U.S. patent application number 13/680995 was filed with the patent office on 2013-07-25 for composition for the diagnosis, prevention or treatment of diseases related to cells expressing il-8 or gro-alpha, comprising ucb-mscs. This patent application is currently assigned to Medipost Co., Ltd.. The applicant listed for this patent is Medipost Co., Ltd.. Invention is credited to Jong Wook Chang, Dal Soo Kim, Won II Oh, Yoon-Sun Yang.
Application Number | 20130189189 13/680995 |
Document ID | / |
Family ID | 40388015 |
Filed Date | 2013-07-25 |
United States Patent Application | 20130189189 |
Kind Code | A1 |
Chang; Jong Wook ; et al. | July 25, 2013 |
Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-.alpha. and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-.alpha., that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.
Inventors: | Chang; Jong Wook; (Seoul, KR) ; Kim; Dal Soo; (Seoul, KR) ; Yang; Yoon-Sun; (Seoul, KR) ; Oh; Won II; (Seoul, KR) | ||||||||||
Applicant: |
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Assignee: | Medipost Co., Ltd. Seoul KR |
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Family ID: | 40388015 | ||||||||||
Appl. No.: | 13/680995 | ||||||||||
Filed: | November 19, 2012 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12633622 | Dec 8, 2009 | |||
13680995 | ||||
PCT/KR2008/005026 | Aug 27, 2008 | |||
12633622 | ||||
61089733 | Aug 18, 2008 | |||
60972966 | Sep 17, 2007 | |||
Current U.S. Class: | 424/9.34 ; 424/9.1; 424/9.6; 424/93.21 |
Current CPC Class: | A61K 35/44 20130101; A61K 48/00 20130101; A61K 49/08 20130101; A61K 49/0002 20130101; A61K 49/0017 20130101; A61P 35/00 20180101 |
Class at Publication: | 424/9.34 ; 424/93.21; 424/9.1; 424/9.6 |
International Class: | A61K 49/08 20060101 A61K049/08; A61K 49/00 20060101 A61K049/00; A61K 48/00 20060101 A61K048/00 |
Date | Code | Application Number |
---|---|---|
Aug 29, 2007 | KR | 1020070087228 |
Jul 10, 2008 | KR | 1020080067247 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 110 <210> SEQ ID NO 1 <211> LENGTH: 20 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct
<400> SEQUENCE: 1 accacagtcc atgccatcac 20 <210> SEQ ID
NO 2 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct <400> SEQUENCE: 2
tccaccaccc tgttgctgta 20 <210> SEQ ID NO 3 <211>
LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct <400> SEQUENCE: 3 tcctgatttc tgcagctctg
tg 22 <210> SEQ ID NO 4 <211> LENGTH: 22 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic construct
<400> SEQUENCE: 4 tgcttgaagt ttcactggca tc 22 <210> SEQ
ID NO 5 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic construct <400> SEQUENCE: 5
gagccccgaa tctgacatta 20 <210> SEQ ID NO 6 <211>
LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic construct <400> SEQUENCE: 6 gcagacactg caacacacct
20 <210> SEQ ID NO 7 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct <400>
SEQUENCE: 7 attctgggca tccttcacag 20 <210> SEQ ID NO 8
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct <400> SEQUENCE: 8 tgcacttagg
caggaggtct 20 <210> SEQ ID NO 9 <211> LENGTH: 403
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 9 Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg
Asn Lys Arg Arg Tyr 1 5 10 15 Gln Glu Asp Gly Phe Asp Leu Asp Leu
Thr Tyr Ile Tyr Pro Asn Ile 20 25 30 Ile Ala Met Gly Phe Pro Ala
Glu Arg Leu Glu Gly Val Tyr Arg Asn 35 40 45 Asn Ile Asp Asp Val
Val Arg Phe Leu Asp Ser Lys His Lys Asn His 50 55 60 Tyr Lys Ile
Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 65 70 75 80 Phe
Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 85 90
95 Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu
100 105 110 Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala
Gly Lys 115 120 125 Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu
His Arg Gly Lys 130 135 140 Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe
Tyr Gly Glu Val Arg Thr 145 150 155 160 Arg Asp Lys Lys Gly Val Thr
Ile Pro Ser Gln Arg Arg Tyr Val Tyr 165 170 175 Tyr Tyr Ser Tyr Leu
Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 180 185 190 Leu Leu Phe
His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 195 200 205 Gly
Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 210 215
220 Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr
225 230 235 240 Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile
Lys Val Glu 245 250 255 Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys
Asp Lys Met Phe His 260 265 270 Phe Trp Val Asn Thr Phe Phe Ile Pro
Gly Pro Glu Glu Thr Ser Glu 275 280 285 Lys Val Glu Asn Gly Ser Leu
Cys Asp Gln Glu Ile Asp Ser Ile Cys 290 295 300 Ser Ile Glu Arg Ala
Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 305 310 315 320 Thr Lys
Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 325 330 335
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 340
345 350 Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro
Asp 355 360 365 Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp
Thr Thr Asp 370 375 380 Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp
Gln His Thr Gln Ile 385 390 395 400 Thr Lys Val <210> SEQ ID
NO 10 <211> LENGTH: 375 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 10 Met Asp Ala Leu Gln
Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 1 5 10 15 Lys Gln Leu
Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 20 25 30 Ile
Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 35 40
45 Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys
50 55 60 Asp Val Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn
Lys Leu 65 70 75 80 Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu
Tyr Val Asp Lys 85 90 95 Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser
Ser Thr Lys Arg Pro Tyr 100 105 110 Ala Lys Glu Leu Glu Thr Val Asp
Phe Lys Asp Lys Leu Glu Glu Thr 115 120 125 Lys Gly Gln Ile Asn Asn
Ser Ile Lys Asp Leu Thr Asp Gly His Phe 130 135 140 Glu Asn Ile Leu
Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 145 150 155 160 Val
Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Ser 165 170
175 Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Val Asn Lys Thr Asp Thr
180 185 190 Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met
Gly Asn 195 200 205 Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro
Phe Gln Asn Lys 210 215 220 His Leu Ser Met Phe Ile Leu Leu Pro Lys
Asp Val Glu Asp Glu Ser 225 230 235 240 Thr Gly Leu Glu Lys Ile Glu
Lys Gln Leu Asn Ser Glu Ser Leu Ser 245 250 255 Gln Trp Thr Asn Pro
Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 260 265 270 Ile Pro Lys
Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 275 280 285 Glu
Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 290 295
300 Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His
305 310 315 320 Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser
Ile Glu Val 325 330 335 Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu
Leu Asn Ala Asp His 340 345 350 Pro Phe Ile Tyr Ile Ile Arg His Asn
Lys Thr Arg Asn Ile Ile Phe 355 360 365 Phe Gly Lys Phe Cys Ser Pro
370 375 <210> SEQ ID NO 11 <211> LENGTH: 429
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 11 Met Ala Ser Asn Ser Ile Phe Asp Ser Phe
Pro Thr Tyr Ser Pro Thr 1 5 10 15 Phe Ile Arg Asp Pro Ser Thr Ser
Arg Arg Phe Thr Pro Pro Ser Pro 20 25 30 Ala Phe Pro Cys Gly Gly
Gly Gly Gly Lys Met Gly Glu Asn Ser Gly 35 40 45 Ala Leu Ser Ala
Gln Ala Ala Val Gly Pro Gly Gly Arg Ala Arg Pro 50 55 60 Glu Val
Arg Ser Met Val Asp Val Leu Ala Asp His Ala Gly Glu Leu 65 70 75 80
Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser His 85
90 95 Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala
Leu 100 105 110 Gly Asp Val Pro Asp Gly Thr Val Val Thr Val Met Ala
Gly Asn Asp 115 120 125 Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser
Ala Val Met Lys Asn 130 135 140 Gln Val Ala Arg Phe Asn Asp Leu Arg
Phe Val Gly Arg Ser Gly Arg 145 150 155 160 Gly Lys Ser Phe Thr Leu
Thr Ile Thr Val Phe Thr Asn Pro Thr Gln 165 170 175 Val Ala Thr Tyr
His Arg Ala Ile Lys Val Thr Val Asp Gly Pro Arg 180 185 190 Glu Pro
Arg Arg His Arg Gln Lys Leu Glu Asp Gln Thr Lys Pro Phe 195 200 205
Pro Asp Arg Phe Gly Asp Leu Glu Arg Leu Arg Met Arg Val Thr Pro 210
215 220 Ser Thr Pro Ser Pro Arg Gly Ser Leu Ser Thr Thr Ser His Phe
Ser 225 230 235 240 Ser Gln Pro Gln Thr Pro Ile Gln Gly Thr Ser Glu
Leu Asn Pro Phe 245 250 255 Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe
Pro Thr Leu Pro Thr Leu 260 265 270 Thr Glu Ser Arg Phe Pro Asp Pro
Arg Met His Tyr Pro Gly Ala Met 275 280 285 Ser Ala Ala Phe Pro Tyr
Ser Ala Thr Pro Ser Gly Thr Ser Ile Ser 290 295 300 Ser Leu Ser Val
Ala Gly Met Pro Ala Thr Ser Arg Phe His His Thr 305 310 315 320 Tyr
Leu Pro Pro Pro Tyr Pro Gly Ala Pro Gln Asn Gln Ser Gly Pro 325 330
335 Phe Gln Ala Asn Pro Ser Pro Tyr His Leu Tyr Tyr Gly Thr Ser Ser
340 345 350 Gly Ser Tyr Gln Phe Ser Met Val Ala Gly Ser Ser Ser Gly
Gly Asp 355 360 365 Arg Ser Pro Thr Arg Met Leu Ala Ser Cys Thr Ser
Ser Ala Ala Ser 370 375 380 Val Ala Ala Gly Asn Leu Met Asn Pro Ser
Leu Gly Gly Gln Ser Asp 385 390 395 400 Gly Val Glu Ala Asp Gly Ser
His Ser Asn Ser Pro Thr Ala Leu Ser 405 410 415 Thr Pro Gly Arg Met
Asp Glu Ala Val Trp Arg Pro Tyr 420 425 <210> SEQ ID NO 12
<211> LENGTH: 415 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 12 Met Arg Ile Pro Val Asp Pro
Ser Thr Ser Arg Arg Phe Thr Pro Pro 1 5 10 15 Ser Pro Ala Phe Pro
Cys Gly Gly Gly Gly Gly Lys Met Gly Glu Asn 20 25 30 Ser Gly Ala
Leu Ser Ala Gln Ala Ala Val Gly Pro Gly Gly Arg Ala 35 40 45 Arg
Pro Glu Val Arg Ser Met Val Asp Val Leu Ala Asp His Ala Gly 50 55
60 Glu Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro
65 70 75 80 Ser His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys
Val Val 85 90 95 Ala Leu Gly Asp Val Pro Asp Gly Thr Val Val Thr
Val Met Ala Gly 100 105 110 Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg
Asn Ala Ser Ala Val Met 115 120 125 Lys Asn Gln Val Ala Arg Phe Asn
Asp Leu Arg Phe Val Gly Arg Ser 130 135 140 Gly Arg Gly Lys Ser Phe
Thr Leu Thr Ile Thr Val Phe Thr Asn Pro 145 150 155 160 Thr Gln Val
Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly 165 170 175 Pro
Arg Glu Pro Arg Arg His Arg Gln Lys Leu Glu Asp Gln Thr Lys 180 185
190 Pro Phe Pro Asp Arg Phe Gly Asp Leu Glu Arg Leu Arg Met Arg Val
195 200 205 Thr Pro Ser Thr Pro Ser Pro Arg Gly Ser Leu Ser Thr Thr
Ser His 210 215 220 Phe Ser Ser Gln Pro Gln Thr Pro Ile Gln Gly Thr
Ser Glu Leu Asn 225 230 235 240 Pro Phe Ser Asp Pro Arg Gln Phe Asp
Arg Ser Phe Pro Thr Leu Pro 245 250 255 Thr Leu Thr Glu Ser Arg Phe
Pro Asp Pro Arg Met His Tyr Pro Gly 260 265 270 Ala Met Ser Ala Ala
Phe Pro Tyr Ser Ala Thr Pro Ser Gly Thr Ser 275 280 285 Ile Ser Ser
Leu Ser Val Ala Gly Met Pro Ala Thr Ser Arg Phe His 290 295 300 His
Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ala Pro Gln Asn Gln Ser 305 310
315 320 Gly Pro Phe Gln Ala Asn Pro Ser Pro Tyr His Leu Tyr Tyr Gly
Thr 325 330 335 Ser Ser Gly Ser Tyr Gln Phe Ser Met Val Ala Gly Ser
Ser Ser Gly 340 345 350 Gly Asp Arg Ser Pro Thr Arg Met Leu Ala Ser
Cys Thr Ser Ser Ala 355 360 365 Ala Ser Val Ala Ala Gly Asn Leu Met
Asn Pro Ser Leu Gly Gly Gln 370 375 380 Ser Asp Gly Val Glu Ala Asp
Gly Ser His Ser Asn Ser Pro Thr Ala 385 390 395 400 Leu Ser Thr Pro
Gly Arg Met Asp Glu Ala Val Trp Arg Pro Tyr 405 410 415 <210>
SEQ ID NO 13 <211> LENGTH: 178 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 13 Met Ser
Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 1 5 10 15
Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 20
25 30 Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys
Glu 35 40 45 Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp
Asp Val Val 50 55 60 Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro
Glu Gly Thr His Ser 65 70 75 80 Phe Asp Gly Ile Trp Lys Ala Ser Phe
Thr Thr Phe Thr Val Thr Lys 85 90 95 Tyr Trp Phe Tyr Arg Leu Leu
Ser Ala Leu Phe Gly Ile Pro Met Ala 100 105 110 Leu Ile Trp Gly Ile
Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 115 120 125 Ala Val Val
Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 130 135 140 Ser
Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 145 150
155 160 Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln
Lys 165 170 175 Glu Ile <210> SEQ ID NO 14 <211>
LENGTH: 177 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 14 Met Val Leu Leu Ser Thr Leu Gly
Ile Val Phe Gln Gly Glu Gly Pro 1 5 10 15 Pro Ile Ser Ser Cys Asp
Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 20 25 30 Phe Ile Ala Ile
Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 35 40 45 Ile Ile
Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 50 55 60
Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 65
70 75 80 Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His
Ser Gly 85 90 95 Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val
Val Lys Thr Gly 100 105 110 Arg Val Met Leu Gly Glu Thr Asn Pro Ala
Asp Ser Lys Pro Gly Thr 115 120 125 Ile Arg Gly Asp Phe Cys Ile Gln
Val Gly Arg Asn Ile Ile His Gly 130 135 140 Ser Asp Ser Val Glu Ser
Ala Glu Lys Glu Ile Gly Leu Trp Phe His 145 150 155 160 Pro Glu Glu
Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 165 170 175 Glu
<210> SEQ ID NO 15 <211> LENGTH: 152 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 15 Met
Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 1 5 10
15 Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly
20 25 30 Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp
Leu Leu 35 40 45 Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe
Phe Ala Gly Leu 50 55 60 Val Lys Tyr Met His Ser Gly Pro Val Val
Ala Met Val Trp Glu Gly 65 70 75 80 Leu Asn Val Val Lys Thr Gly Arg
Val Met Leu Gly Glu Thr Asn Pro 85 90 95 Ala Asp Ser Lys Pro Gly
Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 100 105 110 Gly Arg Asn Ile
Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 115 120 125 Glu Ile
Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 130 135 140
Cys Ala Gln Asn Trp Ile Tyr Glu 145 150 <210> SEQ ID NO 16
<211> LENGTH: 928 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 16 Met Pro Pro Lys Thr Pro Arg
Lys Thr Ala Ala Thr Ala Ala Ala Ala 1 5 10 15 Ala Ala Glu Pro Pro
Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 20 25 30 Pro Glu Gln
Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 35 40 45 Phe
Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 50 55
60 Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys
65 70 75 80 Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys
Lys Lys 85 90 95 Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val
Asp Leu Asp Glu 100 105 110 Met Ser Phe Thr Phe Thr Glu Leu Gln Lys
Asn Ile Glu Ile Ser Val 115 120 125 His Lys Phe Phe Asn Leu Leu Lys
Glu Ile Asp Thr Ser Thr Lys Val 130 135 140 Asp Asn Ala Met Ser Arg
Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 145 150 155 160 Leu Phe Ser
Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 165 170 175 Pro
Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 180 185
190 Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met
195 200 205 Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val
Leu Asp 210 215 220 Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys
Glu Pro Tyr Lys 225 230 235 240 Thr Ala Val Ile Pro Ile Asn Gly Ser
Pro Arg Thr Pro Arg Arg Gly 245 250 255 Gln Asn Arg Ser Ala Arg Ile
Ala Lys Gln Leu Glu Asn Asp Thr Arg 260 265 270 Ile Ile Glu Val Leu
Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 275 280 285 Lys Asn Val
Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 290 295 300 Leu
Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 305 310
315 320 Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu
Phe 325 330 335 Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp
Ser Phe Glu 340 345 350 Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp
Glu Glu Val Asn Val 355 360 365 Ile Pro Pro His Thr Pro Val Arg Thr
Val Met Asn Thr Ile Gln Gln 370 375 380 Leu Met Met Ile Leu Asn Ser
Ala Ser Asp Gln Pro Ser Glu Asn Leu 385 390 395 400 Ile Ser Tyr Phe
Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 405 410 415 Lys Arg
Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 420 425 430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 435
440 445 Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser
Glu 450 455 460 Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu
Asn Asp Asn 465 470 475 480 Ile Phe His Met Ser Leu Leu Ala Cys Ala
Leu Glu Val Val Met Ala 485 490 495 Thr Tyr Ser Arg Ser Thr Ser Gln
Asn Leu Asp Ser Gly Thr Asp Leu 500 505 510 Ser Phe Pro Trp Ile Leu
Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 515 520 525 Tyr Lys Val Ile
Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 530 535 540 Glu Met
Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 545 550 555
560 Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser
565 570 575 Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys
Pro Leu 580 585 590 Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp
Met Tyr Leu Ser 595 600 605 Pro Val Arg Ser Pro Lys Lys Lys Gly Ser
Thr Thr Arg Val Asn Ser 610 615 620 Thr Ala Asn Ala Glu Thr Gln Ala
Thr Ser Ala Phe Gln Thr Gln Lys 625 630 635 640 Pro Leu Lys Ser Thr
Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 645 650 655 Leu Ala Tyr
Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 660 665 670 His
Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 675 680
685 Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met
690 695 700 Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp
Leu Lys 705 710 715 720 Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu
Pro His Ala Val Gln 725 730 735 Glu Thr Phe Lys Arg Val Leu Ile Lys
Glu Glu Glu Tyr Asp Ser Ile 740 745 750 Ile Val Phe Tyr Asn Ser Val
Phe Met Gln Arg Leu Lys Thr Asn Ile 755 760 765 Leu Gln Tyr Ala Ser
Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 770 775 780 Ile Pro Arg
Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 785 790 795 800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 805
810 815 Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile
Leu 820 825 830 Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe
Gln Lys Ile 835 840 845 Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu
Lys Arg Ser Ala Glu 850 855 860 Gly Ser Asn Pro Pro Lys Pro Leu Lys
Lys Leu Arg Phe Asp Ile Glu 865 870 875 880 Gly Ser Asp Glu Ala Asp
Gly Ser Lys His Leu Pro Gly Glu Ser Lys 885 890 895 Phe Gln Gln Lys
Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 900 905 910 Lys Gln
Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 915 920 925
<210> SEQ ID NO 17 <211> LENGTH: 1043 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 Met
Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 1 5 10
15 Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr
20 25 30 Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile
Ser Val 35 40 45 Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu
Phe Ile Ala Lys 50 55 60 Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys
Pro His Ile Tyr Ala Leu 65 70 75 80 Ala Asn Val Ala Tyr Gln Ser Leu
Arg Asp Arg Asp Arg Asp Gln Cys 85 90 95 Ile Leu Ile Thr Gly Glu
Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 100 105 110 Leu Val Met Ser
Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 115 120 125 Asn Ser
Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 130 135 140
Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 145
150 155 160 Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu
Gly Gly 165 170 175 Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu
Val Lys Gln Leu 180 185 190 Lys Gly Glu Arg Asn Phe His Ile Phe Tyr
Gln Leu Leu Ala Gly Ala 195 200 205 Asp Glu Gln Leu Leu Lys Ala Leu
Lys Leu Glu Arg Asp Thr Thr Gly 210 215 220 Tyr Ala Tyr Leu Asn His
Glu Val Ser Arg Val Asp Gly Met Asp Asp 225 230 235 240 Ala Ser Ser
Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 245 250 255 Ser
Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 260 265
270 Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile
275 280 285 Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile
Gly Glu 290 295 300 Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala
Leu Cys Ser Arg 305 310 315 320 Thr Met Glu Thr Ala Lys Glu Lys Val
Val Thr Ala Leu Asn Val Met 325 330 335 Gln Ala Gln Tyr Ala Arg Asp
Ala Leu Ala Lys Asn Ile Tyr Ser Arg 340 345 350 Leu Phe Asp Trp Ile
Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 355 360 365 Ile Gly Glu
Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 370 375 380 Glu
Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 385 390
395 400 Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu
Glu 405 410 415 Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys
Val Asp Tyr 420 425 430 Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu
His Asn Gln Arg Gly 435 440 445 Ile Leu Ala Met Leu Asp Glu Glu Cys
Leu Arg Pro Gly Val Val Ser 450 455 460 Asp Ser Thr Phe Leu Ala Lys
Leu Asn Gln Leu Phe Ser Lys His Gly 465 470 475 480 His Tyr Glu Ser
Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 485 490 495 Thr Met
Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 500 505 510
Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 515
520 525 Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu
Arg 530 535 540 Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu
Lys Arg Pro 545 550 555 560 Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser
Val Ala Ile Leu Met Lys 565 570 575 Asn Leu Tyr Ser Lys Ser Pro Asn
Tyr Ile Arg Cys Ile Lys Pro Asn 580 585 590 Glu His Gln Gln Arg Gly
Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 595 600 605 Ala Arg Tyr Leu
Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 610 615 620 Tyr Ala
His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 625 630 635
640 Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly
645 650 655 Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu
Leu Ala 660 665 670 Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys
Thr Leu Phe Tyr 675 680 685 Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln
Gln Leu Ala Thr Leu Ile 690 695 700 Gln Lys Ile Tyr Arg Gly Trp Arg
Cys Arg Thr His Tyr Gln Leu Met 705 710 715 720 Arg Lys Ser Gln Ile
Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 725 730 735 Lys Lys Cys
Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 740 745 750 Phe
Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 755 760
765 Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val
770 775 780 Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr
Asn Val 785 790 795 800 Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys
Cys Leu Ser Thr Ala 805 810 815 Asn Gln Glu Leu Gln Gln Leu Phe Tyr
Gln Trp Lys Cys Lys Arg Phe 820 825 830 Arg Asp Gln Leu Ser Pro Lys
Gln Val Glu Ile Leu Arg Glu Lys Leu 835 840 845 Cys Ala Ser Glu Leu
Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 850 855 860 Val Pro Ile
Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 865 870 875 880
Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 885
890 895 Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser
Arg 900 905 910 Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp
Thr Lys Lys 915 920 925 Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn
Val Ala Gly Val Ser 930 935 940 Val Thr Ser Leu Lys Asp Gly Leu Phe
Ser Leu His Leu Ser Glu Met 945 950 955 960 Ser Ser Val Gly Ser Lys
Gly Asp Phe Leu Leu Val Ser Glu His Val 965 970 975 Ile Glu Leu Leu
Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 980 985 990 Arg Gln
Leu Thr Val Thr Val Thr Glu Lys Phe Ser Val Arg Phe Lys 995 1000
1005 Glu Asn Ser Val Ala Val Lys Val Val Gln Gly Pro Ala Gly Gly
Asp 1010 1015 1020 Asn Ser Lys Leu Arg Tyr Lys Lys Lys Gly Ser His
Cys Leu Glu Val 1025 1030 1035 1040 Thr Val Gln <210> SEQ ID
NO 18 <211> LENGTH: 248 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Ala Ala Gly Met
Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe
Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln
Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40
45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu
50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe
Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met
Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg
Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp
Tyr Asp Ser Ser Ser Ser Lys Gly 115 120 125 Lys Lys Ser Arg Thr Gln
Lys Glu Lys Lys Ala Ala Arg Ala Arg Ser 130 135 140 Lys Gly Lys Asn
Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys Lys 145 150 155 160 Leu
Lys Leu Val Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val Thr 165 170
175 Phe Gly Ser Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp Pro
180 185 190 Asn Glu Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly
Glu Met 195 200 205 Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp
Phe His Phe Ala 210 215 220 Cys Val Gly Leu Thr Thr Lys Pro Arg Gly
Lys Trp Phe Cys Pro Arg 225 230 235 240 Cys Ser Gln Glu Arg Lys Lys
Lys 245 <210> SEQ ID NO 19 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 19 Met Ala Ala Gly Met Tyr Leu Glu His Tyr
Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe Glu Leu Gln Arg Asn
Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln Arg Thr Glu Asp Leu
Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40 45 Tyr Met Ser Ser
Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 50 55 60 Leu Lys
Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 65 70 75 80
Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 85
90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu
Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser
Ser Lys Glu 115 120 125 Gly Arg Thr Gln Lys Glu Lys Lys Ala Ala Arg
Ala Arg Ser Lys Gly 130 135 140 Lys Asn Ser Asp Glu Glu Ala Pro Lys
Thr Ala Gln Lys Lys Leu Lys 145 150 155 160 Leu Val Arg Thr Ser Pro
Glu Tyr Gly Met Pro Ser Val Thr Phe Gly 165 170 175 Ser Val His Pro
Ser Asp Val Leu Asp Met Pro Val Asp Pro Asn Glu 180 185 190 Pro Thr
Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu Met Ile Gly 195 200 205
Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe Ala Cys Val 210
215 220 Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe Cys Pro Arg Cys
Ser 225 230 235 240 Gln Glu Arg Lys Lys Lys 245 <210> SEQ ID
NO 20 <211> LENGTH: 245 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 20 Met Ala Ala Gly Met
Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe
Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln
Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40
45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu
50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe
Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met
Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg
Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp
Tyr Asp Ser Ser Ser Ser Lys Gly 115 120 125 Arg Thr Gln Lys Glu Lys
Lys Ala Ala Arg Ala Arg Ser Lys Gly Lys 130 135 140 Asn Ser Asp Glu
Glu Ala Pro Lys Thr Ala Gln Lys Lys Leu Lys Leu 145 150 155 160 Val
Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val Thr Phe Gly Ser 165 170
175 Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp Pro Asn Glu Pro
180 185 190 Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu Met Ile
Gly Cys 195 200 205 Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe
Ala Cys Val Gly 210 215 220 Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe
Cys Pro Arg Cys Ser Gln 225 230 235 240 Glu Arg Lys Lys Lys 245
<210> SEQ ID NO 21 <211> LENGTH: 225 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 Met
Ala Ala Gly Met Tyr Leu Glu His Tyr Leu Asp Asn Leu Lys Ala 1 5 10
15 Glu Ile Asp Lys Leu Ala Thr Glu Tyr Met Ser Ser Ala Arg Ser Leu
20 25 30 Ser Ser Glu Glu Lys Leu Ala Leu Leu Lys Gln Ile Gln Glu
Ala Tyr 35 40 45 Gly Lys Cys Lys Glu Phe Gly Asp Asp Lys Val Gln
Leu Ala Met Gln 50 55 60 Thr Tyr Glu Met Val Asp Lys His Ile Arg
Arg Leu Asp Thr Asp Leu 65 70 75 80 Ala Arg Phe Glu Ala Asp Leu Lys
Glu Lys Gln Ile Glu Ser Ser Asp 85 90 95 Tyr Asp Ser Ser Ser Ser
Lys Gly Lys Lys Lys Gly Arg Thr Gln Lys 100 105 110 Glu Lys Lys Ala
Ala Arg Ala Arg Ser Lys Gly Lys Asn Ser Asp Glu 115 120 125 Glu Ala
Pro Lys Thr Ala Gln Lys Lys Leu Lys Leu Val Arg Thr Ser 130 135 140
Pro Glu Tyr Gly Met Pro Ser Val Thr Phe Gly Ser Val His Pro Ser 145
150 155 160 Asp Val Leu Asp Met Pro Val Asp Pro Asn Glu Pro Thr Tyr
Cys Leu 165 170 175 Cys His Gln Val Ser Tyr Gly Glu Met Ile Gly Cys
Asp Asn Pro Asp 180 185 190 Cys Ser Ile Glu Trp Phe His Phe Ala Cys
Val Gly Leu Thr Thr Lys 195 200 205 Pro Arg Gly Lys Trp Phe Cys Pro
Arg Cys Ser Gln Glu Arg Lys Lys 210 215 220 Lys 225 <210> SEQ
ID NO 22 <211> LENGTH: 179 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 22 Met Ala Ala Gly Met
Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe
Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln
Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40
45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu
50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe
Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met
Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg
Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp
Tyr Asp Ser Ser Ser Ser Lys Gly 115 120 125 Lys Lys Lys Gly Arg Thr
Gln Lys Glu Lys Lys Ala Ala Arg Ala Arg 130 135 140 Ser Lys Gly Lys
Asn Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys 145 150 155 160 Lys
Leu Lys Leu Val Arg Thr Val Pro Leu Ser Gly Ser Ile Leu Pro 165 170
175 Val Trp Gly <210> SEQ ID NO 23 <211> LENGTH: 249
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 23 Met Ala Ala Gly Met Tyr Leu Glu His Tyr
Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe Glu Leu Gln Arg Asn
Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln Arg Thr Glu Asp Leu
Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40 45 Tyr Met Ser Ser
Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 50 55 60 Leu Lys
Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 65 70 75 80
Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 85
90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu
Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser
Ser Lys Gly 115 120 125 Lys Lys Lys Gly Arg Thr Gln Lys Glu Lys Lys
Ala Ala Arg Ala Arg 130 135 140 Ser Lys Gly Lys Asn Ser Asp Glu Glu
Ala Pro Lys Thr Ala Gln Lys 145 150 155 160 Lys Leu Lys Leu Val Arg
Thr Ser Pro Glu Tyr Gly Met Pro Ser Val 165 170 175 Thr Phe Gly Ser
Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp 180 185 190 Pro Asn
Glu Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu 195 200 205
Met Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe 210
215 220 Ala Cys Val Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe Cys
Pro 225 230 235 240 Arg Cys Ser Gln Glu Arg Lys Lys Lys 245
<210> SEQ ID NO 24 <211> LENGTH: 142 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 Met
Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 1 5 10
15 His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala
20 25 30 Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys
Pro Thr 35 40 45 Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys
Phe Lys Glu Leu 50 55 60 Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile
Glu Glu His Lys Lys His 65 70 75 80 Ser Ser Gly Cys Ala Phe Leu Ser
Val Lys Lys Gln Phe Glu Glu Leu 85 90 95 Thr Leu Gly Glu Phe Leu
Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 100 105 110 Ile Ala Lys Glu
Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 115 120 125 Glu Lys
Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 130 135 140
<210> SEQ ID NO 25 <211> LENGTH: 137 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 25 Met
Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 1 5 10
15 His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala
20 25 30 Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys
Pro Thr 35 40 45 Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys
Phe Lys Glu Leu 50 55 60 Glu Gly Trp Glu Pro Asp Asp Asp Pro Met
Gln Arg Lys Pro Thr Ile 65 70 75 80 Arg Arg Lys Asn Leu Arg Lys Leu
Arg Arg Lys Cys Ala Val Pro Ser 85 90 95 Ser Ser Trp Leu Pro Trp
Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 100 105 110 Pro Glu Trp Leu
His His Phe Gln Gly Leu Phe Pro Gly Ala Thr Ser 115 120 125 Leu Pro
Val Gly Pro Leu Ala Met Ser 130 135 <210> SEQ ID NO 26
<211> LENGTH: 165 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 26 Met Gly Ala Pro Thr Leu Pro
Pro Ala Trp Gln Pro Phe Leu Lys Asp 1 5 10 15 His Arg Ile Ser Thr
Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 20 25 30 Cys Thr Pro
Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 35 40 45 Glu
Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 50 55
60 Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala
65 70 75 80 Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg
Ile Thr 85 90 95 Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala
Phe Leu Ser Val 100 105 110 Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly
Glu Phe Leu Lys Leu Asp 115 120 125 Arg Glu Arg Ala Lys Asn Lys Ile
Ala Lys Glu Thr Asn Asn Lys Lys 130 135 140 Lys Glu Phe Glu Glu Thr
Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 145 150 155 160 Leu Ala Ala
Met Asp 165 <210> SEQ ID NO 27 <211> LENGTH: 497
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 27 Met Thr Phe Asn Ser Phe Glu Gly Ser Lys
Thr Cys Val Pro Ala Asp 1 5 10 15 Ile Asn Lys Glu Glu Glu Phe Val
Glu Glu Phe Asn Arg Leu Lys Thr 20 25 30 Phe Ala Asn Phe Pro Ser
Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 35 40 45 Arg Ala Gly Phe
Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 50 55 60 Ser Cys
His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 65 70 75 80
Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 85
90 95 Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln
Asn 100 105 110 Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp
His Phe Ala 115 120 125 Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr
Leu Leu Arg Thr Gly 130 135 140 Gln Val Val Asp Ile Ser Asp Thr Ile
Tyr Pro Arg Asn Pro Ala Met 145 150 155 160 Tyr Ser Glu Glu Ala Arg
Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 165 170 175 Ala His Leu Thr
Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 180 185 190 Gly Ile
Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 195 200 205
Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 210
215 220 Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser
Glu 225 230 235 240 Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn
Ser Thr Asn Leu 245 250 255 Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu
Ala Arg Ile Phe Thr Phe 260 265 270 Gly Thr Trp Ile Tyr Ser Val Asn
Lys Glu Gln Leu Ala Arg Ala Gly 275 280 285 Phe Tyr Ala Leu Gly Glu
Gly Asp Lys Val Lys Cys Phe His Cys Gly 290 295 300 Gly Gly Leu Thr
Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 305 310 315 320 Ala
Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 325 330
335 Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu
340 345 350 Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile
Asp Asp 355 360 365 Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile
Arg Met Gly Phe 370 375 380 Ser Phe Lys Asp Ile Lys Lys Ile Met Glu
Glu Lys Ile Gln Ile Ser 385 390 395 400 Gly Ser Asn Tyr Lys Ser Leu
Glu Val Leu Val Ala Asp Leu Val Asn 405 410 415 Ala Gln Lys Asp Ser
Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430 Lys Glu Ile
Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445 Leu
Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455
460 Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys
465 470 475 480 Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys
Ile Phe Met 485 490 495 Ser <210> SEQ ID NO 28 <211>
LENGTH: 1403 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 28 Met Ala Thr Gln Gln Lys Ala Ser
Asp Glu Arg Ile Ser Gln Phe Asp 1 5 10 15 His Asn Leu Leu Pro Glu
Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 20 25 30 Gln Leu Ala Lys
Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 35 40 45 Met Gln
Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 50 55 60
Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 65
70 75 80 Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly
Ile Gln 85 90 95 Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly
Leu Thr Arg Leu 100 105 110 Pro Ile Glu Asp His Lys Arg Phe His Pro
Asp Cys Gly Phe Leu Leu 115 120 125 Asn Lys Asp Val Gly Asn Ile Ala
Lys Tyr Asp Ile Arg Val Lys Asn 130 135 140 Leu Lys Ser Arg Leu Arg
Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 145 150 155 160 Ala Arg Leu
Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 165 170 175 Ser
Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 180 185
190 Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu
195 200 205 Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro
Lys Cys 210 215 220 Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile
Thr Gln Tyr Ile 225 230 235 240 Gln Ser Tyr Lys Gly Phe Val Asp Ile
Thr Gly Glu His Phe Val Asn 245 250 255 Ser Trp Val Gln Arg Glu Leu
Pro Met Ala Ser Ala Tyr Cys Asn Asp 260 265 270 Ser Ile Phe Ala Tyr
Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 275 280 285 Pro Arg Glu
Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 290 295 300 Phe
Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 305 310
315 320 Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His
Thr 325 330 335 Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys
Ser Ser Ala 340 345 350 Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu
Leu Cys Glu Leu Leu 355 360 365 Glu Thr Thr Ser Glu Ser Asn Leu Glu
Asp Ser Ile Ala Val Gly Pro 370 375 380 Ile Val Pro Glu Met Ala Gln
Gly Glu Ala Gln Trp Phe Gln Glu Ala 385 390 395 400 Lys Asn Leu Asn
Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 405 410 415 Arg His
Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 420 425 430
Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 435
440 445 Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn
Ser 450 455 460 Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr
Val Leu Leu 465 470 475 480 Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly
Cys Cys Pro Leu Leu Asn 485 490 495 Arg Phe Gln Leu Val Phe Tyr Leu
Ser Leu Ser Ser Thr Arg Pro Asp 500 505 510 Glu Gly Leu Ala Ser Ile
Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 515 520 525 Ser Val Thr Glu
Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn 530 535 540 Gln Val
Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 545 550 555
560 Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys
565 570 575 Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg
Arg Tyr 580 585 590 Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe
Tyr Asn Thr Val 595 600 605 Cys Ile Leu Arg Lys Leu Phe Ser His Asn
Met Thr Arg Leu Arg Lys 610 615 620 Phe Met Val Tyr Phe Gly Lys Asn
Gln Ser Leu Gln Lys Ile Gln Lys 625 630 635 640 Thr Pro Leu Phe Val
Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 645 650 655 Phe Asp Pro
Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 660 665 670 Arg
Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 675 680
685 Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys
690 695 700 Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp
Glu Asp 705 710 715 720 Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe
Thr Ala Gln Arg Leu 725 730 735 Arg Pro Phe Tyr Arg Phe Leu Ser Pro
Ala Phe Gln Glu Phe Leu Ala 740 745 750 Gly Met Arg Leu Ile Glu Leu
Leu Asp Ser Asp Arg Gln Glu His Gln 755 760 765 Asp Leu Gly Leu Tyr
His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 770 775 780 Val Ser Ala
Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 785 790 795 800
Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 805
810 815 Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu
Lys 820 825 830 His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg
Gly Leu Trp 835 840 845 Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val
Ser Glu His Leu Leu 850 855 860 Val Leu Ala Leu Lys Thr Ala Tyr Gln
Ser Asn Thr Val Ala Ala Cys 865 870 875 880 Ser Pro Phe Val Leu Gln
Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 885 890 895 Ala Leu Asn Leu
Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 900 905 910 Leu Arg
Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 915 920 925
Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 930
935 940 Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu
Trp 945 950 955 960 Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys
Ser Tyr Met Asp 965 970 975 Met Gln Arg Arg Ala Ser Pro Asp Leu Ser
Thr Gly Tyr Trp Lys Leu 980 985 990 Ser Pro Lys Gln Tyr Lys Ile Pro
Cys Leu Glu Val Asp Val Asn Asp 995 1000 1005 Ile Asp Val Val Gly
Gln Asp Met Leu Glu Ile Leu Met Thr Val Phe 1010 1015 1020 Ser Ala
Ser Gln Arg Ile Glu Leu His Leu Asn His Ser Arg Gly Phe 1025 1030
1035 1040 Ile Glu Ser Ile Arg Pro Ala Leu Glu Leu Ser Lys Ala Ser
Val Thr 1045 1050 1055 Lys Cys Ser Ile Ser Lys Leu Glu Leu Ser Ala
Ala Glu Gln Glu Leu 1060 1065 1070 Leu Leu Thr Leu Pro Ser Leu Glu
Ser Leu Glu Val Ser Gly Thr Ile 1075 1080 1085 Gln Ser Gln Asp Gln
Ile Phe Pro Asn Leu Asp Lys Phe Leu Cys Leu 1090 1095 1100 Lys Glu
Leu Ser Val Asp Leu Glu Gly Asn Ile Asn Val Phe Ser Val 1105 1110
1115 1120 Ile Pro Glu Glu Phe Pro Asn Phe His His Met Glu Lys Leu
Leu Ile 1125 1130 1135 Gln Ile Ser Ala Glu Tyr Asp Pro Ser Lys Leu
Val Lys Leu Ile Gln 1140 1145 1150 Asn Ser Pro Asn Leu His Val Phe
His Leu Lys Cys Asn Phe Phe Ser 1155 1160 1165 Asp Phe Gly Ser Leu
Met Thr Met Leu Val Ser Cys Lys Lys Leu Thr 1170 1175 1180 Glu Ile
Lys Phe Ser Asp Ser Phe Phe Gln Ala Val Pro Phe Val Ala 1185 1190
1195 1200 Ser Leu Pro Asn Phe Ile Ser Leu Lys Ile Leu Asn Leu Glu
Gly Gln 1205 1210 1215 Gln Phe Pro Asp Glu Glu Thr Ser Glu Lys Phe
Ala Tyr Ile Leu Gly 1220 1225 1230 Ser Leu Ser Asn Leu Glu Glu Leu
Ile Leu Pro Thr Gly Asp Gly Ile 1235 1240 1245 Tyr Arg Val Ala Lys
Leu Ile Ile Gln Gln Cys Gln Gln Leu His Cys 1250 1255 1260 Leu Arg
Val Leu Ser Phe Phe Lys Thr Leu Asn Asp Asp Ser Val Val 1265 1270
1275 1280 Glu Ile Ala Lys Val Ala Ile Ser Gly Gly Phe Gln Lys Leu
Glu Asn 1285 1290 1295 Leu Lys Leu Ser Ile Asn His Lys Ile Thr Glu
Glu Gly Tyr Arg Asn 1300 1305 1310 Phe Phe Gln Ala Leu Asp Asn Met
Pro Asn Leu Gln Glu Leu Asp Ile 1315 1320 1325 Ser Arg His Phe Thr
Glu Cys Ile Lys Ala Gln Ala Thr Thr Val Lys 1330 1335 1340 Ser Leu
Ser Gln Cys Val Leu Arg Leu Pro Arg Leu Ile Arg Leu Asn 1345 1350
1355 1360 Met Leu Ser Trp Leu Leu Asp Ala Asp Asp Ile Ala Leu Leu
Asn Val 1365 1370 1375 Met Lys Glu Arg His Pro Gln Ser Lys Tyr Leu
Thr Ile Leu Gln Lys 1380 1385 1390 Trp Ile Leu Pro Phe Ser Pro Ile
Ile Gln Lys 1395 1400 <210> SEQ ID NO 29 <211> LENGTH:
1241 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 29 Met Pro Leu His Ile Gly Asp Phe Val Trp
Asp Ser Lys Val His Ser 1 5 10 15 Leu Gln Ser Ser Leu Asn Ile Phe
Ser Leu Leu Pro Thr Lys Gly Arg 20 25 30 Thr Glu His Leu Phe Phe
Ser His Ile Leu Ser Phe His Trp Pro Ala 35 40 45 Phe Ser Ser Ile
Arg Leu Glu Leu Trp Ile Asn Leu Arg Cys Glu Phe 50 55 60 Leu Arg
Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile Gln Ser 65 70 75 80
Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn Ser Trp 85
90 95 Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp Ser
Ile 100 105 110 Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp
Trp Pro Arg 115 120 125 Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys
Ala Gly Leu Phe Tyr 130 135 140 Thr Gly Ile Lys Asp Ile Val Gln Cys
Phe Ser Cys Gly Gly Cys Leu 145 150 155 160 Glu Lys Trp Gln Glu Gly
Asp Asp Pro Leu Asp Asp His Thr Arg Cys 165 170 175 Phe Pro Asn Cys
Pro Phe Leu Gln Asn Met Lys Ser Ser Ala Glu Val 180 185 190 Thr Pro
Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu Glu Thr 195 200 205
Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro Ile Val 210
215 220 Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala Lys
Asn 225 230 235 240 Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala
Ser Phe Arg His 245 250 255 Met Ser Leu Leu Asp Ile Ser Ser Asp Leu
Ala Thr Asp His Leu Leu 260 265 270 Gly Cys Asp Leu Ser Ile Ala Ser
Lys His Ile Ser Lys Pro Val Gln 275 280 285 Glu Pro Leu Val Leu Pro
Glu Val Phe Gly Asn Leu Asn Ser Val Met 290 295 300 Cys Val Glu Gly
Glu Ala Gly Ser Gly Lys Thr Val Leu Leu Lys Lys 305 310 315 320 Ile
Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn Arg Phe 325 330
335 Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp Glu Gly
340 345 350 Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly
Ser Val 355 360 365 Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu
Lys Asn Gln Val 370 375 380 Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile
Cys Ser Ile Pro Gln Val 385 390 395 400 Ile Gly Lys Leu Ile Gln Lys
Asn His Leu Ser Arg Thr Cys Leu Leu 405 410 415 Ile Ala Val Arg Thr
Asn Arg Ala Arg Asp Ile Arg Arg Tyr Leu Glu 420 425 430 Thr Ile Leu
Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val Cys Ile 435 440 445 Leu
Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys Phe Met 450 455
460 Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys Thr Pro
465 470 475 480 Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr
Pro Phe Asp 485 490 495 Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser
Tyr Met Glu Arg Leu 500 505 510 Ser Leu Arg Asn Lys Ala Thr Ala Glu
Ile Leu Lys Ala Thr Val Ser 515 520 525 Ser Cys Gly Glu Leu Ala Leu
Lys Gly Phe Phe Ser Cys Cys Phe Glu 530 535 540 Phe Asn Asp Asp Asp
Leu Ala Glu Ala Gly Val Asp Glu Asp Glu Asp 545 550 555 560 Leu Thr
Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu Arg Pro 565 570 575
Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala Gly Met 580
585 590 Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln Asp
Leu 595 600 605 Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met
Thr Val Ser 610 615 620 Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser
Leu Pro Ser Thr Lys 625 630 635 640 Ala Gly Pro Lys Ile Val Ser His
Leu Leu His Leu Val Asp Asn Lys 645 650 655 Glu Ser Leu Glu Asn Ile
Ser Glu Asn Asp Asp Tyr Leu Lys His Gln 660 665 670 Pro Glu Ile Ser
Leu Gln Met Gln Leu Leu Arg Gly Leu Trp Gln Ile 675 680 685 Cys Pro
Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu Val Leu 690 695 700
Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys Ser Pro 705
710 715 720 Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly
Ala Leu 725 730 735 Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu
Ser Leu Leu Arg 740 745 750 Ser Ile His Phe Pro Ile Arg Gly Asn Lys
Thr Ser Pro Arg Ala His 755 760 765 Phe Ser Val Leu Glu Thr Cys Phe
Asp Lys Ser Gln Val Pro Thr Ile 770 775 780 Asp Gln Asp Tyr Ala Ser
Ala Phe Glu Pro Met Asn Glu Trp Glu Arg 785 790 795 800 Asn Leu Ala
Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp Met Gln 805 810 815 Arg
Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu Ser Pro 820 825
830 Lys Gln Tyr Lys Ile Pro Cys Leu Glu Val Asp Val Asn Asp Ile Asp
835 840 845 Val Val Gly Gln Asp Met Leu Glu Ile Leu Met Thr Val Phe
Ser Ala 850 855 860 Ser Gln Arg Ile Glu Leu His Leu Asn His Ser Arg
Gly Phe Ile Glu 865 870 875 880 Ser Ile Arg Pro Ala Leu Glu Leu Ser
Lys Ala Ser Val Thr Lys Cys 885 890 895 Ser Ile Ser Lys Leu Glu Leu
Ser Ala Ala Glu Gln Glu Leu Leu Leu 900 905 910 Thr Leu Pro Ser Leu
Glu Ser Leu Glu Val Ser Gly Thr Ile Gln Ser 915 920 925 Gln Asp Gln
Ile Phe Pro Asn Leu Asp Lys Phe Leu Cys Leu Lys Glu 930 935 940 Leu
Ser Val Asp Leu Glu Gly Asn Ile Asn Val Phe Ser Val Ile Pro 945 950
955 960 Glu Glu Phe Pro Asn Phe His His Met Glu Lys Leu Leu Ile Gln
Ile 965 970 975 Ser Ala Glu Tyr Asp Pro Ser Lys Leu Val Lys Leu Ile
Gln Asn Ser 980 985 990 Pro Asn Leu His Val Phe His Leu Lys Cys Asn
Phe Phe Ser Asp Phe 995 1000 1005 Gly Ser Leu Met Thr Met Leu Val
Ser Cys Lys Lys Leu Thr Glu Ile 1010 1015 1020 Lys Phe Ser Asp Ser
Phe Phe Gln Ala Val Pro Phe Val Ala Ser Leu 1025 1030 1035 1040 Pro
Asn Phe Ile Ser Leu Lys Ile Leu Asn Leu Glu Gly Gln Gln Phe 1045
1050 1055 Pro Asp Glu Glu Thr Ser Glu Lys Phe Ala Tyr Ile Leu Gly
Ser Leu 1060 1065 1070 Ser Asn Leu Glu Glu Leu Ile Leu Pro Thr Gly
Asp Gly Ile Tyr Arg 1075 1080 1085 Val Ala Lys Leu Ile Ile Gln Gln
Cys Gln Gln Leu His Cys Leu Arg 1090 1095 1100 Val Leu Ser Phe Phe
Lys Thr Leu Asn Asp Asp Ser Val Val Glu Ile 1105 1110 1115 1120 Ala
Lys Val Ala Ile Ser Gly Gly Phe Gln Lys Leu Glu Asn Leu Lys 1125
1130 1135 Leu Ser Ile Asn His Lys Ile Thr Glu Glu Gly Tyr Arg Asn
Phe Phe 1140 1145 1150 Gln Ala Leu Asp Asn Met Pro Asn Leu Gln Glu
Leu Asp Ile Ser Arg 1155 1160 1165 His Phe Thr Glu Cys Ile Lys Ala
Gln Ala Thr Thr Val Lys Ser Leu 1170 1175 1180 Ser Gln Cys Val Leu
Arg Leu Pro Arg Leu Ile Arg Leu Asn Met Leu 1185 1190 1195 1200 Ser
Trp Leu Leu Asp Ala Asp Asp Ile Ala Leu Leu Asn Val Met Lys 1205
1210 1215 Glu Arg His Pro Gln Ser Lys Tyr Leu Thr Ile Leu Gln Lys
Trp Ile 1220 1225 1230 Leu Pro Phe Ser Pro Ile Ile Gln Lys 1235
1240 <210> SEQ ID NO 30 <211> LENGTH: 233 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
30 Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala
1 5 10 15 Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys
Leu Phe 20 25 30 Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala
Thr Thr Leu Phe 35 40 45 Cys Leu Leu His Phe Gly Val Ile Gly Pro
Gln Arg Glu Glu Phe Pro 50 55 60 Arg Asp Leu Ser Leu Ile Ser Pro
Leu Ala Gln Ala Val Arg Ser Ser 65 70 75 80 Ser Arg Thr Pro Ser Asp
Lys Pro Val Ala His Val Val Ala Asn Pro 85 90 95 Gln Ala Glu Gly
Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 100 105 110 Leu Ala
Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 115 120 125
Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 130
135 140 Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile
Ala 145 150 155 160 Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala
Ile Lys Ser Pro 165 170 175 Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu
Ala Lys Pro Trp Tyr Glu 180 185 190 Pro Ile Tyr Leu Gly Gly Val Phe
Gln Leu Glu Lys Gly Asp Arg Leu 195 200 205 Ser Ala Glu Ile Asn Arg
Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 210 215 220 Gln Val Tyr Phe
Gly Ile Ile Ala Leu 225 230 <210> SEQ ID NO 31 <211>
LENGTH: 189 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 31 Met Ala Ser Pro Phe Ala Leu Leu
Met Val Leu Val Val Leu Ser Cys 1 5 10 15 Lys Ser Ser Cys Ser Leu
Gly Cys Asp Leu Pro Glu Thr His Ser Leu 20 25 30 Asp Asn Arg Arg
Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 35 40 45 Pro Ser
Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 50 55 60
Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 65
70 75 80 His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys
Asp Ser 85 90 95 Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe
Cys Thr Glu Leu 100 105 110 Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys
Val Met Gln Glu Glu Arg 115 120 125 Val Gly Glu Thr Pro Leu Met Asn
Ala Asp Ser Ile Leu Ala Val Lys 130 135 140 Lys Tyr Phe Arg Arg Ile
Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 145 150 155 160 Pro Cys Ala
Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 165 170 175 Leu
Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 180 185 <210>
SEQ ID NO 32 <211> LENGTH: 187 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 Met Thr
Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 1 5 10 15
Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 20
25 30 Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly
Arg 35 40 45 Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile
Pro Glu Glu 50 55 60 Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp
Ala Ala Leu Thr Ile 65 70 75 80 Tyr Glu Met Leu Gln Asn Ile Phe Ala
Ile Phe Arg Gln Asp Ser Ser 85 90 95 Ser Thr Gly Trp Asn Glu Thr
Ile Val Glu Asn Leu Leu Ala Asn Val 100 105 110 Tyr His Gln Ile Asn
His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 115 120 125 Lys Glu Asp
Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 130 135 140 Arg
Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 145 150
155 160 His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe
Tyr 165 170 175 Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 180 185
<210> SEQ ID NO 33 <211> LENGTH: 166 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 Met
Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 1 5 10
15 Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu
20 25 30 Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala
Asp Asn 35 40 45 Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys
Glu Glu Ser Asp 50 55 60 Arg Lys Ile Met Gln Ser Gln Ile Val Ser
Phe Tyr Phe Lys Leu Phe 65 70 75 80 Lys Asn Phe Lys Asp Asp Gln Ser
Ile Gln Lys Ser Val Glu Thr Ile 85 90 95 Lys Glu Asp Met Asn Val
Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 100 105 110 Asp Asp Phe Glu
Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 115 120 125 Gln Arg
Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 130 135 140
Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 145
150 155 160 Gly Arg Arg Ala Ser Gln 165 <210> SEQ ID NO 34
<211> LENGTH: 554 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 34 Met Thr Ala Pro Gly Ala Ala
Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu Leu Leu
Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30 Glu Glu Val
Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35 40 45 Gln
Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 50 55
60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys
65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu
Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala
Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys
Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala Cys Val Arg
Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu Lys Val Lys
Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160 Asp Lys Asp
Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165 170 175 Glu
Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 180 185
190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His
195 200 205 Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr
Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro
Gly Glu Gln Pro 225 230 235 240 Leu His Thr Val Asp Pro Gly Ser Ala
Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr Cys Gln Ser Phe Glu Pro
Pro Glu Thr Pro Val Val Lys Asp Ser 260 265 270 Thr Ile Gly Gly Ser
Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 275 280 285 Pro Gly Met
Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 290 295 300 Pro
Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 305 310
315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr
Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro
Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr
Gly Thr Ala Leu Pro 355 360 365 Arg Val Gly Pro Val Arg Pro Thr Gly
Gln Asp Trp Asn His Thr Pro 370 375 380 Gln Lys Thr Asp His Pro Ser
Ala Leu Leu Arg Asp Pro Pro Glu Pro 385 390 395 400 Gly Ser Pro Arg
Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 405 410 415 Ser Thr
Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 420 425 430
Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 435
440 445 Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly
Ala 450 455 460 Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr
Asp Thr Gly 465 470 475 480 His Glu Arg Gln Ser Glu Gly Ser Ser Ser
Pro Gln Leu Gln Glu Ser 485 490 495 Val Phe His Leu Leu Val Pro Ser
Val Ile Leu Val Leu Leu Ala Val 500 505 510 Gly Gly Leu Leu Phe Tyr
Arg Trp Arg Arg Arg Ser His Gln Glu Pro 515 520 525 Gln Arg Ala Asp
Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 530 535 540 Gln Asp
Asp Arg Gln Val Glu Leu Pro Val 545 550 <210> SEQ ID NO 35
<211> LENGTH: 554 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 35 Met Thr Ala Pro Gly Ala Ala
Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu Leu Leu
Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30 Glu Glu Val
Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35 40 45 Gln
Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 50 55
60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys
65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu
Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala
Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys
Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala Cys Val Arg
Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu Lys Val Lys
Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160 Asp Lys Asp
Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165 170 175 Glu
Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 180 185
190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His
195 200 205 Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr
Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro
Gly Glu Gln Pro 225 230 235 240 Leu His Thr Val Asp Pro Gly Ser Ala
Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr Cys Gln Ser Phe Glu Pro
Pro Glu Thr Pro Val Val Lys Asp Ser 260 265 270 Thr Ile Gly Gly Ser
Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 275 280 285 Pro Gly Met
Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 290 295 300 Pro
Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 305 310
315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr
Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro
Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr
Gly Thr Ala Leu Pro 355 360 365 Arg Val Gly Pro Val Arg Pro Thr Gly
Gln Asp Trp Asn His Thr Pro 370 375 380 Gln Lys Thr Asp His Pro Ser
Ala Leu Leu Arg Asp Pro Pro Glu Pro 385 390 395 400 Gly Ser Pro Arg
Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 405 410 415 Ser Thr
Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 420 425 430
Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 435
440 445 Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly
Ala 450 455 460 Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr
Asp Thr Gly 465 470 475 480 His Glu Arg Gln Ser Glu Gly Ser Ser Ser
Pro Gln Leu Gln Glu Ser 485 490 495 Val Phe His Leu Leu Val Pro Ser
Val Ile Leu Val Leu Leu Ala Val 500 505 510 Gly Gly Leu Leu Phe Tyr
Arg Trp Arg Arg Arg Ser His Gln Glu Pro 515 520 525 Gln Arg Ala Asp
Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 530 535 540 Gln Asp
Asp Arg Gln Val Glu Leu Pro Val 545 550 <210> SEQ ID NO 36
<211> LENGTH: 438 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 36 Met Thr Ala Pro Gly Ala Ala
Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu Leu Leu
Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30 Glu Glu Val
Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35 40 45 Gln
Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 50 55
60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys
65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu
Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala
Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys
Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala Cys Val Arg
Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu Lys Val Lys
Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160 Asp Lys Asp
Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165 170 175 Glu
Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 180 185
190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His
195 200 205 Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr
Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro
Gly Glu Gln Pro 225 230 235 240 Leu His Thr Val Asp Pro Gly Ser Ala
Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr Cys Gln Ser Phe Glu Pro
Pro Glu Thr Pro Val Val Lys Asp Ser 260 265 270 Thr Ile Gly Gly Ser
Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 275 280 285 Pro Gly Met
Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 290 295 300 Pro
Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 305 310
315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr
Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro
Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr
Gly His Glu Arg Gln 355 360 365 Ser Glu Gly Ser Ser Ser Pro Gln Leu
Gln Glu Ser Val Phe His Leu 370 375 380 Leu Val Pro Ser Val Ile Leu
Val Leu Leu Ala Val Gly Gly Leu Leu 385 390 395 400 Phe Tyr Arg Trp
Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 405 410 415 Ser Pro
Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 420 425 430
Gln Val Glu Leu Pro Val 435 <210> SEQ ID NO 37 <211>
LENGTH: 256 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 37 Met Thr Ala Pro Gly Ala Ala Gly
Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu Leu Leu Leu
Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30 Glu Glu Val Ser
Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35 40 45 Gln Ser
Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 50 55 60
Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 65
70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu
Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala
Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys
Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala Cys Val Arg
Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu Lys Val Lys
Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160 Asp Lys Asp
Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165 170 175 Glu
Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser 180 185
190 Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile
195 200 205 Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp
Arg Arg 210 215 220 Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro
Leu Glu Gln Pro 225 230 235 240 Glu Gly Ser Pro Leu Thr Gln Asp Asp
Arg Gln Val Glu Leu Pro Val 245 250 255 <210> SEQ ID NO 38
<211> LENGTH: 144 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 38 Met Trp Leu Gln Ser Leu Leu
Leu Leu Gly Thr Val Ala Cys Ser Ile 1 5 10 15 Ser Ala Pro Ala Arg
Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 20 25 30 Val Asn Ala
Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 35 40 45 Thr
Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 50 55
60 Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys
65 70 75 80 Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu
Thr Met 85 90 95 Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr
Pro Glu Thr Ser 100 105 110 Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser
Phe Lys Glu Asn Leu Lys 115 120 125 Asp Phe Leu Leu Val Ile Pro Phe
Asp Cys Trp Glu Pro Val Gln Glu 130 135 140 <210> SEQ ID NO
39 <211> LENGTH: 207 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 39 Met Ala Gly Pro Ala
Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 1 5 10 15 Leu Leu Leu
Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 20 25 30 Leu
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 35 40
45 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys
50 55 60 Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu
Glu Leu 65 70 75 80 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala
Pro Leu Ser Ser 85 90 95 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly
Cys Leu Ser Gln Leu His 100 105 110 Ser Gly Leu Phe Leu Tyr Gln Gly
Leu Leu Gln Ala Leu Glu Gly Ile 115 120 125 Ser Pro Glu Leu Gly Pro
Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 130 135 140 Asp Phe Ala Thr
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 145 150 155 160 Pro
Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 165 170
175 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser
180 185 190 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln
Pro 195 200 205 <210> SEQ ID NO 40 <211> LENGTH: 204
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 40 Met Ala Gly Pro Ala Thr Gln Ser Pro Met
Lys Leu Met Ala Leu Gln 1 5 10 15 Leu Leu Leu Trp His Ser Ala Leu
Trp Thr Val Gln Glu Ala Thr Pro 20 25 30 Leu Gly Pro Ala Ser Ser
Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 35 40 45 Glu Gln Val Arg
Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 50 55 60 Leu Cys
Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 65 70 75 80
Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 85
90 95 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly
Leu 100 105 110 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile
Ser Pro Glu 115 120 125 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp
Val Ala Asp Phe Ala 130 135 140 Thr Thr Ile Trp Gln Gln Met Glu Glu
Leu Gly Met Ala Pro Ala Leu 145 150 155 160 Gln Pro Thr Gln Gly Ala
Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 165 170 175 Arg Ala Gly Gly
Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 180 185 190 Val Ser
Tyr Arg Val Leu Arg His Leu Ala Gln Pro 195 200 <210> SEQ ID
NO 41 <211> LENGTH: 200 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 41 Met Ser Pro Glu Pro
Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 1 5 10 15 His Ser Ala
Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly Pro Ala 20 25 30 Ser
Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 35 40
45 Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr
50 55 60 Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His
Ser Leu 65 70 75 80 Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser
Gln Ala Leu Gln 85 90 95 Leu Ala Gly Cys Leu Ser Gln Leu His Ser
Gly Leu Phe Leu Tyr Gln 100 105 110 Gly Leu Leu Gln Ala Leu Glu Gly
Ile Ser Pro Glu Leu Gly Pro Thr 115 120 125 Leu Asp Thr Leu Gln Leu
Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 130 135 140 Gln Gln Met Glu
Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 145 150 155 160 Gly
Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170
175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg
180 185 190 Val Leu Arg His Leu Ala Gln Pro 195 200 <210> SEQ
ID NO 42 <211> LENGTH: 393 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 42 Met Glu Glu Pro Gln
Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe
Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser
Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40
45 Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
50 55 60 Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala
Ala Pro 65 70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro
Leu Ser Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser
Tyr Gly Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys
Ser Val Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe
Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp
Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala
Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170
175 Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
180 185 190 His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu
Asp Asp 195 200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr
Glu Pro Pro Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr
Asn Tyr Met Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn
Arg Arg Pro Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser
Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys
Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu
Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295
300 Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305 310 315 320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg
Gly Arg Glu 325 330 335 Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala
Leu Glu Leu Lys Asp 340 345 350 Ala Gln Ala Gly Lys Glu Pro Gly Gly
Ser Arg Ala His Ser Ser His 355 360 365 Leu Lys Ser Lys Lys Gly Gln
Ser Thr Ser Arg His Lys Lys Leu Met 370 375 380 Phe Lys Thr Glu Gly
Pro Asp Ser Asp 385 390 <210> SEQ ID NO 43 <211>
LENGTH: 393 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 43 Met Glu Glu Pro Gln Ser Asp Pro
Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe Ser Asp Leu
Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser Pro Leu Pro
Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40 45 Asp Ile
Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 50 55 60
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 65
70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser
Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly
Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys Ser Val
Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe Cys Gln
Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp Ser Thr
Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala Ile Tyr
Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170 175 Pro
His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 180 185
190 His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
195 200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro
Pro Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr
Met Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn Arg Arg
Pro Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser Gly Asn
Leu Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys Ala Cys
Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu Arg Lys
Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295 300 Lys
Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 305 310
315 320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg
Glu 325 330 335 Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu
Leu Lys Asp 340 345 350 Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg
Ala His Ser Ser His 355 360 365 Leu Lys Ser Lys Lys Gly Gln Ser Thr
Ser Arg His Lys Lys Leu Met 370 375 380 Phe Lys Thr Glu Gly Pro Asp
Ser Asp 385 390 <210> SEQ ID NO 44 <211> LENGTH: 341
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 44 Met Glu Glu Pro Gln Ser Asp Pro Ser Val
Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe Ser Asp Leu Trp Lys
Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser Pro Leu Pro Ser Gln
Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40 45 Asp Ile Glu Gln
Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 50 55 60 Arg Met
Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 65 70 75 80
Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 85
90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu
Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr
Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys
Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp Ser Thr Pro Pro Pro
Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala Ile Tyr Lys Gln Ser
Gln His Met Thr Glu Val Val Arg Arg Cys 165 170 175 Pro His His Glu
Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 180 185 190 His Leu
Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 195 200 205
Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 210
215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn
Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu
Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly
Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys Ala Cys Pro Gly Arg
Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu Arg Lys Lys Gly Glu
Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295 300 Lys Arg Ala Leu
Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 305 310 315 320 Lys
Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 325 330
335 Gln Lys Glu Asn Cys 340 <210> SEQ ID NO 45 <211>
LENGTH: 346 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 45 Met Glu Glu Pro Gln Ser Asp Pro
Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe Ser Asp Leu
Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser Pro Leu Pro
Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40 45 Asp Ile
Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 50 55 60
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 65
70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser
Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly
Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys Ser Val
Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe Cys Gln
Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp Ser Thr
Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala Ile Tyr
Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170 175 Pro
His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 180 185
190 His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
195 200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro
Pro Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr
Met Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn Arg Arg
Pro Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser Gly Asn
Leu Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys Ala Cys
Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu Arg Lys
Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295 300 Lys
Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 305 310
315 320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp
Leu 325 330 335 Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 340 345
<210> SEQ ID NO 46 <211> LENGTH: 261 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 Met
Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 1 5 10
15 Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys
20 25 30 Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His
His Glu 35 40 45 Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
His Leu Ile Arg 50 55 60 Val Glu Gly Asn Leu Arg Val Glu Tyr Leu
Asp Asp Arg Asn Thr Phe 65 70 75 80 Arg His Ser Val Val Val Pro Tyr
Glu Pro Pro Glu Val Gly Ser Asp 85 90 95 Cys Thr Thr Ile His Tyr
Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 100 105 110 Gly Met Asn Arg
Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 115 120 125 Ser Gly
Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 130 135 140
Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 145
150 155 160 Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg
Ala Leu 165 170 175 Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
Lys Pro Leu Asp 180 185 190 Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly
Arg Glu Arg Phe Glu Met 195 200 205 Phe Arg Glu Leu Asn Glu Ala Leu
Glu Leu Lys Asp Ala Gln Ala Gly 210 215 220 Lys Glu Pro Gly Gly Ser
Arg Ala His Ser Ser His Leu Lys Ser Lys 225 230 235 240 Lys Gly Gln
Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 245 250 255 Gly
Pro Asp Ser Asp 260 <210> SEQ ID NO 47 <211> LENGTH:
209 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 47 Met Phe Cys Gln Leu Ala Lys Thr Cys Pro
Val Gln Leu Trp Val Asp 1 5 10 15 Ser Thr Pro Pro Pro Gly Thr Arg
Val Arg Ala Met Ala Ile Tyr Lys 20 25 30 Gln Ser Gln His Met Thr
Glu Val Val Arg Arg Cys Pro His His Glu 35 40 45 Arg Cys Ser Asp
Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 50 55 60 Val Glu
Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 65 70 75 80
Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 85
90 95 Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met
Gly 100 105 110 Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu
Glu Asp Ser 115 120 125 Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu
Val Arg Val Cys Ala 130 135 140 Cys Pro Gly Arg Asp Arg Arg Thr Glu
Glu Glu Asn Leu Arg Lys Lys 145 150 155 160 Gly Glu Pro His His Glu
Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 165 170 175 Pro Asn Asn Thr
Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 180 185 190 Gly Glu
Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 195 200 205
Cys <210> SEQ ID NO 48 <211> LENGTH: 214 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
48 Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp
1 5 10 15 Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile
Tyr Lys 20 25 30 Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
Pro His His Glu 35 40 45 Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro
Pro Gln His Leu Ile Arg 50 55 60 Val Glu Gly Asn Leu Arg Val Glu
Tyr Leu Asp Asp Arg Asn Thr Phe 65 70 75 80 Arg His Ser Val Val Val
Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 85 90 95 Cys Thr Thr Ile
His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 100 105 110 Gly Met
Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 115 120 125
Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 130
135 140 Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys
Lys 145 150 155 160 Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
Lys Arg Ala Leu 165 170 175 Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro
Lys Lys Lys Pro Leu Asp 180 185 190 Gly Glu Tyr Phe Thr Leu Gln Met
Leu Leu Asp Leu Arg Trp Cys Tyr 195 200 205 Phe Leu Ile Asn Ser Ser
210 <210> SEQ ID NO 49 <211> LENGTH: 1237 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
49 Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu
1 5 10 15 Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile
Ser Asp 20 25 30 Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg
Asn Glu Pro Thr 35 40 45 Gln Gln Gln Arg Ala Ala Met Leu Ile Lys
Met Ile Leu Lys Lys Asp 50 55 60 Asn Asp Ser Tyr Val Ser Phe Tyr
Asn Ala Leu Leu His Glu Gly Tyr 65 70 75 80 Lys Asp Leu Ala Ala Leu
Leu His Asp Gly Ile Pro Val Val Ser Ser 85 90 95 Ser Ser Val Arg
Thr Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro 100 105 110 Val Val
Phe Val Thr Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys 115 120 125
Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val Thr Ile His Gly Met 130
135 140 Ala Gly Cys Gly Lys Ser Val Leu Ala Ala Glu Ala Val Arg Asp
His 145 150 155 160 Ser Leu Leu Glu Gly Cys Phe Pro Gly Gly Val His
Trp Val Ser Val 165 170 175 Gly Lys Gln Asp Lys Ser Gly Leu Leu Met
Lys Leu Gln Asn Leu Cys 180 185 190 Thr Arg Leu Asp Gln Asp Glu Ser
Phe Ser Gln Arg Leu Pro Leu Asn 195 200 205 Ile Glu Glu Ala Lys Asp
Arg Leu Arg Ile Leu Met Leu Arg Lys His 210 215 220 Pro Arg Ser Leu
Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu 225 230 235 240 Lys
Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Thr Thr Arg Asp Lys 245 250
255 Ser Val Thr Asp Ser Val Met Gly Pro Lys Tyr Val Val Pro Val Glu
260 265 270 Ser Ser Leu Gly Lys Glu Lys Gly Leu Glu Ile Leu Ser Leu
Phe Val 275 280 285 Asn Met Lys Lys Ala Asp Leu Pro Glu Gln Ala His
Ser Ile Ile Lys 290 295 300 Glu Cys Lys Gly Ser Pro Leu Val Val Ser
Leu Ile Gly Ala Leu Leu 305 310 315 320 Arg Asp Phe Pro Asn Arg Trp
Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 325 330 335 Lys Gln Phe Lys Arg
Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala 340 345 350 Leu Asp Glu
Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile 355 360 365 Lys
Asp Tyr Tyr Thr Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val 370 375
380 Pro Thr Lys Val Leu Cys Ile Leu Trp Asp Met Glu Thr Glu Glu Val
385 390 395 400 Glu Asp Ile Leu Gln Glu Phe Val Asn Lys Ser Leu Leu
Phe Cys Asp 405 410 415 Arg Asn Gly Lys Ser Phe Arg Tyr Tyr Leu His
Asp Leu Gln Val Asp 420 425 430 Phe Leu Thr Glu Lys Asn Cys Ser Gln
Leu Gln Asp Leu His Lys Lys 435 440 445 Ile Ile Thr Gln Phe Gln Arg
Tyr His Gln Pro His Thr Leu Ser Pro 450 455 460 Asp Gln Glu Asp Cys
Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met 465 470 475 480 Ala Ser
Ala Lys Met His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu 485 490 495
Asp Trp Ile Lys Ala Lys Thr Glu Leu Val Gly Pro Ala His Leu Ile 500
505 510 His Glu Phe Val Glu Tyr Arg His Ile Leu Asp Glu Lys Asp Cys
Ala 515 520 525 Val Ser Glu Asn Phe Gln Glu Phe Leu Ser Leu Asn Gly
His Leu Leu 530 535 540 Gly Arg Gln Pro Phe Pro Asn Ile Val Gln Leu
Gly Leu Cys Glu Pro 545 550 555 560 Glu Thr Ser Glu Val Tyr Gln Gln
Ala Lys Leu Gln Ala Lys Gln Glu 565 570 575 Val Asp Asn Gly Met Leu
Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 580 585 590 Thr Asn Leu Ser
Arg Leu Val Val Arg Pro His Thr Asp Ala Val Tyr 595 600 605 His Ala
Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala 610 615 620
Asp Lys Thr Leu Gln Val Phe Lys Ala Glu Thr Gly Glu Lys Leu Leu 625
630 635 640 Glu Ile Lys Ala His Glu Asp Glu Val Leu Cys Cys Ala Phe
Ser Thr 645 650 655 Asp Asp Arg Phe Ile Ala Thr Cys Ser Val Asp Lys
Lys Val Lys Ile 660 665 670 Trp Asn Ser Met Thr Gly Glu Leu Val His
Thr Tyr Asp Glu His Ser 675 680 685 Glu Gln Val Asn Cys Cys His Phe
Thr Asn Ser Ser His His Leu Leu 690 695 700 Leu Ala Thr Gly Ser Ser
Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 705 710 715 720 Gln Lys Glu
Cys Arg Asn Thr Met Phe Gly His Thr Asn Ser Val Asn 725 730 735 His
Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala 740 745
750 Asp Gly Thr Leu Lys Leu Trp Asp Ala Thr Ser Ala Asn Glu Arg Lys
755 760 765 Ser Ile Asn Val Lys Gln Phe Phe Leu Asn Leu Glu Asp Pro
Gln Glu 770 775 780 Asp Met Glu Val Ile Val Lys Cys Cys Ser Trp Ser
Ala Asp Gly Ala 785 790 795 800 Arg Ile Met Val Ala Ala Lys Asn Lys
Ile Phe Leu Phe Asp Ile His 805 810 815 Thr Ser Gly Leu Leu Gly Glu
Ile His Thr Gly His His Ser Thr Ile 820 825 830 Gln Tyr Cys Asp Phe
Ser Pro Gln Asn His Leu Ala Val Val Ala Leu 835 840 845 Ser Gln Tyr
Cys Val Glu Leu Trp Asn Thr Asp Ser Arg Ser Lys Val 850 855 860 Ala
Asp Cys Arg Gly His Leu Ser Trp Val His Gly Val Met Phe Ser 865 870
875 880 Pro Asp Gly Ser Ser Phe Leu Thr Ser Ser Asp Asp Gln Thr Ile
Arg 885 890 895 Leu Trp Glu Thr Lys Lys Val Cys Lys Asn Ser Ala Val
Met Leu Lys 900 905 910 Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu
Val Met Val Leu Ala 915 920 925 Val Asp His Ile Arg Arg Leu Gln Leu
Ile Asn Gly Arg Thr Gly Gln 930 935 940 Ile Asp Tyr Leu Thr Glu Ala
Gln Val Ser Cys Cys Cys Leu Ser Pro 945 950 955 960 His Leu Gln Tyr
Ile Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile 965 970 975 Leu Glu
Leu Val Asn Asn Arg Ile Phe Gln Ser Arg Phe Gln His Lys 980 985 990
Lys Thr Val Trp His Ile Gln Phe Thr Ala Asp Glu Lys Thr Leu Ile 995
1000 1005 Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp Asn Trp Gln
Leu Asp 1010 1015 1020 Lys Cys Ile Phe Leu Arg Gly His Gln Glu Thr
Val Lys Asp Phe Arg 1025 1030 1035 1040 Leu Leu Lys Asn Ser Arg Leu
Leu Ser Trp Ser Phe Asp Gly Thr Val 1045 1050 1055 Lys Val Trp Asn
Ile Ile Thr Gly Asn Lys Glu Lys Asp Phe Val Cys 1060 1065 1070 His
Gln Gly Thr Val Leu Ser Cys Asp Ile Ser His Asp Ala Thr Lys 1075
1080 1085 Phe Ser Ser Thr Ser Ala Asp Lys Thr Ala Lys Ile Trp Ser
Phe Asp 1090 1095 1100 Leu Leu Leu Pro Leu His Glu Leu Arg Gly His
Asn Gly Cys Val Arg 1105 1110 1115 1120 Cys Ser Ala Phe Ser Val Asp
Ser Thr Leu Leu Ala Thr Gly Asp Asp 1125 1130 1135 Asn Gly Glu Ile
Arg Ile Trp Asn Val Ser Asn Gly Glu Leu Leu His 1140 1145 1150 Leu
Cys Ala Pro Leu Ser Glu Glu Gly Ala Ala Thr His Gly Gly Trp 1155
1160 1165 Val Thr Asp Leu Cys Phe Ser Pro Asp Gly Lys Met Leu Ile
Ser Ala 1170 1175 1180 Gly Gly Tyr Ile Lys Trp Trp Asn Val Val Thr
Gly Glu Ser Ser Gln 1185 1190 1195 1200 Thr Phe Tyr Thr Asn Gly Thr
Asn Leu Lys Lys Ile His Val Ser Pro 1205 1210 1215 Asp Phe Lys Thr
Tyr Val Thr Val Asp Asn Leu Gly Ile Leu Tyr Ile 1220 1225 1230 Leu
Gln Thr Leu Glu 1235 <210> SEQ ID NO 50 <211> LENGTH:
1194 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 50 Met Asp Ala Lys Ala Arg Asn Cys Leu Leu
Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp Ile Lys Thr Ser Tyr
Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly Phe Leu Thr Ile Ser
Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40 45 Gln Gln Gln Arg
Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 50 55 60 Asn Asp
Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 65 70 75 80
Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 85
90 95 Ser Ser Val Arg Thr Val Leu Cys Glu Gly Gly Val Pro Gln Arg
Pro 100 105 110 Val Val Phe Val Thr Arg Lys Lys Leu Val Asn Ala Ile
Gln Gln Lys 115 120 125 Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val
Thr Ile His Gly Met 130 135 140 Ala Gly Cys Gly Lys Ser Val Leu Ala
Ala Glu Ala Val Arg Asp His 145 150 155 160 Ser Leu Leu Glu Gly Cys
Phe Pro Gly Gly Val His Trp Val Ser Val 165 170 175 Gly Lys Gln Asp
Lys Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys 180 185 190 Thr Arg
Leu Asp Gln Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn 195 200 205
Ile Glu Glu Ala Lys Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His 210
215 220 Pro Arg Ser Leu Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val
Leu 225 230 235 240 Lys Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Thr
Thr Arg Asp Lys 245 250 255 Ser Val Thr Asp Ser Val Met Gly Pro Lys
Tyr Val Val Pro Val Glu 260 265 270 Ser Ser Leu Gly Lys Glu Lys Gly
Leu Glu Ile Leu Ser Leu Phe Val 275 280 285 Asn Met Lys Lys Ala Asp
Leu Pro Glu Gln Ala His Ser Ile Ile Lys 290 295 300 Glu Cys Lys Gly
Ser Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu 305 310 315 320 Arg
Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 325 330
335 Lys Gln Phe Lys Arg Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala
340 345 350 Leu Asp Glu Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu
Asp Ile 355 360 365 Lys Asp Tyr Tyr Thr Asp Leu Ser Ile Leu Gln Lys
Asp Val Lys Val 370 375 380 Pro Thr Lys Val Leu Cys Ile Leu Trp Asp
Met Glu Thr Glu Glu Val 385 390 395 400 Glu Asp Ile Leu Gln Glu Phe
Val Asn Lys Ser Leu Leu Phe Cys Asp 405 410 415 Arg Asn Gly Lys Ser
Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp 420 425 430 Phe Leu Thr
Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys 435 440 445 Ile
Ile Thr Gln Phe Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro 450 455
460 Asp Gln Glu Asp Cys Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met
465 470 475 480 Ala Ser Ala Lys Met His Lys Glu Leu Cys Ala Leu Met
Phe Ser Leu 485 490 495 Asp Trp Ile Lys Ala Lys Thr Glu Leu Val Gly
Pro Ala His Leu Ile 500 505 510 His Glu Phe Val Glu Tyr Arg His Ile
Leu Asp Glu Lys Asp Cys Ala 515 520 525 Val Ser Glu Asn Phe Gln Glu
Phe Leu Ser Leu Asn Gly His Leu Leu 530 535 540 Gly Arg Gln Pro Phe
Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro 545 550 555 560 Glu Thr
Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu 565 570 575
Val Asp Asn Gly Met Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 580
585 590 Thr Asn Leu Ser Arg Leu Val Val Arg Pro His Thr Asp Ala Val
Tyr 595 600 605 His Ala Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser
Cys Gly Ala 610 615 620 Asp Lys Thr Leu Gln Val Phe Lys Ala Glu Thr
Gly Glu Lys Leu Leu 625 630 635 640 Glu Ile Lys Ala His Glu Asp Glu
Val Leu Cys Cys Ala Phe Ser Thr 645 650 655 Asp Asp Arg Phe Ile Ala
Thr Cys Ser Val Asp Lys Lys Val Lys Ile 660 665 670 Trp Asn Ser Met
Thr Gly Glu Leu Val His Thr Tyr Asp Glu His Ser 675 680 685 Glu Gln
Val Asn Cys Cys His Phe Thr Asn Ser Ser His His Leu Leu 690 695 700
Leu Ala Thr Gly Ser Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 705
710 715 720 Gln Lys Glu Cys Arg Asn Thr Met Phe Gly His Thr Asn Ser
Val Asn 725 730 735 His Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala
Ser Cys Ser Ala 740 745 750 Asp Gly Thr Leu Lys Leu Trp Asp Ala Thr
Ser Ala Asn Glu Arg Lys 755 760 765 Ser Ile Asn Val Lys Gln Phe Phe
Leu Asn Leu Glu Asp Pro Gln Glu 770 775 780 Asp Met Glu Val Ile Val
Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala 785 790 795 800 Arg Ile Met
Val Ala Ala Lys Asn Lys Ile Phe Leu Trp Asn Thr Asp 805 810 815 Ser
Arg Ser Lys Val Ala Asp Cys Arg Gly His Leu Ser Trp Val His 820 825
830 Gly Val Met Phe Ser Pro Asp Gly Ser Ser Phe Leu Thr Ser Ser Asp
835 840 845 Asp Gln Thr Ile Arg Leu Trp Glu Thr Lys Lys Val Cys Lys
Asn Ser 850 855 860 Ala Val Met Leu Lys Gln Glu Val Asp Val Val Phe
Gln Glu Asn Glu 865 870 875 880 Val Met Val Leu Ala Val Asp His Ile
Arg Arg Leu Gln Leu Ile Asn 885 890 895 Gly Arg Thr Gly Gln Ile Asp
Tyr Leu Thr Glu Ala Gln Val Ser Cys 900 905 910 Cys Cys Leu Ser Pro
His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn 915 920 925 Gly Ala Ile
Glu Ile Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser 930 935 940 Arg
Phe Gln His Lys Lys Thr Val Trp His Ile Gln Phe Thr Ala Asp 945 950
955 960 Glu Lys Thr Leu Ile Ser Ser Ser Asp Asp Ala Glu Ile Gln Val
Trp 965 970 975 Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu Arg Gly His
Gln Glu Thr 980 985 990 Val Lys Asp Phe Arg Leu Leu Lys Asn Ser Arg
Leu Leu Ser Trp Ser 995 1000 1005 Phe Asp Gly Thr Val Lys Val Trp
Asn Ile Ile Thr Gly Asn Lys Glu 1010 1015 1020 Lys Asp Phe Val Cys
His Gln Gly Thr Val Leu Ser Cys Asp Ile Ser 1025 1030 1035 1040 His
Asp Ala Thr Lys Phe Ser Ser Thr Ser Ala Asp Lys Thr Ala Lys 1045
1050 1055 Ile Trp Ser Phe Asp Leu Leu Leu Pro Leu His Glu Leu Arg
Gly His 1060 1065 1070 Asn Gly Cys Val Arg Cys Ser Ala Phe Ser Val
Asp Ser Thr Leu Leu 1075 1080 1085 Ala Thr Gly Asp Asp Asn Gly Glu
Ile Arg Ile Trp Asn Val Ser Asn 1090 1095 1100 Gly Glu Leu Leu His
Leu Cys Ala Pro Leu Ser Glu Glu Gly Ala Ala 1105 1110 1115 1120 Thr
His Gly Gly Trp Val Thr Asp Leu Cys Phe Ser Pro Asp Gly Lys 1125
1130 1135 Met Leu Ile Ser Ala Gly Gly Tyr Ile Lys Trp Trp Asn Val
Val Thr 1140 1145 1150 Gly Glu Ser Ser Gln Thr Phe Tyr Thr Asn Gly
Thr Asn Leu Lys Lys 1155 1160 1165 Ile His Val Ser Pro Asp Phe Lys
Thr Tyr Val Thr Val Asp Asn Leu 1170 1175 1180 Gly Ile Leu Tyr Ile
Leu Gln Thr Leu Glu 1185 1190 <210> SEQ ID NO 51 <211>
LENGTH: 1248 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 51 Met Asp Ala Lys Ala Arg Asn Cys
Leu Leu Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp Ile Lys Thr
Ser Tyr Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly Phe Leu Thr
Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40 45 Gln Gln
Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 50 55 60
Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 65
70 75 80 Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val
Ser Ser 85 90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser
Tyr Val Arg Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro Gln Arg
Pro Val Val Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn Ala Ile
Gln Gln Lys Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly Trp Val
Thr Ile His Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser Val Leu
Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170 175 Cys
Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 180 185
190 Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu Asp Gln
195 200 205 Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu
Ala Lys 210 215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro
Arg Ser Leu Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp Ser Trp
Val Leu Lys Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu Leu Thr
Thr Arg Asp Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly Pro Lys
Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu Lys Gly
Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295 300 Asp
Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser 305 310
315 320 Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp Phe Pro
Asn 325 330 335 Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn Lys Gln
Phe Lys Arg 340 345 350 Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala
Leu Asp Glu Ala Met 355 360 365 Ser Ile Ser Val Glu Met Leu Arg Glu
Asp Ile Lys Asp Tyr Tyr Thr 370 375 380 Asp Leu Ser Ile Leu Gln Lys
Asp Val Lys Val Pro Thr Lys Val Leu 385 390 395 400 Cys Ile Leu Trp
Asp Met Glu Thr Glu Glu Val Glu Asp Ile Leu Gln 405 410 415 Glu Phe
Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 420 425 430
Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Thr Glu Lys 435
440 445 Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile Thr Gln
Phe 450 455 460 Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro Asp Gln
Glu Asp Cys 465 470 475 480 Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His
Met Ala Ser Ala Lys Met 485 490 495 His Lys Glu Leu Cys Ala Leu Met
Phe Ser Leu Asp Trp Ile Lys Ala 500 505 510 Lys Thr Glu Leu Val Gly
Pro Ala His Leu Ile His Glu Phe Val Glu 515 520 525 Tyr Arg His Ile
Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 530 535 540 Gln Glu
Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 545 550 555
560 Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Thr Ser Glu Val
565 570 575 Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val Asp Asn
Gly Met 580 585 590 Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile Thr
Asn Leu Ser Arg 595 600 605 Leu Val Val Arg Pro His Thr Asp Ala Val
Tyr His Ala Cys Phe Ser 610 615 620 Glu Asp Gly Gln Arg Ile Ala Ser
Cys Gly Ala Asp Lys Thr Leu Gln 625 630 635 640 Val Phe Lys Ala Glu
Thr Gly Glu Lys Leu Leu Glu Ile Lys Ala His 645 650 655 Glu Asp Glu
Val Leu Cys Cys Ala Phe Ser Thr Asp Asp Arg Phe Ile 660 665 670 Ala
Thr Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Thr 675 680
685 Gly Glu Leu Val His Thr Tyr Asp Glu His Ser Glu Gln Val Asn Cys
690 695 700 Cys His Phe Thr Asn Ser Ser His His Leu Leu Leu Ala Thr
Gly Ser 705 710 715 720 Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn
Gln Lys Glu Cys Arg 725 730 735 Asn Thr Met Phe Gly His Thr Asn Ser
Val Asn His Cys Arg Phe Ser 740 745 750 Pro Asp Asp Lys Leu Leu Ala
Ser Cys Ser Ala Asp Gly Thr Leu Lys 755 760 765 Leu Trp Asp Ala Thr
Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 770 775 780 Gln Phe Phe
Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 785 790 795 800
Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val Ala 805
810 815 Ala Lys Asn Lys Ile Phe Leu Phe Asp Ile His Thr Ser Gly Leu
Leu 820 825 830 Gly Glu Ile His Thr Gly His His Ser Thr Ile Gln Tyr
Cys Asp Phe 835 840 845 Ser Pro Gln Asn His Leu Ala Val Val Ala Leu
Ser Gln Tyr Cys Val 850 855 860 Glu Leu Trp Asn Thr Asp Ser Arg Ser
Lys Val Ala Asp Cys Arg Gly 865 870 875 880 His Leu Ser Trp Val His
Gly Val Met Phe Ser Pro Asp Gly Ser Ser 885 890 895 Phe Leu Thr Ser
Ser Asp Asp Gln Thr Ile Arg Leu Trp Glu Thr Lys 900 905 910 Lys Val
Cys Lys Asn Ser Ala Val Met Leu Lys Gln Glu Val Asp Val 915 920 925
Val Phe Gln Glu Asn Glu Val Met Val Leu Ala Val Asp His Ile Arg 930
935 940 Arg Leu Gln Leu Ile Asn Gly Arg Thr Gly Gln Ile Asp Tyr Leu
Thr 945 950 955 960 Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro His
Leu Gln Tyr Ile 965 970 975 Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu
Ile Leu Glu Leu Val Asn 980 985 990 Asn Arg Ile Phe Gln Ser Arg Phe
Gln His Lys Lys Thr Val Trp His 995 1000 1005 Ile Gln Phe Thr Ala
Asp Glu Lys Thr Leu Ile Ser Ser Ser Asp Asp 1010 1015 1020 Ala Glu
Ile Gln Val Trp Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu 1025 1030
1035 1040 Arg Gly His Gln Glu Thr Val Lys Asp Phe Arg Leu Leu Lys
Asn Ser 1045 1050 1055 Arg Leu Leu Ser Trp Ser Phe Asp Gly Thr Val
Lys Val Trp Asn Ile 1060 1065 1070 Ile Thr Gly Asn Lys Glu Lys Asp
Phe Val Cys His Gln Gly Thr Val 1075 1080 1085 Leu Ser Cys Asp Ile
Ser His Asp Ala Thr Lys Phe Ser Ser Thr Ser 1090 1095 1100 Ala Asp
Lys Thr Ala Lys Ile Trp Ser Phe Asp Leu Leu Leu Pro Leu 1105 1110
1115 1120 His Glu Leu Arg Gly His Asn Gly Cys Val Arg Cys Ser Ala
Phe Ser 1125 1130 1135 Val Asp Ser Thr Leu Leu Ala Thr Gly Asp Asp
Asn Gly Glu Ile Arg 1140 1145 1150 Ile Trp Asn Val Ser Asn Gly Glu
Leu Leu His Leu Cys Ala Pro Leu 1155 1160 1165 Ser Glu Glu Gly Ala
Ala Thr His Gly Gly Trp Val Thr Asp Leu Cys 1170 1175 1180 Phe Ser
Pro Asp Gly Lys Met Leu Ile Ser Ala Gly Gly Tyr Ile Lys 1185 1190
1195 1200 Trp Trp Asn Val Val Thr Gly Glu Ser Ser Gln Thr Phe Tyr
Thr Asn 1205 1210 1215 Gly Thr Asn Leu Lys Lys Ile His Val Ser Pro
Asp Phe Lys Thr Tyr 1220 1225 1230 Val Thr Val Asp Asn Leu Gly Ile
Leu Tyr Ile Leu Gln Thr Leu Glu 1235 1240 1245 <210> SEQ ID
NO 52 <211> LENGTH: 1205 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 52 Met Asp Ala Lys Ala
Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp
Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly
Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40
45 Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp
50 55 60 Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu
Gly Tyr 65 70 75 80 Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro
Val Val Ser Ser 85 90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile
Thr Ser Tyr Val Arg Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro
Gln Arg Pro Val Val Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn
Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly
Trp Val Thr Ile His Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser
Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170
175 Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys
180 185 190 Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu
Asp Gln 195 200 205 Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile
Glu Glu Ala Lys 210 215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys
His Pro Arg Ser Leu Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp
Ser Trp Val Leu Lys Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu
Leu Thr Thr Arg Asp Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly
Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu
Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295
300 Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser
305 310 315 320 Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp
Phe Pro Asn 325 330 335 Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn
Lys Gln Phe Lys Arg 340 345 350 Ile Arg Lys Ser Ser Ser Tyr Asp Tyr
Glu Ala Leu Asp Glu Ala Met 355 360 365 Ser Ile Ser Val Glu Met Leu
Arg Glu Asp Ile Lys Asp Tyr Tyr Thr 370 375 380 Asp Leu Ser Ile Leu
Gln Lys Asp Val Lys Val Pro Thr Lys Val Leu 385 390 395 400 Cys Ile
Leu Trp Asp Met Glu Thr Glu Glu Val Glu Asp Ile Leu Gln 405 410 415
Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 420
425 430 Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Thr Glu
Lys 435 440 445 Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile
Thr Gln Phe 450 455 460 Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro
Asp Gln Glu Asp Cys 465 470 475 480 Met Tyr Trp Tyr Asn Phe Leu Ala
Tyr His Met Ala Ser Ala Lys Met 485 490 495 His Lys Glu Leu Cys Ala
Leu Met Phe Ser Leu Asp Trp Ile Lys Ala 500 505 510 Lys Thr Glu Leu
Val Gly Pro Ala His Leu Ile His Glu Phe Val Glu 515 520 525 Tyr Arg
His Ile Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 530 535 540
Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 545
550 555 560 Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Thr Ser
Glu Val 565 570 575 Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val
Asp Asn Gly Met 580 585 590 Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn
Ile Thr Asn Leu Ser Arg 595 600 605 Leu Val Val Arg Pro His Thr Asp
Ala Val Tyr His Ala Cys Phe Ser 610 615 620 Glu Asp Gly Gln Arg Ile
Ala Ser Cys Gly Ala Asp Lys Thr Leu Gln 625 630 635 640 Val Phe Lys
Ala Glu Thr Gly Glu Lys Leu Leu Glu Ile Lys Ala His 645 650 655 Glu
Asp Glu Val Leu Cys Cys Ala Phe Ser Thr Asp Asp Arg Phe Ile 660 665
670 Ala Thr Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Thr
675 680 685 Gly Glu Leu Val His Thr Tyr Asp Glu His Ser Glu Gln Val
Asn Cys 690 695 700 Cys His Phe Thr Asn Ser Ser His His Leu Leu Leu
Ala Thr Gly Ser 705 710 715 720 Ser Asp Cys Phe Leu Lys Leu Trp Asp
Leu Asn Gln Lys Glu Cys Arg 725 730 735 Asn Thr Met Phe Gly His Thr
Asn Ser Val Asn His Cys Arg Phe Ser 740 745 750 Pro Asp Asp Lys Leu
Leu Ala Ser Cys Ser Ala Asp Gly Thr Leu Lys 755 760 765 Leu Trp Asp
Ala Thr Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 770 775 780 Gln
Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 785 790
795 800 Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val
Ala 805 810 815 Ala Lys Asn Lys Ile Phe Leu Trp Asn Thr Asp Ser Arg
Ser Lys Val 820 825 830 Ala Asp Cys Arg Gly His Leu Ser Trp Val His
Gly Val Met Phe Ser 835 840 845 Pro Asp Gly Ser Ser Phe Leu Thr Ser
Ser Asp Asp Gln Thr Ile Arg 850 855 860 Leu Trp Glu Thr Lys Lys Val
Cys Lys Asn Ser Ala Val Met Leu Lys 865 870 875 880 Gln Glu Val Asp
Val Val Phe Gln Glu Asn Glu Val Met Val Leu Ala 885 890 895 Val Asp
His Ile Arg Arg Leu Gln Leu Ile Asn Gly Arg Thr Gly Gln 900 905 910
Ile Asp Tyr Leu Thr Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro 915
920 925 His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu
Ile 930 935 940 Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser Arg Phe
Gln His Lys 945 950 955 960 Lys Thr Val Trp His Ile Gln Phe Thr Ala
Asp Glu Lys Thr Leu Ile 965 970 975 Ser Ser Ser Asp Asp Ala Glu Ile
Gln Val Trp Asn Trp Gln Leu Asp 980 985 990 Lys Cys Ile Phe Leu Arg
Gly His Gln Glu Thr Val Lys Asp Phe Arg 995 1000 1005 Leu Leu Lys
Asn Ser Arg Leu Leu Ser Trp Ser Phe Asp Gly Thr Val 1010 1015 1020
Lys Val Trp Asn Ile Ile Thr Gly Asn Lys Glu Lys Asp Phe Val Cys
1025 1030 1035 1040 His Gln Gly Thr Val Leu Ser Cys Asp Ile Ser His
Asp Ala Thr Lys 1045 1050 1055 Phe Ser Ser Thr Ser Ala Asp Lys Thr
Ala Lys Ile Trp Ser Phe Asp 1060 1065 1070 Leu Leu Leu Pro Leu His
Glu Leu Arg Gly His Asn Gly Cys Val Arg 1075 1080 1085 Cys Ser Ala
Phe Ser Val Asp Ser Thr Leu Leu Ala Thr Gly Asp Asp 1090 1095 1100
Asn Gly Glu Ile Arg Ile Trp Asn Val Ser Asn Gly Glu Leu Leu His
1105 1110 1115 1120 Leu Cys Ala Pro Leu Ser Glu Glu Gly Ala Ala Thr
His Gly Gly Trp 1125 1130 1135 Val Thr Asp Leu Cys Phe Ser Pro Asp
Gly Lys Met Leu Ile Ser Ala 1140 1145 1150 Gly Gly Tyr Ile Lys Trp
Trp Asn Val Val Thr Gly Glu Ser Ser Gln 1155 1160 1165 Thr Phe Tyr
Thr Asn Gly Thr Asn Leu Lys Lys Ile His Val Ser Pro 1170 1175 1180
Asp Phe Lys Thr Tyr Val Thr Val Asp Asn Leu Gly Ile Leu Tyr Ile
1185 1190 1195 1200 Leu Gln Thr Leu Glu 1205 <210> SEQ ID NO
53 <211> LENGTH: 338 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 53 Met Asp Ala Lys Ala
Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp
Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly
Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40
45 Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp
50 55 60 Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu
Gly Tyr 65 70 75 80 Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro
Val Val Ser Ser 85 90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile
Thr Ser Tyr Val Arg Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro
Gln Arg Pro Val Val Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn
Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly
Trp Val Thr Ile His Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser
Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170
175 Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys
180 185 190 Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu
Asp Gln 195 200 205 Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile
Glu Glu Ala Lys 210 215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys
His Pro Arg Ser Leu Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp
Ser Trp Val Leu Lys Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu
Leu Thr Thr Arg Asp Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly
Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu
Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295
300 Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Val Val
305 310 315 320 Glu Arg Cys His Trp Gly Ile Leu Thr Asp Leu Leu His
Lys Trp Asn 325 330 335 Gln Ser <210> SEQ ID NO 54
<211> LENGTH: 281 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 54 Met Ala Met Met Glu Val Gln
Gly Gly Pro Ser Leu Gly Gln Thr Cys 1 5 10 15 Val Leu Ile Val Ile
Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 20 25 30 Val Thr Tyr
Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 35 40 45 Tyr
Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 50 55
60 Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val
65 70 75 80 Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg
Thr Ser 85 90 95 Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln
Asn Ile Ser Pro 100 105 110 Leu Val Arg Glu Arg Gly Pro Gln Arg Val
Ala Ala His Ile Thr Gly 115 120 125 Thr Arg Gly Arg Ser Asn Thr Leu
Ser Ser Pro Asn Ser Lys Asn Glu 130 135 140 Lys Ala Leu Gly Arg Lys
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 145 150 155 160 His Ser Phe
Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 165 170 175 His
Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 180 185
190 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln
195 200 205 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu
Met Lys 210 215 220 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu
Tyr Gly Leu Tyr 225 230 235 240 Ser Ile Tyr Gln Gly Gly Ile Phe Glu
Leu Lys Glu Asn Asp Arg Ile 245 250 255 Phe Val Ser Val Thr Asn Glu
His Leu Ile Asp Met Asp His Glu Ala 260 265 270 Ser Phe Phe Gly Ala
Phe Leu Val Gly 275 280 <210> SEQ ID NO 55 <211>
LENGTH: 277 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 55 Met Glu Asn Thr Glu Asn Ser Val
Asp Ser Lys Ser Ile Lys Asn Leu 1 5 10 15 Glu Pro Lys Ile Ile His
Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 20 25 30 Leu Asp Asn Ser
Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 35 40 45 Ile Ile
Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 50 55 60
Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 65
70 75 80 Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu
Glu Ile 85 90 95 Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His
Ser Lys Arg Ser 100 105 110 Ser Phe Val Cys Val Leu Leu Ser His Gly
Glu Glu Gly Ile Ile Phe 115 120 125 Gly Thr Asn Gly Pro Val Asp Leu
Lys Lys Ile Thr Asn Phe Phe Arg 130 135 140 Gly Asp Arg Cys Arg Ser
Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 145 150 155 160 Gln Ala Cys
Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 165 170 175 Gly
Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 180 185
190 Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn
195 200 205 Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met
Leu Lys 210 215 220 Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu
Thr Arg Val Asn 225 230 235 240 Arg Lys Val Ala Thr Glu Phe Glu Ser
Phe Ser Phe Asp Ala Thr Phe 245 250 255 His Ala Lys Lys Gln Ile Pro
Cys Ile Val Ser Met Leu Thr Lys Glu 260 265 270 Leu Tyr Phe Tyr His
275 <210> SEQ ID NO 56 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
56 Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser
1 5 10 15 Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe
Ile Gln 20 25 30 Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu
Leu Ala Leu Asp 35 40 45 Pro Val Pro Gln Asp Ala Ser Thr Lys Lys
Leu Ser Glu Cys Leu Lys 50 55 60 Arg Ile Gly Asp Glu Leu Asp Ser
Asn Met Glu Leu Gln Arg Met Ile 65 70 75 80 Ala Ala Val Asp Thr Asp
Ser Pro Arg Glu Val Phe Phe Arg Val Ala 85 90 95 Ala Asp Met Phe
Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 100 105 110 Leu Phe
Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 115 120 125
Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 130
135 140 Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp
Gly 145 150 155 160 Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr
Val Thr Ile Phe 165 170 175 Val Ala Gly Val Leu Thr Ala Ser Leu Thr
Ile Trp Lys Lys Met Gly 180 185 190 <210> SEQ ID NO 57
<211> LENGTH: 168 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 57 Met Phe Gln Ile Pro Glu Phe
Glu Pro Ser Glu Gln Glu Asp Ser Ser 1 5 10 15 Ser Ala Glu Arg Gly
Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 20 25 30 Gly Ser Gly
Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 35 40 45 Ser
His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 50 55
60 Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr
65 70 75 80 Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg
Gly Arg 85 90 95 Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln
Arg Tyr Gly Arg 100 105 110 Glu Leu Arg Arg Met Ser Asp Glu Phe Val
Asp Ser Phe Lys Lys Gly 115 120 125 Leu Pro Arg Pro Lys Ser Ala Gly
Thr Ala Thr Gln Met Arg Gln Ser 130 135 140 Ser Ser Trp Thr Arg Val
Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 145 150 155 160 Arg Gly Ser
Ser Ala Pro Ser Gln 165 <210> SEQ ID NO 58 <211>
LENGTH: 208 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 58 Met Asp Pro Phe Leu Val Leu Leu
His Ser Val Ser Ser Ser Leu Ser 1 5 10 15 Ser Ser Glu Leu Thr Glu
Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 20 25 30 Lys Arg Lys Leu
Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 35 40 45 Leu Leu
Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 50 55 60
Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 65
70 75 80 Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu
Glu Asp 85 90 95 Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val
Gly Lys Asp Trp 100 105 110 Arg Arg Leu Ala Arg Gln Leu Lys Val Ser
Asp Thr Lys Ile Asp Ser 115 120 125 Ile Glu Asp Arg Tyr Pro Arg Asn
Leu Thr Glu Arg Val Arg Glu Ser 130 135 140 Leu Arg Ile Trp Lys Asn
Thr Glu Lys Glu Asn Ala Thr Val Ala His 145 150 155 160 Leu Val Gly
Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 165 170 175 Val
Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 180 185
190 Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser
195 200 205 <210> SEQ ID NO 59 <211> LENGTH: 384
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 59 Met Ser Arg Ser Lys Arg Asp Asn Asn Phe
Tyr Ser Val Glu Ile Gly 1 5 10 15 Asp Ser Thr Phe Thr Val Leu Lys
Arg Tyr Gln Asn Leu Lys Pro Ile 20 25 30 Gly Ser Gly Ala Gln Gly
Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 35 40 45 Glu Arg Asn Val
Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 50 55 60 Thr His
Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 65 70 75 80
Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 85
90 95 Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met
Asp 100 105 110 Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His
Glu Arg Met 115 120 125 Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile
Lys His Leu His Ser 130 135 140 Ala Gly Ile Ile His Arg Asp Leu Lys
Pro Ser Asn Ile Val Val Lys 145 150 155 160 Ser Asp Cys Thr Leu Lys
Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 165 170 175 Gly Thr Ser Phe
Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 180 185 190 Ala Pro
Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 195 200 205
Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 210
215 220 Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu
Gln 225 230 235 240 Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu
Gln Pro Thr Val 245 250 255 Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr
Ala Gly Tyr Ser Phe Glu 260 265 270 Lys Leu Phe Pro Asp Val Leu Phe
Pro Ala Asp Ser Glu His Asn Lys 275 280 285 Leu Lys Ala Ser Gln Ala
Arg Asp Leu Leu Ser Lys Met Leu Val Ile 290 295 300 Asp Ala Ser Lys
Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 305 310 315 320 Ile
Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 325 330
335 Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp
340 345 350 Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg
Thr Lys 355 360 365 Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala
Gln Val Gln Gln 370 375 380 <210> SEQ ID NO 60 <211>
LENGTH: 427 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 60 Met Ser Arg Ser Lys Arg Asp Asn
Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10 15 Asp Ser Thr Phe Thr Val
Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 20 25 30 Gly Ser Gly Ala
Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 35 40 45 Glu Arg
Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 50 55 60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 65
70 75 80 Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro
Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met
Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys Gln Val Ile Gln Met Glu
Leu Asp His Glu Arg Met 115 120 125 Ser Tyr Leu Leu Tyr Gln Met Leu
Cys Gly Ile Lys His Leu His Ser 130 135 140 Ala Gly Ile Ile His Arg
Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145 150 155 160 Ser Asp Cys
Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 165 170 175 Gly
Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 180 185
190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu
195 200 205 Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys
Ile Leu 210 215 220 Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys
Val Ile Glu Gln 225 230 235 240 Leu Gly Thr Pro Cys Pro Glu Phe Met
Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg Thr Tyr Val Glu Asn Arg
Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265 270 Lys Leu Phe Pro Asp
Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 275 280 285 Leu Lys Ala
Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 290 295 300 Asp
Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 305 310
315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro
Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile
Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu
Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val Ile Arg Gly Gln Pro Ser
Pro Leu Gly Ala Ala Val Ile 370 375 380 Asn Gly Ser Gln His Pro Ser
Ser Ser Ser Ser Val Asn Asp Val Ser 385 390 395 400 Ser Met Ser Thr
Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 405 410 415 Glu Ala
Ala Ala Gly Pro Leu Gly Cys Cys Arg 420 425 <210> SEQ ID NO
61 <211> LENGTH: 384 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 61 Met Ser Arg Ser Lys
Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10 15 Asp Ser Thr
Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 20 25 30 Gly
Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 35 40
45 Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln
50 55 60 Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys
Cys Val 65 70 75 80 Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe
Thr Pro Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile
Val Met Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys Gln Val Ile Gln
Met Glu Leu Asp His Glu Arg Met 115 120 125 Ser Tyr Leu Leu Tyr Gln
Met Leu Cys Gly Ile Lys His Leu His Ser 130 135 140 Ala Gly Ile Ile
His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145 150 155 160 Ser
Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 165 170
175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg
180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val
Asp Ile 195 200 205 Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys
Gly Gly Val Leu 210 215 220 Phe Pro Gly Thr Asp His Ile Asp Gln Trp
Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly Thr Pro Cys Pro Glu
Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg Thr Tyr Val Glu
Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265 270 Lys Leu Phe
Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 275 280 285 Leu
Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 290 295
300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr
305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro
Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His
Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr Lys Glu Val Met
Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val Ile Arg Gly Gln
Pro Ser Pro Leu Ala Gln Val Gln Gln 370 375 380 <210> SEQ ID
NO 62 <211> LENGTH: 427 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 62 Met Ser Arg Ser Lys
Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10 15 Asp Ser Thr
Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 20 25 30 Gly
Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 35 40
45 Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln
50 55 60 Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys
Cys Val 65 70 75 80 Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe
Thr Pro Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile
Val Met Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys Gln Val Ile Gln
Met Glu Leu Asp His Glu Arg Met 115 120 125 Ser Tyr Leu Leu Tyr Gln
Met Leu Cys Gly Ile Lys His Leu His Ser 130 135 140 Ala Gly Ile Ile
His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145 150 155 160 Ser
Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 165 170
175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg
180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val
Asp Ile 195 200 205 Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys
Gly Gly Val Leu 210 215 220 Phe Pro Gly Thr Asp His Ile Asp Gln Trp
Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly Thr Pro Cys Pro Glu
Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg Thr Tyr Val Glu
Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265 270 Lys Leu Phe
Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 275 280 285 Leu
Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 290 295
300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr
305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro
Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His
Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr Lys Glu Val Met
Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val Ile Arg Gly Gln
Pro Ser Pro Leu Gly Ala Ala Val Ile 370 375 380 Asn Gly Ser Gln His
Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 385 390 395 400 Ser Met
Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 405 410 415
Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 420 425 <210> SEQ
ID NO 63 <211> LENGTH: 360 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 63 Met Ser Gln Glu Arg
Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 1 5 10 15 Ile Trp Glu
Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 20 25 30 Gly
Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 35 40
45 Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His
50 55 60 Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met
Lys His 65 70 75 80 Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro
Ala Arg Ser Leu 85 90 95 Glu Glu Phe Asn Asp Val Tyr Leu Val Thr
His Leu Met Gly Ala Asp 100 105 110 Leu Asn Asn Ile Val Lys Cys Gln
Lys Leu Thr Asp Asp His Val Gln 115 120 125 Phe Leu Ile Tyr Gln Ile
Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 130 135 140 Asp Ile Ile His
Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 145 150 155 160 Asp
Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 165 170
175 Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu
180 185 190 Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile
Trp Ser 195 200 205 Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg
Thr Leu Phe Pro 210 215 220 Gly Thr Asp His Ile Asn Gln Leu Gln Gln
Ile Met Arg Leu Thr Gly 225 230 235 240 Thr Pro Pro Ala Tyr Leu Ile
Asn Arg Met Pro Ser His Glu Ala Arg 245 250 255 Asn Tyr Ile Gln Ser
Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 260 265 270 Val Phe Ile
Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 275 280 285 Leu
Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 290 295
300 His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala
305 310 315 320 Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu
Ile Asp Glu 325 330 335 Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser
Phe Val Pro Pro Pro 340 345 350 Leu Asp Gln Glu Glu Met Glu Ser 355
360 <210> SEQ ID NO 64 <211> LENGTH: 240 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
64 Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly
1 5 10 15 Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val
Ala Met 20 25 30 Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val
Pro Ser Thr Ala 35 40 45 Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu
Arg His Pro Asn Ile Val 50 55 60 Ser Leu Gln Asp Val Leu Met Gln
Asp Ser Arg Leu Tyr Leu Ile Phe 65 70 75 80 Glu Phe Leu Ser Met Asp
Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 85 90 95 Gly Gln Tyr Met
Asp Ser Ser Leu Val Lys Val Val Thr Leu Trp Tyr 100 105 110 Arg Ser
Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser Thr Pro Val 115 120 125
Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu Leu Ala Thr Lys Lys 130
135 140 Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile
Phe 145 150 155 160 Arg Ala Leu Gly Thr Pro Asn Asn Glu Val Trp Pro
Glu Val Glu Ser 165 170 175 Leu Gln Asp Tyr Lys Asn Thr Phe Pro Lys
Trp Lys Pro Gly Ser Leu 180 185 190 Ala Ser His Val Lys Asn Leu Asp
Glu Asn Gly Leu Asp Leu Leu Ser 195 200 205 Lys Met Leu Ile Tyr Asp
Pro Ala Lys Arg Ile Ser Gly Lys Met Ala 210 215 220 Leu Asn His Pro
Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys Met 225 230 235 240
<210> SEQ ID NO 65 <211> LENGTH: 432 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 65 Met
Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 1 5 10
15 Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn
20 25 30 Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr
Arg Ala 35 40 45 Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly
Leu Ala Gln Gln 50 55 60 Gln Arg Pro Lys Thr Arg Arg Val Ala Pro
Leu Lys Asp Leu Pro Val 65 70 75 80 Asn Asp Glu His Val Thr Val Pro
Pro Trp Lys Ala Asn Ser Lys Gln 85 90 95 Pro Ala Phe Thr Ile His
Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 100 105 110 Lys Pro Ala Glu
Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 115 120 125 Asn Ser
Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 130 135 140
Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 145
150 155 160 Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu
Val Pro 165 170 175 Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu
Met Glu Val Lys 180 185 190 Cys Lys Pro Lys Val Gly Tyr Met Lys Lys
Gln Pro Asp Ile Thr Asn 195 200 205 Ser Met Arg Ala Ile Leu Val Asp
Trp Leu Val Glu Val Gly Glu Glu 210 215 220 Tyr Lys Leu Gln Asn Glu
Thr Leu His Leu Ala Val Asn Tyr Ile Asp 225 230 235 240 Arg Phe Leu
Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 245 250 255 Gly
Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 260 265
270 Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys
275 280 285 Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu
Thr Phe 290 295 300 Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr
Gln Tyr Phe Leu 305 310 315 320 His Gln Gln Pro Ala Asn Cys Lys Val
Glu Ser Leu Ala Met Phe Leu 325 330 335 Gly Glu Leu Ser Leu Ile Asp
Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 340 345 350 Ser Val Ile Ala Gly
Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 355 360 365 Gly Gln Ser
Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 370 375 380 Glu
Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 385 390
395 400 Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn
Ser 405 410 415 Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr
Leu Asn Leu 420 425 430 <210> SEQ ID NO 66 <211>
LENGTH: 289 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 66 Met Glu Leu Leu Cys His Glu Val
Asp Pro Val Arg Arg Ala Val Arg 1 5 10 15 Asp Arg Asn Leu Leu Arg
Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 20 25 30 Ile Glu Glu Arg
Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 35 40 45 Lys Asp
Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu 50 55 60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala 65
70 75 80 Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro
Lys Ser 85 90 95 His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu
Ala Ser Lys Leu 100 105 110 Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys
Leu Cys Ile Tyr Thr Asp 115 120 125 Asn Ser Ile Lys Pro Gln Glu Leu
Leu Glu Trp Glu Leu Val Val Leu 130 135 140 Gly Lys Leu Lys Trp Asn
Leu Ala Ala Val Thr Pro His Asp Phe Ile 145 150 155 160 Glu His Ile
Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 165 170 175 Ile
Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe 180 185
190 Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
195 200 205 Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser
Leu Thr 210 215 220 Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr
Asn Thr Asp Val 225 230 235 240 Asp Cys Leu Lys Ala Cys Gln Glu Gln
Ile Glu Ala Val Leu Leu Asn 245 250 255 Ser Leu Gln Gln Tyr Arg Gln
Asp Gln Arg Asp Gly Ser Lys Ser Glu 260 265 270 Asp Glu Leu Asp Gln
Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 275 280 285 Leu
<210> SEQ ID NO 67 <211> LENGTH: 292 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 67 Met
Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 1 5 10
15 Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu
20 25 30 Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln
Cys Val 35 40 45 Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu
Ala Tyr Trp Met 50 55 60 Leu Glu Val Cys Glu Glu Gln Arg Cys Glu
Glu Glu Val Phe Pro Leu 65 70 75 80 Ala Met Asn Tyr Leu Asp Arg Tyr
Leu Ser Cys Val Pro Thr Arg Lys 85 90 95 Ala Gln Leu Gln Leu Leu
Gly Ala Val Cys Met Leu Leu Ala Ser Lys 100 105 110 Leu Arg Glu Thr
Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 115 120 125 Asp His
Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 130 135 140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 145
150 155 160 Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg
Gln Ala 165 170 175 Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu
Cys Ala Thr Asp 180 185 190 Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met
Ile Ala Thr Gly Ser Ile 195 200 205 Gly Ala Ala Val Gln Gly Leu Gly
Ala Cys Ser Met Ser Gly Asp Glu 210 215 220 Leu Thr Glu Leu Leu Ala
Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 225 230 235 240 Arg Ala Cys
Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 245 250 255 Glu
Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 260 265
270 Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr
275 280 285 Ala Ile His Leu 290 <210> SEQ ID NO 68
<211> LENGTH: 410 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 68 Met Pro Arg Glu Arg Arg Glu
Arg Asp Ala Lys Glu Arg Asp Thr Met 1 5 10 15 Lys Glu Asp Gly Gly
Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 20 25 30 Ala Asn Val
Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 35 40 45 Ile
Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 50 55
60 Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys
65 70 75 80 Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro
Arg Ile 85 90 95 Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu
Ser Trp Ala Asn 100 105 110 Arg Glu Glu Val Trp Lys Ile Met Leu Asn
Lys Glu Lys Thr Tyr Leu 115 120 125 Arg Asp Gln His Phe Leu Glu Gln
His Pro Leu Leu Gln Pro Lys Met 130 135 140 Arg Ala Ile Leu Leu Asp
Trp Leu Met Glu Val Cys Glu Val Tyr Lys 145 150 155 160 Leu His Arg
Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 165 170 175 Met
Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 180 185
190 Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro
195 200 205 Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser
Gly Asp 210 215 220 Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala
Leu Lys Trp Arg 225 230 235 240 Leu Ser Pro Leu Thr Ile Val Ser Trp
Leu Asn Val Tyr Met Gln Val 245 250 255 Ala Tyr Leu Asn Asp Leu His
Glu Val Leu Leu Pro Gln Tyr Pro Gln 260 265 270 Gln Ile Phe Ile Gln
Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 275 280 285 Val Asp Cys
Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 290 295 300 Tyr
His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 305 310
315 320 Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala
Met 325 330 335 Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe
Arg Gly Val 340 345 350 Ala Asp Glu Asp Ala His Asn Ile Gln Thr His
Arg Asp Ser Leu Asp 355 360 365 Leu Leu Asp Lys Ala Arg Ala Lys Lys
Ala Met Leu Ser Glu Gln Asn 370 375 380 Arg Ala Ser Pro Leu Pro Ser
Gly Leu Leu Thr Pro Pro Gln Ser Gly 385 390 395 400 Lys Lys Gln Ser
Ser Gly Pro Glu Met Ala 405 410 <210> SEQ ID NO 69
<211> LENGTH: 473 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 69 Met Ser Thr Glu Leu Phe Ser
Ser Thr Arg Glu Glu Gly Ser Ser Gly 1 5 10 15 Ser Gly Pro Ser Phe
Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 20 25 30 Leu Glu Arg
Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 35 40 45 Pro
Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 50 55
60 Gly Gly Thr Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly
65 70 75 80 Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp
Glu Thr 85 90 95 Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His
Leu Ala Gly Met 100 105 110 Asn His Asp Gln His Leu Met Lys Cys Ser
Pro Ala Gln Leu Leu Cys 115 120 125 Ser Thr Pro Asn Gly Leu Asp Arg
Gly His Arg Lys Arg Asp Ala Met 130 135 140 Cys Ser Ser Ser Ala Asn
Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 145 150 155 160 Ser Glu Met
Lys Tyr Leu Gly Ser Pro Ile Thr Thr Val Pro Lys Leu 165 170 175 Asp
Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 180 185
190 Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg
195 200 205 Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn
Arg Pro 210 215 220 Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr
Ile Pro Asp Lys 225 230 235 240 Val Lys Lys Lys Tyr Phe Ser Gly Gln
Gly Lys Leu Arg Lys Gly Leu 245 250 255 Cys Leu Lys Lys Thr Val Ser
Leu Cys Asp Ile Thr Ile Thr Gln Met 260 265 270 Leu Glu Glu Asp Ser
Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 275 280 285 Val Cys Ala
Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 290 295 300 Val
Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 305 310
315 320 Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu
Tyr 325 330 335 Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser
Gln Glu Glu 340 345 350 Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val
Pro Leu Asp Thr Gln 355 360 365 Lys Arg Ile Ile Ile Val Phe His Cys
Glu Phe Ser Ser Glu Arg Gly 370 375 380 Pro Arg Met Cys Arg Cys Leu
Arg Glu Glu Asp Arg Ser Leu Asn Gln 385 390 395 400 Tyr Pro Ala Leu
Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 405 410 415 Arg Asp
Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 420 425 430
Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys Arg 435
440 445 Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln
Ile 450 455 460 Ala Leu Leu Val Lys Asp Met Ser Pro 465 470
<210> SEQ ID NO 70 <211> LENGTH: 400 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met
Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 1 5 10
15 Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu
20 25 30 Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro
Arg Thr 35 40 45 Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu
Ser Ile Leu Ser 50 55 60 Gly Ser Pro Gly Phe Phe Arg Thr Ser Gly
Ser Ala Phe Ser Trp Asp 65 70 75 80 Asp Asn Gly Asn Leu Val Asp Ser
Glu Met Lys Tyr Leu Gly Ser Pro 85 90 95 Ile Thr Thr Val Pro Lys
Leu Asp Lys Asn Pro Asn Leu Gly Glu Asp 100 105 110 Gln Ala Glu Glu
Ile Ser Asp Glu Leu Met Glu Phe Ser Leu Lys Asp 115 120 125 Gln Glu
Ala Lys Val Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met 130 135 140
Pro Glu Asn Leu Asn Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys 145
150 155 160 Asp Asn Thr Ile Pro Asp Lys Val Lys Lys Lys Tyr Phe Ser
Gly Gln 165 170 175 Gly Lys Leu Arg Lys Gly Leu Cys Leu Lys Lys Thr
Val Ser Leu Cys 180 185 190 Asp Ile Thr Ile Thr Gln Met Leu Glu Glu
Asp Ser Asn Gln Gly His 195 200 205 Leu Ile Gly Asp Phe Ser Lys Val
Cys Ala Leu Pro Thr Val Ser Gly 210 215 220 Lys His Gln Asp Leu Lys
Tyr Val Asn Pro Glu Thr Val Ala Ala Leu 225 230 235 240 Leu Ser Gly
Lys Phe Gln Gly Leu Ile Glu Lys Phe Tyr Val Ile Asp 245 250 255 Cys
Arg Tyr Pro Tyr Glu Tyr Leu Gly Gly His Ile Gln Gly Ala Leu 260 265
270 Asn Leu Tyr Ser Gln Glu Glu Leu Phe Asn Phe Phe Leu Lys Lys Pro
275 280 285 Ile Val Pro Leu Asp Thr Gln Lys Arg Ile Ile Ile Val Phe
His Cys 290 295 300 Glu Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg
Cys Leu Arg Glu 305 310 315 320 Glu Asp Arg Ser Leu Asn Gln Tyr Pro
Ala Leu Tyr Tyr Pro Glu Leu 325 330 335 Tyr Ile Leu Lys Gly Gly Tyr
Arg Asp Phe Phe Pro Glu Tyr Met Glu 340 345 350 Leu Cys Glu Pro Gln
Ser Tyr Cys Pro Met His His Gln Asp His Lys 355 360 365 Thr Glu Leu
Leu Arg Cys Arg Ser Gln Ser Lys Val Gln Glu Gly Glu 370 375 380 Arg
Gln Leu Arg Glu Gln Ile Ala Leu Leu Val Lys Asp Met Ser Pro 385 390
395 400 <210> SEQ ID NO 71 <211> LENGTH: 164
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 71 Met Ser Glu Pro Ala Gly Asp Val Arg Gln
Asn Pro Cys Gly Ser Lys 1 5 10 15 Ala Cys Arg Arg Leu Phe Gly Pro
Val Asp Ser Glu Gln Leu Ser Arg 20 25 30 Asp Cys Asp Ala Leu Met
Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 35 40 45 Trp Asn Phe Asp
Phe Val Thr Glu Thr Pro Leu Glu Gly Asp Phe Ala 50 55 60 Trp Glu
Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Thr 65 70 75 80
Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 85
90 95 Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His Val
Asp 100 105 110 Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu
Gln Ala Glu 115 120 125 Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly
Arg Lys Arg Arg Gln 130 135 140 Thr Ser Met Thr Asp Phe Tyr His Ser
Lys Arg Arg Leu Ile Phe Ser 145 150 155 160 Lys Arg Lys Pro
<210> SEQ ID NO 72 <211> LENGTH: 156 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met
Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 1 5 10
15 Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
20 25 30 Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg
Arg Pro 35 40 45 Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala
Glu Leu Leu Leu 50 55 60 Leu His Gly Ala Glu Pro Asn Cys Ala Asp
Pro Ala Thr Leu Thr Arg 65 70 75 80 Pro Val His Asp Ala Ala Arg Glu
Gly Phe Leu Asp Thr Leu Val Val 85 90 95 Leu His Arg Ala Gly Ala
Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 100 105 110 Leu Pro Val Asp
Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 115 120 125 Tyr Leu
Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 130 135 140
Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 145 150 155
<210> SEQ ID NO 73 <211> LENGTH: 116 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 73 Met
Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 1 5 10
15 Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
20 25 30 Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg
Arg Pro 35 40 45 Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly
Asp Gly Gly Arg 50 55 60 Leu Trp Arg Thr Lys Phe Ala Gly Glu Leu
Glu Ser Gly Ser Ala Ser 65 70 75 80 Ile Leu Arg Lys Lys Gly Arg Leu
Pro Gly Glu Phe Ser Glu Gly Val 85 90 95 Cys Asn His Arg Pro Pro
Pro Gly Asp Ala Leu Gly Ala Trp Glu Ala 100 105 110 Lys Glu Glu Glu
115 <210> SEQ ID NO 74 <211> LENGTH: 173 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
74 Met Gly Arg Gly Arg Cys Val Gly Pro Ser Leu Gln Leu Arg Gly Gln
1 5 10 15 Glu Trp Arg Cys Ser Pro Leu Val Pro Lys Gly Gly Ala Ala
Ala Ala 20 25 30 Glu Leu Gly Pro Gly Gly Gly Glu Asn Met Val Arg
Arg Phe Leu Val 35 40 45 Thr Leu Arg Ile Arg Arg Ala Cys Gly Pro
Pro Arg Val Arg Val Phe 50 55 60 Val Val His Ile Pro Arg Leu Thr
Gly Glu Trp Ala Ala Pro Gly Ala 65 70 75 80 Pro Ala Ala Val Ala Leu
Val Leu Met Leu Leu Arg Ser Gln Arg Leu 85 90 95 Gly Gln Gln Pro
Leu Pro Arg Arg Pro Gly His Asp Asp Gly Gln Arg 100 105 110 Pro Ser
Gly Gly Ala Ala Ala Ala Pro Arg Arg Gly Ala Gln Leu Arg 115 120 125
Arg Pro Arg His Ser His Pro Thr Arg Ala Arg Arg Cys Pro Gly Gly 130
135 140 Leu Pro Gly His Ala Gly Gly Ala Ala Pro Gly Arg Gly Ala Ala
Gly 145 150 155 160 Arg Ala Arg Cys Leu Gly Pro Ser Ala Arg Gly Pro
Gly 165 170 <210> SEQ ID NO 75 <211> LENGTH: 298
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 75 Met Glu Asn Phe Gln Lys Val Glu Lys Ile
Gly Glu Gly Thr Tyr Gly 1 5 10 15 Val Val Tyr Lys Ala Arg Asn Lys
Leu Thr Gly Glu Val Val Ala Leu 20 25 30 Lys Lys Ile Arg Leu Asp
Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 35 40 45 Ile Arg Glu Ile
Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 50 55 60 Lys Leu
Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 65 70 75 80
Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 85
90 95 Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu
Leu 100 105 110 Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His
Arg Asp Leu 115 120 125 Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly
Ala Ile Lys Leu Ala 130 135 140 Asp Phe Gly Leu Ala Arg Ala Phe Gly
Val Pro Val Arg Thr Tyr Thr 145 150 155 160 His Glu Val Val Thr Leu
Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 165 170 175 Cys Lys Tyr Tyr
Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 180 185 190 Phe Ala
Glu Met Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 195 200 205
Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 210
215 220 Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser
Phe 225 230 235 240 Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val
Pro Pro Leu Asp 245 250 255 Glu Asp Gly Arg Ser Leu Leu Ser Gln Met
Leu His Tyr Asp Pro Asn 260 265 270 Lys Arg Ile Ser Ala Lys Ala Ala
Leu Ala His Pro Phe Phe Gln Asp 275 280 285 Val Thr Lys Pro Val Pro
His Leu Arg Leu 290 295 <210> SEQ ID NO 76 <211>
LENGTH: 264 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 76 Met Glu Asn Phe Gln Lys Val Glu
Lys Ile Gly Glu Gly Thr Tyr Gly 1 5 10 15 Val Val Tyr Lys Ala Arg
Asn Lys Leu Thr Gly Glu Val Val Ala Leu 20 25 30 Lys Lys Ile Arg
Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 35 40 45 Ile Arg
Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 50 55 60
Lys Leu Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 65
70 75 80 Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser
Ala Leu 85 90 95 Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu
Phe Gln Leu Leu 100 105 110 Gln Gly Leu Ala Phe Cys His Ser His Arg
Val Leu His Arg Asp Leu 115 120 125 Lys Pro Gln Asn Leu Leu Ile Asn
Thr Glu Gly Ala Ile Lys Leu Ala 130 135 140 Asp Phe Gly Leu Ala Arg
Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 145 150 155 160 His Glu Val
Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu Ile Asp 165 170 175 Gln
Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu Val Val 180 185
190 Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe Pro Lys
195 200 205 Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp
Glu Asp 210 215 220 Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp
Pro Asn Lys Arg 225 230 235 240 Ile Ser Ala Lys Ala Ala Leu Ala His
Pro Phe Phe Gln Asp Val Thr 245 250 255 Lys Pro Val Pro His Leu Arg
Leu 260 <210> SEQ ID NO 77 <211> LENGTH: 303
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 77 Met Ala Thr Ser Arg Tyr Glu Pro Val Ala
Glu Ile Gly Val Gly Ala 1 5 10 15 Tyr Gly Thr Val Tyr Lys Ala Arg
Asp Pro His Ser Gly His Phe Val 20 25 30 Ala Leu Lys Ser Val Arg
Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 35 40 45 Leu Pro Ile Ser
Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 50 55 60 Ala Phe
Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 65 70 75 80
Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 85
90 95 Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly
Leu 100 105 110 Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu
Arg Gly Leu 115 120 125 Asp Phe Leu His Ala Asn Cys Ile Val His Arg
Asp Leu Lys Pro Glu 130 135 140 Asn Ile Leu Val Thr Ser Gly Gly Thr
Val Lys Leu Ala Asp Phe Gly 145 150 155 160 Leu Ala Arg Ile Tyr Ser
Tyr Gln Met Ala Leu Thr Pro Val Val Val 165 170 175 Thr Leu Trp Tyr
Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 180 185 190 Thr Pro
Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 195 200 205
Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 210
215 220 Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro
Arg 225 230 235 240 Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg
Gly Pro Arg Pro 245 250 255 Val Gln Ser Val Val Pro Glu Met Glu Glu
Ser Gly Ala Gln Leu Leu 260 265 270 Leu Glu Met Leu Thr Phe Asn Pro
His Lys Arg Ile Ser Ala Phe Arg 275 280 285 Ala Leu Gln His Ser Tyr
Leu His Lys Asp Glu Gly Asn Pro Glu 290 295 300 <210> SEQ ID
NO 78 <211> LENGTH: 326 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met Glu Lys Asp Gly
Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 1 5 10 15 Ala Glu Ile
Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 20 25 30 Leu
Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 35 40
45 Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val
50 55 60 Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg
Leu Phe 65 70 75 80 Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr
Lys Leu Thr Leu 85 90 95 Val Phe Glu His Val Asp Gln Asp Leu Thr
Thr Tyr Leu Asp Lys Val 100 105 110 Pro Glu Pro Gly Val Pro Thr Glu
Thr Ile Lys Asp Met Met Phe Gln 115 120 125 Leu Leu Arg Gly Leu Asp
Phe Leu His Ser His Arg Val Val His Arg 130 135 140 Asp Leu Lys Pro
Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 145 150 155 160 Leu
Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 165 170
175 Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu
180 185 190 Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly
Cys Ile 195 200 205 Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg
Gly Ser Ser Asp 210 215 220 Val Asp Gln Leu Gly Lys Ile Leu Asp Val
Ile Gly Leu Pro Gly Glu 225 230 235 240 Glu Asp Trp Pro Arg Asp Val
Ala Leu Pro Arg Gln Ala Phe His Ser 245 250 255 Lys Ser Ala Gln Pro
Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 260 265 270 Gly Lys Asp
Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 275 280 285 Ile
Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 290 295
300 Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr
305 310 315 320 Ser Glu Leu Asn Thr Ala 325 <210> SEQ ID NO
79 <211> LENGTH: 437 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 79 Met Ala Leu Ala Gly
Ala Pro Ala Gly Gly Pro Cys Ala Pro Ala Leu 1 5 10 15 Glu Ala Leu
Leu Gly Ala Gly Ala Leu Arg Leu Leu Asp Ser Ser Gln 20 25 30 Ile
Val Ile Ile Ser Ala Ala Gln Asp Ala Ser Ala Pro Pro Ala Pro 35 40
45 Thr Gly Pro Ala Ala Pro Ala Ala Gly Pro Cys Asp Pro Asp Leu Leu
50 55 60 Leu Phe Ala Thr Pro Gln Ala Pro Arg Pro Thr Pro Ser Ala
Pro Arg 65 70 75 80 Pro Ala Leu Gly Arg Pro Pro Val Lys Arg Arg Leu
Asp Leu Glu Thr 85 90 95 Asp His Gln Tyr Leu Ala Glu Ser Ser Gly
Pro Ala Arg Gly Arg Gly 100 105 110 Arg His Pro Gly Lys Gly Val Lys
Ser Pro Gly Glu Lys Ser Arg Tyr 115 120 125 Glu Thr Ser Leu Asn Leu
Thr Thr Lys Arg Phe Leu Glu Leu Leu Ser 130 135 140 His Ser Ala Asp
Gly Val Val Asp Leu Asn Trp Ala Ala Glu Val Leu 145 150 155 160 Lys
Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu Glu Gly 165 170
175 Ile Gln Leu Ile Ala Lys Lys Ser Lys Asn His Ile Gln Trp Leu Gly
180 185 190 Ser His Thr Thr Val Gly Val Gly Gly Arg Leu Glu Gly Leu
Thr Gln 195 200 205 Asp Leu Arg Gln Leu Gln Glu Ser Glu Gln Gln Leu
Asp His Leu Met 210 215 220 Asn Ile Cys Thr Thr Gln Leu Arg Leu Leu
Ser Glu Asp Thr Asp Ser 225 230 235 240 Gln Arg Leu Ala Tyr Val Thr
Cys Gln Asp Leu Arg Ser Ile Ala Asp 245 250 255 Pro Ala Glu Gln Met
Val Met Val Ile Lys Ala Pro Pro Glu Thr Gln 260 265 270 Leu Gln Ala
Val Asp Ser Ser Glu Asn Phe Gln Ile Ser Leu Lys Ser 275 280 285 Lys
Gln Gly Pro Ile Asp Val Phe Leu Cys Pro Glu Glu Thr Val Gly 290 295
300 Gly Ile Ser Pro Gly Lys Thr Pro Ser Gln Glu Val Thr Ser Glu Glu
305 310 315 320 Glu Asn Arg Ala Thr Asp Ser Ala Thr Ile Val Ser Pro
Pro Pro Ser 325 330 335 Ser Pro Pro Ser Ser Leu Thr Thr Asp Pro Ser
Gln Ser Leu Leu Ser 340 345 350 Leu Glu Gln Glu Pro Leu Leu Ser Arg
Met Gly Ser Leu Arg Ala Pro 355 360 365 Val Asp Glu Asp Arg Leu Ser
Pro Leu Val Ala Ala Asp Ser Leu Leu 370 375 380 Glu His Val Arg Glu
Asp Phe Ser Gly Leu Leu Pro Glu Glu Phe Ile 385 390 395 400 Ser Leu
Ser Pro Pro His Glu Ala Leu Asp Tyr His Phe Gly Leu Glu 405 410 415
Glu Gly Glu Gly Ile Arg Asp Leu Phe Asp Cys Asp Phe Gly Asp Leu 420
425 430 Thr Pro Leu Asp Phe 435 <210> SEQ ID NO 80
<211> LENGTH: 1170 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Gly Leu Ala Trp
Gly Leu Gly Val Leu Phe Leu Met His Val Cys 1 5 10 15 Gly Thr Asn
Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 20 25 30 Ile
Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 35 40
45 Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala
50 55 60 Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu
Val Asp 65 70 75 80 Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala
Ser Leu Arg Gln 85 90 95 Met Lys Lys Thr Arg Gly Thr Leu Leu Ala
Leu Glu Arg Lys Asp His 100 105 110 Ser Gly Gln Val Phe Ser Val Val
Ser Asn Gly Lys Ala Gly Thr Leu 115 120 125 Asp Leu Ser Leu Thr Val
Gln Gly Lys Gln His Val Val Ser Val Glu 130 135 140 Glu Ala Leu Leu
Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 145 150 155 160 Gln
Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 165 170
175 Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala
180 185 190 Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp
Asn Phe 195 200 205 Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly
Thr Thr Pro Glu 210 215 220 Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser
Ser Thr Ser Val Leu Leu 225 230 235 240 Thr Leu Asp Asn Asn Val Val
Asn Gly Ser Ser Pro Ala Ile Arg Thr 245 250 255 Asn Tyr Ile Gly His
Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 260 265 270 Ser Cys Asp
Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 275 280 285 Thr
Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 290 295
300 Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His
305 310 315 320 Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val
Asp Ser Cys 325 330 335 Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile
Cys Lys Lys Val Ser 340 345 350 Cys Pro Ile Met Pro Cys Ser Asn Ala
Thr Val Pro Asp Gly Glu Cys 355 360 365 Cys Pro Arg Cys Trp Pro Ser
Asp Ser Ala Asp Asp Gly Trp Ser Pro 370 375 380 Trp Ser Glu Trp Thr
Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 385 390 395 400 Gln Arg
Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 405 410 415
Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 420
425 430 Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys
Ser 435 440 445 Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu
Cys Asn Ser 450 455 460 Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu
Gly Glu Ala Arg Glu 465 470 475 480 Thr Lys Ala Cys Lys Lys Asp Ala
Cys Pro Ile Asn Gly Gly Trp Gly 485 490 495 Pro Trp Ser Pro Trp Asp
Ile Cys Ser Val Thr Cys Gly Gly Gly Val 500 505 510 Gln Lys Arg Ser
Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 515 520 525 Lys Asp
Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 530 535 540
Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 545
550 555 560 Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala
Cys Pro 565 570 575 Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp
Val Asp Glu Cys 580 585 590 Lys Glu Val Pro Asp Ala Cys Phe Asn His
Asn Gly Glu His Arg Cys 595 600 605 Glu Asn Thr Asp Pro Gly Tyr Asn
Cys Leu Pro Cys Pro Pro Arg Phe 610 615 620 Thr Gly Ser Gln Pro Phe
Gly Gln Gly Val Glu His Ala Thr Ala Asn 625 630 635 640 Lys Gln Val
Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 645 650 655 Cys
Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 660 665
670 Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile
675 680 685 Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn
Leu Val 690 695 700 Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp
Asn Cys Pro Asn 705 710 715 720 Leu Pro Asn Ser Gly Gln Glu Asp Tyr
Asp Lys Asp Gly Ile Gly Asp 725 730 735 Ala Cys Asp Asp Asp Asp Asp
Asn Asp Lys Ile Pro Asp Asp Arg Asp 740 745 750 Asn Cys Pro Phe His
Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 755 760 765 Asp Val Gly
Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 770 775 780 Gln
Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 785 790
795 800 Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr
Val 805 810 815 Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val
Gly Asp Gln 820 825 830 Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp
Gln Leu Asp Ser Asp 835 840 845 Ser Asp Arg Ile Gly Asp Thr Cys Asp
Asn Asn Gln Asp Ile Asp Glu 850 855 860 Asp Gly His Gln Asn Asn Leu
Asp Asn Cys Pro Tyr Val Pro Asn Ala 865 870 875 880 Asn Gln Ala Asp
His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 885 890 895 Asp Asp
Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 900 905 910
Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 915
920 925 Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp
Asp 930 935 940 Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe
Arg Arg Phe 945 950 955 960 Gln Met Ile Pro Leu Asp Pro Lys Gly Thr
Ser Gln Asn Asp Pro Asn 965 970 975 Trp Val Val Arg His Gln Gly Lys
Glu Leu Val Gln Thr Val Asn Cys 980 985 990 Asp Pro Gly Leu Ala Val
Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 995 1000 1005 Ser Gly Thr
Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 1010 1015 1020
Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp
1025 1030 1035 1040 Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro
Thr Arg Ala Gln 1045 1050 1055 Gly Tyr Ser Gly Leu Ser Val Lys Val
Val Asn Ser Thr Thr Gly Pro 1060 1065 1070 Gly Glu His Leu Arg Asn
Ala Leu Trp His Thr Gly Asn Thr Pro Gly 1075 1080 1085 Gln Val Arg
Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 1090 1095 1100
Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe
1105 1110 1115 1120 Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met
Ala Asp Ser Gly 1125 1130 1135 Pro Ile Tyr Asp Lys Thr Tyr Ala Gly
Gly Arg Leu Gly Leu Phe Val 1140 1145 1150 Phe Ser Gln Glu Met Val
Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 1155 1160 1165 Asp Pro 1170
<210> SEQ ID NO 81 <211> LENGTH: 1516 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 81 Met
Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 1 5 10
15 Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp
20 25 30 Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro
Glu Pro 35 40 45 Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr
Thr Thr His Val 50 55 60 Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala
Thr Ala Pro Gly Ser Pro 65 70 75 80 Glu Pro Pro Ser Glu Leu Leu Glu
Asp Gly Gln Asp Thr Pro Thr Ser 85 90 95 Ala Glu Ser Pro Asp Ala
Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 100 105 110 Glu Ile Leu Asn
Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 115 120 125 Asn Asp
Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 130 135 140
Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 145
150 155 160 Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile
Pro Ser 165 170 175 Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu
Pro Ala Pro Thr 180 185 190 Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp
Ala Pro Leu Thr Gly Pro 195 200 205 Ser Val Pro Pro Pro Ser Ser Glu
Arg Ile Ser Glu Glu Val Gly Leu 210 215 220 Leu Gln Leu Leu Gly Asp
Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 225 230 235 240 Asp Pro Asp
Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 245 250 255 Gly
Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 260 265
270 Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu
275 280 285 Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly
Val Lys 290 295 300 Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser
Leu Leu Tyr Thr 305 310 315 320 Glu Pro Gly Ala Gly Gln Thr His Thr
Ala Ala Ser Phe Arg Leu Pro 325 330 335 Ala Phe Val Gly Gln Trp Thr
His Leu Ala Leu Ser Val Ala Gly Gly 340 345 350 Phe Val Ala Leu Tyr
Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 355 360 365 Ala Arg Ser
Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 370 375 380 Val
Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 385 390
395 400 Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His
Cys 405 410 415 Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly
Asp Ser Gly 420 425 430 Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg
Glu Glu Thr Gly Ala 435 440 445 Ala Leu Lys Pro Arg Leu Pro Ala Pro
Pro Pro Val Thr Thr Pro Pro 450 455 460 Leu Ala Gly Gly Ser Ser Thr
Glu Asp Ser Arg Ser Glu Glu Val Glu 465 470 475 480 Glu Gln Thr Thr
Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 485 490 495 Asp Ser
Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 500 505 510
Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 515
520 525 Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro
Gly 530 535 540 Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro
Ala Gly Pro 545 550 555 560 Ala Leu Gln Thr Val Pro Gly Pro Gln Gly
Pro Pro Gly Pro Pro Gly 565 570 575 Arg Asp Gly Thr Pro Gly Arg Asp
Gly Glu Pro Gly Asp Pro Gly Glu 580 585 590 Asp Gly Lys Pro Gly Asp
Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 595 600 605 Gly Asp Val Gly
Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 610 615 620 Arg Gly
Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 625 630 635
640 Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe
645 650 655 Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro
Gly Pro 660 665 670 Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu
Pro Gly Arg Phe 675 680 685 Gly Val Asn Ser Ser Asp Val Pro Gly Pro
Ala Gly Leu Pro Gly Val 690 695 700 Pro Gly Arg Glu Gly Pro Pro Gly
Phe Pro Gly Leu Pro Gly Pro Pro 705 710 715 720 Gly Pro Pro Gly Arg
Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 725 730 735 Ser Leu Gly
Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 740 745 750 Pro
Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 755 760
765 Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly
770 775 780 Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly
Gly Pro 785 790 795 800 Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro
Gln Gly Pro Pro Gly 805 810 815 Leu Pro Gly Leu Lys Gly Asp Pro Gly
Val Pro Gly Leu Pro Gly Ala 820 825 830 Lys Gly Glu Val Gly Ala Asp
Gly Val Pro Gly Phe Pro Gly Leu Pro 835 840 845 Gly Arg Glu Gly Ile
Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 850 855 860 Ser Arg Gly
Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 865 870 875 880
Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 885
890 895 Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg
Pro 900 905 910 Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly
Asn Leu Gly 915 920 925 Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys
Gly Glu Lys Gly Glu 930 935 940 Pro Gly Ser Ile Phe Ser Pro Asp Gly
Gly Ala Leu Gly Pro Ala Gln 945 950 955 960 Lys Gly Ala Lys Gly Glu
Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 965 970 975 Gly Arg Pro Gly
Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 980 985 990 Arg Pro
Gly Met Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp 995 1000
1005 Ala Ser Leu Gly Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly
Pro 1010 1015 1020 Pro Gly Pro Pro Gly Pro Pro Gly Thr Pro Val Tyr
Asp Ser Asn Val 1025 1030 1035 1040 Phe Ala Glu Ser Ser Arg Pro Gly
Pro Pro Gly Leu Pro Gly Asn Gln 1045 1050 1055 Gly Pro Pro Gly Pro
Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly 1060 1065 1070 Pro Pro
Gly Gln Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met 1075 1080
1085 Lys Gly Glu Lys Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu
Arg 1090 1095 1100 Gly Glu Pro Gly Gly Gly Gly Phe Phe Gly Ser Ser
Leu Pro Gly Pro 1105 1110 1115 1120 Pro Gly Pro Pro Gly Pro Arg Gly
Tyr Pro Gly Ile Pro Gly Pro Lys 1125 1130 1135 Gly Glu Ser Ile Arg
Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro 1140 1145 1150 Pro Gly
Ile Gly Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly 1155 1160
1165 Pro Pro Gly Pro Pro Ser Phe Pro Gly Pro His Arg Gln Thr Ile
Ser 1170 1175 1180 Val Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly
Pro Pro Gly Thr 1185 1190 1195 1200 Met Gly Ala Ser Ser Gly Val Arg
Leu Trp Ala Thr Arg Gln Ala Met 1205 1210 1215 Leu Gly Gln Val His
Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala 1220 1225 1230 Glu Gln
Glu Glu Leu Tyr Val Arg Val Gln Asn Gly Phe Arg Lys Val 1235 1240
1245 Gln Leu Glu Ala Arg Thr Pro Leu Pro Arg Gly Thr Asp Asn Glu
Val 1250 1255 1260 Ala Ala Leu Gln Pro Pro Val Val Gln Leu His Asp
Ser Asn Pro Tyr 1265 1270 1275 1280 Pro Arg Arg Glu His Pro His Pro
Thr Ala Arg Pro Trp Arg Ala Asp 1285 1290 1295 Asp Ile Leu Ala Ser
Pro Pro Arg Leu Pro Glu Pro Gln Pro Tyr Pro 1300 1305 1310 Gly Ala
Pro His His Ser Ser Tyr Val His Leu Arg Pro Ala Arg Pro 1315 1320
1325 Thr Ser Pro Pro Ala His Ser His Arg Asp Phe Gln Pro Val Leu
His 1330 1335 1340 Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met
Arg Gly Ile Arg 1345 1350 1355 1360 Gly Ala Asp Phe Gln Cys Phe Gln
Gln Ala Arg Ala Val Gly Leu Ala 1365 1370 1375 Gly Thr Phe Arg Ala
Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser 1380 1385 1390 Ile Val
Arg Arg Ala Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys 1395 1400
1405 Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser
Glu 1410 1415 1420 Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser Phe
Asp Gly Lys Asp 1425 1430 1435 1440 Val Leu Arg His Pro Thr Trp Pro
Gln Lys Ser Val Trp His Gly Ser 1445 1450 1455 Asp Pro Asn Gly Arg
Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg 1460 1465 1470 Thr Glu
Ala Pro Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly 1475 1480
1485 Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile
Val 1490 1495 1500 Leu Cys Ile Glu Asn Ser Phe Met Thr Ala Ser Lys
1505 1510 1515 <210> SEQ ID NO 82 <211> LENGTH: 1336
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 82 Met Ala Pro Arg Cys Pro Trp Pro Trp Pro
Arg Arg Arg Arg Leu Leu 1 5 10 15 Asp Val Leu Ala Pro Leu Val Leu
Leu Leu Gly Val Arg Ala Ala Ser 20 25 30 Ala Glu Pro Glu Arg Ile
Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 35 40 45 Gly Asp Pro Pro
Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 50 55 60 Gly Leu
Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 65 70 75 80
Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 85
90 95 His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile
Thr 100 105 110 Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu
Ser Gly Val 115 120 125 Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr
Thr Glu Pro Gly Ala 130 135 140 Gly Gln Thr His Thr Ala Ala Ser Phe
Arg Leu Pro Ala Phe Val Gly 145 150 155 160 Gln Trp Thr His Leu Ala
Leu Ser Val Ala Gly Gly Phe Val Ala Leu 165 170 175 Tyr Val Asp Cys
Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 180 185 190 Arg Gly
Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 195 200 205
Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 210
215 220 Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu
Glu 225 230 235 240 Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly
Ser Gly Leu Gly 245 250 255 Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr
Gly Ala Ala Leu Lys Pro 260 265 270 Arg Leu Pro Ala Pro Pro Pro Val
Thr Thr Pro Pro Leu Ala Gly Gly 275 280 285 Ser Ser Thr Glu Asp Ser
Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 290 295 300 Val Ala Ser Leu
Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser 305 310 315 320 Thr
Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly 325 330
335 Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly
340 345 350 Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro
Gly Leu 355 360 365 Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro
Ala Leu Gln Thr 370 375 380 Val Pro Gly Pro Gln Gly Pro Pro Gly Pro
Pro Gly Arg Asp Gly Thr 385 390 395 400 Pro Gly Arg Asp Gly Glu Pro
Gly Asp Pro Gly Glu Asp Gly Lys Pro 405 410 415 Gly Asp Thr Gly Pro
Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 420 425 430 Pro Lys Gly
Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro 435 440 445 Gly
Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp 450 455
460 Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu
465 470 475 480 Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro
Gly Pro Pro 485 490 495 Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg
Phe Gly Val Asn Ser 500 505 510 Ser Asp Val Pro Gly Pro Ala Gly Leu
Pro Gly Val Pro Gly Arg Glu 515 520 525 Gly Pro Pro Gly Phe Pro Gly
Leu Pro Gly Pro Pro Gly Pro Pro Gly 530 535 540 Arg Glu Gly Pro Pro
Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 545 550 555 560 Ala Gly
Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala 565 570 575
Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro Gly Pro Ala Gly 580
585 590 Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Leu
Pro 595 600 605 Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro Phe
Trp Ser Thr 610 615 620 Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro
Gly Leu Pro Gly Leu 625 630 635 640 Lys Gly Asp Pro Gly Val Pro Gly
Leu Pro Gly Ala Lys Gly Glu Val 645 650 655 Gly Ala Asp Gly Val Pro
Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 660 665 670 Ile Ala Gly Pro
Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu 675 680 685 Lys Gly
Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu Pro Gly 690 695 700
Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu Gln Asp Gly 705
710 715 720 Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly Phe
Ala Gly 725 730 735 Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly
Ser Lys Gly Glu 740 745 750 Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys
Gly Glu Pro Gly Ser Ile 755 760 765 Phe Ser Pro Asp Gly Gly Ala Leu
Gly Pro Ala Gln Lys Gly Ala Lys 770 775 780 Gly Glu Pro Gly Phe Arg
Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 785 790 795 800 Tyr Lys Gly
Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly Met 805 810 815 Asn
Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala Ser Leu Gly 820 825
830 Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro
835 840 845 Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe Ala
Glu Ser 850 855 860 Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln
Gly Pro Pro Gly 865 870 875 880 Pro Lys Gly Ala Lys Gly Glu Val Gly
Pro Pro Gly Pro Pro Gly Gln 885 890 895 Phe Pro Phe Asp Phe Leu Gln
Leu Glu Ala Glu Met Lys Gly Glu Lys 900 905 910 Gly Asp Arg Gly Asp
Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 915 920 925 Gly Gly Gly
Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro 930 935 940 Gly
Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly Glu Ser Ile 945 950
955 960 Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile
Gly 965 970 975 Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro
Pro Gly Pro 980 985 990 Pro Ser Phe Pro Gly Pro His Arg Gln Thr Ile
Ser Val Pro Gly Pro 995 1000 1005 Pro Gly Pro Pro Gly Pro Pro Gly
Pro Pro Gly Thr Met Gly Ala Ser 1010 1015 1020 Ser Gly Val Arg Leu
Trp Ala Thr Arg Gln Ala Met Leu Gly Gln Val 1025 1030 1035 1040 His
Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala Glu Gln Glu Glu 1045
1050 1055 Leu Tyr Val Arg Val Gln Asn Gly Phe Arg Lys Val Gln Leu
Glu Ala 1060 1065 1070 Arg Thr Pro Leu Pro Arg Gly Thr Asp Asn Glu
Val Ala Ala Leu Gln 1075 1080 1085 Pro Pro Val Val Gln Leu His Asp
Ser Asn Pro Tyr Pro Arg Arg Glu 1090 1095 1100 His Pro His Pro Thr
Ala Arg Pro Trp Arg Ala Asp Asp Ile Leu Ala 1105 1110 1115 1120 Ser
Pro Pro Arg Leu Pro Glu Pro Gln Pro Tyr Pro Gly Ala Pro His 1125
1130 1135 His Ser Ser Tyr Val His Leu Arg Pro Ala Arg Pro Thr Ser
Pro Pro 1140 1145 1150 Ala His Ser His Arg Asp Phe Gln Pro Val Leu
His Leu Val Ala Leu 1155 1160 1165 Asn Ser Pro Leu Ser Gly Gly Met
Arg Gly Ile Arg Gly Ala Asp Phe 1170 1175 1180 Gln Cys Phe Gln Gln
Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg 1185 1190 1195 1200 Ala
Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg 1205
1210 1215 Ala Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu
Leu Leu 1220 1225 1230 Phe Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser
Glu Gly Pro Leu Lys 1235 1240 1245 Pro Gly Ala Arg Ile Phe Ser Phe
Asp Gly Lys Asp Val Leu Arg His 1250 1255 1260 Pro Thr Trp Pro Gln
Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 1265 1270 1275 1280 Arg
Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 1285
1290 1295 Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu
Leu Gly 1300 1305 1310 Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile
Val Leu Cys Ile Glu 1315 1320 1325 Asn Ser Phe Met Thr Ala Ser Lys
1330 1335 <210> SEQ ID NO 83 <211> LENGTH: 1670
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 83 Met Ser Ala Arg Thr Ala Pro Arg Pro Gln
Val Leu Leu Leu Pro Leu 1 5 10 15 Leu Leu Val Leu Leu Ala Ala Ala
Pro Ala Ala Ser Lys Gly Cys Val 20 25 30 Cys Lys Asp Lys Gly Gln
Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 35 40 45 Gly Glu Lys Gly
Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 50 55 60 Phe Thr
Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 65 70 75 80
Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 85
90 95 Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro
Gly 100 105 110 Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys
Ser Gly Ser 115 120 125 Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly
Thr Leu Gly Tyr Pro 130 135 140 Gly Ile Pro Gly Ala Ala Gly Leu Lys
Gly Gln Lys Gly Ala Pro Ala 145 150 155 160 Lys Glu Glu Asp Ile Glu
Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 165 170 175 Gly Ala Pro Gly
Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 180 185 190 Pro Val
Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 195 200 205
Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 210
215 220 His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly
Pro 225 230 235 240 Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp
Asn Arg Thr Asp 245 250 255 Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala
Met Gly Glu Pro Gly Pro 260 265 270 Pro Gly Pro Ser Gly Leu Pro Gly
Glu Ser Tyr Gly Ser Glu Lys Gly 275 280 285 Ala Pro Gly Asp Pro Gly
Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 290 295 300 Pro Gly Phe Pro
Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 305 310 315 320 Gly
Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 325 330
335 Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu
340 345 350 Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly
Ala Arg 355 360 365 Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro
Gly Ser Pro Gly 370 375 380 Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro
Gly Trp Pro Gly Leu Lys 385 390 395 400 Gly Ser Lys Gly Glu Arg Gly
Arg Pro Gly Lys Asp Ala Met Gly Thr 405 410 415 Pro Gly Ser Pro Gly
Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 420 425 430 Gly Pro Pro
Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 435 440 445 Gly
Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 450 455
460 Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro
465 470 475 480 Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly
Leu His Gly 485 490 495 Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala
Gly Leu Lys Gly Ser 500 505 510 Pro Gly Ser Pro Gly Asn Thr Gly Leu
Pro Gly Phe Pro Gly Phe Pro 515 520 525 Gly Ala Gln Gly Asp Pro Gly
Leu Lys Gly Glu Lys Gly Glu Thr Leu 530 535 540 Gln Pro Glu Gly Gln
Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 545 550 555 560 Gln Pro
Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 565 570 575
Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 580
585 590 Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro
Gly 595 600 605 Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln
Gly Glu Pro 610 615 620 Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala
Pro Gly Pro Pro Gly 625 630 635 640 Glu Ala Gly Pro Arg Gly Glu Leu
Ser Val Ser Thr Pro Val Pro Gly 645 650 655 Pro Pro Gly Pro Pro Gly
Pro Pro Gly His Pro Gly Pro Gln Gly Pro 660 665 670 Pro Gly Ile Pro
Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 675 680 685 Gly Pro
Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 690 695 700
Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 705
710 715 720 Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys
Pro Gly 725 730 735 Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met
Pro Gly Gly Pro 740 745 750 Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly
Asn Ser Gly Glu His Gly 755 760 765 Glu Ile Gly Leu Pro Gly Leu Pro
Gly Leu Pro Gly Thr Pro Gly Asn 770 775 780 Glu Gly Leu Asp Gly Pro
Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 785 790 795 800 Gly Glu Gln
Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 805 810 815 Gln
Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 820 825
830 Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg
835 840 845 Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly
His Gln 850 855 860 Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro
Gly Asn Pro Gly 865 870 875 880 Ile Leu Gly Pro Pro Gly Glu Asp Gly
Val Ile Gly Met Met Gly Phe 885 890 895 Pro Gly Ala Ile Gly Pro Pro
Gly Pro Pro Gly Asn Pro Gly Thr Pro 900 905 910 Gly Gln Arg Gly Ser
Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 915 920 925 Thr Pro Gly
Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 930 935 940 Ser
Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 945 950
955 960 Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro
Gly 965 970 975 Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro
Ala Gly Pro 980 985 990 Pro Gly Pro Arg Gly Asp Leu Gly Ser Thr Gly
Asn Pro Gly Glu Pro 995 1000 1005 Gly Leu Arg Gly Ile Pro Gly Ser
Met Gly Asn Met Gly Met Pro Gly 1010 1015 1020 Ser Lys Gly Lys Arg
Gly Thr Leu Gly Phe Pro Gly Arg Ala Gly Arg 1025 1030 1035 1040 Pro
Gly Leu Pro Gly Ile His Gly Leu Gln Gly Asp Lys Gly Glu Pro 1045
1050 1055 Gly Tyr Ser Glu Gly Thr Arg Pro Gly Pro Pro Gly Pro Thr
Gly Asp 1060 1065 1070 Pro Gly Leu Pro Gly Asp Met Gly Lys Lys Gly
Glu Met Gly Gln Pro 1075 1080 1085 Gly Pro Pro Gly His Leu Gly Pro
Ala Gly Pro Glu Gly Ala Pro Gly 1090 1095 1100 Ser Pro Gly Ser Pro
Gly Leu Pro Gly Lys Pro Gly Pro His Gly Asp 1105 1110 1115 1120 Leu
Gly Phe Lys Gly Ile Lys Gly Leu Leu Gly Pro Pro Gly Ile Arg 1125
1130 1135 Gly Pro Pro Gly Leu Pro Gly Phe Pro Gly Ser Pro Gly Pro
Met Gly 1140 1145 1150 Ile Arg Gly Asp Gln Gly Arg Asp Gly Ile Pro
Gly Pro Ala Gly Glu 1155 1160 1165 Lys Gly Glu Thr Gly Leu Leu Arg
Ala Pro Pro Gly Pro Arg Gly Asn 1170 1175 1180 Pro Gly Ala Gln Gly
Ala Lys Gly Asp Arg Gly Ala Pro Gly Phe Pro 1185 1190 1195 1200 Gly
Leu Pro Gly Arg Lys Gly Ala Met Gly Asp Ala Gly Pro Arg Gly 1205
1210 1215 Pro Thr Gly Ile Glu Gly Phe Pro Gly Pro Pro Gly Leu Pro
Gly Ala 1220 1225 1230 Ile Ile Pro Gly Gln Thr Gly Asn Arg Gly Pro
Pro Gly Ser Arg Gly 1235 1240 1245 Ser Pro Gly Ala Pro Gly Pro Pro
Gly Pro Pro Gly Ser His Val Ile 1250 1255 1260 Gly Ile Lys Gly Asp
Lys Gly Ser Met Gly His Pro Gly Pro Lys Gly 1265 1270 1275 1280 Pro
Pro Gly Thr Ala Gly Asp Met Gly Pro Pro Gly Arg Leu Gly Ala 1285
1290 1295 Pro Gly Thr Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly
Phe Gln 1300 1305 1310 Gly Phe Pro Gly Val Lys Gly Glu Lys Gly Asn
Pro Gly Phe Leu Gly 1315 1320 1325 Ser Ile Gly Pro Pro Gly Pro Ile
Gly Pro Lys Gly Pro Pro Gly Val 1330 1335 1340 Arg Gly Asp Pro Gly
Thr Leu Lys Ile Ile Ser Leu Pro Gly Ser Pro 1345 1350 1355 1360 Gly
Pro Pro Gly Thr Pro Gly Glu Pro Gly Met Gln Gly Glu Pro Gly 1365
1370 1375 Pro Pro Gly Pro Pro Gly Asn Leu Gly Pro Cys Gly Pro Arg
Gly Lys 1380 1385 1390 Pro Gly Lys Asp Gly Lys Pro Gly Thr Pro Gly
Pro Ala Gly Glu Lys 1395 1400 1405 Gly Asn Lys Gly Ser Lys Gly Glu
Pro Gly Pro Ala Gly Ser Asp Gly 1410 1415 1420 Leu Pro Gly Leu Lys
Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr 1425 1430 1435 1440 Trp
Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala 1445
1450 1455 Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly
Phe Ser 1460 1465 1470 Phe Leu Phe Val Gln Gly Asn Gln Arg Ala His
Gly Gln Asp Leu Gly 1475 1480 1485 Thr Leu Gly Ser Cys Leu Gln Arg
Phe Thr Thr Met Pro Phe Leu Phe 1490 1495 1500 Cys Asn Val Asn Asp
Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser 1505 1510 1515 1520 Tyr
Trp Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met Ala Pro Ile 1525
1530 1535 Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val
Cys Glu 1540 1545 1550 Gly Pro Ala Ile Ala Ile Ala Val His Ser Gln
Thr Thr Asp Ile Pro 1555 1560 1565 Pro Cys Pro His Gly Trp Ile Ser
Leu Trp Lys Gly Phe Ser Phe Ile 1570 1575 1580 Met Phe Thr Ser Ala
Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser 1585 1590 1595 1600 Pro
Gly Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys 1605
1610 1615 His Gly Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser
Phe Trp 1620 1625 1630 Leu Ala Ser Leu Asn Pro Glu Arg Met Phe Arg
Lys Pro Ile Pro Ser 1635 1640 1645 Thr Val Lys Ala Gly Glu Leu Glu
Lys Ile Ile Ser Arg Cys Gln Val 1650 1655 1660 Cys Met Lys Lys Arg
His 1665 1670 <210> SEQ ID NO 84 <211> LENGTH: 1712
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 84 Met Gly Arg Asp Gln Arg Ala Val Ala Gly
Pro Ala Leu Arg Arg Trp 1 5 10 15 Leu Leu Leu Gly Thr Val Thr Val
Gly Phe Leu Ala Gln Ser Val Leu 20 25 30 Ala Gly Val Lys Lys Phe
Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 35 40 45 Gly Gly Cys Gln
Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 50 55 60 Pro Val
Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 65 70 75 80
Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 85
90 95 Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser
Gly 100 105 110 Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln
Gly Gly Pro 115 120 125 Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly
Thr Gln Gly Asp Ser 130 135 140 Gly Pro Gln Gly Pro Pro Gly Ser Glu
Gly Phe Thr Gly Pro Pro Gly 145 150 155 160 Pro Gln Gly Pro Lys Gly
Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 165 170 175 Glu Glu Arg Asp
Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 180 185 190 Gly Phe
Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 195 200 205
Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 210
215 220 Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys
Gly 225 230 235 240 Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly
Ile Pro Ser Asp 245 250 255 Thr Leu His Pro Ile Ile Ala Pro Thr Gly
Val Thr Phe His Pro Asp 260 265 270 Gln Tyr Lys Gly Glu Lys Gly Ser
Glu Gly Glu Pro Gly Ile Arg Gly 275 280 285 Ile Ser Leu Lys Gly Glu
Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 290 295 300 Gly Tyr Pro Gly
Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 305 310 315 320 Ser
Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 325 330
335 Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser
340 345 350 Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly
Phe Pro 355 360 365 Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro
Gly Asp Pro Gly 370 375 380 Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly
Asp Gly Asp Gln Arg Arg 385 390 395 400 Gly Leu Pro Gly Glu Met Gly
Pro Lys Gly Phe Ile Gly Asp Pro Gly 405 410 415 Ile Pro Ala Leu Tyr
Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 420 425 430 Pro Pro Gly
Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 435 440 445 Leu
Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 450 455
460 Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala
465 470 475 480 Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys
Gly Leu Pro 485 490 495 Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile
Asn Gly Glu Pro Gly 500 505 510 Arg Lys Gly Asp Arg Gly Asp Pro Gly
Gln His Gly Leu Pro Gly Phe 515 520 525 Pro Gly Leu Lys Gly Val Pro
Gly Asn Ile Gly Ala Pro Gly Pro Lys 530 535 540 Gly Ala Lys Gly Asp
Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 545 550 555 560 Gln Pro
Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 565 570 575
Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 580
585 590 Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly
Ile 595 600 605 Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro
Gly Leu Gly 610 615 620 Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro
Gly Asp Ala Gly Leu 625 630 635 640 Pro Gly Pro Pro Gly Phe Leu Gly
Pro Pro Gly Pro Ala Gly Thr Pro 645 650 655 Gly Gln Ile Asp Cys Asp
Thr Asp Val Lys Arg Ala Val Gly Gly Asp 660 665 670 Arg Gln Glu Ala
Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 675 680 685 Pro Gly
Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 690 695 700
Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 705
710 715 720 Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro
Gly Phe 725 730 735 Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu
Pro Gly Pro Asp 740 745 750 Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly
Pro Asp Gly Pro Pro Gly 755 760 765 Glu Arg Gly Leu Pro Gly Glu Val
Leu Gly Ala Gln Pro Gly Pro Arg 770 775 780 Gly Asp Ala Gly Val Pro
Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 785 790 795 800 Asp Arg Gly
Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 805 810 815 Pro
Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 820 825
830 Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly
835 840 845 Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu
Gly Leu 850 855 860 Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala
Pro Gly Pro Val 865 870 875 880 Gly Met Lys Gly Leu Ser Gly Asp Arg
Gly Asp Ala Gly Phe Thr Gly 885 890 895 Glu Gln Gly His Pro Gly Ser
Pro Gly Phe Lys Gly Ile Asp Gly Met 900 905 910 Pro Gly Thr Pro Gly
Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 915 920 925 Gly Phe Gln
Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 930 935 940 Ser
Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 945 950
955 960 Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro
Pro 965 970 975 Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile
Lys Gly Glu 980 985 990 Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly
Tyr Leu Gly Ala Lys 995 1000 1005 Gly Ile Gln Gly Met Pro Gly Ile
Pro Gly Leu Ser Gly Ile Pro Gly 1010 1015 1020 Leu Pro Gly Arg Pro
Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly 1025 1030 1035 1040 Val
Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro 1045
1050 1055 Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly
Asp Lys 1060 1065 1070 Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu
Ile Gly Ala Thr Gly 1075 1080 1085 Asp Phe Gly Asp Ile Gly Asp Thr
Ile Asn Leu Pro Gly Arg Pro Gly 1090 1095 1100 Leu Lys Gly Glu Arg
Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe 1105 1110 1115 1120 Phe
Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr 1125
1130 1135 Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln
Thr Gly 1140 1145 1150 Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln
Gly Glu Leu Gly Arg 1155 1160 1165 Ile Gly Leu Pro Gly Gly Lys Gly
Asp Asp Gly Trp Pro Gly Ala Pro 1170 1175 1180 Gly Leu Pro Gly Phe
Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly 1185 1190 1195 1200 Leu
Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His 1205
1210 1215 Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp
Pro Gly 1220 1225 1230 Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val
Pro Gly Gln Lys Gly 1235 1240 1245 Asp Gln Gly Ala Pro Gly Glu Arg
Gly Pro Pro Gly Ser Pro Gly Leu 1250 1255 1260 Gln Gly Phe Pro Gly
Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala Pro 1265 1270 1275 1280 Gly
Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly 1285
1290 1295 Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys
Gly Asp 1300 1305 1310 Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly
Thr Lys Gly Trp Ala 1315 1320 1325 Gly Asp Ser Gly Pro Gln Gly Arg
Pro Gly Val Phe Gly Leu Pro Gly 1330 1335 1340 Glu Lys Gly Pro Arg
Gly Glu Gln Gly Phe Met Gly Asn Thr Gly Pro 1345 1350 1355 1360 Thr
Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro 1365
1370 1375 Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile
Ala Gly 1380 1385 1390 Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr
Val Gly Pro Gln Gly 1395 1400 1405 Arg Arg Gly Pro Pro Gly Ala Pro
Gly Glu Met Gly Pro Gln Gly Pro 1410 1415 1420 Pro Gly Glu Pro Gly
Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln 1425 1430 1435 1440 Gly
Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly 1445
1450 1455 Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro
Gly Arg 1460 1465 1470 Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly
Arg Ser Val Ser Ile 1475 1480 1485 Gly Tyr Leu Leu Val Lys His Ser
Gln Thr Asp Gln Glu Pro Met Cys 1490 1495 1500 Pro Val Gly Met Asn
Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe 1505 1510 1515 1520 Glu
Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser 1525
1530 1535 Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn
Pro Gly 1540 1545 1550 Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys
Ser Tyr Trp Leu Ser 1555 1560 1565 Thr Thr Ala Pro Leu Pro Met Met
Pro Val Ala Glu Asp Glu Ile Lys 1570 1575 1580 Pro Tyr Ile Ser Arg
Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile 1585 1590 1595 1600 Ala
Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp 1605
1610 1615 Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala
Ala Gly 1620 1625 1630 Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro
Gly Ser Cys Leu Glu 1635 1640 1645 Asp Phe Arg Ala Thr Pro Phe Ile
Glu Cys Asn Gly Gly Arg Gly Thr 1650 1655 1660 Cys His Tyr Tyr Ala
Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro 1665 1670 1675 1680 Glu
Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly 1685
1690 1695 Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys
Asn Leu 1700 1705 1710 <210> SEQ ID NO 85 <211> LENGTH:
1427 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 85 Met Ser Met Leu Lys Pro Ser Gly Leu Lys
Ala Pro Thr Lys Ile Leu 1 5 10 15 Lys Pro Gly Ser Thr Ala Leu Lys
Thr Pro Thr Ala Val Val Ala Pro 20 25 30 Val Glu Lys Thr Ile Ser
Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 35 40 45 Glu Thr Gln Glu
Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 50 55 60 Trp Val
Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 65 70 75 80
Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 85
90 95 Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys
Glu 100 105 110 Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr
Arg Lys Val 115 120 125 Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr
Thr Pro Ala Ser Arg 130 135 140 Ala Thr Ser Pro Leu Cys Thr Ser Thr
Ala Ser Met Val Ser Ser Ser 145 150 155 160 Pro Ser Thr Pro Ser Asn
Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 165 170 175 Lys Glu Pro Ser
Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 180 185 190 Ser Glu
Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 195 200 205
Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 210
215 220 Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly
Glu 225 230 235 240 Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys
Asn Asp Gly Ala 245 250 255 Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln
Pro Lys Tyr Gly Leu Phe 260 265 270 Ala Pro Val His Lys Val Thr Lys
Ile Gly Phe Pro Ser Thr Thr Pro 275 280 285 Ala Lys Ala Lys Ala Asn
Ala Val Arg Arg Val Met Ala Thr Thr Ser 290 295 300 Ala Ser Leu Lys
Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 305 310 315 320 Ser
Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 325 330
335 Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala
340 345 350 Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln
Leu Leu 355 360 365 Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys
Ala Thr Ser His 370 375 380 Val Gly Glu Ile Glu Gln Glu Leu Ala Leu
Ala Arg Asp Gly His Asp 385 390 395 400 Gln His Val Leu Glu Leu Glu
Ala Lys Met Asp Gln Leu Arg Thr Met 405 410 415 Val Glu Ala Ala Asp
Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 420 425 430 Glu Glu Lys
Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 435 440 445 Ser
Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Lys Leu Glu His Ala 450 455
460 Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala
465 470 475 480 Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg Val Ala
Thr Val Ser 485 490 495 Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp
Leu Ala Leu Arg Val 500 505 510 Gln Glu Val Ala Glu Leu Arg Arg Arg
Leu Glu Ser Asn Lys Pro Ala 515 520 525 Gly Asp Val Asp Met Ser Leu
Ser Leu Leu Gln Glu Ile Ser Ser Leu 530 535 540 Gln Glu Lys Leu Glu
Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr 545 550 555 560 Ser Leu
Lys Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu 565 570 575
Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu 580
585 590 Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp
Val 595 600 605 Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala
Ser His Gln 610 615 620 Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser
Lys Gly Leu Gly Thr 625 630 635 640 Glu Thr Ala Glu Phe Ala Glu Leu
Lys Thr Gln Ile Glu Lys Met Arg 645 650 655 Leu Asp Tyr Gln His Glu
Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser 660 665 670 Glu Arg Ala Ala
His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu 675 680 685 Met Lys
Val Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser 690 695 700
Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr 705
710 715 720 Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu
Glu Val 725 730 735 Leu Gln Ala Lys Cys Asn Glu Gln Thr Lys Val Ile
Asp Asn Phe Thr 740 745 750 Ser Gln Leu Lys Ala Thr Glu Glu Lys Leu
Leu Asp Leu Asp Ala Leu 755 760 765 Arg Lys Ala Ser Ser Glu Gly Lys
Ser Glu Met Lys Lys Leu Arg Gln 770 775 780 Gln Leu Glu Ala Ala Glu
Lys Gln Ile Lys His Leu Glu Ile Glu Lys 785 790 795 800 Asn Ala Glu
Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly 805 810 815 Arg
Glu Leu Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser 820 825
830 Gln Val Lys Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys
835 840 845 Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser
Met Gln 850 855 860 Glu Thr Val Asn Lys Leu His Gln Lys Glu Glu Gln
Phe Asn Met Leu 865 870 875 880 Ser Ser Asp Leu Glu Lys Leu Arg Glu
Asn Leu Ala Asp Met Glu Ala 885 890 895 Lys Phe Arg Glu Lys Asp Glu
Arg Glu Glu Gln Leu Ile Lys Ala Lys 900 905 910 Glu Lys Leu Glu Asn
Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp 915 920 925 Asn Ser Ser
Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu 930 935 940 Arg
Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn 945 950
955 960 Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala
Glu 965 970 975 Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu
Lys Lys Glu 980 985 990 Leu Glu Arg Lys Leu Ser Asp Leu Glu Lys Lys
Met Glu Thr Ser His 995 1000 1005 Asn Gln Cys Gln Glu Leu Lys Ala
Arg Tyr Glu Arg Ala Thr Ser Glu 1010 1015 1020 Thr Lys Thr Lys His
Glu Glu Ile Leu Gln Asn Leu Gln Lys Thr Leu 1025 1030 1035 1040 Leu
Asp Thr Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn Ser Gly 1045
1050 1055 Leu Leu Gln Glu Leu Glu Glu Leu Arg Lys Gln Ala Asp Lys
Ala Lys 1060 1065 1070 Ala Ala Gln Thr Ala Glu Asp Ala Met Gln Ile
Met Glu Gln Met Thr 1075 1080 1085 Lys Glu Lys Thr Glu Thr Leu Ala
Ser Leu Glu Asp Thr Lys Gln Thr 1090 1095 1100 Asn Ala Lys Leu Gln
Asn Glu Leu Asp Thr Leu Lys Glu Asn Asn Leu 1105 1110 1115 1120 Lys
Asn Val Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr Val Glu 1125
1130 1135 Asn Gln Lys Met Glu Glu Phe Arg Lys Glu Ile Glu Thr Leu
Lys Gln 1140 1145 1150 Ala Ala Ala Gln Lys Ser Gln Gln Leu Ser Ala
Leu Gln Glu Glu Asn 1155 1160 1165 Val Lys Leu Ala Glu Glu Leu Gly
Arg Ser Arg Asp Glu Val Thr Ser 1170 1175 1180 His Gln Lys Leu Glu
Glu Glu Arg Ser Val Leu Asn Asn Gln Leu Leu 1185 1190 1195 1200 Glu
Met Lys Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp Glu Glu 1205
1210 1215 Lys Ala Ser Leu Gln Lys Ser Ile Ser Ile Thr Ser Ala Leu
Leu Thr 1220 1225 1230 Glu Lys Asp Ala Glu Leu Glu Lys Leu Arg Asn
Glu Val Thr Val Leu 1235 1240 1245 Arg Gly Glu Asn Ala Ser Ala Lys
Ser Leu His Ser Val Val Gln Thr 1250 1255 1260 Leu Glu Ser Asp Lys
Val Lys Leu Glu Leu Lys Val Lys Asn Leu Glu 1265 1270 1275 1280 Leu
Gln Leu Lys Glu Asn Lys Arg Gln Leu Ser Ser Ser Ser Gly Asn 1285
1290 1295 Thr Asp Thr Gln Ala Asp Glu Asp Glu Arg Ala Gln Glu Ser
Gln Ile 1300 1305 1310 Asp Phe Leu Asn Ser Val Ile Val Asp Leu Gln
Arg Lys Asn Gln Asp 1315 1320 1325 Leu Lys Met Lys Val Glu Met Met
Ser Glu Ala Ala Leu Asn Gly Asn 1330 1335 1340 Gly Asp Asp Leu Asn
Asn Tyr Asp Ser Asp Asp Gln Glu Lys Gln Ser 1345 1350 1355 1360 Lys
Lys Lys Pro Arg Leu Phe Cys Asp Ile Cys Asp Cys Phe Asp Leu 1365
1370 1375 His Asp Thr Glu Asp Cys Pro Thr Gln Ala Gln Met Ser Glu
Asp Pro 1380 1385 1390 Pro His Ser Thr His His Gly Ser Arg Gly Glu
Glu Arg Pro Tyr Cys 1395 1400 1405 Glu Ile Cys Glu Met Phe Gly His
Trp Ala Thr Asn Cys Asn Asp Asp 1410 1415 1420 Glu Thr Phe 1425
<210> SEQ ID NO 86 <211> LENGTH: 251 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Met
Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 1 5 10
15 Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser
20 25 30 Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe
Leu Ala 35 40 45 Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg
Ala Gln Gly Glu 50 55 60 Ala Cys Val Gln Phe Gln Ala Leu Lys Gly
Gln Glu Phe Ala Pro Ser 65 70 75 80 His Gln Gln Val Tyr Ala Pro Leu
Arg Ala Asp Gly Asp Lys Pro Arg 85 90 95 Ala His Leu Thr Val Val
Arg Gln Thr Pro Thr Gln His Phe Lys Asn 100 105 110 Gln Phe Pro Ala
Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 115 120 125 Lys Asn
Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 130 135 140
Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 145
150 155 160 Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro
Asp Ser 165 170 175 Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr
Pro Glu Pro Thr 180 185 190 Gln Leu Leu Met Gly Thr Lys Ser Val Cys
Glu Val Gly Ser Asn Trp 195 200 205 Phe Gln Pro Ile Tyr Leu Gly Ala
Met Phe Ser Leu Gln Glu Gly Asp 210 215 220 Lys Leu Met Val Asn Val
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 225 230 235 240 Glu Asp Lys
Thr Phe Phe Gly Ala Phe Leu Leu 245 250 <210> SEQ ID NO 87
<211> LENGTH: 498 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 87 Met Thr Val Phe Leu Ser Phe
Ala Phe Leu Ala Ala Ile Leu Thr His 1 5 10 15 Ile Gly Cys Ser Asn
Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 20 25 30 Tyr Asn Arg
Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 35 40 45 Glu
His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 50 55
60 Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser
65 70 75 80 Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr
Gln Trp 85 90 95 Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met
Lys Ser Glu Met 100 105 110 Ala Gln Ile Gln Gln Asn Ala Val Gln Asn
His Thr Ala Thr Met Leu 115 120 125 Glu Ile Gly Thr Ser Leu Leu Ser
Gln Thr Ala Glu Gln Thr Arg Lys 130 135 140 Leu Thr Asp Val Glu Thr
Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 145 150 155 160 Ile Gln Leu
Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 165 170 175 Leu
Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 180 185
190 Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu
195 200 205 Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu
Val Thr 210 215 220 Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln
Leu Asn Arg Ala 225 230 235 240 Thr Thr Asn Asn Ser Val Leu Gln Lys
Gln Gln Leu Glu Leu Met Asp 245 250 255 Thr Val His Asn Leu Val Asn
Leu Cys Thr Lys Glu Gly Val Leu Leu 260 265 270 Lys Gly Gly Lys Arg
Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp 275 280 285 Val Tyr Gln
Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile 290 295 300 Asn
Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn 305 310
315 320 Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu
Asp 325 330 335 Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly
Asn Pro Ser 340 345 350 Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe
Ala Ile Thr Ser Gln 355 360 365 Arg Gln Tyr Met Leu Arg Ile Glu Leu
Met Asp Trp Glu Gly Asn Arg 370 375 380 Ala Tyr Ser Gln Tyr Asp Arg
Phe His Ile Gly Asn Glu Lys Gln Asn 385 390 395 400 Tyr Arg Leu Tyr
Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser 405 410 415 Ser Leu
Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn 420 425 430
Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp 435
440 445 Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr
Ala 450 455 460 Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His
Tyr Phe Lys 465 470 475 480 Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr
Met Met Ile Arg Pro Leu 485 490 495 Asp Phe <210> SEQ ID NO
88 <211 > LENGTH: 227 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 88 Met Asn Ile Lys Gly
Ser Pro Trp Lys Gly Ser Leu Leu Leu Leu Leu 1 5 10 15 Val Ser Asn
Leu Leu Leu Cys Gln Ser Val Ala Pro Leu Pro Ile Cys 20 25 30 Pro
Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 35 40
45 Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met
50 55 60 Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe
Ile Thr 65 70 75 80 Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala
Thr Pro Glu Asp 85 90 95 Lys Glu Gln Ala Gln Gln Met Asn Gln Lys
Asp Phe Leu Ser Leu Ile 100 105 110 Val Ser Ile Leu Arg Ser Trp Asn
Glu Pro Leu Tyr His Leu Val Thr 115 120 125 Glu Val Arg Gly Met Gln
Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 130 135 140 Val Glu Ile Glu
Glu Gln Thr Lys Arg Leu Leu Glu Gly Met Glu Leu 145 150 155 160 Ile
Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 165 170
175 Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg
180 185 190 Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp
Ser His 195 200 205 Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg
Ile Ile His Asn 210 215 220 Asn Asn Cys 225 <210> SEQ ID NO
89 <211> LENGTH: 4391 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 89 Met Gly Trp Arg Ala
Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 1 5 10 15 Gly Arg Leu
Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 20 25 30 Ser
Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 35 40
45 Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile
50 55 60 Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp
Phe Gln 65 70 75 80 Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg
Ser Ile Glu Tyr 85 90 95 Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg
Glu Phe Arg Glu Val Ser 100 105 110 Glu Ala Val Val Asp Thr Leu Glu
Ser Glu Tyr Leu Lys Ile Pro Gly 115 120 125 Asp Gln Val Val Ser Val
Val Phe Ile Lys Glu Leu Asp Gly Trp Val 130 135 140 Phe Val Glu Leu
Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 145 150 155 160 Ile
Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 165 170
175 Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val
180 185 190 Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys
His Ser 195 200 205 Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp
Arg Arg Pro Asp 210 215 220 Cys Arg Asp Met Ser Asp Glu Leu Asn Cys
Glu Glu Pro Val Leu Gly 225 230 235 240 Ile Ser Pro Thr Phe Ser Leu
Leu Val Glu Thr Thr Ser Leu Pro Pro 245 250 255 Arg Pro Glu Thr Thr
Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 260 265 270 Gln Pro Leu
Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 275 280 285 Glu
Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 290 295
300 Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly
305 310 315 320 Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly
Asn Gly His 325 330 335 Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp
Phe Asp Cys Glu Asp 340 345 350 Arg Thr Asp Glu Ala Asn Cys Pro Thr
Lys Arg Pro Glu Glu Val Cys 355 360 365 Gly Pro Thr Gln Phe Arg Cys
Val Ser Thr Asn Met Cys Ile Pro Ala 370 375 380 Ser Phe His Cys Asp
Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 385 390 395 400 Phe Gly
Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 405 410 415
Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 420
425 430 Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile
Pro 435 440 445 Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg
Gly Thr Leu 450 455 460 Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly
Ala Tyr Thr Cys Glu 465 470 475 480 Ala Met Asn Ala Arg Gly Met Val
Phe Gly Ile Pro Asp Gly Val Leu 485 490 495 Glu Leu Val Pro Gln Arg
Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 500 505 510 Glu His Ser Ala
Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 515 520 525 Val Cys
Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 530 535 540
Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 545
550 555 560 Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp
Pro Ser 565 570 575 Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg
Phe Leu Val His 580 585 590 Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe
Leu Gly Asn Lys Val Asp 595 600 605 Ser Tyr Gly Gly Ser Leu Arg Tyr
Asn Val Arg Tyr Glu Leu Ala Arg 610 615 620 Gly Met Leu Glu Pro Val
Gln Arg Pro Asp Val Val Leu Met Gly Ala 625 630 635 640 Gly Tyr Arg
Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 645 650 655 Leu
Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 660 665
670 Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser
675 680 685 Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met
Ala Ser 690 695 700 Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val
Thr His Ala Thr 705 710 715 720 Ser His Gly Arg Ala His Ser Val Glu
Glu Cys Arg Cys Pro Ile Gly 725 730 735 Tyr Ser Gly Leu Ser Cys Glu
Ser Cys Asp Ala His Phe Thr Arg Val 740 745 750 Pro Gly Gly Pro Tyr
Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 755 760 765 His Ala Ser
Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 770 775 780 His
Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 785 790
795 800 Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro
Cys 805 810 815 Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys
Phe Leu Asp 820 825 830 Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala
Pro Gly Tyr Thr Gly 835 840 845 Arg Arg Cys Glu Ser Cys Ala Pro Gly
Tyr Glu Gly Asn Pro Ile Gln 850 855 860 Pro Gly Gly Lys Cys Arg Pro
Val Asn Gln Glu Ile Val Arg Cys Asp 865 870 875 880 Glu Arg Gly Ser
Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 885 890 895 Asn Val
Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 900 905 910
Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 915
920 925 Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu
His 930 935 940 Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn
Ala Ala Ser 945 950 955 960 Thr His Thr Thr Asn Glu Gly Ile Phe Ser
Pro Thr Pro Gly Glu Leu 965 970 975 Gly Phe Ser Ser Phe His Arg Leu
Leu Ser Gly Pro Tyr Phe Trp Ser 980 985 990 Leu Pro Ser Arg Phe Leu
Gly Asp Lys Val Thr Ser Tyr Gly Gly Glu 995 1000 1005 Leu Arg Phe
Thr Val Thr Gln Arg Ser Gln Pro Gly Ser Thr Pro Leu 1010 1015 1020
His Gly Gln Pro Leu Val Val Leu Gln Gly Asn Asn Ile Ile Leu Glu
1025 1030 1035 1040 His His Val Ala Gln Glu Pro Ser Pro Gly Gln Pro
Ser Thr Phe Ile 1045 1050 1055 Val Pro Phe Arg Glu Gln Ala Trp Gln
Arg Pro Asp Gly Gln Pro Ala 1060 1065 1070 Thr Arg Glu His Leu Leu
Met Ala Leu Ala Gly Ile Asp Thr Leu Leu 1075 1080 1085 Ile Arg Ala
Ser Tyr Ala Gln Gln Pro Ala Glu Ser Arg Val Ser Gly 1090 1095 1100
Ile Ser Met Asp Val Ala Val Pro Glu Glu Thr Gly Gln Asp Pro Ala
1105 1110 1115 1120 Leu Glu Val Glu Gln Cys Ser Cys Pro Pro Gly Tyr
Arg Gly Pro Ser 1125 1130 1135 Cys Gln Asp Cys Asp Thr Gly Tyr Thr
Arg Thr Pro Ser Gly Leu Tyr 1140 1145 1150 Leu Gly Thr Cys Glu Arg
Cys Ser Cys His Gly His Ser Glu Ala Cys 1155 1160 1165 Glu Pro Glu
Thr Gly Ala Cys Gln Gly Cys Gln His His Thr Glu Gly 1170 1175 1180
Pro Arg Cys Glu Gln Cys Gln Pro Gly Tyr Tyr Gly Asp Ala Gln Arg
1185 1190 1195 1200 Gly Thr Pro Gln Asp Cys Gln Leu Cys Pro Cys Tyr
Gly Asp Pro Ala 1205 1210 1215 Ala Gly Gln Ala Ala His Thr Cys Phe
Leu Asp Thr Asp Gly His Pro 1220 1225 1230 Thr Cys Asp Ala Cys Ser
Pro Gly His Ser Gly Arg His Cys Glu Arg 1235 1240 1245 Cys Ala Pro
Gly Tyr Tyr Gly Asn Pro Ser Gln Gly Gln Pro Cys Gln 1250 1255 1260
Arg Asp Ser Gln Val Pro Gly Pro Ile Gly Cys Asn Cys Asp Pro Gln
1265 1270 1275 1280 Gly Ser Val Ser Ser Gln Cys Asp Ala Ala Gly Gln
Cys Gln Cys Lys 1285 1290 1295 Ala Gln Val Glu Gly Leu Thr Cys Ser
His Cys Arg Pro His His Phe 1300 1305 1310 His Leu Ser Ala Ser Asn
Pro Asp Gly Cys Leu Pro Cys Phe Cys Met 1315 1320 1325 Gly Ile Thr
Gln Gln Cys Ala Ser Ser Ala Tyr Thr Arg His Leu Ile 1330 1335 1340
Ser Thr His Phe Ala Pro Gly Asp Phe Gln Gly Phe Ala Leu Val Asn
1345 1350 1355 1360 Pro Gln Arg Asn Ser Arg Leu Thr Gly Glu Phe Thr
Val Glu Pro Val 1365 1370 1375 Pro Glu Gly Ala Gln Leu Ser Phe Gly
Asn Phe Ala Gln Leu Gly His 1380 1385 1390 Glu Ser Phe Tyr Trp Gln
Leu Pro Glu Thr Tyr Gln Gly Asp Lys Val 1395 1400 1405 Ala Ala Tyr
Gly Gly Lys Leu Arg Tyr Thr Leu Ser Tyr Thr Ala Gly 1410 1415 1420
Pro Gln Gly Ser Pro Leu Ser Asp Pro Asp Val Gln Ile Thr Gly Asn
1425 1430 1435 1440 Asn Ile Met Leu Val Ala Ser Gln Pro Ala Leu Gln
Gly Pro Glu Arg 1445 1450 1455 Arg Ser Tyr Glu Ile Met Phe Arg Glu
Glu Phe Trp Arg Arg Pro Asp 1460 1465 1470 Gly Gln Pro Ala Thr Arg
Glu His Leu Leu Met Ala Leu Ala Asp Leu 1475 1480 1485 Asp Glu Leu
Leu Ile Arg Ala Thr Phe Ser Ser Val Pro Leu Ala Ala 1490 1495 1500
Ser Ile Ser Ala Val Ser Leu Glu Val Ala Gln Pro Gly Pro Ser Asn
1505 1510 1515 1520 Arg Pro Arg Ala Leu Glu Val Glu Glu Cys Arg Cys
Pro Pro Gly Tyr 1525 1530 1535 Ile Gly Leu Ser Cys Gln Asp Cys Ala
Pro Gly Tyr Thr Arg Thr Gly 1540 1545 1550 Ser Gly Leu Tyr Leu Gly
His Cys Glu Leu Cys Glu Cys Asn Gly His 1555 1560 1565 Ser Asp Leu
Cys His Pro Glu Thr Gly Ala Cys Ser Gln Cys Gln His 1570 1575 1580
Asn Ala Ala Gly Glu Phe Cys Glu Leu Cys Ala Pro Gly Tyr Tyr Gly
1585 1590 1595 1600 Asp Ala Thr Ala Gly Thr Pro Glu Asp Cys Gln Pro
Cys Ala Cys Pro 1605 1610 1615 Leu Thr Asn Pro Glu Asn Met Phe Ser
Arg Thr Cys Glu Ser Leu Gly 1620 1625 1630 Ala Gly Gly Tyr Arg Cys
Thr Ala Cys Glu Pro Gly Tyr Thr Gly Gln 1635 1640 1645 Tyr Cys Glu
Gln Cys Gly Pro Gly Tyr Val Gly Asn Pro Ser Val Gln 1650 1655 1660
Gly Gly Gln Cys Leu Pro Glu Thr Asn Gln Ala Pro Leu Val Val Glu
1665 1670 1675 1680 Val His Pro Ala Arg Ser Ile Val Pro Gln Gly Gly
Ser His Ser Leu 1685 1690 1695 Arg Cys Gln Val Ser Gly Ser Pro Pro
His Tyr Phe Tyr Trp Ser Arg 1700 1705 1710 Glu Asp Gly Arg Pro Val
Pro Ser Gly Thr Gln Gln Arg His Gln Gly 1715 1720 1725 Ser Glu Leu
His Phe Pro Ser Val Gln Pro Ser Asp Ala Gly Val Tyr 1730 1735 1740
Ile Cys Thr Cys Arg Asn Leu His Gln Ser Asn Thr Ser Arg Ala Glu
1745 1750 1755 1760 Leu Leu Val Thr Glu Ala Pro Ser Lys Pro Ile Thr
Val Thr Val Glu 1765 1770 1775 Glu Gln Arg Ser Gln Ser Val Arg Pro
Gly Ala Asp Val Thr Phe Ile 1780 1785 1790 Cys Thr Ala Lys Ser Lys
Ser Pro Ala Tyr Thr Leu Val Trp Thr Arg 1795 1800 1805 Leu His Asn
Gly Lys Leu Pro Thr Arg Ala Met Asp Phe Asn Gly Ile 1810 1815 1820
Leu Thr Ile Arg Asn Val Gln Leu Ser Asp Ala Gly Thr Tyr Val Cys
1825 1830 1835 1840 Thr Gly Ser Asn Met Phe Ala Met Asp Gln Gly Thr
Ala Thr Leu His 1845 1850 1855 Val Gln Ala Ser Gly Thr Leu Ser Ala
Pro Val Val Ser Ile His Pro 1860 1865 1870 Pro Gln Leu Thr Val Gln
Pro Gly Gln Leu Ala Glu Phe Arg Cys Ser 1875 1880 1885 Ala Thr Gly
Ser Pro Thr Pro Thr Leu Glu Trp Thr Gly Gly Pro Gly 1890 1895 1900
Gly Gln Leu Pro Ala Lys Ala Gln Ile His Gly Gly Ile Leu Arg Leu
1905 1910 1915 1920 Pro Ala Val Glu Pro Thr Asp Gln Ala Gln Tyr Leu
Cys Arg Ala His 1925 1930 1935 Ser Ser Ala Gly Gln Gln Val Ala Arg
Ala Val Leu His Val His Gly 1940 1945 1950 Gly Gly Gly Pro Arg Val
Gln Val Ser Pro Glu Arg Thr Gln Val His 1955 1960 1965 Ala Gly Arg
Thr Val Arg Leu Tyr Cys Arg Ala Ala Gly Val Pro Ser 1970 1975 1980
Ala Thr Ile Thr Trp Arg Lys Glu Gly Gly Ser Leu Pro Pro Gln Ala
1985 1990 1995 2000 Arg Ser Glu Arg Thr Asp Ile Ala Thr Leu Leu Ile
Pro Ala Ile Thr 2005 2010 2015 Thr Ala Asp Ala Gly Phe Tyr Leu Cys
Val Ala Thr Ser Pro Ala Gly 2020 2025 2030 Thr Ala Gln Ala Arg Ile
Gln Val Val Val Leu Ser Ala Ser Asp Ala 2035 2040 2045 Ser Pro Pro
Pro Val Lys Ile Glu Ser Ser Ser Pro Ser Val Thr Glu 2050 2055 2060
Gly Gln Thr Leu Asp Leu Asn Cys Val Val Ala Gly Ser Ala His Ala
2065 2070 2075 2080 Gln Val Thr Trp Tyr Arg Arg Gly Gly Ser Leu Pro
Pro His Thr Gln 2085 2090 2095 Val His Gly Ser Arg Leu Arg Leu Pro
Gln Val Ser Pro Ala Asp Ser 2100 2105 2110 Gly Glu Tyr Val Cys Arg
Val Glu Asn Gly Ser Gly Pro Lys Glu Ala 2115 2120 2125 Ser Ile Thr
Val Ser Val Leu His Gly Thr His Ser Gly Pro Ser Tyr 2130 2135 2140
Thr Pro Val Pro Gly Ser Thr Arg Pro Ile Arg Ile Glu Pro Ser Ser
2145 2150 2155 2160 Ser His Val Ala Glu Gly Gln Thr Leu Asp Leu Asn
Cys Val Val Pro 2165 2170 2175 Gly Gln Ala His Ala Gln Val Thr Trp
His Lys Arg Gly Gly Ser Leu 2180 2185 2190 Pro Ala Arg His Gln Thr
His Gly Ser Leu Leu Arg Leu His Gln Val 2195 2200 2205 Thr Pro Ala
Asp Ser Gly Glu Tyr Val Cys His Val Val Gly Thr Ser 2210 2215 2220
Gly Pro Leu Glu Ala Ser Val Leu Val Thr Ile Glu Ala Ser Val Ile
2225 2230 2235 2240 Pro Gly Pro Ile Pro Pro Val Arg Ile Glu Ser Ser
Ser Ser Thr Val 2245 2250 2255 Ala Glu Gly Gln Thr Leu Asp Leu Ser
Cys Val Val Ala Gly Gln Ala 2260 2265 2270 His Ala Gln Val Thr Trp
Tyr Lys Arg Gly Gly Ser Leu Pro Ala Arg 2275 2280 2285 His Gln Val
Arg Gly Ser Arg Leu Tyr Ile Phe Gln Ala Ser Pro Ala 2290 2295 2300
Asp Ala Gly Gln Tyr Val Cys Arg Ala Ser Asn Gly Met Glu Ala Ser
2305 2310 2315 2320 Ile Thr Val Thr Val Thr Gly Thr Gln Gly Ala Asn
Leu Ala Tyr Pro 2325 2330 2335 Ala Gly Ser Thr Gln Pro Ile Arg Ile
Glu Pro Ser Ser Ser Gln Val 2340 2345 2350 Ala Glu Gly Gln Thr Leu
Asp Leu Asn Cys Val Val Pro Gly Gln Ser 2355 2360 2365 His Ala Gln
Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Val Arg 2370 2375 2380
His Gln Thr His Gly Ser Leu Leu Arg Leu Tyr Gln Ala Ser Pro Ala
2385 2390 2395 2400 Asp Ser Gly Glu Tyr Val Cys Arg Val Leu Gly Ser
Ser Val Pro Leu 2405 2410 2415 Glu Ala Ser Val Leu Val Thr Ile Glu
Pro Ala Gly Ser Val Pro Ala 2420 2425 2430 Leu Gly Val Thr Pro Thr
Val Arg Ile Glu Ser Ser Ser Ser Gln Val 2435 2440 2445 Ala Glu Gly
Gln Thr Leu Asp Leu Asn Cys Leu Val Ala Gly Gln Ala 2450 2455 2460
His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Ala Arg
2465 2470 2475 2480 His Gln Val His Gly Ser Arg Leu Arg Leu Leu Gln
Val Thr Pro Ala 2485 2490 2495 Asp Ser Gly Glu Tyr Val Cys Arg Val
Val Gly Ser Ser Gly Thr Gln 2500 2505 2510 Glu Ala Ser Val Leu Val
Thr Ile Gln Gln Arg Leu Ser Gly Ser His 2515 2520 2525 Ser Gln Gly
Val Ala Tyr Pro Val Arg Ile Glu Ser Ser Ser Ala Ser 2530 2535 2540
Leu Ala Asn Gly His Thr Leu Asp Leu Asn Cys Leu Val Ala Ser Gln
2545 2550 2555 2560 Ala Pro His Thr Ile Thr Trp Tyr Lys Arg Gly Gly
Ser Leu Pro Ser 2565 2570 2575 Arg His Gln Ile Val Gly Ser Arg Leu
Arg Ile Pro Gln Val Thr Pro 2580 2585 2590 Ala Asp Ser Gly Glu Tyr
Val Cys His Val Ser Asn Gly Ala Gly Ser 2595 2600 2605 Arg Glu Thr
Ser Leu Ile Val Thr Ile Gln Gly Ser Gly Ser Ser His 2610 2615 2620
Val Pro Ser Val Ser Pro Pro Ile Arg Ile Glu Ser Ser Ser Pro Thr
2625 2630 2635 2640 Val Val Glu Gly Gln Thr Leu Asp Leu Asn Cys Val
Val Ala Arg Gln 2645 2650 2655 Pro Gln Ala Ile Ile Thr Trp Tyr Lys
Arg Gly Gly Ser Leu Pro Ser 2660 2665 2670 Arg His Gln Thr His Gly
Ser His Leu Arg Leu His Gln Met Ser Val 2675 2680 2685 Ala Asp Ser
Gly Glu Tyr Val Cys Arg Ala Asn Asn Asn Ile Asp Ala 2690 2695 2700
Leu Glu Ala Ser Ile Val Ile Ser Val Ser Pro Ser Ala Gly Ser Pro
2705 2710 2715 2720 Ser Ala Pro Gly Ser Ser Met Pro Ile Arg Ile Glu
Ser Ser Ser Ser 2725 2730 2735 His Val Ala Glu Gly Glu Thr Leu Asp
Leu Asn Cys Val Val Pro Gly 2740 2745 2750 Gln Ala His Ala Gln Val
Thr Trp His Lys Arg Gly Gly Ser Leu Pro 2755 2760 2765 Ser His His
Gln Thr Arg Gly Ser Arg Leu Arg Leu His His Val Ser 2770 2775 2780
Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg Val Met Gly Ser Ser Gly
2785 2790 2795 2800 Pro Leu Glu Ala Ser Val Leu Val Thr Ile Glu Ala
Ser Gly Ser Ser 2805 2810 2815 Ala Val His Val Pro Ala Pro Gly Gly
Ala Pro Pro Ile Arg Ile Glu 2820 2825 2830 Pro Ser Ser Ser Arg Val
Ala Glu Gly Gln Thr Leu Asp Leu Lys Cys 2835 2840 2845 Val Val Pro
Gly Gln Ala His Ala Gln Val Thr Trp His Lys Arg Gly 2850 2855 2860
Gly Asn Leu Pro Ala Arg His Gln Val His Gly Pro Leu Leu Arg Leu
2865 2870 2875 2880 Asn Gln Val Ser Pro Ala Asp Ser Gly Glu Tyr Ser
Cys Gln Val Thr 2885 2890 2895 Gly Ser Ser Gly Thr Leu Glu Ala Ser
Val Leu Val Thr Ile Glu Pro 2900 2905 2910 Ser Ser Pro Gly Pro Ile
Pro Ala Pro Gly Leu Ala Gln Pro Ile Tyr 2915 2920 2925 Ile Glu Ala
Ser Ser Ser His Val Thr Glu Gly Gln Thr Leu Asp Leu 2930 2935 2940
Asn Cys Val Val Pro Gly Gln Ala His Ala Gln Val Thr Trp Tyr Lys
2945 2950 2955 2960 Arg Gly Gly Ser Leu Pro Ala Arg His Gln Thr His
Gly Ser Gln Leu 2965 2970 2975 Arg Leu His Leu Val Ser Pro Ala Asp
Ser Gly Glu Tyr Val Cys Arg 2980 2985 2990 Ala Ala Ser Gly Pro Gly
Pro Glu Gln Glu Ala Ser Phe Thr Val Thr 2995 3000 3005 Val Pro Pro
Ser Glu Gly Ser Ser Tyr Arg Leu Arg Ser Pro Val Ile 3010 3015 3020
Ser Ile Asp Pro Pro Ser Ser Thr Val Gln Gln Gly Gln Asp Ala Ser
3025 3030 3035 3040 Phe Lys Cys Leu Ile His Asp Gly Ala Ala Pro Ile
Ser Leu Glu Trp 3045 3050 3055 Lys Thr Arg Asn Gln Glu Leu Glu Asp
Asn Val His Ile Ser Pro Asn 3060 3065 3070 Gly Ser Ile Ile Thr Ile
Val Gly Thr Arg Pro Ser Asn His Gly Thr 3075 3080 3085 Tyr Arg Cys
Val Ala Ser Asn Ala Tyr Gly Val Ala Gln Ser Val Val 3090 3095 3100
Asn Leu Ser Val His Gly Pro Pro Thr Val Ser Val Leu Pro Glu Gly
3105 3110 3115 3120 Pro Val Trp Val Lys Val Gly Lys Ala Val Thr Leu
Glu Cys Val Ser 3125 3130 3135 Ala Gly Glu Pro Arg Ser Ser Ala Arg
Trp Thr Arg Ile Ser Ser Thr 3140 3145 3150 Pro Ala Lys Leu Glu Gln
Arg Thr Tyr Gly Leu Met Asp Ser His Ala 3155 3160 3165 Val Leu Gln
Ile Ser Ser Ala Lys Pro Ser Asp Ala Gly Thr Tyr Val 3170 3175 3180
Cys Leu Ala Gln Asn Ala Leu Gly Thr Ala Gln Lys Gln Val Glu Val
3185 3190 3195 3200 Ile Val Asp Thr Gly Ala Met Ala Pro Gly Ala Pro
Gln Val Gln Ala 3205 3210 3215 Glu Glu Ala Glu Leu Thr Val Glu Ala
Gly His Thr Ala Thr Leu Arg 3220 3225 3230 Cys Ser Ala Thr Gly Ser
Pro Ala Pro Thr Ile His Trp Ser Lys Leu 3235 3240 3245 Arg Ser Pro
Leu Pro Trp Gln His Arg Leu Glu Gly Asp Thr Leu Ile 3250 3255 3260
Ile Pro Arg Val Ala Gln Gln Asp Ser Gly Gln Tyr Ile Cys Asn Ala
3265 3270 3275 3280 Thr Ser Pro Ala Gly His Ala Glu Ala Thr Ile Ile
Leu His Val Glu 3285 3290 3295 Ser Pro Pro Tyr Ala Thr Thr Val Pro
Glu His Ala Ser Val Gln Ala 3300 3305 3310 Gly Glu Thr Val Gln Leu
Gln Cys Leu Ala His Gly Thr Pro Pro Leu 3315 3320 3325 Thr Phe Gln
Trp Ser Arg Val Gly Ser Ser Leu Pro Gly Arg Ala Thr 3330 3335 3340
Ala Arg Asn Glu Leu Leu His Phe Glu Arg Ala Ala Pro Glu Asp Ser
3345 3350 3355 3360 Gly Arg Tyr Arg Cys Arg Val Thr Asn Lys Val Gly
Ser Ala Glu Ala 3365 3370 3375 Phe Ala Gln Leu Leu Val Gln Gly Pro
Pro Gly Ser Leu Pro Ala Thr 3380 3385 3390 Ser Ile Pro Ala Gly Ser
Thr Pro Thr Val Gln Val Thr Pro Gln Leu 3395 3400 3405 Glu Thr Lys
Ser Ile Gly Ala Ser Val Glu Phe His Cys Ala Val Pro 3410 3415 3420
Ser Asp Arg Gly Thr Gln Leu Arg Trp Phe Lys Glu Gly Gly Gln Leu
3425 3430 3435 3440 Pro Pro Gly His Ser Val Gln Asp Gly Val Leu Arg
Ile Gln Asn Leu 3445 3450 3455 Asp Gln Ser Cys Gln Gly Thr Tyr Ile
Cys Gln Ala His Gly Pro Trp 3460 3465 3470 Gly Lys Ala Gln Ala Ser
Ala Gln Leu Val Ile Gln Ala Leu Pro Ser 3475 3480 3485 Val Leu Ile
Asn Ile Arg Thr Ser Val Gln Thr Val Val Val Gly His 3490 3495 3500
Ala Val Glu Phe Glu Cys Leu Ala Leu Gly Asp Pro Lys Pro Gln Val
3505 3510 3515 3520 Thr Trp Ser Lys Val Gly Gly His Leu Arg Pro Gly
Ile Val Gln Ser 3525 3530 3535 Gly Gly Val Val Arg Ile Ala His Val
Glu Leu Ala Asp Ala Gly Gln 3540 3545 3550 Tyr Arg Cys Thr Ala Thr
Asn Ala Ala Gly Thr Thr Gln Ser His Val 3555 3560 3565 Leu Leu Leu
Val Gln Ala Leu Pro Gln Ile Ser Met Pro Gln Glu Val 3570 3575 3580
Arg Val Pro Ala Gly Ser Ala Ala Val Phe Pro Cys Ile Ala Ser Gly
3585 3590 3595 3600 Tyr Pro Thr Pro Asp Ile Ser Trp Ser Lys Leu Asp
Gly Ser Leu Pro 3605 3610 3615 Pro Asp Ser Arg Leu Glu Asn Asn Met
Leu Met Leu Pro Ser Val Arg 3620 3625 3630 Pro Gln Asp Ala Gly Thr
Tyr Val Cys Thr Ala Thr Asn Arg Gln Gly 3635 3640 3645 Lys Val Lys
Ala Phe Ala His Leu Gln Val Pro Glu Arg Val Val Pro 3650 3655 3660
Tyr Phe Thr Gln Thr Pro Tyr Ser Phe Leu Pro Leu Pro Thr Ile Lys
3665 3670 3675 3680 Asp Ala Tyr Arg Lys Phe Glu Ile Lys Ile Thr Phe
Arg Pro Asp Ser 3685 3690 3695 Ala Asp Gly Met Leu Leu Tyr Asn Gly
Gln Lys Arg Val Pro Gly Ser 3700 3705 3710 Pro Thr Asn Leu Ala Asn
Arg Gln Pro Asp Phe Ile Ser Phe Gly Leu 3715 3720 3725 Val Gly Gly
Arg Pro Glu Phe Arg Phe Asp Ala Gly Ser Gly Met Ala 3730 3735 3740
Thr Ile Arg His Pro Thr Pro Leu Ala Leu Gly His Phe His Thr Val
3745 3750 3755 3760 Thr Leu Leu Arg Ser Leu Thr Gln Gly Ser Leu Ile
Val Gly Asp Leu 3765 3770 3775 Ala Pro Val Asn Gly Thr Ser Gln Gly
Lys Phe Gln Gly Leu Asp Leu 3780 3785 3790 Asn Glu Glu Leu Tyr Leu
Gly Gly Tyr Pro Asp Tyr Gly Ala Ile Pro 3795 3800 3805 Lys Ala Gly
Leu Ser Ser Gly Phe Ile Gly Cys Val Arg Glu Leu Arg 3810 3815 3820
Ile Gln Gly Glu Glu Ile Val Phe His Asp Leu Asn Leu Thr Ala His
3825 3830 3835 3840 Gly Ile Ser His Cys Pro Thr Cys Arg Asp Arg Pro
Cys Gln Asn Gly 3845 3850 3855 Gly Gln Cys His Asp Ser Glu Ser Ser
Ser Tyr Val Cys Val Cys Pro 3860 3865 3870 Ala Gly Phe Thr Gly Ser
Arg Cys Glu His Ser Gln Ala Leu His Cys 3875 3880 3885 His Pro Glu
Ala Cys Gly Pro Asp Ala Thr Cys Val Asn Arg Pro Asp 3890 3895 3900
Gly Arg Gly Tyr Thr Cys Arg Cys His Leu Gly Arg Ser Gly Leu Arg
3905 3910 3915 3920 Cys Glu Glu Gly Val Thr Val Thr Thr Pro Ser Leu
Ser Gly Ala Gly 3925 3930 3935 Ser Tyr Leu Ala Leu Pro Ala Leu Thr
Asn Thr His His Glu Leu Arg 3940 3945 3950 Leu Asp Val Glu Phe Lys
Pro Leu Ala Pro Asp Gly Val Leu Leu Phe 3955 3960 3965 Ser Gly Gly
Lys Ser Gly Pro Val Glu Asp Phe Val Ser Leu Ala Met 3970 3975 3980
Val Gly Gly His Leu Glu Phe Arg Tyr Glu Leu Gly Ser Gly Leu Ala
3985 3990 3995 4000 Val Leu Arg Ser Ala Glu Pro Leu Ala Leu Gly Arg
Trp His Arg Val 4005 4010 4015 Ser Ala Glu Arg Leu Asn Lys Asp Gly
Ser Leu Arg Val Asn Gly Gly 4020 4025 4030 Arg Pro Val Leu Arg Ser
Ser Pro Gly Lys Ser Gln Gly Leu Asn Leu 4035 4040 4045 His Thr Leu
Leu Tyr Leu Gly Gly Val Glu Pro Ser Val Pro Leu Ser 4050 4055 4060
Pro Ala Thr Asn Met Ser Ala His Phe Arg Gly Cys Val Gly Glu Val
4065 4070 4075 4080 Ser Val Asn Gly Lys Arg Leu Asp Leu Thr Tyr Ser
Phe Leu Gly Ser 4085 4090 4095 Gln Gly Ile Gly Gln Cys Tyr Asp Ser
Ser Pro Cys Glu Arg Gln Pro 4100 4105 4110 Cys Gln His Gly Ala Thr
Cys Met Pro Ala Gly Glu Tyr Glu Phe Gln 4115 4120 4125 Cys Leu Cys
Arg Asp Gly Phe Lys Gly Asp Leu Cys Glu His Glu Glu 4130 4135 4140
Asn Pro Cys Gln Leu Arg Glu Pro Cys Leu His Gly Gly Thr Cys Gln
4145 4150 4155 4160 Gly Thr Arg Cys Leu Cys Leu Pro Gly Phe Ser Gly
Pro Arg Cys Gln 4165 4170 4175 Gln Gly Ser Gly His Gly Ile Ala Glu
Ser Asp Trp His Leu Glu Gly 4180 4185 4190 Ser Gly Gly Asn Asp Ala
Pro Gly Gln Tyr Gly Ala Tyr Phe His Asp 4195 4200 4205 Asp Gly Phe
Leu Ala Phe Pro Gly His Val Phe Ser Arg Ser Leu Pro 4210 4215 4220
Glu Val Pro Glu Thr Ile Glu Leu Glu Val Arg Thr Ser Thr Ala Ser
4225 4230 4235 4240 Gly Leu Leu Leu Trp Gln Gly Val Glu Val Gly Glu
Ala Gly Gln Gly 4245 4250 4255 Lys Asp Phe Ile Ser Leu Gly Leu Gln
Asp Gly His Leu Val Phe Arg 4260 4265 4270 Tyr Gln Leu Gly Ser Gly
Glu Ala Arg Leu Val Ser Glu Asp Pro Ile 4275 4280 4285 Asn Asp Gly
Glu Trp His Arg Val Thr Ala Leu Arg Glu Gly Arg Arg 4290 4295 4300
Gly Ser Ile Gln Val Asp Gly Glu Glu Leu Val Ser Gly Arg Ser Pro
4305 4310 4315 4320 Gly Pro Asn Val Ala Val Asn Ala Lys Gly Ser Val
Tyr Ile Gly Gly 4325 4330 4335 Ala Pro Asp Val Ala Thr Leu Thr Gly
Gly Arg Phe Ser Ser Gly Ile 4340 4345 4350 Thr Gly Cys Val Lys Asn
Leu Val Leu His Ser Ala Arg Pro Gly Ala 4355 4360 4365 Pro Pro Pro
Gln Pro Leu Asp Leu Gln His Arg Ala Gln Ala Gly Ala 4370 4375 4380
Asn Thr Arg Pro Cys Pro Ser 4385 4390 <210> SEQ ID NO 90
<211> LENGTH: 198 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 90 Met Asp Ser Leu Leu Met Asn
Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10 15 Asn Val Arg Trp Ala
Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 20 25 30 Val Lys Arg
Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 35 40 45 Leu
Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 50 55
60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp
65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val
Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile
Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu
Pro Glu Gly Leu Arg Arg 115 120 125 Leu His Arg Ala Gly Val Gln Ile
Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140 Phe Tyr Cys Trp Asn Thr
Phe Val Glu Asn His Glu Arg Thr Phe Lys 145 150 155 160 Ala Trp Glu
Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 165 170 175 Arg
Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 180 185
190 Phe Arg Thr Leu Gly Leu 195 <210> SEQ ID NO 91
<211> LENGTH: 491 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 91 Met Glu Leu Ser Val Leu Leu
Phe Leu Ala Leu Leu Thr Gly Leu Leu 1 5 10 15 Leu Leu Leu Val Gln
Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 20 25 30 Gly Pro Arg
Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 35 40 45 Arg
Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 50 55
60 Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly
65 70 75 80 Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala
Phe Ser 85 90 95 Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe
Arg Gly Tyr Gly 100 105 110 Val Ile Phe Ala Asn Gly Asn Arg Trp Lys
Val Leu Arg Arg Phe Ser 115 120 125 Val Thr Thr Met Arg Asp Phe Gly
Met Gly Lys Arg Ser Val Glu Glu 130 135 140 Arg Ile Gln Glu Glu Ala
Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 145 150 155 160 Lys Gly Ala
Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 165 170 175 Asn
Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 180 185
190 Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu
195 200 205 Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly
Phe Leu 210 215 220 Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys
Asn Leu Gln Glu 225 230 235 240 Ile Asn Ala Tyr Ile Gly His Ser Val
Glu Lys His Arg Glu Thr Leu 245 250 255 Asp Pro Ser Ala Pro Lys Asp
Leu Ile Asp Thr Tyr Leu Leu His Met 260 265 270 Glu Lys Glu Lys Ser
Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 275 280 285 Asn Leu Asn
Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 290 295 300 Thr
Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 305 310
315 320 Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His
Arg 325 330 335 Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr
Glu Ala Val 340 345 350 Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu
Pro Met Gly Val Pro 355 360 365 His Ile Val Thr Gln His Thr Ser Phe
Arg Gly Tyr Ile Ile Pro Lys 370 375 380 Asp Thr Glu Val Phe Leu Ile
Leu Ser Thr Ala Leu His Asp Pro His 385 390 395 400 Tyr Phe Glu Lys
Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 405 410 415 Asn Gly
Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 420 425 430
Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 435
440 445 Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val
Ala 450 455 460 Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val
Gly Lys Ile 465 470 475 480 Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro
Arg 485 490 <210> SEQ ID NO 92 <211> LENGTH: 454
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 92 Met Asp Phe Phe Arg Val Val Glu Asn Gln
Gln Pro Pro Ala Thr Met 1 5 10 15 Pro Leu Asn Val Ser Phe Thr Asn
Arg Asn Tyr Asp Leu Asp Tyr Asp 20 25 30 Ser Val Gln Pro Tyr Phe
Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 35 40 45 Gln Gln Gln Gln
Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 50 55 60 Trp Lys
Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 65 70 75 80
Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 85
90 95 Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
Asp 100 105 110 Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met
Val Asn Gln 115 120 125 Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe
Ile Lys Asn Ile Ile 130 135 140 Ile Gln Asp Cys Met Trp Ser Gly Phe
Ser Ala Ala Ala Lys Leu Val 145 150 155 160 Ser Glu Lys Leu Ala Ser
Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 165 170 175 Pro Asn Pro Ala
Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 180 185 190 Leu Gln
Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 195 200 205
Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 210
215 220 Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
Ser 225 230 235 240 Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro
Leu Val Leu His 245 250 255 Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp
Ser Glu Glu Glu Gln Glu 260 265 270 Asp Glu Glu Glu Ile Asp Val Val
Ser Val Glu Lys Arg Gln Ala Pro 275 280 285 Gly Lys Arg Ser Glu Ser
Gly Ser Pro Ser Ala Gly Gly His Ser Lys 290 295 300 Pro Pro His Ser
Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 305 310 315 320 Gln
His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 325 330
335 Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser
340 345 350 Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu
Glu Asn 355 360 365 Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln
Arg Arg Asn Glu 370 375 380 Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp
Gln Ile Pro Glu Leu Glu 385 390 395 400 Asn Asn Glu Lys Ala Pro Lys
Val Val Ile Leu Lys Lys Ala Thr Ala 405 410 415 Tyr Ile Leu Ser Val
Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 420 425 430 Asp Leu Leu
Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 435 440 445 Leu
Arg Asn Ser Cys Ala 450 <210> SEQ ID NO 93 <211>
LENGTH: 894 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 93 Met Ile Leu Leu Ala Val Leu Phe
Leu Cys Phe Ile Ser Ser Tyr Ser 1 5 10 15 Ala Ser Val Lys Gly His
Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 20 25 30 Leu Tyr Lys Leu
Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 35 40 45 Gly Lys
Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 50 55 60
Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 65
70 75 80 Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln
Gln Arg 85 90 95 Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser
Lys Ile Met Gly 100 105 110 Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro
Thr Leu Leu His Leu Ile 115 120 125 His Gly Lys Val Lys Glu Phe Tyr
Ser Tyr Gln Asn Glu Ala Val Ala 130 135 140 Ile Glu Asn Ile Lys Arg
Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 145 150 155 160 Ser Ser Gly
Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 165 170 175 Thr
Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 180 185
190 Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu
195 200 205 Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile
Glu Asp 210 215 220 Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His
Asn Phe Gly Leu 225 230 235 240 Asn Phe Leu Gln Thr Ile Lys Gly Lys
Ile Val Ser Lys Gln Lys Leu 245 250 255 Glu Leu Lys Thr Thr Glu Ala
Gly Pro Arg Leu Met Ser Gly Lys Gln 260 265 270 Ala Ala Ala Ile Ile
Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 275 280 285 Ile Val Gly
Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 290 295 300 Ser
Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 305 310
315 320 Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His
Leu 325 330 335 Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys
Met Glu Asn 340 345 350 Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val
Thr Ser Ala Gln Thr 355 360 365 Ser Asp Ser Leu Glu Ala Ile Leu Asp
Phe Leu Asp Phe Lys Ser Asp 370 375 380 Ser Ser Ile Ile Leu Gln Glu
Arg Phe Leu Tyr Ala Cys Gly Phe Ala 385 390 395 400 Ser His Pro Asn
Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 405 410 415 Gly Ser
Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 420 425 430
Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 435
440 445 Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys
Ala 450 455 460 Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu
Lys Asn Ala 465 470 475 480 Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu
Lys Tyr Ala Glu Ala Gly 485 490 495 Glu Gly Pro Ile Ser His Leu Ala
Thr Thr Ala Leu Gln Arg Tyr Asp 500 505 510 Leu Pro Phe Ile Thr Asp
Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr 515 520 525 His Gln Asn Arg
Lys Val His Glu Lys Thr Val Arg Thr Ala Ala Ala 530 535 540 Ala Ile
Ile Leu Asn Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile 545 550 555
560 Leu Leu Ser Ile Gly Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu
565 570 575 Ala Ile Val Gln Asp Ile Leu Arg Phe Glu Met Pro Ala Ser
Lys Ile 580 585 590 Val Arg Arg Val Leu Lys Glu Met Val Ala His Asn
Tyr Asp Arg Phe 595 600 605 Ser Arg Ser Gly Ser Ser Ser Ala Tyr Thr
Gly Tyr Ile Glu Arg Ser 610 615 620 Pro Arg Ser Ala Ser Thr Tyr Ser
Leu Asp Ile Leu Tyr Ser Gly Ser 625 630 635 640 Gly Ile Leu Arg Arg
Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys 645 650 655 Ala Gly Leu
His Gly Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu 660 665 670 Ala
Leu Ile Ala Ala Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser 675 680
685 Tyr Ala Gly Met Ser Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val
690 695 700 Thr Phe Phe Asn Gly Tyr Ser Asp Leu Met Ser Lys Met Leu
Ser Ala 705 710 715 720 Ser Gly Asp Pro Ile Ser Val Val Lys Gly Leu
Ile Leu Leu Ile Asp 725 730 735 His Ser Gln Glu Leu Gln Leu Gln Ser
Gly Leu Lys Ala Asn Ile Glu 740 745 750 Val Gln Gly Gly Leu Ala Ile
Asp Ile Ser Gly Ala Met Glu Phe Ser 755 760 765 Leu Trp Tyr Arg Glu
Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val 770 775 780 Val Ile Thr
Thr Asp Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly 785 790 795 800
Leu Glu Thr Ser Thr Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr 805
810 815 Val Gln Phe Ser Gln Tyr Pro Phe Leu Val Cys Met Gln Met Asp
Lys 820 825 830 Asp Glu Ala Pro Phe Arg Gln Phe Glu Lys Lys Tyr Glu
Arg Leu Ser 835 840 845 Thr Gly Arg Gly Tyr Val Ser Gln Lys Arg Lys
Glu Ser Val Leu Ala 850 855 860 Gly Cys Glu Phe Pro Leu His Gln Glu
Asn Ser Glu Met Cys Lys Val 865 870 875 880 Val Phe Ala Pro Gln Pro
Asp Ser Thr Ser Ser Gly Trp Phe 885 890 <210> SEQ ID NO 94
<211> LENGTH: 1210 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 94 Met Arg Pro Ser Gly
Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 1 5 10 15 Ala Leu Cys
Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 20 25 30 Gly
Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 35 40
45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe
Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala
Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile
Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu Asn Ser Tyr Ala Leu Ala
Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125 Lys Thr Gly Leu Lys Glu
Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130 135 140 His Gly Ala Val
Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 145 150 155 160 Ser
Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 165 170
175 Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn
Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser
Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro Ser Asp Cys Cys His Asn
Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr Gly Pro Arg Glu Ser Asp
Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250 255 Glu Ala Thr Cys Lys
Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 260 265 270 Thr Thr Tyr
Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 275 280 285 Ala
Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 290 295
300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305 310 315 320 Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys
Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn Ile Lys His Phe Lys Asn
Cys Thr Ser Ile Ser Gly Asp 355 360 365 Leu His Ile Leu Pro Val Ala
Phe Arg Gly Asp Ser Phe Thr His Thr 370 375 380 Pro Pro Leu Asp Pro
Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 385 390 395 400 Ile Thr
Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 405 410 415
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 420
425 430 His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser
Leu 435 440 445 Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
Ile Ile Ser 450 455 460 Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile
Asn Trp Lys Lys Leu 465 470 475 480 Phe Gly Thr Ser Gly Gln Lys Thr
Lys Ile Ile Ser Asn Arg Gly Glu 485 490 495 Asn Ser Cys Lys Ala Thr
Gly Gln Val Cys His Ala Leu Cys Ser Pro 500 505 510 Glu Gly Cys Trp
Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 515 520 525 Val Ser
Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 530 535 540
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 545
550 555 560 Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg
Gly Pro 565 570 575 Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly
Pro His Cys Val 580 585 590 Lys Thr Cys Pro Ala Gly Val Met Gly Glu
Asn Asn Thr Leu Val Trp 595 600 605 Lys Tyr Ala Asp Ala Gly His Val
Cys His Leu Cys His Pro Asn Cys 610 615 620 Thr Tyr Gly Cys Thr Gly
Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 625 630 635 640 Pro Lys Ile
Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 645 650 655 Leu
Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 660 665
670 Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
675 680 685 Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala
Leu Leu 690 695 700 Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys
Val Leu Gly Ser 705 710 715 720 Gly Ala Phe Gly Thr Val Tyr Lys Gly
Leu Trp Ile Pro Glu Gly Glu 725 730 735 Lys Val Lys Ile Pro Val Ala
Ile Lys Glu Leu Arg Glu Ala Thr Ser 740 745 750 Pro Lys Ala Asn Lys
Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 755 760 765 Val Asp Asn
Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 770 775 780 Thr
Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 785 790
795 800 Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu
Asn 805 810 815 Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu
Asp Arg Arg 820 825 830 Leu Val His Arg Asp Leu Ala Ala Arg Asn Val
Leu Val Lys Thr Pro 835 840 845 Gln His Val Lys Ile Thr Asp Phe Gly
Leu Ala Lys Leu Leu Gly Ala 850 855 860 Glu Glu Lys Glu Tyr His Ala
Glu Gly Gly Lys Val Pro Ile Lys Trp 865 870 875 880 Met Ala Leu Glu
Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 885 890 895 Val Trp
Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 900 905 910
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 915
920 925 Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val
Tyr 930 935 940 Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser
Arg Pro Lys 945 950 955 960 Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys
Met Ala Arg Asp Pro Gln 965 970 975 Arg Tyr Leu Val Ile Gln Gly Asp
Glu Arg Met His Leu Pro Ser Pro 980 985 990 Thr Asp Ser Asn Phe Tyr
Arg Ala Leu Met Asp Glu Glu Asp Met Asp 995 1000 1005 Asp Val Val
Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe 1010 1015 1020
Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala
1025 1030 1035 1040 Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg
Asn Gly Leu Gln 1045 1050 1055 Ser Cys Pro Ile Lys Glu Asp Ser Phe
Leu Gln Arg Tyr Ser Ser Asp 1060 1065 1070 Pro Thr Gly Ala Leu Thr
Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro 1075 1080 1085 Val Pro Glu
Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 1090 1095 1100
Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser
1105 1110 1115 1120 Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala
Val Gly Asn Pro 1125 1130 1135 Glu Tyr Leu Asn Thr Val Gln Pro Thr
Cys Val Asn Ser Thr Phe Asp 1140 1145 1150 Ser Pro Ala His Trp Ala
Gln Lys Gly Ser His Gln Ile Ser Leu Asp 1155 1160 1165 Asn Pro Asp
Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn 1170 1175 1180
Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val
1185 1190 1195 1200 Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 1205
1210 <210> SEQ ID NO 95 <211> LENGTH: 705 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
95 Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
1 5 10 15 Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val
Cys Gln 20 25 30 Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe
Glu Asp His Phe 35 40 45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys
Glu Val Val Leu Gly Asn 50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg
Asn Tyr Asp Leu Ser Phe Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala
Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro
Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu
Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130
135 140 His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val
Glu 145 150 155 160 Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe
Leu Ser Asn Met 165 170 175 Ser Met Asp Phe Gln Asn His Leu Gly Ser
Cys Gln Lys Cys Asp Pro 180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp
Gly Ala Gly Glu Glu Asn Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile
Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro
Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr
Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250
255 Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
260 265 270 Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser
Phe Gly 275 280 285 Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val
Val Thr Asp His 290 295 300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp
Ser Tyr Glu Met Glu Glu 305 310 315 320 Asp Gly Val Arg Lys Cys Lys
Lys Cys Glu Gly Pro Cys Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly
Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn
Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 355 360 365 Leu
His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 370 375
380 Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385 390 395 400 Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
Arg Thr Asp 405 410 415 Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg
Gly Arg Thr Lys Gln 420 425 430 His Gly Gln Phe Ser Leu Ala Val Val
Ser Leu Asn Ile Thr Ser Leu 435 440 445 Gly Leu Arg Ser Leu Lys Glu
Ile Ser Asp Gly Asp Val Ile Ile Ser 450 455 460 Gly Asn Lys Asn Leu
Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 465 470 475 480 Phe Gly
Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 485 490 495
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 500
505 510 Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg
Asn 515 520 525 Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
Leu Glu Gly 530 535 540 Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys
Ile Gln Cys His Pro 545 550 555 560 Glu Cys Leu Pro Gln Ala Met Asn
Ile Thr Cys Thr Gly Arg Gly Pro 565 570 575 Asp Asn Cys Ile Gln Cys
Ala His Tyr Ile Asp Gly Pro His Cys Val 580 585 590 Lys Thr Cys Pro
Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 595 600 605 Lys Tyr
Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 610 615 620
Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 625
630 635 640 Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val
Ser His 645 650 655 Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu
Gly Trp Ile Pro 660 665 670 Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly
Trp Gly Gly Cys Ser His 675 680 685 Leu His Ala Trp Pro Ser Ala Ser
Val Ile Ile Thr Ala Ser Ser Cys 690 695 700 His 705 <210> SEQ
ID NO 96 <211> LENGTH: 628 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 96 Met Arg Pro Ser Gly
Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 1 5 10 15 Ala Leu Cys
Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 20 25 30 Gly
Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 35 40
45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe
Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala
Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile
Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu Asn Ser Tyr Ala Leu Ala
Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125 Lys Thr Gly Leu Lys Glu
Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130 135 140 His Gly Ala Val
Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 145 150 155 160 Ser
Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 165 170
175 Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn
Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser
Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro Ser Asp Cys Cys His Asn
Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr Gly Pro Arg Glu Ser Asp
Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250 255 Glu Ala Thr Cys Lys
Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 260 265 270 Thr Thr Tyr
Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 275 280 285 Ala
Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 290 295
300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305 310 315 320 Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys
Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn Ile Lys His Phe Lys Asn
Cys Thr Ser Ile Ser Gly Asp 355 360 365 Leu His Ile Leu Pro Val Ala
Phe Arg Gly Asp Ser Phe Thr His Thr 370 375 380 Pro Pro Leu Asp Pro
Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 385 390 395 400 Ile Thr
Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 405 410 415
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 420
425 430 His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser
Leu 435 440 445 Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
Ile Ile Ser 450 455 460 Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile
Asn Trp Lys Lys Leu 465 470 475 480 Phe Gly Thr Ser Gly Gln Lys Thr
Lys Ile Ile Ser Asn Arg Gly Glu 485 490 495 Asn Ser Cys Lys Ala Thr
Gly Gln Val Cys His Ala Leu Cys Ser Pro 500 505 510 Glu Gly Cys Trp
Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 515 520 525 Val Ser
Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 530 535 540
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 545
550 555 560 Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg
Gly Pro 565 570 575 Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly
Pro His Cys Val 580 585 590 Lys Thr Cys Pro Ala Gly Val Met Gly Glu
Asn Asn Thr Leu Val Trp 595 600 605 Lys Tyr Ala Asp Ala Gly His Val
Cys His Leu Cys His Pro Asn Cys 610 615 620 Thr Tyr Gly Ser 625
<210> SEQ ID NO 97 <211> LENGTH: 242 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 97 Met
Ser Gly Cys Asp Ala Arg Glu Gly Asp Cys Cys Ser Arg Arg Cys 1 5 10
15 Gly Ala Gln Asp Lys Glu His Pro Arg Tyr Leu Ile Pro Glu Leu Cys
20 25 30 Lys Gln Phe Tyr His Leu Gly Trp Val Thr Gly Thr Gly Gly
Gly Ile 35 40 45 Ser Leu Lys His Gly Asp Glu Ile Tyr Ile Ala Pro
Ser Gly Val Gln 50 55 60 Lys Glu Arg Ile Gln Pro Glu Asp Met Phe
Val Cys Asp Ile Asn Glu 65 70 75 80 Lys Asp Ile Ser Gly Pro Ser Pro
Ser Lys Lys Leu Lys Lys Ser Gln 85 90 95 Cys Thr Pro Leu Phe Met
Asn Ala Tyr Thr Met Arg Gly Ala Gly Ala 100 105 110 Val Ile His Thr
His Ser Lys Ala Ala Val Met Ala Thr Leu Leu Phe 115 120 125 Pro Gly
Arg Glu Phe Lys Ile Thr His Gln Glu Met Ile Lys Gly Ile 130 135 140
Lys Lys Cys Thr Ser Gly Gly Tyr Tyr Arg Tyr Asp Asp Met Leu Val 145
150 155 160 Val Pro Ile Ile Glu Asn Thr Pro Glu Glu Lys Asp Leu Lys
Asp Arg 165 170 175 Met Ala His Ala Met Asn Glu Tyr Pro Asp Ser Cys
Ala Val Leu Val 180 185 190 Arg Arg His Gly Val Tyr Val Trp Gly Glu
Thr Trp Glu Lys Ala Lys 195 200 205 Thr Met Cys Glu Cys Tyr Asp Tyr
Leu Phe Asp Ile Ala Val Ser Met 210 215 220 Lys Lys Val Gly Leu Asp
Pro Ser Gln Leu Pro Val Gly Glu Asn Gly 225 230 235 240 Ile Val
<210> SEQ ID NO 98 <211> LENGTH: 367 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 98 Met
Arg Trp Phe Leu Pro Trp Thr Leu Ala Ala Val Thr Ala Ala Ala 1 5 10
15 Ala Ser Thr Val Leu Ala Thr Ala Leu Ser Pro Ala Pro Thr Thr Met
20 25 30 Asp Phe Thr Pro Ala Pro Leu Glu Asp Thr Ser Ser Arg Pro
Gln Phe 35 40 45 Cys Lys Trp Pro Cys Glu Cys Pro Pro Ser Pro Pro
Arg Cys Pro Leu 50 55 60 Gly Val Ser Leu Ile Thr Asp Gly Cys Glu
Cys Cys Lys Met Cys Ala 65 70 75 80 Gln Gln Leu Gly Asp Asn Cys Thr
Glu Ala Ala Ile Cys Asp Pro His 85 90 95 Arg Gly Leu Tyr Cys Asp
Tyr Ser Gly Asp Arg Pro Arg Tyr Ala Ile 100 105 110 Gly Val Cys Ala
Gln Val Val Gly Val Gly Cys Val Leu Asp Gly Val 115 120 125 Arg Tyr
Asn Asn Gly Gln Ser Phe Gln Pro Asn Cys Lys Tyr Asn Cys 130 135 140
Thr Cys Ile Asp Gly Ala Val Gly Cys Thr Pro Leu Cys Leu Arg Val 145
150 155 160 Arg Pro Pro Arg Leu Trp Cys Pro His Pro Arg Arg Val Ser
Ile Pro 165 170 175 Gly His Cys Cys Glu Gln Trp Val Cys Glu Asp Asp
Ala Lys Arg Pro 180 185 190 Arg Lys Thr Ala Pro Arg Asp Thr Gly Ala
Phe Asp Ala Val Gly Glu 195 200 205 Val Glu Ala Trp His Arg Asn Cys
Ile Ala Tyr Thr Ser Pro Trp Ser 210 215 220 Pro Cys Ser Thr Ser Cys
Gly Leu Gly Val Ser Thr Arg Ile Ser Asn 225 230 235 240 Val Asn Ala
Gln Cys Trp Pro Glu Gln Glu Ser Arg Leu Cys Asn Leu 245 250 255 Arg
Pro Cys Asp Val Asp Ile His Thr Leu Ile Lys Ala Gly Lys Lys 260 265
270 Cys Leu Ala Val Tyr Gln Pro Glu Ala Ser Met Asn Phe Thr Leu Ala
275 280 285 Gly Cys Ile Ser Thr Arg Ser Tyr Gln Pro Lys Tyr Cys Gly
Val Cys 290 295 300 Met Asp Asn Arg Cys Cys Ile Pro Tyr Lys Ser Lys
Thr Ile Asp Val 305 310 315 320 Ser Phe Gln Cys Pro Asp Gly Leu Gly
Phe Ser Arg Gln Val Leu Trp 325 330 335 Ile Asn Ala Cys Phe Cys Asn
Leu Ser Cys Arg Asn Pro Asn Asp Ile 340 345 350 Phe Ala Asp Leu Glu
Ser Tyr Pro Asp Phe Ser Glu Ile Ala Asn 355 360 365 <210> SEQ
ID NO 99 <211> LENGTH: 280 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 99 Met Arg Trp Phe Leu
Pro Trp Thr Leu Ala Ala Val Thr Ala Ala Ala 1 5 10 15 Ala Ser Thr
Val Leu Ala Thr Ala Leu Ser Pro Ala Pro Thr Thr Met 20 25 30 Asp
Phe Thr Pro Ala Pro Leu Glu Asp Thr Ser Ser Arg Pro Gln Phe 35 40
45 Cys Lys Trp Pro Cys Glu Cys Pro Pro Ser Pro Pro Arg Cys Pro Leu
50 55 60 Gly Val Ser Leu Ile Thr Asp Gly Cys Glu Cys Cys Lys Met
Cys Ala 65 70 75 80 Gln Gln Leu Gly Asp Asn Cys Thr Glu Ala Ala Ile
Cys Asp Pro His 85 90 95 Arg Gly Leu Tyr Cys Asp Tyr Ser Gly Asp
Arg Pro Arg Tyr Ala Ile 100 105 110 Gly Val Cys Ala His Ala Val Gly
Glu Val Glu Ala Trp His Arg Asn 115 120 125 Cys Ile Ala Tyr Thr Ser
Pro Trp Ser Pro Cys Ser Thr Ser Cys Gly 130 135 140 Leu Gly Val Ser
Thr Arg Ile Ser Asn Val Asn Ala Gln Cys Trp Pro 145 150 155 160 Glu
Gln Glu Ser Arg Leu Cys Asn Leu Arg Pro Cys Asp Val Asp Ile 165 170
175 His Thr Leu Ile Lys Ala Gly Lys Lys Cys Leu Ala Val Tyr Gln Pro
180 185 190 Glu Ala Ser Met Asn Phe Thr Leu Ala Gly Cys Ile Ser Thr
Arg Ser 195 200 205 Tyr Gln Pro Lys Tyr Cys Gly Val Cys Met Asp Asn
Arg Cys Cys Ile 210 215 220 Pro Tyr Lys Ser Lys Thr Ile Asp Val Ser
Phe Gln Cys Pro Asp Gly 225 230 235 240 Leu Gly Phe Ser Arg Gln Val
Leu Trp Ile Asn Ala Cys Phe Cys Asn 245 250 255 Leu Ser Cys Arg Asn
Pro Asn Asp Ile Phe Ala Asp Leu Glu Ser Tyr 260 265 270 Pro Asp Phe
Ser Glu Ile Ala Asn 275 280 <210> SEQ ID NO 100 <211>
LENGTH: 370 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 100 Met Gly Leu Trp Ala Leu Leu Pro
Gly Trp Val Ser Ala Thr Leu Leu 1 5 10 15 Leu Ala Leu Ala Ala Leu
Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 20 25 30 Arg Trp Trp Gly
Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 35 40 45 Asp Ser
Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 50 55 60
Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 65
70 75 80 Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys
Trp Gln 85 90 95 Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro
Gly Pro His Leu 100 105 110 Phe Gly Lys Ile Val Asn Arg Gly Cys Arg
Glu Thr Ala Phe Ile Phe 115 120 125 Ala Ile Thr Ser Ala Gly Val Thr
His Ser Val Ala Arg Ser Cys Ser 130 135 140 Glu Gly Ser Ile Glu Ser
Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 145 150 155 160 Gly Gly Pro
Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 165 170 175 Gly
Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 180 185
190 Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr
195 200 205 Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly
Met Ser 210 215 220 Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu
Pro Thr Leu Arg 225 230 235 240 Ala Val Gly Asp Val Leu Arg Asp Arg
Phe Asp Gly Ala Ser Arg Val 245 250 255 Leu Tyr Gly Asn Arg Gly Ser
Asn Arg Ala Ser Arg Ala Glu Leu Leu 260 265 270 Arg Leu Glu Pro Glu
Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 275 280 285 Leu Val Tyr
Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 290 295 300 Leu
Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 305 310
315 320 Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg
Thr 325 330 335 Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe
His Trp Cys 340 345 350 Cys His Val Ser Cys Arg Asn Cys Thr His Thr
Arg Val Leu His Glu 355 360 365 Cys Leu 370 <210> SEQ ID NO
101 <211> LENGTH: 648 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 101 Met Glu His Ile
Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 1 5 10 15 Phe Lys
Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 20 25 30
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 35
40 45 Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro
Asn 50 55 60 Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser
Leu His Asp 65 70 75 80 Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu
Gln Pro Glu Cys Cys 85 90 95 Ala Val Phe Arg Leu Leu His Glu His
Lys Gly Lys Lys Ala Arg Leu 100 105 110 Asp Trp Asn Thr Asp Ala Ala
Ser Leu Ile Gly Glu Glu Leu Gln Val 115 120 125 Asp Phe Leu Asp His
Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 130 135 140 Thr Phe Leu
Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 145 150 155 160
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 165
170 175 Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg
Gln 180 185 190 Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly
Val Pro Ala 195 200 205 Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu
Ser Val Ser Arg Met 210 215 220 Pro Val Ser Ser Gln His Arg Tyr Ser
Thr Pro His Ala Phe Thr Phe 225 230 235 240 Asn Thr Ser Ser Pro Ser
Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 245 250 255 Ser Thr Ser Thr
Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 260 265 270 Asp Ser
Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 275 280 285
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 290
295 300 Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala
Pro 305 310 315 320 Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro
Arg Gly Gln Arg 325 330 335 Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala
Ser Glu Val Met Leu Ser 340 345 350 Thr Arg Ile Gly Ser Gly Ser Phe
Gly Thr Val Tyr Lys Gly Lys Trp 355 360 365 His Gly Asp Val Ala Val
Lys Ile Leu Lys Val Val Asp Pro Thr Pro 370 375 380 Glu Gln Phe Gln
Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 385 390 395 400 Arg
His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 405 410
415 Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His
420 425 430 Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile
Asp Ile 435 440 445 Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His
Ala Lys Asn Ile 450 455 460 Ile His Arg Asp Met Lys Ser Asn Asn Ile
Phe Leu His Glu Gly Leu 465 470 475 480 Thr Val Lys Ile Gly Asp Phe
Gly Leu Ala Thr Val Lys Ser Arg Trp 485 490 495 Ser Gly Ser Gln Gln
Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 500 505 510 Ala Pro Glu
Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 515 520 525 Ser
Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 530 535
540 Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met
545 550 555 560 Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu
Tyr Lys Asn 565 570 575 Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp
Cys Val Lys Lys Val 580 585 590 Lys Glu Glu Arg Pro Leu Phe Pro Gln
Ile Leu Ser Ser Ile Glu Leu 595 600 605 Leu Gln His Ser Leu Pro Lys
Ile Asn Arg Ser Ala Ser Glu Pro Ser 610 615 620 Leu His Arg Ala Ala
His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 625 630 635 640 Thr Ser
Pro Arg Leu Pro Val Phe 645 <210> SEQ ID NO 102 <211>
LENGTH: 536 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 102 Met Gly Ser Asn Lys Ser Lys Pro
Lys Asp Ala Ser Gln Arg Arg Arg 1 5 10 15 Ser Leu Glu Pro Ala Glu
Asn Val His Gly Ala Gly Gly Gly Ala Phe 20 25 30 Pro Ala Ser Gln
Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 35 40 45 Gly Pro
Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 50 55 60
Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 65
70 75 80 Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp
Tyr Glu 85 90 95 Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly
Glu Arg Leu Gln 100 105 110 Ile Val Asn Asn Thr Glu Gly Asp Trp Trp
Leu Ala His Ser Leu Ser 115 120 125 Thr Gly Gln Thr Gly Tyr Ile Pro
Ser Asn Tyr Val Ala Pro Ser Asp 130 135 140 Ser Ile Gln Ala Glu Glu
Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 145 150 155 160 Ser Glu Arg
Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 165 170 175 Val
Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 180 185
190 Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg
195 200 205 Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln
Phe Asn 210 215 220 Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His
Ala Asp Gly Leu 225 230 235 240 Cys His Arg Leu Thr Thr Val Cys Pro
Thr Ser Lys Pro Gln Thr Gln 245 250 255 Gly Leu Ala Lys Asp Ala Trp
Glu Ile Pro Arg Glu Ser Leu Arg Leu 260 265 270 Glu Val Lys Leu Gly
Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 275 280 285 Trp Asn Gly
Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 290 295 300 Met
Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 305 310
315 320 Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu
Pro 325 330 335 Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu
Leu Asp Phe 340 345 350 Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu
Pro Gln Leu Val Asp 355 360 365 Met Ala Ala Gln Ile Ala Ser Gly Met
Ala Tyr Val Glu Arg Met Asn 370 375 380 Tyr Val His Arg Asp Leu Arg
Ala Ala Asn Ile Leu Val Gly Glu Asn 385 390 395 400 Leu Val Cys Lys
Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 405 410 415 Asn Glu
Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 420 425 430
Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 435
440 445 Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg
Val 450 455 460 Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln
Val Glu Arg 465 470 475 480 Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys
Pro Glu Ser Leu His Asp 485 490 495 Leu Met Cys Gln Cys Trp Arg Lys
Glu Pro Glu Glu Arg Pro Thr Phe 500 505 510 Glu Tyr Leu Gln Ala Phe
Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 515 520 525 Gln Tyr Gln Pro
Gly Glu Asn Leu 530 535 <210> SEQ ID NO 103 <211>
LENGTH: 480 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 103 Met Ser Asp Val Ala Ile Val Lys
Glu Gly Trp Leu His Lys Arg Gly 1 5 10 15 Glu Tyr Ile Lys Thr Trp
Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 20 25 30 Gly Thr Phe Ile
Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 35 40 45 Glu Ala
Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 65
70 75 80 Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu
Glu Arg 85 90 95 Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp
Gly Leu Lys Lys 100 105 110 Gln Glu Glu Glu Glu Met Asp Phe Arg Ser
Gly Ser Pro Ser Asp Asn 115 120 125 Ser Gly Ala Glu Glu Met Glu Val
Ser Leu Ala Lys Pro Lys His Arg 130 135 140 Val Thr Met Asn Glu Phe
Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 145 150 155 160 Phe Gly Lys
Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 165 170 175 Ala
Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 180 185
190 Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro
195 200 205 Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg
Leu Cys 210 215 220 Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe
Phe His Leu Ser 225 230 235 240 Arg Glu Arg Val Phe Ser Glu Asp Arg
Ala Arg Phe Tyr Gly Ala Glu 245 250 255 Ile Val Ser Ala Leu Asp Tyr
Leu His Ser Glu Lys Asn Val Val Tyr 260 265 270 Arg Asp Leu Lys Leu
Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 275 280 285 Lys Ile Thr
Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 290 295 300 Thr
Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 305 310
315 320 Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu
Gly 325 330 335 Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe
Tyr Asn Gln 340 345 350 Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met
Glu Glu Ile Arg Phe 355 360 365 Pro Arg Thr Leu Gly Pro Glu Ala Lys
Ser Leu Leu Ser Gly Leu Leu 370 375 380 Lys Lys Asp Pro Lys Gln Arg
Leu Gly Gly Gly Ser Glu Asp Ala Lys 385 390 395 400 Glu Ile Met Gln
His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 405 410 415 Tyr Glu
Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 420 425 430
Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 435
440 445 Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser
Glu 450 455 460 Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser
Gly Thr Ala 465 470 475 480 <210> SEQ ID NO 104 <211>
LENGTH: 379 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 104 Met Ala Ala Ala Ala Ala Gln Gly
Gly Gly Gly Gly Glu Pro Arg Arg 1 5 10 15 Thr Glu Gly Val Gly Pro
Gly Val Pro Gly Glu Val Glu Met Val Lys 20 25 30 Gly Gln Pro Phe
Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 35 40 45 Gly Glu
Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 50 55 60
Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 65
70 75 80 Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg
Phe Arg 85 90 95 His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg
Ala Ser Thr Leu 100 105 110 Glu Ala Met Arg Asp Val Tyr Ile Val Gln
Asp Leu Met Glu Thr Asp 115 120 125 Leu Tyr Lys Leu Leu Lys Ser Gln
Gln Leu Ser Asn Asp His Ile Cys 130 135 140 Tyr Phe Leu Tyr Gln Ile
Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 145 150 155 160 Asn Val Leu
His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 165 170 175 Thr
Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 180 185
190 Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg
195 200 205 Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr
Thr Lys 210 215 220 Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala
Glu Met Leu Ser 225 230 235 240 Asn Arg Pro Ile Phe Pro Gly Lys His
Tyr Leu Asp Gln Leu Asn His 245 250 255 Ile Leu Gly Ile Leu Gly Ser
Pro Ser Gln Glu Asp Leu Asn Cys Ile 260 265 270 Ile Asn Met Lys Ala
Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 275 280 285 Lys Val Ala
Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 290 295 300 Asp
Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 305 310
315 320 Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp
Pro 325 330 335 Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala
Met Glu Leu 340 345 350 Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu
Ile Phe Gln Glu Thr 355 360 365 Ala Arg Phe Gln Pro Gly Val Leu Glu
Ala Pro 370 375 <210> SEQ ID NO 105 <211> LENGTH: 360
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 105 Met Ala Ala Ala Ala Ala Ala Gly Ala Gly
Pro Glu Met Val Arg Gly 1 5 10 15 Gln Val Phe Asp Val Gly Pro Arg
Tyr Thr Asn Leu Ser Tyr Ile Gly 20 25 30 Glu Gly Ala Tyr Gly Met
Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 35 40 45 Val Arg Val Ala
Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 50 55 60 Cys Gln
Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 65 70 75 80
Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 85
90 95 Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp
Leu 100 105 110 Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His
Ile Cys Tyr 115 120 125 Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr
Ile His Ser Ala Asn 130 135 140 Val Leu His Arg Asp Leu Lys Pro Ser
Asn Leu Leu Leu Asn Thr Thr 145 150 155 160 Cys Asp Leu Lys Ile Cys
Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 165 170 175 Asp His Asp His
Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 180 185 190 Tyr Arg
Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 195 200 205
Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 210
215 220 Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His
Ile 225 230 235 240 Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu
Asn Cys Ile Ile 245 250 255 Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser
Leu Pro His Lys Asn Lys 260 265 270 Val Pro Trp Asn Arg Leu Phe Pro
Asn Ala Asp Ser Lys Ala Leu Asp 275 280 285 Leu Leu Asp Lys Met Leu
Thr Phe Asn Pro His Lys Arg Ile Glu Val 290 295 300 Glu Gln Ala Leu
Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 305 310 315 320 Asp
Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 325 330
335 Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala
340 345 350 Arg Phe Gln Pro Gly Tyr Arg Ser 355 360 <210> SEQ
ID NO 106 <211> LENGTH: 239 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 106 Met Ala His Ala
Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 1 5 10 15 Lys Tyr
Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 20 25 30
Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 35
40 45 Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg
Asp 50 55 60 Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala
Pro Gly Ala 65 70 75 80 Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro
Val Val His Leu Thr 85 90 95 Leu Arg Gln Ala Gly Asp Asp Phe Ser
Arg Arg Tyr Arg Arg Asp Phe 100 105 110 Ala Glu Met Ser Ser Gln Leu
His Leu Thr Pro Phe Thr Ala Arg Gly 115 120 125 Arg Phe Ala Thr Val
Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 130 135 140 Gly Arg Ile
Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 145 150 155 160
Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 165
170 175 Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp
Asn 180 185 190 Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser
Met Arg Pro 195 200 205 Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr
Leu Leu Ser Leu Ala 210 215 220 Leu Val Gly Ala Cys Ile Thr Leu Gly
Ala Tyr Leu Gly His Lys 225 230 235 <210> SEQ ID NO 107
<211> LENGTH: 99 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 107 Met Thr Ser Lys Leu Ala Val
Ala Leu Leu Ala Ala Phe Leu Ile Ser 1 5 10 15 Ala Ala Leu Cys Glu
Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 20 25 30 Arg Cys Gln
Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 35 40 45 Ile
Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 50 55
60 Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro
65 70 75 80 Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys
Arg Ala 85 90 95 Glu Asn Ser <210> SEQ ID NO 108 <211>
LENGTH: 107 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 108 Met Ala Arg Ala Ala Leu Ser Ala
Ala Pro Ser Asn Pro Arg Leu Leu 1 5 10 15 Arg Val Ala Leu Leu Leu
Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 20 25 30 Ala Gly Ala Ser
Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 35 40 45 Leu Gln
Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 50 55 60
Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 65
70 75 80 Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys
Lys Ile 85 90 95 Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 100
105 <210> SEQ ID NO 109 <211> LENGTH: 350 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
109 Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn
1 5 10 15 Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys
Met Leu 20 25 30 Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile
Ala Tyr Ala Leu 35 40 45 Val Phe Leu Leu Ser Leu Leu Gly Asn Ser
Leu Val Met Leu Val Ile 50 55 60 Leu Tyr Ser Arg Val Gly Arg Ser
Val Thr Asp Val Tyr Leu Leu Asn 65 70 75 80 Leu Ala Leu Ala Asp Leu
Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 85 90 95 Ala Ser Lys Val
Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 100 105 110 Val Ser
Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 115 120 125
Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 130
135 140 Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly
Cys 145 150 155 160 Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe
Leu Phe Arg Gln 165 170 175 Ala Tyr His Pro Asn Asn Ser Ser Pro Val
Cys Tyr Glu Val Leu Gly 180 185 190 Asn Asp Thr Ala Lys Trp Arg Met
Val Leu Arg Ile Leu Pro His Thr 195 200 205 Phe Gly Phe Ile Val Pro
Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 210 215 220 Thr Leu Arg Thr
Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 225 230 235 240 Met
Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 245 250
255 Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val
260 265 270 Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala
Leu Asp 275 280 285 Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu
Asn Pro Ile Ile 290 295 300 Tyr Ala Phe Ile Gly Gln Asn Phe Arg His
Gly Phe Leu Lys Ile Leu 305 310 315 320 Ala Met His Gly Leu Val Ser
Lys Glu Phe Leu Ala Arg His Arg Val 325 330 335 Thr Ser Tyr Thr Ser
Ser Ser Val Asn Val Ser Ser Asn Leu 340 345 350 <210> SEQ ID
NO 110 <211> LENGTH: 360 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 110 Met Glu Asp Phe
Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 1 5 10 15 Gly Glu
Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 20 25 30
Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 35
40 45 Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu
Leu 50 55 60 Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg
Val Gly Arg 65 70 75 80 Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala
Leu Ala Asp Leu Leu 85 90 95 Phe Ala Leu Thr Leu Pro Ile Trp Ala
Ala Ser Lys Val Asn Gly Trp 100 105 110 Ile Phe Gly Thr Phe Leu Cys
Lys Val Val Ser Leu Leu Lys Glu Val 115 120 125 Asn Phe Tyr Ser Gly
Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 130 135 140 Tyr Leu Ala
Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 145 150 155 160
Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 165
170 175 Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn
Val 180 185 190 Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala
Asn Trp Arg 195 200 205 Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly
Phe Ile Val Pro Leu 210 215 220 Leu Ile Met Leu Phe Cys Tyr Gly Phe
Thr Leu Arg Thr Leu Phe Lys 225 230 235 240 Ala His Met Gly Gln Lys
His Arg Ala Met Arg Val Ile Phe Ala Val 245 250 255 Val Leu Ile Phe
Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 260 265 270 Ala Asp
Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 275 280 285
Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 290
295 300 Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln
Lys 305 310 315 320 Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His
Gly Leu Ile Ser 325 330 335 Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro
Ser Phe Val Gly Ser Ser 340 345 350 Ser Gly His Thr Ser Thr Thr Leu
355 360
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 110
<210> SEQ ID NO 1 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct <400>
SEQUENCE: 1 accacagtcc atgccatcac 20 <210> SEQ ID NO 2
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct <400> SEQUENCE: 2 tccaccaccc
tgttgctgta 20 <210> SEQ ID NO 3 <211> LENGTH: 22
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 3 tcctgatttc tgcagctctg tg 22
<210> SEQ ID NO 4 <211> LENGTH: 22 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct <400>
SEQUENCE: 4 tgcttgaagt ttcactggca tc 22 <210> SEQ ID NO 5
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct <400> SEQUENCE: 5 gagccccgaa
tctgacatta 20 <210> SEQ ID NO 6 <211> LENGTH: 20
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
construct <400> SEQUENCE: 6 gcagacactg caacacacct 20
<210> SEQ ID NO 7 <211> LENGTH: 20 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic construct <400>
SEQUENCE: 7 attctgggca tccttcacag 20 <210> SEQ ID NO 8
<211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic construct <400> SEQUENCE: 8 tgcacttagg
caggaggtct 20 <210> SEQ ID NO 9 <211> LENGTH: 403
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 9 Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg
Asn Lys Arg Arg Tyr 1 5 10 15 Gln Glu Asp Gly Phe Asp Leu Asp Leu
Thr Tyr Ile Tyr Pro Asn Ile 20 25 30 Ile Ala Met Gly Phe Pro Ala
Glu Arg Leu Glu Gly Val Tyr Arg Asn 35 40 45 Asn Ile Asp Asp Val
Val Arg Phe Leu Asp Ser Lys His Lys Asn His 50 55 60 Tyr Lys Ile
Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 65 70 75 80 Phe
Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 85 90
95 Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu
100 105 110 Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala
Gly Lys 115 120 125 Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu
His Arg Gly Lys 130 135 140 Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe
Tyr Gly Glu Val Arg Thr 145 150 155 160 Arg Asp Lys Lys Gly Val Thr
Ile Pro Ser Gln Arg Arg Tyr Val Tyr 165 170 175 Tyr Tyr Ser Tyr Leu
Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 180 185 190 Leu Leu Phe
His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 195 200 205 Gly
Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 210 215
220 Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr
225 230 235 240 Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile
Lys Val Glu 245 250 255 Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys
Asp Lys Met Phe His 260 265 270 Phe Trp Val Asn Thr Phe Phe Ile Pro
Gly Pro Glu Glu Thr Ser Glu 275 280 285 Lys Val Glu Asn Gly Ser Leu
Cys Asp Gln Glu Ile Asp Ser Ile Cys 290 295 300 Ser Ile Glu Arg Ala
Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 305 310 315 320 Thr Lys
Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 325 330 335
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 340
345 350 Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro
Asp 355 360 365 Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp
Thr Thr Asp 370 375 380 Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp
Gln His Thr Gln Ile 385 390 395 400 Thr Lys Val <210> SEQ ID
NO 10 <211> LENGTH: 375 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 10 Met Asp Ala Leu Gln
Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 1 5 10 15 Lys Gln Leu
Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 20 25 30 Ile
Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 35 40
45 Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys
50 55 60 Asp Val Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn
Lys Leu 65 70 75 80 Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu
Tyr Val Asp Lys 85 90 95 Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser
Ser Thr Lys Arg Pro Tyr 100 105 110 Ala Lys Glu Leu Glu Thr Val Asp
Phe Lys Asp Lys Leu Glu Glu Thr 115 120 125 Lys Gly Gln Ile Asn Asn
Ser Ile Lys Asp Leu Thr Asp Gly His Phe 130 135 140 Glu Asn Ile Leu
Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 145 150 155 160 Val
Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Ser 165 170
175 Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Val Asn Lys Thr Asp Thr
180 185 190 Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met
Gly Asn 195 200 205 Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro
Phe Gln Asn Lys 210 215 220 His Leu Ser Met Phe Ile Leu Leu Pro Lys
Asp Val Glu Asp Glu Ser 225 230 235 240 Thr Gly Leu Glu Lys Ile Glu
Lys Gln Leu Asn Ser Glu Ser Leu Ser 245 250 255 Gln Trp Thr Asn Pro
Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 260 265 270 Ile Pro Lys
Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 275 280 285 Glu
Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 290 295
300
Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His 305
310 315 320 Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser Ile
Glu Val 325 330 335 Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu Leu
Asn Ala Asp His 340 345 350 Pro Phe Ile Tyr Ile Ile Arg His Asn Lys
Thr Arg Asn Ile Ile Phe 355 360 365 Phe Gly Lys Phe Cys Ser Pro 370
375 <210> SEQ ID NO 11 <211> LENGTH: 429 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
11 Met Ala Ser Asn Ser Ile Phe Asp Ser Phe Pro Thr Tyr Ser Pro Thr
1 5 10 15 Phe Ile Arg Asp Pro Ser Thr Ser Arg Arg Phe Thr Pro Pro
Ser Pro 20 25 30 Ala Phe Pro Cys Gly Gly Gly Gly Gly Lys Met Gly
Glu Asn Ser Gly 35 40 45 Ala Leu Ser Ala Gln Ala Ala Val Gly Pro
Gly Gly Arg Ala Arg Pro 50 55 60 Glu Val Arg Ser Met Val Asp Val
Leu Ala Asp His Ala Gly Glu Leu 65 70 75 80 Val Arg Thr Asp Ser Pro
Asn Phe Leu Cys Ser Val Leu Pro Ser His 85 90 95 Trp Arg Cys Asn
Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala Leu 100 105 110 Gly Asp
Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn Asp 115 120 125
Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys Asn 130
135 140 Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly
Arg 145 150 155 160 Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr
Asn Pro Thr Gln 165 170 175 Val Ala Thr Tyr His Arg Ala Ile Lys Val
Thr Val Asp Gly Pro Arg 180 185 190 Glu Pro Arg Arg His Arg Gln Lys
Leu Glu Asp Gln Thr Lys Pro Phe 195 200 205 Pro Asp Arg Phe Gly Asp
Leu Glu Arg Leu Arg Met Arg Val Thr Pro 210 215 220 Ser Thr Pro Ser
Pro Arg Gly Ser Leu Ser Thr Thr Ser His Phe Ser 225 230 235 240 Ser
Gln Pro Gln Thr Pro Ile Gln Gly Thr Ser Glu Leu Asn Pro Phe 245 250
255 Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe Pro Thr Leu Pro Thr Leu
260 265 270 Thr Glu Ser Arg Phe Pro Asp Pro Arg Met His Tyr Pro Gly
Ala Met 275 280 285 Ser Ala Ala Phe Pro Tyr Ser Ala Thr Pro Ser Gly
Thr Ser Ile Ser 290 295 300 Ser Leu Ser Val Ala Gly Met Pro Ala Thr
Ser Arg Phe His His Thr 305 310 315 320 Tyr Leu Pro Pro Pro Tyr Pro
Gly Ala Pro Gln Asn Gln Ser Gly Pro 325 330 335 Phe Gln Ala Asn Pro
Ser Pro Tyr His Leu Tyr Tyr Gly Thr Ser Ser 340 345 350 Gly Ser Tyr
Gln Phe Ser Met Val Ala Gly Ser Ser Ser Gly Gly Asp 355 360 365 Arg
Ser Pro Thr Arg Met Leu Ala Ser Cys Thr Ser Ser Ala Ala Ser 370 375
380 Val Ala Ala Gly Asn Leu Met Asn Pro Ser Leu Gly Gly Gln Ser Asp
385 390 395 400 Gly Val Glu Ala Asp Gly Ser His Ser Asn Ser Pro Thr
Ala Leu Ser 405 410 415 Thr Pro Gly Arg Met Asp Glu Ala Val Trp Arg
Pro Tyr 420 425 <210> SEQ ID NO 12 <211> LENGTH: 415
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 12 Met Arg Ile Pro Val Asp Pro Ser Thr Ser
Arg Arg Phe Thr Pro Pro 1 5 10 15 Ser Pro Ala Phe Pro Cys Gly Gly
Gly Gly Gly Lys Met Gly Glu Asn 20 25 30 Ser Gly Ala Leu Ser Ala
Gln Ala Ala Val Gly Pro Gly Gly Arg Ala 35 40 45 Arg Pro Glu Val
Arg Ser Met Val Asp Val Leu Ala Asp His Ala Gly 50 55 60 Glu Leu
Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro 65 70 75 80
Ser His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val 85
90 95 Ala Leu Gly Asp Val Pro Asp Gly Thr Val Val Thr Val Met Ala
Gly 100 105 110 Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser
Ala Val Met 115 120 125 Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg
Phe Val Gly Arg Ser 130 135 140 Gly Arg Gly Lys Ser Phe Thr Leu Thr
Ile Thr Val Phe Thr Asn Pro 145 150 155 160 Thr Gln Val Ala Thr Tyr
His Arg Ala Ile Lys Val Thr Val Asp Gly 165 170 175 Pro Arg Glu Pro
Arg Arg His Arg Gln Lys Leu Glu Asp Gln Thr Lys 180 185 190 Pro Phe
Pro Asp Arg Phe Gly Asp Leu Glu Arg Leu Arg Met Arg Val 195 200 205
Thr Pro Ser Thr Pro Ser Pro Arg Gly Ser Leu Ser Thr Thr Ser His 210
215 220 Phe Ser Ser Gln Pro Gln Thr Pro Ile Gln Gly Thr Ser Glu Leu
Asn 225 230 235 240 Pro Phe Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe
Pro Thr Leu Pro 245 250 255 Thr Leu Thr Glu Ser Arg Phe Pro Asp Pro
Arg Met His Tyr Pro Gly 260 265 270 Ala Met Ser Ala Ala Phe Pro Tyr
Ser Ala Thr Pro Ser Gly Thr Ser 275 280 285 Ile Ser Ser Leu Ser Val
Ala Gly Met Pro Ala Thr Ser Arg Phe His 290 295 300 His Thr Tyr Leu
Pro Pro Pro Tyr Pro Gly Ala Pro Gln Asn Gln Ser 305 310 315 320 Gly
Pro Phe Gln Ala Asn Pro Ser Pro Tyr His Leu Tyr Tyr Gly Thr 325 330
335 Ser Ser Gly Ser Tyr Gln Phe Ser Met Val Ala Gly Ser Ser Ser Gly
340 345 350 Gly Asp Arg Ser Pro Thr Arg Met Leu Ala Ser Cys Thr Ser
Ser Ala 355 360 365 Ala Ser Val Ala Ala Gly Asn Leu Met Asn Pro Ser
Leu Gly Gly Gln 370 375 380 Ser Asp Gly Val Glu Ala Asp Gly Ser His
Ser Asn Ser Pro Thr Ala 385 390 395 400 Leu Ser Thr Pro Gly Arg Met
Asp Glu Ala Val Trp Arg Pro Tyr 405 410 415 <210> SEQ ID NO
13 <211> LENGTH: 178 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 13 Met Ser Gly Gly Lys
Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 1 5 10 15 Pro Ile Arg
Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 20 25 30 Ala
Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 35 40
45 Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val
50 55 60 Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr
His Ser 65 70 75 80 Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe
Thr Val Thr Lys 85 90 95 Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu
Phe Gly Ile Pro Met Ala 100 105 110 Leu Ile Trp Gly Ile Tyr Phe Ala
Ile Leu Ser Phe Leu His Ile Trp 115 120 125 Ala Val Val Pro Cys Ile
Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 130 135 140 Ser Arg Val Tyr
Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 145 150 155 160 Glu
Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 165 170
175 Glu Ile <210> SEQ ID NO 14 <211> LENGTH: 177
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 14 Met Val Leu Leu Ser Thr Leu Gly Ile Val
Phe Gln Gly Glu Gly Pro 1 5 10 15 Pro Ile Ser Ser Cys Asp Thr Gly
Thr Met Ala Asn Cys Glu Arg Thr 20 25 30 Phe Ile Ala Ile Lys Pro
Asp Gly Val Gln Arg Gly Leu Val Gly Glu 35 40 45
Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 50
55 60 Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp
Leu 65 70 75 80 Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met
His Ser Gly 85 90 95 Pro Val Val Ala Met Val Trp Glu Gly Leu Asn
Val Val Lys Thr Gly 100 105 110 Arg Val Met Leu Gly Glu Thr Asn Pro
Ala Asp Ser Lys Pro Gly Thr 115 120 125 Ile Arg Gly Asp Phe Cys Ile
Gln Val Gly Arg Asn Ile Ile His Gly 130 135 140 Ser Asp Ser Val Glu
Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 145 150 155 160 Pro Glu
Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 165 170 175
Glu <210> SEQ ID NO 15 <211> LENGTH: 152 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
15 Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val
1 5 10 15 Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln
Lys Gly 20 25 30 Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser
Glu Asp Leu Leu 35 40 45 Lys Glu His Tyr Val Asp Leu Lys Asp Arg
Pro Phe Phe Ala Gly Leu 50 55 60 Val Lys Tyr Met His Ser Gly Pro
Val Val Ala Met Val Trp Glu Gly 65 70 75 80 Leu Asn Val Val Lys Thr
Gly Arg Val Met Leu Gly Glu Thr Asn Pro 85 90 95 Ala Asp Ser Lys
Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 100 105 110 Gly Arg
Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 115 120 125
Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 130
135 140 Cys Ala Gln Asn Trp Ile Tyr Glu 145 150 <210> SEQ ID
NO 16 <211> LENGTH: 928 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 16 Met Pro Pro Lys Thr
Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 1 5 10 15 Ala Ala Glu
Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 20 25 30 Pro
Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 35 40
45 Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu
50 55 60 Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp
Glu Lys 65 70 75 80 Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile
Gln Lys Lys Lys 85 90 95 Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala
Ala Val Asp Leu Asp Glu 100 105 110 Met Ser Phe Thr Phe Thr Glu Leu
Gln Lys Asn Ile Glu Ile Ser Val 115 120 125 His Lys Phe Phe Asn Leu
Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 130 135 140 Asp Asn Ala Met
Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 145 150 155 160 Leu
Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 165 170
175 Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys
180 185 190 Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu
Gln Met 195 200 205 Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu
Cys Val Leu Asp 210 215 220 Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu
Leu Lys Glu Pro Tyr Lys 225 230 235 240 Thr Ala Val Ile Pro Ile Asn
Gly Ser Pro Arg Thr Pro Arg Arg Gly 245 250 255 Gln Asn Arg Ser Ala
Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 260 265 270 Ile Ile Glu
Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 275 280 285 Lys
Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 290 295
300 Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg
305 310 315 320 Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala
Arg Leu Phe 325 330 335 Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser
Ile Asp Ser Phe Glu 340 345 350 Thr Gln Arg Thr Pro Arg Lys Ser Asn
Leu Asp Glu Glu Val Asn Val 355 360 365 Ile Pro Pro His Thr Pro Val
Arg Thr Val Met Asn Thr Ile Gln Gln 370 375 380 Leu Met Met Ile Leu
Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 385 390 395 400 Ile Ser
Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 405 410 415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 420
425 430 Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys
Leu 435 440 445 Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu
Lys Ser Glu 450 455 460 Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys
Leu Leu Asn Asp Asn 465 470 475 480 Ile Phe His Met Ser Leu Leu Ala
Cys Ala Leu Glu Val Val Met Ala 485 490 495 Thr Tyr Ser Arg Ser Thr
Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 500 505 510 Ser Phe Pro Trp
Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 515 520 525 Tyr Lys
Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 530 535 540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 545
550 555 560 Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys
Gln Ser 565 570 575 Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser
Ala Cys Pro Leu 580 585 590 Asn Leu Pro Leu Gln Asn Asn His Thr Ala
Ala Asp Met Tyr Leu Ser 595 600 605 Pro Val Arg Ser Pro Lys Lys Lys
Gly Ser Thr Thr Arg Val Asn Ser 610 615 620 Thr Ala Asn Ala Glu Thr
Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 625 630 635 640 Pro Leu Lys
Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 645 650 655 Leu
Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 660 665
670 His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu
675 680 685 Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln
Ile Met 690 695 700 Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn
Ile Asp Leu Lys 705 710 715 720 Phe Lys Ile Ile Val Thr Ala Tyr Lys
Asp Leu Pro His Ala Val Gln 725 730 735 Glu Thr Phe Lys Arg Val Leu
Ile Lys Glu Glu Glu Tyr Asp Ser Ile 740 745 750 Ile Val Phe Tyr Asn
Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 755 760 765 Leu Gln Tyr
Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 770 775 780 Ile
Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 785 790
795 800 Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile
Ser 805 810 815 Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser
Arg Ile Leu 820 825 830 Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu
Lys Phe Gln Lys Ile 835 840 845 Asn Gln Met Val Cys Asn Ser Asp Arg
Val Leu Lys Arg Ser Ala Glu 850 855 860 Gly Ser Asn Pro Pro Lys Pro
Leu Lys Lys Leu Arg Phe Asp Ile Glu 865 870 875 880 Gly Ser Asp Glu
Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 885 890 895 Phe Gln
Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 900 905 910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 915
920 925 <210> SEQ ID NO 17 <211> LENGTH: 1043
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 17 Met Pro Leu Leu Glu Gly Ser Val Gly Val
Glu Asp Leu Val Leu Leu 1 5 10 15 Glu Pro Leu Val Glu Glu Ser Leu
Leu Lys Asn Leu Gln Leu Arg Tyr 20 25 30 Glu Asn Lys Glu Ile Tyr
Thr Tyr Ile Gly Asn Val Val Ile Ser Val 35 40 45 Asn Pro Tyr Gln
Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 50 55 60 Tyr Gln
Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 65 70 75 80
Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 85
90 95 Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser
Lys 100 105 110 Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly
Glu Gln Val 115 120 125 Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn
Pro Val Leu Glu Ala 130 135 140 Phe Gly Asn Ala Lys Thr Ile Arg Asn
Asn Asn Ser Ser Arg Phe Gly 145 150 155 160 Lys Tyr Met Asp Ile Glu
Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 165 170 175 Val Ile Thr Asn
Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 180 185 190 Lys Gly
Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 195 200 205
Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 210
215 220 Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp
Asp 225 230 235 240 Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala
Val Ile Gly Phe 245 250 255 Ser Glu Glu Glu Ile Arg Gln Val Leu Glu
Val Thr Ser Met Val Leu 260 265 270 Lys Leu Gly Asn Val Leu Val Ala
Asp Glu Phe Gln Ala Ser Gly Ile 275 280 285 Pro Ala Ser Gly Ile Arg
Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 290 295 300 Met Val Gly Leu
Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 305 310 315 320 Thr
Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 325 330
335 Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg
340 345 350 Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys
Val Gly 355 360 365 Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp
Ile Tyr Gly Phe 370 375 380 Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln
Phe Val Ile Asn Tyr Cys 385 390 395 400 Asn Glu Lys Leu Gln Gln Val
Phe Ile Glu Met Thr Leu Lys Glu Glu 405 410 415 Gln Glu Glu Tyr Lys
Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 420 425 430 Phe Asp Asn
Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 435 440 445 Ile
Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 450 455
460 Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly
465 470 475 480 His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln
Tyr Asp His 485 490 495 Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His
Tyr Ala Gly Lys Val 500 505 510 Thr Tyr Asn Val Thr Ser Phe Ile Asp
Lys Asn Asn Asp Leu Leu Phe 515 520 525 Arg Asp Leu Leu Gln Ala Met
Trp Lys Ala Gln His Pro Leu Leu Arg 530 535 540 Ser Leu Phe Pro Glu
Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 545 550 555 560 Pro Thr
Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 565 570 575
Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 580
585 590 Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr
Gln 595 600 605 Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg
Arg Ala Gly 610 615 620 Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu
Glu Arg Tyr Arg Leu 625 630 635 640 Leu Ser Arg Ser Thr Trp Pro His
Trp Asn Gly Gly Asp Arg Glu Gly 645 650 655 Val Glu Lys Val Leu Gly
Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 660 665 670 Phe Gly Lys Thr
Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 675 680 685 Leu Glu
Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 690 695 700
Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 705
710 715 720 Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn
Met Gln 725 730 735 Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu
Leu Ile Gln Ala 740 745 750 Phe Val Arg Gly Trp Lys Ala Arg Lys Asn
Tyr Arg Lys Tyr Phe Arg 755 760 765 Ser Glu Ala Ala Leu Thr Leu Ala
Asp Phe Ile Tyr Lys Ser Met Val 770 775 780 Gln Lys Phe Leu Leu Gly
Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 785 790 795 800 Leu Asp Lys
Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 805 810 815 Asn
Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 820 825
830 Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu
835 840 845 Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro
Gln Ser 850 855 860 Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu
Gln Gly Asn Pro 865 870 875 880 Lys Leu Gln Lys Leu Lys Gly Gly Glu
Glu Gly Pro Val Leu Met Ala 885 890 895 Glu Ala Val Lys Lys Val Asn
Arg Gly Asn Gly Lys Thr Ser Ser Arg 900 905 910 Ile Leu Leu Leu Thr
Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 915 920 925 Ser Gln Ala
Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 930 935 940 Val
Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 945 950
955 960 Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His
Val 965 970 975 Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp
Ala Thr Gln 980 985 990 Arg Gln Leu Thr Val Thr Val Thr Glu Lys Phe
Ser Val Arg Phe Lys 995 1000 1005 Glu Asn Ser Val Ala Val Lys Val
Val Gln Gly Pro Ala Gly Gly Asp 1010 1015 1020 Asn Ser Lys Leu Arg
Tyr Lys Lys Lys Gly Ser His Cys Leu Glu Val 1025 1030 1035 1040 Thr
Val Gln <210> SEQ ID NO 18 <211> LENGTH: 248
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 18 Met Ala Ala Gly Met Tyr Leu Glu His Tyr
Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe Glu Leu Gln Arg Asn
Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln Arg Thr Glu Asp Leu
Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40 45 Tyr Met Ser Ser
Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 50 55 60 Leu Lys
Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 65 70 75 80
Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 85
90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu
Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser
Ser Lys Gly 115 120 125 Lys Lys Ser Arg Thr Gln Lys Glu Lys Lys Ala
Ala Arg Ala Arg Ser 130 135 140 Lys Gly Lys Asn Ser Asp Glu Glu Ala
Pro Lys Thr Ala Gln Lys Lys 145 150 155 160 Leu Lys Leu Val Arg Thr
Ser Pro Glu Tyr Gly Met Pro Ser Val Thr 165 170 175 Phe Gly Ser Val
His Pro Ser Asp Val Leu Asp Met Pro Val Asp Pro 180 185 190 Asn Glu
Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu Met 195 200 205
Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe Ala 210
215 220 Cys Val Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe Cys Pro
Arg
225 230 235 240 Cys Ser Gln Glu Arg Lys Lys Lys 245 <210> SEQ
ID NO 19 <211> LENGTH: 246 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 19 Met Ala Ala Gly Met
Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe
Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln
Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40
45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu
50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe
Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met
Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg
Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp
Tyr Asp Ser Ser Ser Ser Lys Glu 115 120 125 Gly Arg Thr Gln Lys Glu
Lys Lys Ala Ala Arg Ala Arg Ser Lys Gly 130 135 140 Lys Asn Ser Asp
Glu Glu Ala Pro Lys Thr Ala Gln Lys Lys Leu Lys 145 150 155 160 Leu
Val Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val Thr Phe Gly 165 170
175 Ser Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp Pro Asn Glu
180 185 190 Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu Met
Ile Gly 195 200 205 Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His
Phe Ala Cys Val 210 215 220 Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp
Phe Cys Pro Arg Cys Ser 225 230 235 240 Gln Glu Arg Lys Lys Lys 245
<210> SEQ ID NO 20 <211> LENGTH: 245 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 Met
Ala Ala Gly Met Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10
15 Leu Pro Phe Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp
20 25 30 Gln Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala
Thr Glu 35 40 45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu
Lys Leu Ala Leu 50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys
Cys Lys Glu Phe Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln
Thr Tyr Glu Met Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr
Asp Leu Ala Arg Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile
Glu Ser Ser Asp Tyr Asp Ser Ser Ser Ser Lys Gly 115 120 125 Arg Thr
Gln Lys Glu Lys Lys Ala Ala Arg Ala Arg Ser Lys Gly Lys 130 135 140
Asn Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys Lys Leu Lys Leu 145
150 155 160 Val Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val Thr Phe
Gly Ser 165 170 175 Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp
Pro Asn Glu Pro 180 185 190 Thr Tyr Cys Leu Cys His Gln Val Ser Tyr
Gly Glu Met Ile Gly Cys 195 200 205 Asp Asn Pro Asp Cys Ser Ile Glu
Trp Phe His Phe Ala Cys Val Gly 210 215 220 Leu Thr Thr Lys Pro Arg
Gly Lys Trp Phe Cys Pro Arg Cys Ser Gln 225 230 235 240 Glu Arg Lys
Lys Lys 245 <210> SEQ ID NO 21 <211> LENGTH: 225
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 21 Met Ala Ala Gly Met Tyr Leu Glu His Tyr
Leu Asp Asn Leu Lys Ala 1 5 10 15 Glu Ile Asp Lys Leu Ala Thr Glu
Tyr Met Ser Ser Ala Arg Ser Leu 20 25 30 Ser Ser Glu Glu Lys Leu
Ala Leu Leu Lys Gln Ile Gln Glu Ala Tyr 35 40 45 Gly Lys Cys Lys
Glu Phe Gly Asp Asp Lys Val Gln Leu Ala Met Gln 50 55 60 Thr Tyr
Glu Met Val Asp Lys His Ile Arg Arg Leu Asp Thr Asp Leu 65 70 75 80
Ala Arg Phe Glu Ala Asp Leu Lys Glu Lys Gln Ile Glu Ser Ser Asp 85
90 95 Tyr Asp Ser Ser Ser Ser Lys Gly Lys Lys Lys Gly Arg Thr Gln
Lys 100 105 110 Glu Lys Lys Ala Ala Arg Ala Arg Ser Lys Gly Lys Asn
Ser Asp Glu 115 120 125 Glu Ala Pro Lys Thr Ala Gln Lys Lys Leu Lys
Leu Val Arg Thr Ser 130 135 140 Pro Glu Tyr Gly Met Pro Ser Val Thr
Phe Gly Ser Val His Pro Ser 145 150 155 160 Asp Val Leu Asp Met Pro
Val Asp Pro Asn Glu Pro Thr Tyr Cys Leu 165 170 175 Cys His Gln Val
Ser Tyr Gly Glu Met Ile Gly Cys Asp Asn Pro Asp 180 185 190 Cys Ser
Ile Glu Trp Phe His Phe Ala Cys Val Gly Leu Thr Thr Lys 195 200 205
Pro Arg Gly Lys Trp Phe Cys Pro Arg Cys Ser Gln Glu Arg Lys Lys 210
215 220 Lys 225 <210> SEQ ID NO 22 <211> LENGTH: 179
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 22 Met Ala Ala Gly Met Tyr Leu Glu His Tyr
Leu Asp Ser Ile Glu Asn 1 5 10 15 Leu Pro Phe Glu Leu Gln Arg Asn
Phe Gln Leu Met Arg Asp Leu Asp 20 25 30 Gln Arg Thr Glu Asp Leu
Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 35 40 45 Tyr Met Ser Ser
Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 50 55 60 Leu Lys
Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 65 70 75 80
Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 85
90 95 Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu
Lys 100 105 110 Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser
Ser Lys Gly 115 120 125 Lys Lys Lys Gly Arg Thr Gln Lys Glu Lys Lys
Ala Ala Arg Ala Arg 130 135 140 Ser Lys Gly Lys Asn Ser Asp Glu Glu
Ala Pro Lys Thr Ala Gln Lys 145 150 155 160 Lys Leu Lys Leu Val Arg
Thr Val Pro Leu Ser Gly Ser Ile Leu Pro 165 170 175 Val Trp Gly
<210> SEQ ID NO 23 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 23 Met
Ala Ala Gly Met Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 1 5 10
15 Leu Pro Phe Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp
20 25 30 Gln Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala
Thr Glu 35 40 45 Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu
Lys Leu Ala Leu 50 55 60 Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys
Cys Lys Glu Phe Gly Asp 65 70 75 80 Asp Lys Val Gln Leu Ala Met Gln
Thr Tyr Glu Met Val Asp Lys His 85 90 95 Ile Arg Arg Leu Asp Thr
Asp Leu Ala Arg Phe Glu Ala Asp Leu Lys 100 105 110 Glu Lys Gln Ile
Glu Ser Ser Asp Tyr Asp Ser Ser Ser Ser Lys Gly 115 120 125 Lys Lys
Lys Gly Arg Thr Gln Lys Glu Lys Lys Ala Ala Arg Ala Arg 130 135 140
Ser Lys Gly Lys Asn Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys 145
150 155 160 Lys Leu Lys Leu Val Arg Thr Ser Pro Glu Tyr Gly Met Pro
Ser Val 165 170 175
Thr Phe Gly Ser Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp 180
185 190 Pro Asn Glu Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly
Glu 195 200 205 Met Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp
Phe His Phe 210 215 220 Ala Cys Val Gly Leu Thr Thr Lys Pro Arg Gly
Lys Trp Phe Cys Pro 225 230 235 240 Arg Cys Ser Gln Glu Arg Lys Lys
Lys 245 <210> SEQ ID NO 24 <211> LENGTH: 142
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 24 Met Gly Ala Pro Thr Leu Pro Pro Ala Trp
Gln Pro Phe Leu Lys Asp 1 5 10 15 His Arg Ile Ser Thr Phe Lys Asn
Trp Pro Phe Leu Glu Gly Cys Ala 20 25 30 Cys Thr Pro Glu Arg Met
Ala Glu Ala Gly Phe Ile His Cys Pro Thr 35 40 45 Glu Asn Glu Pro
Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 50 55 60 Glu Gly
Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 65 70 75 80
Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 85
90 95 Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn
Lys 100 105 110 Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu
Glu Thr Ala 115 120 125 Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala
Ala Met Asp 130 135 140 <210> SEQ ID NO 25 <211>
LENGTH: 137 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 25 Met Gly Ala Pro Thr Leu Pro Pro
Ala Trp Gln Pro Phe Leu Lys Asp 1 5 10 15 His Arg Ile Ser Thr Phe
Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 20 25 30 Cys Thr Pro Glu
Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 35 40 45 Glu Asn
Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 50 55 60
Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Thr Ile 65
70 75 80 Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val
Pro Ser 85 90 95 Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg
Ser Cys Leu Val 100 105 110 Pro Glu Trp Leu His His Phe Gln Gly Leu
Phe Pro Gly Ala Thr Ser 115 120 125 Leu Pro Val Gly Pro Leu Ala Met
Ser 130 135 <210> SEQ ID NO 26 <211> LENGTH: 165
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 26 Met Gly Ala Pro Thr Leu Pro Pro Ala Trp
Gln Pro Phe Leu Lys Asp 1 5 10 15 His Arg Ile Ser Thr Phe Lys Asn
Trp Pro Phe Leu Glu Gly Cys Ala 20 25 30 Cys Thr Pro Glu Arg Met
Ala Glu Ala Gly Phe Ile His Cys Pro Thr 35 40 45 Glu Asn Glu Pro
Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 50 55 60 Glu Gly
Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala 65 70 75 80
Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr 85
90 95 Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser
Val 100 105 110 Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly Glu Phe Leu
Lys Leu Asp 115 120 125 Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu
Thr Asn Asn Lys Lys 130 135 140 Lys Glu Phe Glu Glu Thr Ala Glu Lys
Val Arg Arg Ala Ile Glu Gln 145 150 155 160 Leu Ala Ala Met Asp 165
<210> SEQ ID NO 27 <211> LENGTH: 497 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27 Met
Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 1 5 10
15 Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr
20 25 30 Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr
Leu Ala 35 40 45 Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr
Val Arg Cys Phe 50 55 60 Ser Cys His Ala Ala Val Asp Arg Trp Gln
Tyr Gly Asp Ser Ala Val 65 70 75 80 Gly Arg His Arg Lys Val Ser Pro
Asn Cys Arg Phe Ile Asn Gly Phe 85 90 95 Tyr Leu Glu Asn Ser Ala
Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 100 105 110 Gly Gln Tyr Lys
Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 115 120 125 Leu Asp
Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 130 135 140
Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 145
150 155 160 Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro
Asp Tyr 165 170 175 Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly
Leu Tyr Tyr Thr 180 185 190 Gly Ile Gly Asp Gln Val Gln Cys Phe Cys
Cys Gly Gly Lys Leu Lys 195 200 205 Asn Trp Glu Pro Cys Asp Arg Ala
Trp Ser Glu His Arg Arg His Phe 210 215 220 Pro Asn Cys Phe Phe Val
Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 225 230 235 240 Ser Asp Ala
Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 245 250 255 Pro
Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 260 265
270 Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly
275 280 285 Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His
Cys Gly 290 295 300 Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro
Trp Glu Gln His 305 310 315 320 Ala Lys Trp Tyr Pro Gly Cys Lys Tyr
Leu Leu Glu Gln Lys Gly Gln 325 330 335 Glu Tyr Ile Asn Asn Ile His
Leu Thr His Ser Leu Glu Glu Cys Leu 340 345 350 Val Arg Thr Thr Glu
Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 355 360 365 Thr Ile Phe
Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 370 375 380 Ser
Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 385 390
395 400 Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val
Asn 405 410 415 Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr
Ser Leu Gln 420 425 430 Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg
Leu Gln Glu Glu Lys 435 440 445 Leu Cys Lys Ile Cys Met Asp Arg Asn
Ile Ala Ile Val Phe Val Pro 450 455 460 Cys Gly His Leu Val Thr Cys
Lys Gln Cys Ala Glu Ala Val Asp Lys 465 470 475 480 Cys Pro Met Cys
Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490 495 Ser
<210> SEQ ID NO 28 <211> LENGTH: 1403 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 28 Met
Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 1 5 10
15 His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val
20 25 30 Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg
Ala Lys 35 40 45 Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu
Ala Lys Arg Leu 50 55 60 Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser
Ser Trp Ile Pro Gln Glu 65 70 75 80
Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 85
90 95 Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg
Leu 100 105 110 Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly
Phe Leu Leu 115 120 125 Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp
Ile Arg Val Lys Asn 130 135 140 Leu Lys Ser Arg Leu Arg Gly Gly Lys
Met Arg Tyr Gln Glu Glu Glu 145 150 155 160 Ala Arg Leu Ala Ser Phe
Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 165 170 175 Ser Pro Cys Val
Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 180 185 190 Asp Thr
Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 195 200 205
Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 210
215 220 Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr
Ile 225 230 235 240 Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu
His Phe Val Asn 245 250 255 Ser Trp Val Gln Arg Glu Leu Pro Met Ala
Ser Ala Tyr Cys Asn Asp 260 265 270 Ser Ile Phe Ala Tyr Glu Glu Leu
Arg Leu Asp Ser Phe Lys Asp Trp 275 280 285 Pro Arg Glu Ser Ala Val
Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 290 295 300 Phe Tyr Thr Gly
Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 305 310 315 320 Cys
Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 325 330
335 Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala
340 345 350 Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu
Leu Leu 355 360 365 Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile
Ala Val Gly Pro 370 375 380 Ile Val Pro Glu Met Ala Gln Gly Glu Ala
Gln Trp Phe Gln Glu Ala 385 390 395 400 Lys Asn Leu Asn Glu Gln Leu
Arg Ala Ala Tyr Thr Ser Ala Ser Phe 405 410 415 Arg His Met Ser Leu
Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 420 425 430 Leu Leu Gly
Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 435 440 445 Val
Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 450 455
460 Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu
465 470 475 480 Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro
Leu Leu Asn 485 490 495 Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser
Ser Thr Arg Pro Asp 500 505 510 Glu Gly Leu Ala Ser Ile Ile Cys Asp
Gln Leu Leu Glu Lys Glu Gly 515 520 525 Ser Val Thr Glu Met Cys Val
Arg Asn Ile Ile Gln Gln Leu Lys Asn 530 535 540 Gln Val Leu Phe Leu
Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 545 550 555 560 Gln Val
Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 565 570 575
Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 580
585 590 Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr
Val 595 600 605 Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg
Leu Arg Lys 610 615 620 Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu
Gln Lys Ile Gln Lys 625 630 635 640 Thr Pro Leu Phe Val Ala Ala Ile
Cys Ala His Trp Phe Gln Tyr Pro 645 650 655 Phe Asp Pro Ser Phe Asp
Asp Val Ala Val Phe Lys Ser Tyr Met Glu 660 665 670 Arg Leu Ser Leu
Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 675 680 685 Val Ser
Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 690 695 700
Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 705
710 715 720 Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln
Arg Leu 725 730 735 Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln
Glu Phe Leu Ala 740 745 750 Gly Met Arg Leu Ile Glu Leu Leu Asp Ser
Asp Arg Gln Glu His Gln 755 760 765 Asp Leu Gly Leu Tyr His Leu Lys
Gln Ile Asn Ser Pro Met Met Thr 770 775 780 Val Ser Ala Tyr Asn Asn
Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 785 790 795 800 Thr Lys Ala
Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 805 810 815 Asn
Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 820 825
830 His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp
835 840 845 Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His
Leu Leu 850 855 860 Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr
Val Ala Ala Cys 865 870 875 880 Ser Pro Phe Val Leu Gln Phe Leu Gln
Gly Arg Thr Leu Thr Leu Gly 885 890 895 Ala Leu Asn Leu Gln Tyr Phe
Phe Asp His Pro Glu Ser Leu Ser Leu 900 905 910 Leu Arg Ser Ile His
Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 915 920 925 Ala His Phe
Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 930 935 940 Thr
Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 945 950
955 960 Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met
Asp 965 970 975 Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr
Trp Lys Leu 980 985 990 Ser Pro Lys Gln Tyr Lys Ile Pro Cys Leu Glu
Val Asp Val Asn Asp 995 1000 1005 Ile Asp Val Val Gly Gln Asp Met
Leu Glu Ile Leu Met Thr Val Phe 1010 1015 1020 Ser Ala Ser Gln Arg
Ile Glu Leu His Leu Asn His Ser Arg Gly Phe 1025 1030 1035 1040 Ile
Glu Ser Ile Arg Pro Ala Leu Glu Leu Ser Lys Ala Ser Val Thr 1045
1050 1055 Lys Cys Ser Ile Ser Lys Leu Glu Leu Ser Ala Ala Glu Gln
Glu Leu 1060 1065 1070 Leu Leu Thr Leu Pro Ser Leu Glu Ser Leu Glu
Val Ser Gly Thr Ile 1075 1080 1085 Gln Ser Gln Asp Gln Ile Phe Pro
Asn Leu Asp Lys Phe Leu Cys Leu 1090 1095 1100 Lys Glu Leu Ser Val
Asp Leu Glu Gly Asn Ile Asn Val Phe Ser Val 1105 1110 1115 1120 Ile
Pro Glu Glu Phe Pro Asn Phe His His Met Glu Lys Leu Leu Ile 1125
1130 1135 Gln Ile Ser Ala Glu Tyr Asp Pro Ser Lys Leu Val Lys Leu
Ile Gln 1140 1145 1150 Asn Ser Pro Asn Leu His Val Phe His Leu Lys
Cys Asn Phe Phe Ser 1155 1160 1165 Asp Phe Gly Ser Leu Met Thr Met
Leu Val Ser Cys Lys Lys Leu Thr 1170 1175 1180 Glu Ile Lys Phe Ser
Asp Ser Phe Phe Gln Ala Val Pro Phe Val Ala 1185 1190 1195 1200 Ser
Leu Pro Asn Phe Ile Ser Leu Lys Ile Leu Asn Leu Glu Gly Gln 1205
1210 1215 Gln Phe Pro Asp Glu Glu Thr Ser Glu Lys Phe Ala Tyr Ile
Leu Gly 1220 1225 1230 Ser Leu Ser Asn Leu Glu Glu Leu Ile Leu Pro
Thr Gly Asp Gly Ile 1235 1240 1245 Tyr Arg Val Ala Lys Leu Ile Ile
Gln Gln Cys Gln Gln Leu His Cys 1250 1255 1260 Leu Arg Val Leu Ser
Phe Phe Lys Thr Leu Asn Asp Asp Ser Val Val 1265 1270 1275 1280 Glu
Ile Ala Lys Val Ala Ile Ser Gly Gly Phe Gln Lys Leu Glu Asn 1285
1290 1295 Leu Lys Leu Ser Ile Asn His Lys Ile Thr Glu Glu Gly Tyr
Arg Asn 1300 1305 1310 Phe Phe Gln Ala Leu Asp Asn Met Pro Asn Leu
Gln Glu Leu Asp Ile 1315 1320 1325 Ser Arg His Phe Thr Glu Cys Ile
Lys Ala Gln Ala Thr Thr Val Lys 1330 1335 1340 Ser Leu Ser Gln Cys
Val Leu Arg Leu Pro Arg Leu Ile Arg Leu Asn 1345 1350 1355 1360 Met
Leu Ser Trp Leu Leu Asp Ala Asp Asp Ile Ala Leu Leu Asn Val 1365
1370 1375 Met Lys Glu Arg His Pro Gln Ser Lys Tyr Leu Thr Ile Leu
Gln Lys 1380 1385 1390 Trp Ile Leu Pro Phe Ser Pro Ile Ile Gln Lys
1395 1400 <210> SEQ ID NO 29
<211> LENGTH: 1241 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 29 Met Pro Leu His Ile
Gly Asp Phe Val Trp Asp Ser Lys Val His Ser 1 5 10 15 Leu Gln Ser
Ser Leu Asn Ile Phe Ser Leu Leu Pro Thr Lys Gly Arg 20 25 30 Thr
Glu His Leu Phe Phe Ser His Ile Leu Ser Phe His Trp Pro Ala 35 40
45 Phe Ser Ser Ile Arg Leu Glu Leu Trp Ile Asn Leu Arg Cys Glu Phe
50 55 60 Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile
Gln Ser 65 70 75 80 Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe
Val Asn Ser Trp 85 90 95 Val Gln Arg Glu Leu Pro Met Ala Ser Ala
Tyr Cys Asn Asp Ser Ile 100 105 110 Phe Ala Tyr Glu Glu Leu Arg Leu
Asp Ser Phe Lys Asp Trp Pro Arg 115 120 125 Glu Ser Ala Val Gly Val
Ala Ala Leu Ala Lys Ala Gly Leu Phe Tyr 130 135 140 Thr Gly Ile Lys
Asp Ile Val Gln Cys Phe Ser Cys Gly Gly Cys Leu 145 150 155 160 Glu
Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr Arg Cys 165 170
175 Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala Glu Val
180 185 190 Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu
Glu Thr 195 200 205 Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val
Gly Pro Ile Val 210 215 220 Pro Glu Met Ala Gln Gly Glu Ala Gln Trp
Phe Gln Glu Ala Lys Asn 225 230 235 240 Leu Asn Glu Gln Leu Arg Ala
Ala Tyr Thr Ser Ala Ser Phe Arg His 245 250 255 Met Ser Leu Leu Asp
Ile Ser Ser Asp Leu Ala Thr Asp His Leu Leu 260 265 270 Gly Cys Asp
Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro Val Gln 275 280 285 Glu
Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser Val Met 290 295
300 Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu Lys Lys
305 310 315 320 Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu
Asn Arg Phe 325 330 335 Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr
Arg Pro Asp Glu Gly 340 345 350 Leu Ala Ser Ile Ile Cys Asp Gln Leu
Leu Glu Lys Glu Gly Ser Val 355 360 365 Thr Glu Met Cys Val Arg Asn
Ile Ile Gln Gln Leu Lys Asn Gln Val 370 375 380 Leu Phe Leu Leu Asp
Asp Tyr Lys Glu Ile Cys Ser Ile Pro Gln Val 385 390 395 400 Ile Gly
Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys Leu Leu 405 410 415
Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr Leu Glu 420
425 430 Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val Cys
Ile 435 440 445 Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg
Lys Phe Met 450 455 460 Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys
Ile Gln Lys Thr Pro 465 470 475 480 Leu Phe Val Ala Ala Ile Cys Ala
His Trp Phe Gln Tyr Pro Phe Asp 485 490 495 Pro Ser Phe Asp Asp Val
Ala Val Phe Lys Ser Tyr Met Glu Arg Leu 500 505 510 Ser Leu Arg Asn
Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr Val Ser 515 520 525 Ser Cys
Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys Phe Glu 530 535 540
Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp Glu Asp 545
550 555 560 Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu
Arg Pro 565 570 575 Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe
Leu Ala Gly Met 580 585 590 Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg
Gln Glu His Gln Asp Leu 595 600 605 Gly Leu Tyr His Leu Lys Gln Ile
Asn Ser Pro Met Met Thr Val Ser 610 615 620 Ala Tyr Asn Asn Phe Leu
Asn Tyr Val Ser Ser Leu Pro Ser Thr Lys 625 630 635 640 Ala Gly Pro
Lys Ile Val Ser His Leu Leu His Leu Val Asp Asn Lys 645 650 655 Glu
Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys His Gln 660 665
670 Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp Gln Ile
675 680 685 Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu
Val Leu 690 695 700 Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala
Ala Cys Ser Pro 705 710 715 720 Phe Val Leu Gln Phe Leu Gln Gly Arg
Thr Leu Thr Leu Gly Ala Leu 725 730 735 Asn Leu Gln Tyr Phe Phe Asp
His Pro Glu Ser Leu Ser Leu Leu Arg 740 745 750 Ser Ile His Phe Pro
Ile Arg Gly Asn Lys Thr Ser Pro Arg Ala His 755 760 765 Phe Ser Val
Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro Thr Ile 770 775 780 Asp
Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp Glu Arg 785 790
795 800 Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp Met
Gln 805 810 815 Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys
Leu Ser Pro 820 825 830 Lys Gln Tyr Lys Ile Pro Cys Leu Glu Val Asp
Val Asn Asp Ile Asp 835 840 845 Val Val Gly Gln Asp Met Leu Glu Ile
Leu Met Thr Val Phe Ser Ala 850 855 860 Ser Gln Arg Ile Glu Leu His
Leu Asn His Ser Arg Gly Phe Ile Glu 865 870 875 880 Ser Ile Arg Pro
Ala Leu Glu Leu Ser Lys Ala Ser Val Thr Lys Cys 885 890 895 Ser Ile
Ser Lys Leu Glu Leu Ser Ala Ala Glu Gln Glu Leu Leu Leu 900 905 910
Thr Leu Pro Ser Leu Glu Ser Leu Glu Val Ser Gly Thr Ile Gln Ser 915
920 925 Gln Asp Gln Ile Phe Pro Asn Leu Asp Lys Phe Leu Cys Leu Lys
Glu 930 935 940 Leu Ser Val Asp Leu Glu Gly Asn Ile Asn Val Phe Ser
Val Ile Pro 945 950 955 960 Glu Glu Phe Pro Asn Phe His His Met Glu
Lys Leu Leu Ile Gln Ile 965 970 975 Ser Ala Glu Tyr Asp Pro Ser Lys
Leu Val Lys Leu Ile Gln Asn Ser 980 985 990 Pro Asn Leu His Val Phe
His Leu Lys Cys Asn Phe Phe Ser Asp Phe 995 1000 1005 Gly Ser Leu
Met Thr Met Leu Val Ser Cys Lys Lys Leu Thr Glu Ile 1010 1015 1020
Lys Phe Ser Asp Ser Phe Phe Gln Ala Val Pro Phe Val Ala Ser Leu
1025 1030 1035 1040 Pro Asn Phe Ile Ser Leu Lys Ile Leu Asn Leu Glu
Gly Gln Gln Phe 1045 1050 1055 Pro Asp Glu Glu Thr Ser Glu Lys Phe
Ala Tyr Ile Leu Gly Ser Leu 1060 1065 1070 Ser Asn Leu Glu Glu Leu
Ile Leu Pro Thr Gly Asp Gly Ile Tyr Arg 1075 1080 1085 Val Ala Lys
Leu Ile Ile Gln Gln Cys Gln Gln Leu His Cys Leu Arg 1090 1095 1100
Val Leu Ser Phe Phe Lys Thr Leu Asn Asp Asp Ser Val Val Glu Ile
1105 1110 1115 1120 Ala Lys Val Ala Ile Ser Gly Gly Phe Gln Lys Leu
Glu Asn Leu Lys 1125 1130 1135 Leu Ser Ile Asn His Lys Ile Thr Glu
Glu Gly Tyr Arg Asn Phe Phe 1140 1145 1150 Gln Ala Leu Asp Asn Met
Pro Asn Leu Gln Glu Leu Asp Ile Ser Arg 1155 1160 1165 His Phe Thr
Glu Cys Ile Lys Ala Gln Ala Thr Thr Val Lys Ser Leu 1170 1175 1180
Ser Gln Cys Val Leu Arg Leu Pro Arg Leu Ile Arg Leu Asn Met Leu
1185 1190 1195 1200 Ser Trp Leu Leu Asp Ala Asp Asp Ile Ala Leu Leu
Asn Val Met Lys 1205 1210 1215 Glu Arg His Pro Gln Ser Lys Tyr Leu
Thr Ile Leu Gln Lys Trp Ile 1220 1225 1230 Leu Pro Phe Ser Pro Ile
Ile Gln Lys 1235 1240 <210> SEQ ID NO 30 <211> LENGTH:
233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 30 Met Ser Thr Glu Ser Met Ile Arg Asp Val
Glu Leu Ala Glu Glu Ala 1 5 10 15
Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 20
25 30 Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu
Phe 35 40 45 Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu
Glu Phe Pro 50 55 60 Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln
Ala Val Arg Ser Ser 65 70 75 80 Ser Arg Thr Pro Ser Asp Lys Pro Val
Ala His Val Val Ala Asn Pro 85 90 95 Gln Ala Glu Gly Gln Leu Gln
Trp Leu Asn Arg Arg Ala Asn Ala Leu 100 105 110 Leu Ala Asn Gly Val
Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 115 120 125 Glu Gly Leu
Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 130 135 140 Cys
Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 145 150
155 160 Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser
Pro 165 170 175 Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro
Trp Tyr Glu 180 185 190 Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu
Lys Gly Asp Arg Leu 195 200 205 Ser Ala Glu Ile Asn Arg Pro Asp Tyr
Leu Asp Phe Ala Glu Ser Gly 210 215 220 Gln Val Tyr Phe Gly Ile Ile
Ala Leu 225 230 <210> SEQ ID NO 31 <211> LENGTH: 189
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 31 Met Ala Ser Pro Phe Ala Leu Leu Met Val
Leu Val Val Leu Ser Cys 1 5 10 15 Lys Ser Ser Cys Ser Leu Gly Cys
Asp Leu Pro Glu Thr His Ser Leu 20 25 30 Asp Asn Arg Arg Thr Leu
Met Leu Leu Ala Gln Met Ser Arg Ile Ser 35 40 45 Pro Ser Ser Cys
Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 50 55 60 Glu Phe
Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 65 70 75 80
His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 85
90 95 Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu
Leu 100 105 110 Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln
Glu Glu Arg 115 120 125 Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser
Ile Leu Ala Val Lys 130 135 140 Lys Tyr Phe Arg Arg Ile Thr Leu Tyr
Leu Thr Glu Lys Lys Tyr Ser 145 150 155 160 Pro Cys Ala Trp Glu Val
Val Arg Ala Glu Ile Met Arg Ser Leu Ser 165 170 175 Leu Ser Thr Asn
Leu Gln Glu Arg Leu Arg Arg Lys Glu 180 185 <210> SEQ ID NO
32 <211> LENGTH: 187 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 32 Met Thr Asn Lys Cys
Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 1 5 10 15 Thr Thr Ala
Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 20 25 30 Ser
Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 35 40
45 Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu
50 55 60 Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu
Thr Ile 65 70 75 80 Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg
Gln Asp Ser Ser 85 90 95 Ser Thr Gly Trp Asn Glu Thr Ile Val Glu
Asn Leu Leu Ala Asn Val 100 105 110 Tyr His Gln Ile Asn His Leu Lys
Thr Val Leu Glu Glu Lys Leu Glu 115 120 125 Lys Glu Asp Phe Thr Arg
Gly Lys Leu Met Ser Ser Leu His Leu Lys 130 135 140 Arg Tyr Tyr Gly
Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 145 150 155 160 His
Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 165 170
175 Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 180 185 <210>
SEQ ID NO 33 <211> LENGTH: 166 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 Met Lys
Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 1 5 10 15
Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 20
25 30 Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp
Asn 35 40 45 Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu
Glu Ser Asp 50 55 60 Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe
Tyr Phe Lys Leu Phe 65 70 75 80 Lys Asn Phe Lys Asp Asp Gln Ser Ile
Gln Lys Ser Val Glu Thr Ile 85 90 95 Lys Glu Asp Met Asn Val Lys
Phe Phe Asn Ser Asn Lys Lys Lys Arg 100 105 110 Asp Asp Phe Glu Lys
Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 115 120 125 Gln Arg Lys
Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 130 135 140 Pro
Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 145 150
155 160 Gly Arg Arg Ala Ser Gln 165 <210> SEQ ID NO 34
<211> LENGTH: 554 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 34 Met Thr Ala Pro Gly Ala Ala
Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu Leu Leu
Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30 Glu Glu Val
Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35 40 45 Gln
Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 50 55
60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys
65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu
Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala
Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys
Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala Cys Val Arg
Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu Lys Val Lys
Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160 Asp Lys Asp
Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165 170 175 Glu
Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 180 185
190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His
195 200 205 Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr
Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro
Gly Glu Gln Pro 225 230 235 240 Leu His Thr Val Asp Pro Gly Ser Ala
Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr Cys Gln Ser Phe Glu Pro
Pro Glu Thr Pro Val Val Lys Asp Ser 260 265 270 Thr Ile Gly Gly Ser
Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 275 280 285 Pro Gly Met
Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 290 295 300 Pro
Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 305 310
315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr
Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro
Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr
Gly Thr Ala Leu Pro 355 360 365 Arg Val Gly Pro Val Arg Pro Thr Gly
Gln Asp Trp Asn His Thr Pro 370 375 380
Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 385
390 395 400 Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser
Asn Pro 405 410 415 Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser
His Ser Ser Gly 420 425 430 Ser Val Leu Pro Leu Gly Glu Leu Glu Gly
Arg Arg Ser Thr Arg Asp 435 440 445 Arg Arg Ser Pro Ala Glu Pro Glu
Gly Gly Pro Ala Ser Glu Gly Ala 450 455 460 Ala Arg Pro Leu Pro Arg
Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 465 470 475 480 His Glu Arg
Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 485 490 495 Val
Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 500 505
510 Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro
515 520 525 Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro
Leu Thr 530 535 540 Gln Asp Asp Arg Gln Val Glu Leu Pro Val 545 550
<210> SEQ ID NO 35 <211> LENGTH: 554 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 35 Met
Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10
15 Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr
20 25 30 Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly
His Leu 35 40 45 Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu
Thr Ser Cys Gln 50 55 60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln
Leu Lys Asp Pro Val Cys 65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu
Val Gln Asp Ile Met Glu Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn
Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser
Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His
Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145
150 155 160 Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser
Phe Ala 165 170 175 Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp
Cys Asn Cys Leu 180 185 190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro
Ala Ser Val Ser Pro His 195 200 205 Gln Pro Leu Ala Pro Ser Met Ala
Pro Val Ala Gly Leu Thr Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu
Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 225 230 235 240 Leu His Thr
Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr
Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 260 265
270 Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn
275 280 285 Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn
Trp Val 290 295 300 Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro
Val Pro Gln Gly 305 310 315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly
Gly Gly Ser Met Gln Thr Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe
Leu Ser Ala Ser Ser Pro Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln
Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 355 360 365 Arg Val Gly
Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 370 375 380 Gln
Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 385 390
395 400 Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn
Pro 405 410 415 Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His
Ser Ser Gly 420 425 430 Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg
Arg Ser Thr Arg Asp 435 440 445 Arg Arg Ser Pro Ala Glu Pro Glu Gly
Gly Pro Ala Ser Glu Gly Ala 450 455 460 Ala Arg Pro Leu Pro Arg Phe
Asn Ser Val Pro Leu Thr Asp Thr Gly 465 470 475 480 His Glu Arg Gln
Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 485 490 495 Val Phe
His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 500 505 510
Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 515
520 525 Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu
Thr 530 535 540 Gln Asp Asp Arg Gln Val Glu Leu Pro Val 545 550
<210> SEQ ID NO 36 <211> LENGTH: 438 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 Met
Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10
15 Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr
20 25 30 Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly
His Leu 35 40 45 Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu
Thr Ser Cys Gln 50 55 60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln
Leu Lys Asp Pro Val Cys 65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu
Val Gln Asp Ile Met Glu Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn
Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser
Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His
Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145
150 155 160 Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser
Phe Ala 165 170 175 Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp
Cys Asn Cys Leu 180 185 190 Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro
Ala Ser Val Ser Pro His 195 200 205 Gln Pro Leu Ala Pro Ser Met Ala
Pro Val Ala Gly Leu Thr Trp Glu 210 215 220 Asp Ser Glu Gly Thr Glu
Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 225 230 235 240 Leu His Thr
Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 245 250 255 Thr
Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 260 265
270 Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn
275 280 285 Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn
Trp Val 290 295 300 Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro
Val Pro Gln Gly 305 310 315 320 Thr Glu Leu Ser Pro Ser Arg Pro Gly
Gly Gly Ser Met Gln Thr Glu 325 330 335 Pro Ala Arg Pro Ser Asn Phe
Leu Ser Ala Ser Ser Pro Leu Pro Ala 340 345 350 Ser Ala Lys Gly Gln
Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 355 360 365 Ser Glu Gly
Ser Ser Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 370 375 380 Leu
Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 385 390
395 400 Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala
Asp 405 410 415 Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln
Asp Asp Arg 420 425 430 Gln Val Glu Leu Pro Val 435 <210> SEQ
ID NO 37 <211> LENGTH: 256 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 37 Met Thr Ala Pro Gly
Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 1 5 10 15 Gly Ser Leu
Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 20 25 30
Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 35
40 45 Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys
Gln 50 55 60 Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp
Pro Val Cys 65 70 75 80 Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp
Ile Met Glu Asp Thr 85 90 95 Met Arg Phe Arg Asp Asn Thr Pro Asn
Ala Ile Ala Ile Val Gln Leu 100 105 110 Gln Glu Leu Ser Leu Arg Leu
Lys Ser Cys Phe Thr Lys Asp Tyr Glu 115 120 125 Glu His Asp Lys Ala
Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 130 135 140 Leu Leu Glu
Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 145 150 155 160
Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 165
170 175 Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser
Ser 180 185 190 Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro
Ser Val Ile 195 200 205 Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe
Tyr Arg Trp Arg Arg 210 215 220 Arg Ser His Gln Glu Pro Gln Arg Ala
Asp Ser Pro Leu Glu Gln Pro 225 230 235 240 Glu Gly Ser Pro Leu Thr
Gln Asp Asp Arg Gln Val Glu Leu Pro Val 245 250 255 <210> SEQ
ID NO 38 <211> LENGTH: 144 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 38 Met Trp Leu Gln Ser
Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 1 5 10 15 Ser Ala Pro
Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 20 25 30 Val
Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 35 40
45 Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe
50 55 60 Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu
Tyr Lys 65 70 75 80 Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly
Pro Leu Thr Met 85 90 95 Met Ala Ser His Tyr Lys Gln His Cys Pro
Pro Thr Pro Glu Thr Ser 100 105 110 Cys Ala Thr Gln Ile Ile Thr Phe
Glu Ser Phe Lys Glu Asn Leu Lys 115 120 125 Asp Phe Leu Leu Val Ile
Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 130 135 140 <210> SEQ
ID NO 39 <211> LENGTH: 207 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 39 Met Ala Gly Pro Ala
Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 1 5 10 15 Leu Leu Leu
Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 20 25 30 Leu
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 35 40
45 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys
50 55 60 Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu
Glu Leu 65 70 75 80 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala
Pro Leu Ser Ser 85 90 95 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly
Cys Leu Ser Gln Leu His 100 105 110 Ser Gly Leu Phe Leu Tyr Gln Gly
Leu Leu Gln Ala Leu Glu Gly Ile 115 120 125 Ser Pro Glu Leu Gly Pro
Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 130 135 140 Asp Phe Ala Thr
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 145 150 155 160 Pro
Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 165 170
175 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser
180 185 190 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln
Pro 195 200 205 <210> SEQ ID NO 40 <211> LENGTH: 204
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 40 Met Ala Gly Pro Ala Thr Gln Ser Pro Met
Lys Leu Met Ala Leu Gln 1 5 10 15 Leu Leu Leu Trp His Ser Ala Leu
Trp Thr Val Gln Glu Ala Thr Pro 20 25 30 Leu Gly Pro Ala Ser Ser
Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 35 40 45 Glu Gln Val Arg
Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 50 55 60 Leu Cys
Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 65 70 75 80
Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 85
90 95 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly
Leu 100 105 110 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile
Ser Pro Glu 115 120 125 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp
Val Ala Asp Phe Ala 130 135 140 Thr Thr Ile Trp Gln Gln Met Glu Glu
Leu Gly Met Ala Pro Ala Leu 145 150 155 160 Gln Pro Thr Gln Gly Ala
Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 165 170 175 Arg Ala Gly Gly
Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 180 185 190 Val Ser
Tyr Arg Val Leu Arg His Leu Ala Gln Pro 195 200 <210> SEQ ID
NO 41 <211> LENGTH: 200 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 41 Met Ser Pro Glu Pro
Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 1 5 10 15 His Ser Ala
Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly Pro Ala 20 25 30 Ser
Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 35 40
45 Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr
50 55 60 Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His
Ser Leu 65 70 75 80 Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser
Gln Ala Leu Gln 85 90 95 Leu Ala Gly Cys Leu Ser Gln Leu His Ser
Gly Leu Phe Leu Tyr Gln 100 105 110 Gly Leu Leu Gln Ala Leu Glu Gly
Ile Ser Pro Glu Leu Gly Pro Thr 115 120 125 Leu Asp Thr Leu Gln Leu
Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 130 135 140 Gln Gln Met Glu
Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 145 150 155 160 Gly
Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170
175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg
180 185 190 Val Leu Arg His Leu Ala Gln Pro 195 200 <210> SEQ
ID NO 42 <211> LENGTH: 393 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 42 Met Glu Glu Pro Gln
Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe
Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser
Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40
45 Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
50 55 60 Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala
Ala Pro 65 70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro
Leu Ser Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser
Tyr Gly Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys
Ser Val Thr Cys Thr Tyr Ser Pro 115 120 125
Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 130
135 140 Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala
Met 145 150 155 160 Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val
Val Arg Arg Cys 165 170 175 Pro His His Glu Arg Cys Ser Asp Ser Asp
Gly Leu Ala Pro Pro Gln 180 185 190 His Leu Ile Arg Val Glu Gly Asn
Leu Arg Val Glu Tyr Leu Asp Asp 195 200 205 Arg Asn Thr Phe Arg His
Ser Val Val Val Pro Tyr Glu Pro Pro Glu 210 215 220 Val Gly Ser Asp
Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 225 230 235 240 Ser
Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 245 250
255 Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
260 265 270 Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu
Glu Asn 275 280 285 Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro
Pro Gly Ser Thr 290 295 300 Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser
Ser Pro Gln Pro Lys Lys 305 310 315 320 Lys Pro Leu Asp Gly Glu Tyr
Phe Thr Leu Gln Ile Arg Gly Arg Glu 325 330 335 Arg Phe Glu Met Phe
Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 340 345 350 Ala Gln Ala
Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 355 360 365 Leu
Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 370 375
380 Phe Lys Thr Glu Gly Pro Asp Ser Asp 385 390 <210> SEQ ID
NO 43 <211> LENGTH: 393 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 43 Met Glu Glu Pro Gln
Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe
Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser
Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40
45 Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
50 55 60 Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala
Ala Pro 65 70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro
Leu Ser Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser
Tyr Gly Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys
Ser Val Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe
Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp
Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala
Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170
175 Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
180 185 190 His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu
Asp Asp 195 200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr
Glu Pro Pro Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr
Asn Tyr Met Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn
Arg Arg Pro Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser
Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys
Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu
Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295
300 Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305 310 315 320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg
Gly Arg Glu 325 330 335 Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala
Leu Glu Leu Lys Asp 340 345 350 Ala Gln Ala Gly Lys Glu Pro Gly Gly
Ser Arg Ala His Ser Ser His 355 360 365 Leu Lys Ser Lys Lys Gly Gln
Ser Thr Ser Arg His Lys Lys Leu Met 370 375 380 Phe Lys Thr Glu Gly
Pro Asp Ser Asp 385 390 <210> SEQ ID NO 44 <211>
LENGTH: 341 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 44 Met Glu Glu Pro Gln Ser Asp Pro
Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe Ser Asp Leu
Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser Pro Leu Pro
Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40 45 Asp Ile
Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 50 55 60
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 65
70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser
Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly
Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys Ser Val
Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe Cys Gln
Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp Ser Thr
Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala Ile Tyr
Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170 175 Pro
His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 180 185
190 His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
195 200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro
Pro Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr
Met Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn Arg Arg
Pro Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser Gly Asn
Leu Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys Ala Cys
Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu Arg Lys
Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295 300 Lys
Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 305 310
315 320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser
Phe 325 330 335 Gln Lys Glu Asn Cys 340 <210> SEQ ID NO 45
<211> LENGTH: 346 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 45 Met Glu Glu Pro Gln Ser Asp
Pro Ser Val Glu Pro Pro Leu Ser Gln 1 5 10 15 Glu Thr Phe Ser Asp
Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 20 25 30 Ser Pro Leu
Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 35 40 45 Asp
Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 50 55
60 Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro
65 70 75 80 Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser
Ser Ser 85 90 95 Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly
Phe Arg Leu Gly 100 105 110 Phe Leu His Ser Gly Thr Ala Lys Ser Val
Thr Cys Thr Tyr Ser Pro 115 120 125 Ala Leu Asn Lys Met Phe Cys Gln
Leu Ala Lys Thr Cys Pro Val Gln 130 135 140 Leu Trp Val Asp Ser Thr
Pro Pro Pro Gly Thr Arg Val Arg Ala Met 145 150 155 160 Ala Ile Tyr
Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 165 170 175 Pro
His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 180 185
190
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 195
200 205 Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro
Glu 210 215 220 Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met
Cys Asn Ser 225 230 235 240 Ser Cys Met Gly Gly Met Asn Arg Arg Pro
Ile Leu Thr Ile Ile Thr 245 250 255 Leu Glu Asp Ser Ser Gly Asn Leu
Leu Gly Arg Asn Ser Phe Glu Val 260 265 270 Arg Val Cys Ala Cys Pro
Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 275 280 285 Leu Arg Lys Lys
Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 290 295 300 Lys Arg
Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 305 310 315
320 Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu
325 330 335 Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 340 345
<210> SEQ ID NO 46 <211> LENGTH: 261 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 Met
Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 1 5 10
15 Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys
20 25 30 Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His
His Glu 35 40 45 Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
His Leu Ile Arg 50 55 60 Val Glu Gly Asn Leu Arg Val Glu Tyr Leu
Asp Asp Arg Asn Thr Phe 65 70 75 80 Arg His Ser Val Val Val Pro Tyr
Glu Pro Pro Glu Val Gly Ser Asp 85 90 95 Cys Thr Thr Ile His Tyr
Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 100 105 110 Gly Met Asn Arg
Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 115 120 125 Ser Gly
Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 130 135 140
Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 145
150 155 160 Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg
Ala Leu 165 170 175 Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
Lys Pro Leu Asp 180 185 190 Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly
Arg Glu Arg Phe Glu Met 195 200 205 Phe Arg Glu Leu Asn Glu Ala Leu
Glu Leu Lys Asp Ala Gln Ala Gly 210 215 220 Lys Glu Pro Gly Gly Ser
Arg Ala His Ser Ser His Leu Lys Ser Lys 225 230 235 240 Lys Gly Gln
Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 245 250 255 Gly
Pro Asp Ser Asp 260 <210> SEQ ID NO 47 <211> LENGTH:
209 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 47 Met Phe Cys Gln Leu Ala Lys Thr Cys Pro
Val Gln Leu Trp Val Asp 1 5 10 15 Ser Thr Pro Pro Pro Gly Thr Arg
Val Arg Ala Met Ala Ile Tyr Lys 20 25 30 Gln Ser Gln His Met Thr
Glu Val Val Arg Arg Cys Pro His His Glu 35 40 45 Arg Cys Ser Asp
Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 50 55 60 Val Glu
Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 65 70 75 80
Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 85
90 95 Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met
Gly 100 105 110 Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu
Glu Asp Ser 115 120 125 Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu
Val Arg Val Cys Ala 130 135 140 Cys Pro Gly Arg Asp Arg Arg Thr Glu
Glu Glu Asn Leu Arg Lys Lys 145 150 155 160 Gly Glu Pro His His Glu
Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 165 170 175 Pro Asn Asn Thr
Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 180 185 190 Gly Glu
Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 195 200 205
Cys <210> SEQ ID NO 48 <211> LENGTH: 214 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
48 Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp
1 5 10 15 Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile
Tyr Lys 20 25 30 Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
Pro His His Glu 35 40 45 Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro
Pro Gln His Leu Ile Arg 50 55 60 Val Glu Gly Asn Leu Arg Val Glu
Tyr Leu Asp Asp Arg Asn Thr Phe 65 70 75 80 Arg His Ser Val Val Val
Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 85 90 95 Cys Thr Thr Ile
His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 100 105 110 Gly Met
Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 115 120 125
Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 130
135 140 Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys
Lys 145 150 155 160 Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
Lys Arg Ala Leu 165 170 175 Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro
Lys Lys Lys Pro Leu Asp 180 185 190 Gly Glu Tyr Phe Thr Leu Gln Met
Leu Leu Asp Leu Arg Trp Cys Tyr 195 200 205 Phe Leu Ile Asn Ser Ser
210 <210> SEQ ID NO 49 <211> LENGTH: 1237 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
49 Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu
1 5 10 15 Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile
Ser Asp 20 25 30 Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg
Asn Glu Pro Thr 35 40 45 Gln Gln Gln Arg Ala Ala Met Leu Ile Lys
Met Ile Leu Lys Lys Asp 50 55 60 Asn Asp Ser Tyr Val Ser Phe Tyr
Asn Ala Leu Leu His Glu Gly Tyr 65 70 75 80 Lys Asp Leu Ala Ala Leu
Leu His Asp Gly Ile Pro Val Val Ser Ser 85 90 95 Ser Ser Val Arg
Thr Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro 100 105 110 Val Val
Phe Val Thr Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys 115 120 125
Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val Thr Ile His Gly Met 130
135 140 Ala Gly Cys Gly Lys Ser Val Leu Ala Ala Glu Ala Val Arg Asp
His 145 150 155 160 Ser Leu Leu Glu Gly Cys Phe Pro Gly Gly Val His
Trp Val Ser Val 165 170 175 Gly Lys Gln Asp Lys Ser Gly Leu Leu Met
Lys Leu Gln Asn Leu Cys 180 185 190 Thr Arg Leu Asp Gln Asp Glu Ser
Phe Ser Gln Arg Leu Pro Leu Asn 195 200 205 Ile Glu Glu Ala Lys Asp
Arg Leu Arg Ile Leu Met Leu Arg Lys His 210 215 220 Pro Arg Ser Leu
Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu 225 230 235 240 Lys
Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Thr Thr Arg Asp Lys 245 250
255 Ser Val Thr Asp Ser Val Met Gly Pro Lys Tyr Val Val Pro Val Glu
260 265 270 Ser Ser Leu Gly Lys Glu Lys Gly Leu Glu Ile Leu Ser Leu
Phe Val 275 280 285 Asn Met Lys Lys Ala Asp Leu Pro Glu Gln Ala His
Ser Ile Ile Lys
290 295 300 Glu Cys Lys Gly Ser Pro Leu Val Val Ser Leu Ile Gly Ala
Leu Leu 305 310 315 320 Arg Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu
Lys Gln Leu Gln Asn 325 330 335 Lys Gln Phe Lys Arg Ile Arg Lys Ser
Ser Ser Tyr Asp Tyr Glu Ala 340 345 350 Leu Asp Glu Ala Met Ser Ile
Ser Val Glu Met Leu Arg Glu Asp Ile 355 360 365 Lys Asp Tyr Tyr Thr
Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val 370 375 380 Pro Thr Lys
Val Leu Cys Ile Leu Trp Asp Met Glu Thr Glu Glu Val 385 390 395 400
Glu Asp Ile Leu Gln Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp 405
410 415 Arg Asn Gly Lys Ser Phe Arg Tyr Tyr Leu His Asp Leu Gln Val
Asp 420 425 430 Phe Leu Thr Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu
His Lys Lys 435 440 445 Ile Ile Thr Gln Phe Gln Arg Tyr His Gln Pro
His Thr Leu Ser Pro 450 455 460 Asp Gln Glu Asp Cys Met Tyr Trp Tyr
Asn Phe Leu Ala Tyr His Met 465 470 475 480 Ala Ser Ala Lys Met His
Lys Glu Leu Cys Ala Leu Met Phe Ser Leu 485 490 495 Asp Trp Ile Lys
Ala Lys Thr Glu Leu Val Gly Pro Ala His Leu Ile 500 505 510 His Glu
Phe Val Glu Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala 515 520 525
Val Ser Glu Asn Phe Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu 530
535 540 Gly Arg Gln Pro Phe Pro Asn Ile Val Gln Leu Gly Leu Cys Glu
Pro 545 550 555 560 Glu Thr Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln
Ala Lys Gln Glu 565 570 575 Val Asp Asn Gly Met Leu Tyr Leu Glu Trp
Ile Asn Lys Lys Asn Ile 580 585 590 Thr Asn Leu Ser Arg Leu Val Val
Arg Pro His Thr Asp Ala Val Tyr 595 600 605 His Ala Cys Phe Ser Glu
Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala 610 615 620 Asp Lys Thr Leu
Gln Val Phe Lys Ala Glu Thr Gly Glu Lys Leu Leu 625 630 635 640 Glu
Ile Lys Ala His Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Thr 645 650
655 Asp Asp Arg Phe Ile Ala Thr Cys Ser Val Asp Lys Lys Val Lys Ile
660 665 670 Trp Asn Ser Met Thr Gly Glu Leu Val His Thr Tyr Asp Glu
His Ser 675 680 685 Glu Gln Val Asn Cys Cys His Phe Thr Asn Ser Ser
His His Leu Leu 690 695 700 Leu Ala Thr Gly Ser Ser Asp Cys Phe Leu
Lys Leu Trp Asp Leu Asn 705 710 715 720 Gln Lys Glu Cys Arg Asn Thr
Met Phe Gly His Thr Asn Ser Val Asn 725 730 735 His Cys Arg Phe Ser
Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala 740 745 750 Asp Gly Thr
Leu Lys Leu Trp Asp Ala Thr Ser Ala Asn Glu Arg Lys 755 760 765 Ser
Ile Asn Val Lys Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu 770 775
780 Asp Met Glu Val Ile Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala
785 790 795 800 Arg Ile Met Val Ala Ala Lys Asn Lys Ile Phe Leu Phe
Asp Ile His 805 810 815 Thr Ser Gly Leu Leu Gly Glu Ile His Thr Gly
His His Ser Thr Ile 820 825 830 Gln Tyr Cys Asp Phe Ser Pro Gln Asn
His Leu Ala Val Val Ala Leu 835 840 845 Ser Gln Tyr Cys Val Glu Leu
Trp Asn Thr Asp Ser Arg Ser Lys Val 850 855 860 Ala Asp Cys Arg Gly
His Leu Ser Trp Val His Gly Val Met Phe Ser 865 870 875 880 Pro Asp
Gly Ser Ser Phe Leu Thr Ser Ser Asp Asp Gln Thr Ile Arg 885 890 895
Leu Trp Glu Thr Lys Lys Val Cys Lys Asn Ser Ala Val Met Leu Lys 900
905 910 Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu Val Met Val Leu
Ala 915 920 925 Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn Gly Arg
Thr Gly Gln 930 935 940 Ile Asp Tyr Leu Thr Glu Ala Gln Val Ser Cys
Cys Cys Leu Ser Pro 945 950 955 960 His Leu Gln Tyr Ile Ala Phe Gly
Asp Glu Asn Gly Ala Ile Glu Ile 965 970 975 Leu Glu Leu Val Asn Asn
Arg Ile Phe Gln Ser Arg Phe Gln His Lys 980 985 990 Lys Thr Val Trp
His Ile Gln Phe Thr Ala Asp Glu Lys Thr Leu Ile 995 1000 1005 Ser
Ser Ser Asp Asp Ala Glu Ile Gln Val Trp Asn Trp Gln Leu Asp 1010
1015 1020 Lys Cys Ile Phe Leu Arg Gly His Gln Glu Thr Val Lys Asp
Phe Arg 1025 1030 1035 1040 Leu Leu Lys Asn Ser Arg Leu Leu Ser Trp
Ser Phe Asp Gly Thr Val 1045 1050 1055 Lys Val Trp Asn Ile Ile Thr
Gly Asn Lys Glu Lys Asp Phe Val Cys 1060 1065 1070 His Gln Gly Thr
Val Leu Ser Cys Asp Ile Ser His Asp Ala Thr Lys 1075 1080 1085 Phe
Ser Ser Thr Ser Ala Asp Lys Thr Ala Lys Ile Trp Ser Phe Asp 1090
1095 1100 Leu Leu Leu Pro Leu His Glu Leu Arg Gly His Asn Gly Cys
Val Arg 1105 1110 1115 1120 Cys Ser Ala Phe Ser Val Asp Ser Thr Leu
Leu Ala Thr Gly Asp Asp 1125 1130 1135 Asn Gly Glu Ile Arg Ile Trp
Asn Val Ser Asn Gly Glu Leu Leu His 1140 1145 1150 Leu Cys Ala Pro
Leu Ser Glu Glu Gly Ala Ala Thr His Gly Gly Trp 1155 1160 1165 Val
Thr Asp Leu Cys Phe Ser Pro Asp Gly Lys Met Leu Ile Ser Ala 1170
1175 1180 Gly Gly Tyr Ile Lys Trp Trp Asn Val Val Thr Gly Glu Ser
Ser Gln 1185 1190 1195 1200 Thr Phe Tyr Thr Asn Gly Thr Asn Leu Lys
Lys Ile His Val Ser Pro 1205 1210 1215 Asp Phe Lys Thr Tyr Val Thr
Val Asp Asn Leu Gly Ile Leu Tyr Ile 1220 1225 1230 Leu Gln Thr Leu
Glu 1235 <210> SEQ ID NO 50 <211> LENGTH: 1194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 50 Met Asp Ala Lys Ala Arg Asn Cys Leu Leu
Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp Ile Lys Thr Ser Tyr
Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly Phe Leu Thr Ile Ser
Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40 45 Gln Gln Gln Arg
Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 50 55 60 Asn Asp
Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 65 70 75 80
Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 85
90 95 Ser Ser Val Arg Thr Val Leu Cys Glu Gly Gly Val Pro Gln Arg
Pro 100 105 110 Val Val Phe Val Thr Arg Lys Lys Leu Val Asn Ala Ile
Gln Gln Lys 115 120 125 Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val
Thr Ile His Gly Met 130 135 140 Ala Gly Cys Gly Lys Ser Val Leu Ala
Ala Glu Ala Val Arg Asp His 145 150 155 160 Ser Leu Leu Glu Gly Cys
Phe Pro Gly Gly Val His Trp Val Ser Val 165 170 175 Gly Lys Gln Asp
Lys Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys 180 185 190 Thr Arg
Leu Asp Gln Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn 195 200 205
Ile Glu Glu Ala Lys Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His 210
215 220 Pro Arg Ser Leu Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val
Leu 225 230 235 240 Lys Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Thr
Thr Arg Asp Lys 245 250 255 Ser Val Thr Asp Ser Val Met Gly Pro Lys
Tyr Val Val Pro Val Glu 260 265 270 Ser Ser Leu Gly Lys Glu Lys Gly
Leu Glu Ile Leu Ser Leu Phe Val 275 280 285 Asn Met Lys Lys Ala Asp
Leu Pro Glu Gln Ala His Ser Ile Ile Lys 290 295 300 Glu Cys Lys Gly
Ser Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu 305 310 315 320 Arg
Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 325 330
335 Lys Gln Phe Lys Arg Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu
Ala
340 345 350 Leu Asp Glu Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu
Asp Ile 355 360 365 Lys Asp Tyr Tyr Thr Asp Leu Ser Ile Leu Gln Lys
Asp Val Lys Val 370 375 380 Pro Thr Lys Val Leu Cys Ile Leu Trp Asp
Met Glu Thr Glu Glu Val 385 390 395 400 Glu Asp Ile Leu Gln Glu Phe
Val Asn Lys Ser Leu Leu Phe Cys Asp 405 410 415 Arg Asn Gly Lys Ser
Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp 420 425 430 Phe Leu Thr
Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys 435 440 445 Ile
Ile Thr Gln Phe Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro 450 455
460 Asp Gln Glu Asp Cys Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met
465 470 475 480 Ala Ser Ala Lys Met His Lys Glu Leu Cys Ala Leu Met
Phe Ser Leu 485 490 495 Asp Trp Ile Lys Ala Lys Thr Glu Leu Val Gly
Pro Ala His Leu Ile 500 505 510 His Glu Phe Val Glu Tyr Arg His Ile
Leu Asp Glu Lys Asp Cys Ala 515 520 525 Val Ser Glu Asn Phe Gln Glu
Phe Leu Ser Leu Asn Gly His Leu Leu 530 535 540 Gly Arg Gln Pro Phe
Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro 545 550 555 560 Glu Thr
Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu 565 570 575
Val Asp Asn Gly Met Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 580
585 590 Thr Asn Leu Ser Arg Leu Val Val Arg Pro His Thr Asp Ala Val
Tyr 595 600 605 His Ala Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser
Cys Gly Ala 610 615 620 Asp Lys Thr Leu Gln Val Phe Lys Ala Glu Thr
Gly Glu Lys Leu Leu 625 630 635 640 Glu Ile Lys Ala His Glu Asp Glu
Val Leu Cys Cys Ala Phe Ser Thr 645 650 655 Asp Asp Arg Phe Ile Ala
Thr Cys Ser Val Asp Lys Lys Val Lys Ile 660 665 670 Trp Asn Ser Met
Thr Gly Glu Leu Val His Thr Tyr Asp Glu His Ser 675 680 685 Glu Gln
Val Asn Cys Cys His Phe Thr Asn Ser Ser His His Leu Leu 690 695 700
Leu Ala Thr Gly Ser Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 705
710 715 720 Gln Lys Glu Cys Arg Asn Thr Met Phe Gly His Thr Asn Ser
Val Asn 725 730 735 His Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala
Ser Cys Ser Ala 740 745 750 Asp Gly Thr Leu Lys Leu Trp Asp Ala Thr
Ser Ala Asn Glu Arg Lys 755 760 765 Ser Ile Asn Val Lys Gln Phe Phe
Leu Asn Leu Glu Asp Pro Gln Glu 770 775 780 Asp Met Glu Val Ile Val
Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala 785 790 795 800 Arg Ile Met
Val Ala Ala Lys Asn Lys Ile Phe Leu Trp Asn Thr Asp 805 810 815 Ser
Arg Ser Lys Val Ala Asp Cys Arg Gly His Leu Ser Trp Val His 820 825
830 Gly Val Met Phe Ser Pro Asp Gly Ser Ser Phe Leu Thr Ser Ser Asp
835 840 845 Asp Gln Thr Ile Arg Leu Trp Glu Thr Lys Lys Val Cys Lys
Asn Ser 850 855 860 Ala Val Met Leu Lys Gln Glu Val Asp Val Val Phe
Gln Glu Asn Glu 865 870 875 880 Val Met Val Leu Ala Val Asp His Ile
Arg Arg Leu Gln Leu Ile Asn 885 890 895 Gly Arg Thr Gly Gln Ile Asp
Tyr Leu Thr Glu Ala Gln Val Ser Cys 900 905 910 Cys Cys Leu Ser Pro
His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn 915 920 925 Gly Ala Ile
Glu Ile Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser 930 935 940 Arg
Phe Gln His Lys Lys Thr Val Trp His Ile Gln Phe Thr Ala Asp 945 950
955 960 Glu Lys Thr Leu Ile Ser Ser Ser Asp Asp Ala Glu Ile Gln Val
Trp 965 970 975 Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu Arg Gly His
Gln Glu Thr 980 985 990 Val Lys Asp Phe Arg Leu Leu Lys Asn Ser Arg
Leu Leu Ser Trp Ser 995 1000 1005 Phe Asp Gly Thr Val Lys Val Trp
Asn Ile Ile Thr Gly Asn Lys Glu 1010 1015 1020 Lys Asp Phe Val Cys
His Gln Gly Thr Val Leu Ser Cys Asp Ile Ser 1025 1030 1035 1040 His
Asp Ala Thr Lys Phe Ser Ser Thr Ser Ala Asp Lys Thr Ala Lys 1045
1050 1055 Ile Trp Ser Phe Asp Leu Leu Leu Pro Leu His Glu Leu Arg
Gly His 1060 1065 1070 Asn Gly Cys Val Arg Cys Ser Ala Phe Ser Val
Asp Ser Thr Leu Leu 1075 1080 1085 Ala Thr Gly Asp Asp Asn Gly Glu
Ile Arg Ile Trp Asn Val Ser Asn 1090 1095 1100 Gly Glu Leu Leu His
Leu Cys Ala Pro Leu Ser Glu Glu Gly Ala Ala 1105 1110 1115 1120 Thr
His Gly Gly Trp Val Thr Asp Leu Cys Phe Ser Pro Asp Gly Lys 1125
1130 1135 Met Leu Ile Ser Ala Gly Gly Tyr Ile Lys Trp Trp Asn Val
Val Thr 1140 1145 1150 Gly Glu Ser Ser Gln Thr Phe Tyr Thr Asn Gly
Thr Asn Leu Lys Lys 1155 1160 1165 Ile His Val Ser Pro Asp Phe Lys
Thr Tyr Val Thr Val Asp Asn Leu 1170 1175 1180 Gly Ile Leu Tyr Ile
Leu Gln Thr Leu Glu 1185 1190 <210> SEQ ID NO 51 <211>
LENGTH: 1248 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 51 Met Asp Ala Lys Ala Arg Asn Cys
Leu Leu Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp Ile Lys Thr
Ser Tyr Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly Phe Leu Thr
Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40 45 Gln Gln
Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 50 55 60
Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 65
70 75 80 Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val
Ser Ser 85 90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser
Tyr Val Arg Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro Gln Arg
Pro Val Val Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn Ala Ile
Gln Gln Lys Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly Trp Val
Thr Ile His Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser Val Leu
Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170 175 Cys
Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 180 185
190 Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu Asp Gln
195 200 205 Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu
Ala Lys 210 215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro
Arg Ser Leu Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp Ser Trp
Val Leu Lys Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu Leu Thr
Thr Arg Asp Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly Pro Lys
Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu Lys Gly
Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295 300 Asp
Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser 305 310
315 320 Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp Phe Pro
Asn 325 330 335 Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn Lys Gln
Phe Lys Arg 340 345 350 Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala
Leu Asp Glu Ala Met 355 360 365 Ser Ile Ser Val Glu Met Leu Arg Glu
Asp Ile Lys Asp Tyr Tyr Thr 370 375 380 Asp Leu Ser Ile Leu Gln Lys
Asp Val Lys Val Pro Thr Lys Val Leu 385 390 395 400 Cys Ile Leu Trp
Asp Met Glu Thr Glu Glu Val Glu Asp Ile Leu Gln 405 410 415 Glu Phe
Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 420 425 430
Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Thr Glu Lys
435 440 445 Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile Thr
Gln Phe 450 455 460 Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro Asp
Gln Glu Asp Cys 465 470 475 480 Met Tyr Trp Tyr Asn Phe Leu Ala Tyr
His Met Ala Ser Ala Lys Met 485 490 495 His Lys Glu Leu Cys Ala Leu
Met Phe Ser Leu Asp Trp Ile Lys Ala 500 505 510 Lys Thr Glu Leu Val
Gly Pro Ala His Leu Ile His Glu Phe Val Glu 515 520 525 Tyr Arg His
Ile Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 530 535 540 Gln
Glu Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 545 550
555 560 Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Thr Ser Glu
Val 565 570 575 Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val Asp
Asn Gly Met 580 585 590 Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile
Thr Asn Leu Ser Arg 595 600 605 Leu Val Val Arg Pro His Thr Asp Ala
Val Tyr His Ala Cys Phe Ser 610 615 620 Glu Asp Gly Gln Arg Ile Ala
Ser Cys Gly Ala Asp Lys Thr Leu Gln 625 630 635 640 Val Phe Lys Ala
Glu Thr Gly Glu Lys Leu Leu Glu Ile Lys Ala His 645 650 655 Glu Asp
Glu Val Leu Cys Cys Ala Phe Ser Thr Asp Asp Arg Phe Ile 660 665 670
Ala Thr Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Thr 675
680 685 Gly Glu Leu Val His Thr Tyr Asp Glu His Ser Glu Gln Val Asn
Cys 690 695 700 Cys His Phe Thr Asn Ser Ser His His Leu Leu Leu Ala
Thr Gly Ser 705 710 715 720 Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu
Asn Gln Lys Glu Cys Arg 725 730 735 Asn Thr Met Phe Gly His Thr Asn
Ser Val Asn His Cys Arg Phe Ser 740 745 750 Pro Asp Asp Lys Leu Leu
Ala Ser Cys Ser Ala Asp Gly Thr Leu Lys 755 760 765 Leu Trp Asp Ala
Thr Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 770 775 780 Gln Phe
Phe Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 785 790 795
800 Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val Ala
805 810 815 Ala Lys Asn Lys Ile Phe Leu Phe Asp Ile His Thr Ser Gly
Leu Leu 820 825 830 Gly Glu Ile His Thr Gly His His Ser Thr Ile Gln
Tyr Cys Asp Phe 835 840 845 Ser Pro Gln Asn His Leu Ala Val Val Ala
Leu Ser Gln Tyr Cys Val 850 855 860 Glu Leu Trp Asn Thr Asp Ser Arg
Ser Lys Val Ala Asp Cys Arg Gly 865 870 875 880 His Leu Ser Trp Val
His Gly Val Met Phe Ser Pro Asp Gly Ser Ser 885 890 895 Phe Leu Thr
Ser Ser Asp Asp Gln Thr Ile Arg Leu Trp Glu Thr Lys 900 905 910 Lys
Val Cys Lys Asn Ser Ala Val Met Leu Lys Gln Glu Val Asp Val 915 920
925 Val Phe Gln Glu Asn Glu Val Met Val Leu Ala Val Asp His Ile Arg
930 935 940 Arg Leu Gln Leu Ile Asn Gly Arg Thr Gly Gln Ile Asp Tyr
Leu Thr 945 950 955 960 Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro
His Leu Gln Tyr Ile 965 970 975 Ala Phe Gly Asp Glu Asn Gly Ala Ile
Glu Ile Leu Glu Leu Val Asn 980 985 990 Asn Arg Ile Phe Gln Ser Arg
Phe Gln His Lys Lys Thr Val Trp His 995 1000 1005 Ile Gln Phe Thr
Ala Asp Glu Lys Thr Leu Ile Ser Ser Ser Asp Asp 1010 1015 1020 Ala
Glu Ile Gln Val Trp Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu 1025
1030 1035 1040 Arg Gly His Gln Glu Thr Val Lys Asp Phe Arg Leu Leu
Lys Asn Ser 1045 1050 1055 Arg Leu Leu Ser Trp Ser Phe Asp Gly Thr
Val Lys Val Trp Asn Ile 1060 1065 1070 Ile Thr Gly Asn Lys Glu Lys
Asp Phe Val Cys His Gln Gly Thr Val 1075 1080 1085 Leu Ser Cys Asp
Ile Ser His Asp Ala Thr Lys Phe Ser Ser Thr Ser 1090 1095 1100 Ala
Asp Lys Thr Ala Lys Ile Trp Ser Phe Asp Leu Leu Leu Pro Leu 1105
1110 1115 1120 His Glu Leu Arg Gly His Asn Gly Cys Val Arg Cys Ser
Ala Phe Ser 1125 1130 1135 Val Asp Ser Thr Leu Leu Ala Thr Gly Asp
Asp Asn Gly Glu Ile Arg 1140 1145 1150 Ile Trp Asn Val Ser Asn Gly
Glu Leu Leu His Leu Cys Ala Pro Leu 1155 1160 1165 Ser Glu Glu Gly
Ala Ala Thr His Gly Gly Trp Val Thr Asp Leu Cys 1170 1175 1180 Phe
Ser Pro Asp Gly Lys Met Leu Ile Ser Ala Gly Gly Tyr Ile Lys 1185
1190 1195 1200 Trp Trp Asn Val Val Thr Gly Glu Ser Ser Gln Thr Phe
Tyr Thr Asn 1205 1210 1215 Gly Thr Asn Leu Lys Lys Ile His Val Ser
Pro Asp Phe Lys Thr Tyr 1220 1225 1230 Val Thr Val Asp Asn Leu Gly
Ile Leu Tyr Ile Leu Gln Thr Leu Glu 1235 1240 1245 <210> SEQ
ID NO 52 <211> LENGTH: 1205 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 52 Met Asp Ala Lys Ala
Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp
Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly
Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40
45 Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp
50 55 60 Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu
Gly Tyr 65 70 75 80 Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro
Val Val Ser Ser 85 90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile
Thr Ser Tyr Val Arg Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro
Gln Arg Pro Val Val Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn
Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly
Trp Val Thr Ile His Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser
Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170
175 Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys
180 185 190 Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu
Asp Gln 195 200 205 Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile
Glu Glu Ala Lys 210 215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys
His Pro Arg Ser Leu Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp
Ser Trp Val Leu Lys Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu
Leu Thr Thr Arg Asp Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly
Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu
Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295
300 Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser
305 310 315 320 Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp
Phe Pro Asn 325 330 335 Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn
Lys Gln Phe Lys Arg 340 345 350 Ile Arg Lys Ser Ser Ser Tyr Asp Tyr
Glu Ala Leu Asp Glu Ala Met 355 360 365 Ser Ile Ser Val Glu Met Leu
Arg Glu Asp Ile Lys Asp Tyr Tyr Thr 370 375 380 Asp Leu Ser Ile Leu
Gln Lys Asp Val Lys Val Pro Thr Lys Val Leu 385 390 395 400 Cys Ile
Leu Trp Asp Met Glu Thr Glu Glu Val Glu Asp Ile Leu Gln 405 410 415
Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 420
425 430 Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Thr Glu
Lys 435 440 445 Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile
Thr Gln Phe 450 455 460 Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro
Asp Gln Glu Asp Cys 465 470 475 480 Met Tyr Trp Tyr Asn Phe Leu Ala
Tyr His Met Ala Ser Ala Lys Met
485 490 495 His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu Asp Trp Ile
Lys Ala 500 505 510 Lys Thr Glu Leu Val Gly Pro Ala His Leu Ile His
Glu Phe Val Glu 515 520 525 Tyr Arg His Ile Leu Asp Glu Lys Asp Cys
Ala Val Ser Glu Asn Phe 530 535 540 Gln Glu Phe Leu Ser Leu Asn Gly
His Leu Leu Gly Arg Gln Pro Phe 545 550 555 560 Pro Asn Ile Val Gln
Leu Gly Leu Cys Glu Pro Glu Thr Ser Glu Val 565 570 575 Tyr Gln Gln
Ala Lys Leu Gln Ala Lys Gln Glu Val Asp Asn Gly Met 580 585 590 Leu
Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile Thr Asn Leu Ser Arg 595 600
605 Leu Val Val Arg Pro His Thr Asp Ala Val Tyr His Ala Cys Phe Ser
610 615 620 Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala Asp Lys Thr
Leu Gln 625 630 635 640 Val Phe Lys Ala Glu Thr Gly Glu Lys Leu Leu
Glu Ile Lys Ala His 645 650 655 Glu Asp Glu Val Leu Cys Cys Ala Phe
Ser Thr Asp Asp Arg Phe Ile 660 665 670 Ala Thr Cys Ser Val Asp Lys
Lys Val Lys Ile Trp Asn Ser Met Thr 675 680 685 Gly Glu Leu Val His
Thr Tyr Asp Glu His Ser Glu Gln Val Asn Cys 690 695 700 Cys His Phe
Thr Asn Ser Ser His His Leu Leu Leu Ala Thr Gly Ser 705 710 715 720
Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn Gln Lys Glu Cys Arg 725
730 735 Asn Thr Met Phe Gly His Thr Asn Ser Val Asn His Cys Arg Phe
Ser 740 745 750 Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala Asp Gly
Thr Leu Lys 755 760 765 Leu Trp Asp Ala Thr Ser Ala Asn Glu Arg Lys
Ser Ile Asn Val Lys 770 775 780 Gln Phe Phe Leu Asn Leu Glu Asp Pro
Gln Glu Asp Met Glu Val Ile 785 790 795 800 Val Lys Cys Cys Ser Trp
Ser Ala Asp Gly Ala Arg Ile Met Val Ala 805 810 815 Ala Lys Asn Lys
Ile Phe Leu Trp Asn Thr Asp Ser Arg Ser Lys Val 820 825 830 Ala Asp
Cys Arg Gly His Leu Ser Trp Val His Gly Val Met Phe Ser 835 840 845
Pro Asp Gly Ser Ser Phe Leu Thr Ser Ser Asp Asp Gln Thr Ile Arg 850
855 860 Leu Trp Glu Thr Lys Lys Val Cys Lys Asn Ser Ala Val Met Leu
Lys 865 870 875 880 Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu Val
Met Val Leu Ala 885 890 895 Val Asp His Ile Arg Arg Leu Gln Leu Ile
Asn Gly Arg Thr Gly Gln 900 905 910 Ile Asp Tyr Leu Thr Glu Ala Gln
Val Ser Cys Cys Cys Leu Ser Pro 915 920 925 His Leu Gln Tyr Ile Ala
Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile 930 935 940 Leu Glu Leu Val
Asn Asn Arg Ile Phe Gln Ser Arg Phe Gln His Lys 945 950 955 960 Lys
Thr Val Trp His Ile Gln Phe Thr Ala Asp Glu Lys Thr Leu Ile 965 970
975 Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp Asn Trp Gln Leu Asp
980 985 990 Lys Cys Ile Phe Leu Arg Gly His Gln Glu Thr Val Lys Asp
Phe Arg 995 1000 1005 Leu Leu Lys Asn Ser Arg Leu Leu Ser Trp Ser
Phe Asp Gly Thr Val 1010 1015 1020 Lys Val Trp Asn Ile Ile Thr Gly
Asn Lys Glu Lys Asp Phe Val Cys 1025 1030 1035 1040 His Gln Gly Thr
Val Leu Ser Cys Asp Ile Ser His Asp Ala Thr Lys 1045 1050 1055 Phe
Ser Ser Thr Ser Ala Asp Lys Thr Ala Lys Ile Trp Ser Phe Asp 1060
1065 1070 Leu Leu Leu Pro Leu His Glu Leu Arg Gly His Asn Gly Cys
Val Arg 1075 1080 1085 Cys Ser Ala Phe Ser Val Asp Ser Thr Leu Leu
Ala Thr Gly Asp Asp 1090 1095 1100 Asn Gly Glu Ile Arg Ile Trp Asn
Val Ser Asn Gly Glu Leu Leu His 1105 1110 1115 1120 Leu Cys Ala Pro
Leu Ser Glu Glu Gly Ala Ala Thr His Gly Gly Trp 1125 1130 1135 Val
Thr Asp Leu Cys Phe Ser Pro Asp Gly Lys Met Leu Ile Ser Ala 1140
1145 1150 Gly Gly Tyr Ile Lys Trp Trp Asn Val Val Thr Gly Glu Ser
Ser Gln 1155 1160 1165 Thr Phe Tyr Thr Asn Gly Thr Asn Leu Lys Lys
Ile His Val Ser Pro 1170 1175 1180 Asp Phe Lys Thr Tyr Val Thr Val
Asp Asn Leu Gly Ile Leu Tyr Ile 1185 1190 1195 1200 Leu Gln Thr Leu
Glu 1205 <210> SEQ ID NO 53 <211> LENGTH: 338
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 53 Met Asp Ala Lys Ala Arg Asn Cys Leu Leu
Gln His Arg Glu Ala Leu 1 5 10 15 Glu Lys Asp Ile Lys Thr Ser Tyr
Ile Met Asp His Met Ile Ser Asp 20 25 30 Gly Phe Leu Thr Ile Ser
Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 35 40 45 Gln Gln Gln Arg
Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 50 55 60 Asn Asp
Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 65 70 75 80
Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 85
90 95 Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser Tyr Val Arg
Thr 100 105 110 Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro Val Val
Phe Val Thr 115 120 125 Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys
Leu Ser Lys Leu Lys 130 135 140 Gly Glu Pro Gly Trp Val Thr Ile His
Gly Met Ala Gly Cys Gly Lys 145 150 155 160 Ser Val Leu Ala Ala Glu
Ala Val Arg Asp His Ser Leu Leu Glu Gly 165 170 175 Cys Phe Pro Gly
Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 180 185 190 Ser Gly
Leu Leu Met Lys Leu Gln Asn Leu Cys Thr Arg Leu Asp Gln 195 200 205
Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu Ala Lys 210
215 220 Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro Arg Ser Leu
Leu 225 230 235 240 Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu Lys
Ala Phe Asp Ser 245 250 255 Gln Cys Gln Ile Leu Leu Thr Thr Arg Asp
Lys Ser Val Thr Asp Ser 260 265 270 Val Met Gly Pro Lys Tyr Val Val
Pro Val Glu Ser Ser Leu Gly Lys 275 280 285 Glu Lys Gly Leu Glu Ile
Leu Ser Leu Phe Val Asn Met Lys Lys Ala 290 295 300 Asp Leu Pro Glu
Gln Ala His Ser Ile Ile Lys Glu Cys Lys Val Val 305 310 315 320 Glu
Arg Cys His Trp Gly Ile Leu Thr Asp Leu Leu His Lys Trp Asn 325 330
335 Gln Ser <210> SEQ ID NO 54 <211> LENGTH: 281
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 54 Met Ala Met Met Glu Val Gln Gly Gly Pro
Ser Leu Gly Gln Thr Cys 1 5 10 15 Val Leu Ile Val Ile Phe Thr Val
Leu Leu Gln Ser Leu Cys Val Ala 20 25 30 Val Thr Tyr Val Tyr Phe
Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 35 40 45 Tyr Ser Lys Ser
Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 50 55 60 Trp Asp
Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 65 70 75 80
Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 85
90 95 Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser
Pro 100 105 110 Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His
Ile Thr Gly 115 120 125 Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro
Asn Ser Lys Asn Glu 130 135 140 Lys Ala Leu Gly Arg Lys Ile Asn Ser
Trp Glu Ser Ser Arg Ser Gly 145 150 155 160 His Ser Phe Leu Ser Asn
Leu His Leu Arg Asn Gly Glu Leu Val Ile 165 170 175
His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 180
185 190 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val
Gln 195 200 205 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu
Leu Met Lys 210 215 220 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala
Glu Tyr Gly Leu Tyr 225 230 235 240 Ser Ile Tyr Gln Gly Gly Ile Phe
Glu Leu Lys Glu Asn Asp Arg Ile 245 250 255 Phe Val Ser Val Thr Asn
Glu His Leu Ile Asp Met Asp His Glu Ala 260 265 270 Ser Phe Phe Gly
Ala Phe Leu Val Gly 275 280 <210> SEQ ID NO 55 <211>
LENGTH: 277 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 55 Met Glu Asn Thr Glu Asn Ser Val
Asp Ser Lys Ser Ile Lys Asn Leu 1 5 10 15 Glu Pro Lys Ile Ile His
Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 20 25 30 Leu Asp Asn Ser
Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 35 40 45 Ile Ile
Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 50 55 60
Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 65
70 75 80 Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu
Glu Ile 85 90 95 Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His
Ser Lys Arg Ser 100 105 110 Ser Phe Val Cys Val Leu Leu Ser His Gly
Glu Glu Gly Ile Ile Phe 115 120 125 Gly Thr Asn Gly Pro Val Asp Leu
Lys Lys Ile Thr Asn Phe Phe Arg 130 135 140 Gly Asp Arg Cys Arg Ser
Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 145 150 155 160 Gln Ala Cys
Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 165 170 175 Gly
Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 180 185
190 Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn
195 200 205 Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met
Leu Lys 210 215 220 Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu
Thr Arg Val Asn 225 230 235 240 Arg Lys Val Ala Thr Glu Phe Glu Ser
Phe Ser Phe Asp Ala Thr Phe 245 250 255 His Ala Lys Lys Gln Ile Pro
Cys Ile Val Ser Met Leu Thr Lys Glu 260 265 270 Leu Tyr Phe Tyr His
275 <210> SEQ ID NO 56 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
56 Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser
1 5 10 15 Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe
Ile Gln 20 25 30 Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu
Leu Ala Leu Asp 35 40 45 Pro Val Pro Gln Asp Ala Ser Thr Lys Lys
Leu Ser Glu Cys Leu Lys 50 55 60 Arg Ile Gly Asp Glu Leu Asp Ser
Asn Met Glu Leu Gln Arg Met Ile 65 70 75 80 Ala Ala Val Asp Thr Asp
Ser Pro Arg Glu Val Phe Phe Arg Val Ala 85 90 95 Ala Asp Met Phe
Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 100 105 110 Leu Phe
Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 115 120 125
Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 130
135 140 Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp
Gly 145 150 155 160 Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr
Val Thr Ile Phe 165 170 175 Val Ala Gly Val Leu Thr Ala Ser Leu Thr
Ile Trp Lys Lys Met Gly 180 185 190 <210> SEQ ID NO 57
<211> LENGTH: 168 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 57 Met Phe Gln Ile Pro Glu Phe
Glu Pro Ser Glu Gln Glu Asp Ser Ser 1 5 10 15 Ser Ala Glu Arg Gly
Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 20 25 30 Gly Ser Gly
Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 35 40 45 Ser
His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 50 55
60 Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr
65 70 75 80 Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg
Gly Arg 85 90 95 Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln
Arg Tyr Gly Arg 100 105 110 Glu Leu Arg Arg Met Ser Asp Glu Phe Val
Asp Ser Phe Lys Lys Gly 115 120 125 Leu Pro Arg Pro Lys Ser Ala Gly
Thr Ala Thr Gln Met Arg Gln Ser 130 135 140 Ser Ser Trp Thr Arg Val
Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 145 150 155 160 Arg Gly Ser
Ser Ala Pro Ser Gln 165 <210> SEQ ID NO 58 <211>
LENGTH: 208 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 58 Met Asp Pro Phe Leu Val Leu Leu
His Ser Val Ser Ser Ser Leu Ser 1 5 10 15 Ser Ser Glu Leu Thr Glu
Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 20 25 30 Lys Arg Lys Leu
Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 35 40 45 Leu Leu
Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 50 55 60
Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 65
70 75 80 Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu
Glu Asp 85 90 95 Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val
Gly Lys Asp Trp 100 105 110 Arg Arg Leu Ala Arg Gln Leu Lys Val Ser
Asp Thr Lys Ile Asp Ser 115 120 125 Ile Glu Asp Arg Tyr Pro Arg Asn
Leu Thr Glu Arg Val Arg Glu Ser 130 135 140 Leu Arg Ile Trp Lys Asn
Thr Glu Lys Glu Asn Ala Thr Val Ala His 145 150 155 160 Leu Val Gly
Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 165 170 175 Val
Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 180 185
190 Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser
195 200 205 <210> SEQ ID NO 59 <211> LENGTH: 384
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 59 Met Ser Arg Ser Lys Arg Asp Asn Asn Phe
Tyr Ser Val Glu Ile Gly 1 5 10 15 Asp Ser Thr Phe Thr Val Leu Lys
Arg Tyr Gln Asn Leu Lys Pro Ile 20 25 30 Gly Ser Gly Ala Gln Gly
Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 35 40 45 Glu Arg Asn Val
Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 50 55 60 Thr His
Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 65 70 75 80
Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 85
90 95 Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met
Asp 100 105 110 Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His
Glu Arg Met 115 120 125 Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile
Lys His Leu His Ser 130 135 140 Ala Gly Ile Ile His Arg Asp Leu Lys
Pro Ser Asn Ile Val Val Lys
145 150 155 160 Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala
Arg Thr Ala 165 170 175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val
Thr Arg Tyr Tyr Arg 180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly
Tyr Lys Glu Asn Val Asp Leu 195 200 205 Trp Ser Val Gly Cys Ile Met
Gly Glu Met Val Cys His Lys Ile Leu 210 215 220 Phe Pro Gly Arg Asp
Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly
Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255
Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260
265 270 Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn
Lys 275 280 285 Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met
Leu Val Ile 290 295 300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala
Leu Gln His Pro Tyr 305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser
Glu Ala Glu Ala Pro Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu
Asp Glu Arg Glu His Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile
Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly
Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 370 375 380
<210> SEQ ID NO 60 <211> LENGTH: 427 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 60 Met
Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10
15 Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile
20 25 30 Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala
Ile Leu 35 40 45 Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro
Phe Gln Asn Gln 50 55 60 Thr His Ala Lys Arg Ala Tyr Arg Glu Leu
Val Leu Met Lys Cys Val 65 70 75 80 Asn His Lys Asn Ile Ile Gly Leu
Leu Asn Val Phe Thr Pro Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln
Asp Val Tyr Ile Val Met Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys
Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 115 120 125 Ser Tyr
Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 130 135 140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145
150 155 160 Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg
Thr Ala 165 170 175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr
Arg Tyr Tyr Arg 180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr
Lys Glu Asn Val Asp Leu 195 200 205 Trp Ser Val Gly Cys Ile Met Gly
Glu Met Val Cys His Lys Ile Leu 210 215 220 Phe Pro Gly Arg Asp Tyr
Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly Thr
Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg
Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265
270 Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys
275 280 285 Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu
Val Ile 290 295 300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu
Gln His Pro Tyr 305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu
Ala Glu Ala Pro Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp
Glu Arg Glu His Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr
Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val
Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 370 375 380 Asn
Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 385 390
395 400 Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser
Leu 405 410 415 Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 420 425
<210> SEQ ID NO 61 <211> LENGTH: 384 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 61 Met
Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10
15 Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile
20 25 30 Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala
Ile Leu 35 40 45 Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro
Phe Gln Asn Gln 50 55 60 Thr His Ala Lys Arg Ala Tyr Arg Glu Leu
Val Leu Met Lys Cys Val 65 70 75 80 Asn His Lys Asn Ile Ile Gly Leu
Leu Asn Val Phe Thr Pro Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln
Asp Val Tyr Ile Val Met Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys
Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 115 120 125 Ser Tyr
Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 130 135 140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145
150 155 160 Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg
Thr Ala 165 170 175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr
Arg Tyr Tyr Arg 180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr
Lys Glu Asn Val Asp Ile 195 200 205 Trp Ser Val Gly Cys Ile Met Gly
Glu Met Ile Lys Gly Gly Val Leu 210 215 220 Phe Pro Gly Thr Asp His
Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly Thr
Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg
Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265
270 Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys
275 280 285 Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu
Val Ile 290 295 300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu
Gln His Pro Tyr 305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu
Ala Glu Ala Pro Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp
Glu Arg Glu His Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr
Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val
Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 370 375 380
<210> SEQ ID NO 62 <211> LENGTH: 427 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 62 Met
Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 1 5 10
15 Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile
20 25 30 Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala
Ile Leu 35 40 45 Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro
Phe Gln Asn Gln 50 55 60 Thr His Ala Lys Arg Ala Tyr Arg Glu Leu
Val Leu Met Lys Cys Val 65 70 75 80 Asn His Lys Asn Ile Ile Gly Leu
Leu Asn Val Phe Thr Pro Gln Lys 85 90 95 Ser Leu Glu Glu Phe Gln
Asp Val Tyr Ile Val Met Glu Leu Met Asp 100 105 110 Ala Asn Leu Cys
Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 115 120 125 Ser Tyr
Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 130 135 140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 145
150 155 160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 165
170 175 Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr
Arg 180 185 190 Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn
Val Asp Ile 195 200 205 Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile
Lys Gly Gly Val Leu 210 215 220 Phe Pro Gly Thr Asp His Ile Asp Gln
Trp Asn Lys Val Ile Glu Gln 225 230 235 240 Leu Gly Thr Pro Cys Pro
Glu Phe Met Lys Lys Leu Gln Pro Thr Val 245 250 255 Arg Thr Tyr Val
Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 260 265 270 Lys Leu
Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 275 280 285
Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 290
295 300 Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro
Tyr 305 310 315 320 Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala
Pro Pro Pro Lys 325 330 335 Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu
His Thr Ile Glu Glu Trp 340 345 350 Lys Glu Leu Ile Tyr Lys Glu Val
Met Asp Leu Glu Glu Arg Thr Lys 355 360 365 Asn Gly Val Ile Arg Gly
Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 370 375 380 Asn Gly Ser Gln
His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 385 390 395 400 Ser
Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 405 410
415 Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 420 425 <210>
SEQ ID NO 63 <211> LENGTH: 360 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 63 Met Ser
Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 1 5 10 15
Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 20
25 30 Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly
Leu 35 40 45 Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser
Ile Ile His 50 55 60 Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu
Lys His Met Lys His 65 70 75 80 Glu Asn Val Ile Gly Leu Leu Asp Val
Phe Thr Pro Ala Arg Ser Leu 85 90 95 Glu Glu Phe Asn Asp Val Tyr
Leu Val Thr His Leu Met Gly Ala Asp 100 105 110 Leu Asn Asn Ile Val
Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 115 120 125 Phe Leu Ile
Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 130 135 140 Asp
Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 145 150
155 160 Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr
Asp 165 170 175 Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg
Ala Pro Glu 180 185 190 Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr
Val Asp Ile Trp Ser 195 200 205 Val Gly Cys Ile Met Ala Glu Leu Leu
Thr Gly Arg Thr Leu Phe Pro 210 215 220 Gly Thr Asp His Ile Asn Gln
Leu Gln Gln Ile Met Arg Leu Thr Gly 225 230 235 240 Thr Pro Pro Ala
Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 245 250 255 Asn Tyr
Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 260 265 270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 275
280 285 Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu
Ala 290 295 300 His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu
Pro Val Ala 305 310 315 320 Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg
Asp Leu Leu Ile Asp Glu 325 330 335 Trp Lys Ser Leu Thr Tyr Asp Glu
Val Ile Ser Phe Val Pro Pro Pro 340 345 350 Leu Asp Gln Glu Glu Met
Glu Ser 355 360 <210> SEQ ID NO 64 <211> LENGTH: 240
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 64 Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile
Gly Glu Gly Thr Tyr Gly 1 5 10 15 Val Val Tyr Lys Gly Arg His Lys
Thr Thr Gly Gln Val Val Ala Met 20 25 30 Lys Lys Ile Arg Leu Glu
Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 35 40 45 Ile Arg Glu Ile
Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 50 55 60 Ser Leu
Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 65 70 75 80
Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 85
90 95 Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Val Val Thr Leu Trp
Tyr 100 105 110 Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser
Thr Pro Val 115 120 125 Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu
Leu Ala Thr Lys Lys 130 135 140 Pro Leu Phe His Gly Asp Ser Glu Ile
Asp Gln Leu Phe Arg Ile Phe 145 150 155 160 Arg Ala Leu Gly Thr Pro
Asn Asn Glu Val Trp Pro Glu Val Glu Ser 165 170 175 Leu Gln Asp Tyr
Lys Asn Thr Phe Pro Lys Trp Lys Pro Gly Ser Leu 180 185 190 Ala Ser
His Val Lys Asn Leu Asp Glu Asn Gly Leu Asp Leu Leu Ser 195 200 205
Lys Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile Ser Gly Lys Met Ala 210
215 220 Leu Asn His Pro Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys
Met 225 230 235 240 <210> SEQ ID NO 65 <211> LENGTH:
432 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 65 Met Leu Gly Asn Ser Ala Pro Gly Pro Ala
Thr Arg Glu Ala Gly Ser 1 5 10 15 Ala Leu Leu Ala Leu Gln Gln Thr
Ala Leu Gln Glu Asp Gln Glu Asn 20 25 30 Ile Asn Pro Glu Lys Ala
Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 35 40 45 Ala Leu Ala Val
Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 50 55 60 Gln Arg
Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 65 70 75 80
Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 85
90 95 Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln
Lys 100 105 110 Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala
Leu Ala Phe 115 120 125 Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys
Pro Leu Val Pro Leu 130 135 140 Asp Tyr Pro Met Asp Gly Ser Phe Glu
Ser Pro His Thr Met Asp Met 145 150 155 160 Ser Ile Val Leu Glu Asp
Glu Lys Pro Val Ser Val Asn Glu Val Pro 165 170 175 Asp Tyr His Glu
Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 180 185 190 Cys Lys
Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 195 200 205
Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 210
215 220 Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile
Asp 225 230 235 240 Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys
Leu Gln Leu Val 245 250 255 Gly Thr Ala Ala Met Leu Leu Ala Ser Lys
Phe Glu Glu Ile Tyr Pro 260 265 270 Pro Glu Val Ala Glu Phe Val Tyr
Ile Thr Asp Asp Thr Tyr Thr Lys 275 280 285 Lys Gln Val Leu Arg Met
Glu His Leu Val Leu Lys Val Leu Thr Phe 290 295 300 Asp Leu Ala Ala
Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 305 310 315 320 His
Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 325 330
335
Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 340
345 350 Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val
Thr 355 360 365 Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly
Tyr Thr Leu 370 375 380 Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His
Gln Thr Tyr Leu Lys 385 390 395 400 Ala Pro Gln His Ala Gln Gln Ser
Ile Arg Glu Lys Tyr Lys Asn Ser 405 410 415 Lys Tyr His Gly Val Ser
Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 420 425 430 <210> SEQ
ID NO 66 <211> LENGTH: 289 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 66 Met Glu Leu Leu Cys
His Glu Val Asp Pro Val Arg Arg Ala Val Arg 1 5 10 15 Asp Arg Asn
Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 20 25 30 Ile
Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 35 40
45 Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
50 55 60 Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro
Leu Ala 65 70 75 80 Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro
Thr Pro Lys Ser 85 90 95 His Leu Gln Leu Leu Gly Ala Val Cys Met
Phe Leu Ala Ser Lys Leu 100 105 110 Lys Glu Thr Ser Pro Leu Thr Ala
Glu Lys Leu Cys Ile Tyr Thr Asp 115 120 125 Asn Ser Ile Lys Pro Gln
Glu Leu Leu Glu Trp Glu Leu Val Val Leu 130 135 140 Gly Lys Leu Lys
Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile 145 150 155 160 Glu
His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 165 170
175 Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
180 185 190 Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser
Val Gly 195 200 205 Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val
Ser Ser Leu Thr 210 215 220 Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys
Ile Thr Asn Thr Asp Val 225 230 235 240 Asp Cys Leu Lys Ala Cys Gln
Glu Gln Ile Glu Ala Val Leu Leu Asn 245 250 255 Ser Leu Gln Gln Tyr
Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu 260 265 270 Asp Glu Leu
Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 275 280 285 Leu
<210> SEQ ID NO 67 <211> LENGTH: 292 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 67 Met
Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 1 5 10
15 Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu
20 25 30 Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln
Cys Val 35 40 45 Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu
Ala Tyr Trp Met 50 55 60 Leu Glu Val Cys Glu Glu Gln Arg Cys Glu
Glu Glu Val Phe Pro Leu 65 70 75 80 Ala Met Asn Tyr Leu Asp Arg Tyr
Leu Ser Cys Val Pro Thr Arg Lys 85 90 95 Ala Gln Leu Gln Leu Leu
Gly Ala Val Cys Met Leu Leu Ala Ser Lys 100 105 110 Leu Arg Glu Thr
Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 115 120 125 Asp His
Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 130 135 140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 145
150 155 160 Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg
Gln Ala 165 170 175 Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu
Cys Ala Thr Asp 180 185 190 Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met
Ile Ala Thr Gly Ser Ile 195 200 205 Gly Ala Ala Val Gln Gly Leu Gly
Ala Cys Ser Met Ser Gly Asp Glu 210 215 220 Leu Thr Glu Leu Leu Ala
Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 225 230 235 240 Arg Ala Cys
Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 245 250 255 Glu
Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 260 265
270 Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr
275 280 285 Ala Ile His Leu 290 <210> SEQ ID NO 68
<211> LENGTH: 410 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 68 Met Pro Arg Glu Arg Arg Glu
Arg Asp Ala Lys Glu Arg Asp Thr Met 1 5 10 15 Lys Glu Asp Gly Gly
Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 20 25 30 Ala Asn Val
Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 35 40 45 Ile
Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 50 55
60 Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys
65 70 75 80 Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro
Arg Ile 85 90 95 Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu
Ser Trp Ala Asn 100 105 110 Arg Glu Glu Val Trp Lys Ile Met Leu Asn
Lys Glu Lys Thr Tyr Leu 115 120 125 Arg Asp Gln His Phe Leu Glu Gln
His Pro Leu Leu Gln Pro Lys Met 130 135 140 Arg Ala Ile Leu Leu Asp
Trp Leu Met Glu Val Cys Glu Val Tyr Lys 145 150 155 160 Leu His Arg
Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 165 170 175 Met
Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 180 185
190 Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro
195 200 205 Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser
Gly Asp 210 215 220 Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala
Leu Lys Trp Arg 225 230 235 240 Leu Ser Pro Leu Thr Ile Val Ser Trp
Leu Asn Val Tyr Met Gln Val 245 250 255 Ala Tyr Leu Asn Asp Leu His
Glu Val Leu Leu Pro Gln Tyr Pro Gln 260 265 270 Gln Ile Phe Ile Gln
Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 275 280 285 Val Asp Cys
Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 290 295 300 Tyr
His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 305 310
315 320 Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala
Met 325 330 335 Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe
Arg Gly Val 340 345 350 Ala Asp Glu Asp Ala His Asn Ile Gln Thr His
Arg Asp Ser Leu Asp 355 360 365 Leu Leu Asp Lys Ala Arg Ala Lys Lys
Ala Met Leu Ser Glu Gln Asn 370 375 380 Arg Ala Ser Pro Leu Pro Ser
Gly Leu Leu Thr Pro Pro Gln Ser Gly 385 390 395 400 Lys Lys Gln Ser
Ser Gly Pro Glu Met Ala 405 410 <210> SEQ ID NO 69
<211> LENGTH: 473 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 69 Met Ser Thr Glu Leu Phe Ser
Ser Thr Arg Glu Glu Gly Ser Ser Gly 1 5 10 15 Ser Gly Pro Ser Phe
Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 20 25 30 Leu Glu Arg
Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 35 40 45 Pro
Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser
50 55 60 Gly Gly Thr Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser
Ser Gly 65 70 75 80 Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp
Leu Asp Glu Thr 85 90 95 Gly His Leu Asp Ser Ser Gly Leu Gln Glu
Val His Leu Ala Gly Met 100 105 110 Asn His Asp Gln His Leu Met Lys
Cys Ser Pro Ala Gln Leu Leu Cys 115 120 125 Ser Thr Pro Asn Gly Leu
Asp Arg Gly His Arg Lys Arg Asp Ala Met 130 135 140 Cys Ser Ser Ser
Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 145 150 155 160 Ser
Glu Met Lys Tyr Leu Gly Ser Pro Ile Thr Thr Val Pro Lys Leu 165 170
175 Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp
180 185 190 Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val
Ser Arg 195 200 205 Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn
Leu Asn Arg Pro 210 215 220 Arg Leu Lys Gln Val Glu Lys Phe Lys Asp
Asn Thr Ile Pro Asp Lys 225 230 235 240 Val Lys Lys Lys Tyr Phe Ser
Gly Gln Gly Lys Leu Arg Lys Gly Leu 245 250 255 Cys Leu Lys Lys Thr
Val Ser Leu Cys Asp Ile Thr Ile Thr Gln Met 260 265 270 Leu Glu Glu
Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 275 280 285 Val
Cys Ala Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 290 295
300 Val Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly
305 310 315 320 Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro
Tyr Glu Tyr 325 330 335 Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu
Tyr Ser Gln Glu Glu 340 345 350 Leu Phe Asn Phe Phe Leu Lys Lys Pro
Ile Val Pro Leu Asp Thr Gln 355 360 365 Lys Arg Ile Ile Ile Val Phe
His Cys Glu Phe Ser Ser Glu Arg Gly 370 375 380 Pro Arg Met Cys Arg
Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 385 390 395 400 Tyr Pro
Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 405 410 415
Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 420
425 430 Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys
Arg 435 440 445 Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg
Glu Gln Ile 450 455 460 Ala Leu Leu Val Lys Asp Met Ser Pro 465 470
<210> SEQ ID NO 70 <211> LENGTH: 400 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met
Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 1 5 10
15 Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu
20 25 30 Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro
Arg Thr 35 40 45 Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu
Ser Ile Leu Ser 50 55 60 Gly Ser Pro Gly Phe Phe Arg Thr Ser Gly
Ser Ala Phe Ser Trp Asp 65 70 75 80 Asp Asn Gly Asn Leu Val Asp Ser
Glu Met Lys Tyr Leu Gly Ser Pro 85 90 95 Ile Thr Thr Val Pro Lys
Leu Asp Lys Asn Pro Asn Leu Gly Glu Asp 100 105 110 Gln Ala Glu Glu
Ile Ser Asp Glu Leu Met Glu Phe Ser Leu Lys Asp 115 120 125 Gln Glu
Ala Lys Val Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met 130 135 140
Pro Glu Asn Leu Asn Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys 145
150 155 160 Asp Asn Thr Ile Pro Asp Lys Val Lys Lys Lys Tyr Phe Ser
Gly Gln 165 170 175 Gly Lys Leu Arg Lys Gly Leu Cys Leu Lys Lys Thr
Val Ser Leu Cys 180 185 190 Asp Ile Thr Ile Thr Gln Met Leu Glu Glu
Asp Ser Asn Gln Gly His 195 200 205 Leu Ile Gly Asp Phe Ser Lys Val
Cys Ala Leu Pro Thr Val Ser Gly 210 215 220 Lys His Gln Asp Leu Lys
Tyr Val Asn Pro Glu Thr Val Ala Ala Leu 225 230 235 240 Leu Ser Gly
Lys Phe Gln Gly Leu Ile Glu Lys Phe Tyr Val Ile Asp 245 250 255 Cys
Arg Tyr Pro Tyr Glu Tyr Leu Gly Gly His Ile Gln Gly Ala Leu 260 265
270 Asn Leu Tyr Ser Gln Glu Glu Leu Phe Asn Phe Phe Leu Lys Lys Pro
275 280 285 Ile Val Pro Leu Asp Thr Gln Lys Arg Ile Ile Ile Val Phe
His Cys 290 295 300 Glu Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg
Cys Leu Arg Glu 305 310 315 320 Glu Asp Arg Ser Leu Asn Gln Tyr Pro
Ala Leu Tyr Tyr Pro Glu Leu 325 330 335 Tyr Ile Leu Lys Gly Gly Tyr
Arg Asp Phe Phe Pro Glu Tyr Met Glu 340 345 350 Leu Cys Glu Pro Gln
Ser Tyr Cys Pro Met His His Gln Asp His Lys 355 360 365 Thr Glu Leu
Leu Arg Cys Arg Ser Gln Ser Lys Val Gln Glu Gly Glu 370 375 380 Arg
Gln Leu Arg Glu Gln Ile Ala Leu Leu Val Lys Asp Met Ser Pro 385 390
395 400 <210> SEQ ID NO 71 <211> LENGTH: 164
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 71 Met Ser Glu Pro Ala Gly Asp Val Arg Gln
Asn Pro Cys Gly Ser Lys 1 5 10 15 Ala Cys Arg Arg Leu Phe Gly Pro
Val Asp Ser Glu Gln Leu Ser Arg 20 25 30 Asp Cys Asp Ala Leu Met
Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 35 40 45 Trp Asn Phe Asp
Phe Val Thr Glu Thr Pro Leu Glu Gly Asp Phe Ala 50 55 60 Trp Glu
Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Thr 65 70 75 80
Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 85
90 95 Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His Val
Asp 100 105 110 Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu
Gln Ala Glu 115 120 125 Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly
Arg Lys Arg Arg Gln 130 135 140 Thr Ser Met Thr Asp Phe Tyr His Ser
Lys Arg Arg Leu Ile Phe Ser 145 150 155 160 Lys Arg Lys Pro
<210> SEQ ID NO 72 <211> LENGTH: 156 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met
Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 1 5 10
15 Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
20 25 30 Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg
Arg Pro 35 40 45 Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala
Glu Leu Leu Leu 50 55 60 Leu His Gly Ala Glu Pro Asn Cys Ala Asp
Pro Ala Thr Leu Thr Arg 65 70 75 80 Pro Val His Asp Ala Ala Arg Glu
Gly Phe Leu Asp Thr Leu Val Val 85 90 95 Leu His Arg Ala Gly Ala
Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 100 105 110 Leu Pro Val Asp
Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 115 120 125 Tyr Leu
Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 130 135 140
Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 145 150 155
<210> SEQ ID NO 73 <211> LENGTH: 116 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 73 Met
Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 1 5 10
15
Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 20
25 30 Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg
Pro 35 40 45 Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly Asp
Gly Gly Arg 50 55 60 Leu Trp Arg Thr Lys Phe Ala Gly Glu Leu Glu
Ser Gly Ser Ala Ser 65 70 75 80 Ile Leu Arg Lys Lys Gly Arg Leu Pro
Gly Glu Phe Ser Glu Gly Val 85 90 95 Cys Asn His Arg Pro Pro Pro
Gly Asp Ala Leu Gly Ala Trp Glu Ala 100 105 110 Lys Glu Glu Glu 115
<210> SEQ ID NO 74 <211> LENGTH: 173 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 74 Met
Gly Arg Gly Arg Cys Val Gly Pro Ser Leu Gln Leu Arg Gly Gln 1 5 10
15 Glu Trp Arg Cys Ser Pro Leu Val Pro Lys Gly Gly Ala Ala Ala Ala
20 25 30 Glu Leu Gly Pro Gly Gly Gly Glu Asn Met Val Arg Arg Phe
Leu Val 35 40 45 Thr Leu Arg Ile Arg Arg Ala Cys Gly Pro Pro Arg
Val Arg Val Phe 50 55 60 Val Val His Ile Pro Arg Leu Thr Gly Glu
Trp Ala Ala Pro Gly Ala 65 70 75 80 Pro Ala Ala Val Ala Leu Val Leu
Met Leu Leu Arg Ser Gln Arg Leu 85 90 95 Gly Gln Gln Pro Leu Pro
Arg Arg Pro Gly His Asp Asp Gly Gln Arg 100 105 110 Pro Ser Gly Gly
Ala Ala Ala Ala Pro Arg Arg Gly Ala Gln Leu Arg 115 120 125 Arg Pro
Arg His Ser His Pro Thr Arg Ala Arg Arg Cys Pro Gly Gly 130 135 140
Leu Pro Gly His Ala Gly Gly Ala Ala Pro Gly Arg Gly Ala Ala Gly 145
150 155 160 Arg Ala Arg Cys Leu Gly Pro Ser Ala Arg Gly Pro Gly 165
170 <210> SEQ ID NO 75 <211> LENGTH: 298 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
75 Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly
1 5 10 15 Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val
Ala Leu 20 25 30 Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val
Pro Ser Thr Ala 35 40 45 Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu
Asn His Pro Asn Ile Val 50 55 60 Lys Leu Leu Asp Val Ile His Thr
Glu Asn Lys Leu Tyr Leu Val Phe 65 70 75 80 Glu Phe Leu His Gln Asp
Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 85 90 95 Thr Gly Ile Pro
Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 100 105 110 Gln Gly
Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 115 120 125
Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 130
135 140 Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr
Thr 145 150 155 160 His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu
Ile Leu Leu Gly 165 170 175 Cys Lys Tyr Tyr Ser Thr Ala Val Asp Ile
Trp Ser Leu Gly Cys Ile 180 185 190 Phe Ala Glu Met Val Thr Arg Arg
Ala Leu Phe Pro Gly Asp Ser Glu 195 200 205 Ile Asp Gln Leu Phe Arg
Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 210 215 220 Val Val Trp Pro
Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe 225 230 235 240 Pro
Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 245 250
255 Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn
260 265 270 Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe
Gln Asp 275 280 285 Val Thr Lys Pro Val Pro His Leu Arg Leu 290 295
<210> SEQ ID NO 76 <211> LENGTH: 264 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Met
Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 1 5 10
15 Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu
20 25 30 Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser
Thr Ala 35 40 45 Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His
Pro Asn Ile Val 50 55 60 Lys Leu Leu Asp Val Ile His Thr Glu Asn
Lys Leu Tyr Leu Val Phe 65 70 75 80 Glu Phe Leu His Gln Asp Leu Lys
Lys Phe Met Asp Ala Ser Ala Leu 85 90 95 Thr Gly Ile Pro Leu Pro
Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 100 105 110 Gln Gly Leu Ala
Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 115 120 125 Lys Pro
Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 130 135 140
Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 145
150 155 160 His Glu Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu
Ile Asp 165 170 175 Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro
Asp Glu Val Val 180 185 190 Trp Pro Gly Val Thr Ser Met Pro Asp Tyr
Lys Pro Ser Phe Pro Lys 195 200 205 Trp Ala Arg Gln Asp Phe Ser Lys
Val Val Pro Pro Leu Asp Glu Asp 210 215 220 Gly Arg Ser Leu Leu Ser
Gln Met Leu His Tyr Asp Pro Asn Lys Arg 225 230 235 240 Ile Ser Ala
Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp Val Thr 245 250 255 Lys
Pro Val Pro His Leu Arg Leu 260 <210> SEQ ID NO 77
<211> LENGTH: 303 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 77 Met Ala Thr Ser Arg Tyr Glu
Pro Val Ala Glu Ile Gly Val Gly Ala 1 5 10 15 Tyr Gly Thr Val Tyr
Lys Ala Arg Asp Pro His Ser Gly His Phe Val 20 25 30 Ala Leu Lys
Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 35 40 45 Leu
Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 50 55
60 Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr
65 70 75 80 Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu
His Val 85 90 95 Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro
Pro Pro Gly Leu 100 105 110 Pro Ala Glu Thr Ile Lys Asp Leu Met Arg
Gln Phe Leu Arg Gly Leu 115 120 125 Asp Phe Leu His Ala Asn Cys Ile
Val His Arg Asp Leu Lys Pro Glu 130 135 140 Asn Ile Leu Val Thr Ser
Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 145 150 155 160 Leu Ala Arg
Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 165 170 175 Thr
Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 180 185
190 Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe
195 200 205 Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln
Leu Gly 210 215 220 Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp
Asp Trp Pro Arg 225 230 235 240 Asp Val Ser Leu Pro Arg Gly Ala Phe
Pro Pro Arg Gly Pro Arg Pro 245 250 255 Val Gln Ser Val Val Pro Glu
Met Glu Glu Ser Gly Ala Gln Leu Leu 260 265 270 Leu Glu Met Leu Thr
Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 275 280 285 Ala Leu Gln
His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 290 295 300
<210> SEQ ID NO 78 <211> LENGTH: 326 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met
Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 1 5 10
15 Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp
20 25 30 Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg
Val Gln 35 40 45 Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg
Glu Val Ala Val 50 55 60 Leu Arg His Leu Glu Thr Phe Glu His Pro
Asn Val Val Arg Leu Phe 65 70 75 80 Asp Val Cys Thr Val Ser Arg Thr
Asp Arg Glu Thr Lys Leu Thr Leu 85 90 95 Val Phe Glu His Val Asp
Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 100 105 110 Pro Glu Pro Gly
Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 115 120 125 Leu Leu
Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 130 135 140
Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 145
150 155 160 Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met
Ala Leu 165 170 175 Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro
Glu Val Leu Leu 180 185 190 Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu
Trp Ser Val Gly Cys Ile 195 200 205 Phe Ala Glu Met Phe Arg Arg Lys
Pro Leu Phe Arg Gly Ser Ser Asp 210 215 220 Val Asp Gln Leu Gly Lys
Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 225 230 235 240 Glu Asp Trp
Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 245 250 255 Lys
Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 260 265
270 Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg
275 280 285 Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp
Leu Glu 290 295 300 Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro
Ser Gln Asn Thr 305 310 315 320 Ser Glu Leu Asn Thr Ala 325
<210> SEQ ID NO 79 <211> LENGTH: 437 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Met
Ala Leu Ala Gly Ala Pro Ala Gly Gly Pro Cys Ala Pro Ala Leu 1 5 10
15 Glu Ala Leu Leu Gly Ala Gly Ala Leu Arg Leu Leu Asp Ser Ser Gln
20 25 30 Ile Val Ile Ile Ser Ala Ala Gln Asp Ala Ser Ala Pro Pro
Ala Pro 35 40 45 Thr Gly Pro Ala Ala Pro Ala Ala Gly Pro Cys Asp
Pro Asp Leu Leu 50 55 60 Leu Phe Ala Thr Pro Gln Ala Pro Arg Pro
Thr Pro Ser Ala Pro Arg 65 70 75 80 Pro Ala Leu Gly Arg Pro Pro Val
Lys Arg Arg Leu Asp Leu Glu Thr 85 90 95 Asp His Gln Tyr Leu Ala
Glu Ser Ser Gly Pro Ala Arg Gly Arg Gly 100 105 110 Arg His Pro Gly
Lys Gly Val Lys Ser Pro Gly Glu Lys Ser Arg Tyr 115 120 125 Glu Thr
Ser Leu Asn Leu Thr Thr Lys Arg Phe Leu Glu Leu Leu Ser 130 135 140
His Ser Ala Asp Gly Val Val Asp Leu Asn Trp Ala Ala Glu Val Leu 145
150 155 160 Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu
Glu Gly 165 170 175 Ile Gln Leu Ile Ala Lys Lys Ser Lys Asn His Ile
Gln Trp Leu Gly 180 185 190 Ser His Thr Thr Val Gly Val Gly Gly Arg
Leu Glu Gly Leu Thr Gln 195 200 205 Asp Leu Arg Gln Leu Gln Glu Ser
Glu Gln Gln Leu Asp His Leu Met 210 215 220 Asn Ile Cys Thr Thr Gln
Leu Arg Leu Leu Ser Glu Asp Thr Asp Ser 225 230 235 240 Gln Arg Leu
Ala Tyr Val Thr Cys Gln Asp Leu Arg Ser Ile Ala Asp 245 250 255 Pro
Ala Glu Gln Met Val Met Val Ile Lys Ala Pro Pro Glu Thr Gln 260 265
270 Leu Gln Ala Val Asp Ser Ser Glu Asn Phe Gln Ile Ser Leu Lys Ser
275 280 285 Lys Gln Gly Pro Ile Asp Val Phe Leu Cys Pro Glu Glu Thr
Val Gly 290 295 300 Gly Ile Ser Pro Gly Lys Thr Pro Ser Gln Glu Val
Thr Ser Glu Glu 305 310 315 320 Glu Asn Arg Ala Thr Asp Ser Ala Thr
Ile Val Ser Pro Pro Pro Ser 325 330 335 Ser Pro Pro Ser Ser Leu Thr
Thr Asp Pro Ser Gln Ser Leu Leu Ser 340 345 350 Leu Glu Gln Glu Pro
Leu Leu Ser Arg Met Gly Ser Leu Arg Ala Pro 355 360 365 Val Asp Glu
Asp Arg Leu Ser Pro Leu Val Ala Ala Asp Ser Leu Leu 370 375 380 Glu
His Val Arg Glu Asp Phe Ser Gly Leu Leu Pro Glu Glu Phe Ile 385 390
395 400 Ser Leu Ser Pro Pro His Glu Ala Leu Asp Tyr His Phe Gly Leu
Glu 405 410 415 Glu Gly Glu Gly Ile Arg Asp Leu Phe Asp Cys Asp Phe
Gly Asp Leu 420 425 430 Thr Pro Leu Asp Phe 435 <210> SEQ ID
NO 80 <211> LENGTH: 1170 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Gly Leu Ala Trp
Gly Leu Gly Val Leu Phe Leu Met His Val Cys 1 5 10 15 Gly Thr Asn
Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 20 25 30 Ile
Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 35 40
45 Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala
50 55 60 Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu
Val Asp 65 70 75 80 Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala
Ser Leu Arg Gln 85 90 95 Met Lys Lys Thr Arg Gly Thr Leu Leu Ala
Leu Glu Arg Lys Asp His 100 105 110 Ser Gly Gln Val Phe Ser Val Val
Ser Asn Gly Lys Ala Gly Thr Leu 115 120 125 Asp Leu Ser Leu Thr Val
Gln Gly Lys Gln His Val Val Ser Val Glu 130 135 140 Glu Ala Leu Leu
Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 145 150 155 160 Gln
Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 165 170
175 Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala
180 185 190 Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp
Asn Phe 195 200 205 Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly
Thr Thr Pro Glu 210 215 220 Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser
Ser Thr Ser Val Leu Leu 225 230 235 240 Thr Leu Asp Asn Asn Val Val
Asn Gly Ser Ser Pro Ala Ile Arg Thr 245 250 255 Asn Tyr Ile Gly His
Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 260 265 270 Ser Cys Asp
Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 275 280 285 Thr
Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 290 295
300 Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His
305 310 315 320 Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val
Asp Ser Cys 325 330 335 Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile
Cys Lys Lys Val Ser 340 345 350 Cys Pro Ile Met Pro Cys Ser Asn Ala
Thr Val Pro Asp Gly Glu Cys 355 360 365 Cys Pro Arg Cys Trp Pro Ser
Asp Ser Ala Asp Asp Gly Trp Ser Pro 370 375 380 Trp Ser Glu Trp Thr
Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 385 390 395 400 Gln Arg
Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 405 410 415
Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe
420 425 430 Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser
Cys Ser 435 440 445 Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg
Leu Cys Asn Ser 450 455 460 Pro Ser Pro Gln Met Asn Gly Lys Pro Cys
Glu Gly Glu Ala Arg Glu 465 470 475 480 Thr Lys Ala Cys Lys Lys Asp
Ala Cys Pro Ile Asn Gly Gly Trp Gly 485 490 495 Pro Trp Ser Pro Trp
Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 500 505 510 Gln Lys Arg
Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 515 520 525 Lys
Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 530 535
540 Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val
545 550 555 560 Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly
Ala Cys Pro 565 570 575 Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr
Asp Val Asp Glu Cys 580 585 590 Lys Glu Val Pro Asp Ala Cys Phe Asn
His Asn Gly Glu His Arg Cys 595 600 605 Glu Asn Thr Asp Pro Gly Tyr
Asn Cys Leu Pro Cys Pro Pro Arg Phe 610 615 620 Thr Gly Ser Gln Pro
Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 625 630 635 640 Lys Gln
Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 645 650 655
Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 660
665 670 Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile
Ile 675 680 685 Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu
Asn Leu Val 690 695 700 Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys
Asp Asn Cys Pro Asn 705 710 715 720 Leu Pro Asn Ser Gly Gln Glu Asp
Tyr Asp Lys Asp Gly Ile Gly Asp 725 730 735 Ala Cys Asp Asp Asp Asp
Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 740 745 750 Asn Cys Pro Phe
His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 755 760 765 Asp Val
Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 770 775 780
Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 785
790 795 800 Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln
Tyr Val 805 810 815 Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly
Val Gly Asp Gln 820 825 830 Cys Asp Asn Cys Pro Leu Glu His Asn Pro
Asp Gln Leu Asp Ser Asp 835 840 845 Ser Asp Arg Ile Gly Asp Thr Cys
Asp Asn Asn Gln Asp Ile Asp Glu 850 855 860 Asp Gly His Gln Asn Asn
Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 865 870 875 880 Asn Gln Ala
Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 885 890 895 Asp
Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 900 905
910 Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp
915 920 925 Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile
Asp Asp 930 935 940 Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp
Phe Arg Arg Phe 945 950 955 960 Gln Met Ile Pro Leu Asp Pro Lys Gly
Thr Ser Gln Asn Asp Pro Asn 965 970 975 Trp Val Val Arg His Gln Gly
Lys Glu Leu Val Gln Thr Val Asn Cys 980 985 990 Asp Pro Gly Leu Ala
Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 995 1000 1005 Ser Gly
Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 1010 1015
1020 Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met
Trp 1025 1030 1035 1040 Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn
Pro Thr Arg Ala Gln 1045 1050 1055 Gly Tyr Ser Gly Leu Ser Val Lys
Val Val Asn Ser Thr Thr Gly Pro 1060 1065 1070 Gly Glu His Leu Arg
Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly 1075 1080 1085 Gln Val
Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 1090 1095
1100 Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly
Phe 1105 1110 1115 1120 Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile
Met Ala Asp Ser Gly 1125 1130 1135 Pro Ile Tyr Asp Lys Thr Tyr Ala
Gly Gly Arg Leu Gly Leu Phe Val 1140 1145 1150 Phe Ser Gln Glu Met
Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 1155 1160 1165 Asp Pro
1170 <210> SEQ ID NO 81 <211> LENGTH: 1516 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
81 Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys
1 5 10 15 Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp
Leu Trp 20 25 30 Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr
Ile Pro Glu Pro 35 40 45 Gln Gly Pro Leu Pro Val Gln Pro Thr Ala
Asp Thr Thr Thr His Val 50 55 60 Thr Pro Arg Asn Gly Ser Thr Glu
Pro Ala Thr Ala Pro Gly Ser Pro 65 70 75 80 Glu Pro Pro Ser Glu Leu
Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 85 90 95 Ala Glu Ser Pro
Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 100 105 110 Glu Ile
Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 115 120 125
Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 130
135 140 Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser
Thr 145 150 155 160 Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg
Gly Ile Pro Ser 165 170 175 Ser Pro Gly Ala His Thr Thr Glu Ala Gly
Thr Leu Pro Ala Pro Thr 180 185 190 Pro Ser Pro Pro Ser Leu Gly Arg
Pro Trp Ala Pro Leu Thr Gly Pro 195 200 205 Ser Val Pro Pro Pro Ser
Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 210 215 220 Leu Gln Leu Leu
Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 225 230 235 240 Asp
Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 245 250
255 Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe
260 265 270 Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly
Val Leu 275 280 285 Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu
Leu Gly Val Lys 290 295 300 Leu Ser Gly Val Gln Asp Gly His Gln Asp
Ile Ser Leu Leu Tyr Thr 305 310 315 320 Glu Pro Gly Ala Gly Gln Thr
His Thr Ala Ala Ser Phe Arg Leu Pro 325 330 335 Ala Phe Val Gly Gln
Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 340 345 350 Phe Val Ala
Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 355 360 365 Ala
Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 370 375
380 Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile
385 390 395 400 Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro
Met His Cys 405 410 415 Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala
Ser Gly Asp Ser Gly 420 425 430 Ser Gly Leu Gly Asp Ala Arg Glu Leu
Leu Arg Glu Glu Thr Gly Ala 435 440 445 Ala Leu Lys Pro Arg Leu Pro
Ala Pro Pro Pro Val Thr Thr Pro Pro 450 455 460 Leu Ala Gly Gly Ser
Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 465 470 475 480 Glu Gln
Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 485 490 495
Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 500
505 510 Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val
Pro 515 520 525 Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys
Leu Pro Gly
530 535 540 Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala
Gly Pro 545 550 555 560 Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro
Pro Gly Pro Pro Gly 565 570 575 Arg Asp Gly Thr Pro Gly Arg Asp Gly
Glu Pro Gly Asp Pro Gly Glu 580 585 590 Asp Gly Lys Pro Gly Asp Thr
Gly Pro Gln Gly Phe Pro Gly Thr Pro 595 600 605 Gly Asp Val Gly Pro
Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 610 615 620 Arg Gly Pro
Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 625 630 635 640
Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 645
650 655 Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly
Pro 660 665 670 Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro
Gly Arg Phe 675 680 685 Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala
Gly Leu Pro Gly Val 690 695 700 Pro Gly Arg Glu Gly Pro Pro Gly Phe
Pro Gly Leu Pro Gly Pro Pro 705 710 715 720 Gly Pro Pro Gly Arg Glu
Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 725 730 735 Ser Leu Gly Glu
Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 740 745 750 Pro Gly
Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 755 760 765
Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 770
775 780 Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly
Pro 785 790 795 800 Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln
Gly Pro Pro Gly 805 810 815 Leu Pro Gly Leu Lys Gly Asp Pro Gly Val
Pro Gly Leu Pro Gly Ala 820 825 830 Lys Gly Glu Val Gly Ala Asp Gly
Val Pro Gly Phe Pro Gly Leu Pro 835 840 845 Gly Arg Glu Gly Ile Ala
Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 850 855 860 Ser Arg Gly Glu
Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 865 870 875 880 Gly
Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 885 890
895 Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro
900 905 910 Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn
Leu Gly 915 920 925 Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly
Glu Lys Gly Glu 930 935 940 Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly
Ala Leu Gly Pro Ala Gln 945 950 955 960 Lys Gly Ala Lys Gly Glu Pro
Gly Phe Arg Gly Pro Pro Gly Pro Tyr 965 970 975 Gly Arg Pro Gly Tyr
Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 980 985 990 Arg Pro Gly
Met Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp 995 1000 1005
Ala Ser Leu Gly Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro
1010 1015 1020 Pro Gly Pro Pro Gly Pro Pro Gly Thr Pro Val Tyr Asp
Ser Asn Val 1025 1030 1035 1040 Phe Ala Glu Ser Ser Arg Pro Gly Pro
Pro Gly Leu Pro Gly Asn Gln 1045 1050 1055 Gly Pro Pro Gly Pro Lys
Gly Ala Lys Gly Glu Val Gly Pro Pro Gly 1060 1065 1070 Pro Pro Gly
Gln Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met 1075 1080 1085
Lys Gly Glu Lys Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg
1090 1095 1100 Gly Glu Pro Gly Gly Gly Gly Phe Phe Gly Ser Ser Leu
Pro Gly Pro 1105 1110 1115 1120 Pro Gly Pro Pro Gly Pro Arg Gly Tyr
Pro Gly Ile Pro Gly Pro Lys 1125 1130 1135 Gly Glu Ser Ile Arg Gly
Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro 1140 1145 1150 Pro Gly Ile
Gly Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly 1155 1160 1165
Pro Pro Gly Pro Pro Ser Phe Pro Gly Pro His Arg Gln Thr Ile Ser
1170 1175 1180 Val Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro
Pro Gly Thr 1185 1190 1195 1200 Met Gly Ala Ser Ser Gly Val Arg Leu
Trp Ala Thr Arg Gln Ala Met 1205 1210 1215 Leu Gly Gln Val His Glu
Val Pro Glu Gly Trp Leu Ile Phe Val Ala 1220 1225 1230 Glu Gln Glu
Glu Leu Tyr Val Arg Val Gln Asn Gly Phe Arg Lys Val 1235 1240 1245
Gln Leu Glu Ala Arg Thr Pro Leu Pro Arg Gly Thr Asp Asn Glu Val
1250 1255 1260 Ala Ala Leu Gln Pro Pro Val Val Gln Leu His Asp Ser
Asn Pro Tyr 1265 1270 1275 1280 Pro Arg Arg Glu His Pro His Pro Thr
Ala Arg Pro Trp Arg Ala Asp 1285 1290 1295 Asp Ile Leu Ala Ser Pro
Pro Arg Leu Pro Glu Pro Gln Pro Tyr Pro 1300 1305 1310 Gly Ala Pro
His His Ser Ser Tyr Val His Leu Arg Pro Ala Arg Pro 1315 1320 1325
Thr Ser Pro Pro Ala His Ser His Arg Asp Phe Gln Pro Val Leu His
1330 1335 1340 Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met Arg
Gly Ile Arg 1345 1350 1355 1360 Gly Ala Asp Phe Gln Cys Phe Gln Gln
Ala Arg Ala Val Gly Leu Ala 1365 1370 1375 Gly Thr Phe Arg Ala Phe
Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser 1380 1385 1390 Ile Val Arg
Arg Ala Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys 1395 1400 1405
Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu
1410 1415 1420 Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser Phe Asp
Gly Lys Asp 1425 1430 1435 1440 Val Leu Arg His Pro Thr Trp Pro Gln
Lys Ser Val Trp His Gly Ser 1445 1450 1455 Asp Pro Asn Gly Arg Arg
Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg 1460 1465 1470 Thr Glu Ala
Pro Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly 1475 1480 1485
Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val
1490 1495 1500 Leu Cys Ile Glu Asn Ser Phe Met Thr Ala Ser Lys 1505
1510 1515 <210> SEQ ID NO 82 <211> LENGTH: 1336
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 82 Met Ala Pro Arg Cys Pro Trp Pro Trp Pro
Arg Arg Arg Arg Leu Leu 1 5 10 15 Asp Val Leu Ala Pro Leu Val Leu
Leu Leu Gly Val Arg Ala Ala Ser 20 25 30 Ala Glu Pro Glu Arg Ile
Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 35 40 45 Gly Asp Pro Pro
Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 50 55 60 Gly Leu
Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 65 70 75 80
Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 85
90 95 His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile
Thr 100 105 110 Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu
Ser Gly Val 115 120 125 Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr
Thr Glu Pro Gly Ala 130 135 140 Gly Gln Thr His Thr Ala Ala Ser Phe
Arg Leu Pro Ala Phe Val Gly 145 150 155 160 Gln Trp Thr His Leu Ala
Leu Ser Val Ala Gly Gly Phe Val Ala Leu 165 170 175 Tyr Val Asp Cys
Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 180 185 190 Arg Gly
Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 195 200 205
Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 210
215 220 Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu
Glu 225 230 235 240 Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly
Ser Gly Leu Gly 245 250 255 Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr
Gly Ala Ala Leu Lys Pro 260 265 270 Arg Leu Pro Ala Pro Pro Pro Val
Thr Thr Pro Pro Leu Ala Gly Gly 275 280 285 Ser Ser Thr Glu Asp Ser
Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 290 295 300 Val Ala Ser Leu
Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser
305 310 315 320 Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val
Lys Glu Gly 325 330 335 Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val
Pro Gly Pro Pro Gly 340 345 350 Arg Ala Gly Pro Pro Gly Ser Pro Cys
Leu Pro Gly Pro Pro Gly Leu 355 360 365 Pro Cys Pro Val Ser Pro Leu
Gly Pro Ala Gly Pro Ala Leu Gln Thr 370 375 380 Val Pro Gly Pro Gln
Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr 385 390 395 400 Pro Gly
Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro 405 410 415
Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 420
425 430 Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro
Pro 435 440 445 Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe
Arg His Asp 450 455 460 Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly
Phe Gly Gly Asp Leu 465 470 475 480 Glu Ala Leu Arg Gly Pro Arg Gly
Phe Pro Gly Pro Pro Gly Pro Pro 485 490 495 Gly Val Pro Gly Leu Pro
Gly Glu Pro Gly Arg Phe Gly Val Asn Ser 500 505 510 Ser Asp Val Pro
Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu 515 520 525 Gly Pro
Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 530 535 540
Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 545
550 555 560 Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly
Pro Ala 565 570 575 Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro
Gly Pro Ala Gly 580 585 590 Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro
Pro Gly Pro Gly Leu Pro 595 600 605 Ala Gly Phe Asp Asp Met Glu Gly
Ser Gly Gly Pro Phe Trp Ser Thr 610 615 620 Ala Arg Ser Ala Asp Gly
Pro Gln Gly Pro Pro Gly Leu Pro Gly Leu 625 630 635 640 Lys Gly Asp
Pro Gly Val Pro Gly Leu Pro Gly Ala Lys Gly Glu Val 645 650 655 Gly
Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 660 665
670 Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu
675 680 685 Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu
Pro Gly 690 695 700 Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser
Glu Gln Asp Gly 705 710 715 720 Ser Val Leu Ser Val Pro Gly Pro Glu
Gly Arg Pro Gly Phe Ala Gly 725 730 735 Phe Pro Gly Pro Ala Gly Pro
Lys Gly Asn Leu Gly Ser Lys Gly Glu 740 745 750 Arg Gly Ser Pro Gly
Pro Lys Gly Glu Lys Gly Glu Pro Gly Ser Ile 755 760 765 Phe Ser Pro
Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys Gly Ala Lys 770 775 780 Gly
Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 785 790
795 800 Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly
Met 805 810 815 Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala
Ser Leu Gly 820 825 830 Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly
Pro Pro Gly Pro Pro 835 840 845 Gly Pro Pro Gly Thr Pro Val Tyr Asp
Ser Asn Val Phe Ala Glu Ser 850 855 860 Ser Arg Pro Gly Pro Pro Gly
Leu Pro Gly Asn Gln Gly Pro Pro Gly 865 870 875 880 Pro Lys Gly Ala
Lys Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Gln 885 890 895 Phe Pro
Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys Gly Glu Lys 900 905 910
Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 915
920 925 Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro
Pro 930 935 940 Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly
Glu Ser Ile 945 950 955 960 Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln
Gly Pro Pro Gly Ile Gly 965 970 975 Tyr Glu Gly Arg Gln Gly Pro Pro
Gly Pro Pro Gly Pro Pro Gly Pro 980 985 990 Pro Ser Phe Pro Gly Pro
His Arg Gln Thr Ile Ser Val Pro Gly Pro 995 1000 1005 Pro Gly Pro
Pro Gly Pro Pro Gly Pro Pro Gly Thr Met Gly Ala Ser 1010 1015 1020
Ser Gly Val Arg Leu Trp Ala Thr Arg Gln Ala Met Leu Gly Gln Val
1025 1030 1035 1040 His Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala
Glu Gln Glu Glu 1045 1050 1055 Leu Tyr Val Arg Val Gln Asn Gly Phe
Arg Lys Val Gln Leu Glu Ala 1060 1065 1070 Arg Thr Pro Leu Pro Arg
Gly Thr Asp Asn Glu Val Ala Ala Leu Gln 1075 1080 1085 Pro Pro Val
Val Gln Leu His Asp Ser Asn Pro Tyr Pro Arg Arg Glu 1090 1095 1100
His Pro His Pro Thr Ala Arg Pro Trp Arg Ala Asp Asp Ile Leu Ala
1105 1110 1115 1120 Ser Pro Pro Arg Leu Pro Glu Pro Gln Pro Tyr Pro
Gly Ala Pro His 1125 1130 1135 His Ser Ser Tyr Val His Leu Arg Pro
Ala Arg Pro Thr Ser Pro Pro 1140 1145 1150 Ala His Ser His Arg Asp
Phe Gln Pro Val Leu His Leu Val Ala Leu 1155 1160 1165 Asn Ser Pro
Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe 1170 1175 1180
Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg
1185 1190 1195 1200 Ala Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser
Ile Val Arg Arg 1205 1210 1215 Ala Asp Arg Ala Ala Val Pro Ile Val
Asn Leu Lys Asp Glu Leu Leu 1220 1225 1230 Phe Pro Ser Trp Glu Ala
Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys 1235 1240 1245 Pro Gly Ala
Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 1250 1255 1260
Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly
1265 1270 1275 1280 Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg
Thr Glu Ala Pro 1285 1290 1295 Ser Ala Thr Gly Gln Ala Ser Ser Leu
Leu Gly Gly Arg Leu Leu Gly 1300 1305 1310 Gln Ser Ala Ala Ser Cys
His His Ala Tyr Ile Val Leu Cys Ile Glu 1315 1320 1325 Asn Ser Phe
Met Thr Ala Ser Lys 1330 1335 <210> SEQ ID NO 83 <211>
LENGTH: 1670 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 83 Met Ser Ala Arg Thr Ala Pro Arg
Pro Gln Val Leu Leu Leu Pro Leu 1 5 10 15 Leu Leu Val Leu Leu Ala
Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 20 25 30 Cys Lys Asp Lys
Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 35 40 45 Gly Glu
Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 50 55 60
Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 65
70 75 80 Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly
Ile Ser 85 90 95 Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro
Gly Thr Pro Gly 100 105 110 Asn Thr Gly Pro Tyr Gly Leu Val Gly Val
Pro Gly Cys Ser Gly Ser 115 120 125 Lys Gly Glu Gln Gly Phe Pro Gly
Leu Pro Gly Thr Leu Gly Tyr Pro 130 135 140 Gly Ile Pro Gly Ala Ala
Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 145 150 155 160 Lys Glu Glu
Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 165 170 175 Gly
Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 180 185
190 Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala
195 200 205 Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val
Ile Gly 210 215 220 His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly
Pro Pro Gly Pro 225 230 235 240 Pro Gly Thr Val Ile Val Thr Leu Thr
Gly Pro Asp Asn Arg Thr Asp 245 250 255 Leu Lys Gly Glu Lys Gly Asp
Lys Gly Ala Met Gly Glu Pro Gly Pro
260 265 270 Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu
Lys Gly 275 280 285 Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly
Lys Asp Gly Val 290 295 300 Pro Gly Phe Pro Gly Ser Glu Gly Val Lys
Gly Asn Arg Gly Phe Pro 305 310 315 320 Gly Leu Met Gly Glu Asp Gly
Ile Lys Gly Gln Lys Gly Asp Ile Gly 325 330 335 Pro Pro Gly Phe Arg
Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 340 345 350 Lys Gly Asp
Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 355 360 365 Gly
Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 370 375
380 Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys
385 390 395 400 Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala
Met Gly Thr 405 410 415 Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly
Leu Pro Gly Ser Pro 420 425 430 Gly Pro Pro Gly Pro Pro Gly Asp Ile
Val Phe Arg Lys Gly Pro Pro 435 440 445 Gly Asp His Gly Leu Pro Gly
Tyr Leu Gly Ser Pro Gly Ile Pro Gly 450 455 460 Val Asp Gly Pro Lys
Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 465 470 475 480 Tyr Ile
Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 485 490 495
Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 500
505 510 Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe
Pro 515 520 525 Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly
Glu Thr Leu 530 535 540 Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp
Pro Gly Leu Arg Gly 545 550 555 560 Gln Pro Gly Arg Lys Gly Leu Asp
Gly Ile Pro Gly Thr Pro Gly Val 565 570 575 Lys Gly Leu Pro Gly Pro
Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 580 585 590 Gly Asp Gln Gly
Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 595 600 605 Pro Ala
Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 610 615 620
Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 625
630 635 640 Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val
Pro Gly 645 650 655 Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly
Pro Gln Gly Pro 660 665 670 Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys
Gly Asp Pro Gly Leu Pro 675 680 685 Gly Pro Asp Gly Glu Pro Gly Ile
Pro Gly Ile Gly Phe Pro Gly Pro 690 695 700 Pro Gly Pro Lys Gly Asp
Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 705 710 715 720 Gly Cys Pro
Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 725 730 735 Leu
Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 740 745
750 Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly
755 760 765 Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro
Gly Asn 770 775 780 Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln
Pro Gly Pro Pro 785 790 795 800 Gly Glu Gln Gly Pro Pro Gly Arg Cys
Ile Glu Gly Pro Arg Gly Ala 805 810 815 Gln Gly Leu Pro Gly Leu Asn
Gly Leu Lys Gly Gln Gln Gly Arg Arg 820 825 830 Gly Lys Thr Gly Pro
Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 835 840 845 Ser Gly Phe
Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 850 855 860 Gly
Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 865 870
875 880 Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly
Phe 885 890 895 Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro
Gly Thr Pro 900 905 910 Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val
Lys Gly Gln Arg Gly 915 920 925 Thr Pro Gly Ala Lys Gly Glu Gln Gly
Asp Lys Gly Asn Pro Gly Pro 930 935 940 Ser Glu Ile Ser His Val Ile
Gly Asp Lys Gly Glu Pro Gly Leu Lys 945 950 955 960 Gly Phe Ala Gly
Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 965 970 975 Met Pro
Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 980 985 990
Pro Gly Pro Arg Gly Asp Leu Gly Ser Thr Gly Asn Pro Gly Glu Pro 995
1000 1005 Gly Leu Arg Gly Ile Pro Gly Ser Met Gly Asn Met Gly Met
Pro Gly 1010 1015 1020 Ser Lys Gly Lys Arg Gly Thr Leu Gly Phe Pro
Gly Arg Ala Gly Arg 1025 1030 1035 1040 Pro Gly Leu Pro Gly Ile His
Gly Leu Gln Gly Asp Lys Gly Glu Pro 1045 1050 1055 Gly Tyr Ser Glu
Gly Thr Arg Pro Gly Pro Pro Gly Pro Thr Gly Asp 1060 1065 1070 Pro
Gly Leu Pro Gly Asp Met Gly Lys Lys Gly Glu Met Gly Gln Pro 1075
1080 1085 Gly Pro Pro Gly His Leu Gly Pro Ala Gly Pro Glu Gly Ala
Pro Gly 1090 1095 1100 Ser Pro Gly Ser Pro Gly Leu Pro Gly Lys Pro
Gly Pro His Gly Asp 1105 1110 1115 1120 Leu Gly Phe Lys Gly Ile Lys
Gly Leu Leu Gly Pro Pro Gly Ile Arg 1125 1130 1135 Gly Pro Pro Gly
Leu Pro Gly Phe Pro Gly Ser Pro Gly Pro Met Gly 1140 1145 1150 Ile
Arg Gly Asp Gln Gly Arg Asp Gly Ile Pro Gly Pro Ala Gly Glu 1155
1160 1165 Lys Gly Glu Thr Gly Leu Leu Arg Ala Pro Pro Gly Pro Arg
Gly Asn 1170 1175 1180 Pro Gly Ala Gln Gly Ala Lys Gly Asp Arg Gly
Ala Pro Gly Phe Pro 1185 1190 1195 1200 Gly Leu Pro Gly Arg Lys Gly
Ala Met Gly Asp Ala Gly Pro Arg Gly 1205 1210 1215 Pro Thr Gly Ile
Glu Gly Phe Pro Gly Pro Pro Gly Leu Pro Gly Ala 1220 1225 1230 Ile
Ile Pro Gly Gln Thr Gly Asn Arg Gly Pro Pro Gly Ser Arg Gly 1235
1240 1245 Ser Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Gly Ser His
Val Ile 1250 1255 1260 Gly Ile Lys Gly Asp Lys Gly Ser Met Gly His
Pro Gly Pro Lys Gly 1265 1270 1275 1280 Pro Pro Gly Thr Ala Gly Asp
Met Gly Pro Pro Gly Arg Leu Gly Ala 1285 1290 1295 Pro Gly Thr Pro
Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Phe Gln 1300 1305 1310 Gly
Phe Pro Gly Val Lys Gly Glu Lys Gly Asn Pro Gly Phe Leu Gly 1315
1320 1325 Ser Ile Gly Pro Pro Gly Pro Ile Gly Pro Lys Gly Pro Pro
Gly Val 1330 1335 1340 Arg Gly Asp Pro Gly Thr Leu Lys Ile Ile Ser
Leu Pro Gly Ser Pro 1345 1350 1355 1360 Gly Pro Pro Gly Thr Pro Gly
Glu Pro Gly Met Gln Gly Glu Pro Gly 1365 1370 1375 Pro Pro Gly Pro
Pro Gly Asn Leu Gly Pro Cys Gly Pro Arg Gly Lys 1380 1385 1390 Pro
Gly Lys Asp Gly Lys Pro Gly Thr Pro Gly Pro Ala Gly Glu Lys 1395
1400 1405 Gly Asn Lys Gly Ser Lys Gly Glu Pro Gly Pro Ala Gly Ser
Asp Gly 1410 1415 1420 Leu Pro Gly Leu Lys Gly Lys Arg Gly Asp Ser
Gly Ser Pro Ala Thr 1425 1430 1435 1440 Trp Thr Thr Arg Gly Phe Val
Phe Thr Arg His Ser Gln Thr Thr Ala 1445 1450 1455 Ile Pro Ser Cys
Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser 1460 1465 1470 Phe
Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly 1475
1480 1485 Thr Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe
Leu Phe 1490 1495 1500 Cys Asn Val Asn Asp Val Cys Asn Phe Ala Ser
Arg Asn Asp Tyr Ser 1505 1510 1515 1520 Tyr Trp Leu Ser Thr Pro Ala
Leu Met Pro Met Asn Met Ala Pro Ile 1525 1530 1535 Thr Gly Arg Ala
Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu 1540 1545 1550 Gly
Pro Ala Ile Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro 1555
1560 1565 Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser
Phe Ile 1570 1575 1580 Met Phe Thr Ser Ala Gly Ser Glu Gly Thr Gly
Gln Ala Leu Ala Ser 1585 1590 1595 1600
Pro Gly Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys
1605 1610 1615 His Gly Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr
Ser Phe Trp 1620 1625 1630 Leu Ala Ser Leu Asn Pro Glu Arg Met Phe
Arg Lys Pro Ile Pro Ser 1635 1640 1645 Thr Val Lys Ala Gly Glu Leu
Glu Lys Ile Ile Ser Arg Cys Gln Val 1650 1655 1660 Cys Met Lys Lys
Arg His 1665 1670 <210> SEQ ID NO 84 <211> LENGTH: 1712
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 84 Met Gly Arg Asp Gln Arg Ala Val Ala Gly
Pro Ala Leu Arg Arg Trp 1 5 10 15 Leu Leu Leu Gly Thr Val Thr Val
Gly Phe Leu Ala Gln Ser Val Leu 20 25 30 Ala Gly Val Lys Lys Phe
Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 35 40 45 Gly Gly Cys Gln
Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 50 55 60 Pro Val
Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 65 70 75 80
Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 85
90 95 Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser
Gly 100 105 110 Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln
Gly Gly Pro 115 120 125 Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly
Thr Gln Gly Asp Ser 130 135 140 Gly Pro Gln Gly Pro Pro Gly Ser Glu
Gly Phe Thr Gly Pro Pro Gly 145 150 155 160 Pro Gln Gly Pro Lys Gly
Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 165 170 175 Glu Glu Arg Asp
Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 180 185 190 Gly Phe
Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 195 200 205
Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 210
215 220 Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys
Gly 225 230 235 240 Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly
Ile Pro Ser Asp 245 250 255 Thr Leu His Pro Ile Ile Ala Pro Thr Gly
Val Thr Phe His Pro Asp 260 265 270 Gln Tyr Lys Gly Glu Lys Gly Ser
Glu Gly Glu Pro Gly Ile Arg Gly 275 280 285 Ile Ser Leu Lys Gly Glu
Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 290 295 300 Gly Tyr Pro Gly
Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 305 310 315 320 Ser
Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 325 330
335 Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser
340 345 350 Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly
Phe Pro 355 360 365 Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro
Gly Asp Pro Gly 370 375 380 Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly
Asp Gly Asp Gln Arg Arg 385 390 395 400 Gly Leu Pro Gly Glu Met Gly
Pro Lys Gly Phe Ile Gly Asp Pro Gly 405 410 415 Ile Pro Ala Leu Tyr
Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 420 425 430 Pro Pro Gly
Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 435 440 445 Leu
Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 450 455
460 Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala
465 470 475 480 Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys
Gly Leu Pro 485 490 495 Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile
Asn Gly Glu Pro Gly 500 505 510 Arg Lys Gly Asp Arg Gly Asp Pro Gly
Gln His Gly Leu Pro Gly Phe 515 520 525 Pro Gly Leu Lys Gly Val Pro
Gly Asn Ile Gly Ala Pro Gly Pro Lys 530 535 540 Gly Ala Lys Gly Asp
Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 545 550 555 560 Gln Pro
Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 565 570 575
Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 580
585 590 Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly
Ile 595 600 605 Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro
Gly Leu Gly 610 615 620 Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro
Gly Asp Ala Gly Leu 625 630 635 640 Pro Gly Pro Pro Gly Phe Leu Gly
Pro Pro Gly Pro Ala Gly Thr Pro 645 650 655 Gly Gln Ile Asp Cys Asp
Thr Asp Val Lys Arg Ala Val Gly Gly Asp 660 665 670 Arg Gln Glu Ala
Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 675 680 685 Pro Gly
Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 690 695 700
Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 705
710 715 720 Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro
Gly Phe 725 730 735 Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu
Pro Gly Pro Asp 740 745 750 Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly
Pro Asp Gly Pro Pro Gly 755 760 765 Glu Arg Gly Leu Pro Gly Glu Val
Leu Gly Ala Gln Pro Gly Pro Arg 770 775 780 Gly Asp Ala Gly Val Pro
Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 785 790 795 800 Asp Arg Gly
Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 805 810 815 Pro
Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 820 825
830 Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly
835 840 845 Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu
Gly Leu 850 855 860 Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala
Pro Gly Pro Val 865 870 875 880 Gly Met Lys Gly Leu Ser Gly Asp Arg
Gly Asp Ala Gly Phe Thr Gly 885 890 895 Glu Gln Gly His Pro Gly Ser
Pro Gly Phe Lys Gly Ile Asp Gly Met 900 905 910 Pro Gly Thr Pro Gly
Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 915 920 925 Gly Phe Gln
Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 930 935 940 Ser
Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 945 950
955 960 Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro
Pro 965 970 975 Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile
Lys Gly Glu 980 985 990 Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly
Tyr Leu Gly Ala Lys 995 1000 1005 Gly Ile Gln Gly Met Pro Gly Ile
Pro Gly Leu Ser Gly Ile Pro Gly 1010 1015 1020 Leu Pro Gly Arg Pro
Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly 1025 1030 1035 1040 Val
Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro 1045
1050 1055 Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly
Asp Lys 1060 1065 1070 Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu
Ile Gly Ala Thr Gly 1075 1080 1085 Asp Phe Gly Asp Ile Gly Asp Thr
Ile Asn Leu Pro Gly Arg Pro Gly 1090 1095 1100 Leu Lys Gly Glu Arg
Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe 1105 1110 1115 1120 Phe
Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr 1125
1130 1135 Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln
Thr Gly 1140 1145 1150 Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln
Gly Glu Leu Gly Arg 1155 1160 1165 Ile Gly Leu Pro Gly Gly Lys Gly
Asp Asp Gly Trp Pro Gly Ala Pro 1170 1175 1180 Gly Leu Pro Gly Phe
Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly 1185 1190 1195 1200 Leu
Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His 1205
1210 1215
Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly
1220 1225 1230 Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly
Gln Lys Gly 1235 1240 1245 Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro
Pro Gly Ser Pro Gly Leu 1250 1255 1260 Gln Gly Phe Pro Gly Ile Thr
Pro Pro Ser Asn Ile Ser Gly Ala Pro 1265 1270 1275 1280 Gly Asp Lys
Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly 1285 1290 1295
Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly Asp
1300 1305 1310 Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys
Gly Trp Ala 1315 1320 1325 Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly
Val Phe Gly Leu Pro Gly 1330 1335 1340 Glu Lys Gly Pro Arg Gly Glu
Gln Gly Phe Met Gly Asn Thr Gly Pro 1345 1350 1355 1360 Thr Gly Ala
Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro 1365 1370 1375
Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala Gly
1380 1385 1390 Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly
Pro Gln Gly 1395 1400 1405 Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu
Met Gly Pro Gln Gly Pro 1410 1415 1420 Pro Gly Glu Pro Gly Phe Arg
Gly Ala Pro Gly Lys Ala Gly Pro Gln 1425 1430 1435 1440 Gly Arg Gly
Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly 1445 1450 1455
Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg
1460 1465 1470 Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser
Val Ser Ile 1475 1480 1485 Gly Tyr Leu Leu Val Lys His Ser Gln Thr
Asp Gln Glu Pro Met Cys 1490 1495 1500 Pro Val Gly Met Asn Lys Leu
Trp Ser Gly Tyr Ser Leu Leu Tyr Phe 1505 1510 1515 1520 Glu Gly Gln
Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser 1525 1530 1535
Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly
1540 1545 1550 Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr
Trp Leu Ser 1555 1560 1565 Thr Thr Ala Pro Leu Pro Met Met Pro Val
Ala Glu Asp Glu Ile Lys 1570 1575 1580 Pro Tyr Ile Ser Arg Cys Ser
Val Cys Glu Ala Pro Ala Ile Ala Ile 1585 1590 1595 1600 Ala Val His
Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp 1605 1610 1615
Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly
1620 1625 1630 Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser
Cys Leu Glu 1635 1640 1645 Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys
Asn Gly Gly Arg Gly Thr 1650 1655 1660 Cys His Tyr Tyr Ala Asn Lys
Tyr Ser Phe Trp Leu Thr Thr Ile Pro 1665 1670 1675 1680 Glu Gln Ser
Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly 1685 1690 1695
Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu
1700 1705 1710 <210> SEQ ID NO 85 <211> LENGTH: 1427
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 85 Met Ser Met Leu Lys Pro Ser Gly Leu Lys
Ala Pro Thr Lys Ile Leu 1 5 10 15 Lys Pro Gly Ser Thr Ala Leu Lys
Thr Pro Thr Ala Val Val Ala Pro 20 25 30 Val Glu Lys Thr Ile Ser
Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 35 40 45 Glu Thr Gln Glu
Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 50 55 60 Trp Val
Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 65 70 75 80
Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 85
90 95 Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys
Glu 100 105 110 Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr
Arg Lys Val 115 120 125 Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr
Thr Pro Ala Ser Arg 130 135 140 Ala Thr Ser Pro Leu Cys Thr Ser Thr
Ala Ser Met Val Ser Ser Ser 145 150 155 160 Pro Ser Thr Pro Ser Asn
Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 165 170 175 Lys Glu Pro Ser
Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 180 185 190 Ser Glu
Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 195 200 205
Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 210
215 220 Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly
Glu 225 230 235 240 Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys
Asn Asp Gly Ala 245 250 255 Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln
Pro Lys Tyr Gly Leu Phe 260 265 270 Ala Pro Val His Lys Val Thr Lys
Ile Gly Phe Pro Ser Thr Thr Pro 275 280 285 Ala Lys Ala Lys Ala Asn
Ala Val Arg Arg Val Met Ala Thr Thr Ser 290 295 300 Ala Ser Leu Lys
Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 305 310 315 320 Ser
Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 325 330
335 Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala
340 345 350 Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln
Leu Leu 355 360 365 Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys
Ala Thr Ser His 370 375 380 Val Gly Glu Ile Glu Gln Glu Leu Ala Leu
Ala Arg Asp Gly His Asp 385 390 395 400 Gln His Val Leu Glu Leu Glu
Ala Lys Met Asp Gln Leu Arg Thr Met 405 410 415 Val Glu Ala Ala Asp
Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 420 425 430 Glu Glu Lys
Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 435 440 445 Ser
Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Lys Leu Glu His Ala 450 455
460 Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala
465 470 475 480 Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg Val Ala
Thr Val Ser 485 490 495 Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp
Leu Ala Leu Arg Val 500 505 510 Gln Glu Val Ala Glu Leu Arg Arg Arg
Leu Glu Ser Asn Lys Pro Ala 515 520 525 Gly Asp Val Asp Met Ser Leu
Ser Leu Leu Gln Glu Ile Ser Ser Leu 530 535 540 Gln Glu Lys Leu Glu
Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr 545 550 555 560 Ser Leu
Lys Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu 565 570 575
Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu 580
585 590 Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp
Val 595 600 605 Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala
Ser His Gln 610 615 620 Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser
Lys Gly Leu Gly Thr 625 630 635 640 Glu Thr Ala Glu Phe Ala Glu Leu
Lys Thr Gln Ile Glu Lys Met Arg 645 650 655 Leu Asp Tyr Gln His Glu
Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser 660 665 670 Glu Arg Ala Ala
His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu 675 680 685 Met Lys
Val Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser 690 695 700
Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr 705
710 715 720 Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu
Glu Val 725 730 735 Leu Gln Ala Lys Cys Asn Glu Gln Thr Lys Val Ile
Asp Asn Phe Thr 740 745 750 Ser Gln Leu Lys Ala Thr Glu Glu Lys Leu
Leu Asp Leu Asp Ala Leu 755 760 765 Arg Lys Ala Ser Ser Glu Gly Lys
Ser Glu Met Lys Lys Leu Arg Gln 770 775 780 Gln Leu Glu Ala Ala Glu
Lys Gln Ile Lys His Leu Glu Ile Glu Lys 785 790 795 800
Asn Ala Glu Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly 805
810 815 Arg Glu Leu Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val
Ser 820 825 830 Gln Val Lys Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu
Lys Glu Lys 835 840 845 Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val
Gln Arg Ser Met Gln 850 855 860 Glu Thr Val Asn Lys Leu His Gln Lys
Glu Glu Gln Phe Asn Met Leu 865 870 875 880 Ser Ser Asp Leu Glu Lys
Leu Arg Glu Asn Leu Ala Asp Met Glu Ala 885 890 895 Lys Phe Arg Glu
Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys 900 905 910 Glu Lys
Leu Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp 915 920 925
Asn Ser Ser Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu 930
935 940 Arg Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu
Asn 945 950 955 960 Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr
Val Lys Ala Glu 965 970 975 Gln Ser Gln Gln Glu Ala Ala Lys Lys His
Glu Glu Glu Lys Lys Glu 980 985 990 Leu Glu Arg Lys Leu Ser Asp Leu
Glu Lys Lys Met Glu Thr Ser His 995 1000 1005 Asn Gln Cys Gln Glu
Leu Lys Ala Arg Tyr Glu Arg Ala Thr Ser Glu 1010 1015 1020 Thr Lys
Thr Lys His Glu Glu Ile Leu Gln Asn Leu Gln Lys Thr Leu 1025 1030
1035 1040 Leu Asp Thr Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn
Ser Gly 1045 1050 1055 Leu Leu Gln Glu Leu Glu Glu Leu Arg Lys Gln
Ala Asp Lys Ala Lys 1060 1065 1070 Ala Ala Gln Thr Ala Glu Asp Ala
Met Gln Ile Met Glu Gln Met Thr 1075 1080 1085 Lys Glu Lys Thr Glu
Thr Leu Ala Ser Leu Glu Asp Thr Lys Gln Thr 1090 1095 1100 Asn Ala
Lys Leu Gln Asn Glu Leu Asp Thr Leu Lys Glu Asn Asn Leu 1105 1110
1115 1120 Lys Asn Val Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr
Val Glu 1125 1130 1135 Asn Gln Lys Met Glu Glu Phe Arg Lys Glu Ile
Glu Thr Leu Lys Gln 1140 1145 1150 Ala Ala Ala Gln Lys Ser Gln Gln
Leu Ser Ala Leu Gln Glu Glu Asn 1155 1160 1165 Val Lys Leu Ala Glu
Glu Leu Gly Arg Ser Arg Asp Glu Val Thr Ser 1170 1175 1180 His Gln
Lys Leu Glu Glu Glu Arg Ser Val Leu Asn Asn Gln Leu Leu 1185 1190
1195 1200 Glu Met Lys Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp
Glu Glu 1205 1210 1215 Lys Ala Ser Leu Gln Lys Ser Ile Ser Ile Thr
Ser Ala Leu Leu Thr 1220 1225 1230 Glu Lys Asp Ala Glu Leu Glu Lys
Leu Arg Asn Glu Val Thr Val Leu 1235 1240 1245 Arg Gly Glu Asn Ala
Ser Ala Lys Ser Leu His Ser Val Val Gln Thr 1250 1255 1260 Leu Glu
Ser Asp Lys Val Lys Leu Glu Leu Lys Val Lys Asn Leu Glu 1265 1270
1275 1280 Leu Gln Leu Lys Glu Asn Lys Arg Gln Leu Ser Ser Ser Ser
Gly Asn 1285 1290 1295 Thr Asp Thr Gln Ala Asp Glu Asp Glu Arg Ala
Gln Glu Ser Gln Ile 1300 1305 1310 Asp Phe Leu Asn Ser Val Ile Val
Asp Leu Gln Arg Lys Asn Gln Asp 1315 1320 1325 Leu Lys Met Lys Val
Glu Met Met Ser Glu Ala Ala Leu Asn Gly Asn 1330 1335 1340 Gly Asp
Asp Leu Asn Asn Tyr Asp Ser Asp Asp Gln Glu Lys Gln Ser 1345 1350
1355 1360 Lys Lys Lys Pro Arg Leu Phe Cys Asp Ile Cys Asp Cys Phe
Asp Leu 1365 1370 1375 His Asp Thr Glu Asp Cys Pro Thr Gln Ala Gln
Met Ser Glu Asp Pro 1380 1385 1390 Pro His Ser Thr His His Gly Ser
Arg Gly Glu Glu Arg Pro Tyr Cys 1395 1400 1405 Glu Ile Cys Glu Met
Phe Gly His Trp Ala Thr Asn Cys Asn Asp Asp 1410 1415 1420 Glu Thr
Phe 1425 <210> SEQ ID NO 86 <211> LENGTH: 251
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 86 Met Ala Glu Asp Leu Gly Leu Ser Phe Gly
Glu Thr Ala Ser Val Glu 1 5 10 15 Met Leu Pro Glu His Gly Ser Cys
Arg Pro Lys Ala Arg Ser Ser Ser 20 25 30 Ala Arg Trp Ala Leu Thr
Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 35 40 45 Gly Leu Thr Thr
Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 50 55 60 Ala Cys
Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 65 70 75 80
His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 85
90 95 Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys
Asn 100 105 110 Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu
Ala Phe Thr 115 120 125 Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu
Leu Ile Pro Glu Ser 130 135 140 Gly Asp Tyr Phe Ile Tyr Ser Gln Val
Thr Phe Arg Gly Met Thr Ser 145 150 155 160 Glu Cys Ser Glu Ile Arg
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 165 170 175 Ile Thr Val Val
Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 180 185 190 Gln Leu
Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 195 200 205
Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 210
215 220 Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr
Lys 225 230 235 240 Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 245
250 <210> SEQ ID NO 87 <211> LENGTH: 498 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
87 Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His
1 5 10 15 Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly
Arg Arg 20 25 30 Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr
Phe Ile Leu Pro 35 40 45 Glu His Asp Gly Asn Cys Arg Glu Ser Thr
Thr Asp Gln Tyr Asn Thr 50 55 60 Asn Ala Leu Gln Arg Asp Ala Pro
His Val Glu Pro Asp Phe Ser Ser 65 70 75 80 Gln Lys Leu Gln His Leu
Glu His Val Met Glu Asn Tyr Thr Gln Trp 85 90 95 Leu Gln Lys Leu
Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 100 105 110 Ala Gln
Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 115 120 125
Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 130
135 140 Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu
Glu 145 150 155 160 Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys
Leu Glu Lys Gln 165 170 175 Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys
Ile His Glu Lys Asn Ser 180 185 190 Leu Leu Glu His Lys Ile Leu Glu
Met Glu Gly Lys His Lys Glu Glu 195 200 205 Leu Asp Thr Leu Lys Glu
Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 210 215 220 Arg Gln Thr Tyr
Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 225 230 235 240 Thr
Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 245 250
255 Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu
260 265 270 Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys
Ala Asp 275 280 285 Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr
Thr Ile Tyr Ile 290 295 300 Asn Asn Met Pro Glu Pro Lys Lys Val Phe
Cys Asn Met Asp Val Asn 305 310 315 320 Gly Gly Gly Trp Thr Val Ile
Gln His Arg Glu Asp Gly Ser Leu Asp 325 330 335 Phe Gln Arg Gly Trp
Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser 340 345 350 Gly Glu Tyr
Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln
355 360 365 Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly
Asn Arg 370 375 380 Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn
Glu Lys Gln Asn 385 390 395 400 Tyr Arg Leu Tyr Leu Lys Gly His Thr
Gly Thr Ala Gly Lys Gln Ser 405 410 415 Ser Leu Ile Leu His Gly Ala
Asp Phe Ser Thr Lys Asp Ala Asp Asn 420 425 430 Asp Asn Cys Met Cys
Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp 435 440 445 Phe Asp Ala
Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala 450 455 460 Gly
Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys 465 470
475 480 Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro
Leu 485 490 495 Asp Phe <210> SEQ ID NO 88 <211 >
LENGTH: 227 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 88 Met Asn Ile Lys Gly Ser Pro Trp
Lys Gly Ser Leu Leu Leu Leu Leu 1 5 10 15 Val Ser Asn Leu Leu Leu
Cys Gln Ser Val Ala Pro Leu Pro Ile Cys 20 25 30 Pro Gly Gly Ala
Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 35 40 45 Arg Ala
Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 50 55 60
Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 65
70 75 80 Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro
Glu Asp 85 90 95 Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe
Leu Ser Leu Ile 100 105 110 Val Ser Ile Leu Arg Ser Trp Asn Glu Pro
Leu Tyr His Leu Val Thr 115 120 125 Glu Val Arg Gly Met Gln Glu Ala
Pro Glu Ala Ile Leu Ser Lys Ala 130 135 140 Val Glu Ile Glu Glu Gln
Thr Lys Arg Leu Leu Glu Gly Met Glu Leu 145 150 155 160 Ile Val Ser
Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 165 170 175 Val
Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 180 185
190 Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His
195 200 205 Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile
His Asn 210 215 220 Asn Asn Cys 225 <210> SEQ ID NO 89
<211> LENGTH: 4391 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 89 Met Gly Trp Arg Ala
Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 1 5 10 15 Gly Arg Leu
Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 20 25 30 Ser
Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 35 40
45 Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile
50 55 60 Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp
Phe Gln 65 70 75 80 Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg
Ser Ile Glu Tyr 85 90 95 Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg
Glu Phe Arg Glu Val Ser 100 105 110 Glu Ala Val Val Asp Thr Leu Glu
Ser Glu Tyr Leu Lys Ile Pro Gly 115 120 125 Asp Gln Val Val Ser Val
Val Phe Ile Lys Glu Leu Asp Gly Trp Val 130 135 140 Phe Val Glu Leu
Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 145 150 155 160 Ile
Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 165 170
175 Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val
180 185 190 Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys
His Ser 195 200 205 Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp
Arg Arg Pro Asp 210 215 220 Cys Arg Asp Met Ser Asp Glu Leu Asn Cys
Glu Glu Pro Val Leu Gly 225 230 235 240 Ile Ser Pro Thr Phe Ser Leu
Leu Val Glu Thr Thr Ser Leu Pro Pro 245 250 255 Arg Pro Glu Thr Thr
Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 260 265 270 Gln Pro Leu
Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 275 280 285 Glu
Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 290 295
300 Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly
305 310 315 320 Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly
Asn Gly His 325 330 335 Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp
Phe Asp Cys Glu Asp 340 345 350 Arg Thr Asp Glu Ala Asn Cys Pro Thr
Lys Arg Pro Glu Glu Val Cys 355 360 365 Gly Pro Thr Gln Phe Arg Cys
Val Ser Thr Asn Met Cys Ile Pro Ala 370 375 380 Ser Phe His Cys Asp
Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 385 390 395 400 Phe Gly
Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 405 410 415
Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 420
425 430 Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile
Pro 435 440 445 Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg
Gly Thr Leu 450 455 460 Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly
Ala Tyr Thr Cys Glu 465 470 475 480 Ala Met Asn Ala Arg Gly Met Val
Phe Gly Ile Pro Asp Gly Val Leu 485 490 495 Glu Leu Val Pro Gln Arg
Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 500 505 510 Glu His Ser Ala
Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 515 520 525 Val Cys
Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 530 535 540
Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 545
550 555 560 Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp
Pro Ser 565 570 575 Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg
Phe Leu Val His 580 585 590 Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe
Leu Gly Asn Lys Val Asp 595 600 605 Ser Tyr Gly Gly Ser Leu Arg Tyr
Asn Val Arg Tyr Glu Leu Ala Arg 610 615 620 Gly Met Leu Glu Pro Val
Gln Arg Pro Asp Val Val Leu Met Gly Ala 625 630 635 640 Gly Tyr Arg
Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 645 650 655 Leu
Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 660 665
670 Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser
675 680 685 Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met
Ala Ser 690 695 700 Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val
Thr His Ala Thr 705 710 715 720 Ser His Gly Arg Ala His Ser Val Glu
Glu Cys Arg Cys Pro Ile Gly 725 730 735 Tyr Ser Gly Leu Ser Cys Glu
Ser Cys Asp Ala His Phe Thr Arg Val 740 745 750 Pro Gly Gly Pro Tyr
Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 755 760 765 His Ala Ser
Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 770 775 780 His
Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 785 790
795 800 Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro
Cys 805 810 815 Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys
Phe Leu Asp 820 825 830 Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala
Pro Gly Tyr Thr Gly 835 840 845 Arg Arg Cys Glu Ser Cys Ala Pro Gly
Tyr Glu Gly Asn Pro Ile Gln 850 855 860 Pro Gly Gly Lys Cys Arg Pro
Val Asn Gln Glu Ile Val Arg Cys Asp 865 870 875 880
Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 885
890 895 Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe
His 900 905 910 Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe
Cys Met Gly 915 920 925 Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser
Arg Ala Gln Leu His 930 935 940 Gly Ala Ser Glu Glu Pro Gly His Phe
Ser Leu Thr Asn Ala Ala Ser 945 950 955 960 Thr His Thr Thr Asn Glu
Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 965 970 975 Gly Phe Ser Ser
Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 980 985 990 Leu Pro
Ser Arg Phe Leu Gly Asp Lys Val Thr Ser Tyr Gly Gly Glu 995 1000
1005 Leu Arg Phe Thr Val Thr Gln Arg Ser Gln Pro Gly Ser Thr Pro
Leu 1010 1015 1020 His Gly Gln Pro Leu Val Val Leu Gln Gly Asn Asn
Ile Ile Leu Glu 1025 1030 1035 1040 His His Val Ala Gln Glu Pro Ser
Pro Gly Gln Pro Ser Thr Phe Ile 1045 1050 1055 Val Pro Phe Arg Glu
Gln Ala Trp Gln Arg Pro Asp Gly Gln Pro Ala 1060 1065 1070 Thr Arg
Glu His Leu Leu Met Ala Leu Ala Gly Ile Asp Thr Leu Leu 1075 1080
1085 Ile Arg Ala Ser Tyr Ala Gln Gln Pro Ala Glu Ser Arg Val Ser
Gly 1090 1095 1100 Ile Ser Met Asp Val Ala Val Pro Glu Glu Thr Gly
Gln Asp Pro Ala 1105 1110 1115 1120 Leu Glu Val Glu Gln Cys Ser Cys
Pro Pro Gly Tyr Arg Gly Pro Ser 1125 1130 1135 Cys Gln Asp Cys Asp
Thr Gly Tyr Thr Arg Thr Pro Ser Gly Leu Tyr 1140 1145 1150 Leu Gly
Thr Cys Glu Arg Cys Ser Cys His Gly His Ser Glu Ala Cys 1155 1160
1165 Glu Pro Glu Thr Gly Ala Cys Gln Gly Cys Gln His His Thr Glu
Gly 1170 1175 1180 Pro Arg Cys Glu Gln Cys Gln Pro Gly Tyr Tyr Gly
Asp Ala Gln Arg 1185 1190 1195 1200 Gly Thr Pro Gln Asp Cys Gln Leu
Cys Pro Cys Tyr Gly Asp Pro Ala 1205 1210 1215 Ala Gly Gln Ala Ala
His Thr Cys Phe Leu Asp Thr Asp Gly His Pro 1220 1225 1230 Thr Cys
Asp Ala Cys Ser Pro Gly His Ser Gly Arg His Cys Glu Arg 1235 1240
1245 Cys Ala Pro Gly Tyr Tyr Gly Asn Pro Ser Gln Gly Gln Pro Cys
Gln 1250 1255 1260 Arg Asp Ser Gln Val Pro Gly Pro Ile Gly Cys Asn
Cys Asp Pro Gln 1265 1270 1275 1280 Gly Ser Val Ser Ser Gln Cys Asp
Ala Ala Gly Gln Cys Gln Cys Lys 1285 1290 1295 Ala Gln Val Glu Gly
Leu Thr Cys Ser His Cys Arg Pro His His Phe 1300 1305 1310 His Leu
Ser Ala Ser Asn Pro Asp Gly Cys Leu Pro Cys Phe Cys Met 1315 1320
1325 Gly Ile Thr Gln Gln Cys Ala Ser Ser Ala Tyr Thr Arg His Leu
Ile 1330 1335 1340 Ser Thr His Phe Ala Pro Gly Asp Phe Gln Gly Phe
Ala Leu Val Asn 1345 1350 1355 1360 Pro Gln Arg Asn Ser Arg Leu Thr
Gly Glu Phe Thr Val Glu Pro Val 1365 1370 1375 Pro Glu Gly Ala Gln
Leu Ser Phe Gly Asn Phe Ala Gln Leu Gly His 1380 1385 1390 Glu Ser
Phe Tyr Trp Gln Leu Pro Glu Thr Tyr Gln Gly Asp Lys Val 1395 1400
1405 Ala Ala Tyr Gly Gly Lys Leu Arg Tyr Thr Leu Ser Tyr Thr Ala
Gly 1410 1415 1420 Pro Gln Gly Ser Pro Leu Ser Asp Pro Asp Val Gln
Ile Thr Gly Asn 1425 1430 1435 1440 Asn Ile Met Leu Val Ala Ser Gln
Pro Ala Leu Gln Gly Pro Glu Arg 1445 1450 1455 Arg Ser Tyr Glu Ile
Met Phe Arg Glu Glu Phe Trp Arg Arg Pro Asp 1460 1465 1470 Gly Gln
Pro Ala Thr Arg Glu His Leu Leu Met Ala Leu Ala Asp Leu 1475 1480
1485 Asp Glu Leu Leu Ile Arg Ala Thr Phe Ser Ser Val Pro Leu Ala
Ala 1490 1495 1500 Ser Ile Ser Ala Val Ser Leu Glu Val Ala Gln Pro
Gly Pro Ser Asn 1505 1510 1515 1520 Arg Pro Arg Ala Leu Glu Val Glu
Glu Cys Arg Cys Pro Pro Gly Tyr 1525 1530 1535 Ile Gly Leu Ser Cys
Gln Asp Cys Ala Pro Gly Tyr Thr Arg Thr Gly 1540 1545 1550 Ser Gly
Leu Tyr Leu Gly His Cys Glu Leu Cys Glu Cys Asn Gly His 1555 1560
1565 Ser Asp Leu Cys His Pro Glu Thr Gly Ala Cys Ser Gln Cys Gln
His 1570 1575 1580 Asn Ala Ala Gly Glu Phe Cys Glu Leu Cys Ala Pro
Gly Tyr Tyr Gly 1585 1590 1595 1600 Asp Ala Thr Ala Gly Thr Pro Glu
Asp Cys Gln Pro Cys Ala Cys Pro 1605 1610 1615 Leu Thr Asn Pro Glu
Asn Met Phe Ser Arg Thr Cys Glu Ser Leu Gly 1620 1625 1630 Ala Gly
Gly Tyr Arg Cys Thr Ala Cys Glu Pro Gly Tyr Thr Gly Gln 1635 1640
1645 Tyr Cys Glu Gln Cys Gly Pro Gly Tyr Val Gly Asn Pro Ser Val
Gln 1650 1655 1660 Gly Gly Gln Cys Leu Pro Glu Thr Asn Gln Ala Pro
Leu Val Val Glu 1665 1670 1675 1680 Val His Pro Ala Arg Ser Ile Val
Pro Gln Gly Gly Ser His Ser Leu 1685 1690 1695 Arg Cys Gln Val Ser
Gly Ser Pro Pro His Tyr Phe Tyr Trp Ser Arg 1700 1705 1710 Glu Asp
Gly Arg Pro Val Pro Ser Gly Thr Gln Gln Arg His Gln Gly 1715 1720
1725 Ser Glu Leu His Phe Pro Ser Val Gln Pro Ser Asp Ala Gly Val
Tyr 1730 1735 1740 Ile Cys Thr Cys Arg Asn Leu His Gln Ser Asn Thr
Ser Arg Ala Glu 1745 1750 1755 1760 Leu Leu Val Thr Glu Ala Pro Ser
Lys Pro Ile Thr Val Thr Val Glu 1765 1770 1775 Glu Gln Arg Ser Gln
Ser Val Arg Pro Gly Ala Asp Val Thr Phe Ile 1780 1785 1790 Cys Thr
Ala Lys Ser Lys Ser Pro Ala Tyr Thr Leu Val Trp Thr Arg 1795 1800
1805 Leu His Asn Gly Lys Leu Pro Thr Arg Ala Met Asp Phe Asn Gly
Ile 1810 1815 1820 Leu Thr Ile Arg Asn Val Gln Leu Ser Asp Ala Gly
Thr Tyr Val Cys 1825 1830 1835 1840 Thr Gly Ser Asn Met Phe Ala Met
Asp Gln Gly Thr Ala Thr Leu His 1845 1850 1855 Val Gln Ala Ser Gly
Thr Leu Ser Ala Pro Val Val Ser Ile His Pro 1860 1865 1870 Pro Gln
Leu Thr Val Gln Pro Gly Gln Leu Ala Glu Phe Arg Cys Ser 1875 1880
1885 Ala Thr Gly Ser Pro Thr Pro Thr Leu Glu Trp Thr Gly Gly Pro
Gly 1890 1895 1900 Gly Gln Leu Pro Ala Lys Ala Gln Ile His Gly Gly
Ile Leu Arg Leu 1905 1910 1915 1920 Pro Ala Val Glu Pro Thr Asp Gln
Ala Gln Tyr Leu Cys Arg Ala His 1925 1930 1935 Ser Ser Ala Gly Gln
Gln Val Ala Arg Ala Val Leu His Val His Gly 1940 1945 1950 Gly Gly
Gly Pro Arg Val Gln Val Ser Pro Glu Arg Thr Gln Val His 1955 1960
1965 Ala Gly Arg Thr Val Arg Leu Tyr Cys Arg Ala Ala Gly Val Pro
Ser 1970 1975 1980 Ala Thr Ile Thr Trp Arg Lys Glu Gly Gly Ser Leu
Pro Pro Gln Ala 1985 1990 1995 2000 Arg Ser Glu Arg Thr Asp Ile Ala
Thr Leu Leu Ile Pro Ala Ile Thr 2005 2010 2015 Thr Ala Asp Ala Gly
Phe Tyr Leu Cys Val Ala Thr Ser Pro Ala Gly 2020 2025 2030 Thr Ala
Gln Ala Arg Ile Gln Val Val Val Leu Ser Ala Ser Asp Ala 2035 2040
2045 Ser Pro Pro Pro Val Lys Ile Glu Ser Ser Ser Pro Ser Val Thr
Glu 2050 2055 2060 Gly Gln Thr Leu Asp Leu Asn Cys Val Val Ala Gly
Ser Ala His Ala 2065 2070 2075 2080 Gln Val Thr Trp Tyr Arg Arg Gly
Gly Ser Leu Pro Pro His Thr Gln 2085 2090 2095 Val His Gly Ser Arg
Leu Arg Leu Pro Gln Val Ser Pro Ala Asp Ser 2100 2105 2110 Gly Glu
Tyr Val Cys Arg Val Glu Asn Gly Ser Gly Pro Lys Glu Ala 2115 2120
2125 Ser Ile Thr Val Ser Val Leu His Gly Thr His Ser Gly Pro Ser
Tyr 2130 2135 2140 Thr Pro Val Pro Gly Ser Thr Arg Pro Ile Arg Ile
Glu Pro Ser Ser 2145 2150 2155 2160 Ser His Val Ala Glu Gly Gln Thr
Leu Asp Leu Asn Cys Val Val Pro 2165 2170 2175 Gly Gln Ala His Ala
Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu 2180 2185 2190 Pro Ala
Arg His Gln Thr His Gly Ser Leu Leu Arg Leu His Gln Val 2195 2200
2205 Thr Pro Ala Asp Ser Gly Glu Tyr Val Cys His Val Val Gly Thr
Ser
2210 2215 2220 Gly Pro Leu Glu Ala Ser Val Leu Val Thr Ile Glu Ala
Ser Val Ile 2225 2230 2235 2240 Pro Gly Pro Ile Pro Pro Val Arg Ile
Glu Ser Ser Ser Ser Thr Val 2245 2250 2255 Ala Glu Gly Gln Thr Leu
Asp Leu Ser Cys Val Val Ala Gly Gln Ala 2260 2265 2270 His Ala Gln
Val Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ala Arg 2275 2280 2285
His Gln Val Arg Gly Ser Arg Leu Tyr Ile Phe Gln Ala Ser Pro Ala
2290 2295 2300 Asp Ala Gly Gln Tyr Val Cys Arg Ala Ser Asn Gly Met
Glu Ala Ser 2305 2310 2315 2320 Ile Thr Val Thr Val Thr Gly Thr Gln
Gly Ala Asn Leu Ala Tyr Pro 2325 2330 2335 Ala Gly Ser Thr Gln Pro
Ile Arg Ile Glu Pro Ser Ser Ser Gln Val 2340 2345 2350 Ala Glu Gly
Gln Thr Leu Asp Leu Asn Cys Val Val Pro Gly Gln Ser 2355 2360 2365
His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Val Arg
2370 2375 2380 His Gln Thr His Gly Ser Leu Leu Arg Leu Tyr Gln Ala
Ser Pro Ala 2385 2390 2395 2400 Asp Ser Gly Glu Tyr Val Cys Arg Val
Leu Gly Ser Ser Val Pro Leu 2405 2410 2415 Glu Ala Ser Val Leu Val
Thr Ile Glu Pro Ala Gly Ser Val Pro Ala 2420 2425 2430 Leu Gly Val
Thr Pro Thr Val Arg Ile Glu Ser Ser Ser Ser Gln Val 2435 2440 2445
Ala Glu Gly Gln Thr Leu Asp Leu Asn Cys Leu Val Ala Gly Gln Ala
2450 2455 2460 His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu
Pro Ala Arg 2465 2470 2475 2480 His Gln Val His Gly Ser Arg Leu Arg
Leu Leu Gln Val Thr Pro Ala 2485 2490 2495 Asp Ser Gly Glu Tyr Val
Cys Arg Val Val Gly Ser Ser Gly Thr Gln 2500 2505 2510 Glu Ala Ser
Val Leu Val Thr Ile Gln Gln Arg Leu Ser Gly Ser His 2515 2520 2525
Ser Gln Gly Val Ala Tyr Pro Val Arg Ile Glu Ser Ser Ser Ala Ser
2530 2535 2540 Leu Ala Asn Gly His Thr Leu Asp Leu Asn Cys Leu Val
Ala Ser Gln 2545 2550 2555 2560 Ala Pro His Thr Ile Thr Trp Tyr Lys
Arg Gly Gly Ser Leu Pro Ser 2565 2570 2575 Arg His Gln Ile Val Gly
Ser Arg Leu Arg Ile Pro Gln Val Thr Pro 2580 2585 2590 Ala Asp Ser
Gly Glu Tyr Val Cys His Val Ser Asn Gly Ala Gly Ser 2595 2600 2605
Arg Glu Thr Ser Leu Ile Val Thr Ile Gln Gly Ser Gly Ser Ser His
2610 2615 2620 Val Pro Ser Val Ser Pro Pro Ile Arg Ile Glu Ser Ser
Ser Pro Thr 2625 2630 2635 2640 Val Val Glu Gly Gln Thr Leu Asp Leu
Asn Cys Val Val Ala Arg Gln 2645 2650 2655 Pro Gln Ala Ile Ile Thr
Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ser 2660 2665 2670 Arg His Gln
Thr His Gly Ser His Leu Arg Leu His Gln Met Ser Val 2675 2680 2685
Ala Asp Ser Gly Glu Tyr Val Cys Arg Ala Asn Asn Asn Ile Asp Ala
2690 2695 2700 Leu Glu Ala Ser Ile Val Ile Ser Val Ser Pro Ser Ala
Gly Ser Pro 2705 2710 2715 2720 Ser Ala Pro Gly Ser Ser Met Pro Ile
Arg Ile Glu Ser Ser Ser Ser 2725 2730 2735 His Val Ala Glu Gly Glu
Thr Leu Asp Leu Asn Cys Val Val Pro Gly 2740 2745 2750 Gln Ala His
Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro 2755 2760 2765
Ser His His Gln Thr Arg Gly Ser Arg Leu Arg Leu His His Val Ser
2770 2775 2780 Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg Val Met Gly
Ser Ser Gly 2785 2790 2795 2800 Pro Leu Glu Ala Ser Val Leu Val Thr
Ile Glu Ala Ser Gly Ser Ser 2805 2810 2815 Ala Val His Val Pro Ala
Pro Gly Gly Ala Pro Pro Ile Arg Ile Glu 2820 2825 2830 Pro Ser Ser
Ser Arg Val Ala Glu Gly Gln Thr Leu Asp Leu Lys Cys 2835 2840 2845
Val Val Pro Gly Gln Ala His Ala Gln Val Thr Trp His Lys Arg Gly
2850 2855 2860 Gly Asn Leu Pro Ala Arg His Gln Val His Gly Pro Leu
Leu Arg Leu 2865 2870 2875 2880 Asn Gln Val Ser Pro Ala Asp Ser Gly
Glu Tyr Ser Cys Gln Val Thr 2885 2890 2895 Gly Ser Ser Gly Thr Leu
Glu Ala Ser Val Leu Val Thr Ile Glu Pro 2900 2905 2910 Ser Ser Pro
Gly Pro Ile Pro Ala Pro Gly Leu Ala Gln Pro Ile Tyr 2915 2920 2925
Ile Glu Ala Ser Ser Ser His Val Thr Glu Gly Gln Thr Leu Asp Leu
2930 2935 2940 Asn Cys Val Val Pro Gly Gln Ala His Ala Gln Val Thr
Trp Tyr Lys 2945 2950 2955 2960 Arg Gly Gly Ser Leu Pro Ala Arg His
Gln Thr His Gly Ser Gln Leu 2965 2970 2975 Arg Leu His Leu Val Ser
Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg 2980 2985 2990 Ala Ala Ser
Gly Pro Gly Pro Glu Gln Glu Ala Ser Phe Thr Val Thr 2995 3000 3005
Val Pro Pro Ser Glu Gly Ser Ser Tyr Arg Leu Arg Ser Pro Val Ile
3010 3015 3020 Ser Ile Asp Pro Pro Ser Ser Thr Val Gln Gln Gly Gln
Asp Ala Ser 3025 3030 3035 3040 Phe Lys Cys Leu Ile His Asp Gly Ala
Ala Pro Ile Ser Leu Glu Trp 3045 3050 3055 Lys Thr Arg Asn Gln Glu
Leu Glu Asp Asn Val His Ile Ser Pro Asn 3060 3065 3070 Gly Ser Ile
Ile Thr Ile Val Gly Thr Arg Pro Ser Asn His Gly Thr 3075 3080 3085
Tyr Arg Cys Val Ala Ser Asn Ala Tyr Gly Val Ala Gln Ser Val Val
3090 3095 3100 Asn Leu Ser Val His Gly Pro Pro Thr Val Ser Val Leu
Pro Glu Gly 3105 3110 3115 3120 Pro Val Trp Val Lys Val Gly Lys Ala
Val Thr Leu Glu Cys Val Ser 3125 3130 3135 Ala Gly Glu Pro Arg Ser
Ser Ala Arg Trp Thr Arg Ile Ser Ser Thr 3140 3145 3150 Pro Ala Lys
Leu Glu Gln Arg Thr Tyr Gly Leu Met Asp Ser His Ala 3155 3160 3165
Val Leu Gln Ile Ser Ser Ala Lys Pro Ser Asp Ala Gly Thr Tyr Val
3170 3175 3180 Cys Leu Ala Gln Asn Ala Leu Gly Thr Ala Gln Lys Gln
Val Glu Val 3185 3190 3195 3200 Ile Val Asp Thr Gly Ala Met Ala Pro
Gly Ala Pro Gln Val Gln Ala 3205 3210 3215 Glu Glu Ala Glu Leu Thr
Val Glu Ala Gly His Thr Ala Thr Leu Arg 3220 3225 3230 Cys Ser Ala
Thr Gly Ser Pro Ala Pro Thr Ile His Trp Ser Lys Leu 3235 3240 3245
Arg Ser Pro Leu Pro Trp Gln His Arg Leu Glu Gly Asp Thr Leu Ile
3250 3255 3260 Ile Pro Arg Val Ala Gln Gln Asp Ser Gly Gln Tyr Ile
Cys Asn Ala 3265 3270 3275 3280 Thr Ser Pro Ala Gly His Ala Glu Ala
Thr Ile Ile Leu His Val Glu 3285 3290 3295 Ser Pro Pro Tyr Ala Thr
Thr Val Pro Glu His Ala Ser Val Gln Ala 3300 3305 3310 Gly Glu Thr
Val Gln Leu Gln Cys Leu Ala His Gly Thr Pro Pro Leu 3315 3320 3325
Thr Phe Gln Trp Ser Arg Val Gly Ser Ser Leu Pro Gly Arg Ala Thr
3330 3335 3340 Ala Arg Asn Glu Leu Leu His Phe Glu Arg Ala Ala Pro
Glu Asp Ser 3345 3350 3355 3360 Gly Arg Tyr Arg Cys Arg Val Thr Asn
Lys Val Gly Ser Ala Glu Ala 3365 3370 3375 Phe Ala Gln Leu Leu Val
Gln Gly Pro Pro Gly Ser Leu Pro Ala Thr 3380 3385 3390 Ser Ile Pro
Ala Gly Ser Thr Pro Thr Val Gln Val Thr Pro Gln Leu 3395 3400 3405
Glu Thr Lys Ser Ile Gly Ala Ser Val Glu Phe His Cys Ala Val Pro
3410 3415 3420 Ser Asp Arg Gly Thr Gln Leu Arg Trp Phe Lys Glu Gly
Gly Gln Leu 3425 3430 3435 3440 Pro Pro Gly His Ser Val Gln Asp Gly
Val Leu Arg Ile Gln Asn Leu 3445 3450 3455 Asp Gln Ser Cys Gln Gly
Thr Tyr Ile Cys Gln Ala His Gly Pro Trp 3460 3465 3470 Gly Lys Ala
Gln Ala Ser Ala Gln Leu Val Ile Gln Ala Leu Pro Ser 3475 3480 3485
Val Leu Ile Asn Ile Arg Thr Ser Val Gln Thr Val Val Val Gly His
3490 3495 3500 Ala Val Glu Phe Glu Cys Leu Ala Leu Gly Asp Pro Lys
Pro Gln Val 3505 3510 3515 3520 Thr Trp Ser Lys Val Gly Gly His Leu
Arg Pro Gly Ile Val Gln Ser 3525 3530 3535 Gly Gly Val Val Arg Ile
Ala His Val Glu Leu Ala Asp Ala Gly Gln 3540 3545 3550
Tyr Arg Cys Thr Ala Thr Asn Ala Ala Gly Thr Thr Gln Ser His Val
3555 3560 3565 Leu Leu Leu Val Gln Ala Leu Pro Gln Ile Ser Met Pro
Gln Glu Val 3570 3575 3580 Arg Val Pro Ala Gly Ser Ala Ala Val Phe
Pro Cys Ile Ala Ser Gly 3585 3590 3595 3600 Tyr Pro Thr Pro Asp Ile
Ser Trp Ser Lys Leu Asp Gly Ser Leu Pro 3605 3610 3615 Pro Asp Ser
Arg Leu Glu Asn Asn Met Leu Met Leu Pro Ser Val Arg 3620 3625 3630
Pro Gln Asp Ala Gly Thr Tyr Val Cys Thr Ala Thr Asn Arg Gln Gly
3635 3640 3645 Lys Val Lys Ala Phe Ala His Leu Gln Val Pro Glu Arg
Val Val Pro 3650 3655 3660 Tyr Phe Thr Gln Thr Pro Tyr Ser Phe Leu
Pro Leu Pro Thr Ile Lys 3665 3670 3675 3680 Asp Ala Tyr Arg Lys Phe
Glu Ile Lys Ile Thr Phe Arg Pro Asp Ser 3685 3690 3695 Ala Asp Gly
Met Leu Leu Tyr Asn Gly Gln Lys Arg Val Pro Gly Ser 3700 3705 3710
Pro Thr Asn Leu Ala Asn Arg Gln Pro Asp Phe Ile Ser Phe Gly Leu
3715 3720 3725 Val Gly Gly Arg Pro Glu Phe Arg Phe Asp Ala Gly Ser
Gly Met Ala 3730 3735 3740 Thr Ile Arg His Pro Thr Pro Leu Ala Leu
Gly His Phe His Thr Val 3745 3750 3755 3760 Thr Leu Leu Arg Ser Leu
Thr Gln Gly Ser Leu Ile Val Gly Asp Leu 3765 3770 3775 Ala Pro Val
Asn Gly Thr Ser Gln Gly Lys Phe Gln Gly Leu Asp Leu 3780 3785 3790
Asn Glu Glu Leu Tyr Leu Gly Gly Tyr Pro Asp Tyr Gly Ala Ile Pro
3795 3800 3805 Lys Ala Gly Leu Ser Ser Gly Phe Ile Gly Cys Val Arg
Glu Leu Arg 3810 3815 3820 Ile Gln Gly Glu Glu Ile Val Phe His Asp
Leu Asn Leu Thr Ala His 3825 3830 3835 3840 Gly Ile Ser His Cys Pro
Thr Cys Arg Asp Arg Pro Cys Gln Asn Gly 3845 3850 3855 Gly Gln Cys
His Asp Ser Glu Ser Ser Ser Tyr Val Cys Val Cys Pro 3860 3865 3870
Ala Gly Phe Thr Gly Ser Arg Cys Glu His Ser Gln Ala Leu His Cys
3875 3880 3885 His Pro Glu Ala Cys Gly Pro Asp Ala Thr Cys Val Asn
Arg Pro Asp 3890 3895 3900 Gly Arg Gly Tyr Thr Cys Arg Cys His Leu
Gly Arg Ser Gly Leu Arg 3905 3910 3915 3920 Cys Glu Glu Gly Val Thr
Val Thr Thr Pro Ser Leu Ser Gly Ala Gly 3925 3930 3935 Ser Tyr Leu
Ala Leu Pro Ala Leu Thr Asn Thr His His Glu Leu Arg 3940 3945 3950
Leu Asp Val Glu Phe Lys Pro Leu Ala Pro Asp Gly Val Leu Leu Phe
3955 3960 3965 Ser Gly Gly Lys Ser Gly Pro Val Glu Asp Phe Val Ser
Leu Ala Met 3970 3975 3980 Val Gly Gly His Leu Glu Phe Arg Tyr Glu
Leu Gly Ser Gly Leu Ala 3985 3990 3995 4000 Val Leu Arg Ser Ala Glu
Pro Leu Ala Leu Gly Arg Trp His Arg Val 4005 4010 4015 Ser Ala Glu
Arg Leu Asn Lys Asp Gly Ser Leu Arg Val Asn Gly Gly 4020 4025 4030
Arg Pro Val Leu Arg Ser Ser Pro Gly Lys Ser Gln Gly Leu Asn Leu
4035 4040 4045 His Thr Leu Leu Tyr Leu Gly Gly Val Glu Pro Ser Val
Pro Leu Ser 4050 4055 4060 Pro Ala Thr Asn Met Ser Ala His Phe Arg
Gly Cys Val Gly Glu Val 4065 4070 4075 4080 Ser Val Asn Gly Lys Arg
Leu Asp Leu Thr Tyr Ser Phe Leu Gly Ser 4085 4090 4095 Gln Gly Ile
Gly Gln Cys Tyr Asp Ser Ser Pro Cys Glu Arg Gln Pro 4100 4105 4110
Cys Gln His Gly Ala Thr Cys Met Pro Ala Gly Glu Tyr Glu Phe Gln
4115 4120 4125 Cys Leu Cys Arg Asp Gly Phe Lys Gly Asp Leu Cys Glu
His Glu Glu 4130 4135 4140 Asn Pro Cys Gln Leu Arg Glu Pro Cys Leu
His Gly Gly Thr Cys Gln 4145 4150 4155 4160 Gly Thr Arg Cys Leu Cys
Leu Pro Gly Phe Ser Gly Pro Arg Cys Gln 4165 4170 4175 Gln Gly Ser
Gly His Gly Ile Ala Glu Ser Asp Trp His Leu Glu Gly 4180 4185 4190
Ser Gly Gly Asn Asp Ala Pro Gly Gln Tyr Gly Ala Tyr Phe His Asp
4195 4200 4205 Asp Gly Phe Leu Ala Phe Pro Gly His Val Phe Ser Arg
Ser Leu Pro 4210 4215 4220 Glu Val Pro Glu Thr Ile Glu Leu Glu Val
Arg Thr Ser Thr Ala Ser 4225 4230 4235 4240 Gly Leu Leu Leu Trp Gln
Gly Val Glu Val Gly Glu Ala Gly Gln Gly 4245 4250 4255 Lys Asp Phe
Ile Ser Leu Gly Leu Gln Asp Gly His Leu Val Phe Arg 4260 4265 4270
Tyr Gln Leu Gly Ser Gly Glu Ala Arg Leu Val Ser Glu Asp Pro Ile
4275 4280 4285 Asn Asp Gly Glu Trp His Arg Val Thr Ala Leu Arg Glu
Gly Arg Arg 4290 4295 4300 Gly Ser Ile Gln Val Asp Gly Glu Glu Leu
Val Ser Gly Arg Ser Pro 4305 4310 4315 4320 Gly Pro Asn Val Ala Val
Asn Ala Lys Gly Ser Val Tyr Ile Gly Gly 4325 4330 4335 Ala Pro Asp
Val Ala Thr Leu Thr Gly Gly Arg Phe Ser Ser Gly Ile 4340 4345 4350
Thr Gly Cys Val Lys Asn Leu Val Leu His Ser Ala Arg Pro Gly Ala
4355 4360 4365 Pro Pro Pro Gln Pro Leu Asp Leu Gln His Arg Ala Gln
Ala Gly Ala 4370 4375 4380 Asn Thr Arg Pro Cys Pro Ser 4385 4390
<210> SEQ ID NO 90 <211> LENGTH: 198 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Met
Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 1 5 10
15 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val
20 25 30 Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe
Gly Tyr 35 40 45 Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu
Phe Leu Arg Tyr 50 55 60 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg
Cys Tyr Arg Val Thr Trp 65 70 75 80 Phe Thr Ser Trp Ser Pro Cys Tyr
Asp Cys Ala Arg His Val Ala Asp 85 90 95 Phe Leu Arg Gly Asn Pro
Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 100 105 110 Leu Tyr Phe Cys
Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 115 120 125 Leu His
Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 130 135 140
Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 145
150 155 160 Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg
Gln Leu 165 170 175 Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp
Leu Arg Asp Ala 180 185 190 Phe Arg Thr Leu Gly Leu 195 <210>
SEQ ID NO 91 <211> LENGTH: 491 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 91 Met Glu
Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 1 5 10 15
Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 20
25 30 Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp
Arg 35 40 45 Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys
Tyr Gly Asp 50 55 60 Val Phe Thr Val His Leu Gly Pro Arg Pro Val
Val Met Leu Cys Gly 65 70 75 80 Val Glu Ala Ile Arg Glu Ala Leu Val
Asp Lys Ala Glu Ala Phe Ser 85 90 95 Gly Arg Gly Lys Ile Ala Met
Val Asp Pro Phe Phe Arg Gly Tyr Gly 100 105 110 Val Ile Phe Ala Asn
Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 115 120 125 Val Thr Thr
Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 130 135 140 Arg
Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 145 150
155 160 Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr
Ala 165 170 175 Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His
Tyr Gln Asp 180 185 190 Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr
Gln Thr Phe Ser Leu
195 200 205 Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly
Phe Leu 210 215 220 Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys
Asn Leu Gln Glu 225 230 235 240 Ile Asn Ala Tyr Ile Gly His Ser Val
Glu Lys His Arg Glu Thr Leu 245 250 255 Asp Pro Ser Ala Pro Lys Asp
Leu Ile Asp Thr Tyr Leu Leu His Met 260 265 270 Glu Lys Glu Lys Ser
Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 275 280 285 Asn Leu Asn
Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 290 295 300 Thr
Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 305 310
315 320 Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His
Arg 325 330 335 Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr
Glu Ala Val 340 345 350 Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu
Pro Met Gly Val Pro 355 360 365 His Ile Val Thr Gln His Thr Ser Phe
Arg Gly Tyr Ile Ile Pro Lys 370 375 380 Asp Thr Glu Val Phe Leu Ile
Leu Ser Thr Ala Leu His Asp Pro His 385 390 395 400 Tyr Phe Glu Lys
Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 405 410 415 Asn Gly
Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 420 425 430
Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 435
440 445 Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val
Ala 450 455 460 Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val
Gly Lys Ile 465 470 475 480 Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro
Arg 485 490 <210> SEQ ID NO 92 <211> LENGTH: 454
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 92 Met Asp Phe Phe Arg Val Val Glu Asn Gln
Gln Pro Pro Ala Thr Met 1 5 10 15 Pro Leu Asn Val Ser Phe Thr Asn
Arg Asn Tyr Asp Leu Asp Tyr Asp 20 25 30 Ser Val Gln Pro Tyr Phe
Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 35 40 45 Gln Gln Gln Gln
Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 50 55 60 Trp Lys
Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 65 70 75 80
Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 85
90 95 Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
Asp 100 105 110 Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met
Val Asn Gln 115 120 125 Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe
Ile Lys Asn Ile Ile 130 135 140 Ile Gln Asp Cys Met Trp Ser Gly Phe
Ser Ala Ala Ala Lys Leu Val 145 150 155 160 Ser Glu Lys Leu Ala Ser
Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 165 170 175 Pro Asn Pro Ala
Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 180 185 190 Leu Gln
Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 195 200 205
Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 210
215 220 Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
Ser 225 230 235 240 Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro
Leu Val Leu His 245 250 255 Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp
Ser Glu Glu Glu Gln Glu 260 265 270 Asp Glu Glu Glu Ile Asp Val Val
Ser Val Glu Lys Arg Gln Ala Pro 275 280 285 Gly Lys Arg Ser Glu Ser
Gly Ser Pro Ser Ala Gly Gly His Ser Lys 290 295 300 Pro Pro His Ser
Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 305 310 315 320 Gln
His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 325 330
335 Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser
340 345 350 Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu
Glu Asn 355 360 365 Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln
Arg Arg Asn Glu 370 375 380 Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp
Gln Ile Pro Glu Leu Glu 385 390 395 400 Asn Asn Glu Lys Ala Pro Lys
Val Val Ile Leu Lys Lys Ala Thr Ala 405 410 415 Tyr Ile Leu Ser Val
Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 420 425 430 Asp Leu Leu
Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 435 440 445 Leu
Arg Asn Ser Cys Ala 450 <210> SEQ ID NO 93 <211>
LENGTH: 894 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 93 Met Ile Leu Leu Ala Val Leu Phe
Leu Cys Phe Ile Ser Ser Tyr Ser 1 5 10 15 Ala Ser Val Lys Gly His
Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 20 25 30 Leu Tyr Lys Leu
Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 35 40 45 Gly Lys
Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 50 55 60
Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 65
70 75 80 Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln
Gln Arg 85 90 95 Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser
Lys Ile Met Gly 100 105 110 Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro
Thr Leu Leu His Leu Ile 115 120 125 His Gly Lys Val Lys Glu Phe Tyr
Ser Tyr Gln Asn Glu Ala Val Ala 130 135 140 Ile Glu Asn Ile Lys Arg
Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 145 150 155 160 Ser Ser Gly
Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 165 170 175 Thr
Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 180 185
190 Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu
195 200 205 Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile
Glu Asp 210 215 220 Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His
Asn Phe Gly Leu 225 230 235 240 Asn Phe Leu Gln Thr Ile Lys Gly Lys
Ile Val Ser Lys Gln Lys Leu 245 250 255 Glu Leu Lys Thr Thr Glu Ala
Gly Pro Arg Leu Met Ser Gly Lys Gln 260 265 270 Ala Ala Ala Ile Ile
Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 275 280 285 Ile Val Gly
Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 290 295 300 Ser
Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 305 310
315 320 Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His
Leu 325 330 335 Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys
Met Glu Asn 340 345 350 Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val
Thr Ser Ala Gln Thr 355 360 365 Ser Asp Ser Leu Glu Ala Ile Leu Asp
Phe Leu Asp Phe Lys Ser Asp 370 375 380 Ser Ser Ile Ile Leu Gln Glu
Arg Phe Leu Tyr Ala Cys Gly Phe Ala 385 390 395 400 Ser His Pro Asn
Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 405 410 415 Gly Ser
Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 420 425 430
Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 435
440 445 Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys
Ala 450 455 460 Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu
Lys Asn Ala 465 470 475 480 Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu
Lys Tyr Ala Glu Ala Gly 485 490 495
Glu Gly Pro Ile Ser His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp 500
505 510 Leu Pro Phe Ile Thr Asp Glu Val Lys Lys Thr Leu Asn Arg Ile
Tyr 515 520 525 His Gln Asn Arg Lys Val His Glu Lys Thr Val Arg Thr
Ala Ala Ala 530 535 540 Ala Ile Ile Leu Asn Asn Asn Pro Ser Tyr Met
Asp Val Lys Asn Ile 545 550 555 560 Leu Leu Ser Ile Gly Glu Leu Pro
Gln Glu Met Asn Lys Tyr Met Leu 565 570 575 Ala Ile Val Gln Asp Ile
Leu Arg Phe Glu Met Pro Ala Ser Lys Ile 580 585 590 Val Arg Arg Val
Leu Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe 595 600 605 Ser Arg
Ser Gly Ser Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser 610 615 620
Pro Arg Ser Ala Ser Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser 625
630 635 640 Gly Ile Leu Arg Arg Ser Asn Leu Asn Ile Phe Gln Tyr Ile
Gly Lys 645 650 655 Ala Gly Leu His Gly Ser Gln Val Val Ile Glu Ala
Gln Gly Leu Glu 660 665 670 Ala Leu Ile Ala Ala Thr Pro Asp Glu Gly
Glu Glu Asn Leu Asp Ser 675 680 685 Tyr Ala Gly Met Ser Ala Ile Leu
Phe Asp Val Gln Leu Arg Pro Val 690 695 700 Thr Phe Phe Asn Gly Tyr
Ser Asp Leu Met Ser Lys Met Leu Ser Ala 705 710 715 720 Ser Gly Asp
Pro Ile Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp 725 730 735 His
Ser Gln Glu Leu Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu 740 745
750 Val Gln Gly Gly Leu Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser
755 760 765 Leu Trp Tyr Arg Glu Ser Lys Thr Arg Val Lys Asn Arg Val
Thr Val 770 775 780 Val Ile Thr Thr Asp Ile Thr Val Asp Ser Ser Phe
Val Lys Ala Gly 785 790 795 800 Leu Glu Thr Ser Thr Glu Thr Glu Ala
Gly Leu Glu Phe Ile Ser Thr 805 810 815 Val Gln Phe Ser Gln Tyr Pro
Phe Leu Val Cys Met Gln Met Asp Lys 820 825 830 Asp Glu Ala Pro Phe
Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser 835 840 845 Thr Gly Arg
Gly Tyr Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala 850 855 860 Gly
Cys Glu Phe Pro Leu His Gln Glu Asn Ser Glu Met Cys Lys Val 865 870
875 880 Val Phe Ala Pro Gln Pro Asp Ser Thr Ser Ser Gly Trp Phe 885
890 <210> SEQ ID NO 94 <211> LENGTH: 1210 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
94 Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
1 5 10 15 Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val
Cys Gln 20 25 30 Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe
Glu Asp His Phe 35 40 45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys
Glu Val Val Leu Gly Asn 50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg
Asn Tyr Asp Leu Ser Phe Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala
Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro
Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu
Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130
135 140 His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val
Glu 145 150 155 160 Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe
Leu Ser Asn Met 165 170 175 Ser Met Asp Phe Gln Asn His Leu Gly Ser
Cys Gln Lys Cys Asp Pro 180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp
Gly Ala Gly Glu Glu Asn Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile
Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro
Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr
Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250
255 Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
260 265 270 Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser
Phe Gly 275 280 285 Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val
Val Thr Asp His 290 295 300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp
Ser Tyr Glu Met Glu Glu 305 310 315 320 Asp Gly Val Arg Lys Cys Lys
Lys Cys Glu Gly Pro Cys Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly
Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn
Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 355 360 365 Leu
His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 370 375
380 Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385 390 395 400 Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
Arg Thr Asp 405 410 415 Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg
Gly Arg Thr Lys Gln 420 425 430 His Gly Gln Phe Ser Leu Ala Val Val
Ser Leu Asn Ile Thr Ser Leu 435 440 445 Gly Leu Arg Ser Leu Lys Glu
Ile Ser Asp Gly Asp Val Ile Ile Ser 450 455 460 Gly Asn Lys Asn Leu
Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 465 470 475 480 Phe Gly
Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 485 490 495
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 500
505 510 Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg
Asn 515 520 525 Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
Leu Glu Gly 530 535 540 Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys
Ile Gln Cys His Pro 545 550 555 560 Glu Cys Leu Pro Gln Ala Met Asn
Ile Thr Cys Thr Gly Arg Gly Pro 565 570 575 Asp Asn Cys Ile Gln Cys
Ala His Tyr Ile Asp Gly Pro His Cys Val 580 585 590 Lys Thr Cys Pro
Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 595 600 605 Lys Tyr
Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 610 615 620
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 625
630 635 640 Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu
Leu Leu 645 650 655 Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
Arg Arg Arg His 660 665 670 Ile Val Arg Lys Arg Thr Leu Arg Arg Leu
Leu Gln Glu Arg Glu Leu 675 680 685 Val Glu Pro Leu Thr Pro Ser Gly
Glu Ala Pro Asn Gln Ala Leu Leu 690 695 700 Arg Ile Leu Lys Glu Thr
Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 705 710 715 720 Gly Ala Phe
Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 725 730 735 Lys
Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 740 745
750 Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
755 760 765 Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu
Thr Ser 770 775 780 Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly
Cys Leu Leu Asp 785 790 795 800 Tyr Val Arg Glu His Lys Asp Asn Ile
Gly Ser Gln Tyr Leu Leu Asn 805 810 815 Trp Cys Val Gln Ile Ala Lys
Gly Met Asn Tyr Leu Glu Asp Arg Arg 820 825 830 Leu Val His Arg Asp
Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 835 840 845 Gln His Val
Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 850 855 860 Glu
Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 865 870
875 880 Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser
Asp 885 890 895
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 900
905 910 Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu
Glu 915 920 925 Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile
Asp Val Tyr 930 935 940 Met Ile Met Val Lys Cys Trp Met Ile Asp Ala
Asp Ser Arg Pro Lys 945 950 955 960 Phe Arg Glu Leu Ile Ile Glu Phe
Ser Lys Met Ala Arg Asp Pro Gln 965 970 975 Arg Tyr Leu Val Ile Gln
Gly Asp Glu Arg Met His Leu Pro Ser Pro 980 985 990 Thr Asp Ser Asn
Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp 995 1000 1005 Asp
Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe 1010
1015 1020 Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu
Ser Ala 1025 1030 1035 1040 Thr Ser Asn Asn Ser Thr Val Ala Cys Ile
Asp Arg Asn Gly Leu Gln 1045 1050 1055 Ser Cys Pro Ile Lys Glu Asp
Ser Phe Leu Gln Arg Tyr Ser Ser Asp 1060 1065 1070 Pro Thr Gly Ala
Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro 1075 1080 1085 Val
Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 1090
1095 1100 Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala
Pro Ser 1105 1110 1115 1120 Arg Asp Pro His Tyr Gln Asp Pro His Ser
Thr Ala Val Gly Asn Pro 1125 1130 1135 Glu Tyr Leu Asn Thr Val Gln
Pro Thr Cys Val Asn Ser Thr Phe Asp 1140 1145 1150 Ser Pro Ala His
Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp 1155 1160 1165 Asn
Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn 1170
1175 1180 Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu
Arg Val 1185 1190 1195 1200 Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
1205 1210 <210> SEQ ID NO 95 <211> LENGTH: 705
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 95 Met Arg Pro Ser Gly Thr Ala Gly Ala Ala
Leu Leu Ala Leu Leu Ala 1 5 10 15 Ala Leu Cys Pro Ala Ser Arg Ala
Leu Glu Glu Lys Lys Val Cys Gln 20 25 30 Gly Thr Ser Asn Lys Leu
Thr Gln Leu Gly Thr Phe Glu Asp His Phe 35 40 45 Leu Ser Leu Gln
Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 50 55 60 Leu Glu
Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 65 70 75 80
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 85
90 95 Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met
Tyr 100 105 110 Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr
Asp Ala Asn 115 120 125 Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn
Leu Gln Glu Ile Leu 130 135 140 His Gly Ala Val Arg Phe Ser Asn Asn
Pro Ala Leu Cys Asn Val Glu 145 150 155 160 Ser Ile Gln Trp Arg Asp
Ile Val Ser Ser Asp Phe Leu Ser Asn Met 165 170 175 Ser Met Asp Phe
Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 180 185 190 Ser Cys
Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 195 200 205
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 210
215 220 Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly
Cys 225 230 235 240 Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg
Lys Phe Arg Asp 245 250 255 Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro
Leu Met Leu Tyr Asn Pro 260 265 270 Thr Thr Tyr Gln Met Asp Val Asn
Pro Glu Gly Lys Tyr Ser Phe Gly 275 280 285 Ala Thr Cys Val Lys Lys
Cys Pro Arg Asn Tyr Val Val Thr Asp His 290 295 300 Gly Ser Cys Val
Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 305 310 315 320 Asp
Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 325 330
335 Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
340 345 350 Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser
Gly Asp 355 360 365 Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser
Phe Thr His Thr 370 375 380 Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile
Leu Lys Thr Val Lys Glu 385 390 395 400 Ile Thr Gly Phe Leu Leu Ile
Gln Ala Trp Pro Glu Asn Arg Thr Asp 405 410 415 Leu His Ala Phe Glu
Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 420 425 430 His Gly Gln
Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 435 440 445 Gly
Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 450 455
460 Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465 470 475 480 Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
Arg Gly Glu 485 490 495 Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His
Ala Leu Cys Ser Pro 500 505 510 Glu Gly Cys Trp Gly Pro Glu Pro Arg
Asp Cys Val Ser Cys Arg Asn 515 520 525 Val Ser Arg Gly Arg Glu Cys
Val Asp Lys Cys Asn Leu Leu Glu Gly 530 535 540 Glu Pro Arg Glu Phe
Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 545 550 555 560 Glu Cys
Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 565 570 575
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 580
585 590 Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val
Trp 595 600 605 Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
Pro Asn Cys 610 615 620 Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala
Met Leu Phe Cys Leu 625 630 635 640 Phe Lys Leu Ser Ser Cys Asn Gln
Ser Asn Asp Gly Ser Val Ser His 645 650 655 Gln Ser Gly Ser Pro Ala
Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 660 665 670 Ser Leu Leu Pro
Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 675 680 685 Leu His
Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 690 695 700
His 705 <210> SEQ ID NO 96 <211> LENGTH: 628
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 96 Met Arg Pro Ser Gly Thr Ala Gly Ala Ala
Leu Leu Ala Leu Leu Ala 1 5 10 15 Ala Leu Cys Pro Ala Ser Arg Ala
Leu Glu Glu Lys Lys Val Cys Gln 20 25 30 Gly Thr Ser Asn Lys Leu
Thr Gln Leu Gly Thr Phe Glu Asp His Phe 35 40 45 Leu Ser Leu Gln
Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 50 55 60 Leu Glu
Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 65 70 75 80
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 85
90 95 Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met
Tyr 100 105 110 Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr
Asp Ala Asn 115 120 125 Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn
Leu Gln Glu Ile Leu 130 135 140 His Gly Ala Val Arg Phe Ser Asn Asn
Pro Ala Leu Cys Asn Val Glu 145 150 155 160 Ser Ile Gln Trp Arg Asp
Ile Val Ser Ser Asp Phe Leu Ser Asn Met 165 170 175 Ser Met Asp Phe
Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 180 185 190 Ser Cys
Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 195 200
205
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 210
215 220 Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly
Cys 225 230 235 240 Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg
Lys Phe Arg Asp 245 250 255 Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro
Leu Met Leu Tyr Asn Pro 260 265 270 Thr Thr Tyr Gln Met Asp Val Asn
Pro Glu Gly Lys Tyr Ser Phe Gly 275 280 285 Ala Thr Cys Val Lys Lys
Cys Pro Arg Asn Tyr Val Val Thr Asp His 290 295 300 Gly Ser Cys Val
Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 305 310 315 320 Asp
Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 325 330
335 Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
340 345 350 Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser
Gly Asp 355 360 365 Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser
Phe Thr His Thr 370 375 380 Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile
Leu Lys Thr Val Lys Glu 385 390 395 400 Ile Thr Gly Phe Leu Leu Ile
Gln Ala Trp Pro Glu Asn Arg Thr Asp 405 410 415 Leu His Ala Phe Glu
Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 420 425 430 His Gly Gln
Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 435 440 445 Gly
Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 450 455
460 Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465 470 475 480 Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
Arg Gly Glu 485 490 495 Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His
Ala Leu Cys Ser Pro 500 505 510 Glu Gly Cys Trp Gly Pro Glu Pro Arg
Asp Cys Val Ser Cys Arg Asn 515 520 525 Val Ser Arg Gly Arg Glu Cys
Val Asp Lys Cys Asn Leu Leu Glu Gly 530 535 540 Glu Pro Arg Glu Phe
Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 545 550 555 560 Glu Cys
Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 565 570 575
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 580
585 590 Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val
Trp 595 600 605 Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
Pro Asn Cys 610 615 620 Thr Tyr Gly Ser 625 <210> SEQ ID NO
97 <211> LENGTH: 242 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 97 Met Ser Gly Cys Asp
Ala Arg Glu Gly Asp Cys Cys Ser Arg Arg Cys 1 5 10 15 Gly Ala Gln
Asp Lys Glu His Pro Arg Tyr Leu Ile Pro Glu Leu Cys 20 25 30 Lys
Gln Phe Tyr His Leu Gly Trp Val Thr Gly Thr Gly Gly Gly Ile 35 40
45 Ser Leu Lys His Gly Asp Glu Ile Tyr Ile Ala Pro Ser Gly Val Gln
50 55 60 Lys Glu Arg Ile Gln Pro Glu Asp Met Phe Val Cys Asp Ile
Asn Glu 65 70 75 80 Lys Asp Ile Ser Gly Pro Ser Pro Ser Lys Lys Leu
Lys Lys Ser Gln 85 90 95 Cys Thr Pro Leu Phe Met Asn Ala Tyr Thr
Met Arg Gly Ala Gly Ala 100 105 110 Val Ile His Thr His Ser Lys Ala
Ala Val Met Ala Thr Leu Leu Phe 115 120 125 Pro Gly Arg Glu Phe Lys
Ile Thr His Gln Glu Met Ile Lys Gly Ile 130 135 140 Lys Lys Cys Thr
Ser Gly Gly Tyr Tyr Arg Tyr Asp Asp Met Leu Val 145 150 155 160 Val
Pro Ile Ile Glu Asn Thr Pro Glu Glu Lys Asp Leu Lys Asp Arg 165 170
175 Met Ala His Ala Met Asn Glu Tyr Pro Asp Ser Cys Ala Val Leu Val
180 185 190 Arg Arg His Gly Val Tyr Val Trp Gly Glu Thr Trp Glu Lys
Ala Lys 195 200 205 Thr Met Cys Glu Cys Tyr Asp Tyr Leu Phe Asp Ile
Ala Val Ser Met 210 215 220 Lys Lys Val Gly Leu Asp Pro Ser Gln Leu
Pro Val Gly Glu Asn Gly 225 230 235 240 Ile Val <210> SEQ ID
NO 98 <211> LENGTH: 367 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 98 Met Arg Trp Phe Leu
Pro Trp Thr Leu Ala Ala Val Thr Ala Ala Ala 1 5 10 15 Ala Ser Thr
Val Leu Ala Thr Ala Leu Ser Pro Ala Pro Thr Thr Met 20 25 30 Asp
Phe Thr Pro Ala Pro Leu Glu Asp Thr Ser Ser Arg Pro Gln Phe 35 40
45 Cys Lys Trp Pro Cys Glu Cys Pro Pro Ser Pro Pro Arg Cys Pro Leu
50 55 60 Gly Val Ser Leu Ile Thr Asp Gly Cys Glu Cys Cys Lys Met
Cys Ala 65 70 75 80 Gln Gln Leu Gly Asp Asn Cys Thr Glu Ala Ala Ile
Cys Asp Pro His 85 90 95 Arg Gly Leu Tyr Cys Asp Tyr Ser Gly Asp
Arg Pro Arg Tyr Ala Ile 100 105 110 Gly Val Cys Ala Gln Val Val Gly
Val Gly Cys Val Leu Asp Gly Val 115 120 125 Arg Tyr Asn Asn Gly Gln
Ser Phe Gln Pro Asn Cys Lys Tyr Asn Cys 130 135 140 Thr Cys Ile Asp
Gly Ala Val Gly Cys Thr Pro Leu Cys Leu Arg Val 145 150 155 160 Arg
Pro Pro Arg Leu Trp Cys Pro His Pro Arg Arg Val Ser Ile Pro 165 170
175 Gly His Cys Cys Glu Gln Trp Val Cys Glu Asp Asp Ala Lys Arg Pro
180 185 190 Arg Lys Thr Ala Pro Arg Asp Thr Gly Ala Phe Asp Ala Val
Gly Glu 195 200 205 Val Glu Ala Trp His Arg Asn Cys Ile Ala Tyr Thr
Ser Pro Trp Ser 210 215 220 Pro Cys Ser Thr Ser Cys Gly Leu Gly Val
Ser Thr Arg Ile Ser Asn 225 230 235 240 Val Asn Ala Gln Cys Trp Pro
Glu Gln Glu Ser Arg Leu Cys Asn Leu 245 250 255 Arg Pro Cys Asp Val
Asp Ile His Thr Leu Ile Lys Ala Gly Lys Lys 260 265 270 Cys Leu Ala
Val Tyr Gln Pro Glu Ala Ser Met Asn Phe Thr Leu Ala 275 280 285 Gly
Cys Ile Ser Thr Arg Ser Tyr Gln Pro Lys Tyr Cys Gly Val Cys 290 295
300 Met Asp Asn Arg Cys Cys Ile Pro Tyr Lys Ser Lys Thr Ile Asp Val
305 310 315 320 Ser Phe Gln Cys Pro Asp Gly Leu Gly Phe Ser Arg Gln
Val Leu Trp 325 330 335 Ile Asn Ala Cys Phe Cys Asn Leu Ser Cys Arg
Asn Pro Asn Asp Ile 340 345 350 Phe Ala Asp Leu Glu Ser Tyr Pro Asp
Phe Ser Glu Ile Ala Asn 355 360 365 <210> SEQ ID NO 99
<211> LENGTH: 280 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 99 Met Arg Trp Phe Leu Pro Trp
Thr Leu Ala Ala Val Thr Ala Ala Ala 1 5 10 15 Ala Ser Thr Val Leu
Ala Thr Ala Leu Ser Pro Ala Pro Thr Thr Met 20 25 30 Asp Phe Thr
Pro Ala Pro Leu Glu Asp Thr Ser Ser Arg Pro Gln Phe 35 40 45 Cys
Lys Trp Pro Cys Glu Cys Pro Pro Ser Pro Pro Arg Cys Pro Leu 50 55
60 Gly Val Ser Leu Ile Thr Asp Gly Cys Glu Cys Cys Lys Met Cys Ala
65 70 75 80 Gln Gln Leu Gly Asp Asn Cys Thr Glu Ala Ala Ile Cys Asp
Pro His 85 90 95 Arg Gly Leu Tyr Cys Asp Tyr Ser Gly Asp Arg Pro
Arg Tyr Ala Ile 100 105 110 Gly Val Cys Ala His Ala Val Gly Glu Val
Glu Ala Trp His Arg Asn 115 120 125 Cys Ile Ala Tyr Thr Ser Pro Trp
Ser Pro Cys Ser Thr Ser Cys Gly 130 135 140 Leu Gly Val Ser Thr Arg
Ile Ser Asn Val Asn Ala Gln Cys Trp Pro 145 150 155 160
Glu Gln Glu Ser Arg Leu Cys Asn Leu Arg Pro Cys Asp Val Asp Ile 165
170 175 His Thr Leu Ile Lys Ala Gly Lys Lys Cys Leu Ala Val Tyr Gln
Pro 180 185 190 Glu Ala Ser Met Asn Phe Thr Leu Ala Gly Cys Ile Ser
Thr Arg Ser 195 200 205 Tyr Gln Pro Lys Tyr Cys Gly Val Cys Met Asp
Asn Arg Cys Cys Ile 210 215 220 Pro Tyr Lys Ser Lys Thr Ile Asp Val
Ser Phe Gln Cys Pro Asp Gly 225 230 235 240 Leu Gly Phe Ser Arg Gln
Val Leu Trp Ile Asn Ala Cys Phe Cys Asn 245 250 255 Leu Ser Cys Arg
Asn Pro Asn Asp Ile Phe Ala Asp Leu Glu Ser Tyr 260 265 270 Pro Asp
Phe Ser Glu Ile Ala Asn 275 280 <210> SEQ ID NO 100
<211> LENGTH: 370 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 100 Met Gly Leu Trp Ala Leu Leu
Pro Gly Trp Val Ser Ala Thr Leu Leu 1 5 10 15 Leu Ala Leu Ala Ala
Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 20 25 30 Arg Trp Trp
Gly Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 35 40 45 Asp
Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 50 55
60 Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His
65 70 75 80 Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys
Trp Gln 85 90 95 Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro
Gly Pro His Leu 100 105 110 Phe Gly Lys Ile Val Asn Arg Gly Cys Arg
Glu Thr Ala Phe Ile Phe 115 120 125 Ala Ile Thr Ser Ala Gly Val Thr
His Ser Val Ala Arg Ser Cys Ser 130 135 140 Glu Gly Ser Ile Glu Ser
Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 145 150 155 160 Gly Gly Pro
Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 165 170 175 Gly
Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 180 185
190 Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr
195 200 205 Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly
Met Ser 210 215 220 Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu
Pro Thr Leu Arg 225 230 235 240 Ala Val Gly Asp Val Leu Arg Asp Arg
Phe Asp Gly Ala Ser Arg Val 245 250 255 Leu Tyr Gly Asn Arg Gly Ser
Asn Arg Ala Ser Arg Ala Glu Leu Leu 260 265 270 Arg Leu Glu Pro Glu
Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 275 280 285 Leu Val Tyr
Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 290 295 300 Leu
Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 305 310
315 320 Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg
Thr 325 330 335 Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe
His Trp Cys 340 345 350 Cys His Val Ser Cys Arg Asn Cys Thr His Thr
Arg Val Leu His Glu 355 360 365 Cys Leu 370 <210> SEQ ID NO
101 <211> LENGTH: 648 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 101 Met Glu His Ile
Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 1 5 10 15 Phe Lys
Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 20 25 30
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 35
40 45 Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro
Asn 50 55 60 Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser
Leu His Asp 65 70 75 80 Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu
Gln Pro Glu Cys Cys 85 90 95 Ala Val Phe Arg Leu Leu His Glu His
Lys Gly Lys Lys Ala Arg Leu 100 105 110 Asp Trp Asn Thr Asp Ala Ala
Ser Leu Ile Gly Glu Glu Leu Gln Val 115 120 125 Asp Phe Leu Asp His
Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 130 135 140 Thr Phe Leu
Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 145 150 155 160
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 165
170 175 Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg
Gln 180 185 190 Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly
Val Pro Ala 195 200 205 Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu
Ser Val Ser Arg Met 210 215 220 Pro Val Ser Ser Gln His Arg Tyr Ser
Thr Pro His Ala Phe Thr Phe 225 230 235 240 Asn Thr Ser Ser Pro Ser
Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 245 250 255 Ser Thr Ser Thr
Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 260 265 270 Asp Ser
Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 275 280 285
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 290
295 300 Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala
Pro 305 310 315 320 Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro
Arg Gly Gln Arg 325 330 335 Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala
Ser Glu Val Met Leu Ser 340 345 350 Thr Arg Ile Gly Ser Gly Ser Phe
Gly Thr Val Tyr Lys Gly Lys Trp 355 360 365 His Gly Asp Val Ala Val
Lys Ile Leu Lys Val Val Asp Pro Thr Pro 370 375 380 Glu Gln Phe Gln
Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 385 390 395 400 Arg
His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 405 410
415 Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His
420 425 430 Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile
Asp Ile 435 440 445 Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His
Ala Lys Asn Ile 450 455 460 Ile His Arg Asp Met Lys Ser Asn Asn Ile
Phe Leu His Glu Gly Leu 465 470 475 480 Thr Val Lys Ile Gly Asp Phe
Gly Leu Ala Thr Val Lys Ser Arg Trp 485 490 495 Ser Gly Ser Gln Gln
Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 500 505 510 Ala Pro Glu
Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 515 520 525 Ser
Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 530 535
540 Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met
545 550 555 560 Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu
Tyr Lys Asn 565 570 575 Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp
Cys Val Lys Lys Val 580 585 590 Lys Glu Glu Arg Pro Leu Phe Pro Gln
Ile Leu Ser Ser Ile Glu Leu 595 600 605 Leu Gln His Ser Leu Pro Lys
Ile Asn Arg Ser Ala Ser Glu Pro Ser 610 615 620 Leu His Arg Ala Ala
His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 625 630 635 640 Thr Ser
Pro Arg Leu Pro Val Phe 645 <210> SEQ ID NO 102 <211>
LENGTH: 536 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 102 Met Gly Ser Asn Lys Ser Lys Pro
Lys Asp Ala Ser Gln Arg Arg Arg 1 5 10 15 Ser Leu Glu Pro Ala Glu
Asn Val His Gly Ala Gly Gly Gly Ala Phe 20 25 30 Pro Ala Ser Gln
Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 35 40 45
Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 50
55 60 Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala
Gly 65 70 75 80 Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr
Asp Tyr Glu 85 90 95 Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys
Gly Glu Arg Leu Gln 100 105 110 Ile Val Asn Asn Thr Glu Gly Asp Trp
Trp Leu Ala His Ser Leu Ser 115 120 125 Thr Gly Gln Thr Gly Tyr Ile
Pro Ser Asn Tyr Val Ala Pro Ser Asp 130 135 140 Ser Ile Gln Ala Glu
Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 145 150 155 160 Ser Glu
Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 165 170 175
Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 180
185 190 Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile
Arg 195 200 205 Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr
Gln Phe Asn 210 215 220 Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys
His Ala Asp Gly Leu 225 230 235 240 Cys His Arg Leu Thr Thr Val Cys
Pro Thr Ser Lys Pro Gln Thr Gln 245 250 255 Gly Leu Ala Lys Asp Ala
Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 260 265 270 Glu Val Lys Leu
Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 275 280 285 Trp Asn
Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 290 295 300
Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 305
310 315 320 Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu
Glu Pro 325 330 335 Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser
Leu Leu Asp Phe 340 345 350 Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg
Leu Pro Gln Leu Val Asp 355 360 365 Met Ala Ala Gln Ile Ala Ser Gly
Met Ala Tyr Val Glu Arg Met Asn 370 375 380 Tyr Val His Arg Asp Leu
Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 385 390 395 400 Leu Val Cys
Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 405 410 415 Asn
Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 420 425
430 Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val
435 440 445 Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly
Arg Val 450 455 460 Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp
Gln Val Glu Arg 465 470 475 480 Gly Tyr Arg Met Pro Cys Pro Pro Glu
Cys Pro Glu Ser Leu His Asp 485 490 495 Leu Met Cys Gln Cys Trp Arg
Lys Glu Pro Glu Glu Arg Pro Thr Phe 500 505 510 Glu Tyr Leu Gln Ala
Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 515 520 525 Gln Tyr Gln
Pro Gly Glu Asn Leu 530 535 <210> SEQ ID NO 103 <211>
LENGTH: 480 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 103 Met Ser Asp Val Ala Ile Val Lys
Glu Gly Trp Leu His Lys Arg Gly 1 5 10 15 Glu Tyr Ile Lys Thr Trp
Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 20 25 30 Gly Thr Phe Ile
Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 35 40 45 Glu Ala
Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 50 55 60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 65
70 75 80 Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu
Glu Arg 85 90 95 Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp
Gly Leu Lys Lys 100 105 110 Gln Glu Glu Glu Glu Met Asp Phe Arg Ser
Gly Ser Pro Ser Asp Asn 115 120 125 Ser Gly Ala Glu Glu Met Glu Val
Ser Leu Ala Lys Pro Lys His Arg 130 135 140 Val Thr Met Asn Glu Phe
Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 145 150 155 160 Phe Gly Lys
Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 165 170 175 Ala
Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 180 185
190 Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro
195 200 205 Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg
Leu Cys 210 215 220 Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe
Phe His Leu Ser 225 230 235 240 Arg Glu Arg Val Phe Ser Glu Asp Arg
Ala Arg Phe Tyr Gly Ala Glu 245 250 255 Ile Val Ser Ala Leu Asp Tyr
Leu His Ser Glu Lys Asn Val Val Tyr 260 265 270 Arg Asp Leu Lys Leu
Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 275 280 285 Lys Ile Thr
Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 290 295 300 Thr
Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 305 310
315 320 Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu
Gly 325 330 335 Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe
Tyr Asn Gln 340 345 350 Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met
Glu Glu Ile Arg Phe 355 360 365 Pro Arg Thr Leu Gly Pro Glu Ala Lys
Ser Leu Leu Ser Gly Leu Leu 370 375 380 Lys Lys Asp Pro Lys Gln Arg
Leu Gly Gly Gly Ser Glu Asp Ala Lys 385 390 395 400 Glu Ile Met Gln
His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 405 410 415 Tyr Glu
Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 420 425 430
Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 435
440 445 Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser
Glu 450 455 460 Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser
Gly Thr Ala 465 470 475 480 <210> SEQ ID NO 104 <211>
LENGTH: 379 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 104 Met Ala Ala Ala Ala Ala Gln Gly
Gly Gly Gly Gly Glu Pro Arg Arg 1 5 10 15 Thr Glu Gly Val Gly Pro
Gly Val Pro Gly Glu Val Glu Met Val Lys 20 25 30 Gly Gln Pro Phe
Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 35 40 45 Gly Glu
Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 50 55 60
Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 65
70 75 80 Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg
Phe Arg 85 90 95 His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg
Ala Ser Thr Leu 100 105 110 Glu Ala Met Arg Asp Val Tyr Ile Val Gln
Asp Leu Met Glu Thr Asp 115 120 125 Leu Tyr Lys Leu Leu Lys Ser Gln
Gln Leu Ser Asn Asp His Ile Cys 130 135 140 Tyr Phe Leu Tyr Gln Ile
Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 145 150 155 160 Asn Val Leu
His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 165 170 175 Thr
Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 180 185
190 Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg
195 200 205 Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr
Thr Lys 210 215 220 Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala
Glu Met Leu Ser 225 230 235 240 Asn Arg Pro Ile Phe Pro Gly Lys His
Tyr Leu Asp Gln Leu Asn His 245 250 255 Ile Leu Gly Ile Leu Gly Ser
Pro Ser Gln Glu Asp Leu Asn Cys Ile 260 265 270
Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 275
280 285 Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala
Leu 290 295 300 Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys
Arg Ile Thr 305 310 315 320 Val Glu Glu Ala Leu Ala His Pro Tyr Leu
Glu Gln Tyr Tyr Asp Pro 325 330 335 Thr Asp Glu Pro Val Ala Glu Glu
Pro Phe Thr Phe Ala Met Glu Leu 340 345 350 Asp Asp Leu Pro Lys Glu
Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 355 360 365 Ala Arg Phe Gln
Pro Gly Val Leu Glu Ala Pro 370 375 <210> SEQ ID NO 105
<211> LENGTH: 360 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 105 Met Ala Ala Ala Ala Ala Ala
Gly Ala Gly Pro Glu Met Val Arg Gly 1 5 10 15 Gln Val Phe Asp Val
Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 20 25 30 Glu Gly Ala
Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 35 40 45 Val
Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 50 55
60 Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His
65 70 75 80 Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr
Ile Glu 85 90 95 Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met
Glu Thr Asp Leu 100 105 110 Tyr Lys Leu Leu Lys Thr Gln His Leu Ser
Asn Asp His Ile Cys Tyr 115 120 125 Phe Leu Tyr Gln Ile Leu Arg Gly
Leu Lys Tyr Ile His Ser Ala Asn 130 135 140 Val Leu His Arg Asp Leu
Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 145 150 155 160 Cys Asp Leu
Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 165 170 175 Asp
His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 180 185
190 Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser
195 200 205 Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu
Ser Asn 210 215 220 Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln
Leu Asn His Ile 225 230 235 240 Leu Gly Ile Leu Gly Ser Pro Ser Gln
Glu Asp Leu Asn Cys Ile Ile 245 250 255 Asn Leu Lys Ala Arg Asn Tyr
Leu Leu Ser Leu Pro His Lys Asn Lys 260 265 270 Val Pro Trp Asn Arg
Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 275 280 285 Leu Leu Asp
Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 290 295 300 Glu
Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 305 310
315 320 Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu
Asp 325 330 335 Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu
Glu Thr Ala 340 345 350 Arg Phe Gln Pro Gly Tyr Arg Ser 355 360
<210> SEQ ID NO 106 <211> LENGTH: 239 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 106
Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 1 5
10 15 Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp
Ala 20 25 30 Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala
Pro Gly Ile 35 40 45 Phe Ser Ser Gln Pro Gly His Thr Pro His Pro
Ala Ala Ser Arg Asp 50 55 60 Pro Val Ala Arg Thr Ser Pro Leu Gln
Thr Pro Ala Ala Pro Gly Ala 65 70 75 80 Ala Ala Gly Pro Ala Leu Ser
Pro Val Pro Pro Val Val His Leu Thr 85 90 95 Leu Arg Gln Ala Gly
Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 100 105 110 Ala Glu Met
Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 115 120 125 Arg
Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 130 135
140 Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu
145 150 155 160 Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile
Ala Leu Trp 165 170 175 Met Thr Glu Tyr Leu Asn Arg His Leu His Thr
Trp Ile Gln Asp Asn 180 185 190 Gly Gly Trp Asp Ala Phe Val Glu Leu
Tyr Gly Pro Ser Met Arg Pro 195 200 205 Leu Phe Asp Phe Ser Trp Leu
Ser Leu Lys Thr Leu Leu Ser Leu Ala 210 215 220 Leu Val Gly Ala Cys
Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 225 230 235 <210> SEQ
ID NO 107 <211> LENGTH: 99 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 107 Met Thr Ser Lys
Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 1 5 10 15 Ala Ala
Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 20 25 30
Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 35
40 45 Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn
Thr 50 55 60 Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys
Leu Asp Pro 65 70 75 80 Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys
Phe Leu Lys Arg Ala 85 90 95 Glu Asn Ser <210> SEQ ID NO 108
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 108 Met Ala Arg Ala Ala Leu Ser
Ala Ala Pro Ser Asn Pro Arg Leu Leu 1 5 10 15 Arg Val Ala Leu Leu
Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 20 25 30 Ala Gly Ala
Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 35 40 45 Leu
Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 50 55
60 Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn
65 70 75 80 Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys
Lys Ile 85 90 95 Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 100
105 <210> SEQ ID NO 109 <211> LENGTH: 350 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
109 Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn
1 5 10 15 Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys
Met Leu 20 25 30 Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile
Ala Tyr Ala Leu 35 40 45 Val Phe Leu Leu Ser Leu Leu Gly Asn Ser
Leu Val Met Leu Val Ile 50 55 60 Leu Tyr Ser Arg Val Gly Arg Ser
Val Thr Asp Val Tyr Leu Leu Asn 65 70 75 80 Leu Ala Leu Ala Asp Leu
Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 85 90 95 Ala Ser Lys Val
Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 100 105 110 Val Ser
Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 115 120 125
Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 130
135 140 Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly
Cys 145 150 155 160 Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe
Leu Phe Arg Gln 165 170 175 Ala Tyr His Pro Asn Asn Ser Ser Pro Val
Cys Tyr Glu Val Leu Gly 180 185 190
Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 195
200 205 Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly
Phe 210 215 220 Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys
His Arg Ala 225 230 235 240 Met Arg Val Ile Phe Ala Val Val Leu Ile
Phe Leu Leu Cys Trp Leu 245 250 255 Pro Tyr Asn Leu Val Leu Leu Ala
Asp Thr Leu Met Arg Thr Gln Val 260 265 270 Ile Gln Glu Ser Cys Glu
Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 275 280 285 Ala Thr Glu Ile
Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 290 295 300 Tyr Ala
Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 305 310 315
320 Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val
325 330 335 Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu
340 345 350 <210> SEQ ID NO 110 <211> LENGTH: 360
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 110 Met Glu Asp Phe Asn Met Glu Ser Asp Ser
Phe Glu Asp Phe Trp Lys 1 5 10 15 Gly Glu Asp Leu Ser Asn Tyr Ser
Tyr Ser Ser Thr Leu Pro Pro Phe 20 25 30 Leu Leu Asp Ala Ala Pro
Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 35 40 45 Tyr Phe Val Val
Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 50 55 60 Gly Asn
Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 65 70 75 80
Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 85
90 95 Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly
Trp 100 105 110 Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu
Lys Glu Val 115 120 125 Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys
Ile Ser Val Asp Arg 130 135 140 Tyr Leu Ala Ile Val His Ala Thr Arg
Thr Leu Thr Gln Lys Arg Tyr 145 150 155 160 Leu Val Lys Phe Ile Cys
Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 165 170 175 Ala Leu Pro Val
Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 180 185 190 Ser Pro
Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 195 200 205
Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 210
215 220 Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe
Lys 225 230 235 240 Ala His Met Gly Gln Lys His Arg Ala Met Arg Val
Ile Phe Ala Val 245 250 255 Val Leu Ile Phe Leu Leu Cys Trp Leu Pro
Tyr Asn Leu Val Leu Leu 260 265 270 Ala Asp Thr Leu Met Arg Thr Gln
Val Ile Gln Glu Thr Cys Glu Arg 275 280 285 Arg Asn His Ile Asp Arg
Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 290 295 300 Leu His Ser Cys
Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 305 310 315 320 Phe
Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 325 330
335 Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser
340 345 350 Ser Gly His Thr Ser Thr Thr Leu 355 360
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