U.S. patent application number 13/690585 was filed with the patent office on 2013-04-04 for anti-pcsk9 antibodies with ph-dependent binding characteristics. This patent application is currently assigned to REGENERON PHARMACEUTICALS, INC.. The applicant listed for this patent is REGENERON PHARMACEUTICALS, INC.. Invention is credited to Tammy T. HUANG, Douglas MACDONALD, Joel H. MARTIN, Mark W. SLEEMAN.
Application Number | 20130085266 13/690585 |
Document ID | / |
Family ID | 41668268 |
Filed Date | 2013-04-04 |
United States Patent Application | 20130085266 |
Kind Code | A1 |
SLEEMAN; Mark W. ; et al. | April 4, 2013 |
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind human proprotein convertase subtilisin/kexin type 9 (hPCSK9) which do not exhibit enhanced binding affinity for hPCSK9 at acidic pH relative to neutral pH. In certain embodiments, the antibodies and antigen-binding fragments of the invention bind hPCSK9 with a lower affinity at acidic pH than at neutral pH.
Inventors: | SLEEMAN; Mark W.; (Melbourne, AU) ; MARTIN; Joel H.; (Putnam Valley, NY) ; HUANG; Tammy T.; (Goldens Bridge, NY) ; MACDONALD; Douglas; (New York, NY) | ||||||||||
Applicant: |
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Assignee: | REGENERON PHARMACEUTICALS,
INC. Tarrytown NY |
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Family ID: | 41668268 | ||||||||||
Appl. No.: | 13/690585 | ||||||||||
Filed: | November 30, 2012 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12949846 | Nov 19, 2010 | |||
13690585 | ||||
12637942 | Dec 15, 2009 | 8062640 | ||
12949846 | ||||
61122482 | Dec 15, 2008 | |||
61210566 | Mar 18, 2009 | |||
61168753 | Apr 13, 2009 | |||
61218136 | Jun 18, 2009 | |||
61249135 | Oct 6, 2009 | |||
61261776 | Nov 17, 2009 | |||
Current U.S. Class: | 530/387.9 ; 530/389.1 |
Current CPC Class: | A61K 2039/505 20130101; A61P 3/00 20180101; C07K 2317/76 20130101; A61P 3/04 20180101; C12N 15/09 20130101; A61P 13/12 20180101; A61P 1/16 20180101; A61K 2039/507 20130101; G01N 2333/33 20130101; Y10S 424/809 20130101; G01N 33/56911 20130101; C07K 2317/33 20130101; A61P 43/00 20180101; C07K 16/40 20130101; C07K 2317/565 20130101; A61P 9/00 20180101; A61P 9/10 20180101; C07K 16/1282 20130101; A61K 39/08 20130101; A61P 5/14 20180101; C07K 2317/21 20130101; C07K 2317/34 20130101; A61P 3/06 20180101; C07K 2317/56 20130101; C12Y 304/21061 20130101; C07K 2317/92 20130101; A61K 39/08 20130101; A61K 2300/00 20130101 |
Class at Publication: | 530/387.9 ; 530/389.1 |
International Class: | C07K 16/40 20060101 C07K016/40 |
Sequence CWU 1
1
7631351DNAArtificial SequenceSynthetic 1caggtccagc tggtgcagtc
tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag cctctggatt
tactctaagt agttacgaca tgcactgggt ccgccaatct 120acaggaaaag
gtctggagtg ggtctcagct attggttcta ccggtgacac atactatcca
180ggctccgtga agggccgatt caccatcacc agagaaaaag ccaagaactc
cgtgtatctt 240caaatgaaca gcctgagagc cggggacacg gctgtgtatt
actgtgtaag agaggggtgg 300gaggtaccct ttgactactg gggccaggga
accctggtca ctgtctcctc a 3512117PRTArtificial SequenceSynthetic 2Gln
Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10
15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr
20 25 30 Asp Met His Trp Val Arg Gln Ser Thr Gly Lys Gly Leu Glu
Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr Pro
Gly Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Thr Arg Glu Lys Ala
Lys Asn Ser Val Tyr Leu65 70 75 80 Gln Met Asn Ser Leu Arg Ala Gly
Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Glu Gly Trp Glu Val
Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser
Ser 115 324DNAArtificial SequenceSynthetic 3ggatttactc taagtagtta
cgac 2448PRTArtificial SequenceSynthetic 4Gly Phe Thr Leu Ser Ser
Tyr Asp1 5 521DNAArtificial SequenceSynthetic 5attggttcta
ccggtgacac a 2167PRTArtificial SequenceSynthetic 6Ile Gly Ser Thr
Gly Asp Thr1 5 733DNAArtificial SequenceSynthetic 7gtaagagagg
ggtgggaggt accctttgac tac 33811PRTArtificial SequenceSynthetic 8Val
Arg Glu Gly Trp Glu Val Pro Phe Asp Tyr1 5 10 9327DNAArtificial
SequenceSynthetic 9gacatccaga tgacccagtc tccagccacc ctgtctgtgt
ctccagggga aagagccgcc 60ctctcctgca gggccagtca gagtgttagc agcaacttag
cctggtacca ccagaaacct 120ggccaggctc ccaggctcct catctatggt
gcatccacca gggccactgg tatcccagcc 180aggttcagtg gcattgggtc
tgggacagag ttcactctca ttatcagcag cctgcagtct 240gaagattttg
cattttattt ctgtcagcag tataataact ggcctccatt cactttcggc
300cctgggacca aggtggagat caaacga 32710109PRTArtificial
SequenceSynthetic 10Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser
Val Ser Pro Gly1 5 10 15 Glu Arg Ala Ala Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr His Gln Lys Pro
Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ile Gly Ser Gly
Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln Ser65 70 75 80 Glu Asp
Phe Ala Phe Tyr Phe Cys Gln Gln Tyr Asn Asn Trp Pro Pro 85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105
1118DNAArtificial SequenceSynthetic 11cagagtgtta gcagcaac
18126PRTArtificial SequenceSynthetic 12Gln Ser Val Ser Ser Asn1 5
139DNAArtificial SequenceSynthetic 13ggtgcatcc 9143PRTArtificial
SequenceSynthetic 14Gly Ala Ser1 1530DNAArtificial
SequenceSynthetic 15cagcagtata ataactggcc tccattcact
301610PRTArtificial SequenceSynthetic 16Gln Gln Tyr Asn Asn Trp Pro
Pro Phe Thr1 5 10 17351DNAArtificial SequenceSynthetic 17gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt tactctaagt agttacgaca tgcactgggt ccgccaatct
120acaggaaaag gtctggagtg ggtctcagct attggttcta ccggtgacac
atactatcca 180ggctccgtga agggccgatt caccatcacc agagaaaaag
ccaagaactc cgtgtatctt 240caaatgaaca gcctgagagc cggggacacg
gctgtgtatt actgtgtaag agaggggtgg 300gaggtaccct ttgactactg
gggccaggga accctggtca ccgtctcctc a 35118117PRTArtificial
SequenceSynthetic 18Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ser
Thr Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr
Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe Thr
Ile Thr Arg Glu Lys Ala Lys Asn Ser Val Tyr Leu65 70 75 80 Gln Met
Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95
Arg Glu Gly Trp Glu Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100
105 110 Val Thr Val Ser Ser 115 19324DNAArtificial
SequenceSynthetic 19gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt
ctccagggga aagagccgcc 60ctctcctgca gggccagtca gagtgttagc agcaacttag
cctggtacca ccagaaacct 120ggccaggctc ccaggctcct catctatggt
gcatccacca gggccactgg tatcccagcc 180aggttcagtg gcattgggtc
tgggacagag ttcactctca ttatcagcag cctgcagtct 240gaagattttg
cattttattt ctgtcagcag tataataact ggcctccatt cactttcggc
300cctgggacca aagtggatat caaa 32420108PRTArtificial
SequenceSynthetic 20Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser
Val Ser Pro Gly1 5 10 15 Glu Arg Ala Ala Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr His Gln Lys Pro
Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ile Gly Ser Gly
Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln Ser65 70 75 80 Glu Asp
Phe Ala Phe Tyr Phe Cys Gln Gln Tyr Asn Asn Trp Pro Pro 85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105
21351DNAArtificial SequenceSynthetic 21gaggtgcagc tggtggagtc
tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag cctctggatt
tactctaagt agttacgaca tgcactgggt ccgccaagct 120acaggaaaag
gtctggagtg ggtctcagct attggttcta ccggtgacac atactatcca
180ggctccgtga agggccgatt caccatctcc agagaaaatg ccaagaactc
cttgtatctt 240caaatgaaca gcctgagagc cggggacacg gctgtgtatt
actgtgtaag agaggggtgg 300gaggtaccct ttgactactg gggccaggga
accctggtca ccgtctcctc a 35122117PRTArtificial SequenceSynthetic
22Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser
Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr
Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Glu Asn
Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln Met Asn Ser Leu Arg Ala
Gly Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Glu Gly Trp Glu
Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val
Ser Ser 115 23324DNAArtificial SequenceSynthetic 23gaaatagtga
tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60ctctcctgca
gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct
120ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg
tatcccagcc 180aggttcagtg gcagtgggtc tgggacagag ttcactctca
ccatcagcag cctgcagtct 240gaagattttg cagtttatta ctgtcagcag
tataataact ggcctccatt cactttcggc 300cctgggacca aagtggatat caaa
32424108PRTArtificial SequenceSynthetic 24Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn
Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
Lys 100 105 25342DNAArtificial SequenceSynthetic 25caggtgcagc
tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag
cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct
120ccaggcaagg ggctggagtg ggtggcgttt ataggatttg atggaagtaa
tatacattat 180ggagactccg tgaggggccg aatcatcata tccagagaca
attccgagaa cacgttgtat 240ctggaaatga acagcctgag agccgaggac
acggcaatgt actattgtgc gagagagaag 300ggtttagact ggggccaggg
aaccacggtc accgtctcct ca 34226114PRTArtificial SequenceSynthetic
26Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ala Phe Ile Gly Phe Asp Gly Ser Asn Ile His
Tyr Gly Asp Ser Val 50 55 60 Arg Gly Arg Ile Ile Ile Ser Arg Asp
Asn Ser Glu Asn Thr Leu Tyr65 70 75 80 Leu Glu Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly
Leu Asp Trp Gly Gln Gly Thr Thr Val Thr Val 100 105 110 Ser
Ser2724DNAArtificial SequenceSynthetic 27ggattcacct tcagtagcta tggc
24288PRTArtificial SequenceSynthetic 28Gly Phe Thr Phe Ser Ser Tyr
Gly1 5 2924DNAArtificial SequenceSynthetic 29ataggatttg atggaagtaa
tata 24308PRTArtificial SequenceSynthetic 30Ile Gly Phe Asp Gly Ser
Asn Ile1 5 3121DNAArtificial SequenceSynthetic 31gcgagagaga
agggtttaga c 21327PRTArtificial SequenceSynthetic 32Ala Arg Glu Lys
Gly Leu Asp1 5 33321DNAArtificial SequenceSynthetic 33gccatccaga
tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca
120gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
ccatcagcag cctgcagcct 240gatgattttg caacttatta ctgccaacag
tataatagtt attacacttt tggccagggg 300accaaggtgg aaatcaaacg a
32134107PRTArtificial SequenceSynthetic 34Ala Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser
Tyr Tyr Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105 3518DNAArtificial SequenceSynthetic 35cagagtatta gtagctgg
18366PRTArtificial SequenceSynthetic 36Gln Ser Ile Ser Ser Trp1 5
379DNAArtificial SequenceSynthetic 37aaggcgtct 9383PRTArtificial
SequenceSynthetic 38Lys Ala Ser1 3924DNAArtificial
SequenceSynthetic 39caacagtata atagttatta cact 24408PRTArtificial
SequenceSynthetic 40Gln Gln Tyr Asn Ser Tyr Tyr Thr1 5
41342DNAArtificial SequenceSynthetic 41caggtgcagc tggtggagtc
tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag cgtctggatt
caccttcagt agctatggca tgcactgggt ccgccaggct 120ccaggcaagg
ggctggagtg ggtggcgttt ataggatttg atggaagtaa tatacattat
180ggagactccg tgaggggccg aatcatcata tccagagaca attccgagaa
cacgttgtat 240ctggaaatga acagcctgag agccgaggac acggcaatgt
actattgtgc gagagagaag 300ggtttagact ggggccaggg aaccctggtc
accgtctcct ca 34242114PRTArtificial SequenceSynthetic 42Gln Val Gln
Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Phe Ile Gly Phe Asp Gly Ser Asn Ile His Tyr Gly Asp
Ser Val 50 55 60 Arg Gly Arg Ile Ile Ile Ser Arg Asp Asn Ser Glu
Asn Thr Leu Tyr65 70 75 80 Leu Glu Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Leu Asp Trp
Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser
Ser43318DNAArtificial SequenceSynthetic 43gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tataatagtt
attacacttt tggccagggg 300accaagctgg agatcaaa 31844106PRTArtificial
SequenceSynthetic 44Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser
Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly
Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80 Asp Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Tyr Thr 85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 45342DNAArtificial
SequenceSynthetic 45caggtgcagc tggtggagtc tgggggaggc gtggtccagc
ctgggaggtc cctgagactc 60tcctgtgcag cctctggatt caccttcagt agctatggca
tgcactgggt ccgccaggct 120ccaggcaagg ggctggagtg ggtggcagtt
ataggatttg atggaagtaa tatatactat 180gcagactccg tgaagggccg
attcaccatc tccagagaca attccaagaa cacgctgtat 240ctgcaaatga
acagcctgag agctgaggac acggctgtgt attactgtgc gagagagaag
300ggtttagact ggggccaggg aaccctggtc accgtctcct ca
34246114PRTArtificial SequenceSynthetic 46Gln Val Gln Leu Val Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Val Ile Gly Phe Asp Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Leu Asp Trp Gly Gln Gly
Thr Leu Val Thr Val 100 105 110 Ser Ser47319DNAArtificial
SequenceSynthetic 47gacatccaga tgacccagtc tccttccacc ctgtctgcat
ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca gagtattagt agctggttgg
cctggtatca gcagaaacca 120gggaaagccc ctaagctcct
gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180aggttcagcg
gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct
240gatgattttg caacttatta ctgccaacag tataatagtt attacacttt
tggccagggg 300accaagctgg agatcaaac 31948106PRTArtificial
SequenceSynthetic 48Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser
Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly
Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80 Asp Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Tyr Thr 85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 49342DNAArtificial
SequenceSynthetic 49caggtgcagc tgcaggagtc tgggggaggc gtggtccagc
ctgggaggtc cctgagactc 60tcctgtgcag cgtctggatt caccttcagt agctatggca
tgcactgggt ccgccaggct 120ccaggcaagg ggctggagtg ggtggcgttt
ataggatttg atggaagtaa tatatattat 180ggagactccg tgaggggccg
aatcatcata tccagagaca attccgagaa cacgttgtat 240ctggaaatga
acagcctgag agccgaggac acggcagtgt attattgtgc gagagagaag
300ggtttagact ggggccaggg aaccctggtc actgtctcct ca
34250114PRTArtificial SequenceSynthetic 50Gln Val Gln Leu Gln Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Phe Ile Gly Phe Asp Gly Ser Asn Ile Tyr Tyr Gly Asp Ser Val 50
55 60 Arg Gly Arg Ile Ile Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu
Tyr65 70 75 80 Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Leu Asp Trp Gly Gln Gly
Thr Leu Val Thr Val 100 105 110 Ser Ser5124DNAArtificial
SequenceSynthetic 51ggattcacct tcagtagcta tggc 24528PRTArtificial
SequenceSynthetic 52Gly Phe Thr Phe Ser Ser Tyr Gly1 5
5324DNAArtificial SequenceSynthetic 53ataggatttg atggaagtaa tata
24548PRTArtificial SequenceSynthetic 54Ile Gly Phe Asp Gly Ser Asn
Ile1 5 5521DNAArtificial SequenceSynthetic 55gcgagagaga agggtttaga
c 21567PRTArtificial SequenceSynthetic 56Ala Arg Glu Lys Gly Leu
Asp1 5 57342DNAArtificial SequenceSynthetic 57gccatccaga tgacccagtc
tccagactcc ctggctgtgt ctctgggcga gagggccacc 60atcaactgca agtccagcca
gagtgttttt cacacctcca acaataagaa ctacttagtt 120tggtatcagc
agaaaccagg acagcctcct aagttgctcc tttactgggc ctctacccgg
180gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt
cactctcacc 240atcagcagcc tgcaggctga agatgtggca aattattact
gtcaccaata ttacagtatt 300ccgtggacgt tcggccaagg gaccaaggtg
gagatcaaac ga 34258114PRTArtificial SequenceSynthetic 58Ala Ile Gln
Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly1 5 10 15 Glu
Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe His Thr 20 25
30 Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45 Pro Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser
Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala
Asn Tyr Tyr Cys His Gln 85 90 95 Tyr Tyr Ser Ile Pro Trp Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys
Arg5936DNAArtificial SequenceSynthetic 59cagagtgttt ttcacacctc
caacaataag aactac 366012PRTArtificial SequenceSynthetic 60Gln Ser
Val Phe His Thr Ser Asn Asn Lys Asn Tyr1 5 10 619DNAArtificial
SequenceSynthetic 61tgggcctct 9623PRTArtificial SequenceSynthetic
62Trp Ala Ser1 6327DNAArtificial SequenceSynthetic 63caccaatatt
acagtattcc gtggacg 27649PRTArtificial SequenceSynthetic 64His Gln
Tyr Tyr Ser Ile Pro Trp Thr1 5 65342DNAArtificial SequenceSynthetic
65caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc
60tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct
120ccaggcaagg ggctggagtg ggtggcgttt ataggatttg atggaagtaa
tatatattat 180ggagactccg tgaggggccg aatcatcata tccagagaca
attccgagaa cacgttgtat 240ctggaaatga acagcctgag agccgaggac
acggcagtgt attattgtgc gagagagaag 300ggtttagact ggggccaggg
aaccctggtc accgtctcct ca 34266114PRTArtificial SequenceSynthetic
66Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser
Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ala Phe Ile Gly Phe Asp Gly Ser Asn Ile Tyr
Tyr Gly Asp Ser Val 50 55 60 Arg Gly Arg Ile Ile Ile Ser Arg Asp
Asn Ser Glu Asn Thr Leu Tyr65 70 75 80 Leu Glu Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly
Leu Asp Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser
Ser67339DNAArtificial SequenceSynthetic 67gacatcgtga tgacccagtc
tccagactcc ctggctgtgt ctctgggcga gagggccacc 60atcaactgca agtccagcca
gagtgttttt cacacctcca acaataagaa ctacttagtt 120tggtatcagc
agaaaccagg acagcctcct aagttgctcc tttactgggc ctctacccgg
180gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt
cactctcacc 240atcagcagcc tgcaggctga agatgtggca aattattact
gtcaccaata ttacagtatt 300ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaa
33968113PRTArtificial SequenceSynthetic 68Asp Ile Val Met Thr Gln
Ser Pro Asp Ser Leu Ala Val Ser Leu Gly1 5 10 15 Glu Arg Ala Thr
Ile Asn Cys Lys Ser Ser Gln Ser Val Phe His Thr 20 25 30 Ser Asn
Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45
Pro Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50
55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Asn Tyr Tyr
Cys His Gln 85 90 95 Tyr Tyr Ser Ile Pro Trp Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile 100 105 110 Lys69342DNAArtificial
SequenceSynthetic 69caggtgcagc tggtggagtc tgggggaggc gtggtccagc
ctgggaggtc cctgagactc 60tcctgtgcag cctctggatt caccttcagt agctatggca
tgcactgggt ccgccaggct 120ccaggcaagg ggctggagtg ggtggcagtt
ataggatttg atggaagtaa tatatactat 180gcagactccg tgaagggccg
attcaccatc tccagagaca attccaagaa cacgctgtat 240ctgcaaatga
acagcctgag agctgaggac acggctgtgt attactgtgc gagagagaag
300ggtttagact ggggccaggg aaccctggtc accgtctcct ca
34270114PRTArtificial SequenceSynthetic 70Gln Val Gln Leu Val Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Val Ile Gly Phe Asp Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Leu Asp Trp Gly Gln Gly
Thr Leu Val Thr Val 100 105 110 Ser Ser71339DNAArtificial
SequenceSynthetic 71gacatcgtga tgacccagtc tccagactcc ctggctgtgt
ctctgggcga gagggccacc 60atcaactgca agtccagcca gagtgttttt cacacctcca
acaataagaa ctacttagct 120tggtaccagc agaaaccagg acagcctcct
aagctgctca tttactgggc ctctacccgg 180gaatccgggg tccctgaccg
attcagtggc agcgggtctg ggacagattt cactctcacc 240atcagcagcc
tgcaggctga agatgtggca gtttattact gtcaccaata ttacagtatt
300ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaa 33972113PRTArtificial
SequenceSynthetic 72Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala
Val Ser Leu Gly1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
Gln Ser Val Phe His Thr 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile
Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr65 70 75 80 Ile Ser
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 85 90 95
Tyr Tyr Ser Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100
105 110 Lys73354DNAArtificial SequenceSynthetic 73gaagtgcagc
tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacctttaac aactatgcca tgaactgggt ccgccaggct
120ccaggaaagg gactggactg ggtctcaact attagtggta gcggtggtac
tacaaactac 180gcagactccg tgaagggccg tttcattatt tcccgagaca
gttccaaaca cacgctgtat 240ctgcaaatga acagcctgag agccgaggac
acggccgtat attactgtgc gaaagattct 300aactggggaa atttcgatct
ctggggccgt ggcaccacgg tcactgtctc ctca 35474118PRTArtificial
SequenceSynthetic 74Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val
Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Thr Phe Asn Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ser Thr Ile Ser Gly Ser
Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe
Ile Ile Ser Arg Asp Ser Ser Lys His Thr Leu Tyr65 70 75 80 Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Ser Asn Trp Gly Asn Phe Asp Leu Trp Gly Arg Gly Thr 100
105 110 Thr Val Thr Val Ser Ser 115 7524DNAArtificial
SequenceSynthetic 75ggattcacct ttaacaacta tgcc 24768PRTArtificial
SequenceSynthetic 76Gly Phe Thr Phe Asn Asn Tyr Ala1 5
7724DNAArtificial SequenceSynthetic 77attagtggta gcggtggtac taca
24788PRTArtificial SequenceSynthetic 78Ile Ser Gly Ser Gly Gly Thr
Thr1 5 7933DNAArtificial SequenceSynthetic 79gcgaaagatt ctaactgggg
aaatttcgat ctc 338011PRTArtificial SequenceSynthetic 80Ala Lys Asp
Ser Asn Trp Gly Asn Phe Asp Leu1 5 10 81342DNAArtificial
SequenceSynthetic 81gacatccaga tgacccagtc tccagactcc ctggctgtgt
ctctgggcga gagggccacc 60atcaactgca agtccagcca gagtgtttta tacaggtcca
acaataggaa cttcttaggt 120tggtaccagc agaaaccagg gcagcctcct
aatctactca tttactgggc atctacccgg 180gaatccgggg tccctgaccg
attcagtggc agcgggtctg ggacagattt cactctcacc 240atcagcagcc
tgcaggctga agatgtggca gtttattact gtcaacaata ttatactact
300ccgtacactt ttggccaggg gaccaaggtg gaaatcaaac ga
34282114PRTArtificial SequenceSynthetic 82Asp Ile Gln Met Thr Gln
Ser Pro Asp Ser Leu Ala Val Ser Leu Gly1 5 10 15 Glu Arg Ala Thr
Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 20 25 30 Ser Asn
Asn Arg Asn Phe Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45
Pro Pro Asn Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50
55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr
Cys Gln Gln 85 90 95 Tyr Tyr Thr Thr Pro Tyr Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile 100 105 110 Lys Arg8336DNAArtificial
SequenceSynthetic 83cagagtgttt tatacaggtc caacaatagg aacttc
368412PRTArtificial SequenceSynthetic 84Gln Ser Val Leu Tyr Arg Ser
Asn Asn Arg Asn Phe1 5 10 859DNAArtificial SequenceSynthetic
85tgggcatct 9863PRTArtificial SequenceSynthetic 86Trp Ala Ser1
8727DNAArtificial SequenceSynthetic 87caacaatatt atactactcc gtacact
27889PRTArtificial SequenceSynthetic 88Gln Gln Tyr Tyr Thr Thr Pro
Tyr Thr1 5 89354DNAArtificial SequenceSynthetic 89gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacctttaac aactatgcca tgaactgggt ccgccaggct
120ccaggaaagg gactggactg ggtctcaact attagtggta gcggtggtac
tacaaactac 180gcagactccg tgaagggccg tttcattatt tcccgagaca
gttccaaaca cacgctgtat 240ctgcaaatga acagcctgag agccgaggac
acggccgtat attactgtgc gaaagattct 300aactggggaa atttcgatct
ctggggccgt ggcaccctgg tcactgtctc ctca 35490118PRTArtificial
SequenceSynthetic 90Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Thr Phe Asn Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ser Thr Ile Ser Gly Ser
Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe
Ile Ile Ser Arg Asp Ser Ser Lys His Thr Leu Tyr65 70 75 80 Leu Gln
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95
Ala Lys Asp Ser Asn Trp Gly Asn Phe Asp Leu Trp Gly Arg Gly Thr 100
105 110 Leu Val Thr Val Ser Ser 115 91339DNAArtificial
SequenceSynthetic 91gacatcgtga tgacccagtc tccagactcc ctggctgtgt
ctctgggcga gagggccacc 60atcaactgca agtccagcca gagtgtttta tacaggtcca
acaataggaa cttcttaggt 120tggtaccagc agaaaccagg gcagcctcct
aatctactca tttactgggc atctacccgg 180gaatccgggg tccctgaccg
attcagtggc agcgggtctg ggacagattt cactctcacc 240atcagcagcc
tgcaggctga agatgtggca gtttattact gtcaacaata ttatactact
300ccgtacactt ttggccaggg gaccaagctg gagatcaaa 33992113PRTArtificial
SequenceSynthetic 92Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala
Val Ser Leu Gly1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
Gln Ser Val Leu Tyr Arg 20 25 30 Ser Asn Asn Arg Asn Phe Leu Gly
Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Asn Leu Leu Ile
Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr65 70 75 80 Ile Ser
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95
Tyr Tyr Thr Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 100
105 110 Lys93354DNAArtificial SequenceSynthetic 93gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacctttaac aactatgcca tgagctgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcagct attagtggta gcggtggtac
tacatactac
180gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa
cacgctgtat 240ctgcaaatga acagcctgag agccgaggac acggccgtat
attactgtgc gaaagattct 300aactggggaa atttcgatct ctggggccgt
ggcaccctgg tcactgtctc ctca 35494118PRTArtificial SequenceSynthetic
94Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn
Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr
Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Ser Asn
Trp Gly Asn Phe Asp Leu Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr
Val Ser Ser 115 95339DNAArtificial SequenceSynthetic 95gacatcgtga
tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60atcaactgca
agtccagcca gagtgtttta tacaggtcca acaataggaa cttcttagct
120tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc
atctacccgg 180gaatccgggg tccctgaccg attcagtggc agcgggtctg
ggacagattt cactctcacc 240atcagcagcc tgcaggctga agatgtggca
gtttattact gtcaacaata ttatactact 300ccgtacactt ttggccaggg
gaccaagctg gagatcaaa 33996113PRTArtificial SequenceSynthetic 96Asp
Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly1 5 10
15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg
20 25 30 Ser Asn Asn Arg Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp
Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Thr Thr Pro Tyr
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 100 105 110
Lys97351DNAArtificial SequenceSynthetic 97caggtgcagc tggtgcagtc
tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag tctctggatt
caccctcagt agctacgata tgcactgggt ccgccaacct 120acaggaaaag
gtctggagtg ggtctcagct attggttcta ctggtgacac atactatcca
180ggctccgtga agggccgatt caccatctcc agagaaaatg ccaagaactc
cttgtatctt 240caaatgaaca gcctgagagc cggggacacg gctgtgtatt
actgtgcaag agagggatgg 300gacgtaccct ttgacttctg gggccaggga
accctggtca ccgtctcctc a 35198117PRTArtificial SequenceSynthetic
98Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Ser Ser
Tyr 20 25 30 Asp Met His Trp Val Arg Gln Pro Thr Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr
Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Glu Asn
Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln Met Asn Ser Leu Arg Ala
Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Trp Asp
Val Pro Phe Asp Phe Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val
Ser Ser 115 9924DNAArtificial SequenceSynthetic 99ggattcaccc
tcagtagcta cgat 241008PRTArtificial SequenceSynthetic 100Gly Phe
Thr Leu Ser Ser Tyr Asp1 5 10121DNAArtificial SequenceSynthetic
101attggttcta ctggtgacac a 211027PRTArtificial SequenceSynthetic
102Ile Gly Ser Thr Gly Asp Thr1 5 10333DNAArtificial
SequenceSynthetic 103gcaagagagg gatgggacgt accctttgac ttc
3310411PRTArtificial SequenceSynthetic 104Ala Arg Glu Gly Trp Asp
Val Pro Phe Asp Phe1 5 10 105324DNAArtificial SequenceSynthetic
105gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga
cagagtcacc 60atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca
gcagaaacca 120gggaaagccc ctaagctcct gatctatgct gcatccagtt
tacaaagtgg ggtcccatca 180cggttcagcg gcagtggatc tggcacagat
ttcactctca ccatcagcag cctgcagcct 240gaagattttg caacttatta
ctgtctacaa gattacaatt acccgtggac gttcggccaa 300gggaccaagg
tggagatcaa acga 324106108PRTArtificial SequenceSynthetic 106Ala Ile
Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20
25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
Gln Asp Tyr Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys Arg 100 105 10718DNAArtificial SequenceSynthetic
107caggacatta gaaatgat 181086PRTArtificial SequenceSynthetic 108Gln
Asp Ile Arg Asn Asp1 5 1099DNAArtificial SequenceSynthetic
109gctgcatcc 91103PRTArtificial SequenceSynthetic 110Ala Ala Ser1
11127DNAArtificial SequenceSynthetic 111ctacaagatt acaattaccc
gtggacg 271129PRTArtificial SequenceSynthetic 112Leu Gln Asp Tyr
Asn Tyr Pro Trp Thr1 5 113351DNAArtificial SequenceSynthetic
113gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc
cctgagactc 60tcctgtgcag tctctggatt caccctcagt agctacgata tgcactgggt
ccgccaacct 120acaggaaaag gtctggagtg ggtctcagct attggttcta
ctggtgacac atactatcca 180ggctccgtga agggccgatt caccatctcc
agagaaaatg ccaagaactc cttgtatctt 240caaatgaaca gcctgagagc
cggggacacg gctgtgtatt actgtgcaag agagggatgg 300gacgtaccct
ttgacttctg gggccaggga accctggtca ccgtctcctc a
351114117PRTArtificial SequenceSynthetic 114Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Val Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met
His Trp Val Arg Gln Pro Thr Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50
55 60 Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr
Leu65 70 75 80 Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr
Tyr Cys Ala 85 90 95 Arg Glu Gly Trp Asp Val Pro Phe Asp Phe Trp
Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
115321DNAArtificial SequenceSynthetic 115gccatccaga tgacccagtc
tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggcaagtca
ggacattaga aatgatttag gctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca
180cggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag
cctgcagcct 240gaagattttg caacttatta ctgtctacaa gattacaatt
acccgtggac gttcggccaa 300gggaccaagg tggaaatcaa a
321116107PRTArtificial SequenceSynthetic 116Ala Ile Gln Met Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn
Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 117351DNAArtificial SequenceSynthetic 117gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccctcagt agctacgata tgcactgggt ccgccaagct
120acaggaaaag gtctggagtg ggtctcagct attggttcta ctggtgacac
atactatcca 180ggctccgtga agggccgatt caccatctcc agagaaaatg
ccaagaactc cttgtatctt 240caaatgaaca gcctgagagc cggggacacg
gctgtgtatt actgtgcaag agagggatgg 300gacgtaccct ttgacttctg
gggccaggga accctggtca ccgtctcctc a 351118117PRTArtificial
SequenceSynthetic 118Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln
Ala Thr Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser
Thr Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe
Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln
Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Gly Trp Asp Val Pro Phe Asp Phe Trp Gly Gln Gly Thr Leu
100 105 110 Val Thr Val Ser Ser 115 119321DNAArtificial
SequenceSynthetic 119gccatccaga tgacccagtc tccatcctcc ctgtctgcat
ctgtaggaga cagagtcacc 60atcacttgcc gggcaagtca ggacattaga aatgatttag
gctggtatca gcagaaacca 120gggaaagccc ctaagctcct gatctatgct
gcatccagtt tacaaagtgg ggtcccatca 180aggttcagcg gcagtggatc
tggcacagat ttcactctca ccatcagcag cctgcagcct 240gaagattttg
caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa
300gggaccaagg tggaaatcaa a 321120107PRTArtificial SequenceSynthetic
120Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1
5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn
Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys 100 105 121384DNAArtificial
SequenceSynthetic 121caggtgcagc tgcaggagtc ggggccagga ctggtgaagc
cttcggagac cctgtccctc 60acctgcactg tctctgggga ctccatcaat acttactact
ggagctggtt ccggcagccc 120ccagggaagg gactggagtg gattgggtat
atctattata gtggaaccac caactacaac 180ccctccctca agagtcgagt
caccatatca atagacacgc ccaggaacca gttctccctg 240aagctgatct
ctgtgaccgc agcggacacg gccgtgtatt actgtgcgag agagaggatt
300actatgattc ggggagttac cctctactat tactcctacg gtatggacgt
ctggggccaa 360gggaccacgg tcaccgtctc ctca 384122128PRTArtificial
SequenceSynthetic 122Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
Val Lys Pro Ser Glu1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser
Gly Asp Ser Ile Asn Thr Tyr 20 25 30 Tyr Trp Ser Trp Phe Arg Gln
Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr
Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val
Thr Ile Ser Ile Asp Thr Pro Arg Asn Gln Phe Ser Leu65 70 75 80 Lys
Leu Ile Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Arg Ile Thr Met Ile Arg Gly Val Thr Leu Tyr Tyr Tyr Ser
100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser 115 120 125 12324DNAArtificial SequenceSynthetic
123ggggactcca tcaatactta ctac 241248PRTArtificial SequenceSynthetic
124Gly Asp Ser Ile Asn Thr Tyr Tyr1 5 12521DNAArtificial
SequenceSynthetic 125atctattata gtggaaccac c 211267PRTArtificial
SequenceSynthetic 126Ile Tyr Tyr Ser Gly Thr Thr1 5
12766DNAArtificial SequenceSynthetic 127gcgagagaga ggattactat
gattcgggga gttaccctct actattactc ctacggtatg 60gacgtc
6612822PRTArtificial SequenceSynthetic 128Ala Arg Glu Arg Ile Thr
Met Ile Arg Gly Val Thr Leu Tyr Tyr Tyr1 5 10 15 Ser Tyr Gly Met
Asp Val 20 129324DNAArtificial SequenceSynthetic 129gacatccaga
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgct
gggccagtca ggacattagc agttatttag cctggtatca gcaaaaacca
120gggatagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg
ggtcccatca 180aggttcggcg gcagtggatc tgggacagaa ttcactctca
caatcagcag cctgcagcct 240gaagattttg caacttatta ctgtcaacag
cttaatagtt accctcggac gttcggccaa 300gggaccaagg tggaaatcaa acga
324130108PRTArtificial SequenceSynthetic 130Asp Ile Gln Met Thr Gln
Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Trp Ala Ser Gln Asp Ile Ser Ser Tyr 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser
Tyr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
Arg 100 105 13118DNAArtificial SequenceSynthetic 131caggacatta
gcagttat 181326PRTArtificial SequenceSynthetic 132Gln Asp Ile Ser
Ser Tyr1 5 1339DNAArtificial SequenceSynthetic 133gctgcatcc
91343PRTArtificial SequenceSynthetic 134Ala Ala Ser1
13527DNAArtificial SequenceSynthetic 135caacagctta atagttaccc
tcggacg 271369PRTArtificial SequenceSynthetic 136Gln Gln Leu Asn
Ser Tyr Pro Arg Thr1 5 137384DNAArtificial SequenceSynthetic
137caggtgcagc tgcaggagtc ggggccagga ctggtgaagc cttcggagac
cctgtccctc 60acctgcactg tctctgggga ctccatcaat acttactact ggagctggtt
ccggcagccc 120ccagggaagg gactggagtg gattgggtat atctattata
gtggaaccac caactacaac 180ccctccctca agagtcgagt caccatatca
atagacacgc ccaggaacca gttctccctg 240aagctgatct ctgtgaccgc
agcggacacg gccgtgtatt actgtgcgag agagaggatt 300actatgattc
ggggagttac cctctactat tactcctacg gtatggacgt ctggggccaa
360gggaccacgg tcaccgtctc ctca 384138128PRTArtificial
SequenceSynthetic 138Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
Val Lys Pro Ser Glu1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser
Gly Asp Ser Ile Asn Thr Tyr 20 25 30 Tyr Trp Ser Trp Phe Arg Gln
Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr
Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val
Thr Ile Ser Ile Asp Thr Pro Arg Asn Gln Phe Ser Leu65 70 75 80 Lys
Leu Ile Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Arg Ile Thr Met Ile Arg Gly Val Thr Leu Tyr Tyr Tyr
Ser
100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser 115 120 125 139321DNAArtificial SequenceSynthetic
139gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga
cagagtcacc 60atcacttgct gggccagtca ggacattagc agttatttag cctggtatca
gcaaaaacca 120gggatagccc ctaagctcct gatctatgct gcatccactt
tgcaaagtgg ggtcccatca 180aggttcggcg gcagtggatc tgggacagaa
ttcactctca caatcagcag cctgcagcct 240gaagattttg caacttatta
ctgtcaacag cttaatagtt accctcggac gttcggccaa 300gggaccaagg
tggaaatcaa a 321140107PRTArtificial SequenceSynthetic 140Asp Ile
Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15
Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Ser Ser Tyr 20
25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu
Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg
Phe Gly Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
Gln Leu Asn Ser Tyr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys 100 105 141384DNAArtificial SequenceSynthetic
141caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac
cctgtccctc 60acctgcactg tctctgggga ctccatcaat acttactact ggagctggat
ccggcagccc 120ccagggaagg gactggagtg gattgggtat atctattata
gtggaaccac caactacaac 180ccctccctca agagtcgagt caccatatca
gtagacacgt ccaagaacca gttctccctg 240aagctgagct ctgtgaccgc
tgcggacacg gccgtgtatt actgtgcgag agagaggatt 300actatgattc
ggggagttac cctctactat tactcctacg gtatggacgt ctggggccaa
360gggaccacgg tcaccgtctc ctca 384142128PRTArtificial
SequenceSynthetic 142Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
Val Lys Pro Ser Glu1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser
Gly Asp Ser Ile Asn Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln
Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr
Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu65 70 75 80 Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Arg Ile Thr Met Ile Arg Gly Val Thr Leu Tyr Tyr Tyr Ser
100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser 115 120 125 143321DNAArtificial SequenceSynthetic
143gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga
cagagtcacc 60atcacttgcc gggcaagtca ggacattagc agttatttag gctggtatca
gcagaaacca 120gggaaagccc ctaagcgcct gatctatgct gcatccagtt
tgcaaagtgg ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa
ttcactctca caatcagcag cctgcagcct 240gaagattttg caacttatta
ctgtcaacag cttaatagtt accctcggac gttcggccaa 300gggaccaagg
tggaaatcaa a 321144107PRTArtificial SequenceSynthetic 144Asp Ile
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 20
25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu
Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
Gln Leu Asn Ser Tyr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys 100 105 145378DNAArtificial SequenceSynthetic
145caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt
gcgacaggcc 120cctggacaag gacttgagtt aatgggatgg attagtggtt
acaatggtaa cacaaactat 180gcacaagaac tccaggccag agtcaccatg
accacagaca catccacgag cacagcctac 240atggagctga ggaacctgag
atctgacgac acggccgtat attactgtgc gagagataga 300gtcgttgtag
cagctgctaa ttactacttt tattctatgg acgtctgggg ccaagggacc
360acggtcaccg tctcctca 378146126PRTArtificial SequenceSynthetic
146Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Leu Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Asn
Tyr Ala Gln Glu Leu 50 55 60 Gln Ala Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Asn Leu Arg
Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Val
Val Val Ala Ala Ala Asn Tyr Tyr Phe Tyr Ser 100 105 110 Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
14724DNAArtificial SequenceSynthetic 147ggttacacct ttaccaacta tggt
241488PRTArtificial SequenceSynthetic 148Gly Tyr Thr Phe Thr Asn
Tyr Gly1 5 14924DNAArtificial SequenceSynthetic 149attagtggtt
acaatggtaa caca 241508PRTArtificial SequenceSynthetic 150Ile Ser
Gly Tyr Asn Gly Asn Thr1 5 15157DNAArtificial SequenceSynthetic
151gcgagagata gagtcgttgt agcagctgct aattactact tttattctat ggacgtc
5715219PRTArtificial SequenceSynthetic 152Ala Arg Asp Arg Val Val
Val Ala Ala Ala Asn Tyr Tyr Phe Tyr Ser1 5 10 15 Met Asp
Val153339DNAArtificial SequenceSynthetic 153gccatccaga tgacccagtc
tccactctcc ctgtccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gagacaccta cttgaattgg 120tttcagcaga
ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgctttcac
actgaaaatc 240agcggggtgg aggccgagga tgttggggtt tactactgca
tgcaagctac acactggcct 300cggacgttcg gccaagggac caaggtggaa atcaaacga
339154113PRTArtificial SequenceSynthetic 154Ala Ile Gln Met Thr Gln
Ser Pro Leu Ser Leu Ser Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asp Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys
Ile65 70 75 80 Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Ala 85 90 95 Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys 100 105 110 Arg15533DNAArtificial
SequenceSynthetic 155caaagcctcg tatacagtga tggagacacc tac
3315611PRTArtificial SequenceSynthetic 156Gln Ser Leu Val Tyr Ser
Asp Gly Asp Thr Tyr1 5 10 1579DNAArtificial SequenceSynthetic
157aaggtttct 91583PRTArtificial SequenceSynthetic 158Lys Val Ser1
15927DNAArtificial SequenceSynthetic 159atgcaagcta cacactggcc
tcggacg 271609PRTArtificial SequenceSynthetic 160Met Gln Ala Thr
His Trp Pro Arg Thr1 5 161378DNAArtificial SequenceSynthetic
161caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt
gcgacaggcc 120cctggacaag gacttgagtt aatgggatgg attagtggtt
acaatggtaa cacaaactat 180gcacaagaac tccaggccag agtcaccatg
accacagaca catccacgag cacagcctac 240atggagctga ggaacctgag
atctgacgac acggccgtat attactgtgc gagagataga 300gtcgttgtag
cagctgctaa ttactacttt tattctatgg acgtctgggg ccaagggacc
360acggtcaccg tctcctca 378162126PRTArtificial SequenceSynthetic
162Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Leu Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Asn
Tyr Ala Gln Glu Leu 50 55 60 Gln Ala Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Asn Leu Arg
Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Val
Val Val Ala Ala Ala Asn Tyr Tyr Phe Tyr Ser 100 105 110 Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
163336DNAArtificial SequenceSynthetic 163gatgttgtga tgactcagtc
tccactctcc ctgtccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gagacaccta cttgaattgg 120tttcagcaga
ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgctttcac
actgaaaatc 240agcggggtgg aggccgagga tgttggggtt tactactgca
tgcaagctac acactggcct 300cggacgttcg gccaagggac caaggtggaa atcaaa
336164112PRTArtificial SequenceSynthetic 164Asp Val Val Met Thr Gln
Ser Pro Leu Ser Leu Ser Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asp Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys
Ile65 70 75 80 Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Ala 85 90 95 Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys 100 105 110 165378DNAArtificial
SequenceSynthetic 165caggttcagc tggtgcagtc tggagctgag gtgaagaagc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactatggta
tcagctgggt gcgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
attagtggtt acaatggtaa cacaaactat 180gcacagaagc tccagggcag
agtcaccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccgtgt attactgtgc gagagataga
300gtcgttgtag cagctgctaa ttactacttt tattctatgg acgtctgggg
ccaagggacc 360acggtcaccg tctcctca 378166126PRTArtificial
SequenceSynthetic 166Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly
Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg
Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Arg Val Val Val Ala Ala Ala Asn Tyr Tyr Phe Tyr Ser
100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125 167336DNAArtificial SequenceSynthetic 167gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gagacaccta cttgaattgg
120tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaagctac acactggcct 300cggacgttcg gccaagggac
caaggtggaa atcaaa 336168112PRTArtificial SequenceSynthetic 168Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asp Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Thr His Trp Pro Arg Thr
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110
169375DNAArtificial SequenceSynthetic 169caggtccact tgaaggagtc
tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60acctgcacct tctctggatt
ctcactcatc actagtggag tgggtgtggg ctggattcgt 120cagccccccg
gaaaggccct ggagtggctt gcactcattt attggaatgg tgataagcgc
180tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa
aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg gacacagcca
catattactg tgcacacagg 300ataactgaaa ctagttacta cttctactac
ggtatggacg tctggggcca agggaccacg 360gtcaccgtct cctca
375170125PRTArtificial SequenceSynthetic 170Gln Val His Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ile Thr Ser 20 25 30 Gly Val
Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Gly Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile Thr Glu Thr Ser Tyr Tyr
Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser 115 120 125 17130DNAArtificial SequenceSynthetic
171ggattctcac tcatcactag tggagtgggt 3017210PRTArtificial
SequenceSynthetic 172Gly Phe Ser Leu Ile Thr Ser Gly Val Gly1 5 10
17321DNAArtificial SequenceSynthetic 173atttattgga atggtgataa g
211747PRTArtificial SequenceSynthetic 174Ile Tyr Trp Asn Gly Asp
Lys1 5 17551DNAArtificial SequenceSynthetic 175gcacacagga
taactgaaac tagttactac ttctactacg gtatggacgt c 5117617PRTArtificial
SequenceSynthetic 176Ala His Arg Ile Thr Glu Thr Ser Tyr Tyr Phe
Tyr Tyr Gly Met Asp1 5 10 15 Val177339DNAArtificial
SequenceSynthetic 177gacatccaga tgacccagtc tccactctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtcatg
gatacgacta tttggattgg 120tacctgcaga agccagggca gtctccacag
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg
300ctcactttcg gcggagggac caaggtggaa atcaaacga
339178113PRTArtificial SequenceSynthetic 178Asp Ile Gln Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly
Tyr Asp Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr
Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly
Thr Lys Val Glu Ile Lys 100 105 110 Arg17933DNAArtificial
SequenceSynthetic 179cagagcctcc tgcatagtca tggatacgac tat
3318011PRTArtificial SequenceSynthetic 180Gln Ser Leu Leu His Ser
His Gly Tyr Asp Tyr1 5 10 1819DNAArtificial SequenceSynthetic
181ttgggttct 91823PRTArtificial SequenceSynthetic 182Leu Gly Ser1
18327DNAArtificial SequenceSynthetic 183atgcaagctc tacaaactcc
gctcact 271849PRTArtificial SequenceSynthetic 184Met Gln Ala Leu
Gln Thr Pro Leu Thr1 5 185375DNAArtificial SequenceSynthetic
185cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac
cctcacgctg 60acctgcacct tctctggatt ctcactcatc actagtggag tgggtgtggg
ctggattcgt 120cagccccccg gaaaggccct ggagtggctt gcactcattt
attggaatgg tgataagcgc 180tacagcccat ctctgaagag caggctcacc
atcaccaagg acacctccaa aaaccaggtg 240gtccttacaa tgaccaacat
ggaccctgtg gacacagcca catattactg tgcacacagg 300ataactgaaa
ctagttacta cttctactac ggtatggacg tctggggcca agggaccacg
360gtcaccgtct cctca 375186125PRTArtificial SequenceSynthetic 186Gln
Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10
15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ile Thr Ser
20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala
Leu Glu 35 40 45 Trp Leu Ala Leu Ile Tyr Trp Asn Gly Asp Lys Arg
Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp
Thr Ser Lys Asn Gln Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp
Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile Thr
Glu Thr Ser Tyr Tyr Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 187336DNAArtificial
SequenceSynthetic 187gatattgtga tgactcagtc tccactctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtcatg
gatacgacta tttggattgg 120tacctgcaga agccagggca gtctccacag
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg
300ctcactttcg gcggagggac caaggtggag atcaaa 336188112PRTArtificial
SequenceSynthetic 188Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly Tyr Asp Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 189375DNAArtificial SequenceSynthetic 189cagatcacct
tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60acctgcacct
tctctggatt ctcactcatc actagtggag tgggtgtggg ctggatccgt
120cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatgg
tgataagcgc 180tacagcccat ctctgaagag caggctcacc atcaccaagg
acacctccaa aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg
gacacagcca catattactg tgcacacagg 300ataactgaaa ctagttacta
cttctactac ggtatggacg tctggggcca agggaccacg 360gtcaccgtct cctca
375190125PRTArtificial SequenceSynthetic 190Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ile Thr Ser 20 25 30 Gly Val
Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Gly Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile Thr Glu Thr Ser Tyr Tyr
Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser 115 120 125 191336DNAArtificial SequenceSynthetic
191gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga
gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtcatg gatacgacta
tttggattgg 120tacctgcaga agccagggca gtctccacag ctcctgatct
atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt
ggatcaggca cagattttac actgaaaatc 240agcagagtgg aggctgagga
tgttggggtt tattactgca tgcaagctct acaaactccg 300ctcactttcg
gcggagggac caaggtggag atcaaa 336192112PRTArtificial
SequenceSynthetic 192Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly Tyr Asp Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 193375DNAArtificial SequenceSynthetic 193cagatcacct
tgaaggagtc tggtcctact ctggtgaaac cctcacagac cctcacgctg 60acctgcacct
tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt
120cagcccccag gaaaggccct ggagtggctt gcactcattt attggaattc
tgataagcgc 180tacagcccat ctctgaagag caggctcacc atcaccaagg
acacctccaa aaaccaggta 240gtccttacaa tgaccaacat ggaccctgtg
gacacagcca catattactg tgcacacaga 300catgacagct cgtcctacta
cttctactac ggtatggacg tctggggcca agggatcacg 360gtcaccgtct cctca
375194125PRTArtificial SequenceSynthetic 194Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Ser Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val
Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Ser Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg His Asp Ser Ser Ser Tyr Tyr
Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Ile Thr Val
Thr Val Ser Ser 115 120 125 19530DNAArtificial SequenceSynthetic
195gggttctcac tcagcactag tggagtgggt 3019610PRTArtificial
SequenceSynthetic 196Gly Phe Ser Leu Ser Thr Ser Gly Val Gly1 5 10
19721DNAArtificial SequenceSynthetic 197atttattgga attctgataa g
211987PRTArtificial SequenceSynthetic 198Ile Tyr Trp Asn Ser Asp
Lys1 5 19951DNAArtificial SequenceSynthetic 199gcacacagac
atgacagctc gtcctactac ttctactacg gtatggacgt c 5120017PRTArtificial
SequenceSynthetic 200Ala His Arg His Asp Ser Ser Ser Tyr Tyr Phe
Tyr Tyr Gly Met Asp1 5 10 15 Val201339DNAArtificial
SequenceSynthetic 201gacatccaga tgacccagtc tccgctctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctc catagtcatg
gatacaacta tttggattgg 120tacctgcaga agccagggca gtctccacaa
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcggt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttgggatt tattactgca tgcaagctct acagactcct
300ctcactttcg gcggagggac caaggtggag atcaaacga
339202113PRTArtificial SequenceSynthetic 202Asp Ile Gln Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly
Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys
Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys 100 105 110 Arg20333DNAArtificial
SequenceSynthetic 203cagagcctcc tccatagtca tggatacaac tat
3320411PRTArtificial SequenceSynthetic 204Gln Ser Leu Leu His Ser
His Gly Tyr Asn Tyr1 5 10 2059DNAArtificial SequenceSynthetic
205ttgggttct 92063PRTArtificial SequenceSynthetic 206Leu Gly Ser1
20727DNAArtificial SequenceSynthetic 207atgcaagctc tacagactcc
tctcact 272089PRTArtificial SequenceSynthetic 208Met Gln Ala Leu
Gln Thr Pro Leu Thr1 5 209375DNAArtificial SequenceSynthetic
209cagatcacct tgaaggagtc tggtcctact ctggtgaaac cctcacagac
cctcacgctg 60acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg
ctggatccgt 120cagcccccag gaaaggccct ggagtggctt gcactcattt
attggaattc tgataagcgc 180tacagcccat ctctgaagag caggctcacc
atcaccaagg acacctccaa aaaccaggta 240gtccttacaa tgaccaacat
ggaccctgtg gacacagcca catattactg tgcacacaga 300catgacagct
cgtcctacta cttctactac ggtatggacg tctggggcca agggaccacg
360gtcaccgtct cctca 375210125PRTArtificial SequenceSynthetic 210Gln
Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln1 5 10
15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala
Leu Glu 35 40 45 Trp Leu Ala Leu Ile Tyr Trp Asn Ser Asp Lys Arg
Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp
Thr Ser Lys Asn Gln Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp
Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg His Asp
Ser Ser Ser Tyr Tyr Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 211336DNAArtificial
SequenceSynthetic 211gatattgtga tgactcagtc tccgctctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctc catagtcatg
gatacaacta tttggattgg 120tacctgcaga agccagggca gtctccacaa
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcggt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttgggatt tattactgca tgcaagctct acagactcct
300ctcactttcg gcggagggac caaggtggag atcaaa 336212112PRTArtificial
SequenceSynthetic 212Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 213375DNAArtificial SequenceSynthetic 213cagatcacct
tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60acctgcacct
tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt
120cagcccccag gaaaggccct ggagtggctt gcactcattt attggaattc
tgataagcgc 180tacagcccat ctctgaagag caggctcacc atcaccaagg
acacctccaa aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg
gacacagcca catattactg tgcacacaga 300catgacagct cgtcctacta
cttctactac ggtatggacg tctggggcca agggaccacg 360gtcaccgtct cctca
375214125PRTArtificial SequenceSynthetic 214Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val
Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Ser Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg His Asp Ser Ser Ser Tyr Tyr
Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser 115 120 125 215336DNAArtificial SequenceSynthetic
215gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga
gccggcctcc 60atctcctgca ggtctagtca gagcctcctc catagtcatg gatacaacta
tttggattgg 120tacctgcaga agccagggca gtctccacag ctcctgatct
atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt
ggatcaggca cagattttac actgaaaatc 240agcagagtgg aggctgagga
tgttggggtt tattactgca tgcaagctct acagactcct 300ctcactttcg
gcggagggac caaggtggag atcaaa 336216112PRTArtificial
SequenceSynthetic 216Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 His Gly Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 217381DNAArtificial SequenceSynthetic 217gagatgcaac
tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacctttagt agtcactgga tgaagtgggt ccgccaggct
120ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga
gaaatactat 180gtggactctg tgaagggccg attcaccatc tccagagaca
acgccaagaa ctcactgttt 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatatt 300gtactaatgg tctatgatat
ggactactac tactacggta tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381218127PRTArtificial SequenceSynthetic 218Glu Met
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Ser His 20 25 30 Trp Met Lys Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Asn Gln Asp Gly Ser
Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Asp Ile Val Leu Met Val Tyr Asp Met Asp Tyr Tyr Tyr Tyr 100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120
125 21924DNAArtificial SequenceSynthetic 219ggattcacct ttagtagtca
ctgg 242208PRTArtificial SequenceSynthetic 220Gly Phe Thr Phe Ser
Ser His Trp1 5 22124DNAArtificial SequenceSynthetic 221ataaaccaag
atggaagtga gaaa 242228PRTArtificial SequenceSynthetic 222Ile Asn
Gln Asp Gly Ser Glu Lys1 5 22360DNAArtificial SequenceSynthetic
223gcgagagata ttgtactaat ggtctatgat atggactact actactacgg
tatggacgtc 6022420PRTArtificial SequenceSynthetic 224Ala Arg Asp
Ile Val Leu Met Val Tyr Asp Met Asp Tyr Tyr Tyr Tyr1 5 10 15 Gly
Met Asp Val 20 225336DNAArtificial SequenceSynthetic 225gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gaaacaacta tttggattgg
120tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaaactct acaaactccg 300ctcactttcg gcggagggac
caaggtggag atcaaa 336226112PRTArtificial SequenceSynthetic 226Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Thr 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
22733DNAArtificial SequenceSynthetic 227cagagcctcc tgcatagtaa
tggaaacaac tat 3322811PRTArtificial SequenceSynthetic 228Gln Ser
Leu Leu His Ser Asn Gly Asn Asn Tyr1 5 10 2299DNAArtificial
SequenceSynthetic 229ttgggttct 92303PRTArtificial SequenceSynthetic
230Leu Gly Ser1 23127DNAArtificial SequenceSynthetic 231atgcaaactc
tacaaactcc gctcact 272329PRTArtificial SequenceSynthetic 232Met Gln
Thr Leu Gln Thr Pro Leu Thr1 5 233381DNAArtificial
SequenceSynthetic 233gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
ctggggggtc cctgagactc 60tcctgtgcag cctctggatt cacctttagt agtcactgga
tgaagtgggt ccgccaggct 120ccagggaagg ggctggagtg ggtggccaac
ataaaccaag atggaagtga gaaatactat 180gtggactctg tgaagggccg
attcaccatc tccagagaca acgccaagaa ctcactgttt 240ctgcaaatga
acagcctgag agccgaggac acggctgtgt attactgtgc gagagatatt
300gtactaatgg tctatgatat ggactactac tactacggta tggacgtctg
gggccaaggg 360accacggtca ccgtctcctc a 381234127PRTArtificial
SequenceSynthetic 234Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Ser His 20 25 30 Trp Met Lys Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Asn Gln
Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Ile Val Leu Met Val Tyr Asp Met Asp Tyr Tyr Tyr Tyr
100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 235336DNAArtificial SequenceSynthetic 235gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gaaacaacta tttggattgg
120tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaaactct acaaactccg 300ctcactttcg gcggagggac
caaggtggag atcaaa 336236112PRTArtificial SequenceSynthetic 236Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Thr 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
237381DNAArtificial SequenceSynthetic 237gaggtgcagc tggtggagtc
tgggggaggc ttggtccagc ctggggggtc cctgagactc 60tcctgtgcag cctctggatt
cacctttagt agtcactgga tgagctgggt ccgccaggct 120ccagggaagg
ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat
180gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa
ctcactgtat 240ctgcaaatga acagcctgag agccgaggac acggctgtgt
attactgtgc gagagatatt 300gtactaatgg tctatgatat ggactactac
tactacggta tggacgtctg ggggcaaggg 360accacggtca ccgtctcctc a
381238127PRTArtificial SequenceSynthetic 238Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 20 25 30 Trp Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Asp Ile Val Leu Met Val Tyr Asp Met
Asp Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser 115 120 125 239336DNAArtificial
SequenceSynthetic 239gatattgtga tgactcagtc tccactctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtaatg
gaaacaacta tttggattgg 120tacctgcaga agccagggca gtctccacag
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtt tattactgca tgcaaactct acaaactccg
300ctcactttcg gcggagggac caaggtggag atcaaa 336240112PRTArtificial
SequenceSynthetic 240Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Asn Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 241381DNAArtificial SequenceSynthetic 241caggtgcagc
tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag
tctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct
120ccaggcaagg ggctggagtg ggtggcagct atatcatatg atggaagtaa
taaatactat 180gtagactccg tgaagggccg attcaccatc tccagagaca
attccaagaa aacgctgtat 240ctgcaaatga acagcctgag agctgaggac
acggctgtgt ataattgtgc gaaaaatatt 300gtactagtga tgtatgatat
agactatcac tactatggga tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381242127PRTArtificial SequenceSynthetic 242Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Val
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Lys Thr Leu Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Asn Cys 85 90 95 Ala Lys Asn Ile Val Leu Val
Met Tyr Asp Ile Asp Tyr His Tyr Tyr 100 105 110 Gly Met Asp Val Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
24324DNAArtificial SequenceSynthetic 243ggattcacct tcagtagcta tggc
242448PRTArtificial SequenceSynthetic 244Gly Phe Thr Phe Ser Ser
Tyr Gly1 5 24524DNAArtificial SequenceSynthetic 245atatcatatg
atggaagtaa taaa 242468PRTArtificial SequenceSynthetic 246Ile Ser
Tyr Asp Gly Ser Asn Lys1 5 24760DNAArtificial SequenceSynthetic
247gcgaaaaata ttgtactagt gatgtatgat atagactatc actactatgg
gatggacgtc 6024820PRTArtificial SequenceSynthetic 248Ala Lys Asn
Ile Val Leu Val Met Tyr Asp Ile Asp Tyr His Tyr Tyr1 5 10 15 Gly
Met Asp Val 20 249336DNAArtificial SequenceSynthetic 249gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg
120tacctgcaga agccagggca gtctccacaa ctcctgatct atttgggttt
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaagctct acaaactcct 300ctcactttcg gcggagggac
caaggtggag atcaga 336250112PRTArtificial SequenceSynthetic 250Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 100 105 110
25133DNAArtificial SequenceSynthetic 251cagagcctcc tgcatagtaa
tggatacaac tat 3325211PRTArtificial SequenceSynthetic 252Gln Ser
Leu Leu His Ser Asn Gly Tyr Asn Tyr1 5 10 2539DNAArtificial
SequenceSynthetic 253ttgggtttt 92543PRTArtificial SequenceSynthetic
254Leu Gly Phe1 25527DNAArtificial SequenceSynthetic 255atgcaagctc
tacaaactcc tctcact 272569PRTArtificial SequenceSynthetic 256Met Gln
Ala Leu Gln Thr Pro Leu Thr1 5 257381DNAArtificial
SequenceSynthetic 257caggtgcagc tggtggagtc tgggggaggc gtggtccagc
ctgggaggtc cctgagactc 60tcctgtgcag tctctggatt caccttcagt agctatggca
tgcactgggt ccgccaggct 120ccaggcaagg ggctggagtg ggtggcagct
atatcatatg atggaagtaa taaatactat 180gtagactccg tgaagggccg
attcaccatc tccagagaca attccaagaa aacgctgtat 240ctgcaaatga
acagcctgag agctgaggac acggctgtgt ataattgtgc gaaaaatatt
300gtactagtga tgtatgatat agactatcac tactatggga tggacgtctg
gggccaaggg 360accacggtca ccgtctcctc a 381258127PRTArtificial
SequenceSynthetic 258Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val
Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr
Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asn Cys 85 90
95 Ala Lys Asn Ile Val Leu Val Met Tyr Asp Ile Asp Tyr His Tyr Tyr
100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 259336DNAArtificial SequenceSynthetic 259gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg
120tacctgcaga agccagggca gtctccacaa ctcctgatct atttgggttt
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaagctct acaaactcct 300ctcactttcg gcggagggac
caaggtggag atcaaa 336260112PRTArtificial SequenceSynthetic 260Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
261381DNAArtificial SequenceSynthetic 261caggtgcagc tggtggagtc
tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag cctctggatt
caccttcagt agctatggca tgcactgggt ccgccaggct 120ccaggcaagg
ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat
180gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa
cacgctgtat 240ctgcaaatga acagcctgag agctgaggac acggctgtgt
attactgtgc gaaaaatatt 300gtactagtga tgtatgatat agactatcac
tactatggga tggacgtctg ggggcaaggg 360accacggtca ccgtctcctc a
381262127PRTArtificial SequenceSynthetic 262Gln Val Gln Leu Val Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Lys Asn Ile Val Leu Val Met Tyr Asp Ile Asp Tyr
His Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser 115 120 125 263336DNAArtificial SequenceSynthetic
263gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga
gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta
tttggattgg 120tacctgcaga agccagggca gtctccacag ctcctgatct
atttgggttt taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt
ggatcaggca cagattttac actgaaaatc 240agcagagtgg aggctgagga
tgttggggtt tattactgca tgcaagctct acaaactcct 300ctcactttcg
gcggagggac caaggtggag atcaaa 336264112PRTArtificial
SequenceSynthetic 264Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 265381DNAArtificial SequenceSynthetic 265caggtgcagc
tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag
tctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct
120ccaggcaagg ggctggagtg ggtggcagct atatcatatg atggaagtaa
taaatactat 180gtagactccg tgaagggccg attcaccatc tccagagaca
attccaagaa aacgctgtat 240ctgcaaatga acagcctgag agctgaggac
acggctgtgt ataattgtgc gaaaaatatt 300gtactagtga tgtatgatat
agactatcac tactatggga tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381266127PRTArtificial SequenceSynthetic 266Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Val
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Lys Thr Leu Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Asn Cys 85 90 95 Ala Lys Asn Ile Val Leu Val
Met Tyr Asp Ile Asp Tyr His Tyr Tyr 100 105 110 Gly Met Asp Val Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
26724DNAArtificial SequenceSynthetic 267ggattcacct tcagtagcta tggc
242688PRTArtificial SequenceSynthetic 268Gly Phe Thr Phe Ser Ser
Tyr Gly1 5 26924DNAArtificial SequenceSynthetic 269atatcatatg
atggaagtaa taaa 242708PRTArtificial SequenceSynthetic 270Ile Ser
Tyr Asp Gly Ser Asn Lys1 5 27160DNAArtificial SequenceSynthetic
271gcgaaaaata ttgtactagt gatgtatgat atagactatc actactatgg
gatggacgtc 6027220PRTArtificial SequenceSynthetic 272Ala Lys Asn
Ile Val Leu Val Met Tyr Asp Ile Asp Tyr His Tyr Tyr1 5 10 15 Gly
Met Asp Val 20 273336DNAArtificial SequenceSynthetic 273gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg
120tacctgcaga agccagggca gtctccacaa ctcctgatct atttgggttt
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaagctct acaaactcct 300ctcactttcg gcggagggac
caaggtggag atcaga 336274112PRTArtificial SequenceSynthetic 274Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 100 105 110
27533DNAArtificial SequenceSynthetic 275cagagcctcc tgcatagtaa
tggatacaac tat 3327611PRTArtificial SequenceSynthetic 276Gln Ser
Leu Leu His Ser Asn Gly Tyr Asn Tyr1 5 10 2779DNAArtificial
SequenceSynthetic 277ttgggtttt 92783PRTArtificial SequenceSynthetic
278Leu Gly Phe1 27927DNAArtificial SequenceSynthetic 279atgcaagctc
tacaaactcc tctcact 272809PRTArtificial SequenceSynthetic 280Met Gln
Ala Leu Gln Thr Pro Leu Thr1 5 281381DNAArtificial
SequenceSynthetic 281caggtgcagc tggtggagtc tgggggaggc gtggtccagc
ctgggaggtc cctgagactc 60tcctgtgcag tctctggatt caccttcagt agctatggca
tgcactgggt ccgccaggct 120ccaggcaagg ggctggagtg ggtggcagct
atatcatatg atggaagtaa taaatactat 180gtagactccg tgaagggccg
attcaccatc tccagagaca attccaagaa aacgctgtat 240ctgcaaatga
acagcctgag agctgaggac acggctgtgt ataattgtgc gaaaaatatt
300gtactagtga tgtatgatat agactatcac tactatggga tggacgtctg
gggccaaggg 360accacggtca ccgtctcctc a 381282127PRTArtificial
SequenceSynthetic 282Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val
Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr
Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asn Cys 85 90
95 Ala Lys Asn Ile Val Leu Val Met Tyr Asp Ile Asp Tyr His Tyr Tyr
100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 283336DNAArtificial SequenceSynthetic 283gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg
120tacctgcaga agccagggca gtctccacaa ctcctgatct atttgggttt
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaagctct acaaactcct 300ctcactttcg gcggagggac
caaggtggag atcaaa 336284112PRTArtificial SequenceSynthetic 284Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
285381DNAArtificial SequenceSynthetic 285caggtgcagc tggtggagtc
tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60tcctgtgcag cctctggatt
caccttcagt agctatggca tgcactgggt ccgccaggct 120ccaggcaagg
ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat
180gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa
cacgctgtat 240ctgcaaatga acagcctgag agctgaggac acggctgtgt
attactgtgc gaaaaatatt 300gtactagtga tgtatgatat agactatcac
tactatggga tggacgtctg ggggcaaggg 360accacggtca ccgtctcctc a
381286127PRTArtificial SequenceSynthetic 286Gln Val Gln Leu Val Glu
Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Asn Ile Val Leu Val Met Tyr Asp Ile
Asp Tyr His Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser 115 120 125 287336DNAArtificial
SequenceSynthetic 287gatattgtga tgactcagtc tccactctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catagtaatg
gatacaacta tttggattgg 120tacctgcaga agccagggca gtctccacag
ctcctgatct atttgggttt taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcct
300ctcactttcg gcggagggac caaggtggag atcaaa 336288112PRTArtificial
SequenceSynthetic 288Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 289372DNAArtificial SequenceSynthetic 289cagatcacct
tgaaggagtc tggtcctacg ctggtaaaac ccacacagac cctcacgctg 60acctgcacct
tctctgggtt ctcactcagc gctagtggag tgggtgtggg ctggttccgt
120cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatga
tgataagcgt 180tacagcccat ctctaaagaa cagcctcacc atcaccaagg
acacctccaa aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg
gacacagcca catattactg tgcacacaga 300atacatctat ggtcctactt
ctactacggt atggacgtct ggggccaagg gaccacggtc 360accgtctcct ca
372290124PRTArtificial SequenceSynthetic 290Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ala Ser 20 25 30 Gly Val
Gly Val Gly Trp Phe Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Asn Ser Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile His Leu Trp Ser Tyr Phe
Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr
Val Ser Ser 115 120 29130DNAArtificial SequenceSynthetic
291gggttctcac tcagcgctag tggagtgggt 3029210PRTArtificial
SequenceSynthetic 292Gly Phe Ser Leu Ser Ala Ser Gly Val Gly1 5 10
29321DNAArtificial SequenceSynthetic 293atttattgga atgatgataa g
212947PRTArtificial SequenceSynthetic 294Ile Tyr Trp Asn Asp Asp
Lys1 5 29548DNAArtificial SequenceSynthetic 295gcacacagaa
tacatctatg gtcctacttc tactacggta tggacgtc 4829616PRTArtificial
SequenceSynthetic 296Ala His Arg Ile His Leu Trp Ser Tyr Phe Tyr
Tyr Gly Met Asp Val1 5 10 15 297336DNAArtificial SequenceSynthetic
297gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga
gccggcctcc 60atctcctgca ggtctagtca gactctcctg catagtaatg gatacaacta
tttcgattgg 120tacctgcaga agccagggca gtctccacag ctcctgatct
atttgggttc taatcgggcc 180tccggggtcc ctgacagatt cagtggcagt
ggatcaggca cagattttac actgaaaatc 240agcagagtgg aggctgagga
tgttggaatt tattactgca tgcaagctct acaaactcct 300ctcactttcg
gcggagggac caaggtggag atcaga 336298112PRTArtificial
SequenceSynthetic 298Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Thr Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Phe Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg
100 105 110 29933DNAArtificial SequenceSynthetic 299cagactctcc
tgcatagtaa tggatacaac tat 3330011PRTArtificial SequenceSynthetic
300Gln Thr Leu Leu His Ser Asn Gly Tyr Asn Tyr1 5 10
3019DNAArtificial SequenceSynthetic 301ttgggttct 93023PRTArtificial
SequenceSynthetic 302Leu Gly Ser1 30327DNAArtificial
SequenceSynthetic 303atgcaagctc tacaaactcc tctcact
273049PRTArtificial SequenceSynthetic 304Met Gln Ala Leu Gln Thr
Pro Leu Thr1 5 305372DNAArtificial SequenceSynthetic 305cagatcacct
tgaaggagtc tggtcctacg ctggtaaaac ccacacagac cctcacgctg 60acctgcacct
tctctgggtt ctcactcagc gctagtggag tgggtgtggg ctggttccgt
120cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatga
tgataagcgt 180tacagcccat ctctaaagaa cagcctcacc atcaccaagg
acacctccaa aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg
gacacagcca catattactg tgcacacaga 300atacatctat ggtcctactt
ctactacggt atggacgtct ggggccaagg gaccacggtc 360accgtctcct ca
372306124PRTArtificial SequenceSynthetic 306Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ala Ser 20 25 30 Gly Val
Gly Val Gly Trp Phe Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Asn Ser Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile His Leu Trp Ser Tyr Phe
Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr
Val Ser Ser 115 120 307336DNAArtificial SequenceSynthetic
307gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gactctcctg catagtaatg gatacaacta tttcgattgg
120tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc
taatcgggcc 180tccggggtcc ctgacagatt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggaatt
tattactgca tgcaagctct acaaactcct 300ctcactttcg gcggagggac
caaggtggag atcaaa 336308112PRTArtificial SequenceSynthetic 308Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Leu Leu His Ser
20 25 30 Asn Gly Tyr Asn Tyr Phe Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110
309372DNAArtificial SequenceSynthetic 309cagatcacct tgaaggagtc
tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60acctgcacct tctctgggtt
ctcactcagc gctagtggag tgggtgtggg ctggatccgt 120cagcccccag
gaaaggccct ggagtggctt gcactcattt attggaatga tgataagcgc
180tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa
aaaccaggtg 240gtccttacaa tgaccaacat ggaccctgtg gacacagcca
catattactg tgcacacaga 300atacatctat ggtcctactt ctactacggt
atggacgtct gggggcaagg gaccacggtc 360accgtctcct ca
372310124PRTArtificial SequenceSynthetic 310Gln Ile Thr Leu Lys Glu
Ser Gly Pro Thr Leu Val Lys Pro Thr Gln1 5 10 15 Thr Leu Thr Leu
Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ala Ser 20 25 30 Gly Val
Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50
55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln
Val65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala
Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ile His Leu Trp Ser Tyr Phe
Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr
Val Ser Ser 115 120 311336DNAArtificial SequenceSynthetic
311gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga
gccggcctcc 60atctcctgca ggtctagtca gactctcctg catagtaatg gatacaacta
tttggattgg 120tacctgcaga agccagggca gtctccacag ctcctgatct
atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt
ggatcaggca cagattttac actgaaaatc 240agcagagtgg aggctgagga
tgttggggtt tattactgca tgcaagctct acaaactcct 300ctcactttcg
gcggagggac caaggtggag atcaaa 336312112PRTArtificial
SequenceSynthetic 312Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Thr Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110 313381DNAArtificial SequenceSynthetic 313caggttcagc
tggtgcagtc tggacctgag gtgaagaacc ctggggcctc agtgaaggtc 60tcctgcaagg
cttctggtta cacctttacc acctatggta tcagttgggt acgacaggcc
120cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa
aacaaacgat 180gcacagaagt tccaggacag agtcgccatg accacagaca
catccacgag cacagcctac 240atggagctga ggagcctgag atctgacgac
acggccattt attactgttc gagagatcgt 300ttagtagtac cacctgccct
taattattcc tactacgtta tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381314127PRTArtificial SequenceSynthetic 314Gln Val
Gln Leu Val Gln Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20
25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Asp Ala
Gln Lys Phe 50 55 60 Gln Asp Arg Val Ala Met Thr Thr Asp Thr Ser
Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp
Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val
Pro Pro Ala Leu Asn Tyr Ser Tyr Tyr 100 105 110 Val Met Asp Val Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
31524DNAArtificial SequenceSynthetic 315ggttacacct ttaccaccta tggt
243168PRTArtificial SequenceSynthetic 316Gly Tyr Thr Phe Thr Thr
Tyr Gly1 5 31724DNAArtificial SequenceSynthetic 317atcagcggtt
acaatggtaa aaca 243188PRTArtificial SequenceSynthetic 318Ile Ser
Gly Tyr Asn Gly Lys Thr1 5 31960DNAArtificial SequenceSynthetic
319tcgagagatc gtttagtagt accacctgcc cttaattatt cctactacgt
tatggacgtc 6032020PRTArtificial SequenceSynthetic 320Ser Arg Asp
Arg Leu Val Val Pro Pro Ala Leu Asn Tyr Ser Tyr Tyr1 5 10 15 Val
Met Asp Val 20 321336DNAArtificial SequenceSynthetic 321gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tctcagcaga ggccaggtca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336322112PRTArtificial SequenceSynthetic 322Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Ser Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
32333DNAArtificial SequenceSynthetic 323caaagcctcg tatacagtga
tggaaacacc tac 3332411PRTArtificial SequenceSynthetic 324Gln Ser
Leu Val Tyr Ser Asp Gly Asn Thr Tyr1 5 10 3259DNAArtificial
SequenceSynthetic 325aaggtttct 93263PRTArtificial SequenceSynthetic
326Lys Val Ser1 32727DNAArtificial SequenceSynthetic 327atgcaaggta
cacactggcc gtacact 273289PRTArtificial SequenceSynthetic 328Met Gln
Gly Thr His Trp Pro Tyr Thr1 5 329381DNAArtificial
SequenceSynthetic 329caggttcagc tggtgcagtc tggacctgag gtgaagaacc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta
tcagttgggt acgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
atcagcggtt acaatggtaa aacaaacgat 180gcacagaagt tccaggacag
agtcgccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccattt attactgttc gagagatcgt
300ttagtagtac cacctgccct taattattcc tactacgtta tggacgtctg
gggccaaggg 360accacggtca ccgtctcctc a 381330127PRTArtificial
SequenceSynthetic 330Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val
Lys Asn Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly
Tyr Asn Gly Lys Thr Asn Asp Ala Gln Lys Phe 50 55 60 Gln Asp Arg
Val Ala Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85 90
95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu Asn Tyr Ser Tyr Tyr
100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 331336DNAArtificial SequenceSynthetic 331gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tctcagcaga ggccaggtca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336332112PRTArtificial SequenceSynthetic 332Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Ser Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
333381DNAArtificial SequenceSynthetic 333caggttcagc tggtgcagtc
tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta
cacctttacc acctatggta tcagctgggt gcgacaggcc 120cctggacaag
ggcttgagtg gatgggatgg atcagcggtt acaatggtaa aacaaactat
180gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag
cacagcctac 240atggagctga ggagcctgag atctgacgac acggccgtgt
attactgttc gagagatcgt 300ttagtagtac cacctgccct taattattcc
tactacgtta tggacgtctg ggggcaaggg 360accacggtca ccgtctcctc a
381334127PRTArtificial SequenceSynthetic 334Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Tyr Ala Gln Lys Leu 50
55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu
Asn Tyr Ser Tyr Tyr 100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser 115 120 125 335336DNAArtificial
SequenceSynthetic 335gatgttgtga tgactcagtc tccactctcc ctgcccgtca
cccttggaca gccggcctcc 60atctcctgca ggtctagtca aagcctcgta tacagtgatg
gaaacaccta cttgaattgg 120tttcagcaga ggccaggcca atctccaagg
cgcctaattt ataaggtttc taaccgggac 180tctggggtcc cagacagatt
cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240agcagggtgg
aggctgagga tgttggggtt tattactgca tgcaaggtac acactggccg
300tacacttttg gccaggggac caagctggag atcaaa 336336112PRTArtificial
SequenceSynthetic 336Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly Asn Thr Tyr Leu Asn
Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile
Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 85 90
95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 337354DNAArtificial SequenceSynthetic 337gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt agctatagca tggactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta
catatactac 180gcagactctg tgaagggccg attcaccatc tccagagaca
ccgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agacgaggac
acggctgttt attactgtgc gagagagggc 300agtagcagac tttttgacta
ctggggccag ggaaccctgg tcaccgtctc ctca 354338118PRTArtificial
SequenceSynthetic 338Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Asp Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser
Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Glu Gly Ser Ser Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110 Leu Val Thr Val Ser Ser 115 33924DNAArtificial
SequenceSynthetic 339ggattcacct tcagtagcta tagc 243408PRTArtificial
SequenceSynthetic 340Gly Phe Thr Phe Ser Ser Tyr Ser1 5
34124DNAArtificial SequenceSynthetic 341attagtagta gtagtagtta cata
243428PRTArtificial SequenceSynthetic 342Ile Ser Ser Ser Ser Ser
Tyr Ile1 5 34333DNAArtificial SequenceSynthetic 343gcgagagagg
gcagtagcag actttttgac tac 3334411PRTArtificial SequenceSynthetic
344Ala Arg Glu Gly Ser Ser Arg Leu Phe Asp Tyr1 5 10
345321DNAArtificial SequenceSynthetic 345gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagagacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaggtgg agtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gaggattttg caacttatta ctgccaacag tataatagtt
attggtacac ttttggccag 300gggaccaagc tggagatcaa a
321346107PRTArtificial SequenceSynthetic 346Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser
Tyr Trp Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100
105 34718DNAArtificial SequenceSynthetic 347cagagtatta gtagctgg
183486PRTArtificial SequenceSynthetic 348Gln Ser Ile Ser Ser Trp1 5
3499DNAArtificial SequenceSynthetic 349aaggcgtct 93503PRTArtificial
SequenceSynthetic 350Lys Ala Ser1 35127DNAArtificial
SequenceSynthetic 351caacagtata atagttattg gtacact
273529PRTArtificial SequenceSynthetic 352Gln Gln Tyr Asn Ser Tyr
Trp Tyr Thr1 5 353354DNAArtificial SequenceSynthetic 353gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt agctatagca tggactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta
catatactac 180gcagactctg tgaagggccg attcaccatc tccagagaca
ccgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agacgaggac
acggctgttt attactgtgc gagagagggc 300agtagcagac tttttgacta
ctggggccag ggaaccctgg tcaccgtctc ctca 354354118PRTArtificial
SequenceSynthetic 354Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Asp Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser
Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Glu Gly Ser Ser Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110 Leu Val Thr Val Ser Ser 115 355321DNAArtificial
SequenceSynthetic 355gacatccaga tgacccagtc tccttccacc ctgtctgcat
ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca gagtattagt agctggttgg
cctggtatca gcagagacca 120gggaaagccc ctaagctcct gatctataag
gcgtctagtt tagaaggtgg agtcccatca 180aggttcagcg gcagtggatc
tgggacagaa ttcactctca ccatcagcag cctgcagcct 240gaggattttg
caacttatta ctgccaacag tataatagtt attggtacac ttttggccag
300gggaccaagc tggagatcaa a 321356107PRTArtificial SequenceSynthetic
356Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1
5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser
Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Gly Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Tyr Asn Ser Tyr Trp Tyr 85 90 95 Thr Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys 100 105 357354DNAArtificial
SequenceSynthetic 357gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc
ctggggggtc cctgagactc 60tcctgtgcag cctctggatt caccttcagt agctatagca
tgaactgggt ccgccaggct 120ccagggaagg ggctggagtg ggtctcatcc
attagtagta gtagtagtta catatactac 180gcagactcag tgaagggccg
attcaccatc tccagagaca acgccaagaa ctcactgtat 240ctgcaaatga
acagcctgag agccgaggac acggctgtgt attactgtgc gagagagggc
300agtagcagac tttttgacta ctggggccaa ggaaccctgg tcaccgtctc ctca
354358118PRTArtificial SequenceSynthetic 358Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met
Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Ser Ser Arg Leu Phe Asp Tyr
Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115
359321DNAArtificial SequenceSynthetic 359gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tataatagtt
attggtacac ttttggccag 300gggaccaagc tggagatcaa a
321360107PRTArtificial SequenceSynthetic 360Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser
Tyr Trp Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 361384DNAArtificial SequenceSynthetic 361caggtgcacc
tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt gaccactaca tgagctggat ccgccaggct
120ccagggaagg ggctggagtg gatttcatac attagtaatg atggtggtac
caaatactat 180gtggactctg tggagggccg attcatcatt tccagggaca
acgccaagaa ctcattgtat 240ctacatatga acagcctcag agccgacgac
acggccgtgt attactgtgc gagagatcag 300ggatatattg gctacgactc
gtattattac tattcctacg gtatggacgt ctggggccaa 360gggaccacgg
tcaccgtcgc ctca 384362128PRTArtificial SequenceSynthetic 362Gln Val
His Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20
25 30 Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Ile 35 40 45 Ser Tyr Ile Ser Asn Asp Gly Gly Thr Lys Tyr Tyr Val
Asp Ser Val 50 55 60 Glu Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr65 70 75 80 Leu His Met Asn Ser Leu Arg Ala Asp
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gln Gly Tyr Ile
Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser 100 105 110 Tyr Gly Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ala Ser 115 120 125
36324DNAArtificial SequenceSynthetic 363ggattcacct tcagtgacca ctac
243648PRTArtificial SequenceSynthetic 364Gly Phe Thr Phe Ser Asp
His Tyr1 5 36524DNAArtificial SequenceSynthetic 365attagtaatg
atggtggtac caaa 243668PRTArtificial SequenceSynthetic 366Ile Ser
Asn Asp Gly Gly Thr Lys1 5 36763DNAArtificial SequenceSynthetic
367gcgagagatc agggatatat tggctacgac tcgtattatt actattccta
cggtatggac 60gtc 6336821PRTArtificial SequenceSynthetic 368Ala Arg
Asp Gln Gly Tyr Ile Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser1 5 10 15
Tyr Gly Met Asp Val 20 369321DNAArtificial SequenceSynthetic
369aaaattgtgt tgacgcagtc tccaggcacc ctgcctttgt ttccagggga
aagagccacc 60ctctcctgta gggccagtca gagtgttaac aacaaattct tagcctggta
ccagcagaaa 120tctggccagg ctcccaggct cctcatctat ggtgcatcca
gcagggccac tggcatccca 180gacaggttca gtggcagtgg gtctgggacc
gacttcactc tcaccatcag cggactggag 240cctgaagatt ttgaagtgta
ttattgtcaa gtatatggta actcactcac tctcggcgga 300gggaccaagg
tggagatcaa g 321370107PRTArtificial SequenceSynthetic 370Lys Ile
Val Leu Thr Gln Ser Pro Gly Thr Leu Pro Leu Phe Pro Gly1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20
25 30 Phe Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu
Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Gly Leu Glu65 70 75 80 Pro Glu Asp Phe Glu Val Tyr Tyr Cys
Gln Val Tyr Gly Asn Ser Leu 85 90 95 Thr Leu Gly Gly Gly Thr Lys
Val Glu Ile Lys 100 105 37121DNAArtificial SequenceSynthetic
371cagagtgtta acaacaaatt c 213727PRTArtificial SequenceSynthetic
372Gln Ser Val Asn Asn Lys Phe1 5 3739DNAArtificial
SequenceSynthetic 373ggtgcatcc 93743PRTArtificial SequenceSynthetic
374Gly Ala Ser1 37524DNAArtificial SequenceSynthetic 375caagtatatg
gtaactcact cact 243768PRTArtificial SequenceSynthetic 376Gln Val
Tyr Gly Asn Ser Leu Thr1 5 377384DNAArtificial SequenceSynthetic
377caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc
cctgagactc 60tcctgtgcag cctctggatt caccttcagt gaccactaca tgagctggat
ccgccaggct 120ccagggaagg ggctggagtg gatttcatac attagtaatg
atggtggtac caaatactat 180gtggactctg tggagggccg attcatcatt
tccagggaca acgccaagaa ctcattgtat 240ctacatatga acagcctcag
agccgacgac acggccgtgt attactgtgc gagagatcag 300ggatatattg
gctacgactc gtattattac tattcctacg gtatggacgt ctggggccaa
360gggaccacgg tcaccgtctc ctca 384378128PRTArtificial
SequenceSynthetic 378Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Asp His 20 25 30 Tyr Met Ser Trp Ile Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ser Tyr Ile Ser Asn
Asp Gly Gly Thr Lys Tyr Tyr Val Asp Ser Val 50 55 60 Glu Gly Arg
Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
His Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gln Gly Tyr Ile Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser
100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser 115 120 125 379321DNAArtificial SequenceSynthetic
379gaaattgtgt tgacgcagtc tccaggcacc ctgcctttgt ttccagggga
aagagccacc 60ctctcctgta gggccagtca gagtgttaac aacaaattct tagcctggta
ccagcagaaa 120tctggccagg ctcccaggct cctcatctat ggtgcatcca
gcagggccac tggcatccca 180gacaggttca gtggcagtgg gtctgggacc
gacttcactc tcaccatcag cggactggag 240cctgaagatt ttgaagtgta
ttattgtcaa gtatatggta actcactcac tctcggcgga 300gggaccaagg
tggagatcaa a 321380107PRTArtificial SequenceSynthetic 380Glu Ile
Val Leu Thr Gln Ser Pro Gly Thr Leu Pro Leu Phe Pro Gly1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20
25 30 Phe Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu
Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Gly Leu Glu65 70 75 80 Pro Glu Asp Phe Glu Val Tyr Tyr Cys
Gln Val Tyr Gly Asn Ser Leu 85 90 95 Thr Leu Gly Gly Gly Thr Lys
Val Glu Ile Lys 100 105 381384DNAArtificial SequenceSynthetic
381caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc
cctgagactc 60tcctgtgcag cctctggatt caccttcagt gaccactaca tgagctggat
ccgccaggct 120ccagggaagg ggctggagtg ggtttcatac attagtaatg
atggtggtac caaatactac 180gcagactctg tgaagggccg attcaccatc
tccagggaca acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag
agccgaggac acggccgtgt attactgtgc gagagatcag 300ggatatattg
gctacgactc gtattattac tattcctacg gtatggacgt ctgggggcaa
360gggaccacgg tcaccgtctc ctca 384382128PRTArtificial
SequenceSynthetic 382Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Asp His 20 25 30 Tyr Met Ser Trp Ile Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Asn
Asp Gly Gly Thr Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gln Gly Tyr Ile Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser
100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser 115 120 125 383321DNAArtificial SequenceSynthetic
383gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga
aagagccacc 60ctctcctgca gggccagtca gagtgttaac aacaaattct tagcctggta
ccagcagaaa 120cctggccagg ctcccaggct cctcatctat ggtgcatcca
gcagggccac tggcatccca 180gacaggttca gtggcagtgg gtctgggaca
gacttcactc tcaccatcag cagactggag 240cctgaagatt ttgcagtgta
ttactgtcaa gtatatggta actcactcac tttcggcgga 300gggaccaagg
tggagatcaa a 321384107PRTArtificial SequenceSynthetic 384Glu Ile
Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20
25 30 Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Arg Leu Glu65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln Val Tyr Gly Asn Ser Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys 100 105 385360DNAArtificial SequenceSynthetic
385gaggtgcaga aggtggagtc tgggggaggc ctggtcaagc cgggggggtc
cctgagactc 60tcctgtacag cctctggatt caccttcagt acttataaca tgaattgggt
ccgccaggct 120ccagggaagg gactggagtg ggtctcatcc attaggagta
gtagtaatta catatactac 180gcagactcag tgaagggccg attcaccatc
tccagagaca acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag
agccgatgac acggctgtgt attactgtgc gagagatggc 300agcagttggt
acgactactc tgactactgg ggccagggaa ccctggtcac cgtctcctca
360386120PRTArtificial SequenceSynthetic 386Glu Val Gln Lys Val Glu
Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met
Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ser Ile Arg Ser Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser
Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115
120 38724DNAArtificial SequenceSynthetic 387ggattcacct tcagtactta
taac
243888PRTArtificial SequenceSynthetic 388Gly Phe Thr Phe Ser Thr
Tyr Asn1 5 38924DNAArtificial SequenceSynthetic 389attaggagta
gtagtaatta cata 243908PRTArtificial SequenceSynthetic 390Ile Arg
Ser Ser Ser Asn Tyr Ile1 5 39139DNAArtificial SequenceSynthetic
391gcgagagatg gcagcagttg gtacgactac tctgactac 3939213PRTArtificial
SequenceSynthetic 392Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser
Asp Tyr1 5 10 393321DNAArtificial SequenceSynthetic 393gacatccaga
tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gagtattagt agctggttgg cctggtatca acagatacca
120gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaaatgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
tcatcagcag cctgcagcct 240gatgattttg caacttatta ctgccaacag
tatattagtt attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321394107PRTArtificial SequenceSynthetic 394Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 39518DNAArtificial SequenceSynthetic 395cagagtatta gtagctgg
183966PRTArtificial SequenceSynthetic 396Gln Ser Ile Ser Ser Trp1 5
3979DNAArtificial SequenceSynthetic 397aaggcgtct 93983PRTArtificial
SequenceSynthetic 398Lys Ala Ser1 39927DNAArtificial
SequenceSynthetic 399caacagtata ttagttattc tcggacg
274009PRTArtificial SequenceSynthetic 400Gln Gln Tyr Ile Ser Tyr
Ser Arg Thr1 5 401360DNAArtificial SequenceSynthetic 401gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag agccgatgac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360402120PRTArtificial
SequenceSynthetic 402Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
403321DNAArtificial SequenceSynthetic 403gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca acagatacca 120gggaaagccc
ctaaactcct gatctataag gcgtctagtt tagaaaatgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca tcatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321404107PRTArtificial SequenceSynthetic 404Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 405360DNAArtificial SequenceSynthetic 405gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt acttataaca tgaactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccaaggaa ccctggtcac cgtctcctca 360406120PRTArtificial
SequenceSynthetic 406Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
407321DNAArtificial SequenceSynthetic 407gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321408107PRTArtificial SequenceSynthetic 408Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 409360DNAArtificial SequenceSynthetic 409gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag agccgatgac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360410120PRTArtificial
SequenceSynthetic 410Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
41124DNAArtificial SequenceSynthetic 411ggattcacct tcagtactta taac
244128PRTArtificial SequenceSynthetic 412Gly Phe Thr Phe Ser Thr
Tyr Asn1 5 41324DNAArtificial SequenceSynthetic 413attaggagta
gtagtaatta cata 244148PRTArtificial SequenceSynthetic 414Ile Arg
Ser Ser Ser Asn Tyr Ile1 5 41539DNAArtificial SequenceSynthetic
415gcgagagatg gcagcagttg gtacgactac tctgactac 3941613PRTArtificial
SequenceSynthetic 416Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser
Asp Tyr1 5 10 417321DNAArtificial SequenceSynthetic 417gacatccaga
tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gagtattagt agctggttgg cctggtatca acagatacca
120gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaaatgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
tcatcagcag cctgcagcct 240gatgattttg caacttatta ctgccaacag
tatattagtt attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321418107PRTArtificial SequenceSynthetic 418Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 41918DNAArtificial SequenceSynthetic 419cagagtatta gtagctgg
184206PRTArtificial SequenceSynthetic 420Gln Ser Ile Ser Ser Trp1 5
4219DNAArtificial SequenceSynthetic 421aaggcgtct 94223PRTArtificial
SequenceSynthetic 422Lys Ala Ser1 42327DNAArtificial
SequenceSynthetic 423caacagtata ttagttattc tcggacg
274249PRTArtificial SequenceSynthetic 424Gln Gln Tyr Ile Ser Tyr
Ser Arg Thr1 5 425360DNAArtificial SequenceSynthetic 425gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag agccgatgac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360426120PRTArtificial
SequenceSynthetic 426Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
427321DNAArtificial SequenceSynthetic 427gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca acagatacca 120gggaaagccc
ctaaactcct gatctataag gcgtctagtt tagaaaatgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca tcatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321428107PRTArtificial SequenceSynthetic 428Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 429360DNAArtificial SequenceSynthetic 429gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt acttataaca tgaactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccaaggaa ccctggtcac cgtctcctca 360430120PRTArtificial
SequenceSynthetic 430Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
431321DNAArtificial SequenceSynthetic 431gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321432107PRTArtificial SequenceSynthetic 432Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 433360DNAArtificial SequenceSynthetic 433gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagag ttcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360434120PRTArtificial
SequenceSynthetic 434Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
43524DNAArtificial SequenceSynthetic 435ggattcacct tcagtactta taac
244368PRTArtificial SequenceSynthetic 436Gly Phe Thr Phe Ser Thr
Tyr Asn1 5 43724DNAArtificial SequenceSynthetic 437attaggagta
gtagtaatta cata 244388PRTArtificial SequenceSynthetic 438Ile Arg
Ser Ser Ser Asn Tyr Ile1 5 43939DNAArtificial SequenceSynthetic
439gcgagagatg gcagcagttg gtacgactac tctgactac 3944013PRTArtificial
SequenceSynthetic 440Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser
Asp Tyr1 5 10 441321DNAArtificial SequenceSynthetic 441gacatccaga
tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gagtattagt agctggttgg cctggtatca acaggtacca
120gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaaatgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
tcatcagcag cctgcagcct 240gatgattttg caacttatta ctgccaacag
tatattagtt attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321442107PRTArtificial SequenceSynthetic 442Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Val Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 44318DNAArtificial SequenceSynthetic 443cagagtatta gtagctgg
184446PRTArtificial SequenceSynthetic 444Gln Ser Ile Ser Ser Trp1 5
4459DNAArtificial SequenceSynthetic 445aaggcgtct 94463PRTArtificial
SequenceSynthetic 446Lys Ala Ser1 44727DNAArtificial
SequenceSynthetic 447caacagtata ttagttattc tcggacg
274489PRTArtificial SequenceSynthetic 448Gln Gln Tyr Ile Ser Tyr
Ser Arg Thr1 5 449360DNAArtificial SequenceSynthetic 449gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagag ttcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360450120PRTArtificial
SequenceSynthetic 450Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
451321DNAArtificial SequenceSynthetic 451gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca acaggtacca 120gggaaagccc
ctaaactcct gatctataag gcgtctagtt tagaaaatgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca tcatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321452107PRTArtificial SequenceSynthetic 452Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Val Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 453360DNAArtificial SequenceSynthetic 453gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt acttataaca tgaactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360454120PRTArtificial
SequenceSynthetic 454Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
455321DNAArtificial SequenceSynthetic 455gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca gcagaaacca 120gggaaagccc
ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321456107PRTArtificial SequenceSynthetic 456Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 457360DNAArtificial SequenceSynthetic 457gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag agccgatgac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360458120PRTArtificial
SequenceSynthetic 458Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
45924DNAArtificial SequenceSynthetic 459ggattcacct tcagtactta taac
244608PRTArtificial SequenceSynthetic 460Gly Phe Thr Phe Ser Thr
Tyr Asn1 5 46124DNAArtificial SequenceSynthetic 461attaggagta
gtagtaatta cata 244628PRTArtificial SequenceSynthetic 462Ile Arg
Ser Ser Ser Asn Tyr Ile1 5 46339DNAArtificial SequenceSynthetic
463gcgagagatg gcagcagttg gtacgactac tctgactac 3946413PRTArtificial
SequenceSynthetic 464Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser
Asp Tyr1 5 10 465321DNAArtificial SequenceSynthetic 465gacatccaga
tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gagtattagt agctggttgg cctggtatca acagatacca
120gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaaatgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
tcatcagcag cctgcagcct 240gatgattttg caacttatta ctgccaacag
tatattagtt attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321466107PRTArtificial SequenceSynthetic 466Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 46718DNAArtificial SequenceSynthetic 467cagagtatta gtagctgg
184686PRTArtificial SequenceSynthetic 468Gln Ser Ile Ser Ser Trp1 5
4699DNAArtificial SequenceSynthetic 469aaggcgtct 94703PRTArtificial
SequenceSynthetic 470Lys Ala Ser1 47127DNAArtificial
SequenceSynthetic 471caacagtata ttagttattc tcggacg
274729PRTArtificial SequenceSynthetic 472Gln Gln Tyr Ile Ser Tyr
Ser Arg Thr1 5 473360DNAArtificial SequenceSynthetic 473gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc 60tcctgtacag
cctctggatt caccttcagt acttataaca tgaattgggt ccgccaggct
120ccagggaagg gactggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ttcactgtat 240ctgcaaatga acagcctgag agccgatgac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccagggaa ccctggtcac cgtctcctca 360474120PRTArtificial
SequenceSynthetic 474Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
475321DNAArtificial SequenceSynthetic 475gacatccaga tgacccagtc
tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca
gagtattagt agctggttgg cctggtatca acagatacca 120gggaaagccc
ctaaactcct gatctataag gcgtctagtt tagaaaatgg ggtcccatca
180aggttcagcg gcagtggatc tgggacagaa ttcactctca tcatcagcag
cctgcagcct 240gatgattttg caacttatta ctgccaacag tatattagtt
attctcggac gttcggccaa 300gggaccaagg tggaaatcaa a
321476107PRTArtificial SequenceSynthetic 476Asp Ile Gln Met Thr Gln
Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala
Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Ser Leu Gln
Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser
Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 477360DNAArtificial SequenceSynthetic 477gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt acttataaca tgaactgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcatcc attaggagta gtagtaatta
catatactac 180gcagactcag tgaagggccg attcaccatc tccagagaca
acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggctgtgt attactgtgc gagagatggc 300agcagttggt acgactactc
tgactactgg ggccaaggaa ccctggtcac cgtctcctca 360478120PRTArtificial
SequenceSynthetic 478Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met Asn Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Ser
Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Asp Gly Ser Ser Trp Tyr Asp Tyr Ser Asp Tyr Trp Gly Gln
100
105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 479321DNAArtificial
SequenceSynthetic 479gacatccaga tgacccagtc tccttccacc ctgtctgcat
ctgtaggaga cagagtcacc 60atcacttgcc gggccagtca gagtattagt agctggttgg
cctggtatca gcagaaacca 120gggaaagccc ctaagctcct gatctataag
gcgtctagtt tagaaagtgg ggtcccatca 180aggttcagcg gcagtggatc
tgggacagaa ttcactctca ccatcagcag cctgcagcct 240gatgattttg
caacttatta ctgccaacag tatattagtt attctcggac gttcggccaa
300gggaccaagg tggaaatcaa a 321480107PRTArtificial SequenceSynthetic
480Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1
5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser
Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Tyr Ile Ser Tyr Ser Arg 85 90 95 Thr Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys 100 105 481354DNAArtificial
SequenceSynthetic 481gaggtgcaac tagtggagtc tgggggaggc ttggtacagc
ctggggggtc cctgagactc 60tcctgtgtag tctctggatt caccttcggt gactacgaca
tgcactgggt ccgtcaagct 120acaggaagag gtctggagtg ggtctcaggt
attgctcctg ctggtgacac atcctataca 180ggctccgtga agggccgatt
caccatctcc agagagaatg ccaagaactc cttgcatctt 240caaatgaaca
gcctgacaac cggggacacg gctatatatt attgtgctag agaggatata
300gcagtgcctg gttttgatta ctggggccag ggaaccctgg tcaccgtctc ctca
354482118PRTArtificial SequenceSynthetic 482Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Val Val Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Asp Met
His Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Val 35 40 45
Ser Gly Ile Ala Pro Ala Gly Asp Thr Ser Tyr Thr Gly Ser Val Lys 50
55 60 Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu His
Leu65 70 75 80 Gln Met Asn Ser Leu Thr Thr Gly Asp Thr Ala Ile Tyr
Tyr Cys Ala 85 90 95 Arg Glu Asp Ile Ala Val Pro Gly Phe Asp Tyr
Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115
48324DNAArtificial SequenceSynthetic 483ggattcacct tcggtgacta cgac
244848PRTArtificial SequenceSynthetic 484Gly Phe Thr Phe Gly Asp
Tyr Asp1 5 48521DNAArtificial SequenceSynthetic 485attgctcctg
ctggtgacac a 214867PRTArtificial SequenceSynthetic 486Ile Ala Pro
Ala Gly Asp Thr1 5 48736DNAArtificial SequenceSynthetic
487gctagagagg atatagcagt gcctggtttt gattac 3648812PRTArtificial
SequenceSynthetic 488Ala Arg Glu Asp Ile Ala Val Pro Gly Phe Asp
Tyr1 5 10 489324DNAArtificial SequenceSynthetic 489gaaatagtga
tgacgcagtc tccagccacc ctgtctgtgt ctccagggga acgaggcacc 60ctctcctgca
gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct
120ggccaggctc ccagactcct catctatggt gcatccacga gggccactgg
cttcccagcc 180aggttcagtg gcagtgggtc tgggacagag ttcactctca
ccatcagcag cctgcagtct 240gaagattttg cagtttatta ctgtcagcag
tataataagt ggcctccgtt cactttcggc 300cctgggacca aagtggattt caaa
324490108PRTArtificial SequenceSynthetic 490Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15 Glu Arg Gly Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Phe Pro Ala Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys
Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Phe
Lys 100 105 49118DNAArtificial SequenceSynthetic 491cagagtgtta
gcagcaac 184926PRTArtificial SequenceSynthetic 492Gln Ser Val Ser
Ser Asn1 5 4939DNAArtificial SequenceSynthetic 493ggtgcatcc
94943PRTArtificial SequenceSynthetic 494Gly Ala Ser1
49530DNAArtificial SequenceSynthetic 495cagcagtata ataagtggcc
tccgttcact 3049610PRTArtificial SequenceSynthetic 496Gln Gln Tyr
Asn Lys Trp Pro Pro Phe Thr1 5 10 497354DNAArtificial
SequenceSynthetic 497gaggtgcaac tagtggagtc tgggggaggc ttggtacagc
ctggggggtc cctgagactc 60tcctgtgtag tctctggatt caccttcggt gactacgaca
tgcactgggt ccgtcaagct 120acaggaagag gtctggagtg ggtctcaggt
attgctcctg ctggtgacac atcctataca 180ggctccgtga agggccgatt
caccatctcc agagagaatg ccaagaactc cttgcatctt 240caaatgaaca
gcctgacaac cggggacacg gctatatatt attgtgctag agaggatata
300gcagtgcctg gttttgatta ctggggccag ggaaccctgg tcaccgtctc ctca
354498118PRTArtificial SequenceSynthetic 498Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Val Val Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Asp Met
His Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Val 35 40 45
Ser Gly Ile Ala Pro Ala Gly Asp Thr Ser Tyr Thr Gly Ser Val Lys 50
55 60 Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu His
Leu65 70 75 80 Gln Met Asn Ser Leu Thr Thr Gly Asp Thr Ala Ile Tyr
Tyr Cys Ala 85 90 95 Arg Glu Asp Ile Ala Val Pro Gly Phe Asp Tyr
Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115
499324DNAArtificial SequenceSynthetic 499gaaatagtga tgacgcagtc
tccagccacc ctgtctgtgt ctccagggga acgaggcacc 60ctctcctgca gggccagtca
gagtgttagc agcaacttag cctggtacca gcagaaacct 120ggccaggctc
ccagactcct catctatggt gcatccacga gggccactgg cttcccagcc
180aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag
cctgcagtct 240gaagattttg cagtttatta ctgtcagcag tataataagt
ggcctccgtt cactttcggc 300cctgggacca aagtggatat caaa
324500108PRTArtificial SequenceSynthetic 500Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15 Glu Arg Gly Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Phe Pro Ala Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys
Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
Lys 100 105 501354DNAArtificial SequenceSynthetic 501gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcggt gactacgaca tgcactgggt ccgccaagct
120acaggaaaag gtctggagtg ggtctcagct attgctcctg ctggtgacac
atactatcca 180ggctccgtga agggccgatt caccatctcc agagaaaatg
ccaagaactc cttgtatctt 240caaatgaaca gcctgagagc cggggacacg
gctgtgtatt actgtgctag agaggatata 300gcagtgcctg gttttgatta
ctggggccaa ggaaccctgg tcaccgtctc ctca 354502118PRTArtificial
SequenceSynthetic 502Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Asp Met His Trp Val Arg Gln
Ala Thr Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ala Pro
Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe
Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln
Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Asp Ile Ala Val Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110 Leu Val Thr Val Ser Ser 115 503324DNAArtificial
SequenceSynthetic 503gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt
ctccagggga aagagccacc 60ctctcctgca gggccagtca gagtgttagc agcaacttag
cctggtacca gcagaaacct 120ggccaggctc ccaggctcct catctatggt
gcatccacca gggccactgg tatcccagcc 180aggttcagtg gcagtgggtc
tgggacagag ttcactctca ccatcagcag cctgcagtct 240gaagattttg
cagtttatta ctgtcagcag tataataagt ggcctccgtt cactttcggc
300cctgggacca aagtggatat caaa 324504108PRTArtificial
SequenceSynthetic 504Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu
Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr
Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser65 70 75 80 Glu
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys Trp Pro Pro 85 90
95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105
505378DNAArtificial SequenceSynthetic 505caaattctgc tggtgcaatc
tggacctgag gtgaaggagc ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta
cacctttacc aactacgcta tcagctgggt gcgacaggtc 120cctggacaag
ggcttgagtg gatgggatgg gtcagcgctt acaatggtca cacaaactat
180gcacatgaag tccagggcag agtcaccatg accacagaca catccacgac
cacagcctac 240atggagctga ggagcctgag atctgacgac acggccatgt
attactgtgc gagagggggt 300gtagtcgtgc cagttgctcc ccacttctac
aacggtatgg acgtctgggg ccaagggacc 360acggtcaccg tctcctca
378506126PRTArtificial SequenceSynthetic 506Gln Ile Leu Leu Val Gln
Ser Gly Pro Glu Val Lys Glu Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ala Ile
Ser Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Val Ser Ala Tyr Asn Gly His Thr Asn Tyr Ala His Glu Val 50
55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Met
Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Val Val Pro Val Ala Pro
His Phe Tyr Asn Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr
Val Thr Val Ser Ser 115 120 125 50724DNAArtificial
SequenceSynthetic 507ggttacacct ttaccaacta cgct 245088PRTArtificial
SequenceSynthetic 508Gly Tyr Thr Phe Thr Asn Tyr Ala1 5
50924DNAArtificial SequenceSynthetic 509gtcagcgctt acaatggtca caca
245108PRTArtificial SequenceSynthetic 510Val Ser Ala Tyr Asn Gly
His Thr1 5 51157DNAArtificial SequenceSynthetic 511gcgagagggg
gtgtagtcgt gccagttgct ccccacttct acaacggtat ggacgtc
5751219PRTArtificial SequenceSynthetic 512Ala Arg Gly Gly Val Val
Val Pro Val Ala Pro His Phe Tyr Asn Gly1 5 10 15 Met Asp
Val513336DNAArtificial SequenceSynthetic 513gatattgtga tgactcagtt
tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca ggtctagtca
gagcctcctg catattaatg aatacaacta tttggattgg 120tacctaaaga
agccagggca gtctccacag ctcctgatct atttgggttt taatcgggcc
180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac
actgaaaatc 240agcagagtgg aggctgagga tgttggggtc tattactgca
tgcaagctct tcaaactccg 300tggacgttag gccaagggac caaggtggaa atcaaa
336514112PRTArtificial SequenceSynthetic 514Asp Ile Val Met Thr Gln
Phe Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ile 20 25 30 Asn Glu
Tyr Asn Tyr Leu Asp Trp Tyr Leu Lys Lys Pro Gly Gln Ser 35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr Leu Gly Gln Gly Thr
Lys Val Glu Ile Lys 100 105 110 51533DNAArtificial
SequenceSynthetic 515cagagcctcc tgcatattaa tgaatacaac tat
3351611PRTArtificial SequenceSynthetic 516Gln Ser Leu Leu His Ile
Asn Glu Tyr Asn Tyr1 5 10 5179DNAArtificial SequenceSynthetic
517ttgggtttt 95183PRTArtificial SequenceSynthetic 518Leu Gly Phe1
51927DNAArtificial SequenceSynthetic 519atgcaagctc ttcaaactcc
gtggacg 275209PRTArtificial SequenceSynthetic 520Met Gln Ala Leu
Gln Thr Pro Trp Thr1 5 521378DNAArtificial SequenceSynthetic
521caggttcagc tggtgcagtc tggacctgag gtgaaggagc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactacgcta tcagctgggt
gcgacaggtc 120cctggacaag ggcttgagtg gatgggatgg gtcagcgctt
acaatggtca cacaaactat 180gcacatgaag tccagggcag agtcaccatg
accacagaca catccacgac cacagcctac 240atggagctga ggagcctgag
atctgacgac acggccatgt attactgtgc gagagggggt 300gtagtcgtgc
cagttgctcc ccacttctac aacggtatgg acgtctgggg ccaagggacc
360acggtcaccg tctcctca 378522126PRTArtificial SequenceSynthetic
522Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Glu Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Val Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Val Ser Ala Tyr Asn Gly His Thr Asn
Tyr Ala His Glu Val 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Thr Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Ser Asp Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val
Val Val Pro Val Ala Pro His Phe Tyr Asn Gly 100 105 110 Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
523336DNAArtificial SequenceSynthetic 523gatattgtga tgactcagtc
tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca ggtctagtca
gagcctcctg catattaatg aatacaacta tttggattgg 120tacctaaaga
agccagggca gtctccacag ctcctgatct atttgggttt taatcgggcc
180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac
actgaaaatc 240agcagagtgg aggctgagga tgttggggtc tattactgca
tgcaagctct tcaaactccg 300tggacgttag gccaagggac caaggtggaa atcaaa
336524112PRTArtificial SequenceSynthetic 524Asp Ile Val Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ile 20 25 30 Asn Glu
Tyr Asn Tyr Leu Asp Trp Tyr Leu Lys Lys Pro Gly Gln Ser 35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro
50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr
Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr Leu Gly Gln Gly
Thr Lys Val Glu Ile Lys 100 105 110 525378DNAArtificial
SequenceSynthetic 525caggttcagc tggtgcagtc tggagctgag gtgaagaagc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactacgcta
tcagctgggt gcgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
gtcagcgctt acaatggtca cacaaactat 180gcacagaagc tccagggcag
agtcaccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccgtgt attactgtgc gagagggggt
300gtagtcgtgc cagttgctcc ccacttctac aacggtatgg acgtctgggg
gcaagggacc 360acggtcaccg tctcctca 378526126PRTArtificial
SequenceSynthetic 526Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Val Ser Ala
Tyr Asn Gly His Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg
Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Gly Gly Val Val Val Pro Val Ala Pro His Phe Tyr Asn Gly
100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125 527336DNAArtificial SequenceSynthetic 527gatattgtga
tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca
ggtctagtca gagcctcctg catattaatg aatacaacta tttggattgg
120tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc
taatcgggcc 180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca
cagattttac actgaaaatc 240agcagagtgg aggctgagga tgttggggtt
tattactgca tgcaagctct tcaaactccg 300tggacgttcg gccaagggac
caaggtggaa atcaaa 336528112PRTArtificial SequenceSynthetic 528Asp
Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10
15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ile
20 25 30 Asn Glu Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly
Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110
529351DNAArtificial SequenceSynthetic 529gaggtgcagc tggtggagtc
tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag cctctggatt
caccctaagt agctacgaca tgcactgggt ccgccaagca 120acaggaaaag
gtctggagtg ggtctcagct attggcagta ctggtgacac atactataca
180ggctccgtga tgggccgatt caccatctcc agagacgctg ccaaaaactc
cttctatctt 240gaaatgaaca gcctgagagt cggggacacg gctgtatatt
actgtgcaag agagggaata 300agaacaccct atgattattg gggccaggga
gcccgggtca ccgtctcctc a 351530117PRTArtificial SequenceSynthetic
530Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser
Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr
Thr Gly Ser Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ala
Ala Lys Asn Ser Phe Tyr Leu65 70 75 80 Glu Met Asn Ser Leu Arg Val
Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Ile Arg
Thr Pro Tyr Asp Tyr Trp Gly Gln Gly Ala Arg 100 105 110 Val Thr Val
Ser Ser 115 53124DNAArtificial SequenceSynthetic 531ggattcaccc
taagtagcta cgac 245328PRTArtificial SequenceSynthetic 532Gly Phe
Thr Leu Ser Ser Tyr Asp1 5 53321DNAArtificial SequenceSynthetic
533attggcagta ctggtgacac a 215347PRTArtificial SequenceSynthetic
534Ile Gly Ser Thr Gly Asp Thr1 5 53533DNAArtificial
SequenceSynthetic 535gcaagagagg gaataagaac accctatgat tat
3353611PRTArtificial SequenceSynthetic 536Ala Arg Glu Gly Ile Arg
Thr Pro Tyr Asp Tyr1 5 10 537324DNAArtificial SequenceSynthetic
537gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga
aagagccacc 60ctctcctgca gggccagtca gagtgttagc agcaatgtag cctggtacca
gcagaaacct 120ggccaggctc ccaggctcct catctatggt gcatccacca
gggccactgg tatcccagcc 180aggttcagtg gcagtgggtc tgggacagaa
ttcactctca ccatcagcag cctgcagtct 240gaagattttg cagtttatta
ctgtcagcag tataataatt ggcctccatt cactttcggc 300cctgggacca
aagtggatat caaa 324538108PRTArtificial SequenceSynthetic 538Glu Ile
Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20
25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
Ser Ser Leu Gln Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr Asn Asn Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr
Lys Val Asp Ile Lys 100 105 53918DNAArtificial SequenceSynthetic
539cagagtgtta gcagcaat 185406PRTArtificial SequenceSynthetic 540Gln
Ser Val Ser Ser Asn1 5 5419DNAArtificial SequenceSynthetic
541ggtgcatcc 95423PRTArtificial SequenceSynthetic 542Gly Ala Ser1
54330DNAArtificial SequenceSynthetic 543cagcagtata ataattggcc
tccattcact 3054410PRTArtificial SequenceSynthetic 544Gln Gln Tyr
Asn Asn Trp Pro Pro Phe Thr1 5 10 545351DNAArtificial
SequenceSynthetic 545gaggtgcagc tggtggagtc tgggggaggc ttggtacagc
ctggggggtc cctgagactc 60tcctgtgcag cctctggatt caccctaagt agctacgaca
tgcactgggt ccgccaagca 120acaggaaaag gtctggagtg ggtctcagct
attggcagta ctggtgacac atactataca 180ggctccgtga tgggccgatt
caccatctcc agagacgctg ccaaaaactc cttctatctt 240gaaatgaaca
gcctgagagt cggggacacg gctgtatatt actgtgcaag agagggaata
300agaacaccct atgattattg gggccaggga accctggtca ccgtctcctc a
351546117PRTArtificial SequenceSynthetic 546Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met
His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr Thr Gly Ser Val Met 50
55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Ser Phe Tyr
Leu65 70 75 80 Glu Met Asn Ser Leu Arg Val Gly Asp Thr Ala Val Tyr
Tyr Cys Ala 85 90 95 Arg Glu Gly Ile Arg Thr Pro Tyr Asp Tyr Trp
Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
547324DNAArtificial SequenceSynthetic 547gaaatagtga tgacgcagtc
tccagccacc ctgtctgtgt ctccagggga aagagccacc 60ctctcctgca gggccagtca
gagtgttagc agcaatgtag cctggtacca gcagaaacct 120ggccaggctc
ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc
180aggttcagtg gcagtgggtc tgggacagaa ttcactctca ccatcagcag
cctgcagtct 240gaagattttg cagtttatta ctgtcagcag tataataatt
ggcctccatt cactttcggc 300cctgggacca aagtggatat caaa
324548108PRTArtificial SequenceSynthetic 548Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Val Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn
Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
Lys 100 105 549351DNAArtificial SequenceSynthetic 549gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccctaagt agctacgaca tgcactgggt ccgccaagct
120acaggaaaag gtctggagtg ggtctcagct attggcagta ctggtgacac
atactatcca 180ggctccgtga agggccgatt caccatctcc agagaaaatg
ccaagaactc cttgtatctt 240caaatgaaca gcctgagagc cggggacacg
gctgtgtatt actgtgcaag agagggaata 300agaacaccct atgattattg
gggccaagga accctggtca ccgtctcctc a 351550117PRTArtificial
SequenceSynthetic 550Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln
Ala Thr Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser
Thr Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe
Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln
Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Gly Ile Arg Thr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110 Val Thr Val Ser Ser 115 551324DNAArtificial
SequenceSynthetic 551gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt
ctccagggga aagagccacc 60ctctcctgca gggccagtca gagtgttagc agcaatttag
cctggtacca gcagaaacct 120ggccaggctc ccaggctcct catctatggt
gcatccacca gggccactgg tatcccagcc 180aggttcagtg gcagtgggtc
tgggacagag ttcactctca ccatcagcag cctgcagtct 240gaagattttg
cagtttatta ctgtcagcag tataataatt ggcctccatt cactttcggc
300cctgggacca aagtggatat caaa 324552108PRTArtificial
SequenceSynthetic 552Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu
Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr
Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser65 70 75 80 Glu
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 85 90
95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105
553351DNAArtificial SequenceSynthetic 553gaggtgcagc tggtggagtc
tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag cctctggatt
caccctaagt agctacgaca tgcactgggt ccgccaagca 120acaggaaaag
gtctggagtg ggtctcagct attggcagta ctggtgacac atactataca
180ggctccgtga tgggccgatt caccatctcc agagacgctg ccaaaaactc
cttctatctt 240gaaatgaaca gcctgagagt cggggacacg gctgtatatt
actgtgcaag agagggaata 300agaacaccct atgattattg gggccaggga
gcccgggtca ccgtctcctc a 351554117PRTArtificial SequenceSynthetic
554Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser
Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr
Thr Gly Ser Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ala
Ala Lys Asn Ser Phe Tyr Leu65 70 75 80 Glu Met Asn Ser Leu Arg Val
Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Ile Arg
Thr Pro Tyr Asp Tyr Trp Gly Gln Gly Ala Arg 100 105 110 Val Thr Val
Ser Ser 115 55524DNAArtificial SequenceSynthetic 555ggattcaccc
taagtagcta cgac 245568PRTArtificial SequenceSynthetic 556Gly Phe
Thr Leu Ser Ser Tyr Asp1 5 55721DNAArtificial SequenceSynthetic
557attggcagta ctggtgacac a 215587PRTArtificial SequenceSynthetic
558Ile Gly Ser Thr Gly Asp Thr1 5 55933DNAArtificial
SequenceSynthetic 559gcaagagagg gaataagaac accctatgat tat
3356011PRTArtificial SequenceSynthetic 560Ala Arg Glu Gly Ile Arg
Thr Pro Tyr Asp Tyr1 5 10 561324DNAArtificial SequenceSynthetic
561gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga
aagagccacc 60ctctcctgca gggccagtca gagtgttagc agcaatgtag cctggtacca
gcagaaacct 120ggccaggctc ccaggctcct catctatggt gcatccacca
gggccactgg tatcccagcc 180aggttcagtg gcagtgggtc tgggacagaa
ttcactctca ccatcagcag cctgcagtct 240gaagattttg cagtttatta
ctgtcagcag tataataatt ggcctccatt cactttcggc 300cctgggacca
aagtggatat caaa 324562108PRTArtificial SequenceSynthetic 562Glu Ile
Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20
25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
Ser Ser Leu Gln Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr Asn Asn Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr
Lys Val Asp Ile Lys 100 105 56318DNAArtificial SequenceSynthetic
563cagagtgtta gcagcaat 185646PRTArtificial SequenceSynthetic 564Gln
Ser Val Ser Ser Asn1 5 5659DNAArtificial SequenceSynthetic
565ggtgcatcc 95663PRTArtificial SequenceSynthetic 566Gly Ala Ser1
56730DNAArtificial SequenceSynthetic 567cagcagtata ataattggcc
tccattcact 3056810PRTArtificial SequenceSynthetic 568Gln Gln Tyr
Asn Asn Trp Pro Pro Phe Thr1 5 10 569351DNAArtificial
SequenceSynthetic 569gaggtgcagc tggtggagtc tgggggaggc ttggtacagc
ctggggggtc cctgagactc 60tcctgtgcag cctctggatt caccctaagt agctacgaca
tgcactgggt ccgccaagca 120acaggaaaag gtctggagtg ggtctcagct
attggcagta ctggtgacac atactataca 180ggctccgtga tgggccgatt
caccatctcc agagacgctg ccaaaaactc cttctatctt 240gaaatgaaca
gcctgagagt cggggacacg gctgtatatt actgtgcaag agagggaata
300agaacaccct atgattattg gggccaggga accctggtca ccgtctcctc a
351570117PRTArtificial SequenceSynthetic 570Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met
His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45 Ser Ala Ile Gly Ser Thr Gly Asp Thr Tyr Tyr Thr Gly Ser
Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn
Ser Phe Tyr Leu65 70 75 80 Glu Met Asn Ser Leu Arg Val Gly Asp Thr
Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Ile Arg Thr Pro Tyr
Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
571324DNAArtificial SequenceSynthetic 571gaaatagtga tgacgcagtc
tccagccacc ctgtctgtgt ctccagggga aagagccacc 60ctctcctgca gggccagtca
gagtgttagc agcaatgtag cctggtacca gcagaaacct 120ggccaggctc
ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc
180aggttcagtg gcagtgggtc tgggacagaa ttcactctca ccatcagcag
cctgcagtct 240gaagattttg cagtttatta ctgtcagcag tataataatt
ggcctccatt cactttcggc 300cctgggacca aagtggatat caaa
324572108PRTArtificial SequenceSynthetic 572Glu Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Val Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Ser65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn
Trp Pro Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
Lys 100 105 573351DNAArtificial SequenceSynthetic 573gaggtgcagc
tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt caccctaagt agctacgaca tgcactgggt ccgccaagct
120acaggaaaag gtctggagtg ggtctcagct attggcagta ctggtgacac
atactatcca 180ggctccgtga agggccgatt caccatctcc agagaaaatg
ccaagaactc cttgtatctt 240caaatgaaca gcctgagagc cggggacacg
gctgtgtatt actgtgcaag agagggaata 300agaacaccct atgattattg
gggccaagga accctggtca ccgtctcctc a 351574117PRTArtificial
SequenceSynthetic 574Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln
Ala Thr Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Ser
Thr Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 50 55 60 Gly Arg Phe
Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu65 70 75 80 Gln
Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 85 90
95 Arg Glu Gly Ile Arg Thr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110 Val Thr Val Ser Ser 115 575324DNAArtificial
SequenceSynthetic 575gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt
ctccagggga aagagccacc 60ctctcctgca gggccagtca gagtgttagc agcaatttag
cctggtacca gcagaaacct 120ggccaggctc ccaggctcct catctatggt
gcatccacca gggccactgg tatcccagcc 180aggttcagtg gcagtgggtc
tgggacagag ttcactctca ccatcagcag cctgcagtct 240gaagattttg
cagtttatta ctgtcagcag tataataatt ggcctccatt cactttcggc
300cctgggacca aagtggatat caaa 324576108PRTArtificial
SequenceSynthetic 576Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu
Ser Val Ser Pro Gly1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr
Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser65 70 75 80 Glu
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 85 90
95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105
577363DNAArtificial SequenceSynthetic 577gaagtgcagc tggtggagtc
tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60tcctgtgcag cctctggatt
cacctttgat gattatgcca tgcactgggt ccggcaagct 120ccagggaagg
gcctggagtg ggtctcaggt attaattgga acagtggtag cataggctat
180gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagca
ctccctgtat 240ctgcaaatga acagtctgag acctgaggac acggccttgt
attactgtgt aaaagaggtg 300actacgggat actactacgg tatggacgtc
tggggccaag ggaccacggt caccgtctcc 360tca 363578121PRTArtificial
SequenceSynthetic 578Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp
Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ala Lys His Ser Leu Tyr65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90
95 Val Lys Glu Val Thr Thr Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120
57924DNAArtificial SequenceSynthetic 579ggattcacct ttgatgatta tgcc
245808PRTArtificial SequenceSynthetic 580Gly Phe Thr Phe Asp Asp
Tyr Ala1 5 58124DNAArtificial SequenceSynthetic 581attaattgga
acagtggtag cata 245828PRTArtificial SequenceSynthetic 582Ile Asn
Trp Asn Ser Gly Ser Ile1 5 58342DNAArtificial SequenceSynthetic
583gtaaaagagg tgactacggg atactactac ggtatggacg tc
4258414PRTArtificial SequenceSynthetic 584Val Lys Glu Val Thr Thr
Gly Tyr Tyr Tyr Gly Met Asp Val1 5 10 585321DNAArtificial
SequenceSynthetic 585gacatccagt tgacccagtc tccatccttc ctgtctgcat
ctgtaggaga cagagtcacc 60atcacttgct gggccagtca gggcattagc agttatttag
cctggtatca gaaaaaacca 120gggaaagccc ctaacctcct gatctatgat
gcatccactt tgcaaagtgg ggtcccatca 180aggttcagcg gcagtggatc
tgggacagaa ttcactctca cactcagcag cctgcagcct 240gaagattttg
caacttatta ctgtcaacag cttaatattt acccattcac tttcggccct
300gggaccaaag tggatatcaa a 321586107PRTArtificial SequenceSynthetic
586Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1
5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Ser
Tyr 20 25 30 Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Asn
Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu
Thr Leu Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Leu Asn Ile Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly
Thr Lys Val Asp Ile Lys 100 105 58718DNAArtificial
SequenceSynthetic 587cagggcatta gcagttat 185886PRTArtificial
SequenceSynthetic 588Gln Gly Ile Ser Ser Tyr1 5 5899DNAArtificial
SequenceSynthetic 589gatgcatcc 95903PRTArtificial SequenceSynthetic
590Asp Ala Ser1 59127DNAArtificial SequenceSynthetic 591caacagctta
atatttaccc attcact 275929PRTArtificial SequenceSynthetic 592Gln Gln
Leu Asn Ile Tyr Pro Phe Thr1 5 593363DNAArtificial
SequenceSynthetic 593gaagtgcagc tggtggagtc tgggggaggc ttggtacagc
ctggcaggtc cctgagactc 60tcctgtgcag cctctggatt cacctttgat gattatgcca
tgcactgggt ccggcaagct 120ccagggaagg gcctggagtg ggtctcaggt
attaattgga acagtggtag cataggctat 180gcggactctg tgaagggccg
attcaccatc tccagagaca acgccaagca ctccctgtat 240ctgcaaatga
acagtctgag acctgaggac acggccttgt attactgtgt aaaagaggtg
300actacgggat actactacgg tatggacgtc tggggccaag ggaccacggt
caccgtctcc 360tca 363594121PRTArtificial SequenceSynthetic 594Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg1 5 10
15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Ser Gly Ser Ile Gly Tyr
Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ala Lys His Ser Leu Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro
Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Glu Val Thr Thr
Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr
Val Thr Val Ser Ser 115 120 595321DNAArtificial SequenceSynthetic
595gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga
cagagtcacc 60atcacttgct gggccagtca gggcattagc agttatttag cctggtatca
gaaaaaacca 120gggaaagccc ctaacctcct gatctatgat gcatccactt
tgcaaagtgg ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa
ttcactctca cactcagcag cctgcagcct 240gaagattttg caacttatta
ctgtcaacag cttaatattt acccattcac tttcggccct 300gggaccaaag
tggatatcaa a 321596107PRTArtificial SequenceSynthetic 596Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15
Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Ser Tyr 20
25 30 Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Asn Leu Leu
Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Leu
Ser Ser Leu Gln Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
Gln Leu Asn Ile Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys
Val Asp Ile Lys 100 105 597363DNAArtificial SequenceSynthetic
597gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc
cctgagactc 60tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt
ccggcaagct 120ccagggaagg gcctggagtg ggtctcaggt attaattgga
acagtggtag cataggctat 180gcggactctg tgaagggccg attcaccatc
tccagagaca acgccaagaa ctccctgtat 240ctgcaaatga acagtctgag
agctgaggac acggccttgt attactgtgt aaaagaggtg 300actacgggat
actactacgg tatggacgtc tgggggcaag ggaccacggt caccgtctcc 360tca
363598121PRTArtificial SequenceSynthetic 598Glu Val Gln Leu Val Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Arg1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Gly Ile Asn Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu
Tyr Tyr Cys 85 90 95 Val Lys Glu Val Thr Thr Gly Tyr Tyr Tyr Gly
Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 599321DNAArtificial SequenceSynthetic 599gacatccagt
tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60atcacttgcc
gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca
120gggaaagccc ctaagctcct gatctatgat gcatccactt tgcaaagtgg
ggtcccatca 180aggttcagcg gcagtggatc tgggacagaa ttcactctca
caatcagcag cctgcagcct 240gaagattttg caacttatta ctgtcaacag
cttaatattt acccattcac tttcggccct 300gggaccaaag tggatatcaa a
321600107PRTArtificial SequenceSynthetic 600Asp Ile Gln Leu Thr Gln
Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15 Asp Arg Val Thr
Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ile
Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 601366DNAArtificial SequenceSynthetic 601gaggtgcagt
tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacgtttagt agctatgcca tgaactgggt ccgccaggct
120ccagggaagg ggctggattg ggtctcaggt atcagtggta atggtggtag
cacctactac 180gcagactccg tgaagggccg gttcaccatc tccagagaca
tttccaagaa cacgctgtat 240gtgcaaatgc acagcctgag agtcgaggac
acggccgttt actactgtgc gaaagcccgt 300tattacgatt tttggggggg
gaatttcgat ctctggggcc gtggcaccca ggtcactgtc 360tcctca
366602122PRTArtificial SequenceSynthetic 602Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45
Ser Gly Ile Ser Gly Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu
Tyr65 70 75 80 Val Gln Met His Ser Leu Arg Val Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Ala Arg Tyr Tyr Asp Phe Trp Gly Gly
Asn Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Gln Val Thr Val Ser
Ser 115 120 60324DNAArtificial SequenceSynthetic 603ggattcacgt
ttagtagcta tgcc 246048PRTArtificial SequenceSynthetic 604Gly Phe
Thr Phe Ser Ser Tyr Ala1 5 60524DNAArtificial SequenceSynthetic
605atcagtggta atggtggtag cacc 246068PRTArtificial SequenceSynthetic
606Ile Ser Gly Asn Gly Gly Ser Thr1 5 60745DNAArtificial
SequenceSynthetic 607gcgaaagccc gttattacga tttttggggg gggaatttcg
atctc 4560815PRTArtificial SequenceSynthetic 608Ala Lys Ala Arg Tyr
Tyr Asp Phe Trp Gly Gly Asn Phe Asp Leu1 5 10 15
609324DNAArtificial SequenceSynthetic 609gaaattgtgt tgacgcagtc
tccaggcacc ctgtctttgt ctccagggga aagagccacc 60ctctcctgca gggccagtca
gagtgttagc atcaggtact tagcctggta tcagcagaaa 120cctggccagg
ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca
180gacaggttca gtgtcagtgt gtctgggaca gacttcactc tcaccatcac
tagactggag 240cctgaagatt ttgcagtcta ttactgtcag caatatggta
gttcaccgct cactttcggc 300ggagggacca aggtggagat caaa
324610108PRTArtificial SequenceSynthetic 610Glu Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Arg 20 25 30 Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60
Val Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu65
70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser
Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 61121DNAArtificial SequenceSynthetic 611cagagtgtta
gcatcaggta c 216127PRTArtificial SequenceSynthetic 612Gln Ser Val
Ser Ile Arg Tyr1 5 6139DNAArtificial SequenceSynthetic 613ggtgcatcc
96143PRTArtificial SequenceSynthetic 614Gly Ala Ser1
61527DNAArtificial SequenceSynthetic 615cagcaatatg gtagttcacc
gctcact 276169PRTArtificial SequenceSynthetic 616Gln Gln Tyr Gly
Ser Ser Pro Leu Thr1 5 617366DNAArtificial SequenceSynthetic
617gaggtgcagt tgttggagtc tgggggaggc ttggtacagc ctggggggtc
cctgagactc 60tcctgtgcag cctctggatt cacgtttagt agctatgcca tgaactgggt
ccgccaggct 120ccagggaagg ggctggattg ggtctcaggt atcagtggta
atggtggtag cacctactac 180gcagactccg tgaagggccg gttcaccatc
tccagagaca tttccaagaa cacgctgtat 240gtgcaaatgc acagcctgag
agtcgaggac acggccgttt actactgtgc gaaagcccgt 300tattacgatt
tttggggggg gaatttcgat ctctggggcc gtggcaccct ggtcactgtc 360tcctca
366618122PRTArtificial SequenceSynthetic 618Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45
Ser Gly Ile Ser Gly Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu
Tyr65 70 75 80 Val Gln Met His Ser Leu Arg Val Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Ala Arg Tyr Tyr Asp Phe Trp Gly Gly
Asn Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser
Ser 115 120 619324DNAArtificial SequenceSynthetic 619gaaattgtgt
tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60ctctcctgca
gggccagtca gagtgttagc atcaggtact tagcctggta tcagcagaaa
120cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac
tggcatccca 180gacaggttca gtgtcagtgt gtctgggaca gacttcactc
tcaccatcac tagactggag 240cctgaagatt ttgcagtcta ttactgtcag
caatatggta gttcaccgct cactttcggc 300ggagggacca aggtggagat caaa
324620108PRTArtificial SequenceSynthetic 620Glu Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Arg 20 25 30 Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60 Val Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu
Glu65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly
Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 621366DNAArtificial SequenceSynthetic 621gaggtgcagc
tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60tcctgtgcag
cctctggatt cacgtttagt agctatgcca tgagctgggt ccgccaggct
120ccagggaagg ggctggagtg ggtctcagct atcagtggta atggtggtag
cacctactac 180gcagactccg tgaagggccg gttcaccatc tccagagaca
attccaagaa cacgctgtat 240ctgcaaatga acagcctgag agccgaggac
acggccgtat attactgtgc gaaagcccgt 300tattacgatt tttggggggg
gaatttcgat ctctggggcc gtggcaccct ggtcactgtc 360tcctca
366622122PRTArtificial SequenceSynthetic 622Glu Val Gln Leu Leu Glu
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45
Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50
55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Lys Ala Arg Tyr Tyr Asp Phe Trp Gly Gly
Asn Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser
Ser 115 120 623324DNAArtificial SequenceSynthetic 623gaaattgtgt
tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60ctctcctgca
gggccagtca gagtgttagc atcaggtact tagcctggta ccagcagaaa
120cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac
tggcatccca 180gacaggttca gtggcagtgg gtctgggaca gacttcactc
tcaccatcag cagactggag 240cctgaagatt ttgcagtgta ttactgtcag
caatatggta gttcaccgct cactttcggc 300ggagggacca aggtggagat caaa
324624108PRTArtificial SequenceSynthetic 624Glu Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Arg 20 25 30 Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
Glu65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly
Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys 100 105 625381DNAArtificial SequenceSynthetic 625caggttcagc
tggtgcagtc tggacctgag gtgaagaacc ctggggcctc agtgaaggtc 60tcctgcaagg
cttctggtta cacctttacc acctatggta tcagttgggt acgacaggcc
120cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa
aacaaacgat 180gcacagaagt tccaggacag agtcgccatg accacagaca
catccacgag cacagcctac 240atggagctga ggagcctgag atctgacgac
acggccattt attactgttc gagagatcgt 300ttagtagtac cacctgccct
ttattattcc tactacgtta tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381626127PRTArtificial SequenceSynthetic 626Gln Val
Gln Leu Val Gln Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20
25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Asp Ala
Gln Lys Phe 50 55 60 Gln Asp Arg Val Ala Met Thr Thr Asp Thr Ser
Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp
Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val
Pro Pro Ala Leu Tyr Tyr Ser Tyr Tyr 100 105 110 Val Met Asp Val Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
62724DNAArtificial SequenceSynthetic 627ggttacacct ttaccaccta tggt
246288PRTArtificial SequenceSynthetic 628Gly Tyr Thr Phe Thr Thr
Tyr Gly1 5 62924DNAArtificial SequenceSynthetic 629atcagcggtt
acaatggtaa aaca 246308PRTArtificial SequenceSynthetic 630Ile Ser
Gly Tyr Asn Gly Lys Thr1 5 63160DNAArtificial SequenceSynthetic
631tcgagagatc gtttagtagt accacctgcc ctttattatt cctactacgt
tatggacgtc 6063220PRTArtificial SequenceSynthetic 632Ser Arg Asp
Arg Leu Val Val Pro Pro Ala Leu Tyr Tyr Ser Tyr Tyr1 5 10 15 Val
Met Asp Val 20 633336DNAArtificial SequenceSynthetic 633gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tttcagcaga ggccaggtca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336634112PRTArtificial SequenceSynthetic 634Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
63533DNAArtificial SequenceSynthetic 635caaagcctcg tatacagtga
tggaaacacc tac 3363611PRTArtificial SequenceSynthetic 636Gln Ser
Leu Val Tyr Ser Asp Gly Asn Thr Tyr1 5 10 6379DNAArtificial
SequenceSynthetic 637aaggtttct 96383PRTArtificial SequenceSynthetic
638Lys Val Ser1 63927DNAArtificial SequenceSynthetic 639atgcaaggta
cacactggcc gtacact 276409PRTArtificial SequenceSynthetic 640Met Gln
Gly Thr His Trp Pro Tyr Thr1 5 641381DNAArtificial
SequenceSynthetic 641caggttcagc tggtgcagtc tggacctgag gtgaagaacc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta
tcagttgggt acgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
atcagcggtt acaatggtaa aacaaacgat 180gcacagaagt tccaggacag
agtcgccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccattt attactgttc gagagatcgt
300ttagtagtac cacctgccct ttattattcc tactacgtta tggacgtctg
gggccaaggg 360accacggtca ccgtctcctc a 381642127PRTArtificial
SequenceSynthetic 642Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val
Lys Asn Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly
Tyr Asn Gly Lys Thr Asn Asp Ala Gln Lys Phe 50 55 60 Gln Asp Arg
Val Ala Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85 90
95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu Tyr Tyr Ser Tyr Tyr
100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 643336DNAArtificial SequenceSynthetic 643gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tttcagcaga ggccaggtca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336644112PRTArtificial SequenceSynthetic 644Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
645381DNAArtificial SequenceSynthetic 645caggttcagc tggtgcagtc
tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta
cacctttacc acctatggta tcagctgggt gcgacaggcc 120cctggacaag
ggcttgagtg gatgggatgg atcagcggtt acaatggtaa aacaaactat
180gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag
cacagcctac 240atggagctga ggagcctgag atctgacgac acggccgtgt
attactgttc gagagatcgt 300ttagtagtac cacctgccct ttattattcc
tactacgtta tggacgtctg ggggcaaggg 360accacggtca ccgtctcctc a
381646127PRTArtificial SequenceSynthetic 646Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Tyr Ala Gln Lys Leu 50
55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu
Tyr Tyr Ser Tyr Tyr 100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser 115 120 125 647336DNAArtificial
SequenceSynthetic 647gatgttgtga tgactcagtc tccactctcc ctgcccgtca
cccttggaca gccggcctcc 60atctcctgca ggtctagtca aagcctcgta tacagtgatg
gaaacaccta cttgaattgg 120tttcagcaga ggccaggcca atctccaagg
cgcctaattt ataaggtttc taaccgggac 180tctggggtcc cagacagatt
cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240agcagggtgg
aggctgagga tgttggggtt tattactgca tgcaaggtac acactggccg
300tacacttttg gccaggggac caagctggag atcaaa 336648112PRTArtificial
SequenceSynthetic 648Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly Asn Thr Tyr Leu Asn
Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile
Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 85 90
95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 649381DNAArtificial SequenceSynthetic 649caggttcagc
tggtgcagtc tggacctgag gtgaagaacc ctggggcctc agtgaaggtc 60tcctgcaagg
cttctggtta cacctttacc acctatggta tcagttgggt acgacaggcc
120cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa
aacaaacgat 180gcacagaagt tccaggacag agtcgccatg accacagaca
catccacgag cacagcctac 240atggagctga ggagcctgag atctgacgac
acggccattt attactgttc gagagatcgt 300ttagtagtac cacctgccct
taattattac tactacgtta tggacgtctg gggccaaggg 360accacggtca
ccgtctcctc a 381650127PRTArtificial SequenceSynthetic 650Gln Val
Gln Leu Val Gln Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20
25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40
45 Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Asp Ala Gln Lys Phe
50 55 60 Gln Asp Arg Val Ala Met Thr Thr Asp Thr Ser Thr Ser Thr
Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Ile Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala
Leu Asn Tyr Tyr Tyr Tyr 100 105 110 Val Met Asp Val Trp Gly Gln Gly
Thr Thr Val Thr Val Ser Ser 115 120 125 65124DNAArtificial
SequenceSynthetic 651ggttacacct ttaccaccta tggt 246528PRTArtificial
SequenceSynthetic 652Gly Tyr Thr Phe Thr Thr Tyr Gly1 5
65324DNAArtificial SequenceSynthetic 653atcagcggtt acaatggtaa aaca
246548PRTArtificial SequenceSynthetic 654Ile Ser Gly Tyr Asn Gly
Lys Thr1 5 65560DNAArtificial SequenceSynthetic 655tcgagagatc
gtttagtagt accacctgcc cttaattatt actactacgt tatggacgtc
6065620PRTArtificial SequenceSynthetic 656Ser Arg Asp Arg Leu Val
Val Pro Pro Ala Leu Asn Tyr Tyr Tyr Tyr1 5 10 15 Val Met Asp Val 20
657336DNAArtificial SequenceSynthetic 657gatgttgtga tgactcagtc
tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gaaacaccta cttgaattgg 120tttcagcaga
ggccaggtca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac
actgaaaatc 240agcagggtgg aggctgagga tgttggggtt tattactgca
tgcaaggtac acactggccg 300tacacttttg gccaggggac caagctggag atcaaa
336658112PRTArtificial SequenceSynthetic 658Asp Val Val Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr
Lys Leu Glu Ile Lys 100 105 110 65933DNAArtificial
SequenceSynthetic 659caaagcctcg tatacagtga tggaaacacc tac
3366011PRTArtificial SequenceSynthetic 660Gln Ser Leu Val Tyr Ser
Asp Gly Asn Thr Tyr1 5 10 6619DNAArtificial SequenceSynthetic
661aaggtttct 96623PRTArtificial SequenceSynthetic 662Lys Val Ser1
66327DNAArtificial SequenceSynthetic 663atgcaaggta cacactggcc
gtacact 276649PRTArtificial SequenceSynthetic 664Met Gln Gly Thr
His Trp Pro Tyr Thr1 5 665381DNAArtificial SequenceSynthetic
665caggttcagc tggtgcagtc tggacctgag gtgaagaacc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta tcagttgggt
acgacaggcc 120cctggacaag ggcttgagtg gatgggatgg atcagcggtt
acaatggtaa aacaaacgat 180gcacagaagt tccaggacag agtcgccatg
accacagaca catccacgag cacagcctac 240atggagctga ggagcctgag
atctgacgac acggccattt attactgttc gagagatcgt 300ttagtagtac
cacctgccct taattattac tactacgtta tggacgtctg gggccaaggg
360accacggtca ccgtctcctc a 381666127PRTArtificial SequenceSynthetic
666Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn
Asp Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Ala Met Thr Thr Asp
Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu
Val Val Pro Pro Ala Leu Asn Tyr Tyr Tyr Tyr 100 105 110 Val Met Asp
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
667336DNAArtificial SequenceSynthetic 667gatgttgtga tgactcagtc
tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gaaacaccta cttgaattgg 120tttcagcaga
ggccaggtca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac
actgaaaatc 240agcagggtgg aggctgagga tgttggggtt tattactgca
tgcaaggtac acactggccg 300tacacttttg gccaggggac caagctggag atcaaa
336668112PRTArtificial SequenceSynthetic 668Asp Val Val Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr
Lys Leu Glu Ile Lys 100 105 110 669381DNAArtificial
SequenceSynthetic 669caggttcagc tggtgcagtc tggagctgag gtgaagaagc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta
tcagctgggt gcgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
atcagcggtt acaatggtaa aacaaactat 180gcacagaagc tccagggcag
agtcaccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccgtgt attactgttc gagagatcgt
300ttagtagtac cacctgccct taattattac tactacgtta tggacgtctg
ggggcaaggg 360accacggtca ccgtctcctc a 381670127PRTArtificial
SequenceSynthetic 670Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly
Tyr Asn Gly Lys Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg
Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu Asn Tyr Tyr Tyr Tyr
100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser 115 120 125 671336DNAArtificial SequenceSynthetic 671gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336672112PRTArtificial SequenceSynthetic 672Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
673381DNAArtificial SequenceSynthetic 673caggttcagc tggtgcagtc
tggacctgag gtgaagaacc ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta
cacctttacc acctatggta tcagttgggt acgacaggcc 120cctggacaag
ggcttgagtg gatgggatgg atcagcggtt acaatggtaa aacaaacgat
180gcacagaagt tccaggacag agtcgccatg accacagaca catccacgag
cacagcctac 240atggagctga ggagcctgag atctgacgac acggccattt
attactgttc gagagatcgt 300ttagtagtac cacctgccct ttattattac
tactacgtta tggacgtctg gggccaaggg 360accacggtca ccgtctcctc a
381674127PRTArtificial SequenceSynthetic 674Gln Val Gln Leu Val Gln
Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn Asp Ala Gln Lys Phe 50
55 60 Gln Asp Arg Val Ala Met Thr Thr Asp Thr Ser Thr Ser Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile
Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu
Tyr Tyr Tyr Tyr Tyr 100 105 110 Val Met Asp Val Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser 115 120 125 67524DNAArtificial
SequenceSynthetic 675ggttacacct ttaccaccta tggt 246768PRTArtificial
SequenceSynthetic 676Gly Tyr Thr Phe Thr Thr Tyr Gly1 5
67724DNAArtificial SequenceSynthetic 677atcagcggtt acaatggtaa aaca
246788PRTArtificial SequenceSynthetic 678Ile Ser Gly Tyr Asn Gly
Lys Thr1 5 67960DNAArtificial SequenceSynthetic 679tcgagagatc
gtttagtagt accacctgcc ctttattatt actactacgt tatggacgtc
6068020PRTArtificial SequenceSynthetic 680Ser Arg Asp Arg Leu Val
Val Pro Pro Ala Leu Tyr Tyr Tyr Tyr Tyr1 5 10 15 Val Met Asp Val 20
681336DNAArtificial SequenceSynthetic 681gatgttgtga tgactcagtc
tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gaaacaccta cttgaattgg 120tttcagcaga
ggccaggtca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac
actgaaaatc 240agcagggtgg aggctgagga tgttggggtt tattactgca
tgcaaggtac acactggccg 300tacacttttg gccaggggac caagctggag atcaaa
336682112PRTArtificial SequenceSynthetic 682Asp Val Val Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr
Lys Leu Glu Ile Lys 100 105 110 68333DNAArtificial
SequenceSynthetic 683caaagcctcg tatacagtga tggaaacacc tac
3368411PRTArtificial SequenceSynthetic 684Gln Ser Leu Val Tyr Ser
Asp Gly Asn Thr Tyr1 5 10 6859DNAArtificial SequenceSynthetic
685aaggtttct 96863PRTArtificial SequenceSynthetic 686Lys Val Ser1
68727DNAArtificial SequenceSynthetic 687atgcaaggta cacactggcc
gtacact 276889PRTArtificial SequenceSynthetic 688Met Gln Gly Thr
His Trp Pro Tyr Thr1 5 689381DNAArtificial SequenceSynthetic
689caggttcagc tggtgcagtc tggacctgag gtgaagaacc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta tcagttgggt
acgacaggcc 120cctggacaag ggcttgagtg gatgggatgg atcagcggtt
acaatggtaa aacaaacgat 180gcacagaagt tccaggacag agtcgccatg
accacagaca catccacgag cacagcctac 240atggagctga ggagcctgag
atctgacgac acggccattt attactgttc gagagatcgt 300ttagtagtac
cacctgccct ttattattac tactacgtta tggacgtctg gggccaaggg
360accacggtca ccgtctcctc a 381690127PRTArtificial SequenceSynthetic
690Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Asn Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Lys Thr Asn
Asp Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Ala Met Thr Thr Asp
Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ser Arg Asp Arg Leu
Val Val Pro Pro Ala Leu Tyr Tyr Tyr Tyr Tyr 100 105 110 Val Met Asp
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
691336DNAArtificial SequenceSynthetic 691gatgttgtga tgactcagtc
tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca ggtctagtca
aagcctcgta tacagtgatg gaaacaccta cttgaattgg 120tttcagcaga
ggccaggtca atctccaagg cgcctaattt ataaggtttc taaccgggac
180tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac
actgaaaatc 240agcagggtgg aggctgagga tgttggggtt tattactgca
tgcaaggtac acactggccg 300tacacttttg gccaggggac caagctggag atcaaa
336692112PRTArtificial SequenceSynthetic 692Asp Val Val Met Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10 15 Gln Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly
Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr
Lys Leu Glu Ile Lys 100 105 110 693381DNAArtificial
SequenceSynthetic 693caggttcagc tggtgcagtc tggagctgag gtgaagaagc
ctggggcctc agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc acctatggta
tcagctgggt gcgacaggcc 120cctggacaag ggcttgagtg gatgggatgg
atcagcggtt acaatggtaa aacaaactat 180gcacagaagc tccagggcag
agtcaccatg accacagaca catccacgag cacagcctac 240atggagctga
ggagcctgag atctgacgac acggccgtgt attactgttc gagagatcgt
300ttagtagtac cacctgccct ttattattac tactacgtta tggacgtctg
ggggcaaggg 360accacggtca ccgtctcctc a 381694127PRTArtificial
SequenceSynthetic 694Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly
Tyr Asn Gly Lys Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg
Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80 Met
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90
95
Ser Arg Asp Arg Leu Val Val Pro Pro Ala Leu Tyr Tyr Tyr Tyr Tyr 100
105 110 Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125 695336DNAArtificial SequenceSynthetic 695gatgttgtga
tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60atctcctgca
ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg
120tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc
taaccgggac 180tctggggtcc cagacagatt cagcggcagt gggtcaggca
ctgatttcac actgaaaatc 240agcagggtgg aggctgagga tgttggggtt
tattactgca tgcaaggtac acactggccg 300tacacttttg gccaggggac
caagctggag atcaaa 336696112PRTArtificial SequenceSynthetic 696Asp
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly1 5 10
15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly
Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp
Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Lys Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val
Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
697384DNAArtificial SequenceSynthetic 697caggtgcacc tggtggagtc
tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60tcctgtgcag cctctggatt
caccttcagt gaccactaca tgagctggat ccgccaggct 120ccagggaagg
ggctggagtg gatttcatac attagtaatg atggtggtac caaatactat
180gtggactctg tggagggccg attcatcatt tccagggaca acgccaagaa
ctcattgtat 240ctacatatga acagcctcag agccgacgac acggccgtgt
attactgtgc gagagatcag 300ggatatattg gctacgactc gtattattac
tattcctacg gtatggacgt ctggggccaa 360gggaccacgg tcaccgtcgc ctca
384698128PRTArtificial SequenceSynthetic 698Gln Val His Leu Val Glu
Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15 Ser Leu Arg Leu
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20 25 30 Tyr Met
Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45
Ser Tyr Ile Ser Asn Asp Gly Gly Thr Lys Tyr Tyr Val Asp Ser Val 50
55 60 Glu Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr65 70 75 80 Leu His Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Asp Gln Gly Tyr Ile Gly Tyr Asp Ser
Tyr Tyr Tyr Tyr Ser 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly
Thr Thr Val Thr Val Ala Ser 115 120 125 69924DNAArtificial
SequenceSynthetic 699ggattcacct tcagtgacca ctac 247008PRTArtificial
SequenceSynthetic 700Gly Phe Thr Phe Ser Asp His Tyr1 5
70124DNAArtificial SequenceSynthetic 701attagtaatg atggtggtac caaa
247028PRTArtificial SequenceSynthetic 702Ile Ser Asn Asp Gly Gly
Thr Lys1 5 70363DNAArtificial SequenceSynthetic 703gcgagagatc
agggatatat tggctacgac tcgtattatt actattccta cggtatggac 60gtc
6370421PRTArtificial SequenceSynthetic 704Ala Arg Asp Gln Gly Tyr
Ile Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser1 5 10 15 Tyr Gly Met Asp
Val 20 705321DNAArtificial SequenceSynthetic 705aaaattgtgt
tgacgcagtc tccaggcacc ctgcctttgt ttccagggga aagagccacc 60ctctcctgta
gggccagtca gagtgttaac aacaaattct tagcctggta ccagcagaaa
120tctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac
tggcatccca 180gacaggttca gtggcagtgg gtctgggacc gacttcactc
tcaccatcag cggactggag 240cctgaagatt ttgaagtgta ttattgtcaa
gtatatggta actcactcac tttcggcgga 300gggaccaagg tggagatcaa g
321706107PRTArtificial SequenceSynthetic 706Lys Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Pro Leu Phe Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20 25 30 Phe Leu
Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu
Glu65 70 75 80 Pro Glu Asp Phe Glu Val Tyr Tyr Cys Gln Val Tyr Gly
Asn Ser Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 70721DNAArtificial SequenceSynthetic 707cagagtgtta
acaacaaatt c 217087PRTArtificial SequenceSynthetic 708Gln Ser Val
Asn Asn Lys Phe1 5 7099DNAArtificial SequenceSynthetic 709ggtgcatcc
97103PRTArtificial SequenceSynthetic 710Gly Ala Ser1
71124DNAArtificial SequenceSynthetic 711caagtatatg gtaactcact cact
247128PRTArtificial SequenceSynthetic 712Gln Val Tyr Gly Asn Ser
Leu Thr1 5 713384DNAArtificial SequenceSynthetic 713caggtgcagc
tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt gaccactaca tgagctggat ccgccaggct
120ccagggaagg ggctggagtg gatttcatac attagtaatg atggtggtac
caaatactat 180gtggactctg tggagggccg attcatcatt tccagggaca
acgccaagaa ctcattgtat 240ctacatatga acagcctcag agccgacgac
acggccgtgt attactgtgc gagagatcag 300ggatatattg gctacgactc
gtattattac tattcctacg gtatggacgt ctggggccaa 360gggaccacgg
tcaccgtctc ctca 384714128PRTArtificial SequenceSynthetic 714Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20
25 30 Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Ile 35 40 45 Ser Tyr Ile Ser Asn Asp Gly Gly Thr Lys Tyr Tyr Val
Asp Ser Val 50 55 60 Glu Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr65 70 75 80 Leu His Met Asn Ser Leu Arg Ala Asp
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gln Gly Tyr Ile
Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser 100 105 110 Tyr Gly Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
715321DNAArtificial SequenceSynthetic 715gaaattgtgt tgacgcagtc
tccaggcacc ctgcctttgt ttccagggga aagagccacc 60ctctcctgta gggccagtca
gagtgttaac aacaaattct tagcctggta ccagcagaaa 120tctggccagg
ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca
180gacaggttca gtggcagtgg gtctgggacc gacttcactc tcaccatcag
cggactggag 240cctgaagatt ttgaagtgta ttattgtcaa gtatatggta
actcactcac tttcggcgga 300gggaccaagg tggagatcaa a
321716107PRTArtificial SequenceSynthetic 716Glu Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Pro Leu Phe Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20 25 30 Phe Leu
Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu
Glu65 70 75 80 Pro Glu Asp Phe Glu Val Tyr Tyr Cys Gln Val Tyr Gly
Asn Ser Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 717384DNAArtificial SequenceSynthetic 717caggtgcagc
tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60tcctgtgcag
cctctggatt caccttcagt gaccactaca tgagctggat ccgccaggct
120ccagggaagg ggctggagtg ggtttcatac attagtaatg atggtggtac
caaatactac 180gcagactctg tgaagggccg attcaccatc tccagggaca
acgccaagaa ctcactgtat 240ctgcaaatga acagcctgag agccgaggac
acggccgtgt attactgtgc gagagatcag 300ggatatattg gctacgactc
gtattattac tattcctacg gtatggacgt ctgggggcaa 360gggaccacgg
tcaccgtctc ctca 384718128PRTArtificial SequenceSynthetic 718Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20
25 30 Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Tyr Ile Ser Asn Asp Gly Gly Thr Lys Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gln Gly Tyr Ile
Gly Tyr Asp Ser Tyr Tyr Tyr Tyr Ser 100 105 110 Tyr Gly Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
719321DNAArtificial SequenceSynthetic 719gaaattgtgt tgacgcagtc
tccaggcacc ctgtctttgt ctccagggga aagagccacc 60ctctcctgca gggccagtca
gagtgttaac aacaaattct tagcctggta ccagcagaaa 120cctggccagg
ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca
180gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag
cagactggag 240cctgaagatt ttgcagtgta ttactgtcaa gtatatggta
actcactcac tttcggcgga 300gggaccaagg tggagatcaa a
321720107PRTArtificial SequenceSynthetic 720Glu Ile Val Leu Thr Gln
Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly1 5 10 15 Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Lys 20 25 30 Phe Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50
55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
Glu65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Val Tyr Gly
Asn Ser Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 721378DNAArtificial SequenceSynthetic 721caaattctgc
tggtgcaatc tggacctgag gtgaaggagc ctggggcctc agtgaaggtc 60tcctgcaagg
cttctggtta cacctttacc aactacgcta tcagctgggt gcgacaggtc
120cctggacaag ggcttgagtg gatgggatgg gtcagcgctt acaatggtca
cacaaactat 180gcacatgaag tccagggcag agtcaccatg accacagaca
catccacgac cacagcctac 240atggagctga ggagcctgag atctgacgac
acggccatgt attactgtgc gagagggggt 300gtagtcgtgc cagttgctcc
ccacttctac aacggtatgg acgtctgggg ccaagggacc 360acggtcaccg tctcctca
378722126PRTArtificial SequenceSynthetic 722Gln Ile Leu Leu Val Gln
Ser Gly Pro Glu Val Lys Glu Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ala Ile
Ser Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Val Ser Ala Tyr Asn Gly His Thr Asn Tyr Ala His Glu Val 50
55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Met
Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Val Val Pro Val Ala Pro
His Phe Tyr Asn Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr
Val Thr Val Ser Ser 115 120 125 72324DNAArtificial
SequenceSynthetic 723ggttacacct ttaccaacta cgct 247248PRTArtificial
SequenceSynthetic 724Gly Tyr Thr Phe Thr Asn Tyr Ala1 5
72524DNAArtificial SequenceSynthetic 725gtcagcgctt acaatggtca caca
247268PRTArtificial SequenceSynthetic 726Val Ser Ala Tyr Asn Gly
His Thr1 5 72757DNAArtificial SequenceSynthetic 727gcgagagggg
gtgtagtcgt gccagttgct ccccacttct acaacggtat ggacgtc
5772819PRTArtificial SequenceSynthetic 728Ala Arg Gly Gly Val Val
Val Pro Val Ala Pro His Phe Tyr Asn Gly1 5 10 15 Met Asp
Val729336DNAArtificial SequenceSynthetic 729gatattgtga tgactcagtt
tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca ggtctagtca
gagcctcctg catattaatg aatacaacta tttggattgg 120tacctaaaga
agccagggca gtctccacag ctcctgatct atttgggttt taatcgggcc
180tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac
actgaaaatc 240agcagagtgg aggctgagga tgttggggtc tattactgca
tgcaagctct tcaaactccg 300tggacgttcg gccaagggac caaggtggaa atcaaa
336730112PRTArtificial SequenceSynthetic 730Asp Ile Val Met Thr Gln
Phe Pro Leu Ser Leu Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ile 20 25 30 Asn Glu
Tyr Asn Tyr Leu Asp Trp Tyr Leu Lys Lys Pro Gly Gln Ser 35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50
55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
Ile65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys 100 105 110 73133DNAArtificial
SequenceSynthetic 731cagagcctcc tgcatattaa tgaatacaac tat
3373211PRTArtificial SequenceSynthetic 732Gln Ser Leu Leu His Ile
Asn Glu Tyr Asn Tyr1 5 10 7339DNAArtificial SequenceSynthetic
733ttgggtttt 97343PRTArtificial SequenceSynthetic 734Leu Gly Phe1
73527DNAArtificial SequenceSynthetic 735atgcaagctc ttcaaactcc
gtggacg 277369PRTArtificial SequenceSynthetic 736Met Gln Ala Leu
Gln Thr Pro Trp Thr1 5 737378DNAArtificial SequenceSynthetic
737caggttcagc tggtgcagtc tggacctgag gtgaaggagc ctggggcctc
agtgaaggtc 60tcctgcaagg cttctggtta cacctttacc aactacgcta tcagctgggt
gcgacaggtc 120cctggacaag ggcttgagtg gatgggatgg gtcagcgctt
acaatggtca cacaaactat 180gcacatgaag tccagggcag agtcaccatg
accacagaca catccacgac cacagcctac 240atggagctga ggagcctgag
atctgacgac acggccatgt attactgtgc gagagggggt 300gtagtcgtgc
cagttgctcc ccacttctac aacggtatgg acgtctgggg ccaagggacc
360acggtcaccg tctcctca 378738126PRTArtificial SequenceSynthetic
738Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Glu Pro Gly Ala1
5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Val Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Trp Val Ser Ala Tyr Asn Gly His Thr Asn
Tyr Ala His Glu Val 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp
Thr Ser Thr Thr Thr Ala Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Ser Asp Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val
Val Val Pro Val Ala Pro His Phe Tyr Asn Gly 100 105 110 Met Asp Val
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125
739336DNAArtificial SequenceSynthetic 739gatattgtga tgactcagtc
tccactctcc ctgcccgtca cccctggaga gccggcctcc 60atctcctgca ggtctagtca
gagcctcctg catattaatg
aatacaacta tttggattgg 120tacctaaaga agccagggca gtctccacag
ctcctgatct atttgggttt taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtc tattactgca tgcaagctct tcaaactccg
300tggacgttcg gccaagggac caaggtggaa atcaaa 336740112PRTArtificial
SequenceSynthetic 740Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ile 20 25 30 Asn Glu Tyr Asn Tyr Leu Asp
Trp Tyr Leu Lys Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110 741378DNAArtificial SequenceSynthetic 741caggttcagc
tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60tcctgcaagg
cttctggtta cacctttacc aactacgcta tcagctgggt gcgacaggcc
120cctggacaag ggcttgagtg gatgggatgg gtcagcgctt acaatggtca
cacaaactat 180gcacagaagc tccagggcag agtcaccatg accacagaca
catccacgag cacagcctac 240atggagctga ggagcctgag atctgacgac
acggccgtgt attactgtgc gagagggggt 300gtagtcgtgc cagttgctcc
ccacttctac aacggtatgg acgtctgggg gcaagggacc 360acggtcaccg tctcctca
378742126PRTArtificial SequenceSynthetic 742Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15 Ser Val Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ala Ile
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45
Gly Trp Val Ser Ala Tyr Asn Gly His Thr Asn Tyr Ala Gln Lys Leu 50
55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala
Tyr65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Val Val Pro Val Ala Pro
His Phe Tyr Asn Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr
Val Thr Val Ser Ser 115 120 125 743336DNAArtificial
SequenceSynthetic 743gatattgtga tgactcagtc tccactctcc ctgcccgtca
cccctggaga gccggcctcc 60atctcctgca ggtctagtca gagcctcctg catattaatg
aatacaacta tttggattgg 120tacctgcaga agccagggca gtctccacag
ctcctgatct atttgggttc taatcgggcc 180tccggggtcc ctgacaggtt
cagtggcagt ggatcaggca cagattttac actgaaaatc 240agcagagtgg
aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg
300tggacgttcg gccaagggac caaggtggaa atcaaa 336744112PRTArtificial
SequenceSynthetic 744Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu
Pro Val Thr Pro Gly1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser
Ser Gln Ser Leu Leu His Ile 20 25 30 Asn Glu Tyr Asn Tyr Leu Asp
Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile
Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile65 70 75 80 Ser
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90
95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110 7458PRTArtificial SequenceSynthetic 745Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa1 5 7468PRTArtificial SequenceSynthetic 746Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa1 5 74720PRTArtificial SequenceSynthetic
747Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa1
5 10 15 Xaa Xaa Xaa Xaa 20 74812PRTArtificial SequenceSynthetic
748Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa1 5 10
7493PRTArtificial SequenceSynthetic 749Xaa Xaa Xaa1
7509PRTArtificial SequenceSynthetic 750Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa1 5 751330PRTArtificial SequenceSynthetic 751Ala Ser Thr Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys1 5 10 15 Ser Thr
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35
40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
Thr Gln Thr65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys
Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp145 150 155 160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165
170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Asp Glu225 230 235 240 Leu Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290
295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330
752327PRTArtificial SequenceSynthetic 752Ala Ser Thr Lys Gly Pro
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg1 5 10 15 Ser Thr Ser Glu
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50
55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
Thr65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro
Ser Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp145 150 155 160 Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180
185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
Glu Glu Met Thr Lys225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser305
310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 753327PRTArtificial
SequenceSynthetic 753Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
Ala Pro Cys Ser Arg1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu
Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr65 70 75 80 Tyr
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90
95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln
Phe Asn Trp Tyr Val Asp145 150 155 160 Gly Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215
220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
Lys225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser305 310 315 320 Leu
Ser Leu Ser Leu Gly Lys 325 7542076DNAHomo sapiens 754atgggcaccg
tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg 60ctgctcctgg
gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag
120ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga
gcacggaacc 180acagccacct tccaccgctg cgccaaggat ccgtggaggt
tgcctggcac ctacgtggtg 240gtgctgaagg aggagaccca cctctcgcag
tcagagcgca ctgcccgccg cctgcaggcc 300caggctgccc gccggggata
cctcaccaag atcctgcatg tcttccatgg ccttcttcct 360ggcttcctgg
tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc
420gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa
cctggagcgg 480attacccctc cacggtaccg ggcggatgaa taccagcccc
ccgacggagg cagcctggtg 540gaggtgtatc tcctagacac cagcatacag
agtgaccacc gggaaatcga gggcagggtc 600atggtcaccg acttcgagaa
tgtgcccgag gaggacggga cccgcttcca cagacaggcc 660agcaagtgtg
acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc
720gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg
gaagggcacg 780gttagcggca ccctcatagg cctggagttt attcggaaaa
gccagctggt ccagcctgtg 840gggccactgg tggtgctgct gcccctggcg
ggtgggtaca gccgcgtcct caacgccgcc 900tgccagcgcc tggcgagggc
tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac 960gatgcctgcc
tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat
1020gcccaggacc agccggtgac cctggggact ttggggacca actttggccg
ctgtgtggac 1080ctctttgccc caggggagga catcattggt gcctccagcg
actgcagcac ctgctttgtg 1140tcacagagtg ggacatcaca ggctgctgcc
cacgtggctg gcattgcagc catgatgctg 1200tctgccgagc cggagctcac
cctggccgag ttgaggcaga gactgatcca cttctctgcc 1260aaagatgtca
tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg
1320gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg
caggactgtg 1380tggtcagcac actcggggcc tacacggatg gccacagcca
tcgcccgctg cgccccagat 1440gaggagctgc tgagctgctc cagtttctcc
aggagtggga agcggcgggg cgagcgcatg 1500gaggcccaag ggggcaagct
ggtctgccgg gcccacaacg cttttggggg tgagggtgtc 1560tacgccattg
ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca
1620ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca
cgtcctcaca 1680ggctgcagct cccactggga ggtggaggac cttggcaccc
acaagccgcc tgtgctgagg 1740ccacgaggtc agcccaacca gtgcgtgggc
cacagggagg ccagcatcca cgcttcctgc 1800tgccatgccc caggtctgga
atgcaaagtc aaggagcatg gaatcccggc ccctcaggag 1860caggtgaccg
tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg
1920acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag
gagccgggac 1980gtcagcacta caggcagcac cagcgaagag gccgtgacag
ccgttgccat ctgctgccgg 2040agccggcacc tggcgcaggc ctcccaggag ctccag
2076755692PRTHomo sapiens 755Met Gly Thr Val Ser Ser Arg Arg Ser
Trp Trp Pro Leu Pro Leu Leu1 5 10 15 Leu Leu Leu Leu Leu Leu Leu
Gly Pro Ala Gly Ala Arg Ala Gln Glu 20 25 30 Asp Glu Asp Gly Asp
Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 35 40 45 Glu Asp Gly
Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 50 55 60 His
Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val65 70 75
80 Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg
85 90 95 Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys
Ile Leu 100 105 110 His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val
Lys Met Ser Gly 115 120 125 Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro
His Val Asp Tyr Ile Glu 130 135 140 Glu Asp Ser Ser Val Phe Ala Gln
Ser Ile Pro Trp Asn Leu Glu Arg145 150 155 160 Ile Thr Pro Pro Arg
Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 165 170 175 Gly Ser Leu
Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 180 185 190 His
Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 195 200
205 Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp
210 215 220 Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp
Ala Gly225 230 235 240 Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg
Val Leu Asn Cys Gln 245 250 255 Gly Lys Gly Thr Val Ser Gly Thr Leu
Ile Gly Leu Glu Phe Ile Arg 260 265 270 Lys Ser Gln Leu Val Gln Pro
Val Gly Pro Leu Val Val Leu Leu Pro 275 280 285 Leu Ala Gly Gly Tyr
Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 290 295 300 Ala Arg Ala
Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp305 310 315 320
Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 325
330 335 Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu
Gly 340 345
350 Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile
355 360 365 Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln
Ser Gly 370 375 380 Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala
Ala Met Met Leu385 390 395 400 Ser Ala Glu Pro Glu Leu Thr Leu Ala
Glu Leu Arg Gln Arg Leu Ile 405 410 415 His Phe Ser Ala Lys Asp Val
Ile Asn Glu Ala Trp Phe Pro Glu Asp 420 425 430 Gln Arg Val Leu Thr
Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 435 440 445 His Gly Ala
Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 450 455 460 Ser
Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp465 470
475 480 Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg
Arg 485 490 495 Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys
Arg Ala His 500 505 510 Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile
Ala Arg Cys Cys Leu 515 520 525 Leu Pro Gln Ala Asn Cys Ser Val His
Thr Ala Pro Pro Ala Glu Ala 530 535 540 Ser Met Gly Thr Arg Val His
Cys His Gln Gln Gly His Val Leu Thr545 550 555 560 Gly Cys Ser Ser
His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 565 570 575 Pro Val
Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 580 585 590
Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 595
600 605 Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr
Val 610 615 620 Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala
Leu Pro Gly625 630 635 640 Thr Ser His Val Leu Gly Ala Tyr Ala Val
Asp Asn Thr Cys Val Val 645 650 655 Arg Ser Arg Asp Val Ser Thr Thr
Gly Ser Thr Ser Glu Glu Ala Val 660 665 670 Thr Ala Val Ala Ile Cys
Cys Arg Ser Arg His Leu Ala Gln Ala Ser 675 680 685 Gln Glu Leu Gln
690 756692PRTMacaca mulata 756Met Gly Thr Val Ser Ser Arg Arg Ser
Trp Trp Pro Leu Pro Leu Pro1 5 10 15 Leu Leu Leu Leu Leu Leu Leu
Gly Pro Ala Gly Ala Arg Ala Gln Glu 20 25 30 Asp Glu Asp Gly Asp
Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 35 40 45 Glu Asp Gly
Leu Ala Asp Ala Pro Glu His Gly Ala Thr Ala Thr Phe 50 55 60 His
Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val65 70 75
80 Val Leu Lys Glu Glu Thr His Arg Ser Gln Ser Glu Arg Thr Ala Arg
85 90 95 Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys
Ile Leu 100 105 110 His Val Phe His His Leu Leu Pro Gly Phe Leu Val
Lys Met Ser Gly 115 120 125 Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro
His Val Asp Tyr Ile Glu 130 135 140 Glu Asp Ser Ser Val Phe Ala Gln
Ser Ile Pro Trp Asn Leu Glu Arg145 150 155 160 Ile Thr Pro Ala Arg
Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Lys Gly 165 170 175 Gly Ser Leu
Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 180 185 190 His
Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Ser Val 195 200
205 Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp
210 215 220 Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp
Ala Gly225 230 235 240 Val Ala Lys Gly Ala Gly Leu Arg Ser Leu Arg
Val Leu Asn Cys Gln 245 250 255 Gly Lys Gly Thr Val Ser Gly Thr Leu
Ile Gly Leu Glu Phe Ile Arg 260 265 270 Lys Ser Gln Leu Val Gln Pro
Val Gly Pro Leu Val Val Leu Leu Pro 275 280 285 Leu Ala Gly Gly Tyr
Ser Arg Val Phe Asn Ala Ala Cys Gln Arg Leu 290 295 300 Ala Arg Ala
Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp305 310 315 320
Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 325
330 335 Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu
Gly 340 345 350 Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly
Glu Asp Ile 355 360 365 Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe
Val Ser Arg Ser Gly 370 375 380 Thr Ser Gln Ala Ala Ala His Val Ala
Gly Ile Ala Ala Met Met Leu385 390 395 400 Ser Ala Glu Pro Glu Leu
Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 405 410 415 His Phe Ser Ala
Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 420 425 430 Gln Arg
Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 435 440 445
His Arg Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 450
455 460 Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Gln
Asp465 470 475 480 Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser
Gly Lys Arg Arg 485 490 495 Gly Glu Arg Ile Glu Ala Gln Gly Gly Lys
Arg Val Cys Arg Ala His 500 505 510 Asn Ala Phe Gly Gly Glu Gly Val
Tyr Ala Ile Ala Arg Cys Cys Leu 515 520 525 Leu Pro Gln Val Asn Cys
Ser Val His Thr Ala Pro Pro Ala Gly Ala 530 535 540 Ser Met Gly Thr
Arg Val His Cys His Gln Gln Gly His Val Leu Thr545 550 555 560 Gly
Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 565 570
575 Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg
580 585 590 Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu
Glu Cys 595 600 605 Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu
Gln Val Ile Val 610 615 620 Ala Cys Glu Asp Gly Trp Thr Leu Thr Gly
Cys Ser Pro Leu Pro Gly625 630 635 640 Thr Ser His Val Leu Gly Ala
Tyr Ala Val Asp Asn Thr Cys Val Val 645 650 655 Arg Ser Arg Asp Val
Ser Thr Thr Gly Ser Thr Ser Lys Glu Ala Val 660 665 670 Ala Ala Val
Ala Ile Cys Cys Arg Ser Arg His Leu Val Gln Ala Ser 675 680 685 Gln
Glu Leu Gln 690 757694PRTMus muscular 757Met Gly Thr His Cys Ser
Ala Trp Leu Arg Trp Pro Leu Leu Pro Leu1 5 10 15 Leu Pro Pro Leu
Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ala 20 25 30 Gly Ala
Gln Asp Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu 35 40 45
Pro Ser Gln Glu Asp Gly Leu Ala Asp Glu Ala Ala His Val Ala Thr 50
55 60 Ala Thr Phe Arg Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly
Thr65 70 75 80 Tyr Ile Val Val Leu Met Glu Glu Thr Gln Arg Leu Gln
Ile Glu Gln 85 90 95 Thr Ala His Arg Leu Gln Thr Arg Ala Ala Arg
Arg Gly Tyr Val Ile 100 105 110 Lys Val Leu His Ile Phe Tyr Asp Leu
Phe Pro Gly Phe Leu Val Lys 115 120 125 Met Ser Ser Asp Leu Leu Gly
Leu Ala Leu Lys Leu Pro His Val Glu 130 135 140 Tyr Ile Glu Glu Asp
Ser Phe Val Phe Ala Gln Ser Ile Pro Trp Asn145 150 155 160 Leu Glu
Arg Ile Ile Pro Ala Trp His Gln Thr Glu Glu Asp Arg Ser 165 170 175
Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile 180
185 190 Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp
Phe 195 200 205 Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg
Gln Ala Ser 210 215 220 Lys Cys Asp Ser His Gly Thr His Leu Ala Gly
Val Val Ser Gly Arg225 230 235 240 Asp Ala Gly Val Ala Lys Gly Thr
Ser Leu His Ser Leu Arg Val Leu 245 250 255 Asn Cys Gln Gly Lys Gly
Thr Val Ser Gly Thr Leu Ile Gly Leu Glu 260 265 270 Phe Ile Arg Lys
Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val 275 280 285 Leu Leu
Pro Leu Ala Gly Gly Tyr Ser Arg Ile Leu Asn Ala Ala Cys 290 295 300
Arg His Leu Ala Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn305
310 315 320 Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro
Glu Val 325 330 335 Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro
Val Thr Leu Gly 340 345 350 Thr Leu Gly Thr Asn Phe Gly Arg Cys Val
Asp Leu Phe Ala Pro Gly 355 360 365 Lys Asp Ile Ile Gly Ala Ser Ser
Asp Cys Ser Thr Cys Phe Met Ser 370 375 380 Gln Ser Gly Thr Ser Gln
Ala Ala Ala His Val Ala Gly Ile Val Ala385 390 395 400 Arg Met Leu
Ser Arg Glu Pro Thr Leu Thr Leu Ala Glu Leu Arg Gln 405 410 415 Arg
Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe 420 425
430 Pro Glu Asp Gln Gln Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro
435 440 445 Pro Ser Thr His Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr
Val Trp 450 455 460 Ser Ala His Ser Gly Pro Thr Arg Thr Ala Thr Ala
Thr Ala Arg Cys465 470 475 480 Ala Pro Glu Glu Glu Leu Leu Ser Cys
Ser Ser Phe Ser Arg Ser Gly 485 490 495 Arg Arg Arg Gly Asp Trp Ile
Glu Ala Ile Gly Gly Gln Gln Val Cys 500 505 510 Lys Ala Leu Asn Ala
Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg 515 520 525 Cys Cys Leu
Val Pro Arg Ala Asn Cys Ser Ile His Asn Thr Pro Ala 530 535 540 Ala
Arg Ala Gly Leu Glu Thr His Val His Cys His Gln Lys Asp His545 550
555 560 Val Leu Thr Gly Cys Ser Phe His Trp Glu Val Glu Asp Leu Ser
Val 565 570 575 Arg Arg Gln Pro Ala Leu Arg Ser Arg Arg Gln Pro Gly
Gln Cys Val 580 585 590 Gly His Gln Ala Ala Ser Val Tyr Ala Ser Cys
Cys His Ala Pro Gly 595 600 605 Leu Glu Cys Lys Ile Lys Glu His Gly
Ile Ser Gly Pro Ser Glu Gln 610 615 620 Val Thr Val Ala Cys Glu Ala
Gly Trp Thr Leu Thr Gly Cys Asn Val625 630 635 640 Leu Pro Gly Ala
Ser Leu Thr Leu Gly Ala Tyr Ser Val Asp Asn Leu 645 650 655 Cys Val
Ala Arg Val His Asp Thr Ala Arg Ala Asp Arg Thr Ser Gly 660 665 670
Glu Ala Thr Val Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala 675
680 685 Lys Ala Ser Trp Val Gln 690 758653PRTHomo sapiens 758Glu
Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys1 5 10
15 Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
20 25 30 Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser
Thr Cys 35 40 45 Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp
Cys Glu Asp Gly 50 55 60 Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly
Leu Tyr Val Phe Gln Gly65 70 75 80 Asp Ser Ser Pro Cys Ser Ala Phe
Glu Phe His Cys Leu Ser Gly Glu 85 90 95 Cys Ile His Ser Ser Trp
Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 100 105 110 Lys Ser Asp Glu
Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 115 120 125 Phe Gln
Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 130 135 140
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn145
150 155 160 Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser
Gly Glu 165 170 175 Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg
Asp Cys Arg Asp 180 185 190 Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly
Thr Asn Glu Cys Leu Asp 195 200 205 Asn Asn Gly Gly Cys Ser His Val
Cys Asn Asp Leu Lys Ile Gly Tyr 210 215 220 Glu Cys Leu Cys Pro Asp
Gly Phe Gln Leu Val Ala Gln Arg Arg Cys225 230 235 240 Glu Asp Ile
Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 245 250 255 Val
Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 260 265
270 Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
275 280 285 Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu
Asp Arg 290 295 300 Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn
Val Val Ala Leu305 310 315 320 Asp Thr Glu Val Ala Ser Asn Arg Ile
Tyr Trp Ser Asp Leu Ser Gln 325 330 335 Arg Met Ile Cys Ser Thr Gln
Leu Asp Arg Ala His Gly Val Ser Ser 340 345 350 Tyr Asp Thr Val Ile
Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 355 360 365 Val Asp Trp
Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 370 375 380 Thr
Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe385 390
395 400 Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val
His 405 410 415 Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys
Ile Lys Lys 420 425 430 Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu
Val Thr Glu Asn Ile 435 440 445 Gln Trp Pro Asn Gly Ile Thr Leu Asp
Leu Leu Ser Gly Arg Leu Tyr 450 455 460 Trp Val Asp Ser Lys Leu His
Ser Ile Ser Ser Ile Asp Val Asn Gly465 470 475 480 Gly Asn Arg Lys
Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 485 490 495 Phe Ser
Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 500 505 510
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 515
520 525 Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe
His 530 535 540 Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg
Thr Thr Leu545 550 555 560 Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu
Pro Ala Pro Gln Ile Asn 565 570 575 Pro His Ser Pro
Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 580 585 590 Ala Arg
Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 595 600 605
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 610
615 620 Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg
Leu625 630 635 640 Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile
Val 645 650 759753PRTHomo sapiens 759Met Glu Arg Arg Ala Trp Ser
Leu Gln Cys Thr Ala Phe Val Leu Phe1 5 10 15 Cys Ala Trp Cys Ala
Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val 20 25 30 Asn Glu Trp
Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala 35 40 45 Ile
Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu 50 55
60 Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser
Arg65 70 75 80 Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp
Asp Arg Val 85 90 95 Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg
Ser Lys Arg Ser Ala 100 105 110 Leu Arg Asp Ser Ala Leu Asn Leu Phe
Asn Asp Pro Met Trp Asn Gln 115 120 125 Gln Trp Tyr Leu Gln Asp Thr
Arg Met Thr Ala Ala Leu Pro Lys Leu 130 135 140 Asp Leu His Val Ile
Pro Val Trp Gln Lys Gly Ile Thr Gly Lys Gly145 150 155 160 Val Val
Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr Asp 165 170 175
Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp Asn 180
185 190 Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys
His 195 200 205 Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn
Asn His Lys 210 215 220 Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val
Gly Gly Ile Arg Met225 230 235 240 Leu Asp Gly Ile Val Thr Asp Ala
Ile Glu Ala Ser Ser Ile Gly Phe 245 250 255 Asn Pro Gly His Val Asp
Ile Tyr Ser Ala Ser Trp Gly Pro Asn Asp 260 265 270 Asp Gly Lys Thr
Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala Phe 275 280 285 Glu Tyr
Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe Val 290 295 300
Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys Asp305
310 315 320 Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala
Ser Gln 325 330 335 Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser
Ser Thr Leu Ala 340 345 350 Thr Ser Tyr Ser Ser Gly Asp Tyr Thr Asp
Gln Arg Ile Thr Ser Ala 355 360 365 Asp Leu His Asn Asp Cys Thr Glu
Thr His Thr Gly Thr Ser Ala Ser 370 375 380 Ala Pro Leu Ala Ala Gly
Ile Phe Ala Leu Ala Leu Glu Ala Asn Pro385 390 395 400 Asn Leu Thr
Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser Glu 405 410 415 Tyr
Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala Gly 420 425
430 Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys Ala
435 440 445 Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro
Glu Lys 450 455 460 Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro
Arg Ala Leu Lys465 470 475 480 Ala Asn Gly Glu Val Ile Ile Glu Ile
Pro Thr Arg Ala Cys Glu Gly 485 490 495 Gln Glu Asn Ala Ile Lys Ser
Leu Glu His Val Gln Phe Glu Ala Thr 500 505 510 Ile Glu Tyr Ser Arg
Arg Gly Asp Leu His Val Thr Leu Thr Ser Ala 515 520 525 Ala Gly Thr
Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr Ser 530 535 540 Pro
Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp Gly545 550
555 560 Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser
Gly 565 570 575 Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu
Ile Leu His 580 585 590 Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln
Pro Arg Val Tyr Thr 595 600 605 Ser Tyr Asn Thr Val Gln Asn Asp Arg
Arg Gly Val Glu Lys Met Val 610 615 620 Asp Pro Gly Glu Glu Gln Pro
Thr Gln Glu Asn Pro Lys Glu Asn Thr625 630 635 640 Leu Val Ser Lys
Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg Asp 645 650 655 Glu Leu
Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu Gln 660 665 670
Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys Ser 675
680 685 Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala
Leu 690 695 700 Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu
Asp Ser Leu705 710 715 720 Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn
Thr Lys Pro Tyr Lys His 725 730 735 Arg Asp Asp Arg Leu Leu Gln Ala
Leu Val Asp Ile Leu Asn Glu Glu 740 745 750 Asn760785PRTHomo
sapiens 760Met Pro Lys Gly Arg Gln Lys Val Pro His Leu Asp Ala Pro
Leu Gly1 5 10 15 Leu Pro Thr Cys Leu Trp Leu Glu Leu Ala Gly Leu
Phe Leu Leu Val 20 25 30 Pro Trp Val Met Gly Leu Ala Gly Thr Gly
Gly Pro Asp Gly Gln Gly 35 40 45 Thr Gly Gly Pro Ser Trp Ala Val
His Leu Glu Ser Leu Glu Gly Asp 50 55 60 Gly Glu Glu Glu Thr Leu
Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala65 70 75 80 Ala Gly Leu Val
Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr 85 90 95 Leu Phe
Val Gln Pro Ala Gly His Arg Pro Ala Leu Glu Val Glu Ala 100 105 110
Ile Arg Gln Gln Val Glu Ala Val Leu Ala Gly His Glu Ala Val Arg 115
120 125 Trp His Ser Glu Gln Arg Leu Leu Arg Arg Ala Lys Arg Ser Val
His 130 135 140 Phe Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn
Asn Arg Arg145 150 155 160 Ser Pro Gly Arg Asp Ile Asn Val Thr Gly
Val Trp Glu Arg Asn Val 165 170 175 Thr Gly Arg Gly Val Thr Val Val
Val Val Asp Asp Gly Val Glu His 180 185 190 Thr Ile Gln Asp Ile Ala
Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp 195 200 205 Leu Asn Ser Asn
Asp Pro Asp Pro Met Pro His Pro Asp Val Glu Asn 210 215 220 Gly Asn
His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro225 230 235
240 Asn Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala
245 250 255 Gly Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu
Ala Val 260 265 270 Ala Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr
Ser Cys Ser Trp 275 280 285 Gly Pro Asp Asp Asp Gly Lys Thr Val Asp
Gly Pro His Gln Leu Gly 290 295 300 Lys Ala Ala Leu Gln His Gly Val
Ile Ala Gly Arg Gln Gly Phe Gly305 310 315 320 Ser Ile Phe Val Val
Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn 325 330 335 Cys Asn Tyr
Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly 340 345 350 Ala
Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala 355 360
365 Ser Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser
370 375 380 Ile Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys
Thr Glu385 390 395 400 Gly His Thr Gly Thr Ser Ala Ala Ala Pro Leu
Ala Ala Gly Met Ile 405 410 415 Ala Leu Met Leu Gln Val Arg Pro Cys
Leu Thr Trp Arg Asp Val Gln 420 425 430 His Ile Ile Val Phe Thr Ala
Thr Arg Tyr Glu Asp Arg Arg Ala Glu 435 440 445 Trp Val Thr Asn Glu
Ala Gly Phe Ser His Ser His Gln His Gly Phe 450 455 460 Gly Leu Leu
Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr465 470 475 480
Ser Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn 485
490 495 Lys Ala Ile Pro Gln Ser Pro Arg Ser Leu Glu Val Leu Trp Asn
Val 500 505 510 Ser Arg Met Asp Leu Glu Met Ser Gly Leu Lys Thr Leu
Glu His Val 515 520 525 Ala Val Thr Val Ser Ile Thr His Pro Arg Arg
Gly Ser Leu Glu Leu 530 535 540 Lys Leu Phe Cys Pro Ser Gly Met Met
Ser Leu Ile Gly Ala Pro Arg545 550 555 560 Ser Met Asp Ser Asp Pro
Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr 565 570 575 Val Arg Cys Trp
Gly Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile 580 585 590 Arg Asp
Val Gly Asp Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp 595 600 605
Gln Leu Thr Leu Tyr Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp 610
615 620 Arg Gln Arg Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His
Asp625 630 635 640 Asp Phe Ala Leu Pro Cys Pro Pro Gly Leu Lys Ile
Pro Glu Glu Asp 645 650 655 Gly Tyr Thr Ile Thr Pro Asn Thr Leu Lys
Thr Leu Val Leu Val Gly 660 665 670 Cys Phe Thr Val Phe Trp Thr Val
Tyr Tyr Met Leu Glu Val Tyr Leu 675 680 685 Ser Gln Arg Asn Val Ala
Ser Asn Gln Val Cys Arg Ser Gly Pro Cys 690 695 700 His Trp Pro His
Arg Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu705 710 715 720 Glu
Ser Val Pro Leu Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr 725 730
735 Glu Ser Arg Gly Pro Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu
740 745 750 Leu Glu Gln Gly Asp Trp Ser Leu Ser Gln Asn Lys Ser Ala
Leu Asp 755 760 765 Cys Pro His Gln His Leu Asp Val Pro His Gly Lys
Glu Glu Gln Ile 770 775 780 Cys785 761692PRTMacaca fascicularis
761Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Pro1
5 10 15 Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln
Glu 20 25 30 Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu
Arg Ser Glu 35 40 45 Glu Asp Gly Leu Ala Asp Ala Pro Glu His Gly
Ala Thr Ala Thr Phe 50 55 60 His Arg Cys Ala Lys Asp Pro Trp Arg
Leu Pro Gly Thr Tyr Val Val65 70 75 80 Val Leu Lys Glu Glu Thr His
Arg Ser Gln Ser Glu Arg Thr Ala Arg 85 90 95 Arg Leu Gln Ala Gln
Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 100 105 110 His Val Phe
His His Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 115 120 125 Asp
Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 130 135
140 Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu
Arg145 150 155 160 Ile Thr Pro Ala Arg Tyr Arg Ala Asp Glu Tyr Gln
Pro Pro Lys Gly 165 170 175 Gly Ser Leu Val Glu Val Tyr Leu Leu Asp
Thr Ser Ile Gln Ser Asp 180 185 190 His Arg Glu Ile Glu Gly Arg Val
Met Val Thr Asp Phe Glu Ser Val 195 200 205 Pro Glu Glu Asp Gly Thr
Arg Phe His Arg Gln Ala Ser Lys Cys Asp 210 215 220 Ser His Gly Thr
His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly225 230 235 240 Val
Ala Lys Gly Ala Gly Leu Arg Ser Leu Arg Val Leu Asn Cys Gln 245 250
255 Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg
260 265 270 Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu
Leu Pro 275 280 285 Leu Ala Gly Gly Tyr Ser Arg Val Phe Asn Ala Ala
Cys Gln Arg Leu 290 295 300 Ala Arg Ala Gly Val Val Leu Val Thr Ala
Ala Gly Asn Phe Arg Asp305 310 315 320 Asp Ala Cys Leu Tyr Ser Pro
Ala Ser Ala Pro Glu Val Ile Thr Val 325 330 335 Gly Ala Thr Asn Ala
Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 340 345 350 Thr Asn Phe
Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 355 360 365 Ile
Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Arg Ser Gly 370 375
380 Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met
Leu385 390 395 400 Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg
Gln Arg Leu Ile 405 410 415 His Phe Ser Ala Lys Asp Val Ile Asn Glu
Ala Trp Phe Pro Glu Asp 420 425 430 Gln Arg Val Leu Thr Pro Asn Leu
Val Ala Ala Leu Pro Pro Ser Thr 435 440 445 His Arg Ala Gly Trp Gln
Leu Phe Cys Arg Thr Val Trp Ser Ala His 450 455 460 Ser Gly Pro Thr
Arg Met Ala Thr Ala Val Ala Arg Cys Ala Gln Asp465 470 475 480 Glu
Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 485 490
495 Gly Glu Arg Ile Glu Ala Gln Gly Gly Lys Arg Val Cys Arg Ala His
500 505 510 Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys
Cys Leu 515 520 525 Leu Pro Gln Val Asn Cys Ser Val His Thr Ala Pro
Pro Ala Gly Ala 530 535 540 Ser Met Gly Thr Arg Val His Cys His Gln
Gln Gly His Val Leu Thr545 550 555 560 Gly Cys Ser Ser His Trp Glu
Val Glu Asp Leu Gly Thr His Lys Pro 565 570 575 Pro Val Leu Arg Pro
Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 580 585 590 Glu Ala Ser
Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 595 600 605 Lys
Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Ile Val 610 615
620 Ala Cys Glu Asp Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro
Gly625 630 635 640 Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn
Thr Cys Val Val 645 650 655 Arg Ser Arg Asp Val Ser Thr Thr Gly Ser
Thr Ser Glu Glu Ala Val 660 665 670 Ala Ala Val Ala Ile Cys Cys Arg
Ser Arg His Leu Val Gln Ala Ser 675 680 685 Gln Glu Leu Gln 690
762698PRTMesocricetus
auratus 762Met Gly Thr Ser Cys Ser Ala Arg Pro Arg Trp Leu Leu Ser
Pro Leu1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Tyr Met Gly Ala
Ser Ala Gln Asp 20 25 30 Glu Asp Ala Glu Tyr Glu Glu Leu Met Leu
Thr Leu Gln Ser Gln Asp 35 40 45 Asp Gly Leu Ala Asp Glu Thr Asp
Glu Ala Pro Gln Gly Ala Thr Ala 50 55 60 Ala Phe His Arg Cys Pro
Glu Glu Ala Trp Arg Val Pro Gly Thr Tyr65 70 75 80 Ile Val Met Leu
Ala Glu Glu Ala Gln Trp Val His Ile Glu Gln Thr 85 90 95 Met His
Arg Leu Gln Thr Gln Ala Ala Arg Arg Gly Tyr Val Ile Lys 100 105 110
Ile Gln His Ile Phe Tyr Asp Phe Leu Pro Ala Phe Val Val Lys Met 115
120 125 Ser Ser Asp Leu Leu Asp Leu Ala Leu Lys Leu Pro His Val Lys
Tyr 130 135 140 Ile Glu Glu Asp Ser Leu Val Phe Ala Gln Ser Ile Pro
Trp Asn Leu145 150 155 160 Asp Arg Ile Ile Pro Ala Gly Arg Gln Ala
Gln Glu Tyr Ser Ser Ser 165 170 175 Arg Lys Val Pro Ser Gly Ser Gly
Gln Val Glu Val Tyr Leu Leu Asp 180 185 190 Thr Ser Ile Gln Ser Asp
His Arg Glu Ile Glu Gly Arg Val Thr Val 195 200 205 Thr Asp Phe Asn
Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg 210 215 220 Gln Ala
Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val225 230 235
240 Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Thr Ile Leu His Gly Leu
245 250 255 Arg Val Leu Asn Cys Gln Gly Lys Gly Ile Val Ser Gly Ile
Leu Thr 260 265 270 Gly Leu Glu Phe Ile Trp Lys Ser Gln Leu Met Gln
Pro Ser Gly Pro 275 280 285 Gln Val Val Leu Leu Pro Leu Ala Gly Arg
Tyr Ser Arg Val Leu Asn 290 295 300 Thr Ala Cys Gln His Leu Ala Arg
Thr Gly Val Val Leu Val Ala Ala305 310 315 320 Ala Gly Asn Phe Arg
Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala 325 330 335 Pro Glu Val
Ile Thr Val Gly Ala Thr Asp Val Gln Asp Gln Pro Val 340 345 350 Thr
Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe 355 360
365 Ala Pro Gly Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Ala Cys
370 375 380 Phe Met Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val
Ala Gly385 390 395 400 Ile Val Ala Met Met Leu Thr Leu Glu Pro Glu
Leu Thr Leu Thr Glu 405 410 415 Leu Arg Gln Arg Leu Ile His Phe Ser
Thr Lys Asp Ala Ile Asn Met 420 425 430 Ala Trp Phe Pro Glu Asp Gln
Arg Val Leu Thr Pro Asn Leu Val Ala 435 440 445 Thr Leu Pro Pro Ser
Thr His Gly Thr Gly Gly Gln Leu Leu Cys Arg 450 455 460 Thr Val Trp
Ser Ala His Ser Gly Pro Thr Arg Ala Ala Thr Ala Thr465 470 475 480
Ala Arg Cys Ala Pro Gly Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser 485
490 495 Arg Ser Gly Arg Arg Arg Gly Asp Arg Ile Glu Ala Ala Gly Thr
Gln 500 505 510 Gln Val Cys Lys Ala Leu Asn Ala Phe Gly Gly Glu Gly
Val Tyr Ala 515 520 525 Val Ala Arg Cys Cys Leu Leu Pro Arg Ala Asn
Cys Ser Ile His Thr 530 535 540 Thr Pro Ala Ala Arg Thr Ser Leu Glu
Thr His Ala His Cys His Gln545 550 555 560 Lys Asp His Val Leu Thr
Gly Cys Ser Leu His Trp Glu Val Glu Gly 565 570 575 Ile Gly Val Gln
Pro Leu Ala Val Leu Arg Ser Arg His Gln Pro Gly 580 585 590 Gln Cys
Thr Gly His Arg Glu Ala Ser Val His Ala Ser Cys Cys His 595 600 605
Ala Pro Gly Leu Glu Cys Lys Ile Lys Glu His Gly Ile Ser Gly Pro 610
615 620 Ala Glu Gln Val Thr Val Ala Cys Glu Ala Gly Trp Thr Leu Thr
Gly625 630 635 640 Cys Asn Val Leu Pro Gly Ala Phe Ile Thr Leu Gly
Ala Tyr Ala Val 645 650 655 Asp Asn Thr Cys Val Ala Arg Ser Arg Val
Thr Asp Thr Ala Gly Arg 660 665 670 Thr Gly Glu Glu Ala Thr Val Ala
Ala Ala Ile Cys Cys Arg Asn Arg 675 680 685 Pro Ser Ala Lys Ala Ser
Trp Val His Gln 690 695 763691PRTRattus norvegicus 763Met Gly Ile
Arg Cys Ser Thr Trp Leu Arg Trp Pro Leu Ser Pro Gln1 5 10 15 Leu
Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ser Arg Ala Gln Asp 20 25
30 Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu Pro Ser Gln Glu
35 40 45 Asp Ser Leu Val Asp Glu Ala Ser His Val Ala Thr Ala Thr
Phe Arg 50 55 60 Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr
Tyr Val Val Val65 70 75 80 Leu Met Glu Glu Thr Gln Arg Leu Gln Val
Glu Gln Thr Ala His Arg 85 90 95 Leu Gln Thr Trp Ala Ala Arg Arg
Gly Tyr Val Ile Lys Val Leu His 100 105 110 Val Phe Tyr Asp Leu Phe
Pro Gly Phe Leu Val Lys Met Ser Ser Asp 115 120 125 Leu Leu Gly Leu
Ala Leu Lys Leu Pro His Val Glu Tyr Ile Glu Glu 130 135 140 Asp Ser
Leu Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile145 150 155
160 Ile Pro Ala Trp Gln Gln Thr Glu Glu Asp Ser Ser Pro Asp Gly Ser
165 170 175 Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser
Gly His 180 185 190 Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe
Asn Ser Val Pro 195 200 205 Glu Glu Asp Gly Thr Arg Phe His Arg Gln
Ala Ser Lys Cys Asp Ser 210 215 220 His Gly Thr His Leu Ala Gly Val
Val Ser Gly Arg Asp Ala Gly Val225 230 235 240 Ala Lys Gly Thr Ser
Leu His Ser Leu Arg Val Leu Asn Cys Gln Gly 245 250 255 Lys Gly Thr
Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys 260 265 270 Ser
Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val Leu Leu Pro Leu 275 280
285 Ala Gly Gly Tyr Ser Arg Ile Leu Asn Thr Ala Cys Gln Arg Leu Ala
290 295 300 Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn Phe Arg
Asp Asp305 310 315 320 Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu
Val Ile Thr Val Gly 325 330 335 Ala Thr Asn Ala Gln Asp Gln Pro Val
Thr Leu Gly Thr Leu Gly Thr 340 345 350 Asn Phe Gly Arg Cys Val Asp
Leu Phe Ala Pro Gly Lys Asp Ile Ile 355 360 365 Gly Ala Ser Ser Asp
Cys Ser Thr Cys Tyr Met Ser Gln Ser Gly Thr 370 375 380 Ser Gln Ala
Ala Ala His Val Ala Gly Ile Val Ala Met Met Leu Asn385 390 395 400
Arg Asp Pro Ala Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile Leu 405
410 415 Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe Pro Glu Asp
Gln 420 425 430 Arg Val Leu Thr Pro Asn Arg Val Ala Thr Leu Pro Pro
Ser Thr Gln 435 440 445 Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val
Trp Ser Ala His Ser 450 455 460 Gly Pro Thr Arg Thr Ala Thr Ala Thr
Ala Arg Cys Ala Pro Glu Glu465 470 475 480 Glu Leu Leu Ser Cys Ser
Ser Phe Ser Arg Ser Gly Arg Arg Arg Gly 485 490 495 Asp Arg Ile Glu
Ala Ile Gly Gly Gln Gln Val Cys Lys Ala Leu Asn 500 505 510 Ala Phe
Gly Gly Glu Gly Val Tyr Ala Val Ala Arg Cys Cys Leu Leu 515 520 525
Pro Arg Val Asn Cys Ser Ile His Asn Thr Pro Ala Ala Arg Ala Gly 530
535 540 Pro Gln Thr Pro Val His Cys His Gln Lys Asp His Val Leu Thr
Gly545 550 555 560 Cys Ser Phe His Trp Glu Val Glu Asn Leu Arg Ala
Gln Gln Gln Pro 565 570 575 Leu Leu Arg Ser Arg His Gln Pro Gly Gln
Cys Val Gly His Gln Glu 580 585 590 Ala Ser Val His Ala Ser Cys Cys
His Ala Pro Gly Leu Glu Cys Lys 595 600 605 Ile Lys Glu His Gly Ile
Ala Gly Pro Ala Glu Gln Val Thr Val Ala 610 615 620 Cys Glu Ala Gly
Trp Thr Leu Thr Gly Cys Asn Val Leu Pro Gly Ala625 630 635 640 Ser
Leu Pro Leu Gly Ala Tyr Ser Val Asp Asn Val Cys Val Ala Arg 645 650
655 Ile Arg Asp Ala Gly Arg Ala Asp Arg Thr Ser Glu Glu Ala Thr Val
660 665 670 Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala Lys Ala
Ser Trp 675 680 685 Val His Gln 690
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