U.S. patent application number 13/809289 was filed with the patent office on 2013-08-22 for chimeric clotting factors. This patent application is currently assigned to Biogen Idec Hemophilia Inc.. The applicant listed for this patent is Alan Bitonti, Robert Peters, Joe Salas. Invention is credited to Alan Bitonti, Robert Peters, Joe Salas.
Application Number | 20130216513 13/809289 |
Document ID | / |
Family ID | 44629302 |
Filed Date | 2013-08-22 |
United States Patent Application | 20130216513 |
Kind Code | A1 |
Salas; Joe ; et al. | August 22, 2013 |
Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of coagulation), have reduced clearance rates, have improved manufacturability, have reduced thrombogenicity, have enhanced activity, or have more than one of these characteristics are described as are methods for making chimeric clotting factors and methods for improving hemostasia using these clotting factors.
Inventors: | Salas; Joe; (Wayland, MA) ; Peters; Robert; (West Roxbury, MA) ; Bitonti; Alan; (Acton, MA) | ||||||||||
Applicant: |
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Assignee: | Biogen Idec Hemophilia Inc. Waltham MA |
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Family ID: | 44629302 | ||||||||||
Appl. No.: | 13/809289 | ||||||||||
Filed: | July 11, 2011 | ||||||||||
PCT Filed: | July 11, 2011 | ||||||||||
PCT NO: | PCT/US2011/043597 | ||||||||||
371 Date: | May 6, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
61363183 | Jul 9, 2010 | |||
61363186 | Jul 9, 2010 | |||
61442055 | Feb 11, 2011 | |||
61442150 | Feb 11, 2011 | |||
61442029 | Feb 11, 2011 | |||
61467880 | Mar 25, 2011 | |||
61491762 | May 31, 2011 | |||
Current U.S. Class: | 424/94.3 ; 435/188; 435/252.3; 435/254.2; 435/320.1; 435/352; 435/354; 435/358; 435/365; 435/367; 435/369; 536/23.2 |
Current CPC Class: | C07K 14/745 20130101; C07K 2317/622 20130101; C07K 14/755 20130101; C07K 2319/33 20130101; A61K 2039/505 20130101; C12N 9/644 20130101; C07K 16/2848 20130101; C07K 2319/30 20130101; C12N 9/96 20130101; C12N 9/6437 20130101; A61K 38/00 20130101; C07K 2319/00 20130101; A61P 7/04 20180101; C12N 9/647 20130101; C12Y 304/21021 20130101; C12Y 304/21022 20130101; C07K 16/18 20130101; C07K 16/28 20130101; C12N 9/6432 20130101 |
Class at Publication: | 424/94.3 ; 536/23.2; 435/188; 435/320.1; 435/358; 435/367; 435/365; 435/352; 435/354; 435/369; 435/252.3; 435/254.2 |
International Class: | C12N 9/96 20060101 C12N009/96 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 159 <210> SEQ ID NO 1 <211> LENGTH: 50 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic peptide
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (6)..(50) <223> OTHER INFORMATION: Any grouping of
"Gly Gly Gly Gly Ser" may be present or absent <400>
SEQUENCE: 1 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 20 25 30 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser 50 <210> SEQ ID NO 2
<211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 2 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 30
<210> SEQ ID NO 3 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 3 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 1 5 10 15 Gly Gly Gly Ser 20 <210> SEQ ID NO 4
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 4 Thr Gln Ser
Phe Asn Asp Phe Thr Arg 1 5 <210> SEQ ID NO 5 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 5 Ser Val Ser Gln Thr Ser
Lys Leu Thr Arg 1 5 10 <210> SEQ ID NO 6 <211> LENGTH:
10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 6 Asp Phe Leu Ala Glu Gly Gly Gly Val
Arg 1 5 10 <210> SEQ ID NO 7 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 7 Thr Thr Lys Ile Lys Pro Arg 1 5
<210> SEQ ID NO 8 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 8 Ala Leu Arg Pro Arg Val Val Gly Gly Ala 1 5 10
<210> SEQ ID NO 9 <211> LENGTH: 4 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 9 Glu Leu Leu Gly 1 <210> SEQ ID NO 10 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 10 Pro Lys Asn Ser Ser Met
Ile Ser Asn Thr Pro 1 5 10 <210> SEQ ID NO 11 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 11 His Gln Ser Leu Gly Thr
Gln 1 5 <210> SEQ ID NO 12 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic peptide
<400> SEQUENCE: 12 His Gln Asn Leu Ser Asp Gly Lys 1 5
<210> SEQ ID NO 13 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 13 His Gln Asn Ile Ser Asp Gly Lys 1 5 <210> SEQ ID
NO 14 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 14 Val
Ile Ser Ser His Leu Gly Gln 1 5 <210> SEQ ID NO 15
<400> SEQUENCE: 15 000 <210> SEQ ID NO 16 <400>
SEQUENCE: 16 000 <210> SEQ ID NO 17 <400> SEQUENCE: 17
000 <210> SEQ ID NO 18 <400> SEQUENCE: 18 000
<210> SEQ ID NO 19 <400> SEQUENCE: 19 000 <210>
SEQ ID NO 20 <400> SEQUENCE: 20 000 <210> SEQ ID NO 21
<400> SEQUENCE: 21 000 <210> SEQ ID NO 22 <400>
SEQUENCE: 22 000 <210> SEQ ID NO 23 <400> SEQUENCE: 23
000 <210> SEQ ID NO 24 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic peptide
<400> SEQUENCE: 24 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 25 <211>
LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (2)..(31) <223> OTHER
INFORMATION: Any grouping of "Gly Gly Gly Gly Ser" may be present
or absent <400> SEQUENCE: 25 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 30 <210> SEQ ID NO
26 <400> SEQUENCE: 26 000 <210> SEQ ID NO 27
<400> SEQUENCE: 27 000 <210> SEQ ID NO 28 <400>
SEQUENCE: 28 000 <210> SEQ ID NO 29 <400> SEQUENCE: 29
000 <210> SEQ ID NO 30 <400> SEQUENCE: 30 000
<210> SEQ ID NO 31 <400> SEQUENCE: 31 000 <210>
SEQ ID NO 32 <400> SEQUENCE: 32 000 <210> SEQ ID NO 33
<400> SEQUENCE: 33 000 <210> SEQ ID NO 34 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 34 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser
Gly Gly Gly Ala Ser 20 25 <210> SEQ ID NO 35 <400>
SEQUENCE: 35 000 <210> SEQ ID NO 36 <211> LENGTH: 101
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 36 catcggatcc cccgccaccg gaacctccac
cgcctgatcc acccccacct gatccgccgc 60 caccgctccg gcggcgccgt
ttacccggag acagggagag g 101 <210> SEQ ID NO 37 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 37 Arg Arg Arg Arg Ser 1 5
<210> SEQ ID NO 38 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 38 Arg Lys Arg Arg Lys Arg 1 5 <210> SEQ ID NO 39
<211> LENGTH: 37 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 39 agtcaagctt
gtcgactccg gaactcctgg gcggacc 37 <210> SEQ ID NO 40
<211> LENGTH: 86 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 40 catcggatcc
cccgccaccg gaacctccac cgcctgatcc acccccacct gatccgccgc 60
cacctttacc cggagacagg gagagg 86 <210> SEQ ID NO 41
<211> LENGTH: 35 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 41 cagtcttgat
cagacaaaac tcacacatgc ccacc 35 <210> SEQ ID NO 42 <211>
LENGTH: 34 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 42 actgacgaat tctcatttac
ccggagacag ggag 34 <210> SEQ ID NO 43 <211> LENGTH: 40
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 43 cgacaagctt gccgccacca tggtctccca
ggccctcagg 40 <210> SEQ ID NO 44 <211> LENGTH: 156
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 44 aggagttccg gagctgggca cggtgggcat
gtgtgagttt tgtcggatcc cccgccaccg 60 gaacctccac cgcctgatcc
acccccacct gatccgccgc caccggaccc acctccgccg 120 gagccaccgc
caccgggaaa tggggctcgc aggagg 156 <210> SEQ ID NO 45
<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 45 Arg Arg Arg
Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25
30 Gly Gly Ser Arg Lys Arg Arg Lys Arg 35 40 <210> SEQ ID NO
46 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer <400> SEQUENCE: 46
gggaatgtca acaggcaggg 20 <210> SEQ ID NO 47 <211>
LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 47 cttggctttc tctccacagg c
21 <210> SEQ ID NO 48 <211> LENGTH: 62 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer
<400> SEQUENCE: 48 cgactccgga gctgggcacg gtgggcatgt
gtgagttttg tcgggaaatg gggctcgcag 60 gg 62 <210> SEQ ID NO 49
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 49 catccccagc
acgtacgtcc 20 <210> SEQ ID NO 50 <211> LENGTH: 132
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 50 gggcatgtgt gagttttgtc tgatcccccg
ccaccggaac ctccaccgcc tgatccaccc 60 ccacctgatc cgccgccacc
ggacccacct ccgccggagc caccgccacc gggaaatggg 120 gctcgcagga gg 132
<210> SEQ ID NO 51 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 51 gacaaaactc acacatgccc acc 23 <210> SEQ ID NO 52
<211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 52 gcagaattct
catttacccg gag 23 <210> SEQ ID NO 53 <211> LENGTH: 152
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 53 gagttccgga gctgggcacg gtgggcatgt
gtgagttttg tctgatcccc cgccaccgga 60 acctccaccg cctgatccac
ccccacctga tccgccgcca ccggacccac ctccgccgga 120 gccaccgcca
cctcggcctt ggggtttgct gg 152 <210> SEQ ID NO 54 <211>
LENGTH: 82 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 54 cagtctggat ccggcggtgg
aggttccggt gggggtggat caaggaagag gaggaagagg 60 attgtggggg
gcaaggtgtg cc 82 <210> SEQ ID NO 55 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 55 atgtctgaat tctcatttac ccggagacag
ggagagg 37 <210> SEQ ID NO 56 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 56 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 1 5 10 <210> SEQ ID NO 57 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 57 Gly Gly Gly Gly Ser 1 5
<210> SEQ ID NO 58 <211> LENGTH: 102 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 58 actgacaagc ttgccgccac catggagaca gacacactcc tgctatgggt
actgctgctc 60 tgggttccag gttccactgg tattgtgggg ggcaaggtgt gc 102
<210> SEQ ID NO 59 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 59 actgacgcgg ccgcgccgcc accatggtct cccagg 36 <210>
SEQ ID NO 60 <211> LENGTH: 35 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 60 actgacctcg agttatcggc cttggggttt gctgg 35 <210>
SEQ ID NO 61 <211> LENGTH: 118 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 61 ractgacgga tcccccgcca ccggaacctc caccgcctga tccaccccca
cctgatccgc 60 cgccaccgga cccacctccg ccggagccac cgccacctcg
gccttggggt ttgctggc 118 <210> SEQ ID NO 62 <211>
LENGTH: 35 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 62 actgacgcgg ccgcgccgcc
accatggaga cagac 35 <210> SEQ ID NO 63 <211> LENGTH: 36
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 63 actgacctcg agttagggaa atggggctcg
caggag 36 <210> SEQ ID NO 64 <211> LENGTH: 30
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 64 agctctcgag tcatttaccc ggagacaggg 30
<210> SEQ ID NO 65 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 65 Gly Gly Gly Gly Ser Ala Leu Arg Pro Arg 1 5 10
<210> SEQ ID NO 66 <211> LENGTH: 1272 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-027 amino
acid sequence <400> SEQUENCE: 66 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg
690 695 700 Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 725 730 735 Arg Lys Arg Arg Lys Arg Ala Glu Val
Gln Leu Val Gln Ser Gly Ala 740 745 750 Glu Val Asn Lys Pro Gly Ala
Ser Val Lys Val Ser Cys Lys Ala Ser 755 760 765 Gly Tyr Thr Phe Thr
Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro 770 775 780 Gly Gln Gly
Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 785 790 795 800
Thr Asn Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp 805
810 815 Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
Asp 820 825 830 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala Leu
Tyr Asn Arg 835 840 845 Asn Asp Arg Ser Pro Asn Trp Phe Asp Pro Trp
Gly Gln Gly Thr Leu 850 855 860 Val Thr Val Ser Ser Gly Ser Ala Ser
Ala Pro Thr Leu Lys Leu Glu 865 870 875 880 Glu Gly Glu Phe Ser Glu
Ala Arg Val Gln Ala Val Leu Thr Gln Pro 885 890 895 Pro Ser Val Ser
Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 900 905 910 Gly Asn
Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro 915 920 925
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 930
935 940 Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala
Thr 945 950 955 960 Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala
Asp Tyr Tyr Cys 965 970 975 Gln Val Trp Asp Ser Ser Ser Asp His Val
Val Phe Gly Gly Gly Thr 980 985 990 Lys Leu Thr Val Leu Gly Gln Pro
Lys Ala Ala Pro Ser Val Thr Leu 995 1000 1005 Phe Pro Pro Ser Ala
Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 1010 1015 1020 Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1025 1030 1035 Gly
Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 1040 1045
1050 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
1055 1060 1065 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 1070 1075 1080 Val Thr Cys Val Val Val Asp Val Ser His Glu
Asp Pro Glu Val 1085 1090 1095 Lys Phe Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys 1100 1105 1110 Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val 1115 1120 1125 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu 1130 1135 1140 Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 1145 1150 1155 Lys
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 1160 1165
1170 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
1175 1180 1185 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala 1190 1195 1200 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr 1205 1210 1215 Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser 1220 1225 1230 Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 1235 1240 1245 Ser Cys Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln 1250 1255 1260 Lys Ser Leu
Ser Leu Ser Pro Gly Lys 1265 1270 <210> SEQ ID NO 67
<211> LENGTH: 3819 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence of FVII-027
<400> SEQUENCE: 67 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaacggcgcc gccggagcgg tggcggcgga tcaggtgggg
gtggatcagg cggtggaggt 2160 tccggtggcg ggggatccgg cggtggaggt
tccggtgggg gtggatcaag gaagaggagg 2220 aagagggcgg aagtgcagct
ggtgcagtct ggagctgagg tgaataagcc tggggcctca 2280 gtgaaggtct
cctgcaaggc ttctggatac accttcaccg gctactatat gcactgggtg 2340
cgacaggccc ctggacaagg gcttgagtgg atgggatgga tcaaccctaa cagtggtggc
2400 acaaactatg cacagaagtt tcagggctgg gtcaccatga ccagggacac
gtccatcagc 2460 accgcctaca tggagctgag caggctgaga tctgacgaca
cggccgtgta ttactgtgcg 2520 agaggccgtg ctttgtataa ccggaacgac
cggtccccca actggttcga cccctggggc 2580 cagggaaccc tggtcaccgt
ctcctcaggg agtgcatccg ccccaaccct taagcttgaa 2640 gaaggtgaat
tctcagaagc acgcgtacag gctgtgctga ctcagccgcc ctcggtgtca 2700
gtggccccag gacagacggc caggattacc tgtgggggaa acaacattgg aagtaaaagt
2760 gtgcagtggt accagcagaa gccaggccag gcccctgtgc tggtcgtcta
tgatgatagc 2820 gaccggccct cagggatccc tgagcgattc tctggctcca
actctgggaa catggccacc 2880 ctgaccatca gcagggtcga agccggggat
gaggccgact attactgtca ggtgtgggat 2940 agtagtagtg atcatgtggt
attcggcgga gggaccaagc tgaccgtcct aggtcagccc 3000 aaggctgccc
cctcggtcac tctgttcccg ccgtccgcgg ccgctggtgg cggtggctcc 3060
ggcggaggtg ggtccggtgg cggcggatca ggtgggggtg gatcaggcgg tggaggttcc
3120 ggtggcgggg gatcagacaa aactcacaca tgcccaccgt gcccagcacc
tgaactcctg 3180 ggaggaccgt cagtcttcct cttcccccca aaacccaagg
acaccctcat gatctcccgg 3240 acccctgagg tcacatgcgt ggtggtggac
gtgagccacg aagaccctga ggtcaagttc 3300 aactggtacg tggacggcgt
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 3360 tacaacagca
cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 3420
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc
3480 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc
cccatcccgc 3540 gatgagctga ccaagaacca ggtcagcctg acctgcctgg
tcaaaggctt ctatcccagc 3600 gacatcgccg tggagtggga gagcaatggg
cagccggaga acaactacaa gaccacgcct 3660 cccgtgttgg actccgacgg
ctccttcttc ctctacagca agctcaccgt ggacaagagc 3720 aggtggcagc
aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 3780
tacacgcaga agagcctctc cctgtctccg ggtaaatga 3819 <210> SEQ ID
NO 68 <211> LENGTH: 577 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: Genscript-FVII-027-1 DNA
sequence <400> SEQUENCE: 68 gaagagcctc tccctgtctc cgggtaaacg
gcgccgccgg agcggtggcg gcggatcagg 60 tgggggtgga tcaggcggtg
gaggttccgg tggcggggga tccggcggtg gaggttccgg 120 tgggggtgga
tcaaggaaga ggaggaagag ggcggaagtg cagctggtgc agtctggagc 180
tgaggtgaat aagcctgggg cctcagtgaa ggtctcctgc aaggcttctg gatacacctt
240 caccggctac tatatgcact gggtgcgaca ggcccctgga caagggcttg
agtggatggg 300 atggatcaac cctaacagtg gtggcacaaa ctatgcacag
aagtttcagg gctgggtcac 360 catgaccagg gacacgtcca tcagcaccgc
ctacatggag ctgagcaggc tgagatctga 420 cgacacggcc gtgtattact
gtgcgagagg ccgtgctttg tataaccgga acgaccggtc 480 ccccaactgg
ttcgacccct ggggccaggg aaccctggtc accgtctcct cagggagtgc 540
atccgcccca acccttaagc ttgaagaagg tgaattc 577 <210> SEQ ID NO
69 <211> LENGTH: 1179 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: Genscript-FVII-026-2 DNA
sequence <400> SEQUENCE: 69 gaattctcag aagcacgcgt acaggctgtg
ctgactcagc cgccctcggt gtcagtggcc 60 ccaggacaga cggccaggat
tacctgtggg ggaaacaaca ttggaagtaa aagtgtgcag 120 tggtaccagc
agaagccagg ccaggcccct gtgctggtcg tctatgatga tagcgaccgg 180
ccctcaggga tccctgagcg attctctggc tccaactctg ggaacatggc caccctgacc
240 atcagcaggg tcgaagccgg ggatgaggcc gactattact gtcaggtgtg
ggatagtagt 300 agtgatcatg tggtattcgg cggagggacc aagctgaccg
tcctaggtca gcccaaggct 360 gccccctcgg tcactctgtt cccgccgtcc
gcggccgctg gtggcggtgg ctccggcgga 420 ggtgggtccg gtggcggcgg
atcaggtggg ggtggatcag gcggtggagg ttccggtggc 480 gggggatcag
acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggagga 540
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct
600 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa
gttcaactgg 660 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc
cgcgggagga gcagtacaac 720 agcacgtacc gtgtggtcag cgtcctcacc
gtcctgcacc aggactggct gaatggcaag 780 gagtacaagt gcaaggtctc
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 840 aaagccaaag
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgcgatgag 900
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc
960 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac
gcctcccgtg 1020 ttggactccg acggctcctt cttcctctac agcaagctca
ccgtggacaa gagcaggtgg 1080 cagcagggga acgtcttctc atgctccgtg
atgcatgagg ctctgcacaa ccactacacg 1140 cagaagagcc tctccctgtc
tccgggtaaa tgagaattc 1179 <210> SEQ ID NO 70 <211>
LENGTH: 1250 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-037 amino acid sequence. <400>
SEQUENCE: 70 Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu
Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu
Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala
Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys
Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe
Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser
Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly
Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105
110 Ala Phe Glu Gly Arg Asn Cys Glu His Lys Asp Asp Gln Leu Ile Cys
115 120 125 Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His
Thr Gly 130 135 140 Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser
Leu Leu Ala Asp 145 150 155 160 Gly Val Ser Cys Thr Pro Thr Val Glu
Tyr Pro Cys Gly Lys Ile Pro 165 170 175 Ile Leu Glu Lys Arg Asn Ala
Ser Lys Pro Gln Gly Arg Ile Val Gly 180 185 190 Gly Lys Val Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu 195 200 205 Val Asn Gly
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp 210 215 220 Val
Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn 225 230
235 240 Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly
Asp 245 250 255 Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val 260 265 270 Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro 275 280 285 Val Val Leu Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr 290 295 300 Phe Ser Glu Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly 305 310 315 320 Trp Gly Gln Leu
Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val 325 330 335 Leu Asn
Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg 340 345 350
Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly 355
360 365 Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro 370 375 380 His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser 385 390 395 400 Trp Gly Gln Gly Cys Ala Thr Val Gly His
Phe Gly Val Tyr Thr Arg 405 410 415 Val Ser Gln Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro 420 425 430 Arg Pro Gly Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser 435 440 445 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 465 470 475
480 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
485 490 495 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val 500 505 510 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe 515 520 525 Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro 530 535 540 Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr 545 550 555 560 Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 565 570 575 Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 580 585 590 Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 595 600
605 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
610 615 620 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro 625 630 635 640 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser 645 650 655 Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln 660 665 670 Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His 675 680 685 Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 690 695 700 Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 725
730 735 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met 740 745 750 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His 755 760 765 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
Asp Gly Val Glu Val 770 775 780 His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr 785 790 795 800 Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly 805 810 815 Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 820 825 830 Glu Lys
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 835 840 845
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 850
855 860 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu 865 870 875 880 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro 885 890 895 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val 900 905 910 Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val Met 915 920 925 His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 930 935 940 Pro Gly Lys Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 945 950 955 960 Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 965 970
975 Ser Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Asn Lys Pro
980 985 990 Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr 995 1000 1005 Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu 1010 1015 1020 Glu Trp Met Gly Trp Ile Asn Pro Asn
Ser Gly Gly Thr Asn Tyr 1025 1030 1035 Ala Gln Lys Phe Gln Gly Trp
Val Thr Met Thr Arg Asp Thr Ser 1040 1045 1050 Ile Ser Thr Ala Tyr
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 1055 1060 1065 Thr Ala Val
Tyr Tyr Cys Ala Arg Gly Arg Ala Leu Tyr Asn Arg 1070 1075 1080 Asn
Asp Arg Ser Pro Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr 1085 1090
1095 Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Thr Leu Lys
1100 1105 1110 Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ala
Val Leu 1115 1120 1125 Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly
Gln Thr Ala Arg 1130 1135 1140 Ile Thr Cys Gly Gly Asn Asn Ile Gly
Ser Lys Ser Val Gln Trp 1145 1150 1155 Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu Val Val Tyr Asp 1160 1165 1170 Asp Ser Asp Arg Pro
Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 1175 1180 1185 Asn Ser Gly
Asn Met Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 1190 1195 1200 Gly
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser 1205 1210
1215 Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
1220 1225 1230 Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
Ser Ala 1235 1240 1245 Ala Ala 1250 <210> SEQ ID NO 71
<211> LENGTH: 3756 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FIX-037 DNA sequence
<400> SEQUENCE: 71 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaaggtggc ggtggctccg
gcggaggtgg gtccggtggc 2880 ggcggatcag gtgggggtgg atcaggcggt
ggaggttccg gtggcggggg atcagcggaa 2940 gtgcagctgg tgcagtctgg
agctgaggtg aataagcctg gggcctcagt gaaggtctcc 3000 tgcaaggctt
ctggatacac cttcaccggc tactatatgc actgggtgcg acaggcccct 3060
ggacaagggc ttgagtggat gggatggatc aaccctaaca gtggtggcac aaactatgca
3120 cagaagtttc agggctgggt caccatgacc agggacacgt ccatcagcac
cgcctacatg 3180 gagctgagca ggctgagatc tgacgacacg gccgtgtatt
actgtgcgag aggccgtgct 3240 ttgtataacc ggaacgaccg gtcccccaac
tggttcgacc cctggggcca gggaaccctg 3300 gtcaccgtct cctcagggag
tgcatccgcc ccaaccctta agcttgaaga aggtgaattt 3360 tcagaagcac
gcgtacaggc tgtgctgact cagccgccct cggtgtcagt ggccccagga 3420
cagacggcca ggattacctg tgggggaaac aacattggaa gtaaaagtgt gcagtggtac
3480 cagcagaagc caggccaggc ccctgtgctg gtcgtctatg atgatagcga
ccggccctca 3540 gggatccctg agcgattctc tggctccaac tctgggaaca
tggccaccct gaccatcagc 3600 agggtcgaag ccggggatga ggccgactat
tactgtcagg tgtgggatag tagtagtgat 3660 catgtggtat tcggcggagg
gaccaagctg accgtcctag gtcagcccaa ggctgccccc 3720 tcggtcactc
tgttcccgcc gtccgcggcc gcttga 3756 <210> SEQ ID NO 72
<211> LENGTH: 1174 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-053 amino acid
sequence <400> SEQUENCE: 72 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Glu
Val Gln Leu Val Gln Ser Gly Ala Glu Val 20 25 30 Asn Lys Pro Gly
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 35 40 45 Thr Phe
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 50 55 60
Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 65
70 75 80 Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp
Thr Ser 85 90 95 Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
Ser Asp Asp Thr 100 105 110 Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala
Leu Tyr Asn Arg Asn Asp 115 120 125 Arg Ser Pro Asn Trp Phe Asp Pro
Trp Gly Gln Gly Thr Leu Val Thr 130 135 140 Val Ser Ser Gly Ser Ala
Ser Ala Pro Thr Leu Lys Leu Glu Glu Gly 145 150 155 160 Glu Phe Ser
Glu Ala Arg Val Gln Ala Val Leu Thr Gln Pro Pro Ser 165 170 175 Val
Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 180 185
190 Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln
195 200 205 Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser
Gly Ile 210 215 220 Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met
Ala Thr Leu Thr 225 230 235 240 Ile Ser Arg Val Glu Ala Gly Asp Glu
Ala Asp Tyr Tyr Cys Gln Val 245 250 255 Trp Asp Ser Ser Ser Asp His
Val Val Phe Gly Gly Gly Thr Lys Leu 260 265 270 Thr Val Leu Gly Gln
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 275 280 285 Pro Ser Ala
Ala Ala Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp 290 295 300 Gly
Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys 305 310
315 320 Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu
Gly 325 330 335 Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys
Val Asn Glu 340 345 350 Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His
Thr Gly Thr Lys Arg 355 360 365 Ser Cys Arg Cys His Glu Gly Tyr Ser
Leu Leu Ala Asp Gly Val Ser 370 375 380 Cys Thr Pro Thr Val Glu Tyr
Pro Cys Gly Lys Ile Pro Ile Leu Glu 385 390 395 400 Lys Arg Asn Ala
Ser Lys Pro Gln Gly Arg Arg Lys Arg Arg Lys Arg 405 410 415 Ile Val
Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 420 425 430
Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 435
440 445 Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys
Asn 450 455 460 Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu
Ser Glu His 465 470 475 480 Asp Gly Asp Glu Gln Ser Arg Arg Val Ala
Gln Val Ile Ile Pro Ser 485 490 495 Thr Tyr Val Pro Gly Thr Thr Asn
His Asp Ile Ala Leu Leu Arg Leu 500 505 510 His Gln Pro Val Val Leu
Thr Asp His Val Val Pro Leu Cys Leu Pro 515 520 525 Glu Arg Thr Phe
Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu 530 535 540 Val Ser
Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 545 550 555
560 Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln
565 570 575 Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr
Met Phe 580 585 590 Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys
Lys Gly Asp Ser 595 600 605 Gly Gly Pro His Ala Thr His Tyr Arg Gly
Thr Trp Tyr Leu Thr Gly 610 615 620 Ile Val Ser Trp Gly Gln Gly Cys
Ala Thr Val Gly His Phe Gly Val 625 630 635 640 Tyr Thr Arg Val Ser
Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 645 650 655 Ser Glu Pro
Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly 660 665 670 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 675 680
685 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His
690 695 700 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val 705 710 715 720 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr 725 730 735 Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu 740 745 750 Val Lys Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys 755 760 765 Thr Lys Pro Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 770 775 780 Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 785 790 795 800
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 805
810 815 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro 820 825 830 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu 835 840 845 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn 850 855 860 Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser 865 870 875 880 Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 885 890 895 Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 900 905 910 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 915 920 925
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 930
935 940 Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 945 950 955 960 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 965 970 975 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 980 985 990 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 995 1000 1005 Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 1010 1015 1020 Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 1025 1030 1035 Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 1040 1045
1050 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
1055 1060 1065 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Asp 1070 1075 1080 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly 1085 1090 1095 Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln 1100 1105 1110 Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp 1115 1120 1125 Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 1130 1135 1140 Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 1145 1150 1155 Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 1160 1165
1170 Lys <210> SEQ ID NO 73 <211> LENGTH: 3525
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-053 DNA sequence <400> SEQUENCE: 73
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcggaagtgc agctggtgca gtctggagct gaggtgaata agcctggggc
ctcagtgaag 120 gtctcctgca aggcttctgg atacaccttc accggctact
atatgcactg ggtgcgacag 180 gcccctggac aagggcttga gtggatggga
tggatcaacc ctaacagtgg tggcacaaac 240 tatgcacaga agtttcaggg
ctgggtcacc atgaccaggg acacgtccat cagcaccgcc 300 tacatggagc
tgagcaggct gagatctgac gacacggccg tgtattactg tgcgagaggc 360
cgtgctttgt ataaccggaa cgaccggtcc cccaactggt tcgacccctg gggccaggga
420 accctggtca ccgtctcctc agggagtgca tccgccccaa cccttaaact
tgaagaaggt 480 gaattttcag aagcacgcgt acaggctgtg ctgactcagc
cgccctcggt gtcagtggcc 540 ccaggacaga cggccaggat tacctgtggg
ggaaacaaca ttggaagtaa aagtgtgcag 600 tggtaccagc agaagccagg
ccaggcccct gtgctggtcg tctatgatga tagcgaccgg 660 ccctcaggga
tccctgagcg attctctggc tccaactctg ggaacatggc caccctgacc 720
atcagcaggg tcgaagccgg ggatgaggcc gactattact gtcaggtgtg ggatagtagt
780 agtgatcatg tggtattcgg cggagggacc aagctgaccg tcctaggtca
gcccaaggct 840 gccccctcgg tcactctgtt cccgccgtcc gcggccgcta
ggacgaagct gttctggatt 900 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 960 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 1020 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 1080
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
1140 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 1200 aaaagaaatg ccagcaaacc ccaaggccga aggaagagga
ggaagaggat tgtggggggc 1260 aaggtgtgcc ccaaagggga gtgtccatgg
caggtcctgt tgttggtgaa tggagctcag 1320 ttgtgtgggg ggaccctgat
caacaccatc tgggtggtct ccgcggccca ctgtttcgac 1380 aaaatcaaga
actggaggaa cctgatcgcg gtgctgggcg agcacgacct cagcgagcac 1440
gacggggatg agcagagccg gcgggtggcg caggtcatca tccccagcac gtacgtcccg
1500 ggcaccacca accacgacat cgcgctgctc cgcctgcacc agcccgtggt
cctcactgac 1560 catgtggtgc ccctctgcct gcccgaacgg acgttctctg
agaggacgct ggccttcgtg 1620 cgcttctcat tggtcagcgg ctggggccag
ctgctggacc gtggcgccac ggccctggag 1680 ctcatggtcc tcaacgtgcc
ccggctgatg acccaggact gcctgcagca gtcacggaag 1740 gtgggagact
ccccaaatat cacggagtac atgttctgtg ccggctactc ggatggcagc 1800
aaggactcct gcaaggggga cagtggaggc ccacatgcca cccactaccg gggcacgtgg
1860 tacctgacgg gcatcgtcag ctggggccag ggctgcgcaa ccgtgggcca
ctttggggtg 1920 tacaccaggg tctcccagta catcgagtgg ctgcaaaagc
tcatgcgctc agagccacgc 1980 ccaggagtcc tcctgcgagc cccatttccc
ggtggcggtg gctccggcgg aggtgggtcc 2040 ggtggcggcg gatcaggtgg
gggtggatca ggcggtggag gttccggtgg cgggggatcc 2100 gacaaaactc
acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc 2160
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
2220 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 2280 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 2340 cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 2400 tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 2460 gggcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 2520
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
2580 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gttggactcc 2640 gacggctcct tcttcctcta cagcaagctc accgtggaca
agagcaggtg gcagcagggg 2700 aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 2760 ctctccctgt ctccgggtaa
aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 2820 ggttccggtg
gcgggggatc cgacaaaact cacacatgcc caccgtgccc agcacctgaa 2880
ctcctgggag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc
2940 tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga
ccctgaggtc 3000 aagttcaact ggtacgtgga cggcgtggag gtgcataatg
ccaagacaaa gccgcgggag 3060 gagcagtaca acagcacgta ccgtgtggtc
agcgtcctca ccgtcctgca ccaggactgg 3120 ctgaatggca aggagtacaa
gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 3180 aaaaccatct
ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 3240
tcccgcgatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat
3300 cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa
ctacaagacc 3360 acgcctcccg tgttggactc cgacggctcc ttcttcctct
acagcaagct caccgtggac 3420 aagagcaggt ggcagcaggg gaacgtcttc
tcatgctccg tgatgcatga ggctctgcac 3480 aaccactaca cgcagaagag
cctctccctg tctccgggta aatga 3525 <210> SEQ ID NO 74
<211> LENGTH: 982 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct: FVII-044 amino acid sequence
<400> SEQUENCE: 74 Met Val Ser Gln Ala Leu Arg Leu Leu Cys
Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val
Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg
Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu
Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg
Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80
Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85
90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu
Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp
Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr
Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His
Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr
Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu
Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185 190 Gly Gly
Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 195 200 205
Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 210
215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp
Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser
Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val Ala Gln Val
Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr Asn His Asp
Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val Leu Thr Asp
His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr Phe Ser Glu
Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310 315 320 Gly
Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 325 330
335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser
340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe
Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly
Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg Gly Thr Trp
Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln Gly Cys Ala
Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val Ser Gln Tyr
Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430 Pro Arg Pro
Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435 440 445 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455
460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys
465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555 560 Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 565 570 575
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 580
585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 690 695 700
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 705
710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800 Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805 810 815 Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 820 825
830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925 Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930 935 940 Ser
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 945 950
955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu Arg Trp Ala
Leu 965 970 975 His Asn Leu Cys Gly Gly 980 <210> SEQ ID NO
75 <211> LENGTH: 2949 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-044 DNA sequence
<400> SEQUENCE: 75 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaaggtggc ggcggatcag
gtgggggtgg atcaggcggt 2880 ggaggttccg gtggcggggg atcagcctgc
accgagcggt gggccctgca caacctgtgc 2940 ggcgggtga 2949 <210>
SEQ ID NO 76 <211> LENGTH: 982 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-045 amino
acid sequence <400> SEQUENCE: 76 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805
810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930
935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu
Arg Met Ala Leu 965 970 975 His Asn Leu Cys Gly Gly 980 <210>
SEQ ID NO 77 <211> LENGTH: 2949 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-045 DNA
sequence <400> SEQUENCE: 77 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaaggtggc ggcggatcag
gtgggggtgg atcaggcggt 2880 ggaggttccg gtggcggggg atcagcctgc
accgagcgga tggccctgca caacctgtgc 2940 ggcgggtga 2949 <210>
SEQ ID NO 78 <211> LENGTH: 982 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-046 amino
acid sequence <400> SEQUENCE: 78 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805
810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930
935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu
Arg Asp Ala Leu 965 970 975 His Asn Leu Cys Gly Gly 980 <210>
SEQ ID NO 79 <211> LENGTH: 2949 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-046 DNA
sequence <400> SEQUENCE: 79 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaaggtggc ggcggatcag
gtgggggtgg atcaggcggt 2880 ggaggttccg gtggcggggg atcagcctgc
accgagcggg acgccctgca caacctgtgc 2940 ggcgggtga 2949 <210>
SEQ ID NO 80 <211> LENGTH: 1000 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-047 amino
acid sequence <400> SEQUENCE: 80 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Cys Thr Glu Arg 725 730 735 Trp Ala Leu His Asn Leu Cys Gly Gly
Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly Gly Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775 780 Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 785 790 795 800
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 805
810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895 Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900 905 910 Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 915 920 925
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 930
935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu Ser Leu Ser Pro Gly Lys
995 1000 <210> SEQ ID NO 81 <211> LENGTH: 3003
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-047 DNA sequence <400> SEQUENCE: 81
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaaggcggtg
gcggttcagg tggaggaggg tcaggcggtg gtggatccgg cgggggcgga 2160
tccggtggcg gagggtcagg cggtggcgga tcagcctgca ccgagcggtg ggccctgcac
2220 aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg
atcaggtggg 2280 ggtggatcag gcggtggagg ttccggtggc gggggatccg
acaaaactca cacatgccca 2340 ccgtgcccag caccggaact cctgggcgga
ccgtcagtct tcctcttccc cccaaaaccc 2400 aaggacaccc tcatgatctc
ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 2460 cacgaagacc
ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 2520
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
2580 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 2640 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag
ggcagccccg agaaccacag 2700 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 2760 ctggtcaaag gcttctatcc
cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2820 gagaacaact
acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac 2880
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
2940 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaaa 3000 tga 3003 <210> SEQ ID NO 82 <400>
SEQUENCE: 82 000 <210> SEQ ID NO 83 <400> SEQUENCE: 83
000 <210> SEQ ID NO 84 <211> LENGTH: 1000 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-048 amino acid sequence. <400> SEQUENCE: 84 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Ile Val 180 185 190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp
Gln Val Leu Leu 195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly
Thr Leu Ile Asn Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys
Phe Asp Lys Ile Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val
Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln
Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val
Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280
285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg
290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu
Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr
Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr
Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro
Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly
Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala
Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400
Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405
410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser
Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly
Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530
535 540 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu 545 550 555 560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys 565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650
655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
660 665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn 675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys Gly Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ala Cys Thr Glu Arg 725 730 735 Met Ala Leu His Asn
Leu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775
780 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
785 790 795 800 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val 805 810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900
905 910 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser 915 920 925 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr 930 935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu Ser Leu
Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 85 <211>
LENGTH: 3003 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence of FVII-048 <400> SEQUENCE:
85 atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg
ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc
accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc
ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga
gatcttcaag gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg
atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300
gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag
360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga
gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg
aggggtactc tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa
tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc
ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat
ggcaggtcct gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660
atcaacacca tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg
720 aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga
tgagcagagc 780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc
cgggcaccac caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg
gtcctcactg accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc
tgagaggacg ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc
agctgctgga ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020
ccccggctga tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat
1080 atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc
ctgcaagggg 1140 gacagtggag gcccacatgc cacccactac cggggcacgt
ggtacctgac gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc
cactttgggg tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa
gctcatgcgc tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc
ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380
gggggtggat caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc
1440 ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt
ccccccaaaa 1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca
catgcgtggt ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac
tggtacgtgg acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga
ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc
accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca
1800 caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt
cagcctgacc 1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg
agtgggagag caatgggcag 1920 ccggagaaca actacaagac cacgcctccc
gtgttggact ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga
caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg
aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 2100
aaaggcggtg gcggttcagg tggaggaggg tcaggcggtg gtggatccgg cgggggcgga
2160 tccggtggcg gagggtcagg cggtggcgga tcagcctgca ccgagcggat
ggccctgcac 2220 aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg
gtggcggcgg atcaggtggg 2280 ggtggatcag gcggtggagg ttccggtggc
gggggatccg acaaaactca cacatgccca 2340 ccgtgcccag caccggaact
cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc 2400 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 2460
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
2520 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 2580 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 2640 ctcccagccc ccatcgagaa aaccatctcc
aaagccaaag ggcagccccg agaaccacag 2700 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 2760 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2820
gagaacaact acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac
2880 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 2940 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaaa 3000 tga 3003 <210> SEQ ID NO 86
<211> LENGTH: 1000 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-049 amino acid
sequence <400> SEQUENCE: 86 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Cys Thr Glu Arg 725 730 735 Asp Ala Leu His Asn Leu Cys Gly Gly
Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly Gly Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775 780 Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 785 790 795 800
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 805
810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895 Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900 905 910 Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 915 920 925
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 930
935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu Ser Leu Ser Pro Gly Lys
995 1000 <210> SEQ ID NO 87 <211> LENGTH: 3003
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence of FVII-049 <400> SEQUENCE: 87
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaaggcggtg
gcggttcagg tggaggaggg tcaggcggtg gtggatccgg cgggggcgga 2160
tccggtggcg gagggtcagg cggtggcgga tcagcctgca ccgagcggga cgccctgcac
2220 aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg
atcaggtggg 2280 ggtggatcag gcggtggagg ttccggtggc gggggatccg
acaaaactca cacatgccca 2340 ccgtgcccag caccggaact cctgggcgga
ccgtcagtct tcctcttccc cccaaaaccc 2400 aaggacaccc tcatgatctc
ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 2460 cacgaagacc
ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 2520
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
2580 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 2640 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag
ggcagccccg agaaccacag 2700 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 2760 ctggtcaaag gcttctatcc
cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2820 gagaacaact
acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac 2880
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
2940 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaaa 3000 tga 3003 <210> SEQ ID NO 88 <211>
LENGTH: 948 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-011 amino acid sequence <400>
SEQUENCE: 88 Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu
Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu
Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala
Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys
Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe
Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser
Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly
Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105
110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile
115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp
His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr
Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val
Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn
Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185 190 Gly Gly Lys Val Cys
Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 195 200 205 Leu Val Asn
Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 210 215 220 Trp
Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 225 230
235 240 Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp
Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro
Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu
Leu Arg Leu His Gln 275 280 285 Pro Val Val Leu Thr Asp His Val Val
Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr Phe Ser Glu Arg Thr Leu
Ala Phe Val Arg Phe Ser Leu Val Ser 305 310 315 320 Gly Trp Gly Gln
Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 325 330 335 Val Leu
Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 340 345 350
Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355
360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly
Gly 370 375 380 Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr
Gly Ile Val 385 390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly
His Phe Gly Val Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp
Leu Gln Lys Leu Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu
Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 465 470 475
480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 500 505 510 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu 545 550 555 560 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 565 570 575 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600
605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 690 695 700 Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 705 710 715 720
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 725
730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser 755 760 765 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu 770 775 780 Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800 Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn 805 810 815 Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 820 825 830 Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 835 840 845
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 850
855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val 865 870 875 880 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val 915 920 925 Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930 935 940 Ser Pro Gly Lys
945 <210> SEQ ID NO 89 <211> LENGTH: 2847 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-011 DNA sequence <400> SEQUENCE: 89 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg
gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg
aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt
ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg
cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780
cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac
840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt
gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg
tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc
acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga
ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt
acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140
gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc
1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag
ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac
gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg tggctccggc
ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat caggcggtgg
aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440 ccaccgtgcc
cagctccgga actcctgggc ggaccgtcag tcttcctctt ccccccaaaa 1500
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg
1560 agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga
ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac aacagcacgt
accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg gctgaatggc
aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag cccccatcga
gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800 caggtgtaca
ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 1860
tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag
1920 ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc
cttcttcctc 1980 tacagcaagc tcaccgtgga caagagcagg tggcagcagg
ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca caaccactac
acgcagaaga gcctctccct gtctccgggt 2100 aaaggtggcg gcggatcagg
tgggggtgga tcaggcggtg gaggttccgg tggcggggga 2160 tcagacaaaa
ctcacacatg cccaccgtgc ccagcacctg aactcctggg aggaccgtca 2220
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc
2280 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa
ctggtacgtg 2340 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg
aggagcagta caacagcacg 2400 taccgtgtgg tcagcgtcct caccgtcctg
caccaggact ggctgaatgg caaggagtac 2460 aagtgcaagg tctccaacaa
agccctccca gcccccatcg agaaaaccat ctccaaagcc 2520 aaagggcagc
cccgagaacc acaggtgtac accctgcccc catcccgcga tgagctgacc 2580
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg
2640 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc
cgtgttggac 2700 tccgacggct ccttcttcct ctacagcaag ctcaccgtgg
acaagagcag gtggcagcag 2760 gggaacgtct tctcatgctc cgtgatgcat
gaggctctgc acaaccacta cacgcagaag 2820 agcctctccc tgtctccggg taaatga
2847 <210> SEQ ID NO 90 <211> LENGTH: 1457 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: B
domain deleted FVIII amino acid sequence <400> SEQUENCE: 90
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5
10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu
Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val
Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe
Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe
Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp
Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp
Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val
Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu
Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135
140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu
145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu
Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu
Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly
Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile
Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser
Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala
Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260
265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser
Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg
Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala
Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe
Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr
Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met
Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr
Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385
390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr
Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser
Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr
Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys
Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro
Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile
Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His
Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505
510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe
515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys
Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val
Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro
Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn
Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val
Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln
Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro
Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630
635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr
Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser
Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr
Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val
Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys
His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu
Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr
Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 755
760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp
Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met
Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn
Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr Arg His Tyr Phe
Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr Gly Met Ser Ser
Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845 Ser Gly Ser Val
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850 855 860 Asp Gly
Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 865 870 875
880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile
885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe
Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly
Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys
Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met Ala Pro Thr Lys
Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala Tyr Phe Ser Asp
Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970 975 Ile Gly Pro
Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 980 985 990 Gly
Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 995
1000 1005 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg
Asn 1010 1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro
Thr Phe Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly
Tyr Ile Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln
Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser
Asn Glu Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val
Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110
Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115
1120 1125 Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr
Ser 1130 1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly
His Ile Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr
Gly Gln Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser
Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser
Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His
Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230
Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235
1240 1245 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His
Asn 1250 1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg
Leu His Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg
Met Glu Leu Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser Cys Ser Met
Pro Leu Gly Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser Asp Ala Gln
Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met Phe Ala Thr
Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 1325 1330 1335 Gly Arg
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1340 1345 1350
Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1355
1360 1365 Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val
Lys 1370 1375 1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln
Trp Thr Leu 1385 1390 1395 Phe Phe Gln Asn Gly Lys Val Lys Val Phe
Gln Gly Asn Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val Val Asn Ser
Leu Asp Pro Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu Arg Ile His
Pro Gln Ser Trp Val His Gln Ile Ala 1430 1435 1440 Leu Arg Met Glu
Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1445 1450 1455 <210>
SEQ ID NO 91 <211> LENGTH: 2351 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: Full length
FVIII amino acid sequence <400> SEQUENCE: 91 Met Gln Ile Glu
Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys Phe
Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35
40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val
Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu
Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu
Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val Ile
Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His Ala
Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu Tyr
Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys Val
Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155 160
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165
170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu
Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys
Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala
Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys Asn
Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg Ala
Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg Ser
Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr Trp
His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280 285
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 290
295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu
Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser
Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val Asp
Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn Glu
Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu Met
Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe Ile
Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385 390 395 400 Trp
Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405 410
415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn
420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg
Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala
Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly
Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn Gln
Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr Asp
Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val Lys
His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525 Lys
Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530 535
540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg
545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys
Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser
Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu Asn
Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu Pro
Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro Glu Phe Gln Ala
Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630 635 640 Phe Asp
Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 645 650 655
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 660
665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu
Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met
Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp
Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu Leu Lys Val Ser
Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr Glu Asp Ser Tyr
Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750 Asn Asn Ala Ile
Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 755 760 765 Ser Thr
Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 770 775 780
Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 785
790 795 800 Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg
Gln Ser 805 810 815 Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln
Glu Ala Lys Tyr 820 825 830 Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly
Ala Ile Asp Ser Asn Asn 835 840 845 Ser Leu Ser Glu Met Thr His Phe
Arg Pro Gln Leu His His Ser Gly 850 855 860 Asp Met Val Phe Thr Pro
Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 865 870 875 880 Lys Leu Gly
Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 885 890 895 Val
Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 900 905
910 Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met
915 920 925 Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly
Lys Lys 930 935 940 Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser
Leu Ser Glu Glu 945 950 955 960 Asn Asn Asp Ser Lys Leu Leu Glu Ser
Gly Leu Met Asn Ser Gln Glu 965 970 975 Ser Ser Trp Gly Lys Asn Val
Ser Ser Thr Glu Ser Gly Arg Leu Phe 980 985 990 Lys Gly Lys Arg Ala
His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala 995 1000 1005 Leu Phe
Lys Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser 1010 1015 1020
Asn Asn Ser Ala Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser 1025
1030 1035 Leu Leu Ile Glu Asn Ser Pro Ser Val Trp Gln Asn Ile Leu
Glu 1040 1045 1050 Ser Asp Thr Glu Phe Lys Lys Val Thr Pro Leu Ile
His Asp Arg 1055 1060 1065 Met Leu Met Asp Lys Asn Ala Thr Ala Leu
Arg Leu Asn His Met 1070 1075 1080 Ser Asn Lys Thr Thr Ser Ser Lys
Asn Met Glu Met Val Gln Gln 1085 1090 1095 Lys Lys Glu Gly Pro Ile
Pro Pro Asp Ala Gln Asn Pro Asp Met 1100 1105 1110 Ser Phe Phe Lys
Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile 1115 1120 1125 Gln Arg
Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 1130 1135 1140
Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu 1145
1150 1155 Gly Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly
Lys 1160 1165 1170 Gly Glu Phe Thr Lys Asp Val Gly Leu Lys Glu Met
Val Phe Pro 1175 1180 1185 Ser Ser Arg Asn Leu Phe Leu Thr Asn Leu
Asp Asn Leu His Glu 1190 1195 1200 Asn Asn Thr His Asn Gln Glu Lys
Lys Ile Gln Glu Glu Ile Glu 1205 1210 1215 Lys Lys Glu Thr Leu Ile
Gln Glu Asn Val Val Leu Pro Gln Ile 1220 1225 1230 His Thr Val Thr
Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu 1235 1240 1245 Leu Ser
Thr Arg Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr 1250 1255 1260
Ala Pro Val Leu Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn 1265
1270 1275 Arg Thr Lys Lys His Thr Ala His Phe Ser Lys Lys Gly Glu
Glu 1280 1285 1290 Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr Lys Gln
Ile Val Glu 1295 1300 1305 Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro
Asn Thr Ser Gln Gln 1310 1315 1320 Asn Phe Val Thr Gln Arg Ser Lys
Arg Ala Leu Lys Gln Phe Arg 1325 1330 1335 Leu Pro Leu Glu Glu Thr
Glu Leu Glu Lys Arg Ile Ile Val Asp 1340 1345 1350 Asp Thr Ser Thr
Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro 1355 1360 1365 Ser Thr
Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 1370 1375 1380
Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser 1385
1390 1395 Ile Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val
Ser 1400 1405 1410 Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg
Val Leu Phe 1415 1420 1425 Gln Asp Asn Ser Ser His Leu Pro Ala Ala
Ser Tyr Arg Lys Lys 1430 1435 1440 Asp Ser Gly Val Gln Glu Ser Ser
His Phe Leu Gln Gly Ala Lys 1445 1450 1455 Lys Asn Asn Leu Ser Leu
Ala Ile Leu Thr Leu Glu Met Thr Gly 1460 1465 1470 Asp Gln Arg Glu
Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser 1475 1480 1485 Val Thr
Tyr Lys Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp 1490 1495 1500
Leu Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys Val His 1505
1510 1515 Ile Tyr Gln Lys Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly
Ser 1520 1525 1530 Pro Gly His Leu Asp Leu Val Glu Gly Ser Leu Leu
Gln Gly Thr 1535 1540 1545 Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn
Arg Pro Gly Lys Val 1550 1555 1560 Pro Phe Leu Arg Val Ala Thr Glu
Ser Ser Ala Lys Thr Pro Ser 1565 1570 1575 Lys Leu Leu Asp Pro Leu
Ala Trp Asp Asn His Tyr Gly Thr Gln 1580 1585 1590 Ile Pro Lys Glu
Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu Lys 1595 1600 1605 Thr Ala
Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys 1610 1615 1620
Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys 1625
1630 1635 Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu
Arg 1640 1645 1650 Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His
Gln Arg Glu 1655 1660 1665 Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln
Glu Glu Ile Asp Tyr 1670 1675 1680 Asp Asp Thr Ile Ser Val Glu Met
Lys Lys Glu Asp Phe Asp Ile 1685 1690 1695 Tyr Asp Glu Asp Glu Asn
Gln Ser Pro Arg Ser Phe Gln Lys Lys 1700 1705 1710 Thr Arg His Tyr
Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 1715 1720 1725 Gly Met
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser 1730 1735 1740
Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 1745
1750 1755 Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn
Glu 1760 1765 1770 His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu
Val Glu Asp 1775 1780 1785 Asn Ile Met Val Thr Phe Arg Asn Gln Ala
Ser Arg Pro Tyr Ser 1790 1795 1800 Phe Tyr Ser Ser Leu Ile Ser Tyr
Glu Glu Asp Gln Arg Gln Gly 1805 1810 1815 Ala Glu Pro Arg Lys Asn
Phe Val Lys Pro Asn Glu Thr Lys Thr 1820 1825 1830 Tyr Phe Trp Lys
Val Gln His His Met Ala Pro Thr Lys Asp Glu 1835 1840 1845 Phe Asp
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu 1850 1855 1860
Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His 1865
1870 1875 Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val
Gln 1880 1885 1890 Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr
Lys Ser Trp 1895 1900 1905 Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys
Arg Ala Pro Cys Asn 1910 1915 1920 Ile Gln Met Glu Asp Pro Thr Phe
Lys Glu Asn Tyr Arg Phe His 1925 1930 1935 Ala Ile Asn Gly Tyr Ile
Met Asp Thr Leu Pro Gly Leu Val Met 1940 1945 1950 Ala Gln Asp Gln
Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 1955 1960 1965 Asn Glu
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr 1970 1975 1980
Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 1985
1990 1995 Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala
Gly 2000 2005 2010 Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu
His Ala Gly 2015 2020 2025 Met Ser Thr Leu Phe Leu Val Tyr Ser Asn
Lys Cys Gln Thr Pro 2030 2035 2040 Leu Gly Met Ala Ser Gly His Ile
Arg Asp Phe Gln Ile Thr Ala 2045 2050 2055 Ser Gly Gln Tyr Gly Gln
Trp Ala Pro Lys Leu Ala Arg Leu His 2060 2065 2070 Tyr Ser Gly Ser
Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser 2075 2080 2085 Trp Ile
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 2090 2095 2100
Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 2105
2110 2115 Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln
Thr 2120 2125 2130 Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe
Phe Gly Asn 2135 2140 2145 Val Asp Ser Ser Gly Ile Lys His Asn Ile
Phe Asn Pro Pro Ile 2150 2155 2160 Ile Ala Arg Tyr Ile Arg Leu His
Pro Thr His Tyr Ser Ile Arg 2165 2170 2175 Ser Thr Leu Arg Met Glu
Leu Met Gly Cys Asp Leu Asn Ser Cys 2180 2185 2190 Ser Met Pro Leu
Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln 2195 2200 2205 Ile Thr
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser 2210 2215 2220
Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 2225
2230 2235 Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp
Phe 2240 2245 2250 Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln
Gly Val Lys 2255 2260 2265 Ser Leu Leu Thr Ser Met Tyr Val Lys Glu
Phe Leu Ile Ser Ser 2270 2275 2280 Ser Gln Asp Gly His Gln Trp Thr
Leu Phe Phe Gln Asn Gly Lys 2285 2290 2295 Val Lys Val Phe Gln Gly
Asn Gln Asp Ser Phe Thr Pro Val Val 2300 2305 2310 Asn Ser Leu Asp
Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 2315 2320 2325 Pro Gln
Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 2330 2335 2340
Gly Cys Glu Ala Gln Asp Leu Tyr 2345 2350 <210> SEQ ID NO 92
<211> LENGTH: 461 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct: FIX amino acid sequence
<400> SEQUENCE: 92 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly
Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val
Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn
Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg
Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr
Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210
215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro
Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys
Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala
His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly
Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg
Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala
Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu
Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330
335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala
Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met
Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys
Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly
Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys
Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg
Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 450 455 460
<210> SEQ ID NO 93 <211> LENGTH: 1384 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FIX DNA
sequence <400> SEQUENCE: 93 atgcagcgcg tgaacatgat catggcagaa
tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac tcagtgctga
atgtacagtt tttcttgatc atgaaaacgc acaaaattct 120 gaatcggcca
aagaggtata attcaggtaa attggaagag tttgttcaag ggaatctaga 180
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt ttgaaaacac
240 tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg
agtccaatcc 300 atgtttaaat ggcggcagtt gcaaggatga cattaattcc
tatgaatgtt ggtgtccctt 360 tggatttgaa ggaaagaact gtgaattaga
tgtaacatgt aacattaaga atggcagatg 420 cgagcagttt tgtaaaaata
gtgctgataa caaggtggtt tgctcctgta ctgagggata 480 tcgacttgca
gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 540
ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg atgtggacta
600 tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca
cccaatcatt 660 taatgacttc actcgggttg ttggtggaga agatgccaaa
ccaggtcaat tcccttggca 720 ggttgttttg aatggtaaag ttgatgcatt
ctgtggaggc tctatcgtta atgaaaaatg 780 gattgtaact gctgcccact
gtgttgaaac tggtgttaaa attacagttg tcgcaggtga 840 acataatatt
gaggagacag aacatacaga gcaaaagcga aatgtgattc gaattattcc 900
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc ttctggaact
960 ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg
acaaggaata 1020 cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt
ggctggggaa gagtcttcca 1080 caaagggaga tcagctttag ttcttcagta
ccttagagtt ccacttgttg accgagccac 1140 atgtcttcga tctacaaagt
tcaccatcta taacaacatg ttctgtgctg gcttccatga 1200 aggaggtaga
gattcatgtc aaggagatag tgggggaccc catgttactg aagtggaagg 1260
gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga aaggcaaata
1320 tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa
caaagctcac 1380 ttga 1384 <210> SEQ ID NO 94 <211>
LENGTH: 488 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FX amino acid sequence <400> SEQUENCE:
94 Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly
1 5 10 15 Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln
Ala Asn 20 25 30 Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe
Leu Glu Glu Met 35 40 45 Lys Lys Gly His Leu Glu Arg Glu Cys Met
Glu Glu Thr Cys Ser Tyr 50 55 60 Glu Glu Ala Arg Glu Val Phe Glu
Asp Ser Asp Lys Thr Asn Glu Phe 65 70 75 80 Trp Asn Lys Tyr Lys Asp
Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 85 90 95 Asn Gln Gly Lys
Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 100 105 110 Leu Glu
Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 115 120 125
Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 130
135 140 Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp
Asn 145 150 155 160 Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys
Gly Lys Gln Thr 165 170 175 Leu Glu Arg Arg Lys Arg Ser Val Ala Gln
Ala Thr Ser Ser Ser Gly 180 185 190 Glu Ala Pro Asp Ser Ile Thr Trp
Lys Pro Tyr Asp Ala Ala Asp Leu 195 200 205 Asp Pro Thr Glu Asn Pro
Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 210 215 220 Pro Glu Arg Gly
Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 225 230 235 240 Cys
Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 245 250
255 Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu
260 265 270 Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val
Arg Val 275 280 285 Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu
Ala Val His Glu 290 295 300 Val Glu Val Val Ile Lys His Asn Arg Phe
Thr Lys Glu Thr Tyr Asp 305 310 315 320 Phe Asp Ile Ala Val Leu Arg
Leu Lys Thr Pro Ile Thr Phe Arg Met 325 330 335 Asn Val Ala Pro Ala
Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 340 345 350 Leu Met Thr
Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 355 360 365 Glu
Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 370 375
380 Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln
385 390 395 400 Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp
Ala Cys Gln 405 410 415 Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe
Lys Asp Thr Tyr Phe 420 425 430 Val Thr Gly Ile Val Ser Trp Gly Glu
Gly Cys Ala Arg Lys Gly Lys 435 440 445 Tyr Gly Ile Tyr Thr Lys Val
Thr Ala Phe Leu Lys Trp Ile Asp Arg 450 455 460 Ser Met Lys Thr Arg
Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 465 470 475 480 Val Ile
Thr Ser Ser Pro Leu Lys 485 <210> SEQ ID NO 95 <211>
LENGTH: 1467 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FX DNA sequence <400> SEQUENCE: 95
atggggcgcc cactgcacct cgtcctgctc agtgcctccc tggctggcct cctgctgctc
60 ggggaaagtc tgttcatccg cagggagcag gccaacaaca tcctggcgag
ggtcacgagg 120 gccaattcct ttcttgaaga gatgaagaaa ggacacctcg
aaagagagtg catggaagag 180 acctgctcat acgaagaggc ccgcgaggtc
tttgaggaca gcgacaagac gaatgaattc 240 tggaataaat acaaagatgg
cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa 300 tgtaaagacg
gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac 360
tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc
420 cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct
ggctgacaac 480 ggcaaggcct gcattcccac agggccctac ccctgtggga
aacagaccct ggaacgcagg 540 aagaggtcag tggcccaggc caccagcagc
agcggggagg cccctgacag catcacatgg 600 aagccatatg atgcagccga
cctggacccc accgagaacc ccttcgacct gcttgacttc 660 aaccagacgc
agcctgagag gggcgacaac aacctcacca ggatcgtggg aggccaggaa 720
tgcaaggacg gggagtgtcc ctggcaggcc ctgctcatca atgaggaaaa cgagggtttc
780 tgtggtggaa ccattctgag cgagttctac atcctaacgg cagcccactg
tctctaccaa 840 gccaagagat tcaaggtgag ggtaggggac cggaacacgg
agcaggagga gggcggtgag 900 gcggtgcacg aggtggaggt ggtcatcaag
cacaaccggt tcacaaagga gacctatgac 960 ttcgacatcg ccgtgctccg
gctcaagacc cccatcacct tccgcatgaa cgtggcgcct 1020 gcctgcctcc
ccgagcgtga ctgggccgag tccacgctga tgacgcagaa gacggggatt 1080
gtgagcggct tcgggcgcac ccacgagaag ggccggcagt ccaccaggct caagatgctg
1140 gaggtgccct acgtggaccg caacagctgc aagctgtcca gcagcttcat
catcacccag 1200 aacatgttct gtgccggcta cgacaccaag caggaggatg
cctgccaggg ggacagcggg 1260 ggcccgcacg tcacccgctt caaggacacc
tacttcgtga caggcatcgt cagctgggga 1320 gagggctgtg cccgtaaggg
gaagtacggg atctacacca aggtcaccgc cttcctcaag 1380 tggatcgaca
ggtccatgaa aaccaggggc ttgcccaagg ccaagagcca tgccccggag 1440
gtcataacgt cctctccatt aaagtga 1467 <210> SEQ ID NO 96
<211> LENGTH: 3813 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence of FVII-066
<400> SEQUENCE: 96 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctggga
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtcga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaacggcgcc gccggagcgg tggcggcgga tcaggtgggg
gtggatcagg cggtggaggt 2160 tccggtggcg ggggatccgg cggtggaggt
tccggtgggg gtggatcaag gaagaggagg 2220 aagagggcgc aggtgcagct
gcaggagtct gggggaggct tggtacagcc tggggggtcc 2280 ctgagactct
cctgtgcagc ctctggattc atgtttagca ggtatgccat gagctgggtc 2340
cgccaggctc cagggaaggg gccagagtgg gtctcaggta ttagtggtag tggtggtagt
2400 acatactacg cagactccgt gaagggccgg ttcaccgtct ccagagacaa
ttccaagaac 2460 acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca
cggctgtata ttactgcgcc 2520 cggggcgcca cctacaccag ccggagcgac
gtgcccgacc agaccagctt cgactactgg 2580 ggccagggaa ccctggtcac
cgtctcctca gggagtgcat ccgccccaaa gcttgaagaa 2640 ggtgaatttt
cagaagcacg cgtatctgaa ctgactcagg accctgctgt gtctgtggcc 2700
ttgggacaga cagtcaggat cacatgccaa ggagacagcc tcagaaactt ttatgcaagc
2760 tggtaccagc agaagccagg acaggcccct actcttgtca tctatggttt
aagtaaaagg 2820 ccctcaggga tcccagaccg attctctgcc tccagctcag
gaaacacagc ttccttgacc 2880 atcactgggg ctcaggcgga agatgaggct
gactattact gcctgctgta ctacggcggc 2940 ggccagcagg gcgtgttcgg
cggcggcacc aagctgaccg tcctacgtca gcccaaggct 3000 gccccctcgg
tcactctgtt cccgccctct tctgcggccg gtggcggtgg ctccggcgga 3060
ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg ttccggtggc
3120 gggggatcag acaaaactca cacatgccca ccgtgcccag caccggaact
cctgggcgga 3180 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc
tcatgatctc ccggacccct 3240 gaggtcacat gcgtggtggt ggacgtgagc
cacgaagacc ctgaggtcaa gttcaactgg 3300 tacgtggacg gcgtggaggt
gcataatgcc aagacaaagc cgcgggagga gcagtacaac 3360 agcacgtacc
gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 3420
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc
3480 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc
ccgggatgag 3540 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag
gcttctatcc cagcgacatc 3600 gccgtggagt gggagagcaa tgggcagccg
gagaacaact acaagaccac gcctcccgtg 3660 ttggactccg acggctcctt
cttcctctac agcaagctca ccgtggacaa gagcaggtgg 3720 cagcagggga
acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 3780
cagaagagcc tctccctgtc tccgggtaaa tga 3813 <210> SEQ ID NO 97
<211> LENGTH: 1270 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-066 amino acid
sequence <400> SEQUENCE: 97 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg
690 695 700 Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 725 730 735 Arg Lys Arg Arg Lys Arg Ala Gln Val
Gln Leu Gln Glu Ser Gly Gly 740 745 750 Gly Leu Val Gln Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser 755 760 765 Gly Phe Met Phe Ser
Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 770 775 780 Gly Lys Gly
Pro Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Gly Ser 785 790 795 800
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp 805
810 815 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu 820 825 830 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr
Thr Ser Arg 835 840 845 Ser Asp Val Pro Asp Gln Thr Ser Phe Asp Tyr
Trp Gly Gln Gly Thr 850 855 860 Leu Val Thr Val Ser Ser Gly Ser Ala
Ser Ala Pro Lys Leu Glu Glu 865 870 875 880 Gly Glu Phe Ser Glu Ala
Arg Val Ser Glu Leu Thr Gln Asp Pro Ala 885 890 895 Val Ser Val Ala
Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 900 905 910 Ser Leu
Arg Asn Phe Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 915 920 925
Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser Lys Arg Pro Ser Gly Ile 930
935 940 Pro Asp Arg Phe Ser Ala Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr 945 950 955 960 Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Leu Leu 965 970 975 Tyr Tyr Gly Gly Gly Gln Gln Gly Val Phe
Gly Gly Gly Thr Lys Leu 980 985 990 Thr Val Leu Arg Gln Pro Lys Ala
Ala Pro Ser Val Thr Leu Phe Pro 995 1000 1005 Pro Ser Ser Ala Ala
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1010 1015 1020 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1025 1030 1035 Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1040 1045
1050 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
1055 1060 1065 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr 1070 1075 1080 Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe 1085 1090 1095 Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys 1100 1105 1110 Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val 1115 1120 1125 Leu Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 1130 1135 1140 Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 1145 1150 1155 Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 1160 1165
1170 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
1175 1180 1185 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu 1190 1195 1200 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro 1205 1210 1215 Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu 1220 1225 1230 Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 1235 1240 1245 Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser 1250 1255 1260 Leu Ser Leu
Ser Pro Gly Lys 1265 1270 <210> SEQ ID NO 98 <211>
LENGTH: 3012 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-057 <400>
SEQUENCE: 98 atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg
ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc
accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc
ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga
gatcttcaag gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg
atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300
gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag
360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga
gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg
aggggtactc tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa
tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc
ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc 600 ggtggcggcg
gatcaggtgg gggtggatca ggcggtggag gttccggtgg cgggggatcc 660
gacaaaactc acacatgccc accgtgccca gctccggaac tcctgggagg accgtcagtc
720 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc
tgaggtcaca 780 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca
agttcaactg gtacgtggac 840 ggcgtggagg tgcataatgc caagacaaag
ccgcgggagg agcagtacaa cagcacgtac 900 cgtgtggtca gcgtcctcac
cgtcctgcac caggactggc tgaatggcaa ggagtacaag 960 tgcaaggtct
ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1020
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag
1080 aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat
cgccgtggag 1140 tgggagagca atgggcagcc ggagaacaac tacaagacca
cgcctcccgt gttggactcc 1200 gacggctcct tcttcctcta cagcaagctc
accgtcgaca agagcaggtg gcagcagggg 1260 aacgtcttct catgctccgt
gatgcatgag gctctgcaca accactacac gcagaagagc 1320 ctctccctgt
ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 1380
ggttccggtg gcgggggatc cggcggtgga ggttccggtg ggggtggatc aggaggaggt
1440 ggttcaagcg tgagccagac cagcaagctg acccggattg tggggggcaa
ggtgtgcccc 1500 aaaggggagt gtccatggca ggtcctgttg ttggtgaatg
gagctcagtt gtgtgggggg 1560 accctgatca acaccatctg ggtggtctcc
gcggcccact gtttcgacaa aatcaagaac 1620 tggaggaacc tgatcgcggt
gctgggcgag cacgacctca gcgagcacga cggggatgag 1680 cagagccggc
gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac 1740
cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc
1800 ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg
cttctcattg 1860 gtcagcggct ggggccagct gctggaccgt ggcgccacgg
ccctggagct catggtcctc 1920 aacgtgcccc ggctgatgac ccaggactgc
ctgcagcagt cacggaaggt gggagactcc 1980 ccaaatatca cggagtacat
gttctgtgcc ggctactcgg atggcagcaa ggactcctgc 2040 aagggggaca
gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc 2100
atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc
2160 tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc
aggagtcctc 2220 ctgcgagccc catttcccgg tggcggtggc tccggcggag
gtgggtccgg tggcggcgga 2280 tcaggtgggg gtggatcagg cggtggaggt
tccggtggcg ggggatcaga caaaactcac 2340 acatgcccac cgtgcccagc
acctgaactc ctgggaggac cgtcagtctt cctcttcccc 2400 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 2460
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
2520 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 2580 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 2640 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg gcagccccga 2700 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 2760 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 2820
gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc
2880 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 2940 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012 <210> SEQ ID NO
99 <211> LENGTH: 1003 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-057 amino acid
sequence <400> SEQUENCE: 99 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Ser Val Ser Gln Thr Ser Lys Leu
Thr Arg Ile Val Gly Gly 485 490 495 Lys Val Cys Pro Lys Gly Glu Cys
Pro Trp Gln Val Leu Leu Leu Val 500 505 510 Asn Gly Ala Gln Leu Cys
Gly Gly Thr Leu Ile Asn Thr Ile Trp Val 515 520 525 Val Ser Ala Ala
His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530 535 540 Ile Ala
Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu 545 550 555
560 Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro
565 570 575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln
Pro Val 580 585 590 Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro
Glu Arg Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala Phe Val Arg Phe
Ser Leu Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu Asp Arg Gly Ala
Thr Ala Leu Glu Leu Met Val Leu 625 630 635 640 Asn Val Pro Arg Leu
Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650 655 Val Gly Asp
Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr 660 665 670 Ser
Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His 675 680
685 Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp
690 695 700 Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr
Arg Val 705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met
Arg Ser Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu Arg Ala Pro Phe
Pro Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Gly Gly
Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 770 775 780 Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 785 790 795 800
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 805
810 815 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn 820 825 830 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val 850 855 860 Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser 865 870 875 880 Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895 Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900 905 910 Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 915 920 925
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 930
935 940 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe 945 950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly 965 970 975 Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr 980 985 990 Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 995 1000 <210> SEQ ID NO 100 <211> LENGTH:
3012 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-058 <400>
SEQUENCE: 100 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 480 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg
ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc 600
ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg cgggggatcc
660 gacaaaactc acacatgccc accgtgccca gctccggaac tcctgggagg
accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct
cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag ccacgaagac
cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg tgcataatgc
caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900 cgtgtggtca
gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 960
tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa
1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga
gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa ggcttctatc
ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc ggagaacaac
tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct tcttcctcta
cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260 aacgtcttct
catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 1320
ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc aggcggtgga
1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg ggggtggatc
aggaggaggt 1440 ggttcagact tcctggccga gggcggcggc gtgcggattg
tggggggcaa ggtgtgcccc 1500 aaaggggagt gtccatggca ggtcctgttg
ttggtgaatg gagctcagtt gtgtgggggg 1560 accctgatca acaccatctg
ggtggtctcc gcggcccact gtttcgacaa aatcaagaac 1620 tggaggaacc
tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag 1680
cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac
1740 cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca
tgtggtgccc 1800 ctctgcctgc ccgaacggac gttctctgag aggacgctgg
ccttcgtgcg cttctcattg 1860 gtcagcggct ggggccagct gctggaccgt
ggcgccacgg ccctggagct catggtcctc 1920 aacgtgcccc ggctgatgac
ccaggactgc ctgcagcagt cacggaaggt gggagactcc 1980 ccaaatatca
cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc 2040
aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc
2100 atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta
caccagggtc 2160 tcccagtaca tcgagtggct gcaaaagctc atgcgctcag
agccacgccc aggagtcctc 2220 ctgcgagccc catttcccgg tggcggtggc
tccggcggag gtgggtccgg tggcggcgga 2280 tcaggtgggg gtggatcagg
cggtggaggt tccggtggcg ggggatcaga caaaactcac 2340 acatgcccac
cgtgcccagc acctgaactc ctgggaggac cgtcagtctt cctcttcccc 2400
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
2460 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 2520 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 2580 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 2640 aacaaagccc tcccagcccc
catcgagaaa accatctcca aagccaaagg gcagccccga 2700 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 2760
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat
2820 gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga
cggctccttc 2880 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 2940 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012
<210> SEQ ID NO 101 <211> LENGTH: 1003 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-058 amino acid sequence <400> SEQUENCE: 101 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Asp Phe Leu Ala
Glu Gly Gly Gly Val Arg Ile Val Gly Gly 485 490 495 Lys Val Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val 500 505 510 Asn Gly
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val 515 520 525
Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530
535 540 Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu 545 550 555 560 Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro 565 570 575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val 580 585 590 Val Leu Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu 625 630 635 640 Asn
Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650
655 Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr
660 665 670 Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro His 675 680 685 Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser Trp 690 695 700 Gly Gln Gly Cys Ala Thr Val Gly His Phe
Gly Val Tyr Thr Arg Val 705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 770 775
780 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
785 790 795 800 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr 805 810 815 Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn 820 825 830 Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val 850 855 860 Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 865 870 875 880 Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900
905 910 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe 915 920 925 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu 930 935 940 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe 945 950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly 965 970 975 Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr 980 985 990 Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 102
<211> LENGTH: 3003 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-059
<400> SEQUENCE: 102 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatcc 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggagg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg
ggggtggatc aggaggaggt 1440 ggttcaacca ccaagatcaa gccccggatt
gtggggggca aggtgtgccc caaaggggag 1500 tgtccatggc aggtcctgtt
gttggtgaat ggagctcagt tgtgtggggg gaccctgatc 1560 aacaccatct
gggtggtctc cgcggcccac tgtttcgaca aaatcaagaa ctggaggaac 1620
ctgatcgcgg tgctgggcga gcacgacctc agcgagcacg acggggatga gcagagccgg
1680 cgggtggcgc aggtcatcat ccccagcacg tacgtcccgg gcaccaccaa
ccacgacatc 1740 gcgctgctcc gcctgcacca gcccgtggtc ctcactgacc
atgtggtgcc cctctgcctg 1800 cccgaacgga cgttctctga gaggacgctg
gccttcgtgc gcttctcatt ggtcagcggc 1860 tggggccagc tgctggaccg
tggcgccacg gccctggagc tcatggtcct caacgtgccc 1920 cggctgatga
cccaggactg cctgcagcag tcacggaagg tgggagactc cccaaatatc 1980
acggagtaca tgttctgtgc cggctactcg gatggcagca aggactcctg caagggggac
2040 agtggaggcc cacatgccac ccactaccgg ggcacgtggt acctgacggg
catcgtcagc 2100 tggggccagg gctgcgcaac cgtgggccac tttggggtgt
acaccagggt ctcccagtac 2160 atcgagtggc tgcaaaagct catgcgctca
gagccacgcc caggagtcct cctgcgagcc 2220 ccatttcccg gtggcggtgg
ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg 2280 ggtggatcag
gcggtggagg ttccggtggc gggggatcag acaaaactca cacatgccca 2340
ccgtgcccag cacctgaact cctgggagga ccgtcagtct tcctcttccc cccaaaaccc
2400 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt
ggacgtgagc 2460 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg
gcgtggaggt gcataatgcc 2520 aagacaaagc cgcgggagga gcagtacaac
agcacgtacc gtgtggtcag cgtcctcacc 2580 gtcctgcacc aggactggct
gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 2640 ctcccagccc
ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 2700
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc
2760 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa
tgggcagccg 2820 gagaacaact acaagaccac gcctcccgtg ttggactccg
acggctcctt cttcctctac 2880 agcaagctca ccgtggacaa gagcaggtgg
cagcagggga acgtcttctc atgctccgtg 2940 atgcatgagg ctctgcacaa
ccactacacg cagaagagcc tctccctgtc tccgggtaaa 3000 tga 3003
<210> SEQ ID NO 103 <211> LENGTH: 1000 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-059 amino acid sequence <400> SEQUENCE: 103 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Thr Thr Lys Ile
Lys Pro Arg Ile Val Gly Gly Lys Val Cys 485 490 495 Pro Lys Gly Glu
Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala 500 505 510 Gln Leu
Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala 515 520 525
Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val 530
535 540 Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser
Arg 545 550 555 560 Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val
Pro Gly Thr Thr 565 570 575 Asn His Asp Ile Ala Leu Leu Arg Leu His
Gln Pro Val Val Leu Thr 580 585 590 Asp His Val Val Pro Leu Cys Leu
Pro Glu Arg Thr Phe Ser Glu Arg 595 600 605 Thr Leu Ala Phe Val Arg
Phe Ser Leu Val Ser Gly Trp Gly Gln Leu 610 615 620 Leu Asp Arg Gly
Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro 625 630 635 640 Arg
Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp 645 650
655 Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly
660 665 670 Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala
Thr His 675 680 685 Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser
Trp Gly Gln Gly 690 695 700 Cys Ala Thr Val Gly His Phe Gly Val Tyr
Thr Arg Val Ser Gln Tyr 705 710 715 720 Ile Glu Trp Leu Gln Lys Leu
Met Arg Ser Glu Pro Arg Pro Gly Val 725 730 735 Leu Leu Arg Ala Pro
Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775
780 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
785 790 795 800 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val 805 810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900
905 910 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser 915 920 925 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr 930 935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu Ser Leu
Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 104 <211>
LENGTH: 3012 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-060 <400>
SEQUENCE: 104 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 480 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg
ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc 600
ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg cgggggatcc
660 gacaaaactc acacatgccc accgtgccca gctccggaac tcctgggagg
accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct
cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag ccacgaagac
cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg tgcataatgc
caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900 cgtgtggtca
gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 960
tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa
1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga
gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa ggcttctatc
ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc ggagaacaac
tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct tcttcctcta
cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260 aacgtcttct
catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 1320
ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc aggcggtgga
1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg ggggtggatc
aggaggaggt 1440 ggttcagccc tgcggccccg ggtggtgggc ggcgccgtgg
tggggggcaa ggtgtgcccc 1500 aaaggggagt gtccatggca ggtcctgttg
ttggtgaatg gagctcagtt gtgtgggggg 1560 accctgatca acaccatctg
ggtggtctcc gcggcccact gtttcgacaa aatcaagaac 1620 tggaggaacc
tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag 1680
cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac
1740 cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca
tgtggtgccc 1800 ctctgcctgc ccgaacggac gttctctgag aggacgctgg
ccttcgtgcg cttctcattg 1860 gtcagcggct ggggccagct gctggaccgt
ggcgccacgg ccctggagct catggtcctc 1920 aacgtgcccc ggctgatgac
ccaggactgc ctgcagcagt cacggaaggt gggagactcc 1980 ccaaatatca
cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc 2040
aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc
2100 atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta
caccagggtc 2160 tcccagtaca tcgagtggct gcaaaagctc atgcgctcag
agccacgccc aggagtcctc 2220 ctgcgagccc catttcccgg tggcggtggc
tccggcggag gtgggtccgg tggcggcgga 2280 tcaggtgggg gtggatcagg
cggtggaggt tccggtggcg ggggatcaga caaaactcac 2340 acatgcccac
cgtgcccagc acctgaactc ctgggaggac cgtcagtctt cctcttcccc 2400
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
2460 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 2520 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 2580 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 2640 aacaaagccc tcccagcccc
catcgagaaa accatctcca aagccaaagg gcagccccga 2700 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 2760
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat
2820 gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga
cggctccttc 2880 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 2940 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012
<210> SEQ ID NO 105 <211> LENGTH: 1003 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-060 amino acid sequence <400> SEQUENCE: 105 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro
Arg Val Val Gly Gly Ala Val Val Gly Gly 485 490 495 Lys Val Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val 500 505 510 Asn Gly
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val 515 520 525
Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530
535 540 Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu 545 550 555 560 Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro 565 570 575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val 580 585 590 Val Leu Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu 625 630 635 640 Asn
Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650
655 Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr
660 665 670 Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro His 675 680 685 Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser Trp 690 695 700 Gly Gln Gly Cys Ala Thr Val Gly His Phe
Gly Val Tyr Thr Arg Val 705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 770 775
780 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
785 790 795 800 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr 805 810 815 Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn 820 825 830 Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val 850 855 860 Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 865 870 875 880 Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900
905 910 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe 915 920 925 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu 930 935 940 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe 945 950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly 965 970 975 Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr 980 985 990 Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 106
<211> LENGTH: 3012 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-061
<400> SEQUENCE: 106 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatcc 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggagg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg
ggggtggatc aggaggaggt 1440 ggttcagccc tgcggccccg ggtggtgggc
ggcgccattg tggggggcaa ggtgtgcccc 1500 aaaggggagt gtccatggca
ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg 1560 accctgatca
acaccatctg ggtggtctcc gcggcccact gtttcgacaa aatcaagaac 1620
tggaggaacc tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag
1680 cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg
caccaccaac 1740 cacgacatcg cgctgctccg cctgcaccag cccgtggtcc
tcactgacca tgtggtgccc 1800 ctctgcctgc ccgaacggac gttctctgag
aggacgctgg ccttcgtgcg cttctcattg 1860 gtcagcggct ggggccagct
gctggaccgt ggcgccacgg ccctggagct catggtcctc 1920 aacgtgcccc
ggctgatgac ccaggactgc ctgcagcagt cacggaaggt gggagactcc 1980
ccaaatatca cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc
2040 aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta
cctgacgggc 2100 atcgtcagct ggggccaggg ctgcgcaacc gtgggccact
ttggggtgta caccagggtc 2160 tcccagtaca tcgagtggct gcaaaagctc
atgcgctcag agccacgccc aggagtcctc 2220 ctgcgagccc catttcccgg
tggcggtggc tccggcggag gtgggtccgg tggcggcgga 2280 tcaggtgggg
gtggatcagg cggtggaggt tccggtggcg ggggatcaga caaaactcac 2340
acatgcccac cgtgcccagc acctgaactc ctgggaggac cgtcagtctt cctcttcccc
2400 ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg
cgtggtggtg 2460 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt
acgtggacgg cgtggaggtg 2520 cataatgcca agacaaagcc gcgggaggag
cagtacaaca gcacgtaccg tgtggtcagc 2580 gtcctcaccg tcctgcacca
ggactggctg aatggcaagg agtacaagtg caaggtctcc 2640 aacaaagccc
tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 2700
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc
2760 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg
ggagagcaat 2820 gggcagccgg agaacaacta caagaccacg cctcccgtgt
tggactccga cggctccttc 2880 ttcctctaca gcaagctcac cgtggacaag
agcaggtggc agcaggggaa cgtcttctca 2940 tgctccgtga tgcatgaggc
tctgcacaac cactacacgc agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012
<210> SEQ ID NO 107 <211> LENGTH: 1003 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-061 amino acid sequence <400> SEQUENCE: 107 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro
Arg Val Val Gly Gly Ala Ile Val Gly Gly 485 490 495 Lys Val Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val 500 505 510 Asn Gly
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val 515 520 525
Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530
535 540 Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu 545 550 555 560 Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro 565 570 575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val 580 585 590 Val Leu Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu 625 630 635 640 Asn
Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650
655 Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr
660 665 670 Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro His 675 680 685 Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser Trp 690 695 700 Gly Gln Gly Cys Ala Thr Val Gly His Phe
Gly Val Tyr Thr Arg Val 705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 770 775
780 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
785 790 795 800 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr 805 810 815 Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn 820 825 830 Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val 850 855 860 Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 865 870 875 880 Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900
905 910 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe 915 920 925 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu 930 935 940 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe 945 950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly 965 970 975 Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr 980 985 990 Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 108
<211> LENGTH: 2997 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-062
<400> SEQUENCE: 108 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatca 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggcgg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg
ggggtggatc aggaggaggt 1440 ggttcaggtg gtggaggatc cattgtgggg
ggcaaggtgt gccccaaagg ggagtgtcca 1500 tggcaggtcc tgttgttggt
gaatggagct cagttgtgtg gggggaccct gatcaacacc 1560 atctgggtgg
tctccgcggc ccactgtttc gacaaaatca agaactggag gaacctgatc 1620
gcggtgctgg gcgagcacga cctcagcgag cacgacgggg atgagcagag ccggcgggtg
1680 gcgcaggtca tcatccccag cacgtacgtc ccgggcacca ccaaccacga
catcgcgctg 1740 ctccgcctgc accagcccgt ggtcctcact gaccatgtgg
tgcccctctg cctgcccgaa 1800 cggacgttct ctgagaggac gctggccttc
gtgcgcttct cattggtcag cggctggggc 1860 cagctgctgg accgtggcgc
cacggccctg gagctcatgg tcctcaacgt gccccggctg 1920 atgacccagg
actgcctgca gcagtcacgg aaggtgggag actccccaaa tatcacggag 1980
tacatgttct gtgccggcta ctcggatggc agcaaggact cctgcaaggg ggacagtgga
2040 ggcccacatg ccacccacta ccggggcacg tggtacctga cgggcatcgt
cagctggggc 2100 cagggctgcg caaccgtggg ccactttggg gtgtacacca
gggtctccca gtacatcgag 2160 tggctgcaaa agctcatgcg ctcagagcca
cgcccaggag tcctcctgcg agccccattt 2220 cccggtggcg gtggctccgg
cggaggtggg tccggtggcg gcggatcagg tgggggtgga 2280 tcaggcggtg
gaggttccgg tggcggggga tcagacaaaa ctcacacatg cccaccgtgc 2340
ccagcacctg aactcctggg aggaccgtca gtcttcctct tccccccaaa acccaaggac
2400 accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt
gagccacgaa 2460 gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg
aggtgcataa tgccaagaca 2520 aagccgcggg aggagcagta caacagcacg
taccgtgtgg tcagcgtcct caccgtcctg 2580 caccaggact ggctgaatgg
caaggagtac aagtgcaagg tctccaacaa agccctccca 2640 gcccccatcg
agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 2700
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc
2760 aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca
gccggagaac 2820 aactacaaga ccacgcctcc cgtgttggac tccgacggct
ccttcttcct ctacagcaag 2880 ctcaccgtgg acaagagcag gtggcagcag
gggaacgtct tctcatgctc cgtgatgcat 2940 gaggctctgc acaaccacta
cacgcagaag agcctctccc tgtctccggg taaatga 2997 <210> SEQ ID NO
109 <211> LENGTH: 998 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-062 amino acid
sequence <400> SEQUENCE: 109 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly Ser Ile Val Gly
Gly Lys Val Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr Leu Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540 Glu His
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545 550 555
560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr
Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu Glu Leu
Met Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln Asp Cys
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650 655 Asn Ile Thr
Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 660 665 670 Asp
Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg 675 680
685 Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala
690 695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr
Ile Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg
Pro Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Asp Lys
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775 780 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 785 790 795 800
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 805
810 815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly 820 825 830 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895 Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900 905 910 Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 915 920 925
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 930
935 940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro Gly Lys 995
<210> SEQ ID NO 110 <211> LENGTH: 2997 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-090 <400> SEQUENCE: 110 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatca 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggcgg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcagccc
tgcggccccg gattgtgggg ggcaaggtgt gccccaaagg ggagtgtcca 1500
tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct gatcaacacc
1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca agaactggag
gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag cacgacgggg
atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag cacgtacgtc
ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc accagcccgt
ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800 cggacgttct
ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc 1860
cagctgctgg accgtggcgc cacggccctg gagctcatgg tcctcaacgt gccccggctg
1920 atgacccagg actgcctgca gcagtcacgg aaggtgggag actccccaaa
tatcacggag 1980 tacatgttct gtgccggcta ctcggatggc agcaaggact
cctgcaaggg ggacagtgga 2040 ggcccacatg ccacccacta ccggggcacg
tggtacctga cgggcatcgt cagctggggc 2100 cagggctgcg caaccgtggg
ccactttggg gtgtacacca gggtctccca gtacatcgag 2160 tggctgcaaa
agctcatgcg ctcagagcca cgcccaggag tcctcctgcg agccccattt 2220
cccggtggcg gtggctccgg cggaggtggg tccggtggcg gcggatcagg tgggggtgga
2280 tcaggcggtg gaggttccgg tggcggggga tcagacaaaa ctcacacatg
cccaccgtgc 2340 ccagcacctg aactcctggg aggaccgtca gtcttcctct
tccccccaaa acccaaggac 2400 accctcatga tctcccggac ccctgaggtc
acatgcgtgg tggtggacgt gagccacgaa 2460 gaccctgagg tcaagttcaa
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 2520 aagccgcggg
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 2580
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca
2640 gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc
acaggtgtac 2700 accctgcccc catcccggga tgagctgacc aagaaccagg
tcagcctgac ctgcctggtc 2760 aaaggcttct atcccagcga catcgccgtg
gagtgggaga gcaatgggca gccggagaac 2820 aactacaaga ccacgcctcc
cgtgttggac tccgacggct ccttcttcct ctacagcaag 2880 ctcaccgtgg
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2940
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga 2997
<210> SEQ ID NO 111 <211> LENGTH: 998 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-090 amino
acid sequence <400> SEQUENCE: 111 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly
Gly Lys Val Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr Leu Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540 Glu His
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545 550 555
560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr
Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu Glu Leu
Met Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln Asp Cys
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650 655 Asn Ile Thr
Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 660 665 670 Asp
Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg 675 680
685 Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala
690 695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr
Ile Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg
Pro Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Asp Lys
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775 780 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 785 790 795 800
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 805
810 815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly 820 825 830 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895 Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900 905 910 Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 915 920 925
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 930
935 940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro Gly Lys 995
<210> SEQ ID NO 112 <211> LENGTH: 2982 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-100 <400> SEQUENCE: 112 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatcc 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggagg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcagccc
tgcggccccg gattgtgggg ggcaaggtgt gccccaaagg ggagtgtcca 1500
tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct gatcaacacc
1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca agaactggag
gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag cacgacgggg
atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag cacgtacgtc
ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc accagcccgt
ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800 cggacgttct
ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc 1860
cagctgctgg accgtggcgc cacggccctg gagctcatgg tcctcaacgt gccccggctg
1920 atgacccagg actgcgaggc cagctacccc ggcaagatca cggagtacat
gttctgtgcc 1980 ggctactcgg atggcagcaa ggactcctgc aagggggaca
gtggaggccc acatgccacc 2040 cactaccggg gcacgtggta cctgacgggc
atcgtcagct ggggccaggg ctgcgcaacc 2100 gtgggccact ttggggtgta
caccagggtc tcccagtaca tcgagtggct gcaaaagctc 2160 atgcgctcag
agccacgccc aggagtcctc ctgcgagccc catttcccgg tggcggtggc 2220
tccggcggag gtgggtccgg tggcggcgga tcaggtgggg gtggatcagg cggtggaggt
2280 tccggtggcg ggggatcaga caaaactcac acatgcccac cgtgcccagc
acctgaactc 2340 ctgggaggac cgtcagtctt cctcttcccc ccaaaaccca
aggacaccct catgatctcc 2400 cggacccctg aggtcacatg cgtggtggtg
gacgtgagcc acgaagaccc tgaggtcaag 2460 ttcaactggt acgtggacgg
cgtggaggtg cataatgcca agacaaagcc gcgggaggag 2520 cagtacaaca
gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 2580
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa
2640 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct
gcccccatcc 2700 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc
tggtcaaagg cttctatccc 2760 agcgacatcg ccgtggagtg ggagagcaat
gggcagccgg agaacaacta caagaccacg 2820 cctcccgtgt tggactccga
cggctccttc ttcctctaca gcaagctcac cgtggacaag 2880 agcaggtggc
agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 2940
cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 2982 <210> SEQ
ID NO 113 <211> LENGTH: 993 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-100 amino acid
sequence <400> SEQUENCE: 113 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly
Gly Lys Val Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr Leu Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540 Glu His
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545 550 555
560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr
Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu Glu Leu
Met Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln Asp Cys
Glu Ala Ser Tyr Pro Gly Lys Ile Thr Glu Tyr 645 650 655 Met Phe Cys
Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly 660 665 670 Asp
Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu 675 680
685 Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe
690 695 700 Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln
Lys Leu 705 710 715 720 Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu
Arg Ala Pro Phe Pro 725 730 735 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys 755 760 765 Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 770 775 780 Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 785 790 795 800
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 805
810 815 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn 820 825 830 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val 835 840 845 Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu 850 855 860 Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys 865 870 875 880 Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 885 890 895 Leu Pro Pro Ser
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 900 905 910 Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 915 920 925
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 930
935 940 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys 945 950 955 960 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu 965 970 975 Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly 980 985 990 Lys <210> SEQ ID NO 114
<211> LENGTH: 2997 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-115
<400> SEQUENCE: 114 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatca 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggcgg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg
ggggtggatc aggaggaggt 1440 ggttcagccc tgcggccccg gattgtgggg
ggcaaggact gccccaaagg ggagtgtcca 1500 tggcaggtcc tgttgttggt
gaatggagct cagttgtgtg gggggaccct gatcaacacc 1560 atctgggtgg
tctccgcggc ccactgtttc gacaaaatca agaactggag gaacctgatc 1620
gcggtgctgg gcgagcacga cctcagcgag cacgacgggg atgagcagag ccggcgggtg
1680 gcgcaggtca tcatccccag cacgtacgtc ccgggcacca ccaaccacga
catcgcgctg 1740 ctccgcctgc accagcccgt ggtcctcact gaccatgtgg
tgcccctctg cctgcccgaa 1800 cggacgttct ctgagaggac gctggccttc
gtgcgcttct cattggtcag cggctggggc 1860 cagctgctgg accgtggcgc
cacggccctg gtactccaag tcctcaacgt gccccggctg 1920 atgacccagg
actgcctgca gcagtcacgg aaggtgggag actccccaaa tatcacggag 1980
tacatgttct gtgccggcta ctcggatggc agcaaggact cctgcaaggg ggacagtgga
2040 ggcccacatg ccacccacta ccggggcacg tggtacctga cgggcatcgt
cagctggggc 2100 cagggctgcg caaccgtggg ccactttggg gtgtacacca
gggtctccca gtacatcgag 2160 tggctgcaaa agctcatgcg ctcagagcca
cgcccaggag tcctcctgcg agccccattt 2220 cccggtggcg gtggctccgg
cggaggtggg tccggtggcg gcggatcagg tgggggtgga 2280 tcaggcggtg
gaggttccgg tggcggggga tcagacaaaa ctcacacatg cccaccgtgc 2340
ccagcacctg aactcctggg aggaccgtca gtcttcctct tccccccaaa acccaaggac
2400 accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt
gagccacgaa 2460 gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg
aggtgcataa tgccaagaca 2520 aagccgcggg aggagcagta caacagcacg
taccgtgtgg tcagcgtcct caccgtcctg 2580 caccaggact ggctgaatgg
caaggagtac aagtgcaagg tctccaacaa agccctccca 2640 gcccccatcg
agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 2700
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc
2760 aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca
gccggagaac 2820 aactacaaga ccacgcctcc cgtgttggac tccgacggct
ccttcttcct ctacagcaag 2880 ctcaccgtgg acaagagcag gtggcagcag
gggaacgtct tctcatgctc cgtgatgcat 2940 gaggctctgc acaaccacta
cacgcagaag agcctctccc tgtctccggg taaatga 2997 <210> SEQ ID NO
115 <211> LENGTH: 998 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-115 amino acid
sequence <400> SEQUENCE: 115 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly
Gly Lys Asp Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr Leu Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540 Glu His
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545 550 555
560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr
Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu Val Leu
Gln Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln Asp Cys
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650 655 Asn Ile Thr
Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 660 665 670 Asp
Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg 675 680
685 Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala
690 695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr
Ile Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg
Pro Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Asp Lys
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775 780 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 785 790 795 800
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 805
810 815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly 820 825 830 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895 Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900 905 910 Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 915 920 925
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 930
935 940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro Gly Lys 995
<210> SEQ ID NO 116 <211> LENGTH: 2859 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-118 <400> SEQUENCE: 116 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggcgcc ctgcggcccc
ggattgtggg gggcaaggtg 600 tgccccaaag gggagtgtcc atggcaggtc
ctgttgttgg tgaatggagc tcagttgtgt 660 ggggggaccc tgatcaacac
catctgggtg gtctccgcgg cccactgttt cgacaaaatc 720 aagaactgga
ggaacctgat cgcggtgctg ggcgagcacg acctcagcga gcacgacggg 780
gatgagcaga gccggcgggt ggcgcaggtc atcatcccca gcacgtacgt cccgggcacc
840 accaaccacg acatcgcgct gctccgcctg caccagcccg tggtcctcac
tgaccatgtg 900 gtgcccctct gcctgcccga acggacgttc tctgagagga
cgctggcctt cgtgcgcttc 960 tcattggtca gcggctgggg ccagctgctg
gaccgtggcg ccacggccct ggagctcatg 1020 gtcctcaacg tgccccggct
gatgacccag gactgcctgc agcagtcacg gaaggtggga 1080 gactccccaa
atatcacgga gtacatgttc tgtgccggct actcggatgg cagcaaggac 1140
tcctgcaagg gggacagtgg aggcccacat gccacccact accggggcac gtggtacctg
1200 acgggcatcg tcagctgggg ccagggctgc gcaaccgtgg gccactttgg
ggtgtacacc 1260 agggtctccc agtacatcga gtggctgcaa aagctcatgc
gctcagagcc acgcccagga 1320 gtcctcctgc gagccccatt tcccggtggc
ggtggctccg gcggaggtgg gtccggtggc 1380 ggcggatcag gtgggggtgg
atcaggcggt ggaggttccg gtggcggggg atccgacaaa 1440 actcacacat
gcccaccgtg cccagctccg gaactcctgg gcggaccgtc agtcttcctc 1500
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg
1560 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt
ggacggcgtg 1620 gaggtgcata atgccaagac aaagccgcgg gaggagcagt
acaacagcac gtaccgtgtg 1680 gtcagcgtcc tcaccgtcct gcaccaggac
tggctgaatg gcaaggagta caagtgcaag 1740 gtctccaaca aagccctccc
agcccccatc gagaaaacca tctccaaagc caaagggcag 1800 ccccgagaac
cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1860
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag
1920 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgttgga
ctccgacggc 1980 tccttcttcc tctacagcaa gctcaccgtg gacaagagca
ggtggcagca ggggaacgtc 2040 ttctcatgct ccgtgatgca tgaggctctg
cacaaccact acacgcagaa gagcctctcc 2100 ctgtctccgg gtaaaggtgg
cggcggatca ggtgggggtg gatcaggcgg tggaggttcc 2160 ggtggcgggg
gatcagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 2220
ggaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
2280 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 2340 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 2400 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 2460 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 2520 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc 2580
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc
2640 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 2700 cccgtgttgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 2760 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 2820 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 2859 <210> SEQ ID NO 117 <211>
LENGTH: 952 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-118 amino acid sequence <400>
SEQUENCE: 117 Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu
Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu
Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala
Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys
Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe
Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser
Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly
Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105
110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile
115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp
His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr
Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val
Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn
Ala Ser Lys Pro Gln Gly Ala Leu Arg 180 185 190 Pro Arg Ile Val Gly
Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp 195 200 205 Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu 210 215 220 Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile 225 230
235 240 Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu
Ser 245 250 255 Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln
Val Ile Ile 260 265 270 Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
Asp Ile Ala Leu Leu 275 280 285 Arg Leu His Gln Pro Val Val Leu Thr
Asp His Val Val Pro Leu Cys 290 295 300 Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu Ala Phe Val Arg Phe 305 310 315 320 Ser Leu Val Ser
Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala 325 330 335 Leu Glu
Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys 340 345 350
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr 355
360 365 Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys
Gly 370 375 380 Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr
Trp Tyr Leu 385 390 395 400 Thr Gly Ile Val Ser Trp Gly Gln Gly Cys
Ala Thr Val Gly His Phe 405 410 415 Gly Val Tyr Thr Arg Val Ser Gln
Tyr Ile Glu Trp Leu Gln Lys Leu 420 425 430 Met Arg Ser Glu Pro Arg
Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 435 440 445 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 465 470 475
480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600
605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 Lys Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720
Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 725
730 735 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro 740 745 750 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val 755 760 765 Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val 770 775 780 Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln 785 790 795 800 Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln 805 810 815 Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 820 825 830 Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 835 840 845
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 850
855 860 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser 865 870 875 880 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr 885 890 895 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr 900 905 910 Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 915 920 925 Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 930 935 940 Ser Leu Ser Leu
Ser Pro Gly Lys 945 950 <210> SEQ ID NO 118 <211>
LENGTH: 2874 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-119 <400>
SEQUENCE: 118 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 480 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg
ccagcaaacc ccaaggcgga ggaggtggtt cagccctgcg gccccggatt 600
gtggggggca aggtgtgccc caaaggggag tgtccatggc aggtcctgtt gttggtgaat
660 ggagctcagt tgtgtggggg gaccctgatc aacaccatct gggtggtctc
cgcggcccac 720 tgtttcgaca aaatcaagaa ctggaggaac ctgatcgcgg
tgctgggcga gcacgacctc 780 agcgagcacg acggggatga gcagagccgg
cgggtggcgc aggtcatcat ccccagcacg 840 tacgtcccgg gcaccaccaa
ccacgacatc gcgctgctcc gcctgcacca gcccgtggtc 900 ctcactgacc
atgtggtgcc cctctgcctg cccgaacgga cgttctctga gaggacgctg 960
gccttcgtgc gcttctcatt ggtcagcggc tggggccagc tgctggaccg tggcgccacg
1020 gccctggagc tcatggtcct caacgtgccc cggctgatga cccaggactg
cctgcagcag 1080 tcacggaagg tgggagactc cccaaatatc acggagtaca
tgttctgtgc cggctactcg 1140 gatggcagca aggactcctg caagggggac
agtggaggcc cacatgccac ccactaccgg 1200 ggcacgtggt acctgacggg
catcgtcagc tggggccagg gctgcgcaac cgtgggccac 1260 tttggggtgt
acaccagggt ctcccagtac atcgagtggc tgcaaaagct catgcgctca 1320
gagccacgcc caggagtcct cctgcgagcc ccatttcccg gtggcggtgg ctccggcgga
1380 ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg
ttccggtggc 1440 gggggatccg acaaaactca cacatgccca ccgtgcccag
ctccggaact cctgggcgga 1500 ccgtcagtct tcctcttccc cccaaaaccc
aaggacaccc tcatgatctc ccggacccct 1560 gaggtcacat gcgtggtggt
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 1620 tacgtggacg
gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 1680
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag
1740 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa
aaccatctcc 1800 aaagccaaag ggcagccccg agaaccacag gtgtacaccc
tgcccccatc ccgggatgag 1860 ctgaccaaga accaggtcag cctgacctgc
ctggtcaaag gcttctatcc cagcgacatc 1920 gccgtggagt gggagagcaa
tgggcagccg gagaacaact acaagaccac gcctcccgtg 1980 ttggactccg
acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 2040
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg
2100 cagaagagcc tctccctgtc tccgggtaaa ggtggcggcg gatcaggtgg
gggtggatca 2160 ggcggtggag gttccggtgg cgggggatca gacaaaactc
acacatgccc accgtgccca 2220 gcacctgaac tcctgggagg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 2280 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 2340 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 2400
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
2460 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 2520 cccatcgaga aaaccatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 2580 ctgcccccat cccgcgatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 2640 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 2700 tacaagacca
cgcctcccgt gttggactcc gacggctcct tcttcctcta cagcaagctc 2760
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
2820 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga
2874 <210> SEQ ID NO 119 <211> LENGTH: 957 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-119 amino acid sequence <400> SEQUENCE: 119 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Gly
Gly Gly 180 185 190 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly Gly Lys
Val Cys Pro Lys 195 200 205 Gly Glu Cys Pro Trp Gln Val Leu Leu Leu
Val Asn Gly Ala Gln Leu 210 215 220 Cys Gly Gly Thr Leu Ile Asn Thr
Ile Trp Val Val Ser Ala Ala His 225 230 235 240 Cys Phe Asp Lys Ile
Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 245 250 255 Glu His Asp
Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 260 265 270 Ala
Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His 275 280
285 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His
290 295 300 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg
Thr Leu 305 310 315 320 Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp
Gly Gln Leu Leu Asp 325 330 335 Arg Gly Ala Thr Ala Leu Glu Leu Met
Val Leu Asn Val Pro Arg Leu 340 345 350 Met Thr Gln Asp Cys Leu Gln
Gln Ser Arg Lys Val Gly Asp Ser Pro 355 360 365 Asn Ile Thr Glu Tyr
Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 370 375 380 Asp Ser Cys
Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg 385 390 395 400
Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala 405
410 415 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile
Glu 420 425 430 Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly
Val Leu Leu 435 440 445 Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 450 455 460 Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 465 470 475 480 Gly Gly Ser Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 485 490 495 Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 500 505 510 Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 515 520 525
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 530
535 540 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
Asn 545 550 555 560 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 565 570 575 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro 580 585 590 Ala Pro Ile Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro Arg Glu 595 600 605 Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 610 615 620 Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 625 630 635 640 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 645 650
655 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
660 665 670 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
Ser Cys 675 680 685 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
Gln Lys Ser Leu 690 695 700 Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 705 710 715 720 Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Asp Lys Thr His Thr Cys 725 730 735 Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 740 745 750 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 755 760 765 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 770 775
780 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
785 790 795 800 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 805 810 815 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys 820 825 830 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 835 840 845 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 850 855 860 Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 865 870 875 880 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 885 890 895
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 900
905 910 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 915 920 925 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 930 935 940 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 945 950 955 <210> SEQ ID NO 120 <211> LENGTH:
2844 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-127 <400>
SEQUENCE: 120 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 480 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg
ccagcaaacc ccaaggcgcc ctgcggcccc ggattgtggg gggcaaggtg 600
tgccccaaag gggagtgtcc atggcaggtc ctgttgttgg tgaatggagc tcagttgtgt
660 ggggggaccc tgatcaacac catctgggtg gtctccgcgg cccactgttt
cgacaaaatc 720 aagaactgga ggaacctgat cgcggtgctg ggcgagcacg
acctcagcga gcacgacggg 780 gatgagcaga gccggcgggt ggcgcaggtc
atcatcccca gcacgtacgt cccgggcacc 840 accaaccacg acatcgcgct
gctccgcctg caccagcccg tggtcctcac tgaccatgtg 900 gtgcccctct
gcctgcccga acggacgttc tctgagagga cgctggcctt cgtgcgcttc 960
tcattggtca gcggctgggg ccagctgctg gaccgtggcg ccacggccct ggagctcatg
1020 gtcctcaacg tgccccggct gatgacccag gactgcgagg ccagctaccc
cggcaagatc 1080 acggagtaca tgttctgtgc cggctactcg gatggcagca
aggactcctg caagggggac 1140 agtggaggcc cacatgccac ccactaccgg
ggcacgtggt acctgacggg catcgtcagc 1200 tggggccagg gctgcgcaac
cgtgggccac tttggggtgt acaccagggt ctcccagtac 1260 atcgagtggc
tgcaaaagct catgcgctca gagccacgcc caggagtcct cctgcgagcc 1320
ccatttcccg gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg
1380 ggtggatcag gcggtggagg ttccggtggc gggggatcag acaaaactca
cacatgccca 1440 ccgtgcccag ctccggaact cctgggcgga ccgtcagtct
tcctcttccc cccaaaaccc 1500 aaggacaccc tcatgatctc ccggacccct
gaggtcacat gcgtggtggt ggacgtgagc 1560 cacgaagacc ctgaggtcaa
gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1620 aagacaaagc
cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1680
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc
1740 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg
agaaccacag 1800 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga
accaggtcag cctgacctgc 1860 ctggtcaaag gcttctatcc cagcgacatc
gccgtggagt gggagagcaa tgggcagccg 1920 gagaacaact acaagaccac
gcctcccgtg ttggactccg acggctcctt cttcctctac 1980 agcaagctca
ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 2040
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa
2100 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatca 2160 gacaaaactc acacatgccc accgtgccca gcacctgaac
tcctgggagg accgtcagtc 2220 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 2280 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 2340 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 2400
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
2460 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 2520 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgcgatga gctgaccaag 2580 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 2640 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 2700 gacggctcct
tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 2760
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
2820 ctctccctgt ctccgggtaa atga 2844 <210> SEQ ID NO 121
<211> LENGTH: 947 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct: FVII-127 amino acid sequence
<400> SEQUENCE: 121 Met Val Ser Gln Ala Leu Arg Leu Leu Cys
Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val
Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg
Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu
Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg
Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80
Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85
90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu
Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp
Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr
Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His
Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr
Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu
Lys Arg Asn Ala Ser Lys Pro Gln Gly Ala Leu Arg 180 185 190 Pro Arg
Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp 195 200 205
Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu 210
215 220 Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys
Ile 225 230 235 240 Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu
His Asp Leu Ser 245 250 255 Glu His Asp Gly Asp Glu Gln Ser Arg Arg
Val Ala Gln Val Ile Ile 260 265 270 Pro Ser Thr Tyr Val Pro Gly Thr
Thr Asn His Asp Ile Ala Leu Leu 275 280 285 Arg Leu His Gln Pro Val
Val Leu Thr Asp His Val Val Pro Leu Cys 290 295 300 Leu Pro Glu Arg
Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe 305 310 315 320 Ser
Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala 325 330
335 Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys
340 345 350 Glu Ala Ser Tyr Pro Gly Lys Ile Thr Glu Tyr Met Phe Cys
Ala Gly 355 360 365 Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp
Ser Gly Gly Pro 370 375 380 His Ala Thr His Tyr Arg Gly Thr Trp Tyr
Leu Thr Gly Ile Val Ser 385 390 395 400 Trp Gly Gln Gly Cys Ala Thr
Val Gly His Phe Gly Val Tyr Thr Arg 405 410 415 Val Ser Gln Tyr Ile
Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro 420 425 430 Arg Pro Gly
Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser 435 440 445 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro
465 470 475 480 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
Phe Leu Phe 485 490 495 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu Val 500 505 510 Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys Phe 515 520 525 Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro 530 535 540 Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 545 550 555 560 Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 565 570 575
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 580
585 590 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg 595 600 605 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly 610 615 620 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro 625 630 635 640 Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser 645 650 655 Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 660 665 670 Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn His 675 680 685 Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 690 695 700
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705
710 715 720 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
Leu Gly 725 730 735 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp Thr Leu Met 740 745 750 Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp Val Ser His 755 760 765 Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu Val 770 775 780 His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 785 790 795 800 Arg Val Val
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 805 810 815 Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 820 825
830 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
835 840 845 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser 850 855 860 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu 865 870 875 880 Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro 885 890 895 Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val 900 905 910 Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 915 920 925 His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 930 935 940 Pro
Gly Lys 945 <210> SEQ ID NO 122 <211> LENGTH: 2169
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-125 <400> SEQUENCE: 122
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacatcgt gatgacccag 1440
gccgccccca gcgtgcccgt gacccccggc gagagcgtga gcatcagctg ccggagcagc
1500 cggagcctgc tgcacagcaa cggcaacacc tacctgtgct ggttcctgca
gcggcccggc 1560 cagagccccc agctgctgat ctaccggatg agcaacctgg
ccagcggcgt gcccgaccgg 1620 ttcagcggca gcggcagcgg caccgccttc
accctgcgga tcagccgggt ggaggccgag 1680 gacgtgggcg tgtactactg
catgcagcac ctggagtacc ccttcacctt cggcagcggc 1740 accaagctgg
agatcaagcg gggcggcggc ggcagcggcg gcggcggcag cggcggcggc 1800
ggcagccagg tgcagctgca gcagagcggc gccgagctgg tgcggcccgg caccagcgtg
1860 aagatcagct gcaaggccag cggctacacc ttcaccaact actggctggg
ctgggtgaag 1920 cagcggcccg gccacggcct ggagtggatc ggcgacatct
accccggcgg cggctacaac 1980 aagtacaacg agaacttcaa gggcaaggcc
accctgaccg ccgacaccag cagcagcacc 2040 gcctacatgc agctgagcag
cctgaccagc gaggacagcg ccgtgtactt ctgcgcccgg 2100 gagtacggca
actacgacta cgccatggac agctggggcc agggcaccag cgtgaccgtg 2160
agcagctga 2169 <210> SEQ ID NO 123 <211> LENGTH: 722
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-125 amino acid sequence <400> SEQUENCE: 123
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Ile Val 180 185 190 Gly Gly Lys Val Cys Pro Lys Gly Glu
Cys Pro Trp Gln Val Leu Leu 195 200 205 Leu Val Asn Gly Ala Gln Leu
Cys Gly Gly Thr Leu Ile Asn Thr Ile 210 215 220 Trp Val Val Ser Ala
Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 225 230 235 240 Asn Leu
Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 245 250 255
Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 260
265 270 Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His
Gln 275 280 285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu
Pro Glu Arg 290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg
Phe Ser Leu Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg
Gly Ala Thr Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg
Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly
Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr
Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380
Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385
390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val
Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu
Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro
Phe Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp Ile Val Met Thr Gln 465 470 475 480 Ala Ala Pro
Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser 485 490 495 Cys
Arg Ser Ser Arg Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu 500 505
510 Cys Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr
515 520 525 Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
Gly Ser 530 535 540 Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg
Val Glu Ala Glu 545 550 555 560 Asp Val Gly Val Tyr Tyr Cys Met Gln
His Leu Glu Tyr Pro Phe Thr 565 570 575 Phe Gly Ser Gly Thr Lys Leu
Glu Ile Lys Arg Gly Gly Gly Gly Ser 580 585 590 Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 595 600 605 Ser Gly Ala
Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile Ser Cys 610 615 620 Lys
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys 625 630
635 640 Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro
Gly 645 650 655 Gly Gly Tyr Asn Lys Tyr Asn Glu Asn Phe Lys Gly Lys
Ala Thr Leu 660 665 670 Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met
Gln Leu Ser Ser Leu 675 680 685 Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys Ala Arg Glu Tyr Gly Asn 690 695 700 Tyr Asp Tyr Ala Met Asp Ser
Trp Gly Gln Gly Thr Ser Val Thr Val 705 710 715 720 Ser Ser
<210> SEQ ID NO 124 <211> LENGTH: 3750 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-067 <400> SEQUENCE: 124 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg
gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg
aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt
ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg
cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780
cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac
840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt
gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg
tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc
acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga
ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt
acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140
gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc
1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag
ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac
gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg tggctccggc
ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat caggcggtgg
aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440 ccaccgtgcc
cagctccgga actcctgggc ggaccgtcag tcttcctctt ccccccaaaa 1500
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg
1560 agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga
ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac aacagcacgt
accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg gctgaatggc
aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag cccccatcga
gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800 caggtgtaca
ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 1860
tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag
1920 ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc
cttcttcctc 1980 tacagcaagc tcaccgtgga caagagcagg tggcagcagg
ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca caaccactac
acgcagaaga gcctctccct gtctccgggt 2100 aaaggtggcg gcggatcagg
tgggggtgga tcaggcggtg gaggttccgg tggcggggga 2160 tcagacaaaa
ctcacacatg cccaccgtgc ccagcacctg aactcctggg aggaccgtca 2220
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc
2280 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa
ctggtacgtg 2340 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg
aggagcagta caacagcacg 2400 taccgtgtgg tcagcgtcct caccgtcctg
caccaggact ggctgaatgg caaggagtac 2460 aagtgcaagg tctccaacaa
agccctccca gcccccatcg agaaaaccat ctccaaagcc 2520 aaagggcagc
cccgagaacc acaggtgtac accctgcccc catcccgcga tgagctgacc 2580
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg
2640 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc
cgtgttggac 2700 tccgacggct ccttcttcct ctacagcaag ctcaccgtcg
acaagagcag gtggcagcag 2760 gggaacgtct tctcatgctc cgtgatgcat
gaggctctgc acaaccacta cacgcagaag 2820 agcctctccc tgtctccggg
taaaggtggc ggtggctccg gcggaggtgg gtccggtggc 2880 ggcggatcag
gtgggggtgg atcaggcggt ggaggttccg gtggcggggg atcagcgcag 2940
gtgcagctgc aggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc
3000 tgtgcagcct ctggattcat gtttagcagg tatgccatga gctgggtccg
ccaggctcca 3060 gggaaggggc cagagtgggt ctcaggtatt agtggtagtg
gtggtagtac atactacgca 3120 gactccgtga agggccggtt caccgtctcc
agagacaatt ccaagaacac gctgtatctg 3180 caaatgaaca gcctgagagc
cgaggacacg gctgtatatt actgcgcccg gggcgccacc 3240 tacaccagcc
ggagcgacgt gcccgaccag accagcttcg actactgggg ccagggaacc 3300
ctggtcaccg tctcctcagg gagtgcatcc gccccaaagc ttgaagaagg tgaattttca
3360 gaagcacgcg tatctgaact gactcaggac cctgctgtgt ctgtggcctt
gggacagaca 3420 gtcaggatca catgccaagg agacagcctc agaaactttt
atgcaagctg gtaccagcag 3480 aagccaggac aggcccctac tcttgtcatc
tatggtttaa gtaaaaggcc ctcagggatc 3540 ccagaccgat tctctgcctc
cagctcagga aacacagctt ccttgaccat cactggggct 3600 caggcggaag
atgaggctga ctattactgc ctgctgtact acggcggcgg ccagcagggc 3660
gtgttcggcg gcggcaccaa gctgaccgtc ctacgtcagc ccaaggctgc cccctcggtc
3720 actctgttcc cgccctcttc tgcggcctga 3750 <210> SEQ ID NO
125 <211> LENGTH: 1249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-067 amino acid
sequence <400> SEQUENCE: 125 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805
810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930
935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 965 970 975 Gly Ser Ala Gln Val Gln Leu Gln Glu Ser
Gly Gly Gly Leu Val Gln 980 985 990 Pro Gly Gly Ser Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Met Phe 995 1000 1005 Ser Arg Tyr Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 1010 1015 1020 Pro Glu Trp
Val Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr 1025 1030 1035 Tyr
Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 1040 1045
1050 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
1055 1060 1065 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr
Thr Ser 1070 1075 1080 Arg Ser Asp Val Pro Asp Gln Thr Ser Phe Asp
Tyr Trp Gly Gln 1085 1090 1095 Gly Thr Leu Val Thr Val Ser Ser Gly
Ser Ala Ser Ala Pro Lys 1100 1105 1110 Leu Glu Glu Gly Glu Phe Ser
Glu Ala Arg Val Ser Glu Leu Thr 1115 1120 1125 Gln Asp Pro Ala Val
Ser Val Ala Leu Gly Gln Thr Val Arg Ile 1130 1135 1140 Thr Cys Gln
Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser Trp Tyr 1145 1150 1155 Gln
Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu 1160 1165
1170 Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser
1175 1180 1185 Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln
Ala Glu 1190 1195 1200 Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr
Gly Gly Gly Gln 1205 1210 1215 Gln Gly Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Arg Gln 1220 1225 1230 Pro Lys Ala Ala Pro Ser Val
Thr Leu Phe Pro Pro Ser Ser Ala 1235 1240 1245 Ala <210> SEQ
ID NO 126 <211> LENGTH: 2244 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: DNA sequence
for FVII-094 <400> SEQUENCE: 126 atggtctccc aggccctcag
gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg
taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120
gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc
180 tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct
gttctggatt 240 tcttacagtg atggggacca gtgtgcctca agtccatgcc
agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc
ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct
gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca
cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca 480
gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa
540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg
ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc
agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc
cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg
cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg
cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac 840
atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc
900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc
attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg
agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag
cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg
tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag
gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200
agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag
1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt
cctcctgcga 1320 gccccatttc ccgatatcgg tggcggtggc tccggcggag
gtgggtccgg tggcggcgga 1380 tcaggtgggg gtggatcagg cggtggaggt
tccggtggcg ggggatcagc gcaggtgcag 1440 ctgcaggagt ctgggggagg
cttggtacag cctggggggt ccctgagact ctcctgtgca 1500 gcctctggat
tcatgtttag caggtatgcc atgagctggg tccgccaggc tccagggaag 1560
gggccagagt gggtctcagg tattagtggt agtggtggta gtacatacta cgcagactcc
1620 gtgaagggcc ggttcaccgt ctccagagac aattccaaga acacgctgta
tctgcaaatg 1680 aacagcctga gagccgagga cacggctgta tattactgcg
cccggggcgc cacctacacc 1740 agccggagcg acgtgcccga ccagaccagc
ttcgactact ggggccaggg aaccctggtc 1800 accgtctcct cagggagtgc
atccgcccca aagcttgaag aaggtgaatt ttcagaagca 1860 cgcgtatctg
aactgactca ggaccctgct gtgtctgtgg ccttgggaca gacagtcagg 1920
atcacatgcc aaggagacag cctcagaaac ttttatgcaa gctggtacca gcagaagcca
1980 ggacaggccc ctactcttgt catctatggt ttaagtaaaa ggccctcagg
gatcccagac 2040 cgattctctg cctccagctc aggaaacaca gcttccttga
ccatcactgg ggctcaggcg 2100 gaagatgagg ctgactatta ctgcctgctg
tactacggcg gcggccagca gggcgtgttc 2160 ggcggcggca ccaagctgac
cgtcctacgt cagcccaagg ctgccccctc ggtcactctg 2220 ttcccgccct
cttctgcggc ctga 2244 <210> SEQ ID NO 127 <211> LENGTH:
747 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-094 amino acid sequence <400> SEQUENCE: 127
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Ile Val 180 185 190 Gly Gly Lys Val Cys Pro Lys Gly Glu
Cys Pro Trp Gln Val Leu Leu 195 200 205 Leu Val Asn Gly Ala Gln Leu
Cys Gly Gly Thr Leu Ile Asn Thr Ile 210 215 220 Trp Val Val Ser Ala
Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 225 230 235 240 Asn Leu
Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 245 250 255
Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 260
265 270 Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His
Gln 275 280 285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu
Pro Glu Arg 290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg
Phe Ser Leu Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg
Gly Ala Thr Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg
Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly
Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr
Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380
Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385
390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val
Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu
Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro
Phe Pro Asp Ile Gly Gly 435 440 445 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 450 455 460 Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ala Gln Val Gln 465 470 475 480 Leu Gln Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 485 490 495 Leu
Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Arg Tyr Ala Met Ser 500 505
510 Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile
515 520 525 Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
Gly Arg 530 535 540 Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr Leu Gln Met 545 550 555 560 Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Gly 565 570 575 Ala Thr Tyr Thr Ser Arg Ser
Asp Val Pro Asp Gln Thr Ser Phe Asp 580 585 590 Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser 595 600 605 Ala Pro Lys
Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Glu 610 615 620 Leu
Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 625 630
635 640 Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser Trp
Tyr 645 650 655 Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr
Gly Leu Ser 660 665 670 Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
Ala Ser Ser Ser Gly 675 680 685 Asn Thr Ala Ser Leu Thr Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala 690 695 700 Asp Tyr Tyr Cys Leu Leu Tyr
Tyr Gly Gly Gly Gln Gln Gly Val Phe 705 710 715 720 Gly Gly Gly Thr
Lys Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro 725 730 735 Ser Val
Thr Leu Phe Pro Pro Ser Ser Ala Ala 740 745 <210> SEQ ID NO
128 <211> LENGTH: 3507 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-028
<400> SEQUENCE: 128 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcggaagtgc agctggtgca
gtctggagct gaggtgaata agcctggggc ctcagtgaag 120 gtctcctgca
aggcttctgg atacaccttc accggctact atatgcactg ggtgcgacag 180
gcccctggac aagggcttga gtggatggga tggatcaacc ctaacagtgg tggcacaaac
240 tatgcacaga agtttcaggg ctgggtcacc atgaccaggg acacgtccat
cagcaccgcc 300 tacatggagc tgagcaggct gagatctgac gacacggccg
tgtattactg tgcgagaggc 360 cgtgctttgt ataaccggaa cgaccggtcc
cccaactggt tcgacccctg gggccaggga 420 accctggtca ccgtctcctc
agggagtgca tccgccccaa cccttaaact tgaagaaggt 480 gaattttcag
aagcacgcgt acaggctgtg ctgactcagc cgccctcggt gtcagtggcc 540
ccaggacaga cggccaggat tacctgtggg ggaaacaaca ttggaagtaa aagtgtgcag
600 tggtaccagc agaagccagg ccaggcccct gtgctggtcg tctatgatga
tagcgaccgg 660 ccctcaggga tccctgagcg attctctggc tccaactctg
ggaacatggc caccctgacc 720 atcagcaggg tcgaagccgg ggatgaggcc
gactattact gtcaggtgtg ggatagtagt 780 agtgatcatg tggtattcgg
cggagggacc aagctgaccg tcctaggtca gcccaaggct 840 gccccctcgg
tcactctgtt cccgccgtcc gcggccgcta ggacgaagct gttctggatt 900
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
960 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 1020 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 1080 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 1140 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 1200 aaaagaaatg
ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg 1260
gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg ggggaccctg
1320 atcaacacca tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa
gaactggagg 1380 aacctgatcg cggtgctggg cgagcacgac ctcagcgagc
acgacgggga tgagcagagc 1440 cggcgggtgg cgcaggtcat catccccagc
acgtacgtcc cgggcaccac caaccacgac 1500 atcgcgctgc tccgcctgca
ccagcccgtg gtcctcactg accatgtggt gcccctctgc 1560 ctgcccgaac
ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc 1620
ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt cctcaacgtg
1680 ccccggctga tgacccagga ctgcctgcag cagtcacgga aggtgggaga
ctccccaaat 1740 atcacggagt acatgttctg tgccggctac tcggatggca
gcaaggactc ctgcaagggg 1800 gacagtggag gcccacatgc cacccactac
cggggcacgt ggtacctgac gggcatcgtc 1860 agctggggcc agggctgcgc
aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1920 tacatcgagt
ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga 1980
gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg cggatcaggt
2040 gggggtggat caggcggtgg aggttccggt ggcgggggat ccgacaaaac
tcacacatgc 2100 ccaccgtgcc cagctccgga actcctgggc ggaccgtcag
tcttcctctt ccccccaaaa 2160 cccaaggaca ccctcatgat ctcccggacc
cctgaggtca catgcgtggt ggtggacgtg 2220 agccacgaag accctgaggt
caagttcaac tggtacgtgg acggcgtgga ggtgcataat 2280 gccaagacaa
agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 2340
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa
2400 gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc
ccgagaacca 2460 caggtgtaca ccctgccccc atcccgggat gagctgacca
agaaccaggt cagcctgacc 2520 tgcctggtca aaggcttcta tcccagcgac
atcgccgtgg agtgggagag caatgggcag 2580 ccggagaaca actacaagac
cacgcctccc gtgttggact ccgacggctc cttcttcctc 2640 tacagcaagc
tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2700
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt
2760 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg gaggttccgg
tggcggggga 2820 tccgacaaaa ctcacacatg cccaccgtgc ccagcacctg
aactcctggg aggaccgtca 2880 gtcttcctct tccccccaaa acccaaggac
accctcatga tctcccggac ccctgaggtc 2940 acatgcgtgg tggtggacgt
gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 3000 gacggcgtgg
aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 3060
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac
3120 aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat
ctccaaagcc 3180 aaagggcagc cccgagaacc acaggtgtac accctgcccc
catcccgcga tgagctgacc 3240 aagaaccagg tcagcctgac ctgcctggtc
aaaggcttct atcccagcga catcgccgtg 3300 gagtgggaga gcaatgggca
gccggagaac aactacaaga ccacgcctcc cgtgttggac 3360 tccgacggct
ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 3420
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag
3480 agcctctccc tgtctccggg taaatga 3507 <210> SEQ ID NO 129
<211> LENGTH: 1168 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-028 amino acid
sequence <400> SEQUENCE: 129 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Glu
Val Gln Leu Val Gln Ser Gly Ala Glu Val 20 25 30 Asn Lys Pro Gly
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 35 40 45 Thr Phe
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 50 55 60
Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 65
70 75 80 Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp
Thr Ser 85 90 95 Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
Ser Asp Asp Thr 100 105 110 Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala
Leu Tyr Asn Arg Asn Asp 115 120 125 Arg Ser Pro Asn Trp Phe Asp Pro
Trp Gly Gln Gly Thr Leu Val Thr 130 135 140 Val Ser Ser Gly Ser Ala
Ser Ala Pro Thr Leu Lys Leu Glu Glu Gly 145 150 155 160 Glu Phe Ser
Glu Ala Arg Val Gln Ala Val Leu Thr Gln Pro Pro Ser 165 170 175 Val
Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 180 185
190 Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln
195 200 205 Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser
Gly Ile 210 215 220 Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met
Ala Thr Leu Thr 225 230 235 240 Ile Ser Arg Val Glu Ala Gly Asp Glu
Ala Asp Tyr Tyr Cys Gln Val 245 250 255 Trp Asp Ser Ser Ser Asp His
Val Val Phe Gly Gly Gly Thr Lys Leu 260 265 270 Thr Val Leu Gly Gln
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 275 280 285 Pro Ser Ala
Ala Ala Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp 290 295 300 Gly
Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys 305 310
315 320 Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu
Gly 325 330 335 Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys
Val Asn Glu 340 345 350 Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His
Thr Gly Thr Lys Arg 355 360 365 Ser Cys Arg Cys His Glu Gly Tyr Ser
Leu Leu Ala Asp Gly Val Ser 370 375 380 Cys Thr Pro Thr Val Glu Tyr
Pro Cys Gly Lys Ile Pro Ile Leu Glu 385 390 395 400 Lys Arg Asn Ala
Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val 405 410 415 Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly 420 425 430
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser 435
440 445 Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala 450 455 460 Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu Gln Ser 465 470 475 480 Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro Gly Thr 485 490 495 Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val Val Leu 500 505 510 Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu 515 520 525 Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln 530 535 540 Leu Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val 545 550 555
560 Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly
565 570 575 Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr
Ser Asp 580 585 590 Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro His Ala Thr 595 600 605 His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser Trp Gly Gln 610 615 620 Gly Cys Ala Thr Val Gly His Phe
Gly Val Tyr Thr Arg Val Ser Gln 625 630 635 640 Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly 645 650 655 Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly 660 665 670 Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 675 680
685 Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
690 695 700 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys 705 710 715 720 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val 725 730 735 Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr 740 745 750 Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu 755 760 765 Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His 770 775 780 Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 785 790 795 800
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 805
810 815 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu 820 825 830 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro 835 840 845 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn 850 855 860 Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu 865 870 875 880 Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 885 890 895 Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 900 905 910 Lys Ser
Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 915 920 925
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 930
935 940 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser 945 950 955 960 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg 965 970 975 Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro 980 985 990 Glu Val Lys Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala 995 1000 1005 Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 1010 1015 1020 Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 1025 1030 1035 Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 1040 1045
1050 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
1055 1060 1065 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
Asn Gln 1070 1075 1080 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 1085 1090 1095 Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys 1100 1105 1110 Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr 1115 1120 1125 Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 1130 1135 1140 Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 1145 1150 1155 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 1160 1165 <210> SEQ ID NO
130 <211> LENGTH: 2868 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence FVII-039
<400> SEQUENCE: 130 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggcggaggag acttcactcg ggttgtgggg
600 ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt
gaatggagct 660 cagttgtgtg gggggaccct gatcaacacc atctgggtgg
tctccgcggc ccactgtttc 720 gacaaaatca agaactggag gaacctgatc
gcggtgctgg gcgagcacga cctcagcgag 780 cacgacgggg atgagcagag
ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc 840 ccgggcacca
ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact 900
gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc
960 gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc
cacggccctg 1020 gagctcatgg tcctcaacgt gccccggctg atgacccagg
actgcctgca gcagtcacgg 1080 aaggtgggag actccccaaa tatcacggag
tacatgttct gtgccggcta ctcggatggc 1140 agcaaggact cctgcaaggg
ggacagtgga ggcccacatg ccacccacta ccggggcacg 1200 tggtacctga
cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg 1260
gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca
1320 cgcccaggag tcctcctgcg agccccattt cccggtggcg gtggctccgg
cggaggtggg 1380 tccggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 1440 tccgacaaaa ctcacacatg cccaccgtgc
ccagctccgg aactcctggg cggaccgtca 1500 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 1560 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 1620
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
1680 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 1740 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 1800 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccggga tgagctgacc 1860 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1920 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 1980
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag
2040 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2100 agcctctccc tgtctccggg taaaggtggc ggcggatcag
gtgggggtgg atcaggcggt 2160 ggaggttccg gtggcggggg atcagacaaa
actcacacat gcccaccgtg cccagcacct 2220 gaactcctgg gaggaccgtc
agtcttcctc ttccccccaa aacccaagga caccctcatg 2280 atctcccgga
cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 2340
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg
2400 gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct
gcaccaggac 2460 tggctgaatg gcaaggagta caagtgcaag gtctccaaca
aagccctccc agcccccatc 2520 gagaaaacca tctccaaagc caaagggcag
ccccgagaac cacaggtgta caccctgccc 2580 ccatcccgcg atgagctgac
caagaaccag gtcagcctga cctgcctggt caaaggcttc 2640 tatcccagcg
acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 2700
accacgcctc ccgtgttgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg
2760 gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca
tgaggctctg 2820 cacaaccact acacgcagaa gagcctctcc ctgtctccgg
gtaaatga 2868 <210> SEQ ID NO 131 <211> LENGTH: 955
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-039 amino acid sequence <400> SEQUENCE: 131
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Gly Gly 180 185 190 Gly Asp Phe Thr Arg Val Val Gly Gly
Lys Val Cys Pro Lys Gly Glu 195 200 205 Cys Pro Trp Gln Val Leu Leu
Leu Val Asn Gly Ala Gln Leu Cys Gly 210 215 220 Gly Thr Leu Ile Asn
Thr Ile Trp Val Val Ser Ala Ala His Cys Phe 225 230 235 240 Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His 245 250 255
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln 260
265 270 Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp
Ile 275 280 285 Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp
His Val Val 290 295 300 Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu
Arg Thr Leu Ala Phe 305 310 315 320 Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp Arg Gly 325 330 335 Ala Thr Ala Leu Glu Leu
Met Val Leu Asn Val Pro Arg Leu Met Thr 340 345 350 Gln Asp Cys Leu
Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile 355 360 365 Thr Glu
Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser 370 375 380
Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr 385
390 395 400 Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala
Thr Val 405 410 415 Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr
Ile Glu Trp Leu 420 425 430 Gln Lys Leu Met Arg Ser Glu Pro Arg Pro
Gly Val Leu Leu Arg Ala 435 440 445 Pro Phe Pro Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 450 455 460 Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470 475 480 Ser Asp Lys
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 485 490 495 Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 500 505
510 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
515 520 525 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu 530 535 540 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr 545 550 555 560 Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn 565 570 575 Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro 580 585 590 Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 595 600 605 Val Tyr Thr
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 610 615 620 Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 625 630
635 640 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro 645 650 655 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr 660 665 670 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val 675 680 685 Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu 690 695 700 Ser Pro Gly Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 705 710 715 720 Gly Gly Ser Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 725 730 735 Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 740 745 750
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 755
760 765 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn 770 775 780 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg 785 790 795 800 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val 805 810 815 Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser 820 825 830 Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 835 840 845 Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 850 855 860 Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 865 870 875
880 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
885 890 895 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe 900 905 910 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly 915 920 925 Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr 930 935 940 Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 945 950 955 <210> SEQ ID NO 132 <211>
LENGTH: 2865 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-040 <400>
SEQUENCE: 132 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 480 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540 aaaagaaatg
ccagcaaacc ccaaggcggc ggaggagact tcactcgggt tgtggggggc 600
aaggtgtgcc ccaaagggga gtgtccatgg caggtcctgt tgttggtgaa tggagctcag
660 ttgtgtgggg ggaccctgat caacaccatc tgggtggtct ccgcggccca
ctgtttcgac 720 aaaatcaaga actggaggaa cctgatcgcg gtgctgggcg
agcacgacct cagcgagcac 780 gacggggatg agcagagccg gcgggtggcg
caggtcatca tccccagcac gtacgtcccg 840 ggcaccacca accacgacat
cgcgctgctc cgcctgcacc agcccgtggt cctcactgac 900 catgtggtgc
ccctctgcct gcccgaacgg acgttctctg agaggacgct ggccttcgtg 960
cgcttctcat tggtcagcgg ctggggccag ctgctggacc gtggcgccac ggccctggag
1020 ctcatggtcc tcaacgtgcc ccggctgatg acccaggact gcctgcagca
gtcacggaag 1080 gtgggagact ccccaaatat cacggagtac atgttctgtg
ccggctactc ggatggcagc 1140 aaggactcct gcaaggggga cagtggaggc
ccacatgcca cccactaccg gggcacgtgg 1200 tacctgacgg gcatcgtcag
ctggggccag ggctgcgcaa ccgtgggcca ctttggggtg 1260 tacaccaggg
tctcccagta catcgagtgg ctgcaaaagc tcatgcgctc agagccacgc 1320
ccaggagtcc tcctgcgagc cccatttccc ggtggcggtg gctccggcgg aggtgggtcc
1380 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatcc 1440 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggcgg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
1740 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1860 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1980 gacggctcct
tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 2040
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
2100 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 2160 ggttccggtg gcgggggatc agacaaaact cacacatgcc
caccgtgccc agcacctgaa 2220 ctcctgggag gaccgtcagt cttcctcttc
cccccaaaac ccaaggacac cctcatgatc 2280 tcccggaccc ctgaggtcac
atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 2340 aagttcaact
ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 2400
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg
2460 ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc
ccccatcgag 2520 aaaaccatct ccaaagccaa agggcagccc cgagaaccac
aggtgtacac cctgccccca 2580 tcccgcgatg agctgaccaa gaaccaggtc
agcctgacct gcctggtcaa aggcttctat 2640 cccagcgaca tcgccgtgga
gtgggagagc aatgggcagc cggagaacaa ctacaagacc 2700 acgcctcccg
tgttggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 2760
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac
2820 aaccactaca cgcagaagag cctctccctg tctccgggta aatga 2865
<210> SEQ ID NO 133 <211> LENGTH: 954 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-040 amino
acid sequence <400> SEQUENCE: 133 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Gly Gly Gly 180 185
190 Asp Phe Thr Arg Val Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys
195 200 205 Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys
Gly Gly 210 215 220 Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala
His Cys Phe Asp 225 230 235 240 Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala Val Leu Gly Glu His Asp 245 250 255 Leu Ser Glu His Asp Gly Asp
Glu Gln Ser Arg Arg Val Ala Gln Val 260 265 270 Ile Ile Pro Ser Thr
Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala 275 280 285 Leu Leu Arg
Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro 290 295 300 Leu
Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val 305 310
315 320 Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly
Ala 325 330 335 Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu
Met Thr Gln 340 345 350 Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp
Ser Pro Asn Ile Thr 355 360 365 Glu Tyr Met Phe Cys Ala Gly Tyr Ser
Asp Gly Ser Lys Asp Ser Cys 370 375 380 Lys Gly Asp Ser Gly Gly Pro
His Ala Thr His Tyr Arg Gly Thr Trp 385 390 395 400 Tyr Leu Thr Gly
Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly 405 410 415 His Phe
Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln 420 425 430
Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro 435
440 445 Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555
560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
565 570 575 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 610 615 620 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680
685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
690 695 700 Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly 705 710 715 720 Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His
Thr Cys Pro Pro Cys 725 730 735 Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro 740 745 750 Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys 755 760 765 Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 770 775 780 Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 785 790 795 800
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 805
810 815 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 820 825 830 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 835 840 845 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu 850 855 860 Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr 865 870 875 880 Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 885 890 895 Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 900 905 910 Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 915 920 925
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 930
935 940 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 945 950 <210>
SEQ ID NO 134 <211> LENGTH: 3107 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: DNA sequence
for FIX-042 <400> SEQUENCE: 134 atgcagcgcg tgaacatgat
catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac
tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat
180 gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa
gtactgtggg 240 aacatcacag attttggctc catgccctaa agagaaattg
gctttcagat tatttggatt 300 aaaaacaaag actttcttaa gagatgtaaa
attttcatga tgttttcttt tttgctaaaa 360 ctaaagaatt attcttttac
atttcagttt ttcttgatca tgaaaacgcc aacaaaattc 420 tgaatcggcc
aaagaggtat aattcaggta aattggaaga gtttgttcaa gggaatctag 480
agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt tttgaaaaca
540 ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt
gagtccaatc 600 catgtttaaa tggcggcagt tgcaaggatg acattaattc
ctatgaatgt tggtgtccct 660 ttggatttga aggaaagaac tgtgaattag
atgtaacatg taacattaag aatggcagat 720 gcgagcagtt ttgtaaaaat
agtgctgata acaaggtggt ttgctcctgt actgagggat 780 atcgacttgc
agaaaaccag aagtcctgtg aaccagcagt gccatttcca tgtggaagag 840
tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct gatgtggact
900 atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc
acccaatcat 960 ttaatgactt cactcgggtt gttggtggag aagatgccaa
accaggtcaa ttcccttggc 1020 aggttgtttt gaatggtaaa gttgatgcat
tctgtggagg ctctatcgtt aatgaaaaat 1080 ggattgtaac tgctgcccac
tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg 1140 aacataatat
tgaggagaca gaacatacag agcaaaagcg aaatgtgatt cgaattattc 1200
ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc cttctggaac
1260 tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct
gacaaggaat 1320 acacgaacat cttcctcaaa tttggatctg gctatgtaag
tggctgggga agagtcttcc 1380 acaaagggag atcagcttta gttcttcagt
accttagagt tccacttgtt gaccgagcca 1440 catgtcttcg atctacaaag
ttcaccatct ataacaacat gttctgtgct ggcttccatg 1500 aaggaggtag
agattcatgt caaggagata gtgggggacc ccatgttact gaagtggaag 1560
ggaccagttt cttaactgga attattagct ggggtgaaga gtgtgcaatg aaaggcaaat
1620 atggaatata taccaaggtg tcccggtatg tcaactggat taaggaaaaa
acaaagctca 1680 ctgacaaaac tcacacatgc ccaccgtgcc cagctccgga
actcctgggc ggaccgtcag 1740 tcttcctctt ccccccaaaa cccaaggaca
ccctcatgat ctcccggacc cctgaggtca 1800 catgcgtggt ggtggacgtg
agccacgaag accctgaggt caagttcaac tggtacgtgg 1860 acggcgtgga
ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt 1920
accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca
1980 agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc
tccaaagcca 2040 aagggcagcc ccgagaacca caggtgtaca ccctgccccc
atcccgggat gagctgacca 2100 agaaccaggt cagcctgacc tgcctggtca
aaggcttcta tcccagcgac atcgccgtgg 2160 agtgggagag caatgggcag
ccggagaaca actacaagac cacgcctccc gtgttggact 2220 ccgacggctc
cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg 2280
ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga
2340 gcctctccct gtctccgggt aaaggtggcg gcggatcagg tgggggtgga
tcaggcggtg 2400 gaggttccgg tggcggggga tcagacaaaa ctcacacatg
cccaccgtgc ccagcacctg 2460 aactcctggg aggaccgtca gtcttcctct
tccccccaaa acccaaggac accctcatga 2520 tctcccggac ccctgaggtc
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg 2580 tcaagttcaa
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg 2640
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact
2700 ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca
gcccccatcg 2760 agaaaaccat ctccaaagcc aaagggcagc cccgagaacc
acaggtgtac accctgcccc 2820 catcccgcga tgagctgacc aagaaccagg
tcagcctgac ctgcctggtc aaaggcttct 2880 atcccagcga catcgccgtg
gagtgggaga gcaatgggca gccggagaac aactacaaga 2940 ccacgcctcc
cgtgttggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg 3000
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc
3060 acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga 3107
<210> SEQ ID NO 135 <211> LENGTH: 935 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FIX-042 amino
acid sequence <400> SEQUENCE: 135 Met Gln Arg Val Asn Met Ile
Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly
Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu
Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser
Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55
60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys
Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly
Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile
Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp
Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu
Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro
Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185
190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
Asp Phe 210 215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly
Gln Phe Pro Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp
Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val
Thr Ala Ala His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val
Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu
Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr
Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310
315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys
Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly
Arg Ser Ala Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val
Asp Arg Ala Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr
Asn Asn Met Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg
Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu
Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435
440 445 Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys
Thr 450 455 460 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser 465 470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555
560 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
565 570 575 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu 580 585 590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys 595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680
685 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
690 695 700 Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro 705 710 715 720 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 725 730 735 Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val 740 745 750 Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp 755 760 765 Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 770 775 780 Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 785 790 795 800
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 805
810 815 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg 820 825 830 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr Lys 835 840 845 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp 850 855 860 Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys 865 870 875 880 Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 885 890 895 Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 900 905 910 Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 915 920 925
Leu Ser Leu Ser Pro Gly Lys 930 935 <210> SEQ ID NO 136
<211> LENGTH: 4073 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FIX-068
<400> SEQUENCE: 136 atgcagcgcg tgaacatgat catggcagaa
tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac tcagtgctga
atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120 gcttgccttt
tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg
240 aacatcacag attttggctc catgccctaa agagaaattg gctttcagat
tatttggatt 300 aaaaacaaag actttcttaa gagatgtaaa attttcatga
tgttttcttt tttgctaaaa 360 ctaaagaatt attcttttac atttcagttt
ttcttgatca tgaaaacgcc aacaaaattc 420 tgaatcggcc aaagaggtat
aattcaggta aattggaaga gtttgttcaa gggaatctag 480 agagagaatg
tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt tttgaaaaca 540
ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt gagtccaatc
600 catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt
tggtgtccct 660 ttggatttga aggaaagaac tgtgaattag atgtaacatg
taacattaag aatggcagat 720 gcgagcagtt ttgtaaaaat agtgctgata
acaaggtggt ttgctcctgt actgagggat 780 atcgacttgc agaaaaccag
aagtcctgtg aaccagcagt gccatttcca tgtggaagag 840 tttctgtttc
acaaacttct aagctcaccc gtgctgagac tgtttttcct gatgtggact 900
atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc acccaatcat
960 ttaatgactt cactcgggtt gttggtggag aagatgccaa accaggtcaa
ttcccttggc 1020 aggttgtttt gaatggtaaa gttgatgcat tctgtggagg
ctctatcgtt aatgaaaaat 1080 ggattgtaac tgctgcccac tgtgttgaaa
ctggtgttaa aattacagtt gtcgcaggtg 1140 aacataatat tgaggagaca
gaacatacag agcaaaagcg aaatgtgatt cgaattattc 1200 ctcaccacaa
ctacaatgca gctattaata agtacaacca tgacattgcc cttctggaac 1260
tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct gacaaggaat
1320 acacgaacat cttcctcaaa tttggatctg gctatgtaag tggctgggga
agagtcttcc 1380 acaaagggag atcagcttta gttcttcagt accttagagt
tccacttgtt gaccgagcca 1440 catgtcttcg atctacaaag ttcaccatct
ataacaacat gttctgtgct ggcttccatg 1500 aaggaggtag agattcatgt
caaggagata gtgggggacc ccatgttact gaagtggaag 1560 ggaccagttt
cttaactgga attattagct ggggtgaaga gtgtgcaatg aaaggcaaat 1620
atggaatata taccaaggtg tcccggtatg tcaactggat taaggaaaaa acaaagctca
1680 ctgacaaaac tcacacatgc ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag 1740 tcttcctctt ccccccaaaa cccaaggaca ccctcatgat
ctcccggacc cctgaggtca 1800 catgcgtggt ggtggacgtg agccacgaag
accctgaggt caagttcaac tggtacgtgg 1860 acggcgtgga ggtgcataat
gccaagacaa agccgcggga ggagcagtac aacagcacgt 1920 accgtgtggt
cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca 1980
agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca
2040 aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat
gagctgacca 2100 agaaccaggt cagcctgacc tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg 2160 agtgggagag caatgggcag ccggagaaca
actacaagac cacgcctccc gtgttggact 2220 ccgacggctc cttcttcctc
tacagcaagc tcaccgtcga caagagcagg tggcagcagg 2280 ggaacgtctt
ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga 2340
gcctctccct gtctccgggt aaacggcgcc gccggagcgg tggcggcgga tcaggtgggg
2400 gtggatcagg cggtggaggt tccggtggcg ggggatccgg cggtggaggt
tccggtgggg 2460 gtggatcaag gaagaggagg aagagggcgc aggtgcagct
gcaggagtct gggggaggct 2520 tggtacagcc tggggggtcc ctgagactct
cctgtgcagc ctctggattc atgtttagca 2580 ggtatgccat gagctgggtc
cgccaggctc cagggaaggg gccagagtgg gtctcaggta 2640 ttagtggtag
tggtggtagt acatactacg cagactccgt gaagggccgg ttcaccgtct 2700
ccagagacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca
2760 cggctgtata ttactgcgcc cggggcgcca cctacaccag ccggagcgac
gtgcccgacc 2820 agaccagctt cgactactgg ggccagggaa ccctggtcac
cgtctcctca gggagtgcat 2880 ccgccccaaa gcttgaagaa ggtgaatttt
cagaagcacg cgtatctgaa ctgactcagg 2940 accctgctgt gtctgtggcc
ttgggacaga cagtcaggat cacatgccaa ggagacagcc 3000 tcagaaactt
ttatgcaagc tggtaccagc agaagccagg acaggcccct actcttgtca 3060
tctatggttt aagtaaaagg ccctcaggga tcccagaccg attctctgcc tccagctcag
3120 gaaacacagc ttccttgacc atcactgggg ctcaggcgga agatgaggct
gactattact 3180 gcctgctgta ctacggcggc ggccagcagg gcgtgttcgg
cggcggcacc aagctgaccg 3240 tcctacgtca gcccaaggct gccccctcgg
tcactctgtt cccgccctct tctgcggccg 3300 gtggcggtgg ctccggcgga
ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag 3360 gcggtggagg
ttccggtggc gggggatcag acaaaactca cacatgccca ccgtgcccag 3420
caccggaact cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc
3480 tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
cacgaagacc 3540 ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc aagacaaagc 3600 cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc gtcctgcacc 3660 aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc 3720 ccatcgagaa
aaccatctcc aaagccaaag ggcagccccg agaaccacag gtgtacaccc 3780
tgcccccatc ccgcgatgag ctgaccaaga accaggtcag cctgacctgc ctggtcaaag
3840 gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
gagaacaact 3900 acaagaccac gcctcccgtg ttggactccg acggctcctt
cttcctctac agcaagctca 3960 ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg atgcatgagg 4020 ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaaa tga 4073 <210> SEQ ID NO 137
<211> LENGTH: 1257 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FIX-068 amino acid sequence
<400> SEQUENCE: 137 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly
Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val
Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn
Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg
Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr
Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210
215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro
Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys
Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala
His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly
Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg
Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala
Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu
Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330
335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala
Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met
Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys
Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly
Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys
Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg
Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 450 455
460 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
465 470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555 560 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 565 570 575
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 580
585 590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys 595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680 685 Arg Arg
Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 690 695 700
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 705
710 715 720 Gly Gly Ser Arg Lys Arg Arg Lys Arg Ala Gln Val Gln Leu
Gln Glu 725 730 735 Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
Arg Leu Ser Cys 740 745 750 Ala Ala Ser Gly Phe Met Phe Ser Arg Tyr
Ala Met Ser Trp Val Arg 755 760 765 Gln Ala Pro Gly Lys Gly Pro Glu
Trp Val Ser Gly Ile Ser Gly Ser 770 775 780 Gly Gly Ser Thr Tyr Tyr
Ala Asp Ser Val Lys Gly Arg Phe Thr Val 785 790 795 800 Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 805 810 815 Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr 820 825
830 Thr Ser Arg Ser Asp Val Pro Asp Gln Thr Ser Phe Asp Tyr Trp Gly
835 840 845 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala
Pro Lys 850 855 860 Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser
Glu Leu Thr Gln 865 870 875 880 Asp Pro Ala Val Ser Val Ala Leu Gly
Gln Thr Val Arg Ile Thr Cys 885 890 895 Gln Gly Asp Ser Leu Arg Asn
Phe Tyr Ala Ser Trp Tyr Gln Gln Lys 900 905 910 Pro Gly Gln Ala Pro
Thr Leu Val Ile Tyr Gly Leu Ser Lys Arg Pro 915 920 925 Ser Gly Ile
Pro Asp Arg Phe Ser Ala Ser Ser Ser Gly Asn Thr Ala 930 935 940 Ser
Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 945 950
955 960 Cys Leu Leu Tyr Tyr Gly Gly Gly Gln Gln Gly Val Phe Gly Gly
Gly 965 970 975 Thr Lys Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro
Ser Val Thr 980 985 990 Leu Phe Pro Pro Ser Ser Ala Ala Gly Gly Gly
Gly Ser Gly Gly Gly 995 1000 1005 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 1010 1015 1020 Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr His Thr Cys Pro Pro 1025 1030 1035 Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 1040 1045 1050 Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 1055 1060 1065
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 1070
1075 1080 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys 1085 1090 1095 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val 1100 1105 1110 Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu 1115 1120 1125 Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu 1130 1135 1140 Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val 1145 1150 1155 Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 1160 1165 1170 Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 1175 1180 1185
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 1190
1195 1200 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser 1205 1210 1215 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe 1220 1225 1230 Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln 1235 1240 1245 Lys Ser Leu Ser Leu Ser Pro Gly
Lys 1250 1255 <210> SEQ ID NO 138 <211> LENGTH: 4010
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FIX-088 <400> SEQUENCE: 138
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta
60 ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata
cattgagtat 120 gcttgccttt tagatataga aatatctgat gctgtcttct
tcactaaatt ttgattacat 180 gatttgacag caatattgaa gagtctaaca
gccagcacgc aggttggtaa gtactgtggg 240 aacatcacag attttggctc
catgccctaa agagaaattg gctttcagat tatttggatt 300 aaaaacaaag
actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa 360
ctaaagaatt attcttttac atttcagttt ttcttgatca tgaaaacgcc aacaaaattc
420 tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa
gggaatctag 480 agagagaatg tatggaagaa aagtgtagtt ttgaagaagc
acgagaagtt tttgaaaaca 540 ctgaaagaac aactgaattt tggaagcagt
atgttgatgg agatcagtgt gagtccaatc 600 catgtttaaa tggcggcagt
tgcaaggatg acattaattc ctatgaatgt tggtgtccct 660 ttggatttga
aggaaagaac tgtgaattag atgtaacatg taacattaag aatggcagat 720
gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt actgagggat
780 atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca
tgtggaagag 840 tttctgtttc acaaacttct aagctcaccc gtgctgagac
tgtttttcct gatgtggact 900 atgtaaattc tactgaagct gaaaccattt
tggataacat cactcaaagc acccaatcat 960 ttaatgactt cactcgggtt
gttggtggag aagatgccaa accaggtcaa ttcccttggc 1020 aggttgtttt
gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat 1080
ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg
1140 aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt
cgaattattc 1200 ctcaccacaa ctacaatgca gctattaata agtacaacca
tgacattgcc cttctggaac 1260 tggacgaacc cttagtgcta aacagctacg
ttacacctat ttgcattgct gacaaggaat 1320 acacgaacat cttcctcaaa
tttggatctg gctatgtaag tggctgggga agagtcttcc 1380 acaaagggag
atcagcttta gttcttcagt accttagagt tccacttgtt gaccgagcca 1440
catgtcttcg atctacaaag ttcaccatct ataacaacat gttctgtgct ggcttccatg
1500 aaggaggtag agattcatgt caaggagata gtgggggacc ccatgttact
gaagtggaag 1560 ggaccagttt cttaactgga attattagct ggggtgaaga
gtgtgcaatg aaaggcaaat 1620 atggaatata taccaaggtg tcccggtatg
tcaactggat taaggaaaaa acaaagctca 1680 ctgacaaaac tcacacatgc
ccaccgtgcc cagctccgga actcctgggc ggaccgtcag 1740 tcttcctctt
ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca 1800
catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg
1860 acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac
aacagcacgt 1920 accgtgtggt cagcgtcctc accgtcctgc accaggactg
gctgaatggc aaggagtaca 1980 agtgcaaggt ctccaacaaa gccctcccag
cccccatcga gaaaaccatc tccaaagcca 2040 aagggcagcc ccgagaacca
caggtgtaca ccctgccccc atcccgggat gagctgacca 2100 agaaccaggt
cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg 2160
agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgttggact
2220 ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg
tggcagcagg 2280 ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca
caaccactac acgcagaaga 2340 gcctctccct gtctccgggt aaaggtggcg
gcggatcagg tgggggtgga tcaggcggtg 2400 gaggttccgg tggcggggga
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg 2460 aactcctggg
aggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga 2520
tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg
2580 tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca
aagccgcggg 2640 aggagcagta caacagcacg taccgtgtgg tcagcgtcct
caccgtcctg caccaggact 2700 ggctgaatgg caaggagtac aagtgcaagg
tctccaacaa agccctccca gcccccatcg 2760 agaaaaccat ctccaaagcc
aaagggcagc cccgagaacc acaggtgtac accctgcccc 2820 catcccgcga
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct 2880
atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga
2940 ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag
ctcaccgtcg 3000 acaagagcag gtggcagcag gggaacgtct tctcatgctc
cgtgatgcat gaggctctgc 3060 acaaccacta cacgcagaag agcctctccc
tgtctccggg taaaggtggc ggtggctccg 3120 gcggaggtgg gtccggtggc
ggcggatcag gtgggggtgg atcaggcggt ggaggttccg 3180 gtggcggggg
atcagcgcag gtgcagctgc aggagtctgg gggaggcttg gtacagcctg 3240
gggggtccct gagactctcc tgtgcagcct ctggattcat gtttagcagg tatgccatga
3300 gctgggtccg ccaggctcca gggaaggggc cagagtgggt ctcaggtatt
agtggtagtg 3360 gtggtagtac atactacgca gactccgtga agggccggtt
caccgtctcc agagacaatt 3420 ccaagaacac gctgtatctg caaatgaaca
gcctgagagc cgaggacacg gctgtatatt 3480 actgcgcccg gggcgccacc
tacaccagcc ggagcgacgt gcccgaccag accagcttcg 3540 actactgggg
ccagggaacc ctggtcaccg tctcctcagg gagtgcatcc gccccaaagc 3600
ttgaagaagg tgaattttca gaagcacgcg tatctgaact gactcaggac cctgctgtgt
3660 ctgtggcctt gggacagaca gtcaggatca catgccaagg agacagcctc
agaaactttt 3720 atgcaagctg gtaccagcag aagccaggac aggcccctac
tcttgtcatc tatggtttaa 3780 gtaaaaggcc ctcagggatc ccagaccgat
tctctgcctc cagctcagga aacacagctt 3840 ccttgaccat cactggggct
caggcggaag atgaggctga ctattactgc ctgctgtact 3900 acggcggcgg
ccagcagggc gtgttcggcg gcggcaccaa gctgaccgtc ctacgtcagc 3960
ccaaggctgc cccctcggtc actctgttcc cgccctcttc tgcggcctga 4010
<210> SEQ ID NO 139 <211> LENGTH: 1236 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FIX-088 amino acid sequence <400> SEQUENCE: 139 Met Gln Arg
Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile
Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25
30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu
Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln
Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn
Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp
Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val
Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys
Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155
160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser
Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr
Gln Ser Phe Asn Asp Phe 210 215 220 Thr Arg Val Val Gly Gly Glu Asp
Ala Lys Pro Gly Gln Phe Pro Trp 225 230 235 240 Gln Val Val Leu Asn
Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val Asn Glu
Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 260 265 270 Val
Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 275 280
285 His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
290 295 300 Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
Leu Glu 305 310 315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val
Thr Pro Ile Cys Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe
Leu Lys Phe Gly Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly Arg Val
Phe His Lys Gly Arg Ser Ala Leu Val 355 360 365 Leu Gln Tyr Leu Arg
Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 370 375 380 Ser Thr Lys
Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 385 390 395 400
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 405
410 415 Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp
Gly 420 425 430 Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
Lys Val Ser 435 440 445 Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys
Leu Thr Asp Lys Thr 450 455 460 His Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser 465 470 475 480 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 485 490 495 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 500 505 510 Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 515 520 525
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 530
535 540 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr 545 550 555 560 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 565 570 575 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 580 585 590 Pro Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys 595 600 605 Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 610 615 620 Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 625 630 635 640 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 645 650
655 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
660 665 670 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 675 680 685 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Lys Thr His Thr Cys
Pro Pro Cys Pro Ala Pro 705 710 715 720 Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys 725 730 735 Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 740 745 750 Asp Val Ser
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 755 760 765 Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 770 775
780 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
785 790 795 800 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu 805 810 815 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg 820 825 830 Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys 835 840 845 Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp 850 855 860 Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 865 870 875 880 Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 885 890 895
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 900
905 910 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser 915 920 925 Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly
Gly Gly Gly 930 935 940 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 945 950 955 960 Gly Gly Gly Gly Ser Ala Gln Val
Gln Leu Gln Glu Ser Gly Gly Gly 965 970 975 Leu Val Gln Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 980 985 990 Phe Met Phe Ser
Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 995 1000 1005 Lys
Gly Pro Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Gly Ser 1010 1015
1020 Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg
1025 1030 1035 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
Leu Arg 1040 1045 1050 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
Gly Ala Thr Tyr 1055 1060 1065 Thr Ser Arg Ser Asp Val Pro Asp Gln
Thr Ser Phe Asp Tyr Trp 1070 1075 1080 Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Ser Ala Ser Ala 1085 1090 1095 Pro Lys Leu Glu Glu
Gly Glu Phe Ser Glu Ala Arg Val Ser Glu 1100 1105 1110 Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val 1115 1120 1125 Arg
Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser 1130 1135
1140 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr
1145 1150 1155 Gly Leu Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe
Ser Ala 1160 1165 1170 Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile
Thr Gly Ala Gln 1175 1180 1185 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Leu Leu Tyr Tyr Gly Gly 1190 1195 1200 Gly Gln Gln Gly Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu 1205 1210 1215 Arg Gln Pro Lys Ala
Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 1220 1225 1230 Ser Ala Ala
1235 <210> SEQ ID NO 140 <211> LENGTH: 3263 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FIX-089 <400> SEQUENCE: 140 atgcagcgcg
tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat
120 gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt
ttgattacat 180 gatttgacag caatattgaa gagtctaaca gccagcacgc
aggttggtaa gtactgtggg 240 aacatcacag attttggctc catgccctaa
agagaaattg gctttcagat tatttggatt 300 aaaaacaaag actttcttaa
gagatgtaaa attttcatga tgttttcttt tttgctaaaa 360 ctaaagaatt
attcttttac atttcagttt ttcttgatca tgaaaacgcc aacaaaattc 420
tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa gggaatctag
480 agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt
tttgaaaaca 540 ctgaaagaac aactgaattt tggaagcagt atgttgatgg
agatcagtgt gagtccaatc 600 catgtttaaa tggcggcagt tgcaaggatg
acattaattc ctatgaatgt tggtgtccct 660 ttggatttga aggaaagaac
tgtgaattag atgtaacatg taacattaag aatggcagat 720 gcgagcagtt
ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt actgagggat 780
atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca tgtggaagag
840 tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct
gatgtggact 900 atgtaaattc tactgaagct gaaaccattt tggataacat
cactcaaagc acccaatcat 960 ttaatgactt cactcgggtt gttggtggag
aagatgccaa accaggtcaa ttcccttggc 1020 aggttgtttt gaatggtaaa
gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat 1080 ggattgtaac
tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg 1140
aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt cgaattattc
1200 ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc
cttctggaac 1260 tggacgaacc cttagtgcta aacagctacg ttacacctat
ttgcattgct gacaaggaat 1320 acacgaacat cttcctcaaa tttggatctg
gctatgtaag tggctgggga agagtcttcc 1380 acaaagggag atcagcttta
gttcttcagt accttagagt tccacttgtt gaccgagcca 1440 catgtcttcg
atctacaaag ttcaccatct ataacaacat gttctgtgct ggcttccatg 1500
aaggaggtag agattcatgt caaggagata gtgggggacc ccatgttact gaagtggaag
1560 ggaccagttt cttaactgga attattagct ggggtgaaga gtgtgcaatg
aaaggcaaat 1620 atggaatata taccaaggtg tcccggtatg tcaactggat
taaggaaaaa acaaagctca 1680 ctgacaaaac tcacacatgc ccaccgtgcc
cagctccgga actcctggga ggaccgtcag 1740 tcttcctctt ccccccaaaa
cccaaggaca ccctcatgat ctcccggacc cctgaggtca 1800 catgcgtggt
ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg 1860
acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt
1920 accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc
aaggagtaca 1980 agtgcaaggt ctccaacaaa gccctcccag cccccatcga
gaaaaccatc tccaaagcca 2040 aagggcagcc ccgagaacca caggtgtaca
ccctgccccc atcccgggat gagctgacca 2100 agaaccaggt cagcctgacc
tgcctggtca aaggcttcta tcccagcgac atcgccgtgg 2160 agtgggagag
caatgggcag ccggagaaca actacaagac cacgcctccc gtgttggact 2220
ccgacggctc cttcttcctc tacagcaagc tcaccgtcga caagagcagg tggcagcagg
2280 ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac
acgcagaaga 2340 gcctctccct gtctccgggt aaaggcggtg gcggttcagg
tggaggaggg tcaggcggtg 2400 gtggatccgg cgggggcgga tccggtggcg
gagggtcagg cggtggcgga tcagcctgca 2460 ccgagcggat ggccctgcac
aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg 2520 gtggcggcgg
atcaggtggg ggtggatcag gcggtggagg ttccggtggc gggggatccg 2580
acaaaactca cacatgccca ccgtgcccag caccggaact cctgggcgga ccgtcagtct
2640 tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct
gaggtcacat 2700 gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa
gttcaactgg tacgtggacg 2760 gcgtggaggt gcataatgcc aagacaaagc
cgcgggagga gcagtacaac agcacgtacc 2820 gtgtggtcag cgtcctcacc
gtcctgcacc aggactggct gaatggcaag gagtacaagt 2880 gcaaggtctc
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag 2940
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga
3000 accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc
gccgtggagt 3060 gggagagcaa tgggcagccg gagaacaact acaagaccac
gcctcccgtg ttggactccg 3120 acggctcctt cttcctctac agcaagctca
ccgtggacaa gagcaggtgg cagcagggga 3180 acgtcttctc atgctccgtg
atgcatgagg ctctgcacaa ccactacacg cagaagagcc 3240 tctccctgtc
tccgggtaaa tga 3263 <210> SEQ ID NO 141 <211> LENGTH:
987 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FIX-089 amino acid sequence <400> SEQUENCE: 141
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5
10 15 Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe
Leu 20 25 30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
Arg Tyr Asn 35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn
Leu Glu Arg Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu
Ala Arg Glu Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe
Trp Lys Gln Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro
Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr
Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu
Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135
140 Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145 150 155 160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
Val Pro Phe 165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser
Lys Leu Thr Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr
Val Asn Ser Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Asn Ile Thr
Gln Ser Thr Gln Ser Phe Asn Asp Phe 210 215 220 Thr Arg Val Val Gly
Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 225 230 235 240 Gln Val
Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 245 250 255
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 260
265 270 Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr
Glu 275 280 285 His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
His His Asn 290 295 300 Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp
Ile Ala Leu Leu Glu 305 310 315 320 Leu Asp Glu Pro Leu Val Leu Asn
Ser Tyr Val Thr Pro Ile Cys Ile 325 330 335 Ala Asp Lys Glu Tyr Thr
Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 340 345 350 Val Ser Gly Trp
Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 355 360 365 Leu Gln
Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 370 375 380
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 385
390 395 400 Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
His Val 405 410 415 Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile
Ile Ser Trp Gly 420 425 430 Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly
Ile Tyr Thr Lys Val Ser 435 440 445 Arg Tyr Val Asn Trp Ile Lys Glu
Lys Thr Lys Leu Thr Asp Lys Thr 450 455 460 His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 465 470 475 480 Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 485 490 495 Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 500 505
510 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
515 520 525 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val 530 535 540 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr 545 550 555 560 Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr 565 570 575 Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu 580 585 590 Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 595 600 605 Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 610 615 620 Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 625 630
635 640 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser 645 650 655 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala 660 665 670 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys 675 680 685 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Cys 705 710 715 720 Thr Glu Arg Met
Ala Leu His Asn Leu Cys Gly Gly Gly Gly Ser Gly 725 730 735 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 740 745 750
Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 755
760 765 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro 770 775 780 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr 785 790 795 800 Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn 805 810 815 Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg 820 825 830 Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val 835 840 845 Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 850 855 860 Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 865 870 875
880 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
885 890 895 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe 900 905 910 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu 915 920 925 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe 930 935 940 Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly 945 950 955 960 Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr 965 970 975 Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 980 985 <210> SEQ ID NO 142
<211> LENGTH: 2588 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FIX-090
<400> SEQUENCE: 142 atgcagcgcg tgaacatgat catggcagaa
tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac tcagtgctga
atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120 gcttgccttt
tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg
240 aacatcacag attttggctc catgccctaa agagaaattg gctttcagat
tatttggatt 300 aaaaacaaag actttcttaa gagatgtaaa attttcatga
tgttttcttt tttgctaaaa 360 ctaaagaatt attcttttac atttcagttt
ttcttgatca tgaaaacgcc aacaaaattc 420 tgaatcggcc aaagaggtat
aattcaggta aattggaaga gtttgttcaa gggaatctag 480 agagagaatg
tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt tttgaaaaca 540
ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt gagtccaatc
600 catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt
tggtgtccct 660 ttggatttga aggaaagaac tgtgaattag atgtaacatg
taacattaag aatggcagat 720 gcgagcagtt ttgtaaaaat agtgctgata
acaaggtggt ttgctcctgt actgagggat 780 atcgacttgc agaaaaccag
aagtcctgtg aaccagcagt gccatttcca tgtggaagag 840 tttctgtttc
acaaacttct aagctcaccc gtgctgagac tgtttttcct gatgtggact 900
atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc acccaatcat
960 ttaatgactt cactcgggtt gttggtggag aagatgccaa accaggtcaa
ttcccttggc 1020 aggttgtttt gaatggtaaa gttgatgcat tctgtggagg
ctctatcgtt aatgaaaaat 1080 ggattgtaac tgctgcccac tgtgttgaaa
ctggtgttaa aattacagtt gtcgcaggtg 1140 aacataatat tgaggagaca
gaacatacag agcaaaagcg aaatgtgatt cgaattattc 1200 ctcaccacaa
ctacaatgca gctattaata agtacaacca tgacattgcc cttctggaac 1260
tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct gacaaggaat
1320 acacgaacat cttcctcaaa tttggatctg gctatgtaag tggctgggga
agagtcttcc 1380 acaaagggag atcagcttta gttcttcagt accttagagt
tccacttgtt gaccgagcca 1440 catgtcttcg atctacaaag ttcaccatct
ataacaacat gttctgtgct ggcttccatg 1500 aaggaggtag agattcatgt
caaggagata gtgggggacc ccatgttact gaagtggaag 1560 ggaccagttt
cttaactgga attattagct ggggtgaaga gtgtgcaatg aaaggcaaat 1620
atggaatata taccaaggtg tcccggtatg tcaactggat taaggaaaaa acaaagctca
1680 ctggtggcgg tggctccggc ggaggtgggt ccggtggcgg cggatcaggt
gggggtggat 1740 caggcggtgg aggttccggt ggcgggggat cagcgcaggt
gcagctgcag gagtctgggg 1800 gaggcttggt acagcctggg gggtccctga
gactctcctg tgcagcctct ggattcatgt 1860 ttagcaggta tgccatgagc
tgggtccgcc aggctccagg gaaggggcca gagtgggtct 1920 caggtattag
tggtagtggt ggtagtacat actacgcaga ctccgtgaag ggccggttca 1980
ccgtctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc ctgagagccg
2040 aggacacggc tgtatattac tgcgcccggg gcgccaccta caccagccgg
agcgacgtgc 2100 ccgaccagac cagcttcgac tactggggcc agggaaccct
ggtcaccgtc tcctcaggga 2160 gtgcatccgc cccaaagctt gaagaaggtg
aattttcaga agcacgcgta tctgaactga 2220 ctcaggaccc tgctgtgtct
gtggccttgg gacagacagt caggatcaca tgccaaggag 2280 acagcctcag
aaacttttat gcaagctggt accagcagaa gccaggacag gcccctactc 2340
ttgtcatcta tggtttaagt aaaaggccct cagggatccc agaccgattc tctgcctcca
2400 gctcaggaaa cacagcttcc ttgaccatca ctggggctca ggcggaagat
gaggctgact 2460 attactgcct gctgtactac ggcggcggcc agcagggcgt
gttcggcggc ggcaccaagc 2520 tgaccgtcct acgtcagccc aaggctgccc
cctcggtcac tctgttcccg ccctcttctg 2580 cggcctga 2588 <210> SEQ
ID NO 143 <211> LENGTH: 762 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FIX-90 amino acid sequence
<400> SEQUENCE: 143 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly
Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val
Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn
Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg
Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr
Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210
215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro
Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys
Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala
His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly
Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg
Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala
Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu
Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330
335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala
Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met
Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys
Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly
Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys
Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg
Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly Gly Gly 450 455
460 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
465 470 475 480 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln
Val Gln Leu 485 490 495 Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu 500 505 510 Ser Cys Ala Ala Ser Gly Phe Met Phe
Ser Arg Tyr Ala Met Ser Trp 515 520 525 Val Arg Gln Ala Pro Gly Lys
Gly Pro Glu Trp Val Ser Gly Ile Ser 530 535 540 Gly Ser Gly Gly Ser
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 545 550 555 560 Thr Val
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 565 570 575
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala 580
585 590 Thr Tyr Thr Ser Arg Ser Asp Val Pro Asp Gln Thr Ser Phe Asp
Tyr 595 600 605 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser
Ala Ser Ala 610 615 620 Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala
Arg Val Ser Glu Leu 625 630 635 640 Thr Gln Asp Pro Ala Val Ser Val
Ala Leu Gly Gln Thr Val Arg Ile 645 650 655 Thr Cys Gln Gly Asp Ser
Leu Arg Asn Phe Tyr Ala Ser Trp Tyr Gln 660 665 670 Gln Lys Pro Gly
Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser Lys 675 680 685 Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser Ser Gly Asn 690 695 700
Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 705
710 715 720 Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly Gln Gln Gly Val
Phe Gly 725 730 735 Gly Gly Thr Lys Leu Thr Val Leu Arg Gln Pro Lys
Ala Ala Pro Ser 740 745 750 Val Thr Leu Phe Pro Pro Ser Ser Ala Ala
755 760 <210> SEQ ID NO 144 <211> LENGTH: 3744
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-088 <400> SEQUENCE: 144
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaacggcgcc
gccggagcgg tggcggcgga tcaggtgggg gtggatcagg cggtggaggt 2160
tccggtggcg ggggatccgg cggtggaggt tccggtgggg gtggatcaag gaagaggagg
2220 aagagggaca tcgtgatgac ccaggccgcc cccagcgtgc ccgtgacccc
cggcgagagc 2280 gtgagcatca gctgccggag cagccggagc ctgctgcaca
gcaacggcaa cacctacctg 2340 tgctggttcc tgcagcggcc cggccagagc
ccccagctgc tgatctaccg gatgagcaac 2400 ctggccagcg gcgtgcccga
ccggttcagc ggcagcggca gcggcaccgc cttcaccctg 2460 cggatcagcc
gggtggaggc cgaggacgtg ggcgtgtact actgcatgca gcacctggag 2520
taccccttca ccttcggcag cggcaccaag ctggagatca agcggggcgg cggcggcagc
2580 ggcggcggcg gcagcggcgg cggcggcagc caggtgcagc tgcagcagag
cggcgccgag 2640 ctggtgcggc ccggcaccag cgtgaagatc agctgcaagg
ccagcggcta caccttcacc 2700 aactactggc tgggctgggt gaagcagcgg
cccggccacg gcctggagtg gatcggcgac 2760 atctaccccg gcggcggcta
caacaagtac aacgagaact tcaagggcaa ggccaccctg 2820 accgccgaca
ccagcagcag caccgcctac atgcagctga gcagcctgac cagcgaggac 2880
agcgccgtgt acttctgcgc ccgggagtac ggcaactacg actacgccat ggacagctgg
2940 ggccagggca ccagcgtgac cgtgagcagc ggtggcggtg gctccggcgg
aggtgggtcc 3000 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag
gttccggtgg cgggggatca 3060 gacaaaactc acacatgccc accgtgccca
gcaccggaac tcctgggcgg accgtcagtc 3120 ttcctcttcc ccccaaaacc
caaggacacc ctcatgatct cccggacccc tgaggtcaca 3180 tgcgtggtgg
tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 3240
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac
3300 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa
ggagtacaag 3360 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga
aaaccatctc caaagccaaa 3420 gggcagcccc gagaaccaca ggtgtacacc
ctgcccccat cccgggatga gctgaccaag 3480 aaccaggtca gcctgacctg
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 3540 tgggagagca
atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc 3600
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg
3660 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac
gcagaagagc 3720 ctctccctgt ctccgggtaa atga 3744 <210> SEQ ID
NO 145 <211> LENGTH: 1247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-088 amino acid
sequence <400> SEQUENCE: 145 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg
690 695 700 Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 725 730 735 Arg Lys Arg Arg Lys Arg Asp Ile Val
Met Thr Gln Ala Ala Pro Ser 740 745 750 Val Pro Val Thr Pro Gly Glu
Ser Val Ser Ile Ser Cys Arg Ser Ser 755 760 765 Arg Ser Leu Leu His
Ser Asn Gly Asn Thr Tyr Leu Cys Trp Phe Leu 770 775 780 Gln Arg Pro
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn 785 790 795 800
Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 805
810 815 Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly
Val 820 825 830 Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe
Gly Ser Gly 835 840 845 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
Ser Gly Gly Gly Gly 850 855 860 Ser Gly Gly Gly Gly Ser Gln Val Gln
Leu Gln Gln Ser Gly Ala Glu 865 870 875 880 Leu Val Arg Pro Gly Thr
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 885 890 895 Tyr Thr Phe Thr
Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly 900 905 910 His Gly
Leu Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Asn 915 920 925
Lys Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr 930
935 940 Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu
Asp 945 950 955 960 Ser Ala Val Tyr Phe Cys Ala Arg Glu Tyr Gly Asn
Tyr Asp Tyr Ala 965 970 975 Met Asp Ser Trp Gly Gln Gly Thr Ser Val
Thr Val Ser Ser Gly Gly 980 985 990 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 995 1000 1005 Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 1010 1015 1020 His Thr Cys
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 1025 1030 1035 Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 1040 1045
1050 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
1055 1060 1065 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu 1070 1075 1080 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser 1085 1090 1095 Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu His Gln Asp Trp 1100 1105 1110 Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala Leu 1115 1120 1125 Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 1130 1135 1140 Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 1145 1150 1155 Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 1160 1165
1170 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
1175 1180 1185 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly Ser 1190 1195 1200 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp Gln 1205 1210 1215 Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His 1220 1225 1230 Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 1235 1240 1245 <210> SEQ ID NO
146 <211> LENGTH: 5796 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVIII-041
<400> SEQUENCE: 146 atgcaaatag agctctccac ctgcttcttt
ctgtgccttt tgcgattctg ctttagtgcc 60 accagaagat actacctggg
tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120 ggtgagctgc
ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180
acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc
240 gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc
tgaggtttat 300 gatacagtgg tcattacact taagaacatg gcttcccatc
ctgtcagtct tcatgctgtt 360 ggtgtatcct actggaaagc ttctgaggga
gctgaatatg atgatcagac cagtcaaagg 420 gagaaagaag atgataaagt
cttccctggt ggaagccata catatgtctg gcaggtcctg 480 aaagagaatg
gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540
gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa
600 gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact
ttttgctgta 660 tttgatgaag ggaaaagttg gcactcagaa acaaagaact
ccttgatgca ggatagggat 720 gctgcatctg ctcgggcctg gcctaaaatg
cacacagtca atggttatgt aaacaggtct 780 ctgccaggtc tgattggatg
ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840 accactcctg
aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900
cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg
960 gaccttggac agtttctact gttttgtcat atctcttccc accaacatga
tggcatggaa 1020 gcttatgtca aagtagacag ctgtccagag gaaccccaac
tacgaatgaa aaataatgaa 1080 gaagcggaag actatgatga tgatcttact
gattctgaaa tggatgtggt caggtttgat 1140 gatgacaact ctccttcctt
tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200 tgggtacatt
acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260
cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg
1320 aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac
tcgtgaagct 1380 attcagcatg aatcaggaat cttgggacct ttactttatg
gggaagttgg agacacactg 1440 ttgattatat ttaagaatca agcaagcaga
ccatataaca tctaccctca cggaatcact 1500 gatgtccgtc ctttgtattc
aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560 ccaattctgc
caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620
actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga
1680 gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc
tgtagatcaa 1740 agaggaaacc agataatgtc agacaagagg aatgtcatcc
tgttttctgt atttgatgag 1800 aaccgaagct ggtacctcac agagaatata
caacgctttc tccccaatcc agctggagtg 1860 cagcttgagg atccagagtt
ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920 tttgatagtt
tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980
attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa
2040 atggtctatg aagacacact caccctattc ccattctcag gagaaactgt
cttcatgtcg 2100 atggaaaacc caggtctatg gattctgggg tgccacaact
cagactttcg gaacagaggc 2160 atgaccgcct tactgaaggt ttctagttgt
gacaagaaca ctggtgatta ttacgaggac 2220 agttatgaag atatttcagc
atacttgctg agtaaaaaca atgccattga accaagaagc 2280 ttctctcaaa
acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt 2340
cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa
2400 gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca
aaagaaaaca 2460 cgacactatt ttattgctgc agtggagagg ctctgggatt
atgggatgag tagctcccca 2520 catgttctaa gaaacagggc tcagagtggc
agtgtccctc agttcaagaa agttgttttc 2580 caggaattta ctgatggctc
ctttactcag cccttatacc gtggagaact aaatgaacat 2640 ttgggactcc
tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc 2700
agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat
2760 cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac
caaaacttac 2820 ttttggaaag tgcaacatca tatggcaccc actaaagatg
agtttgactg caaagcctgg 2880 gcttatttct ctgatgttga cctggaaaaa
gatgtgcact caggcctgat tggacccctt 2940 ctggtctgcc acactaacac
actgaaccct gctcatggga gacaagtgac agtacaggaa 3000 tttgctctgt
ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg 3060
gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat
3120 tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt
agtaatggct 3180 caggatcaaa ggattcgatg gtatctgctc agcatgggca
gcaatgaaaa catccattct 3240 attcatttca gtggacatgt gttcactgta
cgaaaaaaag aggagtataa aatggcactg 3300 tacaatctct atccaggtgt
ttttgagaca gtggaaatgt taccatccaa agctggaatt 3360 tggcgggtgg
aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg 3420
gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt
3480 cagattacag cttcaggaca atatggacag tgggccccaa agctggccag
acttcattat 3540 tccggatcaa tcaatgcctg gagcaccaag gagccctttt
cttggatcaa ggtggatctg 3600 ttggcaccaa tgattattca cggcatcaag
acccagggtg cccgtcagaa gttctccagc 3660 ctctacatct ctcagtttat
catcatgtat agtcttgatg ggaagaagtg gcagacttat 3720 cgaggaaatt
ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata 3780
aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat
3840 tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa
tagttgcagc 3900 atgccattgg gaatggagag taaagcaata tcagatgcac
agattactgc ttcatcctac 3960 tttaccaata tgtttgccac ctggtctcct
tcaaaagctc gacttcacct ccaagggagg 4020 agtaatgcct ggagacctca
ggtgaataat ccaaaagagt ggctgcaagt ggacttccag 4080 aagacaatga
aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg 4140
tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt
4200 cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc
tgtggtgaac 4260 tctctagacc caccgttact gactcgctac cttcgaattc
acccccagag ttgggtgcac 4320 cagattgccc tgaggatgga ggttctgggc
tgcgaggcac aggacctcta cgacaaaact 4380 cacacatgcc caccgtgccc
agctccagaa ctcctgggcg gaccgtcagt cttcctcttc 4440 cccccaaaac
ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 4500
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag
4560 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta
ccgtgtggtc 4620 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca
aggagtacaa gtgcaaggtc 4680 tccaacaaag ccctcccagc ccccatcgag
aaaaccatct ccaaagccaa agggcagccc 4740 cgagaaccac aggtgtacac
cctgccccca tcccgggatg agctgaccaa gaaccaggtc 4800 agcctgacct
gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 4860
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgttggactc cgacggctcc
4920 ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg
gaacgtcttc 4980 tcatgctccg tgatgcatga ggctctgcac aaccactaca
cgcagaagag cctctccctg 5040 tctccgggta aaggtggcgg cggatcaggt
gggggtggat caggcggtgg aggttccggt 5100 ggcgggggat cagacaaaac
tcacacatgc ccaccgtgcc cagcacctga actcctggga 5160 ggaccgtcag
tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 5220
cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac
5280 tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga
ggagcagtac 5340 aacagcacgt accgtgtggt cagcgtcctc accgtcctgc
accaggactg gctgaatggc 5400 aaggagtaca agtgcaaggt ctccaacaaa
gccctcccag cccccatcga gaaaaccatc 5460 tccaaagcca aagggcagcc
ccgagaacca caggtgtaca ccctgccccc atcccgcgat 5520 gagctgacca
agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac 5580
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc
5640 gtgttggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga
caagagcagg 5700 tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg
aggctctgca caaccactac 5760 acgcagaaga gcctctccct gtctccgggt aaatga
5796 <210> SEQ ID NO 147 <211> LENGTH: 1931 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVIII-041 amino acid sequence <400> SEQUENCE: 147 Met Gln Ile
Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys
Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25
30 Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg
35 40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser
Val Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His
Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu
Leu Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val
Ile Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His
Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu
Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys
Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155
160 Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser
165 170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly
Leu Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala
Lys Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe
Ala Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys
Asn Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg
Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg
Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr
Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280
285 Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser
290 295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu
Leu Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile
Ser Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val
Asp Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn
Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu
Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe
Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385 390 395 400
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405
410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu
Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val
Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu
Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr
Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn
Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr
Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val
Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530
535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu
Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile
Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met
Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu
Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu
Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro Glu Phe Gln
Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630 635 640 Phe
Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 645 650
655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe
660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr
Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser
Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys His Asn Ser
Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu Leu Lys Val
Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr Glu Asp Ser
Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750 Asn Asn Ala
Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 755 760 765 Lys
Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 770 775
780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu
785 790 795 800 Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro
Arg Ser Phe 805 810 815 Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala
Val Glu Arg Leu Trp 820 825 830 Asp Tyr Gly Met Ser Ser Ser Pro His
Val Leu Arg Asn Arg Ala Gln 835 840 845 Ser Gly Ser Val Pro Gln Phe
Lys Lys Val Val Phe Gln Glu Phe Thr 850 855 860 Asp Gly Ser Phe Thr
Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 865 870 875 880 Leu Gly
Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 885 890 895
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 900
905 910 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro
Arg 915 920 925 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe
Trp Lys Val 930 935 940 Gln His His Met Ala Pro Thr Lys Asp Glu Phe
Asp Cys Lys Ala Trp 945 950 955 960 Ala Tyr Phe Ser Asp Val Asp Leu
Glu Lys Asp Val His Ser Gly Leu 965 970 975 Ile Gly Pro Leu Leu Val
Cys His Thr Asn Thr Leu Asn Pro Ala His 980 985 990 Gly Arg Gln Val
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 995 1000 1005 Asp
Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 1010 1015
1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys
1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met
Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg
Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser Asn Glu Asn
Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val Phe Thr Val
Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu Tyr Asn Leu
Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110 Leu Pro Ser
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115 1120 1125 Glu
His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser 1130 1135
1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg
1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp
Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile
Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser Trp Ile Lys
Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His Gly Ile Lys
Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser Leu Tyr Ile
Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230 Gly Lys Lys
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235 1240 1245 Met
Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn 1250 1255
1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro
1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu
Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly
Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser Asp Ala Gln Ile Thr Ala
Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met Phe Ala Thr Trp Ser Pro
Ser Lys Ala Arg Leu His Leu Gln 1325 1330 1335 Gly Arg Ser Asn Ala
Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1340 1345 1350 Trp Leu Gln
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1355 1360 1365 Thr
Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys 1370 1375
1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu
1385 1390 1395 Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn
Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro
Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu Arg Ile His Pro Gln Ser
Trp Val His Gln Ile Ala 1430 1435 1440 Leu Arg Met Glu Val Leu Gly
Cys Glu Ala Gln Asp Leu Tyr Asp 1445 1450 1455 Lys Thr His Thr Cys
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1460 1465 1470 Gly Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 1475 1480 1485 Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 1490 1495
1500 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
1505 1510 1515 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr 1520 1525 1530 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu His Gln 1535 1540 1545 Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys 1550 1555 1560 Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly 1565 1570 1575 Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 1580 1585 1590 Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 1595 1600 1605 Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 1610 1615
1620 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
1625 1630 1635 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg 1640 1645 1650 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala 1655 1660 1665 Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly 1670 1675 1680 Lys Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 1685 1690 1695 Ser Gly Gly Gly Gly
Ser Asp Lys Thr His Thr Cys Pro Pro Cys 1700 1705 1710 Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 1715 1720 1725 Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 1730 1735
1740 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
1745 1750 1755 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys Thr 1760 1765 1770 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val Ser 1775 1780 1785 Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr 1790 1795 1800 Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys 1805 1810 1815 Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 1820 1825 1830 Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 1835 1840 1845 Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 1850 1855
1860 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
1865 1870 1875 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys 1880 1885 1890 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser 1895 1900 1905 Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys 1910 1915 1920 Ser Leu Ser Leu Ser Pro Gly
Lys 1925 1930 <210> SEQ ID NO 148 <211> LENGTH: 6762
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVIII-108 <400> SEQUENCE: 148
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc
60 accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca
aagtgatctc 120 ggtgagctgc ctgtggacgc aagatttcct cctagagtgc
caaaatcttt tccattcaac 180 acctcagtcg tgtacaaaaa gactctgttt
gtagaattca cggatcacct tttcaacatc 240 gctaagccaa ggccaccctg
gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300 gatacagtgg
tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360
ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg
420 gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg
gcaggtcctg 480 aaagagaatg gtccaatggc ctctgaccca ctgtgcctta
cctactcata tctttctcat 540 gtggacctgg taaaagactt gaattcaggc
ctcattggag ccctactagt atgtagagaa 600 gggagtctgg ccaaggaaaa
gacacagacc ttgcacaaat ttatactact ttttgctgta 660 tttgatgaag
ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720
gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct
780 ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat
tggaatgggc 840 accactcctg aagtgcactc aatattcctc gaaggtcaca
catttcttgt gaggaaccat 900 cgccaggcgt ccttggaaat ctcgccaata
actttcctta ctgctcaaac actcttgatg 960 gaccttggac agtttctact
gttttgtcat atctcttccc accaacatga tggcatggaa 1020 gcttatgtca
aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080
gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat
1140 gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca
tcctaaaact 1200 tgggtacatt acattgctgc tgaagaggag gactgggact
atgctccctt agtcctcgcc 1260 cccgatgaca gaagttataa aagtcaatat
ttgaacaatg gccctcagcg gattggtagg 1320 aagtacaaaa aagtccgatt
tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380 attcagcatg
aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440
ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact
1500 gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt
gaaggatttt 1560 ccaattctgc caggagaaat attcaaatat aaatggacag
tgactgtaga agatgggcca 1620 actaaatcag atcctcggtg cctgacccgc
tattactcta gtttcgttaa tatggagaga 1680 gatctagctt caggactcat
tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740 agaggaaacc
agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800
aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg
1860 cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa
tggctatgtt 1920 tttgatagtt tgcagttgtc agtttgtttg catgaggtgg
catactggta cattctaagc 1980 attggagcac agactgactt cctttctgtc
ttcttctctg gatatacctt caaacacaaa 2040 atggtctatg aagacacact
caccctattc ccattctcag gagaaactgt cttcatgtcg 2100 atggaaaacc
caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc 2160
atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac
2220 agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga
accaagaagc 2280 ttctctcaaa acccaccagt cttgaaacgc catcaacggg
aaataactcg tactactctt 2340 cagtcagatc aagaggaaat tgactatgat
gataccatat cagttgaaat gaagaaggaa 2400 gattttgaca tttatgatga
ggatgaaaat cagagccccc gcagctttca aaagaaaaca 2460 cgacactatt
ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca 2520
catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc
2580 caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact
aaatgaacat 2640 ttgggactcc tggggccata tataagagca gaagttgaag
ataatatcat ggtaactttc 2700 agaaatcagg cctctcgtcc ctattccttc
tattctagcc ttatttctta tgaggaagat 2760 cagaggcaag gagcagaacc
tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac 2820 ttttggaaag
tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg 2880
gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt
2940 ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac
agtacaggaa 3000 tttgctctgt ttttcaccat ctttgatgag accaaaagct
ggtacttcac tgaaaatatg 3060 gaaagaaact gcagggctcc ctgcaatatc
cagatggaag atcccacttt taaagagaat 3120 tatcgcttcc atgcaatcaa
tggctacata atggatacac tacctggctt agtaatggct 3180 caggatcaaa
ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct 3240
attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg
3300 tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa
agctggaatt 3360 tggcgggtgg aatgccttat tggcgagcat ctacatgctg
ggatgagcac actttttctg 3420 gtgtacagca ataagtgtca gactcccctg
ggaatggctt ctggacacat tagagatttt 3480 cagattacag cttcaggaca
atatggacag tgggccccaa agctggccag acttcattat 3540 tccggatcaa
tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg 3600
ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc
3660 ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg
gcagacttat 3720 cgaggaaatt ccactggaac cttaatggtc ttctttggca
atgtggattc atctgggata 3780 aaacacaata tttttaaccc tccaattatt
gctcgataca tccgtttgca cccaactcat 3840 tatagcattc gcagcactct
tcgcatggag ttgatgggct gtgatttaaa tagttgcagc 3900 atgccattgg
gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac 3960
tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg
4020 agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt
ggacttccag 4080 aagacaatga aagtcacagg agtaactact cagggagtaa
aatctctgct taccagcatg 4140 tatgtgaagg agttcctcat ctccagcagt
caagatggcc atcagtggac tctctttttt 4200 cagaatggca aagtaaaggt
ttttcaggga aatcaagact ccttcacacc tgtggtgaac 4260 tctctagacc
caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac 4320
cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta cgacaaaact
4380 cacacatgcc caccgtgccc agcacctgaa ctcctgggag gaccgtcagt
cttcctcttc 4440 cccccaaaac ccaaggacac cctcatgatc tcccggaccc
ctgaggtcac atgcgtggtg 4500 gtggacgtga gccacgaaga ccctgaggtc
aagttcaact ggtacgtgga cggcgtggag 4560 gtgcataatg ccaagacaaa
gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 4620 agcgtcctca
ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 4680
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc
4740 cgagaaccac aggtgtacac cctgccccca tcccgcgatg agctgaccaa
gaaccaggtc 4800 agcctgacct gcctggtcaa aggcttctat cccagcgaca
tcgccgtgga gtgggagagc 4860 aatgggcagc cggagaacaa ctacaagacc
acgcctcccg tgttggactc cgacggctcc 4920 ttcttcctct acagcaagct
caccgtcgac aagagcaggt ggcagcaggg gaacgtcttc 4980 tcatgctccg
tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 5040
tctccgggta aacggcgccg ccggagcggt ggcggcggat caggtggggg tggatcaggc
5100 ggtggaggtt ccggtggcgg gggatccggc ggtggaggtt ccggtggggg
tggatcaagg 5160 aagaggagga agagggcgca ggtgcagctg caggagtctg
ggggaggctt ggtacagcct 5220 ggggggtccc tgagactctc ctgtgcagcc
tctggattca tgtttagcag gtatgccatg 5280 agctgggtcc gccaggctcc
agggaagggg ccagagtggg tctcaggtat tagtggtagt 5340 ggtggtagta
catactacgc agactccgtg aagggccggt tcaccgtctc cagagacaat 5400
tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtatat
5460 tactgcgccc ggggcgccac ctacaccagc cggagcgacg tgcccgacca
gaccagcttc 5520 gactactggg gccagggaac cctggtcacc gtctcctcag
ggagtgcatc cgccccaaag 5580 cttgaagaag gtgaattttc agaagcacgc
gtatctgaac tgactcagga ccctgctgtg 5640 tctgtggcct tgggacagac
agtcaggatc acatgccaag gagacagcct cagaaacttt 5700 tatgcaagct
ggtaccagca gaagccagga caggccccta ctcttgtcat ctatggttta 5760
agtaaaaggc cctcagggat cccagaccga ttctctgcct ccagctcagg aaacacagct
5820 tccttgacca tcactggggc tcaggcggaa gatgaggctg actattactg
cctgctgtac 5880 tacggcggcg gccagcaggg cgtgttcggc ggcggcacca
agctgaccgt cctacgtcag 5940 cccaaggctg ccccctcggt cactctgttc
ccgccctctt ctgcggccgg tggcggtggc 6000 tccggcggag gtgggtccgg
tggcggcgga tcaggtgggg gtggatcagg cggtggaggt 6060 tccggtggcg
ggggatcaga caaaactcac acatgcccac cgtgcccagc accggaactc 6120
ctgggcggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
6180 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag 6240 ttcaactggt acgtggacgg cgtggaggtg cataatgcca
agacaaagcc gcgggaggag 6300 cagtacaaca gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg 6360 aatggcaagg agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa 6420 accatctcca
aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 6480
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc
6540 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta
caagaccacg 6600 cctcccgtgt tggactccga cggctccttc ttcctctaca
gcaagctcac cgtggacaag 6660 agcaggtggc agcaggggaa cgtcttctca
tgctccgtga tgcatgaggc tctgcacaac 6720 cactacacgc agaagagcct
ctccctgtct ccgggtaaat ga 6762 <210> SEQ ID NO 149 <211>
LENGTH: 2253 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVIII-108 amino acid sequence <400>
SEQUENCE: 149 Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu
Leu Arg Phe 1 5 10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly
Ala Val Glu Leu Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly
Glu Leu Pro Val Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys
Ser Phe Pro Phe Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu
Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro
Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala
Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105
110 His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser
115 120 125 Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys
Glu Asp 130 135 140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val
Trp Gln Val Leu 145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu
Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val
Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu
His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys
Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230
235 240 Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr 245 250 255 Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg
Lys Ser Val 260 265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro
Glu Val His Ser Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val
Arg Asn His Arg Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr
Phe Leu Thr Ala Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly
Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355
360 365 Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn
Ser 370 375 380 Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His
Pro Lys Thr 385 390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg
Ser Tyr Lys Ser Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile
Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp
Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly
Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475
480 Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro
485 490 495 His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu
Pro Lys 500 505 510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro
Gly Glu Ile Phe 515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp
Gly Pro Thr Lys Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr
Ser Ser Phe Val Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly
Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp
Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile
Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600
605 Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp
610 615 620 Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly
Tyr Val 625 630 635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His
Glu Val Ala Tyr Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr
Asp Phe Leu Ser Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His
Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser
Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725
730 735 Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser
Lys 740 745 750 Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro
Pro Val Leu 755 760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr
Leu Gln Ser Asp Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile
Ser Val Glu Met Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp
Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr
Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850
855 860 Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu
His 865 870 875 880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val
Glu Asp Asn Ile 885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg
Pro Tyr Ser Phe Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp
Gln Arg Gln Gly Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro
Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala
Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970
975 Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His
980 985 990 Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr
Ile Phe 995 1000 1005 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn
Met Glu Arg Asn 1010 1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met
Glu Asp Pro Thr Phe Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala
Ile Asn Gly Tyr Ile Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val
Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser
Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090
1095 Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met
1100 1105 1110 Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu
Ile Gly 1115 1120 1125 Glu His Leu His Ala Gly Met Ser Thr Leu Phe
Leu Val Tyr Ser 1130 1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met
Ala Ser Gly His Ile Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser
Gly Gln Tyr Gly Gln Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu
His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu
Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210
1215 Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp
1220 1225 1230 Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly
Thr Leu 1235 1240 1245 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly
Ile Lys His Asn 1250 1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg
Tyr Ile Arg Leu His Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser
Thr Leu Arg Met Glu Leu Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser
Cys Ser Met Pro Leu Gly Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser
Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 1325 1330
1335 Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu
1340 1345 1350 Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr
Gly Val 1355 1360 1365 Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser
Met Tyr Val Lys 1370 1375 1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp
Gly His Gln Trp Thr Leu 1385 1390 1395 Phe Phe Gln Asn Gly Lys Val
Lys Val Phe Gln Gly Asn Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val
Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu
Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 1430 1435 1440 Leu
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr Asp 1445 1450
1455 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
1460 1465 1470 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu 1475 1480 1485 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp Val 1490 1495 1500 Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly 1505 1510 1515 Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Tyr 1520 1525 1530 Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln 1535 1540 1545 Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 1550 1555 1560 Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 1565 1570
1575 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
1580 1585 1590 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly 1595 1600 1605 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln 1610 1615 1620 Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp 1625 1630 1635 Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg 1640 1645 1650 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 1655 1660 1665 Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 1670 1675 1680 Lys
Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1685 1690
1695 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1700 1705 1710 Ser Gly Gly Gly Gly Ser Arg Lys Arg Arg Lys Arg Ala
Gln Val 1715 1720 1725 Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln
Pro Gly Gly Ser 1730 1735 1740 Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Met Phe Ser Arg Tyr 1745 1750 1755 Ala Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Pro Glu Trp 1760 1765 1770 Val Ser Gly Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 1775 1780 1785 Ser Val Lys
Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn 1790 1795 1800 Thr
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 1805 1810
1815 Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr Thr Ser Arg Ser Asp
1820 1825 1830 Val Pro Asp Gln Thr Ser Phe Asp Tyr Trp Gly Gln Gly
Thr Leu 1835 1840 1845 Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro
Lys Leu Glu Glu 1850 1855 1860 Gly Glu Phe Ser Glu Ala Arg Val Ser
Glu Leu Thr Gln Asp Pro 1865 1870 1875 Ala Val Ser Val Ala Leu Gly
Gln Thr Val Arg Ile Thr Cys Gln 1880 1885 1890 Gly Asp Ser Leu Arg
Asn Phe Tyr Ala Ser Trp Tyr Gln Gln Lys 1895 1900 1905 Pro Gly Gln
Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser Lys Arg 1910 1915 1920 Pro
Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser Ser Gly Asn 1925 1930
1935 Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala
1940 1945 1950 Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly Gln Gln
Gly Val 1955 1960 1965 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg
Gln Pro Lys Ala 1970 1975 1980 Ala Pro Ser Val Thr Leu Phe Pro Pro
Ser Ser Ala Ala Gly Gly 1985 1990 1995 Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 2000 2005 2010 Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 2015 2020 2025 Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 2030 2035 2040 Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 2045 2050
2055 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
2060 2065 2070 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val 2075 2080 2085 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Tyr Asn 2090 2095 2100 Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp 2105 2110 2115 Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala 2120 2125 2130 Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 2135 2140 2145 Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 2150 2155 2160 Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 2165 2170
2175 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
2180 2185 2190 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly 2195 2200 2205 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp 2210 2215 2220 Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu 2225 2230 2235 His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 2240 2245 2250 <210> SEQ ID
NO 150 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 150 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10
15 Gly Gly Gly Gly Ser 20 <210> SEQ ID NO 151 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 151 Ala Leu Arg Pro Arg 1 5
<210> SEQ ID NO 152 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 152 Arg Arg Arg Arg 1 <210> SEQ ID NO 153
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 153 Leu Val
Pro Arg Gly 1 5 <210> SEQ ID NO 154 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 154 Leu Gln Gln Ser Arg Lys Val Gly
Asp Ser Pro Asn 1 5 10 <210> SEQ ID NO 155 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 155 Glu Ala Ser Tyr Pro Gly
Lys 1 5 <210> SEQ ID NO 156 <211> LENGTH: 271
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
<400> SEQUENCE: 156 Ala Gln Val Gln Leu Gln Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly 1 5 10 15 Gly Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Met Phe Ser Arg 20 25 30 Tyr Ala Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 35 40 45 Val Ser Gly Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 50 55 60 Val Lys
Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85
90 95 Cys Ala Arg Gly Ala Thr Tyr Thr Ser Arg Ser Asp Val Pro Asp
Gln 100 105 110 Thr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu Gly
Glu Phe Ser Glu Ala 130 135 140 Arg Val Ser Glu Leu Thr Gln Asp Pro
Ala Val Ser Val Ala Leu Gly 145 150 155 160 Gln Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr 165 170 175 Ala Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile 180 185 190 Tyr Gly
Leu Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala 195 200 205
Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 210
215 220 Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly
Gln 225 230 235 240 Gln Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val
Leu Arg Gln Pro 245 250 255 Lys Ala Ala Pro Ser Val Thr Leu Phe Pro
Pro Ser Ser Ala Ala 260 265 270 <210> SEQ ID NO 157
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 157 Val Val
Gly Gly Ala 1 5 <210> SEQ ID NO 158 <211> LENGTH: 5859
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 158 atgcaaatag agctctccac
ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60 accagaagat
actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120
ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac
180 acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct
tttcaacatc 240 gctaagccaa ggccaccctg gatgggtctg ctaggtccta
ccatccaggc tgaggtttat 300 gatacagtgg tcattacact taagaacatg
gcttcccatc ctgtcagtct tcatgctgtt 360 ggtgtatcct actggaaagc
ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420 gagaaagaag
atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480
aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat
540 gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt
atgtagagaa 600 gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat
ttatactact ttttgctgta 660 tttgatgaag ggaaaagttg gcactcagaa
acaaagaact ccttgatgca ggatagggat 720 gctgcatctg ctcgggcctg
gcctaaaatg cacacagtca atggttatgt aaacaggtct 780 ctgccaggtc
tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840
accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat
900 cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac
actcttgatg 960 gaccttggac agtttctact gttttgtcat atctcttccc
accaacatga tggcatggaa 1020 gcttatgtca aagtagacag ctgtccagag
gaaccccaac tacgaatgaa aaataatgaa 1080 gaagcggaag actatgatga
tgatcttact gattctgaaa tggatgtggt caggtttgat 1140 gatgacaact
ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200
tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc
1260 cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg
gattggtagg 1320 aagtacaaaa aagtccgatt tatggcatac acagatgaaa
cctttaagac tcgtgaagct 1380 attcagcatg aatcaggaat cttgggacct
ttactttatg gggaagttgg agacacactg 1440 ttgattatat ttaagaatca
agcaagcaga ccatataaca tctaccctca cggaatcact 1500 gatgtccgtc
ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560
ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca
1620 actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa
tatggagaga 1680 gatctagctt caggactcat tggccctctc ctcatctgct
acaaagaatc tgtagatcaa 1740 agaggaaacc agataatgtc agacaagagg
aatgtcatcc tgttttctgt atttgatgag 1800 aaccgaagct ggtacctcac
agagaatata caacgctttc tccccaatcc agctggagtg 1860 cagcttgagg
atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920
tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc
1980 attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt
caaacacaaa 2040 atggtctatg aagacacact caccctattc ccattctcag
gagaaactgt cttcatgtcg 2100 atggaaaacc caggtctatg gattctgggg
tgccacaact cagactttcg gaacagaggc 2160 atgaccgcct tactgaaggt
ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220 agttatgaag
atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280
ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt
2340 cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat
gaagaaggaa 2400 gattttgaca tttatgatga ggatgaaaat cagagccccc
gcagctttca aaagaaaaca 2460 cgacactatt ttattgctgc agtggagagg
ctctgggatt atgggatgag tagctcccca 2520 catgttctaa gaaacagggc
tcagagtggc agtgtccctc agttcaagaa agttgttttc 2580 caggaattta
ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat 2640
ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc
2700 agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta
tgaggaagat 2760 cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc
ctaatgaaac caaaacttac 2820 ttttggaaag tgcaacatca tatggcaccc
actaaagatg agtttgactg caaagcctgg 2880 gcttatttct ctgatgttga
cctggaaaaa gatgtgcact caggcctgat tggacccctt 2940 ctggtctgcc
acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa 3000
tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg
3060 gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt
taaagagaat 3120 tatcgcttcc atgcaatcaa tggctacata atggatacac
tacctggctt agtaatggct 3180 caggatcaaa ggattcgatg gtatctgctc
agcatgggca gcaatgaaaa catccattct 3240 attcatttca gtggacatgt
gttcactgta cgaaaaaaag aggagtataa aatggcactg 3300 tacaatctct
atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt 3360
tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg
3420 gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat
tagagatttt 3480 cagattacag cttcaggaca atatggacag tgggccccaa
agctggccag acttcattat 3540 tccggatcaa tcaatgcctg gagcaccaag
gagccctttt cttggatcaa ggtggatctg 3600 ttggcaccaa tgattattca
cggcatcaag acccagggtg cccgtcagaa gttctccagc 3660 ctctacatct
ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat 3720
cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata
3780 aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca
cccaactcat 3840 tatagcattc gcagcactct tcgcatggag ttgatgggct
gtgatttaaa tagttgcagc 3900 atgccattgg gaatggagag taaagcaata
tcagatgcac agattactgc ttcatcctac 3960 tttaccaata tgtttgccac
ctggtctcct tcaaaagctc gacttcacct ccaagggagg 4020 agtaatgcct
ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag 4080
aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg
4140 tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac
tctctttttt 4200 cagaatggca aagtaaaggt ttttcaggga aatcaagact
ccttcacacc tgtggtgaac 4260 tctctagacc caccgttact gactcgctac
cttcgaattc acccccagag ttgggtgcac 4320 cagattgccc tgaggatgga
ggttctgggc tgcgaggcac aggacctcta cgacaaaact 4380 cacacatgcc
caccgtgccc agcacctgaa ctcctgggag gaccgtcagt cttcctcttc 4440
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg
4500 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga
cggcgtggag 4560 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca
acagcacgta ccgtgtggtc 4620 agcgtcctca ccgtcctgca ccaggactgg
ctgaatggca aggagtacaa gtgcaaggtc 4680 tccaacaaag ccctcccagc
ccccatcgag aaaaccatct ccaaagccaa agggcagccc 4740 cgagaaccac
aggtgtacac cctgccccca tcccgcgatg agctgaccaa gaaccaggtc 4800
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc
4860 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgttggactc
cgacggctcc 4920 ttcttcctct acagcaagct caccgtcgac aagagcaggt
ggcagcaggg gaacgtcttc 4980 tcatgctccg tgatgcatga ggctctgcac
aaccactaca cgcagaagag cctctccctg 5040 tctccgggta aacggcgccg
ccggagcggt ggcggcggat caggtggggg tggatcaggc 5100 ggtggaggtt
ccggtggcgg gggatccggc ggtggaggtt ccggtggggg tggatcaagg 5160
aagaggagga agagggacaa aactcacaca tgcccaccgt gcccagctcc agaactcctg
5220 ggcggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat
gatctcccgg 5280 acccctgagg tcacatgcgt ggtggtggac gtgagccacg
aagaccctga ggtcaagttc 5340 aactggtacg tggacggcgt ggaggtgcat
aatgccaaga caaagccgcg ggaggagcag 5400 tacaacagca cgtaccgtgt
ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 5460 ggcaaggagt
acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 5520
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg
5580 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt
ctatcccagc 5640 gacatcgccg tggagtggga gagcaatggg cagccggaga
acaactacaa gaccacgcct 5700 cccgtgttgg actccgacgg ctccttcttc
ctctacagca agctcaccgt ggacaagagc 5760 aggtggcagc aggggaacgt
cttctcatgc tccgtgatgc atgaggctct gcacaaccac 5820 tacacgcaga
agagcctctc cctgtctccg ggtaaatga 5859 <210> SEQ ID NO 159
<211> LENGTH: 1952 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct <400> SEQUENCE: 159
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5
10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu
Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val
Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe
Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe
Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp
Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp
Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val
Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu
Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135
140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu
145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu
Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu
Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly
Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile
Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser
Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala
Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260
265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser
Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg
Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala
Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe
Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr
Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met
Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr
Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385
390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr
Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser
Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr
Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys
Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro
Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile
Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His
Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505
510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe
515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys
Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val
Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro
Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn
Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val
Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln
Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro
Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630
635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr
Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser
Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr
Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val
Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys
His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu
Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr
Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 755
760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp
Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met
Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn
Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr Arg His Tyr Phe
Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr Gly Met Ser Ser
Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845 Ser Gly Ser Val
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850 855 860 Asp Gly
Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 865 870 875
880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile
885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe
Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly
Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys
Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met Ala Pro Thr Lys
Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala Tyr Phe Ser Asp
Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970 975 Ile Gly Pro
Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 980 985 990 Gly
Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 995
1000 1005 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg
Asn 1010 1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro
Thr Phe Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly
Tyr Ile Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln
Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser
Asn Glu Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val
Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110
Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115
1120 1125 Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr
Ser 1130 1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly
His Ile Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr
Gly Gln Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser
Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser
Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His
Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230
Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235
1240 1245 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His
Asn 1250 1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg
Leu His Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg
Met Glu Leu Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser Cys Ser Met
Pro Leu Gly Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser Asp Ala Gln
Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met Phe Ala Thr
Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 1325 1330 1335 Gly Arg
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1340 1345 1350
Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1355
1360 1365 Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val
Lys 1370 1375 1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln
Trp Thr Leu 1385 1390 1395 Phe Phe Gln Asn Gly Lys Val Lys Val Phe
Gln Gly Asn Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val Val Asn Ser
Leu Asp Pro Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu Arg Ile His
Pro Gln Ser Trp Val His Gln Ile Ala 1430 1435 1440 Leu Arg Met Glu
Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr Asp 1445 1450 1455 Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1460 1465 1470
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 1475
1480 1485 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
Val 1490 1495 1500 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly 1505 1510 1515 Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr 1520 1525 1530 Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln 1535 1540 1545 Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 1550 1555 1560 Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 1565 1570 1575 Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 1580 1585 1590
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 1595
1600 1605 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 1610 1615 1620 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp 1625 1630 1635 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg 1640 1645 1650 Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala 1655 1660 1665 Leu His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly 1670 1675 1680 Lys Arg Arg Arg
Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1685 1690 1695 Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1700 1705 1710
Ser Gly Gly Gly Gly Ser Arg Lys Arg Arg Lys Arg Asp Lys Thr 1715
1720 1725 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro 1730 1735 1740 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile 1745 1750 1755 Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His 1760 1765 1770 Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu 1775 1780 1785 Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr Asn Ser 1790 1795 1800 Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp Trp 1805 1810 1815 Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 1820 1825 1830
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 1835
1840 1845 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu 1850 1855 1860 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr 1865 1870 1875 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu 1880 1885 1890 Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser 1895 1900 1905 Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln 1910 1915 1920 Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu Ala Leu His 1925 1930 1935 Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 1940 1945 1950
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 159
<210> SEQ ID NO 1 <211> LENGTH: 50 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(6)..(50) <223> OTHER INFORMATION: Any grouping of "Gly Gly
Gly Gly Ser" may be present or absent <400> SEQUENCE: 1 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10
15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
20 25 30 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly 35 40 45 Gly Ser 50 <210> SEQ ID NO 2 <211>
LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 2 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 30 <210> SEQ ID
NO 3 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 3 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10
15 Gly Gly Gly Ser 20 <210> SEQ ID NO 4 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 4 Thr Gln Ser Phe Asn Asp Phe Thr Arg
1 5 <210> SEQ ID NO 5 <211> LENGTH: 10 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic peptide
<400> SEQUENCE: 5 Ser Val Ser Gln Thr Ser Lys Leu Thr Arg 1 5
10 <210> SEQ ID NO 6 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 6 Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 1 5 10
<210> SEQ ID NO 7 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 7 Thr Thr Lys Ile Lys Pro Arg 1 5 <210> SEQ ID NO 8
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 8 Ala Leu Arg
Pro Arg Val Val Gly Gly Ala 1 5 10 <210> SEQ ID NO 9
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 9 Glu Leu Leu
Gly 1 <210> SEQ ID NO 10 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic peptide
<400> SEQUENCE: 10 Pro Lys Asn Ser Ser Met Ile Ser Asn Thr
Pro 1 5 10 <210> SEQ ID NO 11 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 11 His Gln Ser Leu Gly Thr Gln 1 5
<210> SEQ ID NO 12 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 12 His Gln Asn Leu Ser Asp Gly Lys 1 5 <210> SEQ ID
NO 13 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 13 His
Gln Asn Ile Ser Asp Gly Lys 1 5 <210> SEQ ID NO 14
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 14 Val Ile Ser
Ser His Leu Gly Gln 1 5 <210> SEQ ID NO 15 <400>
SEQUENCE: 15 000 <210> SEQ ID NO 16 <400> SEQUENCE: 16
000 <210> SEQ ID NO 17 <400> SEQUENCE: 17 000
<210> SEQ ID NO 18 <400> SEQUENCE: 18 000 <210>
SEQ ID NO 19 <400> SEQUENCE: 19 000 <210> SEQ ID NO 20
<400> SEQUENCE: 20 000
<210> SEQ ID NO 21 <400> SEQUENCE: 21 000 <210>
SEQ ID NO 22 <400> SEQUENCE: 22 000 <210> SEQ ID NO 23
<400> SEQUENCE: 23 000 <210> SEQ ID NO 24 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 24 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO
25 <211> LENGTH: 31 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (2)..(31)
<223> OTHER INFORMATION: Any grouping of "Gly Gly Gly Gly
Ser" may be present or absent <400> SEQUENCE: 25 Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 30
<210> SEQ ID NO 26 <400> SEQUENCE: 26 000 <210>
SEQ ID NO 27 <400> SEQUENCE: 27 000 <210> SEQ ID NO 28
<400> SEQUENCE: 28 000 <210> SEQ ID NO 29 <400>
SEQUENCE: 29 000 <210> SEQ ID NO 30 <400> SEQUENCE: 30
000 <210> SEQ ID NO 31 <400> SEQUENCE: 31 000
<210> SEQ ID NO 32 <400> SEQUENCE: 32 000 <210>
SEQ ID NO 33 <400> SEQUENCE: 33 000 <210> SEQ ID NO 34
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 34 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly
Gly Gly Ser Gly Gly Gly Ala Ser 20 25 <210> SEQ ID NO 35
<400> SEQUENCE: 35 000 <210> SEQ ID NO 36 <211>
LENGTH: 101 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 36 catcggatcc cccgccaccg
gaacctccac cgcctgatcc acccccacct gatccgccgc 60 caccgctccg
gcggcgccgt ttacccggag acagggagag g 101 <210> SEQ ID NO 37
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 37 Arg Arg Arg
Arg Ser 1 5 <210> SEQ ID NO 38 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 38 Arg Lys Arg Arg Lys Arg 1 5
<210> SEQ ID NO 39 <211> LENGTH: 37 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 39 agtcaagctt gtcgactccg gaactcctgg gcggacc 37
<210> SEQ ID NO 40 <211> LENGTH: 86 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 40 catcggatcc cccgccaccg gaacctccac cgcctgatcc acccccacct
gatccgccgc 60 cacctttacc cggagacagg gagagg 86 <210> SEQ ID NO
41 <211> LENGTH: 35 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer <400> SEQUENCE: 41
cagtcttgat cagacaaaac tcacacatgc ccacc 35 <210> SEQ ID NO 42
<211> LENGTH: 34 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 42 actgacgaat
tctcatttac ccggagacag ggag 34 <210> SEQ ID NO 43 <211>
LENGTH: 40 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 43 cgacaagctt gccgccacca
tggtctccca ggccctcagg 40 <210> SEQ ID NO 44 <211>
LENGTH: 156 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 44 aggagttccg gagctgggca
cggtgggcat gtgtgagttt tgtcggatcc cccgccaccg 60 gaacctccac
cgcctgatcc acccccacct gatccgccgc caccggaccc acctccgccg 120
gagccaccgc caccgggaaa tggggctcgc aggagg 156 <210> SEQ ID NO
45 <211> LENGTH: 41 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 45 Arg
Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10
15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
20 25 30 Gly Gly Ser Arg Lys Arg Arg Lys Arg 35 40 <210> SEQ
ID NO 46 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer <400> SEQUENCE: 46
gggaatgtca acaggcaggg 20 <210> SEQ ID NO 47 <211>
LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 47 cttggctttc tctccacagg c
21 <210> SEQ ID NO 48 <211> LENGTH: 62 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer
<400> SEQUENCE: 48 cgactccgga gctgggcacg gtgggcatgt
gtgagttttg tcgggaaatg gggctcgcag 60 gg 62 <210> SEQ ID NO 49
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 49 catccccagc
acgtacgtcc 20 <210> SEQ ID NO 50 <211> LENGTH: 132
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 50 gggcatgtgt gagttttgtc tgatcccccg
ccaccggaac ctccaccgcc tgatccaccc 60 ccacctgatc cgccgccacc
ggacccacct ccgccggagc caccgccacc gggaaatggg 120 gctcgcagga gg 132
<210> SEQ ID NO 51 <211> LENGTH: 23 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 51 gacaaaactc acacatgccc acc 23 <210> SEQ ID NO 52
<211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 52 gcagaattct
catttacccg gag 23 <210> SEQ ID NO 53 <211> LENGTH: 152
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 53 gagttccgga gctgggcacg gtgggcatgt
gtgagttttg tctgatcccc cgccaccgga 60 acctccaccg cctgatccac
ccccacctga tccgccgcca ccggacccac ctccgccgga 120 gccaccgcca
cctcggcctt ggggtttgct gg 152 <210> SEQ ID NO 54 <211>
LENGTH: 82 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 54 cagtctggat ccggcggtgg
aggttccggt gggggtggat caaggaagag gaggaagagg 60 attgtggggg
gcaaggtgtg cc 82 <210> SEQ ID NO 55 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 55 atgtctgaat tctcatttac ccggagacag
ggagagg 37 <210> SEQ ID NO 56 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 56 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 1 5 10 <210> SEQ ID NO 57 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 57 Gly Gly Gly Gly Ser 1 5
<210> SEQ ID NO 58 <211> LENGTH: 102 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 58 actgacaagc ttgccgccac catggagaca gacacactcc tgctatgggt
actgctgctc 60 tgggttccag gttccactgg tattgtgggg ggcaaggtgt gc 102
<210> SEQ ID NO 59 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 59 actgacgcgg ccgcgccgcc accatggtct cccagg 36 <210>
SEQ ID NO 60 <211> LENGTH: 35 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 60 actgacctcg agttatcggc cttggggttt gctgg 35 <210>
SEQ ID NO 61 <211> LENGTH: 118 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 61 ractgacgga tcccccgcca ccggaacctc caccgcctga tccaccccca
cctgatccgc 60 cgccaccgga cccacctccg ccggagccac cgccacctcg
gccttggggt ttgctggc 118 <210> SEQ ID NO 62 <211>
LENGTH: 35 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 62 actgacgcgg ccgcgccgcc
accatggaga cagac 35 <210> SEQ ID NO 63 <211> LENGTH: 36
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer
<400> SEQUENCE: 63 actgacctcg agttagggaa atggggctcg caggag 36
<210> SEQ ID NO 64 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 64 agctctcgag tcatttaccc ggagacaggg 30 <210> SEQ ID
NO 65 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 65 Gly
Gly Gly Gly Ser Ala Leu Arg Pro Arg 1 5 10 <210> SEQ ID NO 66
<211> LENGTH: 1272 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-027 amino acid
sequence <400> SEQUENCE: 66 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg
690 695 700 Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 725 730 735 Arg Lys Arg Arg Lys Arg Ala Glu Val
Gln Leu Val Gln Ser Gly Ala 740 745 750 Glu Val Asn Lys Pro Gly Ala
Ser Val Lys Val Ser Cys Lys Ala Ser 755 760 765 Gly Tyr Thr Phe Thr
Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro 770 775 780 Gly Gln Gly
Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 785 790 795 800
Thr Asn Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp 805
810 815 Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
Asp 820 825 830 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala Leu
Tyr Asn Arg 835 840 845 Asn Asp Arg Ser Pro Asn Trp Phe Asp Pro Trp
Gly Gln Gly Thr Leu 850 855 860 Val Thr Val Ser Ser Gly Ser Ala Ser
Ala Pro Thr Leu Lys Leu Glu 865 870 875 880 Glu Gly Glu Phe Ser Glu
Ala Arg Val Gln Ala Val Leu Thr Gln Pro 885 890 895 Pro Ser Val Ser
Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 900 905 910 Gly Asn
Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro 915 920 925
Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 930
935 940 Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala
Thr 945 950 955 960 Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala
Asp Tyr Tyr Cys 965 970 975 Gln Val Trp Asp Ser Ser Ser Asp His Val
Val Phe Gly Gly Gly Thr 980 985 990 Lys Leu Thr Val Leu Gly Gln Pro
Lys Ala Ala Pro Ser Val Thr Leu 995 1000 1005 Phe Pro Pro Ser Ala
Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 1010 1015 1020 Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1025 1030 1035 Gly
Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 1040 1045
1050 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
1055 1060 1065 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 1070 1075 1080 Val Thr Cys Val Val Val Asp Val Ser His Glu
Asp Pro Glu Val 1085 1090 1095 Lys Phe Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys 1100 1105 1110 Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val
1115 1120 1125 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu 1130 1135 1140 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile Glu 1145 1150 1155 Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 1160 1165 1170 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val 1175 1180 1185 Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 1190 1195 1200 Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 1205 1210 1215 Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 1220 1225
1230 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
1235 1240 1245 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln 1250 1255 1260 Lys Ser Leu Ser Leu Ser Pro Gly Lys 1265
1270 <210> SEQ ID NO 67 <211> LENGTH: 3819 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence of FVII-027 <400> SEQUENCE: 67 atggtctccc aggccctcag
gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg
taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120
gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc
180 tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct
gttctggatt 240 tcttacagtg atggggacca gtgtgcctca agtccatgcc
agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc
ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct
gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca
cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca 480
gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa
540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg
ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc
agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc
cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg
cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg
cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac 840
atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc
900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc
attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg
agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag
cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg
tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag
gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200
agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag
1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt
cctcctgcga 1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt
ccggtggcgg cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt
ggcgggggat ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga
actcctgggc ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca
ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat
1620 gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt
cagcgtcctc 1680 accgtcctgc accaggactg gctgaatggc aaggagtaca
agtgcaaggt ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc
tccaaagcca aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc
atcccgggat gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca
aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920
ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc
1980 tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt
ctcatgctcc 2040 gtgatgcatg aggctctgca caaccactac acgcagaaga
gcctctccct gtctccgggt 2100 aaacggcgcc gccggagcgg tggcggcgga
tcaggtgggg gtggatcagg cggtggaggt 2160 tccggtggcg ggggatccgg
cggtggaggt tccggtgggg gtggatcaag gaagaggagg 2220 aagagggcgg
aagtgcagct ggtgcagtct ggagctgagg tgaataagcc tggggcctca 2280
gtgaaggtct cctgcaaggc ttctggatac accttcaccg gctactatat gcactgggtg
2340 cgacaggccc ctggacaagg gcttgagtgg atgggatgga tcaaccctaa
cagtggtggc 2400 acaaactatg cacagaagtt tcagggctgg gtcaccatga
ccagggacac gtccatcagc 2460 accgcctaca tggagctgag caggctgaga
tctgacgaca cggccgtgta ttactgtgcg 2520 agaggccgtg ctttgtataa
ccggaacgac cggtccccca actggttcga cccctggggc 2580 cagggaaccc
tggtcaccgt ctcctcaggg agtgcatccg ccccaaccct taagcttgaa 2640
gaaggtgaat tctcagaagc acgcgtacag gctgtgctga ctcagccgcc ctcggtgtca
2700 gtggccccag gacagacggc caggattacc tgtgggggaa acaacattgg
aagtaaaagt 2760 gtgcagtggt accagcagaa gccaggccag gcccctgtgc
tggtcgtcta tgatgatagc 2820 gaccggccct cagggatccc tgagcgattc
tctggctcca actctgggaa catggccacc 2880 ctgaccatca gcagggtcga
agccggggat gaggccgact attactgtca ggtgtgggat 2940 agtagtagtg
atcatgtggt attcggcgga gggaccaagc tgaccgtcct aggtcagccc 3000
aaggctgccc cctcggtcac tctgttcccg ccgtccgcgg ccgctggtgg cggtggctcc
3060 ggcggaggtg ggtccggtgg cggcggatca ggtgggggtg gatcaggcgg
tggaggttcc 3120 ggtggcgggg gatcagacaa aactcacaca tgcccaccgt
gcccagcacc tgaactcctg 3180 ggaggaccgt cagtcttcct cttcccccca
aaacccaagg acaccctcat gatctcccgg 3240 acccctgagg tcacatgcgt
ggtggtggac gtgagccacg aagaccctga ggtcaagttc 3300 aactggtacg
tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 3360
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat
3420 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat
cgagaaaacc 3480 atctccaaag ccaaagggca gccccgagaa ccacaggtgt
acaccctgcc cccatcccgc 3540 gatgagctga ccaagaacca ggtcagcctg
acctgcctgg tcaaaggctt ctatcccagc 3600 gacatcgccg tggagtggga
gagcaatggg cagccggaga acaactacaa gaccacgcct 3660 cccgtgttgg
actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 3720
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac
3780 tacacgcaga agagcctctc cctgtctccg ggtaaatga 3819 <210>
SEQ ID NO 68 <211> LENGTH: 577 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct:
Genscript-FVII-027-1 DNA sequence <400> SEQUENCE: 68
gaagagcctc tccctgtctc cgggtaaacg gcgccgccgg agcggtggcg gcggatcagg
60 tgggggtgga tcaggcggtg gaggttccgg tggcggggga tccggcggtg
gaggttccgg 120 tgggggtgga tcaaggaaga ggaggaagag ggcggaagtg
cagctggtgc agtctggagc 180 tgaggtgaat aagcctgggg cctcagtgaa
ggtctcctgc aaggcttctg gatacacctt 240 caccggctac tatatgcact
gggtgcgaca ggcccctgga caagggcttg agtggatggg 300 atggatcaac
cctaacagtg gtggcacaaa ctatgcacag aagtttcagg gctgggtcac 360
catgaccagg gacacgtcca tcagcaccgc ctacatggag ctgagcaggc tgagatctga
420 cgacacggcc gtgtattact gtgcgagagg ccgtgctttg tataaccgga
acgaccggtc 480 ccccaactgg ttcgacccct ggggccaggg aaccctggtc
accgtctcct cagggagtgc 540 atccgcccca acccttaagc ttgaagaagg tgaattc
577 <210> SEQ ID NO 69 <211> LENGTH: 1179 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
Genscript-FVII-026-2 DNA sequence <400> SEQUENCE: 69
gaattctcag aagcacgcgt acaggctgtg ctgactcagc cgccctcggt gtcagtggcc
60 ccaggacaga cggccaggat tacctgtggg ggaaacaaca ttggaagtaa
aagtgtgcag 120 tggtaccagc agaagccagg ccaggcccct gtgctggtcg
tctatgatga tagcgaccgg 180 ccctcaggga tccctgagcg attctctggc
tccaactctg ggaacatggc caccctgacc 240 atcagcaggg tcgaagccgg
ggatgaggcc gactattact gtcaggtgtg ggatagtagt 300 agtgatcatg
tggtattcgg cggagggacc aagctgaccg tcctaggtca gcccaaggct 360
gccccctcgg tcactctgtt cccgccgtcc gcggccgctg gtggcggtgg ctccggcgga
420 ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg
ttccggtggc 480 gggggatcag acaaaactca cacatgccca ccgtgcccag
cacctgaact cctgggagga 540 ccgtcagtct tcctcttccc cccaaaaccc
aaggacaccc tcatgatctc ccggacccct 600 gaggtcacat gcgtggtggt
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 660 tacgtggacg
gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 720
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag
780 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa
aaccatctcc 840 aaagccaaag ggcagccccg agaaccacag gtgtacaccc
tgcccccatc ccgcgatgag 900 ctgaccaaga accaggtcag cctgacctgc
ctggtcaaag gcttctatcc cagcgacatc 960 gccgtggagt gggagagcaa
tgggcagccg gagaacaact acaagaccac gcctcccgtg 1020 ttggactccg
acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 1080
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg
1140 cagaagagcc tctccctgtc tccgggtaaa tgagaattc 1179 <210>
SEQ ID NO 70 <211> LENGTH: 1250 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-037 amino
acid sequence. <400> SEQUENCE: 70 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu His Lys
Asp Asp Gln Leu Ile Cys 115 120 125 Val Asn Glu Asn Gly Gly Cys Glu
Gln Tyr Cys Ser Asp His Thr Gly 130 135 140 Thr Lys Arg Ser Cys Arg
Cys His Glu Gly Tyr Ser Leu Leu Ala Asp 145 150 155 160 Gly Val Ser
Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro 165 170 175 Ile
Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly 180 185
190 Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu
195 200 205 Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr
Ile Trp 210 215 220 Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys
Asn Trp Arg Asn 225 230 235 240 Leu Ile Ala Val Leu Gly Glu His Asp
Leu Ser Glu His Asp Gly Asp 245 250 255 Glu Gln Ser Arg Arg Val Ala
Gln Val Ile Ile Pro Ser Thr Tyr Val 260 265 270 Pro Gly Thr Thr Asn
His Asp Ile Ala Leu Leu Arg Leu His Gln Pro 275 280 285 Val Val Leu
Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg Thr 290 295 300 Phe
Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly 305 310
315 320 Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met
Val 325 330 335 Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln
Gln Ser Arg 340 345 350 Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr
Met Phe Cys Ala Gly 355 360 365 Tyr Ser Asp Gly Ser Lys Asp Ser Cys
Lys Gly Asp Ser Gly Gly Pro 370 375 380 His Ala Thr His Tyr Arg Gly
Thr Trp Tyr Leu Thr Gly Ile Val Ser 385 390 395 400 Trp Gly Gln Gly
Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg 405 410 415 Val Ser
Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro 420 425 430
Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser 435
440 445 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly 450 455 460 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His
Thr Cys Pro 465 470 475 480 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe 485 490 495 Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val 500 505 510 Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe 515 520 525 Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 530 535 540 Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 545 550 555
560 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
565 570 575 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys Ala 580 585 590 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg 595 600 605 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly 610 615 620 Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro 625 630 635 640 Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 645 650 655 Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 660 665 670 Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 675 680
685 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly
690 695 700 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 705 710 715 720 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly 725 730 735 Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 740 745 750 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 755 760 765 Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 770 775 780 His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 785 790 795 800
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 805
810 815 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 820 825 830 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 835 840 845 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser 850 855 860 Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu 865 870 875 880 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 885 890 895 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 900 905 910 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 915 920 925
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 930
935 940 Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 945 950 955 960 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly 965 970 975 Ser Ala Glu Val Gln Leu Val Gln Ser Gly
Ala Glu Val Asn Lys Pro 980 985 990 Gly Ala Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr 995 1000 1005 Gly Tyr Tyr Met His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 1010 1015 1020 Glu Trp Met
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr 1025 1030 1035 Ala
Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser 1040 1045
1050 Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp
1055 1060 1065 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala Leu Tyr
Asn Arg 1070 1075 1080 Asn Asp Arg Ser Pro Asn Trp Phe Asp Pro Trp
Gly Gln Gly Thr 1085 1090 1095 Leu Val Thr Val Ser Ser Gly Ser Ala
Ser Ala Pro Thr Leu Lys 1100 1105 1110 Leu Glu Glu Gly Glu Phe Ser
Glu Ala Arg Val Gln Ala Val Leu 1115 1120 1125 Thr Gln Pro Pro Ser
Val Ser Val Ala Pro Gly Gln Thr Ala Arg 1130 1135 1140 Ile Thr Cys
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val Gln Trp 1145 1150 1155 Tyr
Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 1160 1165
1170 Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
1175 1180 1185 Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser Arg Val
Glu Ala 1190 1195 1200 Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp
Asp Ser Ser Ser 1205 1210 1215 Asp His Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 1220 1225 1230 Gln Pro Lys Ala Ala Pro Ser
Val Thr Leu Phe Pro Pro Ser Ala 1235 1240 1245
Ala Ala 1250 <210> SEQ ID NO 71 <211> LENGTH: 3756
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FIX-037 DNA sequence <400> SEQUENCE: 71 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg
gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg
aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt
ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg
cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780
cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac
840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt
gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg
tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc
acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga
ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt
acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140
gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc
1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag
ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac
gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg tggctccggc
ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat caggcggtgg
aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440 ccaccgtgcc
cagctccgga actcctgggc ggaccgtcag tcttcctctt ccccccaaaa 1500
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg
1560 agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga
ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac aacagcacgt
accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg gctgaatggc
aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag cccccatcga
gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800 caggtgtaca
ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 1860
tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag
1920 ccggagaaca actacaagac cacgcctccc gtgttggact ccgacggctc
cttcttcctc 1980 tacagcaagc tcaccgtgga caagagcagg tggcagcagg
ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca caaccactac
acgcagaaga gcctctccct gtctccgggt 2100 aaaggtggcg gcggatcagg
tgggggtgga tcaggcggtg gaggttccgg tggcggggga 2160 tcagacaaaa
ctcacacatg cccaccgtgc ccagcacctg aactcctggg aggaccgtca 2220
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc
2280 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa
ctggtacgtg 2340 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg
aggagcagta caacagcacg 2400 taccgtgtgg tcagcgtcct caccgtcctg
caccaggact ggctgaatgg caaggagtac 2460 aagtgcaagg tctccaacaa
agccctccca gcccccatcg agaaaaccat ctccaaagcc 2520 aaagggcagc
cccgagaacc acaggtgtac accctgcccc catcccgcga tgagctgacc 2580
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg
2640 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc
cgtgttggac 2700 tccgacggct ccttcttcct ctacagcaag ctcaccgtcg
acaagagcag gtggcagcag 2760 gggaacgtct tctcatgctc cgtgatgcat
gaggctctgc acaaccacta cacgcagaag 2820 agcctctccc tgtctccggg
taaaggtggc ggtggctccg gcggaggtgg gtccggtggc 2880 ggcggatcag
gtgggggtgg atcaggcggt ggaggttccg gtggcggggg atcagcggaa 2940
gtgcagctgg tgcagtctgg agctgaggtg aataagcctg gggcctcagt gaaggtctcc
3000 tgcaaggctt ctggatacac cttcaccggc tactatatgc actgggtgcg
acaggcccct 3060 ggacaagggc ttgagtggat gggatggatc aaccctaaca
gtggtggcac aaactatgca 3120 cagaagtttc agggctgggt caccatgacc
agggacacgt ccatcagcac cgcctacatg 3180 gagctgagca ggctgagatc
tgacgacacg gccgtgtatt actgtgcgag aggccgtgct 3240 ttgtataacc
ggaacgaccg gtcccccaac tggttcgacc cctggggcca gggaaccctg 3300
gtcaccgtct cctcagggag tgcatccgcc ccaaccctta agcttgaaga aggtgaattt
3360 tcagaagcac gcgtacaggc tgtgctgact cagccgccct cggtgtcagt
ggccccagga 3420 cagacggcca ggattacctg tgggggaaac aacattggaa
gtaaaagtgt gcagtggtac 3480 cagcagaagc caggccaggc ccctgtgctg
gtcgtctatg atgatagcga ccggccctca 3540 gggatccctg agcgattctc
tggctccaac tctgggaaca tggccaccct gaccatcagc 3600 agggtcgaag
ccggggatga ggccgactat tactgtcagg tgtgggatag tagtagtgat 3660
catgtggtat tcggcggagg gaccaagctg accgtcctag gtcagcccaa ggctgccccc
3720 tcggtcactc tgttcccgcc gtccgcggcc gcttga 3756 <210> SEQ
ID NO 72 <211> LENGTH: 1174 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-053 amino acid
sequence <400> SEQUENCE: 72 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Glu
Val Gln Leu Val Gln Ser Gly Ala Glu Val 20 25 30 Asn Lys Pro Gly
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 35 40 45 Thr Phe
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 50 55 60
Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 65
70 75 80 Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp
Thr Ser 85 90 95 Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
Ser Asp Asp Thr 100 105 110 Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala
Leu Tyr Asn Arg Asn Asp 115 120 125 Arg Ser Pro Asn Trp Phe Asp Pro
Trp Gly Gln Gly Thr Leu Val Thr 130 135 140 Val Ser Ser Gly Ser Ala
Ser Ala Pro Thr Leu Lys Leu Glu Glu Gly 145 150 155 160 Glu Phe Ser
Glu Ala Arg Val Gln Ala Val Leu Thr Gln Pro Pro Ser 165 170 175 Val
Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 180 185
190 Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln
195 200 205 Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser
Gly Ile 210 215 220 Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met
Ala Thr Leu Thr 225 230 235 240 Ile Ser Arg Val Glu Ala Gly Asp Glu
Ala Asp Tyr Tyr Cys Gln Val 245 250 255 Trp Asp Ser Ser Ser Asp His
Val Val Phe Gly Gly Gly Thr Lys Leu 260 265 270 Thr Val Leu Gly Gln
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 275 280 285 Pro Ser Ala
Ala Ala Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp 290 295 300 Gly
Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys 305 310
315 320 Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu
Gly 325 330 335 Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys
Val Asn Glu 340 345 350 Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His
Thr Gly Thr Lys Arg 355 360 365 Ser Cys Arg Cys His Glu Gly Tyr Ser
Leu Leu Ala Asp Gly Val Ser 370 375 380 Cys Thr Pro Thr Val Glu Tyr
Pro Cys Gly Lys Ile Pro Ile Leu Glu 385 390 395 400 Lys Arg Asn Ala
Ser Lys Pro Gln Gly Arg Arg Lys Arg Arg Lys Arg 405 410 415 Ile Val
Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 420 425 430
Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 435
440 445 Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys
Asn 450 455 460 Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu
Ser Glu His 465 470 475 480 Asp Gly Asp Glu Gln Ser Arg Arg Val Ala
Gln Val Ile Ile Pro Ser 485 490 495 Thr Tyr Val Pro Gly Thr Thr Asn
His Asp Ile Ala Leu Leu Arg Leu 500 505 510 His Gln Pro Val Val Leu
Thr Asp His Val Val Pro Leu Cys Leu Pro 515 520 525 Glu Arg Thr Phe
Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu
530 535 540 Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala
Leu Glu 545 550 555 560 Leu Met Val Leu Asn Val Pro Arg Leu Met Thr
Gln Asp Cys Leu Gln 565 570 575 Gln Ser Arg Lys Val Gly Asp Ser Pro
Asn Ile Thr Glu Tyr Met Phe 580 585 590 Cys Ala Gly Tyr Ser Asp Gly
Ser Lys Asp Ser Cys Lys Gly Asp Ser 595 600 605 Gly Gly Pro His Ala
Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly 610 615 620 Ile Val Ser
Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val 625 630 635 640
Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 645
650 655 Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly
Gly 660 665 670 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 675 680 685 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr His 690 695 700 Thr Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val 705 710 715 720 Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 725 730 735 Pro Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 740 745 750 Val Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 755 760 765
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 770
775 780 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys 785 790 795 800 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile 805 810 815 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro 820 825 830 Pro Ser Arg Asp Glu Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu 835 840 845 Val Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 850 855 860 Gly Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 865 870 875 880 Asp
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 885 890
895 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
900 905 910 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys Gly 915 920 925 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 930 935 940 Gly Gly Ser Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu 945 950 955 960 Leu Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp 965 970 975 Thr Leu Met Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 980 985 990 Val Ser His
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 995 1000 1005
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 1010
1015 1020 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 1025 1030 1035 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys 1040 1045 1050 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly 1055 1060 1065 Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Asp 1070 1075 1080 Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 1085 1090 1095 Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 1100 1105 1110 Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 1115 1120 1125
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 1130
1135 1140 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala 1145 1150 1155 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly 1160 1165 1170 Lys <210> SEQ ID NO 73 <211>
LENGTH: 3525 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-053 DNA sequence <400> SEQUENCE: 73
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcggaagtgc agctggtgca gtctggagct gaggtgaata agcctggggc
ctcagtgaag 120 gtctcctgca aggcttctgg atacaccttc accggctact
atatgcactg ggtgcgacag 180 gcccctggac aagggcttga gtggatggga
tggatcaacc ctaacagtgg tggcacaaac 240 tatgcacaga agtttcaggg
ctgggtcacc atgaccaggg acacgtccat cagcaccgcc 300 tacatggagc
tgagcaggct gagatctgac gacacggccg tgtattactg tgcgagaggc 360
cgtgctttgt ataaccggaa cgaccggtcc cccaactggt tcgacccctg gggccaggga
420 accctggtca ccgtctcctc agggagtgca tccgccccaa cccttaaact
tgaagaaggt 480 gaattttcag aagcacgcgt acaggctgtg ctgactcagc
cgccctcggt gtcagtggcc 540 ccaggacaga cggccaggat tacctgtggg
ggaaacaaca ttggaagtaa aagtgtgcag 600 tggtaccagc agaagccagg
ccaggcccct gtgctggtcg tctatgatga tagcgaccgg 660 ccctcaggga
tccctgagcg attctctggc tccaactctg ggaacatggc caccctgacc 720
atcagcaggg tcgaagccgg ggatgaggcc gactattact gtcaggtgtg ggatagtagt
780 agtgatcatg tggtattcgg cggagggacc aagctgaccg tcctaggtca
gcccaaggct 840 gccccctcgg tcactctgtt cccgccgtcc gcggccgcta
ggacgaagct gttctggatt 900 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 960 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 1020 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 1080
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
1140 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 1200 aaaagaaatg ccagcaaacc ccaaggccga aggaagagga
ggaagaggat tgtggggggc 1260 aaggtgtgcc ccaaagggga gtgtccatgg
caggtcctgt tgttggtgaa tggagctcag 1320 ttgtgtgggg ggaccctgat
caacaccatc tgggtggtct ccgcggccca ctgtttcgac 1380 aaaatcaaga
actggaggaa cctgatcgcg gtgctgggcg agcacgacct cagcgagcac 1440
gacggggatg agcagagccg gcgggtggcg caggtcatca tccccagcac gtacgtcccg
1500 ggcaccacca accacgacat cgcgctgctc cgcctgcacc agcccgtggt
cctcactgac 1560 catgtggtgc ccctctgcct gcccgaacgg acgttctctg
agaggacgct ggccttcgtg 1620 cgcttctcat tggtcagcgg ctggggccag
ctgctggacc gtggcgccac ggccctggag 1680 ctcatggtcc tcaacgtgcc
ccggctgatg acccaggact gcctgcagca gtcacggaag 1740 gtgggagact
ccccaaatat cacggagtac atgttctgtg ccggctactc ggatggcagc 1800
aaggactcct gcaaggggga cagtggaggc ccacatgcca cccactaccg gggcacgtgg
1860 tacctgacgg gcatcgtcag ctggggccag ggctgcgcaa ccgtgggcca
ctttggggtg 1920 tacaccaggg tctcccagta catcgagtgg ctgcaaaagc
tcatgcgctc agagccacgc 1980 ccaggagtcc tcctgcgagc cccatttccc
ggtggcggtg gctccggcgg aggtgggtcc 2040 ggtggcggcg gatcaggtgg
gggtggatca ggcggtggag gttccggtgg cgggggatcc 2100 gacaaaactc
acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc 2160
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
2220 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 2280 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 2340 cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 2400 tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 2460 gggcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 2520
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
2580 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gttggactcc 2640 gacggctcct tcttcctcta cagcaagctc accgtggaca
agagcaggtg gcagcagggg 2700 aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 2760 ctctccctgt ctccgggtaa
aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 2820 ggttccggtg
gcgggggatc cgacaaaact cacacatgcc caccgtgccc agcacctgaa 2880
ctcctgggag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc
2940 tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga
ccctgaggtc 3000 aagttcaact ggtacgtgga cggcgtggag gtgcataatg
ccaagacaaa gccgcgggag 3060 gagcagtaca acagcacgta ccgtgtggtc
agcgtcctca ccgtcctgca ccaggactgg 3120 ctgaatggca aggagtacaa
gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 3180 aaaaccatct
ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 3240
tcccgcgatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat
3300 cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa
ctacaagacc 3360 acgcctcccg tgttggactc cgacggctcc ttcttcctct
acagcaagct caccgtggac 3420 aagagcaggt ggcagcaggg gaacgtcttc
tcatgctccg tgatgcatga ggctctgcac 3480 aaccactaca cgcagaagag
cctctccctg tctccgggta aatga 3525
<210> SEQ ID NO 74 <211> LENGTH: 982 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-044 amino
acid sequence <400> SEQUENCE: 74 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805
810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930
935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu
Arg Trp Ala Leu 965 970 975 His Asn Leu Cys Gly Gly 980 <210>
SEQ ID NO 75 <211> LENGTH: 2949 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-044 DNA
sequence <400> SEQUENCE: 75 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320
gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg cggatcaggt
1380 gggggtggat caggcggtgg aggttccggt ggcgggggat ccgacaaaac
tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc ggaccgtcag
tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat ctcccggacc
cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag accctgaggt
caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620 gccaagacaa
agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1680
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa
1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc
ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat gagctgacca
agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta tcccagcgac
atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca actacaagac
cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980 tacagcaagc
tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2040
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt
2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg gaggttccgg
tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg
aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa acccaaggac
accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg tggtggacgt
gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340 gacggcgtgg
aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 2400
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac
2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat
ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac accctgcccc
catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac ctgcctggtc
aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga gcaatgggca
gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700 tccgacggct
ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag 2760
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag
2820 agcctctccc tgtctccggg taaaggtggc ggcggatcag gtgggggtgg
atcaggcggt 2880 ggaggttccg gtggcggggg atcagcctgc accgagcggt
gggccctgca caacctgtgc 2940 ggcgggtga 2949 <210> SEQ ID NO 76
<211> LENGTH: 982 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct: FVII-045 amino acid sequence
<400> SEQUENCE: 76 Met Val Ser Gln Ala Leu Arg Leu Leu Cys
Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val
Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg
Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu
Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg
Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80
Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85
90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu
Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp
Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr
Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His
Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr
Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu
Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185 190 Gly Gly
Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 195 200 205
Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 210
215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp
Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser
Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val Ala Gln Val
Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr Asn His Asp
Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val Leu Thr Asp
His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr Phe Ser Glu
Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310 315 320 Gly
Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 325 330
335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser
340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe
Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly
Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg Gly Thr Trp
Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln Gly Cys Ala
Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val Ser Gln Tyr
Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430 Pro Arg Pro
Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435 440 445 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455
460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys
465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555 560 Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 565 570 575
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 580
585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 690 695 700
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 705
710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val Val Asp Val Ser 755 760 765 His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790 795 800 Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 805 810 815 Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 820 825
830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910 Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915 920 925 Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 930 935 940 Ser
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 945 950
955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu Arg Met Ala
Leu 965 970 975
His Asn Leu Cys Gly Gly 980 <210> SEQ ID NO 77 <211>
LENGTH: 2949 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-045 DNA sequence <400> SEQUENCE: 77
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctgggc ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtgga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaaggtggcg
gcggatcagg tgggggtgga tcaggcggtg gaggttccgg tggcggggga 2160
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg aggaccgtca
2220 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac
ccctgaggtc 2280 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg
tcaagttcaa ctggtacgtg 2340 gacggcgtgg aggtgcataa tgccaagaca
aagccgcggg aggagcagta caacagcacg 2400 taccgtgtgg tcagcgtcct
caccgtcctg caccaggact ggctgaatgg caaggagtac 2460 aagtgcaagg
tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 2520
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccgcga tgagctgacc
2580 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga
catcgccgtg 2640 gagtgggaga gcaatgggca gccggagaac aactacaaga
ccacgcctcc cgtgttggac 2700 tccgacggct ccttcttcct ctacagcaag
ctcaccgtcg acaagagcag gtggcagcag 2760 gggaacgtct tctcatgctc
cgtgatgcat gaggctctgc acaaccacta cacgcagaag 2820 agcctctccc
tgtctccggg taaaggtggc ggcggatcag gtgggggtgg atcaggcggt 2880
ggaggttccg gtggcggggg atcagcctgc accgagcgga tggccctgca caacctgtgc
2940 ggcgggtga 2949 <210> SEQ ID NO 78 <211> LENGTH:
982 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-046 amino acid sequence <400> SEQUENCE: 78
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Ile Val 180 185 190 Gly Gly Lys Val Cys Pro Lys Gly Glu
Cys Pro Trp Gln Val Leu Leu 195 200 205 Leu Val Asn Gly Ala Gln Leu
Cys Gly Gly Thr Leu Ile Asn Thr Ile 210 215 220 Trp Val Val Ser Ala
Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 225 230 235 240 Asn Leu
Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 245 250 255
Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 260
265 270 Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His
Gln 275 280 285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu
Pro Glu Arg 290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg
Phe Ser Leu Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg
Gly Ala Thr Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg
Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly
Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr
Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380
Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385
390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val
Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu
Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro
Phe Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys 465 470 475 480 Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 485 490 495 Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 500 505
510 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
515 520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 545 550 555 560 Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys 565 570 575 Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600 605 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 610 615 620 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 625 630
635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly 645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala Leu His Asn
675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly
Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro Pro
Cys Pro Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780 Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785 790
795 800 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn 805 810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905 910
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 915
920 925 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu 930 935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys
Thr Glu Arg Asp Ala Leu 965 970 975 His Asn Leu Cys Gly Gly 980
<210> SEQ ID NO 79 <211> LENGTH: 2949 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-046 DNA
sequence <400> SEQUENCE: 79 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtcg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaaggtggc ggcggatcag
gtgggggtgg atcaggcggt 2880 ggaggttccg gtggcggggg atcagcctgc
accgagcggg acgccctgca caacctgtgc 2940 ggcgggtga 2949 <210>
SEQ ID NO 80 <211> LENGTH: 1000 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-047 amino
acid sequence <400> SEQUENCE: 80 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380
Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385
390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val
Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu
Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro
Phe Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp Lys Thr His Thr Cys 465 470 475 480 Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 485 490 495 Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 500 505
510 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
515 520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu 545 550 555 560 Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys 565 570 575 Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600 605 Arg Asp Glu
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 610 615 620 Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 625 630
635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly 645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala Leu His Asn 675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly Lys Gly Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 705 710 715 720 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Cys Thr Glu Arg 725 730 735 Trp Ala
Leu His Asn Leu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 740 745 750
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 755
760 765 Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala 770 775 780 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro 785 790 795 800 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val 805 810 815 Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val 820 825 830 Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 835 840 845 Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 850 855 860 Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 865 870 875
880 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
885 890 895 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr 900 905 910 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser 915 920 925 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr 930 935 940 Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr 945 950 955 960 Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 965 970 975 Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 980 985 990 Ser
Leu Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 81
<211> LENGTH: 3003 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-047 DNA sequence
<400> SEQUENCE: 81 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctggga
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtcga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggcggtg gcggttcagg tggaggaggg tcaggcggtg
gtggatccgg cgggggcgga 2160 tccggtggcg gagggtcagg cggtggcgga
tcagcctgca ccgagcggtg ggccctgcac 2220 aacctgtgcg gtggcggtgg
ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg 2280 ggtggatcag
gcggtggagg ttccggtggc gggggatccg acaaaactca cacatgccca 2340
ccgtgcccag caccggaact cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc
2400 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt
ggacgtgagc 2460 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg
gcgtggaggt gcataatgcc 2520 aagacaaagc cgcgggagga gcagtacaac
agcacgtacc gtgtggtcag cgtcctcacc 2580 gtcctgcacc aggactggct
gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 2640 ctcccagccc
ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 2700
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc
2760 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa
tgggcagccg 2820 gagaacaact acaagaccac gcctcccgtg ttggactccg
acggctcctt cttcctctac 2880 agcaagctca ccgtggacaa gagcaggtgg
cagcagggga acgtcttctc atgctccgtg 2940 atgcatgagg ctctgcacaa
ccactacacg cagaagagcc tctccctgtc tccgggtaaa 3000 tga 3003
<210> SEQ ID NO 82 <400> SEQUENCE: 82 000 <210>
SEQ ID NO 83 <400> SEQUENCE: 83 000 <210> SEQ ID NO 84
<211> LENGTH: 1000 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-048 amino
acid sequence. <400> SEQUENCE: 84 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Cys Thr Glu Arg 725 730 735 Met Ala Leu His Asn Leu Cys Gly Gly
Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly Gly Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775 780 Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 785 790 795 800
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 805
810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895 Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900 905 910 Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 915 920 925
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 930
935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu Ser Leu Ser Pro Gly Lys
995 1000 <210> SEQ ID NO 85 <211> LENGTH: 3003
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence of FVII-048 <400> SEQUENCE: 85
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380
gggggtggat caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc
1440 ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt
ccccccaaaa 1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca
catgcgtggt ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac
tggtacgtgg acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga
ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc
accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca
1800 caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt
cagcctgacc 1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg
agtgggagag caatgggcag 1920 ccggagaaca actacaagac cacgcctccc
gtgttggact ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga
caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg
aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 2100
aaaggcggtg gcggttcagg tggaggaggg tcaggcggtg gtggatccgg cgggggcgga
2160 tccggtggcg gagggtcagg cggtggcgga tcagcctgca ccgagcggat
ggccctgcac 2220 aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg
gtggcggcgg atcaggtggg 2280 ggtggatcag gcggtggagg ttccggtggc
gggggatccg acaaaactca cacatgccca 2340 ccgtgcccag caccggaact
cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc 2400 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 2460
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
2520 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 2580 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 2640 ctcccagccc ccatcgagaa aaccatctcc
aaagccaaag ggcagccccg agaaccacag 2700 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 2760 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2820
gagaacaact acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac
2880 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 2940 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaaa 3000 tga 3003 <210> SEQ ID NO 86
<211> LENGTH: 1000 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-049 amino acid
sequence <400> SEQUENCE: 86 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680
685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 705 710 715 720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Cys Thr Glu Arg 725 730 735 Asp Ala Leu His Asn Leu Cys Gly Gly
Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760 765 Gly Gly Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 770 775 780 Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 785 790 795 800
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 805
810 815 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val 820 825 830 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln 850 855 860 Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala 865 870 875 880 Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885 890 895 Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 900 905 910 Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 915 920 925
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 930
935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe 965 970 975 Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys
980 985 990 Ser Leu Ser Leu Ser Pro Gly Lys 995 1000 <210>
SEQ ID NO 87 <211> LENGTH: 3003 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: DNA sequence of
FVII-049 <400> SEQUENCE: 87 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctggga
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtcga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggcggtg gcggttcagg tggaggaggg tcaggcggtg
gtggatccgg cgggggcgga 2160 tccggtggcg gagggtcagg cggtggcgga
tcagcctgca ccgagcggga cgccctgcac 2220 aacctgtgcg gtggcggtgg
ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg 2280 ggtggatcag
gcggtggagg ttccggtggc gggggatccg acaaaactca cacatgccca 2340
ccgtgcccag caccggaact cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc
2400 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt
ggacgtgagc 2460 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg
gcgtggaggt gcataatgcc 2520 aagacaaagc cgcgggagga gcagtacaac
agcacgtacc gtgtggtcag cgtcctcacc 2580 gtcctgcacc aggactggct
gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 2640 ctcccagccc
ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 2700
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc
2760 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa
tgggcagccg 2820 gagaacaact acaagaccac gcctcccgtg ttggactccg
acggctcctt cttcctctac 2880 agcaagctca ccgtggacaa gagcaggtgg
cagcagggga acgtcttctc atgctccgtg 2940 atgcatgagg ctctgcacaa
ccactacacg cagaagagcc tctccctgtc tccgggtaaa 3000 tga 3003
<210> SEQ ID NO 88 <211> LENGTH: 948 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-011 amino
acid sequence <400> SEQUENCE: 88 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660
665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn 675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
Gly Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly 705 710 715 720 Ser Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 755 760 765 His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 770 775 780
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 785
790 795 800 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn 805 810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 865 870 875 880 Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885 890 895 Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 900 905
910 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
915 920 925 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu 930 935 940 Ser Pro Gly Lys 945 <210> SEQ ID NO 89
<211> LENGTH: 2847 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-011 DNA sequence
<400> SEQUENCE: 89 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctgggc
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg
gaggttccgg tggcggggga 2160 tcagacaaaa ctcacacatg cccaccgtgc
ccagcacctg aactcctggg aggaccgtca 2220 gtcttcctct tccccccaaa
acccaaggac accctcatga tctcccggac ccctgaggtc 2280 acatgcgtgg
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 2340
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg
2400 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg
caaggagtac 2460 aagtgcaagg tctccaacaa agccctccca gcccccatcg
agaaaaccat ctccaaagcc 2520 aaagggcagc cccgagaacc acaggtgtac
accctgcccc catcccgcga tgagctgacc 2580 aagaaccagg tcagcctgac
ctgcctggtc aaaggcttct atcccagcga catcgccgtg 2640 gagtgggaga
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgttggac 2700
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag
2760 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta
cacgcagaag 2820 agcctctccc tgtctccggg taaatga 2847 <210> SEQ
ID NO 90 <211> LENGTH: 1457 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: B domain deleted FVIII
amino acid sequence <400> SEQUENCE: 90 Met Gln Ile Glu Leu
Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys Phe Ser
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30 Trp
Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35 40
45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val
50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe
Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly
Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val Ile Thr
Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His Ala Val
Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu Tyr Asp
Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys Val Phe
Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155 160 Lys
Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165 170
175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile
180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu
Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val
Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys Asn Ser
Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg Ala Trp
Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg Ser Leu
Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr Trp His
Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280 285 Phe
Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 290 295
300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met
305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser
His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser
Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn Glu Glu
Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu Met Asp
Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe Ile Gln
Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385 390 395 400
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405
410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu
Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val
Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu
Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr
Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn
Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr
Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val
Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530
535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu
Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile
Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met
Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu
Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu
Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro Glu Phe Gln
Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630 635 640 Phe
Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 645 650
655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe
660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr
Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser
Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys His Asn Ser
Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu Leu Lys Val
Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr Glu Asp Ser
Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750 Asn Asn Ala
Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 755 760 765 Lys
Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 770 775
780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu
785 790 795 800 Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro
Arg Ser Phe 805 810 815 Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala
Val Glu Arg Leu Trp 820 825 830 Asp Tyr Gly Met Ser Ser Ser Pro His
Val Leu Arg Asn Arg Ala Gln 835 840 845 Ser Gly Ser Val Pro Gln Phe
Lys Lys Val Val Phe Gln Glu Phe Thr 850 855 860 Asp Gly Ser Phe Thr
Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 865 870 875 880 Leu Gly
Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 885 890 895
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 900
905 910 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro
Arg 915 920 925 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe
Trp Lys Val 930 935 940 Gln His His Met Ala Pro Thr Lys Asp Glu Phe
Asp Cys Lys Ala Trp 945 950 955 960 Ala Tyr Phe Ser Asp Val Asp Leu
Glu Lys Asp Val His Ser Gly Leu 965 970 975 Ile Gly Pro Leu Leu Val
Cys His Thr Asn Thr Leu Asn Pro Ala His 980 985 990 Gly Arg Gln Val
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 995 1000 1005 Asp
Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 1010 1015
1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys
1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met
Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg
Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser Asn Glu Asn
Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val Phe Thr Val
Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu Tyr Asn Leu
Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110 Leu Pro Ser
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115 1120 1125 Glu
His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser 1130 1135
1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg
1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp
Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile
Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser Trp Ile Lys
Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His Gly Ile Lys
Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser Leu Tyr Ile
Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230 Gly Lys Lys
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235 1240 1245 Met
Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn 1250 1255
1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro
1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu
Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly
Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser Asp Ala Gln Ile Thr Ala
Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met Phe Ala Thr Trp Ser Pro
Ser Lys Ala Arg Leu His Leu Gln 1325 1330 1335 Gly Arg Ser Asn Ala
Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1340 1345 1350 Trp Leu Gln
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1355 1360 1365 Thr
Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys 1370 1375
1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu
1385 1390 1395 Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn
Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro
Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu Arg Ile His Pro Gln Ser
Trp Val His Gln Ile Ala 1430 1435 1440 Leu Arg Met Glu Val Leu Gly
Cys Glu Ala Gln Asp Leu Tyr 1445 1450 1455 <210> SEQ ID NO 91
<211> LENGTH: 2351 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: Full length FVIII amino
acid sequence <400> SEQUENCE: 91 Met Gln Ile Glu Leu Ser Thr
Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys Phe Ser Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30 Trp Asp Tyr
Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35 40 45 Phe
Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 50 55
60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr
Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys
Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His Ala Val Gly Val
Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu Tyr Asp Asp Gln
Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys Val Phe Pro Gly
Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155 160 Lys Glu Asn
Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165 170 175 Tyr
Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185
190
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 195
200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu
Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln
Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg Ala Trp Pro Lys Met
His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg Ser Leu Pro Gly Leu
Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr Trp His Val Ile Gly
Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280 285 Phe Leu Glu Gly
His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 290 295 300 Leu Glu
Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 305 310 315
320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His
325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu
Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp
Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu Met Asp Val Val Arg
Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe Ile Gln Ile Arg Ser
Val Ala Lys Lys His Pro Lys Thr 385 390 395 400 Trp Val His Tyr Ile
Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405 410 415 Leu Val Leu
Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 420 425 430 Asn
Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440
445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu
450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp
Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro
Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr Asp Val Arg Pro Leu
Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val Lys His Leu Lys Asp
Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525 Lys Tyr Lys Trp Thr
Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530 535 540 Pro Arg Cys
Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 545 550 555 560
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565
570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp 610 615 620 Pro Glu Phe Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val 625 630 635 640 Phe Asp Ser Leu Gln Leu
Ser Val Cys Leu His Glu Val Ala Tyr Trp 645 650 655 Tyr Ile Leu Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 660 665 670 Ser Gly
Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690
695 700 Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly 705 710 715 720 Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys
Asn Thr Gly Asp 725 730 735 Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys 740 745 750 Asn Asn Ala Ile Glu Pro Arg Ser
Phe Ser Gln Asn Ser Arg His Pro 755 760 765 Ser Thr Arg Gln Lys Gln
Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 770 775 780 Ile Glu Lys Thr
Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 785 790 795 800 Ile
Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 805 810
815 Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr
820 825 830 Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser
Asn Asn 835 840 845 Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu
His His Ser Gly 850 855 860 Asp Met Val Phe Thr Pro Glu Ser Gly Leu
Gln Leu Arg Leu Asn Glu 865 870 875 880 Lys Leu Gly Thr Thr Ala Ala
Thr Glu Leu Lys Lys Leu Asp Phe Lys 885 890 895 Val Ser Ser Thr Ser
Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 900 905 910 Leu Ala Ala
Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 915 920 925 Pro
Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 930 935
940 Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu
945 950 955 960 Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn
Ser Gln Glu 965 970 975 Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu
Ser Gly Arg Leu Phe 980 985 990 Lys Gly Lys Arg Ala His Gly Pro Ala
Leu Leu Thr Lys Asp Asn Ala 995 1000 1005 Leu Phe Lys Val Ser Ile
Ser Leu Leu Lys Thr Asn Lys Thr Ser 1010 1015 1020 Asn Asn Ser Ala
Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser 1025 1030 1035 Leu Leu
Ile Glu Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu 1040 1045 1050
Ser Asp Thr Glu Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg 1055
1060 1065 Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg Leu Asn His
Met 1070 1075 1080 Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met
Val Gln Gln 1085 1090 1095 Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala
Gln Asn Pro Asp Met 1100 1105 1110 Ser Phe Phe Lys Met Leu Phe Leu
Pro Glu Ser Ala Arg Trp Ile 1115 1120 1125 Gln Arg Thr His Gly Lys
Asn Ser Leu Asn Ser Gly Gln Gly Pro 1130 1135 1140 Ser Pro Lys Gln
Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu 1145 1150 1155 Gly Gln
Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys 1160 1165 1170
Gly Glu Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro 1175
1180 1185 Ser Ser Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His
Glu 1190 1195 1200 Asn Asn Thr His Asn Gln Glu Lys Lys Ile Gln Glu
Glu Ile Glu 1205 1210 1215 Lys Lys Glu Thr Leu Ile Gln Glu Asn Val
Val Leu Pro Gln Ile 1220 1225 1230 His Thr Val Thr Gly Thr Lys Asn
Phe Met Lys Asn Leu Phe Leu 1235 1240 1245 Leu Ser Thr Arg Gln Asn
Val Glu Gly Ser Tyr Asp Gly Ala Tyr 1250 1255 1260 Ala Pro Val Leu
Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn 1265 1270 1275 Arg Thr
Lys Lys His Thr Ala His Phe Ser Lys Lys Gly Glu Glu 1280 1285 1290
Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu 1295
1300 1305 Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln
Gln 1310 1315 1320 Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys
Gln Phe Arg 1325 1330 1335 Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys
Arg Ile Ile Val Asp 1340 1345 1350 Asp Thr Ser Thr Gln Trp Ser Lys
Asn Met Lys His Leu Thr Pro 1355 1360 1365 Ser Thr Leu Thr Gln Ile
Asp Tyr Asn Glu Lys Glu Lys Gly Ala 1370 1375 1380 Ile Thr Gln Ser
Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser 1385 1390 1395 Ile Pro
Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser 1400 1405 1410
Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe 1415
1420 1425 Gln Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys
Lys 1430 1435 1440 Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln
Gly Ala Lys 1445 1450 1455 Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr
Leu Glu Met Thr Gly 1460 1465 1470 Asp Gln Arg Glu Val Gly Ser Leu
Gly Thr Ser Ala Thr Asn Ser 1475 1480 1485 Val Thr Tyr Lys Lys Val
Glu Asn Thr Val Leu Pro Lys Pro Asp
1490 1495 1500 Leu Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys
Val His 1505 1510 1515 Ile Tyr Gln Lys Asp Leu Phe Pro Thr Glu Thr
Ser Asn Gly Ser 1520 1525 1530 Pro Gly His Leu Asp Leu Val Glu Gly
Ser Leu Leu Gln Gly Thr 1535 1540 1545 Glu Gly Ala Ile Lys Trp Asn
Glu Ala Asn Arg Pro Gly Lys Val 1550 1555 1560 Pro Phe Leu Arg Val
Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser 1565 1570 1575 Lys Leu Leu
Asp Pro Leu Ala Trp Asp Asn His Tyr Gly Thr Gln 1580 1585 1590 Ile
Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu Lys 1595 1600
1605 Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys
1610 1615 1620 Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln
Asn Lys 1625 1630 1635 Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly
Arg Thr Glu Arg 1640 1645 1650 Leu Cys Ser Gln Asn Pro Pro Val Leu
Lys Arg His Gln Arg Glu 1655 1660 1665 Ile Thr Arg Thr Thr Leu Gln
Ser Asp Gln Glu Glu Ile Asp Tyr 1670 1675 1680 Asp Asp Thr Ile Ser
Val Glu Met Lys Lys Glu Asp Phe Asp Ile 1685 1690 1695 Tyr Asp Glu
Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 1700 1705 1710 Thr
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 1715 1720
1725 Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser
1730 1735 1740 Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu
Phe Thr 1745 1750 1755 Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly
Glu Leu Asn Glu 1760 1765 1770 His Leu Gly Leu Leu Gly Pro Tyr Ile
Arg Ala Glu Val Glu Asp 1775 1780 1785 Asn Ile Met Val Thr Phe Arg
Asn Gln Ala Ser Arg Pro Tyr Ser 1790 1795 1800 Phe Tyr Ser Ser Leu
Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 1805 1810 1815 Ala Glu Pro
Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr 1820 1825 1830 Tyr
Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 1835 1840
1845 Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu
1850 1855 1860 Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val
Cys His 1865 1870 1875 Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln
Val Thr Val Gln 1880 1885 1890 Glu Phe Ala Leu Phe Phe Thr Ile Phe
Asp Glu Thr Lys Ser Trp 1895 1900 1905 Tyr Phe Thr Glu Asn Met Glu
Arg Asn Cys Arg Ala Pro Cys Asn 1910 1915 1920 Ile Gln Met Glu Asp
Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 1925 1930 1935 Ala Ile Asn
Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met 1940 1945 1950 Ala
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 1955 1960
1965 Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr
1970 1975 1980 Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn
Leu Tyr 1985 1990 1995 Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro
Ser Lys Ala Gly 2000 2005 2010 Ile Trp Arg Val Glu Cys Leu Ile Gly
Glu His Leu His Ala Gly 2015 2020 2025 Met Ser Thr Leu Phe Leu Val
Tyr Ser Asn Lys Cys Gln Thr Pro 2030 2035 2040 Leu Gly Met Ala Ser
Gly His Ile Arg Asp Phe Gln Ile Thr Ala 2045 2050 2055 Ser Gly Gln
Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His 2060 2065 2070 Tyr
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser 2075 2080
2085 Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile
2090 2095 2100 Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr
Ile Ser 2105 2110 2115 Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys
Lys Trp Gln Thr 2120 2125 2130 Tyr Arg Gly Asn Ser Thr Gly Thr Leu
Met Val Phe Phe Gly Asn 2135 2140 2145 Val Asp Ser Ser Gly Ile Lys
His Asn Ile Phe Asn Pro Pro Ile 2150 2155 2160 Ile Ala Arg Tyr Ile
Arg Leu His Pro Thr His Tyr Ser Ile Arg 2165 2170 2175 Ser Thr Leu
Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 2180 2185 2190 Ser
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln 2195 2200
2205 Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser
2210 2215 2220 Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn
Ala Trp 2225 2230 2235 Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu
Gln Val Asp Phe 2240 2245 2250 Gln Lys Thr Met Lys Val Thr Gly Val
Thr Thr Gln Gly Val Lys 2255 2260 2265 Ser Leu Leu Thr Ser Met Tyr
Val Lys Glu Phe Leu Ile Ser Ser 2270 2275 2280 Ser Gln Asp Gly His
Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 2285 2290 2295 Val Lys Val
Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 2300 2305 2310 Asn
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 2315 2320
2325 Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu
2330 2335 2340 Gly Cys Glu Ala Gln Asp Leu Tyr 2345 2350
<210> SEQ ID NO 92 <211> LENGTH: 461 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FIX amino acid
sequence <400> SEQUENCE: 92 Met Gln Arg Val Asn Met Ile Met
Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr
Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn
Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly
Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65
70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys
Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly
Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile
Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp
Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu
Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro
Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185
190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
Asp Phe 210 215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly
Gln Phe Pro Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp
Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val
Thr Ala Ala His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val
Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu
Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr
Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310
315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys
Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly
Arg Ser Ala Leu Val
355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys
Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys Gln Gly
Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly Thr Ser
Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys Ala Met
Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg Tyr Val
Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 450 455 460 <210> SEQ
ID NO 93 <211> LENGTH: 1384 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FIX DNA sequence
<400> SEQUENCE: 93 atgcagcgcg tgaacatgat catggcagaa
tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac tcagtgctga
atgtacagtt tttcttgatc atgaaaacgc acaaaattct 120 gaatcggcca
aagaggtata attcaggtaa attggaagag tttgttcaag ggaatctaga 180
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt ttgaaaacac
240 tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg
agtccaatcc 300 atgtttaaat ggcggcagtt gcaaggatga cattaattcc
tatgaatgtt ggtgtccctt 360 tggatttgaa ggaaagaact gtgaattaga
tgtaacatgt aacattaaga atggcagatg 420 cgagcagttt tgtaaaaata
gtgctgataa caaggtggtt tgctcctgta ctgagggata 480 tcgacttgca
gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 540
ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg atgtggacta
600 tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca
cccaatcatt 660 taatgacttc actcgggttg ttggtggaga agatgccaaa
ccaggtcaat tcccttggca 720 ggttgttttg aatggtaaag ttgatgcatt
ctgtggaggc tctatcgtta atgaaaaatg 780 gattgtaact gctgcccact
gtgttgaaac tggtgttaaa attacagttg tcgcaggtga 840 acataatatt
gaggagacag aacatacaga gcaaaagcga aatgtgattc gaattattcc 900
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc ttctggaact
960 ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg
acaaggaata 1020 cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt
ggctggggaa gagtcttcca 1080 caaagggaga tcagctttag ttcttcagta
ccttagagtt ccacttgttg accgagccac 1140 atgtcttcga tctacaaagt
tcaccatcta taacaacatg ttctgtgctg gcttccatga 1200 aggaggtaga
gattcatgtc aaggagatag tgggggaccc catgttactg aagtggaagg 1260
gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga aaggcaaata
1320 tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa
caaagctcac 1380 ttga 1384 <210> SEQ ID NO 94 <211>
LENGTH: 488 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FX amino acid sequence <400> SEQUENCE:
94 Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly
1 5 10 15 Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln
Ala Asn 20 25 30 Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe
Leu Glu Glu Met 35 40 45 Lys Lys Gly His Leu Glu Arg Glu Cys Met
Glu Glu Thr Cys Ser Tyr 50 55 60 Glu Glu Ala Arg Glu Val Phe Glu
Asp Ser Asp Lys Thr Asn Glu Phe 65 70 75 80 Trp Asn Lys Tyr Lys Asp
Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 85 90 95 Asn Gln Gly Lys
Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 100 105 110 Leu Glu
Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 115 120 125
Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 130
135 140 Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp
Asn 145 150 155 160 Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys
Gly Lys Gln Thr 165 170 175 Leu Glu Arg Arg Lys Arg Ser Val Ala Gln
Ala Thr Ser Ser Ser Gly 180 185 190 Glu Ala Pro Asp Ser Ile Thr Trp
Lys Pro Tyr Asp Ala Ala Asp Leu 195 200 205 Asp Pro Thr Glu Asn Pro
Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 210 215 220 Pro Glu Arg Gly
Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 225 230 235 240 Cys
Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 245 250
255 Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu
260 265 270 Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val
Arg Val 275 280 285 Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu
Ala Val His Glu 290 295 300 Val Glu Val Val Ile Lys His Asn Arg Phe
Thr Lys Glu Thr Tyr Asp 305 310 315 320 Phe Asp Ile Ala Val Leu Arg
Leu Lys Thr Pro Ile Thr Phe Arg Met 325 330 335 Asn Val Ala Pro Ala
Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 340 345 350 Leu Met Thr
Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 355 360 365 Glu
Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 370 375
380 Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln
385 390 395 400 Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp
Ala Cys Gln 405 410 415 Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe
Lys Asp Thr Tyr Phe 420 425 430 Val Thr Gly Ile Val Ser Trp Gly Glu
Gly Cys Ala Arg Lys Gly Lys 435 440 445 Tyr Gly Ile Tyr Thr Lys Val
Thr Ala Phe Leu Lys Trp Ile Asp Arg 450 455 460 Ser Met Lys Thr Arg
Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 465 470 475 480 Val Ile
Thr Ser Ser Pro Leu Lys 485 <210> SEQ ID NO 95 <211>
LENGTH: 1467 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FX DNA sequence <400> SEQUENCE: 95
atggggcgcc cactgcacct cgtcctgctc agtgcctccc tggctggcct cctgctgctc
60 ggggaaagtc tgttcatccg cagggagcag gccaacaaca tcctggcgag
ggtcacgagg 120 gccaattcct ttcttgaaga gatgaagaaa ggacacctcg
aaagagagtg catggaagag 180 acctgctcat acgaagaggc ccgcgaggtc
tttgaggaca gcgacaagac gaatgaattc 240 tggaataaat acaaagatgg
cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa 300 tgtaaagacg
gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac 360
tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc
420 cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct
ggctgacaac 480 ggcaaggcct gcattcccac agggccctac ccctgtggga
aacagaccct ggaacgcagg 540 aagaggtcag tggcccaggc caccagcagc
agcggggagg cccctgacag catcacatgg 600 aagccatatg atgcagccga
cctggacccc accgagaacc ccttcgacct gcttgacttc 660 aaccagacgc
agcctgagag gggcgacaac aacctcacca ggatcgtggg aggccaggaa 720
tgcaaggacg gggagtgtcc ctggcaggcc ctgctcatca atgaggaaaa cgagggtttc
780 tgtggtggaa ccattctgag cgagttctac atcctaacgg cagcccactg
tctctaccaa 840 gccaagagat tcaaggtgag ggtaggggac cggaacacgg
agcaggagga gggcggtgag 900 gcggtgcacg aggtggaggt ggtcatcaag
cacaaccggt tcacaaagga gacctatgac 960 ttcgacatcg ccgtgctccg
gctcaagacc cccatcacct tccgcatgaa cgtggcgcct 1020 gcctgcctcc
ccgagcgtga ctgggccgag tccacgctga tgacgcagaa gacggggatt 1080
gtgagcggct tcgggcgcac ccacgagaag ggccggcagt ccaccaggct caagatgctg
1140 gaggtgccct acgtggaccg caacagctgc aagctgtcca gcagcttcat
catcacccag 1200 aacatgttct gtgccggcta cgacaccaag caggaggatg
cctgccaggg ggacagcggg 1260 ggcccgcacg tcacccgctt caaggacacc
tacttcgtga caggcatcgt cagctgggga 1320 gagggctgtg cccgtaaggg
gaagtacggg atctacacca aggtcaccgc cttcctcaag 1380 tggatcgaca
ggtccatgaa aaccaggggc ttgcccaagg ccaagagcca tgccccggag 1440
gtcataacgt cctctccatt aaagtga 1467 <210> SEQ ID NO 96
<211> LENGTH: 3813 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence of
FVII-066
<400> SEQUENCE: 96 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg
600 gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg
ggggaccctg 660 atcaacacca tctgggtggt ctccgcggcc cactgtttcg
acaaaatcaa gaactggagg 720 aacctgatcg cggtgctggg cgagcacgac
ctcagcgagc acgacgggga tgagcagagc 780 cggcgggtgg cgcaggtcat
catccccagc acgtacgtcc cgggcaccac caaccacgac 840 atcgcgctgc
tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc 900
ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc
960 ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt
cctcaacgtg 1020 ccccggctga tgacccagga ctgcctgcag cagtcacgga
aggtgggaga ctccccaaat 1080 atcacggagt acatgttctg tgccggctac
tcggatggca gcaaggactc ctgcaagggg 1140 gacagtggag gcccacatgc
cacccactac cggggcacgt ggtacctgac gggcatcgtc 1200 agctggggcc
agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1260
tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga
1320 gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg
cggatcaggt 1380 gggggtggat caggcggtgg aggttccggt ggcgggggat
ccgacaaaac tcacacatgc 1440 ccaccgtgcc cagctccgga actcctggga
ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag
accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc
1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt
ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca
aagggcagcc ccgagaacca 1800 caggtgtaca ccctgccccc atcccgggat
gagctgacca agaaccaggt cagcctgacc 1860 tgcctggtca aaggcttcta
tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca
actacaagac cacgcctccc gtgttggact ccgacggctc cttcttcctc 1980
tacagcaagc tcaccgtcga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc
2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct
gtctccgggt 2100 aaacggcgcc gccggagcgg tggcggcgga tcaggtgggg
gtggatcagg cggtggaggt 2160 tccggtggcg ggggatccgg cggtggaggt
tccggtgggg gtggatcaag gaagaggagg 2220 aagagggcgc aggtgcagct
gcaggagtct gggggaggct tggtacagcc tggggggtcc 2280 ctgagactct
cctgtgcagc ctctggattc atgtttagca ggtatgccat gagctgggtc 2340
cgccaggctc cagggaaggg gccagagtgg gtctcaggta ttagtggtag tggtggtagt
2400 acatactacg cagactccgt gaagggccgg ttcaccgtct ccagagacaa
ttccaagaac 2460 acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca
cggctgtata ttactgcgcc 2520 cggggcgcca cctacaccag ccggagcgac
gtgcccgacc agaccagctt cgactactgg 2580 ggccagggaa ccctggtcac
cgtctcctca gggagtgcat ccgccccaaa gcttgaagaa 2640 ggtgaatttt
cagaagcacg cgtatctgaa ctgactcagg accctgctgt gtctgtggcc 2700
ttgggacaga cagtcaggat cacatgccaa ggagacagcc tcagaaactt ttatgcaagc
2760 tggtaccagc agaagccagg acaggcccct actcttgtca tctatggttt
aagtaaaagg 2820 ccctcaggga tcccagaccg attctctgcc tccagctcag
gaaacacagc ttccttgacc 2880 atcactgggg ctcaggcgga agatgaggct
gactattact gcctgctgta ctacggcggc 2940 ggccagcagg gcgtgttcgg
cggcggcacc aagctgaccg tcctacgtca gcccaaggct 3000 gccccctcgg
tcactctgtt cccgccctct tctgcggccg gtggcggtgg ctccggcgga 3060
ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg ttccggtggc
3120 gggggatcag acaaaactca cacatgccca ccgtgcccag caccggaact
cctgggcgga 3180 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc
tcatgatctc ccggacccct 3240 gaggtcacat gcgtggtggt ggacgtgagc
cacgaagacc ctgaggtcaa gttcaactgg 3300 tacgtggacg gcgtggaggt
gcataatgcc aagacaaagc cgcgggagga gcagtacaac 3360 agcacgtacc
gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 3420
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc
3480 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc
ccgggatgag 3540 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag
gcttctatcc cagcgacatc 3600 gccgtggagt gggagagcaa tgggcagccg
gagaacaact acaagaccac gcctcccgtg 3660 ttggactccg acggctcctt
cttcctctac agcaagctca ccgtggacaa gagcaggtgg 3720 cagcagggga
acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 3780
cagaagagcc tctccctgtc tccgggtaaa tga 3813 <210> SEQ ID NO 97
<211> LENGTH: 1270 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-066 amino acid
sequence <400> SEQUENCE: 97 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr
His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555
560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys 580 585 590
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595
600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg 690 695 700 Arg Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 705 710 715
720 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
725 730 735 Arg Lys Arg Arg Lys Arg Ala Gln Val Gln Leu Gln Glu Ser
Gly Gly 740 745 750 Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser
Cys Ala Ala Ser 755 760 765 Gly Phe Met Phe Ser Arg Tyr Ala Met Ser
Trp Val Arg Gln Ala Pro 770 775 780 Gly Lys Gly Pro Glu Trp Val Ser
Gly Ile Ser Gly Ser Gly Gly Ser 785 790 795 800 Thr Tyr Tyr Ala Asp
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp 805 810 815 Asn Ser Lys
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 820 825 830 Asp
Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr Thr Ser Arg 835 840
845 Ser Asp Val Pro Asp Gln Thr Ser Phe Asp Tyr Trp Gly Gln Gly Thr
850 855 860 Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys Leu
Glu Glu 865 870 875 880 Gly Glu Phe Ser Glu Ala Arg Val Ser Glu Leu
Thr Gln Asp Pro Ala 885 890 895 Val Ser Val Ala Leu Gly Gln Thr Val
Arg Ile Thr Cys Gln Gly Asp 900 905 910 Ser Leu Arg Asn Phe Tyr Ala
Ser Trp Tyr Gln Gln Lys Pro Gly Gln 915 920 925 Ala Pro Thr Leu Val
Ile Tyr Gly Leu Ser Lys Arg Pro Ser Gly Ile 930 935 940 Pro Asp Arg
Phe Ser Ala Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 945 950 955 960
Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu 965
970 975 Tyr Tyr Gly Gly Gly Gln Gln Gly Val Phe Gly Gly Gly Thr Lys
Leu 980 985 990 Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr
Leu Phe Pro 995 1000 1005 Pro Ser Ser Ala Ala Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 1010 1015 1020 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 1025 1030 1035 Gly Gly Gly Gly Ser Asp
Lys Thr His Thr Cys Pro Pro Cys Pro 1040 1045 1050 Ala Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 1055 1060 1065 Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 1070 1075 1080
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 1085
1090 1095 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 1100 1105 1110 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val 1115 1120 1125 Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys 1130 1135 1140 Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr 1145 1150 1155 Ile Ser Lys Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr 1160 1165 1170 Leu Pro Pro Ser
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 1175 1180 1185 Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 1190 1195 1200
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 1205
1210 1215 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu 1220 1225 1230 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 1235 1240 1245 Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser 1250 1255 1260 Leu Ser Leu Ser Pro Gly Lys 1265
1270 <210> SEQ ID NO 98 <211> LENGTH: 3012 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-057 <400> SEQUENCE: 98 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatcc 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggagg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcaagcg
tgagccagac cagcaagctg acccggattg tggggggcaa ggtgtgcccc 1500
aaaggggagt gtccatggca ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg
1560 accctgatca acaccatctg ggtggtctcc gcggcccact gtttcgacaa
aatcaagaac 1620 tggaggaacc tgatcgcggt gctgggcgag cacgacctca
gcgagcacga cggggatgag 1680 cagagccggc gggtggcgca ggtcatcatc
cccagcacgt acgtcccggg caccaccaac 1740 cacgacatcg cgctgctccg
cctgcaccag cccgtggtcc tcactgacca tgtggtgccc 1800 ctctgcctgc
ccgaacggac gttctctgag aggacgctgg ccttcgtgcg cttctcattg 1860
gtcagcggct ggggccagct gctggaccgt ggcgccacgg ccctggagct catggtcctc
1920 aacgtgcccc ggctgatgac ccaggactgc ctgcagcagt cacggaaggt
gggagactcc 1980 ccaaatatca cggagtacat gttctgtgcc ggctactcgg
atggcagcaa ggactcctgc 2040 aagggggaca gtggaggccc acatgccacc
cactaccggg gcacgtggta cctgacgggc 2100 atcgtcagct ggggccaggg
ctgcgcaacc gtgggccact ttggggtgta caccagggtc 2160 tcccagtaca
tcgagtggct gcaaaagctc atgcgctcag agccacgccc aggagtcctc 2220
ctgcgagccc catttcccgg tggcggtggc tccggcggag gtgggtccgg tggcggcgga
2280 tcaggtgggg gtggatcagg cggtggaggt tccggtggcg ggggatcaga
caaaactcac 2340 acatgcccac cgtgcccagc acctgaactc ctgggaggac
cgtcagtctt cctcttcccc 2400 ccaaaaccca aggacaccct catgatctcc
cggacccctg aggtcacatg cgtggtggtg 2460 gacgtgagcc acgaagaccc
tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 2520 cataatgcca
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 2580
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc
2640 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg
gcagccccga 2700 gaaccacagg tgtacaccct gcccccatcc cgggatgagc
tgaccaagaa ccaggtcagc 2760 ctgacctgcc tggtcaaagg cttctatccc
agcgacatcg ccgtggagtg ggagagcaat 2820 gggcagccgg agaacaacta
caagaccacg cctcccgtgt tggactccga cggctccttc 2880 ttcctctaca
gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 2940
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct
3000 ccgggtaaat ga 3012 <210> SEQ ID NO 99 <211>
LENGTH: 1003 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-057 amino acid sequence <400> SEQUENCE: 99
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260
265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385
390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Ser
Val Ser Gln Thr Ser Lys Leu Thr Arg Ile Val Gly Gly 485 490 495 Lys
Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val 500 505
510 Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val
515 520 525 Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg
Asn Leu 530 535 540 Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His
Asp Gly Asp Glu 545 550 555 560 Gln Ser Arg Arg Val Ala Gln Val Ile
Ile Pro Ser Thr Tyr Val Pro 565 570 575 Gly Thr Thr Asn His Asp Ile
Ala Leu Leu Arg Leu His Gln Pro Val 580 585 590 Val Leu Thr Asp His
Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe 595 600 605 Ser Glu Arg
Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp 610 615 620 Gly
Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu 625 630
635 640 Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg
Lys 645 650 655 Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys
Ala Gly Tyr 660 665 670 Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp
Ser Gly Gly Pro His 675 680 685 Ala Thr His Tyr Arg Gly Thr Trp Tyr
Leu Thr Gly Ile Val Ser Trp 690 695 700 Gly Gln Gly Cys Ala Thr Val
Gly His Phe Gly Val Tyr Thr Arg Val 705 710 715 720 Ser Gln Tyr Ile
Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg 725 730 735 Pro Gly
Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly 740 745 750
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755
760 765 Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro
Pro 770 775 780 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro 785 790 795 800 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu Val Thr 805 810 815 Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys Phe Asn 820 825 830 Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg 835 840 845 Glu Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 850 855 860 Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 865 870 875
880 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
885 890 895 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Asp 900 905 910 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe 915 920 925 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu 930 935 940 Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe 945 950 955 960 Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 965 970 975 Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 980 985 990 Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID
NO 100 <211> LENGTH: 3012 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-058
<400> SEQUENCE: 100 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatcc 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggagg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380
ggttccggtg gcgggggatc cggcggtgga ggttccggtg ggggtggatc aggaggaggt
1440 ggttcagact tcctggccga gggcggcggc gtgcggattg tggggggcaa
ggtgtgcccc 1500 aaaggggagt gtccatggca ggtcctgttg ttggtgaatg
gagctcagtt gtgtgggggg 1560 accctgatca acaccatctg ggtggtctcc
gcggcccact gtttcgacaa aatcaagaac 1620 tggaggaacc tgatcgcggt
gctgggcgag cacgacctca gcgagcacga cggggatgag 1680 cagagccggc
gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac 1740
cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc
1800 ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg
cttctcattg 1860 gtcagcggct ggggccagct gctggaccgt ggcgccacgg
ccctggagct catggtcctc 1920 aacgtgcccc ggctgatgac ccaggactgc
ctgcagcagt cacggaaggt gggagactcc 1980 ccaaatatca cggagtacat
gttctgtgcc ggctactcgg atggcagcaa ggactcctgc 2040 aagggggaca
gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc 2100
atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc
2160 tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc
aggagtcctc 2220 ctgcgagccc catttcccgg tggcggtggc tccggcggag
gtgggtccgg tggcggcgga 2280 tcaggtgggg gtggatcagg cggtggaggt
tccggtggcg ggggatcaga caaaactcac 2340 acatgcccac cgtgcccagc
acctgaactc ctgggaggac cgtcagtctt cctcttcccc 2400 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 2460
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
2520 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 2580 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 2640 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg gcagccccga 2700 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 2760 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 2820
gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc
2880 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 2940 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012 <210> SEQ ID NO
101 <211> LENGTH: 1003 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-058 amino acid
sequence <400> SEQUENCE: 101 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Asp Phe Leu Ala Glu Gly Gly Gly
Val Arg Ile Val Gly Gly 485 490 495 Lys Val Cys Pro Lys Gly Glu Cys
Pro Trp Gln Val Leu Leu Leu Val 500 505 510 Asn Gly Ala Gln Leu Cys
Gly Gly Thr Leu Ile Asn Thr Ile Trp Val 515 520 525 Val Ser Ala Ala
His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530 535 540 Ile Ala
Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu 545 550 555
560 Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro
565 570 575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln
Pro Val 580 585 590 Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro
Glu Arg Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala Phe Val Arg Phe
Ser Leu Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu Asp Arg Gly Ala
Thr Ala Leu Glu Leu Met Val Leu 625 630 635 640 Asn Val Pro Arg Leu
Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650 655 Val Gly Asp
Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr 660 665 670 Ser
Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His 675 680
685 Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp
690 695 700 Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr
Arg Val 705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met
Arg Ser Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu Arg Ala Pro Phe
Pro Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Gly Gly
Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 770 775 780 Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 785 790 795 800
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 805
810 815 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn 820 825 830 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val 850 855 860 Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser 865 870 875 880 Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895 Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900 905 910 Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 915 920 925
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 930
935 940 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe 945 950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly 965 970 975
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 980
985 990 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 995 1000
<210> SEQ ID NO 102 <211> LENGTH: 3003 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-059 <400> SEQUENCE: 102 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatcc 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggagg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcaacca
ccaagatcaa gccccggatt gtggggggca aggtgtgccc caaaggggag 1500
tgtccatggc aggtcctgtt gttggtgaat ggagctcagt tgtgtggggg gaccctgatc
1560 aacaccatct gggtggtctc cgcggcccac tgtttcgaca aaatcaagaa
ctggaggaac 1620 ctgatcgcgg tgctgggcga gcacgacctc agcgagcacg
acggggatga gcagagccgg 1680 cgggtggcgc aggtcatcat ccccagcacg
tacgtcccgg gcaccaccaa ccacgacatc 1740 gcgctgctcc gcctgcacca
gcccgtggtc ctcactgacc atgtggtgcc cctctgcctg 1800 cccgaacgga
cgttctctga gaggacgctg gccttcgtgc gcttctcatt ggtcagcggc 1860
tggggccagc tgctggaccg tggcgccacg gccctggagc tcatggtcct caacgtgccc
1920 cggctgatga cccaggactg cctgcagcag tcacggaagg tgggagactc
cccaaatatc 1980 acggagtaca tgttctgtgc cggctactcg gatggcagca
aggactcctg caagggggac 2040 agtggaggcc cacatgccac ccactaccgg
ggcacgtggt acctgacggg catcgtcagc 2100 tggggccagg gctgcgcaac
cgtgggccac tttggggtgt acaccagggt ctcccagtac 2160 atcgagtggc
tgcaaaagct catgcgctca gagccacgcc caggagtcct cctgcgagcc 2220
ccatttcccg gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg
2280 ggtggatcag gcggtggagg ttccggtggc gggggatcag acaaaactca
cacatgccca 2340 ccgtgcccag cacctgaact cctgggagga ccgtcagtct
tcctcttccc cccaaaaccc 2400 aaggacaccc tcatgatctc ccggacccct
gaggtcacat gcgtggtggt ggacgtgagc 2460 cacgaagacc ctgaggtcaa
gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 2520 aagacaaagc
cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 2580
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc
2640 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg
agaaccacag 2700 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga
accaggtcag cctgacctgc 2760 ctggtcaaag gcttctatcc cagcgacatc
gccgtggagt gggagagcaa tgggcagccg 2820 gagaacaact acaagaccac
gcctcccgtg ttggactccg acggctcctt cttcctctac 2880 agcaagctca
ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 2940
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa
3000 tga 3003 <210> SEQ ID NO 103 <211> LENGTH: 1000
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVII-059 amino acid sequence <400> SEQUENCE: 103
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5
10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly
Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu
Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln
Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu
Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln
Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp
Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu
Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys
Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135
140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys
Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro
Gln Gly Arg Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260
265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385
390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Thr
Thr Lys Ile Lys Pro Arg Ile Val Gly Gly Lys Val Cys 485 490 495 Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala 500 505
510 Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala
515 520 525 Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala Val 530 535 540 Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu Gln Ser Arg 545 550 555 560 Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro Gly Thr Thr 565 570 575 Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val Val Leu Thr 580 585 590 Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg 595 600 605 Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu 610 615 620 Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro 625 630
635 640 Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly
Asp
645 650 655 Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser
Asp Gly 660 665 670 Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro
His Ala Thr His 675 680 685 Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile
Val Ser Trp Gly Gln Gly 690 695 700 Cys Ala Thr Val Gly His Phe Gly
Val Tyr Thr Arg Val Ser Gln Tyr 705 710 715 720 Ile Glu Trp Leu Gln
Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val 725 730 735 Leu Leu Arg
Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 740 745 750 Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 755 760
765 Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
770 775 780 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro 785 790 795 800 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val 805 810 815 Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val 820 825 830 Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln 835 840 845 Tyr Asn Ser Thr Tyr
Arg Val Val Ser Val Leu Thr Val Leu His Gln 850 855 860 Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 865 870 875 880
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 885
890 895 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr 900 905 910 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser 915 920 925 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr 930 935 940 Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr 945 950 955 960 Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 965 970 975 Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 980 985 990 Ser Leu
Ser Leu Ser Pro Gly Lys 995 1000 <210> SEQ ID NO 104
<211> LENGTH: 3012 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-060
<400> SEQUENCE: 104 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg gctccggcgg aggtgggtcc
600 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag gttccggtgg
cgggggatcc 660 gacaaaactc acacatgccc accgtgccca gctccggaac
tcctgggagg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 840 ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 900
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggatga gctgaccaag 1080 aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gttggactcc 1200 gacggctcct
tcttcctcta cagcaagctc accgtcgaca agagcaggtg gcagcagggg 1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1320 ctctccctgt ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc
aggcggtgga 1380 ggttccggtg gcgggggatc cggcggtgga ggttccggtg
ggggtggatc aggaggaggt 1440 ggttcagccc tgcggccccg ggtggtgggc
ggcgccgtgg tggggggcaa ggtgtgcccc 1500 aaaggggagt gtccatggca
ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg 1560 accctgatca
acaccatctg ggtggtctcc gcggcccact gtttcgacaa aatcaagaac 1620
tggaggaacc tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag
1680 cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg
caccaccaac 1740 cacgacatcg cgctgctccg cctgcaccag cccgtggtcc
tcactgacca tgtggtgccc 1800 ctctgcctgc ccgaacggac gttctctgag
aggacgctgg ccttcgtgcg cttctcattg 1860 gtcagcggct ggggccagct
gctggaccgt ggcgccacgg ccctggagct catggtcctc 1920 aacgtgcccc
ggctgatgac ccaggactgc ctgcagcagt cacggaaggt gggagactcc 1980
ccaaatatca cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc
2040 aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta
cctgacgggc 2100 atcgtcagct ggggccaggg ctgcgcaacc gtgggccact
ttggggtgta caccagggtc 2160 tcccagtaca tcgagtggct gcaaaagctc
atgcgctcag agccacgccc aggagtcctc 2220 ctgcgagccc catttcccgg
tggcggtggc tccggcggag gtgggtccgg tggcggcgga 2280 tcaggtgggg
gtggatcagg cggtggaggt tccggtggcg ggggatcaga caaaactcac 2340
acatgcccac cgtgcccagc acctgaactc ctgggaggac cgtcagtctt cctcttcccc
2400 ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg
cgtggtggtg 2460 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt
acgtggacgg cgtggaggtg 2520 cataatgcca agacaaagcc gcgggaggag
cagtacaaca gcacgtaccg tgtggtcagc 2580 gtcctcaccg tcctgcacca
ggactggctg aatggcaagg agtacaagtg caaggtctcc 2640 aacaaagccc
tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 2700
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc
2760 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg
ggagagcaat 2820 gggcagccgg agaacaacta caagaccacg cctcccgtgt
tggactccga cggctccttc 2880 ttcctctaca gcaagctcac cgtggacaag
agcaggtggc agcaggggaa cgtcttctca 2940 tgctccgtga tgcatgaggc
tctgcacaac cactacacgc agaagagcct ctccctgtct 3000 ccgggtaaat ga 3012
<210> SEQ ID NO 105 <211> LENGTH: 1003 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-060 amino acid sequence <400> SEQUENCE: 105 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325
330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435 440 445
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 450
455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Val Val Gly Gly Ala
Val Val Gly Gly 485 490 495 Lys Val Cys Pro Lys Gly Glu Cys Pro Trp
Gln Val Leu Leu Leu Val 500 505 510 Asn Gly Ala Gln Leu Cys Gly Gly
Thr Leu Ile Asn Thr Ile Trp Val 515 520 525 Val Ser Ala Ala His Cys
Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu 530 535 540 Ile Ala Val Leu
Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu 545 550 555 560 Gln
Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro 565 570
575 Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val
580 585 590 Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg
Thr Phe 595 600 605 Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu
Val Ser Gly Trp 610 615 620 Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala
Leu Glu Leu Met Val Leu 625 630 635 640 Asn Val Pro Arg Leu Met Thr
Gln Asp Cys Leu Gln Gln Ser Arg Lys 645 650 655 Val Gly Asp Ser Pro
Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr 660 665 670 Ser Asp Gly
Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His 675 680 685 Ala
Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp 690 695
700 Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val
705 710 715 720 Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser
Glu Pro Arg 725 730 735 Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly
Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr His Thr Cys Pro Pro 770 775 780 Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 785 790 795 800 Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 805 810 815
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 820
825 830 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg 835 840 845 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr Val 850 855 860 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser 865 870 875 880 Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys 885 890 895 Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 900 905 910 Glu Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 915 920 925 Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 930 935 940
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 945
950 955 960 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly 965 970 975 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr 980 985 990 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 995 1000 <210> SEQ ID NO 106 <211> LENGTH: 3012
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-061 <400> SEQUENCE: 106
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
ggtggcggtg gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg
gggtggatca ggcggtggag gttccggtgg cgggggatcc 660 gacaaaactc
acacatgccc accgtgccca gctccggaac tcctgggagg accgtcagtc 720
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
780 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
1140 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gttggactcc 1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca
agagcaggtg gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa
aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg
gcgggggatc cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440
ggttcagccc tgcggccccg ggtggtgggc ggcgccattg tggggggcaa ggtgtgcccc
1500 aaaggggagt gtccatggca ggtcctgttg ttggtgaatg gagctcagtt
gtgtgggggg 1560 accctgatca acaccatctg ggtggtctcc gcggcccact
gtttcgacaa aatcaagaac 1620 tggaggaacc tgatcgcggt gctgggcgag
cacgacctca gcgagcacga cggggatgag 1680 cagagccggc gggtggcgca
ggtcatcatc cccagcacgt acgtcccggg caccaccaac 1740 cacgacatcg
cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc 1800
ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg cttctcattg
1860 gtcagcggct ggggccagct gctggaccgt ggcgccacgg ccctggagct
catggtcctc 1920 aacgtgcccc ggctgatgac ccaggactgc ctgcagcagt
cacggaaggt gggagactcc 1980 ccaaatatca cggagtacat gttctgtgcc
ggctactcgg atggcagcaa ggactcctgc 2040 aagggggaca gtggaggccc
acatgccacc cactaccggg gcacgtggta cctgacgggc 2100 atcgtcagct
ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc 2160
tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc aggagtcctc
2220 ctgcgagccc catttcccgg tggcggtggc tccggcggag gtgggtccgg
tggcggcgga 2280 tcaggtgggg gtggatcagg cggtggaggt tccggtggcg
ggggatcaga caaaactcac 2340 acatgcccac cgtgcccagc acctgaactc
ctgggaggac cgtcagtctt cctcttcccc 2400 ccaaaaccca aggacaccct
catgatctcc cggacccctg aggtcacatg cgtggtggtg 2460 gacgtgagcc
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 2520
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc
2580 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg
caaggtctcc 2640 aacaaagccc tcccagcccc catcgagaaa accatctcca
aagccaaagg gcagccccga 2700 gaaccacagg tgtacaccct gcccccatcc
cgggatgagc tgaccaagaa ccaggtcagc 2760 ctgacctgcc tggtcaaagg
cttctatccc agcgacatcg ccgtggagtg ggagagcaat 2820 gggcagccgg
agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc 2880
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca
2940 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct
ctccctgtct 3000 ccgggtaaat ga 3012 <210> SEQ ID NO 107
<211> LENGTH: 1003 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-061 amino acid
sequence
<400> SEQUENCE: 107 Met Val Ser Gln Ala Leu Arg Leu Leu Cys
Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val
Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg
Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu
Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg
Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80
Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85
90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu
Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp
Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr
Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His
Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr
Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu
Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185 190 Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 195 200 205
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 210
215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330
335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435 440 445 Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 450 455
460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Val Val Gly Gly Ala Ile
Val Gly Gly 485 490 495 Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln
Val Leu Leu Leu Val 500 505 510 Asn Gly Ala Gln Leu Cys Gly Gly Thr
Leu Ile Asn Thr Ile Trp Val 515 520 525 Val Ser Ala Ala His Cys Phe
Asp Lys Ile Lys Asn Trp Arg Asn Leu 530 535 540 Ile Ala Val Leu Gly
Glu His Asp Leu Ser Glu His Asp Gly Asp Glu 545 550 555 560 Gln Ser
Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro 565 570 575
Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val 580
585 590 Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg Thr
Phe 595 600 605 Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val
Ser Gly Trp 610 615 620 Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu
Glu Leu Met Val Leu 625 630 635 640 Asn Val Pro Arg Leu Met Thr Gln
Asp Cys Leu Gln Gln Ser Arg Lys 645 650 655 Val Gly Asp Ser Pro Asn
Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr 660 665 670 Ser Asp Gly Ser
Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His 675 680 685 Ala Thr
His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp 690 695 700
Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val 705
710 715 720 Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu
Pro Arg 725 730 735 Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly
Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Gly Gly Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro 770 775 780 Cys Pro Ala Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 785 790 795 800 Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 805 810 815 Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 820 825
830 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
835 840 845 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val 850 855 860 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser 865 870 875 880 Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys 885 890 895 Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp 900 905 910 Glu Leu Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 915 920 925 Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 930 935 940 Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 945 950
955 960 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly 965 970 975 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr 980 985 990 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
995 1000 <210> SEQ ID NO 108 <211> LENGTH: 2997
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-062 <400> SEQUENCE: 108
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
ggtggcggtg gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg
gggtggatca ggcggtggag gttccggtgg cgggggatca 660 gacaaaactc
acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc 720
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
780 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
1140 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gttggactcc 1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca
agagcaggtg gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa
aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg
gcgggggatc cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440
ggttcaggtg gtggaggatc cattgtgggg ggcaaggtgt gccccaaagg ggagtgtcca
1500 tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct
gatcaacacc 1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca
agaactggag gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag
cacgacgggg atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag
cacgtacgtc ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc
accagcccgt ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800
cggacgttct ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc
1860 cagctgctgg accgtggcgc cacggccctg gagctcatgg tcctcaacgt
gccccggctg 1920 atgacccagg actgcctgca gcagtcacgg aaggtgggag
actccccaaa tatcacggag 1980 tacatgttct gtgccggcta ctcggatggc
agcaaggact cctgcaaggg ggacagtgga 2040 ggcccacatg ccacccacta
ccggggcacg tggtacctga cgggcatcgt cagctggggc 2100 cagggctgcg
caaccgtggg ccactttggg gtgtacacca gggtctccca gtacatcgag 2160
tggctgcaaa agctcatgcg ctcagagcca cgcccaggag tcctcctgcg agccccattt
2220 cccggtggcg gtggctccgg cggaggtggg tccggtggcg gcggatcagg
tgggggtgga 2280 tcaggcggtg gaggttccgg tggcggggga tcagacaaaa
ctcacacatg cccaccgtgc 2340 ccagcacctg aactcctggg aggaccgtca
gtcttcctct tccccccaaa acccaaggac 2400 accctcatga tctcccggac
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 2460 gaccctgagg
tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 2520
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg
2580 caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa
agccctccca 2640 gcccccatcg agaaaaccat ctccaaagcc aaagggcagc
cccgagaacc acaggtgtac 2700 accctgcccc catcccggga tgagctgacc
aagaaccagg tcagcctgac ctgcctggtc 2760 aaaggcttct atcccagcga
catcgccgtg gagtgggaga gcaatgggca gccggagaac 2820 aactacaaga
ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag 2880
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat
2940 gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga
2997 <210> SEQ ID NO 109 <211> LENGTH: 998 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-062 amino acid sequence <400> SEQUENCE: 109 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Gly Gly 180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Gly Gly Gly Gly
Ser Ile Val Gly Gly Lys Val Cys Pro Lys 485 490 495 Gly Glu Cys Pro
Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly
Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525
Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530
535 540 Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg
Val 545 550 555 560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly
Thr Thr Asn His 565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro
Val Val Leu Thr Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu
Arg Thr Phe Ser Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser
Leu Val Ser Gly Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr
Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met
Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650
655 Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys
660 665 670 Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His
Tyr Arg 675 680 685 Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly
Gln Gly Cys Ala 690 695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg
Val Ser Gln Tyr Ile Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg
Ser Glu Pro Arg Pro Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly
Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775
780 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
785 790 795 800 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp 805 810 815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly 820 825 830 Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900
905 910 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile 915 920 925 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr 930 935 940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys 945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro
Gly Lys 995
<210> SEQ ID NO 110 <211> LENGTH: 2997 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-090 <400> SEQUENCE: 110 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatca 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggcgg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcagccc
tgcggccccg gattgtgggg ggcaaggtgt gccccaaagg ggagtgtcca 1500
tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct gatcaacacc
1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca agaactggag
gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag cacgacgggg
atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag cacgtacgtc
ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc accagcccgt
ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800 cggacgttct
ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc 1860
cagctgctgg accgtggcgc cacggccctg gagctcatgg tcctcaacgt gccccggctg
1920 atgacccagg actgcctgca gcagtcacgg aaggtgggag actccccaaa
tatcacggag 1980 tacatgttct gtgccggcta ctcggatggc agcaaggact
cctgcaaggg ggacagtgga 2040 ggcccacatg ccacccacta ccggggcacg
tggtacctga cgggcatcgt cagctggggc 2100 cagggctgcg caaccgtggg
ccactttggg gtgtacacca gggtctccca gtacatcgag 2160 tggctgcaaa
agctcatgcg ctcagagcca cgcccaggag tcctcctgcg agccccattt 2220
cccggtggcg gtggctccgg cggaggtggg tccggtggcg gcggatcagg tgggggtgga
2280 tcaggcggtg gaggttccgg tggcggggga tcagacaaaa ctcacacatg
cccaccgtgc 2340 ccagcacctg aactcctggg aggaccgtca gtcttcctct
tccccccaaa acccaaggac 2400 accctcatga tctcccggac ccctgaggtc
acatgcgtgg tggtggacgt gagccacgaa 2460 gaccctgagg tcaagttcaa
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 2520 aagccgcggg
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 2580
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca
2640 gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc
acaggtgtac 2700 accctgcccc catcccggga tgagctgacc aagaaccagg
tcagcctgac ctgcctggtc 2760 aaaggcttct atcccagcga catcgccgtg
gagtgggaga gcaatgggca gccggagaac 2820 aactacaaga ccacgcctcc
cgtgttggac tccgacggct ccttcttcct ctacagcaag 2880 ctcaccgtgg
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2940
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga 2997
<210> SEQ ID NO 111 <211> LENGTH: 998 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-090 amino
acid sequence <400> SEQUENCE: 111 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 435
440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly
Gly Lys Val Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr Leu Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe Asp Lys
Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540 Glu His
Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545 550 555
560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr
Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val Ser Gly
Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu Glu Leu
Met Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln Asp Cys
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650 655 Asn Ile Thr
Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 660 665 670 Asp
Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg 675 680
685
Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala 690
695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile
Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro
Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775 780 Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 785 790 795 800 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 805 810
815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
820 825 830 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900 905 910 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 915 920 925 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 930 935
940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro Gly Lys 995
<210> SEQ ID NO 112 <211> LENGTH: 2982 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-100 <400> SEQUENCE: 112 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga ggtggcggtg
gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg gggtggatca
ggcggtggag gttccggtgg cgggggatcc 660 gacaaaactc acacatgccc
accgtgccca gctccggaac tcctgggagg accgtcagtc 720 ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080 aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc
1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca agagcaggtg
gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa aggtggcggc
ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg gcgggggatc
cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440 ggttcagccc
tgcggccccg gattgtgggg ggcaaggtgt gccccaaagg ggagtgtcca 1500
tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct gatcaacacc
1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca agaactggag
gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag cacgacgggg
atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag cacgtacgtc
ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc accagcccgt
ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800 cggacgttct
ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc 1860
cagctgctgg accgtggcgc cacggccctg gagctcatgg tcctcaacgt gccccggctg
1920 atgacccagg actgcgaggc cagctacccc ggcaagatca cggagtacat
gttctgtgcc 1980 ggctactcgg atggcagcaa ggactcctgc aagggggaca
gtggaggccc acatgccacc 2040 cactaccggg gcacgtggta cctgacgggc
atcgtcagct ggggccaggg ctgcgcaacc 2100 gtgggccact ttggggtgta
caccagggtc tcccagtaca tcgagtggct gcaaaagctc 2160 atgcgctcag
agccacgccc aggagtcctc ctgcgagccc catttcccgg tggcggtggc 2220
tccggcggag gtgggtccgg tggcggcgga tcaggtgggg gtggatcagg cggtggaggt
2280 tccggtggcg ggggatcaga caaaactcac acatgcccac cgtgcccagc
acctgaactc 2340 ctgggaggac cgtcagtctt cctcttcccc ccaaaaccca
aggacaccct catgatctcc 2400 cggacccctg aggtcacatg cgtggtggtg
gacgtgagcc acgaagaccc tgaggtcaag 2460 ttcaactggt acgtggacgg
cgtggaggtg cataatgcca agacaaagcc gcgggaggag 2520 cagtacaaca
gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 2580
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa
2640 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct
gcccccatcc 2700 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc
tggtcaaagg cttctatccc 2760 agcgacatcg ccgtggagtg ggagagcaat
gggcagccgg agaacaacta caagaccacg 2820 cctcccgtgt tggactccga
cggctccttc ttcctctaca gcaagctcac cgtggacaag 2880 agcaggtggc
agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 2940
cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 2982 <210> SEQ
ID NO 113 <211> LENGTH: 993 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-100 amino acid
sequence <400> SEQUENCE: 113 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310
315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu 355 360 365
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370
375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys Gly 435 440 445 Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 450 455 460 Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 465 470 475 480 Gly
Ser Ala Leu Arg Pro Arg Ile Val Gly Gly Lys Val Cys Pro Lys 485 490
495 Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu
500 505 510 Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala
Ala His 515 520 525 Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala Val Leu Gly 530 535 540 Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu Gln Ser Arg Arg Val 545 550 555 560 Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro Gly Thr Thr Asn His 565 570 575 Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val Val Leu Thr Asp His 580 585 590 Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu 595 600 605 Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp 610 615
620 Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu
625 630 635 640 Met Thr Gln Asp Cys Glu Ala Ser Tyr Pro Gly Lys Ile
Thr Glu Tyr 645 650 655 Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys
Asp Ser Cys Lys Gly 660 665 670 Asp Ser Gly Gly Pro His Ala Thr His
Tyr Arg Gly Thr Trp Tyr Leu 675 680 685 Thr Gly Ile Val Ser Trp Gly
Gln Gly Cys Ala Thr Val Gly His Phe 690 695 700 Gly Val Tyr Thr Arg
Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu 705 710 715 720 Met Arg
Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 725 730 735
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 740
745 750 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
Lys 755 760 765 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro 770 775 780 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser 785 790 795 800 Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp Val Ser His Glu Asp 805 810 815 Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn 820 825 830 Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 835 840 845 Val Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 850 855 860
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 865
870 875 880 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
Tyr Thr 885 890 895 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr 900 905 910 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu 915 920 925 Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu 930 935 940 Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 945 950 955 960 Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 965 970 975 Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 980 985
990 Lys <210> SEQ ID NO 114 <211> LENGTH: 2997
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-115 <400> SEQUENCE: 114
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
ggtggcggtg gctccggcgg aggtgggtcc 600 ggtggcggcg gatcaggtgg
gggtggatca ggcggtggag gttccggtgg cgggggatca 660 gacaaaactc
acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc 720
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
780 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 900 cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1080
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
1140 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gttggactcc 1200 gacggctcct tcttcctcta cagcaagctc accgtcgaca
agagcaggtg gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 1320 ctctccctgt ctccgggtaa
aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 1380 ggttccggtg
gcgggggatc cggcggtgga ggttccggtg ggggtggatc aggaggaggt 1440
ggttcagccc tgcggccccg gattgtgggg ggcaaggact gccccaaagg ggagtgtcca
1500 tggcaggtcc tgttgttggt gaatggagct cagttgtgtg gggggaccct
gatcaacacc 1560 atctgggtgg tctccgcggc ccactgtttc gacaaaatca
agaactggag gaacctgatc 1620 gcggtgctgg gcgagcacga cctcagcgag
cacgacgggg atgagcagag ccggcgggtg 1680 gcgcaggtca tcatccccag
cacgtacgtc ccgggcacca ccaaccacga catcgcgctg 1740 ctccgcctgc
accagcccgt ggtcctcact gaccatgtgg tgcccctctg cctgcccgaa 1800
cggacgttct ctgagaggac gctggccttc gtgcgcttct cattggtcag cggctggggc
1860 cagctgctgg accgtggcgc cacggccctg gtactccaag tcctcaacgt
gccccggctg 1920 atgacccagg actgcctgca gcagtcacgg aaggtgggag
actccccaaa tatcacggag 1980 tacatgttct gtgccggcta ctcggatggc
agcaaggact cctgcaaggg ggacagtgga 2040 ggcccacatg ccacccacta
ccggggcacg tggtacctga cgggcatcgt cagctggggc 2100 cagggctgcg
caaccgtggg ccactttggg gtgtacacca gggtctccca gtacatcgag 2160
tggctgcaaa agctcatgcg ctcagagcca cgcccaggag tcctcctgcg agccccattt
2220 cccggtggcg gtggctccgg cggaggtggg tccggtggcg gcggatcagg
tgggggtgga 2280 tcaggcggtg gaggttccgg tggcggggga tcagacaaaa
ctcacacatg cccaccgtgc 2340 ccagcacctg aactcctggg aggaccgtca
gtcttcctct tccccccaaa acccaaggac 2400 accctcatga tctcccggac
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 2460 gaccctgagg
tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 2520
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg
2580 caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa
agccctccca 2640 gcccccatcg agaaaaccat ctccaaagcc aaagggcagc
cccgagaacc acaggtgtac 2700 accctgcccc catcccggga tgagctgacc
aagaaccagg tcagcctgac ctgcctggtc 2760 aaaggcttct atcccagcga
catcgccgtg gagtgggaga gcaatgggca gccggagaac 2820 aactacaaga
ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag 2880
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat
2940 gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga
2997 <210> SEQ ID NO 115 <211> LENGTH: 998 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-115 amino acid sequence <400> SEQUENCE: 115 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu
50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe
Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro
Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr
Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu
Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly
Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg
Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp
Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170
175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly
180 185 190 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly 195 200 205 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295
300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420
425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly 450 455 460 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly 465 470 475 480 Gly Ser Ala Leu Arg Pro Arg Ile
Val Gly Gly Lys Asp Cys Pro Lys 485 490 495 Gly Glu Cys Pro Trp Gln
Val Leu Leu Leu Val Asn Gly Ala Gln Leu 500 505 510 Cys Gly Gly Thr
Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His 515 520 525 Cys Phe
Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly 530 535 540
Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val 545
550 555 560 Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr
Asn His 565 570 575 Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val
Leu Thr Asp His 580 585 590 Val Val Pro Leu Cys Leu Pro Glu Arg Thr
Phe Ser Glu Arg Thr Leu 595 600 605 Ala Phe Val Arg Phe Ser Leu Val
Ser Gly Trp Gly Gln Leu Leu Asp 610 615 620 Arg Gly Ala Thr Ala Leu
Val Leu Gln Val Leu Asn Val Pro Arg Leu 625 630 635 640 Met Thr Gln
Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro 645 650 655 Asn
Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys 660 665
670 Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg
675 680 685 Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly
Cys Ala 690 695 700 Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser
Gln Tyr Ile Glu 705 710 715 720 Trp Leu Gln Lys Leu Met Arg Ser Glu
Pro Arg Pro Gly Val Leu Leu 725 730 735 Arg Ala Pro Phe Pro Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly 740 745 750 Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 755 760 765 Gly Gly Ser
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 770 775 780 Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 785 790
795 800 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp 805 810 815 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly 820 825 830 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn 835 840 845 Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp Trp 850 855 860 Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala Leu Pro 865 870 875 880 Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 885 890 895 Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 900 905 910
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 915
920 925 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr 930 935 940 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys 945 950 955 960 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys 965 970 975 Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu 980 985 990 Ser Leu Ser Pro Gly Lys
995 <210> SEQ ID NO 116 <211> LENGTH: 2859 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-118 <400> SEQUENCE: 116 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggcgcc ctgcggcccc
ggattgtggg gggcaaggtg 600 tgccccaaag gggagtgtcc atggcaggtc
ctgttgttgg tgaatggagc tcagttgtgt 660 ggggggaccc tgatcaacac
catctgggtg gtctccgcgg cccactgttt cgacaaaatc 720 aagaactgga
ggaacctgat cgcggtgctg ggcgagcacg acctcagcga gcacgacggg 780
gatgagcaga gccggcgggt ggcgcaggtc atcatcccca gcacgtacgt cccgggcacc
840 accaaccacg acatcgcgct gctccgcctg caccagcccg tggtcctcac
tgaccatgtg 900 gtgcccctct gcctgcccga acggacgttc tctgagagga
cgctggcctt cgtgcgcttc 960 tcattggtca gcggctgggg ccagctgctg
gaccgtggcg ccacggccct ggagctcatg 1020 gtcctcaacg tgccccggct
gatgacccag gactgcctgc agcagtcacg gaaggtggga 1080 gactccccaa
atatcacgga gtacatgttc tgtgccggct actcggatgg cagcaaggac 1140
tcctgcaagg gggacagtgg aggcccacat gccacccact accggggcac gtggtacctg
1200 acgggcatcg tcagctgggg ccagggctgc gcaaccgtgg gccactttgg
ggtgtacacc 1260 agggtctccc agtacatcga gtggctgcaa aagctcatgc
gctcagagcc acgcccagga 1320 gtcctcctgc gagccccatt tcccggtggc
ggtggctccg gcggaggtgg gtccggtggc 1380 ggcggatcag gtgggggtgg
atcaggcggt ggaggttccg gtggcggggg atccgacaaa 1440 actcacacat
gcccaccgtg cccagctccg gaactcctgg gcggaccgtc agtcttcctc 1500
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg
1560 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt
ggacggcgtg 1620 gaggtgcata atgccaagac aaagccgcgg gaggagcagt
acaacagcac gtaccgtgtg 1680 gtcagcgtcc tcaccgtcct gcaccaggac
tggctgaatg gcaaggagta caagtgcaag 1740 gtctccaaca aagccctccc
agcccccatc gagaaaacca tctccaaagc caaagggcag 1800 ccccgagaac
cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1860
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag
1920 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgttgga
ctccgacggc 1980 tccttcttcc tctacagcaa gctcaccgtg gacaagagca
ggtggcagca ggggaacgtc 2040 ttctcatgct ccgtgatgca tgaggctctg
cacaaccact acacgcagaa gagcctctcc 2100 ctgtctccgg gtaaaggtgg
cggcggatca ggtgggggtg gatcaggcgg tggaggttcc 2160 ggtggcgggg
gatcagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 2220
ggaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg
2280 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga
ggtcaagttc 2340 aactggtacg tggacggcgt ggaggtgcat aatgccaaga
caaagccgcg ggaggagcag 2400 tacaacagca cgtaccgtgt ggtcagcgtc
ctcaccgtcc tgcaccagga ctggctgaat 2460 ggcaaggagt acaagtgcaa
ggtctccaac aaagccctcc cagcccccat cgagaaaacc 2520 atctccaaag
ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc 2580
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc
2640 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa
gaccacgcct 2700 cccgtgttgg actccgacgg ctccttcttc ctctacagca
agctcaccgt ggacaagagc 2760 aggtggcagc aggggaacgt cttctcatgc
tccgtgatgc atgaggctct gcacaaccac 2820 tacacgcaga agagcctctc
cctgtctccg ggtaaatga 2859 <210> SEQ ID NO 117 <211>
LENGTH: 952 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FVII-118 amino acid sequence <400>
SEQUENCE: 117 Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu
Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu
Glu Ala His Gly Val 20 25 30 Leu His Arg Arg Arg Arg Ala Asn Ala
Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser Leu Glu Arg Glu Cys
Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60 Ala Arg Glu Ile Phe
Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser
Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 85 90 95 Gly
Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 100 105
110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile
115 120 125 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp
His Thr 130 135 140 Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr
Ser Leu Leu Ala 145 150 155 160 Asp Gly Val Ser Cys Thr Pro Thr Val
Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro Ile Leu Glu Lys Arg Asn
Ala Ser Lys Pro Gln Gly Ala Leu Arg 180 185 190 Pro Arg Ile Val Gly
Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp 195 200 205 Gln Val Leu
Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu 210 215 220 Ile
Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile 225 230
235 240 Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu
Ser 245 250 255 Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln
Val Ile Ile 260 265 270 Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His
Asp Ile Ala Leu Leu 275 280 285 Arg Leu His Gln Pro Val Val Leu Thr
Asp His Val Val Pro Leu Cys 290 295 300 Leu Pro Glu Arg Thr Phe Ser
Glu Arg Thr Leu Ala Phe Val Arg Phe 305 310 315 320 Ser Leu Val Ser
Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala 325 330 335 Leu Glu
Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys 340 345 350
Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr 355
360 365 Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys
Gly 370 375 380 Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr
Trp Tyr Leu 385 390 395 400 Thr Gly Ile Val Ser Trp Gly Gln Gly Cys
Ala Thr Val Gly His Phe 405 410 415 Gly Val Tyr Thr Arg Val Ser Gln
Tyr Ile Glu Trp Leu Gln Lys Leu 420 425 430 Met Arg Ser Glu Pro Arg
Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 435 440 445 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 465 470 475
480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600
605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 Lys Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720
Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 725
730 735 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro 740 745 750 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val 755 760 765 Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val 770 775 780 Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln 785 790 795 800 Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln 805 810 815 Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 820 825 830 Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 835 840 845
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 850
855 860 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser 865 870 875 880 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr 885 890 895 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr 900 905 910 Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 915 920 925 Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 930 935 940 Ser Leu Ser Leu
Ser Pro Gly Lys 945 950 <210> SEQ ID NO 118 <211>
LENGTH: 2874 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVII-119 <400>
SEQUENCE: 118 atggtctccc aggccctcag gctcctctgc cttctgcttg
ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga ggaagcccac
ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg aggagctgcg
gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180 tccttcgagg
aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt 240
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggcgga ggaggtggtt
cagccctgcg gccccggatt 600 gtggggggca aggtgtgccc caaaggggag
tgtccatggc aggtcctgtt gttggtgaat 660 ggagctcagt tgtgtggggg
gaccctgatc aacaccatct gggtggtctc cgcggcccac 720 tgtttcgaca
aaatcaagaa ctggaggaac ctgatcgcgg tgctgggcga gcacgacctc 780
agcgagcacg acggggatga gcagagccgg cgggtggcgc aggtcatcat ccccagcacg
840 tacgtcccgg gcaccaccaa ccacgacatc gcgctgctcc gcctgcacca
gcccgtggtc 900 ctcactgacc atgtggtgcc cctctgcctg cccgaacgga
cgttctctga gaggacgctg 960 gccttcgtgc gcttctcatt ggtcagcggc
tggggccagc tgctggaccg tggcgccacg 1020 gccctggagc tcatggtcct
caacgtgccc cggctgatga cccaggactg cctgcagcag 1080 tcacggaagg
tgggagactc cccaaatatc acggagtaca tgttctgtgc cggctactcg 1140
gatggcagca aggactcctg caagggggac agtggaggcc cacatgccac ccactaccgg
1200 ggcacgtggt acctgacggg catcgtcagc tggggccagg gctgcgcaac
cgtgggccac 1260 tttggggtgt acaccagggt ctcccagtac atcgagtggc
tgcaaaagct catgcgctca 1320 gagccacgcc caggagtcct cctgcgagcc
ccatttcccg gtggcggtgg ctccggcgga 1380 ggtgggtccg gtggcggcgg
atcaggtggg ggtggatcag gcggtggagg ttccggtggc 1440 gggggatccg
acaaaactca cacatgccca ccgtgcccag ctccggaact cctgggcgga 1500
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct
1560 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa
gttcaactgg 1620 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc
cgcgggagga gcagtacaac 1680 agcacgtacc gtgtggtcag cgtcctcacc
gtcctgcacc aggactggct gaatggcaag 1740 gagtacaagt gcaaggtctc
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1800 aaagccaaag
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1860
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc
1920 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac
gcctcccgtg 1980 ttggactccg acggctcctt cttcctctac agcaagctca
ccgtggacaa gagcaggtgg 2040 cagcagggga acgtcttctc atgctccgtg
atgcatgagg ctctgcacaa ccactacacg 2100 cagaagagcc tctccctgtc
tccgggtaaa ggtggcggcg gatcaggtgg gggtggatca 2160 ggcggtggag
gttccggtgg cgggggatca gacaaaactc acacatgccc accgtgccca 2220
gcacctgaac tcctgggagg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
2280 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 2340 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 2400 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 2460 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 2520 cccatcgaga
aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 2580
ctgcccccat cccgcgatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
2640 ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 2700 tacaagacca cgcctcccgt gttggactcc gacggctcct
tcttcctcta cagcaagctc 2760 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 2820 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 2874 <210> SEQ ID NO
119 <211> LENGTH: 957 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-119 amino acid
sequence <400> SEQUENCE: 119 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Gly Gly Gly 180 185
190 Gly Ser Ala Leu Arg Pro Arg Ile Val Gly Gly Lys Val Cys Pro Lys
195 200 205 Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala
Gln Leu 210 215 220 Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val
Ser Ala Ala His 225 230 235 240 Cys Phe Asp Lys Ile Lys Asn Trp Arg
Asn Leu Ile Ala Val Leu Gly 245 250 255 Glu His Asp Leu Ser Glu His
Asp Gly Asp Glu Gln Ser Arg Arg Val 260 265 270 Ala Gln Val Ile Ile
Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His 275 280 285 Asp Ile Ala
Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His 290 295 300 Val
Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu 305 310
315 320 Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu
Asp 325 330 335 Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val
Pro Arg Leu 340 345 350 Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys
Val Gly Asp Ser Pro 355 360 365 Asn Ile Thr Glu Tyr Met Phe Cys Ala
Gly Tyr Ser Asp Gly Ser Lys 370 375 380 Asp Ser Cys Lys Gly Asp Ser
Gly Gly Pro His Ala Thr His Tyr Arg 385 390 395 400 Gly Thr Trp Tyr
Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala 405 410 415 Thr Val
Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu 420 425 430
Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu 435
440 445 Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly 450 455 460 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly 465 470 475 480 Gly Gly Ser Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu 485 490 495 Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp 500 505 510 Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val Asp 515 520 525 Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 530 535 540 Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 545 550 555
560 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
565 570 575 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro 580 585 590 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg Glu 595 600 605 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn 610 615 620 Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile 625 630 635 640 Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 645 650 655 Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 660 665 670 Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 675 680
685 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
690 695 700 Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser 705 710 715 720 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
Lys Thr His Thr Cys 725 730 735 Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu 740 745 750 Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu 755 760 765 Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys 770 775 780 Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 785 790 795 800
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 805
810 815 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 820 825 830 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 835 840 845
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 850
855 860 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 865 870 875 880 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln 885 890 895 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly 900 905 910 Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln 915 920 925 Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn 930 935 940 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 945 950 955 <210> SEQ ID
NO 120 <211> LENGTH: 2844 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-127
<400> SEQUENCE: 120 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcagtcttcg taacccagga
ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac 120 gcgttcctgg
aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc 180
tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt
240 tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg
ctcctgcaag 300 gaccagctcc agtcctatat ctgcttctgc ctccctgcct
tcgagggccg gaactgtgag 360 acgcacaagg atgaccagct gatctgtgtg
aacgagaacg gcggctgtga gcagtactgc 420 agtgaccaca cgggcaccaa
gcgctcctgt cggtgccacg aggggtactc tctgctggca 480 gacggggtgt
cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa 540
aaaagaaatg ccagcaaacc ccaaggcgcc ctgcggcccc ggattgtggg gggcaaggtg
600 tgccccaaag gggagtgtcc atggcaggtc ctgttgttgg tgaatggagc
tcagttgtgt 660 ggggggaccc tgatcaacac catctgggtg gtctccgcgg
cccactgttt cgacaaaatc 720 aagaactgga ggaacctgat cgcggtgctg
ggcgagcacg acctcagcga gcacgacggg 780 gatgagcaga gccggcgggt
ggcgcaggtc atcatcccca gcacgtacgt cccgggcacc 840 accaaccacg
acatcgcgct gctccgcctg caccagcccg tggtcctcac tgaccatgtg 900
gtgcccctct gcctgcccga acggacgttc tctgagagga cgctggcctt cgtgcgcttc
960 tcattggtca gcggctgggg ccagctgctg gaccgtggcg ccacggccct
ggagctcatg 1020 gtcctcaacg tgccccggct gatgacccag gactgcgagg
ccagctaccc cggcaagatc 1080 acggagtaca tgttctgtgc cggctactcg
gatggcagca aggactcctg caagggggac 1140 agtggaggcc cacatgccac
ccactaccgg ggcacgtggt acctgacggg catcgtcagc 1200 tggggccagg
gctgcgcaac cgtgggccac tttggggtgt acaccagggt ctcccagtac 1260
atcgagtggc tgcaaaagct catgcgctca gagccacgcc caggagtcct cctgcgagcc
1320 ccatttcccg gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg
atcaggtggg 1380 ggtggatcag gcggtggagg ttccggtggc gggggatcag
acaaaactca cacatgccca 1440 ccgtgcccag ctccggaact cctgggcgga
ccgtcagtct tcctcttccc cccaaaaccc 1500 aaggacaccc tcatgatctc
ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 1560 cacgaagacc
ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1620
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
1680 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 1740 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag
ggcagccccg agaaccacag 1800 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 1860 ctggtcaaag gcttctatcc
cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1920 gagaacaact
acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac 1980
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
2040 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaaa 2100 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag
gttccggtgg cgggggatca 2160 gacaaaactc acacatgccc accgtgccca
gcacctgaac tcctgggagg accgtcagtc 2220 ttcctcttcc ccccaaaacc
caaggacacc ctcatgatct cccggacccc tgaggtcaca 2280 tgcgtggtgg
tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 2340
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac
2400 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa
ggagtacaag 2460 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga
aaaccatctc caaagccaaa 2520 gggcagcccc gagaaccaca ggtgtacacc
ctgcccccat cccgcgatga gctgaccaag 2580 aaccaggtca gcctgacctg
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 2640 tgggagagca
atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc 2700
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg
2760 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac
gcagaagagc 2820 ctctccctgt ctccgggtaa atga 2844 <210> SEQ ID
NO 121 <211> LENGTH: 947 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-127 amino acid
sequence <400> SEQUENCE: 121 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Ala Leu Arg 180 185
190 Pro Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp
195 200 205 Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly
Thr Leu 210 215 220 Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys
Phe Asp Lys Ile 225 230 235 240 Lys Asn Trp Arg Asn Leu Ile Ala Val
Leu Gly Glu His Asp Leu Ser 245 250 255 Glu His Asp Gly Asp Glu Gln
Ser Arg Arg Val Ala Gln Val Ile Ile 260 265 270 Pro Ser Thr Tyr Val
Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu 275 280 285 Arg Leu His
Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys 290 295 300 Leu
Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe 305 310
315 320 Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr
Ala 325 330 335 Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr
Gln Asp Cys 340 345 350 Glu Ala Ser Tyr Pro Gly Lys Ile Thr Glu Tyr
Met Phe Cys Ala Gly 355 360 365 Tyr Ser Asp Gly Ser Lys Asp Ser Cys
Lys Gly Asp Ser Gly Gly Pro 370 375 380 His Ala Thr His Tyr Arg Gly
Thr Trp Tyr Leu Thr Gly Ile Val Ser 385 390 395 400 Trp Gly Gln Gly
Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg 405 410 415 Val Ser
Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro 420 425 430
Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser 435
440 445 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly 450 455 460 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His
Thr Cys Pro 465 470 475 480 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe 485 490 495 Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val 500 505 510 Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe 515 520 525 Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 530 535 540 Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 545 550 555
560 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
565 570 575 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys Ala 580 585 590
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 595
600 605 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly 610 615 620 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro 625 630 635 640 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser 645 650 655 Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln 660 665 670 Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His 675 680 685 Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 690 695 700 Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715
720 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
725 730 735 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met 740 745 750 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His 755 760 765 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val 770 775 780 His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr 785 790 795 800 Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 805 810 815 Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 820 825 830 Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 835 840
845 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
850 855 860 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu 865 870 875 880 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro 885 890 895 Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val 900 905 910 Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met 915 920 925 His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 930 935 940 Pro Gly Lys
945 <210> SEQ ID NO 122 <211> LENGTH: 2169 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVII-125 <400> SEQUENCE: 122 atggtctccc
aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct 60
gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac
120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga
ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag gacgcggaga
ggacgaagct gttctggatt 240 tcttacagtg atggggacca gtgtgcctca
agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc agtcctatat
ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360 acgcacaagg
atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc 420
agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca
480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc
tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga attgtggggg
gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct gttgttggtg
aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca tctgggtggt
ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720 aacctgatcg
cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc 780
cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac
840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt
gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg ctggccttcg
tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga ccgtggcgcc
acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga tgacccagga
ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080 atcacggagt
acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg 1140
gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc
1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag
ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac
gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg tggctccggc
ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat caggcggtgg
aggttccggt ggcgggggat ccgacatcgt gatgacccag 1440 gccgccccca
gcgtgcccgt gacccccggc gagagcgtga gcatcagctg ccggagcagc 1500
cggagcctgc tgcacagcaa cggcaacacc tacctgtgct ggttcctgca gcggcccggc
1560 cagagccccc agctgctgat ctaccggatg agcaacctgg ccagcggcgt
gcccgaccgg 1620 ttcagcggca gcggcagcgg caccgccttc accctgcgga
tcagccgggt ggaggccgag 1680 gacgtgggcg tgtactactg catgcagcac
ctggagtacc ccttcacctt cggcagcggc 1740 accaagctgg agatcaagcg
gggcggcggc ggcagcggcg gcggcggcag cggcggcggc 1800 ggcagccagg
tgcagctgca gcagagcggc gccgagctgg tgcggcccgg caccagcgtg 1860
aagatcagct gcaaggccag cggctacacc ttcaccaact actggctggg ctgggtgaag
1920 cagcggcccg gccacggcct ggagtggatc ggcgacatct accccggcgg
cggctacaac 1980 aagtacaacg agaacttcaa gggcaaggcc accctgaccg
ccgacaccag cagcagcacc 2040 gcctacatgc agctgagcag cctgaccagc
gaggacagcg ccgtgtactt ctgcgcccgg 2100 gagtacggca actacgacta
cgccatggac agctggggcc agggcaccag cgtgaccgtg 2160 agcagctga 2169
<210> SEQ ID NO 123 <211> LENGTH: 722 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-125 amino
acid sequence <400> SEQUENCE: 123 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu
Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser
Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala Thr His Tyr Arg
Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400 Ser Trp Gly Gln
Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405 410 415 Arg Val
Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 420 425 430
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435
440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 450 455 460
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 465
470 475 480 Ala Ala Pro Ser Val Pro Val Thr Pro Gly Glu Ser Val Ser
Ile Ser 485 490 495 Cys Arg Ser Ser Arg Ser Leu Leu His Ser Asn Gly
Asn Thr Tyr Leu 500 505 510 Cys Trp Phe Leu Gln Arg Pro Gly Gln Ser
Pro Gln Leu Leu Ile Tyr 515 520 525 Arg Met Ser Asn Leu Ala Ser Gly
Val Pro Asp Arg Phe Ser Gly Ser 530 535 540 Gly Ser Gly Thr Ala Phe
Thr Leu Arg Ile Ser Arg Val Glu Ala Glu 545 550 555 560 Asp Val Gly
Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr 565 570 575 Phe
Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser 580 585
590 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
595 600 605 Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile
Ser Cys 610 615 620 Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Trp Leu
Gly Trp Val Lys 625 630 635 640 Gln Arg Pro Gly His Gly Leu Glu Trp
Ile Gly Asp Ile Tyr Pro Gly 645 650 655 Gly Gly Tyr Asn Lys Tyr Asn
Glu Asn Phe Lys Gly Lys Ala Thr Leu 660 665 670 Thr Ala Asp Thr Ser
Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 675 680 685 Thr Ser Glu
Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Tyr Gly Asn 690 695 700 Tyr
Asp Tyr Ala Met Asp Ser Trp Gly Gln Gly Thr Ser Val Thr Val 705 710
715 720 Ser Ser <210> SEQ ID NO 124 <211> LENGTH: 3750
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-067 <400> SEQUENCE: 124
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctgggc ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtgga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaaggtggcg
gcggatcagg tgggggtgga tcaggcggtg gaggttccgg tggcggggga 2160
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg aggaccgtca
2220 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac
ccctgaggtc 2280 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg
tcaagttcaa ctggtacgtg 2340 gacggcgtgg aggtgcataa tgccaagaca
aagccgcggg aggagcagta caacagcacg 2400 taccgtgtgg tcagcgtcct
caccgtcctg caccaggact ggctgaatgg caaggagtac 2460 aagtgcaagg
tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 2520
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccgcga tgagctgacc
2580 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga
catcgccgtg 2640 gagtgggaga gcaatgggca gccggagaac aactacaaga
ccacgcctcc cgtgttggac 2700 tccgacggct ccttcttcct ctacagcaag
ctcaccgtcg acaagagcag gtggcagcag 2760 gggaacgtct tctcatgctc
cgtgatgcat gaggctctgc acaaccacta cacgcagaag 2820 agcctctccc
tgtctccggg taaaggtggc ggtggctccg gcggaggtgg gtccggtggc 2880
ggcggatcag gtgggggtgg atcaggcggt ggaggttccg gtggcggggg atcagcgcag
2940 gtgcagctgc aggagtctgg gggaggcttg gtacagcctg gggggtccct
gagactctcc 3000 tgtgcagcct ctggattcat gtttagcagg tatgccatga
gctgggtccg ccaggctcca 3060 gggaaggggc cagagtgggt ctcaggtatt
agtggtagtg gtggtagtac atactacgca 3120 gactccgtga agggccggtt
caccgtctcc agagacaatt ccaagaacac gctgtatctg 3180 caaatgaaca
gcctgagagc cgaggacacg gctgtatatt actgcgcccg gggcgccacc 3240
tacaccagcc ggagcgacgt gcccgaccag accagcttcg actactgggg ccagggaacc
3300 ctggtcaccg tctcctcagg gagtgcatcc gccccaaagc ttgaagaagg
tgaattttca 3360 gaagcacgcg tatctgaact gactcaggac cctgctgtgt
ctgtggcctt gggacagaca 3420 gtcaggatca catgccaagg agacagcctc
agaaactttt atgcaagctg gtaccagcag 3480 aagccaggac aggcccctac
tcttgtcatc tatggtttaa gtaaaaggcc ctcagggatc 3540 ccagaccgat
tctctgcctc cagctcagga aacacagctt ccttgaccat cactggggct 3600
caggcggaag atgaggctga ctattactgc ctgctgtact acggcggcgg ccagcagggc
3660 gtgttcggcg gcggcaccaa gctgaccgtc ctacgtcagc ccaaggctgc
cccctcggtc 3720 actctgttcc cgccctcttc tgcggcctga 3750 <210>
SEQ ID NO 125 <211> LENGTH: 1249 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVII-067 amino
acid sequence <400> SEQUENCE: 125 Met Val Ser Gln Ala Leu Arg
Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala
Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg
Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly
Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55
60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln
275 280 285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro
Glu Arg 290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe
Ser Leu Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly
Ala Thr Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg Leu
Met Thr Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp
Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser
Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro
His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390
395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr
Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met
Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe
Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Asp Lys Thr His Thr Cys 465 470 475 480 Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 500 505 510
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 515
520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 545 550 555 560 Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 565 570 575 Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 610 615 620 Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 625 630 635
640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys Gly Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 705 710 715 720 Ser Asp Lys Thr His
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 725 730 735 Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 740 745 750 Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 755 760
765 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
770 775 780 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
Ser Thr 785 790 795 800 Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln Asp Trp Leu Asn 805 810 815 Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala Leu Pro Ala Pro 820 825 830 Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro Arg Glu Pro Gln 835 840 845 Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 850 855 860 Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 865 870 875 880
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 885
890 895 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr 900 905 910 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val 915 920 925 Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu 930 935 940 Ser Pro Gly Lys Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 945 950 955 960 Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 965 970 975 Gly Ser Ala Gln
Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 980 985 990 Pro Gly
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe 995 1000
1005 Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
1010 1015 1020 Pro Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Gly Ser
Thr Tyr 1025 1030 1035 Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val
Ser Arg Asp Asn 1040 1045 1050 Ser Lys Asn Thr Leu Tyr Leu Gln Met
Asn Ser Leu Arg Ala Glu 1055 1060 1065 Asp Thr Ala Val Tyr Tyr Cys
Ala Arg Gly Ala Thr Tyr Thr Ser 1070 1075 1080 Arg Ser Asp Val Pro
Asp Gln Thr Ser Phe Asp Tyr Trp Gly Gln 1085 1090 1095 Gly Thr Leu
Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys 1100 1105 1110 Leu
Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Glu Leu Thr 1115 1120
1125 Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile
1130 1135 1140 Thr Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser
Trp Tyr 1145 1150 1155 Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val
Ile Tyr Gly Leu 1160 1165 1170 Ser Lys Arg Pro Ser Gly Ile Pro Asp
Arg Phe Ser Ala Ser Ser 1175 1180 1185 Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala Gln Ala Glu 1190 1195 1200 Asp Glu Ala Asp Tyr
Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly Gln 1205 1210 1215 Gln Gly Val
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Gln 1220 1225 1230 Pro
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala 1235 1240
1245 Ala <210> SEQ ID NO 126 <211> LENGTH: 2244
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-094 <400> SEQUENCE: 126
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccgatatcgg
tggcggtggc tccggcggag gtgggtccgg tggcggcgga 1380 tcaggtgggg
gtggatcagg cggtggaggt tccggtggcg ggggatcagc gcaggtgcag 1440
ctgcaggagt ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca
1500 gcctctggat tcatgtttag caggtatgcc atgagctggg tccgccaggc
tccagggaag 1560 gggccagagt gggtctcagg tattagtggt agtggtggta
gtacatacta cgcagactcc 1620
gtgaagggcc ggttcaccgt ctccagagac aattccaaga acacgctgta tctgcaaatg
1680 aacagcctga gagccgagga cacggctgta tattactgcg cccggggcgc
cacctacacc 1740 agccggagcg acgtgcccga ccagaccagc ttcgactact
ggggccaggg aaccctggtc 1800 accgtctcct cagggagtgc atccgcccca
aagcttgaag aaggtgaatt ttcagaagca 1860 cgcgtatctg aactgactca
ggaccctgct gtgtctgtgg ccttgggaca gacagtcagg 1920 atcacatgcc
aaggagacag cctcagaaac ttttatgcaa gctggtacca gcagaagcca 1980
ggacaggccc ctactcttgt catctatggt ttaagtaaaa ggccctcagg gatcccagac
2040 cgattctctg cctccagctc aggaaacaca gcttccttga ccatcactgg
ggctcaggcg 2100 gaagatgagg ctgactatta ctgcctgctg tactacggcg
gcggccagca gggcgtgttc 2160 ggcggcggca ccaagctgac cgtcctacgt
cagcccaagg ctgccccctc ggtcactctg 2220 ttcccgccct cttctgcggc ctga
2244 <210> SEQ ID NO 127 <211> LENGTH: 747 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FVII-094 amino acid sequence <400> SEQUENCE: 127 Met Val Ser
Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly
Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25
30 Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
35 40 45 Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe
Glu Glu 50 55 60 Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys
Leu Phe Trp Ile 65 70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser
Ser Pro Cys Gln Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln
Ser Tyr Ile Cys Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn
Cys Glu Thr His Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu
Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr
Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155
160 Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
165 170 175 Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg
Ile Val 180 185 190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp
Gln Val Leu Leu 195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly
Thr Leu Ile Asn Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys
Phe Asp Lys Ile Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val
Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln
Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val
Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280
285 Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg
290 295 300 Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu
Val Ser 305 310 315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr
Ala Leu Glu Leu Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr
Gln Asp Cys Leu Gln Gln Ser 340 345 350 Arg Lys Val Gly Asp Ser Pro
Asn Ile Thr Glu Tyr Met Phe Cys Ala 355 360 365 Gly Tyr Ser Asp Gly
Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 370 375 380 Pro His Ala
Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 385 390 395 400
Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 405
410 415 Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser
Glu 420 425 430 Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Asp
Ile Gly Gly 435 440 445 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly 450 455 460 Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Gln Val Gln 465 470 475 480 Leu Gln Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 485 490 495 Leu Ser Cys Ala
Ala Ser Gly Phe Met Phe Ser Arg Tyr Ala Met Ser 500 505 510 Trp Val
Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile 515 520 525
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 530
535 540 Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
Met 545 550 555 560 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys Ala Arg Gly 565 570 575 Ala Thr Tyr Thr Ser Arg Ser Asp Val Pro
Asp Gln Thr Ser Phe Asp 580 585 590 Tyr Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly Ser Ala Ser 595 600 605 Ala Pro Lys Leu Glu Glu
Gly Glu Phe Ser Glu Ala Arg Val Ser Glu 610 615 620 Leu Thr Gln Asp
Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 625 630 635 640 Ile
Thr Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser Trp Tyr 645 650
655 Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser
660 665 670 Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser
Ser Gly 675 680 685 Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala
Glu Asp Glu Ala 690 695 700 Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly
Gly Gln Gln Gly Val Phe 705 710 715 720 Gly Gly Gly Thr Lys Leu Thr
Val Leu Arg Gln Pro Lys Ala Ala Pro 725 730 735 Ser Val Thr Leu Phe
Pro Pro Ser Ser Ala Ala 740 745 <210> SEQ ID NO 128
<211> LENGTH: 3507 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FVII-028
<400> SEQUENCE: 128 atggtctccc aggccctcag gctcctctgc
cttctgcttg ggcttcaggg ctgcctggct 60 gcggaagtgc agctggtgca
gtctggagct gaggtgaata agcctggggc ctcagtgaag 120 gtctcctgca
aggcttctgg atacaccttc accggctact atatgcactg ggtgcgacag 180
gcccctggac aagggcttga gtggatggga tggatcaacc ctaacagtgg tggcacaaac
240 tatgcacaga agtttcaggg ctgggtcacc atgaccaggg acacgtccat
cagcaccgcc 300 tacatggagc tgagcaggct gagatctgac gacacggccg
tgtattactg tgcgagaggc 360 cgtgctttgt ataaccggaa cgaccggtcc
cccaactggt tcgacccctg gggccaggga 420 accctggtca ccgtctcctc
agggagtgca tccgccccaa cccttaaact tgaagaaggt 480 gaattttcag
aagcacgcgt acaggctgtg ctgactcagc cgccctcggt gtcagtggcc 540
ccaggacaga cggccaggat tacctgtggg ggaaacaaca ttggaagtaa aagtgtgcag
600 tggtaccagc agaagccagg ccaggcccct gtgctggtcg tctatgatga
tagcgaccgg 660 ccctcaggga tccctgagcg attctctggc tccaactctg
ggaacatggc caccctgacc 720 atcagcaggg tcgaagccgg ggatgaggcc
gactattact gtcaggtgtg ggatagtagt 780 agtgatcatg tggtattcgg
cggagggacc aagctgaccg tcctaggtca gcccaaggct 840 gccccctcgg
tcactctgtt cccgccgtcc gcggccgcta ggacgaagct gttctggatt 900
tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag
960 gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg
gaactgtgag 1020 acgcacaagg atgaccagct gatctgtgtg aacgagaacg
gcggctgtga gcagtactgc 1080 agtgaccaca cgggcaccaa gcgctcctgt
cggtgccacg aggggtactc tctgctggca 1140 gacggggtgt cctgcacacc
cacagttgaa tatccatgtg gaaaaatacc tattctagaa 1200 aaaagaaatg
ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg 1260
gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg ggggaccctg
1320 atcaacacca tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa
gaactggagg 1380 aacctgatcg cggtgctggg cgagcacgac ctcagcgagc
acgacgggga tgagcagagc 1440 cggcgggtgg cgcaggtcat catccccagc
acgtacgtcc cgggcaccac caaccacgac 1500 atcgcgctgc tccgcctgca
ccagcccgtg gtcctcactg accatgtggt gcccctctgc 1560 ctgcccgaac
ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc 1620
ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt cctcaacgtg
1680 ccccggctga tgacccagga ctgcctgcag cagtcacgga aggtgggaga
ctccccaaat 1740 atcacggagt acatgttctg tgccggctac tcggatggca
gcaaggactc ctgcaagggg 1800 gacagtggag gcccacatgc cacccactac
cggggcacgt ggtacctgac gggcatcgtc 1860 agctggggcc agggctgcgc
aaccgtgggc cactttgggg tgtacaccag ggtctcccag 1920 tacatcgagt
ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga 1980
gccccatttc ccggtggcgg tggctccggc ggaggtgggt ccggtggcgg cggatcaggt
2040 gggggtggat caggcggtgg aggttccggt ggcgggggat ccgacaaaac
tcacacatgc 2100 ccaccgtgcc cagctccgga actcctgggc ggaccgtcag
tcttcctctt ccccccaaaa 2160 cccaaggaca ccctcatgat ctcccggacc
cctgaggtca catgcgtggt ggtggacgtg 2220 agccacgaag accctgaggt
caagttcaac tggtacgtgg acggcgtgga ggtgcataat 2280 gccaagacaa
agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 2340
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa
2400 gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc
ccgagaacca 2460 caggtgtaca ccctgccccc atcccgggat gagctgacca
agaaccaggt cagcctgacc 2520 tgcctggtca aaggcttcta tcccagcgac
atcgccgtgg agtgggagag caatgggcag 2580 ccggagaaca actacaagac
cacgcctccc gtgttggact ccgacggctc cttcttcctc 2640 tacagcaagc
tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2700
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt
2760 aaaggtggcg gcggatcagg tgggggtgga tcaggcggtg gaggttccgg
tggcggggga 2820 tccgacaaaa ctcacacatg cccaccgtgc ccagcacctg
aactcctggg aggaccgtca 2880 gtcttcctct tccccccaaa acccaaggac
accctcatga tctcccggac ccctgaggtc 2940 acatgcgtgg tggtggacgt
gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 3000 gacggcgtgg
aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 3060
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac
3120 aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat
ctccaaagcc 3180 aaagggcagc cccgagaacc acaggtgtac accctgcccc
catcccgcga tgagctgacc 3240 aagaaccagg tcagcctgac ctgcctggtc
aaaggcttct atcccagcga catcgccgtg 3300 gagtgggaga gcaatgggca
gccggagaac aactacaaga ccacgcctcc cgtgttggac 3360 tccgacggct
ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 3420
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag
3480 agcctctccc tgtctccggg taaatga 3507 <210> SEQ ID NO 129
<211> LENGTH: 1168 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-028 amino acid
sequence <400> SEQUENCE: 129 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Glu
Val Gln Leu Val Gln Ser Gly Ala Glu Val 20 25 30 Asn Lys Pro Gly
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 35 40 45 Thr Phe
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 50 55 60
Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 65
70 75 80 Tyr Ala Gln Lys Phe Gln Gly Trp Val Thr Met Thr Arg Asp
Thr Ser 85 90 95 Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
Ser Asp Asp Thr 100 105 110 Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ala
Leu Tyr Asn Arg Asn Asp 115 120 125 Arg Ser Pro Asn Trp Phe Asp Pro
Trp Gly Gln Gly Thr Leu Val Thr 130 135 140 Val Ser Ser Gly Ser Ala
Ser Ala Pro Thr Leu Lys Leu Glu Glu Gly 145 150 155 160 Glu Phe Ser
Glu Ala Arg Val Gln Ala Val Leu Thr Gln Pro Pro Ser 165 170 175 Val
Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 180 185
190 Asn Ile Gly Ser Lys Ser Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln
195 200 205 Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser
Gly Ile 210 215 220 Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Met
Ala Thr Leu Thr 225 230 235 240 Ile Ser Arg Val Glu Ala Gly Asp Glu
Ala Asp Tyr Tyr Cys Gln Val 245 250 255 Trp Asp Ser Ser Ser Asp His
Val Val Phe Gly Gly Gly Thr Lys Leu 260 265 270 Thr Val Leu Gly Gln
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 275 280 285 Pro Ser Ala
Ala Ala Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp 290 295 300 Gly
Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys 305 310
315 320 Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu
Gly 325 330 335 Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys
Val Asn Glu 340 345 350 Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His
Thr Gly Thr Lys Arg 355 360 365 Ser Cys Arg Cys His Glu Gly Tyr Ser
Leu Leu Ala Asp Gly Val Ser 370 375 380 Cys Thr Pro Thr Val Glu Tyr
Pro Cys Gly Lys Ile Pro Ile Leu Glu 385 390 395 400 Lys Arg Asn Ala
Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val 405 410 415 Cys Pro
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly 420 425 430
Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser 435
440 445 Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala 450 455 460 Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly Asp
Glu Gln Ser 465 470 475 480 Arg Arg Val Ala Gln Val Ile Ile Pro Ser
Thr Tyr Val Pro Gly Thr 485 490 495 Thr Asn His Asp Ile Ala Leu Leu
Arg Leu His Gln Pro Val Val Leu 500 505 510 Thr Asp His Val Val Pro
Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu 515 520 525 Arg Thr Leu Ala
Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln 530 535 540 Leu Leu
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val 545 550 555
560 Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly
565 570 575 Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr
Ser Asp 580 585 590 Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly
Pro His Ala Thr 595 600 605 His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly
Ile Val Ser Trp Gly Gln 610 615 620 Gly Cys Ala Thr Val Gly His Phe
Gly Val Tyr Thr Arg Val Ser Gln 625 630 635 640 Tyr Ile Glu Trp Leu
Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly 645 650 655 Val Leu Leu
Arg Ala Pro Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly 660 665 670 Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 675 680
685 Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
690 695 700 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys 705 710 715 720 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val 725 730 735 Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr 740 745 750 Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu 755 760 765 Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His 770 775 780 Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 785 790 795 800
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 805
810 815 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu 820 825 830 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro 835 840 845 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn 850 855 860 Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu 865 870 875 880 Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 885 890 895 Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 900 905 910 Lys Ser
Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 915 920 925
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 930
935 940 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser 945 950 955 960 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg 965 970 975 Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro 980 985 990 Glu Val Lys Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala
995 1000 1005 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val 1010 1015 1020 Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys 1025 1030 1035 Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 1040 1045 1050 Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln 1055 1060 1065 Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 1070 1075 1080 Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 1085 1090 1095 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 1100 1105
1110 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
1115 1120 1125 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val 1130 1135 1140 Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr Thr 1145 1150 1155 Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 1160 1165 <210> SEQ ID NO 130 <211> LENGTH: 2868
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence FVII-039 <400> SEQUENCE: 130
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
ggcggaggag acttcactcg ggttgtgggg 600 ggcaaggtgt gccccaaagg
ggagtgtcca tggcaggtcc tgttgttggt gaatggagct 660 cagttgtgtg
gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc 720
gacaaaatca agaactggag gaacctgatc gcggtgctgg gcgagcacga cctcagcgag
780 cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag
cacgtacgtc 840 ccgggcacca ccaaccacga catcgcgctg ctccgcctgc
accagcccgt ggtcctcact 900 gaccatgtgg tgcccctctg cctgcccgaa
cggacgttct ctgagaggac gctggccttc 960 gtgcgcttct cattggtcag
cggctggggc cagctgctgg accgtggcgc cacggccctg 1020 gagctcatgg
tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg 1080
aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc
1140 agcaaggact cctgcaaggg ggacagtgga ggcccacatg ccacccacta
ccggggcacg 1200 tggtacctga cgggcatcgt cagctggggc cagggctgcg
caaccgtggg ccactttggg 1260 gtgtacacca gggtctccca gtacatcgag
tggctgcaaa agctcatgcg ctcagagcca 1320 cgcccaggag tcctcctgcg
agccccattt cccggtggcg gtggctccgg cggaggtggg 1380 tccggtggcg
gcggatcagg tgggggtgga tcaggcggtg gaggttccgg tggcggggga 1440
tccgacaaaa ctcacacatg cccaccgtgc ccagctccgg aactcctggg cggaccgtca
1500 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac
ccctgaggtc 1560 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg
tcaagttcaa ctggtacgtg 1620 gacggcgtgg aggtgcataa tgccaagaca
aagccgcggg aggagcagta caacagcacg 1680 taccgtgtgg tcagcgtcct
caccgtcctg caccaggact ggctgaatgg caaggagtac 1740 aagtgcaagg
tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1800
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc
1860 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga
catcgccgtg 1920 gagtgggaga gcaatgggca gccggagaac aactacaaga
ccacgcctcc cgtgttggac 1980 tccgacggct ccttcttcct ctacagcaag
ctcaccgtgg acaagagcag gtggcagcag 2040 gggaacgtct tctcatgctc
cgtgatgcat gaggctctgc acaaccacta cacgcagaag 2100 agcctctccc
tgtctccggg taaaggtggc ggcggatcag gtgggggtgg atcaggcggt 2160
ggaggttccg gtggcggggg atcagacaaa actcacacat gcccaccgtg cccagcacct
2220 gaactcctgg gaggaccgtc agtcttcctc ttccccccaa aacccaagga
caccctcatg 2280 atctcccgga cccctgaggt cacatgcgtg gtggtggacg
tgagccacga agaccctgag 2340 gtcaagttca actggtacgt ggacggcgtg
gaggtgcata atgccaagac aaagccgcgg 2400 gaggagcagt acaacagcac
gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 2460 tggctgaatg
gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 2520
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc
2580 ccatcccgcg atgagctgac caagaaccag gtcagcctga cctgcctggt
caaaggcttc 2640 tatcccagcg acatcgccgt ggagtgggag agcaatgggc
agccggagaa caactacaag 2700 accacgcctc ccgtgttgga ctccgacggc
tccttcttcc tctacagcaa gctcaccgtg 2760 gacaagagca ggtggcagca
ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 2820 cacaaccact
acacgcagaa gagcctctcc ctgtctccgg gtaaatga 2868 <210> SEQ ID
NO 131 <211> LENGTH: 955 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-039 amino acid
sequence <400> SEQUENCE: 131 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Gly 180 185
190 Gly Asp Phe Thr Arg Val Val Gly Gly Lys Val Cys Pro Lys Gly Glu
195 200 205 Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu
Cys Gly 210 215 220 Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala
Ala His Cys Phe 225 230 235 240 Asp Lys Ile Lys Asn Trp Arg Asn Leu
Ile Ala Val Leu Gly Glu His 245 250 255 Asp Leu Ser Glu His Asp Gly
Asp Glu Gln Ser Arg Arg Val Ala Gln 260 265 270 Val Ile Ile Pro Ser
Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile 275 280 285 Ala Leu Leu
Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val 290 295 300 Pro
Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe 305 310
315 320 Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg
Gly 325 330 335 Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg
Leu Met Thr 340 345 350 Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly
Asp Ser Pro Asn Ile 355 360 365 Thr Glu Tyr Met Phe Cys Ala Gly Tyr
Ser Asp Gly Ser Lys Asp Ser 370 375 380 Cys Lys Gly Asp Ser Gly Gly
Pro His Ala Thr His Tyr Arg Gly Thr 385 390 395 400 Trp Tyr Leu Thr
Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val 405 410 415 Gly His
Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu 420 425 430
Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala 435
440 445 Pro Phe Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 450 455 460 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 465 470 475 480 Ser Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu 485 490 495 Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu 500 505 510 Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser 515 520 525
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 530
535 540 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr 545 550 555 560 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn 565 570 575 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro 580 585 590 Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln 595 600 605 Val Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 610 615 620 Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 625 630 635 640 Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 645 650
655 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
660 665 670 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val 675 680 685 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu 690 695 700 Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly 705 710 715 720 Gly Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr His Thr Cys Pro Pro 725 730 735 Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 740 745 750 Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 755 760 765 Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 770 775
780 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
785 790 795 800 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr Val 805 810 815 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser 820 825 830 Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys 835 840 845 Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Asp 850 855 860 Glu Leu Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 865 870 875 880 Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 885 890 895
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 900
905 910 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly 915 920 925 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr 930 935 940 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
945 950 955 <210> SEQ ID NO 132 <211> LENGTH: 2865
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-040 <400> SEQUENCE: 132
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggcggc
ggaggagact tcactcgggt tgtggggggc 600 aaggtgtgcc ccaaagggga
gtgtccatgg caggtcctgt tgttggtgaa tggagctcag 660 ttgtgtgggg
ggaccctgat caacaccatc tgggtggtct ccgcggccca ctgtttcgac 720
aaaatcaaga actggaggaa cctgatcgcg gtgctgggcg agcacgacct cagcgagcac
780 gacggggatg agcagagccg gcgggtggcg caggtcatca tccccagcac
gtacgtcccg 840 ggcaccacca accacgacat cgcgctgctc cgcctgcacc
agcccgtggt cctcactgac 900 catgtggtgc ccctctgcct gcccgaacgg
acgttctctg agaggacgct ggccttcgtg 960 cgcttctcat tggtcagcgg
ctggggccag ctgctggacc gtggcgccac ggccctggag 1020 ctcatggtcc
tcaacgtgcc ccggctgatg acccaggact gcctgcagca gtcacggaag 1080
gtgggagact ccccaaatat cacggagtac atgttctgtg ccggctactc ggatggcagc
1140 aaggactcct gcaaggggga cagtggaggc ccacatgcca cccactaccg
gggcacgtgg 1200 tacctgacgg gcatcgtcag ctggggccag ggctgcgcaa
ccgtgggcca ctttggggtg 1260 tacaccaggg tctcccagta catcgagtgg
ctgcaaaagc tcatgcgctc agagccacgc 1320 ccaggagtcc tcctgcgagc
cccatttccc ggtggcggtg gctccggcgg aggtgggtcc 1380 ggtggcggcg
gatcaggtgg gggtggatca ggcggtggag gttccggtgg cgggggatcc 1440
gacaaaactc acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc
1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc
tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca
agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag
ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac
cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcaaggtct
ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag
1860 aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat
cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca
cgcctcccgt gttggactcc 1980 gacggctcct tcttcctcta cagcaagctc
accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt
gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt
ctccgggtaa aggtggcggc ggatcaggtg ggggtggatc aggcggtgga 2160
ggttccggtg gcgggggatc agacaaaact cacacatgcc caccgtgccc agcacctgaa
2220 ctcctgggag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac
cctcatgatc 2280 tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga
gccacgaaga ccctgaggtc 2340 aagttcaact ggtacgtgga cggcgtggag
gtgcataatg ccaagacaaa gccgcgggag 2400 gagcagtaca acagcacgta
ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 2460 ctgaatggca
aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 2520
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca
2580 tcccgcgatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa
aggcttctat 2640 cccagcgaca tcgccgtgga gtgggagagc aatgggcagc
cggagaacaa ctacaagacc 2700 acgcctcccg tgttggactc cgacggctcc
ttcttcctct acagcaagct caccgtggac 2760 aagagcaggt ggcagcaggg
gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 2820 aaccactaca
cgcagaagag cctctccctg tctccgggta aatga 2865 <210> SEQ ID NO
133 <211> LENGTH: 954 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-040 amino acid
sequence <400> SEQUENCE: 133 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Gly Gly Gly 180 185
190 Asp Phe Thr Arg Val Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys
195 200 205 Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys
Gly Gly 210 215 220 Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala
His Cys Phe Asp 225 230 235 240 Lys Ile Lys Asn Trp Arg Asn Leu Ile
Ala Val Leu Gly Glu His Asp 245 250 255 Leu Ser Glu His Asp Gly Asp
Glu Gln Ser Arg Arg Val Ala Gln Val 260 265 270 Ile Ile Pro Ser Thr
Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala
275 280 285 Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His Val
Val Pro 290 295 300 Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr
Leu Ala Phe Val 305 310 315 320 Arg Phe Ser Leu Val Ser Gly Trp Gly
Gln Leu Leu Asp Arg Gly Ala 325 330 335 Thr Ala Leu Glu Leu Met Val
Leu Asn Val Pro Arg Leu Met Thr Gln 340 345 350 Asp Cys Leu Gln Gln
Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr 355 360 365 Glu Tyr Met
Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys 370 375 380 Lys
Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp 385 390
395 400 Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val
Gly 405 410 415 His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu
Trp Leu Gln 420 425 430 Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val
Leu Leu Arg Ala Pro 435 440 445 Phe Pro Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Asp Lys Thr His
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 485 490 495 Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515
520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His
Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635
640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Lys Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 705 710 715 720 Gly Ser Gly Gly Gly
Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 725 730 735 Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 740 745 750 Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 755 760
765 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
770 775 780 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu 785 790 795 800 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu 805 810 815 His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn 820 825 830 Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly 835 840 845 Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 850 855 860 Leu Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 865 870 875 880
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 885
890 895 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe 900 905 910 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn 915 920 925 Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr 930 935 940 Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 945 950 <210> SEQ ID NO 134 <211> LENGTH: 3107
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FIX-042 <400> SEQUENCE: 134
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta
60 ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata
cattgagtat 120 gcttgccttt tagatataga aatatctgat gctgtcttct
tcactaaatt ttgattacat 180 gatttgacag caatattgaa gagtctaaca
gccagcacgc aggttggtaa gtactgtggg 240 aacatcacag attttggctc
catgccctaa agagaaattg gctttcagat tatttggatt 300 aaaaacaaag
actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa 360
ctaaagaatt attcttttac atttcagttt ttcttgatca tgaaaacgcc aacaaaattc
420 tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa
gggaatctag 480 agagagaatg tatggaagaa aagtgtagtt ttgaagaagc
acgagaagtt tttgaaaaca 540 ctgaaagaac aactgaattt tggaagcagt
atgttgatgg agatcagtgt gagtccaatc 600 catgtttaaa tggcggcagt
tgcaaggatg acattaattc ctatgaatgt tggtgtccct 660 ttggatttga
aggaaagaac tgtgaattag atgtaacatg taacattaag aatggcagat 720
gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt actgagggat
780 atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca
tgtggaagag 840 tttctgtttc acaaacttct aagctcaccc gtgctgagac
tgtttttcct gatgtggact 900 atgtaaattc tactgaagct gaaaccattt
tggataacat cactcaaagc acccaatcat 960 ttaatgactt cactcgggtt
gttggtggag aagatgccaa accaggtcaa ttcccttggc 1020 aggttgtttt
gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat 1080
ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg
1140 aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt
cgaattattc 1200 ctcaccacaa ctacaatgca gctattaata agtacaacca
tgacattgcc cttctggaac 1260 tggacgaacc cttagtgcta aacagctacg
ttacacctat ttgcattgct gacaaggaat 1320 acacgaacat cttcctcaaa
tttggatctg gctatgtaag tggctgggga agagtcttcc 1380 acaaagggag
atcagcttta gttcttcagt accttagagt tccacttgtt gaccgagcca 1440
catgtcttcg atctacaaag ttcaccatct ataacaacat gttctgtgct ggcttccatg
1500 aaggaggtag agattcatgt caaggagata gtgggggacc ccatgttact
gaagtggaag 1560 ggaccagttt cttaactgga attattagct ggggtgaaga
gtgtgcaatg aaaggcaaat 1620 atggaatata taccaaggtg tcccggtatg
tcaactggat taaggaaaaa acaaagctca 1680 ctgacaaaac tcacacatgc
ccaccgtgcc cagctccgga actcctgggc ggaccgtcag 1740 tcttcctctt
ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca 1800
catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg
1860 acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac
aacagcacgt 1920 accgtgtggt cagcgtcctc accgtcctgc accaggactg
gctgaatggc aaggagtaca 1980 agtgcaaggt ctccaacaaa gccctcccag
cccccatcga gaaaaccatc tccaaagcca 2040 aagggcagcc ccgagaacca
caggtgtaca ccctgccccc atcccgggat gagctgacca 2100 agaaccaggt
cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg 2160
agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgttggact
2220 ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg
tggcagcagg 2280 ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca
caaccactac acgcagaaga 2340 gcctctccct gtctccgggt aaaggtggcg
gcggatcagg tgggggtgga tcaggcggtg 2400 gaggttccgg tggcggggga
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg 2460 aactcctggg
aggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga 2520
tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg
2580 tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca
aagccgcggg 2640 aggagcagta caacagcacg taccgtgtgg tcagcgtcct
caccgtcctg caccaggact 2700 ggctgaatgg caaggagtac aagtgcaagg
tctccaacaa agccctccca gcccccatcg 2760 agaaaaccat ctccaaagcc
aaagggcagc cccgagaacc acaggtgtac accctgcccc 2820 catcccgcga
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct 2880
atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga
2940 ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag
ctcaccgtgg 3000 acaagagcag gtggcagcag gggaacgtct tctcatgctc
cgtgatgcat gaggctctgc 3060 acaaccacta cacgcagaag agcctctccc
tgtctccggg taaatga 3107 <210> SEQ ID NO 135 <211>
LENGTH: 935 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: FIX-042 amino acid sequence
<400> SEQUENCE: 135 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly
Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val
Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn
Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg
Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr
Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210
215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro
Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys
Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala
His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly
Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg
Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala
Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu
Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330
335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala
Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met
Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys
Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly
Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys
Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg
Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 450 455
460 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
465 470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555 560 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 565 570 575
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 580
585 590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys 595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680 685 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 690 695 700
Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 705
710 715 720 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys 725 730 735 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val 740 745 750 Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val Asp 755 760 765 Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Tyr 770 775 780 Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp 785 790 795 800 Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 805 810 815 Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 820 825
830 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
835 840 845 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser Asp 850 855 860 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys 865 870 875 880 Thr Thr Pro Pro Val Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr Ser 885 890 895 Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe Ser 900 905 910 Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 915 920 925 Leu Ser Leu
Ser Pro Gly Lys 930 935 <210> SEQ ID NO 136 <211>
LENGTH: 4073 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FIX-068 <400> SEQUENCE:
136 atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat
ctgcctttta 60 ggatatctac tcagtgctga atgtacaggt ttgtttcctt
ttttaaaata cattgagtat 120 gcttgccttt tagatataga aatatctgat
gctgtcttct tcactaaatt ttgattacat 180 gatttgacag caatattgaa
gagtctaaca gccagcacgc aggttggtaa gtactgtggg 240 aacatcacag
attttggctc catgccctaa agagaaattg gctttcagat tatttggatt 300
aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa
360 ctaaagaatt attcttttac atttcagttt ttcttgatca tgaaaacgcc
aacaaaattc 420 tgaatcggcc aaagaggtat aattcaggta aattggaaga
gtttgttcaa gggaatctag 480 agagagaatg tatggaagaa aagtgtagtt
ttgaagaagc acgagaagtt tttgaaaaca 540 ctgaaagaac aactgaattt
tggaagcagt atgttgatgg agatcagtgt gagtccaatc 600 catgtttaaa
tggcggcagt tgcaaggatg acattaattc ctatgaatgt tggtgtccct 660
ttggatttga aggaaagaac tgtgaattag atgtaacatg taacattaag aatggcagat
720 gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt
actgagggat 780 atcgacttgc agaaaaccag aagtcctgtg aaccagcagt
gccatttcca tgtggaagag 840 tttctgtttc acaaacttct aagctcaccc
gtgctgagac tgtttttcct gatgtggact 900 atgtaaattc tactgaagct
gaaaccattt tggataacat cactcaaagc acccaatcat 960 ttaatgactt
cactcgggtt gttggtggag aagatgccaa accaggtcaa ttcccttggc 1020
aggttgtttt gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat
1080 ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt
gtcgcaggtg 1140 aacataatat tgaggagaca gaacatacag agcaaaagcg
aaatgtgatt cgaattattc 1200 ctcaccacaa ctacaatgca gctattaata
agtacaacca tgacattgcc cttctggaac 1260 tggacgaacc cttagtgcta
aacagctacg ttacacctat ttgcattgct gacaaggaat 1320 acacgaacat
cttcctcaaa tttggatctg gctatgtaag tggctgggga agagtcttcc 1380
acaaagggag atcagcttta gttcttcagt accttagagt tccacttgtt gaccgagcca
1440 catgtcttcg atctacaaag ttcaccatct ataacaacat gttctgtgct
ggcttccatg 1500 aaggaggtag agattcatgt caaggagata gtgggggacc
ccatgttact gaagtggaag 1560 ggaccagttt cttaactgga attattagct
ggggtgaaga gtgtgcaatg aaaggcaaat 1620 atggaatata taccaaggtg
tcccggtatg tcaactggat taaggaaaaa acaaagctca 1680 ctgacaaaac
tcacacatgc ccaccgtgcc cagctccgga actcctgggc ggaccgtcag 1740
tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca
1800
catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg
1860 acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac
aacagcacgt 1920 accgtgtggt cagcgtcctc accgtcctgc accaggactg
gctgaatggc aaggagtaca 1980 agtgcaaggt ctccaacaaa gccctcccag
cccccatcga gaaaaccatc tccaaagcca 2040 aagggcagcc ccgagaacca
caggtgtaca ccctgccccc atcccgggat gagctgacca 2100 agaaccaggt
cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg 2160
agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgttggact
2220 ccgacggctc cttcttcctc tacagcaagc tcaccgtcga caagagcagg
tggcagcagg 2280 ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca
caaccactac acgcagaaga 2340 gcctctccct gtctccgggt aaacggcgcc
gccggagcgg tggcggcgga tcaggtgggg 2400 gtggatcagg cggtggaggt
tccggtggcg ggggatccgg cggtggaggt tccggtgggg 2460 gtggatcaag
gaagaggagg aagagggcgc aggtgcagct gcaggagtct gggggaggct 2520
tggtacagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc atgtttagca
2580 ggtatgccat gagctgggtc cgccaggctc cagggaaggg gccagagtgg
gtctcaggta 2640 ttagtggtag tggtggtagt acatactacg cagactccgt
gaagggccgg ttcaccgtct 2700 ccagagacaa ttccaagaac acgctgtatc
tgcaaatgaa cagcctgaga gccgaggaca 2760 cggctgtata ttactgcgcc
cggggcgcca cctacaccag ccggagcgac gtgcccgacc 2820 agaccagctt
cgactactgg ggccagggaa ccctggtcac cgtctcctca gggagtgcat 2880
ccgccccaaa gcttgaagaa ggtgaatttt cagaagcacg cgtatctgaa ctgactcagg
2940 accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa
ggagacagcc 3000 tcagaaactt ttatgcaagc tggtaccagc agaagccagg
acaggcccct actcttgtca 3060 tctatggttt aagtaaaagg ccctcaggga
tcccagaccg attctctgcc tccagctcag 3120 gaaacacagc ttccttgacc
atcactgggg ctcaggcgga agatgaggct gactattact 3180 gcctgctgta
ctacggcggc ggccagcagg gcgtgttcgg cggcggcacc aagctgaccg 3240
tcctacgtca gcccaaggct gccccctcgg tcactctgtt cccgccctct tctgcggccg
3300 gtggcggtgg ctccggcgga ggtgggtccg gtggcggcgg atcaggtggg
ggtggatcag 3360 gcggtggagg ttccggtggc gggggatcag acaaaactca
cacatgccca ccgtgcccag 3420 caccggaact cctgggcgga ccgtcagtct
tcctcttccc cccaaaaccc aaggacaccc 3480 tcatgatctc ccggacccct
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc 3540 ctgaggtcaa
gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc 3600
cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc
3660 aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc
ctcccagccc 3720 ccatcgagaa aaccatctcc aaagccaaag ggcagccccg
agaaccacag gtgtacaccc 3780 tgcccccatc ccgcgatgag ctgaccaaga
accaggtcag cctgacctgc ctggtcaaag 3840 gcttctatcc cagcgacatc
gccgtggagt gggagagcaa tgggcagccg gagaacaact 3900 acaagaccac
gcctcccgtg ttggactccg acggctcctt cttcctctac agcaagctca 3960
ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg
4020 ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa tga
4073 <210> SEQ ID NO 137 <211> LENGTH: 1257 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct:
FIX-068 amino acid sequence <400> SEQUENCE: 137 Met Gln Arg
Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile
Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25
30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu
Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln
Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn
Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp
Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val
Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys
Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155
160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser
Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr
Gln Ser Phe Asn Asp Phe 210 215 220 Thr Arg Val Val Gly Gly Glu Asp
Ala Lys Pro Gly Gln Phe Pro Trp 225 230 235 240 Gln Val Val Leu Asn
Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val Asn Glu
Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 260 265 270 Val
Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 275 280
285 His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
290 295 300 Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
Leu Glu 305 310 315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val
Thr Pro Ile Cys Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe
Leu Lys Phe Gly Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly Arg Val
Phe His Lys Gly Arg Ser Ala Leu Val 355 360 365 Leu Gln Tyr Leu Arg
Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 370 375 380 Ser Thr Lys
Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 385 390 395 400
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 405
410 415 Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp
Gly 420 425 430 Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
Lys Val Ser 435 440 445 Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys
Leu Thr Asp Lys Thr 450 455 460 His Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser 465 470 475 480 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 485 490 495 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 500 505 510 Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 515 520 525
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 530
535 540 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr 545 550 555 560 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 565 570 575 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 580 585 590 Pro Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys 595 600 605 Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 610 615 620 Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 625 630 635 640 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 645 650
655 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
660 665 670 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 675 680 685 Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly 705 710 715 720 Gly Gly Ser Arg Lys Arg Arg
Lys Arg Ala Gln Val Gln Leu Gln Glu 725 730 735 Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 740 745 750 Ala Ala Ser
Gly Phe Met Phe Ser Arg Tyr Ala Met Ser Trp Val Arg 755 760 765 Gln
Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile Ser Gly Ser 770 775
780 Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val
785 790 795 800 Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met
Asn Ser Leu 805 810 815 Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
Arg Gly Ala Thr Tyr 820 825 830 Thr Ser Arg Ser Asp Val Pro Asp Gln
Thr Ser Phe Asp Tyr Trp Gly 835 840 845 Gln Gly Thr Leu Val Thr Val
Ser Ser Gly Ser Ala Ser Ala Pro Lys 850 855 860 Leu Glu Glu Gly Glu
Phe Ser Glu Ala Arg Val Ser Glu Leu Thr Gln 865 870 875 880
Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 885
890 895 Gln Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser Trp Tyr Gln Gln
Lys 900 905 910 Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser
Lys Arg Pro 915 920 925 Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser
Ser Gly Asn Thr Ala 930 935 940 Ser Leu Thr Ile Thr Gly Ala Gln Ala
Glu Asp Glu Ala Asp Tyr Tyr 945 950 955 960 Cys Leu Leu Tyr Tyr Gly
Gly Gly Gln Gln Gly Val Phe Gly Gly Gly 965 970 975 Thr Lys Leu Thr
Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr 980 985 990 Leu Phe
Pro Pro Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 995 1000
1005 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
1010 1015 1020 Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys
Pro Pro 1025 1030 1035 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu Phe 1040 1045 1050 Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu 1055 1060 1065 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val 1070 1075 1080 Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala Lys 1085 1090 1095 Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 1100 1105 1110 Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 1115 1120
1125 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
1130 1135 1140 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val 1145 1150 1155 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val 1160 1165 1170 Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala 1175 1180 1185 Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr 1190 1195 1200 Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 1205 1210 1215 Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 1220 1225 1230 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 1235 1240
1245 Lys Ser Leu Ser Leu Ser Pro Gly Lys 1250 1255 <210> SEQ
ID NO 138 <211> LENGTH: 4010 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: DNA sequence
for FIX-088 <400> SEQUENCE: 138 atgcagcgcg tgaacatgat
catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac
tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat
180 gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa
gtactgtggg 240 aacatcacag attttggctc catgccctaa agagaaattg
gctttcagat tatttggatt 300 aaaaacaaag actttcttaa gagatgtaaa
attttcatga tgttttcttt tttgctaaaa 360 ctaaagaatt attcttttac
atttcagttt ttcttgatca tgaaaacgcc aacaaaattc 420 tgaatcggcc
aaagaggtat aattcaggta aattggaaga gtttgttcaa gggaatctag 480
agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt tttgaaaaca
540 ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt
gagtccaatc 600 catgtttaaa tggcggcagt tgcaaggatg acattaattc
ctatgaatgt tggtgtccct 660 ttggatttga aggaaagaac tgtgaattag
atgtaacatg taacattaag aatggcagat 720 gcgagcagtt ttgtaaaaat
agtgctgata acaaggtggt ttgctcctgt actgagggat 780 atcgacttgc
agaaaaccag aagtcctgtg aaccagcagt gccatttcca tgtggaagag 840
tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct gatgtggact
900 atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc
acccaatcat 960 ttaatgactt cactcgggtt gttggtggag aagatgccaa
accaggtcaa ttcccttggc 1020 aggttgtttt gaatggtaaa gttgatgcat
tctgtggagg ctctatcgtt aatgaaaaat 1080 ggattgtaac tgctgcccac
tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg 1140 aacataatat
tgaggagaca gaacatacag agcaaaagcg aaatgtgatt cgaattattc 1200
ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc cttctggaac
1260 tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct
gacaaggaat 1320 acacgaacat cttcctcaaa tttggatctg gctatgtaag
tggctgggga agagtcttcc 1380 acaaagggag atcagcttta gttcttcagt
accttagagt tccacttgtt gaccgagcca 1440 catgtcttcg atctacaaag
ttcaccatct ataacaacat gttctgtgct ggcttccatg 1500 aaggaggtag
agattcatgt caaggagata gtgggggacc ccatgttact gaagtggaag 1560
ggaccagttt cttaactgga attattagct ggggtgaaga gtgtgcaatg aaaggcaaat
1620 atggaatata taccaaggtg tcccggtatg tcaactggat taaggaaaaa
acaaagctca 1680 ctgacaaaac tcacacatgc ccaccgtgcc cagctccgga
actcctgggc ggaccgtcag 1740 tcttcctctt ccccccaaaa cccaaggaca
ccctcatgat ctcccggacc cctgaggtca 1800 catgcgtggt ggtggacgtg
agccacgaag accctgaggt caagttcaac tggtacgtgg 1860 acggcgtgga
ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt 1920
accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca
1980 agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc
tccaaagcca 2040 aagggcagcc ccgagaacca caggtgtaca ccctgccccc
atcccgggat gagctgacca 2100 agaaccaggt cagcctgacc tgcctggtca
aaggcttcta tcccagcgac atcgccgtgg 2160 agtgggagag caatgggcag
ccggagaaca actacaagac cacgcctccc gtgttggact 2220 ccgacggctc
cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg 2280
ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga
2340 gcctctccct gtctccgggt aaaggtggcg gcggatcagg tgggggtgga
tcaggcggtg 2400 gaggttccgg tggcggggga tcagacaaaa ctcacacatg
cccaccgtgc ccagcacctg 2460 aactcctggg aggaccgtca gtcttcctct
tccccccaaa acccaaggac accctcatga 2520 tctcccggac ccctgaggtc
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg 2580 tcaagttcaa
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg 2640
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact
2700 ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca
gcccccatcg 2760 agaaaaccat ctccaaagcc aaagggcagc cccgagaacc
acaggtgtac accctgcccc 2820 catcccgcga tgagctgacc aagaaccagg
tcagcctgac ctgcctggtc aaaggcttct 2880 atcccagcga catcgccgtg
gagtgggaga gcaatgggca gccggagaac aactacaaga 2940 ccacgcctcc
cgtgttggac tccgacggct ccttcttcct ctacagcaag ctcaccgtcg 3000
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc
3060 acaaccacta cacgcagaag agcctctccc tgtctccggg taaaggtggc
ggtggctccg 3120 gcggaggtgg gtccggtggc ggcggatcag gtgggggtgg
atcaggcggt ggaggttccg 3180 gtggcggggg atcagcgcag gtgcagctgc
aggagtctgg gggaggcttg gtacagcctg 3240 gggggtccct gagactctcc
tgtgcagcct ctggattcat gtttagcagg tatgccatga 3300 gctgggtccg
ccaggctcca gggaaggggc cagagtgggt ctcaggtatt agtggtagtg 3360
gtggtagtac atactacgca gactccgtga agggccggtt caccgtctcc agagacaatt
3420 ccaagaacac gctgtatctg caaatgaaca gcctgagagc cgaggacacg
gctgtatatt 3480 actgcgcccg gggcgccacc tacaccagcc ggagcgacgt
gcccgaccag accagcttcg 3540 actactgggg ccagggaacc ctggtcaccg
tctcctcagg gagtgcatcc gccccaaagc 3600 ttgaagaagg tgaattttca
gaagcacgcg tatctgaact gactcaggac cctgctgtgt 3660 ctgtggcctt
gggacagaca gtcaggatca catgccaagg agacagcctc agaaactttt 3720
atgcaagctg gtaccagcag aagccaggac aggcccctac tcttgtcatc tatggtttaa
3780 gtaaaaggcc ctcagggatc ccagaccgat tctctgcctc cagctcagga
aacacagctt 3840 ccttgaccat cactggggct caggcggaag atgaggctga
ctattactgc ctgctgtact 3900 acggcggcgg ccagcagggc gtgttcggcg
gcggcaccaa gctgaccgtc ctacgtcagc 3960 ccaaggctgc cccctcggtc
actctgttcc cgccctcttc tgcggcctga 4010 <210> SEQ ID NO 139
<211> LENGTH: 1236 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FIX-088 amino acid sequence
<400> SEQUENCE: 139 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile
100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg
Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val Val
Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn Gln
Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg Val
Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr Val
Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205 Thr
Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210 215
220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala His
Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly Glu
His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg Asn
Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala Ile
Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu Asp
Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330 335
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 340
345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu
Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe
Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys Gln
Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly Thr
Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys Ala
Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg Tyr
Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 450 455 460
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 465
470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555 560 Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 565 570 575 Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 580 585
590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680 685 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 690 695 700 Gly
Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 705 710
715 720 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys 725 730 735 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val Val 740 745 750 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp 755 760 765 Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr 770 775 780 Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His Gln Asp 785 790 795 800 Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 805 810 815 Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 820 825 830
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 835
840 845 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp 850 855 860 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys 865 870 875 880 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser 885 890 895 Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser 900 905 910 Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser 915 920 925 Leu Ser Leu Ser
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 930 935 940 Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 945 950 955
960 Gly Gly Gly Gly Ser Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly
965 970 975 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly 980 985 990 Phe Met Phe Ser Arg Tyr Ala Met Ser Trp Val Arg
Gln Ala Pro Gly 995 1000 1005 Lys Gly Pro Glu Trp Val Ser Gly Ile
Ser Gly Ser Gly Gly Ser 1010 1015 1020 Thr Tyr Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr Val Ser Arg 1025 1030 1035 Asp Asn Ser Lys Asn
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 1040 1045 1050 Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr 1055 1060 1065 Thr
Ser Arg Ser Asp Val Pro Asp Gln Thr Ser Phe Asp Tyr Trp 1070 1075
1080 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala
1085 1090 1095 Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val
Ser Glu 1100 1105 1110 Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu
Gly Gln Thr Val 1115 1120 1125 Arg Ile Thr Cys Gln Gly Asp Ser Leu
Arg Asn Phe Tyr Ala Ser 1130 1135 1140 Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Thr Leu Val Ile Tyr 1145 1150 1155 Gly Leu Ser Lys Arg
Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala 1160 1165 1170 Ser Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 1175 1180 1185 Ala
Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly 1190 1195
1200 Gly Gln Gln Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1205 1210 1215 Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro
Pro Ser 1220 1225 1230 Ser Ala Ala 1235 <210> SEQ ID NO 140
<211> LENGTH: 3263 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: DNA sequence for FIX-089
<400> SEQUENCE: 140 atgcagcgcg tgaacatgat catggcagaa
tcaccaggcc tcatcaccat ctgcctttta 60 ggatatctac tcagtgctga
atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120 gcttgccttt
tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg
240 aacatcacag attttggctc catgccctaa agagaaattg gctttcagat
tatttggatt 300 aaaaacaaag actttcttaa gagatgtaaa attttcatga
tgttttcttt tttgctaaaa 360 ctaaagaatt attcttttac atttcagttt
ttcttgatca tgaaaacgcc aacaaaattc 420 tgaatcggcc aaagaggtat
aattcaggta aattggaaga gtttgttcaa gggaatctag 480 agagagaatg
tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt tttgaaaaca 540
ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt gagtccaatc
600 catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt
tggtgtccct 660
ttggatttga aggaaagaac tgtgaattag atgtaacatg taacattaag aatggcagat
720 gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt
actgagggat 780 atcgacttgc agaaaaccag aagtcctgtg aaccagcagt
gccatttcca tgtggaagag 840 tttctgtttc acaaacttct aagctcaccc
gtgctgagac tgtttttcct gatgtggact 900 atgtaaattc tactgaagct
gaaaccattt tggataacat cactcaaagc acccaatcat 960 ttaatgactt
cactcgggtt gttggtggag aagatgccaa accaggtcaa ttcccttggc 1020
aggttgtttt gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat
1080 ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt
gtcgcaggtg 1140 aacataatat tgaggagaca gaacatacag agcaaaagcg
aaatgtgatt cgaattattc 1200 ctcaccacaa ctacaatgca gctattaata
agtacaacca tgacattgcc cttctggaac 1260 tggacgaacc cttagtgcta
aacagctacg ttacacctat ttgcattgct gacaaggaat 1320 acacgaacat
cttcctcaaa tttggatctg gctatgtaag tggctgggga agagtcttcc 1380
acaaagggag atcagcttta gttcttcagt accttagagt tccacttgtt gaccgagcca
1440 catgtcttcg atctacaaag ttcaccatct ataacaacat gttctgtgct
ggcttccatg 1500 aaggaggtag agattcatgt caaggagata gtgggggacc
ccatgttact gaagtggaag 1560 ggaccagttt cttaactgga attattagct
ggggtgaaga gtgtgcaatg aaaggcaaat 1620 atggaatata taccaaggtg
tcccggtatg tcaactggat taaggaaaaa acaaagctca 1680 ctgacaaaac
tcacacatgc ccaccgtgcc cagctccgga actcctggga ggaccgtcag 1740
tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca
1800 catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac
tggtacgtgg 1860 acggcgtgga ggtgcataat gccaagacaa agccgcggga
ggagcagtac aacagcacgt 1920 accgtgtggt cagcgtcctc accgtcctgc
accaggactg gctgaatggc aaggagtaca 1980 agtgcaaggt ctccaacaaa
gccctcccag cccccatcga gaaaaccatc tccaaagcca 2040 aagggcagcc
ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca 2100
agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg
2160 agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc
gtgttggact 2220 ccgacggctc cttcttcctc tacagcaagc tcaccgtcga
caagagcagg tggcagcagg 2280 ggaacgtctt ctcatgctcc gtgatgcatg
aggctctgca caaccactac acgcagaaga 2340 gcctctccct gtctccgggt
aaaggcggtg gcggttcagg tggaggaggg tcaggcggtg 2400 gtggatccgg
cgggggcgga tccggtggcg gagggtcagg cggtggcgga tcagcctgca 2460
ccgagcggat ggccctgcac aacctgtgcg gtggcggtgg ctccggcgga ggtgggtccg
2520 gtggcggcgg atcaggtggg ggtggatcag gcggtggagg ttccggtggc
gggggatccg 2580 acaaaactca cacatgccca ccgtgcccag caccggaact
cctgggcgga ccgtcagtct 2640 tcctcttccc cccaaaaccc aaggacaccc
tcatgatctc ccggacccct gaggtcacat 2700 gcgtggtggt ggacgtgagc
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg 2760 gcgtggaggt
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc 2820
gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt
2880 gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc
aaagccaaag 2940 ggcagccccg agaaccacag gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga 3000 accaggtcag cctgacctgc ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt 3060 gggagagcaa tgggcagccg
gagaacaact acaagaccac gcctcccgtg ttggactccg 3120 acggctcctt
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga 3180
acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc
3240 tctccctgtc tccgggtaaa tga 3263 <210> SEQ ID NO 141
<211> LENGTH: 987 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct: FIX-089 amino acid sequence
<400> SEQUENCE: 141 Met Gln Arg Val Asn Met Ile Met Ala Glu
Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu
Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn
Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu
Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu
Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85
90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp
Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly
Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val
Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn
Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg
Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr
Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210
215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro
Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys
Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala
His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly
Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg
Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala
Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu
Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330
335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala
Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met
Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys
Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly
Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys
Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg
Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 450 455
460 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
465 470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555 560 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 565 570 575
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 580
585 590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys 595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680 685 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 690 695 700
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys 705
710 715 720 Thr Glu Arg Met Ala Leu His Asn Leu Cys Gly Gly Gly Gly
Ser Gly 725 730 735 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 740 745 750 Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys
Thr His Thr Cys Pro Pro 755 760 765 Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro 770 775 780 Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr 785 790 795 800 Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 805 810 815
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 820
825 830 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val 835 840 845 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser 850 855 860 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys 865 870 875 880 Gly Gln Pro Arg Glu Pro Gln Val
Tyr Thr Leu Pro Pro Ser Arg Asp 885 890 895 Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe 900 905 910 Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 915 920 925 Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 930 935 940
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 945
950 955 960 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
His Tyr 965 970 975 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 980
985 <210> SEQ ID NO 142 <211> LENGTH: 2588 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FIX-090 <400> SEQUENCE: 142 atgcagcgcg
tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat
120 gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt
ttgattacat 180 gatttgacag caatattgaa gagtctaaca gccagcacgc
aggttggtaa gtactgtggg 240 aacatcacag attttggctc catgccctaa
agagaaattg gctttcagat tatttggatt 300 aaaaacaaag actttcttaa
gagatgtaaa attttcatga tgttttcttt tttgctaaaa 360 ctaaagaatt
attcttttac atttcagttt ttcttgatca tgaaaacgcc aacaaaattc 420
tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa gggaatctag
480 agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt
tttgaaaaca 540 ctgaaagaac aactgaattt tggaagcagt atgttgatgg
agatcagtgt gagtccaatc 600 catgtttaaa tggcggcagt tgcaaggatg
acattaattc ctatgaatgt tggtgtccct 660 ttggatttga aggaaagaac
tgtgaattag atgtaacatg taacattaag aatggcagat 720 gcgagcagtt
ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt actgagggat 780
atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca tgtggaagag
840 tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct
gatgtggact 900 atgtaaattc tactgaagct gaaaccattt tggataacat
cactcaaagc acccaatcat 960 ttaatgactt cactcgggtt gttggtggag
aagatgccaa accaggtcaa ttcccttggc 1020 aggttgtttt gaatggtaaa
gttgatgcat tctgtggagg ctctatcgtt aatgaaaaat 1080 ggattgtaac
tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt gtcgcaggtg 1140
aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt cgaattattc
1200 ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc
cttctggaac 1260 tggacgaacc cttagtgcta aacagctacg ttacacctat
ttgcattgct gacaaggaat 1320 acacgaacat cttcctcaaa tttggatctg
gctatgtaag tggctgggga agagtcttcc 1380 acaaagggag atcagcttta
gttcttcagt accttagagt tccacttgtt gaccgagcca 1440 catgtcttcg
atctacaaag ttcaccatct ataacaacat gttctgtgct ggcttccatg 1500
aaggaggtag agattcatgt caaggagata gtgggggacc ccatgttact gaagtggaag
1560 ggaccagttt cttaactgga attattagct ggggtgaaga gtgtgcaatg
aaaggcaaat 1620 atggaatata taccaaggtg tcccggtatg tcaactggat
taaggaaaaa acaaagctca 1680 ctggtggcgg tggctccggc ggaggtgggt
ccggtggcgg cggatcaggt gggggtggat 1740 caggcggtgg aggttccggt
ggcgggggat cagcgcaggt gcagctgcag gagtctgggg 1800 gaggcttggt
acagcctggg gggtccctga gactctcctg tgcagcctct ggattcatgt 1860
ttagcaggta tgccatgagc tgggtccgcc aggctccagg gaaggggcca gagtgggtct
1920 caggtattag tggtagtggt ggtagtacat actacgcaga ctccgtgaag
ggccggttca 1980 ccgtctccag agacaattcc aagaacacgc tgtatctgca
aatgaacagc ctgagagccg 2040 aggacacggc tgtatattac tgcgcccggg
gcgccaccta caccagccgg agcgacgtgc 2100 ccgaccagac cagcttcgac
tactggggcc agggaaccct ggtcaccgtc tcctcaggga 2160 gtgcatccgc
cccaaagctt gaagaaggtg aattttcaga agcacgcgta tctgaactga 2220
ctcaggaccc tgctgtgtct gtggccttgg gacagacagt caggatcaca tgccaaggag
2280 acagcctcag aaacttttat gcaagctggt accagcagaa gccaggacag
gcccctactc 2340 ttgtcatcta tggtttaagt aaaaggccct cagggatccc
agaccgattc tctgcctcca 2400 gctcaggaaa cacagcttcc ttgaccatca
ctggggctca ggcggaagat gaggctgact 2460 attactgcct gctgtactac
ggcggcggcc agcagggcgt gttcggcggc ggcaccaagc 2520 tgaccgtcct
acgtcagccc aaggctgccc cctcggtcac tctgttcccg ccctcttctg 2580
cggcctga 2588 <210> SEQ ID NO 143 <211> LENGTH: 762
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FIX-90 amino acid sequence <400> SEQUENCE: 143 Met
Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10
15 Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
20 25 30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg
Tyr Asn 35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu
Glu Arg Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala
Arg Glu Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp
Lys Gln Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys
Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu
Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu
Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145
150 155 160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
Pro Phe 165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys
Leu Thr Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val
Asn Ser Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln
Ser Thr Gln Ser Phe Asn Asp Phe 210 215 220 Thr Arg Val Val Gly Gly
Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 225 230 235 240 Gln Val Val
Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val
Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 260 265
270 Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
275 280 285 His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
His Asn 290 295 300 Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile
Ala Leu Leu Glu 305 310 315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser
Tyr Val Thr Pro Ile Cys Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn
Ile Phe Leu Lys Phe Gly Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly
Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 355 360 365 Leu Gln Tyr
Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 370 375 380 Ser
Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 385 390
395 400 Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His
Val 405 410 415 Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
Ser Trp Gly 420 425 430 Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile
Tyr Thr Lys Val Ser 435 440 445 Arg Tyr Val Asn Trp Ile Lys Glu Lys
Thr Lys Leu Thr Gly Gly Gly 450 455 460 Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470 475 480 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ala Gln Val Gln Leu 485 490 495 Gln Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 500 505 510
Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Arg Tyr Ala Met Ser Trp 515
520 525 Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile
Ser 530 535 540 Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
Gly Arg Phe 545 550 555 560 Thr Val Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr Leu Gln Met Asn 565 570 575
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala 580
585 590 Thr Tyr Thr Ser Arg Ser Asp Val Pro Asp Gln Thr Ser Phe Asp
Tyr 595 600 605 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser
Ala Ser Ala 610 615 620 Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala
Arg Val Ser Glu Leu 625 630 635 640 Thr Gln Asp Pro Ala Val Ser Val
Ala Leu Gly Gln Thr Val Arg Ile 645 650 655 Thr Cys Gln Gly Asp Ser
Leu Arg Asn Phe Tyr Ala Ser Trp Tyr Gln 660 665 670 Gln Lys Pro Gly
Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser Lys 675 680 685 Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser Ser Gly Asn 690 695 700
Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 705
710 715 720 Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly Gln Gln Gly Val
Phe Gly 725 730 735 Gly Gly Thr Lys Leu Thr Val Leu Arg Gln Pro Lys
Ala Ala Pro Ser 740 745 750 Val Thr Leu Phe Pro Pro Ser Ser Ala Ala
755 760 <210> SEQ ID NO 144 <211> LENGTH: 3744
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: DNA sequence for FVII-088 <400> SEQUENCE: 144
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct
60 gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg
gcgcgccaac 120 gcgttcctgg aggagctgcg gccgggctcc ctggagaggg
agtgcaagga ggagcagtgc 180 tccttcgagg aggcccggga gatcttcaag
gacgcggaga ggacgaagct gttctggatt 240 tcttacagtg atggggacca
gtgtgcctca agtccatgcc agaatggggg ctcctgcaag 300 gaccagctcc
agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag 360
acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc
420 agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc
tctgctggca 480 gacggggtgt cctgcacacc cacagttgaa tatccatgtg
gaaaaatacc tattctagaa 540 aaaagaaatg ccagcaaacc ccaaggccga
attgtggggg gcaaggtgtg ccccaaaggg 600 gagtgtccat ggcaggtcct
gttgttggtg aatggagctc agttgtgtgg ggggaccctg 660 atcaacacca
tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg 720
aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc
780 cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac
caaccacgac 840 atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg
accatgtggt gcccctctgc 900 ctgcccgaac ggacgttctc tgagaggacg
ctggccttcg tgcgcttctc attggtcagc 960 ggctggggcc agctgctgga
ccgtggcgcc acggccctgg agctcatggt cctcaacgtg 1020 ccccggctga
tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat 1080
atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg
1140 gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac
gggcatcgtc 1200 agctggggcc agggctgcgc aaccgtgggc cactttgggg
tgtacaccag ggtctcccag 1260 tacatcgagt ggctgcaaaa gctcatgcgc
tcagagccac gcccaggagt cctcctgcga 1320 gccccatttc ccggtggcgg
tggctccggc ggaggtgggt ccggtggcgg cggatcaggt 1380 gggggtggat
caggcggtgg aggttccggt ggcgggggat ccgacaaaac tcacacatgc 1440
ccaccgtgcc cagctccgga actcctggga ggaccgtcag tcttcctctt ccccccaaaa
1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt
ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg
acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac
aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 1740 gccctcccag
cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc
1860 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag
caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgttggact
ccgacggctc cttcttcctc 1980 tacagcaagc tcaccgtcga caagagcagg
tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca
caaccactac acgcagaaga gcctctccct gtctccgggt 2100 aaacggcgcc
gccggagcgg tggcggcgga tcaggtgggg gtggatcagg cggtggaggt 2160
tccggtggcg ggggatccgg cggtggaggt tccggtgggg gtggatcaag gaagaggagg
2220 aagagggaca tcgtgatgac ccaggccgcc cccagcgtgc ccgtgacccc
cggcgagagc 2280 gtgagcatca gctgccggag cagccggagc ctgctgcaca
gcaacggcaa cacctacctg 2340 tgctggttcc tgcagcggcc cggccagagc
ccccagctgc tgatctaccg gatgagcaac 2400 ctggccagcg gcgtgcccga
ccggttcagc ggcagcggca gcggcaccgc cttcaccctg 2460 cggatcagcc
gggtggaggc cgaggacgtg ggcgtgtact actgcatgca gcacctggag 2520
taccccttca ccttcggcag cggcaccaag ctggagatca agcggggcgg cggcggcagc
2580 ggcggcggcg gcagcggcgg cggcggcagc caggtgcagc tgcagcagag
cggcgccgag 2640 ctggtgcggc ccggcaccag cgtgaagatc agctgcaagg
ccagcggcta caccttcacc 2700 aactactggc tgggctgggt gaagcagcgg
cccggccacg gcctggagtg gatcggcgac 2760 atctaccccg gcggcggcta
caacaagtac aacgagaact tcaagggcaa ggccaccctg 2820 accgccgaca
ccagcagcag caccgcctac atgcagctga gcagcctgac cagcgaggac 2880
agcgccgtgt acttctgcgc ccgggagtac ggcaactacg actacgccat ggacagctgg
2940 ggccagggca ccagcgtgac cgtgagcagc ggtggcggtg gctccggcgg
aggtgggtcc 3000 ggtggcggcg gatcaggtgg gggtggatca ggcggtggag
gttccggtgg cgggggatca 3060 gacaaaactc acacatgccc accgtgccca
gcaccggaac tcctgggcgg accgtcagtc 3120 ttcctcttcc ccccaaaacc
caaggacacc ctcatgatct cccggacccc tgaggtcaca 3180 tgcgtggtgg
tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 3240
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac
3300 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa
ggagtacaag 3360 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga
aaaccatctc caaagccaaa 3420 gggcagcccc gagaaccaca ggtgtacacc
ctgcccccat cccgggatga gctgaccaag 3480 aaccaggtca gcctgacctg
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 3540 tgggagagca
atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc 3600
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg
3660 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac
gcagaagagc 3720 ctctccctgt ctccgggtaa atga 3744 <210> SEQ ID
NO 145 <211> LENGTH: 1247 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct: FVII-088 amino acid
sequence <400> SEQUENCE: 145 Met Val Ser Gln Ala Leu Arg Leu
Leu Cys Leu Leu Leu Gly Leu Gln 1 5 10 15 Gly Cys Leu Ala Ala Val
Phe Val Thr Gln Glu Glu Ala His Gly Val 20 25 30 Leu His Arg Arg
Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 35 40 45 Gly Ser
Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 50 55 60
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 65
70 75 80 Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln
Asn Gly 85 90 95 Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys
Phe Cys Leu Pro 100 105 110 Ala Phe Glu Gly Arg Asn Cys Glu Thr His
Lys Asp Asp Gln Leu Ile 115 120 125 Cys Val Asn Glu Asn Gly Gly Cys
Glu Gln Tyr Cys Ser Asp His Thr 130 135 140 Gly Thr Lys Arg Ser Cys
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 145 150 155 160 Asp Gly Val
Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 165 170 175 Pro
Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 180 185
190 Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
195 200 205 Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn
Thr Ile 210 215 220 Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile
Lys Asn Trp Arg 225 230 235 240 Asn Leu Ile Ala Val Leu Gly Glu His
Asp Leu Ser Glu His Asp Gly 245 250 255 Asp Glu Gln Ser Arg Arg Val
Ala Gln Val Ile Ile Pro Ser Thr Tyr 260 265 270 Val Pro Gly Thr Thr
Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 275 280 285 Pro Val Val
Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 290 295 300 Thr
Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 305 310
315 320 Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu
Met 325 330 335 Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu
Gln Gln Ser 340 345 350
Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 355
360 365 Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly
Gly 370 375 380 Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr
Gly Ile Val 385 390 395 400 Ser Trp Gly Gln Gly Cys Ala Thr Val Gly
His Phe Gly Val Tyr Thr 405 410 415 Arg Val Ser Gln Tyr Ile Glu Trp
Leu Gln Lys Leu Met Arg Ser Glu 420 425 430 Pro Arg Pro Gly Val Leu
Leu Arg Ala Pro Phe Pro Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 465 470 475
480 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu 500 505 510 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu 545 550 555 560 Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 565 570 575 Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600
605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys Arg Arg Arg 690 695 700 Arg Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 705 710 715 720
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 725
730 735 Arg Lys Arg Arg Lys Arg Asp Ile Val Met Thr Gln Ala Ala Pro
Ser 740 745 750 Val Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys
Arg Ser Ser 755 760 765 Arg Ser Leu Leu His Ser Asn Gly Asn Thr Tyr
Leu Cys Trp Phe Leu 770 775 780 Gln Arg Pro Gly Gln Ser Pro Gln Leu
Leu Ile Tyr Arg Met Ser Asn 785 790 795 800 Leu Ala Ser Gly Val Pro
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 805 810 815 Ala Phe Thr Leu
Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 820 825 830 Tyr Tyr
Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly 835 840 845
Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 850
855 860 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala
Glu 865 870 875 880 Leu Val Arg Pro Gly Thr Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly 885 890 895 Tyr Thr Phe Thr Asn Tyr Trp Leu Gly Trp
Val Lys Gln Arg Pro Gly 900 905 910 His Gly Leu Glu Trp Ile Gly Asp
Ile Tyr Pro Gly Gly Gly Tyr Asn 915 920 925 Lys Tyr Asn Glu Asn Phe
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr 930 935 940 Ser Ser Ser Thr
Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 945 950 955 960 Ser
Ala Val Tyr Phe Cys Ala Arg Glu Tyr Gly Asn Tyr Asp Tyr Ala 965 970
975 Met Asp Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly
980 985 990 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly 995 1000 1005 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Asp Lys Thr 1010 1015 1020 His Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro 1025 1030 1035 Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile 1040 1045 1050 Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser His 1055 1060 1065 Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 1070 1075 1080 Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 1085 1090
1095 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
1100 1105 1110 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu 1115 1120 1125 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro 1130 1135 1140 Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 1145 1150 1155 Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr 1160 1165 1170 Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 1175 1180 1185 Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 1190 1195 1200 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 1205 1210
1215 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
1220 1225 1230 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 1235 1240 1245 <210> SEQ ID NO 146 <211> LENGTH:
5796 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct: DNA sequence for FVIII-041 <400>
SEQUENCE: 146 atgcaaatag agctctccac ctgcttcttt ctgtgccttt
tgcgattctg ctttagtgcc 60 accagaagat actacctggg tgcagtggaa
ctgtcatggg actatatgca aagtgatctc 120 ggtgagctgc ctgtggacgc
aagatttcct cctagagtgc caaaatcttt tccattcaac 180 acctcagtcg
tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240
gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat
300 gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct
tcatgctgtt 360 ggtgtatcct actggaaagc ttctgaggga gctgaatatg
atgatcagac cagtcaaagg 420 gagaaagaag atgataaagt cttccctggt
ggaagccata catatgtctg gcaggtcctg 480 aaagagaatg gtccaatggc
ctctgaccca ctgtgcctta cctactcata tctttctcat 540 gtggacctgg
taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600
gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta
660 tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca
ggatagggat 720 gctgcatctg ctcgggcctg gcctaaaatg cacacagtca
atggttatgt aaacaggtct 780 ctgccaggtc tgattggatg ccacaggaaa
tcagtctatt ggcatgtgat tggaatgggc 840 accactcctg aagtgcactc
aatattcctc gaaggtcaca catttcttgt gaggaaccat 900 cgccaggcgt
ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960
gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa
1020 gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa
aaataatgaa 1080 gaagcggaag actatgatga tgatcttact gattctgaaa
tggatgtggt caggtttgat 1140 gatgacaact ctccttcctt tatccaaatt
cgctcagttg ccaagaagca tcctaaaact 1200 tgggtacatt acattgctgc
tgaagaggag gactgggact atgctccctt agtcctcgcc 1260 cccgatgaca
gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320
aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct
1380 attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg
agacacactg 1440 ttgattatat ttaagaatca agcaagcaga ccatataaca
tctaccctca cggaatcact 1500 gatgtccgtc ctttgtattc aaggagatta
ccaaaaggtg taaaacattt gaaggatttt 1560 ccaattctgc caggagaaat
attcaaatat aaatggacag tgactgtaga agatgggcca 1620 actaaatcag
atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680
gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa
1740 agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt
atttgatgag 1800 aaccgaagct ggtacctcac agagaatata caacgctttc
tccccaatcc agctggagtg 1860 cagcttgagg atccagagtt ccaagcctcc
aacatcatgc acagcatcaa tggctatgtt 1920 tttgatagtt tgcagttgtc
agtttgtttg catgaggtgg catactggta cattctaagc 1980 attggagcac
agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040
atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg
2100
atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc
2160 atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta
ttacgaggac 2220 agttatgaag atatttcagc atacttgctg agtaaaaaca
atgccattga accaagaagc 2280 ttctctcaaa acccaccagt cttgaaacgc
catcaacggg aaataactcg tactactctt 2340 cagtcagatc aagaggaaat
tgactatgat gataccatat cagttgaaat gaagaaggaa 2400 gattttgaca
tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca 2460
cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca
2520 catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa
agttgttttc 2580 caggaattta ctgatggctc ctttactcag cccttatacc
gtggagaact aaatgaacat 2640 ttgggactcc tggggccata tataagagca
gaagttgaag ataatatcat ggtaactttc 2700 agaaatcagg cctctcgtcc
ctattccttc tattctagcc ttatttctta tgaggaagat 2760 cagaggcaag
gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac 2820
ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg
2880 gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat
tggacccctt 2940 ctggtctgcc acactaacac actgaaccct gctcatggga
gacaagtgac agtacaggaa 3000 tttgctctgt ttttcaccat ctttgatgag
accaaaagct ggtacttcac tgaaaatatg 3060 gaaagaaact gcagggctcc
ctgcaatatc cagatggaag atcccacttt taaagagaat 3120 tatcgcttcc
atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct 3180
caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct
3240 attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa
aatggcactg 3300 tacaatctct atccaggtgt ttttgagaca gtggaaatgt
taccatccaa agctggaatt 3360 tggcgggtgg aatgccttat tggcgagcat
ctacatgctg ggatgagcac actttttctg 3420 gtgtacagca ataagtgtca
gactcccctg ggaatggctt ctggacacat tagagatttt 3480 cagattacag
cttcaggaca atatggacag tgggccccaa agctggccag acttcattat 3540
tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg
3600 ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa
gttctccagc 3660 ctctacatct ctcagtttat catcatgtat agtcttgatg
ggaagaagtg gcagacttat 3720 cgaggaaatt ccactggaac cttaatggtc
ttctttggca atgtggattc atctgggata 3780 aaacacaata tttttaaccc
tccaattatt gctcgataca tccgtttgca cccaactcat 3840 tatagcattc
gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc 3900
atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac
3960 tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct
ccaagggagg 4020 agtaatgcct ggagacctca ggtgaataat ccaaaagagt
ggctgcaagt ggacttccag 4080 aagacaatga aagtcacagg agtaactact
cagggagtaa aatctctgct taccagcatg 4140 tatgtgaagg agttcctcat
ctccagcagt caagatggcc atcagtggac tctctttttt 4200 cagaatggca
aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac 4260
tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac
4320 cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta
cgacaaaact 4380 cacacatgcc caccgtgccc agctccagaa ctcctgggcg
gaccgtcagt cttcctcttc 4440 cccccaaaac ccaaggacac cctcatgatc
tcccggaccc ctgaggtcac atgcgtggtg 4500 gtggacgtga gccacgaaga
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 4560 gtgcataatg
ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 4620
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc
4680 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa
agggcagccc 4740 cgagaaccac aggtgtacac cctgccccca tcccgggatg
agctgaccaa gaaccaggtc 4800 agcctgacct gcctggtcaa aggcttctat
cccagcgaca tcgccgtgga gtgggagagc 4860 aatgggcagc cggagaacaa
ctacaagacc acgcctcccg tgttggactc cgacggctcc 4920 ttcttcctct
acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 4980
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg
5040 tctccgggta aaggtggcgg cggatcaggt gggggtggat caggcggtgg
aggttccggt 5100 ggcgggggat cagacaaaac tcacacatgc ccaccgtgcc
cagcacctga actcctggga 5160 ggaccgtcag tcttcctctt ccccccaaaa
cccaaggaca ccctcatgat ctcccggacc 5220 cctgaggtca catgcgtggt
ggtggacgtg agccacgaag accctgaggt caagttcaac 5280 tggtacgtgg
acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 5340
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc
5400 aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga
gaaaaccatc 5460 tccaaagcca aagggcagcc ccgagaacca caggtgtaca
ccctgccccc atcccgcgat 5520 gagctgacca agaaccaggt cagcctgacc
tgcctggtca aaggcttcta tcccagcgac 5580 atcgccgtgg agtgggagag
caatgggcag ccggagaaca actacaagac cacgcctccc 5640 gtgttggact
ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg 5700
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac
5760 acgcagaaga gcctctccct gtctccgggt aaatga 5796 <210> SEQ
ID NO 147 <211> LENGTH: 1931 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct: FVIII-041 amino
acid sequence <400> SEQUENCE: 147 Met Gln Ile Glu Leu Ser Thr
Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys Phe Ser Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30 Trp Asp Tyr
Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35 40 45 Phe
Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 50 55
60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr
Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys
Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His Ala Val Gly Val
Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu Tyr Asp Asp Gln
Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys Val Phe Pro Gly
Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155 160 Lys Glu Asn
Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165 170 175 Tyr
Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185
190 Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr
195 200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp
Glu Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met
Gln Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg Ala Trp Pro Lys
Met His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg Ser Leu Pro Gly
Leu Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr Trp His Val Ile
Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280 285 Phe Leu Glu
Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 290 295 300 Leu
Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 305 310
315 320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln
His 325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro
Glu Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu
Asp Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu Met Asp Val Val
Arg Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe Ile Gln Ile Arg
Ser Val Ala Lys Lys His Pro Lys Thr 385 390 395 400 Trp Val His Tyr
Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405 410 415 Leu Val
Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 420 425 430
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 435
440 445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His
Glu 450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly
Asp Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg
Pro Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr Asp Val Arg Pro
Leu Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val Lys His Leu Lys
Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525 Lys Tyr Lys Trp
Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530 535 540 Pro Arg
Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 545 550 555
560 Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu
565 570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg
Asn Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp
Tyr Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala
Gly Val Gln Leu Glu Asp
610 615 620 Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly
Tyr Val 625 630 635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His
Glu Val Ala Tyr Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr
Asp Phe Leu Ser Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His
Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser
Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725
730 735 Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser
Lys 740 745 750 Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro
Pro Val Leu 755 760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr
Leu Gln Ser Asp Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile
Ser Val Glu Met Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp
Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr
Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850
855 860 Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu
His 865 870 875 880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val
Glu Asp Asn Ile 885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg
Pro Tyr Ser Phe Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp
Gln Arg Gln Gly Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro
Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala
Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970
975 Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His
980 985 990 Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr
Ile Phe 995 1000 1005 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn
Met Glu Arg Asn 1010 1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met
Glu Asp Pro Thr Phe Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala
Ile Asn Gly Tyr Ile Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val
Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser
Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090
1095 Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met
1100 1105 1110 Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu
Ile Gly 1115 1120 1125 Glu His Leu His Ala Gly Met Ser Thr Leu Phe
Leu Val Tyr Ser 1130 1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met
Ala Ser Gly His Ile Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser
Gly Gln Tyr Gly Gln Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu
His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu
Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210
1215 Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp
1220 1225 1230 Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly
Thr Leu 1235 1240 1245 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly
Ile Lys His Asn 1250 1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg
Tyr Ile Arg Leu His Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser
Thr Leu Arg Met Glu Leu Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser
Cys Ser Met Pro Leu Gly Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser
Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 1325 1330
1335 Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu
1340 1345 1350 Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr
Gly Val 1355 1360 1365 Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser
Met Tyr Val Lys 1370 1375 1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp
Gly His Gln Trp Thr Leu 1385 1390 1395 Phe Phe Gln Asn Gly Lys Val
Lys Val Phe Gln Gly Asn Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val
Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu
Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 1430 1435 1440 Leu
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr Asp 1445 1450
1455 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
1460 1465 1470 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu 1475 1480 1485 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp Val 1490 1495 1500 Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly 1505 1510 1515 Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Tyr 1520 1525 1530 Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln 1535 1540 1545 Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 1550 1555 1560 Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 1565 1570
1575 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
1580 1585 1590 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly 1595 1600 1605 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln 1610 1615 1620 Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp 1625 1630 1635 Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg 1640 1645 1650 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala 1655 1660 1665 Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 1670 1675 1680 Lys
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1685 1690
1695 Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys
1700 1705 1710 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro 1715 1720 1725 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val 1730 1735 1740 Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys 1745 1750 1755 Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr 1760 1765 1770 Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 1775 1780 1785 Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 1790 1795 1800 Lys
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 1805 1810
1815 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
1820 1825 1830 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser 1835 1840 1845 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val 1850 1855 1860 Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys Thr Thr 1865 1870 1875 Pro Pro Val Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr Ser Lys 1880 1885 1890
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 1895
1900 1905 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 1910 1915 1920 Ser Leu Ser Leu Ser Pro Gly Lys 1925 1930
<210> SEQ ID NO 148 <211> LENGTH: 6762 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct: DNA
sequence for FVIII-108 <400> SEQUENCE: 148 atgcaaatag
agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60
accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc
120 ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt
tccattcaac 180 acctcagtcg tgtacaaaaa gactctgttt gtagaattca
cggatcacct tttcaacatc 240 gctaagccaa ggccaccctg gatgggtctg
ctaggtccta ccatccaggc tgaggtttat 300 gatacagtgg tcattacact
taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360 ggtgtatcct
actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420
gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg
480 aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata
tctttctcat 540 gtggacctgg taaaagactt gaattcaggc ctcattggag
ccctactagt atgtagagaa 600 gggagtctgg ccaaggaaaa gacacagacc
ttgcacaaat ttatactact ttttgctgta 660 tttgatgaag ggaaaagttg
gcactcagaa acaaagaact ccttgatgca ggatagggat 720 gctgcatctg
ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780
ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc
840 accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt
gaggaaccat 900 cgccaggcgt ccttggaaat ctcgccaata actttcctta
ctgctcaaac actcttgatg 960 gaccttggac agtttctact gttttgtcat
atctcttccc accaacatga tggcatggaa 1020 gcttatgtca aagtagacag
ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080 gaagcggaag
actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140
gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact
1200 tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt
agtcctcgcc 1260 cccgatgaca gaagttataa aagtcaatat ttgaacaatg
gccctcagcg gattggtagg 1320 aagtacaaaa aagtccgatt tatggcatac
acagatgaaa cctttaagac tcgtgaagct 1380 attcagcatg aatcaggaat
cttgggacct ttactttatg gggaagttgg agacacactg 1440 ttgattatat
ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500
gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt
1560 ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga
agatgggcca 1620 actaaatcag atcctcggtg cctgacccgc tattactcta
gtttcgttaa tatggagaga 1680 gatctagctt caggactcat tggccctctc
ctcatctgct acaaagaatc tgtagatcaa 1740 agaggaaacc agataatgtc
agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800 aaccgaagct
ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860
cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt
1920 tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta
cattctaagc 1980 attggagcac agactgactt cctttctgtc ttcttctctg
gatatacctt caaacacaaa 2040 atggtctatg aagacacact caccctattc
ccattctcag gagaaactgt cttcatgtcg 2100 atggaaaacc caggtctatg
gattctgggg tgccacaact cagactttcg gaacagaggc 2160 atgaccgcct
tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220
agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc
2280 ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg
tactactctt 2340 cagtcagatc aagaggaaat tgactatgat gataccatat
cagttgaaat gaagaaggaa 2400 gattttgaca tttatgatga ggatgaaaat
cagagccccc gcagctttca aaagaaaaca 2460 cgacactatt ttattgctgc
agtggagagg ctctgggatt atgggatgag tagctcccca 2520 catgttctaa
gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc 2580
caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat
2640 ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat
ggtaactttc 2700 agaaatcagg cctctcgtcc ctattccttc tattctagcc
ttatttctta tgaggaagat 2760 cagaggcaag gagcagaacc tagaaaaaac
tttgtcaagc ctaatgaaac caaaacttac 2820 ttttggaaag tgcaacatca
tatggcaccc actaaagatg agtttgactg caaagcctgg 2880 gcttatttct
ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt 2940
ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa
3000 tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac
tgaaaatatg 3060 gaaagaaact gcagggctcc ctgcaatatc cagatggaag
atcccacttt taaagagaat 3120 tatcgcttcc atgcaatcaa tggctacata
atggatacac tacctggctt agtaatggct 3180 caggatcaaa ggattcgatg
gtatctgctc agcatgggca gcaatgaaaa catccattct 3240 attcatttca
gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg 3300
tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt
3360 tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac
actttttctg 3420 gtgtacagca ataagtgtca gactcccctg ggaatggctt
ctggacacat tagagatttt 3480 cagattacag cttcaggaca atatggacag
tgggccccaa agctggccag acttcattat 3540 tccggatcaa tcaatgcctg
gagcaccaag gagccctttt cttggatcaa ggtggatctg 3600 ttggcaccaa
tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc 3660
ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat
3720 cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc
atctgggata 3780 aaacacaata tttttaaccc tccaattatt gctcgataca
tccgtttgca cccaactcat 3840 tatagcattc gcagcactct tcgcatggag
ttgatgggct gtgatttaaa tagttgcagc 3900 atgccattgg gaatggagag
taaagcaata tcagatgcac agattactgc ttcatcctac 3960 tttaccaata
tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg 4020
agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag
4080 aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct
taccagcatg 4140 tatgtgaagg agttcctcat ctccagcagt caagatggcc
atcagtggac tctctttttt 4200 cagaatggca aagtaaaggt ttttcaggga
aatcaagact ccttcacacc tgtggtgaac 4260 tctctagacc caccgttact
gactcgctac cttcgaattc acccccagag ttgggtgcac 4320 cagattgccc
tgaggatgga ggttctgggc tgcgaggcac aggacctcta cgacaaaact 4380
cacacatgcc caccgtgccc agcacctgaa ctcctgggag gaccgtcagt cttcctcttc
4440 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac
atgcgtggtg 4500 gtggacgtga gccacgaaga ccctgaggtc aagttcaact
ggtacgtgga cggcgtggag 4560 gtgcataatg ccaagacaaa gccgcgggag
gagcagtaca acagcacgta ccgtgtggtc 4620 agcgtcctca ccgtcctgca
ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 4680 tccaacaaag
ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 4740
cgagaaccac aggtgtacac cctgccccca tcccgcgatg agctgaccaa gaaccaggtc
4800 agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga
gtgggagagc 4860 aatgggcagc cggagaacaa ctacaagacc acgcctcccg
tgttggactc cgacggctcc 4920 ttcttcctct acagcaagct caccgtcgac
aagagcaggt ggcagcaggg gaacgtcttc 4980 tcatgctccg tgatgcatga
ggctctgcac aaccactaca cgcagaagag cctctccctg 5040 tctccgggta
aacggcgccg ccggagcggt ggcggcggat caggtggggg tggatcaggc 5100
ggtggaggtt ccggtggcgg gggatccggc ggtggaggtt ccggtggggg tggatcaagg
5160 aagaggagga agagggcgca ggtgcagctg caggagtctg ggggaggctt
ggtacagcct 5220 ggggggtccc tgagactctc ctgtgcagcc tctggattca
tgtttagcag gtatgccatg 5280 agctgggtcc gccaggctcc agggaagggg
ccagagtggg tctcaggtat tagtggtagt 5340 ggtggtagta catactacgc
agactccgtg aagggccggt tcaccgtctc cagagacaat 5400 tccaagaaca
cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtatat 5460
tactgcgccc ggggcgccac ctacaccagc cggagcgacg tgcccgacca gaccagcttc
5520 gactactggg gccagggaac cctggtcacc gtctcctcag ggagtgcatc
cgccccaaag 5580 cttgaagaag gtgaattttc agaagcacgc gtatctgaac
tgactcagga ccctgctgtg 5640 tctgtggcct tgggacagac agtcaggatc
acatgccaag gagacagcct cagaaacttt 5700 tatgcaagct ggtaccagca
gaagccagga caggccccta ctcttgtcat ctatggttta 5760 agtaaaaggc
cctcagggat cccagaccga ttctctgcct ccagctcagg aaacacagct 5820
tccttgacca tcactggggc tcaggcggaa gatgaggctg actattactg cctgctgtac
5880 tacggcggcg gccagcaggg cgtgttcggc ggcggcacca agctgaccgt
cctacgtcag 5940 cccaaggctg ccccctcggt cactctgttc ccgccctctt
ctgcggccgg tggcggtggc 6000 tccggcggag gtgggtccgg tggcggcgga
tcaggtgggg gtggatcagg cggtggaggt 6060 tccggtggcg ggggatcaga
caaaactcac acatgcccac cgtgcccagc accggaactc 6120 ctgggcggac
cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 6180
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag
6240 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc
gcgggaggag 6300 cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg
tcctgcacca ggactggctg 6360 aatggcaagg agtacaagtg caaggtctcc
aacaaagccc tcccagcccc catcgagaaa 6420 accatctcca aagccaaagg
gcagccccga gaaccacagg tgtacaccct gcccccatcc 6480 cgggatgagc
tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 6540
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg
6600 cctcccgtgt tggactccga cggctccttc ttcctctaca gcaagctcac
cgtggacaag 6660 agcaggtggc agcaggggaa cgtcttctca tgctccgtga
tgcatgaggc tctgcacaac 6720 cactacacgc agaagagcct ctccctgtct
ccgggtaaat ga 6762 <210> SEQ ID NO 149 <211> LENGTH:
2253 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct: FVIII-108 amino acid sequence <400> SEQUENCE: 149
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5
10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu
Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val
Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe
Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe
Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp
Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp
Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val
Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu
Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135
140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu
145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu
Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu
Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly
Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile
Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser
Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala
Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260
265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser
Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg
Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala
Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe
Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr
Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met
Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr
Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385
390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr
Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser
Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr
Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys
Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro
Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile
Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His
Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505
510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe
515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys
Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val
Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro
Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn
Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val
Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln
Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro
Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630
635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr
Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser
Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr
Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val
Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys
His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu
Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr
Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 755
760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp
Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met
Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn
Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr Arg His Tyr Phe
Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr Gly Met Ser Ser
Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845 Ser Gly Ser Val
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850 855 860 Asp Gly
Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 865 870 875
880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile
885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe
Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly
Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys
Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met Ala Pro Thr Lys
Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala Tyr Phe Ser Asp
Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970 975 Ile Gly Pro
Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 980 985 990 Gly
Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 995
1000 1005 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg
Asn 1010 1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro
Thr Phe Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly
Tyr Ile Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln
Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser
Asn Glu Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val
Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110
Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115
1120 1125 Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr
Ser 1130 1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly
His Ile Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr
Gly Gln Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser
Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser
Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His
Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230
Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235
1240 1245 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His
Asn 1250 1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg
Leu His Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg
Met Glu Leu Met Gly 1280 1285 1290
Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 1295
1300 1305 Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr
Asn 1310 1315 1320 Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu
His Leu Gln 1325 1330 1335 Gly Arg Ser Asn Ala Trp Arg Pro Gln Val
Asn Asn Pro Lys Glu 1340 1345 1350 Trp Leu Gln Val Asp Phe Gln Lys
Thr Met Lys Val Thr Gly Val 1355 1360 1365 Thr Thr Gln Gly Val Lys
Ser Leu Leu Thr Ser Met Tyr Val Lys 1370 1375 1380 Glu Phe Leu Ile
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu 1385 1390 1395 Phe Phe
Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp 1400 1405 1410
Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 1415
1420 1425 Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile
Ala 1430 1435 1440 Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp
Leu Tyr Asp 1445 1450 1455 Lys Thr His Thr Cys Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly 1460 1465 1470 Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 1475 1480 1485 Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val 1490 1495 1500 Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 1505 1510 1515 Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 1520 1525 1530
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 1535
1540 1545 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 1550 1555 1560 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 1565 1570 1575 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg Asp 1580 1585 1590 Glu Leu Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly 1595 1600 1605 Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln 1610 1615 1620 Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 1625 1630 1635 Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 1640 1645 1650
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 1655
1660 1665 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly 1670 1675 1680 Lys Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 1685 1690 1695 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly 1700 1705 1710 Ser Gly Gly Gly Gly Ser Arg Lys
Arg Arg Lys Arg Ala Gln Val 1715 1720 1725 Gln Leu Gln Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly Ser 1730 1735 1740 Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Met Phe Ser Arg Tyr 1745 1750 1755 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 1760 1765 1770
Val Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 1775
1780 1785 Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys
Asn 1790 1795 1800 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala 1805 1810 1815 Val Tyr Tyr Cys Ala Arg Gly Ala Thr Tyr
Thr Ser Arg Ser Asp 1820 1825 1830 Val Pro Asp Gln Thr Ser Phe Asp
Tyr Trp Gly Gln Gly Thr Leu 1835 1840 1845 Val Thr Val Ser Ser Gly
Ser Ala Ser Ala Pro Lys Leu Glu Glu 1850 1855 1860 Gly Glu Phe Ser
Glu Ala Arg Val Ser Glu Leu Thr Gln Asp Pro 1865 1870 1875 Ala Val
Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln 1880 1885 1890
Gly Asp Ser Leu Arg Asn Phe Tyr Ala Ser Trp Tyr Gln Gln Lys 1895
1900 1905 Pro Gly Gln Ala Pro Thr Leu Val Ile Tyr Gly Leu Ser Lys
Arg 1910 1915 1920 Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Ser
Ser Gly Asn 1925 1930 1935 Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln
Ala Glu Asp Glu Ala 1940 1945 1950 Asp Tyr Tyr Cys Leu Leu Tyr Tyr
Gly Gly Gly Gln Gln Gly Val 1955 1960 1965 Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Arg Gln Pro Lys Ala 1970 1975 1980 Ala Pro Ser Val
Thr Leu Phe Pro Pro Ser Ser Ala Ala Gly Gly 1985 1990 1995 Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 2000 2005 2010
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 2015
2020 2025 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly 2030 2035 2040 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met 2045 2050 2055 Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp Val Ser 2060 2065 2070 His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly Val 2075 2080 2085 Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Tyr Asn 2090 2095 2100 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp 2105 2110 2115 Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 2120 2125 2130
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 2135
2140 2145 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu 2150 2155 2160 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe 2165 2170 2175 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro 2180 2185 2190 Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly 2195 2200 2205 Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp 2210 2215 2220 Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 2225 2230 2235 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 2240 2245 2250
<210> SEQ ID NO 150 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 150 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser 1 5 10 15 Gly Gly Gly Gly Ser 20 <210> SEQ ID NO
151 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 151 Ala
Leu Arg Pro Arg 1 5 <210> SEQ ID NO 152 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 152 Arg Arg Arg Arg 1 <210> SEQ
ID NO 153 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 153 Leu
Val Pro Arg Gly 1 5 <210> SEQ ID NO 154 <211> LENGTH:
12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 154 Leu Gln Gln Ser Arg Lys Val Gly
Asp Ser Pro Asn 1 5 10 <210> SEQ ID NO 155 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic peptide <400> SEQUENCE: 155 Glu Ala Ser Tyr Pro Gly
Lys 1 5 <210> SEQ ID NO 156 <211> LENGTH: 271
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
<400> SEQUENCE: 156 Ala Gln Val Gln Leu Gln Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly 1 5 10 15 Gly Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Met Phe Ser Arg 20 25 30 Tyr Ala Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 35 40 45 Val Ser Gly Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 50 55 60 Val Lys
Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85
90 95 Cys Ala Arg Gly Ala Thr Tyr Thr Ser Arg Ser Asp Val Pro Asp
Gln 100 105 110 Thr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu Gly
Glu Phe Ser Glu Ala 130 135 140 Arg Val Ser Glu Leu Thr Gln Asp Pro
Ala Val Ser Val Ala Leu Gly 145 150 155 160 Gln Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Asn Phe Tyr 165 170 175 Ala Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Ile 180 185 190 Tyr Gly
Leu Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala 195 200 205
Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 210
215 220 Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Gly
Gln 225 230 235 240 Gln Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val
Leu Arg Gln Pro 245 250 255 Lys Ala Ala Pro Ser Val Thr Leu Phe Pro
Pro Ser Ser Ala Ala 260 265 270 <210> SEQ ID NO 157
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 157 Val Val
Gly Gly Ala 1 5 <210> SEQ ID NO 158 <211> LENGTH: 5859
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 158 atgcaaatag agctctccac
ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60 accagaagat
actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120
ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac
180 acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct
tttcaacatc 240 gctaagccaa ggccaccctg gatgggtctg ctaggtccta
ccatccaggc tgaggtttat 300 gatacagtgg tcattacact taagaacatg
gcttcccatc ctgtcagtct tcatgctgtt 360 ggtgtatcct actggaaagc
ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420 gagaaagaag
atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480
aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat
540 gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt
atgtagagaa 600 gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat
ttatactact ttttgctgta 660 tttgatgaag ggaaaagttg gcactcagaa
acaaagaact ccttgatgca ggatagggat 720 gctgcatctg ctcgggcctg
gcctaaaatg cacacagtca atggttatgt aaacaggtct 780 ctgccaggtc
tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840
accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat
900 cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac
actcttgatg 960 gaccttggac agtttctact gttttgtcat atctcttccc
accaacatga tggcatggaa 1020 gcttatgtca aagtagacag ctgtccagag
gaaccccaac tacgaatgaa aaataatgaa 1080 gaagcggaag actatgatga
tgatcttact gattctgaaa tggatgtggt caggtttgat 1140 gatgacaact
ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200
tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc
1260 cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg
gattggtagg 1320 aagtacaaaa aagtccgatt tatggcatac acagatgaaa
cctttaagac tcgtgaagct 1380 attcagcatg aatcaggaat cttgggacct
ttactttatg gggaagttgg agacacactg 1440 ttgattatat ttaagaatca
agcaagcaga ccatataaca tctaccctca cggaatcact 1500 gatgtccgtc
ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560
ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca
1620 actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa
tatggagaga 1680 gatctagctt caggactcat tggccctctc ctcatctgct
acaaagaatc tgtagatcaa 1740 agaggaaacc agataatgtc agacaagagg
aatgtcatcc tgttttctgt atttgatgag 1800 aaccgaagct ggtacctcac
agagaatata caacgctttc tccccaatcc agctggagtg 1860 cagcttgagg
atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920
tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc
1980 attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt
caaacacaaa 2040 atggtctatg aagacacact caccctattc ccattctcag
gagaaactgt cttcatgtcg 2100 atggaaaacc caggtctatg gattctgggg
tgccacaact cagactttcg gaacagaggc 2160 atgaccgcct tactgaaggt
ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220 agttatgaag
atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280
ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt
2340 cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat
gaagaaggaa 2400 gattttgaca tttatgatga ggatgaaaat cagagccccc
gcagctttca aaagaaaaca 2460 cgacactatt ttattgctgc agtggagagg
ctctgggatt atgggatgag tagctcccca 2520 catgttctaa gaaacagggc
tcagagtggc agtgtccctc agttcaagaa agttgttttc 2580 caggaattta
ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat 2640
ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc
2700 agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta
tgaggaagat 2760 cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc
ctaatgaaac caaaacttac 2820 ttttggaaag tgcaacatca tatggcaccc
actaaagatg agtttgactg caaagcctgg 2880 gcttatttct ctgatgttga
cctggaaaaa gatgtgcact caggcctgat tggacccctt 2940 ctggtctgcc
acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa 3000
tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg
3060 gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt
taaagagaat 3120 tatcgcttcc atgcaatcaa tggctacata atggatacac
tacctggctt agtaatggct 3180 caggatcaaa ggattcgatg gtatctgctc
agcatgggca gcaatgaaaa catccattct 3240 attcatttca gtggacatgt
gttcactgta cgaaaaaaag aggagtataa aatggcactg 3300 tacaatctct
atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt 3360
tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg
3420 gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat
tagagatttt 3480 cagattacag cttcaggaca atatggacag tgggccccaa
agctggccag acttcattat 3540 tccggatcaa tcaatgcctg gagcaccaag
gagccctttt cttggatcaa ggtggatctg 3600 ttggcaccaa tgattattca
cggcatcaag acccagggtg cccgtcagaa gttctccagc 3660 ctctacatct
ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat 3720
cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata
3780 aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca
cccaactcat 3840 tatagcattc gcagcactct tcgcatggag ttgatgggct
gtgatttaaa tagttgcagc 3900 atgccattgg gaatggagag taaagcaata
tcagatgcac agattactgc ttcatcctac 3960 tttaccaata tgtttgccac
ctggtctcct tcaaaagctc gacttcacct ccaagggagg 4020 agtaatgcct
ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag 4080
aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg
4140 tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac
tctctttttt 4200 cagaatggca aagtaaaggt ttttcaggga aatcaagact
ccttcacacc tgtggtgaac 4260 tctctagacc caccgttact gactcgctac
cttcgaattc acccccagag ttgggtgcac 4320
cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta cgacaaaact
4380 cacacatgcc caccgtgccc agcacctgaa ctcctgggag gaccgtcagt
cttcctcttc 4440 cccccaaaac ccaaggacac cctcatgatc tcccggaccc
ctgaggtcac atgcgtggtg 4500 gtggacgtga gccacgaaga ccctgaggtc
aagttcaact ggtacgtgga cggcgtggag 4560 gtgcataatg ccaagacaaa
gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 4620 agcgtcctca
ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 4680
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc
4740 cgagaaccac aggtgtacac cctgccccca tcccgcgatg agctgaccaa
gaaccaggtc 4800 agcctgacct gcctggtcaa aggcttctat cccagcgaca
tcgccgtgga gtgggagagc 4860 aatgggcagc cggagaacaa ctacaagacc
acgcctcccg tgttggactc cgacggctcc 4920 ttcttcctct acagcaagct
caccgtcgac aagagcaggt ggcagcaggg gaacgtcttc 4980 tcatgctccg
tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 5040
tctccgggta aacggcgccg ccggagcggt ggcggcggat caggtggggg tggatcaggc
5100 ggtggaggtt ccggtggcgg gggatccggc ggtggaggtt ccggtggggg
tggatcaagg 5160 aagaggagga agagggacaa aactcacaca tgcccaccgt
gcccagctcc agaactcctg 5220 ggcggaccgt cagtcttcct cttcccccca
aaacccaagg acaccctcat gatctcccgg 5280 acccctgagg tcacatgcgt
ggtggtggac gtgagccacg aagaccctga ggtcaagttc 5340 aactggtacg
tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 5400
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat
5460 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat
cgagaaaacc 5520 atctccaaag ccaaagggca gccccgagaa ccacaggtgt
acaccctgcc cccatcccgg 5580 gatgagctga ccaagaacca ggtcagcctg
acctgcctgg tcaaaggctt ctatcccagc 5640 gacatcgccg tggagtggga
gagcaatggg cagccggaga acaactacaa gaccacgcct 5700 cccgtgttgg
actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 5760
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac
5820 tacacgcaga agagcctctc cctgtctccg ggtaaatga 5859 <210>
SEQ ID NO 159 <211> LENGTH: 1952 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct <400>
SEQUENCE: 159 Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu
Leu Arg Phe 1 5 10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly
Ala Val Glu Leu Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly
Glu Leu Pro Val Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys
Ser Phe Pro Phe Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu
Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro
Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala
Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105
110 His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser
115 120 125 Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys
Glu Asp 130 135 140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val
Trp Gln Val Leu 145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu
Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val
Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu
His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys
Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230
235 240 Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr 245 250 255 Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg
Lys Ser Val 260 265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro
Glu Val His Ser Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val
Arg Asn His Arg Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr
Phe Leu Thr Ala Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly
Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355
360 365 Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn
Ser 370 375 380 Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His
Pro Lys Thr 385 390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg
Ser Tyr Lys Ser Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile
Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp
Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly
Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475
480 Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro
485 490 495 His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu
Pro Lys 500 505 510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro
Gly Glu Ile Phe 515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp
Gly Pro Thr Lys Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr
Ser Ser Phe Val Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly
Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp
Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile
Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600
605 Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp
610 615 620 Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly
Tyr Val 625 630 635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His
Glu Val Ala Tyr Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr
Asp Phe Leu Ser Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His
Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser
Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725
730 735 Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser
Lys 740 745 750 Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro
Pro Val Leu 755 760 765 Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr
Leu Gln Ser Asp Gln 770 775 780 Glu Glu Ile Asp Tyr Asp Asp Thr Ile
Ser Val Glu Met Lys Lys Glu 785 790 795 800 Asp Phe Asp Ile Tyr Asp
Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 805 810 815 Gln Lys Lys Thr
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 820 825 830 Asp Tyr
Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840 845
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 850
855 860 Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu
His 865 870 875 880 Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val
Glu Asp Asn Ile 885 890 895 Met Val Thr Phe Arg Asn Gln Ala Ser Arg
Pro Tyr Ser Phe Tyr Ser 900 905 910 Ser Leu Ile Ser Tyr Glu Glu Asp
Gln Arg Gln Gly Ala Glu Pro Arg 915 920 925 Lys Asn Phe Val Lys Pro
Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 930 935 940 Gln His His Met
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 945 950 955 960 Ala
Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 965 970
975 Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His
980 985 990 Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr
Ile Phe 995 1000 1005
Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 1010
1015 1020 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe
Lys 1025 1030 1035 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile
Met Asp Thr 1040 1045 1050 Leu Pro Gly Leu Val Met Ala Gln Asp Gln
Arg Ile Arg Trp Tyr 1055 1060 1065 Leu Leu Ser Met Gly Ser Asn Glu
Asn Ile His Ser Ile His Phe 1070 1075 1080 Ser Gly His Val Phe Thr
Val Arg Lys Lys Glu Glu Tyr Lys Met 1085 1090 1095 Ala Leu Tyr Asn
Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1100 1105 1110 Leu Pro
Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1115 1120 1125
Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser 1130
1135 1140 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile
Arg 1145 1150 1155 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln
Trp Ala Pro 1160 1165 1170 Lys Leu Ala Arg Leu His Tyr Ser Gly Ser
Ile Asn Ala Trp Ser 1175 1180 1185 Thr Lys Glu Pro Phe Ser Trp Ile
Lys Val Asp Leu Leu Ala Pro 1190 1195 1200 Met Ile Ile His Gly Ile
Lys Thr Gln Gly Ala Arg Gln Lys Phe 1205 1210 1215 Ser Ser Leu Tyr
Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1220 1225 1230 Gly Lys
Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1235 1240 1245
Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn 1250
1255 1260 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His
Pro 1265 1270 1275 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu
Leu Met Gly 1280 1285 1290 Cys Asp Leu Asn Ser Cys Ser Met Pro Leu
Gly Met Glu Ser Lys 1295 1300 1305 Ala Ile Ser Asp Ala Gln Ile Thr
Ala Ser Ser Tyr Phe Thr Asn 1310 1315 1320 Met Phe Ala Thr Trp Ser
Pro Ser Lys Ala Arg Leu His Leu Gln 1325 1330 1335 Gly Arg Ser Asn
Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1340 1345 1350 Trp Leu
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1355 1360 1365
Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys 1370
1375 1380 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr
Leu 1385 1390 1395 Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly
Asn Gln Asp 1400 1405 1410 Ser Phe Thr Pro Val Val Asn Ser Leu Asp
Pro Pro Leu Leu Thr 1415 1420 1425 Arg Tyr Leu Arg Ile His Pro Gln
Ser Trp Val His Gln Ile Ala 1430 1435 1440 Leu Arg Met Glu Val Leu
Gly Cys Glu Ala Gln Asp Leu Tyr Asp 1445 1450 1455 Lys Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1460 1465 1470 Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 1475 1480 1485
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 1490
1495 1500 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly 1505 1510 1515 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Tyr 1520 1525 1530 Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln 1535 1540 1545 Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 1550 1555 1560 Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly 1565 1570 1575 Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 1580 1585 1590 Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 1595 1600 1605
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 1610
1615 1620 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp 1625 1630 1635 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg 1640 1645 1650 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala 1655 1660 1665 Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly 1670 1675 1680 Lys Arg Arg Arg Arg Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly 1685 1690 1695 Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1700 1705 1710 Ser Gly
Gly Gly Gly Ser Arg Lys Arg Arg Lys Arg Asp Lys Thr 1715 1720 1725
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 1730
1735 1740 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile 1745 1750 1755 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His 1760 1765 1770 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu 1775 1780 1785 Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser 1790 1795 1800 Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 1805 1810 1815 Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 1820 1825 1830 Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 1835 1840 1845
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 1850
1855 1860 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr 1865 1870 1875 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu 1880 1885 1890 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser 1895 1900 1905 Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln 1910 1915 1920 Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His 1925 1930 1935 Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 1940 1945 1950
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