U.S. patent application number 13/436110 was filed with the patent office on 2012-10-04 for t7 rna polymerase variants with cysteine-serine substitutions. This patent application is currently assigned to ROCHE DIAGNOSTICS OPERATIONS, INC.. Invention is credited to Michael Greif, Christian Rudolph, Manfred Schmidt, Harald Sobek, Johann-Peter Thalhofer.
Application Number | 20120252071 13/436110 |
Document ID | / |
Family ID | 45874740 |
Filed Date | 2012-10-04 |
United States Patent Application | 20120252071 |
Kind Code | A1 |
Greif; Michael ; et al. | October 4, 2012 |
The present disclosure provide novel variants of T7 RNA polymerase. Embodiments of T7 variants, according to the instant invention, include a Cysteine-Serine substitution on position 723 of the amino acid sequence of the T7 polypeptide. Embodiments of T7 variants according to the instant invention have a DNA-dependent RNA polymerase enzymatic activity and a reduced tendency to form intramolecular homodimers by way of oxidizing thiol groups. The amino acid substitutions within the T7 variants disclosed herein impact minimally, if at all, the RNA polymerase activity of the T7 polypeptide. Further, the mutations of the disclosed embodiments may optionally be combined with mutations which provide enhanced thermostability compared to the wild-type reference.
Inventors: | Greif; Michael; (Penzberg, DE) ; Rudolph; Christian; (Penzberg, DE) ; Schmidt; Manfred; (Penzberg, DE) ; Sobek; Harald; (Penzberg, DE) ; Thalhofer; Johann-Peter; (Weilheim, DE) |
Assignee: | ROCHE DIAGNOSTICS OPERATIONS,
INC. Indianapolis IN |
Family ID: | 45874740 |
Appl. No.: | 13/436110 |
Filed: | March 30, 2012 |
Current U.S. Class: | 435/91.3 ; 435/194 |
Current CPC Class: | C12Y 207/07006 20130101; C12N 9/1247 20130101 |
Class at Publication: | 435/91.3 ; 435/194 |
International Class: | C12P 19/34 20060101 C12P019/34; C12N 9/12 20060101 C12N009/12 |
Date | Code | Application Number |
---|---|---|
Apr 1, 2011 | EP | 11160799.0 |
Sequence CWU 1
1
7612655DNAEscherichia colimisc_feature(1)..(2655)DNA sequence
encoding wild-type T7 DNA-dependent RNA polymerase, including start
codon encoding N-terminal methionine; corresponding to #1 in Table
3 1atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc
tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt
ggcccttgag 120catgagtctt acgagatggg tgaagcacgc ttccgcaaga
tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc
aagcctctca tcactaccct actccctaag 240atgattgcac gcatcaacga
ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc
agttcctgca agaaatcaag ccggaagccg tagcgtacat caccattaag
360accactctgg cttgcctaac cagtgctgac aatacaaccg ttcaggctgt
agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta
tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc
aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga
ggctgacatg ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt
ggcataagga agactctatt catgtaggag tacgctgcat cgagatgctc
660attgagtcaa ccggaatggt tagcttacac cgccaaaatg ctggcgtagt
aggtcaagac 720tctgagacta tcgaactcgc acctgaatac gctgaggcta
tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat gttccaacct
tgcgtagttc ctcctaagcc gtggactggc 840attactggtg gtggctattg
ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag
cactgatgcg ctacgaagac gtttacatgc ctgaggtgta caaagcgatt
960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag tcctagcggt
cgccaacgta 1020atcaccaagt ggaagcattg tccggtcgag gacatccctg
cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat
cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa
ggacaaggct cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc
aagccaataa gtttgctaac cataaggcca tctggttccc ttacaacatg
1260gactggcgcg gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa
cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta
aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc
gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga
gaacatcatg gcttgcgcta agtctccact ggagaacact 1500tggtgggctg
agcaagattc tccgttctgc ttccttgcgt tctgctttga gtacgctggg
1560gtacagcacc acggcctgag ctataactgc tcccttccgc tggcgtttga
cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg
taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc
tacgggattg ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat
caatgggacc gataacgaag tagttaccgt gaccgatgag 1800aacactggtg
aaatctctga gaaagtcaag ctgggcacta aggcactggc tggtcaatgg
1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag tcatgacgct
ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata
ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt cactcagccg
aatcaggctg ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt
gacggtggta gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta
agctgctggc tgctgaggtc aaagataaga agactggaga gattcttcgc
2160aagcgttgcg ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca
ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc
agttccgctt acagcctacc 2280attaacacca acaaagatag cgagattgat
gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac acagccaaga
cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa
tcgaatcttt tgcactgatt cacgactcct tcggtaccat tccggctgac
2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg acacatatga
gtcttgtgat 2520gtactggctg atttctacga ccagttcgct gaccagttgc
acgagtctca attggacaaa 2580atgccagcac ttccggctaa aggtaacttg
aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
26552883PRTEscherichia coliMISC_FEATURE(1)..(883)wild-type T7
DNA-dependent RNA polymerase, amino acid sequence including
N-terminal methionine; corresponding to #1 in Table 3 2Met Asn Thr
Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala
Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala
Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40
45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val
50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro
Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys
Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu
Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr
Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala
Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg
Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys
Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val
Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185
190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp
195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu
Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val
Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu
Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly
Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro
Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg
Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu
Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310
315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu
Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val
Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys
Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp
Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg
Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln
Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr
Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425
430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys
435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile
His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro
Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile
Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala
Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu
Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser
Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His
Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550
555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala
Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly
Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly
Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala
Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys
Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe
Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala
Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665
670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr
675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala
Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly
Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr
Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile
Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu
Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala
His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser
Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790
795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly
Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg
Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala
Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln
Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn
Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala32655DNAArtificial SequenceSynthetic coding polynucleotide
3atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
ctagcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 26554883PRTArtificial
SequenceSynthetic variant polypeptide 4Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Ser Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625
630 635 640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr
Ile Gln 645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr
Gln Pro Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp
Glu Ser Val Ser Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met
Asn Trp Leu Lys Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val
Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys
Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln
Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745
750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu
755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe
Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val
Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu
Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn
Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu
Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp
Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro
Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870
875 880Ala Phe Ala52655DNAArtificial SequenceSynthetic coding
polynucleotide 5atgaacacga ttaacatcgc taagaacgac ttctctgaca
tcgaactggc tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc
gcgaacagtt ggcccttgag 120catgagtctt acgagatggg tgaagcacgc
ttccgcaaga tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa
cgctgccgcc aagcctctca tcactaccct actccctaag 240atgattgcac
gcatcaacga ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg
300acagccttcc agttcctgca agaaatcaag ccggaagccg tagcgtacat
caccattaag 360accactctgg cttgcctaac cagtgctgac aatacaaccg
ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc
ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga
ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc
aagttgtcga ggctgacatg ctctctaagg gtctactcgg tggcgaggcg
600tggtcttcgt ggcataagga agactctatt catgtaggag tacgctgcat
cgagatgctc 660attgagtcaa ccggaatggt tagcttacac cgccaaaatg
ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc acctgaatac
gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat
gttccaacct tgcgtagttc ctcctaagcc gtggactggc 840attactggtg
gtggctattg ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac
900agtaagaaag cactgatgcg ctacgaagac gtttacatgc ctgaggtgta
caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag
tcctagcggt cgccaacgta 1020atcaccaagt ggaagcatag cccggtcgag
gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat
cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg
tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag ccttgagttc
1200atgcttgagc aagccaataa gtttgctaac cataaggcca tctggttccc
ttacaacatg 1260gactggcgcg gtcgtgttta cgctgtgtca atgttcaacc
cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa
ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg
tgcgggtgtc gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg
aaaaccacga gaacatcatg gcttgcgcta agtctccact ggagaacact
1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt tctgctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgctgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
26556883PRTArtificial SequenceSynthetic variant polypeptide 6Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Ser Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala72655DNAArtificial SequenceSynthetic coding polynucleotide
7atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gctagcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 26558883PRTArtificial
SequenceSynthetic variant polypeptide 8Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420
425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala
Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys
Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe
Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn
Ile Met Ala Ser Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp
Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe
Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys
Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala92655DNAArtificial SequenceSynthetic coding polynucleotide
9atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tcagctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265510883PRTArtificial
SequenceSynthetic variant polypeptide 10Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Ser Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala112655DNAArtificial SequenceSynthetic coding polynucleotide
11atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265512883PRTArtificial
SequenceSynthetic variant polypeptide 12Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210
215 220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala132655DNAArtificial SequenceSynthetic coding polynucleotide
13atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtctagcgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265514883PRTArtificial
SequenceSynthetic variant polypeptide 14Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Ser Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala152655DNAArtificial SequenceSynthetic coding polynucleotide
15atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
ctagcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcatag cccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gctagcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tcagctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtctagcgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265516883PRTArtificial
SequenceSynthetic variant polypeptide 16Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1
5 10 15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg
Leu 20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met
Gly Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala
Gly Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr
Leu Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu
Glu Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe
Leu Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile
Lys Thr Thr Leu Ala Ser Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr
Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp
Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155
160His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His
165 170 175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met
Leu Ser 180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp
His Lys Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu
Met Leu Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln
Asn Ala Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu
Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly
Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val
Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280
285Asn Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala
290 295 300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys
Ala Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn
Lys Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys
His Ser Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu
Leu Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala
Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys
Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395
400Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe
405 410 415Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser
Met Phe 420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu
Thr Leu Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr
Trp Leu Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys
Val Pro Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn
His Glu Asn Ile Met Ala Ser Ala Lys Ser Pro 485 490 495Leu Glu Asn
Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala
Phe Ser Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520
525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln
530 535 540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala
Val Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr
Gly Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp
Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp
Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr
Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg
Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635
640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln
645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro
Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser
Val Ser Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp
Leu Lys Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp
Lys Lys Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val
His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr
Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly
Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760
765Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His
770 775 780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala
His Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His
Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe
Lys Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Ser
Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu
His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys
Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875
880Ala Phe Ala172655DNAArtificial SequenceSynthetic coding
polynucleotide 17atgaacacga ttaacatcgc taagaacgac ttctctgaca
tcgaactggc tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc
gcgaacagtt ggcccttgag 120catgagtctt acgagatggg tgaagcacgc
ttccgcaaga tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa
cgctgccgcc aagcctctca tcactaccct actccctaag 240atgattgcac
gcatcaacga ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg
300acagccttcc agttcctgca agaaatcaag ccggaagccg tagcgtacat
caccattaag 360accactctgg cttgcctaac cagtgctgac aatacaaccg
ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc
ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga
ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc
aagttgtcga ggctgacatg ctctctaagg gtctactcgg tggcgaggcg
600tggtcttcgt ggcataagga agactctatt catgtaggag tacgctgcat
cgagatgctc 660attgagtcaa ccggaatggt tagcttacac cgccaaaatg
ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc acctgaatac
gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat
gttccaacct tgcgtagttc ctcctaagcc gtggactggc 840attactggtg
gtggctattg ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac
900agtaagaaag cactgatgcg ctacgaagac gtttacatgc ctgaggtgta
caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag
tcctagcggt cgccaacgta 1020atcaccaagt ggaagcattg tccggtcgag
gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat
cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg
tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag ccttgagttc
1200atgcttgagc aagccaataa gtttgctaac cataaggcca tctggttccc
ttacaacatg 1260gactggcgcg gtcgtctgta cgctgtgtca atgttcaacc
cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa
ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg
tgcgggtgtc gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg
aaaaccacga gaacatcatg gcttgcgcta agtctccact ggagaacact
1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt tctgctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgctgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265518883PRTArtificial SequenceSynthetic variant polypeptide 18Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala192655DNAArtificial SequenceSynthetic coding polynucleotide
19atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgctgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgtagcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265520883PRTArtificial SequenceSynthetic variant polypeptide 20Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala212655DNAArtificial SequenceSynthetic coding polynucleotide
21atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtatcta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265522883PRTArtificial
SequenceSynthetic variant polypeptide 22Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Ile Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala232655DNAArtificial SequenceSynthetic coding polynucleotide
23atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg
caagcgcccg 300acagccttcc agttcctgca agaaatcaag ccggaagccg
tagcgtacat caccattaag 360accactctgg cttgcctaac cagtgctgac
aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga
cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga
aaaacgttga ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa
540gcatttatgc aagttgtcga ggctgacatg ctctctaagg gtctactcgg
tggcgaggcg 600tggtcttcgt ggcataagga agactctatt catgtaggag
tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt tagcttacac
cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc
acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca
tctctccgat gttccaacct tgcgtagttc ctcctaagcc gtggactggc
840attactggtg gtggctattg ggctaacggt cgtcgtcctc tggcgctggt
gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac gtttacatgc
ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc
aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt ggaagcattg
tccggtcgag gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac
cggaagacat cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct
1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag
ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac cataaggcca
tctggttccc ttacaacatg 1260gactggcgcg gtcgtatcta cgctgtgtca
atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc
gaaaggtaaa ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg
gtgcaaactg tgcgggtgtc gataaggttc cgttccctga gcgcatcaag
1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta agtctccact
ggagaacact 1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt
tctgctttga gtacgctggg 1560gtacagcacc acggcctgag ctataactgc
tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc
cgcgatgctc cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta
gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa agtcaacgag
1740attctacaag cagacgcaat caatgggacc gataacgaag tagttaccgt
gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag ctgggcacta
aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact
aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg
tcaacaagtg ctggaagata ccattcagcc agctattgat 1980tccggcaagg
gtctgatgtt cactcagccg aatcaggctg ctggatacat ggctaagctg
2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa
ctggcttaag 2100tctgctgcta agctgctggc tgctgaggtc aaagataaga
agactggaga gattcttcgc 2160aagcgtagcg ctgtgcattg ggtaactcct
gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt
gaacctgatg ttcctcggtc agttccgctt acagcctacc 2280attaacacca
acaaagatag cgagattgat gcacacaaac aggagtctgg tatcgctcct
2340aactttgtac acagccaaga cggtagccac cttcgtaaga ctgtagtgtg
ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct
tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa
actatggttg acacatatga gtcttgtgat 2520gtactggctg atttctacga
ccagttcgct gaccagttgc acgagtctca attggacaaa 2580atgccagcac
ttccggctaa aggtaacttg aacctccgtg acatcttaga gtcggacttc
2640gcgttcgcgt aataa 265524883PRTArtificial SequenceSynthetic
variant polypeptide 24Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe
Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp
His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His
Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu
Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys
Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile
Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro
Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 100 105 110Ala Val
Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 115 120
125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala
130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu
Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn
Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala Phe Met Gln Val
Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu Leu Gly Gly Glu
Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser Ile His Val Gly
Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215 220Gly Met Val
Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp225 230 235
240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr
245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro
Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly
Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu Ala Leu Val Arg
Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr Glu Asp Val Tyr
Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn Ile Ala Gln Asn
Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330 335Val Ala Asn
Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 340 345 350Pro
Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 355 360
365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val
370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu
Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His
Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp Trp Arg Gly Arg
Ile Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln Gly Asn Asp Met
Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly Lys Pro Ile Gly
Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455 460Ala Asn Cys
Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys465 470 475
480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro
485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys
Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His
Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly
Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala Met Leu Arg Asp
Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu Leu Pro Ser Glu
Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570 575Lys Val Asn
Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu
Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600
605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly
610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala
Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu
Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu
Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys
Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val Val Ala Ala Val
Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695 700Leu Leu Ala
Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg705 710 715
720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp
725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met
Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn
Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile
Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg
Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu
Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala
Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val
Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840
845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu
850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser
Asp Phe865 870 875 880Ala Phe Ala252655DNAArtificial
SequenceSynthetic coding polynucleotide 25atgaacacga ttaacatcgc
taagaacgac ttctctgaca tcgaactggc tgctatcccg 60ttcaacactc tggctgacca
ttacggtgag cgtttagctc gcgaacagtt ggcccttgag 120catgagtctt
acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg tcaacttaaa
180gctggtgagg ttgcggataa cgctgccgcc aagcctctca tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg cttgcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcattg tccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtttcta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaagtg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgttgcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtcttgtgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265526883PRTArtificial
SequenceSynthetic variant polypeptide 26Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Phe Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp
725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met
Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn
Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile
Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg
Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu
Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala
Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val
Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840
845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu
850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser
Asp Phe865 870 875 880Ala Phe Ala272655DNAArtificial
SequenceSynthetic coding polynucleotide 27atgaacacga ttaacatcgc
taagaacgac ttctctgaca tcgaactggc tgctatcccg 60ttcaacactc tggctgacca
ttacggtgag cgtttagctc gcgaacagtt ggcccttgag 120catgagtctt
acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg tcaacttaaa
180gctggtgagg ttgcggataa cgctgccgcc aagcctctca tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg cttgcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcattg tccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtttcta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaagtg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgtagcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtcttgtgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265528883PRTArtificial
SequenceSynthetic variant polypeptide 28Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Phe Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala292655DNAArtificial SequenceSynthetic coding polynucleotide
29atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgtatgg tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265530883PRTArtificial
SequenceSynthetic variant polypeptide 30Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515
520 525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile
Gln 530 535 540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg
Ala Val Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile
Tyr Gly Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala
Asp Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr
Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly
Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr
Arg Ser Val Thr Lys Arg Met Val Met Thr Leu Ala Tyr Gly625 630 635
640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln
645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro
Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser
Val Ser Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp
Leu Lys Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp
Lys Lys Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val
His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr
Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly
Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760
765Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His
770 775 780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala
His Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His
Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe
Lys Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys
Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu
His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys
Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875
880Ala Phe Ala312655DNAArtificial SequenceSynthetic coding
polynucleotide 31atgaacacga ttaacatcgc taagaacgac ttctctgaca
tcgaactggc tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc
gcgaacagtt ggcccttgag 120catgagtctt acgagatggg tgaagcacgc
ttccgcaaga tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa
cgctgccgcc aagcctctca tcactaccct actccctaag 240atgattgcac
gcatcaacga ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg
300acagccttcc agttcctgca agaaatcaag ccggaagccg tagcgtacat
caccattaag 360accactctgg cttgcctaac cagtgctgac aatacaaccg
ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc
ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga
ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc
aagttgtcga ggctgacatg ctctctaagg gtctactcgg tggcgaggcg
600tggtcttcgt ggcataagga agactctatt catgtaggag tacgctgcat
cgagatgctc 660attgagtcaa ccggaatggt tagcttacac cgccaaaatg
ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc acctgaatac
gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat
gttccaacct tgcgtagttc ctcctaagcc gtggactggc 840attactggtg
gtggctattg ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac
900agtaagaaag cactgatgcg ctacgaagac gtttacatgc ctgaggtgta
caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag
tcctagcggt cgccaacgta 1020atcaccaagt ggaagcattg tccggtcgag
gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat
cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg
tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag ccttgagttc
1200atgcttgagc aagccaataa gtttgctaac cataaggcca tctggttccc
ttacaacatg 1260gactggcgcg gtcgtgttta cgctgtgtca atgttcaacc
cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa
ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg
tgcgggtgtc gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg
aaaaccacga gaacatcatg gcttgcgcta agtctccact ggagaacact
1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt tctgctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgtatgg
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgctgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgtagcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265532883PRTArtificial SequenceSynthetic variant polypeptide 32Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Met Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Ala Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala332655DNAArtificial SequenceSynthetic coding polynucleotide
33atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaactg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265534883PRTArtificial
SequenceSynthetic variant polypeptide 34Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310
315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu
Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val
Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys
Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp
Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg
Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln
Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr
Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425
430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys
435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile
His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro
Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile
Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala
Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu
Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser
Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His
Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550
555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala
Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly
Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly
Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala
Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys
Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe
Gly Phe Arg Gln Gln Leu Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala
Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665
670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr
675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala
Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly
Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr
Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile
Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu
Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala
His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser
Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790
795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly
Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg
Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala
Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln
Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn
Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala352655DNAArtificial SequenceSynthetic coding polynucleotide
35atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaactg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265536883PRTArtificial
SequenceSynthetic variant polypeptide 36Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Leu Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala372655DNAArtificial SequenceSynthetic coding polynucleotide
37atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagatc tgattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265538883PRTArtificial
SequenceSynthetic variant polypeptide 38Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100
105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr
Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile
Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg
Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu Glu
Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala Phe
Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu Leu
Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser Ile
His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Leu Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala392655DNAArtificial SequenceSynthetic coding polynucleotide
39atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagatc tgattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265540883PRTArtificial
SequenceSynthetic variant polypeptide 40Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Leu Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala412655DNAArtificial SequenceSynthetic coding polynucleotide
41atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265542883PRTArtificial SequenceSynthetic variant polypeptide 42Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Val Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala432655DNAArtificial SequenceSynthetic coding polynucleotide
43atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265544883PRTArtificial
SequenceSynthetic variant polypeptide 44Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala452655DNAArtificial SequenceSynthetic coding polynucleotide
45atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt
gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac gtttacatgc
ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc
aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt ggaagcattg
tccggtcgag gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac
cggaagacat cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct
1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag
ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac cataaggcca
tctggttccc ttacaacatg 1260gactggcgcg gtcgtgttta cgctgtgtca
atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc
gaaaggtaaa ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg
gtgcaaactg tgcgggtgtc gataaggttc cgttccctga gcgcatcaag
1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta agtctccact
ggagaacact 1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt
tctgctttga gtacgctggg 1560gtacagcacc acggcctgag ctataactgc
tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc
cgcgatgctc cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta
gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa agtcaacgag
1740attctacaag cagacgcaat caatgggacc gataacgaag tagttaccgt
gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag ctgggcacta
aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact
aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg
tcaacaagtg ctggaagata ccattcagcc agctattgat 1980tccggcaagg
gtctgatgtt cactcagccg aatcaggctg ctggatacat ggctaagctg
2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa
ctggcttaag 2100tctgctgcta agctgctggc tgctgaggtc aaagataaga
agactggaga gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct
gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt
gaacctgatg ttcctcggtc agttccgctt acagcctacc 2280attaacacca
acaaagatag cgagattgat gcacacaaac aggagtctgg tatcgctcct
2340aactttgtac acagccaaga cggtagccac cttcgtaaga ctatcgtgtg
ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct
tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa
actatggttg acacatatga gtcttgtgat 2520gtactggctg atttctacga
ccagttcgct gaccagttgc acgagtctca attggacaaa 2580atgccagcac
ttccggctaa aggtaacttg aacctccgtg acatcttaga gtcggacttc
2640gcgttcgcgt aataa 265546883PRTArtificial SequenceSynthetic
variant polypeptide 46Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe
Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp
His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His
Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu
Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys
Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile
Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro
Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 100 105 110Ala Val
Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 115 120
125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala
130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu
Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn
Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala Phe Met Gln Val
Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu Leu Gly Gly Glu
Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser Ile His Val Gly
Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215 220Gly Met Val
Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp225 230 235
240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr
245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro
Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly
Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu Ala Leu Val Arg
Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr Glu Asp Val Tyr
Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn Ile Ala Gln Asn
Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330 335Val Ala Asn
Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 340 345 350Pro
Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 355 360
365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val
370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu
Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His
Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp Trp Arg Gly Arg
Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln Gly Asn Asp Met
Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly Lys Pro Ile Gly
Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455 460Ala Asn Cys
Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys465 470 475
480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro
485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys
Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His
Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly
Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala Met Leu Arg Asp
Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu Leu Pro Ser Glu
Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570 575Lys Val Asn
Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu
Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600
605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly
610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala
Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu
Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu
Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys
Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val Val Ala Ala Val
Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695 700Leu Leu Ala
Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg705 710 715
720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp
725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met
Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn
Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile
Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg
Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu
Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala
Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val
Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840
845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu
850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser
Asp Phe865 870 875 880Ala Phe Ala472655DNAArtificial
SequenceSynthetic coding polynucleotide 47atgaacacga ttaacatcgc
taagaacgac ttctctgaca tcgaactggc tgctatcccg 60ttcaacactc tggctgacca
ttacggtgag cgtttagctc gcgaacagtt ggcccttgag 120catgagtctt
acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg tcaacttaaa
180gctggtgagg ttgcggataa cgctgccgcc aagcctctca tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg cttgcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcattg tccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtgttta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaagtg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgtagcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtcttgtgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265548883PRTArtificial
SequenceSynthetic variant polypeptide 48Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820
825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp
Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met
Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile
Leu Glu Ser Asp Phe865 870 875 880Ala Phe Ala492655DNAArtificial
SequenceSynthetic coding polynucleotide 49atgaacacga ttaacatcgc
taagaacgac ttctctgaca tcgaactggc tgctatcccg 60ttcaacactc tggctgacca
ttacggtgag cgtttagctc gcgaacagtt ggcccttgag 120catgagtctt
acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg tcaacttaaa
180gctggtgagg ttgcggataa cgctgccgcc aagcctctca tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg cttgcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcattg tccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtgttta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaagtg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgttgcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtcttgtgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265550883PRTArtificial
SequenceSynthetic variant polypeptide 50Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala512655DNAArtificial SequenceSynthetic coding polynucleotide
51atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtgttta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265552883PRTArtificial
SequenceSynthetic variant polypeptide 52Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615
620Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr
Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu
Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met
Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys Leu
Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val Val Ala Ala Val Glu
Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695 700Leu Leu Ala Ala
Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg705 710 715 720Lys
Arg Ser Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 725 730
735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu
740 745 750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp
Ser Glu 755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro
Asn Phe Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg Lys Thr
Ile Val Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe
Ala Leu Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala
Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr
Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe
Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855
860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp
Phe865 870 875 880Ala Phe Ala532655DNAArtificial SequenceSynthetic
coding polynucleotide 53atgaacacga ttaacatcgc taagaacgac ttctctgaca
tcgaactggc tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc
gcgaacagtt ggcccttgag 120catgagtctt acgagatggg tgaagcacgc
ttccgcaaga tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa
cgctgccgcc aagcctctca tcactaccct actccctaag 240atgattgcac
gcatcaacga ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg
300acagccttcc agttcctgca agaaatcaag ccggaagccg tagcgtacat
caccattaag 360accactctgg cttgcctaac cagtgctgac aatacaaccg
ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc
ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga
ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc
aagttgtcga ggctgacatg ctctctaagg gtctactcgg tggcgaggcg
600tggtcttcgt ggcataagga agactctatt catgtaggag tacgctgcat
cgagatgctc 660attgagtcaa ccggaatggt tagcttacac cgccaaaatg
ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc acctgaatac
gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat
gttccaacct tgcgtagttc ctcctaagcc gtggactggc 840attactggtg
gtggctattg ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac
900agtaagaaag cactgatgcg ctacgaagac gtttacatgc ctgaggtgta
caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag
tcctagcggt cgccaacgta 1020atcaccaagt ggaagcattg tccggtcgag
gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat
cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg
tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag ccttgagttc
1200atgcttgagc aagccaataa gtttgctaac cataaggcca tctggttccc
ttacaacatg 1260gactggcgcg gtcgtctgta cgctgtgtca atgttcaacc
cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa
ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg
tgcgggtgtc gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg
aaaaccacga gaacatcatg gcttgcgcta agtctccact ggagaacact
1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt tctgctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgttgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctgtagtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtcttgtgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265554883PRTArtificial SequenceSynthetic variant polypeptide 54Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Val Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Cys Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala552655DNAArtificial SequenceSynthetic coding polynucleotide
55atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctgtagtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265556883PRTArtificial
SequenceSynthetic variant polypeptide 56Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Val Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala572655DNAArtificial SequenceSynthetic coding polynucleotide
57atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265558883PRTArtificial
SequenceSynthetic variant polypeptide 58Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala592655DNAArtificial SequenceSynthetic coding polynucleotide
59atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgctgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265560883PRTArtificial
SequenceSynthetic variant polypeptide 60Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200
205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala612655DNAArtificial SequenceSynthetic coding polynucleotide
61atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgttgcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265562883PRTArtificial
SequenceSynthetic variant polypeptide 62Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala632655DNAArtificial SequenceSynthetic coding polynucleotide
63atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact ggagaacact 1500tggtgggctg agcaagattc
tccgttctgc ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc
acggcctgag ctataactgc tcccttccgc tggcgtttga cgggtcttgc
1620tctggcatcc agcacttctc cgcgatgctc cgagatgagg taggtggtcg
cgcggttaac 1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg
ttgctaagaa agtcaacgag 1740attctacaag cagacgcaat caatgggacc
gataacgaag tagttaccgt gaccgatgag 1800aacactggtg aaatctctga
gaaagtcaag ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg
gtgttactcg cagtgtgact aagcgttcag tcatgacgct ggcttacggg
1920tccaaagagt tcggcttccg tcaacaagtg ctggaagata ccattcagcc
agctattgat 1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg
ctggatacat ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta
gctgcggttg aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc
tgctgaggtc aaagataaga agactggaga gattcttcgc 2160aagcgtagcg
ctgtgcattg ggtaactcct gatggtttcc ctgtgtggca ggaatacaag
2220aagcctattc agacgcgctt gaacctgatg ttcctcggtc agttccgctt
acagcctacc 2280attaacacca acaaagatag cgagattgat gcacacaaac
aggagtctgg tatcgctcct 2340aactttgtac acagccaaga cggtagccac
cttcgtaaga ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt
tgcactgatt cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc
tgttcaaagc agtgcgcgaa actatggttg acacatatga gtcttgtgat
2520gtactggctg atttctacga ccagttcgct gaccagttgc acgagtctca
attggacaaa 2580atgccagcac ttccggctaa aggtaacttg aacctccgtg
acatcttaga gtcggacttc 2640gcgttcgcgt aataa 265564883PRTArtificial
SequenceSynthetic variant polypeptide
64Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1
5 10 15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg
Leu 20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met
Gly Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala
Gly Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr
Leu Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu
Glu Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe
Leu Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile
Lys Thr Thr Leu Ala Cys Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr
Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp
Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155
160His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His
165 170 175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met
Leu Ser 180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp
His Lys Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu
Met Leu Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln
Asn Ala Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu
Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly
Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val
Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280
285Asn Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala
290 295 300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys
Ala Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn
Lys Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys
His Cys Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu
Leu Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala
Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys
Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395
400Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe
405 410 415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser
Met Phe 420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu
Thr Leu Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr
Trp Leu Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys
Val Pro Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn
His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro 485 490 495Leu Glu Asn
Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala
Phe Cys Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520
525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln
530 535 540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala
Val Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr
Gly Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp
Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp
Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr
Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg
Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635
640Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln
645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro
Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser
Val Ser Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp
Leu Lys Ser Val Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp
Lys Lys Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val
His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr
Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly
Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760
765Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His
770 775 780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Ile Val Trp Ala
His Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His
Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe
Lys Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Cys
Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu
His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys
Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875
880Ala Phe Ala652655DNAArtificial SequenceSynthetic coding
polynucleotide 65atgaacacga ttaacatcgc taagaacgac ttctctgaca
tcgaactggc tgctatcccg 60ttcaacactc tggctgacca ttacggtgag cgtttagctc
gcgaacagtt ggcccttgag 120catgagtctt acgagatggg tgaagcacgc
ttccgcaaga tgtttgagcg tcaacttaaa 180gctggtgagg ttgcggataa
cgctgccgcc aagcctctca tcactaccct actccctaag 240atgattgcac
gcatcaacga ctggtttgag gaagtgaaag ctaagcgcgg caagcgcccg
300acagccttcc agttcctgca agaaatcaag ccggaagccg tagcgtacat
caccattaag 360accactctgg ctagcctaac cagtgctgac aatacaaccg
ttcaggctgt agcaagcgca 420atcggtcggg ccattgagga cgaggctcgc
ttcggtcgta tccgtgacct tgaagctaag 480cacttcaaga aaaacgttga
ggaacaactc aacaagcgcg tagggcacgt ctacaagaaa 540gcatttatgc
aagttgtcga ggctgacatg ctctctaagg gtctactcgg tggcgaggcg
600tggtcttcgt ggcataagga agactctatt catgtaggag tacgctgcat
cgagatgctc 660attgagtcaa ccggaatggt tagcttacac cgccaaaatg
ctggcgtagt aggtcaagac 720tctgagacta tcgaactcgc acctgaatac
gctgaggcta tcgcaacccg tgcaggtgcg 780ctggctggca tctctccgat
gttccaacct tgcgtagttc ctcctaagcc gtggactggc 840attactggtg
gtggctattg ggctaacggt cgtcgtcctc tggcgctggt gcgtactcac
900agtaagaaag cactgatgcg ctacgaagac gtttacatgc ctgaggtgta
caaagcgatt 960aacattgcgc aaaacaccgc atggaaaatc aacaagaaag
tcctagcggt cgccaacgta 1020atcaccaagt ggaagcatag cccggtcgag
gacatccctg cgattgagcg tgaagaactc 1080ccgatgaaac cggaagacat
cgacatgaat cctgaggctc tcaccgcgtg gaaacgtgct 1140gccgctgctg
tgtaccgcaa ggacaaggct cgcaagtctc gccgtatcag ccttgagttc
1200atgcttgagc aagccaataa gtttgctaac cataaggcca tctggttccc
ttacaacatg 1260gactggcgcg gtcgtctgta cgctgtgtca atgttcaacc
cgcaaggtaa cgatatgacc 1320aaaggactgc ttacgctggc gaaaggtaaa
ccaatcggta aggaaggtta ctactggctg 1380aaaatccacg gtgcaaactg
tgcgggtgtc gataaggttc cgttccctga gcgcatcaag 1440ttcattgagg
aaaaccacga gaacatcatg gctagcgcta agtctccact ggagaacact
1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt tcagctttga
gtacgctggg 1560gtacagcacc acggcctgag ctataactgc tcccttccgc
tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc cgcgatgctc
cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta gtgaaaccgt
tcaggacatc tacgggattg ttgctaagaa agtcaacgag 1740attctacaag
cagacgcaat caatgggacc gataacgaag tagttaccgt gaccgatgag
1800aacactggtg aaatctctga gaaagtcaag ctgggcacta aggcactggc
tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact aagcgttcag
tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg tcaacaagtg
ctggaagata ccattcagcc agctattgat 1980tccggcaagg gtctgatgtt
cactcagccg aatcaggctg ctggatacat ggctaagctg 2040atttgggaat
ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa ctggcttaag
2100tctgttgcta agctgctggc tgctgaggtc aaagataaga agactggaga
gattcttcgc 2160aagcgtagcg ctgtgcattg ggtaactcct gatggtttcc
ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt gaacctgatg
ttcctcggtc agttccgctt acagcctacc 2280attaacacca acaaagatag
cgagattgat gcacacaaac aggagtctgg tatcgctcct 2340aactttgtac
acagccaaga cggtagccac cttcgtaaga ctatcgtgtg ggcacacgag
2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct tcggtaccat
tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa actatggttg
acacatatga gtctagcgat 2520gtactggctg atttctacga ccagttcgct
gaccagttgc acgagtctca attggacaaa 2580atgccagcac ttccggctaa
aggtaacttg aacctccgtg acatcttaga gtcggacttc 2640gcgttcgcgt aataa
265566883PRTArtificial SequenceSynthetic variant polypeptide 66Met
Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10
15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu
20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly
Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly
Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu
Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu
Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu
Gln Glu Ile Lys Pro Glu 100 105 110Ala Val Ala Tyr Ile Thr Ile Lys
Thr Thr Leu Ala Ser Leu Thr Ser 115 120 125Ala Asp Asn Thr Thr Val
Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu
Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys145 150 155 160His
Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 165 170
175Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser
180 185 190Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys
Glu Asp 195 200 205Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu
Ile Glu Ser Thr 210 215 220Gly Met Val Ser Leu His Arg Gln Asn Ala
Gly Val Val Gly Gln Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala
Pro Glu Tyr Ala Glu Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu
Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro
Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn
Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295
300Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala
Ile305 310 315 320Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys
Lys Val Leu Ala 325 330 335Val Ala Asn Val Ile Thr Lys Trp Lys His
Ser Pro Val Glu Asp Ile 340 345 350Pro Ala Ile Glu Arg Glu Glu Leu
Pro Met Lys Pro Glu Asp Ile Asp 355 360 365Met Asn Pro Glu Ala Leu
Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp
Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe385 390 395 400Met
Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 405 410
415Pro Tyr Asn Met Asp Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe
420 425 430Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu
Ala Lys 435 440 445Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu
Lys Ile His Gly 450 455 460Ala Asn Cys Ala Gly Val Asp Lys Val Pro
Phe Pro Glu Arg Ile Lys465 470 475 480Phe Ile Glu Glu Asn His Glu
Asn Ile Met Ala Ser Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp
Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Ser
Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 515 520 525Asn
Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535
540His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val
Asn545 550 555 560Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly
Ile Val Ala Lys 565 570 575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala
Ile Asn Gly Thr Asp Asn 580 585 590Glu Val Val Thr Val Thr Asp Glu
Asn Thr Gly Glu Ile Ser Glu Lys 595 600 605Val Lys Leu Gly Thr Lys
Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser
Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly625 630 635 640Ser
Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 645 650
655Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln
660 665 670Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser
Val Thr 675 680 685Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys
Ser Val Ala Lys 690 695 700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys
Thr Gly Glu Ile Leu Arg705 710 715 720Lys Arg Ser Ala Val His Trp
Val Thr Pro Asp Gly Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys
Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe
Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile
Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775
780Ser Gln Asp Gly Ser His Leu Arg Lys Thr Ile Val Trp Ala His
Glu785 790 795 800Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp
Ser Phe Gly Thr 805 810 815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys
Ala Val Arg Glu Thr Met 820 825 830Val Asp Thr Tyr Glu Ser Ser Asp
Val Leu Ala Asp Phe Tyr Asp Gln 835 840 845Phe Ala Asp Gln Leu His
Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 850 855 860Pro Ala Lys Gly
Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe865 870 875 880Ala
Phe Ala672655DNAArtificial SequenceSynthetic coding polynucleotide
67atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct actccctaag 240atgattgcac gcatcaacga ctggtttgag
gaagtgaaag ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca
agaaatcaag ccggaagccg tagcgtacat caccattaag 360accactctgg
cttgcctaac cagtgctgac aatacaaccg ttcaggctgt agcaagcgca
420atcggtcggg ccattgagga cgaggctcgc ttcggtcgta tccgtgacct
tgaagctaag 480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg
tagggcacgt ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg
ctctctaagg gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga
agactctatt catgtaggag tacgctgcat cgagatgctc 660attgagtcaa
ccggaatggt tagcttacac cgccaaaatg ctggcgtagt aggtcaagac
720tctgagacta tcgaactcgc acctgaatac gctgaggcta tcgcaacccg
tgcaggtgcg 780ctggctggca tctctccgat gttccaacct tgcgtagttc
ctcctaagcc gtggactggc 840attactggtg gtggctattg ggctaacggt
cgtcgtcctc tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg
ctacgaagac gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc
aaaacaccgc atggaaaatc aacaagaaag tcctagcggt cgccaacgta
1020atcaccaagt ggaagcattg tccggtcgag gacatccctg cgattgagcg
tgaagaactc 1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc
tcaccgcgtg gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct
cgcaagtctc gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa
gtttgctaac cataaggcca tctggttccc ttacaacatg 1260gactggcgcg
gtcgtctgta cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc
1320aaaggactgc ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta
ctactggctg 1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc
cgttccctga gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg
gcttgcgcta agtctccact
ggagaacact 1500tggtgggctg agcaagattc tccgttctgc ttccttgcgt
tctgctttga gtacgctggg 1560gtacagcacc acggcctgag ctataactgc
tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc agcacttctc
cgcgatgctc cgagatgagg taggtggtcg cgcggttaac 1680ttgcttccta
gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa agtcaacgag
1740attctacaag cagacgcaat caatgggacc gataacgaag tagttaccgt
gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag ctgggcacta
aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg cagtgtgact
aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt tcggcttccg
tcaacaactg ctggaagata ccattcagcc agctattgat 1980tccggcaagg
gtctgatgtt cactcagccg aatcaggctg ctggatacat ggctaagctg
2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg aagcaatgaa
ctggcttaag 2100tctgttgcta agctgctggc tgctgaggtc aaagataaga
agactggaga gattcttcgc 2160aagcgttgcg ctgtgcattg ggtaactcct
gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc agacgcgctt
gaacctgatg ttcctcggtc agttccgctt acagcctacc 2280attaacacca
acaaagatag cgagattgat gcacacaaac aggagtctgg tatcgctcct
2340aactttgtac acagccaaga cggtagccac cttcgtaaga ctatcgtgtg
ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt cacgactcct
tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc agtgcgcgaa
actatggttg acacatatga gtcttgtgat 2520gtactggctg atttctacga
ccagttcgct gaccagttgc acgagtctca attggacaaa 2580atgccagcac
ttccggctaa aggtaacttg aacctccgtg acatcttaga gtcggacttc
2640gcgttcgcgt aataa 265568883PRTArtificial SequenceSynthetic
variant polypeptide 68Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe
Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp
His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu Ala Leu Glu His
Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg Lys Met Phe Glu
Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn Ala Ala Ala Lys
Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met Ile Ala Arg Ile
Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90 95Gly Lys Arg Pro
Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 100 105 110Ala Val
Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 115 120
125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala
130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu
Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn
Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala Phe Met Gln Val
Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu Leu Gly Gly Glu
Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser Ile His Val Gly
Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215 220Gly Met Val
Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp225 230 235
240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr
245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro
Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly
Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu Ala Leu Val Arg
Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr Glu Asp Val Tyr
Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn Ile Ala Gln Asn
Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330 335Val Ala Asn
Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 340 345 350Pro
Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 355 360
365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val
370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu
Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His
Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp Trp Arg Gly Arg
Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln Gly Asn Asp Met
Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly Lys Pro Ile Gly
Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455 460Ala Asn Cys
Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys465 470 475
480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro
485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys
Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His
Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly
Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala Met Leu Arg Asp
Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu Leu Pro Ser Glu
Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570 575Lys Val Asn
Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 580 585 590Glu
Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 595 600
605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly
610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala
Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg Gln Gln Leu Leu
Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser Gly Lys Gly Leu
Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly Tyr Met Ala Lys
Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val Val Ala Ala Val
Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695 700Leu Leu Ala
Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg705 710 715
720Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp
725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met
Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn
Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln Glu Ser Gly Ile
Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly Ser His Leu Arg
Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys Tyr Gly Ile Glu
Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810 815Ile Pro Ala
Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 820 825 830Val
Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 835 840
845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu
850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser
Asp Phe865 870 875 880Ala Phe Ala692655DNAArtificial
SequenceSynthetic coding polynucleotide 69atgaacacga ttaacatcgc
taagaacgac ttctctgaca tcgaactggc tgctatcccg 60ttcaacactc tggctgacca
ttacggtgag cgtttagctc gcgaacagtt ggcccttgag 120catgagtctt
acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg tcaacttaaa
180gctggtgagg ttgcggataa cgctgccgcc aagcctctca tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg cttgcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcattg tccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtctgta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gcttgcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tctgctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaactg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgtagcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtcttgtgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265570883PRTArtificial
SequenceSynthetic variant polypeptide 70Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Cys Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Leu Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe
Ala712655DNAArtificial SequenceSynthetic coding polynucleotide
71atgaacacga ttaacatcgc taagaacgac ttctctgaca tcgaactggc tgctatcccg
60ttcaacactc tggctgacca ttacggtgag cgtttagctc gcgaacagtt ggcccttgag
120catgagtctt acgagatggg tgaagcacgc ttccgcaaga tgtttgagcg
tcaacttaaa 180gctggtgagg ttgcggataa cgctgccgcc aagcctctca
tcactaccct
actccctaag 240atgattgcac gcatcaacga ctggtttgag gaagtgaaag
ctaagcgcgg caagcgcccg 300acagccttcc agttcctgca agaaatcaag
ccggaagccg tagcgtacat caccattaag 360accactctgg ctagcctaac
cagtgctgac aatacaaccg ttcaggctgt agcaagcgca 420atcggtcggg
ccattgagga cgaggctcgc ttcggtcgta tccgtgacct tgaagctaag
480cacttcaaga aaaacgttga ggaacaactc aacaagcgcg tagggcacgt
ctacaagaaa 540gcatttatgc aagttgtcga ggctgacatg ctctctaagg
gtctactcgg tggcgaggcg 600tggtcttcgt ggcataagga agactctatt
catgtaggag tacgctgcat cgagatgctc 660attgagtcaa ccggaatggt
tagcttacac cgccaaaatg ctggcgtagt aggtcaagac 720tctgagacta
tcgaactcgc acctgaatac gctgaggcta tcgcaacccg tgcaggtgcg
780ctggctggca tctctccgat gttccaacct tgcgtagttc ctcctaagcc
gtggactggc 840attactggtg gtggctattg ggctaacggt cgtcgtcctc
tggcgctggt gcgtactcac 900agtaagaaag cactgatgcg ctacgaagac
gtttacatgc ctgaggtgta caaagcgatt 960aacattgcgc aaaacaccgc
atggaaaatc aacaagaaag tcctagcggt cgccaacgta 1020atcaccaagt
ggaagcatag cccggtcgag gacatccctg cgattgagcg tgaagaactc
1080ccgatgaaac cggaagacat cgacatgaat cctgaggctc tcaccgcgtg
gaaacgtgct 1140gccgctgctg tgtaccgcaa ggacaaggct cgcaagtctc
gccgtatcag ccttgagttc 1200atgcttgagc aagccaataa gtttgctaac
cataaggcca tctggttccc ttacaacatg 1260gactggcgcg gtcgtctgta
cgctgtgtca atgttcaacc cgcaaggtaa cgatatgacc 1320aaaggactgc
ttacgctggc gaaaggtaaa ccaatcggta aggaaggtta ctactggctg
1380aaaatccacg gtgcaaactg tgcgggtgtc gataaggttc cgttccctga
gcgcatcaag 1440ttcattgagg aaaaccacga gaacatcatg gctagcgcta
agtctccact ggagaacact 1500tggtgggctg agcaagattc tccgttctgc
ttccttgcgt tcagctttga gtacgctggg 1560gtacagcacc acggcctgag
ctataactgc tcccttccgc tggcgtttga cgggtcttgc 1620tctggcatcc
agcacttctc cgcgatgctc cgagatgagg taggtggtcg cgcggttaac
1680ttgcttccta gtgaaaccgt tcaggacatc tacgggattg ttgctaagaa
agtcaacgag 1740attctacaag cagacgcaat caatgggacc gataacgaag
tagttaccgt gaccgatgag 1800aacactggtg aaatctctga gaaagtcaag
ctgggcacta aggcactggc tggtcaatgg 1860ctggcttacg gtgttactcg
cagtgtgact aagcgttcag tcatgacgct ggcttacggg 1920tccaaagagt
tcggcttccg tcaacaactg ctggaagata ccattcagcc agctattgat
1980tccggcaagg gtctgatgtt cactcagccg aatcaggctg ctggatacat
ggctaagctg 2040atttgggaat ctgtgagcgt gacggtggta gctgcggttg
aagcaatgaa ctggcttaag 2100tctgttgcta agctgctggc tgctgaggtc
aaagataaga agactggaga gattcttcgc 2160aagcgtagcg ctgtgcattg
ggtaactcct gatggtttcc ctgtgtggca ggaatacaag 2220aagcctattc
agacgcgctt gaacctgatg ttcctcggtc agttccgctt acagcctacc
2280attaacacca acaaagatag cgagattgat gcacacaaac aggagtctgg
tatcgctcct 2340aactttgtac acagccaaga cggtagccac cttcgtaaga
ctatcgtgtg ggcacacgag 2400aagtacggaa tcgaatcttt tgcactgatt
cacgactcct tcggtaccat tccggctgac 2460gctgcgaacc tgttcaaagc
agtgcgcgaa actatggttg acacatatga gtctagcgat 2520gtactggctg
atttctacga ccagttcgct gaccagttgc acgagtctca attggacaaa
2580atgccagcac ttccggctaa aggtaacttg aacctccgtg acatcttaga
gtcggacttc 2640gcgttcgcgt aataa 265572883PRTArtificial
SequenceSynthetic variant polypeptide 72Met Asn Thr Ile Asn Ile Ala
Lys Asn Asp Phe Ser Asp Ile Glu Leu1 5 10 15Ala Ala Ile Pro Phe Asn
Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 20 25 30Ala Arg Glu Gln Leu
Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 35 40 45Ala Arg Phe Arg
Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 50 55 60Ala Asp Asn
Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys65 70 75 80Met
Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 85 90
95Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu
100 105 110Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Ser Leu
Thr Ser 115 120 125Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala
Ile Gly Arg Ala 130 135 140Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile
Arg Asp Leu Glu Ala Lys145 150 155 160His Phe Lys Lys Asn Val Glu
Glu Gln Leu Asn Lys Arg Val Gly His 165 170 175Val Tyr Lys Lys Ala
Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 180 185 190Lys Gly Leu
Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 195 200 205Ser
Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 210 215
220Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln
Asp225 230 235 240Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu
Ala Ile Ala Thr 245 250 255Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro
Met Phe Gln Pro Cys Val 260 265 270Val Pro Pro Lys Pro Trp Thr Gly
Ile Thr Gly Gly Gly Tyr Trp Ala 275 280 285Asn Gly Arg Arg Pro Leu
Ala Leu Val Arg Thr His Ser Lys Lys Ala 290 295 300Leu Met Arg Tyr
Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile305 310 315 320Asn
Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 325 330
335Val Ala Asn Val Ile Thr Lys Trp Lys His Ser Pro Val Glu Asp Ile
340 345 350Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp
Ile Asp 355 360 365Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala
Ala Ala Ala Val 370 375 380Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg
Arg Ile Ser Leu Glu Phe385 390 395 400Met Leu Glu Gln Ala Asn Lys
Phe Ala Asn His Lys Ala Ile Trp Phe 405 410 415Pro Tyr Asn Met Asp
Trp Arg Gly Arg Leu Tyr Ala Val Ser Met Phe 420 425 430Asn Pro Gln
Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 435 440 445Gly
Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 450 455
460Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile
Lys465 470 475 480Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Ser
Ala Lys Ser Pro 485 490 495Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp
Ser Pro Phe Cys Phe Leu 500 505 510Ala Phe Ser Phe Glu Tyr Ala Gly
Val Gln His His Gly Leu Ser Tyr 515 520 525Asn Cys Ser Leu Pro Leu
Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 530 535 540His Phe Ser Ala
Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn545 550 555 560Leu
Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 565 570
575Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn
580 585 590Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser
Glu Lys 595 600 605Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp
Leu Ala Tyr Gly 610 615 620Val Thr Arg Ser Val Thr Lys Arg Ser Val
Met Thr Leu Ala Tyr Gly625 630 635 640Ser Lys Glu Phe Gly Phe Arg
Gln Gln Leu Leu Glu Asp Thr Ile Gln 645 650 655Pro Ala Ile Asp Ser
Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 660 665 670Ala Ala Gly
Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 675 680 685Val
Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Val Ala Lys 690 695
700Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu
Arg705 710 715 720Lys Arg Ser Ala Val His Trp Val Thr Pro Asp Gly
Phe Pro Val Trp 725 730 735Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg
Leu Asn Leu Met Phe Leu 740 745 750Gly Gln Phe Arg Leu Gln Pro Thr
Ile Asn Thr Asn Lys Asp Ser Glu 755 760 765Ile Asp Ala His Lys Gln
Glu Ser Gly Ile Ala Pro Asn Phe Val His 770 775 780Ser Gln Asp Gly
Ser His Leu Arg Lys Thr Ile Val Trp Ala His Glu785 790 795 800Lys
Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 805 810
815Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met
820 825 830Val Asp Thr Tyr Glu Ser Ser Asp Val Leu Ala Asp Phe Tyr
Asp Gln 835 840 845Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys
Met Pro Ala Leu 850 855 860Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp
Ile Leu Glu Ser Asp Phe865 870 875 880Ala Phe Ala7333DNAArtificial
SequenceSynthetic oligonucleotide 73atgcatcacc atcatcacca
cggatccatg aac 337411PRTArtificial SequenceSynthetic peptide 74Met
His His His His His His Gly Ser Met Asn1 5 10757PRTArtificial
SequenceSynthetic His tag 75His His His His His His His1
5766PRTArtificial SequenceSynthetic 6xHis (His6) tag 76His His His
His His His1 5
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