct aggaaataat gctacggata
atgtggggag ggcaaggctt gcgaatcggg 600ttgtaacggg caaggcttga
ctgaggggac aatagcatgt ttaggcgaaa agcggggctt 660cggttgtacg
cggttaggag tcccctcagg atatagtagt ttcgcttttg catagggagg
720gggacggatt ggacgaacca ctgaattccg cattgcagag atattgtatt
taagtgccta 780gctcgataca ataaacgcca tttgaccatt caccacattg
gtgtgcacct gggttgatgg 840ccggaccgtt gattccctgr cgactacgag
cacatgcatg aagcagaagg cttcatttgg 900tgaccccgac gtgatcgtta
gggaatacgc gctcactggc cgtcgtttta caacgtcgtg 960actgggaaaa
ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca
1020gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg
cgcagcctga 1080atggcgaatg gaaattgtaa gcgttaatat tttgttaaaa
ttcgcgttaa atttttgtta 1140aatcagctca ttttttaacc aataggccga
aatcggcaaa atcccttata aatcaaaaga 1200atagaccgag atagggttga
gtgttgttcc agtttggaac aagagtccac tattaaagaa 1260cgtggactcc
aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga
1320accatcaccc taatcaagtt ttttggggtc gaggtgccgt aaagcactaa
atcggaaccc 1380taaagggagc ccccgattta gagcttgacg gggaaagccg
gcgaacgtgg cgagaaagga 1440agggaagaaa gcgaaaggag cgggcgctag
ggcgctggca agtgtagcgg tcacgctgcg 1500cgtaaccacc acacccgccg
cgcttaatgc gccgctacag ggcgcgtcag gtggcacttt 1560tcggggaaat
gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta
1620tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa
ggaagagtat 1680gagtattcaa catttccgtg tcgcccttat tccctttttt
gcggcatttt gccttcctgt 1740ttttgctcac ccagaaacgc tggtgaaagt
aaaagatgct gaagatcagt tgggtgcacg 1800agtgggttac atcgaactgg
atctcaacag cggtaagatc cttgagagtt ttcgccccga 1860agaacgtttt
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg
1920tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga
atgacttggt 1980tgagtactca ccagtcacag aaaagcatct tacggatggc
atgacagtaa gagaattatg 2040cagtgctgcc ataaccatga gtgataacac
tgcggccaac ttacttctga caacgatcgg 2100aggaccgaag gagctaaccg
cttttttgca caacatgggg gatcatgtaa ctcgccttga 2160tcgttgggaa
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc
2220tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta
ctctagcttc 2280ccggcaacaa ttaatagact ggatggaggc ggataaagtt
gcaggaccac ttctgcgctc 2340ggcccttccg gctggctggt ttattgctga
taaatctgga gccggtgagc gtgggtctcg 2400cggtatcatt gcagcactgg
ggccagatgg taagccctcc cgtatcgtag ttatctacac 2460gacggggagt
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc
2520actgattaag cattggtaac tgtcagacca agtttactca tatatacttt
agattgattt 2580aaaacttcat ttttaattta aaaggatcta ggtgaagatc
ctttttgata atctcatgac 2640caaaatccct taacgtgagt tttcgttcca
ctgagcgtca gaccccgtag aaaagatcaa 2700aggatcttct tgagatcctt
tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc 2760accgctacca
gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt
2820aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc
cgtagttagg 2880ccaccacttc aagaactctg tagcaccgcc tacatacctc
gctctgctaa tcctgttacc 2940agtggctgct gccagtggcg ataagtcgtg
tcttaccggg ttggactcaa gacgatagtt 3000accggataag gcgcagcggt
cgggctgaac ggggggttcg tgcacacagc ccagcttgga 3060gcgaacgacc
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct
3120tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa
caggagagcg 3180cacgagggag cttccagggg gaaacgcctg gtatctttat
agtcctgtcg ggtttcgcca 3240cctctgactt gagcgtcgat ttttgtgatg
ctcgtcaggg gggcggagcc tatggaaaaa 3300cgccagcaac gcggcctttt
tacggttcct ggccttttgc tggccttttg ctcacatgtt 3360ctttcctgcg
ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga
3420taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg
aagcggaaga 3480gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg
attcattaat gcagctggca 3540cgacaggttt cccgactgga aagcgggcag
tgagcgcaac gcaattaatg tgagttagct 3600cactcattag gcaccccagg
ctttacactt tatgcttccg gctcgtatgt tgtgtggaat 3660tgtgagcgga
taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc
3720attggtaatt gatcggctgg cacgcggaat ataggaggtc gctgaatagt
aaacttgtag 3780acttggctac agcatagagt atcttctgta gctctgatga
ctgctaggaa ataatgctac 3840ggataatgtg gggagggcaa ggcttgcgaa
tcgggttgta acgggcaagg cttgactgag 3900gggacaatag catgtttagg
cgaaaagcgg ggcttcggtt gtacgcggtt aggagtcccc 3960tcaggatata
gtagtttcgc ttttgcatag ggagggggaa atgtagtctt atgcaatact
4020cttgtagtct tgcaacatgc ttatgtaacg atgagttagc aacatgcctt
ataaggagag 4080aaaaagcacc gtgcatgccg attggtggga gtaaggtggt
atgatcgtgg tatgatcgtg 4140ccttgttagg aaggcaacag acgggtctaa
cacggattgg acgaaccact gaattccgca 4200ttgcagagat attgtattta
agtgcctagc tcgatacaat aaacgccatt tgaccattca 4260ccacattggt
gtgcacctgg gttgatggcc ggaccgttga ttccctgrcg actacgagca
4320catgcatgaa gcagaaggct tcatttggtg accccgacgt gatcgttagg
gaatagtggt 4380cggccacagg cggcgtggcg atcctgtcct catccgtctc
gcttattcgg ggagcggacg 4440atgaccctag tagagggggc tgcggcttag
gagggcagaa gctgagtggc gtcggaggga 4500gccctactgc agggggccaa
cataccctac cgagaactca gagagtcgtt ggaagacggg 4560aaggaagccc
gacgactgag cggtccaccc caggcgtgat tccggttgct ctgcgtgatt
4620ccggtcgccc ggtggatcaa gcatggaagc cgtcataaag gtgatttcgt
ccgcgtgtaa 4680gacctattgc gggaaaacct ctccttctaa gaaggaaata
ggggctatgt tgtccctgtt 4740acaaaaggaa gggttgctta cgtccccctc
agacttatat tccccggggt cctgggatcc 4800gataccgtcc ctatttttgt
gtttgcttca gcagccattt aattcttcag tgtcatcttg 4860ttctgttgat
gccactggaa caggattttc agcagtcttg caaagaacat ctagctgaaa
4920actttctgcc attcaatatt cttaccagtt cttcttgttt gaggtgagcc
ataaattact 4980agaacttcgt cactgacaag tttatgcatt ttattacttc
tattatgtac ttactttgac 5040ataacacaga cacgcacata ttttgctggg
atttccacag tgtctctgtg tccttcacat 5100ggttttactg tcatacttcc
gttataacct tggcaatctg cccagctgcc catcacaaga 5160aaagagattc
cttttttatt acttctcttc agccaataaa caaaatgtga gaagcccaaa
5220caagaacttg tggggcaggc tgccatcaag ggagagacag ctgaagggtt
gtgtagctca 5280atagaattaa gaaataataa agctgtgtca gacagttttg
cctgatttat acaggcacgc 5340cccaagccag agaggctgtc tgccaaggcc
accttgcagt ccttggtttg taagataagt 5400cataggtaac ttttctggtg
aattgcgtgg agaatcatga tggcagttct tgctgtttac 5460tatggtaaga
tgctaaaata ggagacagca aagtaacact tgctgctgta ggtgctctgc
5520tatccagaca gcgatggcac tcgcacacca agatgaggga tgctcccagc
tgacggatgc 5580tggggcagta acagtgggtc ccatgctgcc tgctcattag
catcacctca gccctcacca 5640gcccatcaga aggatcatcc caagctgagg
aaagttgctc atcttcttca catcatcaaa 5700cctttggcct gactgatgcc
tcccggatgc ttaaatgtgg tcactgacat ctttattttt 5760ctatgatttc
aagtcagaac ctccggatca ggagggaaca catagtggga atgtaccctc
5820agctccaagg ccagatcttc cttcaatgat catgcatgct acttaggaag
gtgtgtgtgt 5880gtgaatgtag aattgccttt gttatttttt cttcctgctg
tcaggaacat tttgaatacc 5940agagaaaaag aaaagtgctc ttcttggcat
gggaggagtt gtcacacttg caaaataaag 6000gatgcagtcc caaatgttca
taatctcagg gtctgaagga ggatcagaaa ctgtgtatac 6060aatttcaggc
ttctctgaat gcagcttttg aaagctgttc ctggccgagg cagtactagt
6120cagaaccctc ggaaacagga acaaatgtct tcaaggtgca gcaggaggaa
acaccttgcc 6180catcatgaaa gtgaataacc actgccgctg aaggaatcca
gctcctgttt gagcaggtgc 6240tgcacactcc cacactgaaa caacagttca
tttttatagg acttccagga aggatcttct 6300tcttaagctt cttaattatg
gtacatctcc agttggcaga tgactatgac tactgacagg 6360agaatgagga
actagctggg aatatttctg tttgaccacc atggagtcac ccatttcttt
6420actggtattt ggaaataata attctgaatt gcaaagcagg agttagcgaa
gatcttcatt 6480tcttccatgt tggtgacagc acagttctgg ctatgaaagt
ctgcttacaa ggaagaggat 6540aaaaatcata gggataataa atctaagttt
gaagacaatg aggttttagc tgcatttgac 6600atgaagaaat tgagacctct
actggatagc tatggtattt acgtgtcttt ttgcttagtt 6660acttattgac
cccagctgag gtcaagtatg aactcaggtc tctcgggcta ctggcatgga
6720ttgattacat acaactgtaa ttttagcagt gatttagggt ttatgagtac
ttttgcagta 6780aatcataggg ttagtaatgt taatctcagg gaaaaaaaaa
aaaagccaac cctgacagac 6840atcccagctc aggtggaaat caaggatcac
agctcagtgc ggtcccagag aacacaggga 6900ctcttctctt aggaccttta
tgtacagggc ctcaagataa ctgatgttag tcagaagact 6960ttccattctg
gccacagttc agctgaggca atcctggaat tttctctccg ctgcacagtt
7020ccagtcatcc cagtttgtac agttctggca ctttttgggt caggccgtga
tccaaggagc 7080agaagttcca gctatggtca gggagtgcct gaccgtccca
actcactgca ctcaaacaaa 7140ggcgaaacca caagagtggc ttttgttgaa
attgcagtgt ggcccagagg ggctgcacca 7200gtactggatt gaccacgagg
caacattaat cctcagcaag tgcaatttgc agccattaaa 7260ttgaactaac
tgatactaca atgcaatcag tatcaacaag tggtttggct tggaagatgg
7320agtctagggg ctctacagga gtagctactc tctaatggag ttgcattttg
aagcaggaca 7380ctgtgaaaag ctggcctcct aaagaggctg ctaaacatta
gggtcaattt tccagtgcac 7440tttctgaagt gtctgcagtt ccccatgcaa
agctgcccaa acatagcact tccaattgaa 7500tacaattata tgcaggcgta
ctgcttcttg ccagcactgt ccttctcaaa tgaactcaac 7560aaacaatttc
aaagtctagt agaaagtaac aagctttgaa tgtcattaaa aagtatatct
7620gctttcagta gttcagctta tttatgccca ctagaaacat cttgtacaag
ctgaacactg 7680gggctccaga ttagtggtaa aacctacttt atacaatcat
agaatcatag aatggcctgg 7740gttggaaggg accccaagga tcatgaagat
ccaacacccc cgccacaggc agggccacca 7800acctccagat ctggtactag
accaggcagc ccagggctcc atccaacctg gccatgaaca 7860cctccaggga
tggagcatcc acaacctctc tgggcagcct gtgccagcac ctcaccaccc
7920tctctgtgaa gaacttttcc ctgacatcca atctaagcct tccctccttg
aggttagatc 7980cactccccct tgtgctatca ctgtctactc ttgtaaaaag
ttgattctcc tcctttttgg 8040aaggttgcaa tgaggtctcc ttgcagcctt
cttctcttct gcaggatgaa caagcccagc 8100tccctcagcc tgtctttata
ggagaggtgc tccagccctc tgatcatctt tgtggccctc 8160ctctggaccc
gctccaagag ctccacatct ttcctgtact gggggcccca ggcctgaatg
8220cagtactcca gatggggcct caaaagagca gagtaaagag ggacaatcac
cttcctcacc 8280ctgctggcca gccctcttct gatggagccc tggatacaac
tggctttctg agctgcaact 8340tctccttatc agttccacta ttaaaacagg
aacaatacaa caggtgctga tggccagtgc 8400agagtttttc acacttcttc
atttcggtag atcttagatg aggaacgttg aagttgtgct 8460tctgcgtgtg
cttcttcctc ctcaaatact cctgcctgat acctcacccc acctgccact
8520gaatggctcc atggccccct gcagccaggg ccctgatgaa cccggcactg
cttcagatgc 8580tgtttaatag cacagtatga ccaagttgca cctatgaata
cacaaacaat gtgttgcatc 8640cttcagcact tgagaagaag agccaaattt
gcattgtcag gaaatggttt agtaattctg 8700ccaattaaaa cttgtttatc
taccatggct gtttttatgg ctgttagtag tggtacactg 8760atgatgaaca
atggctatgc agtaaaatca agactgtaga tattgcaaca gactataaaa
8820ttcctctgtg gcttagccaa tgtggtactt cccacattgt ataagaaatt
tggcaagttt 8880agagcaatgt ttgaagtgtt gggaaatttc tgtatactca
agagggcgtt tttgacaact 8940gtagaacaga ggaatcaaaa gggggtggga
ggaagttaaa agaagaggca ggtgcaagag 9000agcttgcagt cccgctgtgt
gtacgacact ggcaacatga ggtctttgct aatcttggtg 9060ctttgcttcc
tgcccctggc tgccttaggg tgcgatctgc ctcagaccca cagcctgggc
9120agcaggagga ccctgatgct gctggctcag atgaggagaa tcagcctgtt
tagctgcctg 9180aaggataggc acgattttgg ctttcctcaa gaggagtttg
gcaaccagtt tcagaaggct 9240gagaccatcc ctgtgctgca cgagatgatc
cagcagatct ttaacctgtt tagcaccaag 9300gatagcagcg ctgcttggga
tgagaccctg ctggataagt tttacaccga gctgtaccag 9360cagctgaacg
atctggaggc ttgcgtgatc cagggcgtgg gcgtgaccga gacccctctg
9420atgaaggagg atagcatcct ggctgtgagg aagtactttc agaggatcac
cctgtacctg 9480aaggagaaga agtacagccc ctgcgcttgg gaagtcgtga
gggctgagat catgaggagc 9540tttagcctga gcaccaacct gcaagagagc
ttgaggtcta aggagtaaaa agtctag 9597228DNAArtificial SequencePrimer
ALV-SIN-1 2atgcgcgcat tggtaattga tcggctgg 28380DNAArtificial
SequencePrimer ALV-SIN-2 3atatgcggcc gcggtaccgc ccgggcatcg
atatcaagct tacggttcac taaacgagct 60ctgcttatat agacctccca
80459DNAArtificial SequencePrimer ALV-SIN-3 4atatgcggcc gcgtcgacgg
ccggccagat ctgctgagcc ggtcgctacc attaccagt 59528DNAArtificial
SequencePrimer ALV-SIN-4 5atacgcgtat tccctaacga tcacgtcg
28621DNAArtificial SequencePrimer ALV-SIN-5 6ctgaagtgta aggaatgtaa
g 21730DNAArtificial SequencePrimer ALV-SIN-6 7gcgcgtctca
tccccctccc tatgcaaaag 30837DNAArtificial SequencePrimer ALV-SIN-7
8gggcgtctca gggacggatt ggacgaacca ctgaatt 37920DNAArtificial
SequencePrimer ALV-SIN-8 9ttagtgcttt acggcacctc 201038DNAArtificial
SequencePrimer ALV-SIN-9 10gacggatccg ataccgtccc tatttttgtg
tttgcttc 381130DNAArtificial SequencePrimer ALV-SIN-10 11taacggatcc
tagacttttt actccttaga 301211945DNAArtificial SequenceProximal
promoter and lysozyme signal peptide 12tgccgccttc tttgatattc
actctgttgt atttcatctc ttcttgccga tgaaaggata 60taacagtctg tataacagtc
tgtgaggaaa tacttggtat ttcttctgat cagtgttttt 120ataagtaatg
ttgaatattg gataaggctg tgtgtccttt gtcttgggag acaaagccca
180cagcaggtgg tggttggggt ggtggcagct cagtgacagg agaggttttt
ttgcctgttt 240tttttttttt tttttttttt aagtaaggtg ttcttttttc
ttagtaaatt ttctactgga 300ctgtatgttt tgacaggtca gaaacatttc
ttcaaaagaa gaaccttttg gaaactgtac 360agcccttttc tttcattccc
tttttgcttt ctgtgccaat gcctttggtt ctgattgcat 420tatggaaaac
gttgatcgga acttgaggtt tttatttata gtgtggcttg aaagcttgga
480tagctgttgt tacacgagat accttattaa gtttaggcca gcttgatgct
ttattttttc 540cctttgaagt agtgagcgtt ctctggtttt tttcctttga
aactggtgag gcttagattt 600ttctaatggg attttttacc tgatgatcta
gttgcatacc caaatgcttg taaatgtttt 660cctagttaac atgttgataa
cttcggattt acatgttgta tatacttgtc atctgtgttt 720ctagtaaaaa
tatatggcat ttatagaaat acgtaattcc tgatttcctt tttttttatc
780tctatgctct gtgtgtacag gtcaaacaga cttcactcct atttttattt
atagaatttt 840atatgcagtc tgtcgttggt tcttgtgttg taaggataca
gccttaaatt tcctagagcg 900atgctcagta aggcgggttg tcacatgggt
tcaaatgtaa aacgggcacg tttggctgct 960gccttcccga gatccaggac
actaaactgc ttctgcactg aggtataaat cgcttcagat 1020cccagggaag
tgcagatcca cgtgcatatt cttaaagaag aatgaatact ttctaaaata
1080ttttggcata ggaagcaagc tgcatggatt tgtttgggac ttaaattatt
ttggtaacgg 1140agtgcatagg ttttaaacac agttgcagca tgctaacgag
tcacagcgtt tatgcagaag 1200tgatgcctgg atgcctgttg cagctgttta
cggcactgcc ttgcagtgag cattgcagat 1260aggggtgggg tgctttgtgt
cgtgttccca cacgctgcca cacagccacc tcccggaaca 1320catctcacct
gctgggtact tttcaaacca tcttagcagt agtagatgag ttactatgaa
1380acagagaagt tcctcagttg gatattctca tgggatgtct tttttcccat
gttgggcaaa 1440gtatgataaa gcatctctat ttgtaaatta tgcacttgtt
agttcctgaa tcctttctat 1500agcaccactt attgcagcag gtgtaggctc
tggtgtggcc tgtgtctgtg cttcaatctt 1560ttaaagcttc tttggaaata
cactgacttg attgaagtct cttgaagata gtaaacagta 1620cttacctttg
atcccaatga aatcgagcat ttcagttgta aaagaattcc gcctattcat
1680accatgtaat gtaattttac acccccagtg ctgacacttt ggaatatatt
caagtaatag 1740actttggcct caccctcttg tgtactgtat tttgtaatag
aaaatatttt aaactgtgca 1800tatgattatt acattatgaa agagacattc
tgctgatctt caaatgtaag aaaatgagga 1860gtgcgtgtgc ttttataaat
acaagtgatt gcaaattagt gcaggtgtcc ttaaaaaaaa 1920aaaaaaaaag
taatataaaa aggaccaggt gttttacaag tgaaatacat tcctatttgg
1980taaacagtta catttttatg aagattacca gcgctgctga ctttctaaac
ataaggctgt 2040attgtcttcc tgtaccattg catttcctca ttcccaattt
gcacaaggat gtctgggtaa 2100actattcaag aaatggcttt gaaatacagc
atgggagctt gtctgagttg gaatgcagag 2160ttgcactgca aaatgtcagg
aaatggatgt ctctcagaat gcccaactcc aaaggatttt 2220atatgtgtat
atagtaagca gtttcctgat tccagcaggc caaagagtct gctgaatgtt
2280gtgttgccgg agacctgtat ttctcaacaa ggtaagatgg tatcctagca
actgcggatt 2340ttaatacatt ttcagcagaa gtacttagtt aatctctacc
tttagggatc gtttcatcat 2400ttttagatgt tatacttgaa atactgcata
acttttagct ttcatgggtt cctttttttc 2460agcctttagg agactgttaa
gcaatttgct gtccaacttt tgtgttggtc ttaaactgca 2520atagtagttt
accttgtatt gaagaaataa agaccatttt tatattaaaa aatacttttg
2580tctgtcttca ttttgacttg tctgatatcc ttgcagtgcc cattatgtca
gttctgtcag 2640atattcagac atcaaaactt aacgtgagct cagtggagtt
acagctgcgg ttttgatgct 2700gttattattt ctgaaactag aaatgatgtt
gtcttcatct gctcatcaaa cacttcatgc 2760agagtgtaag gctagtgaga
aatgcataca tttattgata cttttttaaa gtcaactttt 2820tatcagattt
ttttttcatt tggaaatata ttgttttcta gactgcatag cttctgaatc
2880tgaaatgcag tctgattggc atgaagaagc acagcactct tcatcttact
taaacttcat 2940tttggaatga aggaagttaa gcaagggcac aggtccatga
aatagagaca gtgcgctcag 3000gagaaagtga acctggattt ctttggctag
tgttctaaat ctgtagtgag gaaagtaaca 3060cccgattcct tgaaagggct
ccagctttaa tgcttccaaa ttgaaggtgg caggcaactt 3120ggccactggt
tatttactgc attatgtctc agtttcgcag ctaacctggc ttctccacta
3180ttgagcatgg actatagcct ggcttcagag gccaggtgaa ggttgggatg
ggtggaagga 3240gtgctgggct gtggctgggg ggactgtggg gactccaagc
tgagcttggg gtgggcagca 3300cagggaaaag tgtgggtaac tatttttaag
tactgtgttg caaacgtctc atctgcaaat 3360acgtagggtg tgtactctcg
aagattaaca gtgtgggttc agtaatatat ggatgaattc 3420acagtggaag
cattcaaggg tagatcatct aacgacacca gatcatcaag ctatgattgg
3480aagcggtatc agaagagcga ggaaggtaag cagtcttcat atgttttccc
tccacgtaaa 3540gcagtctggg aaagtagcac cccttgagca gagacaagga
aataattcag gagcatgtgc 3600taggagaact ttcttgctga attctacttg
caagagcttt gatgcctggc ttctggtgcc 3660ttctgcagca cctgcaaggc
ccagagcctg tggtgagctg gagggaaaga ttctgctcaa 3720gtccaagctt
cagcaggtca ttgtctttgc ttcttccccc agcactgtgc agcagagtgg
3780aactgatgtc gaagcctcct gtccactacc tgttgctgca ggcagactgc
tctcagaaaa 3840agagagctaa ctctatgcca tagtctgaag gtaaaatggg
ttttaaaaaa gaaaacacaa 3900aggcaaaacc ggctgcccca tgagaagaaa
gcagtggtaa acatggtaga aaaggtgcag 3960aagcccccag gcagtgtgac
aggcccctcc tgccacctag aggcgggaac aagcttccct 4020gcctagggct
ctgcccgcga agtgcgtgtt tctttggtgg gttttgtttg gcgtttggtt
4080ttgagattta gacacaaggg aagcctgaaa ggaggtgttg ggcactattt
tggtttgtaa 4140agcctgtact tcaaatatat attttgtgag ggagtgtagc
gaattggcca atttaaaata 4200aagttgcaag agattgaagg ctgagtagtt
gagagggtaa cacgtttaat gagatcttct 4260gaaactactg
cttctaaaca cttgtttgag tggtgagacc ttggataggt gagtgctctt
4320gttacatgtc tgatgcactt gcttgtcctt ttccatccac atccatgcat
tccacatcca 4380cgcatttgtc acttatccca tatctgtcat atctgacata
cctgtctctt cgtcacttgg 4440tcagaagaaa cagatgtgat aatccccagc
cgccccaagt ttgagaagat ggcagttgct 4500tctttccctt tttcctgcta
agtaaggatt ttctcctggc tttgacacct cacgaaatag 4560tcttcctgcc
ttacattctg ggcattattt caaatatctt tggagtgcgc tgctctcaag
4620tttgtgtctt cctactctta gagtgaatgc tcttagagtg aaagagaagg
aagagaagat 4680gttggccgca gttctctgat gaacacacct ctgaataatg
gccaaaggtg ggtgggtttc 4740tctgaggaac gggcagcgtt tgcctctgaa
agcaaggagc tctgcggagt tgcagttatt 4800ttgcaactga tggtggaact
ggtgcttaaa gcagattccc taggttccct gctacttctt 4860ttccttcttg
gcagtcagtt tatttctgac agacaaacag ccacccccac tgcaggctta
4920gaaagtatgt ggctctgcct gggtgtgtta cagctctgcc ctggtgaaag
gggattaaaa 4980cgggcaccat tcatcccaaa caggatcctc attcatggat
caagctgtaa ggaacttggg 5040ctccaacctc aaaacattaa ttggagtacg
aatgtaatta aaactgcatt ctcgcattcc 5100taagtcattt agtctggact
ctgcagcatg taggtcggca gctcccactt tctcaaagac 5160cactgatgga
ggagtagtaa aaatggagac cgattcagaa caaccaacgg agtgttgccg
5220aagaaactga tggaaataat gcatgaattg tgtggtggac atttttttta
aatacataaa 5280ctacttcaaa tgaggtcgga gaaggtcagt gttttattag
cagccataaa accaggtgag 5340cgagtaccat ttttctctac aagaaaaacg
attctgagct ctgcgtaagt ataagttctc 5400catagcggct gaagctcccc
cctggctgcc tgccatctca gctggagtgc agtgccattt 5460ccttggggtt
tctctcacag cagtaatggg acaatacttc acaaaaattc tttcttttcc
5520tgtcatgtgg gatccctact gtgccctcct ggttttacgt taccccctga
ctgttccatt 5580cagcggtttg gaaagagaaa aagaatttgg aaataaaaca
tgtctacgtt atcacctcct 5640ccagcatttt ggtttttaat tatgtcaata
actggcttag atttggaaat gagagggggt 5700tgggtgtatt accgaggaac
aaaggaaggc ttatataaac tcaagtcttt tatttagaga 5760actggcaagc
tgtcaaaaac aaaaaggcct taccaccaaa ttaagtgaat agccgctata
5820gccagcaggg ccagcacgag ggatggtgca ctgctggcac tatgccacgg
cctgcttgtg 5880actctgagag caactgcttt ggaaatgaca gcacttggtg
caatttcctt tgtttcagaa 5940tgcgtagagc gtgtgcttgg cgacagtttt
tctagttagg ccacttcttt tttccttctc 6000tcctcattct cctaagcatg
tctccatgct ggtaatccca gtcaagtgaa cgttcaaaca 6060atgaatccat
cactgtagga ttctcgtggt gatcaaatct ttgtgtgagg tctataaaat
6120atggaagctt atttattttt cgttcttcca tatcagtctt ctctatgaca
attcacatcc 6180accacagcaa attaaaggtg aaggaggctg gtgggatgaa
gagggtcttc tagctttacg 6240ttcttccttg caaggccaca ggaaaatgct
gagagctgta gaatacagcc tggggtaaga 6300agttcagtct cctgctggga
cagctaaccg catcttataa ccccttctga gactcatctt 6360aggaccaaat
agggtctatc tggggttttt gttcctgctg ttcctcctgg aaggctatct
6420cactatttca ctgctcccac ggttacaaac caaagataca gcctgaattt
tttctaggcc 6480acattacata aatttgacct ggtaccaata ttgttctcta
tatagttatt tccttcccca 6540ctgtgtttaa ccccttaagg cattcagaac
aactagaatc atagaatggt ttggattgga 6600aggggcctta aacatcatcc
atttccaacc ctctgccatg ggctgcttgc cacccactgg 6660ctcaggctgc
ccagggcccc atccagcctg gccttgagca cctccaggga tggggcaccc
6720acagcttctc tgggcagcct gtgccaacac ctcaccactc tctgggtaaa
gaattctctt 6780ttaacatcta atctaaatct cttctctttt agtttaaagc
cattcctctt tttcccgttg 6840ctatctgtcc aagaaatgtg tattggtctc
cctcctgctt ataagcagga agtactggaa 6900ggctgcagtg aggtctcccc
acagccttct cttctccagg ctgaacaagc ccagctcctt 6960cagcctgtct
tcgtaggaga tcatcttagt ggccctcctc tggacccatt ccaacagttc
7020cacggctttc ttgtggagcc ccaggtctgg atgcagtact tcagatgggg
ccttacaaag 7080gcagagcaga tggggacaat cgcttacccc tccctgctgg
ctgcccctgt tttgatgcag 7140cccagggtac tgttggcctt tcaggctccc
agaccccttg ctgatttgtg tcaagctttt 7200catccaccag aacccacgct
tcctggttaa tacttctgcc ctcacttctg taagcttgtt 7260tcaggagact
tccattcttt aggacagact gtgttacacc tacctgccct attcttgcat
7320atatacattt cagttcatgt ttcctgtaac aggacagaat atgtattcct
ctaacaaaaa 7380tacatgcaga attcctagtg ccatctcagt agggttttca
tggcagtatt agcacatagt 7440caatttgctg caagtacctt ccaagctgcg
gcctcccata aatcctgtat ttgggatcag 7500ttaccttttg gggtaagctt
ttgtatctgc agagaccctg ggggttctga tgtgcttcag 7560ctctgctctg
ttctgactgc accattttct agatcaccca gttgttcctg tacaacttcc
7620ttgtcctcca tcctttccca gcttgtatct ttgacaaata caggcctatt
tttgtgtttg 7680cttcagcagc catttaattc ttcagtgtca tcttgttctg
ttgatgccac tggaacagga 7740ttttcagcag tcttgcaaag aacatctagc
tgaaaacttt ctgccattca atattcttac 7800cagttcttct tgtttgaggt
gagccataaa ttactagaac ttcgtcactg acaagtttat 7860gcattttatt
acttctatta tgtacttact ttgacataac acagacacgc acatattttg
7920ctgggatttc cacagtgtct ctgtgtcctt cacatggttt tactgtcata
cttccgttat 7980aaccttggca atctgcccag ctgcccatca caagaaaaga
gattcctttt ttattacttc 8040tcttcagcca ataaacaaaa tgtgagaagc
ccaaacaaga acttgtgggg caggctgcca 8100tcaagggaga gacagctgaa
gggttgtgta gctcaataga attaagaaat aataaagctg 8160tgtcagacag
ttttgcctga tttatacagg cacgccccaa gccagagagg ctgtctgcca
8220aggccacctt gcagtccttg gtttgtaaga taagtcatag gtaacttttc
tggtgaattg 8280cgtggagaat catgatggca gttcttgctg tttactatgg
taagatgcta aaataggaga 8340cagcaaagta acacttgctg ctgtaggtgc
tctgctatcc agacagcgat ggcactcgca 8400caccaagatg agggatgctc
ccagctgacg gatgctgggg cagtaacagt gggtcccatg 8460ctgcctgctc
attagcatca cctcagccct caccagccca tcagaaggat catcccaagc
8520tgaggaaagt tgctcatctt cttcacatca tcaaaccttt ggcctgactg
atgcctcccg 8580gatgcttaaa tgtggtcact gacatcttta tttttctatg
atttcaagtc agaacctccg 8640gatcaggagg gaacacatag tgggaatgta
ccctcagctc caaggccaga tcttccttca 8700atgatcatgc atgctactta
ggaaggtgtg tgtgtgtgaa tgtagaattg cctttgttat 8760tttttcttcc
tgctgtcagg aacattttga ataccagaga aaaagaaaag tgctcttctt
8820ggcatgggag gagttgtcac acttgcaaaa taaaggatgc agtcccaaat
gttcataatc 8880tcagggtctg aaggaggatc agaaactgtg tatacaattt
caggcttctc tgaatgcagc 8940ttttgaaagc tgttcctggc cgaggcagta
ctagtcagaa ccctcggaaa caggaacaaa 9000tgtcttcaag gtgcagcagg
aggaaacacc ttgcccatca tgaaagtgaa taaccactgc 9060cgctgaagga
atccagctcc tgtttgagca ggtgctgcac actcccacac tgaaacaaca
9120gttcattttt ataggacttc caggaaggat cttcttctta agcttcttaa
ttatggtaca 9180tctccagttg gcagatgact atgactactg acaggagaat
gaggaactag ctgggaatat 9240ttctgtttga ccaccatgga gtcacccatt
tctttactgg tatttggaaa taataattct 9300gaattgcaaa gcaggagtta
gcgaagatct tcatttcttc catgttggtg acagcacagt 9360tctggctatg
aaagtctgct tacaaggaag aggataaaaa tcatagggat aataaatcta
9420agtttgaaga caatgaggtt ttagctgcat ttgacatgaa gaaattgaga
cctctactgg 9480atagctatgg tatttacgtg tctttttgct tagttactta
ttgaccccag ctgaggtcaa 9540gtatgaactc aggtctctcg ggctactggc
atggattgat tacatacaac tgtaatttta 9600gcagtgattt agggtttatg
agtacttttg cagtaaatca tagggttagt aatgttaatc 9660tcagggaaaa
aaaaaaaaag ccaaccctga cagacatccc agctcaggtg gaaatcaagg
9720atcacagctc agtgcggtcc cagagaacac agggactctt ctcttaggac
ctttatgtac 9780agggcctcaa gataactgat gttagtcaga agactttcca
ttctggccac agttcagctg 9840aggcaatcct ggaattttct ctccgctgca
cagttccagt catcccagtt tgtacagttc 9900tggcactttt tgggtcaggc
cgtgatccaa ggagcagaag ttccagctat ggtcagggag 9960tgcctgaccg
tcccaactca ctgcactcaa acaaaggcga aaccacaaga gtggcttttg
10020ttgaaattgc agtgtggccc agaggggctg caccagtact ggattgacca
cgaggcaaca 10080ttaatcctca gcaagtgcaa tttgcagcca ttaaattgaa
ctaactgata ctacaatgca 10140atcagtatca acaagtggtt tggcttggaa
gatggagtct aggggctcta caggagtagc 10200tactctctaa tggagttgca
ttttgaagca ggacactgtg aaaagctggc ctcctaaaga 10260ggctgctaaa
cattagggtc aattttccag tgcactttct gaagtgtctg cagttcccca
10320tgcaaagctg cccaaacata gcacttccaa ttgaatacaa ttatatgcag
gcgtactgct 10380tcttgccagc actgtccttc tcaaatgaac tcaacaaaca
atttcaaagt ctagtagaaa 10440gtaacaagct ttgaatgtca ttaaaaagta
tatctgcttt cagtagttca gcttatttat 10500gcccactaga aacatcttgt
acaagctgaa cactggggct ccagattagt ggtaaaacct 10560actttataca
atcatagaat catagaatgg cctgggttgg aagggacccc aaggatcatg
10620aagatccaac acccccgcca caggcagggc caccaacctc cagatctggt
actagaccag 10680gcagcccagg gctccatcca acctggccat gaacacctcc
agggatggag catccacaac 10740ctctctgggc agcctgtgcc agcacctcac
caccctctct gtgaagaact tttccctgac 10800atccaatcta agccttccct
ccttgaggtt agatccactc ccccttgtgc tatcactgtc 10860tactcttgta
aaaagttgat tctcctcctt tttggaaggt tgcaatgagg tctccttgca
10920gccttcttct cttctgcagg atgaacaagc ccagctccct cagcctgtct
ttataggaga 10980ggtgctccag ccctctgatc atctttgtgg ccctcctctg
gacccgctcc aagagctcca 11040catctttcct gtactggggg ccccaggcct
gaatgcagta ctccagatgg ggcctcaaaa 11100gagcagagta aagagggaca
atcaccttcc tcaccctgct ggccagccct cttctgatgg 11160agccctggat
acaactggct ttctgagctg caacttctcc ttatcagttc cactattaaa
11220acaggaacaa tacaacaggt gctgatggcc agtgcagagt ttttcacact
tcttcatttc 11280ggtagatctt agatgaggaa cgttgaagtt gtgcttctgc
gtgtgcttct tcctcctcaa 11340atactcctgc ctgatacctc accccacctg
ccactgaatg gctccatggc cccctgcagc 11400cagggccctg atgaacccgg
cactgcttca gatgctgttt aatagcacag tatgaccaag 11460ttgcacctat
gaatacacaa acaatgtgtt gcatccttca gcacttgaga agaagagcca
11520aatttgcatt gtcaggaaat ggtttagtaa ttctgccaat taaaacttgt
ttatctacca 11580tggctgtttt tatggctgtt agtagtggta cactgatgat
gaacaatggc tatgcagtaa 11640aatcaagact gtagatattg caacagacta
taaaattcct ctgtggctta gccaatgtgg 11700tacttcccac attgtataag
aaatttggca agtttagagc aatgtttgaa gtgttgggaa 11760atttctgtat
actcaagagg gcgtttttga caactgtaga acagaggaat caaaaggggg
11820tgggaggaag ttaaaagaag aggcaggtgc aagagagctt gcagtcccgc
tgtgtgtacg 11880acactggcaa catgaggtct ttgctaatct tggtgctttg
cttcctgccc ctggctgcct 11940taggg 119451329DNAArtificial SequenceBAC
26 Primer-1 13gcggaattca aagaagaaag ctgaaaaac 291429DNAArtificial
SequenceBAC 26 Primer-2 14gcgggtacct tcaaatacta caagtgaaa
291533DNAArtificial SequenceBAC 26-OV Primer 1 15ggcctcgagt
caagttctga gtaggtttta gtg 331641DNAArtificial SequenceBAC 26-OV
Primer 2 16gcgcgtctct gtctagagca aacagcagaa cagtgaaaat g
411750DNAArtificial SequenceCTLA-4-Fc Primer 1 17gcgcgtctca
agacaactca gagttcacca tgggtgtact gctcacacag 501829DNAArtificial
SequenceCTLA-4-Fc Primer 2 18ggcccgggag ttttgtcaga agatttggg
291911868DNAArtificial SequencepSIN-OV-3.5-I-CTLA4-inv Vector
19aattgctaga ctaggatccc ccgtgctgca gaaccgagcg gctattgact tcttgctcct
60agctcacggc catggctgtg aggacattgc gggaatgtgt tgtttcaatc tgagtgatca
120cagtgagtct atacagaaga agttccagct aatgaaggaa catgtcaata
agatcggcgt 180gaacaacgac ccaatcggaa gttggctgcg aggattattc
ggaggaatag gagaatgggc 240cgtacacttg ctgaaaggac tgcttttggg
gcttgtagtt atcttgttgc tagtagtatg 300cttgccttgc cttttgcaat
gtgtatctag tagtattcga aagatgattg ataattcact 360cggctatcgc
gaggaatata aaaaaattac aggaggctta taagcagccc gaaagaagag
420cgtaggcgag ttcttgtatt ccgtgtgata gctggttgga ttggtaattg
atcggctggc 480acgcggaata taggaggtcg ctgaatagta aacttgtaga
cttggctaca gcatagagta 540tcttctgtag ctctgatgac tgctaggaaa
taatgctacg gataatgtgg ggagggcaag 600gcttgcgaat cgggttgtaa
cgggcaaggc ttgactgagg ggacaatagc atgtttaggc 660gaaaagcggg
gcttcggttg tacgcggtta ggagtcccct caggatatag tagtttcgct
720tttgcatagg gagggggacg gattggacga accactgaat tccgcattgc
agagatattg 780tatttaagtg cctagctcga tacaataaac gccatttgac
cattcaccac attggtgtgc 840acctgggttg atggccggac cgttgattcc
ctgrcgacta cgagcacatg catgaagcag 900aaggcttcat ttggtgaccc
cgacgtgatc gttagggaat acgcgctcac tggccgtcgt 960tttacaacgt
cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca
1020tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc
cttcccaaca 1080gttgcgcagc ctgaatggcg aatggaaatt gtaagcgtta
atattttgtt aaaattcgcg 1140ttaaattttt gttaaatcag ctcatttttt
aaccaatagg ccgaaatcgg caaaatccct 1200tataaatcaa aagaatagac
cgagataggg ttgagtgttg ttccagtttg gaacaagagt 1260ccactattaa
agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat
1320ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg
ccgtaaagca 1380ctaaatcgga accctaaagg gagcccccga tttagagctt
gacggggaaa gccggcgaac 1440gtggcgagaa aggaagggaa gaaagcgaaa
ggagcgggcg ctagggcgct ggcaagtgta 1500gcggtcacgc tgcgcgtaac
caccacaccc gccgcgctta atgcgccgct acagggcgcg 1560tcaggtggca
cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata
1620cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca
ataatattga 1680aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc
ttattccctt ttttgcggca 1740ttttgccttc ctgtttttgc tcacccagaa
acgctggtga aagtaaaaga tgctgaagat 1800cagttgggtg cacgagtggg
ttacatcgaa ctggatctca acagcggtaa gatccttgag 1860agttttcgcc
ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc
1920gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat
acactattct 1980cagaatgact tggttgagta ctcaccagtc acagaaaagc
atcttacgga tggcatgaca 2040gtaagagaat tatgcagtgc tgccataacc
atgagtgata acactgcggc caacttactt 2100ctgacaacga tcggaggacc
gaaggagcta accgcttttt tgcacaacat gggggatcat 2160gtaactcgcc
ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt
2220gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac
tggcgaacta 2280cttactctag cttcccggca acaattaata gactggatgg
aggcggataa agttgcagga 2340ccacttctgc gctcggccct tccggctggc
tggtttattg ctgataaatc tggagccggt 2400gagcgtgggt ctcgcggtat
cattgcagca ctggggccag atggtaagcc ctcccgtatc 2460gtagttatct
acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct
2520gagataggtg cctcactgat taagcattgg taactgtcag accaagttta
ctcatatata 2580ctttagattg atttaaaact tcatttttaa tttaaaagga
tctaggtgaa gatccttttt 2640gataatctca tgaccaaaat cccttaacgt
gagttttcgt tccactgagc gtcagacccc 2700gtagaaaaga tcaaaggatc
ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 2760caaacaaaaa
aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact
2820ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt
ccttctagtg 2880tagccgtagt taggccacca cttcaagaac tctgtagcac
cgcctacata cctcgctctg 2940ctaatcctgt taccagtggc tgctgccagt
ggcgataagt cgtgtcttac cgggttggac 3000tcaagacgat agttaccgga
taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 3060cagcccagct
tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga
3120gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag
cggcagggtc 3180ggaacaggag agcgcacgag ggagcttcca gggggaaacg
cctggtatct ttatagtcct 3240gtcgggtttc gccacctctg acttgagcgt
cgatttttgt gatgctcgtc aggggggcgg 3300agcctatgga aaaacgccag
caacgcggcc tttttacggt tcctggcctt ttgctggcct 3360tttgctcaca
tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc
3420tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga
gtcagtgagc 3480gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc
ccgcgcgttg gccgattcat 3540taatgcagct ggcacgacag gtttcccgac
tggaaagcgg gcagtgagcg caacgcaatt 3600aatgtgagtt agctcactca
ttaggcaccc caggctttac actttatgct tccggctcgt 3660atgttgtgtg
gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat
3720tacgccaagc gcgcattggt aattgatcgg ctggcacgcg gaatatagga
ggtcgctgaa 3780tagtaaactt gtagacttgg ctacagcata gagtatcttc
tgtagctctg atgactgcta 3840ggaaataatg ctacggataa tgtggggagg
gcaaggcttg cgaatcgggt tgtaacgggc 3900aaggcttgac tgaggggaca
atagcatgtt taggcgaaaa gcggggcttc ggttgtacgc 3960ggttaggagt
cccctcagga tatagtagtt tcgcttttgc atagggaggg ggaaatgtag
4020tcttatgcaa tactcttgta gtcttgcaac atgcttatgt aacgatgagt
tagcaacatg 4080ccttataagg agagaaaaag caccgtgcat gccgattggt
gggagtaagg tggtatgatc 4140gtggtatgat cgtgccttgt taggaaggca
acagacgggt ctaacacgga ttggacgaac 4200cactgaattc cgcattgcag
agatattgta tttaagtgcc tagctcgata caataaacgc 4260catttgacca
ttcaccacat tggtgtgcac ctgggttgat ggccggaccg ttgattccct
4320grcgactacg agcacatgca tgaagcagaa ggcttcattt ggtgaccccg
acgtgatcgt 4380tagggaatag tggtcggcca caggcggcgt ggcgatcctg
tcctcatccg tctcgcttat 4440tcggggagcg gacgatgacc ctagtagagg
gggctgcggc ttaggagggc agaagctgag 4500tggcgtcgga gggagcccta
ctgcaggggg ccaacatacc ctaccgagaa ctcagagagt 4560cgttggaaga
cgggaaggaa gcccgacgac tgagcggtcc accccaggcg tgattccggt
4620tgctctgcgt gattccggtc gcccggtgga tcaagcatgg aagccgtcat
aaaggtgatt 4680tcgtccgcgt gtaagaccta ttgcgggaaa acctctcctt
ctaagaagga aataggggct 4740atgttgtccc tgttacaaaa ggaagggttg
cttacgtccc cctcagactt atattccccg 4800gggtcctggg atcccattac
cgcggcgctc tctcagcggg ctatggtact tggaaaatcg 4860ggagagttaa
aaacctgggg attggttttg ggggcattga aggcggctcg agatccggta
4920ccttcaaata ctacaagtga aaagtgtttg cttaaacatg tttttattat
gattaaagga 4980acaaaagagc acattcacaa gacccattac atatgggtac
aaggaaaaca atttgaatag 5040taatatacca tatttgccaa cataccatga
ttgagtcaaa gtttagggag aaatgtgaat 5100tataagattt ttataatgca
tctttaggaa gtcaggaaga gccttgtagt atcaggaaca 5160cagagaacaa
gcaattgcct tgtcagcata ggaatggttg gtgacagttg ataatttaat
5220ctgagagatt ttgagtgact aattctggag cagcttggtc atacagatat
ctggcttaat 5280tggaaggctg catttttccc ccataaacct tctgctgatg
tatcaggttg catttttcag 5340tgtgatgact cagtactgtg agtccaattt
cattccctta agccttcatc catgagttac 5400cagtattact ctgtgtaaag
gaaaagtgaa ttgcacctgt tctcacagtg taatttcttt 5460ctgatttttt
ttctagatta agctccagct tttatgaagt ctggatgcag cagataacat
5520acttttcatt ttacccctga tactacagtg ctctgggtct tgttggaagg
gacagagttt 5580ttcagctttc ttctttgaat tcctcattta cccggagaca
gggagaggct cttctgcgtg 5640tagtggttgt gcagagcctc atgcatcacg
gagcatgaga agacgttccc ctgctgccac 5700ctgctcttgt ccacggtgag
cttgctgtag aggaagaagg agccgtcgga gtccagcacg 5760ggaggcgtgg
tcttgtagtt gttctccggc tgcccattgc tctcccactc cacggcgatg
5820tcgctgggat agaagccttt gaccaggcag gtcaggctga cctggttctt
ggtcagctca 5880tcccgggatg ggggcagggt gtacacctgt ggttctcggg
gctgcccttt ggctttggag 5940atggttttct cgatgggggc tgggagggct
ttgttggaga ccttgcactt gtactccttg 6000ccattcagcc agtcctggtg
caggacggtg aggacgctga ccacccggta cgtgctgttg 6060tactgctcct
cccgcggctt tgtcttggca ttatgcacct ccacgccgtc cacgtaccag
6120ttgaacttga cctcagggtc ttcgtggctc acgtccacca ccacgcatgt
gacctcaggg 6180gtccgggaga tcatgagggt gtccttgggt tttgggggga
agaggaagac tgacgatccc 6240cccaggagtt caggtgctgg ggacggtggg
gatgtgtgag ttttgtcaga agatttgggc 6300tcctgatcag aatctgggca
cggttctgga tcaattacat aaatctgggt tccgttgcct 6360atgcccaggt
agtatggcgg tgggtacatg agctccacct tgcagatgta gagtcccgtg
6420tccatggccc tcagtccttg gatagtgagg ttcacttgat ttccactgga
ggtgcccgtg 6480cagatggaat catctaggaa ggtcaactca ttccccatca
tgtaggttgc cgcacagact 6540tcagtcacct ggctgtcagc ctgccgaagc
actgtcaccc ggacctcagt ggctttgcct 6600ggagatgcat actcacacac
aaagctrgcg atgcctcggc tgctggccag taccacagca
6660ggctgggcca cgtgcattgc catgctcgcc atgcttggaa acaggagtgc
aaggaccaga 6720ctgagcagcg tcctctgtgt gagcagtaca cccatggtga
actctgagtt gtctagagca 6780aacagcagaa cagtgaaaat gtaaggatgg
aatgctgtac atagtaccat gcagggtact 6840ctatggtagg ctacaacagt
aaattacgag cagtttttag gcaattaaat gttaacaagt 6900agttttaaag
taattctgtg gtaatgtgtc tgttgctata tccacctctc atgtgcatgt
6960tcaaaaccat attcataaat ctatttatgt atttgcattc agttgtcttt
tgggtagcaa 7020actgtcccag aagccagttg cctctacata tttttgttca
gtgaaagcta gaattcattg 7080atacttttca gtacctctga ttaaaacaca
atctgatagg cttgcaaaac tggaaattca 7140aagagcaaat ttcagtaaac
tttaggtttg gacagatata tgagaaagca gaggcttgct 7200gactatttta
tttcttattt ttattcccta aaaataaatg tagagaaata tctgtttgtt
7260gcacactact tgctatgagt agatcttcaa aagtattttt acctttgttt
tggtgatggc 7320agaatagata aggaatgtaa tttatatggg gtcatgtagt
ctaggagaaa gacacgcatg 7380taattcatat tctgctctat tgcactttca
ggtatggttt gctttgctca aagatatgca 7440tgtgtactgt agtataaact
ttctgtggag ttaaatttta gtggtgacat tcagacagaa 7500gagaaatgca
gacatgataa aatagcaatg tttactataa aacagagcca ctgaatgaat
7560tcttgttcat gacatagacc aatagaagat ttatacttgt tctgtctgtt
tctattataa 7620agagctgaac tgtacaacta ttgtatagcc agtgtgctta
tataaagcac agcttttgga 7680gccagcatga atctagttgc tttcctgaga
tttatataat ctgtgaaagt cagaagtcct 7740tcagagccca gccctttata
tgcgtactga gtgctggggc ctcaggattg gattttctgt 7800attaaacccc
tcaaaagttt ttactgacca cgtgtgtgag tatacacaca cacatttttc
7860tcattttctt ttctgtatat aagttcacat gtatctatta ttgtaagaat
atacgtttat 7920gcacccccca catttttatc ttgtgtagtg atcagcagct
gcactttgca ggaattaaac 7980ttctagagaa ttttcacatt aaaataactc
cccagaattc actgaacacc atgattttgc 8040tctctgtgca ctctgtaggg
ctagaagtta atcaagcaaa ctgcaaagca tatcagatag 8100tgaacgacag
gataagatgt tctgaaatta aaaacatatt ttaagcacaa agaataagcc
8160tcctgaaaac aaacacaaag cttttacaca taataaaata gtgcagaatg
catacacagg 8220tgagaagttt ttataggggg tatcacgcag gtacttcacc
cttaaagata caacacatag 8280cacaataatt gttaattttt taaagtttag
gtgcaagtaa gagctaatat agagagaagg 8340taattccaga gagttgctta
cctttcgagc ttgactgcta aaggcaatac agctttctag 8400ctgtatgtac
agacactggc tgagccctgg ggaatatata gtctgaattg tgacccaccc
8460acaggttccc ttcagaagtt tgacctttga caccatagaa atcatttaat
gggattgggt 8520tagattttag tttcaatagg tccattttgg attgaatgga
gagcaaatat tagtttttaa 8580ttctgggtaa caatgtgttt tctgcctgtt
ctgctaatcc atcaggactg ttggatggga 8640gagaagactg ggaaatattg
ctcatgttcc attgagcttc agttacaacc agataatggg 8700atctttaaga
aaacagaaaa atgtgggaac cttggagatg gaaaacataa ttagcaatta
8760ttagttagtg tgcttattac tatggttgta gtaacagacc agaagtctgt
ttcatttgat 8820ccttcttgta tgtacaatgt gcatctgagc cacgctagac
aggacataaa tgagaacaag 8880acttgaccta ttattttctt gacaaaatag
gagaaataaa gaagcgtgca tgtgaaggag 8940ccaactgaga ctagagtgaa
gagcagacac actttctttc ctatagttgg aatatttaaa 9000tctatctttt
tatgggtgtg aatgctttat aacaaacttt tattctgagg atacagcaaa
9060acatagctcc atacaatgca aaacaatact caatttcaaa tgtgtttatg
atatgaactt 9120gcagtgttcc tcaaagatct tccatgaata acttaatggc
ctggcagatg acagaggaat 9180tgtgaaattc agctggagga gtgttcatgg
ttcgagggac aatcataata tacaatagca 9240aatatatttc agttatagaa
gctattgttc tgtattgaaa taatagaatt gacaaacagt 9300aaagaaacca
ttctgacctc tgtaaagcac tgtttgattt aaaaatgggg gaaaaaagta
9360caacataatt cttcaggaca tacatagaga tcactgcaat ctctgttaag
cagaattact 9420ttcctatacc actagctgaa gtttagtcag tgccattttc
ttttgtttct ctccttcctt 9480ttgtgaaaac atatatactg tggaaatcta
cattctcctt gccaagtctg aggacttaag 9540acaagatggt agtgcaaata
atattttttt gctggatgtc tacaccacag gtatcaactg 9600attttttttg
tttcattttg tttttaatca cgtcttttgc ttctatttca gccactaaga
9660aagtctgaaa atcttgcctg ctttttgtga tgatagatgt gcttcccagt
aaatgttatc 9720tctacctatg aaatgcatgt cagtctgcag aaagagaaag
gagattggga ataggttttc 9780tcagatgcac ttctctgtca tctggtgtca
atcaaacact aataatttgt gtatagatat 9840cttatatata tatatatatt
tggaatttgc aggttggcat agttcagata gtcctgtcac 9900attgtaatat
cctggtgaga taacaaggaa aagagagacc gtttcggctc ttactaaggc
9960agggaactgc ttaccagaca gggaggttct ggagatgaca tccagcatga
aaagcacact 10020tccaaatact taaaggtatc aagtctaact tgtcagacag
gctccagaat aacttctgtc 10080ctaatgctac agaaaagggg gaaggtatcc
accatggcca aaattgtcag ccattttgtc 10140tcagcaaaca gcagatctgg
tcagtaagga caagattctt ccaaagcaac catgccatat 10200ataattaagc
atgtgtaatt aattaataaa aaatataatt tagtgtattt cctcctttgg
10260atgttatgaa gaaatgcttt tattaacaat tcaccataat ctgtcctaag
agtagtgaat 10320aacaacaggc tgcttctcac cctgtggttg ggtgtaccag
tgagccagag ctaaacgcca 10380cgtttcctct tttgtatccc atagcagaga
gggtctccat ttcatttctg tagctcagaa 10440agttgtagtg gatttacact
acaagttgtg gtagtggagg tctgccggag tggcctctgt 10500gaacagagcc
cagcagctgt cccgtgtcct caaaagggag ctgccactgg ccagagctga
10560gccagtgatc gatgctagat gtacctcagg aggagcaata tgtaagaaca
actgctgtac 10620aatggtagtt gggagaggtg agtgagaaaa tgtgagagaa
acagccctga tgacactgag 10680gtcagtgcgg aggagggcag gaggtgttcc
aggtgtagaa cagaagttcc ctgcagccca 10740agagaggccc atggtggagc
actctgaccc tctgcagccc atggtatatc atataaacct 10800cagttctgtg
acattatttt aactccatat cccttttctg ttcagggtca ctttgagttc
10860acagccattt ctttatattt ctccaatatc agccttccat tgctacatat
gagacttgga 10920cagtacatct gattcagtca aatctgcctt cagaacgtcc
ctgaagccct tcttagacag 10980tctcaattct ccttcccttc atctctttta
tcatacatgg accacggacc tgtccagacc 11040tgagtcatat gtccatcttt
acgtccatct ctatgtcttg tactttaaga caaataaaat 11100atcaaggaaa
ttgatgcagt tatgtcagtt atcactgtca tagtatcgtg ctgcaaatat
11160aagatgagaa tgatcccaaa ggctttttaa agctgctcta tttgacttcc
acatagtgtc 11220ctgattccag acctacagaa cagttttgta tgcatttgac
ttgcagagct ttgttttgtg 11280agtcttataa aagccatttt tcctctccaa
gaagtagccg gtggtttaaa acaatgtaga 11340ttaagtgtgg agcatgagaa
tttctgcttt tctgtcagat gagaaggata tactacactc 11400tttcccaatg
gaagaccagc tgcaagcaac aaaaattgtc catgaacaaa tgagatcttg
11460atcagaacag gctgtcatca tagtgttgtc agcatacctg catagttggt
ttgacttggg 11520ggtctagaga gagtaagcaa caatcttctt gcagttggaa
ggttacctgg gataggtggc 11580aatggattgc cctgcccagc acagctgtgc
aaagcagtac aaatagtttt gtcacacatt 11640gtttgacaat gcttgtccca
agaaaaggtc agctaaggct ctgctgccct ttcctatgcc 11700aggcatttca
ttgtgggtct gtccctaaac caacagtctc atgaataaag actcggagac
11760ctgaaagtta taaaagcact ttttatccaa aaggatatga agtccaggtg
agctcacagg 11820tcaaagcctc ttatccaatc actaaaacct actcagaact
tgactcga 118682010021DNAArtificial SequencepSIN-3.9-OM-CTLA4-Fc
Vector 20ctagactagg atcccccgtg ctgcagaacc gagcggctat tgacttcttg
ctcctagctc 60acggccatgg ctgtgaggac attgcgggaa tgtgttgttt caatctgagt
gatcacagtg 120agtctataca gaagaagttc cagctaatga aggaacatgt
caataagatc ggcgtgaaca 180acgacccaat cggaagttgg ctgcgaggat
tattcggagg aataggagaa tgggccgtac 240acttgctgaa aggactgctt
ttggggcttg tagttatctt gttgctagta gtatgcttgc 300cttgcctttt
gcaatgtgta tctagtagta ttcgaaagat gattgataat tcactcggct
360atcgcgagga atataaaaaa attacaggag gcttataagc agcccgaaag
aagagcgtag 420gcgagttctt gtattccgtg tgatagctgg ttggattggt
aattgatcgg ctggcacgcg 480gaatatagga ggtcgctgaa tagtaaactt
gtagacttgg ctacagcata gagtatcttc 540tgtagctctg atgactgcta
ggaaataatg ctacggataa tgtggggagg gcaaggcttg 600cgaatcgggt
tgtaacgggc aaggcttgac tgaggggaca atagcatgtt taggcgaaaa
660gcggggcttc ggttgtacgc ggttaggagt cccctcagga tatagtagtt
tcgcttttgc 720atagggaggg ggacggattg gacgaaccac tgaattccgc
attgcagaga tattgtattt 780aagtgcctag ctcgatacaa taaacgccat
ttgaccattc accacattgg tgtgcacctg 840ggttgatggc cggaccgttg
attccctgrc gactacgagc acatgcatga agcagaaggc 900ttcatttggt
gaccccgacg tgatcgttag ggaatacgcg ctcactggcc gtcgttttac
960aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca
gcacatcccc 1020ctttcgccag ctggcgtaat agcgaagagg cccgcaccga
tcgcccttcc caacagttgc 1080gcagcctgaa tggcgaatgg aaattgtaag
cgttaatatt ttgttaaaat tcgcgttaaa 1140tttttgttaa atcagctcat
tttttaacca ataggccgaa atcggcaaaa tcccttataa 1200atcaaaagaa
tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact
1260attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg
gcgatggccc 1320actacgtgaa ccatcaccct aatcaagttt tttggggtcg
aggtgccgta aagcactaaa 1380tcggaaccct aaagggagcc cccgatttag
agcttgacgg ggaaagccgg cgaacgtggc 1440gagaaaggaa gggaagaaag
cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt 1500cacgctgcgc
gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcagg
1560tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct
aaatacattc 1620aaatatgtat ccgctcatga gacaataacc ctgataaatg
cttcaataat attgaaaaag 1680gaagagtatg agtattcaac atttccgtgt
cgcccttatt cccttttttg cggcattttg 1740ccttcctgtt tttgctcacc
cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 1800gggtgcacga
gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt
1860tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat
gtggcgcggt 1920attatcccgt attgacgccg ggcaagagca actcggtcgc
cgcatacact attctcagaa 1980tgacttggtt gagtactcac cagtcacaga
aaagcatctt acggatggca tgacagtaag 2040agaattatgc agtgctgcca
taaccatgag tgataacact gcggccaact tacttctgac 2100aacgatcgga
ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac
2160tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg
agcgtgacac 2220cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta
ttaactggcg aactacttac 2280tctagcttcc cggcaacaat taatagactg
gatggaggcg gataaagttg caggaccact 2340tctgcgctcg gcccttccgg
ctggctggtt tattgctgat aaatctggag ccggtgagcg 2400tgggtctcgc
ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt
2460tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga
tcgctgagat 2520aggtgcctca ctgattaagc attggtaact gtcagaccaa
gtttactcat atatacttta 2580gattgattta aaacttcatt tttaatttaa
aaggatctag gtgaagatcc tttttgataa 2640tctcatgacc aaaatccctt
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga 2700aaagatcaaa
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac
2760aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac
caactctttt 2820tccgaaggta actggcttca gcagagcgca gataccaaat
actgtccttc tagtgtagcc 2880gtagttaggc caccacttca agaactctgt
agcaccgcct acatacctcg ctctgctaat 2940cctgttacca gtggctgctg
ccagtggcga taagtcgtgt cttaccgggt tggactcaag 3000acgatagtta
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc
3060cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc
tatgagaaag 3120cgccacgctt cccgaaggga gaaaggcgga caggtatccg
gtaagcggca gggtcggaac 3180aggagagcgc acgagggagc ttccaggggg
aaacgcctgg tatctttata gtcctgtcgg 3240gtttcgccac ctctgacttg
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct 3300atggaaaaac
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc
3360tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta
ccgcctttga 3420gtgagctgat accgctcgcc gcagccgaac gaccgagcgc
agcgagtcag tgagcgagga 3480agcggaagag cgcccaatac gcaaaccgcc
tctccccgcg cgttggccga ttcattaatg 3540cagctggcac gacaggtttc
ccgactggaa agcgggcagt gagcgcaacg caattaatgt 3600gagttagctc
actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt
3660gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc
atgattacgc 3720caagcgcgca ttggtaattg atcggctggc acgcggaata
taggaggtcg ctgaatagta 3780aacttgtaga cttggctaca gcatagagta
tcttctgtag ctctgatgac tgctaggaaa 3840taatgctacg gataatgtgg
ggagggcaag gcttgcgaat cgggttgtaa cgggcaaggc 3900ttgactgagg
ggacaatagc atgtttaggc gaaaagcggg gcttcggttg tacgcggtta
3960ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa
tgtagtctta 4020tgcaatactc ttgtagtctt gcaacatgct tatgtaacga
tgagttagca acatgcctta 4080taaggagaga aaaagcaccg tgcatgccga
ttggtgggag taaggtggta tgatcgtggt 4140atgatcgtgc cttgttagga
aggcaacaga cgggtctaac acggattgga cgaaccactg 4200aattccgcat
tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgccattt
4260gaccattcac cacattggtg tgcacctggg ttgatggccg gaccgttgat
tccctgrcga 4320ctacgagcac atgcatgaag cagaaggctt catttggtga
ccccgacgtg atcgttaggg 4380aatagtggtc ggccacaggc ggcgtggcga
tcctgtcctc atccgtctcg cttattcggg 4440gagcggacga tgaccctagt
agagggggct gcggcttagg agggcagaag ctgagtggcg 4500tcggagggag
ccctactgca gggggccaac ataccctacc gagaactcag agagtcgttg
4560gaagacggga aggaagcccg acgactgagc ggtccacccc aggcgtgatt
ccggttgctc 4620tgcgtgattc cggtcgcccg gtggatcaag catggaagcc
gtcataaagg tgatttcgtc 4680cgcgtgtaag acctattgcg ggaaaacctc
tccttctaag aaggaaatag gggctatgtt 4740gtccctgtta caaaaggaag
ggttgcttac gtccccctca gacttatatt ccccggggtc 4800ctgggatccc
attaccgcgg cgctctctca gcgggctatg gtacttggaa aatcgggaga
4860gttaaaaacc tggggattgg ttttgggggc attgaaggcg gctcgaggtc
gacggtatcg 4920ataagcttgc agtccaaggc tttgtctgtg tacccagtga
aatccttcct ctgttacata 4980aagcccagat aggactcaga aatgtagtca
ttccagcccc cctcttcctc agatctggag 5040cagcacttgt ttgcagccag
tcctccccaa aatgcacaga cctcgccgag tggagggaga 5100tgtaaacagc
gaaggttaat tacctccttg tcaaaaacac tttgtggtcc atagatgttt
5160ctgtcaatct tacaaaacag aaccgagagg cagcgagcac tgaagagcgt
gttcccatgc 5220tgagttaatg agacttggca gctcgctgtg cagagatgat
ccctgtgctt catgggaggc 5280tgtaacctgt ctccccatcg ccttcacacc
gcagtgctgt cctggacacc tcaccctcca 5340taagctgtag gatgcagctg
cccagggatc aagagacttt tcctaaggct cttaggactc 5400atctttgccg
ctcagtagcg tgcagcaatt actcatccca actatactga atgggtttct
5460gccagctctg cttgtttgtc aataagcatt tcttcatttt gcctctaagt
ttctctcagc 5520agcaccgctc tgggtgacct gagtggccac ctggaacccg
aggggcacag ccaccacctc 5580cctgttgctg ctgctccagg gactcatgtg
ctgctggatg gggggaagca tgaagttcct 5640cacccagaca cctgggttgc
aatggctgca gcgtgctctt cttggtatgc agattgtttc 5700cagccattac
ttgtagaaat gtgctgtgga agccctttgt atctctttct gtggcccttc
5760agcaaaagct gtgggaaagc tctgaggctg ctttcttggg tcgtggagga
attgtatgtt 5820ccttctttaa caaaaattat ccttaggaga gagcactgtg
caagcattgt gcacataaaa 5880caattcaggt tgaaagggct ctctggaggt
ttccagcctg actactgctc gaagcaaggc 5940caggttcaaa gatggctcag
gatgctgtgt gccttcctga ttatctgtgc caccaatgga 6000ggagattcac
agccactctg cttcccgtgc cactcatgga gaggaatatt cccttatatt
6060cagatagaat gttatccttt agctcagcct tccctataac cccatgaggg
agctgcagat 6120ccccatactc tccccttctc tggggtgaag gccgtgtccc
ccagcccccc ttcccaccct 6180gtgccctaag cagcccgctg gcctctgctg
gatgtgtgcc tatatgtcaa tgcctgtcct 6240tgcagtccag cctgggacat
ttaattcatc accagggtaa tgtggaactg tgtcatcttc 6300ccctgcaggg
tacaaagttc tgcacggggt cctttcggtt caggaaaacc ttcactggtg
6360ctacctgaat caagctctat ttaataagtt cataagcaca tggatgtgtt
ttcctagaga 6420tacgttttaa tggtatcagt gatttttatt tgctttgttg
cttacttcaa acagtgcctt 6480tgggcaggag gtgagggacg ggtctgccgt
tggctctgca gtgatttctc caggcgtgtg 6540gctcaggtca gatagtggtc
actctgtggc cagaagaagg acaaagatgg aaattgcaga 6600ttgagtcacg
ttaagcaggc atcttggagt gatttgaggc agtttcatga aagagctacg
6660accacttatt gttgttttcc ccttttacaa cagaagtttt catcaaaata
acgtggcaaa 6720gcccaggaat gtttgggaaa agtgtagtta aatgttttgt
aattcatttg tcggagtgct 6780accagctaag aaaaaagtcc tacctttggt
atggtagtcc tgcagagaat acaacatcaa 6840tattagtttg gaaaaaaaca
ccaccaccac cagaaactgt aatggaaaat gtaaaccaag 6900aaattccttg
ggtaagagag aaaggatgtc gtatactggc caagtcctgc ccagctgtca
6960gcctgctgac cctctgcagt tcaggaccat gaaacgtggc actgtaagac
gtgtcccctg 7020cctttgcttg cccacagatc tctgcccttg tgctgactcc
tgcacacaag agcatttccc 7080tgtagccaaa cagcgattag ccataagctg
cacctgactt tgaggattaa gagtttgcaa 7140ttaagtggat tgcagcagga
gatcagtggc agggttgcag atgaaatcct tttctagggg 7200tagctaaggg
ctgagcaacc tgtcctacag cacaagccaa accagccaag ggttttcctg
7260tgctgttcac agaggcaggg ccagctggag ctggaggagg ttgtgctggg
acccttctcc 7320ctgtgctgag aatggagtga tttctgggtg ctgttcctgt
ggcttgcact gagcagctca 7380agggagatcg gtgctcctca tgcagtgcca
aaactcgtgt ttgatgcaga aagatggatg 7440tgcacctccc tcctgctaat
gcagccgtga gcttatgaag gcaatgagcc ctcagtgcag 7500caggagctgt
agtgcactcc tgtaggtgct agggaaaatc tctggttccc agggatgcat
7560tcataagggc aatatatctt gaggctgcgc caaatctttc tgaaatattc
atgcgtgttc 7620ccttaattta tagaaacaaa cacagcagaa taattattcc
aatgcctccc ctcgaaggaa 7680acccatattt ccatgtagaa atgtaaccta
tatacacaca gccatgctgc atccttcaga 7740acgtgccagt gctcatctcc
catggcaaaa tactacaggt attctcacta tgttggacct 7800gtgaaaggaa
ccatggtaag aaacttcggt taaaggtatg gctgcaaaac tactcatacc
7860aaaacagcag agctccagac ctcctcttag gaaagagcca cttggagagg
gatggtgtga 7920aggctggagg tgagagacag agcctgtccc agttttcctg
tctctatttt ctgaaacgtt 7980tgcaggagga aaggacaact gtactttcag
gcatagctgg tgccctcacg taaataagtt 8040ccccgaactt ctgtgtcatt
tgttcttaag atgctttggc agaacacttt gagtcaattc 8100gcttaactgt
gactaggtct gtaaataagt gctccctgct gataaggttc aagtgacatt
8160tttagtggta tttgacagca tttaccttgc tttcaagtct tctaccaagc
tcttctatac 8220ttaagcagtg aaaccgccaa gaaacccttc cttttatcaa
gctagtgcta aataccatta 8280acttcatagg ttagatacgg tgctgccagc
ttcacctggc agtggttggt cagttctgct 8340ggtgacaaag cctccctggc
ctgtgctttt acctagaggt gaatatccaa gaatgcagaa 8400ctgcatggaa
agcagagctg caggcacgat ggtgctgagc cttagctgct tcctgctggg
8460agatgtggat gcagagacga atgaaggacc tgtcccttac tcccctcagc
attctgtgct 8520atttagggtt ctaccagagt ccttaagagg tttttttttt
ttttggtcca aaagtctgtt 8580tgtttggttt tgaccactga gagcatgtga
cacttgtctc aagctattaa ccaagtgtcc 8640agccaaaatc aattgcctgg
gagacgcaga ccattacctg gaggtcagga cctcaataaa 8700tattaccagc
ctcattgtgc cgctgacaga ttcagctggc tgctccgtgt tccagtccaa
8760cagttcggac gccacgtttg tatatatttg caggcagcct cggggggacc
atctcaggag 8820cagagcaccg gcagccgcct gcagagccgg gcagtacctc
aacatgggtg tactgctcac 8880acagaggacg ctgctcagtc tggtccttgc
actcctgttt ccaagcatgg cgagcatggc 8940aatgcacgtg gcccagcctg
ctgtggtact ggccagcagc cgaggcatcg cyagctttgt 9000gtgtgagtat
gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc
9060tgacagccag gtgactgaag tctgtgcggc aacctacatg atggggaatg
agttgacctt 9120cctagatgat tccatctgca cgggcacctc cagtggaaat
caagtgaacc tcactatcca 9180aggactgagg gccatggaca cgggactcta
catctgcaag gtggagctca tgtacccacc 9240gccatactac ctgggcatag
gcaacggaac ccagatttat gtaattgatc cagaaccgtg 9300cccagattct
gatcaggagc ccaaatcttc tgacaaaact cacacatccc caccgtcccc
9360agcacctgaa ctcctggggg gatcgtcagt cttcctcttc cccccaaaac
ccaaggacac 9420cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg
gtggacgtga gccacgaaga 9480ccctgaggtc aagttcaact ggtacgtgga
cggcgtggag gtgcataatg ccaagacaaa 9540gccgcgggag gagcagtaca
acagcacgta ccgggtggtc agcgtcctca ccgtcctgca 9600ccaggactgg
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc
9660ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac
aggtgtacac 9720cctgccccca tcccgggatg agctgaccaa gaaccaggtc
agcctgacct gcctggtcaa
9780aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc
cggagaacaa 9840ctacaagacc acgcctcccg tgctggactc cgacggctcc
ttcttcctct acagcaagct 9900caccgtggac aagagcaggt ggcagcaggg
gaacgtcttc tcatgctccg tgatgcatga 9960ggctctgcac aaccactaca
cgcagaagag cctctccctg tctccgggta aatgaggaat 10020t
10021217350DNAArtificial SequencepSIN-1.8-OM-IFNa-2B Vector
21tcgagatcaa ttgctagact aggatccccc gtgctgcaga accgagcggc tattgacttc
60ttgctcctag ctcacggcca tggctgtgag gacattgcgg gaatgtgttg tttcaatctg
120agtgatcaca gtgagtctat acagaagaag ttccagctaa tgaaggaaca
tgtcaataag 180atcggcgtga acaacgaccc aatcggaagt tggctgcgag
gattattcgg aggaatagga 240gaatgggccg tacacttgct gaaaggactg
cttttggggc ttgtagttat cttgttgcta 300gtagtatgct tgccttgcct
tttgcaatgt gtatctagta gtattcgaaa gatgattgat 360aattcactcg
gctatcgcga ggaatataaa aaaattacag gaggcttata agcagcccga
420aagaagagcg taggcgagtt cttgtattcc gtgtgatagc tggttggatt
ggtaattgat 480cggctggcac gcggaatata ggaggtcgct gaatagtaaa
cttgtagact tggctacagc 540atagagtatc ttctgtagct ctgatgactg
ctaggaaata atgctacgga taatgtgggg 600agggcaaggc ttgcgaatcg
ggttgtaacg ggcaaggctt gactgagggg acaatagcat 660gtttaggcga
aaagcggggc ttcggttgta cgcggttagg agtcccctca ggatatagta
720gtttcgcttt tgcataggga gggggacgga ttggacgaac cactgaattc
cgcattgcag 780agatattgta tttaagtgcc tagctcgata caataaacgc
catttgacca ttcaccacat 840tggtgtgcac ctgggttgat ggccggaccg
ttgattccct grcgactacg agcacatgca 900tgaagcagaa ggcttcattt
ggtgaccccg acgtgatcgt tagggaatac gcgctcactg 960gccgtcgttt
tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt
1020gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac
cgatcgccct 1080tcccaacagt tgcgcagcct gaatggcgaa tggaaattgt
aagcgttaat attttgttaa 1140aattcgcgtt aaatttttgt taaatcagct
cattttttaa ccaataggcc gaaatcggca 1200aaatccctta taaatcaaaa
gaatagaccg agatagggtt gagtgttgtt ccagtttgga 1260acaagagtcc
actattaaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc
1320agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg
tcgaggtgcc 1380gtaaagcact aaatcggaac cctaaaggga gcccccgatt
tagagcttga cggggaaagc 1440cggcgaacgt ggcgagaaag gaagggaaga
aagcgaaagg agcgggcgct agggcgctgg 1500caagtgtagc ggtcacgctg
cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac 1560agggcgcgtc
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt
1620tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa
atgcttcaat 1680aatattgaaa aaggaagagt atgagtattc aacatttccg
tgtcgccctt attccctttt 1740ttgcggcatt ttgccttcct gtttttgctc
acccagaaac gctggtgaaa gtaaaagatg 1800ctgaagatca gttgggtgca
cgagtgggtt acatcgaact ggatctcaac agcggtaaga 1860tccttgagag
ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc
1920tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt
cgccgcatac 1980actattctca gaatgacttg gttgagtact caccagtcac
agaaaagcat cttacggatg 2040gcatgacagt aagagaatta tgcagtgctg
ccataaccat gagtgataac actgcggcca 2100acttacttct gacaacgatc
ggaggaccga aggagctaac cgcttttttg cacaacatgg 2160gggatcatgt
aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg
2220acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa
ctattaactg 2280gcgaactact tactctagct tcccggcaac aattaataga
ctggatggag gcggataaag 2340ttgcaggacc acttctgcgc tcggcccttc
cggctggctg gtttattgct gataaatctg 2400gagccggtga gcgtgggtct
cgcggtatca ttgcagcact ggggccagat ggtaagccct 2460cccgtatcgt
agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac
2520agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac
caagtttact 2580catatatact ttagattgat ttaaaacttc atttttaatt
taaaaggatc taggtgaaga 2640tcctttttga taatctcatg accaaaatcc
cttaacgtga gttttcgttc cactgagcgt 2700cagaccccgt agaaaagatc
aaaggatctt cttgagatcc tttttttctg cgcgtaatct 2760gctgcttgca
aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc
2820taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca
aatactgtcc 2880ttctagtgta gccgtagtta ggccaccact tcaagaactc
tgtagcaccg cctacatacc 2940tcgctctgct aatcctgtta ccagtggctg
ctgccagtgg cgataagtcg tgtcttaccg 3000ggttggactc aagacgatag
ttaccggata aggcgcagcg gtcgggctga acggggggtt 3060cgtgcacaca
gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg
3120agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat
ccggtaagcg 3180gcagggtcgg aacaggagag cgcacgaggg agcttccagg
gggaaacgcc tggtatcttt 3240atagtcctgt cgggtttcgc cacctctgac
ttgagcgtcg atttttgtga tgctcgtcag 3300gggggcggag cctatggaaa
aacgccagca acgcggcctt tttacggttc ctggcctttt 3360gctggccttt
tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta
3420ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag
cgcagcgagt 3480cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc
gcctctcccc gcgcgttggc 3540cgattcatta atgcagctgg cacgacaggt
ttcccgactg gaaagcgggc agtgagcgca 3600acgcaattaa tgtgagttag
ctcactcatt aggcacccca ggctttacac tttatgcttc 3660cggctcgtat
gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg
3720accatgatta cgccaagcgc gcattggtaa ttgatcggct ggcacgcgga
atataggagg 3780tcgctgaata gtaaacttgt agacttggct acagcataga
gtatcttctg tagctctgat 3840gactgctagg aaataatgct acggataatg
tggggagggc aaggcttgcg aatcgggttg 3900taacgggcaa ggcttgactg
aggggacaat agcatgttta ggcgaaaagc ggggcttcgg 3960ttgtacgcgg
ttaggagtcc cctcaggata tagtagtttc gcttttgcat agggaggggg
4020aaatgtagtc ttatgcaata ctcttgtagt cttgcaacat gcttatgtaa
cgatgagtta 4080gcaacatgcc ttataaggag agaaaaagca ccgtgcatgc
cgattggtgg gagtaaggtg 4140gtatgatcgt ggtatgatcg tgccttgtta
ggaaggcaac agacgggtct aacacggatt 4200ggacgaacca ctgaattccg
cattgcagag atattgtatt taagtgccta gctcgataca 4260ataaacgcca
tttgaccatt caccacattg gtgtgcacct gggttgatgg ccggaccgtt
4320gattccctgr cgactacgag cacatgcatg aagcagaagg cttcatttgg
tgaccccgac 4380gtgatcgtta gggaatagtg gtcggccaca ggcggcgtgg
cgatcctgtc ctcatccgtc 4440tcgcttattc ggggagcgga cgatgaccct
agtagagggg gctgcggctt aggagggcag 4500aagctgagtg gcgtcggagg
gagccctact gcagggggcc aacataccct accgagaact 4560cagagagtcg
ttggaagacg ggaaggaagc ccgacgactg agcggtccac cccaggcgtg
4620attccggttg ctctgcgtga ttccggtcgc ccggtggatc aagcatggaa
gccgtcataa 4680aggtgatttc gtccgcgtgt aagacctatt gcgggaaaac
ctctccttct aagaaggaaa 4740taggggctat gttgtccctg ttacaaaagg
aagggttgct tacgtccccc tcagacttat 4800attccccggg gtcctgggat
cccattaccg cggcgctctc tcagcgggct atggtacttg 4860gaaaatcggg
agagttaaaa acctggggat tggttttggg ggcattgaag gcggctcgac
4920ggatccgtta accctagaac tagtggatct ctgcccttgt gctgactcct
gcacacaaga 4980gcatttccct gtagccaaac agcgattagc cataagctgc
acctgacttt gaggattaag 5040agtttgcaat taagtggatt gcagcaggag
atcagtggca gggttgcaga tgaaatcctt 5100ttctaggggt agctaagggc
tgagcaacct gtcctacagc acaagccaaa ccagccaagg 5160gttttcctgt
gctgttcaca gaggcagggc cagctggagc tggaggaggt tgtgctggga
5220cccttctccc tgtgctgaga atggagtgat ttctgggtgc tgttcctgtg
gcttgcactg 5280agcagctcaa gggagatcgg tgctcctcat gcagtgccaa
aactcgtgtt tgatgcagaa 5340agatggatgt gcacctccct cctgctaatg
cagccgtgag cttatgaagg caatgagccc 5400tcagtgcagc aggagctgta
gtgcactcct gtaggtgcta gggaaaatct ctggttccca 5460gggatgcatt
cataagggca atatatcttg aggctgcgcc aaatctttct gaaatattca
5520tgcgtgttcc cttaatttat agaaacaaac acagcagaat aattattcca
atgcctcccc 5580tcgaaggaaa cccatatttc catgtagaaa tgtaacctat
atacacacag ccatgctgca 5640tccttcagaa cgtgccagtg ctcatctccc
atggcaaaat actacaggta ttctcactat 5700gttggacctg tgaaaggaac
catggtaaga aacttcggtt aaaggtatgg ctgcaaaact 5760actcatacca
aaacagcaga gctccagacc tcctcttagg aaagagccac ttggagaggg
5820atggtgtgaa ggctggaggt gagagacaga gcctgtccca gttttcctgt
ctctattttc 5880tgaaacgttt gcaggaggaa aggacaactg tactttcagg
catagctggt gccctcacgt 5940aaataagttc cccgaacttc tgtgtcattt
gttcttaaga tgctttggca gaacactttg 6000agtcaattcg cttaactgtg
actaggtctg taaataagtg ctccctgctg ataaggttca 6060agtgacattt
ttagtggtat ttgacagcat ttaccttgct ttcaagtctt ctaccaagct
6120cttctatact taagcagtga aaccgccaag aaacccttcc ttttatcaag
ctagtgctaa 6180ataccattaa cttcataggt tagatacggt gctgccagct
tcacctggca gtggttggtc 6240agttctgctg gtgacaaagc ctccctggcc
tgtgctttta cctagaggtg aatatccaag 6300aatgcagaac tgcatggaaa
gcagagctgc aggcacgatg gtgctgagcc ttagctgctt 6360cctgctggga
gatgtggatg cagagacgaa tgaaggacct gtcccttact cccctcagca
6420ttctgtgcta tttagggttc taccagagtc cttaagaggt tttttttttt
tttggtccaa 6480aagtctgttt gtttggtttt gaccactgag agcatgtgac
acttgtctca agctattaac 6540caagtgtcca gccaaaatca attgcctggg
agacgcagac cattacctgg aggtcaggac 6600ctcaataaat attaccagcc
tcattgtgcc gctgacagat tcagctggct gctccgtgtt 6660ccagtccaac
agttcggacg ccacgtttgt atatatttgc aggcagcctc ggggggacca
6720tctcaggagc agagcaccgg cagccgcctg cagagccggg cagtacctca
ccatggcttt 6780gacctttgcc ttactggtgg ctctcctggt gctgagctgc
aagagcagct gctctgtggg 6840ctgcgatctg cctcagaccc acagcctggg
cagcaggagg accctgatgc tgctggctca 6900gatgaggaga atcagcctgt
ttagctgcct gaaggatagg cacgattttg gctttcctca 6960agaggagttt
ggcaaccagt ttcagaaggc tgagaccatc cctgtgctgc acgagatgat
7020ccagcagatc tttaacctgt ttagcaccaa ggatagcagc gctgcttggg
atgagaccct 7080gctggataag ttttacaccg agctgtacca gcagctgaac
gatctggagg cttgcgtgat 7140ccagggcgtg ggcgtgaccg agacccctct
gatgaaggag gatagcatcc tggctgtgag 7200gaagtacttt cagaggatca
ccctgtacct gaaggagaag aagtacagcc cctgcgcttg 7260ggaagtcgtg
agggctgaga tcatgaggag ctttagcctg agcaccaacc tgcaagagag
7320cttgaggtct aaggagtaaa aagtctaggc 73502216051DNAArtificial
Sequence16 kbp Ovalbumin Sequence 22ctgcagccca ggcagcacac
tagagcagag aaatctagtt agcagcaacc actggcagac 60agaaatgatt atatagatta
catactgacc ctagcctctt acactgccta ctgcatcact 120gaaaggactg
ggaagaagag agtgcaataa cgaagctgaa gctaggagga aggcaaggag
180aactgaagct gactagggaa aagggggatt aaaggtttaa gtgtctattc
catagtttgc 240tggtttgttt tttgtcaatt cctgaatcag taatttttat
gttaattagc aaaaaattac 300aaacactccc caagtcagga ctgttaccta
caacagaagc tcagatcagc tgagccttag 360tcttttggtc cctccctagg
gaatgctgta tgtgtctctc tctccaggcc tgctcaaaat 420tgacctcaga
cccaaacttt tgctgaatct ccagtaccac ctcttttgct cctaactaga
480taacaaagcc ctgagcgctt tgcttttagc aaagctttaa gtgccattac
caactgcacc 540tggagccttt acctacccct atggacccag gctctatatt
taagctctgc cctgaacctt 600cacttctttc ctgtcctaag ttagatgtac
tagtatggtg tgtactatgt ctccagttca 660aacacagctg tgcccatacc
tggccaagga ctcctagtat gacctgggct gtgccttgct 720gctaaggacc
tgctgggtga ttgctggacc tgatcctaat cctgaattaa gaaatgattt
780cttggcttga ctggatgtgc cctgtggtat gatactgcct tatgatttgg
actcttgttt 840gcagctgtgc aaatccctaa ggagcccagt ctctggccac
ctggaatctt gtcactacca 900aacttcctga gggactggtc ttgctctggg
ttctgatctc tggacagtac tcacccttta 960ctcagcccag gctcccagtt
aagccccttt ccaccctgcc aggctctccg ctccatccct 1020agcaggggct
ctcatgacag tgtgaccccc ccttactcag gtcagggcca cttgtgccac
1080gttcctttcc tgtcttctgt ccctgccttg gctctaaagc agtgtgctac
catccacaac 1140cactgcatct ctctaaagta agcctctcct gagcccaagt
ctctgtaacg aggaaggatg 1200cactttgctc agaaggatgc gaggctgctt
ctgagctctg agggcactga cctcccatga 1260ggtacacccc atacccagga
ccacaattca gcctgctgga accatcaact cctgctggag 1320taaggccata
gcaagaccag catccacctc cctgcagccc tgccctgccc agatattggg
1380cctgctgatc tcaggatgca gacttgcttc tcagcttgac ctaagcattg
ccctgtcttt 1440atggacccac ctggttagca agttcagtgc agaaggaggc
tgttggcatc tagctaattt 1500tccacccaca ttactgtctg ctgactcatt
ctacgtctct cccatcttgt tacaataata 1560atttgggaga tcatattgaa
ggtcttaata aagtcaaggc atgtgatatt ctctgctttg 1620cctttgtttc
tagaataagc cacttcatca tagaagatga aaatgctgat cagcagagat
1680ctgtgcttga taaatccatg ctggcttttc ctatcacctt atattccttc
atatgccttg 1740agacacccaa ggaggccttg gatcagagct gtctgtagca
gtcctaactg gtatacaatt 1800agttgtacaa caggtagtga tccgcataat
agttggcgtg agaaagtggg cctgtgctgt 1860gtcaagcata gagtttgggt
tccagtcctg ttctgcatgg cacatatgcc tgagcagctg 1920ggtaatctct
gcattccaat tggaaggcag gggcctgtag gcagttccca cttggcatgg
1980gtgattgtac cacctgtgtc ctcatctgtg aagcatcatg ttttcattca
aatatccttt 2040tgtttgacag tagaaatgaa cagaattgtt tttttttcct
aagcaaattc tgcaagagct 2100ctgaagaaca aggtgtcagt gaacttctag
ctccatagat aggacttgca tcacatgtca 2160tgccttgatt ggaggtctat
ccgatactga acaacttgtg gttccctgag ggaatgtaag 2220attactgata
ctactctctc tttatgttag ctacaataaa tggtaggtta agcaatagat
2280acagagtttg agtgcctttc ttacaagcat catagtgaac aaatccactg
gtgatctacc 2340ttttcaataa ctacagagaa ttgtaatctc ttggattctc
ctccttcccc gttctgaaaa 2400tgtgttcttt ttttccaaat cagaaacctt
cctcaaccac cctgactatt ctttggacat 2460tgttttgttc ttgctcctaa
ataggcttta taatttttgt aagtgaaagg ctttgcatgc 2520aggtgaggct
acaactcatt cagtaacaat gaggaagact gtcagatttt ggggaaaatt
2580ctcccaccca accttttgct agccagtaag atgtaatcac tgaatgtcat
gccacaaaga 2640ccataccaac atcagaccac atatctacag gaagctttaa
ggaatcattg actgtacagt 2700gaagggtaaa tcaaattaaa atgaatgtga
ggtctgatac gagatatcct catgggaatc 2760aagagcaaag acaaatagtt
tttcacagtc ttgtcatgat ctgtcacaga ccaaggcagc 2820acagcaggca
acaatgttgg tctcttcaga atggcacagc accgctgcag aaaaatgcca
2880ggtggactat gaactcacat ccaaaggagc ttgacctgat acctgatttt
cttcaaacag 2940gggaaacaac acaatcccac aaaatagctc agagagaaac
catcactgat ggctacagca 3000ccaaggtatg caatggcaat ccattcgaca
ttcatctgtg acctgagcaa aatgatttat 3060ctctccatga atggttgctt
ctttccctca tgaaaaggca atttccacac tcacaatatg 3120caacaaagac
aaacagagaa caattaatgt gctccttcct aatgtcaaaa ttgtagtggc
3180aaagaggaga acaaaatctc aagttctgag taggttttag tgattggata
agaggctttg 3240acctgtgagc tcacctggac ttcatatcct tttggataaa
aagtgctttt ataactttca 3300ggtctccgag tctttattca tgagactgtt
ggtttaggga cagacccaca atgaaatgcc 3360tggcatagga aagggcagca
gagccttagc tgaccttttc ttgggacaag cattgtcaaa 3420caatgtgtga
caaaactatt tgtactgctt tgcacagctg tgctgggcag ggcaatccat
3480tgccacctat cccaggtaac cttccaactg caagaagatt gttgcttact
ctctctagac 3540ccccaagtca aaccaactat gcaggtatgc tgacaacgct
atgatgacag cctgttctga 3600tcaagatctc atttgttcat ggacaatttt
tgttgcttgc agctggtctt ccattgggaa 3660agagtgtagt atatccttct
catctgacag aaaagcagaa attctcatgc tccacactta 3720atctacattg
ttttaaacca ccagctactt cttggagagg aaaaatggct tttataagac
3780tcacaaaaca aagctctgca agtcaaatgc atacaaaact gttctgtagg
tctggaatca 3840ggacactatg tggaagtcaa atagagaagc tttaaaaaaa
cctttgggat cattctcatc 3900ttatatttgc agcacgatac tatgacagtg
ataactgaca taactgcatc aatttccttg 3960atattttatt tgtcttaaag
tacaagacat agagatggac gtaaagatgg acatatgact 4020caggtctgga
caggtccgtg gtccatgtat gataaaagag atgaagggaa ggagaatgga
4080gactgtctaa gaagggcttc agggacgttc tgaaggcaga tttgactgaa
tcagatgtac 4140tgtccaagtc tcatatgtag caatggaaga ctgatattgg
agaaatataa agaaatggct 4200gtgaactcaa agtgaccctg aacagaaaag
ggatatggag ttaaaataat ggcacagaac 4260tgaggtttat atgatatacc
atgggctgca gagggtcaga gtgctccacc atgggcctct 4320cttgggctgc
agggaacttc tgttctacac ctggaacacc tcctgccctc ctccgcactg
4380acctcagtgt catcagggct gtttctctca cattttctca ctcacctctc
ccaactacca 4440ttgtacagca gttgttctta catcttgctc ctcctgaggt
gcatctagca tcgatcactg 4500gctcagctct ggccagtggc agctcccttt
tgaggacacg ggacagctgc tgggctctgt 4560tcacagaggc cactccagca
gacctccact accacaactt gtagtgtaaa tccactacaa 4620ctttctgagc
tacagaaatg aaatggagac cctctctgct atgggataca aaagaggaaa
4680cgtggcgttt agtgctctgg ctcactggta cacccaacca cagggtgaga
agcagcctgt 4740tgttattcac tactcttagg acagattatg gtgaattgtt
aataaaagca tttcttcata 4800acatccaaag gaggaaatac actaaattat
attttttatt tattaattac acatgcttaa 4860ttatatatgg catggttgct
ttgaaagaac cttgtcctta ctgaccagat ctgctgtttg 4920ctgagacaaa
atggctgaca attttggcca tggtggatac cttccccctt ttctgtagca
4980ttaggacaga agttattctg gagcctgtct gacaagtcag acttgataac
tttaagtatt 5040tggaagtgtg cttttcatgc tggatgtcat ctccagaacc
tccctgtctg gtaagcagtt 5100ccctgcctta gtaagagccg aaacggtctc
tcttttcctt gttatctcac caggatatta 5160caatgtgaca ggactatctg
aactacgcca acctgcaaat tccaaatata tatatatata 5220tgtaagatat
ctatacacaa attattagtg tttgattgac accagatgac agagaagtgc
5280atctgagaaa acctattccc aatctccttt ctctttctgc agactgacat
gcatttcata 5340ggtagagata acatttactg ggaagcacat ctatcatcat
aaaaagcagg caagattttc 5400agactttctt agtggctgaa atagaagcaa
aagacgtgat taaaaacaaa atgaaacaaa 5460aaaaatcagt tgatacctgt
ggtgtagaca tccagcaaaa aaatattatt tgcactacca 5520tcttgtctta
agtcctcaga cttggcaagg agaatgtaga tttctacagt atatatgttt
5580tcacaaaagg aaggagagaa acaaaagaaa atggcactga ctaaacttca
gctagtggta 5640taggaaagta attctgctta acagagattg cagtgatctc
tatgtatgtc ctgaagaatt 5700atgttgtact tttttccccc atttttaaat
caaacagtgc tttacagagg tcagaatggt 5760ttctttactg tttgtcaatt
ctattatttc aatacagaac aatagcttct ataactgaaa 5820tatatttgct
attgtatatt atgattgtcc ctcgaaccat gaacactcct ccagctgaat
5880ttcacaattc ctctgtcatc tgccaggcca ttaagttatt catggaagat
ctttgaggaa 5940cactgcaagt tcatatcata aacacatttg aaattgagta
ttgttttgca ttgtatggag 6000ctatgttttg ctgtatcctc agaaaaaaag
tttgttataa agcattcaca cccataaaaa 6060gatagattta aatattccag
ctataggaaa gaaagtgcgt ctgctcttca ctctagtctc 6120agttggctcc
ttcacatgca tgcttcttta tttctcctat tttgtcaaga aaataatagg
6180tcacgtcttg ttctcactta tgtcctgcct agcatggctc agatgcacgt
tgtagataca 6240agaaggatca aatgaaacag acttctggtc tgttactaca
accatagtaa taagcacact 6300aactaataat tgctaattat gttttccatc
tctaaggttc ccacattttt ctgttttctt 6360aaagatccca ttatctggtt
gtaactgaag ctcaatggaa catgagcaat atttcccagt 6420cttctctccc
atccaacagt cctgatggat tagcagaaca ggcagaaaac acattgttac
6480ccagaattaa aaactaatat ttgctctcca ttcaatccaa aatggaccta
ttgaaactaa 6540aatctaaccc aatcccatta aatgatttct atggcgtcaa
aggtcaaact tctgaaggga 6600acctgtgggt gggtcacaat tcaggctata
tattccccag ggctcagcca gtgtctgtac 6660atacagctag aaagctgtat
tgcctttagc agtcaagctc gaaaggtaag caactctctg 6720gaattacctt
ctctctatat tagctcttac ttgcacctaa actttaaaaa attaacaatt
6780attgtgctat gtgttgtatc tttaagggtg aagtacctgc gtgatacccc
ctataaaaac 6840ttctcacctg tgtatgcatt ctgcactatt ttattatgtg
taaaagcttt gtgtttgttt 6900tcaggaggct tattctttgt gcttaaaata
tgtttttaat ttcagaacat cttatcctgt 6960cgttcactat ctgatatgct
ttgcagtttg cttgattaac ttctagccct acagagtgca 7020cagagagcaa
aatcatggtg ttcagtgaat tctggggagt tattttaatg tgaaaattct
7080ctagaagttt aattcctgca aagtgcagct gctgatcact acacaagata
aaaatgtggg 7140gggtgcataa acgtatattc ttacaataat agatacatgt
gaacttatat acagaaaaga 7200aaatgagaaa aatgtgtgtg tgtatactca
cacacgtggt cagtaaaaac ttttgagggg 7260tttaatacag
aaaatccaat cctgaggccc cagcactcag tacgcatata aagggctggg
7320ctctgaagga cttctgactt tcacagatta tataaatctc aggaaagcaa
ctagattcat 7380gctggctcca aaagctgtgc tttatataag cacactggct
atacaatagt tgtacagttc 7440agctctttat aatagaaaca gacagaacaa
gtataaatct tctattggtc tatgtcatga 7500acaagaattc attcagtggc
tctgttttat agtaaacatt gctattttat catgtctgca 7560tttctcttct
gtctgaatgt caccactaaa atttaactcc acagaaagtt tatactacag
7620tacacatgca tatctttgag caaagcaaac catacctgaa agtgcaatag
agcagaatat 7680gaattacatg cgtgtctttc tcctagacta catgacccca
tataaattac attacttatc 7740tattctgcca tcaccaaaac aaaggtaaaa
atacttttga agatctactc atagcaagta 7800gtgtgcaaca aacagatatt
tctctacatt tatttttagg gaataaaaat aagaaataaa 7860atagtcagca
agcctctgct ttctcatata tctgtccaaa cctaaagttt actgaaattt
7920gctctttgaa tttccagttt tgcaagccta tcagattgtg ttttaatcag
aggtactgaa 7980aagtatcaat gaattctagc tttcactgaa caaaaatatg
tagaggcaac tggcttctgg 8040gacagtttgc tacccaaaag acaactgaat
gcaaatacat aaatagattt atgaatatgg 8100ttttgaacat gcacatgaga
ggtggatata gcaacagaca cattaccaca gaattacttt 8160aaaactactt
gttaacattt aattgcctaa aaactgctcg taatttactg ttgtagccta
8220ccatagagta ccctgcatgg tactatgtac agcattccat ccttacattt
tcactgttct 8280gctgtttgct ctagacaact cagagttcac catgggctcc
atcggtgcag caagcatgga 8340attttgtttt gatgtattca aggagctcaa
agtccaccat gccaatgaga acatcttcta 8400ctgccccatt gccatcatgt
cagctctagc catggtatac ctgggtgcaa aagacagcac 8460caggacacaa
ataaataagg tgagcctaca gttaaagatt aaaacctttg ccctgctcaa
8520tggagccaca gcacttaatt gtatgataat gtcccttgga aactgcatag
ctcagaggct 8580gaaaatctga aaccagagtt atctaaaagt gtggccacct
ccaactccca gagtgttacc 8640caaatgcact agctagaaat cttgaaactg
gattgcataa cttctttttg tcataaccat 8700tatttcagct actattattt
tcaattacag gttgttcgct ttgataaact tccaggattc 8760ggagacagta
ttgaagctca ggtacagaaa taatttcacc tccttctcta tgtccctttc
8820ctctggaagc aaaatacagc agatgaagca atctcttagc tgttccaagc
cctctctgat 8880gagcagctag tgctctgcat ccagcagttg ggagaacact
gttcataaga acagagaaaa 8940agaaggaagt aacaggggat tcagaacaaa
cagaagataa aactcaggac aaaaataccg 9000tgtgaatgag gaaacttgtg
gatatttgta cgcttaagca agacagctag atgattctgg 9060ataaatgggt
ctggttggaa aagaaggaaa gcctggctga tctgctggag ctagattatt
9120gcagcaggta ggcaggagtt ccctagagaa aagtatgagg gaattacaga
agaaaaacag 9180cacaaaattg taaatattgg aaaaggacca catcagtgta
gttactagca gtaagacaga 9240caggatgaaa aatagttttg taaacagaag
tatctaacta ctttactctg ttcatacact 9300acgtaaaact tactaagtaa
taaaactaga ataacaacat ctttctttct ctttgtattc 9360agtgtggcac
atctgtaaac gttcactctt cacttagaga catcctcaac caaatcacca
9420aaccaaatga tgtttattcg ttcagccttg ccagtagact ttatgctgaa
gagagatacc 9480caatcctgcc agtaagttgc tctaaaatct gatctgagtg
tattccatgc caaagctcta 9540ccattctgta atgcaaaaac agtcagagtt
ccacatgttt cactaagaaa atttcttttt 9600ctcttgtttt tacaaatgaa
agagaggaca aataacattt ctctatcacc gacctgaaac 9660tctacagtct
tcagagaatg aatggcttgc taaaagaatg tcaaatctta ctatacagct
9720atttcatatt acactactaa atacactata aggcatagca tgtagtaata
cagtgtaaaa 9780tagcttttta cactactata ttattaatat ctgttaattc
cagtcttgca tttcacattt 9840gcaaaacgtt ttgaaattcg tatctgaaag
ctgaatactc ttgctttaca ggaatacttg 9900cagtgtgtga aggaactgta
tagaggaggc ttggaaccta tcaactttca aacagctgca 9960gatcaagcca
gagagctcat caattcctgg gtagaaagtc agacaaatgg taaggtagaa
10020catgctttgt acatagtgag agttggttca ccctaatact gagaacttgg
atatagctca 10080gccagcgtgc tttgcgttca agcttaccag agctgttgta
tgcctgttaa gcagggcata 10140cagtcatgag gctcttgaaa aatcttaaca
gacaaagggc aatggaaaat cggagttaag 10200ggatggtagg gataaaatgc
atagaaagag gtaccacaat tttgattttt gccctaatgc 10260ctctctgcgt
ggttcctcaa tttttctact tcattcctca tctcctcaga gcattccttt
10320ccctcatgct tgaaacacag atgaaagact gtgaattcta actgagatga
aaacatccac 10380aaccacacaa cctctggtgt ggagtcacat tctgtgaagg
caaaaactag gccacgtaat 10440ctatgcgtgc aagctacgcg taagctatgt
gtgtgacagg acaatgtgag gaacatacta 10500tgtgcacaag gactgcagaa
taaacaggag caaagttttt gaagaaaaca gagtaaaatc 10560ctgttttcct
cttttgttac attctttaca tatatctcaa atttcctctt tggttagaag
10620caagtaatat ttatgtttct tggtactgtt tgggttgaag accattctgg
gataagagaa 10680attccagtgg ttcttcccct aatcataaaa tgtcaggttt
agtttttttg taacacagaa 10740atctcttcat cttttatctt ttgttgtgat
tcttgataga gagagaaaca agacttactg 10800acaatagcag caagaaaatc
aatcttggaa gaacaagatt gcaattgcaa aaacaaacca 10860atgtccttgc
ccctacatcc tcttccccat aaattctaca ttctctatct accttgtgct
10920tgccaacatg atatacgtaa actctctttt cctattcatt cttaaaggaa
ttatcagaaa 10980tgtccttcag ccaagctccg tggattctca aactgcaatg
gttctggtta atgccattgt 11040cttcaaagga ctgtgggaga aagcatttaa
ggatgaagac acacaagcaa tgcctttcag 11100agtgactgag gtatatgggc
ataccttaga gatgtaatct agaatttatg aagagagtag 11160acatgttgtt
atatgaacac tgcattagcg tatctgctca tttgtctgca tctctttcag
11220acactgtgtt aaaagcaggg aattttcctt atgtctctct cgtcacaata
ttcctgacat 11280tgcaaagctc ctgagaaata acttcagatt ccacttttcc
taggaaggct tctggatgag 11340aactaatcat cttaactgta actagacatt
tctgcatcca agaataatct ttgttaaaac 11400tatattctct ctctcttttt
tttttttttt tggttctcca gcaagaaagc aaacctgtgc 11460agatgatgta
ccagattggt ttatttagag tggcatcaat ggcttctgag aaaatgaaga
11520tcctggagct tccatttgcc agtgggacaa tgagcatgtt ggtgctgttg
cctgatgaag 11580tctcaggcct tgagcaggta tggccctaga agttggcttc
agaatattaa aaacacatgg 11640aaatttagct gttgtaaagc tcttttcaac
acagttatcc taaaacattt aaccagcaca 11700aatttcatca tgattcaata
tgtgattgtt gcatagaagt gtagatttgt cccactgggt 11760cctgcaatag
cccatgctga gcatggcttg ctgaaagaac tgctttagag ggtgaaaagt
11820ttgacacagc agacaagatg attctcacct aagcagctgt tactgtagtg
gcttgaactc 11880taaaggtctt gtatctccat tcctgtgcac tgaggagctt
cttggaaagt tcatataagg 11940tttactagtt ctaactatta tctcatttgg
tggcactcaa tgtgctttgt tcacgtcttc 12000ataaattaat ctatctaaaa
attggatgtg gttaaagcaa tttcagaaat aacatgtaca 12060taatgtacaa
ttattgatat gaacagaaca caggcatagc atattgtaat taggaggact
12120gtagttattt tgaataggaa acacaatgta ataaatgaga attcattgaa
atgttagtat 12180gctaactcaa tctaaattat aaagataaag aggcatttaa
tcacagctag atttccatca 12240cttgtgacag acaggcatat gaatgattat
gtacagctct aggaaaaaaa gtatgtagga 12300aaactagtac attttgatta
gaaagtctga aaatgaggtg ccttgatcaa agagaatacg 12360tgtgtttgag
aaaaaaaaag tttggataga ggtggtaaga gagaatatat tgaaatggtg
12420tttctacaaa ctgccatggc cagatttgtg taagagacat tcagtaagta
ggcaaggaaa 12480gaaatattac taggtacaaa gcaacatcag taataccaaa
agaaaccaat tattccagat 12540gccaatctcg taatagggtt aagagatttc
cacccctcta gtggtcacca gtgcaaccag 12600taactttgct aatttacatt
ttcttttttt aaatggcaga tatagctttg aactgagtga 12660tcatgaactg
gtactgtgta atagatgaag acatacttga cgactaaact tctgattttt
12720aaaaactcaa attctcttga aagatcagtt cccagtctag taacagctga
tagtttaagt 12780atcagtaatt ggctaccatt aacaactggc tcctgagagg
tcttaaatgt agagacagct 12840ttaaactcaa aagcacagag tgatttttag
aatagatttc ccaagcaaag aaaataaaca 12900gggaggagct ttaagggagt
agccatctca ttattattat tatttaaaga aatggcagca 12960agcctacaaa
agaaaaataa gacagagcag agaagaaaga gtcatggtat gcttttctat
13020cttagcaaaa ttaatctcta catgcctagg aaaaagccat gacaagagca
atcagttcaa 13080aaggtgtatg caaaaaacca cataatagta actagtactg
cattgccagg aaggaagtta 13140tgtcgccatt ccatggatct cattctcatt
tccttgcagc ttgagagtat aatcaacttt 13200gaaaaactga ctgaatggac
cagttctaat gttatggaag agaggaagat caaagtgtac 13260ttacctcgca
tgaagatgga ggaaaaatac aacctcacat ctgtcttaat ggctatgggc
13320attactgacg tgtttagctc ttcagccaat ctgtctggca tctcctcagc
agagagcctg 13380aagatatctc aagctgtcca tgcagcacat gcagaaatca
atgaagcagg cagagaggtg 13440gtagggtcag cagaggctgg agtggatgct
gcaagcgtct ctgaagaatt tagggctgac 13500catccattcc tcttctgtat
caagcacatc gcaaccaacg ccgttctctt ctttggcaga 13560tgtgtttccc
cttaaaaaga agaaagctga aaaactctgt cccttccaac aagacccaga
13620gcactgtagt atcaggggta aaatgaaaag tatgttatct gctgcatcca
gacttcataa 13680aagctggagc ttaatctaga aaaaaaatca gaaagaaatt
acactgtgag aacaggtgca 13740attcactttt cctttacaca gagtaatact
ggtaactcat ggatgaaggc ttaagggaat 13800gaaattggac tcacagtact
gagtcatcac actgaaaaat gcaacctgat acatcagcag 13860aaggtttatg
ggggaaaaat gcagccttcc aattaagcca gatatctgta tgaccaagct
13920gctccagaat tagtcactca aaatctctca gattaaatta tcaactgtca
ccaaccattc 13980ctatgctgac aaggcaattg cttgttctct gtgttcctga
tactacaagg ctcttcctga 14040cttcctaaag atgcattata aaaatcttat
aattcacatt tctccctaaa ctttgactca 14100atcatggtat gttggcaaat
atggtatatt actattcaaa ttgttttcct tgtacccata 14160tgtaatgggt
cttgtgaatg tgctcttttg ttcctttaat cataataaaa acatgtttaa
14220gcaaacactt ttcacttgta gtatttgaag tacagcaagg ttgtgtagca
gggaaagaat 14280gacatgcaga ggaataagta tggacacaca ggctagcagc
gactgtagaa caagtactag 14340tgggtgagaa gttgaacaag agtcccctac
aagcaactta atctaataag ctagtggtct 14400acatcagcta aaagagcata
gtgagggatg aaattggttc tcctttctaa gcatcacctg 14460ggacaactca
tctggagcag tgtgtccaat ctgccgctgc cctgatctcg gctggggtga
14520tgggacagac cttggctgcc actgagacat ctgagacact gagatctgtc
tcaactcaga 14580tttacccaag aacagctcat tgccaacaga acaaaatctc
aaacttatgg ctagtgatga 14640cagcagtcag ttgtcccatc tgtgacccac
caaggctggc atgctggaat gagcaggctt 14700tggtggcatg tagttactgg
acagcaccac tgacatgggc aggggaaaaa ctgagcatgg 14760tgtaaatcac
tgcctcaaag ccacttctct gtgcctgcac catgcttgaa agctcttcta
14820caggagctgg gtttgttcaa gaaagcttct gtttctccca tctgcttctt
gtaccttcac 14880agggacagag ttagaagggt acagccatgg ctggaagggg
ctgactttca aatgtgccta 14940attttccttt ggttgctgct gcagctgcag
aagaaggggt tcagaagcca agagctttga 15000gataaggatg cctaacctat
gttgaagaca tttgtgctga cacctcaggc cccaggatag 15060gacaactgct
ggattgtggc taacccacta gctacagaac ctaatttata ttaccagatt
15120aggaagagca aaagaacatg tatttataac aggaggtctt ctgtgcttct
ctactaaaag 15180gtgctgtgaa ggagcccaca gtgcagcagt gtatgaggcc
tgaaagaggc cgcagcacac 15240gaagagccct ggtaggagca gcacacagag
gggcaggagg gctgggggaa ctgccaccca 15300tggggacctg tgtgaagcag
tgcactcctg aggggtggac tgcgtgggaa aggaaaagaa 15360agcaaacaga
cctgtgatga actgtcacac agactgcaga gtgacagagg agggcacgag
15420gcagtgcgcc cactgcaggg agtggcgctc cttcctcaca gcagcgctaa
cagcttggca 15480ccaatattca gtagtctgtg gtgatacttt ttccagtttc
accacacagc atttcgcttg 15540ttctacttgt tttagctttc cccctccaca
agataacaca tactttgcca gtcagtccct 15600aagaccttaa cttaacagtt
agcaaacagg atcttgcaaa agaaggaaga taacatgaca 15660ccaccttcac
tggtgtataa atagttcaaa tactttcctt cactttcccg taaattagtt
15720gattgcaggt caggagataa caggggaact tactgcaaga gagaaaatga
tgtttaatat 15780tgtcttggac tttctggtgg tctgggcatg aaaatggggt
actcaaaatc ctcgggacgt 15840ttatttttca cctgatttat tcccaaactg
cactatttct aggccattgg agttcttatc 15900aattaaatta tactttggct
ctctgctatc tcactccctt tcatcttcag catcactttc 15960agcacaatta
caggagaaga cttagactca gagctttagg actcatcata agaggctttc
16020attgctctgt caccacaccc catatagatc t 16051237334DNAArtificial
SequencepBS-OM-4.4 Vector 23atcaagctta tcgataccgt cgacctcgag
ggggggcccg gtacccagct tttgttccct 60ttagtgaggg ttaatttcga gcttggcgta
atcatggtca tagctgtttc ctgtgtgaaa 120ttgttatccg ctcacaattc
cacacaacat acgagccgga agcataaagt gtaaagcctg 180gggtgcctaa
tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca
240gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg
ggagaggcgg 300tttgcgtatt gggcgctctt ccgcttcctc gctcactgac
tcgctgcgct cggtcgttcg 360gctgcggcga gcggtatcag ctcactcaaa
ggcggtaata cggttatcca cagaatcagg 420ggataacgca ggaaagaaca
tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa 480ggccgcgttg
ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg
540acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg
cgtttccccc 600tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg
cttaccggat acctgtccgc 660ctttctccct tcgggaagcg tggcgctttc
tcatagctca cgctgtaggt atctcagttc 720ggtgtaggtc gttcgctcca
agctgggctg tgtgcacgaa ccccccgttc agcccgaccg 780ctgcgcctta
tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc
840actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg
gtgctacaga 900gttcttgaag tggtggccta actacggcta cactagaagg
acagtatttg gtatctgcgc 960tctgctgaag ccagttacct tcggaaaaag
agttggtagc tcttgatccg gcaaacaaac 1020caccgctggt agcggtggtt
tttttgtttg caagcagcag attacgcgca gaaaaaaagg 1080atctcaagaa
gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc
1140acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga
tccttttaaa 1200ttaaaaatga agttttaaat caatctaaag tatatatgag
taaacttggt ctgacagtta 1260ccaatgctta atcagtgagg cacctatctc
agcgatctgt ctatttcgtt catccatagt 1320tgcctgactc cccgtcgtgt
agataactac gatacgggag ggcttaccat ctggccccag 1380tgctgcaatg
ataccgcgag acccacgctc accggctcca gatttatcag caataaacca
1440gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct
ccatccagtc 1500tattaattgt tgccgggaag ctagagtaag tagttcgcca
gttaatagtt tgcgcaacgt 1560tgttgccatt gctacaggca tcgtggtgtc
acgctcgtcg tttggtatgg cttcattcag 1620ctccggttcc caacgatcaa
ggcgagttac atgatccccc atgttgtgca aaaaagcggt 1680tagctccttc
ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat
1740ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat
gcttttctgt 1800gactggtgag tactcaacca agtcattctg agaatagtgt
atgcggcgac cgagttgctc 1860ttgcccggcg tcaatacggg ataataccgc
gccacatagc agaactttaa aagtgctcat 1920cattggaaaa cgttcttcgg
ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag 1980ttcgatgtaa
cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt
2040ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa
gggcgacacg 2100gaaatgttga atactcatac tcttcctttt tcaatattat
tgaagcattt atcagggtta 2160ttgtctcatg agcggataca tatttgaatg
tatttagaaa aataaacaaa taggggttcc 2220gcgcacattt ccccgaaaag
tgccacctaa attgtaagcg ttaatatttt gttaaaattc 2280gcgttaaatt
tttgttaaat cagctcattt tttaaccaat aggccgaaat cggcaaaatc
2340ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt
ttggaacaag 2400agtccactat taaagaacgt ggactccaac gtcaaagggc
gaaaaaccgt ctatcagggc 2460gatggcccac tacgtgaacc atcaccctaa
tcaagttttt tggggtcgag gtgccgtaaa 2520gcactaaatc ggaaccctaa
agggagcccc cgatttagag cttgacgggg aaagccggcg 2580aacgtggcga
gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt
2640gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc
gctacagggc 2700gcgtcccatt cgccattcag gctgcgcaac tgttgggaag
ggcgatcggt gcgggcctct 2760tcgctattac gccagctggc gaaaggggga
tgtgctgcaa ggcgattaag ttgggtaacg 2820ccagggtttt cccagtcacg
acgttgtaaa acgacggcca gtgaattgta atacgactca 2880ctatagggcg
aattggagct ccaccgcggt ggcggccgct ctagaactag tggatccttc
2940ttaaaaagca gaccatcatt cactgcaaac ccagagcttc atgcctctcc
ttccacaacc 3000gaaaacagcc ggcttcattt gtctttttta aatgctgttt
tccaggtgaa ttttggccag 3060cgtgttggct gagatccagg agcacgtgtc
agctttctgc tctcattgct cctgttctgc 3120attgcctctt tctggggttt
ccaagagggg gggagacttt gcgcggggat gagataatgc 3180cccttttctt
agggtggctg ctgggcagca gagtggctct gggtcactgt ggcaccaatg
3240ggaggcacca gtgggggtgt gttttgtgca ggggggaagc attcacagaa
tggggctgat 3300cctgaagctt gcagtccaag gctttgtctg tgtacccagt
gaaatccttc ctctgttaca 3360taaagcccag ataggactca gaaatgtagt
cattccagcc cccctcttcc tcagatctgg 3420agcagcactt gtttgcagcc
agtcctcccc aaaatgcaca gacctcgccg agtggaggga 3480gatgtaaaca
gcgaaggtta attacctcct tgtcaaaaac actttgtggt ccatagatgt
3540ttctgtcaat cttacaaaac agaaccgaga ggcagcgagc actgaagagc
gtgttcccat 3600gctgagttaa tgagacttgg cagctcgctg tgcagagatg
atccctgtgc ttcatgggag 3660gctgtaacct gtctccccat cgccttcaca
ccgcagtgct gtcctggaca cctcaccctc 3720cataagctgt aggatgcagc
tgcccaggga tcaagagact tttcctaagg ctcttaggac 3780tcatctttgc
cgctcagtag cgtgcagcaa ttactcatcc caactatact gaatgggttt
3840ctgccagctc tgcttgtttg tcaataagca tttcttcatt ttgcctctaa
gtttctctca 3900gcagcaccgc tctgggtgac ctgagtggcc acctggaacc
cgaggggcac agccaccacc 3960tccctgttgc tgctgctcca gggactcatg
tgctgctgga tggggggaag catgaagttc 4020ctcacccaga cacctgggtt
gcaatggctg cagcgtgctc ttcttggtat gcagattgtt 4080tccagccatt
acttgtagaa atgtgctgtg gaagcccttt gtatctcttt ctgtggccct
4140tcagcaaaag ctgtgggaaa gctctgaggc tgctttcttg ggtcgtggag
gaattgtatg 4200ttccttcttt aacaaaaatt atccttagga gagagcactg
tgcaagcatt gtgcacataa 4260aacaattcag gttgaaaggg ctctctggag
gtttccagcc tgactactgc tcgaagcaag 4320gccaggttca aagatggctc
aggatgctgt gtgccttcct gattatctgt gccaccaatg 4380gaggagattc
acagccactc tgcttcccgt gccactcatg gagaggaata ttcccttata
4440ttcagataga atgttatcct ttagctcagc cttccctata accccatgag
ggagctgcag 4500atccccatac tctccccttc tctggggtga aggccgtgtc
ccccagcccc ccttcccacc 4560ctgtgcccta agcagcccgc tggcctctgc
tggatgtgtg cctatatgtc aatgcctgtc 4620cttgcagtcc agcctgggac
atttaattca tcaccagggt aatgtggaac tgtgtcatct 4680tcccctgcag
ggtacaaagt tctgcacggg gtcctttcgg ttcaggaaaa ccttcactgg
4740tgctacctga atcaagctct atttaataag ttcataagca catggatgtg
ttttcctaga 4800gatacgtttt aatggtatca gtgattttta tttgctttgt
tgcttacttc aaacagtgcc 4860tttgggcagg aggtgaggga cgggtctgcc
gttggctctg cagtgatttc tccaggcgtg 4920tggctcaggt cagatagtgg
tcactctgtg gccagaagaa ggacaaagat ggaaattgca 4980gattgagtca
cgttaagcag gcatcttgga gtgatttgag gcagtttcat gaaagagcta
5040cgaccactta ttgttgtttt ccccttttac aacagaagtt ttcatcaaaa
taacgtggca 5100aagcccagga atgtttggga aaagtgtagt taaatgtttt
gtaattcatt tgtcggagtg 5160ctaccagcta agaaaaaagt cctacctttg
gtatggtagt cctgcagaga atacaacatc 5220aatattagtt tggaaaaaaa
caccaccacc accagaaact gtaatggaaa atgtaaacca 5280agaaattcct
tgggtaagag agaaaggatg tcgtatactg gccaagtcct gcccagctgt
5340cagcctgctg accctctgca gttcaggacc atgaaacgtg gcactgtaag
acgtgtcccc 5400tgcctttgct tgcccacaga tctctgccct tgtgctgact
cctgcacaca agagcatttc 5460cctgtagcca aacagcgatt agccataagc
tgcacctgac tttgaggatt aagagtttgc 5520aattaagtgg attgcagcag
gagatcagtg gcagggttgc agatgaaatc cttttctagg 5580ggtagctaag
ggctgagcaa cctgtcctac agcacaagcc aaaccagcca agggttttcc
5640tgtgctgttc acagaggcag ggccagctgg agctggagga ggttgtgctg
ggacccttct 5700ccctgtgctg agaatggagt gatttctggg tgctgttcct
gtggcttgca ctgagcagct 5760caagggagat cggtgctcct catgcagtgc
caaaactcgt gtttgatgca gaaagatgga 5820tgtgcacctc cctcctgcta
atgcagccgt gagcttatga aggcaatgag ccctcagtgc 5880agcaggagct
gtagtgcact cctgtaggtg ctagggaaaa tctctggttc ccagggatgc
5940attcataagg gcaatatatc ttgaggctgc gccaaatctt tctgaaatat
tcatgcgtgt 6000tcccttaatt tatagaaaca aacacagcag aataattatt
ccaatgcctc ccctcgaagg 6060aaacccatat ttccatgtag aaatgtaacc
tatatacaca cagccatgct gcatccttca 6120gaacgtgcca gtgctcatct
cccatggcaa aatactacag gtattctcac tatgttggac 6180ctgtgaaagg
aaccatggta agaaacttcg gttaaaggta tggctgcaaa actactcata
6240ccaaaacagc agagctccag acctcctctt aggaaagagc cacttggaga
gggatggtgt 6300gaaggctgga ggtgagagac agagcctgtc ccagttttcc
tgtctctatt ttctgaaacg 6360tttgcaggag gaaaggacaa ctgtactttc
aggcatagct ggtgccctca cgtaaataag 6420ttccccgaac ttctgtgtca
tttgttctta agatgctttg gcagaacact ttgagtcaat 6480tcgcttaact
gtgactaggt ctgtaaataa gtgctccctg ctgataaggt tcaagtgaca
6540tttttagtgg tatttgacag catttacctt gctttcaagt cttctaccaa
gctcttctat 6600acttaagcag tgaaaccgcc aagaaaccct tccttttatc
aagctagtgc taaataccat 6660taacttcata ggttagatac ggtgctgcca
gcttcacctg gcagtggttg gtcagttctg 6720ctggtgacaa agcctccctg
gcctgtgctt ttacctagag gtgaatatcc aagaatgcag 6780aactgcatgg
aaagcagagc tgcaggcacg atggtgctga gccttagctg cttcctgctg
6840ggagatgtgg atgcagagac gaatgaagga cctgtccctt actcccctca
gcattctgtg 6900ctatttaggg ttctaccaga gtccttaaga ggtttttttt
ttttttggtc caaaagtctg 6960tttgtttggt tttgaccact gagagcatgt
gacacttgtc tcaagctatt aaccaagtgt 7020ccagccaaaa tcaattgcct
gggagacgca gaccattacc tggaggtcag gacctcaata 7080aatattacca
gcctcattgt gccgctgaca gattcagctg gctgctccgt gttccagtcc
7140aacagttcgg acgccacgtt tgtatatatt tgcaggcagc ctcgggggga
ccatctcagg 7200agcagagcac cggcagccgc ctgcagagcc gggcagtacc
tcaccatggc catggcaggt 7260gtcttcgtgc tgttctcttt cgtgctttgt
ggcttcctcc caggtgagta actcccagag 7320tgctgcagaa gctt
7334244327DNAArtificial SequencepAVIJCR-A137.91.1.2 Vector
24gccaatgtgg tacttcccac attgtataag aaatttggca agtttagagc aatgtttgaa
60gtgttgggaa atttctgtat actcaagagg gcgtttttga caactgtaga acagaggaat
120caaaaggggg tgggaggaag ttaaaagaag aggcaggtgc aagagagctt
gcagtcccgc 180tgtgtgtacg acactggcac catggctttg acctttgcct
tactggtggc tctcctggtg 240ctgagctgca agagcagctg ctctgtgggc
tgcgatctgc ctcagaccca cagcctgggc 300agcaggagga ccctgatgct
gctggctcag atgaggagaa tcagcctgtt tagctgcctg 360aaggataggc
acgattttgg ctttcctcaa gaggagtttg gcaaccagtt tcagaaggct
420gagaccatcc ctgtgctgca cgagatgatc cagcagatct ttaacctgtt
tagcaccaag 480gatagcagcg ctgcttggga tgagaccctg ctggataagt
tttacaccga gctgtaccag 540cagctgaacg atctggaggc ttgcgtgatc
cagggcgtgg gcgtgaccga gacccctctg 600atgaaggagg atagcatcct
ggctgtgagg aagtactttc agaggatcac cctgtacctg 660aaggagaaga
agtacagccc ctgcgcttgg gaagtcgtga gggctgagat catgaggagc
720tttagcctga gcaccaacct gcaagagagc ttgaggtcta aggagtaaaa
agtctagagt 780cggggcggcc ggccgcttcg agcagacatg ataagataca
ttgatgagtt tggacaaacc 840acaactagaa tgcagtgaaa aaaatgcttt
atttgtgaaa tttgtgatgc tattgcttta 900tttgtaacca ttataagctg
caataaacaa gttaacaaca acaattgcat tcattttatg 960tttcaggttc
agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt
1020ggtaaaatcg ataaggatcc gtcgaccgat gcccttgaga gccttcaacc
cagtcagctc 1080cttccggtgg gcgcggggca tgactatcgt cgccgcactt
atgactgtct tctttatcat 1140gcaactcgta ggacaggtgc cggcagcgct
cttccgcttc ctcgctcact gactcgctgc 1200gctcggtcgt tcggctgcgg
cgagcggtat cagctcactc aaaggcggta atacggttat 1260ccacagaatc
aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca
1320ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc
cctgacgagc 1380atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc
gacaggacta taaagatacc 1440aggcgtttcc ccctggaagc tccctcgtgc
gctctcctgt tccgaccctg ccgcttaccg 1500gatacctgtc cgcctttctc
ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta 1560ggtatctcag
ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg
1620ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac
ccggtaagac 1680acgacttatc gccactggca gcagccactg gtaacaggat
tagcagagcg aggtatgtag 1740gcggtgctac agagttcttg aagtggtggc
ctaactacgg ctacactaga aggacagtat 1800ttggtatctg cgctctgctg
aagccagtta ccttcggaaa aagagttggt agctcttgat 1860ccggcaaaca
aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc
1920gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct
gacgctcagt 1980ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt
atcaaaaagg atcttcacct 2040agatcctttt aaattaaaaa tgaagtttta
aatcaatcta aagtatatat gagtaaactt 2100ggtctgacag ttaccaatgc
ttaatcagtg aggcacctat ctcagcgatc tgtctatttc 2160gttcatccat
agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac
2220catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct
ccagatttat 2280cagcaataaa ccagccagcc ggaagggccg agcgcagaag
tggtcctgca actttatccg 2340cctccatcca gtctattaat tgttgccggg
aagctagagt aagtagttcg ccagttaata 2400gtttgcgcaa cgttgttgcc
attgctacag gcatcgtggt gtcacgctcg tcgtttggta 2460tggcttcatt
cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt
2520gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag
ttggccgcag 2580tgttatcact catggttatg gcagcactgc ataattctct
tactgtcatg ccatccgtaa 2640gatgcttttc tgtgactggt gagtactcaa
ccaagtcatt ctgagaatag tgtatgcggc 2700gaccgagttg ctcttgcccg
gcgtcaatac gggataatac cgcgccacat agcagaactt 2760taaaagtgct
catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc
2820tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca
gcatctttta 2880ctttcaccag cgtttctggg tgagcaaaaa caggaaggca
aaatgccgca aaaaagggaa 2940taagggcgac acggaaatgt tgaatactca
tactcttcct ttttcaatat tattgaagca 3000tttatcaggg ttattgtctc
atgagcggat acatatttga atgtatttag aaaaataaac 3060aaataggggt
tccgcgcaca tttccccgaa aagtgccacc tgacgcgccc tgtagcggcg
3120cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt
gccagcgccc 3180tagcgcccgc tcctttcgct ttcttccctt cctttctcgc
cacgttcgcc ggctttcccc 3240gtcaagctct aaatcggggg ctccctttag
ggttccgatt tagtgcttta cggcacctcg 3300accccaaaaa acttgattag
ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg 3360tttttcgccc
tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg
3420gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt
ttgccgattt 3480cggcctattg gttaaaaaat gagctgattt aacaaaaatt
taacgcgaat tttaacaaaa 3540tattaacgtt tacaatttcc cattcgccat
tcaggctgcg caactgttgg gaagggcgat 3600cggtgcgggc ctcttcgcta
ttacgccagc ccaagctacc atgataagta agtaatatta 3660aggtacggga
ggtacttgga gcggccgcaa taaaatatct ttattttcat tacatctgtg
3720tgttggtttt ttgtgtgaat cgatagtact aacatacgct ctccatcaaa
acaaaacgaa 3780acaaaacaaa ctagcaaaat aggctgtccc cagtgcaagt
gcaggtgcca gaacatttct 3840ctatcgatag gtaccgagct cttacgcgtg
ctagccccga tgtacgggcc agatatacgc 3900gttgacattg attattgact
agttattaat agtaatcaat tacggggtca ttagttcata 3960gcccatatat
ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc
4020ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta
acgccaatag 4080ggactttcca ttgacgtcaa tgggtggact atttacggta
aactgcccac ttggcagtac 4140atcaagtgta tcatatgcca agtacgcccc
ctattgacgt caatgacggt aaatggcccg 4200cctggcatta tgcccagtac
atgaccttat gggactttcc tacttggcag tacatctacg 4260tattagtcat
cgctattacc atgcatggct ttgacctttg ccttactggt ggctctcctg 4320gtgctta
432725244DNAArtificial SequenceThe RRE (rev responsive element)
sequence 25aattgaggag ctttgttcct tgggttcttg ggagcagcag gaagcactat
gggcgcagcg 60tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca
gcagcagaac 120aatttgctga gggctattga ggcgcaacag catctgttgc
aactcacagt ctggggcatc 180aagcagctcc aggcaagaat cctggctgtg
gaaagatacc taaaggatca acagctcctg 240gtac 24426158DNAArtificial
SequenceThe ALV CTE (constitutive transport element) sequence
26aatgtgggga gggcaaggct tgcgaatcgg gttgtaacgg gcaaggcttg actgagggga
60caatagcatg tttaggcgaa aagcggggct tcggttgtac gcggttagga gtcccctcag
120gatatagtag tttcgctttt gcatagggag ggggaaat 1582755DNAArtificial
Sequencep10.0-OM-IFN-1 Primer 27ggcgtcgacg gatccgttaa ccctagaact
agtggatctc tgcccttgtg ctgac 552831DNAArtificial
Sequencep10.0-OM-IFN-2 28ggcctcgagc ctagactttt tactccttag a
3129346DNAArtificial SequenceALV vector 5' LTR sequence
29aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg cttatgtaac gatgagttag
60caacatgcct tataaggaga gaaaaagcac cgtgcatgcc gattggtggg agtaaggtgg
120tatgatcgtg gtatgatcgt gccttgttag gaaggcaaca gacgggtcta
acacggattg 180gacgaaccac tgaattccgc attgcagaga tattgtattt
aagtgcctag ctcgatacaa 240taaacgccat ttgaccattc accacattgg
tgtgcacctg ggttgatggc cggaccgttg 300attccctgrc gactacgagc
acatgcatga agcagaaggc ttcatt 346
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.