U.S. patent application number 13/857196 was filed with the patent office on 2013-10-10 for proteins toxic to hemipteran insect species. This patent application is currently assigned to MONSANTO TECHNOLOGY LLC. The applicant listed for this patent is James A. Baum, Artem G. Evdokimov, Farhad Moshiri, Timothy J. Rydel, Eric J. Sturman, Moritz von Rechenberg, Halong Vu, Andrew M. Wollacott, Meiying Zheng. Invention is credited to James A. Baum, Artem G. Evdokimov, Farhad Moshiri, Timothy J. Rydel, Eric J. Sturman, Moritz von Rechenberg, Halong Vu, Andrew M. Wollacott, Meiying Zheng.
Application Number | 20130269060 13/857196 |
Document ID | / |
Family ID | 49293388 |
Filed Date | 2013-10-10 |
United States Patent Application | 20130269060 |
Kind Code | A1 |
Baum; James A. ; et al. | October 10, 2013 |
The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
Inventors: | Baum; James A.; (Webster Groves, MO) ; Evdokimov; Artem G.; (St. Louis, MO) ; Moshiri; Farhad; (St. Louis, MO) ; Rydel; Timothy J.; (St. Louis, MO) ; Sturman; Eric J.; (St. Louis, MO) ; von Rechenberg; Moritz; (Waltham, MA) ; Vu; Halong; (St. Louis, MO) ; Wollacott; Andrew M.; (St. Louis, MO) ; Zheng; Meiying; (St. Louis, MO) | ||||||||||
Applicant: |
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Assignee: | MONSANTO TECHNOLOGY LLC St. Louis MO |
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Family ID: | 49293388 | ||||||||||
Appl. No.: | 13/857196 | ||||||||||
Filed: | April 5, 2013 |
Application Number | Filing Date | Patent Number | ||
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61621436 | Apr 6, 2012 | |||
Current U.S. Class: | 800/279 ; 426/635; 426/640; 435/419; 514/4.5; 530/350; 536/23.1; 554/1 |
Current CPC Class: | C07K 14/001 20130101; C07K 14/325 20130101; Y02A 40/146 20180101; A01N 37/46 20130101; C12N 15/8286 20130101; C07K 14/43577 20130101; C07K 14/32 20130101; A01N 63/10 20200101 |
Class at Publication: | 800/279 ; 530/350; 514/4.5; 536/23.1; 435/419; 554/1; 426/635; 426/640 |
International Class: | C12N 15/82 20060101 C12N015/82; C07K 14/00 20060101 C07K014/00 |
Sequence CWU 1
1
2061927DNABacillus thuringiensismisc_featureA sequence representing
a recombinant polynucleotide derived from a native gene from a
Bacillus thuringiensis (Bt) species encoding a TIC807 protein.
1atggctatcc tagaccttaa gtccctcgtg ctgaacgcca ttaactactg gggccctaag
60aacaacaacg gcatccaggg cggtgacttc ggctacccca tctctgagaa gcagatcgac
120actagcatca ttaccttcac ccaccctcgc ttgatcccct acgatcttac
tatcccgcag 180aaccttgaga ccatcttcac cacaacgcag gtgctcacca
ataacactga cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc
actaccacga cctcaactag cacgaccaac 300ggttggacag aaggaggcaa
gatcagcgac acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg
gtgagggtgg cgggaagaac tcgactacca tagaggccaa cttcgcacac
420aactctagca ccactacctt ccagcaagca agcactgaca ttgagtggaa
cattagccaa 480ccggtgctgg ttcctccctc taaacaagtt gtcgcgaccc
ttgtgatcat gggaggcaac 540tttaccatcc ctatggactt gatgaccacg
attgatagta cagagcacta ctcccactac 600tccggttacc ctatcctcac
ctggatctcg tccccagata actcttactc cggtcccttt 660atgtcatggt
actttgcaaa ctggcctaac cttccgagtg gattcggccc actgaatagt
720gataacacgg tcacatacac tggctctgtc gtgtcccaag tttcggccgg
tgtctacgct 780accgtccggt tcgatcagta tgacattcac aatctccgta
ctatcgagaa gacttggtat 840gctcgccatg cgacgctgca taatggcaag
aagatttcta tcaacaatgt cacggaaatg 900gctccaacat cccctatcaa gacaaat
9272309PRTArtificial Sequenceengineered 2Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys
Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300
Pro Ile Lys Thr Asn 305 3927DNAArtificial Sequenceengineered
3atggctatcc tagaccttaa gtccctcgtg ctgaacgcca ttaactactg gggccctaag
60aacaacaacg gcatccaggg cggtgacttc ggctacccca tctctgagaa gcagatcgac
120actagcatca ttaccttcac ccaccctcgc ttgatcccct acgatcttac
tatcccgcag 180aaccttgaga ccatcttcac cacaacgcag gtgctcacca
ataacactga cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc
actaccacga cctcaactag cacgaccaac 300ggttggacag aaggaggcaa
gatcagcgac acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg
gtgcgggtgg cgggaagaac tcgactacca tagaggccaa cttcgcacac
420aactctagca ccactacctt ccagcaagca agcactgaca ttgagtggaa
cattagccaa 480ccggtgctgg ttcctccctc taaacaagtt gtcgcgaccc
ttgtgatcat gggaggcaac 540tttaccatcc ctatggactt gatgaccacg
attgatagta cagagcacta ctcccactac 600tccggttacc ctatcctcac
ctggatctcg tccccagata actcttactc cggtcccttt 660atgtcatggt
actttgcaaa ctggcctaac cttccgagtg gattcggccc actgaatagt
720gataacacgg tcacatacac tggctctgtc gtgtcccaag tttcggccgg
tgtctacgct 780accgtccggt tcgatcagta tgacattcac aatctccgta
ctatcgagaa gacttggtat 840gctcgccatg cgacgctgca taatggcaag
aagatttcta tcaacaatgt cacggaaatg 900gctccaacat cccctatcaa gacaaat
9274309PRTArtificial Sequenceengineered 4Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Ala Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys
Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300
Pro Ile Lys Thr Asn 305 5927DNAArtificial Sequenceengineered
5atggctatcc tagaccttaa gtccctcgtg ctgaacgcca ttaactactg gggccctaag
60aacaacaacg gcatccaggg cggtgacttc ggctacccca tctctgagaa gcagatcgac
120actagcatca ttaccttcac ccaccctcgc ttgatcccct acgatcttac
tatcccgcag 180aaccttgaga ccatcttcac cacaacgcag gtgctcacca
ataacactga cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc
actaccacga cctcaactag cacgaccaac 300ggttggacag aaggaggcaa
gatcagcgac acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg
gtgagggtgg cgggaagaac tcgactacca tagaggccaa cttcgcacac
420aactctagca ccactaccgc ccagcaagca agcactgaca ttgagtggaa
cattagccaa 480ccggtgctgg ttcctccctc taaacaagtt gtcgcgaccc
ttgtgatcat gggaggcaac 540tttaccatcc ctatggactt gatgaccacg
attgatagta cagagcacta ctcccactac 600tccggttacc ctatcctcac
ctggatctcg tccccagata actcttactc cggtcccttt 660atgtcatggt
actttgcaaa ctggcctaac cttccgagtg gattcggccc actgaatagt
720gataacacgg tcacatacac tggctctgtc gtgtcccaag tttcggccgg
tgtctacgct 780accgtccggt tcgatcagta tgacattcac aatctccgta
ctatcgagaa gacttggtat 840gctcgccatg cgacgctgca taatggcaag
aagatttcta tcaacaatgt cacggaaatg 900gctccaacat cccctatcaa gacaaat
9276309PRTArtificial Sequenceengineered 6Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys
Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300
Pro Ile Lys Thr Asn 305 7918DNAArtificial Sequenceengineered
7atggctatcc tagaccttaa gtccctcgtg ctgaacgcca ttaactactg gggccctaag
60aacaacaacg gcatccaggg cggtgacttc ggctacccca tctctgagaa gcagatcgac
120actagcatca ttacctccac ccaccctcgc ttgatccccc acgatcttac
tatcccgcag 180aaccttgaga ccatcttcac cacaacgcag gtgctcacca
ataacactga cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc
actaccacga cctcaactag cacgaccaac 300ggttggacag aaggaggcaa
gatcagcgac acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg
gtgagggtgg cgggaagaac tcgactacca tagaggccaa cttcgcacac
420aactctagca ccactacctt ccagcaagca agcactgaca ttgagtggaa
cattagccaa 480ccggtccttg tgcctccccg caaacaggtt gttgccactc
tcgttatcat gggtggcaac 540ttcactattc ctatggatct tatgactacc
attgactcta ctgagcacta ctctggctac 600cccattctca cttggatctc
ttctcctgac aatagctaca acggtccatt catgtcatgg 660tacttcgcta
actggccgaa tctcccttct ggctttggtc ctcttaactc tgataacact
720gtgacctaca ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc
aactgttcgc 780ttcgatcagt atgacatcca taatctcagg actattgaga
agacctggta cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc
atcaataacg tgacagaaat ggcccctacc 900agcccgatca agactaac
9188306PRTArtificial Sequenceengineered 8Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 9918DNAArtificial Sequenceengineered 9atggctatcc
tagaccttaa gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg
gcatccaggg cggtgacttc ggctacccca tctctgagaa gcagatcgac
120actagcatca ttacctccac ccaccctcgc ttgatccccc acgatcttac
tatcccgcag 180aaccttgaga ccatcttcac cacaacgcag gtgctcacca
ataacactga cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc
actaccgcga cctcaactag cacgaccaac 300ggttggacag aaggaggcaa
gatcagcgac acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg
gtgagggtgg cgggaagaac tcgactacca tagaggccaa cttcgcacac
420aactctagca ccactacctt ccagcaagca agcactgaca ttgagtggaa
cattagccaa 480ccggtccttg tgcctccccg caaacaggtt gttgccactc
tcgttatcat gggtggcaac 540ttcactattc ctatggatct tatgactacc
attgactcta ctgagcacta ctctggctac 600cccattctca cttggatctc
ttctcctgac aatagctaca acggtccatt catgtcatgg 660tacttcgcta
actggccgaa tctcccttct ggctttggtc ctcttaactc tgataacact
720gtgacctaca ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc
aactgttcgc 780ttcgatcagt atgacatcca taatctcagg actattgaga
agacctggta cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc
atcaataacg tgacagaaat ggcccctacc 900agcccgatca agactaac
91810306PRTArtificial Sequenceengineered 10Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 11918DNAArtificial
Sequenceengineered 11atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91812306PRTArtificial Sequenceengineered
12Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 13918DNAArtificial
Sequenceengineered 13atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91814306PRTArtificial Sequenceengineered
14Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 15918DNAArtificial
Sequenceengineered 15atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91816306PRTArtificial Sequenceengineered
16Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 17918DNAArtificial
Sequenceengineered 17atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccgcga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91818306PRTArtificial Sequenceengineered
18Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 19918DNAArtificial
Sequenceengineered 19atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccaggaggca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91820306PRTArtificial Sequenceengineered
20Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Phe Gln Glu Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225
230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly
Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn
Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr
Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu
Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
21918DNAArtificial Sequenceengineered 21atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccgcga
cctcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactacctt ccaggcagca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca acggtccatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctcagg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaac 91822306PRTArtificial
Sequenceengineered 22Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Ala Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
23918DNAArtificial Sequenceengineered 23atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccgcga
cctcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactacctt ccaggaggca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca acggtccatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctcagg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaac 91824306PRTArtificial
Sequenceengineered 24Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Glu Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
25918DNAArtificial Sequenceengineered 25atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccacga
ccgcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactaccgc ccagcaagca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca gcggtccatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctcagg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaac 91826306PRTArtificial
Sequenceengineered 26Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
27918DNAArtificial Sequenceengineered 27atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccacga
ccgcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactaccgc ccagcaagca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca gcggtcgatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggctctgt cgtcagtcag gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctcagg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaac 91828306PRTArtificial
Sequenceengineered 28Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Ser Gly Arg Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
29918DNAArtificial Sequenceengineered 29atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccacga
ccgcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactaccgc ccagcaagca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca gcggtcgatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggctctgt cgccagtcag gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctcagg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaac 91830306PRTArtificial
Sequenceengineered 30Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Ser Gly
Arg Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Ala Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 31918DNAArtificial
Sequenceengineered 31atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctctgg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91832306PRTArtificial Sequenceengineered
32Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Ser Gly
Arg Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Trp Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 33918DNAArtificial
Sequenceengineered 33atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctc ccaggaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctctgg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91834306PRTArtificial Sequenceengineered
34Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ser Gln Glu Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Ser Gly
Arg Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Trp Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 35918DNAArtificial
Sequenceengineered 35atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttgcctc tgataacact 720gtgacctaca ctggctctgt cgccagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaac 91836306PRTArtificial Sequenceengineered
36Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Ser Gly
Arg Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Ala Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Ala Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 37306PRTArtificial
Sequenceengineered 37Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro
Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ser
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
38306PRTArtificial Sequenceengineered 38Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Val Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 39306PRTArtificial Sequenceengineered 39Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu Phe Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 40306PRTArtificial Sequenceengineered 40Met Ala Ile Leu
Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly
Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30
Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35
40 45 Pro Arg Leu Met Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu
Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp
Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr
Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly
Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser
Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr
Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe
Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160
Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165
170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile
Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp
Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser
Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly
Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser
Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg
Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys
Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285
Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290
295 300 Thr Asn 305 41306PRTArtificial Sequenceengineered 41Met Ala
Ile Leu Asp Leu Lys Ser Leu Val Leu Asp Ala Ile Asn Tyr 1 5 10 15
Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20
25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr
His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn
Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn
Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys
Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr
Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser
Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser
Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr
Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150
155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val
Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr
Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu
Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe
Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly
Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr
Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr
Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270
Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275
280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile
Lys 290 295 300 Thr Asn 305 42306PRTArtificial Sequenceengineered
42Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1
5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly
Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr
Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro
Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr
Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala
Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly
Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asp Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 43306PRTArtificial
Sequenceengineered 43Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
44306PRTArtificial Sequenceengineered 44Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Arg Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 45306PRTArtificial Sequenceengineered 45Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Thr Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 46306PRTArtificial Sequenceengineered 46Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Lys Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305
47306PRTArtificial Sequenceengineered 47Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Ile Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 48306PRTArtificial Sequenceengineered 48Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Ile Thr Tyr Lys Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 49306PRTArtificial Sequenceengineered 49Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Tyr Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 50306PRTArtificial Sequenceengineered 50Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Phe
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 51306PRTArtificial
Sequenceengineered 51Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Ala 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
52306PRTArtificial Sequenceengineered 52Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 53306PRTArtificial Sequenceengineered 53Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ala Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 54306PRTArtificial Sequenceengineered 54Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys
Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys
Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135
140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln
145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr
Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu
Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro
Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly
Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro
Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr
Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255
Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260
265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu Ala Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 55306PRTArtificial
Sequenceengineered 55Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Ala Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
56306PRTArtificial Sequenceengineered 56Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Ala His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 57306PRTArtificial Sequenceengineered 57Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Ala Asn 305 58306PRTArtificial Sequenceengineered 58Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Ala Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 59306PRTArtificial Sequenceengineered 59Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Ala Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 60306PRTArtificial
Sequenceengineered 60Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Ala Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
61306PRTArtificial Sequenceengineered 61Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225
230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly
Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn
Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr
Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu
Met Ala Pro Thr Ser Ala Ile Lys 290 295 300 Thr Asn 305
62306PRTArtificial Sequenceengineered 62Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ala Lys 290 295 300 Thr
Asn 305 63306PRTArtificial Sequenceengineered 63Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Ala His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 64306PRTArtificial Sequenceengineered 64Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Ala Asn 305 65306PRTArtificial Sequenceengineered 65Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 66306PRTArtificial
Sequenceengineered 66Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu Ala Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
67306PRTArtificial Sequenceengineered 67Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 68306PRTArtificial Sequenceengineered 68Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ala 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 69306PRTArtificial Sequenceengineered 69Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr
His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Ala Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 70306PRTArtificial Sequenceengineered 70Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Ala Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 71306PRTArtificial
Sequenceengineered 71Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ala Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
72306PRTArtificial Sequenceengineered 72Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 73306PRTArtificial Sequenceengineered 73Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Ala Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 74306PRTArtificial Sequenceengineered 74Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Ala Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 75306PRTArtificial Sequenceengineered 75Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Ala Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 76306PRTArtificial
Sequenceengineered 76Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ala Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 77306PRTArtificial Sequenceengineered 77Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Ala Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 78306PRTArtificial
Sequenceengineered 78Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ala Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
79306PRTArtificial Sequenceengineered 79Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Ala Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 80306PRTArtificial Sequenceengineered 80Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Ala
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 81306PRTArtificial Sequenceengineered 81Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Ala Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 82306PRTArtificial Sequenceengineered 82Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 83306PRTArtificial
Sequenceengineered 83Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Ala Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys
Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser
Pro Ile Lys 290 295 300 Thr Asn 305 84306PRTArtificial
Sequenceengineered 84Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Ala Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
85306PRTArtificial Sequenceengineered 85Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Ala Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 86306PRTArtificial Sequenceengineered 86Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ala
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 87306PRTArtificial Sequenceengineered 87Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Ala Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 88306PRTArtificial Sequenceengineered 88Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ala Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 89306PRTArtificial
Sequenceengineered 89Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Ala Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
90306PRTArtificial Sequenceengineered 90Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ser Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 91306PRTArtificial Sequenceengineered 91Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr
Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ala Val
Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 92306PRTArtificial Sequenceengineered 92Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ala 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 93306PRTArtificial Sequenceengineered 93Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ser His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 94306PRTArtificial
Sequenceengineered 94Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Ala Ile Lys 290 295 300 Thr Asn 305
95306PRTArtificial Sequenceengineered 95Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ala Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 96306PRTArtificial Sequenceengineered 96Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile
Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp
Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro
Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val
Val Ala Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295
300 Thr Asn 305 97306PRTArtificial Sequenceengineered 97Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 98306PRTArtificial Sequenceengineered 98Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200
205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn
210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp
Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Ala Val Ser Gln Val
Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp
Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg
His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn
Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
99306PRTArtificial Sequenceengineered 99Met Ala Ile Leu Asp Leu Lys
Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn
Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser
Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro
Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55
60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln
65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr
Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile
Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe
Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Ala 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 100306PRTArtificial Sequenceengineered 100Met Ala Ile Leu
Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly
Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30
Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35
40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu
Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp
Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr
Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly
Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser
Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr
Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala
Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160
Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165
170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile
Asp 180 185 190 Ser Thr Glu His Ala Ser Gly Tyr Pro Ile Leu Thr Trp
Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser
Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly
Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser
Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg
Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys
Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285
Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290
295 300 Thr Asn 305 101306PRTArtificial Sequenceengineered 101Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Ala Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 102306PRTArtificial
Sequenceengineered 102Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
103306PRTArtificial Sequenceengineered 103Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Ala Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 104306PRTArtificial Sequenceengineered 104Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Ala His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 105306PRTArtificial Sequenceengineered
105Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ala Lys 290 295 300 Thr Asn 305 106306PRTArtificial
Sequenceengineered 106Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ala Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 107306PRTArtificial
Sequenceengineered 107Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ser Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
108306PRTArtificial Sequenceengineered 108Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ala Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 109306PRTArtificial Sequenceengineered 109Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Ala Ser Pro Ile Lys
290 295 300 Thr Asn 305 110306PRTArtificial Sequenceengineered
110Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Ala Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 111306PRTArtificial
Sequenceengineered 111Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Ala Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
112306PRTArtificial Sequenceengineered 112Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Ala Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 113306PRTArtificial Sequenceengineered 113Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala
Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser
195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe
Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn
Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser
Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln
Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr
Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile
Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr
Asn 305 114306PRTArtificial Sequenceengineered 114Met Ala Ile Leu
Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly
Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30
Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35
40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu
Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp
Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr
Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly
Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser
Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr
Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala
Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160
Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165
170 175 Ala Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile
Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp
Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser
Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly
Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser
Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg
Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys
Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285
Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290
295 300 Thr Asn 305 115306PRTArtificial Sequenceengineered 115Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 116306PRTArtificial
Sequenceengineered 116Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Ala Ile Lys 290 295 300 Thr Asn 305
117306PRTArtificial Sequenceengineered 117Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu Ala Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 118306PRTArtificial Sequenceengineered 118Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ser His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 119306PRTArtificial Sequenceengineered
119Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Ala Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 120306PRTArtificial
Sequenceengineered 120Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Ala Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245
250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr
Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn
Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro
Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305 121306PRTArtificial
Sequenceengineered 121Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ala Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
122306PRTArtificial Sequenceengineered 122Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ala 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 123306PRTArtificial Sequenceengineered 123Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu Ala Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 124306PRTArtificial Sequenceengineered
124Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Ala Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 125306PRTArtificial
Sequenceengineered 125Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
126306PRTArtificial Sequenceengineered 126Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ala Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 127306PRTArtificial Sequenceengineered 127Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 128306PRTArtificial Sequenceengineered
128Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Ala Ser Pro Ile Lys 290 295 300
Thr Asn 305 129306PRTArtificial Sequenceengineered 129Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ser Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 130306PRTArtificial Sequenceengineered
130Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Ala Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 131306PRTArtificial
Sequenceengineered 131Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Ala Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
132306PRTArtificial Sequenceengineered 132Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Ala Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 133306PRTArtificial Sequenceengineered 133Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Ala Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 134306PRTArtificial Sequenceengineered
134Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Ala 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 135306PRTArtificial
Sequenceengineered 135Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn
Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr
Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205
Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210
215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn
Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser
Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile
His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His
Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val
Thr Glu Met Ala Pro Thr Ser Pro Ala Lys 290 295 300 Thr Asn 305
136306PRTArtificial Sequenceengineered 136Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ala Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 137306PRTArtificial Sequenceengineered 137Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ala Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 138306PRTArtificial Sequenceengineered
138Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Ala Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 139306PRTArtificial
Sequenceengineered 139Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Ala Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
140306PRTArtificial Sequenceengineered 140Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Ala Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 141306PRTArtificial Sequenceengineered 141Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Ala Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 142306PRTArtificial Sequenceengineered
142Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Ala Ile Lys 290
295 300 Thr Asn 305 143306PRTArtificial Sequenceengineered 143Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Ala Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 144306PRTArtificial
Sequenceengineered 144Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
Ala Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
145306PRTArtificial Sequenceengineered 145Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Ala Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 146306PRTArtificial Sequenceengineered 146Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Ala Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 147306PRTArtificial Sequenceengineered
147Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ala Lys 290 295 300 Thr Asn 305 148306PRTArtificial
Sequenceengineered 148Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
Ala Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
149306PRTArtificial Sequenceengineered 149Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Ala
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 150306PRTArtificial Sequenceengineered 150Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ala Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
151306PRTArtificial Sequenceengineered 151Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ser Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 152306PRTArtificial Sequenceengineered 152Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ala Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 153306PRTArtificial Sequenceengineered
153Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ala Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 154306PRTArtificial
Sequenceengineered 154Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ala Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
155306PRTArtificial Sequenceengineered 155Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Ala Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 156306PRTArtificial Sequenceengineered 156Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Ala Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 157306PRTArtificial Sequenceengineered
157Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220
Trp Pro Asn Leu Pro Ser Gly Ala Gly Pro Leu Asn Ser Asp Asn Thr 225
230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly
Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn
Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr
Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu
Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
158306PRTArtificial Sequenceengineered 158Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ala Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 159306PRTArtificial Sequenceengineered 159Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Ala Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 160306PRTArtificial Sequenceengineered
160Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Ala Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 161306PRTArtificial
Sequenceengineered 161Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Ala Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
162306PRTArtificial Sequenceengineered 162Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Ala Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 163306PRTArtificial Sequenceengineered 163Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Ala Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 164306PRTArtificial Sequenceengineered
164Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Ala Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn
Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250
255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile
260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly
Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser Pro Ile Lys 290 295 300 Thr Asn 305 165306PRTArtificial
Sequenceengineered 165Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30
Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35
40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu
Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp
Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr
Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly
Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser
Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr
Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe
Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160
Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165
170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile
Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp
Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser
Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly
Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser
Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg
Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys
Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285
Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Ala Ser Pro Ile Lys 290
295 300 Thr Asn 305 166306PRTArtificial Sequenceengineered 166Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Ala Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 167306PRTArtificial
Sequenceengineered 167Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Ala Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
168306PRTArtificial Sequenceengineered 168Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45
Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Ala
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ala Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser
Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr
Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu
Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val
Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp
Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp
Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser
Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300
Thr Asn 305 169306PRTArtificial Sequenceengineered 169Met Ala Ile
Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp
Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25
30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His
35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln Asn Leu
Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr
Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr
Thr Thr Ala Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu
Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val
Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr
Xaa Ile Xaa Ala Xaa Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr
Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155
160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile
165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr
Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Asn Gly Pro Phe Met
Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Arg Thr Ile 260 265 270 Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys 275 280
285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Lys
290 295 300 Thr Asn 305 170309PRTArtificial Sequenceengineered
170Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Xaa Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ser Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser His Tyr
Ser Gly Tyr Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn
Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp
Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp
Asn Thr Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250
255 Gly Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu
260 265 270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu
His Asn 275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met
Ala Pro Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305
171309PRTArtificial Sequenceengineered 171Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Xaa Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys
Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300
Pro Ile Lys Thr Asn 305 172309PRTArtificial Sequenceengineered
172Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Xaa Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala
Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu
Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met
Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185
190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp
195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met Ser
Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe Gly
Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly Ser
Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val Arg
Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu Lys
Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys Lys
Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300 Pro
Ile Lys Thr Asn 305 173309PRTArtificial Sequenceengineered 173Met
Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10
15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe
Thr His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Xaa Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly
Tyr Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr
Ser Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn
Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr
Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly
Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265
270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn
275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro
Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305 174309PRTArtificial
Sequenceengineered 174Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro
Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Xaa Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ser
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp 195 200 205 Ile
Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr 210 215
220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser
225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly Ser Val Val Ser Gln
Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr
Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala
Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys Lys Ile Ser Ile Asn
Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300 Pro Ile Lys Thr Asn
305 175309PRTArtificial Sequenceengineered 175Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro
Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40
45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly
Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile
Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Xaa Gln
Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp
180 185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu
Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe
Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly
Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr
Gly Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr
Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile
Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly
Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295
300 Pro Ile Lys Thr Asn 305 176309PRTArtificial Sequenceengineered
176Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Xaa Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ser Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser His Tyr
Ser Gly Tyr Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn
Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp
Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp
Asn Thr Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250
255 Gly Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu
260 265 270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu
His Asn 275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met
Ala Pro Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305
177309PRTArtificial Sequenceengineered 177Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Xaa Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Arg Thr Ile Glu
Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275 280 285 Gly Lys
Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser 290 295 300
Pro Ile Lys Thr Asn 305 178309PRTArtificial Sequenceengineered
178Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr
1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe
Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile
Thr Phe Thr His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile
Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu
Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe
Ala Lys Lys Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn
Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu
Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125
Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130
135 140 Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Xaa Trp Asn Ile Ser
Gln 145 150 155 160 Pro Val Leu Val Pro Pro Ser Lys Gln Val Val Ala
Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp
Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser His Tyr
Ser Gly Tyr Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn
Ser Tyr Ser Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp
Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp
Asn Thr Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250
255 Gly Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu
260 265 270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu
His Asn 275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met
Ala Pro Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305
179309PRTArtificial Sequenceengineered 179Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr His 35 40 45
Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr
Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro
Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu
Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Phe Gln Gln
Ala Ser Thr Asp Ile Glu Trp Xaa Ile Ser Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175
Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr Pro Ile Leu Thr
Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser Gly Pro Phe Met
Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Phe
Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val Thr Tyr Thr Gly
Ser Val Val Ser Gln Val Ser Ala 245
250 255 Gly Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn
Leu 260 265 270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr
Leu His Asn 275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu
Met Ala Pro Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305
180309PRTArtificial Sequenceengineered 180Met Ala Ile Leu Asp Leu
Lys Ser Leu Val Leu Xaa Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys
Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile
Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Xaa Thr His 35 40 45
Pro Arg Leu Xaa Pro Xaa Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50
55 60 Ile Phe Thr Xaa Thr Xaa Val Leu Thr Asn Asn Thr Asp Leu Gln
Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Xaa Lys Lys Thr Thr Thr Xaa
Thr Xaa Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr Glu Xaa Gly Lys
Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Xaa Val Xaa Ile Pro
Phe Ile Gly Xaa Gly Gly Xaa 115 120 125 Lys Asn Ser Thr Xaa Xaa Xaa
Ala Xaa Xaa Xaa His Asn Ser Ser Thr 130 135 140 Xaa Thr Xaa Xaa Xaa
Xaa Xaa Thr Xaa Ile Xaa Trp Xaa Xaa Xaa Gln 145 150 155 160 Pro Val
Leu Val Pro Pro Xaa Lys Gln Val Val Ala Thr Leu Xaa Ile 165 170 175
Xaa Gly Gly Xaa Phe Xaa Ile Pro Met Asp Xaa Met Thr Thr Ile Asp 180
185 190 Ser Thr Glu Xaa Xaa Xaa Xaa Xaa Xaa Gly Tyr Pro Ile Leu Thr
Xaa 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Xaa Gly Xaa Phe Met
Ser Xaa Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu Pro Ser Gly Xaa
Gly Pro Leu Xaa Ser 225 230 235 240 Xaa Asn Xaa Xaa Xaa Xaa Xaa Gly
Xaa Xaa Xaa Xaa Gln Val Ser Ala 245 250 255 Gly Val Tyr Ala Thr Val
Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270 Xaa Xaa Xaa Glu
Lys Thr Trp Tyr Ala Xaa His Ala Thr Leu Xaa Asn 275 280 285 Gly Lys
Lys Ile Xaa Ile Xaa Asn Val Thr Xaa Xaa Ala Pro Xaa Ser 290 295 300
Xaa Xaa Lys Xaa Asn 305 181927DNABacillus
thuringiensismisc_featureis a sequence representing a recombinant
polynucleotide derived from a native gene from a Bacillus
thuringiensis (Bt) species encoding a Cry51Aa1 protein
181atgatttttt tggcaatttt agatttaaaa tctttagtac tcaatgcaat
aaattattgg 60ggtcctaaaa ataataatgg catacagggt ggtgattttg gttaccctat
atcagaaaaa 120caaatagata cgtctattat aacttctact catcctcgtt
taattccaca tgatttaaca 180attcctcaaa atttagaaac tatttttact
acaactcaag tattaacaaa taatacagat 240ttacaacaaa gtcaaactgt
ttcttttgct aaaaaaacaa cgacaacaac ttcaacttca 300actacaaatg
gttggacaga aggtgggaaa atttcagata cattagaaga aaaagtaagt
360gtatctattc cttttattgg agagggagga ggaaaaaaca gtacaactat
agaagctaat 420tttgcacata actctagtac tactactttt caacaggctt
caactgatat agagtggaat 480atttcacaac cagtattggt tcccccacgt
aaacaagttg tagcaacatt agttattatg 540ggaggtaatt ttactattcc
tatggatttg atgactacta tagattctac agaacattat 600agtggttatc
caatattaac atggatatcg agccccgata atagttataa tggtccattt
660atgagttggt attttgcaaa ttggcccaat ttaccatcgg ggtttggtcc
tttaaattca 720gataatacgg tcacttatac aggttctgtt gtaagtcaag
tatcagctgg tgtatatgcc 780actgtacgat ttgatcaata tgatatacac
aatttaagga caattgaaaa aacttggtat 840gcacgacatg caactcttca
taatggaaag aaaatatcta taaataatgt tactgaaatg 900gcaccaacaa
gtccaataaa aacaaat 927182309PRTArtificial Sequenceengineered 182Met
Ile Phe Leu Ala Ile Leu Asp Leu Lys Ser Leu Val Leu Asn Ala 1 5 10
15 Ile Asn Tyr Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp
20 25 30 Phe Gly Tyr Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile
Ile Thr 35 40 45 Ser Thr His Pro Arg Leu Ile Pro His Asp Leu Thr
Ile Pro Gln Asn 50 55 60 Leu Glu Thr Ile Phe Thr Thr Thr Gln Val
Leu Thr Asn Asn Thr Asp 65 70 75 80 Leu Gln Gln Ser Gln Thr Val Ser
Phe Ala Lys Lys Thr Thr Thr Thr 85 90 95 Thr Ser Thr Ser Thr Thr
Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser 100 105 110 Asp Thr Leu Glu
Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu 115 120 125 Gly Gly
Gly Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn 130 135 140
Ser Ser Thr Thr Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn 145
150 155 160 Ile Ser Gln Pro Val Leu Val Pro Pro Arg Lys Gln Val Val
Ala Thr 165 170 175 Leu Val Ile Met Gly Gly Asn Phe Thr Ile Pro Met
Asp Leu Met Thr 180 185 190 Thr Ile Asp Ser Thr Glu His Tyr Ser Gly
Tyr Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr
Asn Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn
Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr
Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly
Val Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265
270 Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn
275 280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro
Thr Ser 290 295 300 Pro Ile Lys Thr Asn 305 183918DNABacillus
thuringiensismisc_featureis a sequence representing a recombinant
polynucleotide derived from a native gene from a Bacillus
thuringiensis (Bt) species encoding a TIC853 protein 183ttggcaattt
tagatttaaa atctttagta ctcgatgcaa taaactattg gggtcctaaa 60aataataatg
gtatacaggg ttataatttt aattacccta tatcagaaag acaaatagat
120acgtcgatta taacttctac tcattctcgt ttaatgccac atgatttaac
aattcctcaa 180aatttagaaa ctatttttac tacaactcaa gtattaacaa
ataatacaga tgtacaacaa 240agtcaaactg tttctttttc taaaaaaaca
acgacaacaa cttcaacttc aactacagat 300ggttggacag aaggtgggag
aatttcagat acattagaag aaaacgtaag tgtatctatt 360ccttttattg
gagcgggagg agcaaaaaac agtacaacta tagaagctaa tgttgcacat
420aactctagta ctactacttc tcaacaggct tcaactgaga tagagtggaa
tatttcacaa 480ccagtattgg ttcccccacg taaacaagtt gtagcaacat
tagttattat gggaggtgat 540tttactgttc ctatggattt gataactact
atagattcta cacaacattt tactggttat 600ccaatattaa catggataga
gaaccccgag cataatgtta gaggtcgatt tctgagttgg 660ttttttgcaa
attggcccaa tttaccatcg gagtttggtt ctttaaattc agataatacg
720atcacttata aaggttctgt tgtaagtcga atatcagctg gtgtatatgc
tactgtacga 780tttgatcaat atgctataaa taatttaaga acaattgaaa
aaacttggta tgcacgacat 840ggaactcttc ataatggaaa gaaaatatct
ataaataatg ttactgaaat ggcaccaaca 900agtccaatag aaagaaat
918184306PRTArtificial Sequenceengineered 184Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asp Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Tyr Asn Phe Asn Tyr 20 25 30 Pro
Ile Ser Glu Arg Gln Ile Asp Thr Ser Ile Ile Thr Ser Thr His 35 40
45 Ser Arg Leu Met Pro His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr
50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Val
Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ser Lys Lys Thr Thr Thr
Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asp Gly Trp Thr Glu Gly Gly
Arg Ile Ser Asp Thr Leu 100 105 110 Glu Glu Asn Val Ser Val Ser Ile
Pro Phe Ile Gly Ala Gly Gly Ala 115 120 125 Lys Asn Ser Thr Thr Ile
Glu Ala Asn Val Ala His Asn Ser Ser Thr 130 135 140 Thr Thr Ser Gln
Gln Ala Ser Thr Glu Ile Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro
Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu Val Ile 165 170
175 Met Gly Gly Asp Phe Thr Val Pro Met Asp Leu Ile Thr Thr Ile Asp
180 185 190 Ser Thr Gln His Phe Thr Gly Tyr Pro Ile Leu Thr Trp Ile
Glu Asn 195 200 205 Pro Glu His Asn Val Arg Gly Arg Phe Leu Ser Trp
Phe Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser Glu Phe Gly Ser
Leu Asn Ser Asp Asn Thr 225 230 235 240 Ile Thr Tyr Lys Gly Ser Val
Val Ser Arg Ile Ser Ala Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe
Asp Gln Tyr Ala Ile Asn Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr
Trp Tyr Ala Arg His Gly Thr Leu His Asn Gly Lys Lys 275 280 285 Ile
Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro Ile Glu 290 295
300 Arg Asn 305 185309PRTArtificial Sequenceengineered 185Met Ala
Ile Leu Asp Leu Lys Ser Leu Val Met Asn Ala Ile Asn Tyr 1 5 10 15
Trp Gly Pro Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr 20
25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Phe Thr
His 35 40 45 Pro Arg Leu Ile Pro Tyr Asp Leu Thr Ile Pro Gln Asn
Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn Asn
Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys Lys
Thr Thr Thr Thr Thr Ser Thr 85 90 95 Ser Thr Thr Asn Gly Trp Thr
Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val Ser
Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn Ser
Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140 Thr
Thr Phe Gln Gln Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145 150
155 160 Pro Val Leu Val Pro Pro Ser Lys Gln Val Val Ala Thr Leu Val
Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met Thr
Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser His Tyr Ser Gly Tyr
Pro Ile Leu Thr Trp 195 200 205 Ile Ser Ser Pro Asp Asn Ser Tyr Ser
Gly Pro Phe Met Ser Trp Tyr 210 215 220 Phe Ala Asn Trp Pro Asn Leu
Pro Ser Gly Phe Gly Pro Leu Asn Ser 225 230 235 240 Asp Asn Thr Val
Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala 245 250 255 Gly Val
Tyr Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu 260 265 270
Arg Thr Ile Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn 275
280 285 Gly Lys Lys Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr
Ser 290 295 300 Pro Ile Lys Thr Asn 305 186930DNAArtificial
Sequenceengineered 186atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttaccttcac ccaccctcgc
ttgatcccct acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgcgggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtgctgg ttcctccctc
taaacaagtt gtcgcgaccc ttgtgatcat gggaggcaac 540tttaccatcc
ctatggactt gatgaccacg attgatagta cagagcacta ctcccactac
600tccggttacc ctatcctcac ctggatctcg tccccagata actcttactc
cggtcccttt 660atgtcatggt actttgcaaa ctggcctaac cttccgagtg
gattcggccc actgaatagt 720gataacacgg tcacatacac tggctctgtc
gtgtcccaag tttcggccgg tgtctacgct 780accgtccggt tcgatcagta
tgacattcac aatctccgta ctatcgagaa gacttggtat 840gctcgccatg
cgacgctgca taatggcaag aagatttcta tcaacaatgt cacggaaatg
900gctccaacat cccctatcaa gacaaattga 930187930DNAArtificial
Sequenceengineered 187atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttaccttcac ccaccctcgc
ttgatcccct acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtgctgg ttcctccctc
taaacaagtt gtcgcgaccc ttgtgatcat gggaggcaac 540tttaccatcc
ctatggactt gatgaccacg attgatagta cagagcacta ctcccactac
600tccggttacc ctatcctcac ctggatctcg tccccagata actcttactc
cggtcccttt 660atgtcatggt actttgcaaa ctggcctaac cttccgagtg
gattcggccc actgaatagt 720gataacacgg tcacatacac tggctctgtc
gtgtcccaag tttcggccgg tgtctacgct 780accgtccggt tcgatcagta
tgacattcac aatctccgta ctatcgagaa gacttggtat 840gctcgccatg
cgacgctgca taatggcaag aagatttcta tcaacaatgt cacggaaatg
900gctccaacat cccctatcaa gacaaattga 930188921DNAArtificial
Sequenceengineered 188atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921189921DNAArtificial
Sequenceengineered 189atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccgcga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921190921DNAArtificial
Sequenceengineered 190atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac
ccaccctcgc ttgatccccc acgatcttac tatcccgcag 180aaccttgaga
ccatcttcac cacaacgcag gtgctcacca ataacactga cctccagcaa
240tcccagaccg tgagctttgc gaagaagacc actaccacga ccgcaactag
cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac acgctggagg
agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac
tcgactacca tagaggccaa cttcgcacac 420aactctagca ccactacctt
ccagcaagca agcactgaca ttgagtggaa cattagccaa 480ccggtccttg
tgcctccccg caaacaggtt gttgccactc tcgttatcat gggtggcaac
540ttcactattc ctatggatct tatgactacc attgactcta ctgagcacta
ctctggctac 600cccattctca cttggatctc ttctcctgac aatagctaca
acggtccatt catgtcatgg 660tacttcgcta actggccgaa tctcccttct
ggctttggtc ctcttaactc tgataacact 720gtgacctaca ctggctctgt
cgtcagtcag gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt
atgacatcca taatctcagg actattgaga agacctggta cgctcgtcat
840gcgacgcttc acaacggcaa gaagatcagc atcaataacg tgacagaaat
ggcccctacc 900agcccgatca agactaactg a 921191921DNAArtificial
Sequenceengineered 191atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921192921DNAArtificial
Sequenceengineered 192atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921193921DNAArtificial
Sequenceengineered 193atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccgcga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921194921DNAArtificial
Sequenceengineered 194atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccaggaggca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaacta g 921195921DNAArtificial
Sequenceengineered 195atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccgcga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccaggcagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921196921DNAArtificial
Sequenceengineered 196atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccgcga cctcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctt ccaggaggca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca acggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921197921DNAArtificial
Sequenceengineered 197atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtccatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921198921DNAArtificial
Sequenceengineered 198atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921199921DNAArtificial
Sequenceengineered 199atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgccagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctcagg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921200921DNAArtificial
Sequenceengineered 200atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactaccgc ccagcaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctctgg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921201921DNAArtificial
Sequenceengineered 201atggctatcc tagaccttaa gtccctcgtg ctgaacgcca
ttaactactg gggccctaag 60aacaacaacg gcatccaggg cggtgacttc ggctacccca
tctctgagaa gcagatcgac 120actagcatca ttacctccac ccaccctcgc
ttgatccccc acgatcttac tatcccgcag 180aaccttgaga ccatcttcac
cacaacgcag gtgctcacca ataacactga cctccagcaa 240tcccagaccg
tgagctttgc gaagaagacc actaccacga ccgcaactag cacgaccaac
300ggttggacag aaggaggcaa gatcagcgac acgctggagg agaaagtttc
ggttagcatt 360ccgttcatcg gtgagggtgg cgggaagaac tcgactacca
tagaggccaa cttcgcacac 420aactctagca ccactacctc ccaggaagca
agcactgaca ttgagtggaa cattagccaa 480ccggtccttg tgcctccccg
caaacaggtt gttgccactc tcgttatcat gggtggcaac 540ttcactattc
ctatggatct tatgactacc attgactcta ctgagcacta ctctggctac
600cccattctca cttggatctc ttctcctgac aatagctaca gcggtcgatt
catgtcatgg 660tacttcgcta actggccgaa tctcccttct ggctttggtc
ctcttaactc tgataacact 720gtgacctaca ctggctctgt cgtcagtcag
gtctctgccg gtgtgtacgc aactgttcgc 780ttcgatcagt atgacatcca
taatctctgg actattgaga agacctggta cgctcgtcat 840gcgacgcttc
acaacggcaa gaagatcagc atcaataacg tgacagaaat ggcccctacc
900agcccgatca agactaactg a 921202306PRTArtificial
Sequenceengineered 202Met Ala Ile Leu Asp Leu Lys Ser Leu Val Leu
Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro Lys Asn Asn Asn Gly Ile
Gln Gly Gly Asp Phe Gly Tyr 20 25 30 Pro Ile Ser Glu Lys Gln Ile
Asp Thr Ser Ile Ile Thr Ser Thr His 35 40 45 Pro Arg Leu Ile Pro
His Asp Leu Thr Ile Pro Gln Asn Leu Glu Thr 50 55 60 Ile Phe Thr
Thr Thr Gln Val Leu Thr Asn Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser
Gln Thr Val Ser Phe Ala Lys Lys Thr Thr Thr Thr Thr Ala Thr 85 90
95 Ser Thr Thr Asn Gly Trp Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu
100 105 110 Glu Glu Lys Val Ser Val Ser Ile Pro Phe Ile Gly Glu Gly
Gly Gly 115 120 125 Lys Asn Ser Thr Thr Ile Glu Ala Asn Phe Ala His
Asn Ser Ser Thr 130 135 140 Thr Thr Ala Gln Gln Ala Ser Thr Asp Ile
Glu Trp Asn Ile Ser Gln 145 150 155 160 Pro Val Leu Val Pro Pro Arg
Lys Gln Val Val Ala Thr Leu Val Ile 165 170 175 Met Gly Gly Asn Phe
Thr Ile Pro Met Asp Leu Met Thr Thr Ile Asp 180 185 190 Ser Thr Glu
His Tyr Ser Gly Tyr Pro Ile Leu Thr Trp Ile Ser Ser 195 200 205 Pro
Asp Asn Ser Tyr Asn Gly Pro Phe Met Ser Trp Tyr Phe Ala Asn 210 215
220 Trp Pro Asn Leu Pro Ser Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr
225 230 235 240 Val Thr Tyr Thr Gly Ser Val Val Ser Gln Val Ser Ala
Gly Val Tyr 245 250 255 Ala Thr Val Arg Phe Asp Gln Tyr Asp Ile His
Asn Leu Arg Thr Ile 260 265 270 Glu Lys Thr Trp Tyr Ala Arg His Ala
Thr Leu His Asn Gly Lys Lys 275 280 285 Ile Ser Ile Asn Asn Val Thr
Glu Met Ala Pro Thr Ser Pro Ile Lys 290 295 300 Thr Asn 305
203921DNAArtificial Sequenceengineered 203atggctatcc tagaccttaa
gtccctcgtg ctgaacgcca ttaactactg gggccctaag 60aacaacaacg gcatccaggg
cggtgacttc ggctacccca tctctgagaa gcagatcgac 120actagcatca
ttacctccac ccaccctcgc ttgatccccc acgatcttac tatcccgcag
180aaccttgaga ccatcttcac cacaacgcag gtgctcacca ataacactga
cctccagcaa 240tcccagaccg tgagctttgc gaagaagacc actaccacga
ccgcaactag cacgaccaac 300ggttggacag aaggaggcaa gatcagcgac
acgctggagg agaaagtttc ggttagcatt 360ccgttcatcg gtgagggtgg
cgggaagaac tcgactacca tagaggccaa cttcgcacac 420aactctagca
ccactacctc ccaggaagca agcactgaca ttgagtggaa cattagccaa
480ccggtccttg tgcctccccg caaacaggtt gttgccactc tcgttatcat
gggtggcaac 540ttcactattc ctatggatct tatgactacc attgactcta
ctgagcacta ctctggctac 600cccattctca cttggatctc ttctcctgac
aatagctaca gcggtcgatt catgtcatgg 660tacttcgcta actggccgaa
tctcccttct ggctttggtc ctcttaactc tgataacact 720gtgacctaca
ctggccgggt cgaaagtcgg gtctctgccg gtgtgtacgc aactgttcgc
780ttcgatcagt atgacatcca taatctctgg actattgaga agacctggta
cgctcgtcat 840gcgacgcttc acaacggcaa gaagatcagc atcaataacg
tgacagaaat ggcccctacc 900agcccgatca agactaactg a
921204306PRTArtificial sequenceengineered 204Met Ala Ile Leu Asp
Leu Lys Ser Leu Val Leu Asn Ala Ile Asn Tyr 1 5 10 15 Trp Gly Pro
Lys Asn Asn Asn Gly Ile Gln Gly Gly Asp Phe Gly Tyr
20 25 30 Pro Ile Ser Glu Lys Gln Ile Asp Thr Ser Ile Ile Thr Ser
Thr His 35 40 45 Pro Arg Leu Ile Pro His Asp Leu Thr Ile Pro Gln
Asn Leu Glu Thr 50 55 60 Ile Phe Thr Thr Thr Gln Val Leu Thr Asn
Asn Thr Asp Leu Gln Gln 65 70 75 80 Ser Gln Thr Val Ser Phe Ala Lys
Lys Thr Thr Thr Thr Thr Ala Thr 85 90 95 Ser Thr Thr Asn Gly Trp
Thr Glu Gly Gly Lys Ile Ser Asp Thr Leu 100 105 110 Glu Glu Lys Val
Ser Val Ser Ile Pro Phe Ile Gly Glu Gly Gly Gly 115 120 125 Lys Asn
Ser Thr Thr Ile Glu Ala Asn Phe Ala His Asn Ser Ser Thr 130 135 140
Thr Thr Ser Gln Glu Ala Ser Thr Asp Ile Glu Trp Asn Ile Ser Gln 145
150 155 160 Pro Val Leu Val Pro Pro Arg Lys Gln Val Val Ala Thr Leu
Val Ile 165 170 175 Met Gly Gly Asn Phe Thr Ile Pro Met Asp Leu Met
Thr Thr Ile Asp 180 185 190 Ser Thr Glu His Tyr Ser Gly Tyr Pro Ile
Leu Thr Trp Ile Ser Ser 195 200 205 Pro Asp Asn Ser Tyr Ser Gly Arg
Phe Met Ser Trp Tyr Phe Ala Asn 210 215 220 Trp Pro Asn Leu Pro Ser
Gly Phe Gly Pro Leu Asn Ser Asp Asn Thr 225 230 235 240 Val Thr Tyr
Thr Gly Arg Val Glu Ser Arg Val Ser Ala Gly Val Tyr 245 250 255 Ala
Thr Val Arg Phe Asp Gln Tyr Asp Ile His Asn Leu Trp Thr Ile 260 265
270 Glu Lys Thr Trp Tyr Ala Arg His Ala Thr Leu His Asn Gly Lys Lys
275 280 285 Ile Ser Ile Asn Asn Val Thr Glu Met Ala Pro Thr Ser Pro
Ile Lys 290 295 300 Thr Asn 305 2052577DNABacillus
thuringiensismisc_featureAXMI-171 US2010/0298207 A1 SEQ ID NO204
205atgaaaaata aaaagaaata tatgaagcca ctcgcagtag gcttgctcgc
aactaacatt 60attggatttg gtactcagac agtagcgttt gctgcgacag ataaagcggg
ttccaaagaa 120cagatgcagc aacaaatgaa aacacagaat aagagcttta
atccgacagt attagccagt 180atgccatcgg atacatcgga gcttcaaaaa
atgttggaag acgcgattaa aaataaggat 240acccagatta ctccggaatt
aataaaaaaa cttcaggaca aaggatttga ttaccttagt 300attgtaaagg
gtttaactgg cggattactg aagcaaattc cgtatgcagg ttcaatcctc
360tcccctttgg tagttggcct ttttccaggt aagggttatg taacgaaggc
gaatgtctgg 420ggagagatac aggatcgcgt ttcaaattta atagatcaaa
aattagaaga gtcacaagta 480aataacttaa ttgggaaact aacgggtatt
caggataatt taggaatata ccaaactcgg 540gttggtttag ttaatgggat
aaaaccacca attgctaatt ttatacaaaa ggatgcaaat 600tctgataaaa
ataaggagaa tttaagaagc acaatagact ccttggacaa ggatttaggc
660cgagtgatac ctgagtttgc tgttaaaggt tacgaggcag cttctcttcc
atattatgta 720caagttgcca atgtgcatct tttcttattg aaagatgcac
ttacacatgc agatgagtgg 780gggcttactg atgatgaaaa gagaggatat
ttgtcaagac ttcaacaaaa aattcaagag 840tatagcagcg tcgtatatga
ttcctttaat aaaggagtcg aagccgctaa aagtaagggt 900ggaagtaccg
ccgacagttg gaacagaacc aatgcctatg taagaacaat gacattgtat
960ggtttagatt ttgtggcttt atggccggct tttgatacta aacattataa
tcagccagta 1020aaattgcagc aaacacgtga attatattct aacatgatag
gaagaccaat aaactggcaa 1080gactatgata caactcttca acaaattcat
aatagtgggt atgcgggtta tccaggcgag 1140ctgaaacaag ttggtgtttc
acagtgggat cgtattgatg gaatcaggga aatatttgat 1200tggactggag
acggctcacg agattatacg ctacaatggg gccacgcaaa caaaaatggg
1260tattcggacc gtagccagac cgtcaataac ccagcaatag gaatttcagc
atatgaatcc 1320aataatgcta atttctataa tatgtctact atcacatata
aacaaaataa cgaagtatct 1380tggttctatg gtccatttac tactcaaagc
gatagtaaag atggaagtag aatagatagc 1440aaagctccag cgggccataa
attatctcgc gtcaaagtac aagaaaaaag atcagatcta 1500aatacaatat
catcttttgt ggctgcatat gttcctgaag aagttcatcc acagaatata
1560cttgaggcta aagctattac aggggtacca gctgaaaaat atctcgcaca
tgcaggattt 1620gaagataaga ttgaatacat gaatggttcg aatgcgatgg
tatcttctaa aaatggtgac 1680acgatagatt acaatgttca aagtccagga
aaacaaaaat ataaaatacg cctccgtgtt 1740gcgacaaata gtgacacatc
tgtgggaatc tctataaatg gggattctca gcaagtgaat 1800ataaaaaata
cagaagccgc aacaaagtta gaagacggta ttacagttaa aggtgtaaat
1860gggaagtaca tgttaattga cggaccaact gttgaactta gcgaaggtgt
gaatacaatt 1920cagcttaaaa atagtggtgg agctaagatt gcattagatc
gaatagaatt tgagcctata 1980ggcggtgagc tacgcaagtg gaaacaggaa
ggtgataagt ggtactttta cgatgaaaat 2040gataaaaagt taacaggttg
gcaaaagatt aatgaaagaa aatactacct tggacattct 2100ggtgatggtt
ctggtatgac cactgaaggg gagatggcaa caggctggaa aacgattgat
2160ggagtacaat attactttgg acattctggt gatggttctg gtatggtcac
tgaaggggag 2220atggcaacag gctggaaaac gataaatgga gtaaaatatt
attttggaca gactggtgat 2280ggctctggta tgcaacacga aggggaaaag
gcaacaggct ggaaaacgat tgatggagta 2340aaatattact tcaataaaac
tggtgatggc tctggtatgc aacacgaagg ggaaaaggca 2400ataggctgga
aaacgattga tggagtaaaa tattacttca ataaaactgg tgatggctct
2460ggtatgcaac acgaaggaga aatggcatta ggagatatga cgattgatgg
agtaaaacat 2520cactttaata aaactggtga tggaacgggt cgcgaccatg
aaggagagct cgtatgg 2577206859PRTBacillus
thuringiensismisc_featureAXMI-171 US2010/0298207 A1 SEQ ID NO205
206Met Lys Asn Lys Lys Lys Tyr Met Lys Pro Leu Ala Val Gly Leu Leu
1 5 10 15 Ala Thr Asn Ile Ile Gly Phe Gly Thr Gln Thr Val Ala Phe
Ala Ala 20 25 30 Thr Asp Lys Ala Gly Ser Lys Glu Gln Met Gln Gln
Gln Met Lys Thr 35 40 45 Gln Asn Lys Ser Phe Asn Pro Thr Val Leu
Ala Ser Met Pro Ser Asp 50 55 60 Thr Ser Glu Leu Gln Lys Met Leu
Glu Asp Ala Ile Lys Asn Lys Asp 65 70 75 80 Thr Gln Ile Thr Pro Glu
Leu Ile Lys Lys Leu Gln Asp Lys Gly Phe 85 90 95 Asp Tyr Leu Ser
Ile Val Lys Gly Leu Thr Gly Gly Leu Leu Lys Gln 100 105 110 Ile Pro
Tyr Ala Gly Ser Ile Leu Ser Pro Leu Val Val Gly Leu Phe 115 120 125
Pro Gly Lys Gly Tyr Val Thr Lys Ala Asn Val Trp Gly Glu Ile Gln 130
135 140 Asp Arg Val Ser Asn Leu Ile Asp Gln Lys Leu Glu Glu Ser Gln
Val 145 150 155 160 Asn Asn Leu Ile Gly Lys Leu Thr Gly Ile Gln Asp
Asn Leu Gly Ile 165 170 175 Tyr Gln Thr Arg Val Gly Leu Val Asn Gly
Ile Lys Pro Pro Ile Ala 180 185 190 Asn Phe Ile Gln Lys Asp Ala Asn
Ser Asp Lys Asn Lys Glu Asn Leu 195 200 205 Arg Ser Thr Ile Asp Ser
Leu Asp Lys Asp Leu Gly Arg Val Ile Pro 210 215 220 Glu Phe Ala Val
Lys Gly Tyr Glu Ala Ala Ser Leu Pro Tyr Tyr Val 225 230 235 240 Gln
Val Ala Asn Val His Leu Phe Leu Leu Lys Asp Ala Leu Thr His 245 250
255 Ala Asp Glu Trp Gly Leu Thr Asp Asp Glu Lys Arg Gly Tyr Leu Ser
260 265 270 Arg Leu Gln Gln Lys Ile Gln Glu Tyr Ser Ser Val Val Tyr
Asp Ser 275 280 285 Phe Asn Lys Gly Val Glu Ala Ala Lys Ser Lys Gly
Gly Ser Thr Ala 290 295 300 Asp Ser Trp Asn Arg Thr Asn Ala Tyr Val
Arg Thr Met Thr Leu Tyr 305 310 315 320 Gly Leu Asp Phe Val Ala Leu
Trp Pro Ala Phe Asp Thr Lys His Tyr 325 330 335 Asn Gln Pro Val Lys
Leu Gln Gln Thr Arg Glu Leu Tyr Ser Asn Met 340 345 350 Ile Gly Arg
Pro Ile Asn Trp Gln Asp Tyr Asp Thr Thr Leu Gln Gln 355 360 365 Ile
His Asn Ser Gly Tyr Ala Gly Tyr Pro Gly Glu Leu Lys Gln Val 370 375
380 Gly Val Ser Gln Trp Asp Arg Ile Asp Gly Ile Arg Glu Ile Phe Asp
385 390 395 400 Trp Thr Gly Asp Gly Ser Arg Asp Tyr Thr Leu Gln Trp
Gly His Ala 405 410 415 Asn Lys Asn Gly Tyr Ser Asp Arg Ser Gln Thr
Val Asn Asn Pro Ala 420 425 430 Ile Gly Ile Ser Ala Tyr Glu Ser Asn
Asn Ala Asn Phe Tyr Asn Met 435 440 445 Ser Thr Ile Thr Tyr Lys Gln
Asn Asn Glu Val Ser Trp Phe Tyr Gly 450 455 460 Pro Phe Thr Thr Gln
Ser Asp Ser Lys Asp Gly Ser Arg Ile Asp Ser 465 470 475 480 Lys Ala
Pro Ala Gly His Lys Leu Ser Arg Val Lys Val Gln Glu Lys 485 490 495
Arg Ser Asp Leu Asn Thr Ile Ser Ser Phe Val Ala Ala Tyr Val Pro 500
505 510 Glu Glu Val His Pro Gln Asn Ile Leu Glu Ala Lys Ala Ile Thr
Gly 515 520 525 Val Pro Ala Glu Lys Tyr Leu Ala His Ala Gly Phe Glu
Asp Lys Ile 530 535 540 Glu Tyr Met Asn Gly Ser Asn Ala Met Val Ser
Ser Lys Asn Gly Asp 545 550 555 560 Thr Ile Asp Tyr Asn Val Gln Ser
Pro Gly Lys Gln Lys Tyr Lys Ile 565 570 575 Arg Leu Arg Val Ala Thr
Asn Ser Asp Thr Ser Val Gly Ile Ser Ile 580 585 590 Asn Gly Asp Ser
Gln Gln Val Asn Ile Lys Asn Thr Glu Ala Ala Thr 595 600 605 Lys Leu
Glu Asp Gly Ile Thr Val Lys Gly Val Asn Gly Lys Tyr Met 610 615 620
Leu Ile Asp Gly Pro Thr Val Glu Leu Ser Glu Gly Val Asn Thr Ile 625
630 635 640 Gln Leu Lys Asn Ser Gly Gly Ala Lys Ile Ala Leu Asp Arg
Ile Glu 645 650 655 Phe Glu Pro Ile Gly Gly Glu Leu Arg Lys Trp Lys
Gln Glu Gly Asp 660 665 670 Lys Trp Tyr Phe Tyr Asp Glu Asn Asp Lys
Lys Leu Thr Gly Trp Gln 675 680 685 Lys Ile Asn Glu Arg Lys Tyr Tyr
Leu Gly His Ser Gly Asp Gly Ser 690 695 700 Gly Met Thr Thr Glu Gly
Glu Met Ala Thr Gly Trp Lys Thr Ile Asp 705 710 715 720 Gly Val Gln
Tyr Tyr Phe Gly His Ser Gly Asp Gly Ser Gly Met Val 725 730 735 Thr
Glu Gly Glu Met Ala Thr Gly Trp Lys Thr Ile Asn Gly Val Lys 740 745
750 Tyr Tyr Phe Gly Gln Thr Gly Asp Gly Ser Gly Met Gln His Glu Gly
755 760 765 Glu Lys Ala Thr Gly Trp Lys Thr Ile Asp Gly Val Lys Tyr
Tyr Phe 770 775 780 Asn Lys Thr Gly Asp Gly Ser Gly Met Gln His Glu
Gly Glu Lys Ala 785 790 795 800 Ile Gly Trp Lys Thr Ile Asp Gly Val
Lys Tyr Tyr Phe Asn Lys Thr 805 810 815 Gly Asp Gly Ser Gly Met Gln
His Glu Gly Glu Met Ala Leu Gly Asp 820 825 830 Met Thr Ile Asp Gly
Val Lys His His Phe Asn Lys Thr Gly Asp Gly 835 840 845 Thr Gly Arg
Asp His Glu Gly Glu Leu Val Trp 850 855
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