U.S. patent application number 13/566143 was filed with the patent office on 2012-12-27 for method and system for providing targeted and individualized delivery of cosmetic actives.
Invention is credited to Fatemah Mohammadi, Tsung-wel Robert Mou, Lisa Qu.
Application Number | 20120325141 13/566143 |
Document ID | / |
Family ID | 42007441 |
Filed Date | 2012-12-27 |
United States Patent
Application |
20120325141 |
Kind Code |
A1 |
Mohammadi; Fatemah ; et
al. |
December 27, 2012 |
Method and System for Providing Targeted and Individualized
Delivery of Cosmetic Actives
Abstract
A system and method are provided for targeted and individualized
delivery of multiple skin benefit agents to the skin of a user. The
image of a predetermined treatment area of the user's skin is first
captured by an imaging device. The captured image data is then
analyzed by a computing device to generate a unique skin profile
for the user, which is indicative of the skin conditions at the
predetermined treatment area. Based on such skin profile, a
printing device prints out one or more cosmetic delivery sheets
that can be applied to the predetermined treatment area. Each of
the cosmetic delivery sheets contains a substrate with multiple
isolate, discrete regions, while at least two of the regions are
imprinted with different skin benefit agents for treating different
skin conditions of the predetermined treatment area according to
the unique skin profile of the user.
Inventors: |
Mohammadi; Fatemah;
(Hauppauge, NY) ; Mou; Tsung-wel Robert; (Stony
Brook, NY) ; Qu; Lisa; (Flushing, NY) |
Family ID: |
42007441 |
Appl. No.: |
13/566143 |
Filed: |
August 28, 2012 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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12533107 |
Jul 31, 2009 |
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13566143 |
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61097273 |
Sep 16, 2008 |
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Current U.S.
Class: |
118/300 |
Current CPC
Class: |
B41J 3/407 20130101;
A61P 17/00 20180101; A45D 44/005 20130101; A45D 44/002
20130101 |
Class at
Publication: |
118/300 |
International
Class: |
B05C 5/00 20060101
B05C005/00 |
Claims
1. A printer comprising cartridges that are filled with
compositions containing skin benefit agents, wherein said printer
is constructed to print the skin benefit agents onto a substrate
through a heatless printing process.
2. The printer of claim 10, wherein the heatless printing process
is achieved by using a pressure-driven ink jet.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a divisional of U.S. Non-Provisional
patent application Ser. Nos. 12/533,107 filed Jul. 31, 2009, which
claims priority from U.S. 61/097,273 filed Sep. 16, 2008.
FIELD OF THE INVENTION
[0002] The present invention relates to method and system for
achieving targeted and individualized delivery of one or more skin
benefit agents to the skin of an user in need of such skin benefit
agents, and to devices in the form of a single-use sheet for
containing and delivering the skin benefit agents to one or more
targeted areas of the skin. In particular, the invention relates to
a method of delivering one or more skin benefit agents to targeted
areas of the facial skin of a user based on the unique skin profile
of such user and to a cosmetic sheet mask which incorporates one or
more cosmetic or dermatological preparations for application to and
treatment of the targeted areas of the skin of the user.
BACKGROUND OF THE INVENTION
[0003] A variety of cosmetic patches or devices are commercially
marketed or described as being useful for the delivery of skin care
actives such as vitamins, anti-acne actives, moisturizers, and the
like. It has been known to use cosmetic sheets comprised of various
materials, such as non-woven cotton, elastically extendable or
stretchable materials, thermoplastics, tacky gel, etc., impregnated
with various cosmetic or dermatological preparations, for
application to the skin of the face, the neck and other areas of
the body. The cosmetic sheets comprise a flexible support adapted
to conform to the target areas when applied. The sheets also
contain a system for containing and delivering skin benefit agents
to the skin to which the sheet is applied. Currently, however,
facial sheet masks on the market are fully impregnated with active
ingredients and are applied to the entire face so as to deliver
these ingredients to the entire face. Alternatively, a patch is
applied only to certain areas, such as, under the eyes, to deliver
the skin benefit agent to only this locus. However, these articles
suffer drawbacks resulting in undesirable in-use characteristics as
perceived by the consumer. For example it has heretofore not been
possible with known full facial masks to target one or more
specific areas with one or more skin benefit agents, but only to
treat the entire face with one composition. Most consumers have
different concerns for their skin in different areas of their face.
For example many consumers have combination skin in which the
T-zone area (forehead, nose and chin) is oily while the remainder
of the face is dry. For another example some consumers may have
lines and wrinkles at the forehead, eye, and mouth areas, dry or
flaky skin at the cheek areas, and hyperpigmentation spots at other
areas. Each region would need different treatment products to
address the different concerns. Conventional masks can only address
one concern at a time by treating the entire facial skin, rather
than only the targeted areas.
[0004] There is therefore a need by consumers for cosmetic sheets
which can deliver multiple skin benefit agents to various targeted
areas of the skin of a user to address different skin conditions of
such a user based on his or her unique skin profile.
SUMMARY OF THE INVENTION
[0005] The cosmetic sheets according to the present invention are
provided with discrete regions, which are imprinted with different
skin benefit agents, so when such cosmetic sheets are applied to
and conformed to the skin, they can accurately deliver
pre-determined dosages of different skin care formulations to the
skin for treating different skin conditions or providing different
skin benefits. More preferably, the cosmetic sheets of the present
invention are not mass-produced like the conventional
"one-type-fits-all" products, but are specifically customized for
individual users according to their unique skin profiles.
[0006] Accordingly, the present invention in one aspect relates to
a system for targeted and individualized delivery of multiple skin
benefit agents to the skin of a user. Such system includes at
least: (a) an imaging device for capturing an image of a
predetermined treatment area of the user's skin; (b) an analyzing
device communicatively connected with the imaging device for
receiving data representative of the captured image from the
imaging device, analyzing such data, and generating a skin profile
indicative of the conditions of the predetermined treatment area of
the user's skin; and (c) a printing device communicatively
connected with the analyzing device for printing one or more
cosmetic delivery sheets, wherein the cosmetic delivery sheets are
arranged and constructed for conforming to the predetermined
treatment area of the user's skin, wherein each of the cosmetic
delivery sheets comprises a substrate with multiple isolate,
discrete regions, wherein at least two of the isolate, discrete
regions are imprinted with different skin benefit agents for
treating different skin conditions of the predetermined treatment
area according to the skin profile generated by the analyzing
device.
[0007] The present invention in another aspect relates to a
cosmetic delivery sheet arranged and constructed for conforming to
a predetermined treatment area of the skin of a user. Such a
cosmetic delivery sheet includes at least a substrate with multiple
isolate, discrete regions, wherein at least two of the isolate,
discrete regions are imprinted with different skin benefit agents
for treating different skin conditions of the predetermined
treatment area.
[0008] The present invention in a further aspect relates to a
printer that contains cartridges filled with compositions
containing skin benefit agents. Preferably, but not necessarily,
such a printer is constructed to print the skin benefit agents onto
a substrate through a heatless printing process.
[0009] The present invention in yet another aspect relates to a
method for targeted and individualized delivery of multiple skin
benefit agents to the skin of a user, which includes at least: (a)
capturing an image of a predetermined treatment area of the user's
skin; (b) analyzing the captured image data; (c) generating a skin
profile indicative of the conditions of the predetermined treatment
area of the user's skin; and (d) printing one or more cosmetic
delivery sheets based on the generated skin profile, wherein the
cosmetic delivery sheets are arranged and constructed for
conforming to the predetermined treatment area of the user's skin,
wherein each of the cosmetic delivery sheets comprises a substrate
with multiple isolate, discrete regions, wherein at least two of
the isolate, discrete regions are imprinted with different skin
benefit agents for treating different skin conditions of the
predetermined treatment area.
[0010] Other aspects and objectives of the present invention will
become more apparent from the ensuing description, examples, and
claims.
BRIEF DESCRIPTION OF THE DRAWINGS
[0011] FIG. 1 is a schematic representation of a facial mask
containing multiple isolate, discrete regions with different skin
benefit agents, according to one embodiment of the present
invention.
[0012] FIG. 2 is a schematic representation of a facial mask
according to a second embodiment of the present invention.
[0013] FIG. 3 is an exploded view of one isolate, discrete region
on the facial mask of FIG. 1.
DETAILED DESCRIPTION OF THE INVENTION AND PREFERRED EMBODIMENTS
THEREOF
[0014] Reference will now be made in detail to exemplary
embodiments of the invention. It is contemplated that a
computerized or computer-aided system is used for achieving the
targeted and individualized delivery of multiple skin benefit
agents to the skin of a user based on the unique skin profile of
the user. Cosmetic delivery products produced by the system of the
present invention are capable of delivering multiple skin benefit
agents to multiple target sections or regions on demand and
according to the user skin profile with precise dosage and location
control.
[0015] Preferably, such a system includes at least an imaging
device for capturing an image of the desired treatment area of the
user's skin. Such desired treatment skin area may be, for example,
full face, partial face, neck, thigh, or the like. In a
particularly preferred but not necessary embodiment of the present
invention, the desired treatment area is the full face of the user.
The imaging device is preferably a digital camera, which may
capture the images of the desired treatment area in conjunction
with a light source that delivers sufficient and consistent visible
or invisible light, such as infrared light or near infrared light.
The imaging device can be set in either a manual or an automatic
mode for identifying the desired treatment area.
[0016] The captured images are directly converted by such imaging
device into digital data and stored therein or sent to a personal
computer or other computerized analyzing device that is
communicatively connected with the imaging device. The analyzing
device is programmed for analyzing image data and generating a skin
profile indicative of the conditions of the desired treatment area
of the user's skin based on the image data. Preferably, the skin
profile defines skin regions with certain defects that need certain
types of treatment. The term "defects" as used herein broadly
covers any types of sub-optimal skin conditions, such as skin
dryness, flakiness, redness, oiliness, large pores, dullness, dark
spots, uneven skin tone, acne scars, fine lines and wrinkles,
under-eye dark circles, under-eye puffiness, cellulite, and the
like, or any types of abnormal skin conditions or disorders. More
preferably, the skin profile also defines the severity of the skin
defects. Such skin profile can be generated using various known
algorithms. Examples of these algorithms are described in greater
detail by Japanese Patent Application Publication No. 95-231883
entitled "Skin Surface Analysis System and Skin Surface Analysis
Method"; International Patent Application Publication No.
WO98/37811 entitled "Systems and Methods for the Multispectral
Imaging and Characterization of Skin Tissue"; and U.S. Pat. No.
5,016,173 entitled "Apparatus and Method for Monitoring Visually
Accessible Surfaces of the Body," the contents of which are
incorporated in their entireties for all purposes. Commercially
available skin imaging tools that can be used for diagnosing skin
defects in the present invention include, for example, the
VISIA.RTM. Complexion Analysis tools available from Canfield
Scientific, Inc. (Fairfield, N.J.), thermal camera system, laser
Doppler imaging system, translucency meter, mexameter,
Mexameter.RTM. MX18 available from CK Electronic (Koln, Germany),
the CR series Chroma Meters available from Konica Minolta Business
Solutions, U.S.A. (Ramsey, N.J.), the SIAMETRICS.TM. and
COSMETRICS.TM. skin visualization and measurement systems available
from Astron Clinica Ltd. (Cambridge, United Kingdoms), and the
like. If the severity of the skin defects is represented by a
numerical value, it may be desirable to normalize such value based
on the user's ethnic origin, age, geographic location, or any other
factor that may have an impact on the user's skin conditions.
[0017] Once the skin profile is generated, it is processed by well
known photo-editing and illustration software programs, such as
Adobe Photoshop Element 4.0, Microsoft PowerPoint 2003, and the
like, for creating images to be outputted to a printing device,
which corresponding print out one or more cosmetic delivery sheets
that are customized for the user based on his or her unique skin
conditions, Preferably, the printing device is a printer that
contains multiple cartridges, each of which is filled with a
composition containing one or more skin benefit agents. Because the
conventional thermal inkjet printing mechanism produce high
temperature environment at the print head during ink discharging
step, which may degrade or destabilize certain skin benefit agents,
it is preferred that the printing in the present invention is
carried out using a heatless printing mechanism. For example, a
pressure-driven ink jet can be used, in which pressure is created
on demand by a piezoelectric transducer to change the shape of an
internal diaphram in the inkjet print head and therefore force
droplets of the skin benefit agents contained in the ink tank to be
deposited onto the substrate. Suitable printing devices for the
practice of the present invention include, for example, the Epson
Workforce series, preferably Epson Workforce 30, the Spectra
piezoelectric printers from Fujifilm Dimatix, the RISO HC5500
inkjet printer, and the like. Alternatively, when the skin benefit
agents to be delivered are thermally stable or relatively less
susceptible to thermal degradation, conventional thermal inkjet
printers or low-heat inkjet printers can be used for practice of
the present invention.
[0018] By using the above-described heatless printing process, the
present invention successfully achieves delivery of multiple skin
benefit agents with little or no reduction in their biological
activities. First, the heatless printing process causes little or
no degradation of the skin benefit agents. Second, certain skin
benefit agents that are known to interfere with each other's
biological activities can be placed into separate cartridges and
deposited onto the substrate as separate droplets. More
importantly, the droplets of such interfering skin benefit agents
are sufficiently small in size that they can be arranged in a
scattered maimer. Consequently, such skin benefit agents can
provide simultaneous treatments to the same region, but without
having to be mixed with each other.
[0019] The cosmetic delivery sheets so printed could be used
anywhere on the face or body skin to predetermined areas for
delivery of ingredients via a sheet material mask or patch or
similar system. The exact size and shape of the cosmetic sheet will
depend upon the intended use and product characteristics. The
cosmetic sheets will have sufficient flexibility, and a size and
shape adapted to conform to the desired treatment area of the
user's skin. In a particularly preferred, but not necessary,
embodiment of the present invention, the cosmetic sheet is a facial
mask adapted to conform to facial features. It will be understood
that a variety of shapes and sizes may be accommodated according to
the invention. Such a cosmetic sheet may include a flexible
substrate that is formed of preferably but not necessarily,
water-soluble materials, such as sugar or polysaccharides,
collagen, and water-soluble film-forming polymers. The substrate
contains multiple isolate, discrete regions, while at least two of
such regions are imprinted with different skin benefit agents for
treating different skin conditions according to the skin profile of
the user.
[0020] Suitable skin benefit agents can be used in the present
invention include, but are not limited to: anti-wrinkle or
skin-tightening agents; anti-aging agents; moisturizing agents;
skin-whitening or depigmentation agents; anti-inflammatory agents;
anti-acne agents; DNA repair agents; skin lipid barrier repair
agents; anti-cellulite agents; wound-healing agents;
stretch-mark/scar removing agents; plumping agents; hair growth
retardation agents; hair growth stimulating agents; dark cycle
reduction or de-puffing agents; collagen synthesis or blood
circulation enhancing agents; antioxidants; sebum-controlling
agents; and pore-minimizing agents. Exemplary anti-wrinkle agents
include, but are not limited to, acetyl hexapeptide-8, palmitoyl
oligopeptide, dipeptide diaminobutyroyl, benzylamide diacetate, and
the like. Exemplary skin-tightening agents include, but are not
limited to, algae extract, pullulan, sweet almond seed extract,
carbomer, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, Quercus
suber extract, and the like. Exemplary anti-aging agents include,
but are not limited to, teprenone, trisodium resveratrol
triphosphate, Polygonum cuspidatum root extract, whey protein, and
the like. Exemplary moisturizing agents include, but are not
limited to, hyaluronic acid, glycerin, urea, trehalose, and the
like. Exemplary skin-whitening or depigmentation agents include,
but are not limited to, ascorbic acid, magnesium ascorbyl
phosphate, aminopropyl ascorbyl phosphate, mulberry root extract,
Scutellaria baicalensis extract, grape extract, ferulic acid,
hinokitol, and the like. Exemplary anti-inflammatory agents
include, but are not limited to, spike moss extract, seal whip
extract, Polygonum cuspidatum root extract, and the like. Exemplary
anti-acne agents include, but are not limited to, salicylic acid,
glycolic acid, lactobionic acid, and the like. Exemplary DNA repair
agents include, but are not limited to, C1-C8 alkyl
tetrahydroxycyclohexanoate, micrococcus lysate, bifida ferment
lysate, and the like. Exemplary skin lipid barrier repair agents
include, but are not limited to, phytosphingosine, linoleic acid,
cholesterol, and the like. Exemplary anti-cellulite agents include,
but are not limited to, Coleus forskohlii root extract, Magnolia
grandiflora bark extract, Nelubo nucifera leaf extract, and the
like, Exemplary wound-healing agents include, but are not limited
to, Mimosa tenuiflora bark extract, soybean protein, and the like,
Exemplary plumping agents include, but are not limited to,
Saccharomyces/xylinum black tea ferment, Anemarrhena asphodeloides
root extract, sodium hyaluronate, and the like. Exemplary hair
growth retardation agents include, but are not limited to, ursolic
acid, phytosphingosine, Boswella serrata extract, and the like.
Exemplary hair growth stimulating agents include, but are not
limited to, Serenoa serrulata fruit extract, licorice extract,
acetyl glucosamine, and the like. Exemplary dark circle reduction
or de-ptiffying agents include, but are not limited to, hesperidin
methyl chalcone, dipeptide-2, Passiflora incarnate flower extract,
linoleic acid, isolinoleic acid, and the like. Exemplary collagen
synthesis or blood circulation enhancing agents include, but are
not limited to, arginine, Ascophyllum nodosum extract, Asparagopsis
armata extract, caffeine, and the like. Exemplary anti-oxidants
include, but are not limited to, nordihydroguaiaretic acid, grape
seed extract, green tea leaf extract, and the like.
[0021] The skin benefit agents as described hereinabove can be
formulated into an ink formulation that is compatible with the
printing device of the present invention, Such ink formulation may
be an aqueous solution or an oil-in-water emulsion. When all the
skin benefit agents to be delivered are water-soluble, it is
preferred that the ink formulation is aqueous. When some of the
skin benefit agents are oil-soluble, the ink formulation is
preferably a micronized emulsion containing an oil phase in form of
micronized oil droplets dispersed in a continuous aqueous
phase.
[0022] FIG. 1 is a schematic view of a facial mask 10 according to
one embodiment of the present invention. The facial mask 10
contains multiple discrete regions 12, 14, 16, and 18, which are
isolated from one another. Based on the particular skin conditions
of the user, regions 12 are imprinted with at least one sebum
controlling agent for reducing the oiliness at the T-zone section
of the user's face; regions 14 are imprinted with at least one
wrinkle reduction or skin-tightening agent for reducing the fine
lines and wrinkles at the corners of the user's eyes and mouth;
regions 16 are imprinted with at least one dark circle reduction or
de-puffying agent; and region 18 is imprinted with at least one
anti-cellulite agent. Of course, the discrete regions themselves,
may also be customized based on a skin profiling analysis.
Customizations include size, shape and number of discrete regions.
Preferably, but not necessarily, different regions on the mask 10
may be marked with different colors for easy alignment with
different facial features for which the skin benefit agents are
intended. FIG. 2 is a schematic representation of a facial mask 10
according to a second embodiment of the present invention,
[0023] FIG. 3 shows an exploded view of the region 14 of FIG. 1.
Five different types of skin benefit agents are printed thereon,
which include a wrinkle reduction or skin-tightening agent 20, an
anti-aging agent 22, an antioxidant agent 24, a moisturizing agent
26, and a plumping agent 28. These skin benefit agents are
deposited onto the substrate as separate droplets, which are
scattered among one another but without being mixed with one
another. In this manner, such skin benefit agents can provide
simultaneous treatment to the corners of the user's eyes and mouth
with minimum or no interference with one another.
[0024] It will be understood by those skilled in the art that,
while gel cosmetic sheets suitable for use in the present
invention, are naturally tacky, a cosmetic sheet comprised of paper
or a textile may require the presence of a cosmetically acceptable
adhesive layer associated with the first surface of the support to
enhance adherence to the skin. The adhesion of the sheet to the
skin may occur via an adhesive compound associated with the surface
of the sheet or it may be provided in the form of a gel or liquid,
such as water, which moistens the sheet which then clings to skin.
The user may also apply the mask to pre-moistened skin. It also is
contemplated that a consumer could introduce a liquid activator to
the sheet or to specific areas of the sheet which could serve to
aid in adhesion of the sheet to the skin, to activate the
impregnated formulation, or both. The cosmetic sheet may also be
provided with a supporting sheet which can be removed, e.g. peeled
away, before the sheet is applied to the skin.
[0025] The cosmetic sheet may be formed of any thin, porous,
flexible absorbent material, including woven and non-woven fabrics,
including felts, paper, natural fibers, synthetic fibers, elastic
blends or a mixture thereof Non-limiting examples include cotton,
linen, rayon, thermoplastics, and cellulosics. The sheet material
may be a water-soluble material, such as sugar or polysaccharides,
collagen, and water-soluble film-forming polymers. The sheet
material may also comprise a gel, such as a hydrogel, comprised of,
for example, agarose or a water-soluble low-substituted cellulose
ether which may include methyl cellulose, hydroxyethyl cellulose,
hydroxypropyl cellulose, hydroxypropylmethyl cellulose,
hydroxypropylhydroxyethyl cellulose, hydroxyethylmethyl cellulose,
ethyl cellulose, hydroxyethylethyl cellulose, or carboxymethyl
cellulose. Non-woven fabrics are especially preferred from the
viewpoints of cost, productivity and aesthetic feel. Examples of
preferred non-woven materials include, but are not limited to,
natural and synthetic felts, rice paper or cloth, and bamboo cloth.
In a preferred but not necessary embodiment of the present
invention, both the substrate and the skin benefit agents of the
cosmetic sheet are completely water-soluble, such as sugar or
collagen, so upon application of water or like liquid activator,
the cosmetic sheet softens and conforms to the skin, and
subsequently, the entire sheet is absorbed by the skin surface
without having to be removed. Commercially available cosmetic
sheets suitable for practice of the present invention include, for
example, the sugar-based Frosting Sheets from Kopykake (Torrance,
Calif.), the Matricol.RTM. Collagen Sheets from Dr. Suwelack Skin
& Health Care AG (Billerbeck, Germany), and the 3M.TM.
Transparent 2.6 mil Polyethylene Medical Tape 9830.
EXAMPLE 1
Targeted Delivery of Caffeine Power
[0026] An aqueous solution containing caffeine power was prepared
by mixing the following ingredients together:
TABLE-US-00001 Ingredients wt % Deionized water QS Butylene glycol
15.00 Caffeine 5.00 FD&C Blue No. 1 0.04 Phenoxyethanol 0.50
Total 100.00
[0027] The FD&D Blue No. 1 color was provided to mark regions
with caffeine power printed thereon. The aqueous solution as
described hereinabove was placed into a refillable ink cartridge of
an Epson Workforce 30 inkjet printer, which was in turn connected
to a personal computer installed with Photoshop Element 4.0. Three
different types of substrate sheets, including a sugar-based
Frosting Sheet from Kopykake (Torrance, Calif.), a Matricol.RTM.
Collagen Sheet from Dr. Suwelack Skin & Health Care AG
(Billerbeck, Germany), and a 3M.TM. Transparent 2.6 mil
Polyethylene Medical Tape 9830 were fed to the paper tray of the
Epson Workforce 30 inkjet printer, and the caffeine-containing
aqueous solution was successfully printed onto the substrate sheets
by the inkjet printer. The printed substrate sheets were then
applied to the skin of a user for targeted delivery of caffeine as
a skin benefit agent.
EXAMPLE 2
Targeted Delivery of Salicylic Acid
[0028] An aqueous solution containing salicylic acid was prepared
by mixing the following ingredients together:
TABLE-US-00002 Ingredients wt % Deionized water QS Isopentyldiol
40.00 Salicylic acid 1.00 FD&C Yellow No. 5 0.04 Phenoxyethanol
0.50 Total 100.00
[0029] The FD&D Yellow No. 5 color was provided to mark regions
with salicylic acid (SA) printed thereon. The aqueous solution as
described hereinabove was placed into a refillable ink cartridge of
an Epson Workforce 30 inkjet printer, which was in turn connected
to a personal computer installed with Photoshop Element 4.0. Three
different types of substrate sheets, including a sugar-based
Frosting Sheet from Kopykake (Torrance; Calif.), a Matricol.RTM.
Collagen Sheet from Dr. Suwelack Skin & Health Care AG
(Billerbeck, Germany), and a 3M.TM. Transparent 2.6 mil
Polyethylene Medical Tape 9830 were fed to the paper tray of the
Epson Workforce 30 inkjet printer, and the SA-containing aqueous
solution was successfully printed onto the substrate sheets by the
inkjet printer. The printed substrate sheets were then applied to
the skin of a user for targeted delivery of SA as a skin benefit
agent.
[0030] Although the present invention has been described in
accordance with preferred embodiments, it will be understood by
those skilled in the art that various changes and modifications may
be made without departing from the spirit and scope of the
invention.
* * * * *