U.S. patent application number 13/285047 was filed with the patent office on 2012-11-01 for pharmaceutical combinations for the treatment of metabolic disorders.
This patent application is currently assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH. Invention is credited to Bradford S. Hamilton, Thomas Rauch, Manami Tsutsumi.
Application Number | 20120277149 13/285047 |
Document ID | / |
Family ID | 44903228 |
Filed Date | 2012-11-01 |
United States Patent
Application |
20120277149 |
Kind Code |
A1 |
Hamilton; Bradford S. ; et
al. |
November 1, 2012 |
PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC
DISORDERS
Abstract
The invention relates to a pharmaceutical composition comprising
1.a and/or 1.b according to claim 1 in combination with at least
one second therapeutic agent 2 which is suitable in the treatment
or prevention of one or more conditions selected from type 1
diabetes mellitus, type 2 diabetes mellitus, impaired glucose
tolerance and hyperglycemia. In addition the present invention
relates to methods for preventing or treating of metabolic
disorders and related conditions.
Inventors: |
Hamilton; Bradford S.;
(Biberach an der Riss, DE) ; Rauch; Thomas;
(Ehingen-Risstissen, DE) ; Tsutsumi; Manami;
(Stratford, CT) |
Assignee: |
BOEHRINGER INGELHEIM INTERNATIONAL
GMBH
Ingelheim am Rhein
DE
|
Family ID: |
44903228 |
Appl. No.: |
13/285047 |
Filed: |
October 31, 2011 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
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61409241 |
Nov 2, 2010 |
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|
Current U.S.
Class: |
514/6.2 ;
514/11.7; 514/228.8; 514/6.3; 514/6.5; 514/61; 514/7.2 |
Current CPC
Class: |
A61K 31/422 20130101;
A61P 43/00 20180101; A61P 3/00 20180101; A61P 3/06 20180101; A61P
9/00 20180101; A61P 27/06 20180101; A61K 31/155 20130101; A61P
13/12 20180101; A61P 3/08 20180101; A61P 27/02 20180101; A61P 25/00
20180101; A61P 7/00 20180101; A61K 31/5355 20130101; A61K 31/427
20130101; A61K 31/522 20130101; A61K 31/7048 20130101; A61P 3/10
20180101; A61P 3/04 20180101; A61P 9/10 20180101; A61K 45/06
20130101; A61K 31/7048 20130101; A61K 2300/00 20130101; A61K 31/522
20130101; A61K 2300/00 20130101; A61K 31/427 20130101; A61K 2300/00
20130101; A61K 31/422 20130101; A61K 2300/00 20130101; A61K 31/155
20130101; A61K 2300/00 20130101; A61K 31/5355 20130101; A61K
2300/00 20130101 |
Class at
Publication: |
514/6.2 ;
514/228.8; 514/6.5; 514/11.7; 514/6.3; 514/61; 514/7.2 |
International
Class: |
A61K 31/5355 20060101
A61K031/5355; A61K 38/26 20060101 A61K038/26; A61K 31/702 20060101
A61K031/702; A61P 9/00 20060101 A61P009/00; A61P 3/08 20060101
A61P003/08; A61P 3/04 20060101 A61P003/04; A61P 9/10 20060101
A61P009/10; A61P 3/06 20060101 A61P003/06; A61K 38/28 20060101
A61K038/28; A61P 3/10 20060101 A61P003/10 |
Claims
1. A pharmaceutical composition comprising a compound having the
following structure ##STR00002## and/or a compound having the
following structure ##STR00003## or a pharmaceutically acceptable
salt thereof in combination with at least one second therapeutic
agent 2 which is suitable in the treatment or prevention of one or
more conditions selected from type 1 diabetes mellitus, type 2
diabetes mellitus, impaired glucose tolerance (IGT), impaired
fasting blood glucose (IFG), atherosclerose, glaucoma and
hyperglycemia.
2. The pharmaceutical composition according to claim 1
characterized in that the at least one second therapeutic agent 2
is selected from the groups consisting of 2.a) biguanides, 2.b)
sulfonylureas, 2.c) metiglinides, 2.d) thiazolidindiones, 2.e)
alpha-glucosidase inhibitors, 2.f) insulins and insulin analogues,
2.g) dipeptidyl peptidase IV inhibitors (DPP IV inhibitors) 2.h)
SGLT 2 inhibitors, 2.i) PPAR gamma/alpha modulators, 2.j)
glucose-dependent insulinotropic polypeptide agonists, 2.k) beta-3
agonists, 2.l) GLP1 and GLP1 analogues, 2.m) PPAR gamma modulators,
and 2.n) HMG-CoA reductase inhibitors 2.o) PPAR delta
modulators.
3. The pharmaceutical composition according to claim 1
characterized in that the at least one second therapeutic agent 2
is selected from the groups consisting of 2.a), 2.g) and 2.h).
4. The pharmaceutical composition according to claim 2
characterized in that the at least one second therapeutic agent 2
is selected from the group consisting of metformin (2.a1),
phenformin (2.a2), buformin (2.a3), chlorpropamide (2.b1),
acetohexamide (2.b2), tolazamide (2.b3), glibenclamide (2.b4),
tolbutamide (2.b5), glimepiride (2.b6), glipizide (2.b7),
gliquidone (2.b8), glibornurid (2.b9), glyburide (2.b10),
gliclazide (2.b11), nateglinide (2.c1), repaglinide (2.c2),
mitiglinide (2.c3), pioglitazone (2.d1), rosiglitazone (2.d2),
troglitazone (2.d3), ciglitazone (2.d4), miglitol (2.e1), acarbose
(2.e2), voglibose (2.e3), insulin lispro (Humalog.RTM.) (2.f1),
insulin aspartat (Novorapid.RTM.) (2.f2), insulin glulisine
(Apidra.RTM.) (2.f3), regular insulin (2.f4), intermediate acting
insulins like NPH-insulins and long acting insulins like lente
(2.f5) and ultralente insulin (2.f6), insulin glargine
(Lantus.RTM.) (2.f7), insulin detemir (Levemir.RTM.) (2.f8),
denagliptin (2.g1), carmegliptin (2.g2), melogliptin (2.g3)
sitagliptin (2.g4), vildagliptin (2.g5), saxagliptin (2.g6),
linagliptin (2.g7), dutogliptin (2.g8), gemigliptin (2.g9),
alogliptin (2.g10),
6-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-2-methoxy-benzonitrile
(2.h1),
2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-methoxy-benzon-
itrile (2.h2),
1-cyano-2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-methyl-benzene
(2.h3),
2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-hydroxy-benzon-
itrile (2.h4),
2-(4-ethyl-benzyl)-4-(.beta.-D-glucopyranos-1-yl)-benzonitrile
(2.h5),
2-(4-cyclopropyl-benzyl)-4-(.beta.-D-glucopyranos-1-yl)-benzonitrile
(2.h6),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benz-
ene (2.h7),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-244-((R)-tetrahydrofuran-3-yloxy)-
-benzyl]-benzene (2.h8),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-244-((S)-tetrahydrofuran-3-yloxy)-
-benzyl]-benzene (2.h9),
1-methyl-244-((R)-tetrahydrofuran-3-yloxy)-benzyl]-4-(.beta.-D-glucopyran-
os-1-yl)-benzene (2.h10),
1-methyl-244-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(.beta.-D-glucopyran-
os-1-yl)-benzene (2.h11), dapagliflozin (2.h12), atigliflozin (2.
h1 3), remogliflozin (2.h14), sergliflozin (2.h15), canagliflozin
(2.h16), tesaglitazar (2.i1), muraglitazar (2.i2), KRP297 (2.i3),
pramlintide (2.j1), amlyin (2.j2), ritobegron (2.k1), YM 178
(2.k2), solabegron (2.k3), talibegronb (2.k4), N-5984 (2.k5),
GRC-1087 (2.k6), rafabegron (2.k7), FMP825 (2.k8), exenatide
(2.l1), liraglutide (2.l2), taspoglutide (2.l3), metaglidasen,
(2.m1) simvastatin (2.n1), lovastatin (2.n2), provastatin (2.n3),
GW 501516 (2.o1), GW 0742 (2.o2), L165041 (2.o3), LY 465608 (2.o4),
and L-796449 (2.o5).
5. The pharmaceutical composition according to claim 1
characterized in that the at least one second therapeutic agent 2
is (2.a1), (2.d1), (2.g7) and (2.h9).
6. The pharmaceutical composition according to claim 1
characterized in that the composition is suitable for combined or
simultaneous or sequential use of 1.a and/or 1.b and the at least
one second therapeutic agent 2.
7. The pharmaceutical composition according to claim 1
characterized in that 1.a and/or 1.b and the at least one second
therapeutic agent 2 are present in a single dosage form.
8. The pharmaceutical composition according to claim 1
characterized in that 1.a and/or 1.b and the at least one second
therapeutic agent 2 are present each in a separate dosage form.
9. A method of using a compound having the following structure:
##STR00004## and/or a compound having the following structure
##STR00005## or a pharmaceutically acceptable salt thereof, for
preventing, slowing the progression of, delaying or treating a
metabolic disorder selected from the group consisting of type 1
diabetes mellitus, type 2 diabetes mellitus, impaired glucose
tolerance, impaired fasting blood glucose, hyperglycemia,
postprandial hyperglycemia, overweight, obesity and metabolic
syndrome, or improving glycemic control and/or for reducing of
fasting plasma glucose, of postprandial plasma glucose and/or of
glycosylated hemoglobin HbA1c, or preventing, slowing, delaying or
reversing progression from impaired glucose tolerance, impaired
fasting blood glucose, insulin resistance and/or from metabolic
syndrome to type 2 diabetes mellitus, or preventing, slowing the
progression of, delaying or treating of a condition or disorder
selected from the group consisting of complications of diabetes
mellitus such as cataracts and micro- and macrovascular diseases,
such as nephropathy, retinopathy, neuropathy, tissue ischaemia,
arteriosclerosis, myocardial infarction, stroke and peripheral
arterial occlusive disease, or reducing the weight or preventing an
increase of the weight or facilitating a reduction of the weight,
or preventing, slowing, delaying or treating the degeneration of
pancreatic beta cells and/or the decline of the functionality of
pancreatic beta cells and/or for improving and/or restoring the
functionality of pancreatic beta cells and/or restoring the
functionality of pancreatic insulin secretion, or preventing,
slowing, delaying or treating diseases or conditions attributed to
an abnormal accumulation of liver fat, or maintaining and/or
improving the insulin sensitivity and/or for treating or preventing
hyperinsulinemia and/or insulin resistance, or preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis, or preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma, or preventing, slowing progression of delaying or
treating dyslipidemia/hyperlipidemia and complications of
dyslipidemia/hyperlipidemia; improving glycemic control in patients
with type 2 diabetes as an adjunct to diet and exercise, or
improving glycemic control in patients with type 2 diabetes. in a
patient in need thereof characterized in that 1.a and/or 1.b is
administered in combination or alternation with at least one second
therapeutic agent with at least one second therapeutic agent 2
which is suitable in the treatment or prevention of one or more
conditions selected from type 1 diabetes mellitus, type 2 diabetes
mellitus, impaired glucose tolerance (IGT), impaired fasting blood
glucose (IFG), atherosclerose, glaucoma and hyperglycemia.
10. A second therapeutic agent 2 according to claim 1, or a
pharmaceutically acceptable salt thereof, for preventing, slowing
the progression of, delaying or treating a metabolic disorder
selected from the group consisting of type 1 diabetes mellitus,
type 2 diabetes mellitus, impaired glucose tolerance, impaired
fasting blood glucose, hyperglycemia, postprandial hyperglycemia,
overweight, obesity and metabolic syndrome, or improving glycemic
control and/or for reducing of fasting plasma glucose, of
postprandial plasma glucose and/or of glycosylated hemoglobin
HbA1c, or preventing, slowing, delaying or reversing progression
from impaired glucose tolerance, impaired fasting blood glucose,
insulin resistance and/or from metabolic syndrome to type 2
diabetes mellitus, or preventing, slowing the progression of,
delaying or treating of a condition or disorder selected from the
group consisting of complications of diabetes mellitus such as
cataracts and micro- and macrovascular diseases, such as
nephropathy, retinopathy, neuropathy, tissue ischaemia,
arteriosclerosis, myocardial infarction, stroke and peripheral
arterial occlusive disease, or reducing the weight or preventing an
increase of the weight or facilitating a reduction of the weight,
or preventing, slowing, delaying or treating the degeneration of
pancreatic beta cells and/or the decline of the functionality of
pancreatic beta cells and/or for improving and/or restoring the
functionality of pancreatic beta cells and/or restoring the
functionality of pancreatic insulin secretion, or preventing,
slowing, delaying or treating diseases or conditions attributed to
an abnormal accumulation of liver fat, or maintaining and/or
improving the insulin sensitivity and/or for treating or preventing
hyperinsulinemia and/or insulin resistance, or preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis, or preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma, or preventing, slowing progression of delaying or
treating dyslipidemia/hyperlipidemia and complications of
dyslipidemia/hyperlipidemia; improving glycemic control in patients
with type 2 diabetes as an adjunct to diet and exercise, or
improving glycemic control in patients with type 2 diabetes. in a
patient in need thereof characterized in that second therapeutic
agent 2 is administered in combination or alternation with 1.a
and/or 1.b or a pharmaceutically acceptable salt thereof.
11. A method of using a compound having the following structure:
##STR00006## and/or a compound having the following structure
##STR00007## or a pharmaceutically acceptable salt thereof, for
preventing, slowing progression of delaying or treating
athersclerosis and complications of atherosclerosis, or preventing,
slowing progression of delaying or treating athersclerosis and
complications of glaucoma, preventing, slowing progression of
delaying or treating dyslipidemia/hyperlipidemia and complications
of dyslipidemia/hyperlipidemia; improving glycemic control in
patients with type 2 diabetes as an adjunct to diet and exercise,
or improving glycemic control in patients with type 2 diabetes. in
a patient in need thereof.
12. A method of using the pharmaceutical composition according to
claim 1 for preventing, slowing the progression of, delaying or
treating a metabolic disorder selected from the group consisting of
type 1 diabetes mellitus, type 2 diabetes mellitus, impaired
glucose tolerance, impaired fasting blood glucose, hyperglycemia,
postprandial hyperglycemia, overweight, obesity and metabolic
syndrome; or improving glycemic control and/or for reducing of
fasting plasma glucose, of postprandial plasma glucose and/or of
glycosylated hemoglobin HbA1c; or preventing, slowing, delaying or
reversing progression from impaired glucose tolerance, insulin
resistance and/or from metabolic syndrome to type 2 diabetes
mellitus; or preventing, slowing the progression of, delaying or
treating of a condition or disorder selected from the group
consisting of complications of diabetes mellitus such as cataracts
and micro- and macrovascular diseases, such as nephropathy,
retinopathy, neuropathy, tissue ischaemia, arteriosclerosis,
myocardial infarction, stroke and peripheral arterial occlusive
disease; or reducing the weight or preventing an increase of the
weight or facilitating a reduction of the weight; or preventing,
slowing, delaying or treating the degeneration of pancreatic beta
cells and/or the decline of the functionality of pancreatic beta
cells and/or for improving and/or restoring the functionality of
pancreatic beta cells and/or restoring the functionality of
pancreatic insulin secretion; or for preventing, slowing, delaying
or treating diseases or conditions attributed to an abnormal
accumulation of liver fat; or maintaining and/or improving the
insulin sensitivity and/or for treating or preventing
hyperinsulinemia and/or insulin resistance; or preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis, or preventing, slowing
progression of delaying or treating athersclerosis and
complications of glaucoma, or preventing, slowing progression of
delaying or treating dyslipidemia/hyperlipidemia and complications
of dyslipidemia/hyperlipidemia; improving glycemic control in
patients with type 2 diabetes as an adjunct to diet and exercise,
or improving glycemic control in patients with type 2 diabetes in a
patient in need thereof.
13. The method according to claim 9 wherein, the patient is an
individual diagnosed of one or more of the conditions selected from
the group consisting of overweight, obesity, visceral obesity and
abdominal obesity.
14. The method according to claim 9, wherein the patient is an
individual who shows one, two or more of the following conditions:
(a) a fasting blood glucose or serum glucose concentration greater
than 110 mg/dL, in particular greater than 125 mg/dL; (b) a
postprandial plasma glucose equal to or greater than 140 mg/dL; (c)
an HbA1c value equal to or greater than 6.5%, in particular equal
to or greater than 8.0%.
15. The method according to claim 9, wherein the patient is an
individual wherein one, two, three or more of the following
conditions are present: (a) obesity, visceral obesity and/or
abdominal obesity, (b) triglyceride blood level .gtoreq.150 mg/dL,
(c) HDL-cholesterol blood level <40 mg/dL in female patients and
<50 mg/dL in male patients, (d) a systolic blood pressure
.gtoreq.130 mm Hg and a diastolic blood pressure 85 mm Hg, (e) a
fasting blood glucose level .gtoreq.110 mg/dL, (f) LDL-cholesterol
blood levels .gtoreq.130 mg/dL.
16. The method according to claim 9, wherein the patient is an
individual for whom the monotherapy with metformin is
contraindicated and/or who has an intolerance against metformin at
therapeutic doses.
17. The method according to claim 9, wherein the patient is an
individual with insufficient glycemic control despite treatment
with one or more antidiabetic drugs selected from the groups 2a) to
2n) 2.a) biguanides, 2.b) sulfonylureas, 2.c) metiglinides, 2.d)
thiazolidindiones, 2.e) alpha-glucosidase inhibitors, 2.f) insulins
and insulin analogues, 2.g) dipeptidyl peptidase IV inhibitors (DPP
IV inhibitors) 2.h) SGLT 2 inhibitors, 2.i) PPAR gamma/alpha
modulators, 2.j) glucose-dependent insulinotropic polypeptide
agonists, 2.k) beta-3 agonists, 2.l) GLP1 and GLP1 analogues, 2.m)
PPAR gamma modulators, and 2.n) HMG-CoA reductase inhibitors.
18. The method according to claim 9, wherein the at least one
second therapeutic agent 2 is selected from (2.a1), (2.d1), (2.g7)
and (2.h9).
Description
TECHNICAL FIELD OF THE INVENTION
[0001] The invention is directed to pharmaceutical combinations
comprising an inhibitor of 11-beta-hydroxysteroid dehydrogenase 1
of formula 1.a or 1.b as one active ingredient in combination with
at least one additional active ingredient 2 which is suitable in
the treatment or prevention of one or more conditions selected from
type 1 diabetes mellitus, type 2 diabetes mellitus, impaired
glucose tolerance, impaired fasting blood glucose, hyperglycemia,
dyslipidemia/hyperlipidemia.
[0002] Furthermore the invention relates to methods [0003] for
preventing, slowing progression of, delaying, or treating a
metabolic disorder; [0004] for improving glycemic control and/or
for reducing of fasting plasma glucose, of postprandial plasma
glucose and/or of glycosylated hemoglobin HbA1c; [0005] for
preventing, slowing, delaying or reversing progression from
impaired glucose tolerance, impaired fasting blood glucose, insulin
resistance and/or from metabolic syndrome to type 2 diabetes
mellitus; [0006] for preventing, slowing progression of, delaying
or treating of a condition or disorder selected from the group
consisting of complications of diabetes mellitus; [0007] for
reducing the weight or preventing an increase of the weight or
facilitating a reduction of the weight; [0008] for preventing or
treating the degeneration of pancreatic beta cells and/or for
improving and/or restoring the functionality of pancreatic beta
cells and/or restoring the functionality of pancreatic insulin
secretion; [0009] for preventing, slowing, delaying or treating
diseases or conditions attributed to an abnormal accumulation of
liver fat; [0010] maintaining and/or improving the insulin
sensitivity and/or for treating or preventing hyperinsulinemia
and/or insulin resistance; or [0011] preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis; [0012] preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma; [0013] preventing, slowing progression of delaying or
treating dyslipidemia/hyperlipidemia and complications of
dyslipidemia/hyperlipidemia; [0014] improving glycemic control in
patients with type 2 diabetes as an adjunct to diet and exercise;
or [0015] improving glycemic control in patients with type 2
diabetes
[0016] in patients in need thereof characterized in that an
inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 of formula 1.a
or 1.b as defined hereinafter is administered in combination or
alternation with at least one second therapeutic agent 2 as defined
hereinafter.
[0017] Furthermore the invention relates to methods [0018]
preventing, slowing progression of delaying or treating
athersclerosis and complications of atherosclerosis; or [0019]
preventing, slowing progression of delaying or treating glaucoma
and complications of glaucoma; or [0020] preventing, slowing
progression of delaying or treating dyslipidemia/hyperlipidemia and
complications of dyslipidemia/hyperlipidemia
[0021] in patients in need thereof characterized in that an
inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 of formula 1.a
or 1.b as defined hereinafter is administered to a patient in need
thereof.
[0022] In addition the present invention relates to the use of an
inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 of formula 1.a
or 1.b as defined hereinafter for the manufacture of a medicament
for use in a method as described hereinbefore and hereinafter.
[0023] In addition the present invention relates to the use of at
least one second therapeutic agent 2 as defined hereinafter for the
manufacture of a medicament for use in a method as described
hereinbefore and hereinafter.
[0024] The invention also relates to a use of a pharmaceutical
composition according to this invention for use in a method as
described hereinbefore and hereinafter.
BACKGROUND OF THE INVENTION
[0025] The compounds
(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydrop-
yridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one (compound
1.a) and
3-{(S)-1-[4-(1-Cyclopropyl-2-oxo-1,2-dihydro-pyridin-4-yl)-phenyl]-ethyl}-
-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
(compound 1.b), solvates, hydrates and pharmaceutically acceptable
salts have been disclosed in WO 09/134400 and WO 10/011314 and have
the following structure:
##STR00001##
[0026] Compounds 1.a and 1.b are effective inhibitors of
11-beta-hydroxysteroid dehydrogenase 1 and are therefore promising
therapeutic agents for ameliorating or treating disorders or
diseases in which decreasing the level of cortisol is effective in
treating a disease state.
[0027] Type 2 diabetes is an increasingly prevalent disease that
due to a high frequency of complications leads to a significant
reduction of life expectancy. Because of diabetes-associated
microvascular complications, type 2 diabetes is currently the most
frequent cause of adult-onset loss of vision, renal failure, and
amputations in the industrialized world. In addition, the presence
of type 2 diabetes is associated with a two to five fold increase
in cardiovascular disease risk.
[0028] After long duration of disease, most patients with type 2
diabetes will eventually fail on oral therapy and become insulin
dependent with the necessity for daily injections and multiple
daily glucose measurements.
[0029] The UKPDS (United Kingdom Prospective Diabetes Study)
demonstrated that intensive treatment with metformin, sulfonylureas
or insulin resulted in only a limited improvement of glycemic
control (difference in HbA1c .about.0.9%). In addition, even in
patients within the intensive treatment arm glycemic control
deteriorated significantly over time and this was attributed to
deterioration of .beta.-cell function. Importantly, intensive
treatment was not associated with a significant reduction in
macrovascular complications, i.e. cardiovascular events.
[0030] Therefore there is an unmet medical need for methods,
medicaments and pharmaceutical compositions with a good efficacy
with regard to glycemic control, with regard to disease-modifying
properties and with regard to reduction of cardiovascular morbidity
and mortality while at the same time showing an improved safety
profile.
AIM OF THE PRESENT INVENTION
[0031] The aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing
progression of, delaying or treating a metabolic disorder.
[0032] A further aim of the present invention is to provide a
pharmaceutical composition and method for improving glycemic
control in a patient in need thereof.
[0033] Another aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing or
delaying progression from impaired glucose tolerance (IGT),
impaired fasting blood glucose (IFG), insulin resistance and/or
metabolic syndrome to type 2 diabetes mellitus.
[0034] Yet another aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing
progression of, delaying or treating of a condition or disorder
from the group consisting of complications of diabetes
mellitus.
[0035] A further aim of the present invention is to provide a
pharmaceutical composition and method for reducing the weight or
preventing an increase of the weight in a patient in need
thereof.
[0036] Another aim of the present invention is to provide a new
pharmaceutical composition with a high efficacy for the treatment
of metabolic disorders, in particular of diabetes mellitus,
impaired glucose tolerance (IGT), impaired fasting blood glucose
(IFG), and/or hyperglycemia, which has good to very good
pharmacological and/or pharmacokinetic and/or physicochemical
properties.
[0037] A further aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis.
[0038] A further aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma.
[0039] A further aim of the present invention is to provide a
pharmaceutical composition and method for preventing, slowing
progression of delaying or treating dyslipidemia/hyperlipidemia and
complications of dyslipidemia/hyperlipidemia.
[0040] Further aims of the present invention become apparent to the
one skilled in the art by description hereinbefore and in the
following and by the examples.
SUMMARY OF THE INVENTION
[0041] Within the scope of the present invention it has now
surprisingly been found that a pharmaceutical composition
comprising compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof can advantageously be
used in combination with at least one second therapeutic agent 2
which is suitable in the treatment or prevention of one or more
conditions selected from type 1 diabetes mellitus, type 2 diabetes
mellitus, impaired glucose tolerance (IGT), impaired fasting blood
glucose (IFG) and hyperglycemia for preventing, slowing progression
of, delaying or treating a metabolic disorder, in particular in
improving glycemic control in patients. This opens up new
therapeutic possibilities in the treatment and prevention of type 2
diabetes mellitus, overweight, obesity, complications of diabetes
mellitus and of neighboring disease states.
[0042] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used for preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis.
[0043] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used for preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma.
[0044] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used for preventing, slowing
progression of delaying or treating dyslipidemia/hyperlipidemia and
complications of dyslipidemia/hyperlipidemia.
[0045] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used in combination with at
least one second therapeutic agent 2 for preventing, slowing
progression of delaying or treating athersclerosis and
complications of atherosclerosis.
[0046] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used in combination with at
least one second therapeutic agent 2 for preventing, slowing
progression of delaying or treating glaucoma.
[0047] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used in combination with at
least one second therapeutic agent 2 for preventing, slowing
progression of delaying or treating dyslipidemia/hyperlipidemia and
complications of dyslipidemia/hyperlipidemia.
[0048] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used in combination with at
least one second therapeutic agent 2 as defined below and above,
for improving glycemic control in patients with type 2
diabetes.
[0049] Further also within the scope of the present invention is a
pharmaceutical composition comprising compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof which can advantageously be used in combination with at
least one second therapeutic agent 2 as defined below and above, as
an adjunct to diet and exercise to improve glycemic control in
patients with type 2 diabetes mellitus.
[0050] Therefore in a first aspect the present invention provides a
pharmaceutical composition comprising a compound 1.a and/or a
compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof in combination with at least one second therapeutic
agent 2 which is suitable in the treatment or prevention of one or
more conditions selected from type 1 diabetes mellitus, type 2
diabetes mellitus, impaired glucose tolerance (IGT), impaired
fasting blood glucose (IFG), hyperglycemia,
dyslipidemia/hyperlipidemia.
[0051] According to another aspect of the invention there is
provided a method for preventing, slowing the progression of,
delaying or treating a metabolic disorder selected from the group
consisting of type 1 diabetes mellitus, type 2 diabetes mellitus,
impaired glucose tolerance (IGT), impaired fasting blood glucose
(IFG), hyperglycemia, postprandial hyperglycemia, overweight,
obesity, metabolic syndrome, atherosclerosis, glaucoma,
dyslipidemia/hyperlipidemia in a patient in need thereof
characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered in combination or alternation with at least one
second therapeutic agent 2 as defined hereinbefore and
hereinafter.
[0052] According to another aspect of the invention there is
provided a method for improving glycemic control and/or for
reducing of fasting plasma glucose, of postprandial plasma glucose
and/or of glycosylated hemoglobin HbA1c in a patient in need
thereof characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered in combination or alternation with at least one
second therapeutic agent 2 as defined hereinbefore and
hereinafter.
[0053] According to another aspect of the invention there is
provided a method for improving glycemic control in patients with
type 2 diabetes in a patient in need thereof characterized in that
a compound 1.a and/or a compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof is/are administered in
combination or alternation with at least one second therapeutic
agent 2 as defined hereinbefore and hereinafter.
[0054] According to another aspect of the invention there is
provided a method for improving glycemic control in patients with
type 2 diabetes as an adjunct to diet and exercise in a patient in
need thereof characterized in that a compound 1.a and/or a compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof is/are administered in combination or alternation with at
least one second therapeutic agent 2 as defined hereinbefore and
hereinafter.
[0055] According to another aspect of the invention there is
provided a method for slowing progression of delaying or treating
athersclerosis and complications of atherosclerosis in a patient in
need thereof characterized in that a compound 1.a and/or a compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof is/are administered to a patient in need thereof.
[0056] According to another aspect of the invention there is
provided a method for slowing progression of delaying or treating
glaucoma and complications of glaucoma in a patient in need thereof
characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered to a patient in need thereof.
[0057] According to another aspect of the invention there is
provided a method for slowing progression of delaying or treating
dyslipidemia/hyperlipidemia and complications of
dyslipidemia/hyperlipidemia to a patient in need thereof.
[0058] The pharmaceutical composition according to this invention
may also have valuable disease-modifying properties with respect to
diseases or conditions related to impaired glucose tolerance (IGT),
impaired fasting blood glucose (IFG), insulin resistance,
atherosclerosis, glaucoma, dyslipidemia/hyperlipidemia and/or
metabolic syndrome.
[0059] According to another aspect of the invention there is
provided a method for preventing, slowing, delaying or reversing
progression from impaired glucose tolerance (IGT), impaired fasting
blood glucose (IFG), insulin resistance and/or from metabolic
syndrome to type 2 diabetes mellitus in a patient in need thereof
characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered in combination or alternation with at least one
second therapeutic agent 2 as defined hereinbefore and
hereinafter.
[0060] As by the use of a pharmaceutical composition according to
this invention an improvement of the glycemic control in patients
in need thereof is obtainable, also those conditions and/or
diseases related to or caused by an increased blood glucose level
may be treated.
[0061] According to another aspect of the invention there is
provided a method for preventing, slowing the progression of,
delaying or treating of a condition or disorder selected from the
group consisting of complications of diabetes mellitus such as
glaucoma, cataracts and micro- and macrovascular diseases, such as
nephropathy, retinopathy, neuropathy, tissue ischaemia,
arteriosclerosis, myocardial infarction, stroke and peripheral
arterial occlusive disease, in a patient in need thereof
characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered in combination or alternation with at least one
second therapeutic agent 2 as defined hereinbefore and hereinafter.
The term "tissue ischaemia" particularly comprises diabetic
macroangiopathy, diabetic microangiopathy, impaired wound healing
and diabetic ulcer.
[0062] According to another aspect of the invention there is
provided a method for reducing the weight or preventing an increase
of the weight or facilitating a reduction of the weight in a
patient in need thereof characterized in that a compound 1.a and/or
a compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof is/are administered in combination or alternation
with at least one second therapeutic agent 2 as defined
hereinbefore and hereinafter.
[0063] According to another aspect of the invention there is
provided a method for preventing, slowing, delaying or treating the
degeneration of pancreatic beta cells and/or the decline of the
functionality of pancreatic beta cells and/or for improving and/or
restoring the functionality of pancreatic beta cells and/or
restoring the functionality of pancreatic insulin secretion in a
patient in need thereof characterized in that a compound 1.a and/or
a compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof is/are administered in combination or alternation
with at least one second therapeutic agent 2 as defined
hereinbefore and hereinafter.
[0064] By the administration of a combination or pharmaceutical
composition according to the present invention an abnormal
accumulation of fat in the liver may be reduced or inhibited.
Therefore according to another aspect of the present invention
there is provided a method for preventing, slowing, delaying or
treating diseases or conditions attributed to an abnormal
accumulation of liver fat in a patient in need thereof c
characterized in that a compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
is/are administered in combination or alternation with at least one
second therapeutic agent 2 as defined hereinbefore and hereinafter.
Diseases or conditions which are attributed to an abnormal
accumulation of liver fat are particularly selected from the group
consisting of general fatty liver, non-alcoholic fatty liver
(NAFL), non-alcoholic steatohepatitis (NASH),
hyperalimentation-induced fatty liver, diabetic fatty liver,
alcoholic-induced fatty liver or toxic fatty liver.
[0065] As a result thereof another aspect of the invention provides
a method for maintaining and/or improving the insulin sensitivity
and/or for treating or preventing hyperinsulinemia and/or insulin
resistance in a patient in need thereof characterized in that a
compound 1.a and/or a compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof is/are administered in
combination or alternation with at least one second therapeutic
agent 2 as defined hereinbefore and hereinafter.
[0066] According to another aspect of the invention there is
provided a compound 1.a and/or a compound 1.b, solvates, hydrates
or pharmaceutically acceptable salts thereof for the use in [0067]
preventing, slowing the progression of, delaying or treating a
metabolic disorder selected from the group consisting of type 1
diabetes mellitus, type 2 diabetes mellitus, impaired glucose
tolerance (IGT), impaired fasting blood glucose (IFG),
hyperglycemia, postprandial hyperglycemia, overweight, obesity and
metabolic syndrome; or [0068] improving glycemic control and/or for
reducing of fasting plasma glucose, of postprandial plasma glucose
and/or of glycosylated hemoglobin HbA1c; or [0069] preventing,
slowing, delaying or reversing progression from impaired glucose
tolerance (IGT), impaired fasting blood glucose (IFG), insulin
resistance and/or from metabolic syndrome to type 2 diabetes
mellitus; or [0070] preventing, slowing the progression of,
delaying or treating of a condition or disorder selected from the
group consisting of complications of diabetes mellitus such as
cataracts and micro- and macrovascular diseases, such as
nephropathy, retinopathy, neuropathy, tissue ischaemia,
arteriosclerosis, myocardial infarction, stroke and peripheral
arterial occlusive disease; or [0071] reducing the weight or
preventing an increase of the weight or facilitating a reduction of
the weight; or [0072] preventing, slowing, delaying or treating the
degeneration of pancreatic beta cells and/or the decline of the
functionality of pancreatic beta cells and/or for improving and/or
restoring the functionality of pancreatic beta cells and/or
restoring the functionality of pancreatic insulin secretion; or
[0073] preventing, slowing, delaying or treating diseases or
conditions attributed to an abnormal accumulation of liver fat; or
[0074] maintaining and/or improving the insulin sensitivity and/or
for treating or preventing hyperinsulinemia and/or insulin
resistance; or [0075] preventing, slowing progression of delaying
or treating athersclerosis and complications of atherosclerosis; or
[0076] preventing, slowing progression of delaying or treating
glaucoma and complications of glaucoma; [0077] preventing, slowing
progression of delaying or treating dyslipidemia/hyperlipidemia and
complications of dyslipidemia/hyperlipidemia; or [0078] improving
glycemic control in patients with type 2 diabetes as an adjunct to
diet and exercise; or [0079] improving glycemic control in patients
with type 2 diabetes
[0080] in a patient in need thereof characterized in that the
compound 1.a and/or a compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof is administered in
combination or alternation with at least one second therapeutic
agent 2 as defined hereinbefore and hereinafter.
[0081] According to another aspect of the invention there is
provided least one second therapeutic agent 2 as defined
hereinbefore and hereinafter for the use in [0082] preventing,
slowing the progression of, delaying or treating a metabolic
disorder selected from the group consisting of type 1 diabetes
mellitus, type 2 diabetes mellitus, impaired glucose tolerance
(IGT), impaired fasting blood glucose (IFG), hyperglycemia,
postprandial hyperglycemia, overweight, obesity and metabolic
syndrome; or [0083] improving glycemic control and/or for reducing
of fasting plasma glucose, of postprandial plasma glucose and/or of
glycosylated hemoglobin HbA1c; or [0084] preventing, slowing,
delaying or reversing progression from impaired glucose tolerance
(IGT), impaired fasting blood glucose (IFG), insulin resistance
and/or from metabolic syndrome to type 2 diabetes mellitus; or
[0085] preventing, slowing the progression of, delaying or treating
of a condition or disorder selected from the group consisting of
complications of diabetes mellitus such as cataracts and micro- and
macrovascular diseases, such as nephropathy, retinopathy,
neuropathy, tissue ischaemia, arteriosclerosis, myocardial
infarction, stroke and peripheral arterial occlusive disease; or
[0086] reducing the weight or preventing an increase of the weight
or facilitating a reduction of the weight; or [0087] preventing,
slowing, delaying or treating the degeneration of pancreatic beta
cells and/or the decline of the functionality of pancreatic beta
cells and/or for improving and/or restoring the functionality of
pancreatic beta cells and/or restoring the functionality of
pancreatic insulin secretion; or [0088] preventing, slowing,
delaying or treating diseases or conditions attributed to an
abnormal accumulation of liver fat; or [0089] maintaining and/or
improving the insulin sensitivity and/or for treating or preventing
hyperinsulinemia and/or insulin resistance; or [0090] preventing,
slowing progression of delaying or treating athersclerosis and
complications of atherosclerosis; or [0091] preventing, slowing
progression of delaying or treating glaucoma and complications of
glaucoma; [0092] preventing, slowing progression of delaying or
treating dyslipidemia/hyperlipidemia and complications of
dyslipidemia/hyperlipidemia; [0093] improving glycemic control in
patients with type 2 diabetes as an adjunct to diet and exercise;
or [0094] improving glycemic control in patients with type 2
diabetes
[0095] in a patient in need thereof characterized in that the least
one second therapeutic agent 2 is administered in combination or
alternation with compound 1.a and/or a compound 1.b, solvates,
hydrates or pharmaceutically acceptable salts thereof.
[0096] According to another aspect of the invention there is
provided a pharmaceutical composition according to the present
invention for the use for a therapeutic and preventive method as
described hereinbefore and hereinafter.
DEFINITIONS
[0097] The term "active ingredient" of a pharmaceutical composition
according to the present invention means the compound 1.a and/or
compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof and/or the second therapeutic ingredient 2.
[0098] The term "body mass index" or "BMI" of a human patient is
defined as the weight in kilograms divided by the square of the
height in meters, such that BMI has units of kg/m.sup.2.
[0099] The term "overweight" is defined as the condition wherein
the individual has a BMI greater than or 25 kg/m.sup.2 and less
than 30 kg/m.sup.2. The terms "overweight" and "pre-obese" are used
interchangeably.
[0100] The term "obesity" is defined as the condition wherein the
individual has a BMI equal to or greater than 30 kg/m.sup.2.
According to a WHO definition the term obesity may be categorized
as follows: the term "class I obesity" is the condition wherein the
BMI is equal to or greater than 30 kg/m.sup.2 but lower than 35
kg/m.sup.2; the term "class II obesity" is the condition wherein
the BMI is equal to or greater than 35 kg/m.sup.2 but lower than 40
kg/m.sup.2; the term "class III obesity" is the condition wherein
the BMI is equal to or greater than 40 kg/m.sup.2.
[0101] The term "visceral obesity" is defined as the condition
wherein a waist-to-hip ratio of greater than or equal to 1.0 in men
and 0.8 in women is measured. It defines the risk for insulin
resistance and the development of pre-diabetes.
[0102] The term "abdominal obesity" is usually defined as the
condition wherein the waist circumference is >40 inches or 102
cm in men, and is >35 inches or 94 cm in women. With regard to a
Japanese ethnicity or Japanese patients abdominal obesity may be
defined as waist circumference .gtoreq.85 cm in men and .gtoreq.90
cm in women (see e.g. investigating committee for the diagnosis of
metabolic syndrome in Japan).
[0103] The term "euglycemia" is defined as the condition in which a
subject has a fasting blood glucose concentration within the normal
range, greater than 70 mg/dL (3.89 mmol/L) and less than 110 mg/dL
(6.11 mmol/L). The word "fasting" has the usual meaning as a
medical term.
[0104] The term "hyperglycemia" is defined as the condition in
which a subject has a fasting blood glucose concentration above the
normal range, greater than 110 mg/dL (6.11 mmol/L). The word
"fasting" has the usual meaning as a medical term.
[0105] The term "hypoglycemia" is typically defined as a condition
in which a subject has symptoms known to be caused by
hypoglycaemia, i.e. low blood glucose concentration at the time the
symptoms occur and reversal or improvement of symptoms or problems
when the blood glucose concentration is restored to normal.
Typically, plasma glucose levels below 70 mg/dl (3.9 mmol/L), in
particular below 60 mg/dl (3.3 mmol/L), are considered
hypoglycaemic.
[0106] The term "postprandial hyperglycemia" is defined as the
condition in which a subject has a 2 hour postprandial blood
glucose or serum glucose concentration greater than 200 mg/dL
(11.11 mmol/L).
[0107] The term "impaired fasting blood glucose" or "IFG" is
defined as the condition in which a subject has a fasting blood
glucose concentration or fasting serum glucose concentration
greater than 110 mg/dL and less than 126 mg/dl (7.00 mmol/L).
[0108] The term "impaired glucose tolerance" or "IGT" is defined as
the condition in which a subject has a 2 hour postprandial blood
glucose or serum glucose concentration greater than 140 mg/dl (7.78
mmol/L) and less than 200 mg/dL (11.11 mmol/L). The abnormal
glucose tolerance, i.e. the 2 hour postprandial blood glucose or
serum glucose concentration can be measured as the blood sugar
level in mg of glucose per dL of plasma 2 hours after taking 75 g
of glucose after a fast.
[0109] The term "hyperinsulinemia" is defined as the condition in
which a subject with insulin resistance, with or without
euglycemia, in which the fasting or postprandial serum or plasma
insulin concentration is elevated above that of normal, lean
individuals without insulin resistance, having a waist-to-hip
ration <1.0 (for men) or <0.8 (for women).
[0110] The terms "insulin-sensitizing", "insulin
resistance-improving" or "insulin resistance-lowering" are
synonymous and used interchangeably.
[0111] The term "insulin resistance" is defined as a state in which
circulating insulin levels in excess of the normal response to a
glucose load are required to maintain the euglycemic state (Ford E
S, et al. JAMA. (2002) 287:356-9). A method of determining insulin
resistance is the euglycaemic-hyperinsulinaemic clamp test. The
ratio of insulin to glucose is determined within the scope of a
combined insulin-glucose infusion technique. There is found to be
insulin resistance if the glucose absorption is below the 25th
percentile of the background population investigated (WHO
definition). Rather less laborious than the clamp test are so
called minimal models in which, during an intravenous glucose
tolerance test, the insulin and glucose concentrations in the blood
are measured at fixed time intervals and from these the insulin
resistance is calculated. In this method it is not possible to
distinguish between hepatic and peripheral insulin resistance.
[0112] Furthermore insulin resistance, the response of a patient
with insulin resistance to therapy, insulin sensitivity and
hyperinsulinemia may be quantified by assessing the "homeostasis
model assessment to insulin resistance (HOMA-IR)" score, a reliable
indicator of insulin resistance (Katsuki A, et al. Diabetes Care
2001; 24: 362-5). Further reference is made to methods for the
determination of the HOMA-index for insulin sensitivity (Matthews
et al., Diabetologia 1985, 28: 412-19), of the ratio of intact
proinsulin to insulin (Forst et al., Diabetes 2003, 52(Suppl. 1):
A459) and to an euglycemic clamp study. In addition, plasma
adiponectin levels can be monitored as a potential surrogate of
insulin sensitivity. The estimate of insulin resistance by the
homeostasis assessment model (HOMA)-IR score is calculated with the
formula (Galvin P, et al. Diabet Med 1992;9:921-8):
HOMA-IR=[fasting serum insulin (.mu.U/mL)].times.[fasting plasma
glucose(mmol/L)/22.5]
[0113] As a rule, other parameters are used in everyday clinical
practice to assess insulin resistance. Preferably, the patient's
triglyceride concentration is used, for example, as increased
triglyceride levels correlate significantly with the presence of
insulin resistance.
[0114] Patients with a predisposition for the development of IGT or
IFG or type 2 diabetes are those having euglycemia with
hyperinsulinemia and are by definition, insulin resistant. A
typical patient with insulin resistance is usually overweight or
obese. If insulin resistance can be detected this is a particularly
strong indication of the presence of prediabetes. Thus, it may be
that in order to maintain glucose homoeostasis a person needs 2-3
times as much insulin as another person, without this having any
direct pathological significance.
[0115] The methods to investigate the function of pancreatic
beta-cells are similar to the above methods with regard to insulin
sensitivity, hyperinsulinemia or insulin resistance: An improvement
of the beta-cell function can be measured for example by
determining a HOMA-index for beta-cell function (Matthews et al.,
Diabetologia 1985, 28: 412-19), the ratio of intact proinsulin to
insulin (Forst et al., Diabetes 2003, 52(Suppl. 1): A459), the
insulin/C-peptide secretion after an oral glucose tolerance test or
a meal tolerance test, or by employing a hyperglycemic clamp study
and/or minimal modeling after a frequently sampled intravenous
glucose tolerance test (Stumvoll et al., Eur J Clin Invest 2001,
31: 380-81).
[0116] The term "pre-diabetes" is the condition wherein an
individual is pre-disposed to the development of type 2 diabetes.
Pre-diabetes extends the definition of impaired glucose tolerance
to include individuals with a fasting blood glucose within the high
normal range .gtoreq.100 mg/dL (J. B. Meigs, et al. Diabetes 2003;
52:1475-1484) and fasting hyperinsulinemia (elevated plasma insulin
concentration). The scientific and medical basis for identifying
pre-diabetes as a serious health threat is laid out in a Position
Statement entitled "The Prevention or Delay of Type 2 Diabetes"
issued jointly by the American Diabetes Association and the
National Institute of Diabetes and Digestive and Kidney Diseases
(Diabetes Care 2002; 25:742-749).
[0117] Individuals likely to have insulin resistance are those who
have two or more of the following attributes: 1) overweight or
obese, 2) high blood pressure, 3) hyperlipidemia, 4) one or more
1.sup.st degree relative with a diagnosis of IGT or IFG or type 2
diabetes. Insulin resistance can be confirmed in these individuals
by calculating HOMA-IR score. For the purpose of this invention,
insulin resistance is defined as the clinical condition in which an
individual has a HOMA-IR score>4.0 or a HOMA-IR score above the
upper limit of normal as defined for the laboratory performing the
glucose and insulin assays.
[0118] The term "type 2 diabetes" is defined as the condition in
which a subject has a fasting blood glucose or serum glucose
concentration greater than 125 mg/dL (6.94 mmol/L). The measurement
of blood glucose values is a standard procedure in routine medical
analysis. If a glucose tolerance test is carried out, the blood
sugar level of a diabetic will be in excess of 200 mg of glucose
per dL of plasma 2 hours after 75 g of glucose have been taken on
an empty stomach. In a glucose tolerance test 75 g of glucose are
administered orally to the patient being tested after 10-12 hours
of fasting and the blood sugar level is recorded immediately before
taking the glucose and 1 and 2 hours after taking it. In a healthy
subject the blood sugar level before taking the glucose will be
between 60 and 110 mg per dL of plasma, less than 200 mg per dL 1
hour after taking the glucose and less than 140 mg per dL after 2
hours. If after 2 hours the value is between 140 and 200 mg this is
regarded as abnormal glucose tolerance.
[0119] The term "late stage type 2 diabetes mellitus" includes
patients with a secondary drug failure, indication for insulin
therapy and progression to micro- and macrovascular complications
e.g. diabetic nephropathy, coronary heart disease (CHD).
[0120] The term "HbA1c" refers to the product of a non-enzymatic
glycation of the haemoglobin B chain. Its determination is well
known to one skilled in the art. In monitoring the treatment of
diabetes mellitus the HbA1c value is of exceptional importance. As
its production depends essentially on the blood sugar level and the
life of the erythrocytes, the HbA1c in the sense of a "blood sugar
memory" reflects the average blood sugar levels of the preceding
4-6 weeks. Diabetic patients whose HbA1c value is consistently well
adjusted by intensive diabetes treatment (i.e. <6.5% of the
total haemoglobin in the sample), are significantly better
protected against diabetic microangiopathy. For example metformin
on its own achieves an average improvement in the HbA1c value in
the diabetic of the order of 1.0-1.5%. This reduction of the HbA1 C
value is not sufficient in all diabetics to achieve the desired
target range of <6.5% and preferably <6% HbA1c.
[0121] The "metabolic syndrome", also called "syndrome X" (when
used in the context of a metabolic disorder), also called the
"dysmetabolic syndrome" is a syndrome complex with the cardinal
feature being insulin resistance (Laaksonen D E, et al. Am J
Epidemiol 2002;156:1070-7). According to the ATP III/NCEP
guidelines (Executive Summary of the Third Report of the National
Cholesterol Education Program (NCEP) Expert Panel on Detection,
Evaluation, and Treatment of High Blood Cholesterol in Adults
(Adult Treatment Panel III) JAMA: Journal of the American Medical
Association (2001) 285:2486-2497), diagnosis of the metabolic
syndrome is made when three or more of the following risk factors
are present: [0122] 1. Abdominal obesity, defined as waist
circumference >40 inches or 102 cm in men, and >35 inches or
94 cm in women; or with regard to a Japanese ethnicity or Japanese
patients defined as waist circumference 85 cm in men and 90 cm in
women; [0123] 2. Triglycerides: .gtoreq.150 mg/dL [0124] 3.
HDL-cholesterol <40 mg/dL in men [0125] 4. Blood pressure
.gtoreq.130/85 mm Hg (SBP .gtoreq.130 or DBP .gtoreq.85) [0126] 5.
Fasting blood glucose .gtoreq.110 mg/dL
[0127] The NCEP definitions have been validated (Laaksonen D E, et
al. Am J Epidemiol. (2002) 156:1070-7). Triglycerides and HDL
cholesterol in the blood can also be determined by standard methods
in medical analysis and are described for example in Thomas L
(Editor): "Labor and Diagnose", TH-Books Verlagsgesellschaft mbH,
Frankfurt/Main, 2000.
[0128] According to a commonly used definition hypertension is
diagnosed if the systolic blood pressure (SBP) exceeds a value of
140 mm Hg and diastolic blood pressure (DBP) exceeds a value of 90
mm Hg. If a patient is suffering from manifest diabetes it is
currently recommended that the systolic blood pressure be reduced
to a level below 130 mm Hg and the diastolic blood pressure be
lowered to below 80 mm Hg.
[0129] Within the meaning of the present invention glaucoma is a
disease in which the optic nerve is damaged, leading to
progressive, irreversible loss of vision. It is often, but not
always, associated with increased pressure of the fluid in the eye.
The nerve damage involves loss of retinal ganglion cells in a
characteristic pattern. There are many different sub-types of
glaucoma but they can all be considered a type of optic neuropathy.
Raised intraocular pressure is a significant risk factor for
developing glaucoma (above 21 mmHg or 2.8 kPa). One person may
develop nerve damage at a relatively low pressure, while another
person may have high eye pressure for years and yet never develop
damage. Untreated glaucoma leads to permanent damage of the optic
nerve and resultant visual field loss, which can progress to
blindness.
[0130] Within the meaning of the present invention atherosclerosis
(also known as arteriosclerotic vascular disease or ASVD) is a
condition in which an artery wall thickens as the result of a
build-up of fatty materials such as cholesterol. It is a syndrome
affecting arterial blood vessels, a chronic inflammatory response
in the walls of arteries, in large part due to the accumulation of
macrophage white blood cells and promoted by low-density
lipoproteins (plasma proteins that carry cholesterol and
triglycerides) without adequate removal of fats and cholesterol
from the macrophages by functional high density lipoproteins
(HDL),
[0131] With the term "dyslipidemia/hyperlipidemia" a disorder of
lipoprotein metabolism, including lipoprotein overproduction or
deficiency is defined. Dyslipidemias may be manifested by elevation
of the total cholesterol, the low-density lipoprotein (LDL)
cholesterol and the triglyceride concentrations, and a decrease in
the "good" high-density lipoprotein (HDL) cholesterol concentration
in the blood. Dyslipidemia/hyperlipidemia within the meaning of the
present invention is indicated when LDL cholesterol levels for
adults more than 100 mg/dL (2.60 mmol/L), HDL cholesterol levels
are equal to or lower than 40 mg/dL (1.02 mmol/L), and triglyceride
levels are more than 150 mg/dL (1.7 mmol/L).
[0132] The terms "prophylactically treating" and "preventing" are
used interchangeably.
DETAILED DESCRIPTION
[0133] The aspects according to the present invention, in
particular the pharmaceutical compositions, methods and uses, refer
to compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof.
[0134] The aspects according to the present invention, in
particular the pharmaceutical compositions, methods and uses, refer
to an at least one therapeutic agent 2 which is suitable in the
treatment or prevention of one or more conditions selected from
type 1 diabetes mellitus, type 2 diabetes mellitus, impaired
glucose tolerance (IGT), impaired fasting blood glucose (IFG),
atherosclerosis, glaucoma, dyslipidemia/hyperlipidemia and
hyperglycemia.
[0135] Preferably the at least one second therapeutic agent 2 is
selected from the groups 2.a) to 2.m) consisting of:
[0136] 2.a) biguanides,
[0137] 2.b) sulfonylureas,
[0138] 2.c) metiglinides,
[0139] 2.d) thiazolidindiones,
[0140] 2.e) alpha-glucosidase inhibitors,
[0141] 2.f) insulins and insulin analogues,
[0142] 2.g) dipeptidyl peptidase IV inhibitors (DPP IV
inhibitors)
[0143] 2.h) SGLT 2 inhibitors,
[0144] 2.i) PPAR gamma/alpha modulators,
[0145] 2.j) glucose-dependent insulinotropic polypeptide
agonists,
[0146] 2.k) beta-3 agonists,
[0147] 2.l) GLP1 and GLP1 analogues,
[0148] 2.m) PPAR gamma modulators, and
[0149] 2.n) HMG-CoA reductase inhibitors
[0150] 2.o) PPAR delta modulators.
[0151] More preferably the at least one second therapeutic agent 2
is selected from the groups 2.a), 2.g) and 2.h) as described
hereinbefore and hereinafter.
[0152] Examples of biguanides are metformin (2.a1), phenformin
(2.a2) and buformin (2.a3). Compound 1.a and/or a compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof in
combination with a biguanide, for example with metformin, can
improve glycemic control and may act synergistically with the
biguanide, for example to reduce weight that has overall beneficial
effects on the metabolic syndrome which is commonly associated with
type 2 diabetes mellitus.
[0153] Examples of sulfonylureas are chlorpropamide (2.b1),
acetohexamide (2.b2), tolazamide (2.b3), glibenclamide (2.b4),
tolbutamide (2.b5), glimepiride (2.b6), glipizide (2.b7),
gliquidone (2.b8), glibornurid (2.b9), glyburide (2.b10) and
gliclazide (2.b11). As the efficacy of sulfonylureas wears off over
the course of treatment, a combination of compound 1.a and/or
compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof with a sulfonylurea may offer additional benefit to
the patient in terms of better glycemic control. This combination
may also allow a reduction in the dose of sulfonylureas which may
translate into less hypoglycemia which is an undesirable side
effect of sulfonylureas.
[0154] Examples of meglitinides are nateglinide (2.c1), repaglinide
(2.c2) and mitiglinide (2.c3). As the efficacy of meglitinides
wears off over the course of treatment, a combination of compound
1.a and/or compound 1.b, solvates, hydrates or pharmaceutically
acceptable salts thereof with a meglitinide may offer additional
benefit to the patient in terms of better glycemic control. This
combination may also allow a reduction in the dose of meglitinides
which may translate into less hypoglycemia which is an undesirable
side effect of meglitinides.
[0155] Examples of thiazolidindiones are pioglitazone (2.d1),
rosiglitazone (2.d2), troglitazone (2.d3) and ciglitazone (2.d4).
Additional benefits from the combination of compound 1.a and/or
compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof and a thiazolidindione may relate to synergistic
reduction in blood glucose, an improved glycemic control, an
improvement of fluid retention caused by thiazolidindiones and
reducing or nullifying weight gain associated with the use of
thiazolidindiones.
[0156] Examples of alpha-glucosidase inhibitors are miglitol
(2.e1), acarbose (2.e2) and voglibose (2.e3). A combination of
compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof and an alpha-glucosidase
inhibitor will add to their blood glucose lowering effect and may
allow a reduction in the dose of the alpha-glucosidase inhibitor
that are commonly associated with unpleasant gastro-intestinal side
effects, thereby making it more tolerable and improve the patients
compliance with the treatment.
[0157] Examples of insulins and insulin analogues are short acting
insulins like insulin lispro (Humalog.RTM.) (2.f1), insulin
aspartat (Novorapid.RTM.) (2.f2), insulin glulisine (Apidra.RTM.)
(2.f3), regular insulin (2.f4), intermediate acting insulins like
NPH-insulins and long acting insulins like lente (2.f5) and
ultralente insulin (2.f6), insulin glargine (Lantus.RTM.) (2.f7),
insulin detemir (Levemir.RTM.) (2.f8). The term insulins includes
recombinant insulins. The use of insulin is commonly associated
with weight gain as a result of the anabolic effects of insulin as
well as fluid retention. Combining compound 1.a and/or compound
1.b, solvates, hydrates or pharmaceutically acceptable salts
thereof with insulin or an insulin analogue will achieve a better
glycemic control with lower doses of insulin.
[0158] Examples of DPP IV inhibitors are denagliptin (2.g1),
carmegliptin (2.g2), melogliptin (2.g3) sitagliptin (2.g4),
vildagliptin (2.g5), saxagliptin (2.g6), linagliptin (2.g7),
dutogliptin (2.g8), gemigliptin (2.g9) and alogliptin (2.g10).
Combining compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof with a DPP IV inhibitor
is expected to improve glycemic control.
[0159] Examples of SGLT 2 inhibitors are
6-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-2-methoxy-benzonitrile
(2.h1),
2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-methoxy-benzon-
itrile (2.h2),
1-cyano-2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-methyl-benzene
(2.h3),
2-(4-ethylbenzyl)-4-(.beta.-D-glucopyranos-1-yl)-5-hydroxy-benzon-
itrile (2.h4),
2-(4-ethyl-benzyl)-4-(.beta.-D-glucopyranos-1-yl)-benzonitrile
(2.h5),
2-(4-cyclopropyl-benzyl)-4-(.beta.-D-glucopyranos-1-yl)-benzonitrile
(2.h6),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benz-
ene (2.h7),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy-
)-benzyl]-benzene (2.h8),
1-chloro-4-(.beta.-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy-
)-benzyl]-benzene (2.h9),
1-methyl-244-((R)-tetrahydrofuran-3-yloxy)-benzyl]-4-(.beta.-D-glucopyran-
os-1-yl)-benzene (2.h10),
1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(.beta.-D-glucopyra-
nos-1-yl)-benzene (2.h11), dapagliflozin (2.h12), atigliflozin
(2.h13), remogliflozin (2.h14), sergliflozin (2.h15) and
canagliflozin (2.h16). Combining compound 1.a and/or compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
with a SGLT 2 inhibitor is expected to improve glycemic
control.
[0160] Compounds (2.h1) to (2.h11) and methods of their synthesis
are described for example in the following patent applications: WO
2005/092877, WO 2006/117360, WO 2006/117359, WO 2006/120208, WO
2006/064033, WO 2007/031548, WO 2007/093610, WO 2008/020011, WO
2008/055870.
[0161] Examples of PPAR gamma/alpha modulators are tesaglitazar
(2.i1), muraglitazar (2.i2) and KRP297 (2.i3). Combining compound
1.a and/or compound 1.b, solvates, hydrates or pharmaceutically
acceptable salts thereof with a PPAR gamma/alpha modulator is
expected to improve glycemic control.
[0162] Examples of glucose-dependent insulinotropic polypeptide
agonists are pramlintide (2.j1) and amlyin (2.j2). Combinations
with such second therapeutic agents 2 are expected to improve
glycemic control.
[0163] Examples of beta-3 agonists are ritobegron (2.k1), YM 178
(2.k2), solabegron (2.k3), talibegronb (2.k4), N-5984 (2.k5),
GRC-1087 (2.k6), rafabegron (2.k7) and FMP825 (2.k8). Combining
compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof with a beta-3 agonist is
expected to improve glycemic control.
[0164] An example of GLP1 and GLP1 analogues is exenatide (2.l1),
liraglutide (2.l2) and taspoglutide (2.l3). Combining compound 1.a
and/or compound 1.b, solvates, hydrates or pharmaceutically
acceptable salts thereof with a GLP-1 analogue is expected to
improve glycemic control and add to GLP-1 analogue weight reducing
effect.
[0165] An example of PPAR gamma modulators is metaglidasen (2.m1).
Combining a compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof with a PPAR gamma
modulator is expected to improve glycemic control.
[0166] Examples of HMG-CoA reductase inhibitors are simvastatin
(2.n1), lovastatin (2.n2), and provastatin (2.n3). Combining
compound 1.a and/or compound 1.b, solvates, hydrates or
pharmaceutically acceptable salts thereof with a HMG-CoA reductase
inhibitor is expected to improve glycemic control.
[0167] Examples of PPAR delta modulators are GW 501516 (2.o1), GW
0742 (2.o2), L165041(2.o3), LY 465608 (2.o4), and L-796449
(2.o5).
[0168] Even more preferably the at least one second therapeutic
agent 2 is selected from the group consisting of (2.a1), (2.d1),
(2.g7) and (2.h9).
[0169] Most preferably the at least one second therapeutic agent 2
is selected from the group consisting of consisting of (2.a1),
(2.g7), (2.h9).
[0170] In addition, therapeutic agents 2 can also be selected from
GPR119 agonists.
[0171] According to this invention it is to be understood that the
definitions of the above listed second therapeutic agents 2 also
comprise their pharmaceutically acceptable salts as well as
hydrates, solvates and polymorphic forms thereof.
[0172] Therefore the pharmaceutical compositions, methods and uses
according to this invention relate to combinations which are
selected from the Table 1.
TABLE-US-00001 TABLE 1 Second Composition therapeutic No. Compound
1 agent 2 1 1.a 2.a1 2 1.a 2.a2 3 1.a 2.a3 4 1.a 2.b1 5 1.a 2.b2 6
1.a 2.b3 7 1.a 2.b4 8 1.a 2.b5 9 1.a 2.b6 10 1.a 2.b7 11 1.a 2.b8
12 1.a 2.b9 13 1.a 2.b10 14 1.a 2.b11 15 1.a 2.c1 16 1.a 2.c2 17
1.a 2.c3 18 1.a 2.d1 19 1.a 2.d2 20 1.a 2.d3 21 1.a 2.d4 22 1.a
2.e1 23 1.a 2.e2 24 1.a 2.e3 25 1.a 2.f1 26 1.a 2.f2 27 1.a 2.f3 28
1.a 2.f4 29 1.a 2.f5 30 1.a 2.f6 31 1.a 2.f7 32 1.a 2.f8 33 1.a
2.g1 34 1.a 2.g2 35 1.a 2.g3 36 1.a 2.g4 37 1.a 2.g5 38 1.a 2.g6 39
1.a 2.g7 40 1.a 2.g8 41 1.a 2.g9 42 1.a 2.g10 43 1.a 2.h1 44 1.a
2.h2 45 1.a 2.h3 46 1.a 2.h4 47 1.a 2.h5 48 1.a 2.h6 49 1.a 2.h7 50
1.a 2.h8 51 1.a 2.h9 52 1.a 2.h10 53 1.a 2.h11 54 1.a 2.h12 55 1.a
2.h13 56 1.a 2.h14 57 1.a 2.h15 58 1.a 2.h16 59 1.a 2.i1 60 1.a
2.i2 61 1.a 2.i3 62 1.a 2.j1 63 1.a 2.j2 64 1.a 2.k1 65 1.a 2.k2 66
1.a 2.k3 67 1.a 2.k4 68 1.a 2.k5 69 1.a 2.k6 70 1.a 2.k7 71 1.a
2.k8 72 1.a 2.l1 73 1.a 2.l2 74 1.a 2.l3 75 1.a 2.m1 76 1.a 2.n1 77
1.a 2.n2 78 1.a 2.n3 79 1.a 2.o1 80 1.a 2.o2 81 1.a 2.o3 82 1.a
2.o4 83 1.a 2.o5 84 1.b 2.a1 85 1.b 2.a2 86 1.b 2.a3 87 1.b 2.b1 88
1.b 2.b2 89 1.b 2.b3 90 1.b 2.b4 91 1.b 2.b5 92 1.b 2.b6 93 1.b
2.b7 94 1.b 2.b8 95 1.b 2.b9 96 1.b 2.b10 97 1.b 2.b11 98 1.b 2.c1
99 1.b 2.c2 100 1.b 2.c3 101 1.b 2.d1 102 1.b 2.d2 103 1.b 2.d3 104
1.b 2.d4 105 1.b 2.e1 106 1.b 2.e2 107 1.b 2.e3 108 1.b 2.f1 109
1.b 2.f2 110 1.b 2.f3 111 1.b 2.f4 112 1.b 2.f5 113 1.b 2.f6 114
1.b 2.f7 115 1.b 2.f8 116 1.b 2.g1 117 1.b 2.g2 118 1.b 2.g3 119
1.b 2.g4 120 1.b 2.g5 121 1.b 2.g6 122 1.b 2.g7 123 1.b 2.g8 124
1.b 2.g9 125 1.b 2.g10 126 1.b 2.h1 127 1.b 2.h2 128 1.b 2.h3 129
1.b 2.h4 130 1.b 2.h5 131 1.b 2.h6 132 1.b 2.h7 133 1.b 2.h8 134
1.b 2.h9 135 1.b 2.h10 136 1.b 2.h11 137 1.b 2.h12 138 1.b 2.h13
139 1.b 2.h14 140 1.b 2.h15 141 1.b 2.h16 142 1.b 2.i1 143 1.b 2.i2
144 1.b 2.i3 145 1.b 2.j1 146 1.b 2.j2 147 1.b 2.k1 148 1.b 2.k2
149 1.b 2.k3 150 1.b 2.k4 151 1.b 2.k5 152 1.b 2.k6 153 1.b 2.k7
154 1.b 2.k8 155 1.b 2.l1 156 1.b 2.l2 157 1.b 2.l3 158 1.b 2.m1
159 1.b 2.n1 160 1.b 2.n2 161 1.b 2.n3 162 1.b 2.o1 163 1.b 2.o2
164 1.b 2.o3 165 1.b 2.o4 166 1.b 2.o5
[0173] When this invention refers to patients requiring treatment
or prevention, it relates primarily to treatment and prevention in
humans, but the pharmaceutical composition may also be used
accordingly in veterinary medicine on mammals.
[0174] As described hereinbefore by the administration of the
pharmaceutical composition according to this invention and in
particular in view of the activity of compound 1.a and 1.b therein,
the intracellular cortisol level is reduced resulting in improved
insulin sensitivity and glucose control. Therefore a treatment or
prophylaxis according to this invention is advantageously suitable
in those patients in need of such treatment or prophylaxis who are
diagnosed of one or more of the conditions selected from the group
consisting of overweight, class I obesity, class II obesity, class
III obesity, visceral obesity and abdominal obesity or for those
individuals in which a weight increase is contraindicated.
[0175] The pharmaceutical composition according to this invention
and in particular compound 1.a and 1.b therein exhibits a very good
efficacy with regard to glycemic control, in particular in view of
a reduction of fasting plasma glucose, postprandial plasma glucose
and/or glycosylated hemoglobin (HbA1c).
[0176] Furthermore the method and/or use according to this
invention is advantageously applicable in those patients who show
one, two or more of the following conditions: [0177] (a) a fasting
blood glucose or serum glucose concentration greater than 110
mg/dL, in particular greater than 125 mg/dL; [0178] (b) a
postprandial plasma glucose equal to or greater than 140 mg/dL;
[0179] (c) an HbA1c value equal to or greater than 6.5%, in
particular equal to or greater than 8.0%.
[0180] The present invention also discloses the use of the
pharmaceutical composition for improving glycemic control in
patients having type 2 diabetes or showing first signs of
prediabetes. Thus, the invention also includes diabetes prevention.
If therefore a pharmaceutical composition according to this
invention is used to improve the glycemic control as soon as one of
the above-mentioned signs of prediabetes is present, the onset of
manifest type 2 diabetes mellitus can be delayed or prevented.
[0181] Furthermore the pharmaceutical composition according to this
invention is particularly suitable in the treatment of patients
with insulin dependency, i.e. in patients who are treated or
otherwise would be treated or need treatment with an insulin or a
derivative of insulin or a substitute of insulin or a formulation
comprising an insulin or a derivative or substitute thereof. These
patients include patients with diabetes type 2 and patients with
diabetes type 1.
[0182] It can be found that by using a pharmaceutical composition
according to this invention an improvement of the glycemic control
can be achieved even in those patients who have insufficient
glycemic control in particular despite treatment with an
antidiabetic drug, for example despite maximal tolerated dose of
oral monotherapy with either metformin or an antidiabetic of the
class of sulphonylureas. A maximal tolerated dose with regard to
metformin is for example 850 mg three times a day or any equivalent
thereof. In the scope of the present invention the term
"insufficient glycemic control" means a condition wherein patients
show HbA1c values above 6.5%, in particular above 8%.
[0183] Therefore according to a preferred embodiment of the present
invention there is provided a method for improving glycemic control
and/or for reducing of fasting plasma glucose, of postprandial
plasma glucose and/or of glycosylated hemoglobin HbA1c in a patient
in need thereof who is diagnosed with impaired glucose tolerance
(IGT), impaired fasting blood glucose (IFG) with insulin
resistance, with metabolic syndrome and/or with type 2 or type 1
diabetes mellitus characterized in that compound 1.a and/or
compound 1.b, solvates, hydrates or pharmaceutically acceptable
salts thereof as defined hereinbefore is administered in
combination or alternation with at least one second therapeutic
agent 2 as defined hereinbefore and hereinafter.
[0184] Furthermore a pharmaceutical composition according to this
invention is particularly suitable in the treatment of patients who
are diagnosed having one or more of the following conditions [0185]
(a) obesity (including class I, II and/or III obesity), visceral
obesity and/or abdominal obesity, [0186] (b) triglyceride blood
level .gtoreq.150 mg/dL, [0187] (c) HDL-cholesterol blood level
<40 mg/dL in female patients and <50 mg/dL in male patients,
[0188] (d) a systolic blood pressure .gtoreq.130 mm Hg and a
diastolic blood pressure .gtoreq.85 mm Hg, [0189] (e) a fasting
blood glucose level .gtoreq.110 mg/dL, [0190] (f) LDL-cholesterol
blood levels .gtoreq.130 mg/dL.
[0191] It is assumed that patients diagnosed with impaired glucose
tolerance (IGT), impaired fasting blood glucose (IFG), with insulin
resistance and/or with metabolic syndrome suffer from an increased
risk of developing a cardiovascular disease, such as for example
myocardial infarction, coronary heart disease, heart insufficiency,
thromboembolic events. A glycemic control according to this
invention may result in a reduction of the cardiovascular
risks.
[0192] With a pharmaceutical composition according to this
invention treatment or prophylaxis according to this invention may
be advantageous possible in those patients for which the
mono-therapy with another antidiabetic drug, such as for example
metformin, is contraindicated and/or who have an intolerance
against such drugs at therapeutic doses. In particular a treatment
or prophylaxis according to this invention may be advantageous
possible in those patients showing or having an increased risk for
one or more of the following disorders: renal insufficiency or
diseases, cardiac diseases, cardiac failure, hepatic diseases,
pulmonal diseases, catabolytic states and/or danger of lactate
acidosis, or female patients being pregnant or during
lactation.
[0193] Furthermore it may be found that the administration of a
pharmaceutical composition according to this invention results in
no risk or in a low risk of hypoglycemia. Therefore a treatment or
prophylaxis according to this invention may also advantageously
possible in those patients showing or having an increased risk for
hypoglycemia.
[0194] A pharmaceutical composition according to this invention is
particularly suitable in the long term treatment or prophylaxis of
the diseases and/or conditions as described hereinbefore and
hereinafter, in particular in the long term glycemic control in
patients with type 2 diabetes mellitus.
[0195] The term "long term" as used hereinbefore and hereinafter
indicates a treatment of or administration in a patient within a
period of time longer than 12 weeks, preferably longer than 25
weeks, even more preferably longer than 1 year.
[0196] Therefore a particularly preferred embodiment of the present
invention provides a method for therapy, preferably oral therapy,
for improvement, especially long term improvement, of glycemic
control in patients with type 2 diabetes mellitus, especially in
patients with late stage type 2 diabetes mellitus, in particular in
patients additionally diagnosed of overweight, obesity (including
class I, class II and/or class III obesity), visceral obesity
and/or abdominal obesity.
[0197] Administration of compound 1.a and/or compound 1.b,
solvates, hydrates or pharmaceutically acceptable salts thereof
according to this invention in combination with at least one second
therapeutic agent 2 can have an additive or over-additive effect
and provide for dose reduction, side-effect reduction and/or
interval extension when compared to the individual compound 1.a
and/or compound 1.b or to the individual second therapeutic agent 2
used in monotherapy in the usual way. The effects mentioned above
are observed both when compound 1.a and/or compound 1.b and the
second therapeutic agent 2 are administered in combination, for
example simultaneously, and when they are administered in
alternation, for example successively in separate formulations. In
the case of the second therapeutic agent being an injectable,
especially a biological agent, other benefits of a combination with
the compound 1.a and/or compound 1.b may be seen, as for example,
cost reduction by way of interval and/or dose reduction.
[0198] It will be appreciated that the amount of the pharmaceutical
composition according to this invention to be administered to the
patient and required for use in treatment or prophylaxis according
to the present invention will vary with the route of
administration, the nature and severity of the condition for which
treatment or prophylaxis is required, the age, weight and condition
of the patient, concomitant medication and will be ultimately at
the discretion of the attendant physician. In general however the
compound 1.a and/or compound 1.b according to this invention, and
the at least one second therapeutic agent 2 are included in the
pharmaceutical composition or dosage form in an amount sufficient
that by their administration in combination or alternation the
glycemic control in the patient to be treated is improved.
[0199] In the following preferred ranges of the amount of compound
1.a and/or compound 1.b and of the second therapeutic agent 2 to be
employed in the pharmaceutical composition and the methods and uses
according to this invention are described. These ranges refer to
the amounts to be administered per day with respect to an adult
patient and can be adapted accordingly with regard to an
administration 2, 3, 4 or more times daily and with regard to other
routes of administration and with regard to the age of the
patient.
[0200] Within the scope of the present invention the pharmaceutical
composition (with the exception of insulins and GLP-1 agonists) is
preferably administered orally. Other forms of administration are
possible and described hereinafter. Preferably the dosage form
comprising the compound 1.a and/or compound 1.b is administered
orally. The route of administration of the 2.sup.nd therapeutic
agent is usually well known.
[0201] In general the amount of the compound 1.a and/or compound
1.b in the pharmaceutical composition and methods according to this
invention is preferably in the range from 1/10 to 1/1 of the amount
usually recommended for a monotherapy using said compounds.
[0202] Advantageously, the combination therapy according to the
present invention utilizes lower dosages of the individual compound
1.a and compound 1.b or of the individual second therapeutic agent
2 used in monotherapy or used in conventional therapeutics, thus
avoiding possible toxicity and adverse side effects incurred when
those agents are used as monotherapies.
[0203] The amount of compound 1.a and compound 1.b is preferably in
the range from 0.1 mg to 1000 mg or 0.1 to 100 mg, even more
preferably from 1 to 50 mg or 2 to 50 mg per day. The oral
administration is preferred. Therefore a pharmaceutical composition
may comprise the hereinbefore mentioned amounts for once daily
administration and from 0.05 mg to 500 mg, even more preferably
from 0.05 to 50 mg or 0.5 to 25 mg for twice daily
administration.
[0204] In general the amount of the second therapeutic agent 2 in
the pharmaceutical composition and methods according to this
invention is preferably in the range from 1/5 to 1/1 of the amount
usually recommended for a monotherapy using said second therapeutic
agent.
[0205] A preferred dosage range of metformin is 100 to 4000 mg, in
particular 200 to 3500 mg, most preferably 500 to 3000 mg per day.
The preferred range of amounts in the pharmaceutical composition
for an administration once, twice or three times daily is 100 to
3000, 50 to 1500 and 35 to 1000 mg respectively. Examples are 500
or 850 mg once, twice or three times daily, 1000 mg once or twice
daily or 2000 mg once daily.
[0206] A preferred dosage range of pioglitazone is 5 to 50 mg per
day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 5 to 50, 2 to 25 and 2 to 20 mg respectively. Examples are 15,
30 or 45 mg once daily.
[0207] A preferred dosage range of a rosiglitazone is 1 mg to 10 mg
per day. The preferred range of amounts in the pharmaceutical
composition for an administration once or twice times daily is 4 to
8 mg and 4 mg respectively.
[0208] A preferred dosage range of a thiazolidindione (other than
pioglitazone or rosiglitazone as described above) is 2 to 100 mg
per day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 2 to 100, 1 to 50 and 1 to 33 mg respectively.
[0209] A preferred dosage range of miglitol is 10 to 300 mg per
day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 10 to 300, 5 to 150 and 3 to 100 mg respectively. Examples are
50 or 100 mg once, twice or three times daily.
[0210] A preferred dosage range of glibenclamide is 1 to 20 mg per
day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 1 to 20, 0.5 to 10 and 0.5 to 7 mg respectively.
[0211] A preferred dosage range of tolbutamide is 100 to 3000 mg,
preferably 500 to 3000 mg per day. The preferred range of amounts
in the pharmaceutical composition for an administration once, twice
or three times daily is 100 to 3000, 50 to 1500 and 35 to 1000 mg
respectively.
[0212] A preferred dosage range of glimepiride is 0.5 to 10 mg, in
particular 1 to 6 mg per day. The preferred range of amounts in the
pharmaceutical composition for an administration once, twice or
three times daily is 0.5 to 10, 0.25 to 5 and 0.2 to 3 mg
respectively.
[0213] A preferred dosage range of glipizid is 1 to 50 mg, in
particular 2.5 to 40 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 1 to 50, 0.5 to 25 and 0.3 to 17 mg
respectively.
[0214] A preferred dosage range of gliquidon is 10 to 150 mg, in
particular 30 to 120 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 10 to 150, 5 to 75 and 3 to 50 mg
respectively.
[0215] A preferred dosage range of glibornurid is 5 to 75 mg per
day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 5 to 75, 3 to 40 and 2 to 25 mg respectively.
[0216] A preferred dosage range of gliclazid is 25 to 320 mg, in
particular 80 to 160 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 25 to 320, 12 to 160 and 10 to 80 mg
respectively.
[0217] A preferred dosage range of nateglinide is 15 to 540 mg, in
particular 60 to 360 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 15 to 360, 7 to 180 and 5 to 120 mg
respectively.
[0218] A preferred dosage range of repaglinide is 0.1 to 16 mg, in
particular 0.5 to 12 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 0.1 to 16, 0.05 to 8 and 0.03 to 5 mg
respectively.
[0219] A preferred dosage range of metaglidasen is 40 to 600 mg, in
particular 200 to 600 mg per day. The preferred range of amounts in
the pharmaceutical composition for an administration once, twice or
three times daily is 40 to 600, 20 to 300 and 15 to 200 mg
respectively.
[0220] A preferred dosage range of a PPAR gamma/alpha modulator is
0.5 to 10 mg, in particular 2.5 to 5 mg per day. The preferred
range of amounts in the pharmaceutical composition for an
administration once, twice or three times daily is 0.5 to 10, 0.2
to 5 and 0.1 to 3 mg respectively.
[0221] A preferred dosage range of a pramlintide is 15 .mu.g to 120
.mu.g per day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 15 to 120, 8 to 60 and 5 to 40 .mu.g respectively.
[0222] A preferred dosage range of an alpha glucosidase inhibitor
is 0.1 to 500 mg per day. The preferred range of amounts in the
pharmaceutical composition for an administration once, twice or
three times daily is 0.1 to 500, 0.05 to 250 and 0.03 to 133 mg
respectively.
[0223] A preferred dosage range of a voglibose is 0.1 to 2.0 mg per
day, in particular 0.2 to 1.0 mg per day. The preferred range of
amounts in the pharmaceutical composition for an administration
twice or three times daily is 0.1 to 0.5 and 0.1 to 0.3 mg
respectively.
[0224] A preferred dosage range of a acarbose is 50 to 300 mg per
day, in particular 150 to 300 mg per day. The preferred range of
amounts in the pharmaceutical composition for an administration
twice or three times daily is 100 to 150 and 50 to 100 mg
respectively. Examples are 50 or 100 mg twice or three times
daily.
[0225] A preferred dosage range of a insulin is 1 to 250 IU per
day. The preferred range of amounts in the pharmaceutical
composition for an administration once, twice or three times daily
is 1 to 250, 0.5 to 125 and 0.3 to 90 IU respectively. The term
"IU" means international units.
[0226] A preferred dosage range of a linagliptine is 1 to 10 mg per
day, in particular 3 to 6 mg per day. The preferred range of
amounts in the pharmaceutical composition for an administration
twice or three times daily is 1 to 5 and 2 to 3 mg
respectively.
[0227] A preferred dosage range of a compound of group 2.h) is 1 to
100 mg per day, in particular 5 to 50 mg per day more preferably 10
to 25 mg. The preferred range of amounts in the pharmaceutical
composition for an administration twice or three times daily is 5
to 50 and 10 to 25 mg respectively.
[0228] The amount of 1.a and/or 1.b and of the second therapeutic
agent 2 in the pharmaceutical composition according to this
invention correspond to the respective dosage ranges as provided
hereinbefore. For example a pharmaceutical composition comprises an
amount of 2.5 to 100 mg of 1.a and/or 1.b and metformin in an
amount of 50 to 1500 mg.
[0229] In the methods and uses according to the present invention
1.a and/or 1.b and the at least one second therapeutic 2 ingredient
are administered in combination or alternation. The term
"administration in combination" means that both active ingredients
are administered at the same time, i.e. simultaneously, or
essentially at the same time. The term "administration in
alternation" means that at first a first active ingredient is
administered and after a period of time the second active
ingredient is administered, i.e. both active ingredients are
administered sequentially. The period of time may be in the range
from 30 min to 12 hours. The administration which is in combination
or in alternation may be once, twice, three times or four times
daily.
[0230] With regard to the administration of 1.a and/or 1.b in
combination with the at least one second therapeutic ingredient 2
all active ingredients may be present in a single dosage form, for
example in a tablet or capsule, or each active ingredient may be
present in a separate dosage form, for example in two different or
identical dosage forms.
[0231] With regard to their administration in alternation each of
the active ingredients is present in a separate dosage form, for
example in two different or identical dosage forms.
[0232] Therefore the pharmaceutical composition according to this
invention may be present as single dosage forms which comprise both
1.a and/or 1.b and the at least one second therapeutic ingredient 2
as well as separate dosage forms wherein one dosage form comprises
1.a and/or 1.b and the other dosage form comprises the at least one
second therapeutic ingredient 2.
[0233] The case may arise in which one active ingredient has to be
administered more often, for example twice per day, than the other
active ingredient, which for example needs administration once
daily. Therefore the term "administration in combination or
alternation" also includes an administration scheme in which first
both active ingredients are administered in combination or
alternation and after a period of time only one active ingredient
is administered again or vice versa.
[0234] Therefore the present invention also includes pharmaceutical
compositions which are present a separate dosage forms wherein one
dosage form comprises 1.a and/or 1.b and the second therapeutic
agent 2 and the other dosage form comprises either 1.a and/or 1.b
or the at least one second therapeutic agent 2.
[0235] A pharmaceutical composition which is present as a separate
or multiple dosage form, preferably as a kit of parts, is useful in
combination therapy to flexibly suit the individual therapeutic
needs of the patient.
[0236] A preferred kit of parts comprises [0237] (a) a first
containment containing a dosage form comprising 1.a and/or 1.b and
at least one pharmaceutically acceptable carrier, and [0238] (b) a
second containment containing a dosage form comprising the at least
one second therapeutic agent 2 and at least one pharmaceutically
acceptable carrier.
[0239] A further aspect of the present invention is a manufacture
comprising the pharmaceutical composition being present as separate
dosage forms according to the present invention and a label or
package insert comprising instructions that the separate dosage
forms are to be administered in combination or alternation.
[0240] A yet further aspect of the present invention is a
manufacture comprising a medicament which comprises 1.a and/or 1.b
according to the present invention and a label or package insert
which comprises instructions that the medicament may or is to be
administered in combination or alternation with a medicament
comprising at least one second therapeutic agent 2 according to the
present invention.
[0241] Another further aspect of the present invention is a
manufacture comprising a medicament which comprises at least one
second therapeutic agent 2 according to the present invention and a
label or package insert which comprises instructions that the
medicament may or is to be administered in combination or
alternation with a medicament comprising 1.a and/or 1.b according
to the present invention.
[0242] The desired dose of the pharmaceutical composition according
to this invention may conveniently be presented in a once daily or
as divided dose administered at appropriate intervals, for example
as two, three or more doses per day.
[0243] The pharmaceutical composition may be formulated for oral,
rectal, nasal, topical (including buccal and sublingual),
transdermal, vaginal or parenteral (including intramuscular,
sub-cutaneous and intravenous) administration in liquid or solid
form or in a form suitable for administration by inhalation or
insufflation. Oral administration is preferred. The formulations
may, where appropriate, be conveniently presented in discrete
dosage units and may be prepared by any of the methods well known
in the art of pharmacy. All methods include the step of bringing
into association the active ingredient with one or more
pharmaceutically acceptable carriers, like liquid carriers or
finely divided solid carriers or both, and then, if necessary,
shaping the product into the desired formulation.
[0244] The pharmaceutical composition may be formulated in the form
of tablets, granules, fine granules, powders, capsules, caplets,
soft capsules, pills, oral solutions, syrups, dry syrups, chewable
tablets, troches, effervescent tablets, drops, suspension, fast
dissolving tablets, oral fast-dispersing tablets, etc.
[0245] The pharmaceutical composition and the dosage forms
preferably comprises one or more pharmaceutical acceptable carriers
which must be "acceptable" in the sense of being compatible with
the other ingredients of the formulation and not deleterious to the
recipient thereof.
[0246] Pharmaceutical compositions suitable for oral administration
may conveniently be presented as discrete units such as capsules,
including soft gelatin capsules, cachets or tablets each containing
a predetermined amount of the active ingredient; as a powder or
granules; as a solution, a suspension or as an emulsion, for
example as syrups, elixirs or self-emulsifying delivery systems
(SEDDS). The active ingredients may also be presented as a bolus,
electuary or paste. Tablets and capsules for oral administration
may contain conventional excipients such as binding agents,
fillers, lubricants, disintegrants, or wetting agents. The tablets
may be coated according to methods well known in the art. Oral
liquid preparations may be in the form of, for example, aqueous or
oily suspensions, solutions, emulsions, syrups or elixirs, or may
be presented as a dry product for constitution with water or other
suitable vehicle before use. Such liquid preparations may contain
conventional additives such as suspending agents, emulsifying
agents, non-aqueous vehicles (which may include edible oils), or
preservatives.
[0247] The pharmaceutical composition according to the invention
may also be formulated for parenteral administration (e.g. by
injection, for example bolus injection or continuous infusion) and
may be presented in unit dose form in ampoules, pre-filled
syringes, small volume infusion or in multi-dose containers with an
added preservative. The compositions may take such forms as
suspensions, solutions, or emulsions in oily or aqueous vehicles,
and may contain formulatory agents such as suspending, stabilizing
and/or dispersing agents. Alternatively, the active ingredients may
be in powder form, obtained by aseptic isolation of sterile solid
or by lyophilisation from solution, for constitution with a
suitable vehicle, e.g. sterile, pyrogen-free water, before use.
[0248] Pharmaceutical compositions suitable for rectal
administration wherein the carrier is a solid are most preferably
presented as unit dose suppositories. Suitable carriers include
cocoa butter and other materials commonly used in the art, and the
suppositories may be conveniently formed by admixture of the active
compound(s) with the softened or melted carrier(s) followed by
chilling and shaping in moulds.
[0249] The pharmaceutical compositions and methods according to
this invention show advantageous effects in the treatment and
prevention of those diseases and conditions as described
hereinbefore compared with pharmaceutical compositions and methods
which comprise only one of both active ingredients. Advantageous
effect may be seen for example with respect to efficacy, dosage
strength, dosage frequency, pharmacodynamic properties,
pharmacokinetic properties, adverse effects, etc.
[0250] Any of the above mentioned combinations within the scope of
the invention may be tested by animal models known in the art. In
the following in vivo experiments are described which are suitable
to evaluate pharmacologically relevant properties of pharmaceutical
compositions and methods according to this invention:
[0251] Pharmaceutical compositions and methods according to this
invention can be tested in hyperinsulinemic or diabetic non-human
primates.
[0252] The effect on glycemic control of the combinations according
to this invention can be tested after single or multiple dosing of
1.a and/or 1.b and a second therapeutic agent 2 alone and in
combination in the animal models described hereinbefore by
following mean fasting plasma glucose. The combinations according
to the present invention significantly reduce mean fasting glucose
compared to each monotherapy. In addition, after multiple dosing of
1.a and/or 1.b and a second therapeutic agent 2 alone and in
combination in the animal models described hereinbefore, the effect
on glycemic control can be determined by measuring the HbA1c or
fructosamine values in blood. The combinations according to this
invention significantly reduce HbA1c or fructosamine compared to
each monotherapy.
[0253] The possible dose reduction of either 1.a and/or 1.b or the
second therapeutic agent 2 or of both active ingredients can be
tested by the effect on glycemic control of lower doses of the
combinations and monotherapies in the animal models described
hereinbefore. The combinations according to this invention at the
lower doses significantly improve glycemic control compared to
placebo treatment whereas the monotherapies at lower doses do
not.
[0254] Examples of pharmaceutically acceptable carriers are known
to the one skilled in the art.
[0255] Methods for the manufacture of 1.a and/or 1.b according to
this invention are known to the one skilled in the art. The
compounds according to this invention can be prepared using
synthetic methods as described in the literature, in particular as
described in WO 09/134400 and WO 10/011314.
[0256] The methods of synthesis for the second therapeutic agent 2
are described in the scientific literature and/or in published
patent documents.
[0257] 1.a and/or 1.b and/or the second therapeutic agent 2 may be
present in the form of a pharmaceutically acceptable salt.
Pharmaceutically acceptable salts include such as salts of
inorganic acid like hydrochloric acid, sulfuric acid and phosphoric
acid; salts of organic carboxylic acid like oxalic acid, acetic
acid, citric acid, malic acid, benzoic acid, maleic acid, fumaric
acid, tartaric acid, succinic acid and glutamic acid and salts of
organic sulfonic acid like methanesulfonic acid and
p-toluenesulfonic acid. The salts can be formed by combining the
compound and an acid in the appropriate amount and ratio in a
solvent and decomposer. They can be also obtained by the cation or
anion exchange from the form of other salts.
[0258] 1.a and/or 1.b and/or the second therapeutic agent 2 or a
pharmaceutically acceptable salt thereof may be present in the form
of a solvate such as a hydrate or alcohol adduct.
[0259] The biological properties of 1.a and/or 1.b may be
investigated as it is described for example in WO 09/134400 and WO
10/011314.
EXAMPLES OF FORMULATIONS
[0260] The following examples of formulations, which may be
obtained analogously to methods known in the art, serve to
illustrate the present invention more fully without restricting it
to the contents of these examples. The term "active substance"
denotes one or more compounds according to the invention, i.e.
denotes 1.a and/or 1.b according to this invention or a second
therapeutic agent 2 according to this invention or a combination of
1.a and/or 1.b with said second therapeutic agent 2, for example
selected from the combinations 1 a to 7h as listed in Table 1.
Additional suitable formulations for the second therapeutic agent 2
may be those formulations which are available on the market or
formulations described in the literature, for example as disclosed
in current issues of "Rote Liste.RTM." (Editio Cantor Verlag
Aulendorf, Germany) or of "Physician's Desk Reference".
Example 1
Dry Ampoule Containing 75 mg of Active Substance Per 10 ml
[0261] Composition:
TABLE-US-00002 Active substance 75.0 mg Mannitol 50.0 mg water for
injections ad 10.0 ml
[0262] Preparation:
[0263] Active substance and mannitol are dissolved in water. After
packaging the solution is freeze-dried. To produce the solution
ready for use, the product is dissolved in water for
injections.
Example 2
Dry Ampoule Containing 35 mg of Active Substance Per 2 ml
[0264] Composition:
TABLE-US-00003 Active substance 35.0 mg Mannitol 100.0 mg water for
injections ad 2.0 ml
[0265] Preparation:
[0266] Active substance and mannitol are dissolved in water. After
packaging, the solution is freeze-dried.
[0267] To produce the solution ready for use, the product is
dissolved in water for injections.
Example 3
Tablet Containing 50 mg of Active Substance
[0268] Composition:
TABLE-US-00004 (1) Active substance 50.0 mg (2) Lactose 98.0 mg (3)
Maize starch 50.0 mg (4) Polyvinylpyrrolidone 15.0 mg (5) Magnesium
stearate 2.0 mg 215.0 mg
[0269] Preparation:
[0270] (1), (2) and (3) are mixed together and granulated with an
aqueous solution of (4). (5) is added to the dried granulated
material. From this mixture tablets are pressed, biplanar, faceted
on both sides and with a dividing notch on one side.
[0271] Diameter of the tablets: 9 mm.
Example 4
Tablet Containing 350 mg of Active Substance
[0272] Preparation:
TABLE-US-00005 (1) Active substance 350.0 mg (2) Lactose 136.0 mg
(3) Maize starch 80.0 mg (4) Polyvinylpyrrolidone 30.0 mg (5)
Magnesium stearate 4.0 mg 600.0 mg
[0273] (1), (2) and (3) are mixed together and granulated with an
aqueous solution of (4). (5) is added to the dried granulated
material. From this mixture tablets are pressed, biplanar, faceted
on both sides and with a dividing notch on one side.
[0274] Diameter of the tablets: 12 mm.
Example 5
Capsules Containing 50 mg of Active Substance
[0275] Composition:
TABLE-US-00006 (1) Active substance 50.0 mg (2) Dried maize starch
58.0 mg (3) Powdered lactose 50.0 mg (4) Magnesium stearate 2.0 mg
160.0 mg
[0276] Preparation:
[0277] (1) is triturated with (3). This trituration is added to the
mixture of (2) and (4) with vigorous mixing. This powder mixture is
packed into size 3 hard gelatin capsules in a capsule filling
machine.
Example 6
Capsules Containing 350 mg of Active Substance
[0278] Composition:
TABLE-US-00007 (1) Active substance 350.0 mg (2) Dried maize starch
46.0 mg (3) Powdered lactose 30.0 mg (4) Magnesium stearate 4.0 mg
430.0 mg
[0279] Preparation:
[0280] (1) is triturated with (3). This trituration is added to the
mixture of (2) and (4) with vigorous mixing. This powder mixture is
packed into size 0 hard gelatin capsules in a capsule filling
machine.
Example 7
Suppositories Containing 100 mg of Active Substance
[0281] Composition:
TABLE-US-00008 Active substance 100.0 mg Polyethyleneglycol (M.W.
1500) 600.0 mg Polyethyleneglycol (M.W. 6000) 460.0 mg
Polyethylenesorbitan monostearate 840.0 mg 2,000.0 mg
* * * * *