U.S. patent application number 13/500879 was filed with the patent office on 2012-11-08 for recombinant antibodies against h1n1 influenza. Invention is credited to Rafi Ahmed, Patrick Wilson, Jens Wrammert.
Application Number | 20120282273 13/500879 |
Document ID | / |
Family ID | 43857434 |
Filed Date | 2012-11-08 |
United States Patent Application | 20120282273 |
Kind Code | A1 |
Wrammert; Jens ; et al. | November 8, 2012 |
Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine H1N1 virus. The antibody is also able to cure mice in a therapeutic setting when treated as late as up to 60 hours (2.5 days) after infection with swine H1N1 virus. Also described are recombinant forms of this antibody.
Inventors: | Wrammert; Jens; (Decatur, GA) ; Ahmed; Rafi; (Atlanta, GA) ; Wilson; Patrick; (Chicago, IL) |
Family ID: | 43857434 |
Appl. No.: | 13/500879 |
Filed: | October 12, 2010 |
PCT Filed: | October 12, 2010 |
PCT NO: | PCT/US10/52274 |
371 Date: | June 26, 2012 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
61250479 | Oct 9, 2009 | |||
61260650 | Nov 12, 2009 | |||
Current U.S. Class: | 424/159.1 ; 530/387.3; 530/389.4 |
Current CPC Class: | C07K 2317/76 20130101; C07K 2317/21 20130101; C07K 16/1018 20130101; A61P 31/16 20180101; A61K 2039/505 20130101 |
Class at Publication: | 424/159.1 ; 530/389.4; 530/387.3 |
International Class: | C07K 16/10 20060101 C07K016/10; A61P 31/16 20060101 A61P031/16; A61K 39/42 20060101 A61K039/42 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 46 <210> SEQ ID NO 1 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic polypeptide <400> SEQUENCE: 1 Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp
Arg Val Thr Ile Ser Cys Gln Ala Ser Gln Asp Ile Thr Asn Phe 20 25
30 Leu Asn Trp Tyr Gln Gln Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45 Tyr Asp Ala Ser Asp Leu Glu Thr Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser
Arg Leu Gln Pro 65 70 75 80 Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln
Tyr Asp Asp Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val
Glu Ile Lys 100 105 <210> SEQ ID NO 2 <211> LENGTH: 125
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic polypeptide <400> SEQUENCE: 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Ile
Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu
Asp Trp Val 35 40 45 Ser Ser Ile Ser Ser Arg Gly Asp Tyr Ile Tyr
Tyr Ala Glu Ser Val 50 55 60 Glu Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Gly Leu
Gly Thr Val Asp Leu Arg Trp Gly Gly Ala Phe 100 105 110 Asp His Trp
Gly Lys Gly Ile Leu Val Thr Val Ser Ser 115 120 125 <210> SEQ
ID NO 3 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 3 Gln Ala Ser Gln Asp Ile Thr Asn Phe
Leu Asn 1 5 10 <210> SEQ ID NO 4 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic peptide <400> SEQUENCE: 4 Asp
Ala Ser Asp Leu Glu Thr 1 5 <210> SEQ ID NO 5 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic peptide <400>
SEQUENCE: 5 Gln Gln Tyr Asp Asp Leu Pro Tyr Thr 1 5 <210> SEQ
ID NO 6 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 6 Ile Tyr Ala Met Asn 1 5 <210>
SEQ ID NO 7 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 7 Ser Ile Ser Ser Arg Gly
Asp Tyr Ile Tyr Tyr Ala Glu Ser Val Glu 1 5 10 15 Gly <210>
SEQ ID NO 8 <211> LENGTH: 16 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 8 Ala Gly Leu Gly Thr Val
Asp Leu Arg Trp Gly Gly Ala Phe Asp His 1 5 10 15 <210> SEQ
ID NO 9 <400> SEQUENCE: 9 000 <210> SEQ ID NO 10
<400> SEQUENCE: 10 000 <210> SEQ ID NO 11 <211>
LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic polynucleotide
<400> SEQUENCE: 11 gaggtgcagc tggtggagtc tgggggaggc
ctggtcaagc ctggggggtc cctgagactc 60 tcctgttcag cctctggatt
caccttcaat atctatgcca tgaactgggt ccgccaggtt 120 ccaggaaagg
ggctggattg ggtctcatcc attagtagta ggggtgatta catatactac 180
gcagagtcag tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat
240 ctggaaatga acagcctgag agccgaggac acggctgtgt attactgtgc
gagagctggg 300 ctgggtacag tggatttaag gtgggggggg gccttcgacc
actggggcaa gggaatcctg 360 gtcaccgtct cctca 375 <210> SEQ ID
NO 12 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 12 Arg Ala Gly Leu Gly Thr Val Asp
Leu Arg Trp Gly Gly Ala Phe Asp 1 5 10 15 His <210> SEQ ID NO
13 <211> LENGTH: 376 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
polynucleotide <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(375) <220> FEATURE: <221>
NAME/KEY: modified_base <222> LOCATION: (294)..(333)
<223> OTHER INFORMATION: a, c, t, g, unknown or other
<400> SEQUENCE: 13 gag gtg cag ctg gtg gag tct ggg gga ggc
ctg gtc aag cct ggg ggg 48 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Lys Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttc agt agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 agc atg aac tgg gtc cgc
cag gct cca ggg aag ggg ctg gag tgg gtc 144 Ser Met Asn Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 tca tcc att agt
agt agt agt agt tac ata tac tac gca gac tca gtg 192 Ser Ser Ile Ser
Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 aag ggc
cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat 240 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80
ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt 288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg agn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn
ttc 336 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Phe 100 105 110 gac ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tca
g 376 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
125 <210> SEQ ID NO 14 <211> LENGTH: 125 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (98)..(98) <223>
OTHER INFORMATION: Arg or Ser <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (99)..(111) <223>
OTHER INFORMATION: Any amino acid <400> SEQUENCE: 14 Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe 100 105 110 Asp Pro Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> SEQ ID NO
15 <211> LENGTH: 376 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
polynucleotide <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(375) <400> SEQUENCE: 15 gag gtg
cag ctg gtg gag tct ggg gga ggc ctg gtc aag cct ggg ggg 48 Glu Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15
tcc ctg aga ctc tcc tgt tca gcc tct gga ttc acc ttc aat atc tat 96
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Ile Tyr 20
25 30 gcc atg aac tgg gtc cgc cag gtt cca gga aag ggg ctg gat tgg
gtc 144 Ala Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu Asp Trp
Val 35 40 45 tca tcc att agt agt agg ggt gat tac ata tac tac gca
gag tca gtg 192 Ser Ser Ile Ser Ser Arg Gly Asp Tyr Ile Tyr Tyr Ala
Glu Ser Val 50 55 60 gag ggc cga ttc acc atc tcc aga gac aac gcc
aag aac tca ctg tat 240 Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr 65 70 75 80 ctg gaa atg aac agc ctg aga gcc gag
gac acg gct gtg tat tac tgt 288 Leu Glu Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 gcg aga gct ggg ctg ggt aca
gtg gat tta agg tgg ggg ggg gcc ttc 336 Ala Arg Ala Gly Leu Gly Thr
Val Asp Leu Arg Trp Gly Gly Ala Phe 100 105 110 gac cac tgg ggc aag
gga atc ctg gtc acc gtc tcc tca g 376 Asp His Trp Gly Lys Gly Ile
Leu Val Thr Val Ser Ser 115 120 125 <210> SEQ ID NO 16
<211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
polynucleotide <400> SEQUENCE: 16 gacatccaga tgacccagtc
tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atctcttgcc
aggcgagtca ggatattacc aactttttaa attggtacca gcagaaatct 120
ggggaagccc ctaagctcct gatctacgat gcatccgatt tggaaacagg ggtcccatca
180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag
gctgcagcct 240 gaagacactg caacatatta ctgtcaacag tatgacgatc
tcccgtatac ttttggccag 300 gggaccaagg tggagatcaa a 321 <210>
SEQ ID NO 17 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 17 Gln Tyr Asp Asp Leu Pro
Tyr Thr 1 5 <210> SEQ ID NO 18 <211> LENGTH: 322
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic polynucleotide <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(321)
<220> FEATURE: <221> NAME/KEY: modified_base
<222> LOCATION: (285)..(288) <223> OTHER INFORMATION:
a, c, t, g, unknown or other <400> SEQUENCE: 18 gac atc cag
atg acc cag tct cca tcc tcc ctg tct gca tct gta gga 48 Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 gac
aga gtc acc atc act tgc cag gcg agt cag gac att agc aac tat 96 Asp
Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25
30 tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc
144 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45 tac gat gca tcc aat ttg gaa aca ggg gtc cca tca agg ttc
agt gga 192 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60 agt gga tct ggg aca gat ttt act ttc acc atc agc
agc ctg cag cct 240 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser
Ser Leu Gln Pro 65 70 75 80 gaa gat att gca aca tat tac tgt caa cag
tat gat aat ctc ccn nnn 288 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln
Tyr Asp Asn Leu Pro Xaa 85 90 95 act ttt ggc cag ggg acc aag ctg
gag atc aaa c 322 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
105 <210> SEQ ID NO 19 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic polypeptide <220> FEATURE: <221>
NAME/KEY: MOD_RES <222> LOCATION: (96)..(96) <223>
OTHER INFORMATION: Any amino acid <400> SEQUENCE: 19 Asp Ile
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20
25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile
Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln
Gln Tyr Asp Asn Leu Pro Xaa 85 90 95 Thr Phe Gly Gln Gly Thr Lys
Leu Glu Ile Lys 100 105 <210> SEQ ID NO 20 <211>
LENGTH: 322 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic polynucleotide
<220> FEATURE: <221> NAME/KEY: CDS <222>
LOCATION: (1)..(321) <400> SEQUENCE: 20 gac atc cag atg acc
cag tct cca tcc tcc ctg tct gca tct gtt gga 48 Asp Ile Gln Met Thr
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 gac aga gtc
acc atc tct tgc cag gcg agt cag gat att acc aac ttt 96 Asp Arg Val
Thr Ile Ser Cys Gln Ala Ser Gln Asp Ile Thr Asn Phe 20 25 30 tta
aat tgg tac cag cag aaa tct ggg gaa gcc cct aag ctc ctg atc 144 Leu
Asn Trp Tyr Gln Gln Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile 35 40
45 tac gat gca tcc gat ttg gaa aca ggg gtc cca tca agg ttc agt gga
192 Tyr Asp Ala Ser Asp Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60 agt gga tct ggg aca gat ttt act ttc acc atc agc agg ctg
cag cct 240 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Leu
Gln Pro 65 70 75 80 gaa gac act gca aca tat tac tgt caa cag tat gac
gat ctc ccg tat 288 Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp
Asp Leu Pro Tyr 85 90 95 act ttt ggc cag ggg acc aag gtg gag atc
aaa c 322 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105
<210> SEQ ID NO 21 <211> LENGTH: 90 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide <400> SEQUENCE: 21 gaggtgcagc
tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60
tcctgttcag cctctggatt caccttcaat 90 <210> SEQ ID NO 22
<211> LENGTH: 15 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 22 atctatgcca tgaac 15
<210> SEQ ID NO 23 <211> LENGTH: 42 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide <400> SEQUENCE: 23 tgggtccgcc
aggttccagg aaaggggctg gattgggtct ca 42 <210> SEQ ID NO 24
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 24 tccattagta gtaggggtga
ttacatatac tacgcagagt cagtggaggg c 51 <210> SEQ ID NO 25
<211> LENGTH: 96 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 25 cgattcacca tctccagaga
caacgccaag aactcactgt atctggaaat gaacagcctg 60 agagccgagg
acacggctgt gtattactgt gcgaga 96 <210> SEQ ID NO 26
<211> LENGTH: 48 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 26 gctgggctgg gtacagtgga
tttaaggtgg gggggggcct tcgaccac 48 <210> SEQ ID NO 27
<211> LENGTH: 33 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 27 tggggcaagg gaatcctggt
caccgtctcc tca 33 <210> SEQ ID NO 28 <211> LENGTH: 30
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic polypeptide <400> SEQUENCE: 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn 20 25
30 <210> SEQ ID NO 29 <211> LENGTH: 14 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic peptide <400> SEQUENCE: 29 Trp Val Arg
Gln Val Pro Gly Lys Gly Leu Asp Trp Val Ser 1 5 10 <210> SEQ
ID NO 30 <211> LENGTH: 32 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
polypeptide <400> SEQUENCE: 30 Arg Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr Leu Glu 1 5 10 15 Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210>
SEQ ID NO 31 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 31 Trp Gly Lys Gly Ile Leu
Val Thr Val Ser Ser 1 5 10 <210> SEQ ID NO 32 <211>
LENGTH: 78 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic oligonucleotide
<400> SEQUENCE: 32 gacatccaga tgacccagtc tccatcctcc
ctgtctgcat ctgttggaga cagagtcacc 60 atctcttgcc aggcgagt 78
<210> SEQ ID NO 33 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide <400> SEQUENCE: 33 caggatatta
ccaacttttt aaat 24 <210> SEQ ID NO 34 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 34 tggtaccagc agaaatctgg ggaagcccct aagctcctga tctac 45
<210> SEQ ID NO 35 <211> LENGTH: 21 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide <400> SEQUENCE: 35 gatgcatccg
atttggaaac a 21 <210> SEQ ID NO 36 <211> LENGTH: 96
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 36 ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt
caccatcagc 60 aggctgcagc ctgaagacac tgcaacatat tactgt 96
<210> SEQ ID NO 37 <211> LENGTH: 27 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide <400> SEQUENCE: 37 caacagtatg
acgatctccc gtatact 27 <210> SEQ ID NO 38 <211> LENGTH:
30 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 38 tttggccagg ggaccaaggt ggagatcaaa 30 <210> SEQ ID
NO 39 <211> LENGTH: 23 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 39 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser
Cys 20 <210> SEQ ID NO 40 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic peptide <400> SEQUENCE: 40 Trp Tyr Gln
Gln Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 41 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic polypeptide <400> SEQUENCE: 41 Gly Val Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Phe Thr Ile
Ser Arg Leu Gln Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 20 25 30
<210> SEQ ID NO 42 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 42 Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys 1 5 10 <210> SEQ ID NO 43 <211> LENGTH:
330 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 43 Arg Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210
215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> SEQ ID NO
44 <211> LENGTH: 5746 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 44 ttcgagctcg
cccgacattg attattgact agttattaat agtaatcaat tacggggtca 60
ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct
120 ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt
tcccatagta 180 acgccaatag ggactttcca ttgacgtcaa tgggtggagt
atttacggta aactgcccac 240 ttggcagtac atcaagtgta tcatatgcca
agtacgcccc ctattgacgt caatgacggt 300 aaatggcccg cctggcatta
tgcccagtac atgaccttat gggactttcc tacttggcag 360 tacatctacg
tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat 420
gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat
480 gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa
caactccgcc 540 ccattgacgc aaatgggcgg taggcgtgta cggtgggagg
tctatataag cagagctcgt 600 ttagtgaacc gtcagatcgc ctggagacgc
catccacgct gttttgacct ccatagaaga 660 caccgggacc gatccagcct
ccgcggccgg gaacggtgca ttggaacgcg gattccccgt 720 gccaagagtg
acgtaagtac cgcctataga gtctataggc ccaccccctt ggcttcgtta 780
gaacgcggct acaattaata cataacctta tgtatcatac acatacgatt taggtgacac
840 tatagaataa catccacttt gcctttctct ccacaggtgt ccactcccag
gtccaactgc 900 acctcggttc tatcgattga attccaccat gggatggtca
tgtatcatcc tttttctagt 960 agcaactgca accggtgtac actcgagcgt
acggtcgacc aagggcccat cggtcttccc 1020 cctggcaccc tcctccaaga
gcacctctgg gggcacagcg gccctgggct gcctggtcaa 1080 ggactacttc
cccgaacctg tgacggtctc gtggaactca ggcgccctga ccagcggcgt 1140
gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac
1200 cgtgccctcc agcagcttgg gcacccagac ctacatctgc aacgtgaatc
acaagcccag 1260 caacaccaag gtggacaaga aagttgagcc caaatcttgt
gacaaaactc acacatgccc 1320 accgtgccca gcacctgaac tcctgggggg
accgtcagtc ttcctcttcc ccccaaaacc 1380 caaggacacc ctcatgatct
cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag 1440 ccacgaagac
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc 1500
caagacaaag ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac
1560 cgtcctgcac caggactggc tgaatggcaa ggagtacaag tgcaaggtct
ccaacaaagc 1620 cctcccagcc cccatcgaga aaaccatctc caaagccaaa
gggcagcccc gagaaccaca 1680 ggtgtacacc ctgcccccat cccgggatga
gctgaccaag aaccaggtca gcctgacctg 1740 cctggtcaaa ggcttctatc
ccagcgacat cgccgtggag tgggagagca atgggcagcc 1800 ggagaacaac
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta 1860
cagcaagctc accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt
1920 gatgcatgag gctctgcaca accactacac gcagaagagc ctctccctgt
ctccgggtaa 1980 atgaagcttg gccgccatgg cccaacttgt ttattgcagc
ttataatggt tacaaataaa 2040 gcaatagcat cacaaatttc acaaataaag
catttttttc actgcattct agttgtggtt 2100 tgtccaaact catcaatgta
tcttatcatg tctggatcga tcgggaatta attcggcgca 2160 gcaccatggc
ctgaaataac ctctgaaaga ggaacttggt taggtacctt ctgaggcgga 2220
aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca
2280 ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg
aaagtcccca 2340 ggctccccag caggcagaag tatgcaaagc atgcatctca
attagtcagc aaccatagtc 2400 ccgcccctaa ctccgcccat cccgccccta
actccgccca gttccgccca ttctccgccc 2460 catggctgac taattttttt
tatttatgca gaggccgagg ccgcctcggc ctctgagcta 2520 ttccagaagt
agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctgttaaca 2580
gcttggcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac
2640 ttaatcgcct tgcagcacat ccccccttcg ccagctggcg taatagcgaa
gaggcccgca 2700 ccgatcgccc ttcccaacag ttgcgtagcc tgaatggcga
atggcgcctg atgcggtatt 2760 ttctccttac gcatctgtgc ggtatttcac
accgcatacg tcaaagcaac catagtacgc 2820 gccctgtagc ggcgcattaa
gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac 2880 acttgccagc
gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt 2940
cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc
3000 tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta
gtgggccatc 3060 gccctgatag acggtttttc gccctttgac gttggagtcc
acgttcttta atagtggact 3120 cttgttccaa actggaacaa cactcaaccc
tatctcgggc tattcttttg atttataagg 3180 gattttgccg atttcggcct
attggttaaa aaatgagctg atttaacaaa aatttaacgc 3240 gaattttaac
aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc 3300
tgatgccgca tagttaagcc aactccgcta tcgctacgtg actgggtcat ggctgcgccc
3360 cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc
ggcatccgct 3420 tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc
agaggttttc accgtcatca 3480 ccgaaacgcg cgaggcagta ttcttgaaga
cgaaagggcc tcgtgatacg cctattttta 3540 taggttaatg tcatgataat
aatggtttct tagacgtcag gtggcacttt tcggggaaat 3600 gtgcgcggaa
cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 3660
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa
3720 catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt
ttttgctcac 3780 ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt
tgggtgcacg agtgggttac 3840 atcgaactgg atctcaacag cggtaagatc
cttgagagtt ttcgccccga agaacgtttt 3900 ccaatgatga gcacttttaa
agttctgcta tgtggcgcgg tattatcccg tgatgacgcc 3960 gggcaagagc
aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 4020
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc
4080 ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg
aggaccgaag 4140 gagctaaccg cttttttgca caacatgggg gatcatgtaa
ctcgccttga tcgttgggaa 4200 ccggagctga atgaagccat accaaacgac
gagcgtgaca ccacgatgcc agcagcaatg 4260 gcaacaacgt tgcgcaaact
attaactggc gaactactta ctctagcttc ccggcaacaa 4320 ttaatagact
ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 4380
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt
4440 gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac
gacggggagt 4500 caggcaacta tggatgaacg aaatagacag atcgctgaga
taggtgcctc actgattaag 4560 cattggtaac tgtcagacca agtttactca
tatatacttt agattgattt aaaacttcat 4620 ttttaattta aaaggatcta
ggtgaagatc ctttttgata atctcatgac caaaatccct 4680 taacgtgagt
tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 4740
tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca
4800 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt
aactggcttc 4860 agcagagcgc agataccaaa tactgtcctt ctagtgtagc
cgtagttagg ccaccacttc 4920 aagaactctg tagcaccgcc tacatacctc
gctctgctaa tcctgttacc agtggctgct 4980 gccagtggcg ataagtcgtg
tcttaccggg ttggactcaa gacgatagtt accggataag 5040 gcgcagcggt
cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 5100
tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg
5160 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg
cacgagggag 5220 cttccagggg gaaacgcctg gtatctttat agtcctgtcg
ggtttcgcca cctctgactt 5280 gagcgtcgat ttttgtgatg ctcgtcaggg
gggcggagcc tatggaaaaa cgccagcaac 5340 gcggcctttt tacggttcct
ggccttttgc tggccttttg ctcacatgtt ctttcctgcg 5400 ttatcccctg
attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc 5460
cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata
5520 cgcaaaccgc ctctccccgc gcgttggccg attcattaat ccagctggca
cgacaggttt 5580 cccgactgga aagcgggcag tgagcgcaac gcaattaatg
tgagttacct cactcattag 5640 gcaccccagg ctttacactt tatgcttccg
gctcgtatgt tgtgtggaat tgtgagcgga 5700 taacaatttc acacaggaaa
cagctatgac catgattacg aattaa 5746 <210> SEQ ID NO 45
<211> LENGTH: 286 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 45 Met Ser Ile Gln His Phe Arg
Val Ala Leu Ile Pro Phe Phe Ala Ala 1 5 10 15 Phe Cys Leu Pro Val
Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 20 25 30 Asp Ala Glu
Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 35 40 45 Leu
Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 50 55
60 Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser
65 70 75 80 Arg Asp Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His
Tyr Ser 85 90 95 Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu
Lys His Leu Thr 100 105 110 Asp Gly Met Thr Val Arg Glu Leu Cys Ser
Ala Ala Ile Thr Met Ser 115 120 125 Asp Asn Thr Ala Ala Asn Leu Leu
Leu Thr Thr Ile Gly Gly Pro Lys 130 135 140 Glu Leu Thr Ala Phe Leu
His Asn Met Gly Asp His Val Thr Arg Leu 145 150 155 160 Asp Arg Trp
Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 165 170 175 Asp
Thr Thr Met Pro Ala Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 180 185
190 Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp
195 200 205 Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala
Leu Pro 210 215 220 Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly
Glu Arg Gly Ser 225 230 235 240 Arg Gly Ile Ile Ala Ala Leu Gly Pro
Asp Gly Lys Pro Ser Arg Ile 245 250 255 Val Val Ile Tyr Thr Thr Gly
Ser Gln Ala Thr Met Asp Glu Arg Asn 260 265 270 Arg Gln Ile Ala Glu
Ile Gly Ala Ser Leu Ile Lys His Trp 275 280 285 <210> SEQ ID
NO 46 <211> LENGTH: 5074 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 46 ttcgagctcg
cccgacattg attattgact agttattaat agtaatcaat tacggggtca 60
ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct
120 ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt
tcccatagta 180 acgccaatag ggactttcca ttgacgtcaa tgggtggagt
atttacggta aactgcccac 240 ttggcagtac atcaagtgta tcatatgcca
agtacgcccc ctattgacgt caatgacggt 300 aaatggcccg cctggcatta
tgcccagtac atgaccttat gggactttcc tacttggcag 360 tacatctacg
tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat 420
gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat
480 gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa
caactccgcc 540 ccattgacgc aaatgggcgg taggcgtgta cggtgggagg
tctatataag cagagctcgt 600 ttagtgaacc gtcagatcgc ctggagacgc
catccacgct gttttgacct ccatagaaga 660 caccgggacc gatccagcct
ccgcggccgg gaacggtgca ttggaacgcg gattccccgt 720 gccaagagtg
acgtaagtac cgcctataga gtctataggc ccaccccctt ggcttcgtta 780
gaacgcggct acaattaata cataacctta tgtatcatac acatacgatt taggtgacac
840 tatagaataa catccacttt gcctttctct ccacaggtgt ccactcccag
gtccaactgc 900 acctcggttc tatcgattga attccaccat gggatggtca
tgtatcatcc tttttctagt 960 agcaactgca accggtgtac actcgagcgt
acggtggctg caccatctgt cttcatcttc 1020 ccgccatctg atgagcagtt
gaaatctgga actgcctctg ttgtgtgcct gctgaataac 1080 ttctatccca
gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 1140
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc
1200 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga
agtcacccat 1260 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg
gagagtgtta gaagcttggc 1320 cgccatggcc caacttgttt attgcagctt
ataatggtta caaataaagc aatagcatca 1380 caaatttcac aaataaagca
tttttttcac tgcattctag ttgtggtttg tccaaactca 1440 tcaatgtatc
ttatcatgtc tggatcgatc gggaattaat tcggcgcagc accatggcct 1500
gaaataacct ctgaaagagg aacttggtta ggtaccttct gaggcggaaa gaaccagctg
1560 tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg
cagaagtatg 1620 caaagcatgc atctcaatta gtcagcaacc aggtgtggaa
agtccccagg ctccccagca 1680 ggcagaagta tgcaaagcat gcatctcaat
tagtcagcaa ccatagtccc gcccctaact 1740 ccgcccatcc cgcccctaac
tccgcccagt tccgcccatt ctccgcccca tggctgacta 1800 atttttttta
tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 1860
tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tgttaacagc ttggcactgg
1920 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt
aatcgccttg 1980 cagcacatcc ccccttcgcc agctggcgta atagcgaaga
ggcccgcacc gatcgccctt 2040 cccaacagtt gcgtagcctg aatggcgaat
ggcgcctgat gcggtatttt ctccttacgc 2100 atctgtgcgg tatttcacac
cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 2160 cgcattaagc
gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 2220
cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc
2280 ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt
tacggcacct 2340 cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt
gggccatcgc cctgatagac 2400 ggtttttcgc cctttgacgt tggagtccac
gttctttaat agtggactct tgttccaaac 2460 tggaacaaca ctcaacccta
tctcgggcta ttcttttgat ttataaggga ttttgccgat 2520 ttcggcctat
tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa 2580
aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata
2640 gttaagccaa ctccgctatc gctacgtgac tgggtcatgg ctgcgccccg
acacccgcca 2700 acacccgctg acgcgccctg acgggcttgt ctgctcccgg
catccgctta cagacaagct 2760 gtgaccgtct ccgggagctg catgtgtcag
aggttttcac cgtcatcacc gaaacgcgcg 2820 aggcagtatt cttgaagacg
aaagggcctc gtgatacgcc tatttttata ggttaatgtc 2880 atgataataa
tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc 2940
cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc
3000 tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca
tttccgtgtc 3060 gcccttattc ccttttttgc ggcattttgc cttcctgttt
ttgctcaccc agaaacgctg 3120 gtgaaagtaa aagatgctga agatcagttg
ggtgcacgag tgggttacat cgaactggat 3180 ctcaacagcg gtaagatcct
tgagagtttt cgccccgaag aacgttttcc aatgatgagc 3240 acttttaaag
ttctgctatg tggcgcggta ttatcccgtg atgacgccgg gcaagagcaa 3300
ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa
3360 aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat
aaccatgagt 3420 gataacactg cggccaactt acttctgaca acgatcggag
gaccgaagga gctaaccgct 3480 tttttgcaca acatggggga tcatgtaact
cgccttgatc gttgggaacc ggagctgaat 3540 gaagccatac caaacgacga
gcgtgacacc acgatgccag cagcaatggc aacaacgttg 3600 cgcaaactat
taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg 3660
atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt
3720 attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc
agcactgggg 3780 ccagatggta agccctcccg tatcgtagtt atctacacga
cggggagtca ggcaactatg 3840 gatgaacgaa atagacagat cgctgagata
ggtgcctcac tgattaagca ttggtaactg 3900 tcagaccaag tttactcata
tatactttag attgatttaa aacttcattt ttaatttaaa 3960 aggatctagg
tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt 4020
tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt
4080 tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc
ggtggtttgt 4140 ttgccggatc aagagctacc aactcttttt ccgaaggtaa
ctggcttcag cagagcgcag 4200 ataccaaata ctgtccttct agtgtagccg
tagttaggcc accacttcaa gaactctgta 4260 gcaccgccta catacctcgc
tctgctaatc ctgttaccag tggctgctgc cagtggcgat 4320 aagtcgtgtc
ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg 4380
ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg
4440 agatacctac agcgtgagca ttgagaaagc gccacgcttc ccgaagggag
aaaggcggac 4500 aggtatccgg taagcggcag ggtcggaaca ggagagcgca
cgagggagct tccaggggga 4560 aacgcctggt atctttatag tcctgtcggg
tttcgccacc tctgacttga gcgtcgattt 4620 ttgtgatgct cgtcaggggg
gcggagccta tggaaaaacg ccagcaacgc ggccttttta 4680 cggttcctgg
ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat 4740
tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg
4800 accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg
caaaccgcct 4860 ctccccgcgc gttggccgat tcattaatcc agctggcacg
acaggtttcc cgactggaaa 4920 gcgggcagtg agcgcaacgc aattaatgtg
agttacctca ctcattaggc accccaggct 4980 ttacacttta tgcttccggc
tcgtatgttg tgtggaattg tgagcggata acaatttcac 5040 acaggaaaca
gctatgacca tgattacgaa ttaa 5074
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 46 <210>
SEQ ID NO 1 <211> LENGTH: 107 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic polypeptide <400> SEQUENCE: 1 Asp Ile Gln Met Thr
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val
Thr Ile Ser Cys Gln Ala Ser Gln Asp Ile Thr Asn Phe 20 25 30 Leu
Asn Trp Tyr Gln Gln Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile 35 40
45 Tyr Asp Ala Ser Asp Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Leu
Gln Pro 65 70 75 80 Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp
Asp Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
Lys 100 105 <210> SEQ ID NO 2 <211> LENGTH: 125
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic polypeptide <400> SEQUENCE: 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Ile
Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu
Asp Trp Val 35 40 45 Ser Ser Ile Ser Ser Arg Gly Asp Tyr Ile Tyr
Tyr Ala Glu Ser Val 50 55 60 Glu Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Gly Leu
Gly Thr Val Asp Leu Arg Trp Gly Gly Ala Phe 100 105 110 Asp His Trp
Gly Lys Gly Ile Leu Val Thr Val Ser Ser 115 120 125 <210> SEQ
ID NO 3 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 3 Gln Ala Ser Gln Asp Ile Thr Asn Phe
Leu Asn 1 5 10 <210> SEQ ID NO 4 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic peptide <400> SEQUENCE: 4 Asp
Ala Ser Asp Leu Glu Thr 1 5 <210> SEQ ID NO 5 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic peptide <400>
SEQUENCE: 5 Gln Gln Tyr Asp Asp Leu Pro Tyr Thr 1 5 <210> SEQ
ID NO 6 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 6 Ile Tyr Ala Met Asn 1 5 <210>
SEQ ID NO 7 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 7 Ser Ile Ser Ser Arg Gly
Asp Tyr Ile Tyr Tyr Ala Glu Ser Val Glu 1 5 10 15 Gly <210>
SEQ ID NO 8 <211> LENGTH: 16 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 8 Ala Gly Leu Gly Thr Val
Asp Leu Arg Trp Gly Gly Ala Phe Asp His 1 5 10 15 <210> SEQ
ID NO 9 <400> SEQUENCE: 9 000 <210> SEQ ID NO 10
<400> SEQUENCE: 10 000 <210> SEQ ID NO 11 <211>
LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic polynucleotide
<400> SEQUENCE: 11 gaggtgcagc tggtggagtc tgggggaggc
ctggtcaagc ctggggggtc cctgagactc 60 tcctgttcag cctctggatt
caccttcaat atctatgcca tgaactgggt ccgccaggtt 120 ccaggaaagg
ggctggattg ggtctcatcc attagtagta ggggtgatta catatactac 180
gcagagtcag tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat
240 ctggaaatga acagcctgag agccgaggac acggctgtgt attactgtgc
gagagctggg 300 ctgggtacag tggatttaag gtgggggggg gccttcgacc
actggggcaa gggaatcctg 360 gtcaccgtct cctca 375 <210> SEQ ID
NO 12 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 12 Arg Ala Gly Leu Gly Thr Val Asp
Leu Arg Trp Gly Gly Ala Phe Asp 1 5 10 15 His <210> SEQ ID NO
13 <211> LENGTH: 376 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
polynucleotide <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(375) <220> FEATURE: <221>
NAME/KEY: modified_base <222> LOCATION: (294)..(333)
<223> OTHER INFORMATION: a, c, t, g, unknown or other
<400> SEQUENCE: 13 gag gtg cag ctg gtg gag tct ggg gga ggc
ctg gtc aag cct ggg ggg 48 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Lys Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt gca gcc
tct gga ttc acc ttc agt agc tat 96 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30
agc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc 144
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 tca tcc att agt agt agt agt agt tac ata tac tac gca gac tca
gtg 192 Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser
Val 50 55 60 aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac
tca ctg tat 240 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 65 70 75 80 ctg caa atg aac agc ctg aga gcc gag gac acg
gct gtg tat tac tgt 288 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 gcg agn nnn nnn nnn nnn nnn nnn nnn
nnn nnn nnn nnn nnn nnn ttc 336 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Phe 100 105 110 gac ccc tgg ggc cag gga acc
ctg gtc acc gtc tcc tca g 376 Asp Pro Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser 115 120 125 <210> SEQ ID NO 14 <211>
LENGTH: 125 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic polypeptide
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (98)..(98) <223> OTHER INFORMATION: Arg or Ser
<220> FEATURE: <221> NAME/KEY: MOD_RES <222>
LOCATION: (99)..(111) <223> OTHER INFORMATION: Any amino acid
<400> SEQUENCE: 14 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Asn Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Phe 100 105 110 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125 <210> SEQ ID NO 15 <211> LENGTH: 376
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic polynucleotide <220> FEATURE:
<221> NAME/KEY: CDS <222> LOCATION: (1)..(375)
<400> SEQUENCE: 15 gag gtg cag ctg gtg gag tct ggg gga ggc
ctg gtc aag cct ggg ggg 48 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Lys Pro Gly Gly 1 5 10 15 tcc ctg aga ctc tcc tgt tca gcc
tct gga ttc acc ttc aat atc tat 96 Ser Leu Arg Leu Ser Cys Ser Ala
Ser Gly Phe Thr Phe Asn Ile Tyr 20 25 30 gcc atg aac tgg gtc cgc
cag gtt cca gga aag ggg ctg gat tgg gtc 144 Ala Met Asn Trp Val Arg
Gln Val Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 tca tcc att agt
agt agg ggt gat tac ata tac tac gca gag tca gtg 192 Ser Ser Ile Ser
Ser Arg Gly Asp Tyr Ile Tyr Tyr Ala Glu Ser Val 50 55 60 gag ggc
cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat 240 Glu Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80
ctg gaa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt 288
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 gcg aga gct ggg ctg ggt aca gtg gat tta agg tgg ggg ggg gcc
ttc 336 Ala Arg Ala Gly Leu Gly Thr Val Asp Leu Arg Trp Gly Gly Ala
Phe 100 105 110 gac cac tgg ggc aag gga atc ctg gtc acc gtc tcc tca
g 376 Asp His Trp Gly Lys Gly Ile Leu Val Thr Val Ser Ser 115 120
125 <210> SEQ ID NO 16 <211> LENGTH: 321 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic polynucleotide <400> SEQUENCE: 16
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc
60 atctcttgcc aggcgagtca ggatattacc aactttttaa attggtacca
gcagaaatct 120 ggggaagccc ctaagctcct gatctacgat gcatccgatt
tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat
tttactttca ccatcagcag gctgcagcct 240 gaagacactg caacatatta
ctgtcaacag tatgacgatc tcccgtatac ttttggccag 300 gggaccaagg
tggagatcaa a 321 <210> SEQ ID NO 17 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic peptide <400> SEQUENCE: 17 Gln
Tyr Asp Asp Leu Pro Tyr Thr 1 5 <210> SEQ ID NO 18
<211> LENGTH: 322 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
polynucleotide <220> FEATURE: <221> NAME/KEY: CDS
<222> LOCATION: (1)..(321) <220> FEATURE: <221>
NAME/KEY: modified_base <222> LOCATION: (285)..(288)
<223> OTHER INFORMATION: a, c, t, g, unknown or other
<400> SEQUENCE: 18 gac atc cag atg acc cag tct cca tcc tcc
ctg tct gca tct gta gga 48 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 gac aga gtc acc atc act tgc cag
gcg agt cag gac att agc aac tat 96 Asp Arg Val Thr Ile Thr Cys Gln
Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 tta aat tgg tat cag cag
aaa cca ggg aaa gcc cct aag ctc ctg atc 144 Leu Asn Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 tac gat gca tcc
aat ttg gaa aca ggg gtc cca tca agg ttc agt gga 192 Tyr Asp Ala Ser
Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 agt gga
tct ggg aca gat ttt act ttc acc atc agc agc ctg cag cct 240 Ser Gly
Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
gaa gat att gca aca tat tac tgt caa cag tat gat aat ctc ccn nnn 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Xaa 85
90 95 act ttt ggc cag ggg acc aag ctg gag atc aaa c 322 Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> SEQ ID NO 19
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
polypeptide <220> FEATURE: <221> NAME/KEY: MOD_RES
<222> LOCATION: (96)..(96) <223> OTHER INFORMATION: Any
amino acid <400> SEQUENCE: 19 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp
Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65
70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu
Pro Xaa 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
105 <210> SEQ ID NO 20 <211> LENGTH: 322 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic polynucleotide <220> FEATURE: <221>
NAME/KEY: CDS <222> LOCATION: (1)..(321)
<400> SEQUENCE: 20 gac atc cag atg acc cag tct cca tcc tcc
ctg tct gca tct gtt gga 48 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 gac aga gtc acc atc tct tgc cag
gcg agt cag gat att acc aac ttt 96 Asp Arg Val Thr Ile Ser Cys Gln
Ala Ser Gln Asp Ile Thr Asn Phe 20 25 30 tta aat tgg tac cag cag
aaa tct ggg gaa gcc cct aag ctc ctg atc 144 Leu Asn Trp Tyr Gln Gln
Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile 35 40 45 tac gat gca tcc
gat ttg gaa aca ggg gtc cca tca agg ttc agt gga 192 Tyr Asp Ala Ser
Asp Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 agt gga
tct ggg aca gat ttt act ttc acc atc agc agg ctg cag cct 240 Ser Gly
Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Leu Gln Pro 65 70 75 80
gaa gac act gca aca tat tac tgt caa cag tat gac gat ctc ccg tat 288
Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Tyr 85
90 95 act ttt ggc cag ggg acc aag gtg gag atc aaa c 322 Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> SEQ ID NO 21
<211> LENGTH: 90 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 21 gaggtgcagc tggtggagtc
tgggggaggc ctggtcaagc ctggggggtc cctgagactc 60 tcctgttcag
cctctggatt caccttcaat 90 <210> SEQ ID NO 22 <211>
LENGTH: 15 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic oligonucleotide
<400> SEQUENCE: 22 atctatgcca tgaac 15 <210> SEQ ID NO
23 <211> LENGTH: 42 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 23 tgggtccgcc aggttccagg
aaaggggctg gattgggtct ca 42 <210> SEQ ID NO 24 <211>
LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic oligonucleotide
<400> SEQUENCE: 24 tccattagta gtaggggtga ttacatatac
tacgcagagt cagtggaggg c 51 <210> SEQ ID NO 25 <211>
LENGTH: 96 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic oligonucleotide
<400> SEQUENCE: 25 cgattcacca tctccagaga caacgccaag
aactcactgt atctggaaat gaacagcctg 60 agagccgagg acacggctgt
gtattactgt gcgaga 96 <210> SEQ ID NO 26 <211> LENGTH:
48 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 26 gctgggctgg gtacagtgga tttaaggtgg gggggggcct tcgaccac
48 <210> SEQ ID NO 27 <211> LENGTH: 33 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic oligonucleotide <400> SEQUENCE: 27
tggggcaagg gaatcctggt caccgtctcc tca 33 <210> SEQ ID NO 28
<211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
polypeptide <400> SEQUENCE: 28 Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser
Cys Ser Ala Ser Gly Phe Thr Phe Asn 20 25 30 <210> SEQ ID NO
29 <211> LENGTH: 14 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 29 Trp Val Arg Gln Val Pro Gly Lys
Gly Leu Asp Trp Val Ser 1 5 10 <210> SEQ ID NO 30 <211>
LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Synthetic polypeptide
<400> SEQUENCE: 30 Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser Leu Tyr Leu Glu 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> SEQ ID NO 31
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic peptide
<400> SEQUENCE: 31 Trp Gly Lys Gly Ile Leu Val Thr Val Ser
Ser 1 5 10 <210> SEQ ID NO 32 <211> LENGTH: 78
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 32 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga
cagagtcacc 60 atctcttgcc aggcgagt 78 <210> SEQ ID NO 33
<211> LENGTH: 24 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 33 caggatatta ccaacttttt aaat
24 <210> SEQ ID NO 34 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic oligonucleotide <400> SEQUENCE: 34
tggtaccagc agaaatctgg ggaagcccct aagctcctga tctac 45 <210>
SEQ ID NO 35 <211> LENGTH: 21 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic oligonucleotide
<400> SEQUENCE: 35 gatgcatccg atttggaaac a 21 <210> SEQ
ID NO 36 <211> LENGTH: 96 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 36 ggggtcccat caaggttcag
tggaagtgga tctgggacag attttacttt caccatcagc 60 aggctgcagc
ctgaagacac tgcaacatat tactgt 96 <210> SEQ ID NO 37
<211> LENGTH: 27 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Synthetic
oligonucleotide <400> SEQUENCE: 37 caacagtatg acgatctccc
gtatact 27 <210> SEQ ID NO 38 <211> LENGTH: 30
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Synthetic oligonucleotide <400>
SEQUENCE: 38 tttggccagg ggaccaaggt ggagatcaaa 30 <210> SEQ ID
NO 39 <211> LENGTH: 23 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Synthetic
peptide <400> SEQUENCE: 39 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser
Cys 20 <210> SEQ ID NO 40 <211> LENGTH: 15 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Description of Artificial
Sequence: Synthetic peptide <400> SEQUENCE: 40 Trp Tyr Gln
Gln Lys Ser Gly Glu Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15
<210> SEQ ID NO 41 <211> LENGTH: 32 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic polypeptide <400> SEQUENCE: 41 Gly Val Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Phe Thr Ile
Ser Arg Leu Gln Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 20 25 30
<210> SEQ ID NO 42 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Synthetic peptide <400> SEQUENCE: 42 Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys 1 5 10 <210> SEQ ID NO 43 <211> LENGTH:
330 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 43 Arg Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210
215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> SEQ ID NO
44 <211> LENGTH: 5746 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 44 ttcgagctcg
cccgacattg attattgact agttattaat agtaatcaat tacggggtca 60
ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct
120 ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt
tcccatagta 180 acgccaatag ggactttcca ttgacgtcaa tgggtggagt
atttacggta aactgcccac 240 ttggcagtac atcaagtgta tcatatgcca
agtacgcccc ctattgacgt caatgacggt 300 aaatggcccg cctggcatta
tgcccagtac atgaccttat gggactttcc tacttggcag 360 tacatctacg
tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat 420
gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat
480 gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa
caactccgcc 540 ccattgacgc aaatgggcgg taggcgtgta cggtgggagg
tctatataag cagagctcgt 600 ttagtgaacc gtcagatcgc ctggagacgc
catccacgct gttttgacct ccatagaaga 660 caccgggacc gatccagcct
ccgcggccgg gaacggtgca ttggaacgcg gattccccgt 720 gccaagagtg
acgtaagtac cgcctataga gtctataggc ccaccccctt ggcttcgtta 780
gaacgcggct acaattaata cataacctta tgtatcatac acatacgatt taggtgacac
840 tatagaataa catccacttt gcctttctct ccacaggtgt ccactcccag
gtccaactgc 900 acctcggttc tatcgattga attccaccat gggatggtca
tgtatcatcc tttttctagt 960 agcaactgca accggtgtac actcgagcgt
acggtcgacc aagggcccat cggtcttccc 1020 cctggcaccc tcctccaaga
gcacctctgg gggcacagcg gccctgggct gcctggtcaa 1080 ggactacttc
cccgaacctg tgacggtctc gtggaactca ggcgccctga ccagcggcgt 1140
gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac
1200 cgtgccctcc agcagcttgg gcacccagac ctacatctgc aacgtgaatc
acaagcccag 1260 caacaccaag gtggacaaga aagttgagcc caaatcttgt
gacaaaactc acacatgccc 1320 accgtgccca gcacctgaac tcctgggggg
accgtcagtc ttcctcttcc ccccaaaacc 1380 caaggacacc ctcatgatct
cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag 1440 ccacgaagac
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc 1500
caagacaaag ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac
1560 cgtcctgcac caggactggc tgaatggcaa ggagtacaag tgcaaggtct
ccaacaaagc 1620 cctcccagcc cccatcgaga aaaccatctc caaagccaaa
gggcagcccc gagaaccaca 1680 ggtgtacacc ctgcccccat cccgggatga
gctgaccaag aaccaggtca gcctgacctg 1740
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
1800 ggagaacaac tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta 1860 cagcaagctc accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt 1920 gatgcatgag gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa 1980 atgaagcttg gccgccatgg
cccaacttgt ttattgcagc ttataatggt tacaaataaa 2040 gcaatagcat
cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 2100
tgtccaaact catcaatgta tcttatcatg tctggatcga tcgggaatta attcggcgca
2160 gcaccatggc ctgaaataac ctctgaaaga ggaacttggt taggtacctt
ctgaggcgga 2220 aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa
agtccccagg ctccccagca 2280 ggcagaagta tgcaaagcat gcatctcaat
tagtcagcaa ccaggtgtgg aaagtcccca 2340 ggctccccag caggcagaag
tatgcaaagc atgcatctca attagtcagc aaccatagtc 2400 ccgcccctaa
ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 2460
catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta
2520 ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa
gctgttaaca 2580 gcttggcact ggccgtcgtt ttacaacgtc gtgactggga
aaaccctggc gttacccaac 2640 ttaatcgcct tgcagcacat ccccccttcg
ccagctggcg taatagcgaa gaggcccgca 2700 ccgatcgccc ttcccaacag
ttgcgtagcc tgaatggcga atggcgcctg atgcggtatt 2760 ttctccttac
gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc 2820
gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac
2880 acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc
tcgccacgtt 2940 cgccggcttt ccccgtcaag ctctaaatcg ggggctccct
ttagggttcc gatttagtgc 3000 tttacggcac ctcgacccca aaaaacttga
tttgggtgat ggttcacgta gtgggccatc 3060 gccctgatag acggtttttc
gccctttgac gttggagtcc acgttcttta atagtggact 3120 cttgttccaa
actggaacaa cactcaaccc tatctcgggc tattcttttg atttataagg 3180
gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc
3240 gaattttaac aaaatattaa cgtttacaat tttatggtgc actctcagta
caatctgctc 3300 tgatgccgca tagttaagcc aactccgcta tcgctacgtg
actgggtcat ggctgcgccc 3360 cgacacccgc caacacccgc tgacgcgccc
tgacgggctt gtctgctccc ggcatccgct 3420 tacagacaag ctgtgaccgt
ctccgggagc tgcatgtgtc agaggttttc accgtcatca 3480 ccgaaacgcg
cgaggcagta ttcttgaaga cgaaagggcc tcgtgatacg cctattttta 3540
taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat
3600 gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta
tccgctcatg 3660 agacaataac cctgataaat gcttcaataa tattgaaaaa
ggaagagtat gagtattcaa 3720 catttccgtg tcgcccttat tccctttttt
gcggcatttt gccttcctgt ttttgctcac 3780 ccagaaacgc tggtgaaagt
aaaagatgct gaagatcagt tgggtgcacg agtgggttac 3840 atcgaactgg
atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 3900
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgatgacgcc
3960 gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt
tgagtactca 4020 ccagtcacag aaaagcatct tacggatggc atgacagtaa
gagaattatg cagtgctgcc 4080 ataaccatga gtgataacac tgcggccaac
ttacttctga caacgatcgg aggaccgaag 4140 gagctaaccg cttttttgca
caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 4200 ccggagctga
atgaagccat accaaacgac gagcgtgaca ccacgatgcc agcagcaatg 4260
gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa
4320 ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc
ggcccttccg 4380 gctggctggt ttattgctga taaatctgga gccggtgagc
gtgggtctcg cggtatcatt 4440 gcagcactgg ggccagatgg taagccctcc
cgtatcgtag ttatctacac gacggggagt 4500 caggcaacta tggatgaacg
aaatagacag atcgctgaga taggtgcctc actgattaag 4560 cattggtaac
tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 4620
ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct
4680 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa
aggatcttct 4740 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa
caaaaaaacc accgctacca 4800 gcggtggttt gtttgccgga tcaagagcta
ccaactcttt ttccgaaggt aactggcttc 4860 agcagagcgc agataccaaa
tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 4920 aagaactctg
tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 4980
gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag
5040 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga
gcgaacgacc 5100 tacaccgaac tgagatacct acagcgtgag cattgagaaa
gcgccacgct tcccgaaggg 5160 agaaaggcgg acaggtatcc ggtaagcggc
agggtcggaa caggagagcg cacgagggag 5220 cttccagggg gaaacgcctg
gtatctttat agtcctgtcg ggtttcgcca cctctgactt 5280 gagcgtcgat
ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 5340
gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg
5400 ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga
taccgctcgc 5460 cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg
aagcggaaga gcgcccaata 5520 cgcaaaccgc ctctccccgc gcgttggccg
attcattaat ccagctggca cgacaggttt 5580 cccgactgga aagcgggcag
tgagcgcaac gcaattaatg tgagttacct cactcattag 5640 gcaccccagg
ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga 5700
taacaatttc acacaggaaa cagctatgac catgattacg aattaa 5746 <210>
SEQ ID NO 45 <211> LENGTH: 286 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 45 Met Ser
Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 1 5 10 15
Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 20
25 30 Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu
Asp 35 40 45 Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu
Glu Arg Phe 50 55 60 Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys
Gly Ala Val Leu Ser 65 70 75 80 Arg Asp Asp Ala Gly Gln Glu Gln Leu
Gly Arg Arg Ile His Tyr Ser 85 90 95 Gln Asn Asp Leu Val Glu Tyr
Ser Pro Val Thr Glu Lys His Leu Thr 100 105 110 Asp Gly Met Thr Val
Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 115 120 125 Asp Asn Thr
Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 130 135 140 Glu
Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 145 150
155 160 Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu
Arg 165 170 175 Asp Thr Thr Met Pro Ala Ala Met Ala Thr Thr Leu Arg
Lys Leu Leu 180 185 190 Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln
Gln Leu Ile Asp Trp 195 200 205 Met Glu Ala Asp Lys Val Ala Gly Pro
Leu Leu Arg Ser Ala Leu Pro 210 215 220 Ala Gly Trp Phe Ile Ala Asp
Lys Ser Gly Ala Gly Glu Arg Gly Ser 225 230 235 240 Arg Gly Ile Ile
Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 245 250 255 Val Val
Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 260 265 270
Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 275 280 285
<210> SEQ ID NO 46 <211> LENGTH: 5074 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46
ttcgagctcg cccgacattg attattgact agttattaat agtaatcaat tacggggtca
60 ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa
tggcccgcct 120 ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa
tgacgtatgt tcccatagta 180 acgccaatag ggactttcca ttgacgtcaa
tgggtggagt atttacggta aactgcccac 240 ttggcagtac atcaagtgta
tcatatgcca agtacgcccc ctattgacgt caatgacggt 300 aaatggcccg
cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag 360
tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat
420 gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat
tgacgtcaat 480 gggagtttgt tttggcacca aaatcaacgg gactttccaa
aatgtcgtaa caactccgcc 540 ccattgacgc aaatgggcgg taggcgtgta
cggtgggagg tctatataag cagagctcgt 600 ttagtgaacc gtcagatcgc
ctggagacgc catccacgct gttttgacct ccatagaaga 660 caccgggacc
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt 720
gccaagagtg acgtaagtac cgcctataga gtctataggc ccaccccctt ggcttcgtta
780 gaacgcggct acaattaata cataacctta tgtatcatac acatacgatt
taggtgacac 840 tatagaataa catccacttt gcctttctct ccacaggtgt
ccactcccag gtccaactgc 900 acctcggttc tatcgattga attccaccat
gggatggtca tgtatcatcc tttttctagt 960 agcaactgca accggtgtac
actcgagcgt acggtggctg caccatctgt cttcatcttc 1020 ccgccatctg
atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 1080
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac
1140 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct
cagcagcacc 1200 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct
acgcctgcga agtcacccat 1260 cagggcctga gctcgcccgt cacaaagagc
ttcaacaggg gagagtgtta gaagcttggc 1320 cgccatggcc caacttgttt
attgcagctt ataatggtta caaataaagc aatagcatca 1380
caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca
1440 tcaatgtatc ttatcatgtc tggatcgatc gggaattaat tcggcgcagc
accatggcct 1500 gaaataacct ctgaaagagg aacttggtta ggtaccttct
gaggcggaaa gaaccagctg 1560 tggaatgtgt gtcagttagg gtgtggaaag
tccccaggct ccccagcagg cagaagtatg 1620 caaagcatgc atctcaatta
gtcagcaacc aggtgtggaa agtccccagg ctccccagca 1680 ggcagaagta
tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact 1740
ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta
1800 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt
ccagaagtag 1860 tgaggaggct tttttggagg cctaggcttt tgcaaaaagc
tgttaacagc ttggcactgg 1920 ccgtcgtttt acaacgtcgt gactgggaaa
accctggcgt tacccaactt aatcgccttg 1980 cagcacatcc ccccttcgcc
agctggcgta atagcgaaga ggcccgcacc gatcgccctt 2040 cccaacagtt
gcgtagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 2100
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg
2160 cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac
ttgccagcgc 2220 cctagcgccc gctcctttcg ctttcttccc ttcctttctc
gccacgttcg ccggctttcc 2280 ccgtcaagct ctaaatcggg ggctcccttt
agggttccga tttagtgctt tacggcacct 2340 cgaccccaaa aaacttgatt
tgggtgatgg ttcacgtagt gggccatcgc cctgatagac 2400 ggtttttcgc
cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac 2460
tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat
2520 ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga
attttaacaa 2580 aatattaacg tttacaattt tatggtgcac tctcagtaca
atctgctctg atgccgcata 2640 gttaagccaa ctccgctatc gctacgtgac
tgggtcatgg ctgcgccccg acacccgcca 2700 acacccgctg acgcgccctg
acgggcttgt ctgctcccgg catccgctta cagacaagct 2760 gtgaccgtct
ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg 2820
aggcagtatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc
2880 atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt
gcgcggaacc 2940 cctatttgtt tatttttcta aatacattca aatatgtatc
cgctcatgag acaataaccc 3000 tgataaatgc ttcaataata ttgaaaaagg
aagagtatga gtattcaaca tttccgtgtc 3060 gcccttattc ccttttttgc
ggcattttgc cttcctgttt ttgctcaccc agaaacgctg 3120 gtgaaagtaa
aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat 3180
ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc
3240 acttttaaag ttctgctatg tggcgcggta ttatcccgtg atgacgccgg
gcaagagcaa 3300 ctcggtcgcc gcatacacta ttctcagaat gacttggttg
agtactcacc agtcacagaa 3360 aagcatctta cggatggcat gacagtaaga
gaattatgca gtgctgccat aaccatgagt 3420 gataacactg cggccaactt
acttctgaca acgatcggag gaccgaagga gctaaccgct 3480 tttttgcaca
acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat 3540
gaagccatac caaacgacga gcgtgacacc acgatgccag cagcaatggc aacaacgttg
3600 cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt
aatagactgg 3660 atggaggcgg ataaagttgc aggaccactt ctgcgctcgg
cccttccggc tggctggttt 3720 attgctgata aatctggagc cggtgagcgt
gggtctcgcg gtatcattgc agcactgggg 3780 ccagatggta agccctcccg
tatcgtagtt atctacacga cggggagtca ggcaactatg 3840 gatgaacgaa
atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg 3900
tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa
3960 aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta
acgtgagttt 4020 tcgttccact gagcgtcaga ccccgtagaa aagatcaaag
gatcttcttg agatcctttt 4080 tttctgcgcg taatctgctg cttgcaaaca
aaaaaaccac cgctaccagc ggtggtttgt 4140 ttgccggatc aagagctacc
aactcttttt ccgaaggtaa ctggcttcag cagagcgcag 4200 ataccaaata
ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta 4260
gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat
4320 aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc
gcagcggtcg 4380 ggctgaacgg ggggttcgtg cacacagccc agcttggagc
gaacgaccta caccgaactg 4440 agatacctac agcgtgagca ttgagaaagc
gccacgcttc ccgaagggag aaaggcggac 4500 aggtatccgg taagcggcag
ggtcggaaca ggagagcgca cgagggagct tccaggggga 4560 aacgcctggt
atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt 4620
ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta
4680 cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt
atcccctgat 4740 tctgtggata accgtattac cgcctttgag tgagctgata
ccgctcgccg cagccgaacg 4800 accgagcgca gcgagtcagt gagcgaggaa
gcggaagagc gcccaatacg caaaccgcct 4860 ctccccgcgc gttggccgat
tcattaatcc agctggcacg acaggtttcc cgactggaaa 4920 gcgggcagtg
agcgcaacgc aattaatgtg agttacctca ctcattaggc accccaggct 4980
ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac
5040 acaggaaaca gctatgacca tgattacgaa ttaa 5074
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