U.S. patent application number 13/453090 was filed with the patent office on 2012-10-18 for interleukin-21 receptor binding proteins. This patent application is currently assigned to MEDIMMUNE LIMITED. Invention is credited to Laird BLOOM, Davinder GILL, David LOWE, Viia VALGE-ARCHER, Yulia VUGMEYSTER, Deborah A. YOUNG.
Application Number | 20120264919 13/453090 |
Document ID | / |
Family ID | 41112652 |
Filed Date | 2012-10-18 |
United States Patent Application | 20120264919 |
Kind Code | A1 |
BLOOM; Laird ; et al. | October 18, 2012 |
The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
Inventors: | BLOOM; Laird; (Needham, MA) ; GILL; Davinder; (Andover, MA) ; VUGMEYSTER; Yulia; (North Reading, MA) ; YOUNG; Deborah A.; (Melrose, MA) ; LOWE; David; (Cambridge, GB) ; VALGE-ARCHER; Viia; (Cambridge, GB) |
Assignee: | MEDIMMUNE LIMITED Cambridge NJ WYETH LLC Madison |
Family ID: | 41112652 |
Appl. No.: | 13/453090 |
Filed: | April 23, 2012 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12472209 | May 26, 2009 | 8163884 | ||
13453090 | ||||
61055500 | May 23, 2008 | |||
Current U.S. Class: | 530/387.9 ; 435/252.3; 435/254.2; 435/320.1; 435/331; 435/419; 536/23.53 |
Current CPC Class: | C07K 2317/622 20130101; A61P 29/00 20180101; A61P 37/08 20180101; C07K 2317/732 20130101; C07K 16/2866 20130101; A61P 37/06 20180101; C07K 2317/92 20130101; C07K 2317/21 20130101; A61P 43/00 20180101; C07K 14/54 20130101; C07K 2317/52 20130101; C07K 2317/73 20130101; C07K 2317/565 20130101 |
Class at Publication: | 530/387.9 ; 536/23.53; 435/320.1; 435/331; 435/252.3; 435/254.2; 435/419 |
International Class: | C07K 16/28 20060101 C07K016/28; C12N 1/19 20060101 C12N001/19; C12N 5/10 20060101 C12N005/10; C12N 1/21 20060101 C12N001/21; C12N 15/13 20060101 C12N015/13; C12N 15/63 20060101 C12N015/63 |
Sequence CWU 1
1
24812665DNAHomo sapiensCDS(236)..(1849) 1gtcgactgga ggcccagctg
cccgtcatca gagtgacagg tcttatgaca gcctgattgg 60tgactcgggc tgggtgtgga
ttctcacccc aggcctctgc ctgctttctc agaccctcat 120ctgtcacccc
cacgctgaac ccagctgcca cccccagaag cccatcagac tgcccccagc
180acacggaatg gatttctgag aaagaagccg aaacagaagg cccgtgggag tcagc atg
238 Met 1ccg cgt ggc tgg gcc gcc ccc ttg ctc ctg ctg ctg ctc cag
gga ggc 286Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln
Gly Gly 5 10 15tgg ggc tgc ccc gac ctc gtc tgc tac acc gat tac ctc
cag acg gtc 334Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu
Gln Thr Val 20 25 30atc tgc atc ctg gaa atg tgg aac ctc cac ccc agc
acg ctc acc ctt 382Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser
Thr Leu Thr Leu 35 40 45acc tgg caa gac cag tat gaa gag ctg aag gac
gag gcc acc tcc tgc 430Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp
Glu Ala Thr Ser Cys50 55 60 65agc ctc cac agg tcg gcc cac aat gcc
acg cat gcc acc tac acc tgc 478Ser Leu His Arg Ser Ala His Asn Ala
Thr His Ala Thr Tyr Thr Cys 70 75 80cac atg gat gta ttc cac ttc atg
gcc gac gac att ttc agt gtc aac 526His Met Asp Val Phe His Phe Met
Ala Asp Asp Ile Phe Ser Val Asn 85 90 95atc aca gac cag tct ggc aac
tac tcc cag gag tgt ggc agc ttt ctc 574Ile Thr Asp Gln Ser Gly Asn
Tyr Ser Gln Glu Cys Gly Ser Phe Leu 100 105 110ctg gct gag agc atc
aag ccg gct ccc cct ttc aac gtg act gtg acc 622Leu Ala Glu Ser Ile
Lys Pro Ala Pro Pro Phe Asn Val Thr Val Thr 115 120 125ttc tca gga
cag tat aat atc tcc tgg cgc tca gat tac gaa gac cct 670Phe Ser Gly
Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp Pro130 135 140
145gcc ttc tac atg ctg aag ggc aag ctt cag tat gag ctg cag tac agg
718Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr Arg
150 155 160aac cgg gga gac ccc tgg gct gtg agt ccg agg aga aag ctg
atc tca 766Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu
Ile Ser 165 170 175gtg gac tca aga agt gtc tcc ctc ctc ccc ctg gag
ttc cgc aaa gac 814Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu
Phe Arg Lys Asp 180 185 190tcg agc tat gag ctg cag gtg cgg gca ggg
ccc atg cct ggc tcc tcc 862Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly
Pro Met Pro Gly Ser Ser 195 200 205tac cag ggg acc tgg agt gaa tgg
agt gac ccg gtc atc ttt cag acc 910Tyr Gln Gly Thr Trp Ser Glu Trp
Ser Asp Pro Val Ile Phe Gln Thr210 215 220 225cag tca gag gag tta
aag gaa ggc tgg aac cct cac ctg ctg ctt ctc 958Gln Ser Glu Glu Leu
Lys Glu Gly Trp Asn Pro His Leu Leu Leu Leu 230 235 240ctc ctg ctt
gtc ata gtc ttc att cct gcc ttc tgg agc ctg aag acc 1006Leu Leu Leu
Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys Thr 245 250 255cat
cca ttg tgg agg cta tgg aag aag ata tgg gcc gtc ccc agc cct 1054His
Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro 260 265
270gag cgg ttc ttc atg ccc ctg tac aag ggc tgc agc gga gac ttc aag
1102Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys
275 280 285aaa tgg gtg ggt gca ccc ttc act ggc tcc agc ctg gag ctg
gga ccc 1150Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu
Gly Pro290 295 300 305tgg agc cca gag gtg ccc tcc acc ctg gag gtg
tac agc tgc cac cca 1198Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val
Tyr Ser Cys His Pro 310 315 320cca cgg agc ccg gcc aag agg ctg cag
ctc acg gag cta caa gaa cca 1246Pro Arg Ser Pro Ala Lys Arg Leu Gln
Leu Thr Glu Leu Gln Glu Pro 325 330 335gca gag ctg gtg gag tct gac
ggt gtg ccc aag ccc agc ttc tgg ccg 1294Ala Glu Leu Val Glu Ser Asp
Gly Val Pro Lys Pro Ser Phe Trp Pro 340 345 350aca gcc cag aac tcg
ggg ggc tca gct tac agt gag gag agg gat cgg 1342Thr Ala Gln Asn Ser
Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg 355 360 365cca tac ggc
ctg gtg tcc att gac aca gtg act gtg cta gat gca gag 1390Pro Tyr Gly
Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu370 375 380
385ggg cca tgc acc tgg ccc tgc agc tgt gag gat gac ggc tac cca gcc
1438Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala
390 395 400ctg gac ctg gat gct ggc ctg gag ccc agc cca ggc cta gag
gac cca 1486Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu
Asp Pro 405 410 415ctc ttg gat gca ggg acc aca gtc ctg tcc tgt ggc
tgt gtc tca gct 1534Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly
Cys Val Ser Ala 420 425 430ggc agc cct ggg cta gga ggg ccc ctg gga
agc ctc ctg gac aga cta 1582Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly
Ser Leu Leu Asp Arg Leu 435 440 445aag cca ccc ctt gca gat ggg gag
gac tgg gct ggg gga ctg ccc tgg 1630Lys Pro Pro Leu Ala Asp Gly Glu
Asp Trp Ala Gly Gly Leu Pro Trp450 455 460 465ggt ggc cgg tca cct
gga ggg gtc tca gag agt gag gcg ggc tca ccc 1678Gly Gly Arg Ser Pro
Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro 470 475 480ctg gcc ggc
ctg gat atg gac acg ttt gac agt ggc ttt gtg ggc tct 1726Leu Ala Gly
Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser 485 490 495gac
tgc agc agc cct gtg gag tgt gac ttc acc agc ccc ggg gac gaa 1774Asp
Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu 500 505
510gga ccc ccc cgg agc tac ctc cgc cag tgg gtg gtc att cct ccg cca
1822Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro
515 520 525ctt tcg agc cct gga ccc cag gcc agc taatgaggct
gactggatgt 1869Leu Ser Ser Pro Gly Pro Gln Ala Ser530 535ccagagctgg
ccaggccact gggccctgag ccagagacaa ggtcacctgg gctgtgatgt
1929gaagacacct gcagcctttg gtctcctgga tgggcctttg agcctgatgt
ttacagtgtc 1989tgtgtgtgtg tgtgcatatg tgtgtgtgtg catatgcatg
tgtgtgtgtg tgtgtgtctt 2049aggtgcgcag tggcatgtcc acgtgtgtgt
gtgattgcac gtgcctgtgg gcctgggata 2109atgcccatgg tactccatgc
attcacctgc cctgtgcatg tctggactca cggagctcac 2169ccatgtgcac
aagtgtgcac agtaaacgtg tttgtggtca acagatgaca acagccgtcc
2229tccctcctag ggtcttgtgt tgcaagttgg tccacagcat ctccggggct
ttgtgggatc 2289agggcattgc ctgtgactga ggcggagccc agccctccag
cgtctgcctc caggagctgc 2349aagaagtcca tattgttcct tatcacctgc
caacaggaag cgaaagggga tggagtgagc 2409ccatggtgac ctcgggaatg
gcaatttttt gggcggcccc tggacgaagg tctgaatccc 2469gactctgata
ccttctggct gtgctacctg agccaagtcg cctcccctct ctgggctaga
2529gtttccttat ccagacagtg gggaaggcat gacacacctg ggggaaattg
gcgatgtcac 2589ccgtgtacgg tacgcagccc agagcagacc ctcaataaac
gtcagcttcc ttcaaaaaaa 2649aaaaaaaaaa tctaga 26652538PRTHomo sapiens
2Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly1 5
10 15Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln
Thr 20 25 30Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr
Leu Thr 35 40 45Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu
Ala Thr Ser 50 55 60Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His
Ala Thr Tyr Thr65 70 75 80Cys His Met Asp Val Phe His Phe Met Ala
Asp Asp Ile Phe Ser Val 85 90 95Asn Ile Thr Asp Gln Ser Gly Asn Tyr
Ser Gln Glu Cys Gly Ser Phe 100 105 110Leu Leu Ala Glu Ser Ile Lys
Pro Ala Pro Pro Phe Asn Val Thr Val 115 120 125Thr Phe Ser Gly Gln
Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 130 135 140Pro Ala Phe
Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr145 150 155
160Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile
165 170 175Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe
Arg Lys 180 185 190Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro
Met Pro Gly Ser 195 200 205Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser
Asp Pro Val Ile Phe Gln 210 215 220Thr Gln Ser Glu Glu Leu Lys Glu
Gly Trp Asn Pro His Leu Leu Leu225 230 235 240Leu Leu Leu Leu Val
Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 245 250 255Thr His Pro
Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 260 265 270Pro
Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 275 280
285Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly
290 295 300Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser
Cys His305 310 315 320Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu
Thr Glu Leu Gln Glu 325 330 335Pro Ala Glu Leu Val Glu Ser Asp Gly
Val Pro Lys Pro Ser Phe Trp 340 345 350Pro Thr Ala Gln Asn Ser Gly
Gly Ser Ala Tyr Ser Glu Glu Arg Asp 355 360 365Arg Pro Tyr Gly Leu
Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 370 375 380Glu Gly Pro
Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro385 390 395
400Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp
405 410 415Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys
Val Ser 420 425 430Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser
Leu Leu Asp Arg 435 440 445Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp
Trp Ala Gly Gly Leu Pro 450 455 460Trp Gly Gly Arg Ser Pro Gly Gly
Val Ser Glu Ser Glu Ala Gly Ser465 470 475 480Pro Leu Ala Gly Leu
Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 485 490 495Ser Asp Cys
Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 500 505 510Glu
Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 515 520
525Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 530 53532628DNAMus
musculusCDS(407)..(1993) 3gtcgacgcgg cggtaccagc tgtctgccca
cttctcctgt ggtgtgcctc acggtcactt 60gcttgtctga ccgcaagtct gcccatccct
ggggcagcca actggcctca gcccgtgccc 120caggcgtgcc ctgtctctgt
ctggctgccc cagccctact gtcttcctct gtgtaggctc 180tgcccagatg
cccggctggt cctcagcctc aggactatct cagcagtgac tcccctgatt
240ctggacttgc acctgactga actcctgccc acctcaaacc ttcacctccc
accaccacca 300ctccgagtcc cgctgtgact cccacgccca ggagaccacc
caagtgcccc agcctaaaga 360atggctttct gagaaagacc ctgaaggagt
aggtctggga cacagc atg ccc cgg 415 Met Pro Arg 1ggc cca gtg gct gcc
tta ctc ctg ctg att ctc cat gga gct tgg agc 463Gly Pro Val Ala Ala
Leu Leu Leu Leu Ile Leu His Gly Ala Trp Ser 5 10 15tgc ctg gac ctc
act tgc tac act gac tac ctc tgg acc atc acc tgt 511Cys Leu Asp Leu
Thr Cys Tyr Thr Asp Tyr Leu Trp Thr Ile Thr Cys20 25 30 35gtc ctg
gag aca cgg agc ccc aac ccc agc ata ctc agt ctc acc tgg 559Val Leu
Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser Leu Thr Trp 40 45 50caa
gat gaa tat gag gaa ctt cag gac caa gag acc ttc tgc agc cta 607Gln
Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe Cys Ser Leu 55 60
65cac agg tct ggc cac aac acc aca cat ata tgg tac acg tgc cat atg
655His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr Cys His Met
70 75 80cgc ttg tct caa ttc ctg tcc gat gaa gtt ttc att gtc aat gtg
acg 703Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val Asn Val
Thr 85 90 95gac cag tct ggc aac aac tcc caa gag tgt ggc agc ttt gtc
ctg gct 751Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe Val
Leu Ala100 105 110 115gag agc atc aaa cca gct ccc ccc ttg aac gtg
act gtg gcc ttc tca 799Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val
Thr Val Ala Phe Ser 120 125 130gga cgc tat gat atc tcc tgg gac tca
gct tat gac gaa ccc tcc aac 847Gly Arg Tyr Asp Ile Ser Trp Asp Ser
Ala Tyr Asp Glu Pro Ser Asn 135 140 145tac gtg ctg agg ggc aag cta
caa tat gag ctg cag tat cgg aac ctc 895Tyr Val Leu Arg Gly Lys Leu
Gln Tyr Glu Leu Gln Tyr Arg Asn Leu 150 155 160aga gac ccc tat gct
gtg agg ccg gtg acc aag ctg atc tca gtg gac 943Arg Asp Pro Tyr Ala
Val Arg Pro Val Thr Lys Leu Ile Ser Val Asp 165 170 175tca aga aac
gtc tct ctt ctc cct gaa gag ttc cac aaa gat tct agc 991Ser Arg Asn
Val Ser Leu Leu Pro Glu Glu Phe His Lys Asp Ser Ser180 185 190
195tac cag ctg cag gtg cgg gca gcg cct cag cca ggc act tca ttc agg
1039Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr Ser Phe Arg
200 205 210ggg acc tgg agt gag tgg agt gac ccc gtc atc ttt cag acc
cag gct 1087Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln Thr
Gln Ala 215 220 225ggg gag ccc gag gca ggc tgg gac cct cac atg ctg
ctg ctc ctg gct 1135Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu
Leu Leu Leu Ala 230 235 240gtc ttg atc att gtc ctg gtt ttc atg ggt
ctg aag atc cac ctg cct 1183Val Leu Ile Ile Val Leu Val Phe Met Gly
Leu Lys Ile His Leu Pro 245 250 255tgg agg cta tgg aaa aag ata tgg
gca cca gtg ccc acc cct gag agt 1231Trp Arg Leu Trp Lys Lys Ile Trp
Ala Pro Val Pro Thr Pro Glu Ser260 265 270 275ttc ttc cag ccc ctg
tac agg gag cac agc ggg aac ttc aag aaa tgg 1279Phe Phe Gln Pro Leu
Tyr Arg Glu His Ser Gly Asn Phe Lys Lys Trp 280 285 290gtt aat acc
cct ttc acg gcc tcc agc ata gag ttg gtg cca cag agt 1327Val Asn Thr
Pro Phe Thr Ala Ser Ser Ile Glu Leu Val Pro Gln Ser 295 300 305tcc
aca aca aca tca gcc tta cat ctg tca ttg tat cca gcc aag gag 1375Ser
Thr Thr Thr Ser Ala Leu His Leu Ser Leu Tyr Pro Ala Lys Glu 310 315
320aag aag ttc ccg ggg ctg ccg ggt ctg gaa gag caa ctg gag tgt gat
1423Lys Lys Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu Glu Cys Asp
325 330 335gga atg tct gag cct ggt cac tgg tgc ata atc ccc ttg gca
gct ggc 1471Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu Ala
Ala Gly340 345 350 355caa gcg gtc tca gcc tac agt gag gag aga gac
cgg cca tat ggt ctg 1519Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp
Arg Pro Tyr Gly Leu 360 365 370gtg tcc att gac aca gtg act gtg gga
gat gca gag ggc ctg tgt gtc 1567Val Ser Ile Asp Thr Val Thr Val Gly
Asp Ala Glu Gly Leu Cys Val 375 380 385tgg ccc tgt agc tgt gag gat
gat ggc tat cca gcc atg aac ctg gat 1615Trp Pro Cys Ser Cys Glu Asp
Asp Gly Tyr Pro Ala Met Asn Leu Asp 390 395 400gct ggc cga gag tct
ggc cct aat tca gag gat ctg ctc ttg gtc aca 1663Ala Gly Arg Glu Ser
Gly Pro Asn Ser Glu Asp Leu Leu Leu Val Thr 405 410 415gac cct gct
ttt ctg tct tgc ggc tgt gtc tca ggt agt ggt ctc agg 1711Asp Pro Ala
Phe Leu Ser Cys Gly Cys Val Ser Gly Ser Gly Leu Arg420 425 430
435ctt gga ggc tcc cca ggc agc cta ctg gac agg ttg agg ctg tca ttt
1759Leu Gly Gly Ser Pro Gly Ser Leu Leu Asp Arg Leu Arg Leu Ser Phe
440 445 450gca aag gaa ggg gac tgg aca gca gac cca acc tgg aga act
ggg tcc 1807Ala Lys Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg Thr
Gly Ser 455 460 465cca gga ggg ggc tct gag agt gaa gca ggt tcc ccc
cct ggt ctg gac 1855Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro
Pro Gly Leu Asp 470 475 480atg gac aca ttt gac agt ggc ttt gca ggt
tca gac tgt ggc
agc ccc 1903Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys Gly
Ser Pro 485 490 495gtg gag act gat gaa gga ccc cct cga agc tat ctc
cgc cag tgg gtg 1951Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr Leu
Arg Gln Trp Val500 505 510 515gtc agg acc cct cca cct gtg gac agt
gga gcc cag agc agc 1993Val Arg Thr Pro Pro Pro Val Asp Ser Gly Ala
Gln Ser Ser 520 525tagcatataa taaccagcta tagtgagaag aggcctctga
gcctggcatt tacagtgtga 2053acatgtaggg gtgtgtgtgt gtgtgtgtgt
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 2113gtgtgtgtgt cttgggttgt
gtgttagcac atccatgttg ggatttggtc tgttgctatg 2173tattgtaatg
ctaaattctc tacccaaagt tctaggccta cgagtgaatt ctcatgttta
2233caaacttgct gtgtaaacct tgttccttaa tttaatacca ttggttaaat
aaaattggct 2293gcaaccaatt actggaggga ttagaggtag ggggcttttg
agttacctgt ttggagatgg 2353agaaggagag aggagagacc aagaggagaa
ggaggaagga gaggagagga gaggagagga 2413gaggagagga gaggagagga
gaggagagga gaggagaggc tgccgtgagg ggagagggac 2473catgagcctg
tggccaggag aaacagcaag tatctggggt acactggtga ggaggtggcc
2533aggccagcag ttagaagagt agattagggg tgacctccag tatttgtcaa
agccaattaa 2593aataacaaaa aaaaaaaaaa agcggccgct ctaga
26284529PRTMus musculus 4Met Pro Arg Gly Pro Val Ala Ala Leu Leu
Leu Leu Ile Leu His Gly1 5 10 15Ala Trp Ser Cys Leu Asp Leu Thr Cys
Tyr Thr Asp Tyr Leu Trp Thr 20 25 30Ile Thr Cys Val Leu Glu Thr Arg
Ser Pro Asn Pro Ser Ile Leu Ser 35 40 45Leu Thr Trp Gln Asp Glu Tyr
Glu Glu Leu Gln Asp Gln Glu Thr Phe 50 55 60Cys Ser Leu His Arg Ser
Gly His Asn Thr Thr His Ile Trp Tyr Thr65 70 75 80Cys His Met Arg
Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val 85 90 95Asn Val Thr
Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe 100 105 110Val
Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val 115 120
125Ala Phe Ser Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu
130 135 140Pro Ser Asn Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu
Gln Tyr145 150 155 160Arg Asn Leu Arg Asp Pro Tyr Ala Val Arg Pro
Val Thr Lys Leu Ile 165 170 175Ser Val Asp Ser Arg Asn Val Ser Leu
Leu Pro Glu Glu Phe His Lys 180 185 190Asp Ser Ser Tyr Gln Leu Gln
Val Arg Ala Ala Pro Gln Pro Gly Thr 195 200 205Ser Phe Arg Gly Thr
Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 210 215 220Thr Gln Ala
Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu Leu225 230 235
240Leu Leu Ala Val Leu Ile Ile Val Leu Val Phe Met Gly Leu Lys Ile
245 250 255His Leu Pro Trp Arg Leu Trp Lys Lys Ile Trp Ala Pro Val
Pro Thr 260 265 270Pro Glu Ser Phe Phe Gln Pro Leu Tyr Arg Glu His
Ser Gly Asn Phe 275 280 285Lys Lys Trp Val Asn Thr Pro Phe Thr Ala
Ser Ser Ile Glu Leu Val 290 295 300Pro Gln Ser Ser Thr Thr Thr Ser
Ala Leu His Leu Ser Leu Tyr Pro305 310 315 320Ala Lys Glu Lys Lys
Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu 325 330 335Glu Cys Asp
Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu 340 345 350Ala
Ala Gly Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 355 360
365Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Gly Asp Ala Glu Gly
370 375 380Leu Cys Val Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro
Ala Met385 390 395 400Asn Leu Asp Ala Gly Arg Glu Ser Gly Pro Asn
Ser Glu Asp Leu Leu 405 410 415Leu Val Thr Asp Pro Ala Phe Leu Ser
Cys Gly Cys Val Ser Gly Ser 420 425 430Gly Leu Arg Leu Gly Gly Ser
Pro Gly Ser Leu Leu Asp Arg Leu Arg 435 440 445Leu Ser Phe Ala Lys
Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg 450 455 460Thr Gly Ser
Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro Pro465 470 475
480Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys
485 490 495Gly Ser Pro Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr
Leu Arg 500 505 510Gln Trp Val Val Arg Thr Pro Pro Pro Val Asp Ser
Gly Ala Gln Ser 515 520 525Ser 5354DNAHomo sapiens 5caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagt 3546118PRTHomo sapiens 6Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser
1157354DNAHomo sapiens 7caggtgcagc tgcaggagtc tggccctggc ctggtgaagc
cttccgagac cctgtctctg 60acctgtgccg tgtccggcta ctccatctcc tccggctact
actggggctg gatcagacag 120cctcctggca agggcctgga gtggatcggc
tccatctctc acaccggcaa cacctactac 180aacccccctc tgaagtccag
agtgaccatc tccgtggaca cctccaagaa ccagttctcc 240ctgaagctgt
cctctgtgac cgctgccgat accgccgtgt actactgtgc cagaggcggc
300ggaatctcca gacctgagta ctggggccag ggcaccctgg tgaccgtgtc ctct
3548118PRTHomo sapiens 8Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
Val Lys Pro Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly
Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly
Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser
Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly
Gly Ile Ser Arg Pro Glu Tyr Trp Gly Gln Gly Thr 100 105 110Leu Val
Thr Val Ser Ser 1159327DNAHomo sapiens 9tcttctgagc tgactcagga
ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct
cagaacctat tatgcaagct ggtaccagca gaagtcagga 120caggccccta
tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc
180ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc
tcaggcggaa 240gacgaggctg actattactg taactcccgg gactccagtg
gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32710109PRTHomo sapiens 10Ser Ser Glu Leu Thr Gln Asp Pro Pro Val
Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly Asp
Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly
Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro Ser
Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala
Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp
Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 85 90 95His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 10511327DNAHomo sapiens
11tcctctgagc tgacccagga tcctgctgtg tctgtggccc tgggccagac cgtcaggatc
60acctgccagg gcgatagcct gagaacctac tacgcctcct ggtatcagca gaagcctgga
120caggcccctg tgctggtgat ctacggcaag cacaagaggc catccggcat
ccctgacaga 180ttctccggct cctcctctgg caataccgcc tccctgacca
tcaccggcgc tcaggccgag 240gacgaggccg actactactg taactcccgg
gactcttccg gcaaccctca cgtgctgttt 300ggcggcggaa cccagctgac cgtgcta
32712109PRTHomo sapiens 12Ser Ser Glu Leu Thr Gln Asp Pro Ala Val
Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly Asp
Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro Ser
Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp
Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 85 90 95His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 10513354DNAartificialH3
VH 13caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgattcatg 300gggttcggcc
gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt
35414118PRTartificialH3 VH 14Gln Val Gln Leu Gln Glu Ser Gly Pro
Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala Val
Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile Arg
Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser His
Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val Thr
Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys Leu
Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg
Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser 11515354DNAartificialH4 VH 15caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgatggctc 300gggttcggcc gcccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagt 35416118PRTartificialH4 VH
16Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1
5 10 15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser
Gly 20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
Glu Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn
Pro Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
Asn Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Trp Leu Gly Phe Gly Arg Pro
Glu Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser
11517354DNAartificialH5 VH 17caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgattcttg 300ggcttcggcc ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagt 35418118PRTartificialH5 VH 18Gln Val Gln Leu Gln
Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu
Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp
Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly
Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75
80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Phe Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly
Thr 100 105 110Leu Val Thr Val Ser Ser 11519354DNAartificialH6 VH
19caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc
60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgattcttc 300ggcttcggcc gcccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagt 35420118PRTartificialH6 VH
20Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1
5 10 15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser
Gly 20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
Glu Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn
Pro Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
Asn Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Phe Phe Gly Phe Gly Arg Pro
Glu Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser
11521327DNAartificialL1 VL 21tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgcgtcccgg tcggtgagcg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta 32722109PRTartificialL1
VL 22Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly
Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr
Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu
Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg
Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr
Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Ala Ser
Arg Ser Val Ser Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr
Gln Leu Thr Val Leu 100 10523327DNAartificialL2 VL 23tcttctgagc
tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag
gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga
120caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat
cccagaccgc 180ttctctggct ccacctcagg agacacagct tccttgacca
tcactggggc tcaggcggaa 240gacgaggctg actattactg tgtcgcccgg
tcggtggtgg gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32724109PRTartificialL2 VL 24Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr
Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro 85 90 95His Val Leu Phe
Gly Gly Gly Thr Gln Leu Thr Val Leu 100 10525327DNAartificialL3 VL
25tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc
60acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga
120caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat
cccagaccgc 180ttctctggct ccacctcagg agacacagct tccttgacca
tcactggggc tcaggcggaa 240gacgaggctg actattactg tgtcagcagg
gcggtggtgg gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32726109PRTartificialL3 VL 26Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ser Arg Ala Val Val Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10527327DNAArtificialL4 VL 27tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tagcacccgc agcagcaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta 32728109PRTartificialL4
VL 28Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly
Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr
Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu
Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg
Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr
Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Ser Thr
Arg Ser Ser Lys Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr
Gln Leu Thr Val Leu 100 10529327DNAartificialL5 VL 29tcttctgagc
tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag
gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga
120caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat
cccagaccgc 180ttctctggct ccacctcagg agacacagct tccttgacca
tcactggggc tcaggcggaa 240gacgaggctg actattactg tgccagcagg
tcctccaagg gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32730109PRTartificialL5 VL 30Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ala Ser Arg Ser Ser Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10531327DNAartificialL6 VL 31tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tatgagcagg agcatctggg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta 32732109PRTartificialL6
VL 32Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly
Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr
Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu
Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg
Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr
Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Met Ser
Arg Ser Ile Trp Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr
Gln Leu Thr Val Leu 100 10533327DNAartificialL8 VL 33tcttctgagc
tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag
gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga
120caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat
cccagaccgc 180ttctctggct ccacctcagg agacacagct tccttgacca
tcactggggc tcaggcggaa 240gacgaggctg actattactg taccacgcgc
tccacccagg gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32734109PRTartificialL8 VL 34Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Thr Thr Arg Ser Thr Gln Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10535327DNAartificialL9 VL 35tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgtcgccagg tccaacaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta 32736109PRTartificialL9
VL 36Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly
Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr
Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu
Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg
Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr
Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Val Ala
Arg Ser Asn Lys Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr
Gln Leu Thr Val Leu 100 10537327DNAartificialL10 VL 37tcttctgagc
tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag
gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga
120caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat
cccagaccgc 180ttctctggct ccacctcagg agacacagct tccttgacca
tcactggggc tcaggcggaa 240gacgaggctg actattactg tatcagccgg
tcgatctacg gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32738109PRTartificialL10 VL 38Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ile Ser Arg Ser Ile Tyr Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10539327DNAartificialL11 VL 39tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg ttcctcccgc tcccgccacg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32740109PRTartificialL11 VL 40Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ser Ser Arg Ser Arg His Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10541327DNAartificialL12 VL 41tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgtcgcgagg gggacgaggg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32742109PRTartificialL12 VL 42Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ala Arg Gly Thr Arg Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10543327DNAartificialL13 VL 43tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgtcacccgc aaccgctacg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32744109PRTartificialL13 VL 44Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Thr Arg Asn Arg Tyr Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10545327DNAartificialL14 VL 45tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tatggcgagg tcgaggaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32746109PRTartificialL14 VL 46Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Met Ala Arg Ser Arg Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10547327DNAartificialL15 VL 47tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg ttccacccgc gccatccacg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32748109PRTartificialL15 VL 48Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ser Thr Arg Ala Ile His Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10549327DNAartificialL16 VL 49tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgtgacgagg agcgcgaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32750109PRTartificialL16 VL 50Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10551327DNAartificialL17 VL 51tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tagcacgagg tcgaggaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32752109PRTartificialL17 VL 52Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ser Thr Arg Ser Arg Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10553327DNAartificialL18 VL 53tcttctgagc tgactcagga ccctcctgtg
tctgtggcct
tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat tatgcaagct
ggtaccagca gaagtcagga 120caggccccta tacttctcct ctatggtaaa
cacaaacggc cctcagggat cccagaccgc 180ttctctggct ccacctcagg
agacacagct tccttgacca tcactggggc tcaggcggaa 240gacgaggctg
actattactg tgtcacgagg agcgtgaagg gcaaccccca tgttctgttc
300ggcggaggga cccagctcac cgtttta 32754109PRTartificialL18 VL 54Ser
Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln1 5 10
15Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala
20 25 30Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu
Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
Gly Ser 50 55 60Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala
Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser
Val Lys Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu
Thr Val Leu 100 10555327DNAartificialL19 VL 55tcttctgagc tgactcagga
ccctcctgtg tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct
cagaacctat tatgcaagct ggtaccagca gaagtcagga 120caggccccta
tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc
180ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc
tcaggcggaa 240gacgaggctg actattactg tgtcgcgcgg gcggtgaggg
gcaaccccca tgttctgttc 300ggcggaggga cccagctcac cgtttta
32756109PRTartificialL19 VL 56Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ala Arg Ala Val Arg Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10557327DNAartificialL20 VL 57tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgtctcccgc agcgcgaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32758109PRTartificialL20 VL 58Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10559327DNAartificialL21 VL 59tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tgccacccgg gcggtccggg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32760109PRTartificialL21 VL 60Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ala Thr Arg Ala Val Arg Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10561327DNAartificialL23 VL 61tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg ttcggcgcgg tcggtgaggg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32762109PRTartificialL23 VL 62Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ser Ala Arg Ser Val Arg Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10563327DNAartificialL24 VL 63tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tatcgccagg agcaacaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32764109PRTartificialL24 VL 64Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Ile Ala Arg Ser Asn Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
10565327DNAartificialL25 VL 65tcttctgagc tgactcagga ccctcctgtg
tctgtggcct tgggacagac agtcacgctc 60acatgccaag gagacagcct cagaacctat
tatgcaagct ggtaccagca gaagtcagga 120caggccccta tacttctcct
ctatggtaaa cacaaacggc cctcagggat cccagaccgc 180ttctctggct
ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa
240gacgaggctg actattactg tacgacgcgg agcaacaagg gcaaccccca
tgttctgttc 300ggcggaggga cccagctcac cgtttta
32766109PRTartificialL25 VL 66Ser Ser Glu Leu Thr Gln Asp Pro Pro
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Thr Leu Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Ser
Gly Gln Ala Pro Ile Leu Leu Leu Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Thr Ser Gly Asp Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105671401DNAartificialVH4 heavy chain 67atgggatgga gctgtatcat
cctcttcttg gtagcaacag ctacaggcgc gcactctcag 60gtgcagctgc aggagtctgg
ccctggcctg gtgaagcctt ccgagaccct gtctctgacc 120tgtgccgtgt
ccggctactc catctcctcc ggctactact ggggctggat cagacagcct
180cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac
ctactacaac 240ccccctctga agtccagagt gaccatctcc gtggacacct
ccaagaacca gttctccctg 300aagctgtcct ctgtgaccgc tgccgatacc
gccgtgtact actgtgccag atggctcggg 360ttcggccgcc cggagtactg
gggcaaaggc accctggtga ccgtgtcctc tgcctccacc 420aagggcccat
cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg
480gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc
gtggaactca 540ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc
tacagtcctc aggactctac 600tccctcagca gcgtggtgac cgtgccctcc
agcagcttgg gcacccagac ctacatctgc 660aacgtgaatc acaagcccag
caacaccaag gtggacaaga aagttgagcc caaatcttgt 720gacaaaactc
acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc
780ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc
tgaggtcaca 840tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca
agttcaactg gtacgtggac 900ggcgtggagg tgcataatgc caagacaaag
ccgcgggagg agcagtacaa cagcacgtac 960cgtgtggtca gcgtcctcac
cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1020tgcaaggtct
ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa
1080ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga
gatgaccaag 1140aaccaggtca gcctgacctg cctggtcaaa ggcttctatc
ccagcgacat cgccgtggag 1200tgggagagca atgggcagcc ggagaacaac
tacaagacca cgcctcccgt gctggactcc 1260gacggctcct tcttcctcta
tagcaagctc accgtggaca agagcaggtg gcagcagggg 1320aacgtcttct
catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1380ctctccctgt ccccgggtaa a 140168467PRTartificialVH4 heavy chain
68Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1
5 10 15Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
Lys 20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr
Ser Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro
Gly Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn
Thr Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr Ile Ser
Val Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser Ser Val
Thr Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg Trp Leu
Gly Phe Gly Arg Pro Glu Tyr Trp Gly 115 120 125Lys Gly Thr Leu Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150 155
160Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
165 170 175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala 180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 245 250 255Ala Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280
285Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
290 295 300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390 395
400Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
405 410 415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val 420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 450 455 460Pro Gly
Lys465691401DNAartificialVH5 heavy chain 69atgggatgga gctgtatcat
cctcttcttg gtagcaacag ctacaggcgc gcactctcag 60gtgcagctgc aggagtctgg
ccctggcctg gtgaagcctt ccgagaccct gtctctgacc 120tgtgccgtgt
ccggctactc catctcctcc ggctactact ggggctggat cagacagcct
180cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac
ctactacaac 240ccccctctga agtccagagt gaccatctcc gtggacacct
ccaagaacca gttctccctg 300aagctgtcct ctgtgaccgc tgccgatacc
gccgtgtact actgtgccag attcttgggc 360ttcggccggc cggagtactg
gggcaaaggc accctggtga ccgtgtcctc tgcctccacc 420aagggcccat
cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg
480gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc
gtggaactca 540ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc
tacagtcctc aggactctac 600tccctcagca gcgtggtgac cgtgccctcc
agcagcttgg gcacccagac ctacatctgc 660aacgtgaatc acaagcccag
caacaccaag gtggacaaga aagttgagcc caaatcttgt 720gacaaaactc
acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc
780ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc
tgaggtcaca 840tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca
agttcaactg gtacgtggac 900ggcgtggagg tgcataatgc caagacaaag
ccgcgggagg agcagtacaa cagcacgtac 960cgtgtggtca gcgtcctcac
cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1020tgcaaggtct
ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa
1080ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga
gatgaccaag 1140aaccaggtca gcctgacctg cctggtcaaa ggcttctatc
ccagcgacat cgccgtggag 1200tgggagagca atgggcagcc ggagaacaac
tacaagacca cgcctcccgt gctggactcc 1260gacggctcct tcttcctcta
tagcaagctc accgtggaca agagcaggtg gcagcagggg 1320aacgtcttct
catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc
1380ctctccctgt ccccgggtaa a 140170467PRTartificialVH5 heavy chain
70Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1
5 10 15Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
Lys 20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr
Ser Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro
Gly Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn
Thr Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr Ile Ser
Val Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser Ser Val
Thr Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg Phe Leu
Gly Phe Gly Arg Pro Glu Tyr Trp Gly 115 120 125Lys Gly Thr Leu Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150 155
160Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
165 170 175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala 180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 245 250 255Ala Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280
285Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
290 295 300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr
Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390 395 400Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 405 410
415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser 450 455 460Pro Gly Lys465711401DNAartificialVH6
heavy chain 71atgggatgga gctgtatcat cctcttcttg gtagcaacag
ctacaggcgc gcactctcag 60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt
ccgagaccct gtctctgacc 120tgtgccgtgt ccggctactc catctcctcc
ggctactact ggggctggat cagacagcct 180cctggcaagg gcctggagtg
gatcggctcc atctctcaca ccggcaacac ctactacaac 240ccccctctga
agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg
300aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag
attcttcggc 360ttcggccgcc cggagtactg gggcaaaggc accctggtga
ccgtgtcctc tgcctccacc 420aagggcccat cggtcttccc cctggcaccc
tcctccaaga gcacctctgg gggcacagcg 480gccctgggct gcctggtcaa
ggactacttc cccgaaccgg tgacggtgtc gtggaactca 540ggcgccctga
ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac
600tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac
ctacatctgc 660aacgtgaatc acaagcccag caacaccaag gtggacaaga
aagttgagcc caaatcttgt 720gacaaaactc acacatgccc accgtgccca
gcacctgaag ccgcgggggc accgtcagtc 780ttcctcttcc ccccaaaacc
caaggacacc ctcatgatct cccggacccc tgaggtcaca 840tgcgtggtgg
tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
900ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 960cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 1020tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1080ggtcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggagga gatgaccaag 1140aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
1200tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gctggactcc 1260gacggctcct tcttcctcta tagcaagctc accgtggaca
agagcaggtg gcagcagggg 1320aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 1380ctctccctgt ccccgggtaa a
140172467PRTartificialVH6 heavy chain 72Met Gly Trp Ser Cys Ile Ile
Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10 15Ala His Ser Gln Val Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30Pro Ser Glu Thr Leu
Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 35 40 45Ser Ser Gly Tyr
Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 50 55 60Leu Glu Trp
Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn65 70 75 80Pro
Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 85 90
95Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
100 105 110Tyr Tyr Cys Ala Arg Phe Phe Gly Phe Gly Arg Pro Glu Tyr
Trp Gly 115 120 125Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
Lys Gly Pro Ser 130 135 140Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
Thr Ser Gly Gly Thr Ala145 150 155 160Ala Leu Gly Cys Leu Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val 165 170 175Ser Trp Asn Ser Gly
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 180 185 190Val Leu Gln
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 195 200 205Pro
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 210 215
220Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
Cys225 230 235 240Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu Ala Ala Gly 245 250 255Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met 260 265 270Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val Asp Val Ser His 275 280 285Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val 290 295 300His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr305 310 315 320Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 325 330
335Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
340 345 350Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val 355 360 365Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
Asn Gln Val Ser 370 375 380Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu385 390 395 400Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro 405 410 415Val Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 420 425 430Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 435 440 445His
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 450 455
460Pro Gly Lys46573702DNAartificialVL3 light chain 73atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtgt
cagcagggcg gtggtgggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70274234PRTartificialVL3 light
chain 74Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Val Ser Arg Ala Val Val 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 23075702DNAartificialVL11 light chain 75atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgttc
ctcccgctcc cgccacggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70276234PRTartificialVL11 light
chain 76Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ser Ser Arg Ser Arg His 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 23077702DNAartificialVL13 light chain 77atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtgt
cacccgcaac cgctacggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70278234PRTartificialVL13 light
chain 78Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Val Thr Arg Asn Arg Tyr 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 23079702DNAartificialVL14 light chain 79atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtat
ggcgaggtcg aggaagggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70280234PRTartificialVL14 light
chain 80Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Met Ala Arg Ser Arg Lys 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 23081702DNAartificialVL17 light chain 81atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccag aatcctgacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtag
cacgaggtcg aggaagggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70282234PRTartificialVL17 light
chain 82Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Arg Ile Leu Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35
40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val
Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp
Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr
Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser
Thr Arg Ser Arg Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly Gly
Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala Pro
Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln Ala
Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe Tyr
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 23083702DNAartificialVL23 light chain 83atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgttc
ggcgcggtcg gtgaggggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70284234PRTartificialVL23 light
chain 84Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ser Ala Arg Ser Val Arg 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 23085702DNAartificialVL24 light chain 85atgggatgga
gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga
cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtat
cgccaggagc aacaagggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70286234PRTartificialVL24 light
chain 86Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr
Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser
Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly
Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala
Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ile Ala Arg Ser Asn Lys 100 105 110Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155
160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr
His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu
Cys Ser225 230871401DNAartificialVHPTM heavy chain with signal
sequence 87atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactctcag 60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct
gtctctgacc 120tgtgccgtgt ccggctactc catctcctcc ggctactact
ggggctggat cagacagcct 180cctggcaagg gcctggagtg gatcggctcc
atctctcaca ccggcaacac ctactacaac 240ccccctctga agtccagagt
gaccatctcc gtggacacct ccaagaacca gttctccctg 300aagctgtcct
ctgtgaccgc tgccgatacc gccgtgtact actgtgccag aggcggcgga
360atctccagac ctgagtactg gggccagggc accctggtga ccgtgtcctc
tgcctccacc 420aagggcccat cggtcttccc cctggcaccc tcctccaaga
gcacctctgg gggcacagcg 480gccctgggct gcctggtcaa ggactacttc
cccgaaccgg tgacggtgtc gtggaactca 540ggcgccctga ccagcggcgt
gcacaccttc ccggctgtcc tacagtcctc aggactctac 600tccctcagca
gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc
660aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc
caaatcttgt 720gacaaaactc acacatgccc accgtgccca gcacctgaag
ccgcgggggc accgtcagtc 780ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 840tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 900ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac
960cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa
ggagtacaag 1020tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga
aaaccatctc caaagccaaa 1080ggtcagcccc gagaaccaca ggtgtacacc
ctgcccccat cccgggagga gatgaccaag 1140aaccaggtca gcctgacctg
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1200tgggagagca
atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc
1260gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg
gcagcagggg 1320aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1380ctctccctgt ccccgggtaa a
140188467PRTartificialVHPTM heavy chain with signal sequence 88Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser
Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly
Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr
Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val
Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg Gly Gly Gly
Ile Ser Arg Pro Glu Tyr Trp Gly 115 120 125Gln Gly Thr Leu Val Thr
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val Phe Pro Leu
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150 155 160Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 165 170
175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu Ala Ala Gly 245 250 255Ala Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280 285Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 290 295
300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390 395 400Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 405 410
415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser 450 455 460Pro Gly Lys465891401DNAartificialVHPDM
heavy chain with signal sequence 89atgggatgga gctgtatcat cctcttcttg
gtagcaacag ctacaggcgc gcactctcag 60gtgcagctgc aggagtctgg ccctggcctg
gtgaagcctt ccgagaccct gtctctgacc 120tgtgccgtgt ccggctactc
catctcctcc ggctactact ggggctggat cagacagcct 180cctggcaagg
gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac
240ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca
gttctccctg 300aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact
actgtgccag aggcggcgga 360atctccagac ctgagtactg gggccagggc
accctggtga ccgtgtcctc tgcctccacc 420aagggcccat cggtcttccc
cctggcaccc tcctccaaga gcacctctgg gggcacagcg 480gccctgggct
gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca
540ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc
aggactctac 600tccctcagca gcgtggtgac cgtgccctcc agcagcttgg
gcacccagac ctacatctgc 660aacgtgaatc acaagcccag caacaccaag
gtggacaaga aagttgagcc caaatcttgt 720gacaaaactc acacatgccc
accgtgccca gcacctgaag ccctgggggc accgtcagtc 780ttcctcttcc
ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca
840tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg
gtacgtggac 900ggcgtggagg tgcataatgc caagacaaag ccgcgggagg
agcagtacaa cagcacgtac 960cgtgtggtca gcgtcctcac cgtcctgcac
caggactggc tgaatggcaa ggagtacaag 1020tgcaaggtct ccaacaaagc
cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1080ggtcagcccc
gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag
1140aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat
cgccgtggag 1200tgggagagca atgggcagcc ggagaacaac tacaagacca
cgcctcccgt gctggactcc 1260gacggctcct tcttcctcta tagcaagctc
accgtggaca agagcaggtg gcagcagggg 1320aacgtcttct catgctccgt
gatgcatgag gctctgcaca accactacac gcagaagagc 1380ctctccctgt
ccccgggtaa a 140190467PRTartificialVHPDM heavy chain with signal
sequence 90Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala
Thr Gly1 5 10 15Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys 20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser
Gly Tyr Ser Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln
Pro Pro Gly Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr
Gly Asn Thr Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr
Ile Ser Val Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser
Ser Val Thr Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg
Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly 115 120 125Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150
155 160Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
Val 165 170 175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
Phe Pro Ala 180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
Ser Val Val Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val
Asp Lys Lys Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly 245 250 255Ala Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265
270Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
275 280 285Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
Glu Val 290 295 300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390
395 400Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro 405 410 415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val 420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
Ser Cys Ser Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser 450 455 460Pro Gly
Lys465911401DNAartificialVH3TM heavy chain with signal sequence
91atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag
60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc
120tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat
cagacagcct 180cctggcaagg gcctggagtg gatcggctcc atctctcaca
ccggcaacac ctactacaac 240ccccctctga agtccagagt gaccatctcc
gtggacacct ccaagaacca gttctccctg 300aagctgtcct ctgtgaccgc
tgccgatacc gccgtgtact actgtgccag attcatgggg 360ttcggccgcc
cggagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc
420aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg
gggcacagcg 480gccctgggct gcctggtcaa ggactacttc cccgaaccgg
tgacggtgtc gtggaactca 540ggcgccctga ccagcggcgt gcacaccttc
ccggctgtcc tacagtcctc aggactctac 600tccctcagca gcgtggtgac
cgtgccctcc agcagcttgg gcacccagac ctacatctgc 660aacgtgaatc
acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt
720gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc
accgtcagtc 780ttcctcttcc ccccaaaacc caaggacacc ctcatgatct
cccggacccc tgaggtcaca 840tgcgtggtgg tggacgtgag ccacgaagac
cctgaggtca agttcaactg gtacgtggac 900ggcgtggagg tgcataatgc
caagacaaag ccgcgggagg agcagtacaa cagcacgtac 960cgtgtggtca
gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
1020tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1080ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggagga gatgaccaag 1140aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1200tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gctggactcc 1260gacggctcct
tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg
1320aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac
gcagaagagc 1380ctctccctgt ccccgggtaa a 140192467PRTartificialVH3DM
heavy chain with signal sequence 92Met Gly Trp Ser Cys Ile Ile Leu
Phe Leu Val Ala Thr Ala Thr Gly1 5 10 15Ala His Ser Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30Pro Ser Glu Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 35 40 45Ser Ser Gly Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 50 55 60Leu Glu Trp Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn65 70 75 80Pro Pro
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 85 90 95Gln
Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 100 105
110Tyr Tyr Cys Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly
115 120 125Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
Pro Ser 130 135 140Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
Gly Gly Thr Ala145 150 155 160Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val Thr Val 165 170 175Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe Pro Ala 180 185 190Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 195 200 205Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 210 215 220Lys
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys225 230
235 240Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu
Gly 245 250 255Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met 260 265 270Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His 275 280 285Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val 290 295 300His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr305 310 315 320Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 325 330 335Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 340 345
350Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
355 360 365Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
Val Ser 370 375 380Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu385 390 395 400Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro 405 410 415Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val 420 425 430Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 435 440 445His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 450 455 460Pro
Gly Lys465931401DNAartificialVH3DM heavy chain with signal sequence
93atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag
60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc
120tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat
cagacagcct 180cctggcaagg gcctggagtg gatcggctcc atctctcaca
ccggcaacac ctactacaac 240ccccctctga agtccagagt gaccatctcc
gtggacacct ccaagaacca gttctccctg 300aagctgtcct ctgtgaccgc
tgccgatacc gccgtgtact actgtgccag attcatgggg 360ttcggccgcc
cggagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc
420aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg
gggcacagcg 480gccctgggct gcctggtcaa ggactacttc cccgaaccgg
tgacggtgtc gtggaactca 540ggcgccctga ccagcggcgt gcacaccttc
ccggctgtcc tacagtcctc aggactctac 600tccctcagca gcgtggtgac
cgtgccctcc agcagcttgg gcacccagac ctacatctgc 660aacgtgaatc
acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt
720gacaaaactc acacatgccc accgtgccca gcacctgaag ccctgggggc
accgtcagtc 780ttcctcttcc ccccaaaacc caaggacacc ctcatgatct
cccggacccc tgaggtcaca 840tgcgtggtgg tggacgtgag ccacgaagac
cctgaggtca agttcaactg gtacgtggac 900ggcgtggagg tgcataatgc
caagacaaag ccgcgggagg agcagtacaa cagcacgtac 960cgtgtggtca
gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag
1020tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc
caaagccaaa 1080ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat
cccgggagga gatgaccaag 1140aaccaggtca gcctgacctg cctggtcaaa
ggcttctatc ccagcgacat cgccgtggag 1200tgggagagca atgggcagcc
ggagaacaac tacaagacca cgcctcccgt gctggactcc 1260gacggctcct
tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg
1320aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac
gcagaagagc 1380ctctccctgt ccccgggtaa a 140194467PRTartificialVH3TM
heavy chain with signal sequence 94Met Gly Trp Ser Cys Ile Ile Leu
Phe Leu Val Ala Thr Ala Thr Gly1 5 10 15Ala His Ser Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30Pro Ser Glu Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 35 40 45Ser Ser Gly Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 50 55 60Leu Glu Trp Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn65 70 75 80Pro Pro
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 85 90 95Gln
Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 100 105
110Tyr Tyr Cys Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly
115 120 125Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
Pro Ser 130 135 140Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
Gly Gly Thr Ala145 150 155 160Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val Thr Val 165 170 175Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe Pro Ala 180 185 190Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 195 200 205Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 210 215 220Lys
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys225 230
235 240Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
Gly 245 250 255Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met 260 265 270Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His 275 280 285Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val 290 295 300His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr305 310 315 320Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 325 330 335Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 340 345
350Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
355 360 365Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
Val Ser 370 375 380Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu385 390 395 400Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro 405 410 415Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val 420 425 430Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 435 440 445His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 450 455 460Pro
Gly Lys46595702DNAartificialVL2 light chain with signal sequence
95atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc
60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc
120tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa
gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac aagaggccat
ccggcatccc tgacagattc 240tccggctcct cctctggcaa taccgcctcc
ctgaccatca ctggggctca ggcggaagac 300gaggctgact attactgtgt
cgcccggtcg gtggtgggca acccccatgt tctgttcggc 360ggagggaccc
agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc
420ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct
cataagtgac 480ttctacccgg gagccgtgac agtggcctgg aaggcagata
gcagccccgt caaggcggga 540gtggagacca ccacaccctc caaacaaagc
aacaacaagt acgcggccag cagctatctg 600agcctgacgc ctgagcagtg
gaagtcccac agaagctaca gctgccaggt cacgcatgaa 660gggagcaccg
tggagaagac agtggcccct acagaatgtt ca 70296234PRTartificialVL2 light
chain with signal sequence 96Met Gly Trp Ser Cys Ile Ile Leu Phe
Leu Val Ala Thr Ala Thr Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr
Gln Asp Pro Ala Val Ser Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile
Thr Cys Gln Gly Asp Ser Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr
Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys
His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala
Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val 100 105
110Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
115 120 125Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
Ser Ser 130 135 140Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys
Leu Ile Ser Asp145 150 155 160Phe Tyr Pro Gly Ala Val Thr Val Ala
Trp Lys Ala Asp Ser Ser Pro 165 170 175Val Lys Ala Gly Val Glu Thr
Thr Thr Pro Ser Lys Gln Ser Asn Asn 180 185 190Lys Tyr Ala Ala Ser
Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 195 200 205Ser His Arg
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 210 215 220Glu
Lys Thr Val Ala Pro Thr Glu Cys Ser225 23097702DNAartificialVL6
light chain with signal sequence 97atgggatgga gctgtatcat cctcttcttg
gtagcaacag ctacaggcgc gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct
gtggccctgg gccagaccgt caggatcacc 120tgccagggcg atagcctgag
aacctactac gcctcctggt atcagcagaa gcctggacag 180gcccctgtgc
tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc
240tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca
ggcggaagac 300gaggctgact attactgtat gagcaggagc atctggggca
acccccatgt tctgttcggc 360ggagggaccc agctcaccgt tttaggtcag
cccaaggctg ccccctcggt cactctgttc 420ccgccctcct ctgaggagct
tcaagccaac aaggccacac tggtgtgtct cataagtgac 480ttctacccgg
gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga
540gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag
cagctatctg 600agcctgacgc ctgagcagtg gaagtcccac agaagctaca
gctgccaggt cacgcatgaa 660gggagcaccg tggagaagac agtggcccct
acagaatgtt ca 70298234PRTartificialVL6 light chain with signal
sequence 98Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala
Thr Gly1 5 10 15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val
Ser Val Ala 20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp
Ser Leu Arg Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser
Gly Ile Pro Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp
Tyr Tyr Cys Met Ser Arg Ser Ile Trp 100 105 110Gly Asn Pro His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150
155 160Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser
Pro 165 170 175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln
Ser Asn Asn 180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr
Pro Glu Gln Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val
Thr His Glu Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr
Glu Cys Ser225 23099702DNAartificialVL9 light chain with signal
sequence 99atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt cgccaggtcc aacaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt ca
702100234PRTartificialVL9 light chain with signal sequence 100Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Ala Arg Ser Asn Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230101702DNAartificialVL16 light chain with signal sequence
101atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt gacgaggagc gcgaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt ca
702102234PRTartificialVL16 light chain with signal sequence 102Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Thr Arg Ser Ala Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230103702DNAartificialVL18 light chain with signal sequence
103atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt cacgaggagc gtgaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt ca
702104234PRTartificialVL18 light chain with signal sequence 104Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Thr Arg Ser Val Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230105702DNAartificialVL20 light chain with signal sequence
105atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt ctcccgcagc gcgaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt ca
702106234PRTartificialVL20 light chain with signal sequence 106Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Ser Arg Ser Ala Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230107702DNAartificialVL25 light chain with signal sequence
107atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtac gacgcggagc aacaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt ca
702108234PRTartificialVL25 light chain with signal sequence 108Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Thr Thr Arg Ser Asn Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230109732DNAartificialH3 scFV 109caggtgcagc tgcaggagtc
gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta
ctccatcagc agtggttact actggggctg gatccggcag 120cccccaggga
aggggttgga gtggattggg agtatctctc atactgggaa cacctactac
180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa
ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac acggccgtgt
attactgtgc gcgattcatg 300gggttcggcc gcccggagta ctggggcaaa
ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg
ctctggcggt ggcggaagtg cactttcttc tgagctgact 420caggaccctc
ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac
480agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc
ccctatactt 540ctcctctatg gtaaacacaa acggccctca gggatcccag
accgcttctc tggctccacc 600tcaggagaca cagcttcctt gaccatcact
ggggctcagg cggaagacga ggctgactat 660tactgtaact cccgggactc
cagtggcaac ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732110244PRTartificialH3 scFV 110Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 210 215 220Arg
Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu111732DNAartificialH4 scFV 111caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgatggctc 300gggttcggcc gcccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtaact
cccgggactc cagtggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732112244PRTartificialH4 scFV 112Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Trp Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser
210 215 220Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu113732DNAartificialH5 scFV
113caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgattcttg 300ggcttcggcc
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732114244PRTartificialH5 scFV 114Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Phe Leu Gly Phe Gly Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180
185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu
Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr
Cys Asn Ser 210 215 220Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe
Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu115732DNAartificialH6 scFv 115caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgattcttc 300ggcttcggcc gcccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtaact cccgggactc cagtggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732116244PRTartificialH6 scFv 116Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Phe Phe Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 210 215 220Arg
Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu117732DNAartificialL1 scFv 117caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtgcgt
cccggtcggt gagcggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732118244PRTartificialL1 scFv 118Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser
210 215 220Arg Ser Val Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu119732DNAartificialL2 scFv
119caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtgtcg cccggtcggt ggtgggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732120244PRTartificialL2 scFv 120Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Val Ala 210 215 220Arg Ser Val Val Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu121732DNAartificialL3 scFV 121caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtgtca gcagggcggt ggtgggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732122244PRTartificialL3 scFv 122Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser 210 215 220Arg
Ala Val Val Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu123732DNAartificialL4 scFv 123caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtagca
cccgcagcag caagggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732124244PRTartificialL4 scFv 124Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr
210 215 220Arg Ser Ser Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu125732DNAartificialL5 scFv
125caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtgcca gcaggtcctc caagggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732126244PRTartificialL5 scFv 126Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ala Ser 210 215 220Arg Ser Ser Lys Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu127732DNAartificialL6 scFv 127caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtatga gcaggagcat ctggggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732128244PRTartificialL6 scFv 128Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly
Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala Val Ser
Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln
Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser His Thr
Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val Thr Ile
Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys Leu Ser
Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly
Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105 110Leu
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120
125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro
130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln
Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln
Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr Gly Lys
His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser Gly Ser
Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly Ala Gln
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ser 210 215 220Arg Ser Ile
Trp Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230 235
240Leu Thr Val Leu129732DNAartificialL8 scFv 129caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtacca
cgcgctccac ccagggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732130244PRTartificialL8 scFv 130Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr
210 215 220Arg Ser Thr Gln Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu131732DNAartificialL9 scFv
131caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtgtcg ccaggtccaa caagggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732132244PRTartificialL9 scFv 132Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Val Ala 210 215 220Arg Ser Asn Lys Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu133732DNAartificialL10 scFv 133caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtatca gccggtcgat ctacggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732134244PRTartificialL10 scFv 134Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ile Ser 210 215 220Arg
Ser Ile Tyr Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu135732DNAartificialL11 scFv 135caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgttcct
cccgctcccg ccacggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732136244PRTartificialL11 scFv 136Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser
210 215 220Arg Ser Arg His Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu137732DNAartificialL12 scFv
137caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtgtcg cgagggggac gaggggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732138244PRTartificialL12 scFv 138Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Val Ala 210 215 220Arg Gly Thr Arg Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu139732DNAartificialL13 scFv 139caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtgtca cccgcaaccg ctacggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732140244PRTartificialL13 scFv 140Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195
200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val
Thr 210 215 220Arg Asn Arg Tyr Gly Asn Pro His Val Leu Phe Gly Gly
Gly Thr Gln225 230 235 240Leu Thr Val Leu141732DNAartificialL14
scFv 141caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtatgg cgaggtcgag gaagggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732142244PRTartificialL14 scFv 142Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Met Ala 210 215 220Arg Ser Arg Lys Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu143732DNAartificialL15 scFv 143caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgttcca cccgcgccat ccacggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732144244PRTartificialL15 scFv 144Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 210 215 220Arg
Ala Ile His Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu145732DNAartificialL16 scFv 145caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtgtga
cgaggagcgc gaagggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732146244PRTartificialL16 scFv 146Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr
210 215 220Arg Ser Ala Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu147732DNAartificialL17 scFv
147caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtagca cgaggtcgag gaagggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732148244PRTartificialL17 scFv 148Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ser Thr 210 215 220Arg Ser Arg Lys Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu149732DNAartificialL18 scFv 149caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtgtca cgaggagcgt gaagggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732150244PRTartificialL18 scFv 150Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr 210 215 220Arg
Ser Val Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu151732DNAartificialL19 scFv 151caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtgtcg
cgcgggcggt gaggggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732152244PRTartificialL19 scFv 152Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala
210 215 220Arg Ala Val Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu153732DNAartificialL20 scFv
153caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgtgtct cccgcagcgc gaagggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732154244PRTartificialL20 scFv 154Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser 210 215 220Arg
Ser Ala Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu155732DNAartificialL21 scFv 155caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtgcca
cccgggcggt ccggggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732156244PRTartificialL21 scFv 156Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr
210 215 220Arg Ala Val Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu157732DNAartificialL23 scFv
157caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac
cctgtccctc 60acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg
gatccggcag 120cccccaggga aggggttgga gtggattggg agtatctctc
atactgggaa cacctactac 180aacccgcccc tcaagagtcg cgtcaccata
tcagtagaca cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac
cgccgcagac acggccgtgt attactgtgc gcgaggtggg 300ggaattagca
ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc
360ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc
tgagctgact 420caggaccctc ctgtgtctgt ggccttggga cagacagtca
cgctcacatg ccaaggagac 480agcctcagaa cctattatgc aagctggtac
cagcagaagt caggacaggc ccctatactt 540ctcctctatg gtaaacacaa
acggccctca gggatcccag accgcttctc tggctccacc 600tcaggagaca
cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat
660tactgttcgg cgcggtcggt gaggggcaac ccccatgttc tgttcggcgg
agggacccag 720ctcaccgttt ta 732158244PRTartificialL23 scFv 158Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10
15Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
Trp 35 40 45Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro
Pro Leu 50 55 60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
Gln Phe Ser65 70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu
Tyr Trp Gly Lys Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala
Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala
Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser
Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170
175Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile
180 185 190Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser
Leu Thr 195 200 205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
Tyr Cys Ser Ala 210 215 220Arg Ser Val Arg Gly Asn Pro His Val Leu
Phe Gly Gly Gly Thr Gln225 230 235 240Leu Thr Val
Leu159732DNAartificialL24 scFv 159caggtgcagc tgcaggagtc gggcccagga
ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg tctctggtta ctccatcagc
agtggttact actggggctg gatccggcag 120cccccaggga aggggttgga
gtggattggg agtatctctc atactgggaa cacctactac 180aacccgcccc
tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc
240ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc
gcgaggtggg 300ggaattagca ggccggagta ctggggcaaa ggcaccctgg
tcaccgtctc gagtggaggc 360ggcggttcag gcggaggtgg ctctggcggt
ggcggaagtg cactttcttc tgagctgact 420caggaccctc ctgtgtctgt
ggccttggga cagacagtca cgctcacatg ccaaggagac 480agcctcagaa
cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt
540ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc
tggctccacc 600tcaggagaca cagcttcctt gaccatcact ggggctcagg
cggaagacga ggctgactat 660tactgtatcg ccaggagcaa caagggcaac
ccccatgttc tgttcggcgg agggacccag 720ctcaccgttt ta
732160244PRTartificialL24 scFv 160Gln Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser Leu Thr Cys Ala
Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly Trp Ile
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser Ile Ser
His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser Arg Val
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75 80Leu Lys
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala
Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 100 105
110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp
Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr
Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr Tyr Ala Ser Trp
Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile Leu Leu Leu Tyr
Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro Asp Arg Phe Ser
Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200 205Ile Thr Gly
Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ile Ala 210 215 220Arg
Ser Asn Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln225 230
235 240Leu Thr Val Leu161732DNAartificialL25 scFv 161caggtgcagc
tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc 60acctgcgctg
tctctggtta ctccatcagc agtggttact actggggctg gatccggcag
120cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa
cacctactac 180aacccgcccc tcaagagtcg cgtcaccata tcagtagaca
cgtccaagaa ccagttctcc 240ctgaaactga gctctgtgac cgccgcagac
acggccgtgt attactgtgc gcgaggtggg 300ggaattagca ggccggagta
ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc 360ggcggttcag
gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact
420caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg
ccaaggagac 480agcctcagaa cctattatgc aagctggtac cagcagaagt
caggacaggc ccctatactt 540ctcctctatg gtaaacacaa acggccctca
gggatcccag accgcttctc tggctccacc 600tcaggagaca cagcttcctt
gaccatcact ggggctcagg cggaagacga ggctgactat 660tactgtacga
cgcggagcaa caagggcaac ccccatgttc tgttcggcgg agggacccag
720ctcaccgttt ta 732162244PRTartificialL25 scFv 162Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu1 5 10 15Thr Leu Ser
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr
Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile
Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55
60Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65
70 75 80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys
Gly Thr 100 105 110Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu
Leu Thr Gln Asp Pro Pro 130 135 140Val Ser Val Ala Leu Gly Gln Thr
Val Thr Leu Thr Cys Gln Gly Asp145 150 155 160Ser Leu Arg Thr Tyr
Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 165 170 175Ala Pro Ile
Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 180 185 190Pro
Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 195 200
205Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr
210 215 220Arg Ser Asn Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly
Thr Gln225 230 235 240Leu Thr Val Leu1636PRTHomo sapiens 163Ser Gly
Tyr Tyr Trp Gly1 516416PRTHomo sapiens 164Ser Ile Ser His Thr Gly
Asn Thr Tyr Tyr Asn Pro Pro Leu Lys Ser1 5 10 151659PRTartificialH3
heavy chain CDR3 165Phe Met Gly Phe Gly Arg Pro Glu Tyr1
51669PRTartificialH4 heavy chain CDR3 166Trp Leu Gly Phe Gly Arg
Pro Glu Tyr1 51679PRTartificialH5 heavy chain CDR3 167Phe Leu Gly
Phe Gly Arg Pro Glu Tyr1 51689PRTartificialH6 heavy chain CDR3
168Phe Phe Gly Phe Gly Arg Pro Glu Tyr1 51699PRTHomo sapiens 169Gly
Gly Gly Ile Ser Arg Pro Glu Tyr1 517012PRTHomo sapiens 170Asn Ser
Arg Asp Ser Ser Gly Asn Pro His Val Leu1 5 1017112PRTartificialL1
light chain CDR3 171Ala Ser Arg Ser Val Ser Gly Asn Pro His Val
Leu1 5 1017212PRTartificialL2 light chain CDR3 172Val Ala Arg Ser
Val Val Gly Asn Pro His Val Leu1 5 1017312PRTartificialL3 light
chain CDR3 173Val Ser Arg Ala Val Val Gly Asn Pro His Val Leu1 5
1017412PRTartificialL4 light chain CDR3 174Ser Thr Arg Ser Ser Lys
Gly Asn Pro His Val Leu1 5 1017512PRTartificialL5 light chain CDR3
175Ala Ser Arg Ser Ser Lys Gly Asn Pro His Val Leu1 5
1017612PRTartificialL6 light chain CDR3 176Met Ser Arg Ser Ile Trp
Gly Asn Pro His Val Leu1 5 1017712PRTartificialL8 light chain CDR3
177Thr Thr Arg Ser Thr Gln Gly Asn Pro His Val Leu1 5
1017812PRTartificialL9 light chain CDR3 178Val Ala Arg Ser Asn Lys
Gly Asn Pro His Val Leu1 5 1017912PRTartificialL10 light chain CDR3
179Ile Ser Arg Ser Ile Tyr Gly Asn Pro His Val Leu1 5
1018012PRTartificialL11 light chain CDR3 180Ser Ser Arg Ser Arg His
Gly Asn Pro His Val Leu1 5 1018112PRTartificialL12 light chain CDR3
181Val Ala Arg Gly Thr Arg Gly Asn Pro His Val Leu1 5
1018212PRTartificialL13 light chain CDR3 182Val Thr Arg Asn Arg Tyr
Gly Asn Pro His Val Leu1 5 1018312PRTartificialL14 light chain CDR3
183Met Ala Arg Ser Arg Lys Gly Asn Pro His Val Leu1 5
1018412PRTartificialL15 light chain CDR3 184Ser Thr Arg Ala Ile His
Gly Asn Pro His Val Leu1 5 1018512PRTartificialL16 light chain CDR3
185Val Thr Arg Ser Ala Lys Gly Asn Pro His Val Leu1 5
1018612PRTartificialL17 light chain CDR3 186Ser Thr Arg Ser Arg Lys
Gly Asn Pro His Val Leu1 5 1018712PRTartificialL18 light chain CDR3
187Val Thr Arg Ser Val Lys Gly Asn Pro His Val Leu1 5
1018812PRTartificialL19 light chain CDR3 188Val Ala Arg Ala Val Arg
Gly Asn Pro His Val Leu1 5 1018912PRTartificialL20 light chain CDR3
189Val Ser Arg Ser Ala Lys Gly Asn Pro His Val Leu1 5
1019012PRTartificialL21 light chain CDR3 190Ala Thr Arg Ala Val Arg
Gly Asn Pro His Val Leu1 5 1019112PRTartificialL23 light chain CDR3
191Ser Ala Arg Ser Val Arg Gly Asn Pro His Val Leu1 5
1019212PRTartificialL24 light chain CDR3 192Ile Ala Arg Ser Asn Lys
Gly Asn Pro His Val Leu1 5 1019312PRTartificialL25 light chain CDR3
193Thr Thr Arg Ser Asn Lys Gly Asn Pro His Val Leu1 5
1019411PRTHomo sapiens 194Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala
Ser1 5 101957PRTHomo sapiens 195Gly Lys His Lys Arg Pro Ser1
5196330PRTartificialhuman IgG constant region TM 196Ala Ser Thr Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys1 5 10 15Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30Phe Pro
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45Gly
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55
60Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr65
70 75 80Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
Lys 85 90 95Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
Pro Cys 100 105 110Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe
Leu Phe Pro Pro 115 120 125Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys 130 135 140Val Val Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn
Trp145 150 155 160Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu 165 170 175Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu 180 185 190His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu225 230 235 240Met
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250
255Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe 275 280 285Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn 290 295 300Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr305 310 315 320Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 325 330197330PRTartificialhuman IgG constant region DM
197Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys1
5 10 15Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
Tyr 20 25 30Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser 35 40 45Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
Leu Tyr Ser 50 55 60Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr65 70 75 80Tyr Ile Cys Asn Val Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys 85 90 95Lys Val Glu Pro Lys Ser Cys Asp Lys
Thr His Thr Cys Pro Pro Cys 100 105 110Pro Ala Pro Glu Ala Leu Gly
Ala Pro Ser Val Phe Leu Phe Pro Pro 115 120 125Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp145 150 155
160Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu 180 185 190His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn 195 200 205Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly 210 215 220Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu225 230 235 240Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280
285Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr305 310 315 320Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325
330198106PRTHomo sapiens 198Gly Gln Pro Lys Ala Ala Pro Ser Val Thr
Leu Phe Pro Pro Ser Ser1 5 10 15Glu Glu Leu Gln Ala Asn Lys Ala Thr
Leu Val Cys Leu Ile Ser Asp 20 25 30Phe Tyr Pro Gly Ala Val Thr Val
Ala Trp Lys Ala Asp Ser Ser Pro 35 40 45Val Lys Ala Gly Val Glu Thr
Thr Thr Pro Ser Lys Gln Ser Asn Asn 50 55 60Lys Tyr Ala Ala Ser Ser
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys65 70 75 80Ser His Arg Ser
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 85 90 95Glu Lys Thr
Val Ala Pro Thr Glu Cys Ser 100 105199100DNAHomo sapiens
199gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg
ggaattagca 60ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc
10020034PRTHomo sapiens 200Ser Ser Val Thr Ala Ala Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Gly1 5 10 15Gly Gly Ile Ser Arg Pro Glu Tyr Trp
Gly Lys Gly Thr Leu Val Thr 20 25 30Val Ser20160DNAartificialH3B1
VH library 201cacataatga cacgcgctnn snnsnnsnns nnsnnsggcc
tcatgacccc gtttccgtgg 6020220PRTartificialH3B1 VH library 202Val
Tyr Tyr Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp1 5 10
15Gly Lys Gly Thr 2020356DNAartificialH3B2 VH library 203gacacgcgct
ccaccccctn nsnnsnnsnn snnsnnsacc ccgtttccgt gggacc
5620418PRTartificialH3B2 VH library 204Cys Ala Arg Gly Gly Gly Ile
Ser Arg Pro Glu Tyr Trp Gly Lys Gly1 5 10 15Thr Leu20585DNAHomo
sapiens 205ggctgactat tactgtaact cccgggactc cagtggcaac ccccatgttc
tgttcggcgg 60agggacccag ctcaccgttt taagt 8520628PRTHomo sapiens
206Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro His Val1
5 10 15Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser 20
2520755DNAartificialL3B1 VL library 207ccgactgata atgacannsn
nsnnsnnsnn snnsccgttg ggggtacaag acaag 5520818PRTartificialL3B1 VL
library 208Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro
His Val1 5 10 15Leu Phe20959DNAartificialL3B2 VL library
209gacattgagg gccctgaggt cannsnnsnn snnsnnsnns aagccgcctc cctgggtcg
5921019PRTartificialL3B2 VL library 210Cys Asn Ser Arg Asp Ser Ser
Gly Asn Pro His Val Leu Phe Gly Gly1 5 10 15Gly Thr
Gln211617DNAHomo sapiensCDS(47)..(532) 211gctgaagtga aaacgagacc
aaggtctagc tctactgttg gtactt atg aga tcc 55 Met Arg Ser 1agt cct
ggc aac atg gag agg att gtc atc tgt ctg atg gtc atc ttc 103Ser Pro
Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe 5 10 15ttg
ggg aca ctg gtc cac aaa tca agc tcc caa ggt caa gat cgc cac 151Leu
Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His20 25 30
35atg att aga atg cgt caa ctt ata gat att gtt gat cag ctg aaa aat
199Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn
40 45 50tat gtg aat gac ttg gtc cct gaa ttt ctg cca gct cca gaa gat
gta 247Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp
Val 55 60 65gag aca aac tgt gag tgg tca gct ttt tcc tgc ttt cag aag
gcc caa 295Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys
Ala Gln 70 75 80cta aag tca gca aat aca gga aac aat gaa agg ata atc
aat gta tca 343Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile
Asn Val Ser 85 90 95att aaa aag ctg aag agg aaa cca cct tcc aca aat
gca ggg aga aga 391Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn
Ala Gly Arg Arg100 105 110 115cag aaa cac aga cta aca tgc cct tca
tgt gat tct tat gag aaa aaa 439Gln Lys His Arg Leu Thr Cys Pro Ser
Cys Asp Ser Tyr Glu Lys Lys 120 125 130cca ccc aaa gaa ttc cta gaa
aga ttc aaa tca ctt ctc caa aag atg 487Pro Pro Lys Glu Phe Leu Glu
Arg Phe Lys Ser Leu Leu Gln Lys Met 135 140 145att cat cag cat ctg
tcc tct aga aca cac gga agt gaa gat tcc 532Ile His Gln His Leu Ser
Ser Arg Thr His Gly Ser Glu Asp Ser 150 155 160tgaggatcta
acttgcagtt ggacactatg ttacatactc taatatagta gtgaaagtca
592tttctttgta ttccaagtgg aggag 617212162PRTHomo sapiens 212Met Arg
Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met1 5 10 15Val
Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 20 25
30Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln
35 40 45Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala
Pro 50 55 60Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys
Phe Gln65 70 75 80Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn
Glu Arg Ile Ile 85 90 95Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro
Pro Ser Thr Asn Ala 100 105 110Gly Arg Arg Gln Lys His Arg Leu Thr
Cys Pro Ser Cys Asp Ser Tyr 115 120 125Glu Lys Lys Pro Pro Lys Glu
Phe Leu Glu Arg Phe Lys Ser Leu Leu 130 135 140Gln Lys Met Ile His
Gln His Leu Ser Ser Arg Thr His Gly Ser Glu145 150 155 160Asp
Ser213448PRTartificialVH3DM heavy chain 213Gln Val Gln Leu Gln Glu
Ser Gly Pro Gly Leu Val Lys Pro Ser Glu1 5 10 15Thr Leu Ser Leu Thr
Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser
Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75
80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Gln Gly
Thr 100 105 110Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
Val Phe Pro 115 120 125Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly 130 135 140Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val Thr Val Ser Trp Asn145 150 155 160Ser Gly Ala Leu Thr Ser
Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200
205Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
210 215 220His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala
Pro Ser225 230 235 240Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg 245 250 255Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro 260 265 270Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala 275 280 285Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr305 310 315
320Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
325 330 335Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu 340 345 350Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys 355 360 365Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser 370 375 380Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp385 390 395 400Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440
445214215PRTartificialVL2 light chain 214Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215215109PRTartificialvariable
region of VL2 light chain 215Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105216215PRTartificialVL18 light chain 216Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215217109PRTartificialvariable
region of VL18 light chain 217Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105218448PRTartificialVH3TM heavy chain 218Gln Val Gln Leu Gln Glu
Ser Gly Pro Gly Leu Val Lys Pro Ser Glu1 5 10 15Thr Leu Ser Leu Thr
Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser
Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75
80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Gln Gly
Thr 100 105 110Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
Val Phe Pro 115 120 125Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly 130 135 140Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val Thr Val Ser Trp Asn145 150 155 160Ser Gly Ala Leu Thr Ser
Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200
205Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
210 215 220His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala
Pro Ser225 230 235 240Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg 245 250 255Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro 260 265 270Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala 275 280 285Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr305 310 315
320Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
325 330 335Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu 340 345 350Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys 355 360 365Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser 370 375 380Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp385 390 395 400Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440
445219448PRTartificialVHPTM heavy chain 219Gln Val Gln Leu Gln Glu
Ser Gly Pro Gly Leu Val Lys Pro Ser Glu1 5 10 15Thr Leu Ser Leu Thr
Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30Tyr Tyr Trp Gly
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45Ile Gly Ser
Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 50 55 60Lys Ser
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser65 70 75
80Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Gln Gly
Thr 100 105 110Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
Val Phe Pro 115 120 125Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly 130 135 140Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val Thr Val Ser Trp Asn145 150 155 160Ser Gly Ala Leu Thr Ser
Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200
205Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
210 215 220His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala
Pro Ser225 230 235 240Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg 245 250 255Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp Pro 260 265 270Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn Ala 275 280 285Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr305 310 315
320Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
325 330 335Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu 340 345 350Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys 355 360 365Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser 370 375 380Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp385 390 395 400Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440
445220215PRTartificialVL6 light chain 220Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215221109PRTartificialvariable
region of VL6 light chain 221Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105222215PRTartificialVL9 light chain 222Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215223109PRTartificialvariable
region of VL9 light chain 223Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105224215PRTartificialVL16 light chain 224Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215225109PRTartificialvariable
region of VL16 light chain 225Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105226215PRTartificialVL20 light chain 226Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195 200
205Val Ala Pro Thr Glu Cys Ser 210 215227109PRTartificialvariable
region of VL20 light chain 227Ser Ser Glu Leu Thr Gln Asp Pro Ala
Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr Cys Gln Gly
Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His Lys Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser Gly Asn Thr
Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75 80Asp Glu Ala
Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro 85 90 95His Val
Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100
105228215PRTartificialVL25 light chain 228Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys His
Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys Gly Asn Pro
85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln
Pro 100 105 110Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
Glu Glu Leu 115 120 125Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
Ser Asp Phe Tyr Pro 130 135 140Gly Ala Val Thr Val Ala Trp Lys Ala
Asp Ser Ser Pro Val Lys Ala145 150 155 160Gly Val Glu Thr Thr Thr
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 165 170 175Ala Ser Ser Tyr
Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 180 185 190Ser Tyr
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 195
200 205Val Ala Pro Thr Glu Cys Ser 210
215229109PRTartificialvariable region of VL25 light chain 229Ser
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10
15Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala
20 25 30Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile
Tyr 35 40 45Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
Gly Ser 50 55 60Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala
Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser
Asn Lys Gly Asn Pro 85 90 95His Val Leu Phe Gly Gly Gly Thr Gln Leu
Thr Val Leu 100 10523034DNAArtificial SequencePrimer BssHII_II_VH_F
230gcttggcgcg cactctcagg tgcagctgca ggag 3423121DNAArtificial
SequencePrimer GVH_R_for_BssHII 231tcagggagaa ctggttcttg g
2123221DNAArtificial SequencePrimer G_VH_F_for_SalI 232tccaagaacc
agttctccct g 2123345DNAArtificial SequencePrimer scFv_SalI_VH_R
233gcgacgtcga caggactcac cactcgagac ggtgaccagg gtgcc
4523432DNAArtificial SequencePrimer Sal_VH_R_RJ 234gcgacgtcga
caggactcac cactcgagac gg 3223534DNAArtificial SequencePrimer
BssHII_II_VL_F 235gcttggcgcg cactcttcct ctgagctgac ccag
3423622DNAArtificial SequencePrimer scFv_VL_R_for_BssHII
236gcctgagccc cagtgatggt ca 2223720DNAArtificial SequencePrimer
GVL_F_for_XbaI 237accgcctccc tgaccatcac 2023850DNAArtificial
SequencePrimer scFv_XbaI_VL_R 238gcgccgtcta gagttattct actcacctaa
aacggtgagc tgggtccctc 502391401DNAartificialVHPTM heavy chain with
signal sequence 239atgggatgga gctgtatcat cctcttcttg gtggcaacag
ctacaggcgt gcactctcag 60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt
ccgagaccct gtctctgacc 120tgtgccgtgt ccggctactc catctcctcc
ggctactact ggggctggat cagacagcct 180cctggcaagg gcctggagtg
gatcggctcc atctctcaca ccggcaacac ctactacaac 240ccccctctga
agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg
300aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag
aggcggcgga 360atctccagac ctgagtactg gggccagggc accctggtga
ccgtgtcctc tgcctccacc 420aagggcccat cggtcttccc cctggcaccc
tcctccaaga gcacctctgg gggcacagcg 480gccctgggct gcctggtcaa
ggactacttc cccgaaccgg tgacggtgtc gtggaactca 540ggcgccctga
ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac
600tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac
ctacatctgc 660aacgtgaatc acaagcccag caacaccaag gtggacaaga
aagttgagcc caaatcttgt 720gacaaaactc acacatgccc accgtgccca
gcacctgaag ccgcgggggc accgtcagtc 780ttcctcttcc ccccaaaacc
caaggacacc ctcatgatct cccggacccc tgaggtcaca 840tgcgtggtgg
tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac
900ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa
cagcacgtac 960cgtgtggtca gcgtcctcac cgtcctgcac caggactggc
tgaatggcaa ggagtacaag 1020tgcaaggtct ccaacaaagc cctcccagcc
cccatcgaga aaaccatctc caaagccaaa 1080ggtcagcccc gagaaccaca
ggtgtacacc ctgcccccat cccgggagga gatgaccaag 1140aaccaggtca
gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag
1200tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt
gctggactcc 1260gacggctcct tcttcctcta tagcaagctc accgtggaca
agagcaggtg gcagcagggg 1320aacgtcttct catgctccgt gatgcatgag
gctctgcaca accactacac gcagaagagc 1380ctctccctgt ccccgggtaa a
1401240467PRTartificialVHPTM heavy chain with signal sequence
240Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1
5 10 15Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
Lys 20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr
Ser Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro
Gly Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn
Thr Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr Ile Ser
Val Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser Ser Val
Thr Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg Gly Gly
Gly Ile Ser Arg Pro Glu Tyr Trp Gly 115 120 125Gln Gly Thr Leu Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150 155
160Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
165 170 175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala 180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 245 250 255Ala Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280
285Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
290 295 300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390 395
400Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
405 410 415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val 420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 450 455 460Pro Gly
Lys4652411401DNAartificialVH3TM heavy chain with signal sequence
241atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt
gcactctcag 60gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct
gtctctgacc 120tgtgccgtgt ccggctactc catctcctcc ggctactact
ggggctggat cagacagcct 180cctggcaagg gcctggagtg gatcggctcc
atctctcaca ccggcaacac ctactacaac 240ccccctctga agtccagagt
gaccatctcc gtggacacct ccaagaacca gttctccctg 300aagctgtcct
ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcatgggg
360ttcggccgcc cggagtactg gggccagggc accctggtga ccgtgtcctc
tgcctccacc 420aagggcccat cggtcttccc cctggcaccc tcctccaaga
gcacctctgg gggcacagcg 480gccctgggct gcctggtcaa ggactacttc
cccgaaccgg tgacggtgtc gtggaactca 540ggcgccctga ccagcggcgt
gcacaccttc ccggctgtcc tacagtcctc aggactctac 600tccctcagca
gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc
660aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc
caaatcttgt 720gacaaaactc acacatgccc accgtgccca gcacctgaag
ccgcgggggc accgtcagtc 780ttcctcttcc ccccaaaacc caaggacacc
ctcatgatct cccggacccc tgaggtcaca 840tgcgtggtgg tggacgtgag
ccacgaagac cctgaggtca agttcaactg gtacgtggac 900ggcgtggagg
tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac
960cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa
ggagtacaag 1020tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga
aaaccatctc caaagccaaa 1080ggtcagcccc gagaaccaca ggtgtacacc
ctgcccccat cccgggagga gatgaccaag 1140aaccaggtca gcctgacctg
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1200tgggagagca
atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc
1260gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg
gcagcagggg 1320aacgtcttct catgctccgt gatgcatgag gctctgcaca
accactacac gcagaagagc 1380ctctccctgt ccccgggtaa a
1401242467PRTartificialVH3TM heavy chain with signal sequence
242Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1
5 10 15Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
Lys 20 25 30Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr
Ser Ile 35 40 45Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro
Gly Lys Gly 50 55 60Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn
Thr Tyr Tyr Asn65 70 75 80Pro Pro Leu Lys Ser Arg Val Thr Ile Ser
Val Asp Thr Ser Lys Asn 85 90 95Gln Phe Ser Leu Lys Leu Ser Ser Val
Thr Ala Ala Asp Thr Ala Val 100 105 110Tyr Tyr Cys Ala Arg Phe Met
Gly Phe Gly Arg Pro Glu Tyr Trp Gly 115 120 125Gln Gly Thr Leu Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala145 150 155
160Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
165 170 175Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala 180 185 190Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val 195 200 205Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His 210 215 220Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Ser Cys225 230 235 240Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 245 250 255Ala Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280
285Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
290 295 300His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr305 310 315 320Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly 325 330 335Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile 340 345 350Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val 355 360 365Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 370 375 380Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu385 390 395
400Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
405 410 415Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val 420 425 430Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met 435 440 445His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 450 455 460Pro Gly
Lys465243703DNAartificialVL2 light chain with signal sequence
243atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt cgcccggtcg gtggtgggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt cat
703244234PRTartificialVL2 light chain with signal sequence 244Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Ala Arg Ser Val Val 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230245703DNAartificialVL18 light chain with signal sequence
245atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtgt cacgaggagc gtgaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt cat
703246234PRTartificialVL18 light chain with signal sequence 246Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Val Thr Arg Ser Val Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230247703DNAartificialVL25 light chain with signal
sequence
247atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt
gcactcttcc 60tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt
caggatcacc 120tgccagggcg atagcctgag aacctactac gcctcctggt
atcagcagaa gcctggacag 180gcccctgtgc tggtgatcta cggcaagcac
aagaggccat ccggcatccc tgacagattc 240tccggctcct cctctggcaa
taccgcctcc ctgaccatca ctggggctca ggcggaagac 300gaggctgact
attactgtac gacgcggagc aacaagggca acccccatgt tctgttcggc
360ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt
cactctgttc 420ccgccctcct ctgaggagct tcaagccaac aaggccacac
tggtgtgtct cataagtgac 480ttctacccgg gagccgtgac agtggcctgg
aaggcagata gcagccccgt caaggcggga 540gtggagacca ccacaccctc
caaacaaagc aacaacaagt acgcggccag cagctatctg 600agcctgacgc
ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
660gggagcaccg tggagaagac agtggcccct acagaatgtt cat
703248234PRTartificialVL25 light chain with signal sequence 248Met
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly1 5 10
15Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala
20 25 30Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg
Thr 35 40 45Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Val Leu 50 55 60Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro
Asp Arg Phe65 70 75 80Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu
Thr Ile Thr Gly Ala 85 90 95Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Thr Thr Arg Ser Asn Lys 100 105 110Gly Asn Pro His Val Leu Phe Gly
Gly Gly Thr Gln Leu Thr Val Leu 115 120 125Gly Gln Pro Lys Ala Ala
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 130 135 140Glu Glu Leu Gln
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp145 150 155 160Phe
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 165 170
175Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
180 185 190Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
Trp Lys 195 200 205Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
Gly Ser Thr Val 210 215 220Glu Lys Thr Val Ala Pro Thr Glu Cys
Ser225 230
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