U.S. patent application number 13/750378 was filed with the patent office on 2013-07-25 for production of secreted proteins by filamentous fungi. This patent application is currently assigned to DSM IP ASSETS B.V.. The applicant listed for this patent is WALRAVEN HENRY MULLER, NOEL NICOLAAS MARIA ELISABETH VAN PEIJ, CORNELIS MARIA JACOBUS SAGT, CORNELIS THEODORUS VERRIPS. Invention is credited to WALRAVEN HENRY MULLER, NOEL NICOLAAS MARIA ELISABETH VAN PEIJ, CORNELIS MARIA JACOBUS SAGT, CORNELIS THEODORUS VERRIPS.
Application Number | 20130189733 13/750378 |
Document ID | / |
Family ID | 39344638 |
Filed Date | 2013-07-25 |
United States Patent Application | 20130189733 |
Kind Code | A1 |
SAGT; CORNELIS MARIA JACOBUS ; et al. | July 25, 2013 |
The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
Inventors: | SAGT; CORNELIS MARIA JACOBUS; (UTRECHT, NL) ; VERRIPS; CORNELIS THEODORUS; (HOUTEN, NL) ; MULLER; WALRAVEN HENRY; (DORDRECHT, NL) ; PEIJ; NOEL NICOLAAS MARIA ELISABETH VAN; (DELFGAUW, NL) | ||||||||||
Applicant: |
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Assignee: | DSM IP ASSETS B.V. HEERLEN NL |
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Family ID: | 39344638 | ||||||||||
Appl. No.: | 13/750378 | ||||||||||
Filed: | January 25, 2013 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12444760 | Apr 30, 2009 | 8389269 | ||
PCT/EP2007/061765 | Oct 31, 2007 | |||
13750378 | ||||
Current U.S. Class: | 435/69.1 ; 435/189; 435/193; 435/194; 435/196; 435/200; 435/233; 435/254.11; 435/254.3; 435/254.4; 435/254.5; 435/254.6; 435/254.7; 435/254.8; 530/350; 536/23.1; 536/23.74 |
Current CPC Class: | C12N 15/80 20130101; C12N 9/0004 20130101; C12P 21/00 20130101; C07K 14/38 20130101; C12N 9/10 20130101; C12N 9/2405 20130101; C12N 9/12 20130101; C12N 9/90 20130101; C12N 9/16 20130101 |
Class at Publication: | 435/69.1 ; 530/350; 435/194; 435/193; 435/200; 435/189; 435/233; 435/196; 536/23.74; 536/23.1; 435/254.3; 435/254.8; 435/254.7; 435/254.4; 435/254.5; 435/254.6; 435/254.11 |
International Class: | C12P 21/00 20060101 C12P021/00; C12N 9/12 20060101 C12N009/12; C12N 9/10 20060101 C12N009/10; C12N 15/80 20060101 C12N015/80; C12N 9/00 20060101 C12N009/00; C12N 9/90 20060101 C12N009/90; C12N 9/16 20060101 C12N009/16; C07K 14/38 20060101 C07K014/38; C12N 9/24 20060101 C12N009/24 |
Date | Code | Application Number |
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Nov 2, 2006 | EP | 06123392.0 |
Sequence CWU 1
1
6311510DNAAspergillus niger 1ccacttggcc aggcctggcc cccccagctt
cccccgttat gacacggtgg cctgtgttcc 60tgtgacacgg gcaagcagac gtcctccaca
agctgtgtcg acctacatca ccgtcctccc 120ttgcagtgcg gttaagataa
ggctcatagt aaatcgattg atccacaatt aaagatcaat 180cacctgtcac
gcttgaaatg atggaagaag cattctctcc agtcgactcc ctcgccggct
240ccccgacgcc tgagttgcca ttgttgacag tgtccccggc ggacacgtcg
cttgatgact 300cgtcagtaca ggcaggggag accaaggcgg aagagaagaa
gcctgtgaag aagagaaagt 360catggggcca ggaattgcca gtcccgaaga
ctaacttgcc cccaaggtaa gacatctata 420tccataatag actatgtatg
tatgtacacg atgctaattc gacataaaag gaaacgggcc 480aagactgaag
atgagaaaga gcaacgtcgt atcgagcgcg ttcttcgcaa tcgtgcggca
540gcacaaacat cacgcgagcg caagaggctc gaaatggaga agttggaaaa
tgagaagatt 600cagatggaac agcaaaacca gttccttctg caacgactat
cccagatgga agctgagaac 660aatcgcttaa accaacaagt cgctcaacta
tctgctgagg tccggggctc ccgtggcaac 720actcccaagc ccggctcccc
cgtctcagct tctcctaccc taactcctac cctatttaaa 780caagaacgcg
acgaaatccc tcttgaacgg attcctttcc ccacaccctc tatcaccgac
840tactccccta ccttgaggcc ttccactctg gctgagtcct ccgacgtgac
acaacatcct 900gcagcggtgt tgtgcgacct gcagtgtccg tcgctggact
cgaaggagaa ggaagtgccc 960tctctctctt tgacgtcggc tcaaaccctg
aacctcacgc tgccgatgat cttgcagctc 1020ctctttctga cgatgacttc
caccgcctat tcaacgttga ttcacccgtt gggtcagatt 1080cttcagtcct
tgaagacggg ttcgcctttg acgttctcga cggaggagat ctatcagcat
1140ttccatttga ttctatggtt gatttcgacc ccgaatctgt tggcttcgaa
ggcatcgagc 1200cgccccacgg tcttccggat gagacttctc gccagacttc
tagcgtgcaa cccagccttg 1260gcgcgtccac ttcgcgatgc gacgggcagg
gcattgcagc tggctgttag cgagcagttt 1320cgccagggag atgcatcggc
tgtcgatggt aacggagtcc aatggagctg ggagtctttg 1380ttgaccttgg
cgtggacgat agacctactc gaacagccgg gacgacgcaa acgaatcttg
1440agcggtttga aatcagcgaa aactggacgg cgaagtaata ttggcaagtc
tcaaaggagt 1500acacggagtt 151021026DNAAspergillus
nigerCDS(1)..(1026) 2atg gaa gaa gca ttc tct cca gtc gac tcc ctc
gcc ggc tcc ccg acg 48Met Glu Glu Ala Phe Ser Pro Val Asp Ser Leu
Ala Gly Ser Pro Thr 1 5 10 15 cct gag ttg cca ttg ttg aca gtg tcc
ccg gcg gac acg tcg ctt gat 96Pro Glu Leu Pro Leu Leu Thr Val Ser
Pro Ala Asp Thr Ser Leu Asp 20 25 30 gac tcg tca gta cag gca ggg
gag acc aag gcg gaa gag aag aag cct 144Asp Ser Ser Val Gln Ala Gly
Glu Thr Lys Ala Glu Glu Lys Lys Pro 35 40 45 gtg aag aag aga aag
tca tgg ggc cag gaa ttg cca gtc ccg aag act 192Val Lys Lys Arg Lys
Ser Trp Gly Gln Glu Leu Pro Val Pro Lys Thr 50 55 60 aac ttg ccc
cca agg aaa cgg gcc aag act gaa gat gag aaa gag caa 240Asn Leu Pro
Pro Arg Lys Arg Ala Lys Thr Glu Asp Glu Lys Glu Gln 65 70 75 80 cgt
cgt atc gag cgc gtt ctt cgc aat cgt gcg gca gca caa aca tca 288Arg
Arg Ile Glu Arg Val Leu Arg Asn Arg Ala Ala Ala Gln Thr Ser 85 90
95 cgc gag cgc aag agg ctc gaa atg gag aag ttg gaa aat gag aag att
336Arg Glu Arg Lys Arg Leu Glu Met Glu Lys Leu Glu Asn Glu Lys Ile
100 105 110 cag atg gaa cag caa aac cag ttc ctt ctg caa cga cta tcc
cag atg 384Gln Met Glu Gln Gln Asn Gln Phe Leu Leu Gln Arg Leu Ser
Gln Met 115 120 125 gaa gct gag aac aat cgc tta aac caa caa gtc gct
caa cta tct gct 432Glu Ala Glu Asn Asn Arg Leu Asn Gln Gln Val Ala
Gln Leu Ser Ala 130 135 140 gag gtc cgg ggc tcc cgt ggc aac act ccc
aag ccc ggc tcc ccc gtc 480Glu Val Arg Gly Ser Arg Gly Asn Thr Pro
Lys Pro Gly Ser Pro Val 145 150 155 160 tca gct tct cct acc cta act
cct acc cta ttt aaa caa gaa cgc gac 528Ser Ala Ser Pro Thr Leu Thr
Pro Thr Leu Phe Lys Gln Glu Arg Asp 165 170 175 gaa atc cct ctt gaa
cgg att cct ttc ccc aca ccc tct atc acc gac 576Glu Ile Pro Leu Glu
Arg Ile Pro Phe Pro Thr Pro Ser Ile Thr Asp 180 185 190 tac tcc cct
acc ttg agg cct tcc act ctg gct gag tcc tcc gac gtg 624Tyr Ser Pro
Thr Leu Arg Pro Ser Thr Leu Ala Glu Ser Ser Asp Val 195 200 205 aca
caa cat cct gca gtg tcc gtc gct gga ctc gaa gga gaa gga agt 672Thr
Gln His Pro Ala Val Ser Val Ala Gly Leu Glu Gly Glu Gly Ser 210 215
220 gcc ctc tct ctc ttt gac gtc ggc tca aac cct gaa cct cac gct gcc
720Ala Leu Ser Leu Phe Asp Val Gly Ser Asn Pro Glu Pro His Ala Ala
225 230 235 240 gat gat ctt gca gct cct ctt tct gac gat gac ttc cac
cgc cta ttc 768Asp Asp Leu Ala Ala Pro Leu Ser Asp Asp Asp Phe His
Arg Leu Phe 245 250 255 aac gtt gat tca ccc gtt ggg tca gat tct tca
gtc ctt gaa gac ggg 816Asn Val Asp Ser Pro Val Gly Ser Asp Ser Ser
Val Leu Glu Asp Gly 260 265 270 ttc gcc ttt gac gtt ctc gac gga gga
gat cta tca gca ttt cca ttt 864Phe Ala Phe Asp Val Leu Asp Gly Gly
Asp Leu Ser Ala Phe Pro Phe 275 280 285 gat tct atg gtt gat ttc gac
ccc gaa tct gtt ggc ttc gaa ggc atc 912Asp Ser Met Val Asp Phe Asp
Pro Glu Ser Val Gly Phe Glu Gly Ile 290 295 300 gag ccg ccc cac ggt
ctt ccg gat gag act tct cgc cag act tct agc 960Glu Pro Pro His Gly
Leu Pro Asp Glu Thr Ser Arg Gln Thr Ser Ser 305 310 315 320 gtg caa
ccc agc ctt ggc gcg tcc act tcg cga tgc gac ggg cag ggc 1008Val Gln
Pro Ser Leu Gly Ala Ser Thr Ser Arg Cys Asp Gly Gln Gly 325 330 335
att gca gct ggc tgt tag 1026Ile Ala Ala Gly Cys 340
3341PRTAspergillus niger 3Met Glu Glu Ala Phe Ser Pro Val Asp Ser
Leu Ala Gly Ser Pro Thr 1 5 10 15 Pro Glu Leu Pro Leu Leu Thr Val
Ser Pro Ala Asp Thr Ser Leu Asp 20 25 30 Asp Ser Ser Val Gln Ala
Gly Glu Thr Lys Ala Glu Glu Lys Lys Pro 35 40 45 Val Lys Lys Arg
Lys Ser Trp Gly Gln Glu Leu Pro Val Pro Lys Thr 50 55 60 Asn Leu
Pro Pro Arg Lys Arg Ala Lys Thr Glu Asp Glu Lys Glu Gln 65 70 75 80
Arg Arg Ile Glu Arg Val Leu Arg Asn Arg Ala Ala Ala Gln Thr Ser 85
90 95 Arg Glu Arg Lys Arg Leu Glu Met Glu Lys Leu Glu Asn Glu Lys
Ile 100 105 110 Gln Met Glu Gln Gln Asn Gln Phe Leu Leu Gln Arg Leu
Ser Gln Met 115 120 125 Glu Ala Glu Asn Asn Arg Leu Asn Gln Gln Val
Ala Gln Leu Ser Ala 130 135 140 Glu Val Arg Gly Ser Arg Gly Asn Thr
Pro Lys Pro Gly Ser Pro Val 145 150 155 160 Ser Ala Ser Pro Thr Leu
Thr Pro Thr Leu Phe Lys Gln Glu Arg Asp 165 170 175 Glu Ile Pro Leu
Glu Arg Ile Pro Phe Pro Thr Pro Ser Ile Thr Asp 180 185 190 Tyr Ser
Pro Thr Leu Arg Pro Ser Thr Leu Ala Glu Ser Ser Asp Val 195 200 205
Thr Gln His Pro Ala Val Ser Val Ala Gly Leu Glu Gly Glu Gly Ser 210
215 220 Ala Leu Ser Leu Phe Asp Val Gly Ser Asn Pro Glu Pro His Ala
Ala 225 230 235 240 Asp Asp Leu Ala Ala Pro Leu Ser Asp Asp Asp Phe
His Arg Leu Phe 245 250 255 Asn Val Asp Ser Pro Val Gly Ser Asp Ser
Ser Val Leu Glu Asp Gly 260 265 270 Phe Ala Phe Asp Val Leu Asp Gly
Gly Asp Leu Ser Ala Phe Pro Phe 275 280 285 Asp Ser Met Val Asp Phe
Asp Pro Glu Ser Val Gly Phe Glu Gly Ile 290 295 300 Glu Pro Pro His
Gly Leu Pro Asp Glu Thr Ser Arg Gln Thr Ser Ser 305 310 315 320 Val
Gln Pro Ser Leu Gly Ala Ser Thr Ser Arg Cys Asp Gly Gln Gly 325 330
335 Ile Ala Ala Gly Cys 340 41921DNAAspergillus niger 4gccgccattc
caaatccata caattcaata ttacttctta agacatttcg cgtcacatgc 60caagagcttc
aggacacctt gcttctatct acttctttct gtcctctctt ctccctctct
120tcttcctcga ttcatccccg ctgggtgatg ctttagctgc tactcttgga
tcccctctcg 180catcttcctt acccgcaatc atgctgcagc ccagctctgc
gttgcttttc gtcacgtcgc 240ttctggcggc gttgcccgtc aacgccgatg
gattgtatac gaagaagtcc cccgtcttgc 300aggtcaacca gaagaactac
gaccagctca ttgcaaactc caatcacact tcggtaagta 360cagctgtgca
ggttattaca attgcctaca gacaagtcta ataagctctc ctagatcgta
420gagtaagcca tcgatcaccc tacccatcta cctcccacaa tcctaaacct
ccccgctctc 480cctctagatt ctacgctccc tggtgcggcc actgccagaa
cctaaagccc gcctacgaaa 540aagccgcaac taatctcgac ggcctggcca
aagtcgccgc cgtcaattgc gactatgacg 600acaacaaacc cttctgcggc
cgcatgggcg tccagggctt ccctaccctc aagatcgtca 660cccccggcaa
gaaacccggc aagccccgcg tggaagacta caagggcgca cgaagtgcca
720aagcgattgt cgaggcagtc gtcgaccgga ttcccaacca tgtgaagcgc
gcaacagaca 780aggaccttga cacttggctc gcgcaggatg aggaatcccc
caaggccatc ctcttcacgg 840agaaaggcac caccagccca ctcctccgcg
ccctggccat cgacttcctc ggctccatcc 900aagtcgctca agtccgcaac
aaggaaaccg aagccgtcga gaaattcggc atcaccgagt 960tcccaacctt
cgtcctactc ccaggaggcg gccaagaccc catcgtctac gacggcgaac
1020tgaagaagaa gcccatggtc gaattcctca gccaagccgc tgctcctaac
ccggatcctg 1080ctcccaaggg ctcgaccgcg ccccgcgata acaacaagaa
gaaatccacc gaaccttctc 1140cagactccaa gattgtctcg gacgaggcca
aacccgccag tgtgcccatt ccggctcccc 1200ccattggtac cctgcccact
gcggaagccc tcgaggctgc ttgtctgatg ccgaaatccg 1260gtacctgtgt
gctggctctc ctccctgaac cgagtgagcc ggacgcagag ctcccggctc
1320cggccaagga cgccctcctc agtctcgctg agatctcgca caagcacgca
gtccgtaaga 1380gcaagctctt cccgttctac agtgtcccgg ctatcaatag
cggagctaag accctccgcg 1440ctgggcttgg tctgcctgag gataactcgg
tggagatcgt tgctgtgaat ggacgccgtg 1500gctggtggcg ccggtatgac
tcggttgagg gcgcagagta cggccaggag cgtgtcgagg 1560cttggattga
tgcgatcagg ctgggtgagg gtgagaagca gaagttgcct gatggcgttg
1620tcgttgaaga ggtagttgag gagaaggtcg aagagaaggt cgaggaagtg
gttgaagaac 1680ccgtcgagga gaagccggcg gtcgaccacg acgaattgta
aaacatatgg tccgtatgga 1740gtgcatgaat ttgtttatta gcacaggtgt
ttatcaggtc aaataagtac tactagctgg 1800tttcccatat cgagtatcaa
aagcatacat atcatctact gtcagctact tcaattccac 1860taatcgggat
gaacttgtat tggaacactc atgtagaaat aagctctcta aagattcaat 1920t
192151395DNAAspergillus nigerCDS(1)..(1395) 5atg ctg cag ccc agc
tct gcg ttg ctt ttc gtc acg tcg ctt ctg gcg 48Met Leu Gln Pro Ser
Ser Ala Leu Leu Phe Val Thr Ser Leu Leu Ala 1 5 10 15 gcg ttg ccc
gtc aac gcc gat gga ttg tat acg aag aag tcc ccc gtc 96Ala Leu Pro
Val Asn Ala Asp Gly Leu Tyr Thr Lys Lys Ser Pro Val 20 25 30 ttg
cag gtc aac cag aag aac tac gac cag ctc att gca aac tcc aat 144Leu
Gln Val Asn Gln Lys Asn Tyr Asp Gln Leu Ile Ala Asn Ser Asn 35 40
45 cac act tcg atc gta gaa ttc tac gct ccc tgg tgc ggc cac tgc cag
192His Thr Ser Ile Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln
50 55 60 aac cta aag ccc gcc tac gaa aaa gcc gca act aat ctc gac
ggc ctg 240Asn Leu Lys Pro Ala Tyr Glu Lys Ala Ala Thr Asn Leu Asp
Gly Leu 65 70 75 80 gcc aaa gtc gcc gcc gtc aat tgc gac tat gac gac
aac aaa ccc ttc 288Ala Lys Val Ala Ala Val Asn Cys Asp Tyr Asp Asp
Asn Lys Pro Phe 85 90 95 tgc ggc cgc atg ggc gtc cag ggc ttc cct
acc ctc aag atc gtc acc 336Cys Gly Arg Met Gly Val Gln Gly Phe Pro
Thr Leu Lys Ile Val Thr 100 105 110 ccc ggc aag aaa ccc ggc aag ccc
cgc gtg gaa gac tac aag ggc gca 384Pro Gly Lys Lys Pro Gly Lys Pro
Arg Val Glu Asp Tyr Lys Gly Ala 115 120 125 cga agt gcc aaa gcg att
gtc gag gca gtc gtc gac cgg att ccc aac 432Arg Ser Ala Lys Ala Ile
Val Glu Ala Val Val Asp Arg Ile Pro Asn 130 135 140 cat gtg aag cgc
gca aca gac aag gac ctt gac act tgg ctc gcg cag 480His Val Lys Arg
Ala Thr Asp Lys Asp Leu Asp Thr Trp Leu Ala Gln 145 150 155 160 gat
gag gaa tcc ccc aag gcc atc ctc ttc acg gag aaa ggc acc acc 528Asp
Glu Glu Ser Pro Lys Ala Ile Leu Phe Thr Glu Lys Gly Thr Thr 165 170
175 agc cca ctc ctc cgc gcc ctg gcc atc gac ttc ctc ggc tcc atc caa
576Ser Pro Leu Leu Arg Ala Leu Ala Ile Asp Phe Leu Gly Ser Ile Gln
180 185 190 gtc gct caa gtc cgc aac aag gaa acc gaa gcc gtc gag aaa
ttc ggc 624Val Ala Gln Val Arg Asn Lys Glu Thr Glu Ala Val Glu Lys
Phe Gly 195 200 205 atc acc gag ttc cca acc ttc gtc cta ctc cca gga
ggc ggc caa gac 672Ile Thr Glu Phe Pro Thr Phe Val Leu Leu Pro Gly
Gly Gly Gln Asp 210 215 220 ccc atc gtc tac gac ggc gaa ctg aag aag
aag ccc atg gtc gaa ttc 720Pro Ile Val Tyr Asp Gly Glu Leu Lys Lys
Lys Pro Met Val Glu Phe 225 230 235 240 ctc agc caa gcc gct gct cct
aac ccg gat cct gct ccc aag ggc tcg 768Leu Ser Gln Ala Ala Ala Pro
Asn Pro Asp Pro Ala Pro Lys Gly Ser 245 250 255 acc gcg ccc cgc gat
aac aac aag aag aaa tcc acc gaa cct tct cca 816Thr Ala Pro Arg Asp
Asn Asn Lys Lys Lys Ser Thr Glu Pro Ser Pro 260 265 270 gac tcc aag
att gtc tcg gac gag gcc aaa ccc gcc agt gtg ccc att 864Asp Ser Lys
Ile Val Ser Asp Glu Ala Lys Pro Ala Ser Val Pro Ile 275 280 285 ccg
gct ccc ccc att ggt acc ctg ccc act gcg gaa gcc ctc gag gct 912Pro
Ala Pro Pro Ile Gly Thr Leu Pro Thr Ala Glu Ala Leu Glu Ala 290 295
300 gct tgt ctg atg ccg aaa tcc ggt acc tgt gtg ctg gct ctc ctc cct
960Ala Cys Leu Met Pro Lys Ser Gly Thr Cys Val Leu Ala Leu Leu Pro
305 310 315 320 gaa ccg agt gag ccg gac gca gag ctc ccg gct ccg gcc
aag gac gcc 1008Glu Pro Ser Glu Pro Asp Ala Glu Leu Pro Ala Pro Ala
Lys Asp Ala 325 330 335 ctc ctc agt ctc gct gag atc tcg cac aag cac
gca gtc cgt aag agc 1056Leu Leu Ser Leu Ala Glu Ile Ser His Lys His
Ala Val Arg Lys Ser 340 345 350 aag ctc ttc ccg ttc tac agt gtc ccg
gct atc aat agc gga gct aag 1104Lys Leu Phe Pro Phe Tyr Ser Val Pro
Ala Ile Asn Ser Gly Ala Lys 355 360 365 acc ctc cgc gct ggg ctt ggt
ctg cct gag gat aac tcg gtg gag atc 1152Thr Leu Arg Ala Gly Leu Gly
Leu Pro Glu Asp Asn Ser Val Glu Ile 370 375 380 gtt gct gtg aat gga
cgc cgt ggc tgg tgg cgc cgg tat gac tcg gtt 1200Val Ala Val Asn Gly
Arg Arg Gly Trp Trp Arg Arg Tyr Asp Ser Val 385 390 395 400 gag ggc
gca gag tac ggc cag gag cgt gtc gag gct tgg att gat gcg 1248Glu Gly
Ala Glu Tyr Gly Gln Glu Arg Val Glu Ala Trp Ile Asp Ala 405 410 415
atc agg ctg ggt gag ggt gag aag cag aag ttg cct gat ggc gtt gtc
1296Ile Arg Leu Gly Glu Gly Glu Lys Gln Lys Leu Pro Asp Gly Val Val
420 425 430 gtt gaa gag gta gtt gag gag aag gtc gaa gag aag gtc gag
gaa gtg 1344Val Glu Glu Val Val Glu Glu Lys Val Glu Glu Lys Val Glu
Glu Val 435 440 445 gtt gaa gaa ccc gtc gag gag aag ccg gcg gtc gac
cac gac gaa ttg 1392Val Glu Glu Pro Val Glu Glu Lys Pro Ala Val Asp
His Asp Glu Leu 450 455 460 taa 13956464PRTAspergillus niger 6Met
Leu Gln Pro Ser Ser Ala Leu Leu Phe Val Thr Ser Leu Leu Ala 1 5 10
15 Ala Leu Pro Val Asn Ala Asp Gly Leu Tyr Thr Lys Lys Ser Pro Val
20 25 30 Leu Gln Val Asn Gln Lys Asn Tyr Asp Gln Leu Ile Ala Asn
Ser Asn 35 40 45 His Thr Ser Ile Val Glu Phe Tyr Ala Pro Trp Cys
Gly His Cys Gln 50 55 60 Asn Leu Lys Pro Ala Tyr Glu Lys Ala Ala
Thr Asn Leu Asp Gly Leu 65 70 75 80 Ala Lys Val Ala Ala Val Asn Cys
Asp Tyr Asp Asp Asn Lys Pro Phe 85 90 95 Cys Gly Arg Met Gly Val
Gln Gly Phe Pro Thr Leu Lys Ile Val Thr 100 105 110 Pro Gly
Lys Lys Pro Gly Lys Pro Arg Val Glu Asp Tyr Lys Gly Ala 115 120 125
Arg Ser Ala Lys Ala Ile Val Glu Ala Val Val Asp Arg Ile Pro Asn 130
135 140 His Val Lys Arg Ala Thr Asp Lys Asp Leu Asp Thr Trp Leu Ala
Gln 145 150 155 160 Asp Glu Glu Ser Pro Lys Ala Ile Leu Phe Thr Glu
Lys Gly Thr Thr 165 170 175 Ser Pro Leu Leu Arg Ala Leu Ala Ile Asp
Phe Leu Gly Ser Ile Gln 180 185 190 Val Ala Gln Val Arg Asn Lys Glu
Thr Glu Ala Val Glu Lys Phe Gly 195 200 205 Ile Thr Glu Phe Pro Thr
Phe Val Leu Leu Pro Gly Gly Gly Gln Asp 210 215 220 Pro Ile Val Tyr
Asp Gly Glu Leu Lys Lys Lys Pro Met Val Glu Phe 225 230 235 240 Leu
Ser Gln Ala Ala Ala Pro Asn Pro Asp Pro Ala Pro Lys Gly Ser 245 250
255 Thr Ala Pro Arg Asp Asn Asn Lys Lys Lys Ser Thr Glu Pro Ser Pro
260 265 270 Asp Ser Lys Ile Val Ser Asp Glu Ala Lys Pro Ala Ser Val
Pro Ile 275 280 285 Pro Ala Pro Pro Ile Gly Thr Leu Pro Thr Ala Glu
Ala Leu Glu Ala 290 295 300 Ala Cys Leu Met Pro Lys Ser Gly Thr Cys
Val Leu Ala Leu Leu Pro 305 310 315 320 Glu Pro Ser Glu Pro Asp Ala
Glu Leu Pro Ala Pro Ala Lys Asp Ala 325 330 335 Leu Leu Ser Leu Ala
Glu Ile Ser His Lys His Ala Val Arg Lys Ser 340 345 350 Lys Leu Phe
Pro Phe Tyr Ser Val Pro Ala Ile Asn Ser Gly Ala Lys 355 360 365 Thr
Leu Arg Ala Gly Leu Gly Leu Pro Glu Asp Asn Ser Val Glu Ile 370 375
380 Val Ala Val Asn Gly Arg Arg Gly Trp Trp Arg Arg Tyr Asp Ser Val
385 390 395 400 Glu Gly Ala Glu Tyr Gly Gln Glu Arg Val Glu Ala Trp
Ile Asp Ala 405 410 415 Ile Arg Leu Gly Glu Gly Glu Lys Gln Lys Leu
Pro Asp Gly Val Val 420 425 430 Val Glu Glu Val Val Glu Glu Lys Val
Glu Glu Lys Val Glu Glu Val 435 440 445 Val Glu Glu Pro Val Glu Glu
Lys Pro Ala Val Asp His Asp Glu Leu 450 455 460 73891DNAAspergillus
niger 7atccaattca tccattctat tccatcctat tcatccgctc aatgctgccc
ttcaattgcc 60catctgctct cgattcttct tccttctctt ttggttcctc ccacgcggat
tttaccaact 120gatgacacgc cccgtgccat cggatccctc actctccagc
ttctctctcc atctggccca 180ctgtattgga gtccctcagc atgcggtggc
ggctgcctgg cgcccggtcg acccttcctg 240ccagtgtcgc actcctcctg
ctccccgttc ttgttgctcc gcagcagtgg catgaacatc 300aacatgagct
ctcctccacc gtttccgtcc ctctccgacc gactggtttc acctccggcg
360tcgatacccc tccctctttc gacgtgaaat ccaacgatgc gagcgcccta
gcaaccctgg 420ctctggccgg ctctggccgc gccgttcgag cccctcctgc
ccaagccagc agctctaccg 480ctggcctggc tccgcagctt cacgcgcggt
ccctgcagga ctgggaggtt gaggactttg 540tcctgctggc gaccgtcgac
ggttccattc acgcacgcga ccgcaagacc ggtgccgctc 600gttgggccct
cgaggtcccg agcagcccta tggtcgaaag cctctaccac cgagccaatc
660gctccagctt cgaccgtgcc caaccagagg acgactttat ctggatcgtc
gagccgagtc 720agggcggaag cctctacatc tacagctcgg ggccagaggc
aggcctccag aaattgggat 780tgactgtgaa ggaacttgtt gacgaaacgc
cttactcggg gactgacccg gccgttactt 840atacggcacg aaaggaaacg
acgctgtata ccatcgatgc tcgcaccgga aacattctgc 900gggtgtttag
ctctagaggt cccatttcgt caggtcagga atgtcgaaag gttgatggtc
960tggatgtgga tatggaagaa tgcgaatccc cttcgggtac tctagtcctt
ggtcgtgtcg 1020aatacacggt agccatccag aacaccgaaa ccggtgatcc
aatctgcact ctcaagtact 1080cggagtggac ggccaacaac cgggatatgg
acctccagag ccagtacctc cgcacgatgg 1140atcaaagcca tatttacagc
atgcatgatg gtgtagtctt aggcttcgat cattcacgga 1200tggaccggcc
acggtacacc cagcgattct cgagtccggt ggtccgcgtc ttcgatgttg
1260ctcgtccggt cagcgccgac tcatctaacg accctactcc acttattcta
ctctcgcagc 1320ctctacagcc tcctgacccc gactacggta cgcttgacga
tcgtgatgaa agagtattca 1380ttgattacac cgagggtggt ggttggtatg
ccatgtcgga ggccacctac ccgcttgtca 1440ccgggagagc caagatggct
caatgctacg aaaaagatta cctccgccat ggtcaacccc 1500taacaagtct
gaccccgagt cagcaacaag atgcactagc aggagtccat tctttgaacg
1560gcccacgcgt cgtccgccgt cacatcccca gcatttctgg cccctcgtca
gccgatatgt 1620ccaatgacac gcctcgggag ttgatctata gctcatcgga
cttggcactg cctccggctc 1680tacgccacag caccattata cggaagggct
gggacaatgc cattgatatt tttgtgacgc 1740tcttgcttct gtttttcggc
accttcatct ggttcaattc tcatcacatt caggagcttg 1800ctaagcagaa
gctggatctg aaaaatatca tggcctcgta cggacagccg cccatgtcta
1860ccccctcaac tccaatcgtg gaagcccctc atttgaaacg cgaggctagc
cctaatcgca 1920tggcgaatct gactgtcgac atgaatgttt caggagagca
gccgcagggt ggtgactcga 1980cgccaaggcc caagaaatcc cagaactctc
ttgcgcccga cacaactcca cgcgtacgca 2040tccgggaacc gtctcaaggc
ccagatggcg atgacgatgt ggacgagctc aatctacaag 2100acggtgaaaa
gcctaagaag aaggctcgcc gcggtcgtcg tggtggcaag aatcataggc
2160ggggcaagaa gcccaatagc gacagcgaat ccagggaccc ggccgatcgc
gttgttgatg 2220aagtgaacaa gcttcaacct cagcctcgct tggaacccga
tgtacagctg gcccggacgg 2280tgtcgcatga gatcatggaa atggatggcg
ttctccagat cggccgtctt agggtgttca 2340ctgacgtggt cctgggacac
ggcagccacg ggaccgtggt gtatcggggc tcgttcgatg 2400gacgcgacgt
ggctgtcaag cgcatgctgg tagaattcta tgatattgca tcccatgaag
2460tgggcctgtt gcaagaaagt gatgaccatg gcaatgtgat ccggtactac
tgccgagagc 2520aggctgctgg tttcctctac attgctttgg agctctgccc
ggcctctttg caggatgtgg 2580ttgaacgtcc atcagatttc ccgcagttag
tccagggcgg cttggacctg ccggacgttc 2640tgcgccagat tgtggcaggt
gttcgctatc ttcattctct taagattgtg caccgcgatc 2700tgaagccaca
gaacatcttg gtggcgatgc ctcgcgggcg tactggttca cgctccctgc
2760ggttgctgat ctcggatttc ggcttgtgta agaagctcga agacaaccag
agctccttcc 2820gcgcaactac ggcacatgcc gcgggtacct caggctggcg
agcccctgaa ttgctggtag 2880acgacgacat gagcccggct atgcagggta
gcgagtccca acacaccgaa tcatcagaac 2940cagctgtggt ggatcctcaa
accaaccggc gggctactcg agctatcgac atcttctctt 3000tgggctgcgt
cttttattac gttctgacgc gggggtgcca tccttttgac aagaatggca
3060agtttatgcg cgaggccaac attgtcaagg gcaaccacaa cctcgatgag
ctgcagcgtc 3120tgggcgacta tgcctacgag gctgaagatc taatccagtc
catgttgtcg cttgatcctc 3180gacgacggta agtcgatgct cattacgtgc
catgcatagt actaactttt ctagacccga 3240tgcgagcgct gtgttgacgc
acccgttctt ttggcctcca tctgaccgtc ttagcttcct 3300ctgcgatgtc
tcggatcact ttgaatttga accgcgggat cctccttcgg acgccctttt
3360gtgtctcgag tcggtcgctc cacgagtgat gggcccggac atggatttcc
tgcgactact 3420gccacgggac tttaaggata atctcggcaa gcagcgtaag
tacacgggat cgaagatgtt 3480agatttgctg cgagccctcc ggaacaagcg
caaccattac aacgacatgc cggagcatct 3540caaggcacac atcggcgggt
tgcccgaggg gtatcttaat ttttggactg tgcgattccc 3600cagtcttctc
atgagctgcc actccgtcat tgtggagttg cgtttgacgc ggtccgaccg
3660tttcaagcgc tacttcacgg cgactgacta ggtggtgttc acccacgtag
acagtcattt 3720acttgtatac atgcatatct agatgacata tgtcacaatc
aataagttat acgagtctta 3780cttatcattc tatcaatggg aattcatgct
gcagagtcgt ccggtagtgt gggcggggta 3840gtcacgtgtc tagtctagtg
accggggaag ccctcagcga tgagtcatgg a 389183444DNAAspergillus
nigerCDS(1)..(3444) 8atg cgg tgg cgg ctg cct ggc gcc cgg tcg acc
ctt cct gcc agt gtc 48Met Arg Trp Arg Leu Pro Gly Ala Arg Ser Thr
Leu Pro Ala Ser Val 1 5 10 15 gca ctc ctc ctg ctc ccc gtt ctt gtt
gct ccg cag cag tgg cat gaa 96Ala Leu Leu Leu Leu Pro Val Leu Val
Ala Pro Gln Gln Trp His Glu 20 25 30 cat caa cat gag ctc tcc tcc
acc gtt tcc gtc cct ctc cga ccg act 144His Gln His Glu Leu Ser Ser
Thr Val Ser Val Pro Leu Arg Pro Thr 35 40 45 ggt ttc acc tcc ggc
gtc gat acc cct ccc tct ttc gac gtg aaa tcc 192Gly Phe Thr Ser Gly
Val Asp Thr Pro Pro Ser Phe Asp Val Lys Ser 50 55 60 aac gat gcg
agc gcc cta gca acc ctg gct ctg gcc ggc tct ggc cgc 240Asn Asp Ala
Ser Ala Leu Ala Thr Leu Ala Leu Ala Gly Ser Gly Arg 65 70 75 80 gcc
gtt cga gcc cct cct gcc caa gcc agc agc tct acc gct ggc ctg 288Ala
Val Arg Ala Pro Pro Ala Gln Ala Ser Ser Ser Thr Ala Gly Leu 85 90
95 gct ccg cag ctt cac gcg cgg tcc ctg cag gac tgg gag gtt gag gac
336Ala Pro Gln Leu His Ala Arg Ser Leu Gln Asp Trp Glu Val Glu Asp
100 105 110 ttt gtc ctg ctg gcg acc gtc gac ggt tcc att cac gca cgc
gac cgc 384Phe Val Leu Leu Ala Thr Val Asp Gly Ser Ile His Ala Arg
Asp Arg 115 120 125 aag acc ggt gcc gct cgt tgg gcc ctc gag gtc ccg
agc agc cct atg 432Lys Thr Gly Ala Ala Arg Trp Ala Leu Glu Val Pro
Ser Ser Pro Met 130 135 140 gtc gaa agc ctc tac cac cga gcc aat cgc
tcc agc ttc gac cgt gcc 480Val Glu Ser Leu Tyr His Arg Ala Asn Arg
Ser Ser Phe Asp Arg Ala 145 150 155 160 caa cca gag gac gac ttt atc
tgg atc gtc gag ccg agt cag ggc gga 528Gln Pro Glu Asp Asp Phe Ile
Trp Ile Val Glu Pro Ser Gln Gly Gly 165 170 175 agc ctc tac atc tac
agc tcg ggg cca gag gca ggc ctc cag aaa ttg 576Ser Leu Tyr Ile Tyr
Ser Ser Gly Pro Glu Ala Gly Leu Gln Lys Leu 180 185 190 gga ttg act
gtg aag gaa ctt gtt gac gaa acg cct tac tcg ggg act 624Gly Leu Thr
Val Lys Glu Leu Val Asp Glu Thr Pro Tyr Ser Gly Thr 195 200 205 gac
ccg gcc gtt act tat acg gca cga aag gaa acg acg ctg tat acc 672Asp
Pro Ala Val Thr Tyr Thr Ala Arg Lys Glu Thr Thr Leu Tyr Thr 210 215
220 atc gat gct cgc acc gga aac att ctg cgg gtg ttt agc tct aga ggt
720Ile Asp Ala Arg Thr Gly Asn Ile Leu Arg Val Phe Ser Ser Arg Gly
225 230 235 240 ccc att tcg tca ggt cag gaa tgt cga aag gtt gat ggt
ctg gat gtg 768Pro Ile Ser Ser Gly Gln Glu Cys Arg Lys Val Asp Gly
Leu Asp Val 245 250 255 gat atg gaa gaa tgc gaa tcc cct tcg ggt act
cta gtc ctt ggt cgt 816Asp Met Glu Glu Cys Glu Ser Pro Ser Gly Thr
Leu Val Leu Gly Arg 260 265 270 gtc gaa tac acg gta gcc atc cag aac
acc gaa acc ggt gat cca atc 864Val Glu Tyr Thr Val Ala Ile Gln Asn
Thr Glu Thr Gly Asp Pro Ile 275 280 285 tgc act ctc aag tac tcg gag
tgg acg gcc aac aac cgg gat atg gac 912Cys Thr Leu Lys Tyr Ser Glu
Trp Thr Ala Asn Asn Arg Asp Met Asp 290 295 300 ctc cag agc cag tac
ctc cgc acg atg gat caa agc cat att tac agc 960Leu Gln Ser Gln Tyr
Leu Arg Thr Met Asp Gln Ser His Ile Tyr Ser 305 310 315 320 atg cat
gat ggt gta gtc tta ggc ttc gat cat tca cgg atg gac cgg 1008Met His
Asp Gly Val Val Leu Gly Phe Asp His Ser Arg Met Asp Arg 325 330 335
cca cgg tac acc cag cga ttc tcg agt ccg gtg gtc cgc gtc ttc gat
1056Pro Arg Tyr Thr Gln Arg Phe Ser Ser Pro Val Val Arg Val Phe Asp
340 345 350 gtt gct cgt ccg gtc agc gcc gac tca tct aac gac cct act
cca ctt 1104Val Ala Arg Pro Val Ser Ala Asp Ser Ser Asn Asp Pro Thr
Pro Leu 355 360 365 att cta ctc tcg cag cct cta cag cct cct gac ccc
gac tac ggt acg 1152Ile Leu Leu Ser Gln Pro Leu Gln Pro Pro Asp Pro
Asp Tyr Gly Thr 370 375 380 ctt gac gat cgt gat gaa aga gta ttc att
gat tac acc gag ggt ggt 1200Leu Asp Asp Arg Asp Glu Arg Val Phe Ile
Asp Tyr Thr Glu Gly Gly 385 390 395 400 ggt tgg tat gcc atg tcg gag
gcc acc tac ccg ctt gtc acc ggg aga 1248Gly Trp Tyr Ala Met Ser Glu
Ala Thr Tyr Pro Leu Val Thr Gly Arg 405 410 415 gcc aag atg gct caa
tgc tac gaa aaa gat tac ctc cgc cat ggt caa 1296Ala Lys Met Ala Gln
Cys Tyr Glu Lys Asp Tyr Leu Arg His Gly Gln 420 425 430 ccc cta aca
agt ctg acc ccg agt cag caa caa gat gca cta gca gga 1344Pro Leu Thr
Ser Leu Thr Pro Ser Gln Gln Gln Asp Ala Leu Ala Gly 435 440 445 gtc
cat tct ttg aac ggc cca cgc gtc gtc cgc cgt cac atc ccc agc 1392Val
His Ser Leu Asn Gly Pro Arg Val Val Arg Arg His Ile Pro Ser 450 455
460 att tct ggc ccc tcg tca gcc gat atg tcc aat gac acg cct cgg gag
1440Ile Ser Gly Pro Ser Ser Ala Asp Met Ser Asn Asp Thr Pro Arg Glu
465 470 475 480 ttg atc tat agc tca tcg gac ttg gca ctg cct ccg gct
cta cgc cac 1488Leu Ile Tyr Ser Ser Ser Asp Leu Ala Leu Pro Pro Ala
Leu Arg His 485 490 495 agc acc att ata cgg aag ggc tgg gac aat gcc
att gat att ttt gtg 1536Ser Thr Ile Ile Arg Lys Gly Trp Asp Asn Ala
Ile Asp Ile Phe Val 500 505 510 acg ctc ttg ctt ctg ttt ttc ggc acc
ttc atc tgg ttc aat tct cat 1584Thr Leu Leu Leu Leu Phe Phe Gly Thr
Phe Ile Trp Phe Asn Ser His 515 520 525 cac att cag gag ctt gct aag
cag aag ctg gat ctg aaa aat atc atg 1632His Ile Gln Glu Leu Ala Lys
Gln Lys Leu Asp Leu Lys Asn Ile Met 530 535 540 gcc tcg tac gga cag
ccg ccc atg tct acc ccc tca act cca atc gtg 1680Ala Ser Tyr Gly Gln
Pro Pro Met Ser Thr Pro Ser Thr Pro Ile Val 545 550 555 560 gaa gcc
cct cat ttg aaa cgc gag gct agc cct aat cgc atg gcg aat 1728Glu Ala
Pro His Leu Lys Arg Glu Ala Ser Pro Asn Arg Met Ala Asn 565 570 575
ctg act gtc gac atg aat gtt tca gga gag cag ccg cag ggt ggt gac
1776Leu Thr Val Asp Met Asn Val Ser Gly Glu Gln Pro Gln Gly Gly Asp
580 585 590 tcg acg cca agg ccc aag aaa tcc cag aac tct ctt gcg ccc
gac aca 1824Ser Thr Pro Arg Pro Lys Lys Ser Gln Asn Ser Leu Ala Pro
Asp Thr 595 600 605 act cca cgc gta cgc atc cgg gaa ccg tct caa ggc
cca gat ggc gat 1872Thr Pro Arg Val Arg Ile Arg Glu Pro Ser Gln Gly
Pro Asp Gly Asp 610 615 620 gac gat gtg gac gag ctc aat cta caa gac
ggt gaa aag cct aag aag 1920Asp Asp Val Asp Glu Leu Asn Leu Gln Asp
Gly Glu Lys Pro Lys Lys 625 630 635 640 aag gct cgc cgc ggt cgt cgt
ggt ggc aag aat cat agg cgg ggc aag 1968Lys Ala Arg Arg Gly Arg Arg
Gly Gly Lys Asn His Arg Arg Gly Lys 645 650 655 aag ccc aat agc gac
agc gaa tcc agg gac ccg gcc gat cgc gtt gtt 2016Lys Pro Asn Ser Asp
Ser Glu Ser Arg Asp Pro Ala Asp Arg Val Val 660 665 670 gat gaa gtg
aac aag ctt caa cct cag cct cgc ttg gaa ccc gat gta 2064Asp Glu Val
Asn Lys Leu Gln Pro Gln Pro Arg Leu Glu Pro Asp Val 675 680 685 cag
ctg gcc cgg acg gtg tcg cat gag atc atg gaa atg gat ggc gtt 2112Gln
Leu Ala Arg Thr Val Ser His Glu Ile Met Glu Met Asp Gly Val 690 695
700 ctc cag atc ggc cgt ctt agg gtg ttc act gac gtg gtc ctg gga cac
2160Leu Gln Ile Gly Arg Leu Arg Val Phe Thr Asp Val Val Leu Gly His
705 710 715 720 ggc agc cac ggg acc gtg gtg tat cgg ggc tcg ttc gat
gga cgc gac 2208Gly Ser His Gly Thr Val Val Tyr Arg Gly Ser Phe Asp
Gly Arg Asp 725 730 735 gtg gct gtc aag cgc atg ctg gta gaa ttc tat
gat att gca tcc cat 2256Val Ala Val Lys Arg Met Leu Val Glu Phe Tyr
Asp Ile Ala Ser His 740 745 750 gaa gtg ggc ctg ttg caa gaa agt gat
gac cat ggc aat gtg atc cgg 2304Glu Val Gly Leu Leu Gln Glu Ser Asp
Asp His Gly Asn Val Ile Arg 755 760 765 tac tac tgc cga gag cag gct
gct ggt ttc ctc tac att gct ttg gag 2352Tyr Tyr Cys Arg Glu Gln Ala
Ala Gly Phe Leu Tyr Ile Ala Leu Glu 770 775 780 ctc tgc ccg gcc tct
ttg cag gat gtg gtt gaa cgt cca tca gat ttc 2400Leu Cys Pro Ala Ser
Leu Gln Asp Val Val Glu Arg Pro Ser Asp Phe 785 790 795 800 ccg cag
tta gtc cag ggc ggc ttg gac ctg ccg gac gtt ctg cgc cag 2448Pro Gln
Leu Val Gln Gly Gly Leu Asp Leu Pro Asp Val Leu Arg Gln 805 810 815
att gtg gca ggt gtt cgc tat ctt cat tct ctt aag att gtg cac cgc
2496Ile Val Ala Gly Val Arg Tyr Leu His Ser Leu Lys Ile Val His Arg
820 825 830 gat ctg aag cca cag aac atc ttg gtg gcg atg cct cgc ggg
cgt act 2544Asp Leu Lys Pro Gln Asn Ile Leu Val Ala Met Pro Arg Gly
Arg Thr 835 840 845 ggt tca cgc tcc ctg cgg ttg ctg atc tcg gat ttc
ggc ttg tgt aag
2592Gly Ser Arg Ser Leu Arg Leu Leu Ile Ser Asp Phe Gly Leu Cys Lys
850 855 860 aag ctc gaa gac aac cag agc tcc ttc cgc gca act acg gca
cat gcc 2640Lys Leu Glu Asp Asn Gln Ser Ser Phe Arg Ala Thr Thr Ala
His Ala 865 870 875 880 gcg ggt acc tca ggc tgg cga gcc cct gaa ttg
ctg gta gac gac gac 2688Ala Gly Thr Ser Gly Trp Arg Ala Pro Glu Leu
Leu Val Asp Asp Asp 885 890 895 atg agc ccg gct atg cag ggt agc gag
tcc caa cac acc gaa tca tca 2736Met Ser Pro Ala Met Gln Gly Ser Glu
Ser Gln His Thr Glu Ser Ser 900 905 910 gaa cca gct gtg gtg gat cct
caa acc aac cgg cgg gct act cga gct 2784Glu Pro Ala Val Val Asp Pro
Gln Thr Asn Arg Arg Ala Thr Arg Ala 915 920 925 atc gac atc ttc tct
ttg ggc tgc gtc ttt tat tac gtt ctg acg cgg 2832Ile Asp Ile Phe Ser
Leu Gly Cys Val Phe Tyr Tyr Val Leu Thr Arg 930 935 940 ggg tgc cat
cct ttt gac aag aat ggc aag ttt atg cgc gag gcc aac 2880Gly Cys His
Pro Phe Asp Lys Asn Gly Lys Phe Met Arg Glu Ala Asn 945 950 955 960
att gtc aag ggc aac cac aac ctc gat gag ctg cag cgt ctg ggc gac
2928Ile Val Lys Gly Asn His Asn Leu Asp Glu Leu Gln Arg Leu Gly Asp
965 970 975 tat gcc tac gag gct gaa gat cta atc cag tcc atg ttg tcg
ctt gat 2976Tyr Ala Tyr Glu Ala Glu Asp Leu Ile Gln Ser Met Leu Ser
Leu Asp 980 985 990 cct cga cga cga ccc gat gcg agc gct gtg ttg acg
cac ccg ttc ttt 3024Pro Arg Arg Arg Pro Asp Ala Ser Ala Val Leu Thr
His Pro Phe Phe 995 1000 1005 tgg cct cca tct gac cgt ctt agc ttc
ctc tgc gat gtc tcg gat cac 3072Trp Pro Pro Ser Asp Arg Leu Ser Phe
Leu Cys Asp Val Ser Asp His 1010 1015 1020 ttt gaa ttt gaa ccg cgg
gat cct cct tcg gac gcc ctt ttg tgt ctc 3120Phe Glu Phe Glu Pro Arg
Asp Pro Pro Ser Asp Ala Leu Leu Cys Leu 1025 1030 1035 1040gag tcg
gtc gct cca cga gtg atg ggc ccg gac atg gat ttc ctg cga 3168Glu Ser
Val Ala Pro Arg Val Met Gly Pro Asp Met Asp Phe Leu Arg 1045 1050
1055 cta ctg cca cgg gac ttt aag gat aat ctc ggc aag cag cgt aag
tac 3216Leu Leu Pro Arg Asp Phe Lys Asp Asn Leu Gly Lys Gln Arg Lys
Tyr 1060 1065 1070 acg gga tcg aag atg tta gat ttg ctg cga gcc ctc
cgg aac aag cgc 3264Thr Gly Ser Lys Met Leu Asp Leu Leu Arg Ala Leu
Arg Asn Lys Arg 1075 1080 1085 aac cat tac aac gac atg ccg gag cat
ctc aag gca cac atc ggc ggg 3312Asn His Tyr Asn Asp Met Pro Glu His
Leu Lys Ala His Ile Gly Gly 1090 1095 1100 ttg ccc gag ggg tat ctt
aat ttt tgg act gtg cga ttc ccc agt ctt 3360Leu Pro Glu Gly Tyr Leu
Asn Phe Trp Thr Val Arg Phe Pro Ser Leu 1105 1110 1115 1120ctc atg
agc tgc cac tcc gtc att gtg gag ttg cgt ttg acg cgg tcc 3408Leu Met
Ser Cys His Ser Val Ile Val Glu Leu Arg Leu Thr Arg Ser 1125 1130
1135 gac cgt ttc aag cgc tac ttc acg gcg act gac tag 3444Asp Arg
Phe Lys Arg Tyr Phe Thr Ala Thr Asp 1140 1145 91147PRTAspergillus
niger 9Met Arg Trp Arg Leu Pro Gly Ala Arg Ser Thr Leu Pro Ala Ser
Val 1 5 10 15 Ala Leu Leu Leu Leu Pro Val Leu Val Ala Pro Gln Gln
Trp His Glu 20 25 30 His Gln His Glu Leu Ser Ser Thr Val Ser Val
Pro Leu Arg Pro Thr 35 40 45 Gly Phe Thr Ser Gly Val Asp Thr Pro
Pro Ser Phe Asp Val Lys Ser 50 55 60 Asn Asp Ala Ser Ala Leu Ala
Thr Leu Ala Leu Ala Gly Ser Gly Arg 65 70 75 80 Ala Val Arg Ala Pro
Pro Ala Gln Ala Ser Ser Ser Thr Ala Gly Leu 85 90 95 Ala Pro Gln
Leu His Ala Arg Ser Leu Gln Asp Trp Glu Val Glu Asp 100 105 110 Phe
Val Leu Leu Ala Thr Val Asp Gly Ser Ile His Ala Arg Asp Arg 115 120
125 Lys Thr Gly Ala Ala Arg Trp Ala Leu Glu Val Pro Ser Ser Pro Met
130 135 140 Val Glu Ser Leu Tyr His Arg Ala Asn Arg Ser Ser Phe Asp
Arg Ala 145 150 155 160 Gln Pro Glu Asp Asp Phe Ile Trp Ile Val Glu
Pro Ser Gln Gly Gly 165 170 175 Ser Leu Tyr Ile Tyr Ser Ser Gly Pro
Glu Ala Gly Leu Gln Lys Leu 180 185 190 Gly Leu Thr Val Lys Glu Leu
Val Asp Glu Thr Pro Tyr Ser Gly Thr 195 200 205 Asp Pro Ala Val Thr
Tyr Thr Ala Arg Lys Glu Thr Thr Leu Tyr Thr 210 215 220 Ile Asp Ala
Arg Thr Gly Asn Ile Leu Arg Val Phe Ser Ser Arg Gly 225 230 235 240
Pro Ile Ser Ser Gly Gln Glu Cys Arg Lys Val Asp Gly Leu Asp Val 245
250 255 Asp Met Glu Glu Cys Glu Ser Pro Ser Gly Thr Leu Val Leu Gly
Arg 260 265 270 Val Glu Tyr Thr Val Ala Ile Gln Asn Thr Glu Thr Gly
Asp Pro Ile 275 280 285 Cys Thr Leu Lys Tyr Ser Glu Trp Thr Ala Asn
Asn Arg Asp Met Asp 290 295 300 Leu Gln Ser Gln Tyr Leu Arg Thr Met
Asp Gln Ser His Ile Tyr Ser 305 310 315 320 Met His Asp Gly Val Val
Leu Gly Phe Asp His Ser Arg Met Asp Arg 325 330 335 Pro Arg Tyr Thr
Gln Arg Phe Ser Ser Pro Val Val Arg Val Phe Asp 340 345 350 Val Ala
Arg Pro Val Ser Ala Asp Ser Ser Asn Asp Pro Thr Pro Leu 355 360 365
Ile Leu Leu Ser Gln Pro Leu Gln Pro Pro Asp Pro Asp Tyr Gly Thr 370
375 380 Leu Asp Asp Arg Asp Glu Arg Val Phe Ile Asp Tyr Thr Glu Gly
Gly 385 390 395 400 Gly Trp Tyr Ala Met Ser Glu Ala Thr Tyr Pro Leu
Val Thr Gly Arg 405 410 415 Ala Lys Met Ala Gln Cys Tyr Glu Lys Asp
Tyr Leu Arg His Gly Gln 420 425 430 Pro Leu Thr Ser Leu Thr Pro Ser
Gln Gln Gln Asp Ala Leu Ala Gly 435 440 445 Val His Ser Leu Asn Gly
Pro Arg Val Val Arg Arg His Ile Pro Ser 450 455 460 Ile Ser Gly Pro
Ser Ser Ala Asp Met Ser Asn Asp Thr Pro Arg Glu 465 470 475 480 Leu
Ile Tyr Ser Ser Ser Asp Leu Ala Leu Pro Pro Ala Leu Arg His 485 490
495 Ser Thr Ile Ile Arg Lys Gly Trp Asp Asn Ala Ile Asp Ile Phe Val
500 505 510 Thr Leu Leu Leu Leu Phe Phe Gly Thr Phe Ile Trp Phe Asn
Ser His 515 520 525 His Ile Gln Glu Leu Ala Lys Gln Lys Leu Asp Leu
Lys Asn Ile Met 530 535 540 Ala Ser Tyr Gly Gln Pro Pro Met Ser Thr
Pro Ser Thr Pro Ile Val 545 550 555 560 Glu Ala Pro His Leu Lys Arg
Glu Ala Ser Pro Asn Arg Met Ala Asn 565 570 575 Leu Thr Val Asp Met
Asn Val Ser Gly Glu Gln Pro Gln Gly Gly Asp 580 585 590 Ser Thr Pro
Arg Pro Lys Lys Ser Gln Asn Ser Leu Ala Pro Asp Thr 595 600 605 Thr
Pro Arg Val Arg Ile Arg Glu Pro Ser Gln Gly Pro Asp Gly Asp 610 615
620 Asp Asp Val Asp Glu Leu Asn Leu Gln Asp Gly Glu Lys Pro Lys Lys
625 630 635 640 Lys Ala Arg Arg Gly Arg Arg Gly Gly Lys Asn His Arg
Arg Gly Lys 645 650 655 Lys Pro Asn Ser Asp Ser Glu Ser Arg Asp Pro
Ala Asp Arg Val Val 660 665 670 Asp Glu Val Asn Lys Leu Gln Pro Gln
Pro Arg Leu Glu Pro Asp Val 675 680 685 Gln Leu Ala Arg Thr Val Ser
His Glu Ile Met Glu Met Asp Gly Val 690 695 700 Leu Gln Ile Gly Arg
Leu Arg Val Phe Thr Asp Val Val Leu Gly His 705 710 715 720 Gly Ser
His Gly Thr Val Val Tyr Arg Gly Ser Phe Asp Gly Arg Asp 725 730 735
Val Ala Val Lys Arg Met Leu Val Glu Phe Tyr Asp Ile Ala Ser His 740
745 750 Glu Val Gly Leu Leu Gln Glu Ser Asp Asp His Gly Asn Val Ile
Arg 755 760 765 Tyr Tyr Cys Arg Glu Gln Ala Ala Gly Phe Leu Tyr Ile
Ala Leu Glu 770 775 780 Leu Cys Pro Ala Ser Leu Gln Asp Val Val Glu
Arg Pro Ser Asp Phe 785 790 795 800 Pro Gln Leu Val Gln Gly Gly Leu
Asp Leu Pro Asp Val Leu Arg Gln 805 810 815 Ile Val Ala Gly Val Arg
Tyr Leu His Ser Leu Lys Ile Val His Arg 820 825 830 Asp Leu Lys Pro
Gln Asn Ile Leu Val Ala Met Pro Arg Gly Arg Thr 835 840 845 Gly Ser
Arg Ser Leu Arg Leu Leu Ile Ser Asp Phe Gly Leu Cys Lys 850 855 860
Lys Leu Glu Asp Asn Gln Ser Ser Phe Arg Ala Thr Thr Ala His Ala 865
870 875 880 Ala Gly Thr Ser Gly Trp Arg Ala Pro Glu Leu Leu Val Asp
Asp Asp 885 890 895 Met Ser Pro Ala Met Gln Gly Ser Glu Ser Gln His
Thr Glu Ser Ser 900 905 910 Glu Pro Ala Val Val Asp Pro Gln Thr Asn
Arg Arg Ala Thr Arg Ala 915 920 925 Ile Asp Ile Phe Ser Leu Gly Cys
Val Phe Tyr Tyr Val Leu Thr Arg 930 935 940 Gly Cys His Pro Phe Asp
Lys Asn Gly Lys Phe Met Arg Glu Ala Asn 945 950 955 960 Ile Val Lys
Gly Asn His Asn Leu Asp Glu Leu Gln Arg Leu Gly Asp 965 970 975 Tyr
Ala Tyr Glu Ala Glu Asp Leu Ile Gln Ser Met Leu Ser Leu Asp 980 985
990 Pro Arg Arg Arg Pro Asp Ala Ser Ala Val Leu Thr His Pro Phe Phe
995 1000 1005 Trp Pro Pro Ser Asp Arg Leu Ser Phe Leu Cys Asp Val
Ser Asp His 1010 1015 1020 Phe Glu Phe Glu Pro Arg Asp Pro Pro Ser
Asp Ala Leu Leu Cys Leu 1025 1030 1035 1040Glu Ser Val Ala Pro Arg
Val Met Gly Pro Asp Met Asp Phe Leu Arg 1045 1050 1055 Leu Leu Pro
Arg Asp Phe Lys Asp Asn Leu Gly Lys Gln Arg Lys Tyr 1060 1065 1070
Thr Gly Ser Lys Met Leu Asp Leu Leu Arg Ala Leu Arg Asn Lys Arg
1075 1080 1085 Asn His Tyr Asn Asp Met Pro Glu His Leu Lys Ala His
Ile Gly Gly 1090 1095 1100 Leu Pro Glu Gly Tyr Leu Asn Phe Trp Thr
Val Arg Phe Pro Ser Leu 1105 1110 1115 1120Leu Met Ser Cys His Ser
Val Ile Val Glu Leu Arg Leu Thr Arg Ser 1125 1130 1135 Asp Arg Phe
Lys Arg Tyr Phe Thr Ala Thr Asp 1140 1145 102332DNAAspergillus
niger 10tcccttcttc ctcttctccc tctcccttta ccttccccgt gcagctactt
gactgttgag 60cttgccttcc tctccctctt tgatccaccc ttaccctctc cggaggttca
attgctggtg 120cgctctgttc gcctttgttt gttttccttc ccttcctctc
tcggacgttc tggttttaag 180agcgccggtc gctatccacc atgcgtttca
acgctgcttt gacttctgcc ctggtctcct 240cggcttccat catgggctat
gcccatgctg aggagaccga gaagaagccc gagaccacct 300ccttggccga
gaagcctacc ttcaccgtga gtaattctgc agaatgatat gaggtgctgc
360ccgcgccctg ctaactgcgt gcttccagcc cacctccatc gaggctcctt
tcttggagca 420gttcaccgat gactgggact cccggtggac tccctctcac
gctaagaagg aggactccaa 480gtccgaggaa gactgggcct atgttggtga
atggtccgtc gaggagccca ctgtcctcaa 540gggtatggag ggtgacaagg
gtctcgtcgt caagaacgtc gctgcccacc acgccatctc 600ggctaagttt
cccaagaaga tcgacaacaa ggacaagact ctggtcgtcc agtatgaggt
660gaagccgcag agtaagtgtg acaattgctg cgcatgctgg gtgctgggac
actaacgata 720gtcacagact cccttgtctg cggtggtgcc tacctgaagc
tcctccagga caacaagcag 780ctccacctcg acgagttctc gaacgcgtct
ccctacgtga tcatgttcgg tcccgacaag 840tgtggtgcca ccaacaaggt
aagatcttgc taaacgctgc ttagtgcagg tgactgcaac 900agggactaac
agctctatct tttttaggtt cacttcatct tccgtcacaa gaaccccaag
960accggcgagt acgaggagaa gcaccttaag gcacctcccg ccgcccgtac
ctccaaggtt 1020acctccgttt acaccctggt cgtcaacccc gatcagacct
tccagatcct gattgatggc 1080gagtccgtca aggaaggttc cctccttgag
gacttcaacc cccctgtcaa ccccgagaag 1140gagatcgacg accccaagga
caagaagccc gccgactggg ttgatgaggc caagatcccc 1200gaccctgagg
ctacgaagcc cgaggactgg gacgaggagg ctcccttcga gattgtcgac
1260gaggaggcta ccattcccga ggactggctc gaggacgagc ccactagcat
ccctgaccct 1320gaggccgaga agcccgagga ctgggatgat gaggaggatg
gcgactgggt tcctcccact 1380gttcccaacc ccaagtgcca ggatgcctcc
ggatgtggtc cttggtctcc ccctatgaag 1440aagaaccctg actacaaggg
caagtggtct gctcccttga ttgacaaccc ggcctacaag 1500ggaccctggg
ccccccgcaa gattgccaac cccgcctact tcgaggacaa gactccctcc
1560aactttgagc ccatgggcgc tgtaagtgta cctcttaatt ctaatgctaa
ggctttggat 1620gactaatgat gatgcagatt ggtttcgaga tttggaccat
gcagaacgac atcctgttcg 1680acaacatcta cgttggtcac tccgccgagg
atgccgagaa gctgcgccag gagaccttcg 1740atgtcaagca ccccattgag
ctggctgagg aggaggccaa caagcccaag cctgaagaga 1800aggccgccga
acccagcgtt agcttcaagg aagaccccgt gggccacatc aaggagaagg
1860tcgacaactt tgtccgcctc tccaagcagg accccatcaa cgccgtgaag
caggttcctg 1920acgttgccgg tggtcttgcc gctgttctcg tcacaatgat
ccttgtcatc gtcggagccg 1980ttggtgccag caccccggcc cctgcccccg
ccaagaaggg caaggaggct gctggtgcta 2040ccaaggagaa gactggtgcg
gcctccagct cctccgcaga cactggcaag ggtggtgcta 2100ccaagcgcac
tacccgctct tctgccgagt aaagtggtgc agctatcggt ggaacagcac
2160gcagggaaga aagggggaga gtttaaaagg cgaaaaggtc aaacaaacaa
acaaaccagg 2220gatatcctaa ctacattgtg tttttatttt atacctctgt
tgcagcgttc aatcaatgtt 2280tcattctgat tccatggtga gaaggccagc
tgggtatcag ctgccgccta ta 2332111689DNAAspergillus
nigerCDS(1)..(1689) 11atg cgt ttc aac gct gct ttg act tct gcc ctg
gtc tcc tcg gct tcc 48Met Arg Phe Asn Ala Ala Leu Thr Ser Ala Leu
Val Ser Ser Ala Ser 1 5 10 15 atc atg ggc tat gcc cat gct gag gag
acc gag aag aag ccc gag acc 96Ile Met Gly Tyr Ala His Ala Glu Glu
Thr Glu Lys Lys Pro Glu Thr 20 25 30 acc tcc ttg gcc gag aag cct
acc ttc acc ccc acc tcc atc gag gct 144Thr Ser Leu Ala Glu Lys Pro
Thr Phe Thr Pro Thr Ser Ile Glu Ala 35 40 45 cct ttc ttg gag cag
ttc acc gat gac tgg gac tcc cgg tgg act ccc 192Pro Phe Leu Glu Gln
Phe Thr Asp Asp Trp Asp Ser Arg Trp Thr Pro 50 55 60 tct cac gct
aag aag gag gac tcc aag tcc gag gaa gac tgg gcc tat 240Ser His Ala
Lys Lys Glu Asp Ser Lys Ser Glu Glu Asp Trp Ala Tyr 65 70 75 80 gtt
ggt gaa tgg tcc gtc gag gag ccc act gtc ctc aag ggt atg gag 288Val
Gly Glu Trp Ser Val Glu Glu Pro Thr Val Leu Lys Gly Met Glu 85 90
95 ggt gac aag ggt ctc gtc gtc aag aac gtc gct gcc cac cac gcc atc
336Gly Asp Lys Gly Leu Val Val Lys Asn Val Ala Ala His His Ala Ile
100 105 110 tcg gct aag ttt ccc aag aag atc gac aac aag gac aag act
ctg gtc 384Ser Ala Lys Phe Pro Lys Lys Ile Asp Asn Lys Asp Lys Thr
Leu Val 115 120 125 gtc cag tat gag gtg aag ccg cag aac tcc ctt gtc
tgc ggt ggt gcc 432Val Gln Tyr Glu Val Lys Pro Gln Asn Ser Leu Val
Cys Gly Gly Ala 130 135 140 tac ctg aag ctc ctc cag gac aac aag cag
ctc cac ctc gac gag ttc 480Tyr Leu Lys Leu Leu Gln Asp Asn Lys Gln
Leu His Leu Asp Glu Phe 145 150 155 160 tcg aac gcg tct ccc tac gtg
atc atg ttc ggt ccc gac aag tgt ggt 528Ser Asn Ala Ser Pro Tyr Val
Ile Met Phe Gly Pro Asp Lys Cys Gly 165 170 175 gcc acc aac aag gtt
cac ttc atc ttc cgt cac aag aac ccc aag acc 576Ala Thr Asn Lys Val
His Phe Ile Phe Arg His Lys Asn Pro Lys Thr 180 185 190 ggc gag tac
gag gag aag cac ctt aag gca cct ccc gcc gcc cgt acc 624Gly Glu Tyr
Glu Glu Lys His Leu Lys
Ala Pro Pro Ala Ala Arg Thr 195 200 205 tcc aag gtt acc tcc gtt tac
acc ctg gtc gtc aac ccc gat cag acc 672Ser Lys Val Thr Ser Val Tyr
Thr Leu Val Val Asn Pro Asp Gln Thr 210 215 220 ttc cag atc ctg att
gat ggc gag tcc gtc aag gaa ggt tcc ctc ctt 720Phe Gln Ile Leu Ile
Asp Gly Glu Ser Val Lys Glu Gly Ser Leu Leu 225 230 235 240 gag gac
ttc aac ccc cct gtc aac ccc gag aag gag atc gac gac ccc 768Glu Asp
Phe Asn Pro Pro Val Asn Pro Glu Lys Glu Ile Asp Asp Pro 245 250 255
aag gac aag aag ccc gcc gac tgg gtt gat gag gcc aag atc ccc gac
816Lys Asp Lys Lys Pro Ala Asp Trp Val Asp Glu Ala Lys Ile Pro Asp
260 265 270 cct gag gct acg aag ccc gag gac tgg gac gag gag gct ccc
ttc gag 864Pro Glu Ala Thr Lys Pro Glu Asp Trp Asp Glu Glu Ala Pro
Phe Glu 275 280 285 att gtc gac gag gag gct acc att ccc gag gac tgg
ctc gag gac gag 912Ile Val Asp Glu Glu Ala Thr Ile Pro Glu Asp Trp
Leu Glu Asp Glu 290 295 300 ccc act agc atc cct gac cct gag gcc gag
aag ccc gag gac tgg gat 960Pro Thr Ser Ile Pro Asp Pro Glu Ala Glu
Lys Pro Glu Asp Trp Asp 305 310 315 320 gat gag gag gat ggc gac tgg
gtt cct ccc act gtt ccc aac ccc aag 1008Asp Glu Glu Asp Gly Asp Trp
Val Pro Pro Thr Val Pro Asn Pro Lys 325 330 335 tgc cag gat gcc tcc
gga tgt ggt cct tgg tct ccc cct atg aag aag 1056Cys Gln Asp Ala Ser
Gly Cys Gly Pro Trp Ser Pro Pro Met Lys Lys 340 345 350 aac cct gac
tac aag ggc aag tgg tct gct ccc ttg att gac aac ccg 1104Asn Pro Asp
Tyr Lys Gly Lys Trp Ser Ala Pro Leu Ile Asp Asn Pro 355 360 365 gcc
tac aag gga ccc tgg gcc ccc cgc aag att gcc aac ccc gcc tac 1152Ala
Tyr Lys Gly Pro Trp Ala Pro Arg Lys Ile Ala Asn Pro Ala Tyr 370 375
380 ttc gag gac aag act ccc tcc aac ttt gag ccc atg ggc gct att ggt
1200Phe Glu Asp Lys Thr Pro Ser Asn Phe Glu Pro Met Gly Ala Ile Gly
385 390 395 400 ttc gag att tgg acc atg cag aac gac atc ctg ttc gac
aac atc tac 1248Phe Glu Ile Trp Thr Met Gln Asn Asp Ile Leu Phe Asp
Asn Ile Tyr 405 410 415 gtt ggt cac tcc gcc gag gat gcc gag aag ctg
cgc cag gag acc ttc 1296Val Gly His Ser Ala Glu Asp Ala Glu Lys Leu
Arg Gln Glu Thr Phe 420 425 430 gat gtc aag cac ccc att gag ctg gct
gag gag gag gcc aac aag ccc 1344Asp Val Lys His Pro Ile Glu Leu Ala
Glu Glu Glu Ala Asn Lys Pro 435 440 445 aag cct gaa gag aag gcc gcc
gaa ccc agc gtt agc ttc aag gaa gac 1392Lys Pro Glu Glu Lys Ala Ala
Glu Pro Ser Val Ser Phe Lys Glu Asp 450 455 460 ccc gtg ggc cac atc
aag gag aag gtc gac aac ttt gtc cgc ctc tcc 1440Pro Val Gly His Ile
Lys Glu Lys Val Asp Asn Phe Val Arg Leu Ser 465 470 475 480 aag cag
gac ccc atc aac gcc gtg aag cag gtt cct gac gtt gcc ggt 1488Lys Gln
Asp Pro Ile Asn Ala Val Lys Gln Val Pro Asp Val Ala Gly 485 490 495
ggt ctt gcc gct gtt ctc gtc aca atg atc ctt gtc atc gtc gga gcc
1536Gly Leu Ala Ala Val Leu Val Thr Met Ile Leu Val Ile Val Gly Ala
500 505 510 gtt ggt gcc agc acc ccg gcc cct gcc ccc gcc aag aag ggc
aag gag 1584Val Gly Ala Ser Thr Pro Ala Pro Ala Pro Ala Lys Lys Gly
Lys Glu 515 520 525 gct gct ggt gct acc aag gag aag act ggt gcg gcc
tcc agc tcc tcc 1632Ala Ala Gly Ala Thr Lys Glu Lys Thr Gly Ala Ala
Ser Ser Ser Ser 530 535 540 gca gac act ggc aag ggt ggt gct acc aag
cgc act acc cgc tct tct 1680Ala Asp Thr Gly Lys Gly Gly Ala Thr Lys
Arg Thr Thr Arg Ser Ser 545 550 555 560 gcc gag taa 1689Ala Glu
12562PRTAspergillus niger 12Met Arg Phe Asn Ala Ala Leu Thr Ser Ala
Leu Val Ser Ser Ala Ser 1 5 10 15 Ile Met Gly Tyr Ala His Ala Glu
Glu Thr Glu Lys Lys Pro Glu Thr 20 25 30 Thr Ser Leu Ala Glu Lys
Pro Thr Phe Thr Pro Thr Ser Ile Glu Ala 35 40 45 Pro Phe Leu Glu
Gln Phe Thr Asp Asp Trp Asp Ser Arg Trp Thr Pro 50 55 60 Ser His
Ala Lys Lys Glu Asp Ser Lys Ser Glu Glu Asp Trp Ala Tyr 65 70 75 80
Val Gly Glu Trp Ser Val Glu Glu Pro Thr Val Leu Lys Gly Met Glu 85
90 95 Gly Asp Lys Gly Leu Val Val Lys Asn Val Ala Ala His His Ala
Ile 100 105 110 Ser Ala Lys Phe Pro Lys Lys Ile Asp Asn Lys Asp Lys
Thr Leu Val 115 120 125 Val Gln Tyr Glu Val Lys Pro Gln Asn Ser Leu
Val Cys Gly Gly Ala 130 135 140 Tyr Leu Lys Leu Leu Gln Asp Asn Lys
Gln Leu His Leu Asp Glu Phe 145 150 155 160 Ser Asn Ala Ser Pro Tyr
Val Ile Met Phe Gly Pro Asp Lys Cys Gly 165 170 175 Ala Thr Asn Lys
Val His Phe Ile Phe Arg His Lys Asn Pro Lys Thr 180 185 190 Gly Glu
Tyr Glu Glu Lys His Leu Lys Ala Pro Pro Ala Ala Arg Thr 195 200 205
Ser Lys Val Thr Ser Val Tyr Thr Leu Val Val Asn Pro Asp Gln Thr 210
215 220 Phe Gln Ile Leu Ile Asp Gly Glu Ser Val Lys Glu Gly Ser Leu
Leu 225 230 235 240 Glu Asp Phe Asn Pro Pro Val Asn Pro Glu Lys Glu
Ile Asp Asp Pro 245 250 255 Lys Asp Lys Lys Pro Ala Asp Trp Val Asp
Glu Ala Lys Ile Pro Asp 260 265 270 Pro Glu Ala Thr Lys Pro Glu Asp
Trp Asp Glu Glu Ala Pro Phe Glu 275 280 285 Ile Val Asp Glu Glu Ala
Thr Ile Pro Glu Asp Trp Leu Glu Asp Glu 290 295 300 Pro Thr Ser Ile
Pro Asp Pro Glu Ala Glu Lys Pro Glu Asp Trp Asp 305 310 315 320 Asp
Glu Glu Asp Gly Asp Trp Val Pro Pro Thr Val Pro Asn Pro Lys 325 330
335 Cys Gln Asp Ala Ser Gly Cys Gly Pro Trp Ser Pro Pro Met Lys Lys
340 345 350 Asn Pro Asp Tyr Lys Gly Lys Trp Ser Ala Pro Leu Ile Asp
Asn Pro 355 360 365 Ala Tyr Lys Gly Pro Trp Ala Pro Arg Lys Ile Ala
Asn Pro Ala Tyr 370 375 380 Phe Glu Asp Lys Thr Pro Ser Asn Phe Glu
Pro Met Gly Ala Ile Gly 385 390 395 400 Phe Glu Ile Trp Thr Met Gln
Asn Asp Ile Leu Phe Asp Asn Ile Tyr 405 410 415 Val Gly His Ser Ala
Glu Asp Ala Glu Lys Leu Arg Gln Glu Thr Phe 420 425 430 Asp Val Lys
His Pro Ile Glu Leu Ala Glu Glu Glu Ala Asn Lys Pro 435 440 445 Lys
Pro Glu Glu Lys Ala Ala Glu Pro Ser Val Ser Phe Lys Glu Asp 450 455
460 Pro Val Gly His Ile Lys Glu Lys Val Asp Asn Phe Val Arg Leu Ser
465 470 475 480 Lys Gln Asp Pro Ile Asn Ala Val Lys Gln Val Pro Asp
Val Ala Gly 485 490 495 Gly Leu Ala Ala Val Leu Val Thr Met Ile Leu
Val Ile Val Gly Ala 500 505 510 Val Gly Ala Ser Thr Pro Ala Pro Ala
Pro Ala Lys Lys Gly Lys Glu 515 520 525 Ala Ala Gly Ala Thr Lys Glu
Lys Thr Gly Ala Ala Ser Ser Ser Ser 530 535 540 Ala Asp Thr Gly Lys
Gly Gly Ala Thr Lys Arg Thr Thr Arg Ser Ser 545 550 555 560 Ala Glu
132097DNAAspergillus niger 13gccgcggcgg tcgccgtacg taattcgtaa
tcccgcatcg ggacacctca gcatctccgc 60gcgtctttct ccccctcgac tatcgccaat
tcttccacct tccgtccatc ctctcgctca 120tttctttctc cttgggacta
tctcctggtg agtgtatagg tcctaggcgc ggtcgttgag 180agaccgccca
tctgcccact atgaggccgt ttaccgcact tgctgcgctg tgcggcttgt
240tcctgtccag caacagcttg gtctatgccg actcggctcc ctcgagctcc
cctgtagctc 300tccctcgcga tttcaagcct ccccaagtgt ttaagaacgc
caatcttgtc cgcaacacca 360atttggagaa gggataccta cgtgagaccg
tcaatgttgt cgttgagaat gtggacaaga 420agccgcagtc cgactactac
ttgtccttcc catccgacct ttacgacaag gtcggtgccc 480tagaagtccg
tgataaatcg gctcctgaac agggacgctt cgaagtggaa gctactgagt
540tcgactcaag caggtaagtc gaccacaatg gcggccaatg gctggttggt
ggagcacgaa 600gccacggttg cttgatctat gcatggtgga tgtatcccgg
gcggtttgct gatctcctct 660ctttctttac acagggactt ccagtacttc
gttgttcacc tccccaagcc tctcgcccct 720tcgtcgcaga tcactctggg
catctcctac tccgccctca acaccctgaa gccccgtcct 780gcggccatca
gccagaatga tcgccagtac ctcgcctatg ccttctctgc ctacgctccc
840tcggcttaca cgacaacgac ccagaagacc aagatcaagt tccccagcac
caatgttccc 900gactacacct ccacggacct gacgtcgggc gcggatccag
agcgccaggg tgccacctac 960acctacggac cctacgccga cgtcgctccc
gagaccacct acccggccag tgtccggtac 1020gagttcacca agcccgtcat
cactgccact cttctggagc gtgacctgga agtgtcccac 1080tggggcggca
acctggcgac ggaagagcgc tactggctgc gcaacaacgg ctccaagctc
1140accgacaact tcaaccgcgt ggaatggacc atcagcagct accagcagct
gccgtcctcc 1200gctatccgcg agctgaagat ccccctcaag cccggctccg
tggaccccta cttcaccgac 1260gacattggca acgtttccac gagccgctac
cgtcccggaa aggtcccgaa ccgtgacgcc 1320tccctggagc ttcgtccccg
gttccccatc ttcggcggat ggaactacag cttccgcatt 1380ggctggaaca
acgacctctc tgccttcctt cgcaaggctg tcaccggcgc tgattcctac
1440gtcctcaagg tccccttcat cgagggcccc aaggtttccg agggtattca
gtatgagaag 1500gccgtcgtgc gcatcatcct ccccgagggt gcccggaacg
tccgctacga gctcctcgag 1560aaggcgacta gcaatggtct ccccggtgcg
aaccagatcc agactgagct caccagccac 1620aagactttca tggataccct
aggacgcacg gcgctgactt tgaccgtgga ggagttgact 1680gatgaggccc
gtgactcgca gatagtggta agtaactacc tccatacgcc ggatagatat
1740cgggaatagt ccagctcatt tttggatata ggtcacttac gactactctc
tgtgggatgg 1800attgcgcaag cccgtgacca tcacggcggg gctgttcacc
gtgtttgttg ccgcgtgggc 1860gattggaaat attgacgtga gtattaagaa
gcggtagatg gaggttgtat catattgttt 1920cagttatacc agccagacag
acagacagaa ttcaatagta gctgtttgta gacgactaga 1980attctgatag
tgtgatttcg aatgattccc tccttgaata atatggagac agtctgatgc
2040agagtggtct ttgcaccagg tagtaagtgg gctatcggtt gtcagcgtca cctgaca
2097141512DNAAspergillus nigerCDS(1)..(1512) 14atg agg ccg ttt acc
gca ctt gct gcg ctg tgc ggc ttg ttc ctg tcc 48Met Arg Pro Phe Thr
Ala Leu Ala Ala Leu Cys Gly Leu Phe Leu Ser 1 5 10 15 agc aac agc
ttg gtc tat gcc gac tcg gct ccc tcg agc tcc cct gta 96Ser Asn Ser
Leu Val Tyr Ala Asp Ser Ala Pro Ser Ser Ser Pro Val 20 25 30 gct
ctc cct cgc gat ttc aag cct ccc caa gtg ttt aag aac gcc aat 144Ala
Leu Pro Arg Asp Phe Lys Pro Pro Gln Val Phe Lys Asn Ala Asn 35 40
45 ctt gtc cgc aac acc aat ttg gag aag gga tac cta cgt gag acc gtc
192Leu Val Arg Asn Thr Asn Leu Glu Lys Gly Tyr Leu Arg Glu Thr Val
50 55 60 aat gtt gtc gtt gag aat gtg gac aag aag ccg cag tcc gac
tac tac 240Asn Val Val Val Glu Asn Val Asp Lys Lys Pro Gln Ser Asp
Tyr Tyr 65 70 75 80 ttg tcc ttc cca tcc gac ctt tac gac aag gtc ggt
gcc cta gaa gtc 288Leu Ser Phe Pro Ser Asp Leu Tyr Asp Lys Val Gly
Ala Leu Glu Val 85 90 95 cgt gat aaa tcg gct cct gaa cag gga cgc
ttc gaa gtg gaa gct act 336Arg Asp Lys Ser Ala Pro Glu Gln Gly Arg
Phe Glu Val Glu Ala Thr 100 105 110 gag ttc gac tca agc agg gac ttc
cag tac ttc gtt gtt cac ctc ccc 384Glu Phe Asp Ser Ser Arg Asp Phe
Gln Tyr Phe Val Val His Leu Pro 115 120 125 aag cct ctc gcc cct tcg
tcg cag atc act ctg ggc atc tcc tac tcc 432Lys Pro Leu Ala Pro Ser
Ser Gln Ile Thr Leu Gly Ile Ser Tyr Ser 130 135 140 gcc ctc aac acc
ctg aag ccc cgt cct gcg gcc atc agc cag aat gat 480Ala Leu Asn Thr
Leu Lys Pro Arg Pro Ala Ala Ile Ser Gln Asn Asp 145 150 155 160 cgc
cag tac ctc gcc tat gcc ttc tct gcc tac gct ccc tcg gct tac 528Arg
Gln Tyr Leu Ala Tyr Ala Phe Ser Ala Tyr Ala Pro Ser Ala Tyr 165 170
175 acg aca acg acc cag aag acc aag atc aag ttc ccc agc acc aat gtt
576Thr Thr Thr Thr Gln Lys Thr Lys Ile Lys Phe Pro Ser Thr Asn Val
180 185 190 ccc gac tac acc tcc acg gac ctg acg tcg ggc gcg gat cca
gag cgc 624Pro Asp Tyr Thr Ser Thr Asp Leu Thr Ser Gly Ala Asp Pro
Glu Arg 195 200 205 cag ggt gcc acc tac acc tac gga ccc tac gcc gac
gtc gct ccc gag 672Gln Gly Ala Thr Tyr Thr Tyr Gly Pro Tyr Ala Asp
Val Ala Pro Glu 210 215 220 acc acc tac ccg gcc agt gtc cgg tac gag
ttc acc aag ccc gtc atc 720Thr Thr Tyr Pro Ala Ser Val Arg Tyr Glu
Phe Thr Lys Pro Val Ile 225 230 235 240 act gcc act ctt ctg gag cgt
gac ctg gaa gtg tcc cac tgg ggc ggc 768Thr Ala Thr Leu Leu Glu Arg
Asp Leu Glu Val Ser His Trp Gly Gly 245 250 255 aac ctg gcg acg gaa
gag cgc tac tgg ctg cgc aac aac ggc tcc aag 816Asn Leu Ala Thr Glu
Glu Arg Tyr Trp Leu Arg Asn Asn Gly Ser Lys 260 265 270 ctc acc gac
aac ttc aac cgc gtg gaa tgg acc atc agc agc tac cag 864Leu Thr Asp
Asn Phe Asn Arg Val Glu Trp Thr Ile Ser Ser Tyr Gln 275 280 285 cag
ctg ccg tcc tcc gct atc cgc gag ctg aag atc ccc ctc aag ccc 912Gln
Leu Pro Ser Ser Ala Ile Arg Glu Leu Lys Ile Pro Leu Lys Pro 290 295
300 ggc tcc gtg gac ccc tac ttc acc gac gac att ggc aac gtt tcc acg
960Gly Ser Val Asp Pro Tyr Phe Thr Asp Asp Ile Gly Asn Val Ser Thr
305 310 315 320 agc cgc tac cgt ccc gga aag gtc ccg aac cgt gac gcc
tcc ctg gag 1008Ser Arg Tyr Arg Pro Gly Lys Val Pro Asn Arg Asp Ala
Ser Leu Glu 325 330 335 ctt cgt ccc cgg ttc ccc atc ttc ggc gga tgg
aac tac agc ttc cgc 1056Leu Arg Pro Arg Phe Pro Ile Phe Gly Gly Trp
Asn Tyr Ser Phe Arg 340 345 350 att ggc tgg aac aac gac ctc tct gcc
ttc ctt cgc aag gct gtc acc 1104Ile Gly Trp Asn Asn Asp Leu Ser Ala
Phe Leu Arg Lys Ala Val Thr 355 360 365 ggc gct gat tcc tac gtc ctc
aag gtc ccc ttc atc gag ggc ccc aag 1152Gly Ala Asp Ser Tyr Val Leu
Lys Val Pro Phe Ile Glu Gly Pro Lys 370 375 380 gtt tcc gag ggt att
cag tat gag aag gcc gtc gtg cgc atc atc ctc 1200Val Ser Glu Gly Ile
Gln Tyr Glu Lys Ala Val Val Arg Ile Ile Leu 385 390 395 400 ccc gag
ggt gcc cgg aac gtc cgc tac gag ctc ctc gag aag gcg act 1248Pro Glu
Gly Ala Arg Asn Val Arg Tyr Glu Leu Leu Glu Lys Ala Thr 405 410 415
agc aat ggt ctc ccc ggt gcg aac cag atc cag act gag ctc acc agc
1296Ser Asn Gly Leu Pro Gly Ala Asn Gln Ile Gln Thr Glu Leu Thr Ser
420 425 430 cac aag act ttc atg gat acc cta gga cgc acg gcg ctg act
ttg acc 1344His Lys Thr Phe Met Asp Thr Leu Gly Arg Thr Ala Leu Thr
Leu Thr 435 440 445 gtg gag gag ttg act gat gag gcc cgt gac tcg cag
ata gtg gtc act 1392Val Glu Glu Leu Thr Asp Glu Ala Arg Asp Ser Gln
Ile Val Val Thr 450 455 460 tac gac tac tct ctg tgg gat gga ttg cgc
aag ccc gtg acc atc acg 1440Tyr Asp Tyr Ser Leu Trp Asp Gly Leu Arg
Lys Pro Val Thr Ile Thr 465 470 475 480 gcg ggg ctg ttc acc gtg ttt
gtt gcc gcg tgg gcg att gga aat att 1488Ala Gly Leu Phe Thr Val Phe
Val Ala Ala Trp Ala Ile Gly Asn Ile 485 490 495 gac gtg agt att aag
aag cgg tag 1512Asp Val Ser Ile Lys Lys Arg 500 15503PRTAspergillus
niger 15Met Arg Pro Phe Thr Ala Leu Ala Ala Leu Cys Gly Leu Phe Leu
Ser 1 5 10 15 Ser Asn Ser Leu Val Tyr Ala Asp Ser Ala Pro Ser Ser
Ser Pro Val 20
25 30 Ala Leu Pro Arg Asp Phe Lys Pro Pro Gln Val Phe Lys Asn Ala
Asn 35 40 45 Leu Val Arg Asn Thr Asn Leu Glu Lys Gly Tyr Leu Arg
Glu Thr Val 50 55 60 Asn Val Val Val Glu Asn Val Asp Lys Lys Pro
Gln Ser Asp Tyr Tyr 65 70 75 80 Leu Ser Phe Pro Ser Asp Leu Tyr Asp
Lys Val Gly Ala Leu Glu Val 85 90 95 Arg Asp Lys Ser Ala Pro Glu
Gln Gly Arg Phe Glu Val Glu Ala Thr 100 105 110 Glu Phe Asp Ser Ser
Arg Asp Phe Gln Tyr Phe Val Val His Leu Pro 115 120 125 Lys Pro Leu
Ala Pro Ser Ser Gln Ile Thr Leu Gly Ile Ser Tyr Ser 130 135 140 Ala
Leu Asn Thr Leu Lys Pro Arg Pro Ala Ala Ile Ser Gln Asn Asp 145 150
155 160 Arg Gln Tyr Leu Ala Tyr Ala Phe Ser Ala Tyr Ala Pro Ser Ala
Tyr 165 170 175 Thr Thr Thr Thr Gln Lys Thr Lys Ile Lys Phe Pro Ser
Thr Asn Val 180 185 190 Pro Asp Tyr Thr Ser Thr Asp Leu Thr Ser Gly
Ala Asp Pro Glu Arg 195 200 205 Gln Gly Ala Thr Tyr Thr Tyr Gly Pro
Tyr Ala Asp Val Ala Pro Glu 210 215 220 Thr Thr Tyr Pro Ala Ser Val
Arg Tyr Glu Phe Thr Lys Pro Val Ile 225 230 235 240 Thr Ala Thr Leu
Leu Glu Arg Asp Leu Glu Val Ser His Trp Gly Gly 245 250 255 Asn Leu
Ala Thr Glu Glu Arg Tyr Trp Leu Arg Asn Asn Gly Ser Lys 260 265 270
Leu Thr Asp Asn Phe Asn Arg Val Glu Trp Thr Ile Ser Ser Tyr Gln 275
280 285 Gln Leu Pro Ser Ser Ala Ile Arg Glu Leu Lys Ile Pro Leu Lys
Pro 290 295 300 Gly Ser Val Asp Pro Tyr Phe Thr Asp Asp Ile Gly Asn
Val Ser Thr 305 310 315 320 Ser Arg Tyr Arg Pro Gly Lys Val Pro Asn
Arg Asp Ala Ser Leu Glu 325 330 335 Leu Arg Pro Arg Phe Pro Ile Phe
Gly Gly Trp Asn Tyr Ser Phe Arg 340 345 350 Ile Gly Trp Asn Asn Asp
Leu Ser Ala Phe Leu Arg Lys Ala Val Thr 355 360 365 Gly Ala Asp Ser
Tyr Val Leu Lys Val Pro Phe Ile Glu Gly Pro Lys 370 375 380 Val Ser
Glu Gly Ile Gln Tyr Glu Lys Ala Val Val Arg Ile Ile Leu 385 390 395
400 Pro Glu Gly Ala Arg Asn Val Arg Tyr Glu Leu Leu Glu Lys Ala Thr
405 410 415 Ser Asn Gly Leu Pro Gly Ala Asn Gln Ile Gln Thr Glu Leu
Thr Ser 420 425 430 His Lys Thr Phe Met Asp Thr Leu Gly Arg Thr Ala
Leu Thr Leu Thr 435 440 445 Val Glu Glu Leu Thr Asp Glu Ala Arg Asp
Ser Gln Ile Val Val Thr 450 455 460 Tyr Asp Tyr Ser Leu Trp Asp Gly
Leu Arg Lys Pro Val Thr Ile Thr 465 470 475 480 Ala Gly Leu Phe Thr
Val Phe Val Ala Ala Trp Ala Ile Gly Asn Ile 485 490 495 Asp Val Ser
Ile Lys Lys Arg 500 162212DNAAspergillus niger 16cttttctctt
tcggtagctt ctgctctacg cgtcacctgc cttcctctct ctccccaccc 60ctctccctcc
aaacgggccg gtctattatt tgttttcatt gactttcgag gatctccccg
120gaagccactg gaaaagcaga tatccattta aataccctct cccatcgtcc
tctattccgc 180tgctgcttct ttattacaag atgcgctcct tcgcgccttg
gctcgttagc cttctcggag 240catccgcggt ggttgcggct gctgataccg
agtctgatgt tatttcactg gatcaggaca 300catttgagag cttcatgaac
gagcacggtc tcgtgcttgc cgaattcttt gctccttggt 360gtggccactg
taaagccctc gcaccaaagt atgaggaagc agctacggag ctcaaggcga
420agaatatccc tctggtgaag gttgactgca ccgccgagga ggatctctgc
cggagtcagg 480gcgttgaagg ctaccctacc ctcaagatct ttcggggtgt
tgactctagc aagccttacc 540agggcgctag gcaaacagaa tcgtgagtcc
tcttggtttt gactggacga aagaaatgga 600tatgcatcaa aaggctatcg
tgtatgtgat gtgctactga cccatcggac ggtttcccag 660aatcgtttcc
tacatgatta agcagtcact tcctgcagta tcctccgtga acgaggagaa
720tttagaagag atcaagacca tggacaagat tgtcgtgatc ggttatatcc
cgtccgagga 780ccaggaaact tatcaagcat tcgaaaaata tgctgagtct
cagcgggata actacctctt 840tgctgccacg gacgatgccg ccattgcgaa
atcggaaggt gtcgagcagc cctccatcgt 900gctctataag gacttcgatg
agaagaaggc tgtttacgat ggcgagatcg aacaggaggc 960tattcacagc
tgggtgaaat ccgctagtac tccccttgtg ggcgagattg gccctgagac
1020ctactctggc tatattgggg taagttgaat ctatacgtcg acgtgacatc
tctttgcatt 1080tcggcttgag tttcgatacc aatttgctgg ctgaactggc
taaccacttt tcttataggc 1140tggagtccca ttggcctata tctttgccga
gaccaaggag gagcgcgaaa agtacaccga 1200agacttcaag cctattgccc
agaagcacaa gggtgctatc aacattgcta ctattgacgc 1260caagatgttc
ggtgcccacg ctggaaacct caacctagac tctcagaagt tcccggcatt
1320cgccatccag gatcccgcaa agaacgccaa atacccctat gaccaggcca
aggaattgaa 1380tgccgacgag gttgaaaagt tcatccagga tgttctggat
gggaaggtcg agcctagcat 1440caagtcggaa cctgttcccg aatctcagga
gggccccgtc acggttgtag tggcccattc 1500ctacaaggat ctcgtcattg
acaatgacaa ggatgtcttg ctcgaattct acgcaccttg 1560gtgtggacac
tgcaaagcgt atgtctcttc gatcccctaa gtacactagg tgttggagca
1620caatcaacta acagcaaatc tatagtcttg ctccgaagta cgatgagctc
gcagctctct 1680atgctgacca ccccgatttg gcggctaagg tcaccatcgc
taagatcgat gcgacggcca 1740acgatgttcc ggacccgatt accggattcc
ctaccctcag actctacccg gccggtgcca 1800aggactcccc cattgagtac
tctggctcgc gcactgtcga ggatcttgcc aactttgtga 1860aggagaatgg
caaacacaac gttgacgccc tcaatgtcgc ttccgaggaa acacaggagg
1920gtggtgatgt gactgaggct gctccctccg ctacggaggc cgagaccccg
gctgccacag 1980atgacgagaa ggcagaacat gacgaactgt aaacagtctc
ccaattgaga tcccgcttag 2040tgctgtgccg tatcaatcac taattatttg
gaacttcgtt tctctattgt taacttttgt 2100aatctctgga ccaatctgtt
gttggttgaa ttagctaaat tggaccagtt tctatatggc 2160cagacaatgt
gatgaatata taatttgctc cacgcatgtc tacctcgttc ca
2212171548DNAAspergillus nigerCDS(1)..(1548) 17atg cgc tcc ttc gcg
cct tgg ctc gtt agc ctt ctc gga gca tcc gcg 48Met Arg Ser Phe Ala
Pro Trp Leu Val Ser Leu Leu Gly Ala Ser Ala 1 5 10 15 gtg gtt gcg
gct gct gat acc gag tct gat gtt att tca ctg gat cag 96Val Val Ala
Ala Ala Asp Thr Glu Ser Asp Val Ile Ser Leu Asp Gln 20 25 30 gac
aca ttt gag agc ttc atg aac gag cac ggt ctc gtg ctt gcc gaa 144Asp
Thr Phe Glu Ser Phe Met Asn Glu His Gly Leu Val Leu Ala Glu 35 40
45 ttc ttt gct cct tgg tgt ggc cac tgt aaa gcc ctc gca cca aag tat
192Phe Phe Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Lys Tyr
50 55 60 gag gaa gca gct acg gag ctc aag gcg aag aat atc cct ctg
gtg aag 240Glu Glu Ala Ala Thr Glu Leu Lys Ala Lys Asn Ile Pro Leu
Val Lys 65 70 75 80 gtt gac tgc acc gcc gag gag gat ctc tgc cgg agt
cag ggc gtt gaa 288Val Asp Cys Thr Ala Glu Glu Asp Leu Cys Arg Ser
Gln Gly Val Glu 85 90 95 ggc tac cct acc ctc aag atc ttt cgg ggt
gtt gac tct agc aag cct 336Gly Tyr Pro Thr Leu Lys Ile Phe Arg Gly
Val Asp Ser Ser Lys Pro 100 105 110 tac cag ggc gct agg caa aca gaa
tca atc gtt tcc tac atg att aag 384Tyr Gln Gly Ala Arg Gln Thr Glu
Ser Ile Val Ser Tyr Met Ile Lys 115 120 125 cag tca ctt cct gca gta
tcc tcc gtg aac gag gag aat tta gaa gag 432Gln Ser Leu Pro Ala Val
Ser Ser Val Asn Glu Glu Asn Leu Glu Glu 130 135 140 atc aag acc atg
gac aag att gtc gtg atc ggt tat atc ccg tcc gag 480Ile Lys Thr Met
Asp Lys Ile Val Val Ile Gly Tyr Ile Pro Ser Glu 145 150 155 160 gac
cag gaa act tat caa gca ttc gaa aaa tat gct gag tct cag cgg 528Asp
Gln Glu Thr Tyr Gln Ala Phe Glu Lys Tyr Ala Glu Ser Gln Arg 165 170
175 gat aac tac ctc ttt gct gcc acg gac gat gcc gcc att gcg aaa tcg
576Asp Asn Tyr Leu Phe Ala Ala Thr Asp Asp Ala Ala Ile Ala Lys Ser
180 185 190 gaa ggt gtc gag cag ccc tcc atc gtg ctc tat aag gac ttc
gat gag 624Glu Gly Val Glu Gln Pro Ser Ile Val Leu Tyr Lys Asp Phe
Asp Glu 195 200 205 aag aag gct gtt tac gat ggc gag atc gaa cag gag
gct att cac agc 672Lys Lys Ala Val Tyr Asp Gly Glu Ile Glu Gln Glu
Ala Ile His Ser 210 215 220 tgg gtg aaa tcc gct agt act ccc ctt gtg
ggc gag att ggc cct gag 720Trp Val Lys Ser Ala Ser Thr Pro Leu Val
Gly Glu Ile Gly Pro Glu 225 230 235 240 acc tac tct ggc tat att ggg
gct gga gtc cca ttg gcc tat atc ttt 768Thr Tyr Ser Gly Tyr Ile Gly
Ala Gly Val Pro Leu Ala Tyr Ile Phe 245 250 255 gcc gag acc aag gag
gag cgc gaa aag tac acc gaa gac ttc aag cct 816Ala Glu Thr Lys Glu
Glu Arg Glu Lys Tyr Thr Glu Asp Phe Lys Pro 260 265 270 att gcc cag
aag cac aag ggt gct atc aac att gct act att gac gcc 864Ile Ala Gln
Lys His Lys Gly Ala Ile Asn Ile Ala Thr Ile Asp Ala 275 280 285 aag
atg ttc ggt gcc cac gct gga aac ctc aac cta gac tct cag aag 912Lys
Met Phe Gly Ala His Ala Gly Asn Leu Asn Leu Asp Ser Gln Lys 290 295
300 ttc ccg gca ttc gcc atc cag gat ccc gca aag aac gcc aaa tac ccc
960Phe Pro Ala Phe Ala Ile Gln Asp Pro Ala Lys Asn Ala Lys Tyr Pro
305 310 315 320 tat gac cag gcc aag gaa ttg aat gcc gac gag gtt gaa
aag ttc atc 1008Tyr Asp Gln Ala Lys Glu Leu Asn Ala Asp Glu Val Glu
Lys Phe Ile 325 330 335 cag gat gtt ctg gat ggg aag gtc gag cct agc
atc aag tcg gaa cct 1056Gln Asp Val Leu Asp Gly Lys Val Glu Pro Ser
Ile Lys Ser Glu Pro 340 345 350 gtt ccc gaa tct cag gag ggc ccc gtc
acg gtt gta gtg gcc cat tcc 1104Val Pro Glu Ser Gln Glu Gly Pro Val
Thr Val Val Val Ala His Ser 355 360 365 tac aag gat ctc gtc att gac
aat gac aag gat gtc ttg ctc gaa ttc 1152Tyr Lys Asp Leu Val Ile Asp
Asn Asp Lys Asp Val Leu Leu Glu Phe 370 375 380 tac gca cct tgg tgt
gga cac tgc aaa gct ctt gct ccg aag tac gat 1200Tyr Ala Pro Trp Cys
Gly His Cys Lys Ala Leu Ala Pro Lys Tyr Asp 385 390 395 400 gag ctc
gca gct ctc tat gct gac cac ccc gat ttg gcg gct aag gtc 1248Glu Leu
Ala Ala Leu Tyr Ala Asp His Pro Asp Leu Ala Ala Lys Val 405 410 415
acc atc gct aag atc gat gcg acg gcc aac gat gtt ccg gac ccg att
1296Thr Ile Ala Lys Ile Asp Ala Thr Ala Asn Asp Val Pro Asp Pro Ile
420 425 430 acc gga ttc cct acc ctc aga ctc tac ccg gcc ggt gcc aag
gac tcc 1344Thr Gly Phe Pro Thr Leu Arg Leu Tyr Pro Ala Gly Ala Lys
Asp Ser 435 440 445 ccc att gag tac tct ggc tcg cgc act gtc gag gat
ctt gcc aac ttt 1392Pro Ile Glu Tyr Ser Gly Ser Arg Thr Val Glu Asp
Leu Ala Asn Phe 450 455 460 gtg aag gag aat ggc aaa cac aac gtt gac
gcc ctc aat gtc gct tcc 1440Val Lys Glu Asn Gly Lys His Asn Val Asp
Ala Leu Asn Val Ala Ser 465 470 475 480 gag gaa aca cag gag ggt ggt
gat gtg act gag gct gct ccc tcc gct 1488Glu Glu Thr Gln Glu Gly Gly
Asp Val Thr Glu Ala Ala Pro Ser Ala 485 490 495 acg gag gcc gag acc
ccg gct gcc aca gat gac gag aag gca gaa cat 1536Thr Glu Ala Glu Thr
Pro Ala Ala Thr Asp Asp Glu Lys Ala Glu His 500 505 510 gac gaa ctg
taa 1548Asp Glu Leu 515 18515PRTAspergillus niger 18Met Arg Ser Phe
Ala Pro Trp Leu Val Ser Leu Leu Gly Ala Ser Ala 1 5 10 15 Val Val
Ala Ala Ala Asp Thr Glu Ser Asp Val Ile Ser Leu Asp Gln 20 25 30
Asp Thr Phe Glu Ser Phe Met Asn Glu His Gly Leu Val Leu Ala Glu 35
40 45 Phe Phe Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Lys
Tyr 50 55 60 Glu Glu Ala Ala Thr Glu Leu Lys Ala Lys Asn Ile Pro
Leu Val Lys 65 70 75 80 Val Asp Cys Thr Ala Glu Glu Asp Leu Cys Arg
Ser Gln Gly Val Glu 85 90 95 Gly Tyr Pro Thr Leu Lys Ile Phe Arg
Gly Val Asp Ser Ser Lys Pro 100 105 110 Tyr Gln Gly Ala Arg Gln Thr
Glu Ser Ile Val Ser Tyr Met Ile Lys 115 120 125 Gln Ser Leu Pro Ala
Val Ser Ser Val Asn Glu Glu Asn Leu Glu Glu 130 135 140 Ile Lys Thr
Met Asp Lys Ile Val Val Ile Gly Tyr Ile Pro Ser Glu 145 150 155 160
Asp Gln Glu Thr Tyr Gln Ala Phe Glu Lys Tyr Ala Glu Ser Gln Arg 165
170 175 Asp Asn Tyr Leu Phe Ala Ala Thr Asp Asp Ala Ala Ile Ala Lys
Ser 180 185 190 Glu Gly Val Glu Gln Pro Ser Ile Val Leu Tyr Lys Asp
Phe Asp Glu 195 200 205 Lys Lys Ala Val Tyr Asp Gly Glu Ile Glu Gln
Glu Ala Ile His Ser 210 215 220 Trp Val Lys Ser Ala Ser Thr Pro Leu
Val Gly Glu Ile Gly Pro Glu 225 230 235 240 Thr Tyr Ser Gly Tyr Ile
Gly Ala Gly Val Pro Leu Ala Tyr Ile Phe 245 250 255 Ala Glu Thr Lys
Glu Glu Arg Glu Lys Tyr Thr Glu Asp Phe Lys Pro 260 265 270 Ile Ala
Gln Lys His Lys Gly Ala Ile Asn Ile Ala Thr Ile Asp Ala 275 280 285
Lys Met Phe Gly Ala His Ala Gly Asn Leu Asn Leu Asp Ser Gln Lys 290
295 300 Phe Pro Ala Phe Ala Ile Gln Asp Pro Ala Lys Asn Ala Lys Tyr
Pro 305 310 315 320 Tyr Asp Gln Ala Lys Glu Leu Asn Ala Asp Glu Val
Glu Lys Phe Ile 325 330 335 Gln Asp Val Leu Asp Gly Lys Val Glu Pro
Ser Ile Lys Ser Glu Pro 340 345 350 Val Pro Glu Ser Gln Glu Gly Pro
Val Thr Val Val Val Ala His Ser 355 360 365 Tyr Lys Asp Leu Val Ile
Asp Asn Asp Lys Asp Val Leu Leu Glu Phe 370 375 380 Tyr Ala Pro Trp
Cys Gly His Cys Lys Ala Leu Ala Pro Lys Tyr Asp 385 390 395 400 Glu
Leu Ala Ala Leu Tyr Ala Asp His Pro Asp Leu Ala Ala Lys Val 405 410
415 Thr Ile Ala Lys Ile Asp Ala Thr Ala Asn Asp Val Pro Asp Pro Ile
420 425 430 Thr Gly Phe Pro Thr Leu Arg Leu Tyr Pro Ala Gly Ala Lys
Asp Ser 435 440 445 Pro Ile Glu Tyr Ser Gly Ser Arg Thr Val Glu Asp
Leu Ala Asn Phe 450 455 460 Val Lys Glu Asn Gly Lys His Asn Val Asp
Ala Leu Asn Val Ala Ser 465 470 475 480 Glu Glu Thr Gln Glu Gly Gly
Asp Val Thr Glu Ala Ala Pro Ser Ala 485 490 495 Thr Glu Ala Glu Thr
Pro Ala Ala Thr Asp Asp Glu Lys Ala Glu His 500 505 510 Asp Glu Leu
515 192113DNAAspergillus niger 19cccgcaatcc ccgtcgacct catcgcttcc
tccctttctc ctccatcctc tctctcttcc 60gtcgtctttt cttcttctcc ttctcctttt
gtacttcccc tccattcctt cagctggttc 120tcgcctccag ctttcctttc
tttctttccc tcccctttta ttcgagtaat cctgcagctc 180tgggaggtgc
aacagtcaca atgagcggac gtgagtcttg cacgcgatcg ctgccatctc
240cgcgacagcg ttccatcctt tacctcaatg gatcagcaaa tgctgatact
cgattctagt 300ccggtttctc gatctcatca agcccttcac gcccctcctc
ccggaggtgg ccgccccgga 360aaccaaggtt cccttcaacc agaagttgat
gtggacgggg gtacgtgata cttgtccagc 420tcgacatgag cttctaagct
aatggattac ccctgcagtt gaccctattg atcttcctgg 480tcatgagcca
gatgcccttg tacggaattg tctcctctga cacctccgac cctctgtact
540ggctccgtat gatgttggcc agtaaccggg gtaccctgat ggaactgggt
atcaccccca 600tcatctcctc tggcatggtt ttccaggtat gtaatgggga
aattgcaatc tgatcacgga 660tatcgggcat ttgctaatat gtggcttttg
tctgatagct tctcgctggt acccacctca 720tcgatgtcaa cctggacctg
aagaccgacc gtgaactgta tcagaccgct cagaagctct 780tcgctatcat
cctgtccttc ggtcaggcct gcgtctacgt cctcactggt ctttacggcc
840agcccagtga ccttggtgcc ggtatctgtg ttctgctgat tgttcagctg
gtcgttgctg 900gcttggttgt
catcctgctg gatgagctgc tccagaaggg ctatggtctt ggtagcggta
960tctctctgtt catcgcgacc aacatctgcg agtcgatcgt ctggaaggct
ttctctccta 1020cgaccatcaa cactggccgt ggtcccgagt ttgagggtgc
catcattgcc ctcttccacc 1080ttctgttgac ctggtccgac aagcagcgcg
ctctccgcga ggctttctac cgccagaacc 1140tccccaacat catgaacctg
ctggctactc tcctcgtttt cgccgctgtg atctacctcc 1200agggcttccg
tgttgagatc cctgtcaagt cctcccgcca gcgtggcatg cgtggttcct
1260accctgttcg cctgttctac acctccaaca tgcccatcat gcttcagtct
gctctgtgct 1320ccaacatctt cctcatcagt cagatgctgt actctcgctt
ctctgacaac ctccttgtca 1380agcttctcgg tgtttgggag cctcgtgagg
gttctgccca gctccacgcc gcctccggca 1440ttgcctacta catgtctcct
cccctgaact tcaaggaggc ccttcttgac cccattcaca 1500ccgccgttta
catcaccttc atgctggttg cttgtgctct cttctccaag acctggattg
1560aggtttccgg ctctgctccc cgcgatgttg ccaagcagct caaggaccag
ggtctcgtga 1620tggctggtca ccgtgagcag agcatgtaca aggagctcaa
gcgcgtcatc cctactgctg 1680ctgctttcgg tggtgcctgc attggtgccc
tgtccgtcgc ttctgacctg cttggtgctc 1740ttggcagcgg tactggtatc
ctccttgccg ttacgtaagt cttcactttg gtctcagatt 1800ttctgaagtg
gatactaaca ttcaaatgca ggattatata cggatacttt gaaattgccg
1860cccgtgaggg cgacattgga tcgggcctca agggccttgt tccgggtaac
tagataaggc 1920cccctttttg atgaaagcat gagaagaagt ttgagggctt
atgtttgttc ttgcaacttt 1980ctgtttcttc tcaggtagtg tgctgttgtg
gctgggatct ggattattta gtttcttgat 2040ggatgtatgg ctagttttaa
caatttgcag gaggggaaga tcttctctac ggagatacgt 2100ccacgccaca gct
2113201437DNAAspergillus nigerCDS(1)..(1437) 20atg agc gga ctc cgg
ttt ctc gat ctc atc aag ccc ttc acg ccc ctc 48Met Ser Gly Leu Arg
Phe Leu Asp Leu Ile Lys Pro Phe Thr Pro Leu 1 5 10 15 ctc ccg gag
gtg gcc gcc ccg gaa acc aag gtt ccc ttc aac cag aag 96Leu Pro Glu
Val Ala Ala Pro Glu Thr Lys Val Pro Phe Asn Gln Lys 20 25 30 ttg
atg tgg acg ggg ttg acc cta ttg atc ttc ctg gtc atg agc cag 144Leu
Met Trp Thr Gly Leu Thr Leu Leu Ile Phe Leu Val Met Ser Gln 35 40
45 atg ccc ttg tac gga att gtc tcc tct gac acc tcc gac cct ctg tac
192Met Pro Leu Tyr Gly Ile Val Ser Ser Asp Thr Ser Asp Pro Leu Tyr
50 55 60 tgg ctc cgt atg atg ttg gcc agt aac cgg ggt acc ctg atg
gaa ctg 240Trp Leu Arg Met Met Leu Ala Ser Asn Arg Gly Thr Leu Met
Glu Leu 65 70 75 80 ggt atc acc ccc atc atc tcc tct ggc atg gtt ttc
cag ctt ctc gct 288Gly Ile Thr Pro Ile Ile Ser Ser Gly Met Val Phe
Gln Leu Leu Ala 85 90 95 ggt acc cac ctc atc gat gtc aac ctg gac
ctg aag acc gac cgt gaa 336Gly Thr His Leu Ile Asp Val Asn Leu Asp
Leu Lys Thr Asp Arg Glu 100 105 110 ctg tat cag acc gct cag aag ctc
ttc gct atc atc ctg tcc ttc ggt 384Leu Tyr Gln Thr Ala Gln Lys Leu
Phe Ala Ile Ile Leu Ser Phe Gly 115 120 125 cag gcc tgc gtc tac gtc
ctc act ggt ctt tac ggc cag ccc agt gac 432Gln Ala Cys Val Tyr Val
Leu Thr Gly Leu Tyr Gly Gln Pro Ser Asp 130 135 140 ctt ggt gcc ggt
atc tgt gtt ctg ctg att gtt cag ctg gtc gtt gct 480Leu Gly Ala Gly
Ile Cys Val Leu Leu Ile Val Gln Leu Val Val Ala 145 150 155 160 ggc
ttg gtt gtc atc ctg ctg gat gag ctg ctc cag aag ggc tat ggt 528Gly
Leu Val Val Ile Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly 165 170
175 ctt ggt agc ggt atc tct ctg ttc atc gcg acc aac atc tgc gag tcg
576Leu Gly Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Ser
180 185 190 atc gtc tgg aag gct ttc tct cct acg acc atc aac act ggc
cgt ggt 624Ile Val Trp Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr Gly
Arg Gly 195 200 205 ccc gag ttt gag ggt gcc atc att gcc ctc ttc cac
ctt ctg ttg acc 672Pro Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe His
Leu Leu Leu Thr 210 215 220 tgg tcc gac aag cag cgc gct ctc cgc gag
gct ttc tac cgc cag aac 720Trp Ser Asp Lys Gln Arg Ala Leu Arg Glu
Ala Phe Tyr Arg Gln Asn 225 230 235 240 ctc ccc aac atc atg aac ctg
ctg gct act ctc ctc gtt ttc gcc gct 768Leu Pro Asn Ile Met Asn Leu
Leu Ala Thr Leu Leu Val Phe Ala Ala 245 250 255 gtg atc tac ctc cag
ggc ttc cgt gtt gag atc cct gtc aag tcc tcc 816Val Ile Tyr Leu Gln
Gly Phe Arg Val Glu Ile Pro Val Lys Ser Ser 260 265 270 cgc cag cgt
ggc atg cgt ggt tcc tac cct gtt cgc ctg ttc tac acc 864Arg Gln Arg
Gly Met Arg Gly Ser Tyr Pro Val Arg Leu Phe Tyr Thr 275 280 285 tcc
aac atg ccc atc atg ctt cag tct gct ctg tgc tcc aac atc ttc 912Ser
Asn Met Pro Ile Met Leu Gln Ser Ala Leu Cys Ser Asn Ile Phe 290 295
300 ctc atc agt cag atg ctg tac tct cgc ttc tct gac aac ctc ctt gtc
960Leu Ile Ser Gln Met Leu Tyr Ser Arg Phe Ser Asp Asn Leu Leu Val
305 310 315 320 aag ctt ctc ggt gtt tgg gag cct cgt gag ggt tct gcc
cag ctc cac 1008Lys Leu Leu Gly Val Trp Glu Pro Arg Glu Gly Ser Ala
Gln Leu His 325 330 335 gcc gcc tcc ggc att gcc tac tac atg tct cct
ccc ctg aac ttc aag 1056Ala Ala Ser Gly Ile Ala Tyr Tyr Met Ser Pro
Pro Leu Asn Phe Lys 340 345 350 gag gcc ctt ctt gac ccc att cac acc
gcc gtt tac atc acc ttc atg 1104Glu Ala Leu Leu Asp Pro Ile His Thr
Ala Val Tyr Ile Thr Phe Met 355 360 365 ctg gtt gct tgt gct ctc ttc
tcc aag acc tgg att gag gtt tcc ggc 1152Leu Val Ala Cys Ala Leu Phe
Ser Lys Thr Trp Ile Glu Val Ser Gly 370 375 380 tct gct ccc cgc gat
gtt gcc aag cag ctc aag gac cag ggt ctc gtg 1200Ser Ala Pro Arg Asp
Val Ala Lys Gln Leu Lys Asp Gln Gly Leu Val 385 390 395 400 atg gct
ggt cac cgt gag cag agc atg tac aag gag ctc aag cgc gtc 1248Met Ala
Gly His Arg Glu Gln Ser Met Tyr Lys Glu Leu Lys Arg Val 405 410 415
atc cct act gct gct gct ttc ggt ggt gcc tgc att ggt gcc ctg tcc
1296Ile Pro Thr Ala Ala Ala Phe Gly Gly Ala Cys Ile Gly Ala Leu Ser
420 425 430 gtc gct tct gac ctg ctt ggt gct ctt ggc agc ggt act ggt
atc ctc 1344Val Ala Ser Asp Leu Leu Gly Ala Leu Gly Ser Gly Thr Gly
Ile Leu 435 440 445 ctt gcc gtt acg att ata tac gga tac ttt gaa att
gcc gcc cgt gag 1392Leu Ala Val Thr Ile Ile Tyr Gly Tyr Phe Glu Ile
Ala Ala Arg Glu 450 455 460 ggc gac att gga tcg ggc ctc aag ggc ctt
gtt ccg ggt aac tag 1437Gly Asp Ile Gly Ser Gly Leu Lys Gly Leu Val
Pro Gly Asn 465 470 475 21478PRTAspergillus niger 21Met Ser Gly Leu
Arg Phe Leu Asp Leu Ile Lys Pro Phe Thr Pro Leu 1 5 10 15 Leu Pro
Glu Val Ala Ala Pro Glu Thr Lys Val Pro Phe Asn Gln Lys 20 25 30
Leu Met Trp Thr Gly Leu Thr Leu Leu Ile Phe Leu Val Met Ser Gln 35
40 45 Met Pro Leu Tyr Gly Ile Val Ser Ser Asp Thr Ser Asp Pro Leu
Tyr 50 55 60 Trp Leu Arg Met Met Leu Ala Ser Asn Arg Gly Thr Leu
Met Glu Leu 65 70 75 80 Gly Ile Thr Pro Ile Ile Ser Ser Gly Met Val
Phe Gln Leu Leu Ala 85 90 95 Gly Thr His Leu Ile Asp Val Asn Leu
Asp Leu Lys Thr Asp Arg Glu 100 105 110 Leu Tyr Gln Thr Ala Gln Lys
Leu Phe Ala Ile Ile Leu Ser Phe Gly 115 120 125 Gln Ala Cys Val Tyr
Val Leu Thr Gly Leu Tyr Gly Gln Pro Ser Asp 130 135 140 Leu Gly Ala
Gly Ile Cys Val Leu Leu Ile Val Gln Leu Val Val Ala 145 150 155 160
Gly Leu Val Val Ile Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly 165
170 175 Leu Gly Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu
Ser 180 185 190 Ile Val Trp Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr
Gly Arg Gly 195 200 205 Pro Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe
His Leu Leu Leu Thr 210 215 220 Trp Ser Asp Lys Gln Arg Ala Leu Arg
Glu Ala Phe Tyr Arg Gln Asn 225 230 235 240 Leu Pro Asn Ile Met Asn
Leu Leu Ala Thr Leu Leu Val Phe Ala Ala 245 250 255 Val Ile Tyr Leu
Gln Gly Phe Arg Val Glu Ile Pro Val Lys Ser Ser 260 265 270 Arg Gln
Arg Gly Met Arg Gly Ser Tyr Pro Val Arg Leu Phe Tyr Thr 275 280 285
Ser Asn Met Pro Ile Met Leu Gln Ser Ala Leu Cys Ser Asn Ile Phe 290
295 300 Leu Ile Ser Gln Met Leu Tyr Ser Arg Phe Ser Asp Asn Leu Leu
Val 305 310 315 320 Lys Leu Leu Gly Val Trp Glu Pro Arg Glu Gly Ser
Ala Gln Leu His 325 330 335 Ala Ala Ser Gly Ile Ala Tyr Tyr Met Ser
Pro Pro Leu Asn Phe Lys 340 345 350 Glu Ala Leu Leu Asp Pro Ile His
Thr Ala Val Tyr Ile Thr Phe Met 355 360 365 Leu Val Ala Cys Ala Leu
Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 370 375 380 Ser Ala Pro Arg
Asp Val Ala Lys Gln Leu Lys Asp Gln Gly Leu Val 385 390 395 400 Met
Ala Gly His Arg Glu Gln Ser Met Tyr Lys Glu Leu Lys Arg Val 405 410
415 Ile Pro Thr Ala Ala Ala Phe Gly Gly Ala Cys Ile Gly Ala Leu Ser
420 425 430 Val Ala Ser Asp Leu Leu Gly Ala Leu Gly Ser Gly Thr Gly
Ile Leu 435 440 445 Leu Ala Val Thr Ile Ile Tyr Gly Tyr Phe Glu Ile
Ala Ala Arg Glu 450 455 460 Gly Asp Ile Gly Ser Gly Leu Lys Gly Leu
Val Pro Gly Asn 465 470 475 225117DNAAspergillus niger 22agctcgactg
ggcatcttta atgcctcatt ggtctataca ttaattatac tgaattggta 60attacattgt
tgccattgat cacctcgagc ttatccgccg cccgttatgt gtgcttgcta
120gctagcttat cgggaacagc tagctagtca acaccgctgc catcagctct
aggtatcatt 180tcccgtggtg ggctgtgacg atggtatctg gactggcaaa
tttcgcctca tggcgacttg 240catctgtatt gattgccggc ctgctggcta
tccagggacg cgctagtcca tcagtcaatg 300ttgctctcca agcttcgttt
gattccccac cttatctgat agagctactg taagtgaaat 360tcagacagat
ctagttggat gctcttgatt cctgggctga cctctatgta gcgaatccgc
420tgcggaggag aactccacct catacttccc gttactcgat cggatcgccg
acggtatttt 480cgatgacgct gttacggata aggacctata tgatcgcttc
ctggaggttg tgcgtgagga 540tggacactta cggacccctg aaagtctctc
atctttcaag ctgtcgctgg cgatgagatc 600cgccagtccg cggatcacgg
ctcactacca gtactacaat gcttcggttc aatattcgtt 660aatggccgcg
caggatgcgg tctgtcctgt ttgggtgcac tccgaaggaa agcaatactg
720ctcgtctact atggaacgcg cccagcagga tgttacgggt tctgagtgag
tggtaatctc 780aaatttgtgt ctacatgctg gtgactaacc gctacaatgt
agtgacccac gagaactccc 840tttcgatcgt gtcttcggag atccctctct
gcctccagcg attttgtatg cggatatagc 900gtccccgatg ttcaaggaat
ttcaccagtc actgagtacg atggcgaaag aaggacaagt 960ctcgtatcgc
gtgcgataca gacctcctca acattggtct ccacgtcctg tttttgtgtc
1020tggatacggt gtcgagctgg cgttaaagcg gacggactat attgtgattg
atgatagaga 1080cgcggaagaa agagggaccg gcagcattga gtccggaaag
tctgatgaga cagaagatga 1140tttggatgac ctgagacccc tgtcatcatc
cgaagtttct cggcttgggc tgaacacggt 1200cgggtatgtg ttggatagcg
atgacccgtt tgacacactt gtgaagctgt cacaggattt 1260ccccaaatac
tccgcacgtg ttgcggctca caacgtttcc accgagctgt tgcaagatgt
1320tcggtccagc agattgcgta tgcttccgcc ggggctcaac gtgctctgga
tcaacggtgt 1380tcagattgaa cctcgacaag tggacgcatt cactcttctg
gatcacttgc gtcgcgaaag 1440gaaattgatc gagaagttcc gaaacttagg
cctgtccgct acagatgctg tagagctttt 1500gtcacaccct ctgcttggag
aggccttggc acgggatggc cctcagcgtt acaactaccg 1560tgatgacatt
gagggaggtg gtgtcatcat gtggctgaac aatctcgaaa aggatgcgcg
1620ctatgaatcg tggcctagcg aactcgcagg agtaggtaca tccgggattc
tttattgcgg 1680agatgctaat gtctggtagt ttatgcaacg cacatatcca
ggccagcttc cggcagtccg 1740ccgcgattcc aacaatattg tctttcctgt
cgacttgacg agcactgaag atgctgatat 1800tgttgtcaag acaatccagg
tctttgtgaa gaacaaaatt cccgtcagat ttggtttgat 1860tccggtcaca
ttctcagacg gagcaattgc tcagctcaag gtcgctcatt accttcaaga
1920gacttttggt ctggccagtt ttatggatta ccttgaagcg gtaaggacta
actttcccgt 1980aaccaaattc cgctattgtt tgtcagttac taattggagc
agtcggcgtc caaaaataag 2040ttggcttctc cggataaggc ctgcttccag
gctgcaactc aggaccggag tcctcgtctg 2100gagaaggtgt ctctatctct
agatgaagtc ttgaataatg ctgtatatga cgcaacggta 2160tcaaagacaa
ctgcgtacct aaaccgtctg gggatgaagc acgagccatc acatgctttt
2220gttaacggca ttcctgtcac ccgcaatgac aaatgggcgc aggaaatgag
cacaaaaata 2280agcaaagata ctcagctaat tcagcagaag attgctgatg
ccgaggtcga tgaagatacc 2340tggttgccag aattgtttct ctcgcaggct
ttcgataggc gcaatccggc gatcgttcca 2400gaggacccga aagagatccg
ggctgtggac ttggtgcagc ttgcggactc ccaagagaag 2460ctcttcagtc
agattccacg tttagggcta gatgaaagca atgccttgga gagtgcccat
2520gccatcgttg ttggcaactt tgatgagaaa tccggttacg agctactcag
cgcggccctt 2580gagagccgaa aaacacatgg tgaagttgag atgcttttcc
tacacaatcc taagctcgag 2640gcgtcccccg catctaggtc tgtcgctgtt
cgtcgattgt tgaatggtgg caaagaggta 2700gatgccagcc agattttgga
ggcgatcgcc tcttccgcct cgccagcaga tgaggaagct 2760ggggatgcgg
cactcttctg ggaggctcag cgagctgtag tagaagagct tggactcgct
2820ccgggcgaaa gggcacttgt catcaacgga agggtcgttg gaccgattgc
agaagacacc 2880gccctgacct cagaggacct ggaccagcta ctgatatatg
agaagcaaaa gcggattact 2940ccggtagcaa aggcggtcaa agcccttgaa
ttcgacgaga agctttctga tccgctagac 3000tttgccaagc ttacctcgct
caccacgctg tccacgatct cggatgtgcc agagggcata 3060tatgagtcga
cttcggacat tcggttgaat ttgttcaaca gatggaacga ctcacaatca
3120gctatcactg tctccaattc cgatgatcca gcaattacca ttgtagcatc
tatcgatccg 3180acttcggaag ttgctcagaa gtggctacca attctaaaag
tactgtcgga gctggcaagt 3240gtcagagtga gattggtcct gaacccgcgc
gaggagatca aagagctgcc caccaagcgc 3300ttctatcgtt atgttctcga
ttcggagcca tcgttcaacg aagatgggtc ggtttcccgg 3360cccacagcct
ccttctcggg cgttcccgtc gaggcactcc tcaccctggg catggatgtt
3420ccctcttctt ggcttgtggc tcccaaggat tctatccacg atcttgacaa
tatcaagtta 3480agttccgtca aggacggctc gaatgtcgat gctatttacg
cattggaaca catcttgatc 3540gagggccact cccgggatat gaccacgaag
tccccaccta gaggagttca gcttgtcctt 3600ggaactgaga acaaccctca
cttctcggat acaatcatca tggccaatct cggatacttc 3660caattcaaag
cccaacctgg actgtggaac atcaacctca aaccgggccg tagcgaacgc
3720atcttcaccc tcgacagcgt aggcagcctc ggctacaacc cccaacctgg
cgacgaaaac 3780aacgaagtgg ccctcctctc cttccaaggc cgcacccttt
tcccgcgtgt ctcccgtaag 3840aagggctacg agaccgaaga cgtcctcgag
accaacccca aaccaggttc tgcgatggac 3900tacatgaata aggggttcaa
cttcgcctcc ggtatcctct ccagcgtcgg agtcggcacc 3960aaaggcagca
ctagcggcaa acaggctgac attaacatct tctccgtcgc cagtggacac
4020ctctacgagc gcatgctcaa cattatgatg gtctcagtga tgcgcaacac
caaccacagc 4080gtgaaattct ggttcatcga acaattcctc tccccgtcct
tcaagtcctt cctgcctcac 4140cttgcgaagg agtataactt ctcttacgaa
atggtcacct acaaatggcc acactggctc 4200cgggcccaga aagaaaagca
acgtgaaatc tggggctaca agatcctctt cctggacgtt 4260ctcttccctc
tcgacctcga caaagtcatc tttgtcgacg ccgaccagat agtccgcaca
4320gatatgtacg acctcgtcag ccttgacctc gaaggcgctc cgtacggctt
tactcccatg 4380tgcgactccc gccacgagat ggaaggcttc cgcttctgga
agcaggggta ctggaagaac 4440ttcctccgtg gtcaacccta ccatatctcc
gcgctttacg ttgtcgacct gaaccgcttc 4500cgtgccatcg ccgccggcga
tcgcctgcgt ggacagtacc agatgctgtc agctgacccc 4560gagagtttga
gcaacctgga ccaggatctg ccgaaccaca tgcagcatca tatcccgatc
4620aagagtctgc cgcaggagtg gctgtggtgt gagacttggt gctcggatga
gtcgcagtca 4680caggctcgga cgatcgacct gtgcaataac ccgatgacga
aggagccgaa gttggatcgt 4740gccaggaggc aggtacctga gtggacggag
tatgatgatg agattgcggc cttgtcgaag 4800agagttgccg ctgagaagca
gcaggggcag gtggaggaag aaagggccgg tgaatcgtac 4860cctgacgagg
atgaggaggg cgagacttcc tctggctggg ataaggatga gctttagcgg
4920gtttcgtttc aattatagcg tgtatacata gatcagtttg gtctccaata
gggaatagat 4980tgttcgcttt acaagtcttg gtatcgtttc gtgcatgata
ttcttttagt tgactgacct 5040aggatcgtaa tgccttggct tctcaatcct
ataagaccta cattgggaaa cacaagcatt 5100ctcttactcg agaaaca
5117234488DNAAspergillus nigerCDS(1)..(4488) 23atg gta tct gga ctg
gca aat ttc gcc tca tgg cga ctt gca tct gta 48Met Val Ser Gly Leu
Ala Asn Phe Ala Ser Trp Arg Leu Ala Ser Val 1 5 10 15 ttg att gcc
ggc ctg ctg gct atc cag gga cgc gct agt cca tca gtc 96Leu Ile Ala
Gly Leu Leu Ala Ile Gln Gly Arg Ala Ser Pro Ser Val 20 25 30 aat
gtt gct ctc caa gct tcg ttt gat tcc cca cct tat ctg ata gag 144Asn
Val Ala Leu Gln Ala Ser Phe Asp Ser Pro Pro Tyr Leu Ile Glu 35
40 45 cta ctc gaa tcc gct gcg gag gag aac tcc acc tca tac ttc ccg
tta 192Leu Leu Glu Ser Ala Ala Glu Glu Asn Ser Thr Ser Tyr Phe Pro
Leu 50 55 60 ctc gat cgg atc gcc gac ggt att ttc gat gac gct gtt
acg gat aag 240Leu Asp Arg Ile Ala Asp Gly Ile Phe Asp Asp Ala Val
Thr Asp Lys 65 70 75 80 gac cta tat gat cgc ttc ctg gag gtt gtg cgt
gag gat gga cac tta 288Asp Leu Tyr Asp Arg Phe Leu Glu Val Val Arg
Glu Asp Gly His Leu 85 90 95 cgg acc cct gaa agt ctc tca tct ttc
aag ctg tcg ctg gcg atg aga 336Arg Thr Pro Glu Ser Leu Ser Ser Phe
Lys Leu Ser Leu Ala Met Arg 100 105 110 tcc gcc agt ccg cgg atc acg
gct cac tac cag tac tac aat gct tcg 384Ser Ala Ser Pro Arg Ile Thr
Ala His Tyr Gln Tyr Tyr Asn Ala Ser 115 120 125 gtt caa tat tcg tta
atg gcc gcg cag gat gcg gtc tgt cct gtt tgg 432Val Gln Tyr Ser Leu
Met Ala Ala Gln Asp Ala Val Cys Pro Val Trp 130 135 140 gtg cac tcc
gaa gga aag caa tac tgc tcg tct act atg gaa cgc gcc 480Val His Ser
Glu Gly Lys Gln Tyr Cys Ser Ser Thr Met Glu Arg Ala 145 150 155 160
cag cag gat gtt acg ggt tct gat gac cca cga gaa ctc cct ttc gat
528Gln Gln Asp Val Thr Gly Ser Asp Asp Pro Arg Glu Leu Pro Phe Asp
165 170 175 cgt gtc ttc gga gat ccc tct ctg cct cca gcg att ttg tat
gcg gat 576Arg Val Phe Gly Asp Pro Ser Leu Pro Pro Ala Ile Leu Tyr
Ala Asp 180 185 190 ata gcg tcc ccg atg ttc aag gaa ttt cac cag tca
ctg agt acg atg 624Ile Ala Ser Pro Met Phe Lys Glu Phe His Gln Ser
Leu Ser Thr Met 195 200 205 gcg aaa gaa gga caa gtc tcg tat cgc gtg
cga tac aga cct cct caa 672Ala Lys Glu Gly Gln Val Ser Tyr Arg Val
Arg Tyr Arg Pro Pro Gln 210 215 220 cat tgg tct cca cgt cct gtt ttt
gtg tct gga tac ggt gtc gag ctg 720His Trp Ser Pro Arg Pro Val Phe
Val Ser Gly Tyr Gly Val Glu Leu 225 230 235 240 gcg tta aag cgg acg
gac tat att gtg att gat gat aga gac gcg gaa 768Ala Leu Lys Arg Thr
Asp Tyr Ile Val Ile Asp Asp Arg Asp Ala Glu 245 250 255 gaa aga ggg
acc ggc agc att gag tcc gga aag tct gat gag aca gaa 816Glu Arg Gly
Thr Gly Ser Ile Glu Ser Gly Lys Ser Asp Glu Thr Glu 260 265 270 gat
gat ttg gat gac ctg aga ccc ctg tca tca tcc gaa gtt tct cgg 864Asp
Asp Leu Asp Asp Leu Arg Pro Leu Ser Ser Ser Glu Val Ser Arg 275 280
285 ctt ggg ctg aac acg gtc ggg tat gtg ttg gat agc gat gac ccg ttt
912Leu Gly Leu Asn Thr Val Gly Tyr Val Leu Asp Ser Asp Asp Pro Phe
290 295 300 gac aca ctt gtg aag ctg tca cag gat ttc ccc aaa tac tcc
gca cgt 960Asp Thr Leu Val Lys Leu Ser Gln Asp Phe Pro Lys Tyr Ser
Ala Arg 305 310 315 320 gtt gcg gct cac aac gtt tcc acc gag ctg ttg
caa gat gtt cgg tcc 1008Val Ala Ala His Asn Val Ser Thr Glu Leu Leu
Gln Asp Val Arg Ser 325 330 335 agc aga ttg cgt atg ctt ccg ccg ggg
ctc aac gtg ctc tgg atc aac 1056Ser Arg Leu Arg Met Leu Pro Pro Gly
Leu Asn Val Leu Trp Ile Asn 340 345 350 ggt gtt cag att gaa cct cga
caa gtg gac gca ttc act ctt ctg gat 1104Gly Val Gln Ile Glu Pro Arg
Gln Val Asp Ala Phe Thr Leu Leu Asp 355 360 365 cac ttg cgt cgc gaa
agg aaa ttg atc gag aag ttc cga aac tta ggc 1152His Leu Arg Arg Glu
Arg Lys Leu Ile Glu Lys Phe Arg Asn Leu Gly 370 375 380 ctg tcc gct
aca gat gct gta gag ctt ttg tca cac cct ctg ctt gga 1200Leu Ser Ala
Thr Asp Ala Val Glu Leu Leu Ser His Pro Leu Leu Gly 385 390 395 400
gag gcc ttg gca cgg gat ggc cct cag cgt tac aac tac cgt gat gac
1248Glu Ala Leu Ala Arg Asp Gly Pro Gln Arg Tyr Asn Tyr Arg Asp Asp
405 410 415 att gag gga ggt ggt gtc atc atg tgg ctg aac aat ctc gaa
aag gat 1296Ile Glu Gly Gly Gly Val Ile Met Trp Leu Asn Asn Leu Glu
Lys Asp 420 425 430 gcg cgc tat gaa tcg tgg cct agc gaa ctc gca gga
ttt atg caa cgc 1344Ala Arg Tyr Glu Ser Trp Pro Ser Glu Leu Ala Gly
Phe Met Gln Arg 435 440 445 aca tat cca ggc cag ctt ccg gca gtc cgc
cgc gat tcc aac aat att 1392Thr Tyr Pro Gly Gln Leu Pro Ala Val Arg
Arg Asp Ser Asn Asn Ile 450 455 460 gtc ttt cct gtc gac ttg acg agc
act gaa gat gct gat att gtt gtc 1440Val Phe Pro Val Asp Leu Thr Ser
Thr Glu Asp Ala Asp Ile Val Val 465 470 475 480 aag aca atc cag gtc
ttt gtg aag aac aaa att ccc gtc aga ttt ggt 1488Lys Thr Ile Gln Val
Phe Val Lys Asn Lys Ile Pro Val Arg Phe Gly 485 490 495 ttg att ccg
gtc aca ttc tca gac gga gca att gct cag ctc aag gtc 1536Leu Ile Pro
Val Thr Phe Ser Asp Gly Ala Ile Ala Gln Leu Lys Val 500 505 510 gct
cat tac ctt caa gag act ttt ggt ctg gcc agt ttt atg gat tac 1584Ala
His Tyr Leu Gln Glu Thr Phe Gly Leu Ala Ser Phe Met Asp Tyr 515 520
525 ctt gaa gcg tcg gcg tcc aaa aat aag ttg gct tct ccg gat aag gcc
1632Leu Glu Ala Ser Ala Ser Lys Asn Lys Leu Ala Ser Pro Asp Lys Ala
530 535 540 tgc ttc cag gct gca act cag gac cgg agt cct cgt ctg gag
aag gtg 1680Cys Phe Gln Ala Ala Thr Gln Asp Arg Ser Pro Arg Leu Glu
Lys Val 545 550 555 560 tct cta tct cta gat gaa gtc ttg aat aat gct
gta tat gac gca acg 1728Ser Leu Ser Leu Asp Glu Val Leu Asn Asn Ala
Val Tyr Asp Ala Thr 565 570 575 gta tca aag aca act gcg tac cta aac
cgt ctg ggg atg aag cac gag 1776Val Ser Lys Thr Thr Ala Tyr Leu Asn
Arg Leu Gly Met Lys His Glu 580 585 590 cca tca cat gct ttt gtt aac
ggc att cct gtc acc cgc aat gac aaa 1824Pro Ser His Ala Phe Val Asn
Gly Ile Pro Val Thr Arg Asn Asp Lys 595 600 605 tgg gcg cag gaa atg
agc aca aaa ata agc aaa gat act cag cta att 1872Trp Ala Gln Glu Met
Ser Thr Lys Ile Ser Lys Asp Thr Gln Leu Ile 610 615 620 cag cag aag
att gct gat gcc gag gtc gat gaa gat acc tgg ttg cca 1920Gln Gln Lys
Ile Ala Asp Ala Glu Val Asp Glu Asp Thr Trp Leu Pro 625 630 635 640
gaa ttg ttt ctc tcg cag gct ttc gat agg cgc aat ccg gcg atc gtt
1968Glu Leu Phe Leu Ser Gln Ala Phe Asp Arg Arg Asn Pro Ala Ile Val
645 650 655 cca gag gac ccg aaa gag atc cgg gct gtg gac ttg gtg cag
ctt gcg 2016Pro Glu Asp Pro Lys Glu Ile Arg Ala Val Asp Leu Val Gln
Leu Ala 660 665 670 gac tcc caa gag aag ctc ttc agt cag att cca cgt
tta ggg cta gat 2064Asp Ser Gln Glu Lys Leu Phe Ser Gln Ile Pro Arg
Leu Gly Leu Asp 675 680 685 gaa agc aat gcc ttg gag agt gcc cat gcc
atc gtt gtt ggc aac ttt 2112Glu Ser Asn Ala Leu Glu Ser Ala His Ala
Ile Val Val Gly Asn Phe 690 695 700 gat gag aaa tcc ggt tac gag cta
ctc agc gcg gcc ctt gag agc cga 2160Asp Glu Lys Ser Gly Tyr Glu Leu
Leu Ser Ala Ala Leu Glu Ser Arg 705 710 715 720 aaa aca cat ggt gaa
gtt gag atg ctt ttc cta cac aat cct aag ctc 2208Lys Thr His Gly Glu
Val Glu Met Leu Phe Leu His Asn Pro Lys Leu 725 730 735 gag gcg tcc
ccc gca tct agg tct gtc gct gtt cgt cga ttg ttg aat 2256Glu Ala Ser
Pro Ala Ser Arg Ser Val Ala Val Arg Arg Leu Leu Asn 740 745 750 ggt
ggc aaa gag gta gat gcc agc cag att ttg gag gcg atc gcc tct 2304Gly
Gly Lys Glu Val Asp Ala Ser Gln Ile Leu Glu Ala Ile Ala Ser 755 760
765 tcc gcc tcg cca gca gat gag gaa gct ggg gat gcg gca ctc ttc tgg
2352Ser Ala Ser Pro Ala Asp Glu Glu Ala Gly Asp Ala Ala Leu Phe Trp
770 775 780 gag gct cag cga gct gta gta gaa gag ctt gga ctc gct ccg
ggc gaa 2400Glu Ala Gln Arg Ala Val Val Glu Glu Leu Gly Leu Ala Pro
Gly Glu 785 790 795 800 agg gca ctt gtc atc aac gga agg gtc gtt gga
ccg att gca gaa gac 2448Arg Ala Leu Val Ile Asn Gly Arg Val Val Gly
Pro Ile Ala Glu Asp 805 810 815 acc gcc ctg acc tca gag gac ctg gac
cag cta ctg ata tat gag aag 2496Thr Ala Leu Thr Ser Glu Asp Leu Asp
Gln Leu Leu Ile Tyr Glu Lys 820 825 830 caa aag cgg att act ccg gta
gca aag gcg gtc aaa gcc ctt gaa ttc 2544Gln Lys Arg Ile Thr Pro Val
Ala Lys Ala Val Lys Ala Leu Glu Phe 835 840 845 gac gag aag ctt tct
gat ccg cta gac ttt gcc aag ctt acc tcg ctc 2592Asp Glu Lys Leu Ser
Asp Pro Leu Asp Phe Ala Lys Leu Thr Ser Leu 850 855 860 acc acg ctg
tcc acg atc tcg gat gtg cca gag ggc ata tat gag tcg 2640Thr Thr Leu
Ser Thr Ile Ser Asp Val Pro Glu Gly Ile Tyr Glu Ser 865 870 875 880
act tcg gac att cgg ttg aat ttg ttc aac aga tgg aac gac tca caa
2688Thr Ser Asp Ile Arg Leu Asn Leu Phe Asn Arg Trp Asn Asp Ser Gln
885 890 895 tca gct atc act gtc tcc aat tcc gat gat cca gca att acc
att gta 2736Ser Ala Ile Thr Val Ser Asn Ser Asp Asp Pro Ala Ile Thr
Ile Val 900 905 910 gca tct atc gat ccg act tcg gaa gtt gct cag aag
tgg cta cca att 2784Ala Ser Ile Asp Pro Thr Ser Glu Val Ala Gln Lys
Trp Leu Pro Ile 915 920 925 cta aaa gta ctg tcg gag ctg gca agt gtc
aga gtg aga ttg gtc ctg 2832Leu Lys Val Leu Ser Glu Leu Ala Ser Val
Arg Val Arg Leu Val Leu 930 935 940 aac ccg cgc gag gag atc aaa gag
ctg ccc acc aag cgc ttc tat cgt 2880Asn Pro Arg Glu Glu Ile Lys Glu
Leu Pro Thr Lys Arg Phe Tyr Arg 945 950 955 960 tat gtt ctc gat tcg
gag cca tcg ttc aac gaa gat ggg tcg gtt tcc 2928Tyr Val Leu Asp Ser
Glu Pro Ser Phe Asn Glu Asp Gly Ser Val Ser 965 970 975 cgg ccc aca
gcc tcc ttc tcg ggc gtt ccc gtc gag gca ctc ctc acc 2976Arg Pro Thr
Ala Ser Phe Ser Gly Val Pro Val Glu Ala Leu Leu Thr 980 985 990 ctg
ggc atg gat gtt ccc tct tct tgg ctt gtg gct ccc aag gat tct 3024Leu
Gly Met Asp Val Pro Ser Ser Trp Leu Val Ala Pro Lys Asp Ser 995
1000 1005 atc cac gat ctt gac aat atc aag tta agt tcc gtc aag gac
ggc tcg 3072Ile His Asp Leu Asp Asn Ile Lys Leu Ser Ser Val Lys Asp
Gly Ser 1010 1015 1020 aat gtc gat gct att tac gca ttg gaa cac atc
ttg atc gag ggc cac 3120Asn Val Asp Ala Ile Tyr Ala Leu Glu His Ile
Leu Ile Glu Gly His 1025 1030 1035 1040tcc cgg gat atg acc acg aag
tcc cca cct aga gga gtt cag ctt gtc 3168Ser Arg Asp Met Thr Thr Lys
Ser Pro Pro Arg Gly Val Gln Leu Val 1045 1050 1055 ctt gga act gag
aac aac cct cac ttc tcg gat aca atc atc atg gcc 3216Leu Gly Thr Glu
Asn Asn Pro His Phe Ser Asp Thr Ile Ile Met Ala 1060 1065 1070 aat
ctc gga tac ttc caa ttc aaa gcc caa cct gga ctg tgg aac atc 3264Asn
Leu Gly Tyr Phe Gln Phe Lys Ala Gln Pro Gly Leu Trp Asn Ile 1075
1080 1085 aac ctc aaa ccg ggc cgt agc gaa cgc atc ttc acc ctc gac
agc gta 3312Asn Leu Lys Pro Gly Arg Ser Glu Arg Ile Phe Thr Leu Asp
Ser Val 1090 1095 1100 ggc agc ctc ggc tac aac ccc caa cct ggc gac
gaa aac aac gaa gtg 3360Gly Ser Leu Gly Tyr Asn Pro Gln Pro Gly Asp
Glu Asn Asn Glu Val 1105 1110 1115 1120gcc ctc ctc tcc ttc caa ggc
cgc acc ctt ttc ccg cgt gtc tcc cgt 3408Ala Leu Leu Ser Phe Gln Gly
Arg Thr Leu Phe Pro Arg Val Ser Arg 1125 1130 1135 aag aag ggc tac
gag acc gaa gac gtc ctc gag acc aac ccc aaa cca 3456Lys Lys Gly Tyr
Glu Thr Glu Asp Val Leu Glu Thr Asn Pro Lys Pro 1140 1145 1150 ggt
tct gcg atg gac tac atg aat aag ggg ttc aac ttc gcc tcc ggt 3504Gly
Ser Ala Met Asp Tyr Met Asn Lys Gly Phe Asn Phe Ala Ser Gly 1155
1160 1165 atc ctc tcc agc gtc gga gtc ggc acc aaa ggc agc act agc
ggc aaa 3552Ile Leu Ser Ser Val Gly Val Gly Thr Lys Gly Ser Thr Ser
Gly Lys 1170 1175 1180 cag gct gac att aac atc ttc tcc gtc gcc agt
gga cac ctc tac gag 3600Gln Ala Asp Ile Asn Ile Phe Ser Val Ala Ser
Gly His Leu Tyr Glu 1185 1190 1195 1200cgc atg ctc aac att atg atg
gtc tca gtg atg cgc aac acc aac cac 3648Arg Met Leu Asn Ile Met Met
Val Ser Val Met Arg Asn Thr Asn His 1205 1210 1215 agc gtg aaa ttc
tgg ttc atc gaa caa ttc ctc tcc ccg tcc ttc aag 3696Ser Val Lys Phe
Trp Phe Ile Glu Gln Phe Leu Ser Pro Ser Phe Lys 1220 1225 1230 tcc
ttc ctg cct cac ctt gcg aag gag tat aac ttc tct tac gaa atg 3744Ser
Phe Leu Pro His Leu Ala Lys Glu Tyr Asn Phe Ser Tyr Glu Met 1235
1240 1245 gtc acc tac aaa tgg cca cac tgg ctc cgg gcc cag aaa gaa
aag caa 3792Val Thr Tyr Lys Trp Pro His Trp Leu Arg Ala Gln Lys Glu
Lys Gln 1250 1255 1260 cgt gaa atc tgg ggc tac aag atc ctc ttc ctg
gac gtt ctc ttc cct 3840Arg Glu Ile Trp Gly Tyr Lys Ile Leu Phe Leu
Asp Val Leu Phe Pro 1265 1270 1275 1280ctc gac ctc gac aaa gtc atc
ttt gtc gac gcc gac cag ata gtc cgc 3888Leu Asp Leu Asp Lys Val Ile
Phe Val Asp Ala Asp Gln Ile Val Arg 1285 1290 1295 aca gat atg tac
gac ctc gtc agc ctt gac ctc gaa ggc gct ccg tac 3936Thr Asp Met Tyr
Asp Leu Val Ser Leu Asp Leu Glu Gly Ala Pro Tyr 1300 1305 1310 ggc
ttt act ccc atg tgc gac tcc cgc cac gag atg gaa ggc ttc cgc 3984Gly
Phe Thr Pro Met Cys Asp Ser Arg His Glu Met Glu Gly Phe Arg 1315
1320 1325 ttc tgg aag cag ggg tac tgg aag aac ttc ctc cgt ggt caa
ccc tac 4032Phe Trp Lys Gln Gly Tyr Trp Lys Asn Phe Leu Arg Gly Gln
Pro Tyr 1330 1335 1340 cat atc tcc gcg ctt tac gtt gtc gac ctg aac
cgc ttc cgt gcc atc 4080His Ile Ser Ala Leu Tyr Val Val Asp Leu Asn
Arg Phe Arg Ala Ile 1345 1350 1355 1360gcc gcc ggc gat cgc ctg cgt
gga cag tac cag atg ctg tca gct gac 4128Ala Ala Gly Asp Arg Leu Arg
Gly Gln Tyr Gln Met Leu Ser Ala Asp 1365 1370 1375 ccc gag agt ttg
agc aac ctg gac cag gat ctg ccg aac cac atg cag 4176Pro Glu Ser Leu
Ser Asn Leu Asp Gln Asp Leu Pro Asn His Met Gln 1380 1385 1390 cat
cat atc ccg atc aag agt ctg ccg cag gag tgg ctg tgg tgt gag 4224His
His Ile Pro Ile Lys Ser Leu Pro Gln Glu Trp Leu Trp Cys Glu 1395
1400 1405 act tgg tgc tcg gat gag tcg cag tca cag gct cgg acg atc
gac ctg 4272Thr Trp Cys Ser Asp Glu Ser Gln Ser Gln Ala Arg Thr Ile
Asp Leu 1410 1415 1420 tgc aat aac ccg atg acg aag gag ccg aag ttg
gat cgt gcc agg agg 4320Cys Asn Asn Pro Met Thr Lys Glu Pro Lys Leu
Asp Arg Ala Arg Arg 1425 1430 1435 1440cag gta cct gag tgg acg gag
tat gat gat gag att gcg gcc ttg tcg 4368Gln Val Pro Glu Trp Thr Glu
Tyr Asp Asp Glu Ile Ala Ala Leu Ser 1445 1450 1455 aag aga gtt gcc
gct gag aag cag cag ggg cag gtg gag gaa gaa agg 4416Lys Arg Val Ala
Ala Glu Lys Gln Gln Gly Gln Val Glu Glu Glu Arg 1460 1465 1470 gcc
ggt gaa tcg tac cct gac gag gat gag gag ggc gag act tcc tct 4464Ala
Gly Glu Ser Tyr Pro Asp Glu Asp Glu Glu Gly Glu Thr Ser Ser 1475
1480 1485 ggc tgg gat aag gat gag ctt tag 4488Gly Trp Asp Lys Asp
Glu Leu 1490 1495241495PRTAspergillus niger 24Met Val Ser Gly Leu
Ala Asn Phe Ala Ser
Trp Arg Leu Ala Ser Val 1 5 10 15 Leu Ile Ala Gly Leu Leu Ala Ile
Gln Gly Arg Ala Ser Pro Ser Val 20 25 30 Asn Val Ala Leu Gln Ala
Ser Phe Asp Ser Pro Pro Tyr Leu Ile Glu 35 40 45 Leu Leu Glu Ser
Ala Ala Glu Glu Asn Ser Thr Ser Tyr Phe Pro Leu 50 55 60 Leu Asp
Arg Ile Ala Asp Gly Ile Phe Asp Asp Ala Val Thr Asp Lys 65 70 75 80
Asp Leu Tyr Asp Arg Phe Leu Glu Val Val Arg Glu Asp Gly His Leu 85
90 95 Arg Thr Pro Glu Ser Leu Ser Ser Phe Lys Leu Ser Leu Ala Met
Arg 100 105 110 Ser Ala Ser Pro Arg Ile Thr Ala His Tyr Gln Tyr Tyr
Asn Ala Ser 115 120 125 Val Gln Tyr Ser Leu Met Ala Ala Gln Asp Ala
Val Cys Pro Val Trp 130 135 140 Val His Ser Glu Gly Lys Gln Tyr Cys
Ser Ser Thr Met Glu Arg Ala 145 150 155 160 Gln Gln Asp Val Thr Gly
Ser Asp Asp Pro Arg Glu Leu Pro Phe Asp 165 170 175 Arg Val Phe Gly
Asp Pro Ser Leu Pro Pro Ala Ile Leu Tyr Ala Asp 180 185 190 Ile Ala
Ser Pro Met Phe Lys Glu Phe His Gln Ser Leu Ser Thr Met 195 200 205
Ala Lys Glu Gly Gln Val Ser Tyr Arg Val Arg Tyr Arg Pro Pro Gln 210
215 220 His Trp Ser Pro Arg Pro Val Phe Val Ser Gly Tyr Gly Val Glu
Leu 225 230 235 240 Ala Leu Lys Arg Thr Asp Tyr Ile Val Ile Asp Asp
Arg Asp Ala Glu 245 250 255 Glu Arg Gly Thr Gly Ser Ile Glu Ser Gly
Lys Ser Asp Glu Thr Glu 260 265 270 Asp Asp Leu Asp Asp Leu Arg Pro
Leu Ser Ser Ser Glu Val Ser Arg 275 280 285 Leu Gly Leu Asn Thr Val
Gly Tyr Val Leu Asp Ser Asp Asp Pro Phe 290 295 300 Asp Thr Leu Val
Lys Leu Ser Gln Asp Phe Pro Lys Tyr Ser Ala Arg 305 310 315 320 Val
Ala Ala His Asn Val Ser Thr Glu Leu Leu Gln Asp Val Arg Ser 325 330
335 Ser Arg Leu Arg Met Leu Pro Pro Gly Leu Asn Val Leu Trp Ile Asn
340 345 350 Gly Val Gln Ile Glu Pro Arg Gln Val Asp Ala Phe Thr Leu
Leu Asp 355 360 365 His Leu Arg Arg Glu Arg Lys Leu Ile Glu Lys Phe
Arg Asn Leu Gly 370 375 380 Leu Ser Ala Thr Asp Ala Val Glu Leu Leu
Ser His Pro Leu Leu Gly 385 390 395 400 Glu Ala Leu Ala Arg Asp Gly
Pro Gln Arg Tyr Asn Tyr Arg Asp Asp 405 410 415 Ile Glu Gly Gly Gly
Val Ile Met Trp Leu Asn Asn Leu Glu Lys Asp 420 425 430 Ala Arg Tyr
Glu Ser Trp Pro Ser Glu Leu Ala Gly Phe Met Gln Arg 435 440 445 Thr
Tyr Pro Gly Gln Leu Pro Ala Val Arg Arg Asp Ser Asn Asn Ile 450 455
460 Val Phe Pro Val Asp Leu Thr Ser Thr Glu Asp Ala Asp Ile Val Val
465 470 475 480 Lys Thr Ile Gln Val Phe Val Lys Asn Lys Ile Pro Val
Arg Phe Gly 485 490 495 Leu Ile Pro Val Thr Phe Ser Asp Gly Ala Ile
Ala Gln Leu Lys Val 500 505 510 Ala His Tyr Leu Gln Glu Thr Phe Gly
Leu Ala Ser Phe Met Asp Tyr 515 520 525 Leu Glu Ala Ser Ala Ser Lys
Asn Lys Leu Ala Ser Pro Asp Lys Ala 530 535 540 Cys Phe Gln Ala Ala
Thr Gln Asp Arg Ser Pro Arg Leu Glu Lys Val 545 550 555 560 Ser Leu
Ser Leu Asp Glu Val Leu Asn Asn Ala Val Tyr Asp Ala Thr 565 570 575
Val Ser Lys Thr Thr Ala Tyr Leu Asn Arg Leu Gly Met Lys His Glu 580
585 590 Pro Ser His Ala Phe Val Asn Gly Ile Pro Val Thr Arg Asn Asp
Lys 595 600 605 Trp Ala Gln Glu Met Ser Thr Lys Ile Ser Lys Asp Thr
Gln Leu Ile 610 615 620 Gln Gln Lys Ile Ala Asp Ala Glu Val Asp Glu
Asp Thr Trp Leu Pro 625 630 635 640 Glu Leu Phe Leu Ser Gln Ala Phe
Asp Arg Arg Asn Pro Ala Ile Val 645 650 655 Pro Glu Asp Pro Lys Glu
Ile Arg Ala Val Asp Leu Val Gln Leu Ala 660 665 670 Asp Ser Gln Glu
Lys Leu Phe Ser Gln Ile Pro Arg Leu Gly Leu Asp 675 680 685 Glu Ser
Asn Ala Leu Glu Ser Ala His Ala Ile Val Val Gly Asn Phe 690 695 700
Asp Glu Lys Ser Gly Tyr Glu Leu Leu Ser Ala Ala Leu Glu Ser Arg 705
710 715 720 Lys Thr His Gly Glu Val Glu Met Leu Phe Leu His Asn Pro
Lys Leu 725 730 735 Glu Ala Ser Pro Ala Ser Arg Ser Val Ala Val Arg
Arg Leu Leu Asn 740 745 750 Gly Gly Lys Glu Val Asp Ala Ser Gln Ile
Leu Glu Ala Ile Ala Ser 755 760 765 Ser Ala Ser Pro Ala Asp Glu Glu
Ala Gly Asp Ala Ala Leu Phe Trp 770 775 780 Glu Ala Gln Arg Ala Val
Val Glu Glu Leu Gly Leu Ala Pro Gly Glu 785 790 795 800 Arg Ala Leu
Val Ile Asn Gly Arg Val Val Gly Pro Ile Ala Glu Asp 805 810 815 Thr
Ala Leu Thr Ser Glu Asp Leu Asp Gln Leu Leu Ile Tyr Glu Lys 820 825
830 Gln Lys Arg Ile Thr Pro Val Ala Lys Ala Val Lys Ala Leu Glu Phe
835 840 845 Asp Glu Lys Leu Ser Asp Pro Leu Asp Phe Ala Lys Leu Thr
Ser Leu 850 855 860 Thr Thr Leu Ser Thr Ile Ser Asp Val Pro Glu Gly
Ile Tyr Glu Ser 865 870 875 880 Thr Ser Asp Ile Arg Leu Asn Leu Phe
Asn Arg Trp Asn Asp Ser Gln 885 890 895 Ser Ala Ile Thr Val Ser Asn
Ser Asp Asp Pro Ala Ile Thr Ile Val 900 905 910 Ala Ser Ile Asp Pro
Thr Ser Glu Val Ala Gln Lys Trp Leu Pro Ile 915 920 925 Leu Lys Val
Leu Ser Glu Leu Ala Ser Val Arg Val Arg Leu Val Leu 930 935 940 Asn
Pro Arg Glu Glu Ile Lys Glu Leu Pro Thr Lys Arg Phe Tyr Arg 945 950
955 960 Tyr Val Leu Asp Ser Glu Pro Ser Phe Asn Glu Asp Gly Ser Val
Ser 965 970 975 Arg Pro Thr Ala Ser Phe Ser Gly Val Pro Val Glu Ala
Leu Leu Thr 980 985 990 Leu Gly Met Asp Val Pro Ser Ser Trp Leu Val
Ala Pro Lys Asp Ser 995 1000 1005 Ile His Asp Leu Asp Asn Ile Lys
Leu Ser Ser Val Lys Asp Gly Ser 1010 1015 1020 Asn Val Asp Ala Ile
Tyr Ala Leu Glu His Ile Leu Ile Glu Gly His 1025 1030 1035 1040Ser
Arg Asp Met Thr Thr Lys Ser Pro Pro Arg Gly Val Gln Leu Val 1045
1050 1055 Leu Gly Thr Glu Asn Asn Pro His Phe Ser Asp Thr Ile Ile
Met Ala 1060 1065 1070 Asn Leu Gly Tyr Phe Gln Phe Lys Ala Gln Pro
Gly Leu Trp Asn Ile 1075 1080 1085 Asn Leu Lys Pro Gly Arg Ser Glu
Arg Ile Phe Thr Leu Asp Ser Val 1090 1095 1100 Gly Ser Leu Gly Tyr
Asn Pro Gln Pro Gly Asp Glu Asn Asn Glu Val 1105 1110 1115 1120Ala
Leu Leu Ser Phe Gln Gly Arg Thr Leu Phe Pro Arg Val Ser Arg 1125
1130 1135 Lys Lys Gly Tyr Glu Thr Glu Asp Val Leu Glu Thr Asn Pro
Lys Pro 1140 1145 1150 Gly Ser Ala Met Asp Tyr Met Asn Lys Gly Phe
Asn Phe Ala Ser Gly 1155 1160 1165 Ile Leu Ser Ser Val Gly Val Gly
Thr Lys Gly Ser Thr Ser Gly Lys 1170 1175 1180 Gln Ala Asp Ile Asn
Ile Phe Ser Val Ala Ser Gly His Leu Tyr Glu 1185 1190 1195 1200Arg
Met Leu Asn Ile Met Met Val Ser Val Met Arg Asn Thr Asn His 1205
1210 1215 Ser Val Lys Phe Trp Phe Ile Glu Gln Phe Leu Ser Pro Ser
Phe Lys 1220 1225 1230 Ser Phe Leu Pro His Leu Ala Lys Glu Tyr Asn
Phe Ser Tyr Glu Met 1235 1240 1245 Val Thr Tyr Lys Trp Pro His Trp
Leu Arg Ala Gln Lys Glu Lys Gln 1250 1255 1260 Arg Glu Ile Trp Gly
Tyr Lys Ile Leu Phe Leu Asp Val Leu Phe Pro 1265 1270 1275 1280Leu
Asp Leu Asp Lys Val Ile Phe Val Asp Ala Asp Gln Ile Val Arg 1285
1290 1295 Thr Asp Met Tyr Asp Leu Val Ser Leu Asp Leu Glu Gly Ala
Pro Tyr 1300 1305 1310 Gly Phe Thr Pro Met Cys Asp Ser Arg His Glu
Met Glu Gly Phe Arg 1315 1320 1325 Phe Trp Lys Gln Gly Tyr Trp Lys
Asn Phe Leu Arg Gly Gln Pro Tyr 1330 1335 1340 His Ile Ser Ala Leu
Tyr Val Val Asp Leu Asn Arg Phe Arg Ala Ile 1345 1350 1355 1360Ala
Ala Gly Asp Arg Leu Arg Gly Gln Tyr Gln Met Leu Ser Ala Asp 1365
1370 1375 Pro Glu Ser Leu Ser Asn Leu Asp Gln Asp Leu Pro Asn His
Met Gln 1380 1385 1390 His His Ile Pro Ile Lys Ser Leu Pro Gln Glu
Trp Leu Trp Cys Glu 1395 1400 1405 Thr Trp Cys Ser Asp Glu Ser Gln
Ser Gln Ala Arg Thr Ile Asp Leu 1410 1415 1420 Cys Asn Asn Pro Met
Thr Lys Glu Pro Lys Leu Asp Arg Ala Arg Arg 1425 1430 1435 1440Gln
Val Pro Glu Trp Thr Glu Tyr Asp Asp Glu Ile Ala Ala Leu Ser 1445
1450 1455 Lys Arg Val Ala Ala Glu Lys Gln Gln Gly Gln Val Glu Glu
Glu Arg 1460 1465 1470 Ala Gly Glu Ser Tyr Pro Asp Glu Asp Glu Glu
Gly Glu Thr Ser Ser 1475 1480 1485 Gly Trp Asp Lys Asp Glu Leu 1490
1495251531DNAAspergillus niger 25attgtcatac agtggccgac aacctacgtt
acccgaccgg gtctctgggt tgattaactg 60agcacggtcc acacgaggac cattgaggac
catctctcgc gaacttactg ggctatcttg 120atggtactct agaagtgggt
tgcaggacaa ttccacagtg aaagctgcgt gtcaagcttt 180ctatatatac
actattgacc atgctgaacc tcaatatctt ccggctactg gccgatctct
240cccatatctc ctccaaatgt gtcttgatat gggctatcca tcgcaataag
agcgcagaag 300gtccgtataa taacttgcat tgttgcagtg tgctgcgagc
taagcatcgt ttcaaataat 360aggagtctcc cttctgacgc agatgctcta
tgctttggtg ttcgtgactc gttatctcga 420ccttttctcg aaggcaggat
ggaagcactt ctacctcgta ttcttcaagc tattttatat 480catctcctcg
ttctacgtta tatacctgat gatgagagta tttccccgga cacgggaaag
540ggagcgagcc tggaagatgg ctataatatc ggtcgctcta tctctggttc
tggctcctat 600atctattgtc atcttctatc gtggttatcc cgatagatgg
ttcacggagg taagtgggat 660ggctcgcatt ggcctgcaga cgtcgctaac
caaaccgtga tgatatgcag acttgctgga 720ctttctcgat tatattagag
tccgtctgtg ttctccctca attgttgctc ttgcgccaaa 780cgaccgttcc
gacagtcatc gattcatact acctgcttat gctgggatcc taccgtgcct
840tctatattct caattggctt gtgcggggac tgggctctga gggtcattgg
gacgtaattg 900cagacctcta cggtgtcatc cagacggctt tctacgtcga
tttcgcctgg gtttactact 960cccgccaacg cgtgaagctc cgaaacggcg
gtgtcgttga ctcggaagat ttccgccata 1020gctggctagt gagcaagata
ctgaatttcc ggcagcgaag gagtgcagat gaggagcaga 1080atttgaacga
cgaggacgtg gaggatgagg aagttgctgg tggcggtaga cccaggaaca
1140accgctgggg agcaatgggg atctccgtct cggccgacga tacgctagga
aaccatcgtg 1200ggacaagcca agacgagagt ctggaagggt tcttagaaga
tgaagaagac gacgaggaca 1260ataacgggta ccctgtgaac gggggcgttc
gtccgaagca gtcaaccggg gtaacgggca 1320gtcacgaatg aactatctgc
ccttaaaccc catatataga aatcctgctg cagatcagcc 1380ggttttggtt
acacgattca actgccctcg gggcattata tacatcccta gggctcgttc
1440tccccctttc gcttccttca tggtctgttt ctttattgct cgggtctttg
tttgcatgga 1500tttctctcac gtcatcaagt tttcacaatc t
1531261008DNAAspergillus nigerCDS(1)..(1008) 26atg ctg aac ctc aat
atc ttc cgg cta ctg gcc gat ctc tcc cat atc 48Met Leu Asn Leu Asn
Ile Phe Arg Leu Leu Ala Asp Leu Ser His Ile 1 5 10 15 tcc tcc aaa
tgt gtc ttg ata tgg gct atc cat cgc aat aag agc gca 96Ser Ser Lys
Cys Val Leu Ile Trp Ala Ile His Arg Asn Lys Ser Ala 20 25 30 gaa
gga gtc tcc ctt ctg acg cag atg ctc tat gct ttg gtg ttc gtg 144Glu
Gly Val Ser Leu Leu Thr Gln Met Leu Tyr Ala Leu Val Phe Val 35 40
45 act cgt tat ctc gac ctt ttc tcg aag gca gga tgg aag cac ttc tac
192Thr Arg Tyr Leu Asp Leu Phe Ser Lys Ala Gly Trp Lys His Phe Tyr
50 55 60 ctc gta ttc ttc aag cta ttt tat atc atc tcc tcg ttc tac
gtt ata 240Leu Val Phe Phe Lys Leu Phe Tyr Ile Ile Ser Ser Phe Tyr
Val Ile 65 70 75 80 tac ctg atg atg aga gta ttt ccc cgg aca cgg gaa
agg gag cga gcc 288Tyr Leu Met Met Arg Val Phe Pro Arg Thr Arg Glu
Arg Glu Arg Ala 85 90 95 tgg aag atg gct ata ata tcg gtc gct cta
tct ctg gtt ctg gct cct 336Trp Lys Met Ala Ile Ile Ser Val Ala Leu
Ser Leu Val Leu Ala Pro 100 105 110 ata tct att gtc atc ttc tat cgt
ggt tat ccc gat aga tgg ttc acg 384Ile Ser Ile Val Ile Phe Tyr Arg
Gly Tyr Pro Asp Arg Trp Phe Thr 115 120 125 gag act tgc tgg act ttc
tcg att ata tta gag tcc gtc tgt gtt ctc 432Glu Thr Cys Trp Thr Phe
Ser Ile Ile Leu Glu Ser Val Cys Val Leu 130 135 140 cct caa ttg ttg
ctc ttg cgc caa acg acc gtt ccg aca gtc atc gat 480Pro Gln Leu Leu
Leu Leu Arg Gln Thr Thr Val Pro Thr Val Ile Asp 145 150 155 160 tca
tac tac ctg ctt atg ctg gga tcc tac cgt gcc ttc tat att ctc 528Ser
Tyr Tyr Leu Leu Met Leu Gly Ser Tyr Arg Ala Phe Tyr Ile Leu 165 170
175 aat tgg ctt gtg cgg gga ctg ggc tct gag ggt cat tgg gac gta att
576Asn Trp Leu Val Arg Gly Leu Gly Ser Glu Gly His Trp Asp Val Ile
180 185 190 gca gac ctc tac ggt gtc atc cag acg gct ttc tac gtc gat
ttc gcc 624Ala Asp Leu Tyr Gly Val Ile Gln Thr Ala Phe Tyr Val Asp
Phe Ala 195 200 205 tgg gtt tac tac tcc cgc caa cgc gtg aag ctc cga
aac ggc ggt gtc 672Trp Val Tyr Tyr Ser Arg Gln Arg Val Lys Leu Arg
Asn Gly Gly Val 210 215 220 gtt gac tcg gaa gat ttc cgc cat agc tgg
cta gtg agc aag ata ctg 720Val Asp Ser Glu Asp Phe Arg His Ser Trp
Leu Val Ser Lys Ile Leu 225 230 235 240 aat ttc cgg cag cga agg agt
gca gat gag gag cag aat ttg aac gac 768Asn Phe Arg Gln Arg Arg Ser
Ala Asp Glu Glu Gln Asn Leu Asn Asp 245 250 255 gag gac gtg gag gat
gag gaa gtt gct ggt ggc ggt aga ccc agg aac 816Glu Asp Val Glu Asp
Glu Glu Val Ala Gly Gly Gly Arg Pro Arg Asn 260 265 270 aac cgc tgg
gga gca atg ggg atc tcc gtc tcg gcc gac gat acg cta 864Asn Arg Trp
Gly Ala Met Gly Ile Ser Val Ser Ala Asp Asp Thr Leu 275 280 285 gga
aac cat cgt ggg aca agc caa gac gag agt ctg gaa ggg ttc tta 912Gly
Asn His Arg Gly Thr Ser Gln Asp Glu Ser Leu Glu Gly Phe Leu 290 295
300 gaa gat gaa gaa gac gac gag gac aat aac ggg tac cct gtg aac ggg
960Glu Asp Glu Glu Asp Asp Glu Asp Asn Asn Gly Tyr Pro Val Asn Gly
305 310 315 320 ggc gtt cgt ccg aag cag tca acc ggg gta acg ggc agt
cac gaa tga 1008Gly Val Arg Pro Lys Gln Ser Thr Gly Val Thr Gly Ser
His Glu 325 330 335 27335PRTAspergillus niger 27Met Leu Asn Leu Asn
Ile Phe Arg Leu Leu Ala Asp Leu Ser His Ile 1 5 10 15 Ser Ser Lys
Cys Val Leu Ile Trp Ala Ile His Arg Asn Lys Ser Ala 20 25 30
Glu
Gly Val Ser Leu Leu Thr Gln Met Leu Tyr Ala Leu Val Phe Val 35 40
45 Thr Arg Tyr Leu Asp Leu Phe Ser Lys Ala Gly Trp Lys His Phe Tyr
50 55 60 Leu Val Phe Phe Lys Leu Phe Tyr Ile Ile Ser Ser Phe Tyr
Val Ile 65 70 75 80 Tyr Leu Met Met Arg Val Phe Pro Arg Thr Arg Glu
Arg Glu Arg Ala 85 90 95 Trp Lys Met Ala Ile Ile Ser Val Ala Leu
Ser Leu Val Leu Ala Pro 100 105 110 Ile Ser Ile Val Ile Phe Tyr Arg
Gly Tyr Pro Asp Arg Trp Phe Thr 115 120 125 Glu Thr Cys Trp Thr Phe
Ser Ile Ile Leu Glu Ser Val Cys Val Leu 130 135 140 Pro Gln Leu Leu
Leu Leu Arg Gln Thr Thr Val Pro Thr Val Ile Asp 145 150 155 160 Ser
Tyr Tyr Leu Leu Met Leu Gly Ser Tyr Arg Ala Phe Tyr Ile Leu 165 170
175 Asn Trp Leu Val Arg Gly Leu Gly Ser Glu Gly His Trp Asp Val Ile
180 185 190 Ala Asp Leu Tyr Gly Val Ile Gln Thr Ala Phe Tyr Val Asp
Phe Ala 195 200 205 Trp Val Tyr Tyr Ser Arg Gln Arg Val Lys Leu Arg
Asn Gly Gly Val 210 215 220 Val Asp Ser Glu Asp Phe Arg His Ser Trp
Leu Val Ser Lys Ile Leu 225 230 235 240 Asn Phe Arg Gln Arg Arg Ser
Ala Asp Glu Glu Gln Asn Leu Asn Asp 245 250 255 Glu Asp Val Glu Asp
Glu Glu Val Ala Gly Gly Gly Arg Pro Arg Asn 260 265 270 Asn Arg Trp
Gly Ala Met Gly Ile Ser Val Ser Ala Asp Asp Thr Leu 275 280 285 Gly
Asn His Arg Gly Thr Ser Gln Asp Glu Ser Leu Glu Gly Phe Leu 290 295
300 Glu Asp Glu Glu Asp Asp Glu Asp Asn Asn Gly Tyr Pro Val Asn Gly
305 310 315 320 Gly Val Arg Pro Lys Gln Ser Thr Gly Val Thr Gly Ser
His Glu 325 330 335 283392DNAAspergillus niger 28gcccttgttg
tactactttc attatcgtat ctagttgcat tttccttctt ctatcccagc 60acataacagc
tttgtgtgtg ggaccttcac ctctggtaga tgcaggtcga cacactagtg
120gttgctgata gttcttcttt cagaggttga gtgtctctga ttgactactg
agctctccca 180tcatggccgg aactcggcca atgtccaacc gttggaccct
actgctgtcc ttggtgatcc 240tactcggatg ccttgtcatc cccggaggta
agcctatcca atcacactcc tactggtgag 300gctctccttg acatctaaca
atgacgcata gtcaccgtga aacacgagaa cttcaagaca 360tgttctcaat
cgggcttctg taagcggaac agagcattcg ccgacgatgc tgccgcccaa
420ggttcctcct gggcctcccc atacgaactc gactcatcct ccatccagtt
caaggatggc 480caattgcacg gaaccattct caagtccgtc tcccccaacg
agaaagtcaa gctgcctctc 540gttgtctcct tcctcgagtc cggcgccgcc
cgagttgttg tcgatgagga aaagcgcatg 600aacggtgaca tccagcttcg
acacgatagc aaagcacgca aggaacgcta caatgaggca 660gagaaatggg
tgttggttgg tggcctggag ttgagcaaaa ccgcgacctt gagacctgaa
720accgagtctg gctttaccag agtcttgtac ggtccggaca accagttcga
ggctgtcatc 780cgccacgccc cctttagcgc cgacttcaag agggatggcc
aaacccacgt tcaattgaac 840aacaagggct accttaacat ggagcattgg
cgccctaagg tagaggtcga aggcgagggc 900gagcagcaaa cccaggaaga
tgaaagcact tggtgggatg agagctttgg tggaaacacg 960gacaccaagc
ccaggggtcc cgagagtgtg ggattggata tcaccttccc tggctacaag
1020catgtttttg gaattcctga gcatgctgac tctctctcct taaaggaaac
tcggtaagct 1080agtcgcgcag tgacattttc catctcgcag aactgacagc
gtcccagagg tggtgaaggg 1140aatcacgaag agccctaccg catgtacaat
gcggatgtat ttgagtacga gctgagcagt 1200cccatgacct tgtatggtgc
tattccattc atgcaggcac atcgcaagga ctccaccgtc 1260ggtgtcttct
ggctgaatgc tgcagagacc tgggtggaca ttgtcaagtc tacctcatct
1320cctaaccctc ttgctctcgg cgtgggcgcc accactgaca cccagagtca
ttggttttcg 1380gagtccggcc agctcgacgt gttcgttttc cttggtccta
ccccacagga aatcagcaag 1440acctatggtg aactcaccgg ctacactcag
ttgcctcaac attttgccat tgcttatcac 1500cagtgccgct ggaactacat
cactgatgag gatgtcaagg aggtcgatcg caactttgac 1560aagtaccaga
tcccctacga tgtcatctgg ctggacatcg aatataccga tgacagaaag
1620tatttcacct gggatccact cagtttcccc gatccgatca gcatggagga
gcagctcgat 1680gagtcggagc gcaaactcgt cgttatcatt gacccgcaca
tcaagaacca ggacaagtac 1740agcatcgtcc aagaaatgaa gagcaaagac
ttggccacta agaacaagga cggtgagatc 1800tacgacgggt ggtgttggcc
tggctcttct cactggatcg ataccttcaa ccccgccgcc 1860atcaaatggt
gggtcagctt attcaagttt gacaagttca aggggacgct gtccaatgtc
1920ttcatttgga acgacatgaa cgagccctcg gttttcaacg gtcccgaaac
cacgatgccc 1980aaggataacc ttcatcatgg caactgggag caccgtgaca
tccataacgt tcatggaatc 2040accctggtca atgccaccta cgatgccctt
ctagagcgca agaagggcga gatccgtcgg 2100cctttcattc tgacacggtc
atattatgct ggtgctcaac ggatgtctgc tatgtggacg 2160ggtgataacc
aggctacttg ggaacacttg gccgcttcca tccctatggt tctgaacaac
2220ggcattgcgg gcttcccctt tgccggtgct gacgtgggcg gtttcttcca
gaaccctagc 2280aaggagctct tgaccagatg gtaccaagct ggtatttggt
accccttctt ccgggcccac 2340gcgcatattg acacgcgccg gagagagccg
tatctgattg ccgagccaca ccggtctatc 2400atctcccagg ctatccgcct
gaggtatcag cttctccccg cctggtacac tgccttccac 2460gaagcttccg
tgaacggaat gccgatcgtg aggccgcagt actacgctca cccttgggat
2520gaggctggct ttgccattga cgaccagctt tatctcggct ccaccggtct
tcttgctaag 2580cctgttgtct ccgaggaggc caccacggcc gacatttacc
ttgctgacga cgaaaagtac 2640tatgactact ttgactacac cgtctaccag
ggagccggaa agcggcatac ggtgcctgct 2700cctatggaga ctgtgccatt
gctgatgcag ggtggccatg taatcccccg caaggaccgt 2760cctcgccgca
gtagcgcctt gatgagatgg gatccgtaca ctcttgttgt ggtcttggat
2820aagaacggtc aagccgatgg ctctctctac gtggatgacg gtgagacgtt
cgactatgag 2880cgtggagctt atatccaccg ccgtttccgc ttccaggagt
ctgccctggt ctcggaggat 2940gttggcacca agggtcctaa gacggccgag
tacttgaaga ccatggccaa cgttcgtgtt 3000gagcgggtgg tggtagttga
tcctcctaag gaatggcagg gtaagaccag tgtgactgtc 3060attgaggatg
gagcttcggc ggcttcgaca gcctctatgc agtaccacag ccagcccgat
3120ggcaaggccg catatgcggt ggtgaagaac cccaatgtcg gcattggaaa
gacatggcgg 3180attgagtttt agactagacg aggatatgga ttgagcaccc
atacatatat gcaagaggct 3240catatatcaa acatcaatgg tatttagtta
tgacgctttc agatgccctt acaccctagt 3300tgagcaccac ccgtagtaga
atcgtagtga agggtggaac cccaaccctg aagaggaaaa 3360agggaaggca
actcccggag tggggctgag tc 3392292874DNAAspergillus
nigerCDS(1)..(2874) 29atg tcc aac cgt tgg acc cta ctg ctg tcc ttg
gtg atc cta ctc gga 48Met Ser Asn Arg Trp Thr Leu Leu Leu Ser Leu
Val Ile Leu Leu Gly 1 5 10 15 tgc ctt gtc atc ccc gga gtc acc gtg
aaa cac gag aac ttc aag aca 96Cys Leu Val Ile Pro Gly Val Thr Val
Lys His Glu Asn Phe Lys Thr 20 25 30 tgt tct caa tcg ggc ttc tgt
aag cgg aac aga gca ttc gcc gac gat 144Cys Ser Gln Ser Gly Phe Cys
Lys Arg Asn Arg Ala Phe Ala Asp Asp 35 40 45 gct gcc gcc caa ggt
tcc tcc tgg gcc tcc cca tac gaa ctc gac tca 192Ala Ala Ala Gln Gly
Ser Ser Trp Ala Ser Pro Tyr Glu Leu Asp Ser 50 55 60 tcc tcc atc
cag ttc aag gat ggc caa ttg cac gga acc att ctc aag 240Ser Ser Ile
Gln Phe Lys Asp Gly Gln Leu His Gly Thr Ile Leu Lys 65 70 75 80 tcc
gtc tcc ccc aac gag aaa gtc aag ctg cct ctc gtt gtc tcc ttc 288Ser
Val Ser Pro Asn Glu Lys Val Lys Leu Pro Leu Val Val Ser Phe 85 90
95 ctc gag tcc ggc gcc gcc cga gtt gtt gtc gat gag gaa aag cgc atg
336Leu Glu Ser Gly Ala Ala Arg Val Val Val Asp Glu Glu Lys Arg Met
100 105 110 aac ggt gac atc cag ctt cga cac gat agc aaa gca cgc aag
gaa cgc 384Asn Gly Asp Ile Gln Leu Arg His Asp Ser Lys Ala Arg Lys
Glu Arg 115 120 125 tac aat gag gca gag aaa tgg gtg ttg gtt ggt ggc
ctg gag ttg agc 432Tyr Asn Glu Ala Glu Lys Trp Val Leu Val Gly Gly
Leu Glu Leu Ser 130 135 140 aaa acc gcg acc ttg aga cct gaa acc gag
tct ggc ttt acc aga gtc 480Lys Thr Ala Thr Leu Arg Pro Glu Thr Glu
Ser Gly Phe Thr Arg Val 145 150 155 160 ttg tac ggt ccg gac aac cag
ttc gag gct gtc atc cgc cac gcc ccc 528Leu Tyr Gly Pro Asp Asn Gln
Phe Glu Ala Val Ile Arg His Ala Pro 165 170 175 ttt agc gcc gac ttc
aag agg gat ggc caa acc cac gtt caa ttg aac 576Phe Ser Ala Asp Phe
Lys Arg Asp Gly Gln Thr His Val Gln Leu Asn 180 185 190 aac aag ggc
tac ctt aac atg gag cat tgg cgc cct aag gta gag gtc 624Asn Lys Gly
Tyr Leu Asn Met Glu His Trp Arg Pro Lys Val Glu Val 195 200 205 gaa
ggc gag ggc gag cag caa acc cag gaa gat gaa agc act tgg tgg 672Glu
Gly Glu Gly Glu Gln Gln Thr Gln Glu Asp Glu Ser Thr Trp Trp 210 215
220 gat gag agc ttt ggt gga aac acg gac acc aag ccc agg ggt ccc gag
720Asp Glu Ser Phe Gly Gly Asn Thr Asp Thr Lys Pro Arg Gly Pro Glu
225 230 235 240 agt gtg gga ttg gat atc acc ttc cct ggc tac aag cat
gtt ttt gga 768Ser Val Gly Leu Asp Ile Thr Phe Pro Gly Tyr Lys His
Val Phe Gly 245 250 255 att cct gag cat gct gac tct ctc tcc tta aag
gaa act cga ggt ggt 816Ile Pro Glu His Ala Asp Ser Leu Ser Leu Lys
Glu Thr Arg Gly Gly 260 265 270 gaa ggg aat cac gaa gag ccc tac cgc
atg tac aat gcg gat gta ttt 864Glu Gly Asn His Glu Glu Pro Tyr Arg
Met Tyr Asn Ala Asp Val Phe 275 280 285 gag tac gag ctg agc agt ccc
atg acc ttg tat ggt gct att cca ttc 912Glu Tyr Glu Leu Ser Ser Pro
Met Thr Leu Tyr Gly Ala Ile Pro Phe 290 295 300 atg cag gca cat cgc
aag gac tcc acc gtc ggt gtc ttc tgg ctg aat 960Met Gln Ala His Arg
Lys Asp Ser Thr Val Gly Val Phe Trp Leu Asn 305 310 315 320 gct gca
gag acc tgg gtg gac att gtc aag tct acc tca tct cct aac 1008Ala Ala
Glu Thr Trp Val Asp Ile Val Lys Ser Thr Ser Ser Pro Asn 325 330 335
cct ctt gct ctc ggc gtg ggc gcc acc act gac acc cag agt cat tgg
1056Pro Leu Ala Leu Gly Val Gly Ala Thr Thr Asp Thr Gln Ser His Trp
340 345 350 ttt tcg gag tcc ggc cag ctc gac gtg ttc gtt ttc ctt ggt
cct acc 1104Phe Ser Glu Ser Gly Gln Leu Asp Val Phe Val Phe Leu Gly
Pro Thr 355 360 365 cca cag gaa atc agc aag acc tat ggt gaa ctc acc
ggc tac act cag 1152Pro Gln Glu Ile Ser Lys Thr Tyr Gly Glu Leu Thr
Gly Tyr Thr Gln 370 375 380 ttg cct caa cat ttt gcc att gct tat cac
cag tgc cgc tgg aac tac 1200Leu Pro Gln His Phe Ala Ile Ala Tyr His
Gln Cys Arg Trp Asn Tyr 385 390 395 400 atc act gat gag gat gtc aag
gag gtc gat cgc aac ttt gac aag tac 1248Ile Thr Asp Glu Asp Val Lys
Glu Val Asp Arg Asn Phe Asp Lys Tyr 405 410 415 cag atc ccc tac gat
gtc atc tgg ctg gac atc gaa tat acc gat gac 1296Gln Ile Pro Tyr Asp
Val Ile Trp Leu Asp Ile Glu Tyr Thr Asp Asp 420 425 430 aga aag tat
ttc acc tgg gat cca ctc agt ttc ccc gat ccg atc agc 1344Arg Lys Tyr
Phe Thr Trp Asp Pro Leu Ser Phe Pro Asp Pro Ile Ser 435 440 445 atg
gag gag cag ctc gat gag tcg gag cgc aaa ctc gtc gtt atc att 1392Met
Glu Glu Gln Leu Asp Glu Ser Glu Arg Lys Leu Val Val Ile Ile 450 455
460 gac ccg cac atc aag aac cag gac aag tac agc atc gtc caa gaa atg
1440Asp Pro His Ile Lys Asn Gln Asp Lys Tyr Ser Ile Val Gln Glu Met
465 470 475 480 aag agc aaa gac ttg gcc act aag aac aag gac ggt gag
atc tac gac 1488Lys Ser Lys Asp Leu Ala Thr Lys Asn Lys Asp Gly Glu
Ile Tyr Asp 485 490 495 ggg tgg tgt tgg cct ggc tct tct cac tgg atc
gat acc ttc aac ccc 1536Gly Trp Cys Trp Pro Gly Ser Ser His Trp Ile
Asp Thr Phe Asn Pro 500 505 510 gcc gcc atc aaa tgg tgg gtc agc tta
ttc aag ttt gac aag ttc aag 1584Ala Ala Ile Lys Trp Trp Val Ser Leu
Phe Lys Phe Asp Lys Phe Lys 515 520 525 ggg acg ctg tcc aat gtc ttc
att tgg aac gac atg aac gag ccc tcg 1632Gly Thr Leu Ser Asn Val Phe
Ile Trp Asn Asp Met Asn Glu Pro Ser 530 535 540 gtt ttc aac ggt ccc
gaa acc acg atg ccc aag gat aac ctt cat cat 1680Val Phe Asn Gly Pro
Glu Thr Thr Met Pro Lys Asp Asn Leu His His 545 550 555 560 ggc aac
tgg gag cac cgt gac atc cat aac gtt cat gga atc acc ctg 1728Gly Asn
Trp Glu His Arg Asp Ile His Asn Val His Gly Ile Thr Leu 565 570 575
gtc aat gcc acc tac gat gcc ctt cta gag cgc aag aag ggc gag atc
1776Val Asn Ala Thr Tyr Asp Ala Leu Leu Glu Arg Lys Lys Gly Glu Ile
580 585 590 cgt cgg cct ttc att ctg aca cgg tca tat tat gct ggt gct
caa cgg 1824Arg Arg Pro Phe Ile Leu Thr Arg Ser Tyr Tyr Ala Gly Ala
Gln Arg 595 600 605 atg tct gct atg tgg acg ggt gat aac cag gct act
tgg gaa cac ttg 1872Met Ser Ala Met Trp Thr Gly Asp Asn Gln Ala Thr
Trp Glu His Leu 610 615 620 gcc gct tcc atc cct atg gtt ctg aac aac
ggc att gcg ggc ttc ccc 1920Ala Ala Ser Ile Pro Met Val Leu Asn Asn
Gly Ile Ala Gly Phe Pro 625 630 635 640 ttt gcc ggt gct gac gtg ggc
ggt ttc ttc cag aac cct agc aag gag 1968Phe Ala Gly Ala Asp Val Gly
Gly Phe Phe Gln Asn Pro Ser Lys Glu 645 650 655 ctc ttg acc aga tgg
tac caa gct ggt att tgg tac ccc ttc ttc cgg 2016Leu Leu Thr Arg Trp
Tyr Gln Ala Gly Ile Trp Tyr Pro Phe Phe Arg 660 665 670 gcc cac gcg
cat att gac acg cgc cgg aga gag ccg tat ctg att gcc 2064Ala His Ala
His Ile Asp Thr Arg Arg Arg Glu Pro Tyr Leu Ile Ala 675 680 685 gag
cca cac cgg tct atc atc tcc cag gct atc cgc ctg agg tat cag 2112Glu
Pro His Arg Ser Ile Ile Ser Gln Ala Ile Arg Leu Arg Tyr Gln 690 695
700 ctt ctc ccc gcc tgg tac act gcc ttc cac gaa gct tcc gtg aac gga
2160Leu Leu Pro Ala Trp Tyr Thr Ala Phe His Glu Ala Ser Val Asn Gly
705 710 715 720 atg ccg atc gtg agg ccg cag tac tac gct cac cct tgg
gat gag gct 2208Met Pro Ile Val Arg Pro Gln Tyr Tyr Ala His Pro Trp
Asp Glu Ala 725 730 735 ggc ttt gcc att gac gac cag ctt tat ctc ggc
tcc acc ggt ctt ctt 2256Gly Phe Ala Ile Asp Asp Gln Leu Tyr Leu Gly
Ser Thr Gly Leu Leu 740 745 750 gct aag cct gtt gtc tcc gag gag gcc
acc acg gcc gac att tac ctt 2304Ala Lys Pro Val Val Ser Glu Glu Ala
Thr Thr Ala Asp Ile Tyr Leu 755 760 765 gct gac gac gaa aag tac tat
gac tac ttt gac tac acc gtc tac cag 2352Ala Asp Asp Glu Lys Tyr Tyr
Asp Tyr Phe Asp Tyr Thr Val Tyr Gln 770 775 780 gga gcc gga aag cgg
cat acg gtg cct gct cct atg gag act gtg cca 2400Gly Ala Gly Lys Arg
His Thr Val Pro Ala Pro Met Glu Thr Val Pro 785 790 795 800 ttg ctg
atg cag ggt ggc cat gta atc ccc cgc aag gac cgt cct cgc 2448Leu Leu
Met Gln Gly Gly His Val Ile Pro Arg Lys Asp Arg Pro Arg 805 810 815
cgc agt agc gcc ttg atg aga tgg gat ccg tac act ctt gtt gtg gtc
2496Arg Ser Ser Ala Leu Met Arg Trp Asp Pro Tyr Thr Leu Val Val Val
820 825 830 ttg gat aag aac ggt caa gcc gat ggc tct ctc tac gtg gat
gac ggt 2544Leu Asp Lys Asn Gly Gln Ala Asp Gly Ser Leu Tyr Val Asp
Asp Gly 835 840 845 gag acg ttc gac tat gag cgt gga gct tat atc cac
cgc cgt ttc cgc 2592Glu Thr Phe Asp Tyr Glu Arg Gly Ala Tyr Ile His
Arg Arg Phe Arg 850 855 860 ttc cag gag tct gcc ctg gtc tcg gag gat
gtt ggc acc aag ggt cct 2640Phe Gln Glu Ser Ala Leu Val Ser Glu Asp
Val Gly Thr Lys Gly Pro 865 870 875 880 aag acg gcc gag tac ttg aag
acc atg gcc aac gtt cgt gtt gag cgg 2688Lys Thr Ala Glu Tyr Leu Lys
Thr Met Ala Asn Val Arg Val Glu Arg 885 890 895 gtg gtg gta gtt gat
cct cct aag gaa tgg cag ggt aag acc agt gtg 2736Val Val Val Val Asp
Pro Pro Lys Glu Trp Gln Gly Lys Thr Ser Val 900 905 910 act gtc att
gag gat gga gct tcg gcg gct tcg aca gcc tct atg cag 2784Thr Val Ile
Glu Asp Gly Ala Ser Ala Ala Ser Thr Ala Ser Met Gln 915 920 925 tac
cac agc cag ccc gat ggc aag
gcc gca tat gcg gtg gtg aag aac 2832Tyr His Ser Gln Pro Asp Gly Lys
Ala Ala Tyr Ala Val Val Lys Asn 930 935 940 ccc aat gtc ggc att gga
aag aca tgg cgg att gag ttt tag 2874Pro Asn Val Gly Ile Gly Lys Thr
Trp Arg Ile Glu Phe 945 950 955 30957PRTAspergillus niger 30Met Ser
Asn Arg Trp Thr Leu Leu Leu Ser Leu Val Ile Leu Leu Gly 1 5 10 15
Cys Leu Val Ile Pro Gly Val Thr Val Lys His Glu Asn Phe Lys Thr 20
25 30 Cys Ser Gln Ser Gly Phe Cys Lys Arg Asn Arg Ala Phe Ala Asp
Asp 35 40 45 Ala Ala Ala Gln Gly Ser Ser Trp Ala Ser Pro Tyr Glu
Leu Asp Ser 50 55 60 Ser Ser Ile Gln Phe Lys Asp Gly Gln Leu His
Gly Thr Ile Leu Lys 65 70 75 80 Ser Val Ser Pro Asn Glu Lys Val Lys
Leu Pro Leu Val Val Ser Phe 85 90 95 Leu Glu Ser Gly Ala Ala Arg
Val Val Val Asp Glu Glu Lys Arg Met 100 105 110 Asn Gly Asp Ile Gln
Leu Arg His Asp Ser Lys Ala Arg Lys Glu Arg 115 120 125 Tyr Asn Glu
Ala Glu Lys Trp Val Leu Val Gly Gly Leu Glu Leu Ser 130 135 140 Lys
Thr Ala Thr Leu Arg Pro Glu Thr Glu Ser Gly Phe Thr Arg Val 145 150
155 160 Leu Tyr Gly Pro Asp Asn Gln Phe Glu Ala Val Ile Arg His Ala
Pro 165 170 175 Phe Ser Ala Asp Phe Lys Arg Asp Gly Gln Thr His Val
Gln Leu Asn 180 185 190 Asn Lys Gly Tyr Leu Asn Met Glu His Trp Arg
Pro Lys Val Glu Val 195 200 205 Glu Gly Glu Gly Glu Gln Gln Thr Gln
Glu Asp Glu Ser Thr Trp Trp 210 215 220 Asp Glu Ser Phe Gly Gly Asn
Thr Asp Thr Lys Pro Arg Gly Pro Glu 225 230 235 240 Ser Val Gly Leu
Asp Ile Thr Phe Pro Gly Tyr Lys His Val Phe Gly 245 250 255 Ile Pro
Glu His Ala Asp Ser Leu Ser Leu Lys Glu Thr Arg Gly Gly 260 265 270
Glu Gly Asn His Glu Glu Pro Tyr Arg Met Tyr Asn Ala Asp Val Phe 275
280 285 Glu Tyr Glu Leu Ser Ser Pro Met Thr Leu Tyr Gly Ala Ile Pro
Phe 290 295 300 Met Gln Ala His Arg Lys Asp Ser Thr Val Gly Val Phe
Trp Leu Asn 305 310 315 320 Ala Ala Glu Thr Trp Val Asp Ile Val Lys
Ser Thr Ser Ser Pro Asn 325 330 335 Pro Leu Ala Leu Gly Val Gly Ala
Thr Thr Asp Thr Gln Ser His Trp 340 345 350 Phe Ser Glu Ser Gly Gln
Leu Asp Val Phe Val Phe Leu Gly Pro Thr 355 360 365 Pro Gln Glu Ile
Ser Lys Thr Tyr Gly Glu Leu Thr Gly Tyr Thr Gln 370 375 380 Leu Pro
Gln His Phe Ala Ile Ala Tyr His Gln Cys Arg Trp Asn Tyr 385 390 395
400 Ile Thr Asp Glu Asp Val Lys Glu Val Asp Arg Asn Phe Asp Lys Tyr
405 410 415 Gln Ile Pro Tyr Asp Val Ile Trp Leu Asp Ile Glu Tyr Thr
Asp Asp 420 425 430 Arg Lys Tyr Phe Thr Trp Asp Pro Leu Ser Phe Pro
Asp Pro Ile Ser 435 440 445 Met Glu Glu Gln Leu Asp Glu Ser Glu Arg
Lys Leu Val Val Ile Ile 450 455 460 Asp Pro His Ile Lys Asn Gln Asp
Lys Tyr Ser Ile Val Gln Glu Met 465 470 475 480 Lys Ser Lys Asp Leu
Ala Thr Lys Asn Lys Asp Gly Glu Ile Tyr Asp 485 490 495 Gly Trp Cys
Trp Pro Gly Ser Ser His Trp Ile Asp Thr Phe Asn Pro 500 505 510 Ala
Ala Ile Lys Trp Trp Val Ser Leu Phe Lys Phe Asp Lys Phe Lys 515 520
525 Gly Thr Leu Ser Asn Val Phe Ile Trp Asn Asp Met Asn Glu Pro Ser
530 535 540 Val Phe Asn Gly Pro Glu Thr Thr Met Pro Lys Asp Asn Leu
His His 545 550 555 560 Gly Asn Trp Glu His Arg Asp Ile His Asn Val
His Gly Ile Thr Leu 565 570 575 Val Asn Ala Thr Tyr Asp Ala Leu Leu
Glu Arg Lys Lys Gly Glu Ile 580 585 590 Arg Arg Pro Phe Ile Leu Thr
Arg Ser Tyr Tyr Ala Gly Ala Gln Arg 595 600 605 Met Ser Ala Met Trp
Thr Gly Asp Asn Gln Ala Thr Trp Glu His Leu 610 615 620 Ala Ala Ser
Ile Pro Met Val Leu Asn Asn Gly Ile Ala Gly Phe Pro 625 630 635 640
Phe Ala Gly Ala Asp Val Gly Gly Phe Phe Gln Asn Pro Ser Lys Glu 645
650 655 Leu Leu Thr Arg Trp Tyr Gln Ala Gly Ile Trp Tyr Pro Phe Phe
Arg 660 665 670 Ala His Ala His Ile Asp Thr Arg Arg Arg Glu Pro Tyr
Leu Ile Ala 675 680 685 Glu Pro His Arg Ser Ile Ile Ser Gln Ala Ile
Arg Leu Arg Tyr Gln 690 695 700 Leu Leu Pro Ala Trp Tyr Thr Ala Phe
His Glu Ala Ser Val Asn Gly 705 710 715 720 Met Pro Ile Val Arg Pro
Gln Tyr Tyr Ala His Pro Trp Asp Glu Ala 725 730 735 Gly Phe Ala Ile
Asp Asp Gln Leu Tyr Leu Gly Ser Thr Gly Leu Leu 740 745 750 Ala Lys
Pro Val Val Ser Glu Glu Ala Thr Thr Ala Asp Ile Tyr Leu 755 760 765
Ala Asp Asp Glu Lys Tyr Tyr Asp Tyr Phe Asp Tyr Thr Val Tyr Gln 770
775 780 Gly Ala Gly Lys Arg His Thr Val Pro Ala Pro Met Glu Thr Val
Pro 785 790 795 800 Leu Leu Met Gln Gly Gly His Val Ile Pro Arg Lys
Asp Arg Pro Arg 805 810 815 Arg Ser Ser Ala Leu Met Arg Trp Asp Pro
Tyr Thr Leu Val Val Val 820 825 830 Leu Asp Lys Asn Gly Gln Ala Asp
Gly Ser Leu Tyr Val Asp Asp Gly 835 840 845 Glu Thr Phe Asp Tyr Glu
Arg Gly Ala Tyr Ile His Arg Arg Phe Arg 850 855 860 Phe Gln Glu Ser
Ala Leu Val Ser Glu Asp Val Gly Thr Lys Gly Pro 865 870 875 880 Lys
Thr Ala Glu Tyr Leu Lys Thr Met Ala Asn Val Arg Val Glu Arg 885 890
895 Val Val Val Val Asp Pro Pro Lys Glu Trp Gln Gly Lys Thr Ser Val
900 905 910 Thr Val Ile Glu Asp Gly Ala Ser Ala Ala Ser Thr Ala Ser
Met Gln 915 920 925 Tyr His Ser Gln Pro Asp Gly Lys Ala Ala Tyr Ala
Val Val Lys Asn 930 935 940 Pro Asn Val Gly Ile Gly Lys Thr Trp Arg
Ile Glu Phe 945 950 955 312303DNAAspergillus niger 31agcggcaggc
cgataaggag ctgagtcagc gagccccaga atgggcgggc gattatcacc 60agctggccag
aagctctctc cgcattcctg atggtggatt gattgatgaa ttgattgctt
120ttttgtcttg ctcttgttag tttgttctct agtgccccta cacagcattg
gtcagggagc 180tcaatgctgc cactgccacc atgatacttc ctcagggatc
gctcttcttg gtgagcatag 240ctgcttgctc gaccgtcgtg gctgcggcgg
gtgatgcctc ctctcgtccc cggggtgtag 300gtcccgaatg taagtgccac
ttatatacct acttaggctg aggcggtgct acacgcaacc 360attctattcc
aacttgcatc ctcgccataa tcttgttttt ttgtcggcat tggtcatgct
420aactggtttc gtctaatggt tggcagtcgc caagttctac aaggatacca
ccaccttcac 480gtgcatctcc cacccagcca tccagatccc cttctccgcc
gtgaacgatg attactgtga 540ctgtccggat ggcagtgatg agcctggcac
atctgcctgt gccttcctgt ctcgcaactc 600cgccctaaca ccgggtgagc
gccccggcag cgacgatctc gagctgacat ccgccctgcc 660gggtttctac
tgcaagaaca agggccacaa gcccggctac gtccccttcc agcgggtcaa
720tgacggcatc tgtgactatg agctctgctg cgacggcagt gacgagtggg
cccgccctgg 780cggcaccaag tgtgaagaca agtgcaagga gatcggcaag
gaatggcgga agaaggagga 840gaagagacag aagtccatga ctgcggcttt
gaagaagaag aaggatctgc ttgtggaggc 900tggtagacag cagaaggagg
tcgaggacaa tatcaagcgt ctggaagttg aaattcaggc 960ccaggagctg
aaggtcaatg atcttcaggc ggagctggag gaggtggagc agcaggaggc
1020gagcaaggtc gtgaagggca agacggcggg caaggttaat gtgcttgctg
ggttggctaa 1080gagccgggtt gaggagcttc gaaacgccct gatggacgtc
cgcaaggagc gtgatgatac 1140ccgtgcccgt gtgaaggagc tcgaagagat
tctgtctaag ttcaaggtgg aatacaaccc 1200taacttcaac gatgagggcg
ttaagcgcgc tgtgcgcagc tgggaagact acgccgccaa 1260gggcaccctt
gagggcgccg tgaacaacgc tcaggaccgt gatttggatg aaattgctaa
1320gcccgatgat gagaaggcgg gcatcaactg ggaacagtgg gagaatgaag
aggatgggtg 1380tgaggctggt cttggtatgt aaatcatttc agagtgaggg
ttatcgatgt tcccgcgcta 1440acatcagatt tagtctacca gctggcagcc
taccttccgc cttctttggt cgagtttatc 1500gaaggcaagg tgctcttcgt
cagaggtctc ttggaagata acggaattct acccaaggcg 1560gccgagactt
ctacgtccga atccaaggtt gtgtcagaag cccgagaagc cgtgaagtca
1620gcagagaagg agcttggaga caagcagaag cagctgaagg atcacaagtc
cgatcttgag 1680acggactatg gtgtcggatc catcttccgt gccctcaagg
gcgtttgcat ctccaaggac 1740tcgggtgagt acacgtatga gcactgcttc
ctggaccaga caaaacagat tccaaagaag 1800ggcggcggat ccacacgcat
gggcaagtac accggcattg ggtcggtcag tgttgatgtg 1860ctcaacgagg
cgggcgagat tgtccccgaa gacagggtca ctcttcagta cgccaacgga
1920caaggctgct ggaatggacc ggcccgctcg acgacggtca tcctgacatg
cggcgaagag 1980gatgcgatcc tgaaggtggc cgaagacgag aagtgcgtgt
actcgatgca tgtcacgtcg 2040ccggccgtgt gtcccggagg cgatgagggc
gcaactgccc cgaaccgcaa ggatgagctg 2100tgagcagtga tgggaccata
tttagggtta tatcagagcg ctacaagtct ataggttttg 2160cttatttgaa
ttgcatacac agcatctgtt gttctgacag caatcatgag ctactgacct
2220aatggcctta gtattgacta ggcagctgcc aactagcaga actgctgatt
agcgggtggc 2280atcggagtag cttctgttgc tta 2303321707DNAAspergillus
nigerCDS(1)..(1707) 32atg ata ctt cct cag gga tcg ctc ttc ttg gtg
agc ata gct gct tgc 48Met Ile Leu Pro Gln Gly Ser Leu Phe Leu Val
Ser Ile Ala Ala Cys 1 5 10 15 tcg acc gtc gtg gct gcg gcg ggt gat
gcc tcc tct cgt ccc cgg ggt 96Ser Thr Val Val Ala Ala Ala Gly Asp
Ala Ser Ser Arg Pro Arg Gly 20 25 30 gta ggt ccc gaa ttc gcc aag
ttc tac aag gat acc acc acc ttc acg 144Val Gly Pro Glu Phe Ala Lys
Phe Tyr Lys Asp Thr Thr Thr Phe Thr 35 40 45 tgc atc tcc cac cca
gcc atc cag atc ccc ttc tcc gcc gtg aac gat 192Cys Ile Ser His Pro
Ala Ile Gln Ile Pro Phe Ser Ala Val Asn Asp 50 55 60 gat tac tgt
gac tgt ccg gat ggc agt gat gag cct ggc aca tct gcc 240Asp Tyr Cys
Asp Cys Pro Asp Gly Ser Asp Glu Pro Gly Thr Ser Ala 65 70 75 80 tgt
gcc ttc ctg tct cgc aac tcc gcc cta aca ccg ggt gag cgc ccc 288Cys
Ala Phe Leu Ser Arg Asn Ser Ala Leu Thr Pro Gly Glu Arg Pro 85 90
95 ggc agc gac gat ctc gag ctg aca tcc gcc ctg ccg ggt ttc tac tgc
336Gly Ser Asp Asp Leu Glu Leu Thr Ser Ala Leu Pro Gly Phe Tyr Cys
100 105 110 aag aac aag ggc cac aag ccc ggc tac gtc ccc ttc cag cgg
gtc aat 384Lys Asn Lys Gly His Lys Pro Gly Tyr Val Pro Phe Gln Arg
Val Asn 115 120 125 gac ggc atc tgt gac tat gag ctc tgc tgc gac ggc
agt gac gag tgg 432Asp Gly Ile Cys Asp Tyr Glu Leu Cys Cys Asp Gly
Ser Asp Glu Trp 130 135 140 gcc cgc cct ggc ggc acc aag tgt gaa gac
aag tgc aag gag atc ggc 480Ala Arg Pro Gly Gly Thr Lys Cys Glu Asp
Lys Cys Lys Glu Ile Gly 145 150 155 160 aag gaa tgg cgg aag aag gag
gag aag aga cag aag tcc atg act gcg 528Lys Glu Trp Arg Lys Lys Glu
Glu Lys Arg Gln Lys Ser Met Thr Ala 165 170 175 gct ttg aag aag aag
aag gat ctg ctt gtg gag gct ggt aga cag cag 576Ala Leu Lys Lys Lys
Lys Asp Leu Leu Val Glu Ala Gly Arg Gln Gln 180 185 190 aag gag gtc
gag gac aat atc aag cgt ctg gaa gtt gaa att cag gcc 624Lys Glu Val
Glu Asp Asn Ile Lys Arg Leu Glu Val Glu Ile Gln Ala 195 200 205 cag
gag ctg aag gtc aat gat ctt cag gcg gag ctg gag gag gtg gag 672Gln
Glu Leu Lys Val Asn Asp Leu Gln Ala Glu Leu Glu Glu Val Glu 210 215
220 cag cag gag gcg agc aag gtc gtg aag ggc aag acg gcg ggc aag gtt
720Gln Gln Glu Ala Ser Lys Val Val Lys Gly Lys Thr Ala Gly Lys Val
225 230 235 240 aat gtg ctt gct ggg ttg gct aag agc cgg gtt gag gag
ctt cga aac 768Asn Val Leu Ala Gly Leu Ala Lys Ser Arg Val Glu Glu
Leu Arg Asn 245 250 255 gcc ctg atg gac gtc cgc aag gag cgt gat gat
acc cgt gcc cgt gtg 816Ala Leu Met Asp Val Arg Lys Glu Arg Asp Asp
Thr Arg Ala Arg Val 260 265 270 aag gag ctc gaa gag att ctg tct aag
ttc aag gtg gaa tac aac cct 864Lys Glu Leu Glu Glu Ile Leu Ser Lys
Phe Lys Val Glu Tyr Asn Pro 275 280 285 aac ttc aac gat gag ggc gtt
aag cgc gct gtg cgc agc tgg gaa gac 912Asn Phe Asn Asp Glu Gly Val
Lys Arg Ala Val Arg Ser Trp Glu Asp 290 295 300 tac gcc gcc aag ggc
acc ctt gag ggc gcc gtg aac aac gct cag gac 960Tyr Ala Ala Lys Gly
Thr Leu Glu Gly Ala Val Asn Asn Ala Gln Asp 305 310 315 320 cgt gat
ttg gat gaa att gct aag ccc gat gat gag aag gcg ggc atc 1008Arg Asp
Leu Asp Glu Ile Ala Lys Pro Asp Asp Glu Lys Ala Gly Ile 325 330 335
aac tgg gaa cag tgg gag aat gaa gag gat ggg tgt gag gct ggt ctt
1056Asn Trp Glu Gln Trp Glu Asn Glu Glu Asp Gly Cys Glu Ala Gly Leu
340 345 350 gtc tac cag ctg gca gcc tac ctt ccg cct tct ttg gtc gag
ttt atc 1104Val Tyr Gln Leu Ala Ala Tyr Leu Pro Pro Ser Leu Val Glu
Phe Ile 355 360 365 gaa ggc aag gtg ctc ttc gtc aga ggt ctc ttg gaa
gat aac gga att 1152Glu Gly Lys Val Leu Phe Val Arg Gly Leu Leu Glu
Asp Asn Gly Ile 370 375 380 cta ccc aag gcg gcc gag act tct acg tcc
gaa tcc aag gtt gtg tca 1200Leu Pro Lys Ala Ala Glu Thr Ser Thr Ser
Glu Ser Lys Val Val Ser 385 390 395 400 gaa gcc cga gaa gcc gtg aag
tca gca gag aag gag ctt gga gac aag 1248Glu Ala Arg Glu Ala Val Lys
Ser Ala Glu Lys Glu Leu Gly Asp Lys 405 410 415 cag aag cag ctg aag
gat cac aag tcc gat ctt gag acg gac tat ggt 1296Gln Lys Gln Leu Lys
Asp His Lys Ser Asp Leu Glu Thr Asp Tyr Gly 420 425 430 gtc gga tcc
atc ttc cgt gcc ctc aag ggc gtt tgc atc tcc aag gac 1344Val Gly Ser
Ile Phe Arg Ala Leu Lys Gly Val Cys Ile Ser Lys Asp 435 440 445 tcg
ggt gag tac acg tat gag cac tgc ttc ctg gac cag aca aaa cag 1392Ser
Gly Glu Tyr Thr Tyr Glu His Cys Phe Leu Asp Gln Thr Lys Gln 450 455
460 att cca aag aag ggc ggc gga tcc aca cgc atg ggc aag tac acc ggc
1440Ile Pro Lys Lys Gly Gly Gly Ser Thr Arg Met Gly Lys Tyr Thr Gly
465 470 475 480 att ggg tcg gtc agt gtt gat gtg ctc aac gag gcg ggc
gag att gtc 1488Ile Gly Ser Val Ser Val Asp Val Leu Asn Glu Ala Gly
Glu Ile Val 485 490 495 ccc gaa gac agg gtc act ctt cag tac gcc aac
gga caa ggc tgc tgg 1536Pro Glu Asp Arg Val Thr Leu Gln Tyr Ala Asn
Gly Gln Gly Cys Trp 500 505 510 aat gga ccg gcc cgc tcg acg acg gtc
atc ctg aca tgc ggc gaa gag 1584Asn Gly Pro Ala Arg Ser Thr Thr Val
Ile Leu Thr Cys Gly Glu Glu 515 520 525 gat gcg atc ctg aag gtg gcc
gaa gac gag aag tgc gtg tac tcg atg 1632Asp Ala Ile Leu Lys Val Ala
Glu Asp Glu Lys Cys Val Tyr Ser Met 530 535 540 cat gtc acg tcg ccg
gcc gtg tgt ccc gga ggc gat gag ggc gca act 1680His Val Thr Ser Pro
Ala Val Cys Pro Gly Gly Asp Glu Gly Ala Thr 545 550 555 560 gcc ccg
aac cgc aag gat gag ctg tga 1707Ala Pro Asn Arg Lys Asp Glu Leu 565
33568PRTAspergillus niger 33Met Ile Leu Pro Gln Gly Ser Leu Phe Leu
Val Ser Ile Ala Ala Cys 1 5 10 15 Ser Thr Val Val Ala Ala Ala Gly
Asp Ala Ser Ser Arg Pro Arg Gly 20 25
30 Val Gly Pro Glu Phe Ala Lys Phe Tyr Lys Asp Thr Thr Thr Phe Thr
35 40 45 Cys Ile Ser His Pro Ala Ile Gln Ile Pro Phe Ser Ala Val
Asn Asp 50 55 60 Asp Tyr Cys Asp Cys Pro Asp Gly Ser Asp Glu Pro
Gly Thr Ser Ala 65 70 75 80 Cys Ala Phe Leu Ser Arg Asn Ser Ala Leu
Thr Pro Gly Glu Arg Pro 85 90 95 Gly Ser Asp Asp Leu Glu Leu Thr
Ser Ala Leu Pro Gly Phe Tyr Cys 100 105 110 Lys Asn Lys Gly His Lys
Pro Gly Tyr Val Pro Phe Gln Arg Val Asn 115 120 125 Asp Gly Ile Cys
Asp Tyr Glu Leu Cys Cys Asp Gly Ser Asp Glu Trp 130 135 140 Ala Arg
Pro Gly Gly Thr Lys Cys Glu Asp Lys Cys Lys Glu Ile Gly 145 150 155
160 Lys Glu Trp Arg Lys Lys Glu Glu Lys Arg Gln Lys Ser Met Thr Ala
165 170 175 Ala Leu Lys Lys Lys Lys Asp Leu Leu Val Glu Ala Gly Arg
Gln Gln 180 185 190 Lys Glu Val Glu Asp Asn Ile Lys Arg Leu Glu Val
Glu Ile Gln Ala 195 200 205 Gln Glu Leu Lys Val Asn Asp Leu Gln Ala
Glu Leu Glu Glu Val Glu 210 215 220 Gln Gln Glu Ala Ser Lys Val Val
Lys Gly Lys Thr Ala Gly Lys Val 225 230 235 240 Asn Val Leu Ala Gly
Leu Ala Lys Ser Arg Val Glu Glu Leu Arg Asn 245 250 255 Ala Leu Met
Asp Val Arg Lys Glu Arg Asp Asp Thr Arg Ala Arg Val 260 265 270 Lys
Glu Leu Glu Glu Ile Leu Ser Lys Phe Lys Val Glu Tyr Asn Pro 275 280
285 Asn Phe Asn Asp Glu Gly Val Lys Arg Ala Val Arg Ser Trp Glu Asp
290 295 300 Tyr Ala Ala Lys Gly Thr Leu Glu Gly Ala Val Asn Asn Ala
Gln Asp 305 310 315 320 Arg Asp Leu Asp Glu Ile Ala Lys Pro Asp Asp
Glu Lys Ala Gly Ile 325 330 335 Asn Trp Glu Gln Trp Glu Asn Glu Glu
Asp Gly Cys Glu Ala Gly Leu 340 345 350 Val Tyr Gln Leu Ala Ala Tyr
Leu Pro Pro Ser Leu Val Glu Phe Ile 355 360 365 Glu Gly Lys Val Leu
Phe Val Arg Gly Leu Leu Glu Asp Asn Gly Ile 370 375 380 Leu Pro Lys
Ala Ala Glu Thr Ser Thr Ser Glu Ser Lys Val Val Ser 385 390 395 400
Glu Ala Arg Glu Ala Val Lys Ser Ala Glu Lys Glu Leu Gly Asp Lys 405
410 415 Gln Lys Gln Leu Lys Asp His Lys Ser Asp Leu Glu Thr Asp Tyr
Gly 420 425 430 Val Gly Ser Ile Phe Arg Ala Leu Lys Gly Val Cys Ile
Ser Lys Asp 435 440 445 Ser Gly Glu Tyr Thr Tyr Glu His Cys Phe Leu
Asp Gln Thr Lys Gln 450 455 460 Ile Pro Lys Lys Gly Gly Gly Ser Thr
Arg Met Gly Lys Tyr Thr Gly 465 470 475 480 Ile Gly Ser Val Ser Val
Asp Val Leu Asn Glu Ala Gly Glu Ile Val 485 490 495 Pro Glu Asp Arg
Val Thr Leu Gln Tyr Ala Asn Gly Gln Gly Cys Trp 500 505 510 Asn Gly
Pro Ala Arg Ser Thr Thr Val Ile Leu Thr Cys Gly Glu Glu 515 520 525
Asp Ala Ile Leu Lys Val Ala Glu Asp Glu Lys Cys Val Tyr Ser Met 530
535 540 His Val Thr Ser Pro Ala Val Cys Pro Gly Gly Asp Glu Gly Ala
Thr 545 550 555 560 Ala Pro Asn Arg Lys Asp Glu Leu 565
342343DNAAspergillus niger 34gcctgaccac gatcgaccgt tgacaatcca
ggcttccctt ccgtcgctga tcttcatgtg 60aaggaccctg ttttcttgct tacctaccat
agaccttcat tgcatagctt cactctatac 120tctcttggtt tctgtcatac
actccaattc cttcctccgt ccttgtccac tcgtttccgc 180cggtctccgg
ctattccaag atgcgctccg cagccaaatt tttctatttg gcggtatttg
240ccctgtcgag gctttccaat gccgagactg ggctgcacca taaccaggac
aagtgtgcgg 300taagtcgata caacgctcgg gcatacgctt ggactgcatg
ttgtagaccg gacttggctg 360attcattctc atctctacca gattgacccc
actgccatgg tgtccgacgc ttgtgtctcc 420tacgccacta tcgatcatct
gaacgatcaa gtctacaccc tcctccaatc cattacgcaa 480gataccgatt
tcttctcgta ctaccgtctt aatctcttca acaaagtctg tccattctgg
540tccgatgcga atagtatgtg cgggaacatt gcatgctccg tcaacacaat
cgaatctgaa 600gacgacattc cgttaacatg gcgcgcggag gagctcagta
aactcgaggg acccaaagca 660ggccatccgg gccgcaatca acgaaaggag
cgacctctta atcgaccgct ccaaggaatg 720ctaggcgaaa atgttggaga
gagctgtgtg gtggagtatg acgatgaatg tgatgaacgg 780gactactgtg
ttcccgaaga tgagggtgct agcggcaagg gagactatgt cagtctcgtt
840gataatccag aacggttcac agggtatgcc ggtatgggcg cccatcaggt
ttgggatgca 900atctatcggg agaattgctt cctcaaaccg gtgcccgagc
tatcacccgt tactcctcag 960ctgggtggtc ttcaagctgt caacgatttc
cgtcatgtgc ttcagcagga gttgaagcgc 1020cctgacctgc ttccattgga
caatgaatgc cttgagaagc gagtgttcca tcgtctcatc 1080agcggaatgc
atgcgtctat ctcgacccac ctttgctggg actacctaaa ccagacgacg
1140ggacaatggc atcctaacct tcaatgcttc aaagatcgtc tccacgatca
ccccgagcgc 1200atctcgaacc tgtacttcaa ctacgcgctg gtctcgcgcg
ccgtggcgaa gctgcagaaa 1260cacctacaca actacaacta ctgcgtcggt
gatccggtcc aggatgccat gactagggag 1320aaggtctcca agttgacctc
gaccttggct gaccgccctc aaattttcga cgagaacgtc 1380atgttccagg
atcccagctc cgctggcctg aaggaagact tccgcaaccg attccgcaac
1440gtcagtcgcc tgatggactg cgtcgggtgc gacaaatgcc gcctctgggg
caagctccag 1500gtcaacggat atggcaccgc tctgaaagtg ctgttcgagt
acgacgagac taagaacggc 1560gagaacccgt tgctgcgccg gactgagctg
gtggcactga tcaataccct tggtcgcatt 1620tctcacagca ttgccgccgt
ccggagtttc caccgggcca tggatgtggg cgatggggag 1680gtcttcacca
tccccgcgag cattgcgtcc aaggagcgcg gtggcaagaa gaagacccga
1740cgacttctca aagacggtgg ctcaaccttc tattatgagg atggcgatga
tgacaacttt 1800gtctacatca ccgagaaact tccgtgggag aaggtccggg
tacgccgcga cacggatacg 1860gtctgggatg atattaaggc cgagttttct
atgatctggg acatttacgt ctatgtgctg 1920aagagctggg tcaatgcacc
aaagacattg taagtgatgg catacgatga cctccacagt 1980ttcctatata
ctaactgggc attgcagctt cgagatcgcc gtcctggagg ttgctcgggt
2040atggaactac tggctgggtc tgcctgtgcc gccacggtcc tggaggatcc
agcttcccaa 2100gcgacccacc cctccaacac ccccgaccca tgaggagctc
tagacggtag aagtgggcaa 2160ggcgacgtgg tggaagatgg cggtgactgg
gattgtattg tataactagc gtcgttgagg 2220actaatcttt ttccgatctg
tttgggccgg cgttgttgac gatgcctgtt gggaaatcgc 2280atctcgggag
ttctgggagc attttaggcc gctgtacata tttcaagcaa tgggcctgag 2340cat
2343351803DNAAspergillus nigerCDS(1)..(1803) 35atg cgc tcc gca gcc
aaa ttt ttc tat ttg gcg gta ttt gcc ctg tcg 48Met Arg Ser Ala Ala
Lys Phe Phe Tyr Leu Ala Val Phe Ala Leu Ser 1 5 10 15 agg ctt tcc
aat gcc gag act ggg ctg cac cat aac cag gac aag tgt 96Arg Leu Ser
Asn Ala Glu Thr Gly Leu His His Asn Gln Asp Lys Cys 20 25 30 gcg
att gac ccc act gcc atg gtg tcc gac gct tgt gtc tcc tac gcc 144Ala
Ile Asp Pro Thr Ala Met Val Ser Asp Ala Cys Val Ser Tyr Ala 35 40
45 act atc gat cat ctg aac gat caa gtc tac acc ctc ctc caa tcc att
192Thr Ile Asp His Leu Asn Asp Gln Val Tyr Thr Leu Leu Gln Ser Ile
50 55 60 acg caa gat acc gat ttc ttc tcg tac tac cgt ctt aat ctc
ttc aac 240Thr Gln Asp Thr Asp Phe Phe Ser Tyr Tyr Arg Leu Asn Leu
Phe Asn 65 70 75 80 aaa gtc tgt cca ttc tgg tcc gat gcg aat agt atg
tgc ggg aac att 288Lys Val Cys Pro Phe Trp Ser Asp Ala Asn Ser Met
Cys Gly Asn Ile 85 90 95 gca tgc tcc gtc aac aca atc gaa tct gaa
gac gac att ccg tta aca 336Ala Cys Ser Val Asn Thr Ile Glu Ser Glu
Asp Asp Ile Pro Leu Thr 100 105 110 tgg cgc gcg gag gag ctc agt aaa
ctc gag gga ccc aaa gca ggc cat 384Trp Arg Ala Glu Glu Leu Ser Lys
Leu Glu Gly Pro Lys Ala Gly His 115 120 125 ccg ggc cgc aat caa cga
aag gag cga cct ctt aat cga ccg ctc caa 432Pro Gly Arg Asn Gln Arg
Lys Glu Arg Pro Leu Asn Arg Pro Leu Gln 130 135 140 gga atg cta ggc
gaa aat gtt gga gag agc tgt gtg gtg gag tat gac 480Gly Met Leu Gly
Glu Asn Val Gly Glu Ser Cys Val Val Glu Tyr Asp 145 150 155 160 gat
gaa tgt gat gaa cgg gac tac tgt gtt ccc gaa gat gag ggt gct 528Asp
Glu Cys Asp Glu Arg Asp Tyr Cys Val Pro Glu Asp Glu Gly Ala 165 170
175 agc ggc aag gga gac tat gtc agt ctc gtt gat aat cca gaa cgg ttc
576Ser Gly Lys Gly Asp Tyr Val Ser Leu Val Asp Asn Pro Glu Arg Phe
180 185 190 aca ggg tat gcc ggt atg ggc gcc cat cag gtt tgg gat gca
atc tat 624Thr Gly Tyr Ala Gly Met Gly Ala His Gln Val Trp Asp Ala
Ile Tyr 195 200 205 cgg gag aat tgc ttc ctc aaa ccg gtg ccc gag cta
tca ccc gtt act 672Arg Glu Asn Cys Phe Leu Lys Pro Val Pro Glu Leu
Ser Pro Val Thr 210 215 220 cct cag ctg ggt ggt ctt caa gct gtc aac
gat ttc cgt cat gtg ctt 720Pro Gln Leu Gly Gly Leu Gln Ala Val Asn
Asp Phe Arg His Val Leu 225 230 235 240 cag cag gag ttg aag cgc cct
gac ctg ctt cca ttg gac aat gaa tgc 768Gln Gln Glu Leu Lys Arg Pro
Asp Leu Leu Pro Leu Asp Asn Glu Cys 245 250 255 ctt gag aag cga gtg
ttc cat cgt ctc atc agc gga atg cat gcg tct 816Leu Glu Lys Arg Val
Phe His Arg Leu Ile Ser Gly Met His Ala Ser 260 265 270 atc tcg acc
cac ctt tgc tgg gac tac cta aac cag acg acg gga caa 864Ile Ser Thr
His Leu Cys Trp Asp Tyr Leu Asn Gln Thr Thr Gly Gln 275 280 285 tgg
cat cct aac ctt caa tgc ttc aaa gat cgt ctc cac gat cac ccc 912Trp
His Pro Asn Leu Gln Cys Phe Lys Asp Arg Leu His Asp His Pro 290 295
300 gag cgc atc tcg aac ctg tac ttc aac tac gcg ctg gtc tcg cgc gcc
960Glu Arg Ile Ser Asn Leu Tyr Phe Asn Tyr Ala Leu Val Ser Arg Ala
305 310 315 320 gtg gcg aag ctg cag aaa cac cta cac aac tac aac tac
tgc gtc ggt 1008Val Ala Lys Leu Gln Lys His Leu His Asn Tyr Asn Tyr
Cys Val Gly 325 330 335 gat ccg gtc cag gat gcc atg act agg gag aag
gtc tcc aag ttg acc 1056Asp Pro Val Gln Asp Ala Met Thr Arg Glu Lys
Val Ser Lys Leu Thr 340 345 350 tcg acc ttg gct gac cgc cct caa att
ttc gac gag aac gtc atg ttc 1104Ser Thr Leu Ala Asp Arg Pro Gln Ile
Phe Asp Glu Asn Val Met Phe 355 360 365 cag gat ccc agc tcc gct ggc
ctg aag gaa gac ttc cgc aac cga ttc 1152Gln Asp Pro Ser Ser Ala Gly
Leu Lys Glu Asp Phe Arg Asn Arg Phe 370 375 380 cgc aac gtc agt cgc
ctg atg gac tgc gtc ggg tgc gac aaa tgc cgc 1200Arg Asn Val Ser Arg
Leu Met Asp Cys Val Gly Cys Asp Lys Cys Arg 385 390 395 400 ctc tgg
ggc aag ctc cag gtc aac gga tat ggc acc gct ctg aaa gtg 1248Leu Trp
Gly Lys Leu Gln Val Asn Gly Tyr Gly Thr Ala Leu Lys Val 405 410 415
ctg ttc gag tac gac gag act aag aac ggc gag aac ccg ttg ctg cgc
1296Leu Phe Glu Tyr Asp Glu Thr Lys Asn Gly Glu Asn Pro Leu Leu Arg
420 425 430 cgg act gag ctg gtg gca ctg atc aat acc ctt ggt cgc att
tct cac 1344Arg Thr Glu Leu Val Ala Leu Ile Asn Thr Leu Gly Arg Ile
Ser His 435 440 445 agc att gcc gcc gtc cgg agt ttc cac cgg gcc atg
gat gtg ggc gat 1392Ser Ile Ala Ala Val Arg Ser Phe His Arg Ala Met
Asp Val Gly Asp 450 455 460 ggg gag gtc ttc acc atc ccc gcg agc att
gcg tcc aag gag cgc ggt 1440Gly Glu Val Phe Thr Ile Pro Ala Ser Ile
Ala Ser Lys Glu Arg Gly 465 470 475 480 ggc aag aag aag acc cga cga
ctt ctc aaa gac ggt ggc tca acc ttc 1488Gly Lys Lys Lys Thr Arg Arg
Leu Leu Lys Asp Gly Gly Ser Thr Phe 485 490 495 tat tat gag gat ggc
gat gat gac aac ttt gtc tac atc acc gag aaa 1536Tyr Tyr Glu Asp Gly
Asp Asp Asp Asn Phe Val Tyr Ile Thr Glu Lys 500 505 510 ctt ccg tgg
gag aag gtc cgg gta cgc cgc gac acg gat acg gtc tgg 1584Leu Pro Trp
Glu Lys Val Arg Val Arg Arg Asp Thr Asp Thr Val Trp 515 520 525 gat
gat att aag gcc gag ttt tct atg atc tgg gac att tac gtc tat 1632Asp
Asp Ile Lys Ala Glu Phe Ser Met Ile Trp Asp Ile Tyr Val Tyr 530 535
540 gtg ctg aag agc tgg gtc aat gca cca aag aca ttc ttc gag atc gcc
1680Val Leu Lys Ser Trp Val Asn Ala Pro Lys Thr Phe Phe Glu Ile Ala
545 550 555 560 gtc ctg gag gtt gct cgg gta tgg aac tac tgg ctg ggt
ctg cct gtg 1728Val Leu Glu Val Ala Arg Val Trp Asn Tyr Trp Leu Gly
Leu Pro Val 565 570 575 ccg cca cgg tcc tgg agg atc cag ctt ccc aag
cga ccc acc cct cca 1776Pro Pro Arg Ser Trp Arg Ile Gln Leu Pro Lys
Arg Pro Thr Pro Pro 580 585 590 aca ccc ccg acc cat gag gag ctc tag
1803Thr Pro Pro Thr His Glu Glu Leu 595 600 36600PRTAspergillus
niger 36Met Arg Ser Ala Ala Lys Phe Phe Tyr Leu Ala Val Phe Ala Leu
Ser 1 5 10 15 Arg Leu Ser Asn Ala Glu Thr Gly Leu His His Asn Gln
Asp Lys Cys 20 25 30 Ala Ile Asp Pro Thr Ala Met Val Ser Asp Ala
Cys Val Ser Tyr Ala 35 40 45 Thr Ile Asp His Leu Asn Asp Gln Val
Tyr Thr Leu Leu Gln Ser Ile 50 55 60 Thr Gln Asp Thr Asp Phe Phe
Ser Tyr Tyr Arg Leu Asn Leu Phe Asn 65 70 75 80 Lys Val Cys Pro Phe
Trp Ser Asp Ala Asn Ser Met Cys Gly Asn Ile 85 90 95 Ala Cys Ser
Val Asn Thr Ile Glu Ser Glu Asp Asp Ile Pro Leu Thr 100 105 110 Trp
Arg Ala Glu Glu Leu Ser Lys Leu Glu Gly Pro Lys Ala Gly His 115 120
125 Pro Gly Arg Asn Gln Arg Lys Glu Arg Pro Leu Asn Arg Pro Leu Gln
130 135 140 Gly Met Leu Gly Glu Asn Val Gly Glu Ser Cys Val Val Glu
Tyr Asp 145 150 155 160 Asp Glu Cys Asp Glu Arg Asp Tyr Cys Val Pro
Glu Asp Glu Gly Ala 165 170 175 Ser Gly Lys Gly Asp Tyr Val Ser Leu
Val Asp Asn Pro Glu Arg Phe 180 185 190 Thr Gly Tyr Ala Gly Met Gly
Ala His Gln Val Trp Asp Ala Ile Tyr 195 200 205 Arg Glu Asn Cys Phe
Leu Lys Pro Val Pro Glu Leu Ser Pro Val Thr 210 215 220 Pro Gln Leu
Gly Gly Leu Gln Ala Val Asn Asp Phe Arg His Val Leu 225 230 235 240
Gln Gln Glu Leu Lys Arg Pro Asp Leu Leu Pro Leu Asp Asn Glu Cys 245
250 255 Leu Glu Lys Arg Val Phe His Arg Leu Ile Ser Gly Met His Ala
Ser 260 265 270 Ile Ser Thr His Leu Cys Trp Asp Tyr Leu Asn Gln Thr
Thr Gly Gln 275 280 285 Trp His Pro Asn Leu Gln Cys Phe Lys Asp Arg
Leu His Asp His Pro 290 295 300 Glu Arg Ile Ser Asn Leu Tyr Phe Asn
Tyr Ala Leu Val Ser Arg Ala 305 310 315 320 Val Ala Lys Leu Gln Lys
His Leu His Asn Tyr Asn Tyr Cys Val Gly 325 330 335 Asp Pro Val Gln
Asp Ala Met Thr Arg Glu Lys Val Ser Lys Leu Thr 340 345 350 Ser Thr
Leu Ala Asp Arg Pro Gln Ile Phe Asp Glu Asn Val Met Phe 355 360 365
Gln Asp Pro Ser Ser Ala Gly Leu Lys Glu Asp Phe Arg Asn Arg Phe 370
375 380 Arg Asn Val Ser Arg Leu Met Asp Cys Val Gly Cys Asp Lys Cys
Arg 385 390 395 400 Leu Trp Gly Lys Leu Gln Val Asn Gly Tyr Gly Thr
Ala Leu Lys Val 405 410 415 Leu Phe Glu Tyr Asp Glu Thr Lys Asn Gly
Glu Asn Pro Leu Leu Arg 420 425 430 Arg Thr Glu Leu Val Ala Leu Ile
Asn
Thr Leu Gly Arg Ile Ser His 435 440 445 Ser Ile Ala Ala Val Arg Ser
Phe His Arg Ala Met Asp Val Gly Asp 450 455 460 Gly Glu Val Phe Thr
Ile Pro Ala Ser Ile Ala Ser Lys Glu Arg Gly 465 470 475 480 Gly Lys
Lys Lys Thr Arg Arg Leu Leu Lys Asp Gly Gly Ser Thr Phe 485 490 495
Tyr Tyr Glu Asp Gly Asp Asp Asp Asn Phe Val Tyr Ile Thr Glu Lys 500
505 510 Leu Pro Trp Glu Lys Val Arg Val Arg Arg Asp Thr Asp Thr Val
Trp 515 520 525 Asp Asp Ile Lys Ala Glu Phe Ser Met Ile Trp Asp Ile
Tyr Val Tyr 530 535 540 Val Leu Lys Ser Trp Val Asn Ala Pro Lys Thr
Phe Phe Glu Ile Ala 545 550 555 560 Val Leu Glu Val Ala Arg Val Trp
Asn Tyr Trp Leu Gly Leu Pro Val 565 570 575 Pro Pro Arg Ser Trp Arg
Ile Gln Leu Pro Lys Arg Pro Thr Pro Pro 580 585 590 Thr Pro Pro Thr
His Glu Glu Leu 595 600 372977DNAAspergillus niger 37gtggttgact
tgggtgactt acgtacctgg cgccaagccc cagaagagac caccttgcga 60agctctcgac
actcttcaat tcattccccc gttcacgaca cctcccaacc cttccctctc
120atcagctccc gggacaggtc gagggctgtt tgctcatctt ctttcccatt
ggatcttgat 180tcttttctcc cctggccatt atggccgaat cacccctcga
tgtcctcttg aagggtaact 240ccggcagaac aacacgcggc cttctgcgga
ttatcattct agctaccatt gccgctgctg 300ctgtgtccag tcgtctgttc
agtgtgatcc gtatgtctct taacttatat gatcgggtca 360attgaattat
cgttactgac agttgccctc taggattcga gagtattatc cacgagtgta
420tgttttgata ccgatcctcc cgtctatacc ttcaagctac cgcggattcg
gcattcgaca 480ccgtgtgcag ccaacttcac ttccaaaacc aatcaatgct
aatgtagctc actcctacag 540tcgacccctg gttcaacttc cgcgcaacaa
aatacctggt ctcccatggc tttgagagct 600tctgggactg gttcgacgac
cgtacgttcc tcttgccaag cctgccttaa cctacatata 660ctgatctaag
atgctgctca ggaacatggc accctctggg acgtgtcact ggtggcacgc
720tataccccgg tctcatggtg accagcggtg ttatttacca cgtcttgcgg
ttcctcacta 780tccctgtcga catccgtaac atctgtgtct tgcttgcccc
gggtttctcc ggtttgaccg 840cgctggcaat gtacttcctg actcgcgaga
tggcgacatc cccctccgct ggtctcctcg 900cggctgcttt catgggtatc
gtccctggat acatctctcg ttccgtcgca ggcagctacg 960ataacgaggc
catcgccatt ttcctgctgg tattcacctt cttcctgtgg atcaaggctg
1020ttaagaatgg ctccatcatg tggggttctc tggcggcctt gttctacggc
tacatggtgt 1080ctgcctgggg tggttatgtc ttcatcacta acttgatccc
tctgcacgtt ttcgttcttc 1140tgtgcatggg cagatacagc tcgcgtatct
atatcagtta taccacttgg tatgctctgg 1200gaactctggc cagtatgcag
attcctttcg tcggattcct gccgattcgc aacagtgacc 1260acatgtccgc
acttggtatg tactctcatt aaccgtagtg aagagcgttt gtactgacct
1320tgccaggtgt cttcggcctc attcagctcg tggcctttgc tgacttcgtc
cggggtttca 1380ttccgggcag gcacttccag agacttctga ccaccatgat
catcgtcgta tttggcatcg 1440ctttcgtcgg actcgtcgtc ctcaccgtgt
ccggagtgat cgccccttgg agtggtcgtt 1500tctactctct gtgggatacc
ggctatgcca agatccacat ccctatcatt gcgtccgtct 1560ccgagcacca
gcccactgct tggcccgcct tcttctttga cctgaacttc ttgatctggc
1620tcttccctgc cggtgtctac atgtgcttcc gggatctcaa ggatgagcac
gtttttgtca 1680tcatctactc ggtgcttgcc agttacttcg caggtgtcat
ggttcgtctg atgttgactt 1740tgacccctat tgtttgtgtt gcggctgctc
tggccctctc caccatcctc gacacgtatg 1800tgttcgcaaa gaatggcccc
aacccccgcg ccaaggcgaa cgacgacacc tcggacggtc 1860ttcgttccac
caggaagccc gatgttggtg tcacgtccta cctgtccaag gctgttatga
1920cttcctccgt tgtcatctat cttcttctct tcgttgcgca ctgcacctgg
gtcacctcga 1980acgcatactc ctccccgtct gtggttctcg caagccgctt
gcctgatgga agccagcaca 2040tcatcgacga ctaccgtgag gcgtactact
ggcttcgtca gaacaccgag cacaacgcca 2100agatcatgtc ctggtgggat
tacggctacc agattggtgg tatggcggac cgccctaccc 2160tggttgacaa
caacacgtgg aacaacaccc acattgccac tgtcggtaag gcgatgagct
2220ctcgtgagga agtcagttac cccatcctcc gtcagcacga tgttgattac
gtgctggtgg 2280tgtttggtgg attgctgggc tactccggtg acgacatcaa
caagttcctg tggatggtcc 2340gtatcgctga aggtatctgg cccgacgagg
tcaaggagcg tgacttcttc actgcccggg 2400gtgaataccg ggttgatgac
ggagccaccc cgactatgcg taacagcttg atgtaagatt 2460tacccctgct
tgccatggca gtgatatgat actaacagcg acccaggtac aaaatgtcct
2520actacaactt caactcgttg ttcggtcccg gccaggccgt tgaccgcgtg
cgtggatcga 2580gactccccgc ggaaggccct cagctgaaca cgctcgagga
ggcattcacc agtgagaact 2640ggatcatccg catctacaag gtcaaggatc
tcgacaacct tggccgtgac cacaacaacg 2700cggtggcctt tgacaagggc
cacaagcgca agcgcgctac caagcgcaag ggccctcgtg 2760tcctgcggac
cgagtaaagg tccaggtgtc gttgatagat accaggttgg gtgtaaaatt
2820gatcccttct tcttcttcat ttcttagcat gtcattttca attccatgtt
cttgtacgtg 2880tcatcaccat ataggcggaa tcatagaagt tgtccatctg
gttagaggct gtagactgta 2940cattttaccc caagcaccaa atatgaacct tgagtga
2977382226DNAAspergillus nigerCDS(1)..(2226) 38atg gcc gaa tca ccc
ctc gat gtc ctc ttg aag ggt aac tcc ggc aga 48Met Ala Glu Ser Pro
Leu Asp Val Leu Leu Lys Gly Asn Ser Gly Arg 1 5 10 15 aca aca cgc
ggc ctt ctg cgg att atc att cta gct acc att gcc gct 96Thr Thr Arg
Gly Leu Leu Arg Ile Ile Ile Leu Ala Thr Ile Ala Ala 20 25 30 gct
gct gtg tcc agt cgt ctg ttc agt gtg atc cga ttc gag agt att 144Ala
Ala Val Ser Ser Arg Leu Phe Ser Val Ile Arg Phe Glu Ser Ile 35 40
45 atc cac gag ttc gac ccc tgg ttc aac ttc cgc gca aca aaa tac ctg
192Ile His Glu Phe Asp Pro Trp Phe Asn Phe Arg Ala Thr Lys Tyr Leu
50 55 60 gtc tcc cat ggc ttt gag agc ttc tgg gac tgg ttc gac gac
cga aca 240Val Ser His Gly Phe Glu Ser Phe Trp Asp Trp Phe Asp Asp
Arg Thr 65 70 75 80 tgg cac cct ctg gga cgt gtc act ggt ggc acg cta
tac ccc ggt ctc 288Trp His Pro Leu Gly Arg Val Thr Gly Gly Thr Leu
Tyr Pro Gly Leu 85 90 95 atg gtg acc agc ggt gtt att tac cac gtc
ttg cgg ttc ctc act atc 336Met Val Thr Ser Gly Val Ile Tyr His Val
Leu Arg Phe Leu Thr Ile 100 105 110 cct gtc gac atc cgt aac atc tgt
gtc ttg ctt gcc ccg ggt ttc tcc 384Pro Val Asp Ile Arg Asn Ile Cys
Val Leu Leu Ala Pro Gly Phe Ser 115 120 125 ggt ttg acc gcg ctg gca
atg tac ttc ctg act cgc gag atg gcg aca 432Gly Leu Thr Ala Leu Ala
Met Tyr Phe Leu Thr Arg Glu Met Ala Thr 130 135 140 tcc ccc tcc gct
ggt ctc ctc gcg gct gct ttc atg ggt atc gtc cct 480Ser Pro Ser Ala
Gly Leu Leu Ala Ala Ala Phe Met Gly Ile Val Pro 145 150 155 160 gga
tac atc tct cgt tcc gtc gca ggc agc tac gat aac gag gcc atc 528Gly
Tyr Ile Ser Arg Ser Val Ala Gly Ser Tyr Asp Asn Glu Ala Ile 165 170
175 gcc att ttc ctg ctg gta ttc acc ttc ttc ctg tgg atc aag gct gtt
576Ala Ile Phe Leu Leu Val Phe Thr Phe Phe Leu Trp Ile Lys Ala Val
180 185 190 aag aat ggc tcc atc atg tgg ggt tct ctg gcg gcc ttg ttc
tac ggc 624Lys Asn Gly Ser Ile Met Trp Gly Ser Leu Ala Ala Leu Phe
Tyr Gly 195 200 205 tac atg gtg tct gcc tgg ggt ggt tat gtc ttc atc
act aac ttg atc 672Tyr Met Val Ser Ala Trp Gly Gly Tyr Val Phe Ile
Thr Asn Leu Ile 210 215 220 cct ctg cac gtt ttc gtt ctt ctg tgc atg
ggc aga tac agc tcg cgt 720Pro Leu His Val Phe Val Leu Leu Cys Met
Gly Arg Tyr Ser Ser Arg 225 230 235 240 atc tat atc agt tat acc act
tgg tat gct ctg gga act ctg gcc agt 768Ile Tyr Ile Ser Tyr Thr Thr
Trp Tyr Ala Leu Gly Thr Leu Ala Ser 245 250 255 atg cag att cct ttc
gtc gga ttc ctg ccg att cgc aac agt gac cac 816Met Gln Ile Pro Phe
Val Gly Phe Leu Pro Ile Arg Asn Ser Asp His 260 265 270 atg tcc gca
ctt ggt gtc ttc ggc ctc att cag ctc gtg gcc ttt gct 864Met Ser Ala
Leu Gly Val Phe Gly Leu Ile Gln Leu Val Ala Phe Ala 275 280 285 gac
ttc gtc cgg ggt ttc att ccg ggc agg cac ttc cag aga ctt ctg 912Asp
Phe Val Arg Gly Phe Ile Pro Gly Arg His Phe Gln Arg Leu Leu 290 295
300 acc acc atg atc atc gtc gta ttt ggc atc gct ttc gtc gga ctc gtc
960Thr Thr Met Ile Ile Val Val Phe Gly Ile Ala Phe Val Gly Leu Val
305 310 315 320 gtc ctc acc gtg tcc gga gtg atc gcc cct tgg agt ggt
cgt ttc tac 1008Val Leu Thr Val Ser Gly Val Ile Ala Pro Trp Ser Gly
Arg Phe Tyr 325 330 335 tct ctg tgg gat acc ggc tat gcc aag atc cac
atc cct atc att gcg 1056Ser Leu Trp Asp Thr Gly Tyr Ala Lys Ile His
Ile Pro Ile Ile Ala 340 345 350 tcc gtc tcc gag cac cag ccc act gct
tgg ccc gcc ttc ttc ttt gac 1104Ser Val Ser Glu His Gln Pro Thr Ala
Trp Pro Ala Phe Phe Phe Asp 355 360 365 ctg aac ttc ttg atc tgg ctc
ttc cct gcc ggt gtc tac atg tgc ttc 1152Leu Asn Phe Leu Ile Trp Leu
Phe Pro Ala Gly Val Tyr Met Cys Phe 370 375 380 cgg gat ctc aag gat
gag cac gtt ttt gtc atc atc tac tcg gtg ctt 1200Arg Asp Leu Lys Asp
Glu His Val Phe Val Ile Ile Tyr Ser Val Leu 385 390 395 400 gcc agt
tac ttc gca ggt gtc atg gtt cgt ctg atg ttg act ttg acc 1248Ala Ser
Tyr Phe Ala Gly Val Met Val Arg Leu Met Leu Thr Leu Thr 405 410 415
cct att gtt tgt gtt gcg gct gct ctg gcc ctc tcc acc atc ctc gac
1296Pro Ile Val Cys Val Ala Ala Ala Leu Ala Leu Ser Thr Ile Leu Asp
420 425 430 acg tat gtg ttc gca aag aat ggc ccc aac ccc cgc gcc aag
gcg aac 1344Thr Tyr Val Phe Ala Lys Asn Gly Pro Asn Pro Arg Ala Lys
Ala Asn 435 440 445 gac gac acc tcg gac ggt ctt cgt tcc acc agg aag
ccc gat gtt ggt 1392Asp Asp Thr Ser Asp Gly Leu Arg Ser Thr Arg Lys
Pro Asp Val Gly 450 455 460 gtc acg tcc tac ctg tcc aag gct gtt atg
act tcc tcc gtt gtc atc 1440Val Thr Ser Tyr Leu Ser Lys Ala Val Met
Thr Ser Ser Val Val Ile 465 470 475 480 tat ctt ctt ctc ttc gtt gcg
cac tgc acc tgg gtc acc tcg aac gca 1488Tyr Leu Leu Leu Phe Val Ala
His Cys Thr Trp Val Thr Ser Asn Ala 485 490 495 tac tcc tcc ccg tct
gtg gtt ctc gca agc cgc ttg cct gat gga agc 1536Tyr Ser Ser Pro Ser
Val Val Leu Ala Ser Arg Leu Pro Asp Gly Ser 500 505 510 cag cac atc
atc gac gac tac cgt gag gcg tac tac tgg ctt cgt cag 1584Gln His Ile
Ile Asp Asp Tyr Arg Glu Ala Tyr Tyr Trp Leu Arg Gln 515 520 525 aac
acc gag cac aac gcc aag atc atg tcc tgg tgg gat tac ggc tac 1632Asn
Thr Glu His Asn Ala Lys Ile Met Ser Trp Trp Asp Tyr Gly Tyr 530 535
540 cag att ggt ggt atg gcg gac cgc cct acc ctg gtt gac aac aac acg
1680Gln Ile Gly Gly Met Ala Asp Arg Pro Thr Leu Val Asp Asn Asn Thr
545 550 555 560 tgg aac aac acc cac att gcc act gtc ggt aag gcg atg
agc tct cgt 1728Trp Asn Asn Thr His Ile Ala Thr Val Gly Lys Ala Met
Ser Ser Arg 565 570 575 gag gaa gtc agt tac ccc atc ctc cgt cag cac
gat gtt gat tac gtg 1776Glu Glu Val Ser Tyr Pro Ile Leu Arg Gln His
Asp Val Asp Tyr Val 580 585 590 ctg gtg gtg ttt ggt gga ttg ctg ggc
tac tcc ggt gac gac atc aac 1824Leu Val Val Phe Gly Gly Leu Leu Gly
Tyr Ser Gly Asp Asp Ile Asn 595 600 605 aag ttc ctg tgg atg gtc cgt
atc gct gaa ggt atc tgg ccc gac gag 1872Lys Phe Leu Trp Met Val Arg
Ile Ala Glu Gly Ile Trp Pro Asp Glu 610 615 620 gtc aag gag cgt gac
ttc ttc act gcc cgg ggt gaa tac cgg gtt gat 1920Val Lys Glu Arg Asp
Phe Phe Thr Ala Arg Gly Glu Tyr Arg Val Asp 625 630 635 640 gac gga
gcc acc ccg act atg cgt aac agc ttg atg tac aaa atg tcc 1968Asp Gly
Ala Thr Pro Thr Met Arg Asn Ser Leu Met Tyr Lys Met Ser 645 650 655
tac tac aac ttc aac tcg ttg ttc ggt ccc ggc cag gcc gtt gac cgc
2016Tyr Tyr Asn Phe Asn Ser Leu Phe Gly Pro Gly Gln Ala Val Asp Arg
660 665 670 gtg cgt gga tcg aga ctc ccc gcg gaa ggc cct cag ctg aac
acg ctc 2064Val Arg Gly Ser Arg Leu Pro Ala Glu Gly Pro Gln Leu Asn
Thr Leu 675 680 685 gag gag gca ttc acc agt gag aac tgg atc atc cgc
atc tac aag gtc 2112Glu Glu Ala Phe Thr Ser Glu Asn Trp Ile Ile Arg
Ile Tyr Lys Val 690 695 700 aag gat ctc gac aac ctt ggc cgt gac cac
aac aac gcg gtg gcc ttt 2160Lys Asp Leu Asp Asn Leu Gly Arg Asp His
Asn Asn Ala Val Ala Phe 705 710 715 720 gac aag ggc cac aag cgc aag
cgc gct acc aag cgc aag ggc cct cgt 2208Asp Lys Gly His Lys Arg Lys
Arg Ala Thr Lys Arg Lys Gly Pro Arg 725 730 735 gtc ctg cgg acc gag
taa 2226Val Leu Arg Thr Glu 740 39741PRTAspergillus niger 39Met Ala
Glu Ser Pro Leu Asp Val Leu Leu Lys Gly Asn Ser Gly Arg 1 5 10 15
Thr Thr Arg Gly Leu Leu Arg Ile Ile Ile Leu Ala Thr Ile Ala Ala 20
25 30 Ala Ala Val Ser Ser Arg Leu Phe Ser Val Ile Arg Phe Glu Ser
Ile 35 40 45 Ile His Glu Phe Asp Pro Trp Phe Asn Phe Arg Ala Thr
Lys Tyr Leu 50 55 60 Val Ser His Gly Phe Glu Ser Phe Trp Asp Trp
Phe Asp Asp Arg Thr 65 70 75 80 Trp His Pro Leu Gly Arg Val Thr Gly
Gly Thr Leu Tyr Pro Gly Leu 85 90 95 Met Val Thr Ser Gly Val Ile
Tyr His Val Leu Arg Phe Leu Thr Ile 100 105 110 Pro Val Asp Ile Arg
Asn Ile Cys Val Leu Leu Ala Pro Gly Phe Ser 115 120 125 Gly Leu Thr
Ala Leu Ala Met Tyr Phe Leu Thr Arg Glu Met Ala Thr 130 135 140 Ser
Pro Ser Ala Gly Leu Leu Ala Ala Ala Phe Met Gly Ile Val Pro 145 150
155 160 Gly Tyr Ile Ser Arg Ser Val Ala Gly Ser Tyr Asp Asn Glu Ala
Ile 165 170 175 Ala Ile Phe Leu Leu Val Phe Thr Phe Phe Leu Trp Ile
Lys Ala Val 180 185 190 Lys Asn Gly Ser Ile Met Trp Gly Ser Leu Ala
Ala Leu Phe Tyr Gly 195 200 205 Tyr Met Val Ser Ala Trp Gly Gly Tyr
Val Phe Ile Thr Asn Leu Ile 210 215 220 Pro Leu His Val Phe Val Leu
Leu Cys Met Gly Arg Tyr Ser Ser Arg 225 230 235 240 Ile Tyr Ile Ser
Tyr Thr Thr Trp Tyr Ala Leu Gly Thr Leu Ala Ser 245 250 255 Met Gln
Ile Pro Phe Val Gly Phe Leu Pro Ile Arg Asn Ser Asp His 260 265 270
Met Ser Ala Leu Gly Val Phe Gly Leu Ile Gln Leu Val Ala Phe Ala 275
280 285 Asp Phe Val Arg Gly Phe Ile Pro Gly Arg His Phe Gln Arg Leu
Leu 290 295 300 Thr Thr Met Ile Ile Val Val Phe Gly Ile Ala Phe Val
Gly Leu Val 305 310 315 320 Val Leu Thr Val Ser Gly Val Ile Ala Pro
Trp Ser Gly Arg Phe Tyr 325 330 335 Ser Leu Trp Asp Thr Gly Tyr Ala
Lys Ile His Ile Pro Ile Ile Ala 340 345 350 Ser Val Ser Glu His Gln
Pro Thr Ala Trp Pro Ala Phe Phe Phe Asp 355 360 365 Leu Asn Phe Leu
Ile Trp Leu Phe Pro Ala Gly Val Tyr Met Cys Phe 370 375 380 Arg Asp
Leu Lys Asp Glu His Val Phe Val Ile Ile Tyr Ser Val Leu 385 390 395
400 Ala Ser Tyr Phe Ala Gly Val Met Val Arg Leu Met Leu Thr Leu Thr
405 410 415 Pro Ile Val Cys Val Ala Ala Ala Leu Ala Leu Ser Thr Ile
Leu Asp 420 425 430 Thr Tyr Val Phe Ala Lys Asn Gly Pro Asn Pro Arg
Ala Lys Ala Asn 435 440 445 Asp Asp Thr Ser Asp Gly Leu Arg Ser Thr
Arg Lys Pro Asp Val Gly 450 455 460 Val Thr Ser Tyr Leu Ser Lys Ala
Val Met Thr Ser Ser Val Val Ile 465 470 475 480 Tyr Leu Leu Leu Phe
Val Ala His Cys Thr Trp Val Thr Ser Asn Ala 485 490
495 Tyr Ser Ser Pro Ser Val Val Leu Ala Ser Arg Leu Pro Asp Gly Ser
500 505 510 Gln His Ile Ile Asp Asp Tyr Arg Glu Ala Tyr Tyr Trp Leu
Arg Gln 515 520 525 Asn Thr Glu His Asn Ala Lys Ile Met Ser Trp Trp
Asp Tyr Gly Tyr 530 535 540 Gln Ile Gly Gly Met Ala Asp Arg Pro Thr
Leu Val Asp Asn Asn Thr 545 550 555 560 Trp Asn Asn Thr His Ile Ala
Thr Val Gly Lys Ala Met Ser Ser Arg 565 570 575 Glu Glu Val Ser Tyr
Pro Ile Leu Arg Gln His Asp Val Asp Tyr Val 580 585 590 Leu Val Val
Phe Gly Gly Leu Leu Gly Tyr Ser Gly Asp Asp Ile Asn 595 600 605 Lys
Phe Leu Trp Met Val Arg Ile Ala Glu Gly Ile Trp Pro Asp Glu 610 615
620 Val Lys Glu Arg Asp Phe Phe Thr Ala Arg Gly Glu Tyr Arg Val Asp
625 630 635 640 Asp Gly Ala Thr Pro Thr Met Arg Asn Ser Leu Met Tyr
Lys Met Ser 645 650 655 Tyr Tyr Asn Phe Asn Ser Leu Phe Gly Pro Gly
Gln Ala Val Asp Arg 660 665 670 Val Arg Gly Ser Arg Leu Pro Ala Glu
Gly Pro Gln Leu Asn Thr Leu 675 680 685 Glu Glu Ala Phe Thr Ser Glu
Asn Trp Ile Ile Arg Ile Tyr Lys Val 690 695 700 Lys Asp Leu Asp Asn
Leu Gly Arg Asp His Asn Asn Ala Val Ala Phe 705 710 715 720 Asp Lys
Gly His Lys Arg Lys Arg Ala Thr Lys Arg Lys Gly Pro Arg 725 730 735
Val Leu Arg Thr Glu 740 401546DNAAspergillus niger 40ttaccaagtg
tcctctttga cccgctcggt ctccgcagcg cttccgcctt ccacgccggg 60agctcatacg
actatatcta cactccgccc agcaacaacc ccttccctcg ctgaacggac
120aggaccattt gctattgaca agtaacattg tcaatcgccc tgcttctact
tctccctaaa 180ccaaaaccac accatccatc atggtccgtc tcagcaatct
cgtgagctgc ctcggcctgg 240cctccgcggt caccgcagca gtggtcgatc
tcgtccccaa gaacttcgac gacgtcgtcc 300tcaagtccgg caagcccgct
ctggttgaat tcttcgctcc ctggtgcggc cactgcaaga 360acctcgcgcc
cgtgtatgaa gagctgggcc aggcattcgc ccatgcctcc gacaaggtca
420ccgtcggcaa ggttgatgcg gacgagcacc gcgacttggg ccgcaagttc
ggtgtccagg 480gattccccac gctaaagtgg ttcgacggaa agagtgacga
gccggaggat tacaagggtg 540gtcgtgattt ggagagtctg tcttcgttca
tctctgagaa gacgggcgtc aagccccgtg 600gtcctaagaa ggagcccagc
aaggtggaga tgctgaacga cgcgactttc aagggcgctg 660ttggtggcga
taatgatgtt ctggttgcgt tcaccgcgcc gtggtgtgga cgtgagtatc
720ctcgtttcat cgttcccgct ctagaagcaa atcactaact acggcctttt
aaaacagact 780gcaagaacct cgctcctacc tgggaagccc tggccaacga
cttcgtcctc gagcccaacg 840ttgtgatcgc caaggtcgac gccgacgctg
agaacggcaa ggccaccgcc agagagcagg 900gcgtgtccgg ataccccacc
atcaagttct tccccaaggg ctctacggaa tctgttccct 960atgagggtgc
ccgctctgag caggccttca ttgacttcct caacgagaag accggcaccc
1020accgtaccgt tggcggcgga ctcgacacca aggccggcac cattgctagc
ctggacgagc 1080tgattgccag cacttctgct gctgacctgg ccgccgcagt
caagaaggct gctacggagc 1140ttaaggacaa gtacgctcag tactacgtca
aggttgcgga caagctgagc cagaacgccg 1200agtatgccgc taaggagctt
gctcgtctgg agaagatcct ggccaagggt ggatcggccc 1260ctgagaaggt
ggatgacctt atctcccgca gcaacatcct tcgcaagttt gttggtgagg
1320agaaggaggc caaggatgag ctgtagatat tgtatggatt atgacttgtt
tagctagggt 1380ataggcacct agtttctgtt actctgtatg atatcaagag
gcagttatga gaatgctatc 1440gatgcgaaca gtaaaccatc catttcccat
tcccatgtat gtatacacaa gaacataaga 1500gtatatagta gatgtaaatt
gacagtaaaa agcgtatctt cacatt 1546411080DNAAspergillus
nigerCDS(1)..(1080) 41atg gtc cgt ctc agc aat ctc gtg agc tgc ctc
ggc ctg gcc tcc gcg 48Met Val Arg Leu Ser Asn Leu Val Ser Cys Leu
Gly Leu Ala Ser Ala 1 5 10 15 gtc acc gca gca gtg gtc gat ctc gtc
ccc aag aac ttc gac gac gtc 96Val Thr Ala Ala Val Val Asp Leu Val
Pro Lys Asn Phe Asp Asp Val 20 25 30 gtc ctc aag tcc ggc aag ccc
gct ctg gtt gaa ttc ttc gct ccc tgg 144Val Leu Lys Ser Gly Lys Pro
Ala Leu Val Glu Phe Phe Ala Pro Trp 35 40 45 tgc ggc cac tgc aag
aac ctc gcg ccc gtg tat gaa gag ctg ggc cag 192Cys Gly His Cys Lys
Asn Leu Ala Pro Val Tyr Glu Glu Leu Gly Gln 50 55 60 gca ttc gcc
cat gcc tcc gac aag gtc acc gtc ggc aag gtt gat gcg 240Ala Phe Ala
His Ala Ser Asp Lys Val Thr Val Gly Lys Val Asp Ala 65 70 75 80 gac
gag cac cgc gac ttg ggc cgc aag ttc ggt gtc cag gga ttc ccc 288Asp
Glu His Arg Asp Leu Gly Arg Lys Phe Gly Val Gln Gly Phe Pro 85 90
95 acg cta aag tgg ttc gac gga aag agt gac gag ccg gag gat tac aag
336Thr Leu Lys Trp Phe Asp Gly Lys Ser Asp Glu Pro Glu Asp Tyr Lys
100 105 110 ggt ggt cgt gat ttg gag agt ctg tct tcg ttc atc tct gag
aag acg 384Gly Gly Arg Asp Leu Glu Ser Leu Ser Ser Phe Ile Ser Glu
Lys Thr 115 120 125 ggc gtc aag ccc cgt ggt cct aag aag gag ccc agc
aag gtg gag atg 432Gly Val Lys Pro Arg Gly Pro Lys Lys Glu Pro Ser
Lys Val Glu Met 130 135 140 ctg aac gac gcg act ttc aag ggc gct gtt
ggt ggc gat aat gat gtt 480Leu Asn Asp Ala Thr Phe Lys Gly Ala Val
Gly Gly Asp Asn Asp Val 145 150 155 160 ctg gtt gcg ttc acc gcg ccg
tgg tgt gga cac tgc aag aac ctc gct 528Leu Val Ala Phe Thr Ala Pro
Trp Cys Gly His Cys Lys Asn Leu Ala 165 170 175 cct acc tgg gaa gcc
ctg gcc aac gac ttc gtc ctc gag ccc aac gtt 576Pro Thr Trp Glu Ala
Leu Ala Asn Asp Phe Val Leu Glu Pro Asn Val 180 185 190 gtg atc gcc
aag gtc gac gcc gac gct gag aac ggc aag gcc acc gcc 624Val Ile Ala
Lys Val Asp Ala Asp Ala Glu Asn Gly Lys Ala Thr Ala 195 200 205 aga
gag cag ggc gtg tcc gga tac ccc acc atc aag ttc ttc ccc aag 672Arg
Glu Gln Gly Val Ser Gly Tyr Pro Thr Ile Lys Phe Phe Pro Lys 210 215
220 ggc tct acg gaa tct gtt ccc tat gag ggt gcc cgc tct gag cag gcc
720Gly Ser Thr Glu Ser Val Pro Tyr Glu Gly Ala Arg Ser Glu Gln Ala
225 230 235 240 ttc att gac ttc ctc aac gag aag acc ggc acc cac cgt
acc gtt ggc 768Phe Ile Asp Phe Leu Asn Glu Lys Thr Gly Thr His Arg
Thr Val Gly 245 250 255 ggc gga ctc gac acc aag gcc ggc acc att gct
agc ctg gac gag ctg 816Gly Gly Leu Asp Thr Lys Ala Gly Thr Ile Ala
Ser Leu Asp Glu Leu 260 265 270 att gcc agc act tct gct gct gac ctg
gcc gcc gca gtc aag aag gct 864Ile Ala Ser Thr Ser Ala Ala Asp Leu
Ala Ala Ala Val Lys Lys Ala 275 280 285 gct acg gag ctt aag gac aag
tac gct cag tac tac gtc aag gtt gcg 912Ala Thr Glu Leu Lys Asp Lys
Tyr Ala Gln Tyr Tyr Val Lys Val Ala 290 295 300 gac aag ctg agc cag
aac gcc gag tat gcc gct aag gag ctt gct cgt 960Asp Lys Leu Ser Gln
Asn Ala Glu Tyr Ala Ala Lys Glu Leu Ala Arg 305 310 315 320 ctg gag
aag atc ctg gcc aag ggt gga tcg gcc cct gag aag gtg gat 1008Leu Glu
Lys Ile Leu Ala Lys Gly Gly Ser Ala Pro Glu Lys Val Asp 325 330 335
gac ctt atc tcc cgc agc aac atc ctt cgc aag ttt gtt ggt gag gag
1056Asp Leu Ile Ser Arg Ser Asn Ile Leu Arg Lys Phe Val Gly Glu Glu
340 345 350 aag gag gcc aag gat gag ctg tag 1080Lys Glu Ala Lys Asp
Glu Leu 355 42359PRTAspergillus niger 42Met Val Arg Leu Ser Asn Leu
Val Ser Cys Leu Gly Leu Ala Ser Ala 1 5 10 15 Val Thr Ala Ala Val
Val Asp Leu Val Pro Lys Asn Phe Asp Asp Val 20 25 30 Val Leu Lys
Ser Gly Lys Pro Ala Leu Val Glu Phe Phe Ala Pro Trp 35 40 45 Cys
Gly His Cys Lys Asn Leu Ala Pro Val Tyr Glu Glu Leu Gly Gln 50 55
60 Ala Phe Ala His Ala Ser Asp Lys Val Thr Val Gly Lys Val Asp Ala
65 70 75 80 Asp Glu His Arg Asp Leu Gly Arg Lys Phe Gly Val Gln Gly
Phe Pro 85 90 95 Thr Leu Lys Trp Phe Asp Gly Lys Ser Asp Glu Pro
Glu Asp Tyr Lys 100 105 110 Gly Gly Arg Asp Leu Glu Ser Leu Ser Ser
Phe Ile Ser Glu Lys Thr 115 120 125 Gly Val Lys Pro Arg Gly Pro Lys
Lys Glu Pro Ser Lys Val Glu Met 130 135 140 Leu Asn Asp Ala Thr Phe
Lys Gly Ala Val Gly Gly Asp Asn Asp Val 145 150 155 160 Leu Val Ala
Phe Thr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Ala 165 170 175 Pro
Thr Trp Glu Ala Leu Ala Asn Asp Phe Val Leu Glu Pro Asn Val 180 185
190 Val Ile Ala Lys Val Asp Ala Asp Ala Glu Asn Gly Lys Ala Thr Ala
195 200 205 Arg Glu Gln Gly Val Ser Gly Tyr Pro Thr Ile Lys Phe Phe
Pro Lys 210 215 220 Gly Ser Thr Glu Ser Val Pro Tyr Glu Gly Ala Arg
Ser Glu Gln Ala 225 230 235 240 Phe Ile Asp Phe Leu Asn Glu Lys Thr
Gly Thr His Arg Thr Val Gly 245 250 255 Gly Gly Leu Asp Thr Lys Ala
Gly Thr Ile Ala Ser Leu Asp Glu Leu 260 265 270 Ile Ala Ser Thr Ser
Ala Ala Asp Leu Ala Ala Ala Val Lys Lys Ala 275 280 285 Ala Thr Glu
Leu Lys Asp Lys Tyr Ala Gln Tyr Tyr Val Lys Val Ala 290 295 300 Asp
Lys Leu Ser Gln Asn Ala Glu Tyr Ala Ala Lys Glu Leu Ala Arg 305 310
315 320 Leu Glu Lys Ile Leu Ala Lys Gly Gly Ser Ala Pro Glu Lys Val
Asp 325 330 335 Asp Leu Ile Ser Arg Ser Asn Ile Leu Arg Lys Phe Val
Gly Glu Glu 340 345 350 Lys Glu Ala Lys Asp Glu Leu 355
432673DNAAspergillus niger 43gccaagaacg tcggcgaaat gaagctccgc
aacgccaggt ggcccgttcc gcatcggggc 60cgagcaagca actccccccg agtctcaagt
gctcatcttc actatcagct cctctcccct 120ctcttacttt atcggaagct
cgagcacaga gtcgccatgc gcctctcact gttcacttct 180attcaacttt
ctcacacaac atgaagaact ggtggctgtg gcgtttcctg ccgttggcgc
240ttcgtgagtc ctcttactgt ggagcttagc cgcatcacgc gatagcaact
gacctccaag 300catcactttc cagtgcttct gcaggcgctt gcggatgaat
acaatggaca gcacgacaca 360caaaaaccct taacagatgt tgttcctgaa
tcatatgcac atgctgagtc ctcgagcggg 420cccgagggct ctgacgttct
accgggacac ggtaagcggc cctgtgcatg acgccagcgc 480acccatcctt
gctaacaact agtgatttga tgtgccaata gtacacgtcg aaaatgccct
540tcaaatcctc cgagagagca agatccccat tgtcgctcac gagaaaccgt
ccggccttct 600ggggtacacc tggcattacg cccaagaagc cttccgactc
ctatttatga atggaccaca 660gccggatgga acacacaagc aaaagctcga
tccaaatgtt gcaaaggctg cgaatgaact 720taaggttgcg gcgcaagaac
accaaaaccc cgatgcaatg ttcctcttag cggaaatgaa 780cttctacggc
aacttcaccc acccgagaga tttcaagcag gcgtttcatt ggtaccaaac
840tctggcgtca tcgactggaa acagtacggc gcaatatatg cttgggttta
tgtatgcaac 900gggtgtcggg ggtgcggtgg agcgcgacca ggctaaggcc
ctgttatacc acacctttgc 960ggctgaagcg ggcaatacga agtcggaaat
gaccctcgcg tatcgctacc acgctggaat 1020tggggctcct agagattgcg
atcaagcgac ttactactat aagaaggtgg ctgataaggc 1080tattgaatac
ttccgatcgg gaccgcccgg tggccataac atgatccgcg agtcctaccg
1140ttgggcggac gaagagggtg gtgtttatgg tgaaggcgct agtgtatcga
ctgccgtacg 1200cgatggaacg cattcgagca cggaagccag cttggaagac
gtcttggagt acctggattt 1260gatgtcgaga aagggcgaac tgaaggctac
tttcagcttg ggcaagatgc attacgaagg 1320gggccgcggc ttgcctcgga
atttccgaaa gtcgatgaat tacttccgac aggtcgccaa 1380gcggtattgg
aataaagatg gatcggtgaa ccccaaccat cctgttggtg ttgaaaagct
1440cgcttcgaaa gcagcaggcc atattggcat gatgtacctg cgtggcgagg
gggtggaaca 1500gaactttgca accgctcaga cttggtttag gcgtggactc
gcgaatggtg atgctctctg 1560tcagcatgag ctaggactga tgtacctgca
tggctatggt gtgacaccag atgcgttcag 1620agctgcatca caatttaagg
ctgcggctga gcaggacttc ccggcggctg aaacgagact 1680gggtgccctg
tttctagacc agggtgatgt ccagaccgcc acccgttatt tcgaactggc
1740tgcgcgctgg ggatggatgg aggccttcta ctacctggca gaattgtcca
acaatggggt 1800tggtcggaaa cgacactgcg ggatggccgc gtcttactac
aagatggtcg cagagcgggc 1860ggaagtcatc cattcatctt ttgaggaagc
aaatacggcg tatgagaacg gagacaagga 1920acgggctctc attccggcgc
tgatggctgc ggagcagggt tacgagcatg cacagtccaa 1980tgttgcgttc
ctgctggacg agcagcggtc cttattcgcc attgacacta tcctcccagg
2040agctaagaag agcagaccgg ctttgctgcg gaatgcagcg ctggctctta
tctattggac 2100acgttccgcc aaacaggcga acatcgactc cttgctcaag
atgggcgatt actacctggc 2160gggcatggga attgctgcgg atgcggagaa
ggcctcgacc tgctaccaca cagcagccga 2220agtgcactat agcgcacagg
cgtactggaa tctgggatgg atgcatgaga atggcgttgc 2280ggtggaccaa
gacttccaca tggccaagcg atactacgat ctagcgctgg agactagctc
2340cgaggcatat ctgcccgtga agctcagtct gcttaaactg cggatgcggg
gatactggaa 2400ctggctcacg aacggagaca tcaaccctat ccgagaggaa
gaaggtaagg aaccccaaca 2460tccttttcgc tgagaaaccc gaacaatcac
acttacacac taatgcagaa gtgaggtcgc 2520atcgcacctt gaaggaattc
atcgccactt ttatccagaa caacgaggaa gaagaggccg 2580ccttccgcgc
ccagatgtac aaacaggacg aggaggacga actcatgtcg aataatcgcc
2640ttgacgacca ccgcgaagac ggctactatg atg 2673442070DNAAspergillus
nigerCDS(1)..(2070) 44atg aag aac tgg tgg ctg tgg cgt ttc ctg ccg
ttg gcg ctt cat gtt 48Met Lys Asn Trp Trp Leu Trp Arg Phe Leu Pro
Leu Ala Leu His Val 1 5 10 15 gtt cct gaa tca tat gca cat gct gag
tcc tcg agc ggg ccc gag ggc 96Val Pro Glu Ser Tyr Ala His Ala Glu
Ser Ser Ser Gly Pro Glu Gly 20 25 30 tct gac gtt cta ccg gga cac
gta cac gtc gaa aat gcc ctt caa atc 144Ser Asp Val Leu Pro Gly His
Val His Val Glu Asn Ala Leu Gln Ile 35 40 45 ctc cga gag agc aag
atc ccc att gtc gct cac gag aaa ccg tcc ggc 192Leu Arg Glu Ser Lys
Ile Pro Ile Val Ala His Glu Lys Pro Ser Gly 50 55 60 ctt ctg ggg
tac acc tgg cat tac gcc caa gaa gcc ttc cga ctc cta 240Leu Leu Gly
Tyr Thr Trp His Tyr Ala Gln Glu Ala Phe Arg Leu Leu 65 70 75 80 ttt
atg aat gga cca cag ccg gat gga aca cac aag caa aag ctc gat 288Phe
Met Asn Gly Pro Gln Pro Asp Gly Thr His Lys Gln Lys Leu Asp 85 90
95 cca aat gtt gca aag gct gcg aat gaa ctt aag gtt gcg gcg caa gaa
336Pro Asn Val Ala Lys Ala Ala Asn Glu Leu Lys Val Ala Ala Gln Glu
100 105 110 cac caa aac ccc gat gca atg ttc ctc tta gcg gaa atg aac
ttc tac 384His Gln Asn Pro Asp Ala Met Phe Leu Leu Ala Glu Met Asn
Phe Tyr 115 120 125 ggc aac ttc acc cac ccg aga gat ttc aag cag gcg
ttt cat tgg tac 432Gly Asn Phe Thr His Pro Arg Asp Phe Lys Gln Ala
Phe His Trp Tyr 130 135 140 caa act ctg gcg tca tcg act gga aac agt
acg gcg caa tat atg ctt 480Gln Thr Leu Ala Ser Ser Thr Gly Asn Ser
Thr Ala Gln Tyr Met Leu 145 150 155 160 ggg ttt atg tat gca acg ggt
gtc ggg ggt gcg gtg gag cgc gac cag 528Gly Phe Met Tyr Ala Thr Gly
Val Gly Gly Ala Val Glu Arg Asp Gln 165 170 175 gct aag gcc ctg tta
tac cac acc ttt gcg gct gaa gcg ggc aat acg 576Ala Lys Ala Leu Leu
Tyr His Thr Phe Ala Ala Glu Ala Gly Asn Thr 180 185 190 aag tcg gaa
atg acc ctc gcg tat cgc tac cac gct gga att ggg gct 624Lys Ser Glu
Met Thr Leu Ala Tyr Arg Tyr His Ala Gly Ile Gly Ala 195 200 205 cct
aga gat tgc gat caa gcg act tac tac tat aag aag gtg gct gat 672Pro
Arg Asp Cys Asp Gln Ala Thr Tyr Tyr Tyr Lys Lys Val Ala Asp 210 215
220 aag gct att gaa tac ttc cga tcg gga ccg ccc ggt ggc cat aac atg
720Lys Ala Ile Glu Tyr Phe Arg Ser Gly Pro Pro Gly Gly His Asn Met
225 230 235 240 atc cgc gag tcc tac cgt tgg gcg gac gaa gag ggt ggt
gtt tat ggt 768Ile Arg Glu Ser Tyr Arg Trp Ala Asp Glu Glu Gly Gly
Val Tyr Gly 245 250 255 gaa ggc gct agt gta tcg act gcc gta cgc gat
gga acg cat tcg agc 816Glu Gly Ala Ser Val Ser Thr Ala Val Arg Asp
Gly Thr His Ser Ser 260 265 270 acg gaa gcc agc ttg gaa gac gtc ttg
gag tac ctg gat ttg atg tcg 864Thr Glu Ala Ser Leu Glu Asp Val Leu
Glu Tyr Leu Asp Leu Met Ser 275 280 285
aga aag ggc gaa ctg aag gct act ttc agc ttg ggc aag atg cat tac
912Arg Lys Gly Glu Leu Lys Ala Thr Phe Ser Leu Gly Lys Met His Tyr
290 295 300 gaa ggg ggc cgc ggc ttg cct cgg aat ttc cga aag tcg atg
aat tac 960Glu Gly Gly Arg Gly Leu Pro Arg Asn Phe Arg Lys Ser Met
Asn Tyr 305 310 315 320 ttc cga cag gtc gcc aag cgg tat tgg aat aaa
gat gga tcg gtg aac 1008Phe Arg Gln Val Ala Lys Arg Tyr Trp Asn Lys
Asp Gly Ser Val Asn 325 330 335 ccc aac cat cct gtt ggt gtt gaa aag
ctc gct tcg aaa gca gca ggc 1056Pro Asn His Pro Val Gly Val Glu Lys
Leu Ala Ser Lys Ala Ala Gly 340 345 350 cat att ggc atg atg tac ctg
cgt ggc gag ggg gtg gaa cag aac ttt 1104His Ile Gly Met Met Tyr Leu
Arg Gly Glu Gly Val Glu Gln Asn Phe 355 360 365 gca acc gct cag act
tgg ttt agg cgt gga ctc gcg aat ggt gat gct 1152Ala Thr Ala Gln Thr
Trp Phe Arg Arg Gly Leu Ala Asn Gly Asp Ala 370 375 380 ctc tgt cag
cat gag cta gga ctg atg tac ctg cat ggc tat ggt gtg 1200Leu Cys Gln
His Glu Leu Gly Leu Met Tyr Leu His Gly Tyr Gly Val 385 390 395 400
aca cca gat gcg ttc aga gct gca tca caa ttt aag gct gcg gct gag
1248Thr Pro Asp Ala Phe Arg Ala Ala Ser Gln Phe Lys Ala Ala Ala Glu
405 410 415 cag gac ttc ccg gcg gct gaa acg aga ctg ggt gcc ctg ttt
cta gac 1296Gln Asp Phe Pro Ala Ala Glu Thr Arg Leu Gly Ala Leu Phe
Leu Asp 420 425 430 cag ggt gat gtc cag acc gcc acc cgt tat ttc gaa
ctg gct gcg cgc 1344Gln Gly Asp Val Gln Thr Ala Thr Arg Tyr Phe Glu
Leu Ala Ala Arg 435 440 445 tgg gga tgg atg gag gcc ttc tac tac ctg
gca gaa ttg tcc aac aat 1392Trp Gly Trp Met Glu Ala Phe Tyr Tyr Leu
Ala Glu Leu Ser Asn Asn 450 455 460 ggg gtt ggt cgg aaa cga cac tgc
ggg atg gcc gcg tct tac tac aag 1440Gly Val Gly Arg Lys Arg His Cys
Gly Met Ala Ala Ser Tyr Tyr Lys 465 470 475 480 atg gtc gca gag cgg
gcg gaa gtc atc cat tca tct ttt gag gaa gca 1488Met Val Ala Glu Arg
Ala Glu Val Ile His Ser Ser Phe Glu Glu Ala 485 490 495 aat acg gcg
tat gag aac gga gac aag gaa cgg gct ctc att ccg gcg 1536Asn Thr Ala
Tyr Glu Asn Gly Asp Lys Glu Arg Ala Leu Ile Pro Ala 500 505 510 ctg
atg gct gcg gag cag ggt tac gag cat gca cag tcc aat gtt gcg 1584Leu
Met Ala Ala Glu Gln Gly Tyr Glu His Ala Gln Ser Asn Val Ala 515 520
525 ttc ctg ctg gac gag cag cgg tcc tta ttc gcc att gac act atc ctc
1632Phe Leu Leu Asp Glu Gln Arg Ser Leu Phe Ala Ile Asp Thr Ile Leu
530 535 540 cca gga gct aag aag agc aga ccg gct ttg ctg cgg aat gca
gcg ctg 1680Pro Gly Ala Lys Lys Ser Arg Pro Ala Leu Leu Arg Asn Ala
Ala Leu 545 550 555 560 gct ctt atc tat tgg aca cgt tcc gcc aaa cag
gcg aac atc gac tcc 1728Ala Leu Ile Tyr Trp Thr Arg Ser Ala Lys Gln
Ala Asn Ile Asp Ser 565 570 575 ttg ctc aag atg ggc gat tac tac ctg
gcg ggc atg gga att gct gcg 1776Leu Leu Lys Met Gly Asp Tyr Tyr Leu
Ala Gly Met Gly Ile Ala Ala 580 585 590 gat gcg gag aag gcc tcg acc
tgc tac cac aca gca gcc gaa gtg cac 1824Asp Ala Glu Lys Ala Ser Thr
Cys Tyr His Thr Ala Ala Glu Val His 595 600 605 tat agc gca cag gcg
tac tgg aat ctg gga tgg atg cat gag aat ggc 1872Tyr Ser Ala Gln Ala
Tyr Trp Asn Leu Gly Trp Met His Glu Asn Gly 610 615 620 gtt gcg gtg
gac caa gac ttc cac atg gcc aag cga tac tac gat cta 1920Val Ala Val
Asp Gln Asp Phe His Met Ala Lys Arg Tyr Tyr Asp Leu 625 630 635 640
gcg ctg gag act agc tcc gag gca tat ctg ccc gtg aag ctc agt ctg
1968Ala Leu Glu Thr Ser Ser Glu Ala Tyr Leu Pro Val Lys Leu Ser Leu
645 650 655 ctt aaa ctg cgg atg cgg gga tac tgg aac tgg ctc acg aac
gga gac 2016Leu Lys Leu Arg Met Arg Gly Tyr Trp Asn Trp Leu Thr Asn
Gly Asp 660 665 670 atc aac cct atc cga gag gaa gaa ggt aag gaa ccc
caa cat cct ttt 2064Ile Asn Pro Ile Arg Glu Glu Glu Gly Lys Glu Pro
Gln His Pro Phe 675 680 685 cgc tga 2070Arg 45689PRTAspergillus
niger 45Met Lys Asn Trp Trp Leu Trp Arg Phe Leu Pro Leu Ala Leu His
Val 1 5 10 15 Val Pro Glu Ser Tyr Ala His Ala Glu Ser Ser Ser Gly
Pro Glu Gly 20 25 30 Ser Asp Val Leu Pro Gly His Val His Val Glu
Asn Ala Leu Gln Ile 35 40 45 Leu Arg Glu Ser Lys Ile Pro Ile Val
Ala His Glu Lys Pro Ser Gly 50 55 60 Leu Leu Gly Tyr Thr Trp His
Tyr Ala Gln Glu Ala Phe Arg Leu Leu 65 70 75 80 Phe Met Asn Gly Pro
Gln Pro Asp Gly Thr His Lys Gln Lys Leu Asp 85 90 95 Pro Asn Val
Ala Lys Ala Ala Asn Glu Leu Lys Val Ala Ala Gln Glu 100 105 110 His
Gln Asn Pro Asp Ala Met Phe Leu Leu Ala Glu Met Asn Phe Tyr 115 120
125 Gly Asn Phe Thr His Pro Arg Asp Phe Lys Gln Ala Phe His Trp Tyr
130 135 140 Gln Thr Leu Ala Ser Ser Thr Gly Asn Ser Thr Ala Gln Tyr
Met Leu 145 150 155 160 Gly Phe Met Tyr Ala Thr Gly Val Gly Gly Ala
Val Glu Arg Asp Gln 165 170 175 Ala Lys Ala Leu Leu Tyr His Thr Phe
Ala Ala Glu Ala Gly Asn Thr 180 185 190 Lys Ser Glu Met Thr Leu Ala
Tyr Arg Tyr His Ala Gly Ile Gly Ala 195 200 205 Pro Arg Asp Cys Asp
Gln Ala Thr Tyr Tyr Tyr Lys Lys Val Ala Asp 210 215 220 Lys Ala Ile
Glu Tyr Phe Arg Ser Gly Pro Pro Gly Gly His Asn Met 225 230 235 240
Ile Arg Glu Ser Tyr Arg Trp Ala Asp Glu Glu Gly Gly Val Tyr Gly 245
250 255 Glu Gly Ala Ser Val Ser Thr Ala Val Arg Asp Gly Thr His Ser
Ser 260 265 270 Thr Glu Ala Ser Leu Glu Asp Val Leu Glu Tyr Leu Asp
Leu Met Ser 275 280 285 Arg Lys Gly Glu Leu Lys Ala Thr Phe Ser Leu
Gly Lys Met His Tyr 290 295 300 Glu Gly Gly Arg Gly Leu Pro Arg Asn
Phe Arg Lys Ser Met Asn Tyr 305 310 315 320 Phe Arg Gln Val Ala Lys
Arg Tyr Trp Asn Lys Asp Gly Ser Val Asn 325 330 335 Pro Asn His Pro
Val Gly Val Glu Lys Leu Ala Ser Lys Ala Ala Gly 340 345 350 His Ile
Gly Met Met Tyr Leu Arg Gly Glu Gly Val Glu Gln Asn Phe 355 360 365
Ala Thr Ala Gln Thr Trp Phe Arg Arg Gly Leu Ala Asn Gly Asp Ala 370
375 380 Leu Cys Gln His Glu Leu Gly Leu Met Tyr Leu His Gly Tyr Gly
Val 385 390 395 400 Thr Pro Asp Ala Phe Arg Ala Ala Ser Gln Phe Lys
Ala Ala Ala Glu 405 410 415 Gln Asp Phe Pro Ala Ala Glu Thr Arg Leu
Gly Ala Leu Phe Leu Asp 420 425 430 Gln Gly Asp Val Gln Thr Ala Thr
Arg Tyr Phe Glu Leu Ala Ala Arg 435 440 445 Trp Gly Trp Met Glu Ala
Phe Tyr Tyr Leu Ala Glu Leu Ser Asn Asn 450 455 460 Gly Val Gly Arg
Lys Arg His Cys Gly Met Ala Ala Ser Tyr Tyr Lys 465 470 475 480 Met
Val Ala Glu Arg Ala Glu Val Ile His Ser Ser Phe Glu Glu Ala 485 490
495 Asn Thr Ala Tyr Glu Asn Gly Asp Lys Glu Arg Ala Leu Ile Pro Ala
500 505 510 Leu Met Ala Ala Glu Gln Gly Tyr Glu His Ala Gln Ser Asn
Val Ala 515 520 525 Phe Leu Leu Asp Glu Gln Arg Ser Leu Phe Ala Ile
Asp Thr Ile Leu 530 535 540 Pro Gly Ala Lys Lys Ser Arg Pro Ala Leu
Leu Arg Asn Ala Ala Leu 545 550 555 560 Ala Leu Ile Tyr Trp Thr Arg
Ser Ala Lys Gln Ala Asn Ile Asp Ser 565 570 575 Leu Leu Lys Met Gly
Asp Tyr Tyr Leu Ala Gly Met Gly Ile Ala Ala 580 585 590 Asp Ala Glu
Lys Ala Ser Thr Cys Tyr His Thr Ala Ala Glu Val His 595 600 605 Tyr
Ser Ala Gln Ala Tyr Trp Asn Leu Gly Trp Met His Glu Asn Gly 610 615
620 Val Ala Val Asp Gln Asp Phe His Met Ala Lys Arg Tyr Tyr Asp Leu
625 630 635 640 Ala Leu Glu Thr Ser Ser Glu Ala Tyr Leu Pro Val Lys
Leu Ser Leu 645 650 655 Leu Lys Leu Arg Met Arg Gly Tyr Trp Asn Trp
Leu Thr Asn Gly Asp 660 665 670 Ile Asn Pro Ile Arg Glu Glu Glu Gly
Lys Glu Pro Gln His Pro Phe 675 680 685 Arg 462326DNAAspergillus
niger 46ctgtctggtt catgcacatc acttactagt tagcacttgt tcatattgtc
attgtgtcaa 60ttttactcga ctgatcccaa ctttatcatt ctcctctgct ttacgccatt
gtttctcttg 120cagtgagcat tgcgacttcg attatgcgcc cgtgattgtc
tacgcccaac atccctccgc 180aaggacagaa caatcccagg atgaccgcgt
cttcagaaac ccagtccgct ctggcggaat 240ctccacagag catagtatta
catgtgctat gtccatcttt acctcctcct aaccgattca 300ctctccacga
catctctcca tccaccacca tctccactct caaagctcga atcgcccaga
360ccattccgag tgaaccatcc cctgaaactc agaggctgat ataccggggg
aagcccctta 420cgaacgacgc cgtggcgcta aatgatgtgt tagagtcatc
aaatgtgcgt atgatcttat 480tcctatgccc ccttgtagtc ggcagatact
aacagtgata cttgacccag gataccgagt 540attccatcca cctcgtcctt
cctcctgccc cagttcccca tgcttcaact tctgccagag 600ctcctgctcc
aatgccgcgg ggagcttcag gtaaccccgc gcctcagagt ccattctcat
660cgaaccgatt cacgccgcaa cacctgcctc acggacaaga gatcaggtat
cgaggtcccg 720cattgcccgc tgttccccat gaggcagaga tcggactcgc
cttgaggcgg aatatcgagg 780ctattcgtcg acagattgat atgcaggaac
ggggcgggcc gttgggaggc gtcgcggcag 840gcaccgcggg ggctacttcc
cactcgacca catccacgac tacgacagct tcgttcgctc 900agcaacctgc
atggccacac gtaacacctg gtctatcgca cccaggacat tcgtccatct
960catctgattt cacaatggct tccggctcat cgggaacagc caatgtccat
agcaacctcc 1020ccgaagaagt ccgattgcgc ctacaaatac tcagaaatca
gattgcgttt ggcgaagagc 1080aactgaaccg gggggttgcg cccccaatgg
accatataat tcgcatacgt acacaattgt 1140tcgctttgct cgacgaccaa
tatcagaacc cacatgctga gcgcgacggc tcgattgaat 1200ctttgctcac
tcgcgtcttt aatatctata cccgcgctga tcagctccgc gtctcacaag
1260ctagaaccat gcccacacct gttctatctg gacctcccaa tcccgcacca
gggcaggctc 1320ctctgtacct tctctcgtca ccaaacggct atcaagccct
ggttgcatct ccccgcggtg 1380cagaaacgat gcagtcttct ctcgatacac
tccgagccat gcactccccg accggagcct 1440ctgcgcctcg tacaggtgct
ccaccggaga ttcacaatgc gaacgcagtt gtcatggaga 1500acattgtccg
acaggccgta ctcaaccaac gcatcgaaaa caacgggcaa ttgagcttca
1560cacgcaatct ccgacgcatg tggctatttg tgcgcttgta tttcttctgc
tacatgttca 1620gcgaaccggg cacatggtct cgcgtggtgt atgtaaccct
agccgtcctt gtctcactcc 1680tgtcagaaac cgggatccca cagcagttgt
accgaatgct tgtggcgcca gtgcaacgac 1740acctggaagg actggttcat
ttcgctccgg acgaaccgac tccagcacca cctggcacgc 1800agtcaactgg
gcaagggaac gttcccactg ctcagccaac cggaatgcga caccagctgc
1860gccgcgtaga acggtccttg gcgcttttca ttgcaagctt ggttccgggc
gtgggcgaga 1920gacacgtgga agtgcgcaat gccgcagaag cggcccggaa
cgcagagcgt gcaagagagg 1980aagaagagcg acgtcgacag gaggaagagg
ccaccaacgc aggcacgact ggtgaggctc 2040aggcacaggc acaggagagc
agcgagaacg aacagagaga aacgggtgag aatgcaccca 2100acacgatacc
ccaaactgag aattagccat agcggagcta ttagacttgt actgagtata
2160ctcggtgatt tgaaacttgt gttcatgatg tattgatagc tgcgatcata
tttccatacc 2220gcttagtgcg gcaagatatc ttagtctatt agcgcaacat
atatctactg cagtgtacct 2280tcaagtaatc tatccacatc cacccacaca
taatccactc tatcta 2326471860DNAAspergillus nigerCDS(1)..(1860)
47atg acc gcg tct tca gaa acc cag tcc gct ctg gcg gaa tct cca cag
48Met Thr Ala Ser Ser Glu Thr Gln Ser Ala Leu Ala Glu Ser Pro Gln 1
5 10 15 agc ata gta tta cat gtg cta tgt cca tct tta cct cct cct aac
cga 96Ser Ile Val Leu His Val Leu Cys Pro Ser Leu Pro Pro Pro Asn
Arg 20 25 30 ttc act ctc cac gac atc tct cca tcc acc acc atc tcc
act ctc aaa 144Phe Thr Leu His Asp Ile Ser Pro Ser Thr Thr Ile Ser
Thr Leu Lys 35 40 45 gct cga atc gcc cag acc att ccg agt gaa cca
tcc cct gaa act cag 192Ala Arg Ile Ala Gln Thr Ile Pro Ser Glu Pro
Ser Pro Glu Thr Gln 50 55 60 agg ctg ata tac cgg ggg aag ccc ctt
acg aac gac gcc gtg gcg cta 240Arg Leu Ile Tyr Arg Gly Lys Pro Leu
Thr Asn Asp Ala Val Ala Leu 65 70 75 80 aat gat gtg tta gag tca tca
aat gat acc gag tat tcc atc cac ctc 288Asn Asp Val Leu Glu Ser Ser
Asn Asp Thr Glu Tyr Ser Ile His Leu 85 90 95 gtc ctt cct cct gcc
cca gtt ccc cat gct tca act tct gcc aga gct 336Val Leu Pro Pro Ala
Pro Val Pro His Ala Ser Thr Ser Ala Arg Ala 100 105 110 cct gct cca
atg ccg cgg gga gct tca ggt aac ccc gcg cct cag agt 384Pro Ala Pro
Met Pro Arg Gly Ala Ser Gly Asn Pro Ala Pro Gln Ser 115 120 125 cca
ttc tca tcg aac cga ttc acg ccg caa cac ctg cct cac gga caa 432Pro
Phe Ser Ser Asn Arg Phe Thr Pro Gln His Leu Pro His Gly Gln 130 135
140 gag atc agg tat cga ggt ccc gca ttg ccc gct gtt ccc cat gag gca
480Glu Ile Arg Tyr Arg Gly Pro Ala Leu Pro Ala Val Pro His Glu Ala
145 150 155 160 gag atc gga ctc gcc ttg agg cgg aat atc gag gct att
cgt cga cag 528Glu Ile Gly Leu Ala Leu Arg Arg Asn Ile Glu Ala Ile
Arg Arg Gln 165 170 175 att gat atg cag gaa cgg ggc ggg ccg ttg gga
ggc gtc gcg gca ggc 576Ile Asp Met Gln Glu Arg Gly Gly Pro Leu Gly
Gly Val Ala Ala Gly 180 185 190 acc gcg ggg gct act tcc cac tcg acc
aca tcc acg act acg aca gct 624Thr Ala Gly Ala Thr Ser His Ser Thr
Thr Ser Thr Thr Thr Thr Ala 195 200 205 tcg ttc gct cag caa cct gca
tgg cca cac gta aca cct ggt cta tcg 672Ser Phe Ala Gln Gln Pro Ala
Trp Pro His Val Thr Pro Gly Leu Ser 210 215 220 cac cca gga cat tcg
tcc atc tca tct gat ttc aca atg gct tcc ggc 720His Pro Gly His Ser
Ser Ile Ser Ser Asp Phe Thr Met Ala Ser Gly 225 230 235 240 tca tcg
gga aca gcc aat gtc cat agc aac ctc ccc gaa gaa gtc cga 768Ser Ser
Gly Thr Ala Asn Val His Ser Asn Leu Pro Glu Glu Val Arg 245 250 255
ttg cgc cta caa ata ctc aga aat cag att gcg ttt ggc gaa gag caa
816Leu Arg Leu Gln Ile Leu Arg Asn Gln Ile Ala Phe Gly Glu Glu Gln
260 265 270 ctg aac cgg ggg gtt gcg ccc cca atg gac cat ata att cgc
ata cgt 864Leu Asn Arg Gly Val Ala Pro Pro Met Asp His Ile Ile Arg
Ile Arg 275 280 285 aca caa ttg ttc gct ttg ctc gac gac caa tat cag
aac cca cat gct 912Thr Gln Leu Phe Ala Leu Leu Asp Asp Gln Tyr Gln
Asn Pro His Ala 290 295 300 gag cgc gac ggc tcg att gaa tct ttg ctc
act cgc gtc ttt aat atc 960Glu Arg Asp Gly Ser Ile Glu Ser Leu Leu
Thr Arg Val Phe Asn Ile 305 310 315 320 tat acc cgc gct gat cag ctc
cgc gtc tca caa gct aga acc atg ccc 1008Tyr Thr Arg Ala Asp Gln Leu
Arg Val Ser Gln Ala Arg Thr Met Pro 325 330 335 aca cct gtt cta tct
gga cct ccc aat ccc gca cca ggg cag gct cct 1056Thr Pro Val Leu Ser
Gly Pro Pro Asn Pro Ala Pro Gly Gln Ala Pro 340 345 350 ctg tac ctt
ctc tcg tca cca aac ggc tat caa gcc ctg gtt gca tct 1104Leu Tyr Leu
Leu Ser Ser Pro Asn Gly Tyr Gln Ala Leu Val Ala Ser 355 360 365 ccc
cgc ggt gca gaa acg atg cag tct tct ctc gat aca ctc cga gcc 1152Pro
Arg Gly Ala Glu Thr Met Gln Ser Ser Leu Asp Thr Leu Arg Ala 370
375
380 atg cac tcc ccg acc gga gcc tct gcg cct cgt aca ggt gct cca ccg
1200Met His Ser Pro Thr Gly Ala Ser Ala Pro Arg Thr Gly Ala Pro Pro
385 390 395 400 gag att cac aat gcg aac gca gtt gtc atg gag aac att
gtc cga cag 1248Glu Ile His Asn Ala Asn Ala Val Val Met Glu Asn Ile
Val Arg Gln 405 410 415 gcc gta ctc aac caa cgc atc gaa aac aac ggg
caa ttg agc ttc aca 1296Ala Val Leu Asn Gln Arg Ile Glu Asn Asn Gly
Gln Leu Ser Phe Thr 420 425 430 cgc aat ctc cga cgc atg tgg cta ttt
gtg cgc ttg tat ttc ttc tgc 1344Arg Asn Leu Arg Arg Met Trp Leu Phe
Val Arg Leu Tyr Phe Phe Cys 435 440 445 tac atg ttc agc gaa ccg ggc
aca tgg tct cgc gtg gtg tat gta acc 1392Tyr Met Phe Ser Glu Pro Gly
Thr Trp Ser Arg Val Val Tyr Val Thr 450 455 460 cta gcc gtc ctt gtc
tca ctc ctg tca gaa acc ggg atc cca cag cag 1440Leu Ala Val Leu Val
Ser Leu Leu Ser Glu Thr Gly Ile Pro Gln Gln 465 470 475 480 ttg tac
cga atg ctt gtg gcg cca gtg caa cga cac ctg gaa gga ctg 1488Leu Tyr
Arg Met Leu Val Ala Pro Val Gln Arg His Leu Glu Gly Leu 485 490 495
gtt cat ttc gct ccg gac gaa ccg act cca gca cca cct ggc acg cag
1536Val His Phe Ala Pro Asp Glu Pro Thr Pro Ala Pro Pro Gly Thr Gln
500 505 510 tca act ggg caa ggg aac gtt ccc act gct cag cca acc gga
atg cga 1584Ser Thr Gly Gln Gly Asn Val Pro Thr Ala Gln Pro Thr Gly
Met Arg 515 520 525 cac cag ctg cgc cgc gta gaa cgg tcc ttg gcg ctt
ttc att gca agc 1632His Gln Leu Arg Arg Val Glu Arg Ser Leu Ala Leu
Phe Ile Ala Ser 530 535 540 ttg gtt ccg ggc gtg ggc gag aga cac gtg
gaa gtg cgc aat gcc gca 1680Leu Val Pro Gly Val Gly Glu Arg His Val
Glu Val Arg Asn Ala Ala 545 550 555 560 gaa gcg gcc cgg aac gca gag
cgt gca aga gag gaa gaa gag cga cgt 1728Glu Ala Ala Arg Asn Ala Glu
Arg Ala Arg Glu Glu Glu Glu Arg Arg 565 570 575 cga cag gag gaa gag
gcc acc aac gca ggc acg act ggt gag gct cag 1776Arg Gln Glu Glu Glu
Ala Thr Asn Ala Gly Thr Thr Gly Glu Ala Gln 580 585 590 gca cag gca
cag gag agc agc gag aac gaa cag aga gaa acg ggt gag 1824Ala Gln Ala
Gln Glu Ser Ser Glu Asn Glu Gln Arg Glu Thr Gly Glu 595 600 605 aat
gca ccc aac acg ata ccc caa act gag aat tag 1860Asn Ala Pro Asn Thr
Ile Pro Gln Thr Glu Asn 610 615 48619PRTAspergillus niger 48Met Thr
Ala Ser Ser Glu Thr Gln Ser Ala Leu Ala Glu Ser Pro Gln 1 5 10 15
Ser Ile Val Leu His Val Leu Cys Pro Ser Leu Pro Pro Pro Asn Arg 20
25 30 Phe Thr Leu His Asp Ile Ser Pro Ser Thr Thr Ile Ser Thr Leu
Lys 35 40 45 Ala Arg Ile Ala Gln Thr Ile Pro Ser Glu Pro Ser Pro
Glu Thr Gln 50 55 60 Arg Leu Ile Tyr Arg Gly Lys Pro Leu Thr Asn
Asp Ala Val Ala Leu 65 70 75 80 Asn Asp Val Leu Glu Ser Ser Asn Asp
Thr Glu Tyr Ser Ile His Leu 85 90 95 Val Leu Pro Pro Ala Pro Val
Pro His Ala Ser Thr Ser Ala Arg Ala 100 105 110 Pro Ala Pro Met Pro
Arg Gly Ala Ser Gly Asn Pro Ala Pro Gln Ser 115 120 125 Pro Phe Ser
Ser Asn Arg Phe Thr Pro Gln His Leu Pro His Gly Gln 130 135 140 Glu
Ile Arg Tyr Arg Gly Pro Ala Leu Pro Ala Val Pro His Glu Ala 145 150
155 160 Glu Ile Gly Leu Ala Leu Arg Arg Asn Ile Glu Ala Ile Arg Arg
Gln 165 170 175 Ile Asp Met Gln Glu Arg Gly Gly Pro Leu Gly Gly Val
Ala Ala Gly 180 185 190 Thr Ala Gly Ala Thr Ser His Ser Thr Thr Ser
Thr Thr Thr Thr Ala 195 200 205 Ser Phe Ala Gln Gln Pro Ala Trp Pro
His Val Thr Pro Gly Leu Ser 210 215 220 His Pro Gly His Ser Ser Ile
Ser Ser Asp Phe Thr Met Ala Ser Gly 225 230 235 240 Ser Ser Gly Thr
Ala Asn Val His Ser Asn Leu Pro Glu Glu Val Arg 245 250 255 Leu Arg
Leu Gln Ile Leu Arg Asn Gln Ile Ala Phe Gly Glu Glu Gln 260 265 270
Leu Asn Arg Gly Val Ala Pro Pro Met Asp His Ile Ile Arg Ile Arg 275
280 285 Thr Gln Leu Phe Ala Leu Leu Asp Asp Gln Tyr Gln Asn Pro His
Ala 290 295 300 Glu Arg Asp Gly Ser Ile Glu Ser Leu Leu Thr Arg Val
Phe Asn Ile 305 310 315 320 Tyr Thr Arg Ala Asp Gln Leu Arg Val Ser
Gln Ala Arg Thr Met Pro 325 330 335 Thr Pro Val Leu Ser Gly Pro Pro
Asn Pro Ala Pro Gly Gln Ala Pro 340 345 350 Leu Tyr Leu Leu Ser Ser
Pro Asn Gly Tyr Gln Ala Leu Val Ala Ser 355 360 365 Pro Arg Gly Ala
Glu Thr Met Gln Ser Ser Leu Asp Thr Leu Arg Ala 370 375 380 Met His
Ser Pro Thr Gly Ala Ser Ala Pro Arg Thr Gly Ala Pro Pro 385 390 395
400 Glu Ile His Asn Ala Asn Ala Val Val Met Glu Asn Ile Val Arg Gln
405 410 415 Ala Val Leu Asn Gln Arg Ile Glu Asn Asn Gly Gln Leu Ser
Phe Thr 420 425 430 Arg Asn Leu Arg Arg Met Trp Leu Phe Val Arg Leu
Tyr Phe Phe Cys 435 440 445 Tyr Met Phe Ser Glu Pro Gly Thr Trp Ser
Arg Val Val Tyr Val Thr 450 455 460 Leu Ala Val Leu Val Ser Leu Leu
Ser Glu Thr Gly Ile Pro Gln Gln 465 470 475 480 Leu Tyr Arg Met Leu
Val Ala Pro Val Gln Arg His Leu Glu Gly Leu 485 490 495 Val His Phe
Ala Pro Asp Glu Pro Thr Pro Ala Pro Pro Gly Thr Gln 500 505 510 Ser
Thr Gly Gln Gly Asn Val Pro Thr Ala Gln Pro Thr Gly Met Arg 515 520
525 His Gln Leu Arg Arg Val Glu Arg Ser Leu Ala Leu Phe Ile Ala Ser
530 535 540 Leu Val Pro Gly Val Gly Glu Arg His Val Glu Val Arg Asn
Ala Ala 545 550 555 560 Glu Ala Ala Arg Asn Ala Glu Arg Ala Arg Glu
Glu Glu Glu Arg Arg 565 570 575 Arg Gln Glu Glu Glu Ala Thr Asn Ala
Gly Thr Thr Gly Glu Ala Gln 580 585 590 Ala Gln Ala Gln Glu Ser Ser
Glu Asn Glu Gln Arg Glu Thr Gly Glu 595 600 605 Asn Ala Pro Asn Thr
Ile Pro Gln Thr Glu Asn 610 615 492941DNAAspergillus niger
49tcaggtactc caggtgaact agttggtact actaagcagg aactcccccc ctctctctct
60tcccaaaggt gccttgaaac cctcccggcc atctttggtg cctccatctc atccttttgg
120ctcttgccag ttccccctct tcatctctaa ccttccctac tgggatctat
atttccctac 180ttctctccac tggtctatgt atgcctgagt tcaagatctc
cgcttctttg gagggccacg 240gcgatgatgt aagaacatcc cggctgttga
cgctggccac ctttcacctt caacccccct 300ccattgtcgc ccactgacgc
ctctttctct cactctcagg ttcgcgccgt ggcctttccg 360aatcccaatg
ctatattttc ggcgtcgcga gatgcaacag tccgactctg gaaactagtc
420tctaccccac ctccggcata tgactacacc atcacctctc acggccaggc
cttcatcaac 480gctttggcat actacccacc taccccccag tttcccgatg
gacttgtcct ttccggtggt 540caagatacta tcattgaagc cagacaacca
ggcaaagctg ccgacgataa cgcggatgct 600atgctcttgg gccatacaca
taatgtctgt gcgctggatg tgtcacatga tggcggatgg 660gtagtcagcg
gaagctggga ctcgacagct agactatgga aagtgggtaa atgggaaacc
720gatgtcgtgc tggagggcca tcaaggaagt gtttggacgg tgcttgccta
tgacaaggat 780acggtcatca caggtaggcg cgccttaccc ctgtatatga
gacagatggg tcgttctatg 840gatatgctaa taattcccca ggctgcgcgg
acaaaataat acgtattttt aacacctctg 900gcacactgct gagaacaatc
gaaaattcac aggacgttgt gagagctctt tgcaaggttc 960ccgcttcgaa
ccccaccggg gcgcactttg cttcggcgag caacgatgga gtgattcgtc
1020tttttaccat acaaggccaa ctcgtcgggg agatgcatgg ccacgagagc
ttcatttatt 1080ctctggccgc tttgccttcg ggtgagttag tcagttccgg
agaagatcgg acggtgagag 1140tctgggatgg tacgcagtgc gtacagacga
tcacacaccc tgcgatctct gtctggagcg 1200tcgcagtatg caaggagacc
ggcgacattg ttacaggagc cagtgaccga atcacacgcg 1260tgtttagcag
gagccaggag cgcgtggcaa gcccagaagt agtacaacag ttcgagaaga
1320ctgtgaagga gtcggcaatc ccagagcagc agattgggaa gatcaacaaa
gataagcttc 1380cgggtacgga gtttctcagg cagaaatccg ggaccaagga
cgggcaggtg cagatgatcc 1440gtgaggccga tggtagcgtt actgctcaca
cttggtcagc ggcctcacgg gaatgggttg 1500cggttggcac ggtagttgat
tccgctgcca gcagtggaag gaaaacggag tatctgggtc 1560aagactacga
ctatgtcttt gatgtcgacg tggaagacgg caaacccccc ctcaaattgc
1620catacaacgt ctctcaaaac ccctacgagg ctgcgaccaa gtttatccag
gacaacgaac 1680tgtcgatgaa ttaccttgat caagttgctc agttcatcgt
tcagaatacg caaggtgcga 1740ctcttggtca gacgtctcag gggccgacgc
ccgcgggggc cgatccctgg ggtcaagaga 1800ggcgttatcg tcctgaagat
gcgcagtcgc cccctgctcc tgaggcccga ccgaaggtcc 1860ttccgcaaaa
aacatatctt tccataaaat ctgctaatct taaactgatc gctaagaagt
1920tgcaagagct gaaccaacac gtcatatcct ccggatcgaa agacctgtcg
ctcagccctt 1980cagagttgga gacggtggca accttgtgtg gtcagttgga
gtcttcgaat gttgagcagt 2040ctccggcagt ggaggctggt gttgttttac
tatacaaggt cgcaaccgtc tggcccgtcg 2100caagcagact accaggtctt
gatcttctcc gcttgtccgc cgctgctact cccgtgactg 2160ccactgcaga
ttacgatggc aaggatctca tctcagggat taagtctagc ggggtgttcg
2220attcaccgtt caatgtcaat aatgcgatgc tgtcaatacg catgctcgcc
aaccttttcg 2280aaacggatgc gggacgtgac ctggccacta gcaagtttga
gcagattctg agcggcgtca 2340agtccgcttt aaccaacagt gggacgacgc
cgaaccgaaa tctcaccatt gccattacaa 2400cactctacat caactttgcc
gtttacctga cctctgcggg cagagaatcg atgcctgagt 2460catcggaaca
ggctctggtg cttctcggcg agctaacgac attgattacc ggtgaaaagg
2520actctgaagc agtctaccgc ggccttgtgg ctctagggac cttgatcaag
ggactagggg 2580aagaagtcag gactgcggcc aaggaagtgt acgatgtcga
tgatgttttg aagaaggttt 2640caagctctgg tcttggtaaa gaaccaagaa
tcaagggtat cataggcgag atcaaggagt 2700cgttatcatc aaggtataaa
atgttgaggc ccgggtctta agtcaactca tacctcaagg 2760agcgtcttgt
gttctgcttc accactgctg tctatagcac gtatacatct ctagttcacg
2820atagcgatac acactacact gcatgaattc aacattggac atattccaaa
tcagtgctaa 2880cactaggtat cgtatagtgc tatacattca atgtaacggc
aacgtaaata atcactttga 2940c 2941502331DNAAspergillus
nigerCDS(1)..(2331) 50atg cct gag ttc aag atc tcc gct tct ttg gag
ggc cac ggc gat gat 48Met Pro Glu Phe Lys Ile Ser Ala Ser Leu Glu
Gly His Gly Asp Asp 1 5 10 15 gtt cgc gcc gtg gcc ttt ccg aat ccc
aat gct ata ttt tcg gcg tcg 96Val Arg Ala Val Ala Phe Pro Asn Pro
Asn Ala Ile Phe Ser Ala Ser 20 25 30 cga gat gca aca gtc cga ctc
tgg aaa cta gtc tct acc cca cct ccg 144Arg Asp Ala Thr Val Arg Leu
Trp Lys Leu Val Ser Thr Pro Pro Pro 35 40 45 gca tat gac tac acc
atc acc tct cac ggc cag gcc ttc atc aac gct 192Ala Tyr Asp Tyr Thr
Ile Thr Ser His Gly Gln Ala Phe Ile Asn Ala 50 55 60 ttg gca tac
tac cca cct acc ccc cag ttt ccc gat gga ctt gtc ctt 240Leu Ala Tyr
Tyr Pro Pro Thr Pro Gln Phe Pro Asp Gly Leu Val Leu 65 70 75 80 tcc
ggt ggt caa gat act atc att gaa gcc aga caa cca ggc aaa gct 288Ser
Gly Gly Gln Asp Thr Ile Ile Glu Ala Arg Gln Pro Gly Lys Ala 85 90
95 gcc gac gat aac gcg gat gct atg ctc ttg ggc cat aca cat aat gtc
336Ala Asp Asp Asn Ala Asp Ala Met Leu Leu Gly His Thr His Asn Val
100 105 110 tgt gcg ctg gat gtg tca cat gat ggc gga tgg gta gtc agc
gga agc 384Cys Ala Leu Asp Val Ser His Asp Gly Gly Trp Val Val Ser
Gly Ser 115 120 125 tgg gac tcg aca gct aga cta tgg aaa gtg ggt aaa
tgg gaa acc gat 432Trp Asp Ser Thr Ala Arg Leu Trp Lys Val Gly Lys
Trp Glu Thr Asp 130 135 140 gtc gtg ctg gag ggc cat caa gga agt gtt
tgg acg gtg ctt gcc tat 480Val Val Leu Glu Gly His Gln Gly Ser Val
Trp Thr Val Leu Ala Tyr 145 150 155 160 gac aag gat acg gtc atc aca
ggc tgc gcg gac aaa ata ata cgt att 528Asp Lys Asp Thr Val Ile Thr
Gly Cys Ala Asp Lys Ile Ile Arg Ile 165 170 175 ttt aac acc tct ggc
aca ctg ctg aga aca atc gaa aat tca cag gac 576Phe Asn Thr Ser Gly
Thr Leu Leu Arg Thr Ile Glu Asn Ser Gln Asp 180 185 190 gtt gtg aga
gct ctt tgc aag gtt ccc gct tcg aac ccc acc ggg gcg 624Val Val Arg
Ala Leu Cys Lys Val Pro Ala Ser Asn Pro Thr Gly Ala 195 200 205 cac
ttt gct tcg gcg agc aac gat gga gtg att cgt ctt ttt acc ata 672His
Phe Ala Ser Ala Ser Asn Asp Gly Val Ile Arg Leu Phe Thr Ile 210 215
220 caa ggc caa ctc gtc ggg gag atg cat ggc cac gag agc ttc att tat
720Gln Gly Gln Leu Val Gly Glu Met His Gly His Glu Ser Phe Ile Tyr
225 230 235 240 tct ctg gcc gct ttg cct tcg ggt gag tta gtc agt tcc
gga gaa gat 768Ser Leu Ala Ala Leu Pro Ser Gly Glu Leu Val Ser Ser
Gly Glu Asp 245 250 255 cgg acg gtg aga gtc tgg gat ggt acg cag tgc
gta cag acg atc aca 816Arg Thr Val Arg Val Trp Asp Gly Thr Gln Cys
Val Gln Thr Ile Thr 260 265 270 cac cct gcg atc tct gtc tgg agc gtc
gca gta tgc aag gag acc ggc 864His Pro Ala Ile Ser Val Trp Ser Val
Ala Val Cys Lys Glu Thr Gly 275 280 285 gac att gtt aca gga gcc agt
gac cga atc aca cgc gtg ttt agc agg 912Asp Ile Val Thr Gly Ala Ser
Asp Arg Ile Thr Arg Val Phe Ser Arg 290 295 300 agc cag gag cgc gtg
gca agc cca gaa gta gta caa cag ttc gag aag 960Ser Gln Glu Arg Val
Ala Ser Pro Glu Val Val Gln Gln Phe Glu Lys 305 310 315 320 act gtg
aag gag tcg gca atc cca gag cag cag att ggg aag atc aac 1008Thr Val
Lys Glu Ser Ala Ile Pro Glu Gln Gln Ile Gly Lys Ile Asn 325 330 335
aaa gat aag ctt ccg ggt acg gag ttt ctc agg cag aaa tcc ggg acc
1056Lys Asp Lys Leu Pro Gly Thr Glu Phe Leu Arg Gln Lys Ser Gly Thr
340 345 350 aag gac ggg cag gtg cag atg atc cgt gag gcc gat ggt agc
gtt act 1104Lys Asp Gly Gln Val Gln Met Ile Arg Glu Ala Asp Gly Ser
Val Thr 355 360 365 gct cac act tgg tca gcg gcc tca cgg gaa tgg gtt
gcg gtt ggc acg 1152Ala His Thr Trp Ser Ala Ala Ser Arg Glu Trp Val
Ala Val Gly Thr 370 375 380 gta gtt gat tcc gct gcc agc agt gga agg
aaa acg gag tat ctg ggt 1200Val Val Asp Ser Ala Ala Ser Ser Gly Arg
Lys Thr Glu Tyr Leu Gly 385 390 395 400 caa gac tac gac tat gtc ttt
gat gtc gac gtg gaa gac ggc aaa ccc 1248Gln Asp Tyr Asp Tyr Val Phe
Asp Val Asp Val Glu Asp Gly Lys Pro 405 410 415 ccc ctc aaa ttg cca
tac aac gtc tct caa aac ccc tac gag gct gcg 1296Pro Leu Lys Leu Pro
Tyr Asn Val Ser Gln Asn Pro Tyr Glu Ala Ala 420 425 430 acc aag ttt
atc cag gac aac gaa ctg tcg atg aat tac ctt gat caa 1344Thr Lys Phe
Ile Gln Asp Asn Glu Leu Ser Met Asn Tyr Leu Asp Gln 435 440 445 gtt
gct cag ttc atc gtt cag aat acg caa ggt gcg act ctt gag agg 1392Val
Ala Gln Phe Ile Val Gln Asn Thr Gln Gly Ala Thr Leu Glu Arg 450 455
460 cgt tat cgt cct gaa gat gcg cag tcg ccc cct gct cct gag gcc cga
1440Arg Tyr Arg Pro Glu Asp Ala Gln Ser Pro Pro Ala Pro Glu Ala Arg
465 470 475 480 ccg aag gtc ctt ccg caa aaa aca tat ctt tcc ata aaa
tct gct aat 1488Pro Lys Val Leu Pro Gln Lys Thr Tyr Leu Ser Ile Lys
Ser Ala Asn 485 490 495 ctt aaa ctg atc gct aag aag ttg caa gag ctg
aac caa cac gtc ata 1536Leu Lys Leu Ile Ala Lys Lys Leu Gln Glu Leu
Asn Gln His Val Ile 500 505 510 tcc tcc gga tcg aaa gac ctg tcg ctc
agc cct tca gag ttg gag acg 1584Ser Ser Gly Ser Lys Asp Leu Ser Leu
Ser Pro Ser Glu Leu Glu Thr 515 520 525 gtg
gca acc ttg tgt ggt cag ttg gag tct tcg aat gtt gag cag tct 1632Val
Ala Thr Leu Cys Gly Gln Leu Glu Ser Ser Asn Val Glu Gln Ser 530 535
540 ccg gca gtg gag gct ggt gtt gtt tta cta tac aag gtc gca acc gtc
1680Pro Ala Val Glu Ala Gly Val Val Leu Leu Tyr Lys Val Ala Thr Val
545 550 555 560 tgg ccc gtc gca agc aga cta cca ggt ctt gat ctt ctc
cgc ttg tcc 1728Trp Pro Val Ala Ser Arg Leu Pro Gly Leu Asp Leu Leu
Arg Leu Ser 565 570 575 gcc gct gct act ccc gtg act gcc act gca gat
tac gat ggc aag gat 1776Ala Ala Ala Thr Pro Val Thr Ala Thr Ala Asp
Tyr Asp Gly Lys Asp 580 585 590 ctc atc tca ggg att aag tct agc ggg
gtg ttc gat tca ccg ttc aat 1824Leu Ile Ser Gly Ile Lys Ser Ser Gly
Val Phe Asp Ser Pro Phe Asn 595 600 605 gtc aat aat gcg atg ctg tca
ata cgc atg ctc gcc aac ctt ttc gaa 1872Val Asn Asn Ala Met Leu Ser
Ile Arg Met Leu Ala Asn Leu Phe Glu 610 615 620 acg gat gcg gga cgt
gac ctg gcc act agc aag ttt gag cag att ctg 1920Thr Asp Ala Gly Arg
Asp Leu Ala Thr Ser Lys Phe Glu Gln Ile Leu 625 630 635 640 agc ggc
gtc aag tcc gct tta acc aac agt ggg acg acg ccg aac cga 1968Ser Gly
Val Lys Ser Ala Leu Thr Asn Ser Gly Thr Thr Pro Asn Arg 645 650 655
aat ctc acc att gcc att aca aca ctc tac atc aac ttt gcc gtt tac
2016Asn Leu Thr Ile Ala Ile Thr Thr Leu Tyr Ile Asn Phe Ala Val Tyr
660 665 670 ctg acc tct gcg ggc aga gaa tcg atg cct gag tca tcg gaa
cag gct 2064Leu Thr Ser Ala Gly Arg Glu Ser Met Pro Glu Ser Ser Glu
Gln Ala 675 680 685 ctg gtg ctt ctc ggc gag cta acg aca ttg att acc
ggt gaa aag gac 2112Leu Val Leu Leu Gly Glu Leu Thr Thr Leu Ile Thr
Gly Glu Lys Asp 690 695 700 tct gaa gca gtc tac cgc ggc ctt gtg gct
cta ggg acc ttg atc aag 2160Ser Glu Ala Val Tyr Arg Gly Leu Val Ala
Leu Gly Thr Leu Ile Lys 705 710 715 720 gga cta ggg gaa gaa gtc agg
act gcg gcc aag gaa gtg tac gat gtc 2208Gly Leu Gly Glu Glu Val Arg
Thr Ala Ala Lys Glu Val Tyr Asp Val 725 730 735 gat gat gtt ttg aag
aag gtt tca agc tct ggt ctt ggt aaa gaa cca 2256Asp Asp Val Leu Lys
Lys Val Ser Ser Ser Gly Leu Gly Lys Glu Pro 740 745 750 aga atc aag
ggt atc ata ggc gag atc aag gag tcg tta tca tca agg 2304Arg Ile Lys
Gly Ile Ile Gly Glu Ile Lys Glu Ser Leu Ser Ser Arg 755 760 765 tat
aaa atg ttg agg ccc ggg tct taa 2331Tyr Lys Met Leu Arg Pro Gly Ser
770 775 51776PRTAspergillus niger 51Met Pro Glu Phe Lys Ile Ser Ala
Ser Leu Glu Gly His Gly Asp Asp 1 5 10 15 Val Arg Ala Val Ala Phe
Pro Asn Pro Asn Ala Ile Phe Ser Ala Ser 20 25 30 Arg Asp Ala Thr
Val Arg Leu Trp Lys Leu Val Ser Thr Pro Pro Pro 35 40 45 Ala Tyr
Asp Tyr Thr Ile Thr Ser His Gly Gln Ala Phe Ile Asn Ala 50 55 60
Leu Ala Tyr Tyr Pro Pro Thr Pro Gln Phe Pro Asp Gly Leu Val Leu 65
70 75 80 Ser Gly Gly Gln Asp Thr Ile Ile Glu Ala Arg Gln Pro Gly
Lys Ala 85 90 95 Ala Asp Asp Asn Ala Asp Ala Met Leu Leu Gly His
Thr His Asn Val 100 105 110 Cys Ala Leu Asp Val Ser His Asp Gly Gly
Trp Val Val Ser Gly Ser 115 120 125 Trp Asp Ser Thr Ala Arg Leu Trp
Lys Val Gly Lys Trp Glu Thr Asp 130 135 140 Val Val Leu Glu Gly His
Gln Gly Ser Val Trp Thr Val Leu Ala Tyr 145 150 155 160 Asp Lys Asp
Thr Val Ile Thr Gly Cys Ala Asp Lys Ile Ile Arg Ile 165 170 175 Phe
Asn Thr Ser Gly Thr Leu Leu Arg Thr Ile Glu Asn Ser Gln Asp 180 185
190 Val Val Arg Ala Leu Cys Lys Val Pro Ala Ser Asn Pro Thr Gly Ala
195 200 205 His Phe Ala Ser Ala Ser Asn Asp Gly Val Ile Arg Leu Phe
Thr Ile 210 215 220 Gln Gly Gln Leu Val Gly Glu Met His Gly His Glu
Ser Phe Ile Tyr 225 230 235 240 Ser Leu Ala Ala Leu Pro Ser Gly Glu
Leu Val Ser Ser Gly Glu Asp 245 250 255 Arg Thr Val Arg Val Trp Asp
Gly Thr Gln Cys Val Gln Thr Ile Thr 260 265 270 His Pro Ala Ile Ser
Val Trp Ser Val Ala Val Cys Lys Glu Thr Gly 275 280 285 Asp Ile Val
Thr Gly Ala Ser Asp Arg Ile Thr Arg Val Phe Ser Arg 290 295 300 Ser
Gln Glu Arg Val Ala Ser Pro Glu Val Val Gln Gln Phe Glu Lys 305 310
315 320 Thr Val Lys Glu Ser Ala Ile Pro Glu Gln Gln Ile Gly Lys Ile
Asn 325 330 335 Lys Asp Lys Leu Pro Gly Thr Glu Phe Leu Arg Gln Lys
Ser Gly Thr 340 345 350 Lys Asp Gly Gln Val Gln Met Ile Arg Glu Ala
Asp Gly Ser Val Thr 355 360 365 Ala His Thr Trp Ser Ala Ala Ser Arg
Glu Trp Val Ala Val Gly Thr 370 375 380 Val Val Asp Ser Ala Ala Ser
Ser Gly Arg Lys Thr Glu Tyr Leu Gly 385 390 395 400 Gln Asp Tyr Asp
Tyr Val Phe Asp Val Asp Val Glu Asp Gly Lys Pro 405 410 415 Pro Leu
Lys Leu Pro Tyr Asn Val Ser Gln Asn Pro Tyr Glu Ala Ala 420 425 430
Thr Lys Phe Ile Gln Asp Asn Glu Leu Ser Met Asn Tyr Leu Asp Gln 435
440 445 Val Ala Gln Phe Ile Val Gln Asn Thr Gln Gly Ala Thr Leu Glu
Arg 450 455 460 Arg Tyr Arg Pro Glu Asp Ala Gln Ser Pro Pro Ala Pro
Glu Ala Arg 465 470 475 480 Pro Lys Val Leu Pro Gln Lys Thr Tyr Leu
Ser Ile Lys Ser Ala Asn 485 490 495 Leu Lys Leu Ile Ala Lys Lys Leu
Gln Glu Leu Asn Gln His Val Ile 500 505 510 Ser Ser Gly Ser Lys Asp
Leu Ser Leu Ser Pro Ser Glu Leu Glu Thr 515 520 525 Val Ala Thr Leu
Cys Gly Gln Leu Glu Ser Ser Asn Val Glu Gln Ser 530 535 540 Pro Ala
Val Glu Ala Gly Val Val Leu Leu Tyr Lys Val Ala Thr Val 545 550 555
560 Trp Pro Val Ala Ser Arg Leu Pro Gly Leu Asp Leu Leu Arg Leu Ser
565 570 575 Ala Ala Ala Thr Pro Val Thr Ala Thr Ala Asp Tyr Asp Gly
Lys Asp 580 585 590 Leu Ile Ser Gly Ile Lys Ser Ser Gly Val Phe Asp
Ser Pro Phe Asn 595 600 605 Val Asn Asn Ala Met Leu Ser Ile Arg Met
Leu Ala Asn Leu Phe Glu 610 615 620 Thr Asp Ala Gly Arg Asp Leu Ala
Thr Ser Lys Phe Glu Gln Ile Leu 625 630 635 640 Ser Gly Val Lys Ser
Ala Leu Thr Asn Ser Gly Thr Thr Pro Asn Arg 645 650 655 Asn Leu Thr
Ile Ala Ile Thr Thr Leu Tyr Ile Asn Phe Ala Val Tyr 660 665 670 Leu
Thr Ser Ala Gly Arg Glu Ser Met Pro Glu Ser Ser Glu Gln Ala 675 680
685 Leu Val Leu Leu Gly Glu Leu Thr Thr Leu Ile Thr Gly Glu Lys Asp
690 695 700 Ser Glu Ala Val Tyr Arg Gly Leu Val Ala Leu Gly Thr Leu
Ile Lys 705 710 715 720 Gly Leu Gly Glu Glu Val Arg Thr Ala Ala Lys
Glu Val Tyr Asp Val 725 730 735 Asp Asp Val Leu Lys Lys Val Ser Ser
Ser Gly Leu Gly Lys Glu Pro 740 745 750 Arg Ile Lys Gly Ile Ile Gly
Glu Ile Lys Glu Ser Leu Ser Ser Arg 755 760 765 Tyr Lys Met Leu Arg
Pro Gly Ser 770 775 522505DNAAspergillus niger 52acctaatctc
ttcctttcac ctgatctgct gcctcttccc tccccatccc ctcccctcgt 60cttcccctcc
caaaaagaat ccgccggttt ttccaccttt tccctttctt atccttttcc
120cctcccctcc tcggtggtgt gtatgtctgt aacgggcctt ttatcttcgt
gaacagttta 180attgtgatcc actagaaatc atgggtcaga ccttgtccga
gcccgtggtc gataaggtga 240gtgaaacctg aagcattgcg tttgcctgtc
tggtctttga tcctcctccc ccacactgca 300cgcatcttac gccatttcaa
tctgtccacc atccgcgttg ccattctgtg ccatacccgc 360ccatacttcc
ctttttctat catttgtcca acatgatcac tgcccaaaag ttttatttgc
420tacagcgttc tttttcatcc ctcctcttgt gtgtcgcgcc tgcaatgtgg
tgatcatccc 480ccctgcgggg ttcctccaca ggatgatgaa aatttcctgc
acgcggtttc gggcggatga 540cctgtcacca ttccattgtg ttccggacct
cttttcgatt tcctacatcc tcactaacca 600cattcggtgc tatctagact
tccgctgaag gtcaagatga gtgctgtata tacggtgttt 660ccgccatgca
aggatggcga atcagcatgg aggatgccca tgccgctgtc ctcgacctcc
720aggccaagta ctccgagcag gatgaaaagc cgaccgaccc cgataaacga
ctcgctttct 780ttggtgtata tgacgggcac ggtggagaca aagtagcatt
attcgccgga gaaaacgtcc 840acaagatcgt cgcgaagcag gactcctttg
ccaaaggtga tatcgaacag gccctgaagg 900atggcttcct cgctaccgac
cgggctattt tggaaggttc gtgagcgcta tgatcggagt 960tggggcaacc
ttcccacccg cctctccctt tccttcctgt ttcctgtccc tccgaggtag
1020caacgaactg acccagctag acccgaaata tgaggaggaa gtgtctggct
gcaccgcagc 1080cgtcagcgtt atctcgaagc acaagatctg ggtggtatgt
attctagcca tggccgtttt 1140ggagacgacg ttgggtttgg ttcattcgtt
gactggttct aggccaatgc tggtgattct 1200cgctctgtac tgggtgtcaa
gggtcgcgca aagcctctgt catttgacca caagcctcag 1260aatgaaggta
cacatacccc acatctcgat taccgaccag ttttgatgat gctgacatga
1320ccaaataaaa acaggcgaga aagcccgtat cagcgctgct ggtggtttcg
ttgacttcgg 1380ccgtgtcaac ggcaacctgg ccttgtcgcg ggccattggt
gacttcgagt tcaagaagag 1440ccccgagttg tctcctgagc agcagatcgt
cactgcctat cccgacgtca ctgtgcacga 1500tctcagtgac gatgacgagt
tcctcgtaat tgcctgtgac ggtgggtctt actctggtga 1560tgcgggggtg
agggtcttga agatcgctaa cttttcgaaa ttgcaggtat ctgggattgt
1620cagtcctccc aatcagtggt ggaattcgtc cgccgtggga ttgccgcgaa
gcaggatctg 1680tatcggatct gtgagaacat gatggacaac tgcctggcct
ccaacagtga aaccggcggc 1740gttggctgcg acaatatgac aatggtcatc
atcggtctcc tgaacggtag gaccaaagag 1800gagtggtaca accagatcgc
tgagcgcgtg gcgaacggcg acggcccttg cgctccgccc 1860gagtacggca
agtctctcga ggatcccacg gcctccaatt ccaatcccta ctgactgaac
1920ggggggtgca gctgagttcc gcggccccgg tatccggaat caattcgagg
agaacccgga 1980tgactttgac atggaaaacg accgtgcgcg tggcttcagc
gtccgctcgg gccgcatcat 2040cctcttgggg gacggcactg aattgattcc
ggagcagaac gatgacgaac tctttgatca 2100ggctgaggaa gaccaggacc
ttgtcaatca ggtgcaccgt gattcgcctg atgcggctcg 2160gaatgaacgg
gagggaactc ctgggcctca gtctaaggat acttctcgaa cggacgccgc
2220tgagatatcg gagtcgccgt ctaccaccgc ggagggttcg tccggcagtg
gccctggaac 2280gccgcaaaag cctacgagtt cgtagtcatg atggatctct
tgcatttctc cttaatatgt 2340cttttctttt ttttcctcct tttttcccct
tgccgcgctt gttacctttt tccctttttc 2400ccttttttcc ttattttggt
tctttgaaaa ccacccgtgt gtgattctac gactgtgccc 2460gtttttacct
atttccttac atttacgtgg acttctttct gcctt 2505531275DNAAspergillus
nigerCDS(1)..(1275) 53atg ggt cag acc ttg tcc gag ccc gtg gtc gat
aag act tcc gct gaa 48Met Gly Gln Thr Leu Ser Glu Pro Val Val Asp
Lys Thr Ser Ala Glu 1 5 10 15 ggt caa gat gag tgc tgt ata tac ggt
gtt tcc gcc atg caa gga tgg 96Gly Gln Asp Glu Cys Cys Ile Tyr Gly
Val Ser Ala Met Gln Gly Trp 20 25 30 cga atc agc atg gag gat gcc
cat gcc gct gtc ctc gac ctc cag gcc 144Arg Ile Ser Met Glu Asp Ala
His Ala Ala Val Leu Asp Leu Gln Ala 35 40 45 aag tac tcc gag cag
gat gaa aag ccg acc gac ccc gat aaa cga ctc 192Lys Tyr Ser Glu Gln
Asp Glu Lys Pro Thr Asp Pro Asp Lys Arg Leu 50 55 60 gct ttc ttt
ggt gta tat gac ggg cac ggt gga gac aaa gta gca tta 240Ala Phe Phe
Gly Val Tyr Asp Gly His Gly Gly Asp Lys Val Ala Leu 65 70 75 80 ttc
gcc gga gaa aac gtc cac aag atc gtc gcg aag cag gac tcc ttt 288Phe
Ala Gly Glu Asn Val His Lys Ile Val Ala Lys Gln Asp Ser Phe 85 90
95 gcc aaa ggt gat atc gaa cag gcc ctg aag gat ggc ttc ctc gct acc
336Ala Lys Gly Asp Ile Glu Gln Ala Leu Lys Asp Gly Phe Leu Ala Thr
100 105 110 gac cgg gct att ttg gaa gac ccg aaa tat gag gag gaa gtg
tct ggc 384Asp Arg Ala Ile Leu Glu Asp Pro Lys Tyr Glu Glu Glu Val
Ser Gly 115 120 125 tgc acc gca gcc gtc agc gtt atc tcg aag cac aag
atc tgg gtg gcc 432Cys Thr Ala Ala Val Ser Val Ile Ser Lys His Lys
Ile Trp Val Ala 130 135 140 aat gct ggt gat tct cgc tct gta ctg ggt
gtc aag ggt cgc gca aag 480Asn Ala Gly Asp Ser Arg Ser Val Leu Gly
Val Lys Gly Arg Ala Lys 145 150 155 160 cct ctg tca ttt gac cac aag
cct cag aat gaa ggc gag aaa gcc cgt 528Pro Leu Ser Phe Asp His Lys
Pro Gln Asn Glu Gly Glu Lys Ala Arg 165 170 175 atc agc gct gct ggt
ggt ttc gtt gac ttc ggc cgt gtc aac ggc aac 576Ile Ser Ala Ala Gly
Gly Phe Val Asp Phe Gly Arg Val Asn Gly Asn 180 185 190 ctg gcc ttg
tcg cgg gcc att ggt gac ttc gag ttc aag aag agc ccc 624Leu Ala Leu
Ser Arg Ala Ile Gly Asp Phe Glu Phe Lys Lys Ser Pro 195 200 205 gag
ttg tct cct gag cag cag atc gtc act gcc tat ccc gac gtc act 672Glu
Leu Ser Pro Glu Gln Gln Ile Val Thr Ala Tyr Pro Asp Val Thr 210 215
220 gtg cac gat ctc agt gac gat gac gag ttc ctc gta att gcc tgt gac
720Val His Asp Leu Ser Asp Asp Asp Glu Phe Leu Val Ile Ala Cys Asp
225 230 235 240 ggt atc tgg gat tgt cag tcc tcc caa tca gtg gtg gaa
ttc gtc cgc 768Gly Ile Trp Asp Cys Gln Ser Ser Gln Ser Val Val Glu
Phe Val Arg 245 250 255 cgt ggg att gcc gcg aag cag gat ctg tat cgg
atc tgt gag aac atg 816Arg Gly Ile Ala Ala Lys Gln Asp Leu Tyr Arg
Ile Cys Glu Asn Met 260 265 270 atg gac aac tgc ctg gcc tcc aac agt
gaa acc ggc ggc gtt ggc tgc 864Met Asp Asn Cys Leu Ala Ser Asn Ser
Glu Thr Gly Gly Val Gly Cys 275 280 285 gac aat atg aca atg gtc atc
atc ggt ctc ctg aac gct gag ttc cgc 912Asp Asn Met Thr Met Val Ile
Ile Gly Leu Leu Asn Ala Glu Phe Arg 290 295 300 ggc ccc ggt atc cgg
aat caa ttc gag gag aac ccg gat gac ttt gac 960Gly Pro Gly Ile Arg
Asn Gln Phe Glu Glu Asn Pro Asp Asp Phe Asp 305 310 315 320 atg gaa
aac gac cgt gcg cgt ggc ttc agc gtc cgc tcg ggc cgc atc 1008Met Glu
Asn Asp Arg Ala Arg Gly Phe Ser Val Arg Ser Gly Arg Ile 325 330 335
atc ctc ttg ggg gac ggc act gaa ttg att ccg gag cag aac gat gac
1056Ile Leu Leu Gly Asp Gly Thr Glu Leu Ile Pro Glu Gln Asn Asp Asp
340 345 350 gaa ctc ttt gat cag gct gag gaa gac cag gac ctt gtc aat
cag gtg 1104Glu Leu Phe Asp Gln Ala Glu Glu Asp Gln Asp Leu Val Asn
Gln Val 355 360 365 cac cgt gat tcg cct gat gcg gct cgg aat gaa cgg
gag gga act cct 1152His Arg Asp Ser Pro Asp Ala Ala Arg Asn Glu Arg
Glu Gly Thr Pro 370 375 380 ggg cct cag tct aag gat act tct cga acg
gac gcc gct gag ata tcg 1200Gly Pro Gln Ser Lys Asp Thr Ser Arg Thr
Asp Ala Ala Glu Ile Ser 385 390 395 400 gag tcg ccg tct acc acc gcg
gag ggt tcg tcc ggc agt ggc cct gga 1248Glu Ser Pro Ser Thr Thr Ala
Glu Gly Ser Ser Gly Ser Gly Pro Gly 405 410 415 acg ccg caa aag cct
acg agt tcg tag 1275Thr Pro Gln Lys Pro Thr Ser Ser 420
54424PRTAspergillus niger 54Met Gly Gln Thr Leu Ser Glu Pro Val Val
Asp Lys Thr Ser Ala Glu 1 5 10 15 Gly Gln Asp Glu Cys Cys Ile Tyr
Gly Val Ser Ala Met Gln Gly Trp 20 25 30 Arg Ile Ser Met Glu Asp
Ala His Ala Ala Val Leu Asp Leu Gln Ala 35 40 45 Lys Tyr Ser Glu
Gln Asp Glu Lys Pro Thr Asp Pro Asp Lys Arg Leu 50
55 60 Ala Phe Phe Gly Val Tyr Asp Gly His Gly Gly Asp Lys Val Ala
Leu 65 70 75 80 Phe Ala Gly Glu Asn Val His Lys Ile Val Ala Lys Gln
Asp Ser Phe 85 90 95 Ala Lys Gly Asp Ile Glu Gln Ala Leu Lys Asp
Gly Phe Leu Ala Thr 100 105 110 Asp Arg Ala Ile Leu Glu Asp Pro Lys
Tyr Glu Glu Glu Val Ser Gly 115 120 125 Cys Thr Ala Ala Val Ser Val
Ile Ser Lys His Lys Ile Trp Val Ala 130 135 140 Asn Ala Gly Asp Ser
Arg Ser Val Leu Gly Val Lys Gly Arg Ala Lys 145 150 155 160 Pro Leu
Ser Phe Asp His Lys Pro Gln Asn Glu Gly Glu Lys Ala Arg 165 170 175
Ile Ser Ala Ala Gly Gly Phe Val Asp Phe Gly Arg Val Asn Gly Asn 180
185 190 Leu Ala Leu Ser Arg Ala Ile Gly Asp Phe Glu Phe Lys Lys Ser
Pro 195 200 205 Glu Leu Ser Pro Glu Gln Gln Ile Val Thr Ala Tyr Pro
Asp Val Thr 210 215 220 Val His Asp Leu Ser Asp Asp Asp Glu Phe Leu
Val Ile Ala Cys Asp 225 230 235 240 Gly Ile Trp Asp Cys Gln Ser Ser
Gln Ser Val Val Glu Phe Val Arg 245 250 255 Arg Gly Ile Ala Ala Lys
Gln Asp Leu Tyr Arg Ile Cys Glu Asn Met 260 265 270 Met Asp Asn Cys
Leu Ala Ser Asn Ser Glu Thr Gly Gly Val Gly Cys 275 280 285 Asp Asn
Met Thr Met Val Ile Ile Gly Leu Leu Asn Ala Glu Phe Arg 290 295 300
Gly Pro Gly Ile Arg Asn Gln Phe Glu Glu Asn Pro Asp Asp Phe Asp 305
310 315 320 Met Glu Asn Asp Arg Ala Arg Gly Phe Ser Val Arg Ser Gly
Arg Ile 325 330 335 Ile Leu Leu Gly Asp Gly Thr Glu Leu Ile Pro Glu
Gln Asn Asp Asp 340 345 350 Glu Leu Phe Asp Gln Ala Glu Glu Asp Gln
Asp Leu Val Asn Gln Val 355 360 365 His Arg Asp Ser Pro Asp Ala Ala
Arg Asn Glu Arg Glu Gly Thr Pro 370 375 380 Gly Pro Gln Ser Lys Asp
Thr Ser Arg Thr Asp Ala Ala Glu Ile Ser 385 390 395 400 Glu Ser Pro
Ser Thr Thr Ala Glu Gly Ser Ser Gly Ser Gly Pro Gly 405 410 415 Thr
Pro Gln Lys Pro Thr Ser Ser 420 551209DNAAspergillus niger
55ctggcagtta tttagtggtg attcggcatc atccccttat cgatcatact cgcccgtctt
60ctctcgagtc cttaaacgcc aaaagacgac tgtctgcatc ctctctattt cgcttaccgc
120ttcgtcgcat cgtacccgcc acccgagcaa cctcccccct aagttaatcc
caacgttcgc 180aactctacta cccatcaatt atggccgcca tctggggtaa
cggcgggcag gctggccagt 240tcccgctgga gcaatggttc tatgaaatgc
cccctgtaac tcgatggtgg acagcagcca 300cagttgccac ttcagtcttg
gtccaatgtc acgtcctcac cccattccag ctgttttata 360gcttccgcgc
agtctatgtt aagtctcagg tacgtcgcag ctagtacttc cgtccactgt
420atagggtaga cgaatcacgc ggctaaccat cgcatagtat tggcgtctgt
tcacaacctt 480cctatacttc ggaccactca atctcgactt actatttcat
gtgttcttct tgcagcgata 540ctcgcgcctc ttggaggaat catcggggcg
atcgccggcc cacttctcgt ggcttctgtt 600ctacgccatg gcctctctcc
tcgtcctctc gccatttctc tcccttccat tcctgggcac 660ggctctctct
tccagtctgg tctacatctg gagtcgtcgc aacccggaaa ctcgcctcag
720cttcctagga atgctggtct tcaccgcccc ctatctcccc tgggttctga
tggcattcag 780cctggtcgtc catggcatcg tgcccaagga tgaaatctgc
ggcgttgtcg tcggccacgt 840ctggtacttc ttcaacgatg tttacccttc
gcttcacggt ggtcaccgtc ctttcgatcc 900tcctatgtgg tgggtgcgtc
tgtttgagtc agggcccggg gaacgaggca ccgacgctgc 960caacgtcaac
ggggaattcg ccgctgctgc tgcacccgaa gttcggtgag ctatttgtgc
1020accccactgg ggcatttact gcatggcgat gcaaagaatc gtccgcgtaa
tcgctctgga 1080aacgtcagca tatatgtgtg tactgccaac tactcgcgcc
gacacgcgcg aagcatgaga 1140agttaatact gtcaggatat aagcaaggat
cacggcggca gacttgatgg gatttcttat 1200cgtgtggct
120956741DNAAspergillus nigerCDS(1)..(741) 56atg gcc gcc atc tgg
ggt aac ggc ggg cag gct ggc cag ttc ccg ctg 48Met Ala Ala Ile Trp
Gly Asn Gly Gly Gln Ala Gly Gln Phe Pro Leu 1 5 10 15 gag caa tgg
ttc tat gaa atg ccc cct gta act cga tgg tgg aca gca 96Glu Gln Trp
Phe Tyr Glu Met Pro Pro Val Thr Arg Trp Trp Thr Ala 20 25 30 gcc
aca gtt gcc act tca gtc ttg gtc caa tgt cac gtc ctc acc cca 144Ala
Thr Val Ala Thr Ser Val Leu Val Gln Cys His Val Leu Thr Pro 35 40
45 ttc cag ctg ttt tat agc ttc cgc gca gtc tat gtt aag tct cag tat
192Phe Gln Leu Phe Tyr Ser Phe Arg Ala Val Tyr Val Lys Ser Gln Tyr
50 55 60 tgg cgt ctg ttc aca acc ttc cta tac ttc gga cca ctc aat
ctc gac 240Trp Arg Leu Phe Thr Thr Phe Leu Tyr Phe Gly Pro Leu Asn
Leu Asp 65 70 75 80 tta cta ttt cat gtg ttc ttc ttg cag cga tac tcg
cgc ctc ttg gag 288Leu Leu Phe His Val Phe Phe Leu Gln Arg Tyr Ser
Arg Leu Leu Glu 85 90 95 gaa tca tcg ggg cga tcg ccg gcc cac ttc
tcg tgg ctt ctg ttc tac 336Glu Ser Ser Gly Arg Ser Pro Ala His Phe
Ser Trp Leu Leu Phe Tyr 100 105 110 gcc atg gcc tct ctc ctc gtc ctc
tcg cca ttt ctc tcc ctt cca ttc 384Ala Met Ala Ser Leu Leu Val Leu
Ser Pro Phe Leu Ser Leu Pro Phe 115 120 125 ctg ggc acg gct ctc tct
tcc agt ctg gtc tac atc tgg agt cgt cgc 432Leu Gly Thr Ala Leu Ser
Ser Ser Leu Val Tyr Ile Trp Ser Arg Arg 130 135 140 aac ccg gaa act
cgc ctc agc ttc cta gga atg ctg gtc ttc acc gcc 480Asn Pro Glu Thr
Arg Leu Ser Phe Leu Gly Met Leu Val Phe Thr Ala 145 150 155 160 ccc
tat ctc ccc tgg gtt ctg atg gca ttc agc ctg gtc gtc cat ggc 528Pro
Tyr Leu Pro Trp Val Leu Met Ala Phe Ser Leu Val Val His Gly 165 170
175 atc gtg ccc aag gat gaa atc tgc ggc gtt gtc gtc ggc cac gtc tgg
576Ile Val Pro Lys Asp Glu Ile Cys Gly Val Val Val Gly His Val Trp
180 185 190 tac ttc ttc aac gat gtt tac cct tcg ctt cac ggt ggt cac
cgt cct 624Tyr Phe Phe Asn Asp Val Tyr Pro Ser Leu His Gly Gly His
Arg Pro 195 200 205 ttc gat cct cct atg tgg tgg gtg cgt ctg ttt gag
tca ggg ccc ggg 672Phe Asp Pro Pro Met Trp Trp Val Arg Leu Phe Glu
Ser Gly Pro Gly 210 215 220 gaa cga ggc acc gac gct gcc aac gtc aac
ggg gaa ttc gcc gct gct 720Glu Arg Gly Thr Asp Ala Ala Asn Val Asn
Gly Glu Phe Ala Ala Ala 225 230 235 240 gct gca ccc gaa gtt cgg tga
741Ala Ala Pro Glu Val Arg 245 57246PRTAspergillus niger 57Met Ala
Ala Ile Trp Gly Asn Gly Gly Gln Ala Gly Gln Phe Pro Leu 1 5 10 15
Glu Gln Trp Phe Tyr Glu Met Pro Pro Val Thr Arg Trp Trp Thr Ala 20
25 30 Ala Thr Val Ala Thr Ser Val Leu Val Gln Cys His Val Leu Thr
Pro 35 40 45 Phe Gln Leu Phe Tyr Ser Phe Arg Ala Val Tyr Val Lys
Ser Gln Tyr 50 55 60 Trp Arg Leu Phe Thr Thr Phe Leu Tyr Phe Gly
Pro Leu Asn Leu Asp 65 70 75 80 Leu Leu Phe His Val Phe Phe Leu Gln
Arg Tyr Ser Arg Leu Leu Glu 85 90 95 Glu Ser Ser Gly Arg Ser Pro
Ala His Phe Ser Trp Leu Leu Phe Tyr 100 105 110 Ala Met Ala Ser Leu
Leu Val Leu Ser Pro Phe Leu Ser Leu Pro Phe 115 120 125 Leu Gly Thr
Ala Leu Ser Ser Ser Leu Val Tyr Ile Trp Ser Arg Arg 130 135 140 Asn
Pro Glu Thr Arg Leu Ser Phe Leu Gly Met Leu Val Phe Thr Ala 145 150
155 160 Pro Tyr Leu Pro Trp Val Leu Met Ala Phe Ser Leu Val Val His
Gly 165 170 175 Ile Val Pro Lys Asp Glu Ile Cys Gly Val Val Val Gly
His Val Trp 180 185 190 Tyr Phe Phe Asn Asp Val Tyr Pro Ser Leu His
Gly Gly His Arg Pro 195 200 205 Phe Asp Pro Pro Met Trp Trp Val Arg
Leu Phe Glu Ser Gly Pro Gly 210 215 220 Glu Arg Gly Thr Asp Ala Ala
Asn Val Asn Gly Glu Phe Ala Ala Ala 225 230 235 240 Ala Ala Pro Glu
Val Arg 245 582538DNAAspergillus niger 58gaagcttggc ggtggtggtc
atgtctttcc aggcccctcg gaacagttct ccattttcgt 60ctcagcaacc gttccagaat
aactactggc gtgctagtcg aagccctggg accaacgggc 120tgcctggcta
tgggttttcg ccaccgactg gtatctccaa ctccctgaac aatcccctcg
180ccggcgaccg cactctcccc atgtacaagg acaaacctta cttcgcacca
cgacgcaccg 240gtccgagagc caggcggcgg aagatcatat atagtgggct
atgtctgttc gtcctgctcg 300ctctgtggta ctactctggc tctggtaagc
cggaatggaa gacaccggac gcggagaagg 360gcgccgagct ctggaagtgg
gtgcaaagtt ttgaggagtc ggaaccacca tacgatggca 420gcgcagcgac
agagaagatt gactgggaag caaggaggga gaaagtgcgc gacgtcttca
480ttgtcagttg ggatggttat gcggctaatg cgtggggtga gtttctggct
ggaattaacc 540tcttgattct tggatgtggt gactgacaat ggctttgtct
gccggtgatt aggttacgat 600gaataccacc caattgccaa aaacggtcgg
cacatgattg aaggaggaat ggggtggata 660attgttgatg cgctggacac
tttgatgatt atgaacctga cgtcgcgagt gcaacatgcc 720cgcagctgga
tccacaactc gttgcaatac aaccaggacc acgatgtgaa taccttcgag
780actaccattc gcatgctggg aggcttactc tccgcacact atctctccac
gaactatccc 840gagctagctc cgcttacgga tgacgataca ggcgcgccgg
gagaagactt gtatatcgag 900aaggccaccg atctggcaga tcgtctattg
ggtgcttttg aatccggcac tggaatcccg 960tatgcaagca tcaatttgaa
caaatccgag ggccttccct cgtacgcgga taatggcgcc 1020tcatctactg
ccgaagccac tactctccag ctggagttca agtacttggc caaactgacg
1080ggcgaggccg agtactggca ggctgtggag aaggttatgg aggtcgtgga
cgaccagaag 1140atggaagacg gattgcttcc gatctacgta tatccagaga
ccggcgaatt taaaggcgat 1200aacatccgtc tcggcagtag aggcgattca
tactatggta tacatgatgg ctttgtgcgt 1260gaatattcaa tgcgctgacc
gatgtttcct agaatacctc atcaagcagt accttcaaac 1320gcaagagact
gaaccgatct acaaggacat gtgggatgag tccctcgtcg gcgtgcgcaa
1380gcacctgatc acctatacac agaacgccaa gttgaccgtt ctgggcgaac
gccctgccgg 1440gctgcatgga gtcctttccc ccaagatgga ccacctagtc
tgcttctacc ccggcaccat 1500cgctctcgca gcaactggcg gacgtcctct
gtccgaggca agacagtcac ccgattgggg 1560ccaacgccag gaggaagaga
ttcttctagc ccgagaacta accaagacct gctgggcaac 1620gtatctaatc
acgaagaccg gcctcgcacc agagatcacc tacttcaatg tcgacgaccc
1680tcgcgtcatg gaaacagaca tgtacccaga ctcgaccatt gccaaaccca
gctcaggcca 1740gcaaaaagcc tctggcgaac tccccctcct ctccaaatcc
atctaccccg tcagcgacta 1800ctccaccaaa tggcgcgacg acctcaacat
ccacaaacaa gaccgccaca acctccaacg 1860cccagagacc gtcgaatccc
tcttctacat gtatcgcatc accggagacg acatctaccg 1920acactggggc
tgggagatgt tcaagtcttt tgtcaagcat actgccgtgg tcgaggacat
1980ccctgtcgat gaactcagca aagaagacgc gtccagctca acatcatcat
cggaggaaga 2040agacggcgga actcagaagc caaaacctca gaaaatcacg
ggcttcacct cgctctcaaa 2100cgctgatgac aaccctccag tgaagcgcga
caacatggag agtttctgga tggccgagac 2160gcttaaatac ttctacttgc
tattctcgga ccgcgacttt atctctctcg aagaccatgt 2220attcaatacg
gaggcgcatc ctctcccgcg gttcaagcca acgggcgagt tgaagaccgg
2280gtggatgagg aagagtcgga cgataccaac atccagtgag gtggaggagt
cggtataatt 2340tctttgacta tctatttttt ttcttatgct tttatatatc
tctctcttgg actacgtctc 2400cttagatccc tctaacaaaa aagaaagata
tctcgaattg attgatcatc tcttgatttt 2460gtttgtttga tgcttgctta
tatgtactgc tatatattgc tcctgcattc tggctggtta 2520catccaaggc agggactt
2538591812DNAAspergillus nigerCDS(1)..(1812) 59atg tac aag gac aaa
cct tac ttc gca cca cga cgc acc ggt ccg aga 48Met Tyr Lys Asp Lys
Pro Tyr Phe Ala Pro Arg Arg Thr Gly Pro Arg 1 5 10 15 gcc agg cgg
cgg aag atc ata tat agt ggg cta tgt ctg ttc gtc ctg 96Ala Arg Arg
Arg Lys Ile Ile Tyr Ser Gly Leu Cys Leu Phe Val Leu 20 25 30 ctc
gct ctg tgg tac tac tct ggc tct ggt aag ccg gaa tgg aag aca 144Leu
Ala Leu Trp Tyr Tyr Ser Gly Ser Gly Lys Pro Glu Trp Lys Thr 35 40
45 ccg gac gcg gag aag ggc gcc gag ctc tgg aag tgg gtg caa agt ttt
192Pro Asp Ala Glu Lys Gly Ala Glu Leu Trp Lys Trp Val Gln Ser Phe
50 55 60 gag gag tcg gaa cca cca tac gat ggc agc gca gcg aca gag
aag att 240Glu Glu Ser Glu Pro Pro Tyr Asp Gly Ser Ala Ala Thr Glu
Lys Ile 65 70 75 80 gac tgg gaa gca agg agg gag aaa gtg cgc gac gtc
ttc att gtc agt 288Asp Trp Glu Ala Arg Arg Glu Lys Val Arg Asp Val
Phe Ile Val Ser 85 90 95 tgg gat ggt tat gcg gct aat gcg tgg ggt
tac gat gaa tac cac cca 336Trp Asp Gly Tyr Ala Ala Asn Ala Trp Gly
Tyr Asp Glu Tyr His Pro 100 105 110 att gcc aaa aac ggt cgg cac atg
att gaa gga gga atg ggg tgg ata 384Ile Ala Lys Asn Gly Arg His Met
Ile Glu Gly Gly Met Gly Trp Ile 115 120 125 att gtt gat gcg ctg gac
act ttg atg att atg aac ctg acg tcg cga 432Ile Val Asp Ala Leu Asp
Thr Leu Met Ile Met Asn Leu Thr Ser Arg 130 135 140 gtg caa cat gcc
cgc agc tgg atc cac aac tcg ttg caa tac aac cag 480Val Gln His Ala
Arg Ser Trp Ile His Asn Ser Leu Gln Tyr Asn Gln 145 150 155 160 gac
cac gat gtg aat acc ttc gag act acc att cgc atg ctg gga ggc 528Asp
His Asp Val Asn Thr Phe Glu Thr Thr Ile Arg Met Leu Gly Gly 165 170
175 tta ctc tcc gca cac tat ctc tcc acg aac tat ccc gag cta gct ccg
576Leu Leu Ser Ala His Tyr Leu Ser Thr Asn Tyr Pro Glu Leu Ala Pro
180 185 190 ctt acg gat gac gat aca ggc gcg ccg gga gaa gac ttg tat
atc gag 624Leu Thr Asp Asp Asp Thr Gly Ala Pro Gly Glu Asp Leu Tyr
Ile Glu 195 200 205 aag gcc acc gat ctg gca gat cgt cta ttg ggt gct
ttt gaa tcc ggc 672Lys Ala Thr Asp Leu Ala Asp Arg Leu Leu Gly Ala
Phe Glu Ser Gly 210 215 220 act gga atc ccg tat gca agc atc aat ttg
aac aaa tcc gag ggc ctt 720Thr Gly Ile Pro Tyr Ala Ser Ile Asn Leu
Asn Lys Ser Glu Gly Leu 225 230 235 240 ccc tcg tac gcg gat aat ggc
gcc tca tct act gcc gaa gcc act act 768Pro Ser Tyr Ala Asp Asn Gly
Ala Ser Ser Thr Ala Glu Ala Thr Thr 245 250 255 ctc cag ctg gag ttc
aag tac ttg gcc aaa ctg acg ggc gag gcc gag 816Leu Gln Leu Glu Phe
Lys Tyr Leu Ala Lys Leu Thr Gly Glu Ala Glu 260 265 270 tac tgg cag
gct gtg gag aag gtt atg gag gtc gtg gac gac cag aag 864Tyr Trp Gln
Ala Val Glu Lys Val Met Glu Val Val Asp Asp Gln Lys 275 280 285 atg
gaa gac gga ttg ctt ccg atc tac gta tat cca gag acc ggc gaa 912Met
Glu Asp Gly Leu Leu Pro Ile Tyr Val Tyr Pro Glu Thr Gly Glu 290 295
300 ttt aaa ggc gat aac atc cgt ctc ggc agt aga ggc gat tca tac tat
960Phe Lys Gly Asp Asn Ile Arg Leu Gly Ser Arg Gly Asp Ser Tyr Tyr
305 310 315 320 gaa tac ctc atc aag cag tac ctt caa acg caa gag act
gaa ccg atc 1008Glu Tyr Leu Ile Lys Gln Tyr Leu Gln Thr Gln Glu Thr
Glu Pro Ile 325 330 335 tac aag gac atg tgg gat gag tcc ctc gtc ggc
gtg cgc aag cac ctg 1056Tyr Lys Asp Met Trp Asp Glu Ser Leu Val Gly
Val Arg Lys His Leu 340 345 350 atc acc tat aca cag aac gcc aag ttg
acc gtt ctg ggc gaa cgc cct 1104Ile Thr Tyr Thr Gln Asn Ala Lys Leu
Thr Val Leu Gly Glu Arg Pro 355 360 365 gcc ggg ctg cat gga gtc ctt
tcc ccc aag atg gac cac cta gtc tgc 1152Ala Gly Leu His Gly Val Leu
Ser Pro Lys Met Asp His Leu Val Cys 370 375 380 ttc tac ccc ggc acc
atc gct ctc gca gca act ggc gga cgt cct ctg 1200Phe Tyr Pro Gly Thr
Ile Ala Leu Ala Ala Thr Gly Gly Arg Pro Leu 385 390 395 400 tcc gag
gca aga cag tca ccc gat tgg ggc caa cgc cag gag gaa gag 1248Ser Glu
Ala Arg Gln Ser Pro Asp Trp Gly Gln Arg Gln Glu Glu Glu 405 410 415
att ctt cta gcc cga gaa cta acc aag acc tgc tgg gca acg tat cta
1296Ile Leu Leu Ala Arg Glu Leu Thr Lys Thr Cys Trp Ala Thr Tyr Leu
420 425 430 atc acg aag acc ggc ctc gca cca gag
atc acc tac ttc aat gtc gac 1344Ile Thr Lys Thr Gly Leu Ala Pro Glu
Ile Thr Tyr Phe Asn Val Asp 435 440 445 gac cct cgc gtc atg gaa aca
gac atc gac tac tcc acc aaa tgg cgc 1392Asp Pro Arg Val Met Glu Thr
Asp Ile Asp Tyr Ser Thr Lys Trp Arg 450 455 460 gac gac ctc aac atc
cac aaa caa gac cgc cac aac ctc caa cgc cca 1440Asp Asp Leu Asn Ile
His Lys Gln Asp Arg His Asn Leu Gln Arg Pro 465 470 475 480 gag acc
gtc gaa tcc ctc ttc tac atg tat cgc atc acc gga gac gac 1488Glu Thr
Val Glu Ser Leu Phe Tyr Met Tyr Arg Ile Thr Gly Asp Asp 485 490 495
atc tac cga cac tgg ggc tgg gag atg ttc aag tct ttt gtc aag cat
1536Ile Tyr Arg His Trp Gly Trp Glu Met Phe Lys Ser Phe Val Lys His
500 505 510 act gcc gtg aaa atc acg ggc ttc acc tcg ctc tca aac gct
gat gac 1584Thr Ala Val Lys Ile Thr Gly Phe Thr Ser Leu Ser Asn Ala
Asp Asp 515 520 525 aac cct cca gtg aag cgc gac aac atg gag agt ttc
tgg atg gcc gag 1632Asn Pro Pro Val Lys Arg Asp Asn Met Glu Ser Phe
Trp Met Ala Glu 530 535 540 acg ctt aaa tac ttc tac ttg cta ttc tcg
gac cgc gac ttt atc tct 1680Thr Leu Lys Tyr Phe Tyr Leu Leu Phe Ser
Asp Arg Asp Phe Ile Ser 545 550 555 560 ctc gaa gac cat gta ttc aat
acg gag gcg cat cct ctc ccg cgg ttc 1728Leu Glu Asp His Val Phe Asn
Thr Glu Ala His Pro Leu Pro Arg Phe 565 570 575 aag cca acg ggc gag
ttg aag acc ggg tgg atg agg aag agt cgg acg 1776Lys Pro Thr Gly Glu
Leu Lys Thr Gly Trp Met Arg Lys Ser Arg Thr 580 585 590 ata cca aca
tcc agt gag gtg gag gag tcg gta taa 1812Ile Pro Thr Ser Ser Glu Val
Glu Glu Ser Val 595 600 60603PRTAspergillus niger 60Met Tyr Lys Asp
Lys Pro Tyr Phe Ala Pro Arg Arg Thr Gly Pro Arg 1 5 10 15 Ala Arg
Arg Arg Lys Ile Ile Tyr Ser Gly Leu Cys Leu Phe Val Leu 20 25 30
Leu Ala Leu Trp Tyr Tyr Ser Gly Ser Gly Lys Pro Glu Trp Lys Thr 35
40 45 Pro Asp Ala Glu Lys Gly Ala Glu Leu Trp Lys Trp Val Gln Ser
Phe 50 55 60 Glu Glu Ser Glu Pro Pro Tyr Asp Gly Ser Ala Ala Thr
Glu Lys Ile 65 70 75 80 Asp Trp Glu Ala Arg Arg Glu Lys Val Arg Asp
Val Phe Ile Val Ser 85 90 95 Trp Asp Gly Tyr Ala Ala Asn Ala Trp
Gly Tyr Asp Glu Tyr His Pro 100 105 110 Ile Ala Lys Asn Gly Arg His
Met Ile Glu Gly Gly Met Gly Trp Ile 115 120 125 Ile Val Asp Ala Leu
Asp Thr Leu Met Ile Met Asn Leu Thr Ser Arg 130 135 140 Val Gln His
Ala Arg Ser Trp Ile His Asn Ser Leu Gln Tyr Asn Gln 145 150 155 160
Asp His Asp Val Asn Thr Phe Glu Thr Thr Ile Arg Met Leu Gly Gly 165
170 175 Leu Leu Ser Ala His Tyr Leu Ser Thr Asn Tyr Pro Glu Leu Ala
Pro 180 185 190 Leu Thr Asp Asp Asp Thr Gly Ala Pro Gly Glu Asp Leu
Tyr Ile Glu 195 200 205 Lys Ala Thr Asp Leu Ala Asp Arg Leu Leu Gly
Ala Phe Glu Ser Gly 210 215 220 Thr Gly Ile Pro Tyr Ala Ser Ile Asn
Leu Asn Lys Ser Glu Gly Leu 225 230 235 240 Pro Ser Tyr Ala Asp Asn
Gly Ala Ser Ser Thr Ala Glu Ala Thr Thr 245 250 255 Leu Gln Leu Glu
Phe Lys Tyr Leu Ala Lys Leu Thr Gly Glu Ala Glu 260 265 270 Tyr Trp
Gln Ala Val Glu Lys Val Met Glu Val Val Asp Asp Gln Lys 275 280 285
Met Glu Asp Gly Leu Leu Pro Ile Tyr Val Tyr Pro Glu Thr Gly Glu 290
295 300 Phe Lys Gly Asp Asn Ile Arg Leu Gly Ser Arg Gly Asp Ser Tyr
Tyr 305 310 315 320 Glu Tyr Leu Ile Lys Gln Tyr Leu Gln Thr Gln Glu
Thr Glu Pro Ile 325 330 335 Tyr Lys Asp Met Trp Asp Glu Ser Leu Val
Gly Val Arg Lys His Leu 340 345 350 Ile Thr Tyr Thr Gln Asn Ala Lys
Leu Thr Val Leu Gly Glu Arg Pro 355 360 365 Ala Gly Leu His Gly Val
Leu Ser Pro Lys Met Asp His Leu Val Cys 370 375 380 Phe Tyr Pro Gly
Thr Ile Ala Leu Ala Ala Thr Gly Gly Arg Pro Leu 385 390 395 400 Ser
Glu Ala Arg Gln Ser Pro Asp Trp Gly Gln Arg Gln Glu Glu Glu 405 410
415 Ile Leu Leu Ala Arg Glu Leu Thr Lys Thr Cys Trp Ala Thr Tyr Leu
420 425 430 Ile Thr Lys Thr Gly Leu Ala Pro Glu Ile Thr Tyr Phe Asn
Val Asp 435 440 445 Asp Pro Arg Val Met Glu Thr Asp Ile Asp Tyr Ser
Thr Lys Trp Arg 450 455 460 Asp Asp Leu Asn Ile His Lys Gln Asp Arg
His Asn Leu Gln Arg Pro 465 470 475 480 Glu Thr Val Glu Ser Leu Phe
Tyr Met Tyr Arg Ile Thr Gly Asp Asp 485 490 495 Ile Tyr Arg His Trp
Gly Trp Glu Met Phe Lys Ser Phe Val Lys His 500 505 510 Thr Ala Val
Lys Ile Thr Gly Phe Thr Ser Leu Ser Asn Ala Asp Asp 515 520 525 Asn
Pro Pro Val Lys Arg Asp Asn Met Glu Ser Phe Trp Met Ala Glu 530 535
540 Thr Leu Lys Tyr Phe Tyr Leu Leu Phe Ser Asp Arg Asp Phe Ile Ser
545 550 555 560 Leu Glu Asp His Val Phe Asn Thr Glu Ala His Pro Leu
Pro Arg Phe 565 570 575 Lys Pro Thr Gly Glu Leu Lys Thr Gly Trp Met
Arg Lys Ser Arg Thr 580 585 590 Ile Pro Thr Ser Ser Glu Val Glu Glu
Ser Val 595 600 612113DNAAspergillus niger 61cccgcaatcc ccgtcgacct
catcgcttcc tccctttctc ctccatcctc tctctcttcc 60gtcgtctttt cttcttctcc
ttctcctttt gtacttcccc tccattcctt cagctggttc 120tcgcctccag
ctttcctttc tttctttccc tcccctttta ttcgagtaat cctgcagctc
180tgggaggtgc aacagtcaca atgagcggac gtgagtcttg cacgcgatcg
ctgccatctc 240cgcgacagcg ttccatcctt tacctcaatg gatcagcaaa
tgctgatact cgattctagt 300ccggtttctc gatctcatca agcccttcac
gcccctcctc ccggaggtgg ccgccccgga 360aaccaaggtt cccttcaacc
agaagttgat gtggacgggg gtacgtgata cttgtccagc 420tcgacatgag
cttctaagct aatggattac ccctgcagtt gaccctattg atcttcctgg
480tcatgagcca gatgcccttg tacggaattg tctcctctga cacctccgac
cctctgtact 540ggctccgtat gatgttggcc agtaaccggg gtaccctgat
ggaactgggt atcaccccca 600tcatctcctc tggcatggtt ttccaggtat
gtaatgggga aattgcaatc tgatcacgga 660tatcgggcat ttgctaatat
gtggcttttg tctgatagct tctcgctggt acccacctca 720tcgatgtcaa
cctggacctg aagaccgacc gtgaactgta tcagaccgct cagaagctct
780tcgctatcat cctgtccttc ggtcaggcct gcgtctacgt cctcactggt
ctttacggcc 840agcccagtga ccttggtgcc ggtatctgtg ttctgctgat
tgttcagctg gtcgttgctg 900gcttggttgt catcctgctg gatgagctgc
tccagaaggg ctatggtctt ggtagcggta 960tctctctgtt catcgcgacc
aacatctgcg agtcgatcgt ctggaaggct ttctctccta 1020cgaccatcaa
cactggccgt ggtcccgagt ttgagggtgc catcattgcc ctcttccacc
1080ttctgttgac ctggtccgac aagcagcgcg ctctccgcga ggctttctac
cgccagaacc 1140tccccaacat catgaacctg ctggctactc tcctcgtttt
cgccgctgtg atctacctcc 1200agggcttccg tgttgagatc cctgtcaagt
cctcccgcca gcgtggcatg cgtggttcct 1260accctgttcg cctgttctac
acctccaaca tgcccatcat gcttcagtct gctctgtgct 1320ccaacatctt
cctcatcagt cagatgctgt actctcgctt ctctgacaac ctccttgtca
1380agcttctcgg tgtttgggag cctcgtgagg gttctgccca gctccacgcc
gcctccggca 1440ttgcctacta catgtctcct cccctgaact tcaaggaggc
ccttcttgac cccattcaca 1500ccgccgttta catcaccttc atgctggttg
cttgtgctct cttctggaag acctggattg 1560aggtttccgg ctctgctccc
cgcgatgttg ccaagcagct caaggaccag ggtctcgtga 1620tggctggtca
ccgtgagcag agcatgtaca aggagctcaa gcgcgtcatc cctactgctg
1680ctgctttcgg tggtgcctgc attggtgccc tgtccgtcgc ttctgacctg
cttggtgctc 1740ttggcagcgg tactggtatc ctccttgccg ttacgtaagt
cttcactttg gtctcagatt 1800ttctgaagtg gatactaaca ttcaaatgca
ggattatata cggatacttt gaaattgccg 1860cccgtgaggg cgacattgga
tcgggcctca agggccttgt tccgggtaac tagataaggc 1920cccctttttg
atgaaagcat gagaagaagt ttgagggctt atgtttgttc ttgcaacttt
1980ctgtttcttc tcaggtagtg tgctgttgtg gctgggatct ggattattta
gtttcttgat 2040ggatgtatgg ctagttttaa caatttgcag gaggggaaga
tcttctctac ggagatacgt 2100ccacgccaca gct 2113621437DNAAspergillus
nigerCDS(1)..(1437) 62atg agc gga ctc cgg ttt ctc gat ctc atc aag
ccc ttc acg ccc ctc 48Met Ser Gly Leu Arg Phe Leu Asp Leu Ile Lys
Pro Phe Thr Pro Leu 1 5 10 15 ctc ccg gag gtg gcc gcc ccg gaa acc
aag gtt ccc ttc aac cag aag 96Leu Pro Glu Val Ala Ala Pro Glu Thr
Lys Val Pro Phe Asn Gln Lys 20 25 30 ttg atg tgg acg ggg ttg acc
cta ttg atc ttc ctg gtc atg agc cag 144Leu Met Trp Thr Gly Leu Thr
Leu Leu Ile Phe Leu Val Met Ser Gln 35 40 45 atg ccc ttg tac gga
att gtc tcc tct gac acc tcc gac cct ctg tac 192Met Pro Leu Tyr Gly
Ile Val Ser Ser Asp Thr Ser Asp Pro Leu Tyr 50 55 60 tgg ctc cgt
atg atg ttg gcc agt aac cgg ggt acc ctg atg gaa ctg 240Trp Leu Arg
Met Met Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu 65 70 75 80 ggt
atc acc ccc atc atc tcc tct ggc atg gtt ttc cag ctt ctc gct 288Gly
Ile Thr Pro Ile Ile Ser Ser Gly Met Val Phe Gln Leu Leu Ala 85 90
95 ggt acc cac ctc atc gat gtc aac ctg gac ctg aag acc gac cgt gaa
336Gly Thr His Leu Ile Asp Val Asn Leu Asp Leu Lys Thr Asp Arg Glu
100 105 110 ctg tat cag acc gct cag aag ctc ttc gct atc atc ctg tcc
ttc ggt 384Leu Tyr Gln Thr Ala Gln Lys Leu Phe Ala Ile Ile Leu Ser
Phe Gly 115 120 125 cag gcc tgc gtc tac gtc ctc act ggt ctt tac ggc
cag ccc agt gac 432Gln Ala Cys Val Tyr Val Leu Thr Gly Leu Tyr Gly
Gln Pro Ser Asp 130 135 140 ctt ggt gcc ggt atc tgt gtt ctg ctg att
gtt cag ctg gtc gtt gct 480Leu Gly Ala Gly Ile Cys Val Leu Leu Ile
Val Gln Leu Val Val Ala 145 150 155 160 ggc ttg gtt gtc atc ctg ctg
gat gag ctg ctc cag aag ggc tat ggt 528Gly Leu Val Val Ile Leu Leu
Asp Glu Leu Leu Gln Lys Gly Tyr Gly 165 170 175 ctt ggt agc ggt atc
tct ctg ttc atc gcg acc aac atc tgc gag tcg 576Leu Gly Ser Gly Ile
Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Ser 180 185 190 atc gtc tgg
aag gct ttc tct cct acg acc atc aac act ggc cgt ggt 624Ile Val Trp
Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr Gly Arg Gly 195 200 205 ccc
gag ttt gag ggt gcc atc att gcc ctc ttc cac ctt ctg ttg acc 672Pro
Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Leu Thr 210 215
220 tgg tcc gac aag cag cgc gct ctc cgc gag gct ttc tac cgc cag aac
720Trp Ser Asp Lys Gln Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn
225 230 235 240 ctc ccc aac atc atg aac ctg ctg gct act ctc ctc gtt
ttc gcc gct 768Leu Pro Asn Ile Met Asn Leu Leu Ala Thr Leu Leu Val
Phe Ala Ala 245 250 255 gtg atc tac ctc cag ggc ttc cgt gtt gag atc
cct gtc aag tcc tcc 816Val Ile Tyr Leu Gln Gly Phe Arg Val Glu Ile
Pro Val Lys Ser Ser 260 265 270 cgc cag cgt ggc atg cgt ggt tcc tac
cct gtt cgc ctg ttc tac acc 864Arg Gln Arg Gly Met Arg Gly Ser Tyr
Pro Val Arg Leu Phe Tyr Thr 275 280 285 tcc aac atg ccc atc atg ctt
cag tct gct ctg tgc tcc aac atc ttc 912Ser Asn Met Pro Ile Met Leu
Gln Ser Ala Leu Cys Ser Asn Ile Phe 290 295 300 ctc atc agt cag atg
ctg tac tct cgc ttc tct gac aac ctc ctt gtc 960Leu Ile Ser Gln Met
Leu Tyr Ser Arg Phe Ser Asp Asn Leu Leu Val 305 310 315 320 aag ctt
ctc ggt gtt tgg gag cct cgt gag ggt tct gcc cag ctc cac 1008Lys Leu
Leu Gly Val Trp Glu Pro Arg Glu Gly Ser Ala Gln Leu His 325 330 335
gcc gcc tcc ggc att gcc tac tac atg tct cct ccc ctg aac ttc aag
1056Ala Ala Ser Gly Ile Ala Tyr Tyr Met Ser Pro Pro Leu Asn Phe Lys
340 345 350 gag gcc ctt ctt gac ccc att cac acc gcc gtt tac atc acc
ttc atg 1104Glu Ala Leu Leu Asp Pro Ile His Thr Ala Val Tyr Ile Thr
Phe Met 355 360 365 ctg gtt gct tgt gct ctc ttc tgg aag acc tgg att
gag gtt tcc ggc 1152Leu Val Ala Cys Ala Leu Phe Trp Lys Thr Trp Ile
Glu Val Ser Gly 370 375 380 tct gct ccc cgc gat gtt gcc aag cag ctc
aag gac cag ggt ctc gtg 1200Ser Ala Pro Arg Asp Val Ala Lys Gln Leu
Lys Asp Gln Gly Leu Val 385 390 395 400 atg gct ggt cac cgt gag cag
agc atg tac aag gag ctc aag cgc gtc 1248Met Ala Gly His Arg Glu Gln
Ser Met Tyr Lys Glu Leu Lys Arg Val 405 410 415 atc cct act gct gct
gct ttc ggt ggt gcc tgc att ggt gcc ctg tcc 1296Ile Pro Thr Ala Ala
Ala Phe Gly Gly Ala Cys Ile Gly Ala Leu Ser 420 425 430 gtc gct tct
gac ctg ctt ggt gct ctt ggc agc ggt act ggt atc ctc 1344Val Ala Ser
Asp Leu Leu Gly Ala Leu Gly Ser Gly Thr Gly Ile Leu 435 440 445 ctt
gcc gtt acg att ata tac gga tac ttt gaa att gcc gcc cgt gag 1392Leu
Ala Val Thr Ile Ile Tyr Gly Tyr Phe Glu Ile Ala Ala Arg Glu 450 455
460 ggc gac att gga tcg ggc ctc aag ggc ctt gtt ccg ggt aac tag
1437Gly Asp Ile Gly Ser Gly Leu Lys Gly Leu Val Pro Gly Asn 465 470
475 63478PRTAspergillus niger 63Met Ser Gly Leu Arg Phe Leu Asp Leu
Ile Lys Pro Phe Thr Pro Leu 1 5 10 15 Leu Pro Glu Val Ala Ala Pro
Glu Thr Lys Val Pro Phe Asn Gln Lys 20 25 30 Leu Met Trp Thr Gly
Leu Thr Leu Leu Ile Phe Leu Val Met Ser Gln 35 40 45 Met Pro Leu
Tyr Gly Ile Val Ser Ser Asp Thr Ser Asp Pro Leu Tyr 50 55 60 Trp
Leu Arg Met Met Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu 65 70
75 80 Gly Ile Thr Pro Ile Ile Ser Ser Gly Met Val Phe Gln Leu Leu
Ala 85 90 95 Gly Thr His Leu Ile Asp Val Asn Leu Asp Leu Lys Thr
Asp Arg Glu 100 105 110 Leu Tyr Gln Thr Ala Gln Lys Leu Phe Ala Ile
Ile Leu Ser Phe Gly 115 120 125 Gln Ala Cys Val Tyr Val Leu Thr Gly
Leu Tyr Gly Gln Pro Ser Asp 130 135 140 Leu Gly Ala Gly Ile Cys Val
Leu Leu Ile Val Gln Leu Val Val Ala 145 150 155 160 Gly Leu Val Val
Ile Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly 165 170 175 Leu Gly
Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Ser 180 185 190
Ile Val Trp Lys Ala Phe Ser Pro Thr Thr Ile Asn Thr Gly Arg Gly 195
200 205 Pro Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Leu
Thr 210 215 220 Trp Ser Asp Lys Gln Arg Ala Leu Arg Glu Ala Phe Tyr
Arg Gln Asn 225 230 235 240 Leu Pro Asn Ile Met Asn Leu Leu Ala Thr
Leu Leu Val Phe Ala Ala 245 250 255 Val Ile Tyr Leu Gln Gly Phe Arg
Val Glu Ile Pro Val Lys Ser Ser 260 265 270 Arg Gln Arg Gly Met Arg
Gly Ser Tyr Pro Val Arg Leu Phe Tyr Thr 275 280 285 Ser Asn Met Pro
Ile Met Leu Gln Ser Ala Leu Cys Ser Asn Ile Phe 290 295 300 Leu Ile
Ser Gln Met Leu Tyr Ser Arg Phe Ser Asp Asn Leu Leu Val 305 310 315
320 Lys Leu Leu Gly Val Trp Glu Pro Arg Glu Gly Ser Ala Gln Leu His
325
330 335 Ala Ala Ser Gly Ile Ala Tyr Tyr Met Ser Pro Pro Leu Asn Phe
Lys 340 345 350 Glu Ala Leu Leu Asp Pro Ile His Thr Ala Val Tyr Ile
Thr Phe Met 355 360 365 Leu Val Ala Cys Ala Leu Phe Trp Lys Thr Trp
Ile Glu Val Ser Gly 370 375 380 Ser Ala Pro Arg Asp Val Ala Lys Gln
Leu Lys Asp Gln Gly Leu Val 385 390 395 400 Met Ala Gly His Arg Glu
Gln Ser Met Tyr Lys Glu Leu Lys Arg Val 405 410 415 Ile Pro Thr Ala
Ala Ala Phe Gly Gly Ala Cys Ile Gly Ala Leu Ser 420 425 430 Val Ala
Ser Asp Leu Leu Gly Ala Leu Gly Ser Gly Thr Gly Ile Leu 435 440 445
Leu Ala Val Thr Ile Ile Tyr Gly Tyr Phe Glu Ile Ala Ala Arg Glu 450
455 460 Gly Asp Ile Gly Ser Gly Leu Lys Gly Leu Val Pro Gly Asn 465
470 475
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