U.S. patent application number 13/422313 was filed with the patent office on 2012-10-18 for donor specific antibody libraries. Invention is credited to Ramesh Bhatt, Lawrence Horowitz, Arun K. Kashyap.
Application Number | 20120264647 13/422313 |
Document ID | / |
Family ID | 40220152 |
Filed Date | 2012-10-18 |
United States Patent Application | 20120264647 |
Kind Code | A1 |
Horowitz; Lawrence ; et al. | October 18, 2012 |
The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.
Inventors: | Horowitz; Lawrence; (Atherton, CA) ; Bhatt; Ramesh; (Belmont, CA) ; Kashyap; Arun K.; (Newark, CA) |
Family ID: | 40220152 |
Appl. No.: | 13/422313 |
Filed: | March 16, 2012 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11853795 | Sep 11, 2007 | 8148085 | ||
13422313 | ||||
11748980 | May 15, 2007 | |||
11853795 | ||||
60800787 | May 15, 2006 | |||
60855679 | Oct 30, 2006 | |||
Current U.S. Class: | 506/14 |
Current CPC Class: | C07K 2317/21 20130101; C07K 2317/33 20130101; A61P 31/12 20180101; C07K 2317/55 20130101; C07K 16/1018 20130101; C07K 2317/622 20130101; A61K 2039/505 20130101; C07K 16/005 20130101; A61P 31/16 20180101; C40B 30/04 20130101; C40B 20/04 20130101; C40B 40/02 20130101; C07K 16/1063 20130101; C40B 40/08 20130101; C40B 50/06 20130101 |
Class at Publication: | 506/14 |
International Class: | C40B 40/02 20060101 C40B040/02 |
Sequence CWU 1
1
106118DNAArtificial sequenceDescription of Artificial Sequence
Synthetic oligonucleotide 1tttttttttt tttttttt 18213DNAArtificial
sequenceDescription of Artificial Sequence Synthetic
oligonucleotide 2ggccnnnnng gcc 13330DNAArtificial
sequenceDescription of Artificial Sequence Synthetic
oligonucleotide 3tttttttttt tttttttttt tttttttttt
30439DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 4acn aar gcn tcn tay ctn agy acn agy agy
agy ctn gay 39Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp1
5 10513PRTArtificial SequenceDescription of Artificial Sequence
Synthetic peptide 5Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu
Asp1 5 10639DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 6gcn cgn ggn ath tay tty tay ggn
acn acn tay tty gay 39Ala Arg Gly Ile Tyr Phe Tyr Gly Thr Thr Tyr
Phe Asp1 5 10713PRTArtificial SequenceDescription of Artificial
Sequence Synthetic peptide 7Ala Arg Gly Ile Tyr Phe Tyr Gly Thr Thr
Tyr Phe Asp1 5 10839DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 8rcn mrn gsn wyn tay ytn wry rsn
asn asn wry ytn gay 39Xaa Xaa Xaa Xaa Tyr Leu Xaa Xaa Xaa Xaa Xaa
Leu Asp1 5 10913PRTArtificial SequenceDescription of Artificial
Sequence Synthetic peptide 9Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Asp1 5 1010595PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 10Met Glu Lys Ile Ile Ile
Ile Leu Leu Leu Leu Ala Leu Ala Ala Cys1 5 10 15Ser Gly Ala Leu Pro
Gly Asn Asp Asn Ser Thr Asp Lys Ile Cys Ile 20 25 30Gly Tyr His Ala
Asn Asn Ser Thr Glu Thr Val Asp Thr Leu Thr Glu 35 40 45Lys Asn Val
Glu Val Thr His Ala Thr Glu Leu Val Glu Thr Thr His 50 55 60Asn Gly
Lys Leu Cys Ser Leu Asn Gly Lys Ser Pro Leu Asp Leu Gly65 70 75
80Asp Cys Ser Ile Glu Gly Trp Ile Leu Gly Asn Pro Gln Cys Asp Leu
85 90 95Leu Leu Gly Gly Arg Glu Trp Ser Tyr Ile Val Glu Arg Pro Asn
Ala 100 105 110Pro Asn Gly Leu Cys Tyr Pro Gly Asp Phe Glu Asn Tyr
Glu Glu Leu 115 120 125Arg His Leu Phe Ser Ser Ser Gly Ser Phe Glu
Lys Ile Glu Ile Phe 130 135 140Pro Lys Thr Phe Thr Trp Gly Asn Val
Val Thr Thr Asn Gly Thr Thr145 150 155 160Lys Ala Cys Lys Asp Arg
Ser Gly Gly Ser Ser Phe Tyr Arg Asn Leu 165 170 175Val Trp Leu Thr
Ser Lys Lys Lys Gly Ser Ala Tyr Pro Val Ile Lys 180 185 190Gly Thr
Tyr Asn Asn Thr Arg Gly Glu Asp Ile Leu Ile Ile Trp Gly 195 200
205Ile His His Pro Pro Thr Thr Thr Glu Gln Thr Lys Leu Tyr Gly Asn
210 215 220Ala Asp Thr Tyr Val Ser Val Gly Thr Ser Thr Tyr Asn Arg
Arg Phe225 230 235 240Val Pro Glu Ile Gly Ala Arg Pro Lys Val Asn
Gly Gln Ser Gly Arg 245 250 255Met Asp Phe Tyr Trp Thr Leu Leu Lys
Pro Gly Asp Thr Ile Thr Phe 260 265 270Glu Ser Asn Gly Asn Leu Ile
Ala Pro Arg Tyr Ala Tyr Lys Leu Ile 275 280 285Lys Gly Gly Pro Ser
Gly Ile Glu Tyr Asn Gly Lys Gly Arg Ile Ile 290 295 300Gln Ser Glu
Asp Leu Pro Ile Gly Ala Asn Cys Asn Thr Lys Cys Gln305 310 315
320Thr Pro Gly Gly Ala Ile Asn Thr Ser Lys Pro Phe Gln Asn Ile Ser
325 330 335Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Gly
Ser Leu 340 345 350Lys Leu Ala Thr Gly Leu Arg Asn Val Pro Glu Ile
Ile Glu Arg Arg 355 360 365Arg Lys Ser Arg Gly Leu Phe Gly Ala Ile
Ala Gly Phe Ile Glu Gly 370 375 380Gly Trp Pro Gly Leu Ile Asp Gly
Trp Tyr Gly Phe His His Gln Asn385 390 395 400Ala Gln Gly Thr Gly
Ile Ala Ala Asp Lys Lys Ser Thr Gln Lys Ala 405 410 415Ile Asp Gln
Ile Thr Asn Lys Val Asn Asn Ile Ile Glu Lys Met Asn 420 425 430Thr
Gln Phe Glu Ala Ile Asp His Glu Phe Ser Glu Val Glu Lys Arg 435 440
445Ile Asn Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Thr Asp Ile Trp
450 455 460Ser Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln His
Thr Leu465 470 475 480Asp Leu His Asp Ser Asn Val Lys Asn Leu Tyr
Glu Lys Val Arg Arg 485 490 495Gln Leu Arg Asp Asn Ala Glu Asp Asp
Gly Asn Gly Cys Phe Glu Ile 500 505 510Tyr His Lys Cys Asp Asp Glu
Cys Met Glu Ser Ile Arg Asn Gly Thr 515 520 525Tyr Asp His Pro Glu
Tyr Arg Glu Glu Ser Lys Leu Asn Arg Gln Glu 530 535 540Ile Asp Gly
Val Lys Leu Glu Ser Gly Gly Asn Val Tyr Lys Ile Leu545 550 555
560Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Ala Ala Leu Ile
565 570 575Ala Gly Phe Ile Phe Trp Ala Cys Ser Asn Gly Asn Cys Arg
Cys Thr 580 585 590Ile Cys Ile 59511561PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
11Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp1
5 10 15Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val
Asp 20 25 30Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp
Ile Leu 35 40 45Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile
Pro Pro Leu 50 55 60Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu
Gly Asn Pro Glu65 70 75 80Cys Asp Arg Leu Leu Ser Val Pro Glu Trp
Ser Tyr Ile Met Glu Lys 85 90 95Glu Asn Pro Arg Asp Gly Leu Cys Tyr
Pro Gly Ser Phe Asn Asp Tyr 100 105 110Glu Glu Leu Lys His Leu Leu
Ser Ser Val Lys His Phe Glu Lys Val 115 120 125Lys Ile Leu Pro Lys
Asp Arg Trp Thr Gln His Thr Thr Thr Gly Gly 130 135 140Ser Arg Ala
Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn Met145 150 155
160Val Trp Leu Thr Glu Lys Gly Ser Asn Tyr Pro Val Ala Lys Gly Ser
165 170 175Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly
Val His 180 185 190His Pro Asn Asp Glu Lys Glu Gln Arg Thr Leu Tyr
Gln Asn Val Gly 195 200 205Thr Tyr Val Ser Val Gly Thr Ser Thr Leu
Asn Lys Arg Ser Thr Pro 210 215 220Asp Ile Ala Thr Arg Pro Lys Val
Asn Gly Leu Gly Ser Arg Met Glu225 230 235 240Phe Ser Trp Thr Leu
Leu Asp Met Trp Asp Thr Ile Asn Phe Glu Ser 245 250 255Thr Gly Asn
Leu Ile Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys Arg 260 265 270Gly
Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys Glu 275 280
285Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro Phe
290 295 300His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr
Val Lys305 310 315 320Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg
Asn Val Pro Gln Ile 325 330 335Glu Ser Arg Gly Leu Phe Gly Ala Ile
Ala Gly Phe Ile Glu Gly Gly 340 345 350Trp Gln Gly Met Ile Asp Gly
Trp Tyr Gly Tyr His His Ser Asn Asp 355 360 365Gln Gly Ser Gly Tyr
Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Phe 370 375 380Asp Gly Ile
Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr385 390 395
400Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg Leu
405 410 415Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val
Trp Thr 420 425 430Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu
Arg Thr Leu Asp 435 440 445Phe His Asp Ser Asn Val Lys Asn Leu Tyr
Asp Lys Val Arg Met Gln 450 455 460Leu Arg Asp Asn Val Lys Glu Leu
Gly Asn Gly Cys Phe Glu Phe Tyr465 470 475 480His Lys Cys Asp Asp
Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr 485 490 495Asp Tyr Pro
Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile 500 505 510Lys
Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala Ile 515 520
525Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala Gly
530 535 540Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg
Ile Cys545 550 555 560Ile12561PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 12Met Tyr Lys Val Val Val
Ile Ile Ala Leu Leu Gly Ala Val Lys Gly1 5 10 15Leu Asp Arg Ile Cys
Leu Gly His His Ala Val Ala Asn Gly Thr Ile 20 25 30Val Lys Thr Leu
Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 35 40 45Thr Val Glu
Ser Thr Asn Leu Asn Lys Leu Cys Met Lys Gly Arg Ser 50 55 60Tyr Lys
Asp Leu Gly Asn Cys His Pro Val Gly Met Leu Ile Gly Thr65 70 75
80Pro Val Cys Asp Pro His Leu Thr Gly Thr Trp Asp Thr Leu Ile Glu
85 90 95Arg Glu Asn Ala Ile Ala His Cys Tyr Pro Gly Ala Thr Ile Asn
Glu 100 105 110Glu Ala Leu Arg Gln Lys Ile Met Glu Ser Gly Gly Ile
Ser Lys Met 115 120 125Ser Thr Gly Phe Thr Tyr Gly Ser Ser Ile Thr
Ser Ala Gly Thr Thr 130 135 140Lys Ala Cys Met Arg Asn Gly Gly Asp
Ser Phe Tyr Ala Glu Leu Lys145 150 155 160Trp Leu Val Ser Lys Thr
Lys Gly Gln Asn Phe Pro Gln Thr Thr Asn 165 170 175Thr Tyr Arg Asn
Thr Asp Thr Ala Glu His Leu Ile Ile Trp Gly Ile 180 185 190His His
Pro Ser Ser Thr Gln Glu Lys Asn Asp Leu Tyr Gly Thr Gln 195 200
205Ser Leu Ser Ile Ser Val Glu Ser Ser Thr Tyr Gln Asn Asn Phe Val
210 215 220Pro Val Val Gly Ala Arg Pro Gln Val Asn Gly Gln Ser Gly
Arg Ile225 230 235 240Asp Phe His Trp Thr Leu Val Gln Pro Gly Asp
Asn Ile Thr Phe Ser 245 250 255Asp Asn Gly Gly Leu Ile Ala Pro Ser
Arg Val Ser Lys Leu Thr Gly 260 265 270Arg Asp Leu Gly Ile Gln Ser
Glu Ala Leu Ile Asp Asn Ser Cys Glu 275 280 285Ser Lys Cys Phe Trp
Arg Gly Gly Ser Ile Asn Thr Lys Leu Pro Phe 290 295 300Gln Asn Leu
Ser Pro Arg Thr Val Gly Gln Cys Pro Lys Tyr Val Asn305 310 315
320Gln Arg Ser Leu Leu Leu Ala Thr Gly Met Arg Asn Val Pro Glu Val
325 330 335Val Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile
Glu Asn 340 345 350Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe
Arg His Gln Asn 355 360 365Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr
Lys Ser Thr Gln Ala Ala 370 375 380Ile Asp Gln Ile Thr Gly Lys Leu
Asn Arg Leu Ile Glu Lys Thr Asn385 390 395 400Thr Glu Phe Glu Ser
Ile Glu Ser Glu Phe Ser Glu Thr Glu His Gln 405 410 415Ile Gly Asn
Val Ile Asn Trp Thr Lys Asp Ser Ile Thr Asp Ile Trp 420 425 430Thr
Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile 435 440
445Asp Met Ala Asp Ser Glu Met Leu Asn Leu Tyr Glu Arg Val Arg Lys
450 455 460Gln Leu Arg Gln Asn Ala Glu Glu Asp Gly Lys Gly Cys Phe
Glu Ile465 470 475 480Tyr His Thr Cys Asp Asp Ser Cys Met Glu Ser
Ile Arg Asn Asn Thr 485 490 495Tyr Asp His Ser Gln Tyr Arg Glu Glu
Ala Leu Leu Asn Arg Leu Asn 500 505 510Ile Asn Pro Val Lys Leu Ser
Ser Gly Tyr Lys Asp Ile Ile Leu Trp 515 520 525Phe Ser Phe Gly Glu
Ser Cys Phe Val Leu Leu Ala Val Val Met Gly 530 535 540Leu Val Phe
Phe Cys Leu Lys Asn Gly Asn Met Arg Cys Thr Ile Cys545 550 555
560Ile13570PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 13Met Asn Thr Gln Ile Ile Val Ile Leu Val Leu
Gly Leu Ser Met Val1 5 10 15Lys Ser Asp Lys Ile Cys Leu Gly His His
Ala Val Ala Asn Gly Thr 20 25 30Lys Val Asn Thr Leu Thr Glu Arg Gly
Val Glu Val Val Asn Ala Thr 35 40 45Glu Thr Val Glu Ile Thr Gly Ile
Asp Lys Val Cys Thr Lys Gly Lys 50 55 60Lys Ala Val Asp Leu Gly Ser
Cys Gly Ile Leu Gly Thr Ile Ile Gly65 70 75 80Pro Pro Gln Cys Asp
Leu His Leu Glu Phe Lys Ala Asp Leu Ile Ile 85 90 95Glu Arg Arg Asn
Ser Ser Asp Ile Cys Tyr Pro Gly Arg Phe Thr Asn 100 105 110Glu Glu
Ala Leu Arg Gln Ile Ile Arg Glu Ser Gly Gly Ile Asp Lys 115 120
125Glu Ser Met Gly Phe Arg Tyr Ser Gly Ile Arg Thr Asp Gly Ala Thr
130 135 140Ser Ala Cys Lys Arg Thr Val Ser Ser Phe Tyr Ser Glu Met
Lys Trp145 150 155 160Leu Ser Ser Ser Met Asn Asn Gln Val Phe Pro
Gln Leu Asn Gln Thr 165 170 175Tyr Arg Asn Thr Arg Lys Glu Pro Ala
Leu Ile Val Trp Gly Val His 180 185 190His Ser Ser Ser Leu Asp Glu
Gln Asn Lys Leu Tyr Gly Thr Gly Asn 195 200 205Lys Leu Ile Thr Val
Gly Ser Ser Lys Tyr Gln Gln Ser Phe Ser Pro 210 215 220Ser Pro Gly
Ala Arg Pro Lys Val Asn Gly Gln Ala Gly Arg Ile Asp225 230 235
240Phe His Trp Met Leu Leu Asp Pro Gly Asp Thr Val Thr Phe Thr Phe
245 250 255Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Thr Phe Leu Arg
Ser Asn 260 265 270Ala Pro Ser Gly Ile Glu Tyr Asn Gly Lys Ser Leu
Gly Ile Gln Ser 275 280 285Asp Ala Gln Ile Asp Glu Ser Cys Glu Gly
Glu Cys Phe Tyr Ser Gly 290 295 300Gly Thr Ile Asn Ser Pro Leu Pro
Phe Gln Asn Ile Asp Ser Arg Ala305 310 315 320Val Gly Lys Cys Pro
Arg Tyr Val Lys Gln Ser Ser Leu Pro Leu Ala 325 330 335Leu Gly Met
Lys Asn Val Pro Glu Lys Ile Arg Thr Arg Gly Leu Phe 340 345 350Gly
Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp 355 360
365Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Gln Gly Thr Ala
370 375 380Ala Asp Tyr Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr
Gly Lys385 390 395 400Leu Asn Arg Leu Ile Glu Lys Thr Asn Lys Gln
Phe Glu Leu Ile Asp 405 410 415Asn Glu Phe Thr Glu Val Glu Gln Gln
Ile Gly Asn Val Ile Asn Trp 420 425 430Thr Arg Asp Ser Leu Thr Glu
Ile Trp Ser Tyr Asn Ala Glu Leu Leu 435 440 445Val Ala Met Glu Asn
Gln His Thr Ile Asp Leu Ala Asp Ser Glu Met 450
455 460Asn Lys Leu Tyr Glu Arg Val Arg Arg Gln Leu Arg Glu Asn Ala
Glu465 470 475 480Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Arg
Cys Asp Asp Gln 485 490 495Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr
Asn His Thr Glu Tyr Arg 500 505 510Gln Glu Ala Leu Gln Asn Arg Ile
Met Ile Asn Pro Val Lys Leu Ser 515 520 525Ser Gly Tyr Lys Asp Val
Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys 530 535 540Val Met Leu Leu
Ala Ile Ala Met Gly Leu Ile Phe Met Cys Val Lys545 550 555 560Asn
Gly Asn Leu Arg Cys Thr Ile Cys Ile 565 57014560PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
14Met Asn Thr Gln Ile Leu Ile Leu Ala Leu Val Ala Ile Ile Pro Thr1
5 10 15Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly
Ala 20 25 30Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn
Ala Thr 35 40 45Glu Thr Val Glu Arg Thr Asn Val Pro Arg Ile Cys Ser
Lys Gly Lys 50 55 60Arg Thr Val Asp Leu Gly Gln Cys Gly Leu Leu Gly
Thr Ile Thr Gly65 70 75 80Phe Pro Gln Cys Asp Gln Phe Leu Glu Phe
Ser Ala Asp Leu Ile Ile 85 90 95Glu Arg Arg Glu Gly Asn Asp Val Cys
Tyr Pro Gly Lys Phe Val Asn 100 105 110Glu Glu Ala Leu Arg Gln Ile
Leu Arg Lys Ser Gly Gly Ile Asp Lys 115 120 125Glu Thr Met Gly Phe
Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr 130 135 140Ser Ala Cys
Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp145 150 155
160Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser
165 170 175Tyr Lys Asn Ile Arg Lys Asp Pro Ala Leu Ile Ile Trp Gly
Ile His 180 185 190His Ser Gly Ser Thr Ala Glu Gln Thr Lys Leu Tyr
Gly Ser Gly Asn 195 200 205Lys Leu Ile Thr Val Gly Ser Ser Asn Tyr
Gln Gln Ser Phe Val Pro 210 215 220Ser Pro Gly Ala Arg Pro Gln Val
Asn Gly Gln Ser Gly Arg Ile Asp225 230 235 240Phe His Trp Leu Met
Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe 245 250 255Asn Gly Ala
Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 260 265 270Ser
Met Gly Ile Gln Ser Glu Val Gln Val Asp Ala Asn Cys Glu Gly 275 280
285Asp Cys Tyr His Asp Gly Gly Thr Ile Leu Ser Ser Leu Pro Phe Gln
290 295 300Asn Ile Asn Ser Arg Thr Val Gly Glu Cys Pro Arg Tyr Val
Lys Gln305 310 315 320Glu Ser Leu Leu Leu Ala Thr Gly Met Lys Asn
Val Pro Glu Ile Pro 325 330 335Lys Gly Arg Gly Leu Phe Gly Ala Ile
Ala Gly Phe Ile Glu Asn Gly 340 345 350Trp Glu Gly Leu Val Asp Gly
Trp Tyr Gly Phe Arg His Gln Asn Ala 355 360 365Gln Gly Glu Gly Thr
Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile 370 375 380Asp Gln Ile
Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln385 390 395
400Gln Phe Glu Leu Ile Asp Asn Glu Phe Thr Glu Val Glu Lys Gln Ile
405 410 415Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Leu Thr Glu Met
Trp Ser 420 425 430Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln
His Thr Ile Asp 435 440 445Leu Ala Asp Ser Glu Met Asn Lys Leu Tyr
Glu Arg Val Arg Arg Gln 450 455 460Leu Arg Glu Asn Ala Glu Glu Asp
Gly Thr Gly Cys Phe Glu Ile Phe465 470 475 480His Lys Cys Asp Asp
Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr 485 490 495Asp His Ser
Lys Tyr Arg Glu Glu Ala Ile Gln Asn Arg Ile Gln Ile 500 505 510Asp
Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe 515 520
525Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Ala Met Gly Leu
530 535 540Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile
Cys Ile545 550 555 56015566PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 15Met Glu Ala Arg Leu Leu
Val Leu Leu Cys Ala Phe Ala Ala Thr Asn1 5 10 15Ala Asp Thr Ile Cys
Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 20 25 30Val Asp Thr Val
Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 35 40 45Leu Leu Glu
Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 50 55 60Ala Pro
Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly65 70 75
80Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Ser Ser Trp Ser Tyr Ile
85 90 95Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp
Phe 100 105 110Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val
Ser Ser Phe 115 120 125Glu Lys Phe Glu Ile Phe Pro Lys Thr Ser Ser
Trp Pro Asn His Glu 130 135 140Thr Thr Lys Gly Val Thr Ala Ala Cys
Ser Tyr Ala Gly Ala Ser Ser145 150 155 160Phe Tyr Arg Asn Leu Leu
Trp Leu Thr Lys Lys Gly Ser Ser Tyr Pro 165 170 175Lys Leu Ser Lys
Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 180 185 190Leu Trp
Gly Val His His Pro Pro Thr Gly Thr Asp Gln Gln Ser Leu 195 200
205Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn
210 215 220Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg
Asp Gln225 230 235 240Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu
Glu Pro Gly Asp Thr 245 250 255Ile Thr Phe Glu Ala Thr Gly Asn Leu
Ile Ala Pro Trp Tyr Ala Phe 260 265 270Ala Leu Asn Arg Gly Ser Gly
Ser Gly Ile Ile Thr Ser Asp Ala Pro 275 280 285Val His Asp Cys Asn
Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 290 295 300Ser Ser Leu
Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys305 310 315
320Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg
325 330 335Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile
Ala Gly 340 345 350Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly
Trp Tyr Gly Tyr 355 360 365His His Gln Asn Glu Gln Gly Ser Gly Tyr
Ala Ala Asp Gln Lys Ser 370 375 380Thr Gln Asn Ala Ile Asp Gly Ile
Thr Asn Lys Val Asn Ser Val Ile385 390 395 400Glu Lys Met Asn Thr
Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 405 410 415Leu Glu Arg
Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 420 425 430Leu
Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 435 440
445Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Glu
450 455 460Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly
Asn Gly465 470 475 480Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala
Cys Met Glu Ser Val 485 490 495Arg Asn Gly Thr Tyr Asp Tyr Pro Lys
Tyr Ser Glu Glu Ser Lys Leu 500 505 510Asn Arg Glu Glu Ile Asp Gly
Val Lys Leu Glu Ser Met Gly Val Tyr 515 520 525Gln Ile Leu Ala Ile
Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 530 535 540Val Ser Leu
Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu545 550 555
560Gln Cys Arg Ile Cys Ile 56516552PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
16Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val1
5 10 15Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp
Ile 20 25 30Leu Glu Arg Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly
Val Lys 35 40 45Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu
Leu Gly Asn 50 55 60Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp
Ser Tyr Ile Val65 70 75 80Glu Lys Ala Ser Pro Ala Asn Asp Leu Cys
Tyr Pro Gly Asn Phe Asn 85 90 95Asp Tyr Glu Glu Leu Lys His Leu Leu
Ser Arg Ile Asn His Phe Glu 100 105 110Lys Ile Gln Ile Ile Pro Lys
Ser Ser Trp Ser Asn His Asp Ala Ser 115 120 125Ser Gly Val Ser Ser
Ala Cys Pro Tyr Leu Gly Arg Ser Ser Phe Phe 130 135 140Arg Asn Val
Val Trp Leu Ile Lys Lys Asn Ser Ser Tyr Pro Thr Ile145 150 155
160Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp
165 170 175Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu
Tyr Gln 180 185 190Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr
Leu Asn Gln Arg 195 200 205Leu Val Pro Glu Ile Ala Thr Arg Pro Lys
Val Asn Gly Gln Ser Gly 210 215 220Arg Met Glu Phe Phe Trp Thr Ile
Leu Lys Pro Asn Asp Ala Ile Asn225 230 235 240Phe Glu Ser Asn Gly
Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 245 250 255Val Lys Lys
Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 260 265 270Asn
Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 275 280
285Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys
290 295 300Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg
Asn Thr305 310 315 320Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly
Leu Phe Gly Ala Ile 325 330 335Ala Gly Phe Ile Glu Gly Gly Trp Gln
Gly Met Val Asp Gly Trp Tyr 340 345 350Gly Tyr His His Ser Asn Glu
Gln Gly Ser Gly Tyr Ala Ala Asp Gln 355 360 365Glu Ser Thr Gln Lys
Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 370 375 380Ile Ile Asn
Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe385 390 395
400Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp
405 410 415Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val
Leu Met 420 425 430Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn
Val Lys Asn Leu 435 440 445Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp
Asn Ala Lys Glu Leu Gly 450 455 460Asn Gly Cys Phe Glu Phe Tyr His
Lys Cys Asp Asn Glu Cys Met Glu465 470 475 480Ser Val Lys Asn Gly
Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 485 490 495Arg Leu Asn
Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly 500 505 510Thr
Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 515 520
525Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly
530 535 540Ser Leu Gln Cys Arg Ile Cys Ile545 55017564PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
17Met Leu Ser Ile Val Ile Leu Phe Leu Leu Ile Ala Glu Asn Ser Ser1
5 10 15Gln Asn Thr Tyr Gly Asn Pro Val Ile Cys Met Gly His His Ala
Val 20 25 30Ala Asn Gly Thr Met Val Lys Thr Leu Ala Asp Asp Gln Val
Glu Val 35 40 45Val Thr Ala Gln Glu Leu Val Glu Ser Gln Asn Leu Pro
Glu Leu Cys 50 55 60Pro Ser Pro Leu Arg Leu Val Asp Gly Gln Thr Cys
Asp Ile Ile Asn65 70 75 80Gly Ala Leu Gly Ser Pro Gly Cys Asp His
Leu Asn Gly Ala Glu Trp 85 90 95Asp Val Phe Ile Glu Arg Pro Asn Ala
Val Asp Thr Cys Tyr Pro Phe 100 105 110Asp Val Pro Glu Tyr Gln Ser
Leu Arg Ser Ile Leu Ala Asn Asn Gly 115 120 125Lys Phe Glu Phe Ile
Ala Glu Glu Phe Gln Trp Asn Thr Val Lys Gln 130 135 140Asn Gly Lys
Ser Gly Ala Cys Lys Arg Ala Asn Val Asp Asp Phe Phe145 150 155
160Asn Arg Leu Asn Trp Leu Val Lys Ser Asp Gly Asn Ala Tyr Pro Phe
165 170 175Gln Asn Leu Thr Lys Ile Asn Asn Gly Asp Tyr Ala Arg Leu
Tyr Ile 180 185 190Trp Gly Val His His Pro Ser Thr Ser Thr Glu Gln
Ile Asn Leu Tyr 195 200 205Lys Asn Asn Pro Gly Arg Val Thr Val Ser
Thr Lys Thr Ser Gln Thr 210 215 220Ser Val Val Pro Asp Ile Gly Ser
Arg Pro Leu Val Arg Gly Gln Ser225 230 235 240Gly Arg Val Ser Phe
Tyr Trp Thr Ile Val Glu Pro Gly Asp Leu Ile 245 250 255Val Phe Asn
Thr Ile Gly Asn Leu Ile Ala Pro Arg Gly His Tyr Lys 260 265 270Leu
Asn Asn Gln Lys Lys Ser Thr Ile Leu Asn Thr Ala Ile Pro Ile 275 280
285Gly Ser Cys Val Ser Lys Cys His Thr Asp Lys Gly Ser Leu Ser Thr
290 295 300Thr Lys Pro Phe Gln Asn Ile Ser Arg Ile Ala Val Gly Asp
Cys Pro305 310 315 320Arg Tyr Val Lys Gln Gly Ser Leu Lys Leu Ala
Thr Gly Met Arg Asn 325 330 335Ile Pro Glu Lys Ala Ser Arg Gly Leu
Phe Gly Ala Ile Ala Gly Phe 340 345 350Ile Glu Asn Gly Trp Gln Gly
Leu Ile Asp Gly Trp Tyr Gly Phe Arg 355 360 365His Gln Asn Ala Glu
Gly Thr Gly Thr Ala Ala Asp Leu Lys Ser Thr 370 375 380Gln Ala Ala
Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile Glu385 390 395
400Lys Thr Asn Asp Lys Tyr His Gln Ile Glu Lys Glu Phe Glu Gln Val
405 410 415Glu Gly Arg Ile Gln Asp Leu Glu Asn Tyr Val Glu Asp Thr
Lys Ile 420 425 430Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala
Leu Glu Asn Gln 435 440 445His Thr Ile Asp Val Thr Asp Ser Glu Met
Asn Lys Leu Phe Glu Arg 450 455 460Val Arg Arg Gln Leu Arg Glu Asn
Ala Glu Asp Lys Gly Asn Gly Cys465 470 475 480Phe Glu Ile Phe His
Lys Cys Asp Asn Asn Cys Ile Glu Ser Ile Arg 485 490 495Asn Gly Thr
Tyr Asp His Asp Ile Tyr Arg Asp Glu Ala Ile Asp Asn 500 505 510Arg
Phe Gln Ile Gln Gly Val Lys Leu Thr Gln Gly Tyr Lys Asp Ile 515 520
525Ile Leu Trp Ile Ser Phe Ser Ile Ser Cys Phe Leu Leu Val Ala Leu
530 535 540Leu Leu Ala Phe Ile Leu Trp Ala Cys Gln Asn Gly Asn Ile
Arg Cys545 550 555 560Gln Ile Cys Ile18566PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
18Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Ala Leu Gly1
5 10 15Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu
Gly 20 25 30His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr
Asp Asp 35 40 45Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser
Ser Ser Thr 50 55
60Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys65
70 75 80Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe
Gln 85 90 95Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe
Ser Asn 100 105 110Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu
Arg Ser Leu Val 115 120 125Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr
Glu Gly Phe Thr Trp Thr 130 135 140Gly Val Thr Gln Asn Gly Gly Ser
Asn Ala Cys Lys Arg Gly Pro Gly145 150 155 160Ser Gly Phe Phe Ser
Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 165 170 175Tyr Pro Val
Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 180 185 190Leu
Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 195 200
205Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Arg Arg
210 215 220Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp
Val Arg225 230 235 240Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr
Ile Val Lys Pro Gly 245 250 255Asp Val Leu Val Ile Asn Ser Asn Gly
Asn Leu Ile Ala Pro Arg Gly 260 265 270Tyr Phe Lys Met Arg Thr Gly
Lys Ser Ser Ile Met Arg Ser Asp Ala 275 280 285Pro Ile Asp Thr Cys
Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 290 295 300Pro Asn Asp
Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala305 310 315
320Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met
325 330 335Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala
Ile Ala 340 345 350Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp
Gly Trp Tyr Gly 355 360 365Phe Arg His Gln Asn Ser Glu Gly Thr Gly
Gln Ala Ala Asp Leu Lys 370 375 380Ser Thr Gln Ala Ala Ile Asp Gln
Ile Asn Gly Lys Leu Asn Arg Val385 390 395 400Ile Glu Lys Thr Asn
Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 405 410 415Glu Val Glu
Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 420 425 430Lys
Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 435 440
445Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe
450 455 460Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met
Gly Asn465 470 475 480Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn
Ala Cys Ile Glu Ser 485 490 495Ile Arg Asn Gly Thr Tyr Asp His Asp
Val Tyr Arg Asp Glu Ala Leu 500 505 510Asn Asn Arg Phe Gln Ile Lys
Gly Val Glu Leu Lys Ser Gly Tyr Lys 515 520 525Asp Trp Ile Leu Trp
Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 530 535 540Val Val Leu
Leu Gly Phe Ile Met Trp Ala Cys Gln Arg Gly Asn Ile545 550 555
560Arg Cys Asn Ile Cys Ile 56519565PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
19Met Ile Ala Ile Ile Ile Leu Ala Ile Val Ala Ser Thr Ser Lys Ser1
5 10 15Lys Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Thr Gln
Asp 20 25 30Thr Leu Ile Leu Lys Asn Val Thr Val Thr His Ser Val Glu
Leu Leu 35 40 45Glu Ser Gln Lys Glu Glu Arg Phe Cys Arg Val Leu Asn
Lys Ala Pro 50 55 60Leu Asp Leu Lys Gly Cys Thr Ile Glu Gly Trp Ile
Leu Gly Asn Pro65 70 75 80Gln Cys Asp Ile Leu Leu Gly Asp Gln Arg
Trp Ser Tyr Ile Val Glu 85 90 95Arg Pro Gly Ala Gln Asn Gly Ile Cys
Tyr Pro Gly Ile Leu Asn Glu 100 105 110Leu Glu Glu Leu Lys Ala Leu
Ile Gly Ser Gly Glu Arg Val Gln Arg 115 120 125Phe Glu Met Phe Pro
Lys Ser Thr Trp Ala Gly Val Asp Thr Ser Arg 130 135 140Gly Val Thr
Lys Ala Cys Pro Tyr Ile Ser Gly Ser Ser Phe Tyr Gly145 150 155
160Asn Leu Leu Trp Ile Ile Lys Thr Glu Ser Ala Ala Tyr Pro Val Ile
165 170 175Lys Gly Thr Tyr Asn Asn Thr Gly Ser Gln Pro Ile Leu Tyr
Phe Trp 180 185 190Gly Val His His Pro Pro Asp Thr Asn Glu Gln Asn
Thr Leu Tyr Gly 195 200 205Ser Gly Asp Arg Tyr Val Arg Met Gly Thr
Glu Ser Met Arg Phe Ala 210 215 220Lys Ser Pro Glu Ile Ala Ala Arg
Pro Ala Val Asn Gly Gln Arg Gly225 230 235 240Arg Ile Asp Tyr Tyr
Trp Ser Val Leu Lys Pro Gly Glu Thr Leu Asn 245 250 255Val Glu Ser
Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Tyr Lys Phe 260 265 270Thr
Ser Ser Asn Asn Lys Gly Ala Val Phe Lys Ser Asn Leu Pro Ile 275 280
285Glu Asn Cys Asp Ala Val Cys Gln Thr Val Ala Gly Ala Leu Arg Thr
290 295 300Asn Lys Thr Phe Gln Asn Val Ser Pro Leu Trp Ile Gly Glu
Cys Pro305 310 315 320Lys Tyr Val Lys Ser Asp Ser Leu Arg Leu Ala
Thr Gly Leu Arg Asn 325 330 335Val Pro Gln Ala Glu Thr Arg Gly Leu
Phe Gly Ala Ile Ala Gly Phe 340 345 350Ile Glu Gly Gly Trp Thr Gly
Met Ile Asp Gly Trp Tyr Gly Tyr His 355 360 365His Glu Asn Ser Gln
Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr 370 375 380Gln Lys Ala
Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp385 390 395
400Lys Met Asn Thr Gln Phe Glu Ala Val Asp His Glu Phe Ser Asn Leu
405 410 415Glu Arg Arg Val Asp Asn Leu Asn Lys Arg Met Glu Asp Gly
Phe Leu 420 425 430Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu
Leu Glu Asn Glu 435 440 445Arg Thr Leu Asp Leu His Asp Ala Asn Val
Lys Asn Leu Tyr Glu Lys 450 455 460Val Lys Ser Gln Leu Arg Asp Asn
Ala Lys Asp Leu Gly Asn Gly Cys465 470 475 480Phe Glu Phe Trp His
Lys Cys Asp Asp Glu Cys Ile Asn Ser Val Lys 485 490 495Asn Gly Thr
Tyr Asp Tyr Pro Lys Tyr Gln Asp Glu Ser Lys Leu Asn 500 505 510Arg
Gln Glu Ile Asp Ser Val Lys Leu Glu Asn Leu Gly Val Tyr Gln 515 520
525Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Gly Leu Val Leu Val Gly
530 535 540Leu Ile Ile Ala Met Gly Leu Trp Met Cys Ser Asn Gly Ser
Met Pro545 550 555 560Cys Lys Ile Cys Ile 56520565PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
20Met Ala Val Lys Val Leu His Leu Leu Ile Ile Val Leu Gly Arg Tyr1
5 10 15Ser Ile Ala Asp Lys Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser
Ser 20 25 30Asp Thr Val Asp Thr Leu Thr Glu Asn Gly Val Pro Val Thr
Ser Ser 35 40 45Ile Asp Leu Val Glu Thr Asn His Thr Gly Thr Tyr Cys
Ser Leu Asn 50 55 60Gly Ile Ser Pro Ile His Leu Gly Asp Cys Ser Phe
Glu Gly Trp Ile65 70 75 80Val Gly Asn Pro Ser Cys Ala Thr Asn Ile
Asn Ile Arg Glu Trp Ser 85 90 95Tyr Leu Ile Glu Asp Pro Asn Ala Pro
Asn Lys Leu Cys Phe Pro Gly 100 105 110Glu Leu Asp Asn Asn Gly Glu
Leu Arg His Leu Phe Ser Gly Val Asn 115 120 125Ser Phe Ser Arg Thr
Glu Leu Ile Ser Pro Ser Lys Trp Gly Asp Val 130 135 140Leu Asp Gly
Val Thr Ala Ser Cys Leu Asp Lys Gly Ala Ser Ser Phe145 150 155
160Tyr Arg Asn Leu Val Trp Leu Val Lys Gln Asn Asp Arg Tyr Pro Val
165 170 175Val Arg Gly Asp Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu
Val Leu 180 185 190Trp Gly Ile His His Pro Asp Thr Glu Thr Thr Ala
Thr Lys Leu Tyr 195 200 205Val Asn Lys Asn Pro Tyr Thr Leu Val Ser
Thr Lys Glu Trp Ser Lys 210 215 220Arg Tyr Glu Leu Glu Ile Gly Thr
Arg Ile Gly Asp Gly Gln Arg Ser225 230 235 240Trp Met Lys Ile Tyr
Trp His Leu Met His Pro Gly Glu Arg Ile Met 245 250 255Phe Glu Ser
Asn Gly Gly Leu Leu Ala Pro Arg Tyr Gly Tyr Ile Ile 260 265 270Glu
Lys Tyr Gly Thr Gly Arg Ile Phe Gln Ser Gly Ile Arg Met Ala 275 280
285Lys Cys Asn Thr Lys Cys Gln Thr Ser Met Gly Gly Val Asn Thr Asn
290 295 300Lys Thr Phe Gln Asn Ile Glu Arg Asn Ala Leu Gly Asp Cys
Pro Lys305 310 315 320Tyr Ile Lys Ser Gly Gln Leu Lys Leu Ala Thr
Gly Leu Arg Asn Val 325 330 335Pro Ser Ile Gly Glu Arg Gly Leu Phe
Gly Ala Ile Ala Gly Phe Ile 340 345 350Glu Gly Gly Trp Pro Gly Leu
Ile Asn Gly Trp Tyr Gly Phe Gln His 355 360 365Gln Asn Glu Gln Gly
Thr Gly Ile Ala Ala Asp Lys Ala Ser Thr Gln 370 375 380Lys Ala Ile
Asn Glu Ile Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys385 390 395
400Met Asn Gly Asn Thr Asp Ser Ile Arg Gly Glu Phe Asn Gln Val Glu
405 410 415Lys Arg Ile Asn Met Leu Ala Asp Arg Val Asp Asp Ala Val
Thr Asp 420 425 430Ile Trp Ser Tyr Asn Ala Lys Leu Leu Val Leu Ile
Glu Asn Asp Arg 435 440 445Thr Leu Asp Leu His Asp Ala Asn Val Lys
Asn Leu His Glu Gln Val 450 455 460Lys Arg Ala Leu Lys Asn Asn Ala
Ile Asp Glu Gly Asp Gly Cys Phe465 470 475 480Asn Leu Leu His Lys
Cys Asn Asp Ser Cys Met Glu Thr Ile Arg Asn 485 490 495Gly Thr Tyr
Asn His Glu Asp Tyr Arg Glu Glu Ser Gln Leu Lys Arg 500 505 510Gln
Glu Ile Glu Gly Ile Lys Leu Lys Thr Glu Asp Asn Val Tyr Lys 515 520
525Val Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile Val Met Val Gly
530 535 540Leu Ile Leu Ala Phe Ile Met Trp Ala Cys Ser Ser Gly Asn
Cys Arg545 550 555 560Phe Asn Val Cys Ile 56521565PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
21Met Glu Lys Phe Ile Ala Ile Ala Thr Leu Ala Ser Thr Asn Ala Tyr1
5 10 15Asp Arg Ile Cys Ile Gly Tyr Gln Ser Asn Asn Ser Thr Asp Thr
Val 20 25 30Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Thr Met
Glu Leu 35 40 45Val Glu Thr Glu Lys His Pro Ala Tyr Cys Asn Thr Asp
Leu Gly Ala 50 55 60Pro Leu Glu Leu Arg Asp Cys Lys Ile Glu Ala Val
Ile Tyr Gly Asn65 70 75 80Pro Lys Cys Asp Ile His Leu Lys Asp Gln
Gly Trp Ser Tyr Ile Val 85 90 95Glu Arg Pro Ser Ala Pro Glu Gly Met
Cys Tyr Pro Gly Ser Val Glu 100 105 110Asn Leu Glu Glu Leu Arg Phe
Val Phe Ser Ser Ala Ala Ser Tyr Lys 115 120 125Arg Ile Arg Leu Phe
Asp Tyr Ser Arg Trp Asn Val Thr Arg Ser Gly 130 135 140Thr Ser Lys
Ala Cys Asn Ala Ser Thr Gly Gly Gln Ser Phe Tyr Arg145 150 155
160Ser Ile Asn Trp Leu Thr Lys Lys Glu Pro Asp Thr Tyr Asp Phe Asn
165 170 175Glu Gly Ala Tyr Val Asn Asn Glu Asp Gly Asp Ile Ile Phe
Leu Trp 180 185 190Gly Ile His His Pro Pro Asp Thr Lys Glu Gln Thr
Thr Leu Tyr Lys 195 200 205Asn Ala Asn Thr Leu Ser Ser Val Thr Thr
Asn Thr Ile Asn Arg Ser 210 215 220Phe Gln Pro Asn Ile Gly Pro Arg
Pro Leu Val Arg Gly Gln Gln Gly225 230 235 240Arg Met Asp Tyr Tyr
Trp Gly Ile Leu Lys Arg Gly Glu Thr Leu Lys 245 250 255Ile Arg Thr
Asn Gly Asn Leu Ile Ala Pro Glu Phe Gly Tyr Leu Leu 260 265 270Lys
Gly Glu Ser Tyr Gly Arg Ile Ile Gln Asn Glu Asp Ile Pro Ile 275 280
285Gly Asn Cys Asn Thr Lys Cys Gln Thr Tyr Ala Gly Ala Ile Asn Ser
290 295 300Ser Lys Pro Phe Gln Asn Ala Ser Arg His Tyr Met Gly Glu
Cys Pro305 310 315 320Lys Tyr Val Lys Lys Ala Ser Leu Arg Leu Ala
Val Gly Leu Arg Asn 325 330 335Thr Pro Ser Val Glu Pro Arg Gly Leu
Phe Gly Ala Ile Ala Gly Phe 340 345 350Ile Glu Gly Gly Trp Ser Gly
Met Ile Asp Gly Trp Tyr Gly Phe His 355 360 365His Ser Asn Ser Glu
Gly Thr Gly Met Ala Ala Asp Gln Lys Ser Thr 370 375 380Gln Glu Ala
Ile Asp Lys Ile Thr Asn Lys Val Asn Asn Ile Val Asp385 390 395
400Lys Met Asn Arg Glu Phe Glu Val Val Asn His Glu Phe Ser Glu Val
405 410 415Glu Lys Arg Ile Asn Met Ile Asn Asp Lys Ile Asp Asp Gln
Ile Glu 420 425 430Asp Leu Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu
Leu Glu Asn Gln 435 440 445Lys Thr Leu Asp Glu His Asp Ser Asn Val
Lys Asn Leu Phe Asp Glu 450 455 460Val Lys Arg Arg Leu Ser Ala Asn
Ala Ile Asp Ala Gly Asn Gly Cys465 470 475 480Phe Asp Ile Leu His
Lys Cys Asp Asn Glu Cys Met Glu Thr Ile Lys 485 490 495Asn Gly Thr
Tyr Asp His Lys Glu Tyr Glu Glu Glu Ala Lys Leu Glu 500 505 510Arg
Ser Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Thr Thr Tyr Lys 515 520
525Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu Cys Leu Ala Ile
530 535 540Leu Ile Ala Gly Gly Leu Ile Leu Gly Met Gln Asn Gly Ser
Cys Arg545 550 555 560Cys Met Phe Cys Ile 56522565PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
22Met Glu Lys Thr Leu Leu Phe Ala Ala Ile Phe Leu Cys Val Lys Ala1
5 10 15Asp Glu Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Thr Asp Lys
Val 20 25 30Asp Thr Ile Ile Glu Asn Asn Val Thr Val Thr Ser Ser Val
Glu Leu 35 40 45Val Glu Thr Glu His Thr Gly Ser Phe Cys Ser Ile Asn
Gly Lys Gln 50 55 60Pro Ile Ser Leu Gly Asp Cys Ser Phe Ala Gly Trp
Ile Leu Gly Asn65 70 75 80Pro Met Cys Asp Glu Leu Ile Gly Lys Thr
Ser Trp Ser Tyr Ile Val 85 90 95Glu Lys Pro Asn Pro Thr Asn Gly Ile
Cys Tyr Pro Gly Thr Leu Glu 100 105 110Ser Glu Glu Glu Leu Arg Leu
Lys Phe Ser Gly Val Leu Glu Phe Asn 115 120 125Lys Phe Glu Val Phe
Thr Ser Asn Gly Trp Gly Ala Val Asn Ser Gly 130 135 140Val Gly Val
Thr Ala Ala Cys Lys Phe Gly Gly Ser Asn Ser Phe Phe145 150 155
160Arg Asn Met Val Trp Leu Ile His Gln Ser Gln Thr Tyr Pro Val Ile
165 170 175Lys Arg Thr Phe Asn Asn Thr Lys Gly Arg Asp Val Leu Ile
Val Trp 180 185 190Gly Ile His His Pro Ala Thr Leu Thr Glu His Gln
Asp Leu Tyr Lys 195 200 205Lys Asp Ser Ser Tyr Val Ala Val Gly Ser
Glu Thr Tyr Asn Arg Arg 210 215 220Phe Thr Pro
Glu Ile Asn Thr Arg Pro Arg Val Asn Gly Gln Ala Gly225 230 235
240Arg Met Thr Phe Tyr Trp Lys Ile Val Lys Pro Gly Glu Ser Ile Thr
245 250 255Phe Glu Ser Asn Gly Ala Phe Leu Ala Pro Arg Tyr Ala Phe
Glu Ile 260 265 270Val Ser Val Gly Asn Gly Lys Leu Phe Arg Ser Glu
Leu Asn Ile Glu 275 280 285Ser Cys Ser Thr Lys Cys Gln Thr Glu Ile
Gly Gly Ile Asn Thr Asn 290 295 300Lys Ser Phe His Asn Val His Arg
Asn Thr Ile Gly Asp Cys Pro Lys305 310 315 320Tyr Val Asn Val Lys
Ser Leu Lys Leu Ala Thr Gly Pro Arg Asn Val 325 330 335Pro Ala Ile
Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 340 345 350Glu
Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 355 360
365Arg Asp Glu Glu Gly Thr Gly Ile Ala Ala Asp Lys Glu Ser Thr Gln
370 375 380Lys Ala Ile Asp Gln Ile Thr Ser Lys Val Asn Asn Ile Val
Asp Arg385 390 395 400Met Asn Thr Asn Phe Glu Ser Val Gln His Glu
Phe Ser Glu Ile Glu 405 410 415Glu Arg Ile Asn Gln Leu Ser Lys His
Val Asp Asp Ser Val Val Asp 420 425 430Ile Trp Ser Tyr Asn Ala Gln
Leu Leu Val Leu Leu Glu Asn Glu Lys 435 440 445Thr Leu Asp Leu His
Asp Ser Asn Val Arg Asn Leu His Glu Lys Val 450 455 460Arg Arg Met
Leu Lys Asp Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe465 470 475
480Thr Phe Tyr His Lys Cys Asp Asn Lys Cys Ile Glu Arg Val Arg Asn
485 490 495Gly Thr Tyr Asp His Lys Glu Phe Glu Glu Glu Ser Lys Ile
Asn Arg 500 505 510Gln Glu Ile Glu Gly Val Lys Leu Asp Ser Ser Gly
Asn Val Tyr Lys 515 520 525Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser
Ser Leu Val Leu Ala Ala 530 535 540Leu Ile Met Gly Phe Met Phe Trp
Ala Cys Ser Asn Gly Ser Cys Arg545 550 555 560Cys Thr Ile Cys Ile
56523564PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 23Met Glu Lys Phe Ile Ile Leu Ser Thr Val Leu
Ala Ala Ser Phe Ala1 5 10 15Tyr Asp Lys Ile Cys Ile Gly Tyr Gln Thr
Asn Asn Ser Thr Glu Thr 20 25 30Val Asn Thr Leu Ser Glu Gln Asn Val
Pro Val Thr Gln Val Glu Glu 35 40 45Leu Val His Arg Gly Ile Asp Pro
Ile Leu Cys Gly Thr Glu Leu Gly 50 55 60Ser Pro Leu Val Leu Asp Asp
Cys Ser Leu Glu Gly Leu Ile Leu Gly65 70 75 80Asn Pro Lys Cys Asp
Leu Tyr Leu Asn Gly Arg Glu Trp Ser Tyr Ile 85 90 95Val Glu Arg Pro
Lys Glu Met Glu Gly Val Cys Tyr Pro Gly Ser Ile 100 105 110Glu Asn
Gln Glu Glu Leu Arg Ser Leu Phe Ser Ser Ile Lys Lys Tyr 115 120
125Glu Arg Val Lys Met Phe Asp Phe Thr Lys Trp Asn Val Thr Tyr Thr
130 135 140Gly Thr Ser Lys Ala Cys Asn Asn Thr Ser Asn Gln Gly Ser
Phe Tyr145 150 155 160Arg Ser Met Arg Trp Leu Thr Leu Lys Ser Gly
Gln Phe Pro Val Gln 165 170 175Thr Asp Glu Tyr Lys Asn Thr Arg Asp
Ser Asp Ile Val Phe Thr Trp 180 185 190Ala Ile His His Pro Pro Thr
Ser Asp Glu Gln Val Lys Leu Tyr Lys 195 200 205Asn Pro Asp Thr Leu
Ser Ser Val Thr Thr Val Glu Ile Asn Arg Ser 210 215 220Phe Lys Pro
Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly225 230 235
240Arg Met Asp Tyr Tyr Trp Ala Val Leu Lys Pro Gly Gln Thr Val Lys
245 250 255Ile Gln Thr Asn Gly Asn Leu Ile Ala Pro Glu Tyr Gly His
Leu Ile 260 265 270Thr Gly Lys Ser His Gly Arg Ile Leu Lys Asn Asn
Leu Pro Met Gly 275 280 285Gln Cys Val Thr Glu Cys Gln Leu Asn Glu
Gly Val Met Asn Thr Ser 290 295 300Lys Pro Phe Gln Asn Thr Ser Lys
His Tyr Ile Gly Lys Cys Pro Lys305 310 315 320Tyr Ile Pro Ser Gly
Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val 325 330 335Pro Gln Val
Gln Asp Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 340 345 350Glu
Gly Gly Trp Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His 355 360
365Gln Asn Ala Glu Gly Thr Gly Ile Ala Ala Asp Arg Asp Ser Thr Gln
370 375 380Arg Ala Ile Asp Asn Met Gln Asn Lys Leu Asn Asn Val Ile
Asp Lys385 390 395 400Met Asn Lys Gln Phe Glu Val Val Asn His Glu
Phe Ser Glu Val Glu 405 410 415Ser Arg Ile Asn Met Ile Asn Ser Lys
Ile Asp Asp Gln Ile Thr Asp 420 425 430Ile Trp Ala Tyr Asn Ala Glu
Leu Leu Val Leu Leu Glu Asn Gln Lys 435 440 445Thr Leu Asp Glu His
Asp Ala Asn Val Arg Asn Leu His Asp Arg Val 450 455 460Arg Arg Val
Leu Arg Glu Asn Ala Ile Asp Thr Gly Asp Gly Cys Phe465 470 475
480Glu Ile Leu His Lys Cys Asp Asn Asn Cys Met Asp Thr Ile Arg Asn
485 490 495Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ser Lys Ile
Glu Arg 500 505 510Gln Lys Val Asn Gly Val Lys Leu Glu Glu Asn Ser
Thr Tyr Lys Ile 515 520 525Leu Ser Ile Tyr Ser Ser Val Ala Ser Ser
Leu Val Leu Leu Leu Met 530 535 540Ile Ile Gly Gly Phe Ile Phe Gly
Cys Gln Asn Gly Asn Val Arg Cys545 550 555 560Thr Phe Cys
Ile24566PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 24Met Ala Leu Asn Val Ile Ala Thr Leu Thr Leu
Ile Ser Val Cys Val1 5 10 15His Ala Asp Arg Ile Cys Val Gly Tyr Leu
Ser Thr Asn Ser Ser Glu 20 25 30Arg Val Asp Thr Leu Leu Glu Asn Gly
Val Pro Val Thr Ser Ser Ile 35 40 45Asp Leu Ile Glu Thr Asn His Thr
Gly Thr Tyr Cys Ser Leu Asn Gly 50 55 60Val Ser Pro Val His Leu Gly
Asp Cys Ser Phe Glu Gly Trp Ile Val65 70 75 80Gly Asn Pro Ala Cys
Thr Ser Asn Phe Gly Ile Arg Glu Trp Ser Tyr 85 90 95Leu Ile Glu Asp
Pro Ala Ala Pro His Gly Leu Cys Tyr Pro Gly Glu 100 105 110Leu Asn
Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Ile Arg Ser 115 120
125Phe Ser Arg Thr Glu Leu Ile Pro Pro Thr Ser Trp Gly Glu Val Leu
130 135 140Asp Gly Thr Thr Ser Ala Cys Arg Asp Asn Thr Gly Thr Asn
Ser Phe145 150 155 160Tyr Arg Asn Leu Val Trp Phe Ile Lys Lys Asn
Thr Arg Tyr Pro Val 165 170 175Ile Ser Lys Thr Tyr Asn Asn Thr Thr
Gly Arg Asp Val Leu Val Leu 180 185 190Trp Gly Ile His His Pro Val
Ser Val Asp Glu Thr Lys Thr Leu Tyr 195 200 205Val Asn Ser Asp Pro
Tyr Thr Leu Val Ser Thr Lys Ser Trp Ser Glu 210 215 220Lys Tyr Lys
Leu Glu Thr Gly Val Arg Pro Gly Tyr Asn Gly Gln Arg225 230 235
240Ser Trp Met Lys Ile Tyr Trp Ser Leu Ile His Pro Gly Glu Met Ile
245 250 255Thr Phe Glu Ser Asn Gly Gly Phe Leu Ala Pro Arg Tyr Gly
Tyr Ile 260 265 270Ile Glu Glu Tyr Gly Lys Gly Arg Ile Phe Gln Ser
Arg Ile Arg Met 275 280 285Ser Arg Cys Asn Thr Lys Cys Gln Thr Ser
Val Gly Gly Ile Asn Thr 290 295 300Asn Arg Thr Phe Gln Asn Ile Asp
Lys Asn Ala Leu Gly Asp Cys Pro305 310 315 320Lys Tyr Ile Lys Ser
Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn 325 330 335Val Pro Ala
Ile Ser Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 340 345 350Ile
Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln 355 360
365His Gln Asn Glu Gln Gly Thr Gly Ile Ala Ala Asp Lys Glu Ser Thr
370 375 380Gln Lys Ala Ile Asp Gln Ile Thr Thr Lys Ile Asn Asn Ile
Ile Asp385 390 395 400Lys Met Asn Gly Asn Tyr Asp Ser Ile Arg Gly
Glu Phe Asn Gln Val 405 410 415Glu Lys Arg Ile Asn Met Leu Ala Asp
Arg Ile Asp Asp Ala Val Thr 420 425 430Asp Ile Trp Ser Tyr Asn Ala
Lys Leu Leu Val Leu Leu Glu Asn Asp 435 440 445Lys Thr Leu Asp Met
His Asp Ala Asn Val Lys Asn Leu His Glu Gln 450 455 460Val Arg Arg
Glu Leu Lys Asp Asn Ala Ile Asp Glu Gly Asn Gly Cys465 470 475
480Phe Glu Leu Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg
485 490 495Asn Gly Thr Tyr Asp His Thr Glu Tyr Ala Glu Glu Ser Lys
Leu Lys 500 505 510Arg Gln Glu Ile Asp Gly Ile Lys Leu Lys Ser Glu
Asp Asn Val Tyr 515 520 525Lys Ala Leu Ser Ile Tyr Ser Cys Ile Ala
Ser Ser Val Val Leu Val 530 535 540Gly Leu Ile Leu Ser Phe Ile Met
Trp Ala Cys Ser Ser Gly Asn Cys545 550 555 560Arg Phe Asn Val Cys
Ile 56525559PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptide 25Met Glu Thr Ile Ser Leu Ile Thr
Ile Leu Leu Val Val Thr Ala Ser1 5 10 15Asn Ala Asp Lys Ile Cys Ile
Gly His Gln Ser Thr Asn Ser Thr Glu 20 25 30Thr Val Asp Thr Leu Thr
Glu Thr Asn Val Pro Val Thr His Ala Lys 35 40 45Glu Leu Leu His Thr
Glu His Asn Gly Met Leu Cys Ala Thr Ser Leu 50 55 60Gly His Pro Leu
Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Val Tyr65 70 75 80Gly Asn
Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 85 90 95Ile
Val Glu Arg Ser Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 100 105
110Val Glu Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ala Ser Ser
115 120 125Tyr Gln Arg Ile Gln Ile Phe Pro Asp Thr Thr Asn Val Val
Tyr Thr 130 135 140Asn Gly Ser Arg Ala Cys Ser Gly Ser Phe Tyr Arg
Ser Met Arg Trp145 150 155 160Leu Ile Gln Lys Ser Gly Phe Tyr Pro
Val Gln Asp Ala Gln Tyr Thr 165 170 175Asn Asn Arg Gly Lys Ser Ile
Leu Phe Val Trp Gly Ile His His Pro 180 185 190Pro Thr Tyr Thr Glu
Gln Thr Asn Leu Tyr Ile Arg Asn Asp Thr Thr 195 200 205Thr Ser Val
Thr Thr Glu Asp Leu Asn Arg Thr Phe Lys Pro Val Ile 210 215 220Gly
Pro Arg Pro Leu Val Asn Gly Leu Gln Gly Arg Ile Asp Tyr Tyr225 230
235 240Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn
Gly 245 250 255Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly
Gly Ser His 260 265 270Gly Arg Ile Leu Lys Tyr Asp Leu Lys Gly Gly
Asn Cys Val Val Gln 275 280 285Cys Gln Thr Glu Lys Gly Gly Leu Asn
Ser Thr Leu Pro Phe His Asn 290 295 300Ile Ser Lys Tyr Ala Phe Gly
Thr Cys Pro Lys Tyr Val Arg Val Asn305 310 315 320Ser Leu Lys Leu
Ala Val Gly Leu Arg Asn Val Pro Ala Arg Ser Ser 325 330 335Arg Gly
Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro 340 345
350Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln Gly
355 360 365Val Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Ile
Asp Lys 370 375 380Ile Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met
Asn Lys Gln Tyr385 390 395 400Glu Ile Ile Asp His Glu Phe Ser Glu
Val Glu Thr Arg Leu Asn Met 405 410 415Ile Asn Asn Lys Ile Asp Asp
Gln Ile Gln Asp Val Trp Ala Tyr Asn 420 425 430Ala Glu Leu Leu Val
Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His 435 440 445Asp Ala Asn
Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu Gly 450 455 460Ser
Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His Lys465 470
475 480Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn
Arg 485 490 495Arg Lys Tyr Arg Glu Glu Ser Arg Leu Glu Arg Gln Lys
Ile Glu Gly 500 505 510Val Lys Leu Glu Ser Glu Gly Thr Tyr Lys Ile
Leu Thr Ile Tyr Ser 515 520 525Thr Val Ala Ser Ser Leu Val Leu Ala
Met Gly Phe Ala Ala Phe Leu 530 535 540Phe Trp Ala Asn Ser Asn Gly
Ser Cys Arg Cys Asn Ile Cys Ile545 550 55526533PRTInfluenza A virus
26Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys1
5 10 15Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu
Ile 20 25 30Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro
Met Cys 35 40 45Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val
Glu Lys Ile 50 55 60Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe
Asn Asp Tyr Glu65 70 75 80Glu Leu Lys His Leu Leu Ser Arg Ile Asn
His Phe Glu Lys Ile Gln 85 90 95Ile Ile Pro Lys Ser Ser Trp Ser Asp
His Glu Ala Ser Ser Gly Val 100 105 110Ser Ser Ala Cys Pro Tyr Gln
Gly Arg Ser Ser Phe Phe Arg Asn Val 115 120 125Val Trp Leu Ile Lys
Lys Asn Asn Ala Tyr Pro Thr Ile Lys Arg Ser 130 135 140Tyr Asn Asn
Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His145 150 155
160His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr
165 170 175Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu
Val Pro 180 185 190Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Asn
Gly Arg Met Glu 195 200 205Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp
Ala Ile Asn Phe Glu Ser 210 215 220Asn Gly Asn Phe Ile Ala Pro Glu
Asn Ala Tyr Lys Ile Val Lys Lys225 230 235 240Gly Asp Ser Thr Ile
Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 245 250 255Thr Lys Cys
Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser Met Pro Phe 260 265 270His
Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys 275 280
285Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly
290 295 300Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala
Gly Phe305 310 315 320Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly
Trp Tyr Gly Tyr His 325 330 335His Ser Asn Glu Gln Gly Ser Gly Tyr
Ala Ala Asp Lys Glu Ser Thr 340 345 350Gln Lys Ala Ile Asp Gly Val
Thr Asn Lys Val Asn Ser Ile Ile Asp 355 360 365Lys Met Asn Thr Gln
Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu 370 375 380Glu Arg Arg
Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu385 390 395
400Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn
Glu 405 410 415Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu
Tyr Asp Lys 420 425 430Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu
Leu Gly Asn Gly Cys 435 440 445Phe Glu Phe Tyr His Arg Cys Asp Asn
Glu Cys Met Glu Ser Val Arg 450 455 460Asn Gly Thr Tyr Asp Tyr Pro
Gln Tyr Ser Glu Glu Ala Arg Leu Lys465 470 475 480Arg Glu Glu Ile
Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln 485 490 495Ile Leu
Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile 500 505
510Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln
515 520 525Cys Arg Ile Cys Ile 53027533PRTInfluenza A virus 27Met
Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys1 5 10
15Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile
20 25 30Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met
Cys 35 40 45Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val Glu
Lys Ile 50 55 60Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn
Asp Tyr Glu65 70 75 80Glu Leu Lys His Leu Leu Ser Arg Ile Asn His
Phe Glu Lys Ile Gln 85 90 95Ile Ile Pro Lys Ser Ser Trp Ser Asp His
Glu Ala Ser Ser Gly Val 100 105 110Ser Ser Ala Cys Pro Tyr Gln Gly
Arg Ser Ser Phe Phe Arg Asn Val 115 120 125Val Trp Leu Ile Lys Lys
Asp Asn Ala Tyr Pro Thr Ile Lys Arg Ser 130 135 140Tyr Asn Asn Thr
Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His145 150 155 160His
Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr 165 170
175Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro
180 185 190Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Asn Gly Arg
Met Glu 195 200 205Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile
Asn Phe Glu Ser 210 215 220Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala
Tyr Lys Ile Val Lys Lys225 230 235 240Gly Asp Ser Thr Ile Met Lys
Ser Glu Leu Glu Tyr Gly Asn Cys Asn 245 250 255Thr Lys Cys Gln Thr
Pro Ile Gly Ala Ile Asn Ser Ser Met Pro Phe 260 265 270His Asn Ile
His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys 275 280 285Ser
Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly 290 295
300Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly
Phe305 310 315 320Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp
Tyr Gly Tyr His 325 330 335His Ser Asn Glu Gln Gly Ser Gly Tyr Ala
Ala Asp Lys Glu Ser Thr 340 345 350Gln Lys Ala Ile Asp Gly Val Thr
Asn Lys Val Asn Ser Ile Ile Asp 355 360 365Lys Met Asn Thr Gln Phe
Glu Ala Val Gly Arg Glu Phe Asn Asn Leu 370 375 380Glu Arg Arg Ile
Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu385 390 395 400Asp
Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu 405 410
415Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys
420 425 430Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn
Gly Cys 435 440 445Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met
Glu Ser Val Arg 450 455 460Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser
Glu Glu Ala Arg Leu Lys465 470 475 480Arg Glu Glu Ile Ser Gly Val
Lys Leu Glu Ser Ile Gly Thr Tyr Gln 485 490 495Ile Leu Ser Ile Tyr
Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile 500 505 510Met Val Ala
Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 515 520 525Cys
Arg Ile Cys Ile 53028533PRTInfluenza A virus 28Met Glu Lys Asn Val
Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys1 5 10 15Thr His Asn Gly
Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 20 25 30Leu Arg Asp
Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 35 40 45Asp Glu
Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ile 50 55 60Asn
Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu65 70 75
80Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln
85 90 95Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser Ser Gly
Val 100 105 110Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe
Arg Asn Val 115 120 125Val Trp Leu Ile Lys Lys Asp Asn Ala Tyr Pro
Thr Ile Lys Arg Ser 130 135 140Tyr Asn Asn Thr Asn Gln Glu Asp Leu
Leu Val Leu Trp Gly Ile His145 150 155 160His Pro Asn Asp Ala Ala
Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr 165 170 175Thr Tyr Ile Ser
Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 180 185 190Lys Ile
Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 195 200
205Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser
210 215 220Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile Val
Lys Lys225 230 235 240Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu
Tyr Gly Asn Cys Asn 245 250 255Thr Lys Cys Gln Thr Pro Ile Gly Ala
Ile Asn Ser Ser Met Pro Phe 260 265 270His Asn Ile His Pro Leu Thr
Ile Gly Glu Cys Pro Lys Tyr Val Lys 275 280 285Ser Asn Arg Leu Val
Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly 290 295 300Glu Arg Arg
Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe305 310 315
320Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His
325 330 335His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu
Ser Thr 340 345 350Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn
Ser Ile Ile Asp 355 360 365Lys Met Asn Thr Gln Phe Glu Ala Val Gly
Arg Glu Phe Asn Asn Leu 370 375 380Glu Arg Arg Ile Glu Asn Leu Asn
Lys Lys Met Glu Asp Gly Phe Leu385 390 395 400Asp Val Trp Thr Tyr
Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu 405 410 415Arg Thr Leu
Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys 420 425 430Val
Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys 435 440
445Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser Val Arg
450 455 460Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg
Leu Lys465 470 475 480Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser
Ile Gly Thr Tyr Gln 485 490 495Ile Leu Ser Ile Tyr Ser Thr Val Ala
Ser Ser Leu Ala Leu Ala Ile 500 505 510Met Val Ala Gly Leu Ser Leu
Trp Met Cys Ser Asn Gly Ser Leu Gln 515 520 525Cys Arg Ile Cys Ile
53029533PRTInfluenza A virus 29Met Glu Lys Asn Val Thr Val Thr His
Ala Gln Asp Ile Leu Glu Lys1 5 10 15Thr His Asn Gly Lys Leu Cys Asp
Leu Asp Gly Val Lys Pro Leu Ile 20 25 30Leu Arg Asp Cys Ser Val Ala
Gly Trp Leu Leu Gly Asn Pro Met Cys 35 40 45Asp Glu Phe Leu Asn Val
Pro Glu Trp Ser Tyr Ile Val Glu Lys Ile 50 55 60Asn Pro Ala Asn Asp
Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu65 70 75 80Glu Leu Lys
His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 85 90 95Ile Ile
Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val 100 105
110Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe Arg Asn Val
115 120 125Val Trp Leu Ile Lys Lys Asp Asn Ala Tyr Pro Thr Ile Lys
Arg Ser 130 135 140Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu
Trp Gly Ile His145 150 155 160His Pro Asn Asp Ala Ala Glu Gln Thr
Arg Leu Tyr Gln Asn Pro Thr 165 170 175Thr Tyr Ile Ser Val Gly Thr
Ser Thr Leu Asn Gln Arg Leu Val Pro 180 185 190Lys Ile Ala Thr Arg
Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 195 200 205Phe Phe Trp
Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 210 215 220Asn
Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile Val Lys Lys225 230
235 240Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys
Asn 245 250 255Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser
Met Pro Phe 260 265 270His Asn Ile His Pro Leu Thr Ile Gly Glu Cys
Pro Lys Tyr Val Lys 275 280 285Ser Asn Arg Leu Val Leu Ala Thr Gly
Leu Arg Asn Ser Pro Gln Gly 290 295 300Glu Arg Arg Arg Lys Lys Arg
Gly Leu Phe Gly Ala Ile Ala Gly Phe305 310 315 320Ile Glu Gly Gly
Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His 325 330 335His Ser
Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr 340 345
350Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp
355 360 365Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn
Asn Leu 370 375 380Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu
Asp Gly Phe Leu385 390 395 400Asp Val Trp Thr Tyr Asn Ala Glu Leu
Leu Val Leu Met Glu Asn Glu 405 410 415Arg Thr Leu Asp Phe His Asp
Ser Asn Val Lys Asn Leu Tyr Asp Lys 420 425 430Val Arg Leu Gln Leu
Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys 435 440 445Phe Glu Phe
Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser Val Arg 450 455 460Asn
Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys465 470
475 480Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr
Gln 485 490 495Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala
Leu Ala Ile 500 505 510Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser
Asn Gly Ser Leu Gln 515 520 525Cys Arg Ile Cys Ile
53030565PRTInfluenza A virus 30Met Glu Lys Ile Val Leu Leu Phe Ala
Ile Val Ser Leu Val Lys Ser1 5 10 15Asp Gln Ile Cys Ile Gly Tyr His
Ala Asn Asn Ser Thr Glu Gln Val 20 25 30Asp Thr Ile Met Glu Lys Asn
Val Thr Val Thr His Ala Gln Asp Ile 35 40 45Leu Glu Lys Lys His Asn
Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 50 55 60Pro Leu Ile Leu Arg
Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn65 70 75 80Pro Met Cys
Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 85 90 95Glu Lys
Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 100 105
110Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu
115 120 125Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu
Ala Ser 130 135 140Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys
Ser Ser Phe Phe145 150 155 160Arg Asn Val Val Trp Leu Ile Lys Lys
Asn Ser Thr Tyr Pro Thr Ile 165 170 175Lys Arg Ser Tyr Asn Asn Thr
Asn Gln Glu Asp Leu Leu Val Leu Trp 180 185 190Gly Ile His His Pro
Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 195 200 205Asn Pro Thr
Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 210 215 220Leu
Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly225 230
235 240Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile
Asn 245 250 255Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala
Tyr Lys Ile 260 265 270Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser
Glu Leu Glu Tyr Gly 275 280 285Asn Cys Asn Thr Lys Cys Gln Thr Pro
Met Gly Ala Ile Asn Ser Ser 290 295 300Met Pro Phe His Asn Ile His
Pro Leu Thr Ile Gly Glu Cys Pro Lys305 310 315 320Tyr Val Lys Ser
Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 325 330 335Pro Gln
Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 340 345
350Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr
355 360 365Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala
Asp Lys 370 375 380Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn
Lys Val Asn Ser385 390 395 400Ile Ile Asp Lys Met Asn Thr Gln Phe
Glu Ala Val Gly Arg Glu Phe 405 410 415Asn Asn Leu Glu Arg Arg Ile
Glu Asn Leu Asn Lys Lys Met Glu Asp 420 425 430Gly Phe Leu Asp Val
Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 435 440 445Glu Asn Glu
Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 450 455 460Tyr
Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly465 470
475 480Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met
Glu 485 490 495Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser
Glu Glu Ala 500 505 510Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys
Leu Glu Ser Ile Gly 515 520 525Ile Tyr Gln Ile Leu Ser Ile Tyr Ser
Thr Val Ala Ser Ser Leu Ala 530 535 540Leu Ala Ile Met Val Ala Gly
Leu Ser Leu Trp Met Cys Ser Asn Gly545 550 555 560Ser Leu Gln Cys
Arg 56531122PRTHomo sapiens 31Gln Val Gln Leu Gln Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Pro Phe Ser Ser Tyr 20 25 30Val Met Ile Trp Val Arg Gln
Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Ser Ala Ile Gly Gly Ser
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr65 70 75 80Leu Gln Met
Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Val Leu
Ser Pro Lys Ser Tyr Tyr Asp Asn Ser Gly Ile Tyr Phe Asp 100 105
110Phe Trp Gly Lys Gly Thr Leu Val Arg Val 115 1203298PRTHomo
sapiens 32Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
Ser Ser Tyr 20 25 30Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40
45Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Ala Lys33108PRTHomo sapiens 33Leu Pro Glu Leu
Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys1 5 10 15Thr Ala Arg
Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30Tyr Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45Glu
Asp Ser Asp Arg Pro Ser Gly Leu Pro Glu Arg Phe Ser Gly Ser 50 55
60Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly65
70 75 80Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp
His 85 90 95Trp Val Phe Gly Gly Arg Thr Lys Leu Thr Val Leu 100
1053496PRTHomo sapiens 34Ser Tyr Val Leu Thr Gln Pro Pro Ser Val
Ser Val Ala Pro Gly Lys1 5 10 15Thr Ala Arg Ile Thr Cys Gly Gly Asn
Asn Ile Gly Ser Lys Ser Val 20 25 30His Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Tyr Asp Ser Asp Arg Pro Ser
Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60Asn Ser Gly Asn Thr Ala
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly65 70 75 80Asp Glu Ala Asp
Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90
9535111PRTHomo sapiens 35Gln Ala Val Leu Thr Gln Pro Pro Ser Ala
Ser Gly Thr Pro Gly Gln1 5 10 15Arg Val Thr Ile Ser Cys Ser Gly Ser
Ser Ser Asn Ile Gly Ser Tyr 20 25 30Thr Val Asn Trp Tyr Gln Gln Leu
Pro Gly Ser Ala Pro Lys Leu Leu 35 40 45Ile Tyr Ser Asn Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60Gly Ser Lys Ser Gly Thr
Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln65 70 75 80Ser Glu Asp Glu
Ala Asp Tyr Tyr Cys Ala Ala Trp Ala Asp Arg Gln 85 90 95Asn Gly Trp
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
1103698PRTHomo sapiens 36Gln Ser Val Leu Thr Gln Pro Pro Ser Ala
Ser Gly Thr Pro Gly Gln1 5 10 15Arg Val Thr Ile Ser Cys Ser Gly Ser
Ser Ser Asn Ile Gly Ser Asn 20 25 30Thr Val Asn Trp Tyr Gln Gln Leu
Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45Ile Tyr Ser Asn Asn Gln Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60Gly Ser Lys Ser Gly Thr
Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln65 70 75 80Ser Glu Asp Glu
Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95Asn Gly
37122PRTHomo sapiens 37Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Pro Phe Ser Ser Tyr 20 25 30Val Met Ile Trp Val Arg Gln Val Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45Ser Ala Ile Gly Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Ser Lys Asn Thr Leu Tyr65 70 75 80Leu Gln Met Asn Ser
Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Val Leu Ser Pro
Lys Ser Tyr Tyr Asp Asn Ser Gly Ile Tyr Phe Asp 100 105 110Phe Trp
Gly Gln Gly Thr Leu Val Arg Val 115 12038112PRTHomo sapiens 38Asn
Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys1 5 10
15Thr Ile Thr Ile Ser Cys Thr Ala Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile
Val 35 40 45Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser 50 55 60Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly65 70 75 80Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys
Gln Ser Tyr Asp Asn 85 90 95Thr Asn His Trp Val Phe Gly Gly Gly Thr
Lys Val Thr Val Leu Gly 100 105 1103998PRTHomo sapiens 39Asn Phe
Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys1 5 10 15Thr
Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25
30Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
35 40 45Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser 50 55 60Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly65 70 75 80Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95Ser Asn 40122PRTHomo sapiens 40Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly1 5 10 15Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Tyr 20 25 30Val
Met Ile Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40
45Ser Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
Tyr65 70 75 80Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Val Leu Ser Pro Lys Ser Tyr Tyr Asp Asn Ser Gly
Ile Tyr Phe Asp 100 105 110Phe Trp Gly Arg Gly Thr Leu Val Arg Val
115 12041112PRTHomo sapiens 41Gln Ser Val Leu Thr Gln Pro Pro Ser
Val Ser Gly Ala Pro Gly Gln1 5 10 15Arg Val Thr Ile Ser Cys Thr Gly
Ser Ser Ser Asn Thr Gly Ala Gly 20 25 30Asn His Val His Trp Tyr Gln
Gln Val Ala Gly Ala Ala Pro Lys Leu 35 40 45Leu Ile Ser Asn Asn Asn
Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60Ser Ala Ser Lys Ser
Gly Thr Ser Ala Ser Leu Asp Ile Thr Gly Leu65 70 75 80Gln Ala Glu
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 85 90 95Leu Asn
Asp Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
1104299PRTHomo sapiens 42Gln Ser Val Leu Thr Gln Pro Pro Ser Val
Ser Gly Ala Pro Gly Gln1 5 10 15Arg Val Thr Ile Ser Cys Thr Gly Ser
Ser Ser Asn Ile Gly Ala Gly 20 25 30Tyr Asp Val His Trp Tyr Gln Gln
Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45Leu Ile Tyr Gly Asn Ser Asn
Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60Ser Gly Ser Lys Ser Gly
Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu65 70 75 80Gln Ala Glu Asp
Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95Leu Ser Gly
43121PRTHomo sapiens 43Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Thr Leu Ser Thr Tyr 20 25 30Gly Met His Trp Val Arg Gln Ala Ala
Gly Lys Gly Leu Glu Trp Val 35 40 45Ala Val Ser Ser Tyr Asp Gly Arg
Asn Glu Tyr Tyr Ala Asp Ser Val 50 55 60Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Phe Lys Asp Thr Leu Tyr65 70 75 80Leu Gln Met Asn Asn
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Lys Glu Val
Gly Met Arg Ser Tyr Asp Ser Tyr Gly Met Asp Val 100 105 110Trp Gly
Lys Gly Thr Leu Val Arg Val 115 1204498PRTHomo sapiens 44Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg1 5 10 15Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser
Val 50 55 60Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr65 70 75 80Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Ala Lys 45108PRTHomo sapiens 45Asp Ile Gln
Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly1 5 10 15Gly Arg
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Pro Trp 20 25 30Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 35 40
45Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Gln
Pro65 70 75 80Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser
Tyr Pro Trp 85 90 95Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
100 1054695PRTHomo sapiens 46Asp Ile Gln Met Thr Gln Ser Pro Ser
Thr Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asp Ala Ser Ser Leu
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr
Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Asp Asp Phe
Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 85 90
9547121PRTHomo sapiens 47Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Val Val Gln Pro Gly Arg1 5 10 15Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Ser Tyr 20 25 30Gly Met His Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Ala His Ile Ser Tyr Asp Gly
Thr Glu Thr His Tyr Thr Asp Ser Val 50 55 60Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Met Glu Thr Ala Tyr65 70 75 80Leu Gln Met Asp
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Lys Asp
Val Ser Leu Arg Ala Tyr Asp His Tyr Gly Met Asp Val 100 105 110Trp
Gly Arg Gly Thr Leu Val Arg Val 115 12048109PRTHomo sapiens 48Ser
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10
15Thr Val Arg Ile Thr Cys Gln Gly Glu Ser Leu Arg Asn Tyr Tyr Ala
20 25 30Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile
Tyr 35 40 45Gly Gly Asn Ser Arg Pro Ser Gly Ile Ala Asp Arg Phe Ser
Gly Ser 50 55 60Ser Ser Gly Ile Thr Ala Ser Leu Thr Ile Thr Gly Ala
Gln Ala Glu65 70 75 80Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Arg Asp
Ser Ser Asp Asn His 85 90 95Arg Val Phe Gly Gly Arg Thr Gln Leu Thr
Val Leu Ser 100 1054996PRTHomo sapiens 49Ser Ser Glu Leu Thr Gln
Asp Pro Ala Val Ser Val Ala Leu Gly Gln1 5 10 15Thr Val Arg Ile Thr
Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 20 25 30Ser Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45Gly Lys Asn
Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60Ser Ser
Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu65 70 75
80Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
85 90 9550121PRTHomo sapiens 50Gln Val Gln Leu Val Gln Ser Gly Gly
Gly Val Val Gln Pro Gly Arg1 5 10 15Ser Leu Arg Leu Ser Cys Gly Ala
Ser Gly Phe Thr Leu Ser Thr Tyr 20 25 30Gly Met His Trp Val Arg Gln
Ala Ala Gly Lys Gly Leu Glu Trp Val 35 40 45Ala Val Ser Ser Tyr Asp
Gly Arg Asn Glu Tyr Tyr Ala Asp Ser Val 50 55 60Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Phe Lys Asp Thr Leu Tyr65 70 75 80Leu Gln Met
Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Lys
Glu Val Gly Met Arg Ser Tyr Asp Ser Tyr Gly Met Asp Val 100 105
110Trp Gly Arg Gly Thr Leu Val Arg Val 115 12051108PRTHomo sapiens
51Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn
Trp 20 25 30Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Val
Leu Ile 35 40 45Phe Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser
Ser Leu Gln Ala65 70 75 80Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
Ser Asn Asn Phe Pro Tyr 85 90 95Thr Phe Gly Gln Gly Thr Lys Leu Glu
Ile Lys Arg 100 1055295PRTHomo sapiens 52Asp Ile Gln Met Thr Gln
Ser Pro Ser Ser Val Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile
Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45Tyr Ala Ala
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75
80Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 85 90
9553121PRTHomo sapiens 53Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Val Val Gln Pro Gly Arg1 5 10 15Thr Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Thr Ser Tyr 20 25 30Gly Met His Trp Val Arg Gln Ala
Pro Gly Lys Gly Leu Glu Trp Val 35 40 45Ala Val Ile Ser Tyr Asp Gly
Arg Lys Lys Tyr Tyr Leu Asp Ser Val 50 55 60Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Met Glu Thr Ala Tyr65 70 75 80Leu Gln Met Asp
Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Lys Asp
Val Ser Leu Arg Ala Tyr Asp His Tyr Gly Met Asp Val 100 105 110Trp
Gly Gln Gly Thr Leu Val Arg Val 115 12054108PRTHomo sapiens 54Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu
Ile 35 40 45Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro65 70 75 80Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser
Tyr Ser Thr Pro Phe 85 90 95Thr Phe Gly Gly Gly Thr Lys
Val Asp Ile Lys Arg 100 1055595PRTHomo sapiens 55Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45Tyr
Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55
60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65
70 75 80Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro
85 90 9556270PRTHomo sapiens 56Met Ala Gln Val Gln Leu Gln Gln Ser
Gly Pro Gly Leu Val Lys Pro1 5 10 15Ser Glu Thr Leu Ser Leu Thr Cys
Ser Val Ser Gly Asp Ser Ile Lys 20 25 30Ser Arg Arg Tyr Tyr Trp Ala
Trp Ile Arg Gln Pro Pro Gly Lys Gly 35 40 45Met Glu Phe Ile Gly Arg
Leu Ser His Asp Gly Ser Thr Tyr Tyr Thr 50 55 60Pro Ser Leu Lys Ser
Arg Leu Thr Ile Ser Pro Asp Thr Ser Lys Asn65 70 75 80Gln Phe Ser
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met 85 90 95Tyr Tyr
Cys Ala Arg Gly Val Tyr Asp Trp Gly Asn Ser Tyr Gln Leu 100 105
110Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
115 120 125Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Asp 130 135 140Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Thr
Ser Val Gly Asp145 150 155 160Arg Val Thr Ile Thr Cys Arg Ala Ser
Gln Asn Ile Ser Asn Trp Leu 165 170 175Ala Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 180 185 190Lys Ala Ser Ser Leu
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 195 200 205Gly Ser Gly
Thr Glu Phe Thr Leu Thr Ile Ala Ser Leu Gln Pro Asp 210 215 220Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Arg Ser Trp Thr Phe225 230
235 240Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala His His
His 245 250 255His His His Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp
Leu 260 265 27057270PRTHomo sapiensMOD_RES(267)..(267)Any amino
acid 57Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
Pro1 5 10 15Gly Glu Ser Leu Lys Ile Ser Cys Lys Ser Ser Gly Tyr Lys
Leu Ser 20 25 30Ser Tyr Trp Ile Ala Trp Val Arg Gln Val Pro Gly Lys
Gly Leu Glu 35 40 45Trp Val Gly Ile Ile Asp Pro Arg Asp Ser Asp Thr
Arg Tyr Ser Pro 50 55 60Ser Phe Glu Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Asn Thr65 70 75 80Ala Tyr Leu Gln Trp Ser Ser Leu Lys
Thr Ala Asp Thr Ala Met Tyr 85 90 95Phe Cys Ala Arg Gln Ala Asp Gly
Tyr Arg Ser Phe Tyr Gly Met Asp 100 105 110Val Trp Gly Arg Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Asp Ile 130 135 140Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg145 150 155
160Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr Leu Asn
165 170 175Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
Tyr Ala 180 185 190Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly Ser Gly 195 200 205Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro Glu Asp 210 215 220His Ala Ser Tyr Tyr Cys Gln Gln
Ser Tyr Ser Thr Pro Val Thr Phe225 230 235 240Gly Gln Gly Thr Arg
Leu Glu Ile Lys Arg Ala Ala Ala His His His 245 250 255His His His
Gly Glu Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 265 27058273PRTHomo
sapiensMOD_RES(273)..(273)Any amino acid 58Met Ala Gln Met Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro1 5 10 15Gly Ser Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn 20 25 30Lys Tyr Ile Ile
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 35 40 45Trp Val Gly
Arg Ile Val Pro Ile Thr Gly Ile Thr Asn Tyr Ala Gln 50 55 60Arg Leu
Gln Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Asn Thr65 70 75
80Ala Tyr Met Glu Leu Arg Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Asp Gln Gly Asp Leu Trp Pro His Gln Tyr Gln
Gly 100 105 110Thr Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
Ser Gly Gly 115 120 125Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ser Ala Glu 130 135 140Ile Val Leu Thr Gln Ser Pro Leu Ser
Leu Pro Val Thr Pro Gly Glu145 150 155 160Pro Ala Ser Ile Ser Cys
Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn 165 170 175Gly Tyr Asn Tyr
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 180 185 190Gln Leu
Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp 195 200
205Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser
210 215 220Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln
Ala Leu225 230 235 240Gln Val Pro His Thr Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys Arg 245 250 255Ala Ala Ala His His His His His His
Gly Glu Gln Lys Ile Asp Leu 260 265 270Xaa 59269PRTHomo sapiens
59Met Ala Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Pro1
5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Ile Phe
Lys 20 25 30Thr Tyr Asp Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly
Leu Glu 35 40 45Trp Val Ala Phe Ile Arg His Asp Gly Arg Asp Ile Lys
Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
Ser Lys Asp Thr65 70 75 80Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Phe Cys Ala Arg Asn Arg Phe Thr Gly
Tyr Asn Tyr Phe Glu His Trp 100 105 110Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser Ala Leu Glu Ile Val Met 130 135 140Thr Gln Ser
Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr145 150 155
160Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Arg Tyr Leu Ala Trp
165 170 175Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Gly Val 180 185 190Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
Gly Ser Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
Leu Glu Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr
Ala Ala Ser Pro Glu Thr Phe Gly225 230 235 240Gln Gly Thr Lys Val
Glu Ile Lys Arg Ala Ala Ala His His His His 245 250 255His His Gly
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 260 26560269PRTHomo
sapiensMOD_RES(266)..(266)Any amino acid 60Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Ala Gln Pro1 5 10 15Gly Gly Ser Leu Arg
Leu Ser Cys Ser Ala Ser Gly Phe Ser Phe Lys 20 25 30Thr Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 35 40 45Trp Ile Ser
Lys Ile Asp Tyr Gly Asn Arg Thr Thr Asp Tyr Ala Asp 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser65 70 75
80Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Thr Arg Phe Ser Gly Tyr Asp Tyr Phe Glu Asp
Trp 100 105 110Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Leu 130 135 140Thr Gln Ser Pro Gly Thr Leu Ser Leu
Ser Pro Gly Glu Ser Ala Thr145 150 155 160Leu Ser Cys Arg Pro Ser
Gln Ser Val Ser Ser Arg Asp Leu Ala Trp 165 170 175Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 180 185 190Ser Ser
Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200
205Gly Thr Glu Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe
210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Leu Thr
Phe Gly225 230 235 240Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Xaa Glu Asp Leu 260 26561266PRTHomo sapiensMOD_RES(263)..(263)Any
amino acid 61Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val
Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg Arg Ala Pro
Gly Lys Gly Leu Glu 35 40 45Trp Val Ala His Ile Arg Phe Asp Gly Ser
Lys Thr Ser Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu Phe Leu Gln Met Asn Ser
Leu Arg Gly Glu Asp Thr Ala Ile Tyr 85 90 95Tyr Cys Ala Arg Val Arg
Phe Ser Gly Tyr Asp Tyr Phe Glu Asn Trp 100 105 110Gly Lys Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly
Gly Ser Gly Gly Gly Gly Ser Val His Leu Lys Leu Thr Gln 130 135
140Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Ser Ala Thr Leu
Ser145 150 155 160Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala
Trp Tyr Gln Gln 165 170 175Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
Tyr Gly Ala Ser Ser Arg 180 185 190Ala Thr Gly Ile Pro Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205Phe Thr Leu Thr Ile Ser
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220Tyr Cys Gln Gln
Tyr Gly Ser Ser Pro Val Thr Phe Gly Gln Gly Thr225 230 235 240Lys
Leu Glu Ile Lys Arg Ala Ala Ala His His His His His His Gly 245 250
255Glu Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 26562269PRTHomo
sapiensMOD_RES(266)..(267)Any amino acid 62Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Val Val Gln Ser1 5 10 15Gly Gly Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 20 25 30Gly Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala
Gly Leu Arg Tyr Asp Gly Thr Lys Arg Glu Tyr Ala Asp 50 55 60Ser Val
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr
85 90 95Phe Cys Ala Arg Val Arg Phe Ser Gly Tyr Asn Tyr Phe Glu Asn
Trp 100 105 110Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Gly Thr Leu Ser Leu
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Arg Tyr Leu Ala Trp 165 170 175Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Val 180 185 190Ser Ser
Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200
205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe
210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ala Ser Pro Glu Thr
Phe Gly225 230 235 240Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Xaa Xaa Asn Leu 260 26563269PRTHomo sapiens 63Met Ala Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro1 5 10 15Gly Gly Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30Thr Tyr Asp
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val
Ala Gly Leu Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp 50 55 60Ser
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Glu Tyr Phe Glu Asn
Trp 100 105 110Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Asp Val Val Met 130 135 140Thr Gln Ser Pro Ser Thr Leu Ser Ala
Ser Val Gly Asp Arg Val Thr145 150 155 160Ile Thr Cys Arg Ala Ser
Gln Ser Val Ser Thr Trp Leu Ala Trp Tyr 165 170 175Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Ala Ser 180 185 190Asn Leu
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Asp 195 200
205Thr Glu Phe Thr Leu Thr Ile Asn Asn Leu Gln Pro Ala Asp Phe Ala
210 215 220Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Ser Ala Thr
Phe Gly225 230 235 240Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Glu Glu Asp Leu 260 26564270PRTHomo sapiensMOD_RES(267)..(267)Any
amino acid 64Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val
Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu 35 40 45Trp Val Ala His Ile Arg Phe Asp Gly Ser
Lys Thr Ser Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu Phe Leu Gln Met Asn Ser
Leu Arg Gly Glu Asp Thr Ala Ile Tyr 85 90 95Tyr Cys Ala Arg Val Arg
Phe Ser Gly Tyr Asp Tyr Phe Glu Asn Trp 100 105 110Gly Gln Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Glu Ile Val Leu 130 135
140Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
Thr145 150 155 160Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
Tyr Leu Ala Trp
165 170 175Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Gly Ala 180 185 190Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
Gly Ser Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
Leu Glu Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr
Gly Ser Ser Pro Pro Tyr Thr Phe225 230 235 240Gly Gln Gly Thr Lys
Leu Glu Ile Lys Arg Ala Ala Ala His His His 245 250 255His His His
Gly Glu Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 265 27065268PRTHomo
sapiensMOD_RES(265)..(265)Any amino acid 65Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Asn Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 20 25 30Thr Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala
Gly Val Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Thr Glu 50 55 60Ser Val
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Phe Leu Gln Met Asp Ser Leu Arg Gly Asp Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Asp Tyr Phe Glu Asn
Trp 100 105 110Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Ala Thr Leu Ser Val
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr 165 170 175Gln Gln Lys Pro
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 180 185 190Thr Arg
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 195 200
205Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Phe Ala
210 215 220Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Leu Thr Phe
Gly Gly225 230 235 240Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala
His His His His His 245 250 255His Gly Glu Gln Lys Leu Ile Ser Xaa
Glu Asp Leu 260 26566269PRTHomo sapiensMOD_RES(267)..(267)Any amino
acid 66Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser
Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Lys
Gly Leu Glu 35 40 45Trp Val Ala Gly Leu Arg Tyr Asp Gly Ser Lys Lys
Tyr Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Thr Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asp Ser Leu Arg
Gly Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Val Arg Phe Ser
Gly Tyr Glu Tyr Phe Glu Asn Trp 100 105 110Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ser Ala Leu Glu Ile Val Met 130 135 140Thr Gln
Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr145 150 155
160Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp
165 170 175Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Gly Ala 180 185 190Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
Gly Ser Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
Leu Glu Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr
Gly Ser Ser Pro Phe Thr Phe Gly225 230 235 240Gly Gly Thr Lys Val
Glu Ile Lys Arg Ala Ala Ala His His His His 245 250 255His His Gly
Glu Gln Lys Leu Ile Ser Glu Xaa Asp Leu 260 26567269PRTHomo
sapiensMOD_RES(266)..(266)Any amino acid 67Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala
Gly Leu Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Glu Tyr Phe Glu Asn
Trp 100 105 110Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Leu 130 135 140Thr Gln Ser Pro Gly Thr Leu Ser Leu
Ser Pro Gly Glu Arg Val Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Thr Tyr Leu Ala Trp 165 170 175Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 180 185 190Ser Ser
Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200
205Gly Thr Asp Phe Thr Leu Thr Val Thr Arg Leu Glu Pro Glu Asp Phe
210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ser Pro Leu Thr
Phe Gly225 230 235 240Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Xaa Glu Asp Leu 260 26568269PRTHomo sapiens 68Met Ala Glu Val Gln
Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 20 25 30Thr Tyr Asp
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val
Ala Gly Ile Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp 50 55 60Ser
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Glu Tyr Phe Glu Asn
Trp 100 105 110Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Ser Thr Leu Ser Leu
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp 165 170 175Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 180 185 190Ser Ser
Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200
205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe
210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ser Tyr Thr
Phe Gly225 230 235 240Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Glu Glu Asp Leu 260 26569269PRTHomo sapiens 69Met Ala Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Asn Pro1 5 10 15Gly Gly Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30Thr Tyr Asp
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val
Ala His Ile Arg Phe Asp Gly Ser Lys Thr Ser Tyr Ala Asp 50 55 60Ser
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Phe Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Asp Tyr Phe Glu Asn
Trp 100 105 110Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Gly Thr Leu Ser Leu
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp 165 170 175Tyr Gln Gln Lys
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 180 185 190Ser Ser
Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200
205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe
210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gly Thr
Phe Gly225 230 235 240Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Glu Glu Asp Leu 260 26570270PRTHomo sapiensMOD_RES(267)..(267)Any
amino acid 70Leu Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val
Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu 35 40 45Trp Val Ala His Ile Arg Phe Asp Gly Ser
Lys Thr Ser Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu Phe Leu Gln Met Asn Ser
Leu Arg Ala Glu Asp Thr Ala Ile Tyr 85 90 95Tyr Cys Ala Arg Val Arg
Phe Ser Gly Tyr Asp Tyr Phe Glu Asn Trp 100 105 110Gly Lys Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Glu Ile Val Leu 130 135
140Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
Thr145 150 155 160Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
Tyr Leu Ala Trp 165 170 175Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
Leu Leu Ile Tyr Gly Ala 180 185 190Ser Ser Arg Ala Thr Gly Ile Pro
Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu
Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr
Cys Gln Gln Tyr Gly Ser Ser Leu Ala Leu Thr Phe225 230 235 240Gly
Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala His His His 245 250
255His His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 265
27071268PRTHomo sapiens 71Met Ala Gln Val Gln Leu Val Glu Ser Gly
Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala His Ile Arg Phe
Asp Gly Ser Lys Thr Ser Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu Phe Leu Gln
Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr 85 90 95Tyr Cys Ala
Arg Val Arg Phe Ser Gly Tyr Asp Tyr Phe Glu Asn Trp 100 105 110Gly
Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120
125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Asp Ile Gln Leu
130 135 140Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg
Val Thr145 150 155 160Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser
Gly Leu Ala Trp Tyr 165 170 175Gln Gln Asn Pro Gly Lys Ala Pro Asn
Leu Leu Ile Tyr Ala Ala Ser 180 185 190Asn Leu Gln Ser Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly 195 200 205Thr Asp Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 210 215 220Thr Tyr Tyr
Cys Gln Gln Thr Asn Ser Phe Pro Leu Thr Phe Gly Gly225 230 235
240Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His
245 250 255His Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 260
26572269PRTHomo sapiensMOD_RES(266)..(266)Any amino acid 72Met Ala
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly
Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25
30Thr Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45Trp Val Ala His Ile Arg Phe Asp Gly Ser Lys Thr Ser Tyr Ala
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys
Asn Thr65 70 75 80Leu Phe Leu Gln Met Asn Ser Leu Arg Gly Glu Asp
Thr Ala Ile Tyr 85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Asp
Tyr Phe Glu Asn Trp 100 105 110Gly Arg Gly Thr Leu Val Thr Val Ser
Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ser Ala Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Gly
Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser
Cys Arg Ala Ser Gln Ser Val Ser Ser Arg Tyr Leu Ala Trp 165 170
175Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Val
180 185 190Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser
Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ala
Ser Pro Glu Thr Phe Gly225 230 235 240Gln Gly Thr Lys Val Glu Ile
Lys Arg Ala Ala Ala His His His His 245 250 255His His Gly Glu Gln
Lys Leu Ile Ser Xaa Glu Asp Leu 260 26573269PRTHomo
sapiensMOD_RES(266)..(266)Any amino acid 73Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 20 25 30Thr Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala
Gly Ile Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Glu Tyr Phe Glu Asn
Trp 100 105 110Gly Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Gly Thr Leu Ser Leu
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Arg Tyr Leu Ala Trp 165
170 175Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly
Val 180 185 190Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
Ser Gly Ser 195 200 205Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
Glu Pro Glu Asp Phe 210 215 220Ala Val Tyr Tyr Cys Gln Gln Tyr Ala
Ala Ser Pro Glu Thr Phe Gly225 230 235 240Gln Gly Thr Lys Val Glu
Ile Lys Arg Ala Ala Ala His His His His 245 250 255His His Gly Glu
Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 26574269PRTHomo
sapiensMOD_RES(269)..(269)Any amino acid 74Met Ala Gln Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro1 5 10 15Gly Gly Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Pro 20 25 30Thr Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val Ala
His Ile Arg Phe Asp Gly Thr Lys Thr Ser Tyr Gly Asp 50 55 60Ala Val
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asn Arg Leu Arg Gly Glu Asp Thr Ala Ile Tyr
85 90 95Tyr Cys Ala Arg Val Arg Phe Ser Gly Tyr Asp Tyr Phe Glu Asn
Trp 100 105 110Gly Arg Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Glu Ile Val Met 130 135 140Thr Gln Ser Pro Ala Thr Leu Ser Val
Ser Pro Gly Glu Arg Ala Thr145 150 155 160Leu Ser Cys Arg Ala Ser
Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr 165 170 175Gln Gln Lys Pro
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 180 185 190Thr Arg
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 195 200
205Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Phe Ala
210 215 220Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Leu Thr Phe
Gly Gly225 230 235 240Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala
His His His His His 245 250 255His Gly Glu Gln Lys Leu Ile Ser Glu
Glu Asp Leu Xaa 260 26575271PRTHomo sapiensMOD_RES(268)..(268)Any
amino acid 75Met Ala Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val
Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
Phe Ser Phe Ser 20 25 30Thr Tyr Asp Met His Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu 35 40 45Trp Val Ala Gly Leu Arg Tyr Asp Gly Ser
Lys Lys Tyr Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Thr Lys Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asp Ser
Leu Arg Gly Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Val Arg
Phe Ser Gly Tyr Glu Tyr Phe Glu Asn Trp 100 105 110Gly Lys Gly Thr
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Ala Gln Ser Ala Leu Thr 130 135
140Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile
Ser145 150 155 160Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn
Tyr Val Ser Trp 165 170 175Tyr Gln Gln His Pro Gly Lys Ala Pro Lys
Leu Met Ile Tyr Asp Val 180 185 190Ser Asn Arg Pro Ser Gly Val Ser
Asn Arg Phe Ser Gly Ser Lys Ser 195 200 205Gly Asn Thr Ala Ser Leu
Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 210 215 220Ala Asp Tyr Tyr
Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val Ile225 230 235 240Phe
Gly Gly Arg Thr Lys Leu Thr Val Leu Gly Ala Ala Ala His His 245 250
255His His His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu Asn Cys 260
265 27076277PRTHomo sapiensMOD_RES(269)..(269)Any amino acid 76Met
Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro1 5 10
15Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Leu Ser
20 25 30Ile Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu 35 40 45Trp Met Gly Arg Ile Ile Pro Ile Thr Gly Val Pro Asn Tyr
Ser Gln 50 55 60Asn Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser
Thr Ser Thr65 70 75 80Thr Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Leu Ser Gly Ala Gly Tyr Asn
Tyr Tyr Gly Met Asp Val 100 105 110Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Gly
Gly Gly Ala Leu Glu Ile Val Leu Thr Gln 130 135 140Ser Pro Leu Ser
Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser145 150 155 160Cys
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu 165 170
175Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr
180 185 190Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
Gly Ser 195 200 205Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg
Val Glu Ala Glu 210 215 220Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
Leu Gln Thr Pro Leu Thr225 230 235 240Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys Arg Ala Ala Ala His His 245 250 255His His His His Gly
Glu Gln Lys Leu Ile Ser Glu Xaa Asn Cys Lys 260 265 270Leu Leu Lys
Val Val 27577275PRTHomo sapiensMOD_RES(271)..(272)Any amino acid
77Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro1
5 10 15Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Leu
Ser 20 25 30Ile Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu 35 40 45Trp Met Gly Arg Ile Ile Pro Ile Thr Gly Val Pro Asn
Tyr Ser Gln 50 55 60Asn Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys
Ser Thr Ser Thr65 70 75 80Thr Tyr Met Glu Leu Ser Ser Leu Arg Ser
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Leu Ser Gly Ala Gly Tyr
Asn Tyr Tyr Gly Met Asp Val 100 105 110Trp Gly Lys Gly Thr Leu Val
Thr Val Ser Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Ser Ala Leu Glu Ile Val 130 135 140Leu Thr Gln
Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala145 150 155
160Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr
165 170 175Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro
His Leu 180 185 190Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val
Pro Asp Arg Phe 195 200 205Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile Ser Arg Val 210 215 220Glu Ala Glu Asp Val Gly Val Tyr
Tyr Cys Met Gln Ala Leu Gln Thr225 230 235 240Pro Arg Thr Phe Gly
Pro Gly Thr Lys Val Glu Ile Lys Arg Ala Ala 245 250 255Ala His His
His His His His Gly Glu Gln Lys Leu Ile Ser Xaa Xaa 260 265 270Asp
Leu Xaa 27578271PRTHomo sapiensMOD_RES(268)..(268)Any amino acid
78Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro1
5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Leu
Ser 20 25 30Thr Tyr Gly Met His Trp Val Arg Gln Ala Ala Gly Lys Gly
Leu Glu 35 40 45Trp Val Ala Val Ser Ser Tyr Asp Gly Arg Asn Glu Tyr
Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Phe Lys Asp Thr65 70 75 80Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala
Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Lys Glu Val Gly Met Arg
Ser Tyr Asp Ser Tyr Gly Met 100 105 110Asp Val Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Gly Gly Gly 115 120 125Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Asp 130 135 140Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp145 150 155
160Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
165 170 175Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile Tyr 180 185 190Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
Phe Ser Gly Ser 195 200 205Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu 210 215 220Asp Phe Ala Thr Tyr Tyr Cys Gln
Gln Ser Tyr Ser Thr Pro Tyr Thr225 230 235 240Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Arg Ala Ala Ala His His 245 250 255His His His
His Gly Glu Gln Lys Leu Ile Ser Xaa Glu Asp Leu 260 265
27079267PRTHomo sapiensMOD_RES(223)..(223)Any amino acid 79Met Ala
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro1 5 10 15Gly
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser 20 25
30Asn Tyr His Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45Trp Val Ser His Ile Ser Ser Ser Ser Arg Thr Ile Lys Tyr Ala
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Ala Gly Ser Gly Tyr Ser Ser
Gly Pro Thr Asp Tyr 100 105 110Trp Gly Lys Gly Thr Met Val Thr Val
Ser Ser Gly Gly Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ser Ala Gln Ser Val Leu 130 135 140Thr Gln Leu Pro Ser
Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile145 150 155 160Ser Cys
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 165 170
175Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly
180 185 190Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly
Ser Lys 195 200 205Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
Gln Ala Xaa Asp 210 215 220Xaa Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp
Thr Asn Leu Arg Ala Tyr225 230 235 240Val Phe Gly Thr Gly Thr Lys
Leu Thr Val Leu Xaa Ala Ala Ala His 245 250 255His His His His His
Gly Lys Gln Asn Ser Gln 260 26580275PRTHomo sapiens 80Met Ala Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Ser Ser 20 25 30Val
Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 35 40
45Trp Val Ala Leu Ile Ser His Asp Gly Asn His Lys His Tyr Ala Asp
50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Ala65 70 75 80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr
Ala Val Tyr 85 90 95Tyr Cys Ala Arg Asp Arg Phe Gly Arg Ser Gly Ile
Lys Leu Lys Val 100 105 110Thr Tyr Leu Asp Tyr Trp Gly Glu Gly Thr
Thr Val Thr Val Ser Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140Ala Leu Glu Ile Val Leu
Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser145 150 155 160Pro Gly Glu
Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Ile His 165 170 175Arg
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 180 185
190Leu Ile Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe
195 200 205Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu 210 215 220Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
Tyr Asn Ser Trp225 230 235 240Pro Pro Ile Thr Phe Gly Gln Gly Thr
Arg Leu Glu Ile Lys Arg Ala 245 250 255Ala Ala His His His His His
His Gly Glu Gln Lys Leu Ile Ser Glu 260 265 270Glu Asp Leu
27581269PRTHomo sapiensMOD_RES(268)..(268)Any amino acid 81Met Ala
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly
Lys Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 20 25
30Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45Trp Val Ala Phe Ile Ser Tyr Asp Ala Ser Asn Gln Tyr Tyr Ala
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys
Asn Thr65 70 75 80Val Ser Leu Gln Met Ser Ser Leu Lys Thr Asp Asp
Thr Ala Val Tyr 85 90 95Tyr Cys Ala Lys Asp Phe Ser Trp Ser Gly Ser
Ile Asp Ser Trp Gly 100 105 110Gln Gly Thr Leu Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly 115 120 125Gly Gly Ser Gly Gly Gly Gly
Ser Ser Ala Leu Asp Val Val Met Thr 130 135 140Gln Ser Pro Gly Thr
Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu145 150 155 160Ser Cys
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 165 170
175Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser
180 185 190Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly
Ser Gly 195 200 205Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
Glu Asp Phe Ala 210 215 220Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser
Leu Ser Leu Thr Phe Gly225 230 235 240Gly Gly Thr Lys Val Glu Ile
Lys Arg Ala Ala Ala His His His His 245 250 255His His Gly Glu Gln
Lys Leu Ile Ser Glu Glu Xaa Leu 260 26582274PRTHomo
sapiensMOD_RES(271)..(271)Any amino acid 82Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg
Leu Ser Cys Thr Ala Ser Gly Phe Ser Ser Ser 20 25 30Val Tyr Asp Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 35 40 45Trp Val Ala
Leu Ile Ser His Asp Gly Asn His Lys His Tyr Ala Asp 50 55 60Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala65 70 75
80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Arg Asp Arg Phe Gly Arg Ser Gly Ile Lys Leu Lys
Val 100 105 110Thr Tyr Leu Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr
Val Ser Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135
140Ala Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser145 150 155 160Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
Gln Asn Ile Ser 165 170 175Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu 180 185 190Leu Ile Tyr Ala Thr Ser Arg Leu
Gln Ser Gly Val Pro Ser Arg Phe 195 200 205Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 210 215 220Gln Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr225 230 235 240Pro
Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Ala Ala 245 250
255Ala His His His His His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu
260 265 270Asp Leu83274PRTHomo sapiensMOD_RES(271)..(271)Any amino
acid 83Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Ser Ser 20 25 30Pro Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu 35 40 45Trp Val Ala Leu Ile Ser His Asp Gly Ser Tyr Lys
His Tyr Thr Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Ala65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Asp Arg Phe Gly
Arg Ser Gly Ile Lys Leu Lys Val 100 105 110Thr Tyr Leu Asp Tyr Trp
Gly Lys Gly Thr Leu Val Thr Val Ser Ser 115 120 125Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140Ala Leu
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser145 150 155
160Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp
165 170 175Asn Thr Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
Pro Arg 180 185 190Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly
Ile Pro Asp Arg 195 200 205Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Arg 210 215 220Leu Glu Pro Glu Asp Ser Ala Val
Tyr Tyr Cys Gln Gln Tyr Gly Asn225 230 235 240Ser Leu Asn Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 245 250 255Ala His His
His His His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu 260 265 270Asp
Leu84274PRTHomo sapiensMOD_RES(271)..(271)Any amino acid 84Met Ala
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly
Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Ser Ser 20 25
30Val Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
35 40 45Trp Val Ala Leu Ile Ser His Asp Gly Asn His Lys His Tyr Ala
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Ala65 70 75 80Leu Tyr Leu Gln Met Asp Ser Leu Arg Gly Glu Asp
Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Asp Arg Phe Gly Arg Ser Gly
Ile Lys Leu Lys Val 100 105 110Thr Tyr Leu Asp Tyr Trp Gly Arg Gly
Thr Leu Val Thr Val Ser Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140Ala Leu Asp Ile Gln
Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser145 150 155 160Val Gly
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr 165 170
175Asn Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu
180 185 190Leu Ile Tyr Lys Thr Ser Thr Leu Gln Ser Gly Val Pro Ser
Arg Phe 195 200 205Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
Ile Ser Ser Leu 210 215 220Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln Tyr His Arg Phe225 230 235 240Ser Tyr Ser Phe Gly Gln Gly
Thr Lys Val Glu Ile Lys Arg Ala Ala 245 250 255Ala His His His His
His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu 260 265 270Asn
Leu85274PRTHomo sapiensMOD_RES(271)..(271)Any amino acid 85Met Ala
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly
Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser 20 25
30Val Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
35 40 45Trp Val Ala Leu Ile Ser His Asp Gly Asn His Lys His Tyr Thr
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Ala65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Gly Glu Asp
Thr Ala Val Tyr 85 90 95Tyr Cys Ala Arg Asp Arg Phe Gly Arg Ser Gly
Met Lys Leu Lys Val 100 105 110Thr Tyr Leu Asp Tyr Trp Gly Lys Gly
Thr Leu Val Thr Val Ser Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140Ala Leu Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser145 150 155 160Val Gly
Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Ser Ile Asn 165 170
175Ala Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
180 185 190Leu Ile Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser
Arg Phe 195 200 205Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Arg Leu 210 215 220Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln Thr Tyr Ser Ser225 230 235 240Pro Leu Thr Phe Gly Gly Gly
Thr Lys Val Glu Ile Lys Arg Ala Ala 245 250 255Ala His His His His
His His Gly Glu Gln Lys Leu Ile Ser Xaa Glu 260 265 270Asp
Leu86276PRTHomo sapiens 86Met Ala Glu Val Gln Leu Val Glu Thr Gly
Gly Gly Val Val Gln Pro1 5 10 15Gly Arg Ser Leu Arg Leu Ser Cys Thr
Ala Ser Gly Phe Ser Ser Ser 20 25 30Val Tyr Asp Met His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu 35 40 45Trp Val Ala Leu Ile Ser His
Asp Gly Asn His Lys His Tyr Ala Asp 50 55 60Ser Val Lys Gly Arg Phe
Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala65 70 75 80Leu Tyr Leu Gln
Met Asp Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr 85 90 95Tyr Cys Ala
Arg Asp Arg Phe Gly Arg Ser Gly Ile Lys Leu Lys Val 100 105 110Thr
Tyr Leu Asp Tyr Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120
125Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
130 135 140Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala
Pro Gly145 150 155 160Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser
Ser Asn Ile Gly Lys 165 170 175Asn Tyr Val Ser Trp Tyr Gln Gln Val
Pro Gly Thr Ala Pro Lys Leu 180 185 190Leu Ile Tyr Asp Asn Asn Lys
Arg Pro Ser Gly Ile Pro Asp Arg Phe 195 200 205Ser Gly Ser Lys Ser
Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 210 215 220Gln Thr Gly
Asp Glu Ala Asp Tyr His Cys Gly Thr Trp Asp Ser Ser225 230 235
240Leu His Ser Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
245 250 255Ala Ala Ala His His His His His His Gly Glu Gln Lys Leu
Ile Ser 260 265 270Glu Glu Asp Leu 27587269PRTHomo
sapiensMOD_RES(249)..(249)Any amino acid 87Met Ala Glu Val Gln Leu
Val Glu Ser Gly Gly Asp Leu Val Arg Pro1 5 10 15Gly Gly Ser Leu Arg
Leu Ser Cys Thr Ile Ser Gly Val Thr Phe Asn 20 25 30Gln Tyr Ala Ile
Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln 35 40 45Trp Leu Ser
Thr Ile Ala Gly Thr Gly Thr Lys Thr Phe Tyr Ala Asp 50 55 60Ser Val
Lys Gly Arg Phe Thr Met Ser Arg Asp Ser Ser Gly Asn Thr65 70 75
80Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Lys Ser Leu Ser Met Arg Tyr Phe Leu Asp Leu Trp
Gly 100 105 110Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly 115 120 125Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala His
Val Ile Leu Thr Gln 130 135 140Pro Pro Ser Ala Ser Gly Thr Pro Gly
Gln Arg Val Ile Ile Ser Cys145 150 155 160Ser Gly Ser Ser Ser Asn
Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 165 170 175Gln Leu Pro Gly
Thr Ala Pro Lys Leu Leu Ile Tyr Asn Asn Asn Gln 180 185 190Arg Pro
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200
205Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp
210 215 220Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
Phe Gly225 230 235 240Gly Gly Thr Lys Val Thr Val Leu Xaa Ala Ala
Ala His His His His 245 250 255His His Gly Glu Gln Lys Leu Ile Ser
Glu Glu Asp Leu 260 26588271PRTHomo sapiens 88Met Ala Gln Val Gln
Leu Gln Glu Ser Gly Gly Asp Leu Val Lys Pro1 5 10 15Gly Gly Ser Leu
Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Asn 20 25 30Ser Tyr Gly
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 35 40 45Trp Val
Ser Asp Ile Ser Ala Ser Gly Phe Asn Thr Tyr Tyr Val Asp 50 55 60Ser
Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr65 70 75
80Leu Phe Leu Gln Met Asn Asn Leu Arg Asp Glu Asp Thr Ala Ile Tyr
85 90 95Tyr Cys Ala Lys Asn Gly Gly Asp Tyr Met Gly Ala Tyr Ile Asp
Asn 100 105 110Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
Ala Gln Ser Val Leu 130 135 140Thr Gln Pro Pro Ser Val Ser Ala Ala
Pro Gly Gln Lys Val Thr Ile145 150 155 160Ser Cys Ser Gly Ser Ser
Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 165 170 175Tyr Gln Gln Leu
Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 180 185 190Asn Lys
Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 195 200
205Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu
210 215 220Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Ser Ala
Gly Val225 230 235 240Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly
Ala Ala Ala His His 245 250 255His His His His Gly Glu Gln Lys Leu
Ile Ser Glu Glu Asp Leu 260 265 27089270PRTHomo
sapiensMOD_RES(267)..(267)Any amino acid 89Met Ala Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro1 5 10 15Gly Ser Ser Val Lys
Val Ser Cys Arg Ala Ser Gly Gly Thr Phe Arg 20 25 30Ser Tyr Ser Phe
Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu 35 40 45Trp Met Gly
Arg Ile Ile Pro Val Val Gly Val Leu Asp Tyr Ala Pro 50 55 60Lys Phe
Gln Ala Arg Val Thr Phe Thr Val Asp Thr Ser Thr Ser Val65 70 75
80Gly Tyr Met Asp Leu Asn Gly Leu Thr Pro Glu Asp Thr Ala Val Tyr
85 90 95Tyr Cys Ala Gly Gly Asp His Val Val Lys Ala Ala Leu Ala Tyr
Trp 100 105 110Gly Gly Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Gln Ser Ala Leu Thr 130 135 140Gln Pro Ala Ser Glu Ser Gly Ser Pro
Gly Gln Ser Ile Thr Ile Ser145 150 155 160Cys Thr Gly Thr Ser Thr
Asp Val Gly Ala Arg Asn Ser Val Ser Trp 165 170 175Tyr Gln Gln His
Pro Gly Lys Ala Pro Lys Leu Ile Leu Tyr Asp Val 180 185 190Ser His
Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser 195 200
205Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu
210 215 220Gly Asp Phe Tyr Cys Ser Ser Tyr Thr Thr Ser Asn Asn Leu
Val Phe225 230 235 240Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
Ala Ala His His His 245 250 255His His His Gly Glu Gln Lys Leu Ile
Ser Xaa Glu Asp Leu 260 265 27090270PRTHomo
sapiensMOD_RES(267)..(267)Any amino acid 90Met Ala Gln Val Gln Leu
Gln Gln Ser Gly Pro Gly Leu Val Lys Pro1 5 10 15Ser Glu Thr Leu Ser
Leu Thr Cys Thr Leu Ser Gly Gly Ser Met Glu 20 25 30Ser His Tyr Trp
Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45Trp Met Gly
Arg Val Ser Tyr Ile Gly Ile Ser Asn Tyr Asn Pro Tyr 50 55 60Leu Lys
Asn Arg Val Thr Ile Ser Gln Asp Lys Ser Lys Asn Gln Leu65 70 75
80Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95Cys Ala Arg His Arg Leu Arg Ser Asp Gln Ala Phe Asp Leu Trp
Gly 100 105 110Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
Ser Gly Gly 115 120 125Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala Gln
Ser Val Leu Thr Gln 130 135 140Pro Pro Ser Val Ser Gly Ala Pro Gly
Gln Arg Val Thr Ile Ser Cys145 150 155 160Thr Gly Ser Ser Ser Asn
Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 165 170 175Gln Gln Leu Pro
Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser 180 185 190Asn Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 195 200
205Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala
210 215 220Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser
Val Phe225 230 235 240Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala
Ala Ala His His His 245 250 255His His His Gly Glu Gln Lys Leu Ile
Ser Xaa Glu Asp Leu 260 265 27091269PRTHomo sapiens 91Met Ala Glu
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro1 5 10 15Gly Arg
Ser Leu Arg Leu Ser Cys Thr Ile Ser Gly Val Thr Phe Asn 20 25 30Gln
Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln 35 40
45Trp Leu Ser Thr Ile Ala Gly Thr Gly Thr Lys Thr Phe Tyr Ala Asp
50 55 60Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Ser Ser Gly Asn
Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr
Ala Val Tyr 85 90 95Tyr Cys Ala Lys Ser Leu Ser Met Arg Tyr Phe Leu
Asp Leu Trp Gly 100 105 110Arg
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120
125Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala Leu Pro Glu Leu Thr Gln
130 135 140Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile
Ser Cys145 150 155 160Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr
Val Asn Trp Tyr Gln 165 170 175Gln Leu Pro Gly Thr Ala Pro Lys Leu
Leu Ile Tyr Ser Asn Asn Gln 180 185 190Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser Gly Ser Lys Ser Gly Thr 195 200 205Ser Ala Ser Leu Ala
Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 210 215 220Tyr Tyr Cys
Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val Phe Gly225 230 235
240Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala His His His His
245 250 255His His Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 260
26592269PRTHomo sapiensMOD_RES(249)..(249)Any amino acid 92Met Ala
Glu Val Gln Leu Val Glu Thr Gly Gly Asp Leu Val Arg Pro1 5 10 15Gly
Gly Ser Leu Arg Leu Ser Cys Thr Ile Ser Gly Val Thr Phe Asn 20 25
30Gln Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln
35 40 45Trp Leu Ser Thr Ile Ala Gly Thr Gly Thr Lys Thr Phe Tyr Ala
Asp 50 55 60Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Ser Ser Gly
Asn Thr65 70 75 80Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp
Thr Ala Val Tyr 85 90 95Tyr Cys Ala Lys Ser Leu Ser Met Arg Tyr Phe
Leu Asp Leu Trp Gly 100 105 110Gln Gly Thr Met Val Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly 115 120 125Gly Gly Ser Gly Gly Gly Gly
Ser Ser Ala Gln Ser Val Leu Thr Gln 130 135 140Pro Pro Ser Ala Ser
Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys145 150 155 160Ser Gly
Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 165 170
175Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln
180 185 190Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser
Gly Thr 195 200 205Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
Asp Glu Ala Asp 210 215 220Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
Asn Gly Trp Val Phe Gly225 230 235 240Gly Gly Thr Lys Leu Thr Val
Leu Xaa Ala Ala Ala His His His His 245 250 255His His Gly Glu Gln
Lys Leu Ile Ser Glu Glu Asp Leu 260 26593272PRTHomo
sapiensMOD_RES(252)..(252)Any amino acid 93Met Ala Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro1 5 10 15Ser Glu Thr Leu Ser
Leu Thr Cys Ser Val Ser Gly Asp Ala Ile Ser 20 25 30Asn Gly Tyr Phe
Trp Gly Trp Ile Arg Gln Pro Pro Gly Gly Gly Leu 35 40 45Glu Trp Ile
Gly Ser Ile Ser His Arg Gly Ser Thr Tyr Tyr Asn Pro 50 55 60Ser Leu
Lys Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln65 70 75
80Phe Ser Leu Ser Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Phe
85 90 95Tyr Cys Ala Arg Ser Asn Gly Asp Tyr Asp Thr Phe Thr Ala Tyr
Tyr 100 105 110Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 115 120 125Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
Ala Gln Ala Val Leu 130 135 140Thr Gln Pro Pro Ser Val Ser Gly Ala
Pro Gly Gln Arg Val Thr Ile145 150 155 160Ser Cys Thr Gly Ser Ser
Ser Asn Ile Gly Ala Gly Tyr Asp Val His 165 170 175Trp Tyr Gln Gln
Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 180 185 190Asn Ser
Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 195 200
205Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp
210 215 220Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser
Gly Ser225 230 235 240Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
Xaa Ala Ala Ala His 245 250 255His His His His His Gly Glu Gln Lys
Leu Ile Ser Xaa Glu Asp Leu 260 265 27094270PRTHomo
sapiensMOD_RES(250)..(250)Any amino acid 94Met Ala Gln Val Gln Leu
Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro1 5 10 15Ser Gln Thr Leu Ser
Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser 20 25 30Ser Gly Asp His
Tyr Trp Asn Trp Ile Arg Gln Pro Ala Gly Lys Gly 35 40 45Leu Glu Trp
Ile Gly Arg Leu Tyr Thr Asn Gly Ile Thr Asp Tyr Asn 50 55 60Pro Ser
Leu Arg Ser Arg Val Ile Ile Ser Ala Asp Thr Ser Lys Asn65 70 75
80Gln Phe Thr Leu Lys Leu Ser Ala Val Thr Ala Ala Asp Thr Ala Val
85 90 95Tyr Tyr Cys Ala Arg Asp Val Trp Glu Pro Gly Thr Phe Glu His
Trp 100 105 110Gly Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ala
Leu Ser Ser Glu Leu 130 135 140Thr Gln Asp Pro Ala Val Ser Val Ala
Leu Gly Gln Thr Val Arg Ile145 150 155 160Thr Cys Gln Gly Asp Ser
Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 165 170 175Gln Lys Pro Gly
Gln Ala Pro Ile Leu Val Ile Tyr Gly Lys Asn Asn 180 185 190Arg Pro
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 195 200
205Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp
210 215 220Tyr Tyr Cys Asn Ser Arg Asp Ser Asn Gly Asp Val Leu Ser
Val Phe225 230 235 240Gly Gly Gly Thr Lys Leu Thr Val Leu Xaa Ala
Ala Ala His His His 245 250 255His His His Gly Glu Gln Lys Leu Ile
Ser Glu Glu Asp Leu 260 265 2709534PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
95Ser Thr Tyr Gly Met His Trp Val Ala Val Ser Ser Tyr Asp Gly Arg1
5 10 15Asn Glu Tyr Ala Lys Glu Val Gly Met Arg Ser Tyr Asp Ser Tyr
Gly 20 25 30Met Asp9634PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 96Thr Ser Tyr Gly Met His
Trp Val Ala Val Ile Ser Tyr Asp Gly Arg1 5 10 15Lys Lys Tyr Ala Lys
Asp Val Ser Leu Arg Ala Tyr Asp His Tyr Gly 20 25 30Met
Asp9734PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 97Ser Ser Tyr Gly Met His Trp Val Ala His Ile
Ser Tyr Asp Gly Thr1 5 10 15Glu Thr His Ala Lys Asp Val Ser Leu Arg
Ala Tyr Asp His Tyr Gly 20 25 30Met Asp9821PRTArtificial
SequenceDescription of Artificial Sequence Synthetic peptide 98Ser
Ser Tyr Gly Met His Trp Val Ala Val Ile Ser Tyr Asp Gly Ser1 5 10
15Asn Lys Tyr Ala Lys 20998PRTArtificial SequenceDescription of
Artificial Sequence Synthetic peptide 99Tyr Tyr Tyr Tyr Tyr Gly Met
Asp1 510034PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 100Xaa Xaa Tyr Gly Met His Trp Val Ala Xaa
Xaa Ser Tyr Asp Gly Xaa1 5 10 15Xaa Xaa Xaa Ala Lys Xaa Val Xaa Xaa
Arg Xaa Tyr Xaa Xaa Tyr Gly 20 25 30Met Asp10125PRTArtificial
SequenceDescription of Artificial Sequence Synthetic peptide 101Asn
Ser Trp Leu Ala Trp Tyr Val Leu Phe Gly Ala Ala Ser Ser Leu1 5 10
15Gln Gln Gln Ser Asn Asn Phe Pro Tyr 20 2510224PRTArtificial
SequenceDescription of Artificial Sequence Synthetic peptide 102Ser
Ser Trp Leu Ala Trp Tyr Leu Leu Ile Tyr Ala Ala Ser Ser Leu1 5 10
15Gln Gln Gln Ala Asn Ser Phe Pro 2010325PRTArtificial
SequenceDescription of Artificial Sequence Synthetic peptide 103Xaa
Ser Trp Leu Ala Trp Tyr Xaa Leu Xaa Xaa Ala Ala Ser Ser Leu1 5 10
15Gln Gln Gln Xaa Asn Xaa Phe Pro Tyr 20 2510427PRTArtificial
SequenceDescription of Artificial Sequence Synthetic peptide 104Asn
Tyr Tyr Ala Asn Trp Tyr Leu Val Ile Tyr Gly Gly Asn Ser Arg1 5 10
15Pro Asp Ser Arg Asp Ser Ser Asp Asn His Arg 20
2510526PRTArtificial SequenceDescription of Artificial Sequence
Synthetic peptide 105Ser Tyr Tyr Ala Ser Trp Tyr Leu Val Ile Tyr
Gly Lys Asn Asn Arg1 5 10 15Pro Asn Ser Arg Asp Ser Ser Gly Asn His
20 2510627PRTArtificial SequenceDescription of Artificial Sequence
Synthetic peptide 106Xaa Tyr Tyr Ala Xaa Trp Tyr Leu Val Ile Tyr
Gly Xaa Asn Xaa Arg1 5 10 15Pro Xaa Ser Arg Asp Ser Ser Xaa Asn His
Xaa 20 25
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