U.S. patent application number 13/162165 was filed with the patent office on 2012-06-14 for yeast production culture for the production of butanol. This patent application is currently assigned to Butamax(TM) Advanced Biofuels LLC. Invention is credited to Michael G. Bramucci, VASANTHA NAGARAJAN.
Application Number | 20120149080 13/162165 |
Document ID | / |
Family ID | 44627329 |
Filed Date | 2012-06-14 |
United States Patent Application | 20120149080 |
Kind Code | A1 |
NAGARAJAN; VASANTHA ; et al. | June 14, 2012 |
High cell density cultures of yeast were found to have higher tolerance for butanol in the medium. The high cell density yeast cultures had greater survival and higher glucose utilization than cultures with low cell densities. Production of butanol using yeast in high cell density cultures is thus beneficial for improving butanol production.
Inventors: | NAGARAJAN; VASANTHA; (Wilmington, DE) ; Bramucci; Michael G.; (Boothwyn, PA) |
Assignee: | Butamax(TM) Advanced Biofuels
LLC Wilmington DE |
Family ID: | 44627329 |
Appl. No.: | 13/162165 |
Filed: | June 16, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
61355733 | Jun 17, 2010 | |||
Current U.S. Class: | 435/160 ; 435/254.2; 435/255.21; 435/255.4; 435/255.5; 435/255.7 |
Current CPC Class: | C12N 15/01 20130101; C12P 7/16 20130101; C12N 1/16 20130101; C12R 1/645 20130101; C12R 1/865 20130101; Y02E 50/10 20130101 |
Class at Publication: | 435/160 ; 435/255.7; 435/254.2; 435/255.21; 435/255.4; 435/255.5 |
International Class: | C12P 7/16 20060101 C12P007/16; C12N 1/19 20060101 C12N001/19; C12N 1/16 20060101 C12N001/16 |
Sequence CWU 1
1
7911680DNAK. pneumoniae 1atggacaaac agtatccggt acgccagtgg
gcgcacggcg ccgatctcgt cgtcagtcag 60ctggaagctc agggagtacg ccaggtgttc
ggcatccccg gcgccaaaat cgacaaggtc 120tttgattcac tgctggattc
ctccattcgc attattccgg tacgccacga agccaacgcc 180gcatttatgg
ccgccgccgt cggacgcatt accggcaaag cgggcgtggc gctggtcacc
240tccggtccgg gctgttccaa cctgatcacc ggcatggcca ccgcgaacag
cgaaggcgac 300ccggtggtgg ccctgggcgg cgcggtaaaa cgcgccgata
aagcgaagca ggtccaccag 360agtatggata cggtggcgat gttcagcccg
gtcaccaaat acgccatcga ggtgacggcg 420ccggatgcgc tggcggaagt
ggtctccaac gccttccgcg ccgccgagca gggccggccg 480ggcagcgcgt
tcgttagcct gccgcaggat gtggtcgatg gcccggtcag cggcaaagtg
540ctgccggcca gcggggcccc gcagatgggc gccgcgccgg atgatgccat
cgaccaggtg 600gcgaagctta tcgcccaggc gaagaacccg atcttcctgc
tcggcctgat ggccagccag 660ccggaaaaca gcaaggcgct gcgccgtttg
ctggagacca gccatattcc agtcaccagc 720acctatcagg ccgccggagc
ggtgaatcag gataacttct ctcgcttcgc cggccgggtt 780gggctgttta
acaaccaggc cggggaccgt ctgctgcagc tcgccgacct ggtgatctgc
840atcggctaca gcccggtgga atacgaaccg gcgatgtgga acagcggcaa
cgcgacgctg 900gtgcacatcg acgtgctgcc cgcctatgaa gagcgcaact
acaccccgga tgtcgagctg 960gtgggcgata tcgccggcac tctcaacaag
ctggcgcaaa atatcgatca tcggctggtg 1020ctctccccgc aggcggcgga
gatcctccgc gaccgccagc accagcgcga gctgctggac 1080cgccgcggcg
cgcagctcaa ccagtttgcc ctgcatcccc tgcgcatcgt tcgcgccatg
1140caggatatcg tcaacagcga cgtcacgttg accgtggaca tgggcagctt
ccatatctgg 1200attgcccgct acctgtacac gttccgcgcc cgtcaggtga
tgatctccaa cggccagcag 1260accatgggcg tcgccctgcc ctgggctatc
ggcgcctggc tggtcaatcc tgagcgcaaa 1320gtggtctccg tctccggcga
cggcggcttc ctgcagtcga gcatggagct ggagaccgcc 1380gtccgcctga
aagccaacgt gctgcatctt atctgggtcg ataacggcta caacatggtc
1440gctatccagg aagagaaaaa atatcagcgc ctgtccggcg tcgagtttgg
gccgatggat 1500tttaaagcct atgccgaatc cttcggcgcg aaagggtttg
ccgtggaaag cgccgaggcg 1560ctggagccga ccctgcgcgc ggcgatggac
gtcgacggcc cggcggtagt ggccatcccg 1620gtggattatc gcgataaccc
gctgctgatg ggccagctgc atctgagtca gattctgtaa 16802559PRTK.
pneumoniae 2Met Asp Lys Gln Tyr Pro Val Arg Gln Trp Ala His Gly Ala
Asp Leu1 5 10 15Val Val Ser Gln Leu Glu Ala Gln Gly Val Arg Gln Val
Phe Gly Ile 20 25 30Pro Gly Ala Lys Ile Asp Lys Val Phe Asp Ser Leu
Leu Asp Ser Ser 35 40 45Ile Arg Ile Ile Pro Val Arg His Glu Ala Asn
Ala Ala Phe Met Ala 50 55 60Ala Ala Val Gly Arg Ile Thr Gly Lys Ala
Gly Val Ala Leu Val Thr65 70 75 80Ser Gly Pro Gly Cys Ser Asn Leu
Ile Thr Gly Met Ala Thr Ala Asn 85 90 95Ser Glu Gly Asp Pro Val Val
Ala Leu Gly Gly Ala Val Lys Arg Ala 100 105 110Asp Lys Ala Lys Gln
Val His Gln Ser Met Asp Thr Val Ala Met Phe 115 120 125Ser Pro Val
Thr Lys Tyr Ala Ile Glu Val Thr Ala Pro Asp Ala Leu 130 135 140Ala
Glu Val Val Ser Asn Ala Phe Arg Ala Ala Glu Gln Gly Arg Pro145 150
155 160Gly Ser Ala Phe Val Ser Leu Pro Gln Asp Val Val Asp Gly Pro
Val 165 170 175Ser Gly Lys Val Leu Pro Ala Ser Gly Ala Pro Gln Met
Gly Ala Ala 180 185 190Pro Asp Asp Ala Ile Asp Gln Val Ala Lys Leu
Ile Ala Gln Ala Lys 195 200 205Asn Pro Ile Phe Leu Leu Gly Leu Met
Ala Ser Gln Pro Glu Asn Ser 210 215 220Lys Ala Leu Arg Arg Leu Leu
Glu Thr Ser His Ile Pro Val Thr Ser225 230 235 240Thr Tyr Gln Ala
Ala Gly Ala Val Asn Gln Asp Asn Phe Ser Arg Phe 245 250 255Ala Gly
Arg Val Gly Leu Phe Asn Asn Gln Ala Gly Asp Arg Leu Leu 260 265
270Gln Leu Ala Asp Leu Val Ile Cys Ile Gly Tyr Ser Pro Val Glu Tyr
275 280 285Glu Pro Ala Met Trp Asn Ser Gly Asn Ala Thr Leu Val His
Ile Asp 290 295 300Val Leu Pro Ala Tyr Glu Glu Arg Asn Tyr Thr Pro
Asp Val Glu Leu305 310 315 320Val Gly Asp Ile Ala Gly Thr Leu Asn
Lys Leu Ala Gln Asn Ile Asp 325 330 335His Arg Leu Val Leu Ser Pro
Gln Ala Ala Glu Ile Leu Arg Asp Arg 340 345 350Gln His Gln Arg Glu
Leu Leu Asp Arg Arg Gly Ala Gln Leu Asn Gln 355 360 365Phe Ala Leu
His Pro Leu Arg Ile Val Arg Ala Met Gln Asp Ile Val 370 375 380Asn
Ser Asp Val Thr Leu Thr Val Asp Met Gly Ser Phe His Ile Trp385 390
395 400Ile Ala Arg Tyr Leu Tyr Thr Phe Arg Ala Arg Gln Val Met Ile
Ser 405 410 415Asn Gly Gln Gln Thr Met Gly Val Ala Leu Pro Trp Ala
Ile Gly Ala 420 425 430Trp Leu Val Asn Pro Glu Arg Lys Val Val Ser
Val Ser Gly Asp Gly 435 440 445Gly Phe Leu Gln Ser Ser Met Glu Leu
Glu Thr Ala Val Arg Leu Lys 450 455 460Ala Asn Val Leu His Leu Ile
Trp Val Asp Asn Gly Tyr Asn Met Val465 470 475 480Ala Ile Gln Glu
Glu Lys Lys Tyr Gln Arg Leu Ser Gly Val Glu Phe 485 490 495Gly Pro
Met Asp Phe Lys Ala Tyr Ala Glu Ser Phe Gly Ala Lys Gly 500 505
510Phe Ala Val Glu Ser Ala Glu Ala Leu Glu Pro Thr Leu Arg Ala Ala
515 520 525Met Asp Val Asp Gly Pro Ala Val Val Ala Ile Pro Val Asp
Tyr Arg 530 535 540Asp Asn Pro Leu Leu Met Gly Gln Leu His Leu Ser
Gln Ile Leu545 550 55531716DNABacillus subtilis 3atgttgacaa
aagcaacaaa agaacaaaaa tcccttgtga aaaacagagg ggcggagctt 60gttgttgatt
gcttagtgga gcaaggtgtc acacatgtat ttggcattcc aggtgcaaaa
120attgatgcgg tatttgacgc tttacaagat aaaggacctg aaattatcgt
tgcccggcac 180gaacaaaacg cagcattcat ggcccaagca gtcggccgtt
taactggaaa accgggagtc 240gtgttagtca catcaggacc gggtgcctct
aacttggcaa caggcctgct gacagcgaac 300actgaaggag accctgtcgt
tgcgcttgct ggaaacgtga tccgtgcaga tcgtttaaaa 360cggacacatc
aatctttgga taatgcggcg ctattccagc cgattacaaa atacagtgta
420gaagttcaag atgtaaaaaa tataccggaa gctgttacaa atgcatttag
gatagcgtca 480gcagggcagg ctggggccgc ttttgtgagc tttccgcaag
atgttgtgaa tgaagtcaca 540aatacgaaaa acgtgcgtgc tgttgcagcg
ccaaaactcg gtcctgcagc agatgatgca 600atcagtgcgg ccatagcaaa
aatccaaaca gcaaaacttc ctgtcgtttt ggtcggcatg 660aaaggcggaa
gaccggaagc aattaaagcg gttcgcaagc ttttgaaaaa ggttcagctt
720ccatttgttg aaacatatca agctgccggt accctttcta gagatttaga
ggatcaatat 780tttggccgta tcggtttgtt ccgcaaccag cctggcgatt
tactgctaga gcaggcagat 840gttgttctga cgatcggcta tgacccgatt
gaatatgatc cgaaattctg gaatatcaat 900ggagaccgga caattatcca
tttagacgag attatcgctg acattgatca tgcttaccag 960cctgatcttg
aattgatcgg tgacattccg tccacgatca atcatatcga acacgatgct
1020gtgaaagtgg aatttgcaga gcgtgagcag aaaatccttt ctgatttaaa
acaatatatg 1080catgaaggtg agcaggtgcc tgcagattgg aaatcagaca
gagcgcaccc tcttgaaatc 1140gttaaagagt tgcgtaatgc agtcgatgat
catgttacag taacttgcga tatcggttcg 1200cacgccattt ggatgtcacg
ttatttccgc agctacgagc cgttaacatt aatgatcagt 1260aacggtatgc
aaacactcgg cgttgcgctt ccttgggcaa tcggcgcttc attggtgaaa
1320ccgggagaaa aagtggtttc tgtctctggt gacggcggtt tcttattctc
agcaatggaa 1380ttagagacag cagttcgact aaaagcacca attgtacaca
ttgtatggaa cgacagcaca 1440tatgacatgg ttgcattcca gcaattgaaa
aaatataacc gtacatctgc ggtcgatttc 1500ggaaatatcg atatcgtgaa
atatgcggaa agcttcggag caactggctt gcgcgtagaa 1560tcaccagacc
agctggcaga tgttctgcgt caaggcatga acgctgaagg tcctgtcatc
1620atcgatgtcc cggttgacta cagtgataac attaatttag caagtgacaa
gcttccgaaa 1680gaattcgggg aactcatgaa aacgaaagct ctctag
17164571PRTBacillus subtilis 4Met Leu Thr Lys Ala Thr Lys Glu Gln
Lys Ser Leu Val Lys Asn Arg1 5 10 15Gly Ala Glu Leu Val Val Asp Cys
Leu Val Glu Gln Gly Val Thr His 20 25 30Val Phe Gly Ile Pro Gly Ala
Lys Ile Asp Ala Val Phe Asp Ala Leu 35 40 45Gln Asp Lys Gly Pro Glu
Ile Ile Val Ala Arg His Glu Gln Asn Ala 50 55 60Ala Phe Met Ala Gln
Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val65 70 75 80Val Leu Val
Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu 85 90 95Leu Thr
Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn 100 105
110Val Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn
115 120 125Ala Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val
Gln Asp 130 135 140Val Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe
Arg Ile Ala Ser145 150 155 160Ala Gly Gln Ala Gly Ala Ala Phe Val
Ser Phe Pro Gln Asp Val Val 165 170 175Asn Glu Val Thr Asn Thr Lys
Asn Val Arg Ala Val Ala Ala Pro Lys 180 185 190Leu Gly Pro Ala Ala
Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile 195 200 205Gln Thr Ala
Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg 210 215 220Pro
Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu225 230
235 240Pro Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp
Leu 245 250 255Glu Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn
Gln Pro Gly 260 265 270Asp Leu Leu Leu Glu Gln Ala Asp Val Val Leu
Thr Ile Gly Tyr Asp 275 280 285Pro Ile Glu Tyr Asp Pro Lys Phe Trp
Asn Ile Asn Gly Asp Arg Thr 290 295 300Ile Ile His Leu Asp Glu Ile
Ile Ala Asp Ile Asp His Ala Tyr Gln305 310 315 320Pro Asp Leu Glu
Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile 325 330 335Glu His
Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile 340 345
350Leu Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala
355 360 365Asp Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys
Glu Leu 370 375 380Arg Asn Ala Val Asp Asp His Val Thr Val Thr Cys
Asp Ile Gly Ser385 390 395 400His Ala Ile Trp Met Ser Arg Tyr Phe
Arg Ser Tyr Glu Pro Leu Thr 405 410 415Leu Met Ile Ser Asn Gly Met
Gln Thr Leu Gly Val Ala Leu Pro Trp 420 425 430Ala Ile Gly Ala Ser
Leu Val Lys Pro Gly Glu Lys Val Val Ser Val 435 440 445Ser Gly Asp
Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala 450 455 460Val
Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr465 470
475 480Tyr Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr
Ser 485 490 495Ala Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala
Glu Ser Phe 500 505 510Gly Ala Thr Gly Leu Arg Val Glu Ser Pro Asp
Gln Leu Ala Asp Val 515 520 525Leu Arg Gln Gly Met Asn Ala Glu Gly
Pro Val Ile Ile Asp Val Pro 530 535 540Val Asp Tyr Ser Asp Asn Ile
Asn Leu Ala Ser Asp Lys Leu Pro Lys545 550 555 560Glu Phe Gly Glu
Leu Met Lys Thr Lys Ala Leu 565 57051665DNALactococcus lactis
5atgtctgaga aacaatttgg ggcgaacttg gttgtcgata gtttgattaa ccataaagtg
60aagtatgtat ttgggattcc aggagcaaaa attgaccggg tttttgattt attagaaaat
120gaagaaggcc ctcaaatggt cgtgactcgt catgagcaag gagctgcttt
catggctcaa 180gctgtcggtc gtttaactgg cgaacctggt gtagtagttg
ttacgagtgg gcctggtgta 240tcaaaccttg cgactccgct tttgaccgcg
acatcagaag gtgatgctat tttggctatc 300ggtggacaag ttaaacgaag
tgaccgtctt aaacgtgcgc accaatcaat ggataatgct 360ggaatgatgc
aatcagcaac aaaatattca gcagaagttc ttgaccctaa tacactttct
420gaatcaattg ccaacgctta tcgtattgca aaatcaggac atccaggtgc
aactttctta 480tcaatccccc aagatgtaac ggatgccgaa gtatcaatca
aagccattca accactttca 540gaccctaaaa tggggaatgc ctctattgat
gacattaatt atttagcaca agcaattaaa 600aatgctgtat tgccagtaat
tttggttgga gctggtgctt cagatgctaa agtcgcttca 660tccttgcgta
atctattgac tcatgttaat attcctgtcg ttgaaacatt ccaaggtgca
720ggggttattt cacatgattt agaacatact ttttatggac gtatcggtct
tttccgcaat 780caaccaggcg atatgcttct gaaacgttct gaccttgtta
ttgctgttgg ttatgaccca 840attgaatatg aagctcgtaa ctggaatgca
gaaattgata gtcgaattat cgttattgat 900aatgccattg ctgaaattga
tacttactac caaccagagc gtgaattaat tggtgatatc 960gcagcaacat
tggataatct tttaccagct gttcgtggct acaaaattcc aaaaggaaca
1020aaagattatc tcgatggcct tcatgaagtt gctgagcaac acgaatttga
tactgaaaat 1080actgaagaag gtagaatgca ccctcttgat ttggtcagca
ctttccaaga aatcgtcaag 1140gatgatgaaa cagtaaccgt tgacgtaggt
tcactctaca tttggatggc acgtcatttc 1200aaatcatacg aaccacgtca
tctcctcttc tcaaacggaa tgcaaacact cggagttgca 1260cttccttggg
caattacagc cgcattgttg cgcccaggta aaaaagttta ttcacactct
1320ggtgatggag gcttcctttt cacagggcaa gaattggaaa cagctgtacg
tttgaatctt 1380ccaatcgttc aaattatctg gaatgacggc cattatgata
tggttaaatt ccaagaagaa 1440atgaaatatg gtcgttcagc agccgttgat
tttggctatg ttgattacgt aaaatatgct 1500gaagcaatga gagcaaaagg
ttaccgtgca cacagcaaag aagaacttgc tgaaattctc 1560aaatcaatcc
cagatactac tggaccggtg gtaattgacg ttcctttgga ctattctgat
1620aacattaaat tagcagaaaa attattgcct gaagagtttt attga
16656554PRTLactococcus lactis 6Met Ser Glu Lys Gln Phe Gly Ala Asn
Leu Val Val Asp Ser Leu Ile1 5 10 15Asn His Lys Val Lys Tyr Val Phe
Gly Ile Pro Gly Ala Lys Ile Asp 20 25 30Arg Val Phe Asp Leu Leu Glu
Asn Glu Glu Gly Pro Gln Met Val Val 35 40 45Thr Arg His Glu Gln Gly
Ala Ala Phe Met Ala Gln Ala Val Gly Arg 50 55 60Leu Thr Gly Glu Pro
Gly Val Val Val Val Thr Ser Gly Pro Gly Val65 70 75 80Ser Asn Leu
Ala Thr Pro Leu Leu Thr Ala Thr Ser Glu Gly Asp Ala 85 90 95Ile Leu
Ala Ile Gly Gly Gln Val Lys Arg Ser Asp Arg Leu Lys Arg 100 105
110Ala His Gln Ser Met Asp Asn Ala Gly Met Met Gln Ser Ala Thr Lys
115 120 125Tyr Ser Ala Glu Val Leu Asp Pro Asn Thr Leu Ser Glu Ser
Ile Ala 130 135 140Asn Ala Tyr Arg Ile Ala Lys Ser Gly His Pro Gly
Ala Thr Phe Leu145 150 155 160Ser Ile Pro Gln Asp Val Thr Asp Ala
Glu Val Ser Ile Lys Ala Ile 165 170 175Gln Pro Leu Ser Asp Pro Lys
Met Gly Asn Ala Ser Ile Asp Asp Ile 180 185 190Asn Tyr Leu Ala Gln
Ala Ile Lys Asn Ala Val Leu Pro Val Ile Leu 195 200 205Val Gly Ala
Gly Ala Ser Asp Ala Lys Val Ala Ser Ser Leu Arg Asn 210 215 220Leu
Leu Thr His Val Asn Ile Pro Val Val Glu Thr Phe Gln Gly Ala225 230
235 240Gly Val Ile Ser His Asp Leu Glu His Thr Phe Tyr Gly Arg Ile
Gly 245 250 255Leu Phe Arg Asn Gln Pro Gly Asp Met Leu Leu Lys Arg
Ser Asp Leu 260 265 270Val Ile Ala Val Gly Tyr Asp Pro Ile Glu Tyr
Glu Ala Arg Asn Trp 275 280 285Asn Ala Glu Ile Asp Ser Arg Ile Ile
Val Ile Asp Asn Ala Ile Ala 290 295 300Glu Ile Asp Thr Tyr Tyr Gln
Pro Glu Arg Glu Leu Ile Gly Asp Ile305 310 315 320Ala Ala Thr Leu
Asp Asn Leu Leu Pro Ala Val Arg Gly Tyr Lys Ile 325 330 335Pro Lys
Gly Thr Lys Asp Tyr Leu Asp Gly Leu His Glu Val Ala Glu 340 345
350Gln His Glu Phe Asp Thr Glu Asn Thr Glu Glu Gly Arg Met His Pro
355 360 365Leu Asp Leu Val Ser Thr Phe Gln Glu Ile Val Lys Asp Asp
Glu Thr 370 375 380Val Thr Val Asp Val Gly Ser Leu Tyr Ile Trp Met
Ala Arg His Phe385 390 395 400Lys Ser Tyr Glu Pro Arg His Leu Leu
Phe Ser Asn Gly Met Gln Thr 405 410 415Leu Gly Val Ala Leu Pro Trp
Ala Ile Thr Ala Ala Leu Leu Arg Pro 420 425 430Gly Lys Lys Val Tyr
Ser His Ser Gly Asp Gly Gly Phe Leu Phe Thr 435 440 445Gly Gln Glu
Leu Glu Thr Ala Val Arg Leu Asn Leu Pro Ile Val Gln 450 455 460Ile
Ile Trp Asn Asp Gly His Tyr Asp Met Val Lys Phe Gln Glu Glu465 470
475 480Met Lys Tyr Gly Arg Ser Ala Ala Val Asp Phe Gly Tyr Val Asp
Tyr
485 490 495Val Lys Tyr Ala Glu Ala Met Arg Ala Lys Gly Tyr Arg Ala
His Ser 500 505 510Lys Glu Glu Leu Ala Glu Ile Leu Lys Ser Ile Pro
Asp Thr Thr Gly 515 520 525Pro Val Val Ile Asp Val Pro Leu Asp Tyr
Ser Asp Asn Ile Lys Leu 530 535 540Ala Glu Lys Leu Leu Pro Glu Glu
Phe Tyr545 55071665DNAStaphylococcus aureusCDS(1)..(1665) 7atg act
gat aaa aag tac act gca gcc gat atg gtt att gat act ttg 48Met Thr
Asp Lys Lys Tyr Thr Ala Ala Asp Met Val Ile Asp Thr Leu1 5 10 15aaa
aat aat ggg gta gaa tat gtt ttt ggt att ccg ggt gca aag ata 96Lys
Asn Asn Gly Val Glu Tyr Val Phe Gly Ile Pro Gly Ala Lys Ile 20 25
30gac tat cta ttt aat gct tta att gat gat ggt cct gaa ctt att gtc
144Asp Tyr Leu Phe Asn Ala Leu Ile Asp Asp Gly Pro Glu Leu Ile Val
35 40 45act cgt cat gaa caa aat gct gca atg atg gca caa ggt att gga
aga 192Thr Arg His Glu Gln Asn Ala Ala Met Met Ala Gln Gly Ile Gly
Arg 50 55 60tta aca ggt aaa ccg ggt gta gta ctt gtt aca agt ggc cct
ggt gta 240Leu Thr Gly Lys Pro Gly Val Val Leu Val Thr Ser Gly Pro
Gly Val65 70 75 80agt aat tta acg act gga cta tta aca gct aca tct
gaa ggg gat cct 288Ser Asn Leu Thr Thr Gly Leu Leu Thr Ala Thr Ser
Glu Gly Asp Pro 85 90 95gta tta gcg tta ggt ggc caa gtg aaa cgt aat
gat tta tta cga tta 336Val Leu Ala Leu Gly Gly Gln Val Lys Arg Asn
Asp Leu Leu Arg Leu 100 105 110acg cat caa agt att gat aat gct gcg
cta tta aaa tat tca tca aaa 384Thr His Gln Ser Ile Asp Asn Ala Ala
Leu Leu Lys Tyr Ser Ser Lys 115 120 125tac agt gaa gaa gta caa gat
cct gaa tca tta tca gaa gtt atg aca 432Tyr Ser Glu Glu Val Gln Asp
Pro Glu Ser Leu Ser Glu Val Met Thr 130 135 140aat gca att cga att
gct act tca gga aaa aat ggc gca agt ttt att 480Asn Ala Ile Arg Ile
Ala Thr Ser Gly Lys Asn Gly Ala Ser Phe Ile145 150 155 160agt att
ccg caa gac gtt att tct tca cca gtt gaa tct aaa gct ata 528Ser Ile
Pro Gln Asp Val Ile Ser Ser Pro Val Glu Ser Lys Ala Ile 165 170
175tca ctt tgc caa aaa cca aat tta gga gta ccg agt gaa caa gat att
576Ser Leu Cys Gln Lys Pro Asn Leu Gly Val Pro Ser Glu Gln Asp Ile
180 185 190aat gat gtc att gaa gcg att aaa aat gca tca ttt cct gtt
tta tta 624Asn Asp Val Ile Glu Ala Ile Lys Asn Ala Ser Phe Pro Val
Leu Leu 195 200 205gct ggt atg aga agt tca agt gca gaa gaa aca aat
gcc att cgc aaa 672Ala Gly Met Arg Ser Ser Ser Ala Glu Glu Thr Asn
Ala Ile Arg Lys 210 215 220tta gtt gag cgc acg aat tta cca gtt gta
gaa aca ttc caa ggt gca 720Leu Val Glu Arg Thr Asn Leu Pro Val Val
Glu Thr Phe Gln Gly Ala225 230 235 240ggt gta att agt cgt gaa tta
gaa aat cat ttc ttc ggt cgt gtg ggc 768Gly Val Ile Ser Arg Glu Leu
Glu Asn His Phe Phe Gly Arg Val Gly 245 250 255tta ttc cgc aat caa
gtt ggt gat gaa tta tta cgt aaa agt gat tta 816Leu Phe Arg Asn Gln
Val Gly Asp Glu Leu Leu Arg Lys Ser Asp Leu 260 265 270gtt gtt aca
atc ggt tat gat cca att gaa tac gaa gct agt aac tgg 864Val Val Thr
Ile Gly Tyr Asp Pro Ile Glu Tyr Glu Ala Ser Asn Trp 275 280 285aat
aaa gaa tta gaa aca caa att atc aat att gac gaa gtt caa gct 912Asn
Lys Glu Leu Glu Thr Gln Ile Ile Asn Ile Asp Glu Val Gln Ala 290 295
300gaa att act aat tat atg caa ccg aaa aaa gag ttg att ggt aat att
960Glu Ile Thr Asn Tyr Met Gln Pro Lys Lys Glu Leu Ile Gly Asn
Ile305 310 315 320gct aaa acg att gaa atg att tct gaa aaa gtg gat
gag cca ttt ata 1008Ala Lys Thr Ile Glu Met Ile Ser Glu Lys Val Asp
Glu Pro Phe Ile 325 330 335aat caa caa cat tta gac gaa tta gaa caa
tta aga aca cat att gat 1056Asn Gln Gln His Leu Asp Glu Leu Glu Gln
Leu Arg Thr His Ile Asp 340 345 350gaa gaa act ggt att aaa gcg acg
cat gaa gaa gga att cta cat cca 1104Glu Glu Thr Gly Ile Lys Ala Thr
His Glu Glu Gly Ile Leu His Pro 355 360 365gtg gaa att att gaa tct
atg caa aag gta tta act gat gat act act 1152Val Glu Ile Ile Glu Ser
Met Gln Lys Val Leu Thr Asp Asp Thr Thr 370 375 380gta aca gtt gat
gtt gga agt cac tat att tgg atg gca cgt aat ttc 1200Val Thr Val Asp
Val Gly Ser His Tyr Ile Trp Met Ala Arg Asn Phe385 390 395 400aga
agt tac aat cca aga cat tta tta ttt agc aat ggt atg caa acg 1248Arg
Ser Tyr Asn Pro Arg His Leu Leu Phe Ser Asn Gly Met Gln Thr 405 410
415ctt ggt gta gca tta ccg tgg gca att tca gct gca ctt gtg cgc cct
1296Leu Gly Val Ala Leu Pro Trp Ala Ile Ser Ala Ala Leu Val Arg Pro
420 425 430aat acg caa gtt gtg tcc gtt gct ggc gat ggt ggc ttt tta
ttt tca 1344Asn Thr Gln Val Val Ser Val Ala Gly Asp Gly Gly Phe Leu
Phe Ser 435 440 445tca caa gat tta gaa acg gcc gta cgt aaa aat tta
aat atc atc cag 1392Ser Gln Asp Leu Glu Thr Ala Val Arg Lys Asn Leu
Asn Ile Ile Gln 450 455 460ctt att tgg aat gat gga aaa tat aac atg
gtt gaa ttc caa gaa gaa 1440Leu Ile Trp Asn Asp Gly Lys Tyr Asn Met
Val Glu Phe Gln Glu Glu465 470 475 480atg aaa tat aaa cgt tcg tca
ggt gta gac ttc ggt cct gta gat ttt 1488Met Lys Tyr Lys Arg Ser Ser
Gly Val Asp Phe Gly Pro Val Asp Phe 485 490 495gta aaa tat gca gaa
tca ttt ggc gcg aaa ggt tta cga gtt act aat 1536Val Lys Tyr Ala Glu
Ser Phe Gly Ala Lys Gly Leu Arg Val Thr Asn 500 505 510caa gaa gaa
tta gaa gcg gca att aaa gag ggc tat gaa aca gat ggt 1584Gln Glu Glu
Leu Glu Ala Ala Ile Lys Glu Gly Tyr Glu Thr Asp Gly 515 520 525cca
gta tta att gat ata cct gta aat tac aaa gat aat atc aaa ctt 1632Pro
Val Leu Ile Asp Ile Pro Val Asn Tyr Lys Asp Asn Ile Lys Leu 530 535
540tca aca aat atg tta cct gac gta ttt aac taa 1665Ser Thr Asn Met
Leu Pro Asp Val Phe Asn545 5508554PRTStaphylococcus aureus 8Met Thr
Asp Lys Lys Tyr Thr Ala Ala Asp Met Val Ile Asp Thr Leu1 5 10 15Lys
Asn Asn Gly Val Glu Tyr Val Phe Gly Ile Pro Gly Ala Lys Ile 20 25
30Asp Tyr Leu Phe Asn Ala Leu Ile Asp Asp Gly Pro Glu Leu Ile Val
35 40 45Thr Arg His Glu Gln Asn Ala Ala Met Met Ala Gln Gly Ile Gly
Arg 50 55 60Leu Thr Gly Lys Pro Gly Val Val Leu Val Thr Ser Gly Pro
Gly Val65 70 75 80Ser Asn Leu Thr Thr Gly Leu Leu Thr Ala Thr Ser
Glu Gly Asp Pro 85 90 95Val Leu Ala Leu Gly Gly Gln Val Lys Arg Asn
Asp Leu Leu Arg Leu 100 105 110Thr His Gln Ser Ile Asp Asn Ala Ala
Leu Leu Lys Tyr Ser Ser Lys 115 120 125Tyr Ser Glu Glu Val Gln Asp
Pro Glu Ser Leu Ser Glu Val Met Thr 130 135 140Asn Ala Ile Arg Ile
Ala Thr Ser Gly Lys Asn Gly Ala Ser Phe Ile145 150 155 160Ser Ile
Pro Gln Asp Val Ile Ser Ser Pro Val Glu Ser Lys Ala Ile 165 170
175Ser Leu Cys Gln Lys Pro Asn Leu Gly Val Pro Ser Glu Gln Asp Ile
180 185 190Asn Asp Val Ile Glu Ala Ile Lys Asn Ala Ser Phe Pro Val
Leu Leu 195 200 205Ala Gly Met Arg Ser Ser Ser Ala Glu Glu Thr Asn
Ala Ile Arg Lys 210 215 220Leu Val Glu Arg Thr Asn Leu Pro Val Val
Glu Thr Phe Gln Gly Ala225 230 235 240Gly Val Ile Ser Arg Glu Leu
Glu Asn His Phe Phe Gly Arg Val Gly 245 250 255Leu Phe Arg Asn Gln
Val Gly Asp Glu Leu Leu Arg Lys Ser Asp Leu 260 265 270Val Val Thr
Ile Gly Tyr Asp Pro Ile Glu Tyr Glu Ala Ser Asn Trp 275 280 285Asn
Lys Glu Leu Glu Thr Gln Ile Ile Asn Ile Asp Glu Val Gln Ala 290 295
300Glu Ile Thr Asn Tyr Met Gln Pro Lys Lys Glu Leu Ile Gly Asn
Ile305 310 315 320Ala Lys Thr Ile Glu Met Ile Ser Glu Lys Val Asp
Glu Pro Phe Ile 325 330 335Asn Gln Gln His Leu Asp Glu Leu Glu Gln
Leu Arg Thr His Ile Asp 340 345 350Glu Glu Thr Gly Ile Lys Ala Thr
His Glu Glu Gly Ile Leu His Pro 355 360 365Val Glu Ile Ile Glu Ser
Met Gln Lys Val Leu Thr Asp Asp Thr Thr 370 375 380Val Thr Val Asp
Val Gly Ser His Tyr Ile Trp Met Ala Arg Asn Phe385 390 395 400Arg
Ser Tyr Asn Pro Arg His Leu Leu Phe Ser Asn Gly Met Gln Thr 405 410
415Leu Gly Val Ala Leu Pro Trp Ala Ile Ser Ala Ala Leu Val Arg Pro
420 425 430Asn Thr Gln Val Val Ser Val Ala Gly Asp Gly Gly Phe Leu
Phe Ser 435 440 445Ser Gln Asp Leu Glu Thr Ala Val Arg Lys Asn Leu
Asn Ile Ile Gln 450 455 460Leu Ile Trp Asn Asp Gly Lys Tyr Asn Met
Val Glu Phe Gln Glu Glu465 470 475 480Met Lys Tyr Lys Arg Ser Ser
Gly Val Asp Phe Gly Pro Val Asp Phe 485 490 495Val Lys Tyr Ala Glu
Ser Phe Gly Ala Lys Gly Leu Arg Val Thr Asn 500 505 510Gln Glu Glu
Leu Glu Ala Ala Ile Lys Glu Gly Tyr Glu Thr Asp Gly 515 520 525Pro
Val Leu Ile Asp Ile Pro Val Asn Tyr Lys Asp Asn Ile Lys Leu 530 535
540Ser Thr Asn Met Leu Pro Asp Val Phe Asn545 55091698DNAListeria
monocytogenesCDS(1)..(1698) 9atg gcg aaa cta gaa aaa gac caa gaa
aaa gta ata aca caa ggg aaa 48Met Ala Lys Leu Glu Lys Asp Gln Glu
Lys Val Ile Thr Gln Gly Lys1 5 10 15tca gga gcg gat tta gtt gta gac
agc tta att aat caa ggt gtt acg 96Ser Gly Ala Asp Leu Val Val Asp
Ser Leu Ile Asn Gln Gly Val Thr 20 25 30cat gta ttc ggg att ccg gga
gcg aaa att gat aaa gtt ttt gat gtg 144His Val Phe Gly Ile Pro Gly
Ala Lys Ile Asp Lys Val Phe Asp Val 35 40 45atg gaa gaa cgt gga cca
gaa tta att gtc agt cgt cat gaa caa aat 192Met Glu Glu Arg Gly Pro
Glu Leu Ile Val Ser Arg His Glu Gln Asn 50 55 60gcg gcg ttt atg gct
gct gct atc ggt cgt cta acc ggg aaa cct ggt 240Ala Ala Phe Met Ala
Ala Ala Ile Gly Arg Leu Thr Gly Lys Pro Gly65 70 75 80gtt gta ctt
gta act agt gga cct ggc gca tcg aat ctt gca aca ggg 288Val Val Leu
Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly 85 90 95ctt gta
acc gca act gca gaa gga gat cca gtc gtt gcg att gct ggt 336Leu Val
Thr Ala Thr Ala Glu Gly Asp Pro Val Val Ala Ile Ala Gly 100 105
110aac gta aca agg caa gac cgc tta aaa aga acc cac caa tca atg gat
384Asn Val Thr Arg Gln Asp Arg Leu Lys Arg Thr His Gln Ser Met Asp
115 120 125aat gca gca ctt ttc cgt ccg att aca aaa tac agc gaa gaa
gta gtt 432Asn Ala Ala Leu Phe Arg Pro Ile Thr Lys Tyr Ser Glu Glu
Val Val 130 135 140cac gcc gaa agt att cca gaa gca atc act aac gct
ttt cgc tcg gca 480His Ala Glu Ser Ile Pro Glu Ala Ile Thr Asn Ala
Phe Arg Ser Ala145 150 155 160aca gaa cca aac caa ggc gct gct ttt
gtc agt ttg cca caa gat atc 528Thr Glu Pro Asn Gln Gly Ala Ala Phe
Val Ser Leu Pro Gln Asp Ile 165 170 175gtg aac gaa cca aac gta cca
gta aaa gcg att cgc cca ctt gct aaa 576Val Asn Glu Pro Asn Val Pro
Val Lys Ala Ile Arg Pro Leu Ala Lys 180 185 190cca gaa aat ggt cct
gct tcc aaa gaa caa gtt gca aaa ctt gtt aca 624Pro Glu Asn Gly Pro
Ala Ser Lys Glu Gln Val Ala Lys Leu Val Thr 195 200 205cgt ttg aaa
aaa gcg aaa tta ccg gta ttg cta ttg ggt atg cga gca 672Arg Leu Lys
Lys Ala Lys Leu Pro Val Leu Leu Leu Gly Met Arg Ala 210 215 220tct
agt cca gaa gta act ggt gca att cgt cgc tta ctc caa aaa aca 720Ser
Ser Pro Glu Val Thr Gly Ala Ile Arg Arg Leu Leu Gln Lys Thr225 230
235 240agt atc cca gta gta gaa act ttc caa gca gct ggc gtc att tca
cgc 768Ser Ile Pro Val Val Glu Thr Phe Gln Ala Ala Gly Val Ile Ser
Arg 245 250 255gac tta gaa gat aac ttc ttt gga cgt gtt ggt ctg ttc
cgc aac caa 816Asp Leu Glu Asp Asn Phe Phe Gly Arg Val Gly Leu Phe
Arg Asn Gln 260 265 270cca ggg gat att ttg tta aat aaa gct gat tta
gtt att aca gtg ggt 864Pro Gly Asp Ile Leu Leu Asn Lys Ala Asp Leu
Val Ile Thr Val Gly 275 280 285tat gat cca att gaa tac gat cca aaa
gct tgg aat gcc tct ggt gat 912Tyr Asp Pro Ile Glu Tyr Asp Pro Lys
Ala Trp Asn Ala Ser Gly Asp 290 295 300aga acg att gtc cat tta gac
gac att cgc gct gat att gat cat tat 960Arg Thr Ile Val His Leu Asp
Asp Ile Arg Ala Asp Ile Asp His Tyr305 310 315 320tac caa cca gtg
aca gag cta gtc gga aac atc gcg ctt act tta gac 1008Tyr Gln Pro Val
Thr Glu Leu Val Gly Asn Ile Ala Leu Thr Leu Asp 325 330 335cga gtg
aat gcg aaa ttc agc ggt tta gaa tta gcg gaa aaa gaa ctt 1056Arg Val
Asn Ala Lys Phe Ser Gly Leu Glu Leu Ala Glu Lys Glu Leu 340 345
350gaa aca tta aaa gaa ctt cat gct caa tta gaa gag cga gat gtt ccg
1104Glu Thr Leu Lys Glu Leu His Ala Gln Leu Glu Glu Arg Asp Val Pro
355 360 365cca gaa agt gat gaa act aac cga gta cat cca ttg tcg gtc
att caa 1152Pro Glu Ser Asp Glu Thr Asn Arg Val His Pro Leu Ser Val
Ile Gln 370 375 380aca cta cgt tcg gca att gat gac aac gta act gtg
aca gtc gac gtt 1200Thr Leu Arg Ser Ala Ile Asp Asp Asn Val Thr Val
Thr Val Asp Val385 390 395 400ggt tca cat tat att tgg atg gca cgt
cat ttc cgc tcc tat gaa cca 1248Gly Ser His Tyr Ile Trp Met Ala Arg
His Phe Arg Ser Tyr Glu Pro 405 410 415cgc cgt ctg ctt ttc agt aac
ggt atg caa acg ctt ggt gtt gcg ctt 1296Arg Arg Leu Leu Phe Ser Asn
Gly Met Gln Thr Leu Gly Val Ala Leu 420 425 430cct tgg gga att gct
gca aca ctt gta cat ccg ggt gaa aaa gtg gtt 1344Pro Trp Gly Ile Ala
Ala Thr Leu Val His Pro Gly Glu Lys Val Val 435 440 445tcg att tct
ggt gac ggt ggt ttc tta ttt tcc gcg atg gaa tta gaa 1392Ser Ile Ser
Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu 450 455 460aca
gct gtc cgc ttg cgt gcg cca ctt gta cac cta gta tgg aat gac 1440Thr
Ala Val Arg Leu Arg Ala Pro Leu Val His Leu Val Trp Asn Asp465 470
475 480gga agc tat gac atg gtt gct ttc caa caa aaa atg aaa tac ggc
aaa 1488Gly Ser Tyr Asp Met Val Ala Phe Gln Gln Lys Met Lys Tyr Gly
Lys 485 490 495gaa gca gct gtt cgt ttt ggc gat gtt gat atc gta aaa
ttt gca gaa 1536Glu Ala Ala Val Arg Phe Gly Asp Val Asp Ile Val Lys
Phe Ala Glu 500 505 510agt ttc gga gca aaa ggt ctt cgc gta aca aat
cca gca gaa ctt tct 1584Ser Phe Gly Ala Lys Gly Leu Arg Val Thr Asn
Pro Ala Glu Leu Ser 515 520 525gat gtg tta aaa gaa gcg ctt gaa aca
gaa gga ccc gtc gtt gta gat 1632Asp Val Leu Lys Glu Ala Leu Glu Thr
Glu Gly Pro Val Val Val Asp 530 535 540att cca att gat tac cgt gat
aac atc aaa ctt ggc gaa act tta cta 1680Ile Pro Ile Asp Tyr Arg Asp
Asn Ile Lys Leu Gly Glu Thr Leu Leu545 550 555 560cct gac caa ttt
tat taa 1698Pro Asp Gln Phe Tyr 56510565PRTListeria monocytogenes
10Met Ala Lys Leu Glu Lys Asp Gln Glu Lys Val Ile Thr Gln Gly Lys1
5 10 15Ser Gly Ala Asp Leu Val Val Asp Ser Leu Ile Asn Gln Gly Val
Thr 20 25 30His Val Phe Gly
Ile Pro Gly Ala Lys Ile Asp Lys Val Phe Asp Val 35 40 45Met Glu Glu
Arg Gly Pro Glu Leu Ile Val Ser Arg His Glu Gln Asn 50 55 60Ala Ala
Phe Met Ala Ala Ala Ile Gly Arg Leu Thr Gly Lys Pro Gly65 70 75
80Val Val Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly
85 90 95Leu Val Thr Ala Thr Ala Glu Gly Asp Pro Val Val Ala Ile Ala
Gly 100 105 110Asn Val Thr Arg Gln Asp Arg Leu Lys Arg Thr His Gln
Ser Met Asp 115 120 125Asn Ala Ala Leu Phe Arg Pro Ile Thr Lys Tyr
Ser Glu Glu Val Val 130 135 140His Ala Glu Ser Ile Pro Glu Ala Ile
Thr Asn Ala Phe Arg Ser Ala145 150 155 160Thr Glu Pro Asn Gln Gly
Ala Ala Phe Val Ser Leu Pro Gln Asp Ile 165 170 175Val Asn Glu Pro
Asn Val Pro Val Lys Ala Ile Arg Pro Leu Ala Lys 180 185 190Pro Glu
Asn Gly Pro Ala Ser Lys Glu Gln Val Ala Lys Leu Val Thr 195 200
205Arg Leu Lys Lys Ala Lys Leu Pro Val Leu Leu Leu Gly Met Arg Ala
210 215 220Ser Ser Pro Glu Val Thr Gly Ala Ile Arg Arg Leu Leu Gln
Lys Thr225 230 235 240Ser Ile Pro Val Val Glu Thr Phe Gln Ala Ala
Gly Val Ile Ser Arg 245 250 255Asp Leu Glu Asp Asn Phe Phe Gly Arg
Val Gly Leu Phe Arg Asn Gln 260 265 270Pro Gly Asp Ile Leu Leu Asn
Lys Ala Asp Leu Val Ile Thr Val Gly 275 280 285Tyr Asp Pro Ile Glu
Tyr Asp Pro Lys Ala Trp Asn Ala Ser Gly Asp 290 295 300Arg Thr Ile
Val His Leu Asp Asp Ile Arg Ala Asp Ile Asp His Tyr305 310 315
320Tyr Gln Pro Val Thr Glu Leu Val Gly Asn Ile Ala Leu Thr Leu Asp
325 330 335Arg Val Asn Ala Lys Phe Ser Gly Leu Glu Leu Ala Glu Lys
Glu Leu 340 345 350Glu Thr Leu Lys Glu Leu His Ala Gln Leu Glu Glu
Arg Asp Val Pro 355 360 365Pro Glu Ser Asp Glu Thr Asn Arg Val His
Pro Leu Ser Val Ile Gln 370 375 380Thr Leu Arg Ser Ala Ile Asp Asp
Asn Val Thr Val Thr Val Asp Val385 390 395 400Gly Ser His Tyr Ile
Trp Met Ala Arg His Phe Arg Ser Tyr Glu Pro 405 410 415Arg Arg Leu
Leu Phe Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu 420 425 430Pro
Trp Gly Ile Ala Ala Thr Leu Val His Pro Gly Glu Lys Val Val 435 440
445Ser Ile Ser Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu
450 455 460Thr Ala Val Arg Leu Arg Ala Pro Leu Val His Leu Val Trp
Asn Asp465 470 475 480Gly Ser Tyr Asp Met Val Ala Phe Gln Gln Lys
Met Lys Tyr Gly Lys 485 490 495Glu Ala Ala Val Arg Phe Gly Asp Val
Asp Ile Val Lys Phe Ala Glu 500 505 510Ser Phe Gly Ala Lys Gly Leu
Arg Val Thr Asn Pro Ala Glu Leu Ser 515 520 525Asp Val Leu Lys Glu
Ala Leu Glu Thr Glu Gly Pro Val Val Val Asp 530 535 540Ile Pro Ile
Asp Tyr Arg Asp Asn Ile Lys Leu Gly Glu Thr Leu Leu545 550 555
560Pro Asp Gln Phe Tyr 565111680DNAStreptococcus
mutansCDS(1)..(1680) 11atg acc gaa ata aat aag gaa ggc tat ggg gct
gac ctg att gta gac 48Met Thr Glu Ile Asn Lys Glu Gly Tyr Gly Ala
Asp Leu Ile Val Asp1 5 10 15agc ctc att aat cat gat gtc aac tat gtt
ttt gga atc cct ggt gca 96Ser Leu Ile Asn His Asp Val Asn Tyr Val
Phe Gly Ile Pro Gly Ala 20 25 30aaa att gat cgt gtc ttt gat acc tta
gaa gat aag ggg cca gaa ctt 144Lys Ile Asp Arg Val Phe Asp Thr Leu
Glu Asp Lys Gly Pro Glu Leu 35 40 45att gta gca cgc cat gag caa aat
gct gct ttt atg gct caa gga att 192Ile Val Ala Arg His Glu Gln Asn
Ala Ala Phe Met Ala Gln Gly Ile 50 55 60ggc cgt att act ggt gag cct
ggt gtt gtg att aca acc agc ggt ccc 240Gly Arg Ile Thr Gly Glu Pro
Gly Val Val Ile Thr Thr Ser Gly Pro65 70 75 80ggt gtt tcc aat ctg
gtg act ggt ctt gtt act gcg aca gct gag gga 288Gly Val Ser Asn Leu
Val Thr Gly Leu Val Thr Ala Thr Ala Glu Gly 85 90 95gat cct gtc ctt
gct att ggt ggt cag gtt aaa cgt gct gat ttg ctc 336Asp Pro Val Leu
Ala Ile Gly Gly Gln Val Lys Arg Ala Asp Leu Leu 100 105 110aaa cgg
gct cac cag tca atg aat aat gtt gct atg ctc gat ccc att 384Lys Arg
Ala His Gln Ser Met Asn Asn Val Ala Met Leu Asp Pro Ile 115 120
125acc aaa tat tca gca gaa att cag gat ccc gca aca ctt tca gaa aat
432Thr Lys Tyr Ser Ala Glu Ile Gln Asp Pro Ala Thr Leu Ser Glu Asn
130 135 140att gct aat gcc tat cgt ttg gct aaa gca gga aag ccg gga
gct agt 480Ile Ala Asn Ala Tyr Arg Leu Ala Lys Ala Gly Lys Pro Gly
Ala Ser145 150 155 160ttc tta tct att cct caa gat ata act gat agt
cct gtt act gtc aag 528Phe Leu Ser Ile Pro Gln Asp Ile Thr Asp Ser
Pro Val Thr Val Lys 165 170 175gcg att aag ccc ttg aca gat cct aaa
cta ggt tca gcg tca gtt gct 576Ala Ile Lys Pro Leu Thr Asp Pro Lys
Leu Gly Ser Ala Ser Val Ala 180 185 190gat att aat tat ttg gca cag
gcc ata aaa aat gcg gtc ctt cct gtc 624Asp Ile Asn Tyr Leu Ala Gln
Ala Ile Lys Asn Ala Val Leu Pro Val 195 200 205tta ctt tta gga aat
ggt gcg tca acg gct gca gtt aca gct tct att 672Leu Leu Leu Gly Asn
Gly Ala Ser Thr Ala Ala Val Thr Ala Ser Ile 210 215 220cgc cgt ttg
tta gga gct gtc aag ctg cca gtc gtt gaa act ttc caa 720Arg Arg Leu
Leu Gly Ala Val Lys Leu Pro Val Val Glu Thr Phe Gln225 230 235
240gga gct ggt att gtt tca aga gat tta gaa gag gac act ttt ttt ggt
768Gly Ala Gly Ile Val Ser Arg Asp Leu Glu Glu Asp Thr Phe Phe Gly
245 250 255cgt gtg ggg ctt ttt cgt aat cag ccc gga gat atg ttg ctg
aag cgt 816Arg Val Gly Leu Phe Arg Asn Gln Pro Gly Asp Met Leu Leu
Lys Arg 260 265 270tct gac tta gtt atc gct att ggc tat gat cct att
gaa tat gaa gcg 864Ser Asp Leu Val Ile Ala Ile Gly Tyr Asp Pro Ile
Glu Tyr Glu Ala 275 280 285cgc aat tgg aat gct gaa att tcg gct cgc
att atc gtt att gat gtt 912Arg Asn Trp Asn Ala Glu Ile Ser Ala Arg
Ile Ile Val Ile Asp Val 290 295 300gct cca gct gaa att gat act tat
ttc caa cct gaa cgt gaa tta att 960Ala Pro Ala Glu Ile Asp Thr Tyr
Phe Gln Pro Glu Arg Glu Leu Ile305 310 315 320ggt gat ata gct gaa
aca ctt gat tta ctc cta cct gct att agt ggc 1008Gly Asp Ile Ala Glu
Thr Leu Asp Leu Leu Leu Pro Ala Ile Ser Gly 325 330 335tac tca ctt
cca aaa ggt tct ctt gac tat ctc aaa ggc ctt cgt gat 1056Tyr Ser Leu
Pro Lys Gly Ser Leu Asp Tyr Leu Lys Gly Leu Arg Asp 340 345 350aat
gta gta gaa gat gtc aaa ttt gat aag aca gtc aaa tcc ggt ctg 1104Asn
Val Val Glu Asp Val Lys Phe Asp Lys Thr Val Lys Ser Gly Leu 355 360
365gtt cat ccg ctt gat gtg att gat gtc ctt caa aag caa acg act gat
1152Val His Pro Leu Asp Val Ile Asp Val Leu Gln Lys Gln Thr Thr Asp
370 375 380gat atg aca gta acg gtt gat gtt ggc agc cat tat att tgg
atg gct 1200Asp Met Thr Val Thr Val Asp Val Gly Ser His Tyr Ile Trp
Met Ala385 390 395 400cgt tat ttt aaa agc tat gaa gca cgg cac tta
ctt ttc tca aat ggt 1248Arg Tyr Phe Lys Ser Tyr Glu Ala Arg His Leu
Leu Phe Ser Asn Gly 405 410 415atg caa acc tta ggt gtt gct ttg cct
tgg gca att tcg gca gct ctt 1296Met Gln Thr Leu Gly Val Ala Leu Pro
Trp Ala Ile Ser Ala Ala Leu 420 425 430gta cgg cca aat gag aag att
att tct att tca ggt gat ggt ggt ttc 1344Val Arg Pro Asn Glu Lys Ile
Ile Ser Ile Ser Gly Asp Gly Gly Phe 435 440 445ctc ttt tct ggc caa
gaa ttg gaa aca gct gtt cgt tta cat tta cca 1392Leu Phe Ser Gly Gln
Glu Leu Glu Thr Ala Val Arg Leu His Leu Pro 450 455 460att gtt cat
atc att tgg aat gat ggt aaa tat aat atg gtt gaa ttc 1440Ile Val His
Ile Ile Trp Asn Asp Gly Lys Tyr Asn Met Val Glu Phe465 470 475
480caa gaa gaa atg aaa tac ggc cgt tca gca ggt gtt gat ttt ggt cct
1488Gln Glu Glu Met Lys Tyr Gly Arg Ser Ala Gly Val Asp Phe Gly Pro
485 490 495gtt gat ttt gtc aag tat gct gat agt ttc ggt gct aaa ggt
tac cgt 1536Val Asp Phe Val Lys Tyr Ala Asp Ser Phe Gly Ala Lys Gly
Tyr Arg 500 505 510gct gat agt aaa gaa aag ttt gat caa gtt ctt caa
aca gca ctc aag 1584Ala Asp Ser Lys Glu Lys Phe Asp Gln Val Leu Gln
Thr Ala Leu Lys 515 520 525gaa gct gca aat ggc cca gtt ctc att gat
gtt cca atg gac tat aaa 1632Glu Ala Ala Asn Gly Pro Val Leu Ile Asp
Val Pro Met Asp Tyr Lys 530 535 540gat aat gta aaa ttg ggt gaa act
att ttg cct gat gaa ttc tac taa 1680Asp Asn Val Lys Leu Gly Glu Thr
Ile Leu Pro Asp Glu Phe Tyr545 550 55512559PRTStreptococcus mutans
12Met Thr Glu Ile Asn Lys Glu Gly Tyr Gly Ala Asp Leu Ile Val Asp1
5 10 15Ser Leu Ile Asn His Asp Val Asn Tyr Val Phe Gly Ile Pro Gly
Ala 20 25 30Lys Ile Asp Arg Val Phe Asp Thr Leu Glu Asp Lys Gly Pro
Glu Leu 35 40 45Ile Val Ala Arg His Glu Gln Asn Ala Ala Phe Met Ala
Gln Gly Ile 50 55 60Gly Arg Ile Thr Gly Glu Pro Gly Val Val Ile Thr
Thr Ser Gly Pro65 70 75 80Gly Val Ser Asn Leu Val Thr Gly Leu Val
Thr Ala Thr Ala Glu Gly 85 90 95Asp Pro Val Leu Ala Ile Gly Gly Gln
Val Lys Arg Ala Asp Leu Leu 100 105 110Lys Arg Ala His Gln Ser Met
Asn Asn Val Ala Met Leu Asp Pro Ile 115 120 125Thr Lys Tyr Ser Ala
Glu Ile Gln Asp Pro Ala Thr Leu Ser Glu Asn 130 135 140Ile Ala Asn
Ala Tyr Arg Leu Ala Lys Ala Gly Lys Pro Gly Ala Ser145 150 155
160Phe Leu Ser Ile Pro Gln Asp Ile Thr Asp Ser Pro Val Thr Val Lys
165 170 175Ala Ile Lys Pro Leu Thr Asp Pro Lys Leu Gly Ser Ala Ser
Val Ala 180 185 190Asp Ile Asn Tyr Leu Ala Gln Ala Ile Lys Asn Ala
Val Leu Pro Val 195 200 205Leu Leu Leu Gly Asn Gly Ala Ser Thr Ala
Ala Val Thr Ala Ser Ile 210 215 220Arg Arg Leu Leu Gly Ala Val Lys
Leu Pro Val Val Glu Thr Phe Gln225 230 235 240Gly Ala Gly Ile Val
Ser Arg Asp Leu Glu Glu Asp Thr Phe Phe Gly 245 250 255Arg Val Gly
Leu Phe Arg Asn Gln Pro Gly Asp Met Leu Leu Lys Arg 260 265 270Ser
Asp Leu Val Ile Ala Ile Gly Tyr Asp Pro Ile Glu Tyr Glu Ala 275 280
285Arg Asn Trp Asn Ala Glu Ile Ser Ala Arg Ile Ile Val Ile Asp Val
290 295 300Ala Pro Ala Glu Ile Asp Thr Tyr Phe Gln Pro Glu Arg Glu
Leu Ile305 310 315 320Gly Asp Ile Ala Glu Thr Leu Asp Leu Leu Leu
Pro Ala Ile Ser Gly 325 330 335Tyr Ser Leu Pro Lys Gly Ser Leu Asp
Tyr Leu Lys Gly Leu Arg Asp 340 345 350Asn Val Val Glu Asp Val Lys
Phe Asp Lys Thr Val Lys Ser Gly Leu 355 360 365Val His Pro Leu Asp
Val Ile Asp Val Leu Gln Lys Gln Thr Thr Asp 370 375 380Asp Met Thr
Val Thr Val Asp Val Gly Ser His Tyr Ile Trp Met Ala385 390 395
400Arg Tyr Phe Lys Ser Tyr Glu Ala Arg His Leu Leu Phe Ser Asn Gly
405 410 415Met Gln Thr Leu Gly Val Ala Leu Pro Trp Ala Ile Ser Ala
Ala Leu 420 425 430Val Arg Pro Asn Glu Lys Ile Ile Ser Ile Ser Gly
Asp Gly Gly Phe 435 440 445Leu Phe Ser Gly Gln Glu Leu Glu Thr Ala
Val Arg Leu His Leu Pro 450 455 460Ile Val His Ile Ile Trp Asn Asp
Gly Lys Tyr Asn Met Val Glu Phe465 470 475 480Gln Glu Glu Met Lys
Tyr Gly Arg Ser Ala Gly Val Asp Phe Gly Pro 485 490 495Val Asp Phe
Val Lys Tyr Ala Asp Ser Phe Gly Ala Lys Gly Tyr Arg 500 505 510Ala
Asp Ser Lys Glu Lys Phe Asp Gln Val Leu Gln Thr Ala Leu Lys 515 520
525Glu Ala Ala Asn Gly Pro Val Leu Ile Asp Val Pro Met Asp Tyr Lys
530 535 540Asp Asn Val Lys Leu Gly Glu Thr Ile Leu Pro Asp Glu Phe
Tyr545 550 555131683DNAStreptococcus thermophilusCDS(1)..(1683)
13gtg ttc atg tca gaa gaa aag caa ttg tat ggt gca gat tta gtg gtt
48Val Phe Met Ser Glu Glu Lys Gln Leu Tyr Gly Ala Asp Leu Val Val1
5 10 15gat agt ttg atc aac cat gat gtt gag tat gtc ttt ggg att cca
ggc 96Asp Ser Leu Ile Asn His Asp Val Glu Tyr Val Phe Gly Ile Pro
Gly 20 25 30gca aaa atc gat agg gtt ttt gat acc ttg gaa gat aag gga
cct gaa 144Ala Lys Ile Asp Arg Val Phe Asp Thr Leu Glu Asp Lys Gly
Pro Glu 35 40 45ttg att gtt gcc cgt cat gag caa aat gct gct ttt atg
gct caa ggt 192Leu Ile Val Ala Arg His Glu Gln Asn Ala Ala Phe Met
Ala Gln Gly 50 55 60gtt gga cgt att act ggg aaa cca ggt gta gta ttg
gta aca tct ggt 240Val Gly Arg Ile Thr Gly Lys Pro Gly Val Val Leu
Val Thr Ser Gly65 70 75 80cca ggt gtc tcc aat ttg gct act ggt ttg
gta aca gcg acg gat gaa 288Pro Gly Val Ser Asn Leu Ala Thr Gly Leu
Val Thr Ala Thr Asp Glu 85 90 95gga gac cct gtt ctt gct att ggt ggt
cag gtt aag cgt gca gat ctc 336Gly Asp Pro Val Leu Ala Ile Gly Gly
Gln Val Lys Arg Ala Asp Leu 100 105 110ttg aaa cgt gcc cac caa tca
atg aat aac gtt gct atg ctt gag cca 384Leu Lys Arg Ala His Gln Ser
Met Asn Asn Val Ala Met Leu Glu Pro 115 120 125att acc aaa tat gct
gct gaa gta cat gat gct aac acc ctt tct gaa 432Ile Thr Lys Tyr Ala
Ala Glu Val His Asp Ala Asn Thr Leu Ser Glu 130 135 140acg gtt gct
aat gcc tat cgt cac gct aag tca ggg aaa cca ggt gca 480Thr Val Ala
Asn Ala Tyr Arg His Ala Lys Ser Gly Lys Pro Gly Ala145 150 155
160agc ttc att tca att cct caa gac gtg acg gat gct ccg gtc agt gtt
528Ser Phe Ile Ser Ile Pro Gln Asp Val Thr Asp Ala Pro Val Ser Val
165 170 175aag gct att aag cct atg aca gat cca aaa ctt ggt tca gca
tct gtt 576Lys Ala Ile Lys Pro Met Thr Asp Pro Lys Leu Gly Ser Ala
Ser Val 180 185 190tct gat att aac tat cta gca caa gcc att aaa aat
gca gtg ttg cca 624Ser Asp Ile Asn Tyr Leu Ala Gln Ala Ile Lys Asn
Ala Val Leu Pro 195 200 205gtc ttt ctt ttg ggg aat ggt gcc tca tca
gaa gcc gta act tac tct 672Val Phe Leu Leu Gly Asn Gly Ala Ser Ser
Glu Ala Val Thr Tyr Ser 210 215 220att cgc caa att ttg aag cat gtt
aaa ttg cca gtt gtt gaa act ttc 720Ile Arg Gln Ile Leu Lys His Val
Lys Leu Pro Val Val Glu Thr Phe225 230 235 240caa ggt gcc ggt atc
gtg tca cgt gac ctt gaa gaa gat act ttc ttt 768Gln Gly Ala Gly Ile
Val Ser Arg Asp Leu Glu Glu Asp Thr Phe Phe 245 250 255ggt cgt gta
ggt ctt ttc cgt aac caa ccc gga gac atg ttg ctt aaa 816Gly Arg Val
Gly Leu Phe Arg Asn Gln Pro Gly Asp Met Leu Leu Lys 260 265 270aaa
tcc gac tta gtt att gcc att ggt tat gat cca atc gaa tat gaa 864Lys
Ser Asp Leu Val Ile Ala Ile Gly Tyr Asp Pro Ile Glu Tyr Glu 275 280
285gca cgt aac tgg aat gct gaa att tca gca cgt atc atc gtt att gat
912Ala Arg Asn Trp Asn Ala Glu
Ile Ser Ala Arg Ile Ile Val Ile Asp 290 295 300gtc gag ccg gcc gag
gtg gac act tac ttc caa ccg gaa cgt gaa ttg 960Val Glu Pro Ala Glu
Val Asp Thr Tyr Phe Gln Pro Glu Arg Glu Leu305 310 315 320att ggt
aat gta gaa gcg agc tta gac ttg ctt ttg ccc gct att caa 1008Ile Gly
Asn Val Glu Ala Ser Leu Asp Leu Leu Leu Pro Ala Ile Gln 325 330
335ggt tat aaa ttg cct gaa ggt gcg gtt gaa tat ctt aaa ggt ttg aaa
1056Gly Tyr Lys Leu Pro Glu Gly Ala Val Glu Tyr Leu Lys Gly Leu Lys
340 345 350aac aat gtt gtt gag gat gtt aag ttt gac cgt cag cct gat
gaa ggt 1104Asn Asn Val Val Glu Asp Val Lys Phe Asp Arg Gln Pro Asp
Glu Gly 355 360 365acg gtg cat ccg cta gat ttc atc gaa aat ttg caa
gaa cac aca gat 1152Thr Val His Pro Leu Asp Phe Ile Glu Asn Leu Gln
Glu His Thr Asp 370 375 380gat gat atg act gtt acg ttt gat gtt ggt
agt cac tat att tgg atg 1200Asp Asp Met Thr Val Thr Phe Asp Val Gly
Ser His Tyr Ile Trp Met385 390 395 400gca cgt tat ctc aaa tcg tat
gaa cca cgt cat ttg ctt ttc tca aat 1248Ala Arg Tyr Leu Lys Ser Tyr
Glu Pro Arg His Leu Leu Phe Ser Asn 405 410 415ggg atg caa acg ata
ggt att gct att aca tgg gct atc tct gca gca 1296Gly Met Gln Thr Ile
Gly Ile Ala Ile Thr Trp Ala Ile Ser Ala Ala 420 425 430ttg gtt cgt
cct aag aca aaa gtg att tct gta tct ggt gat ggt ggt 1344Leu Val Arg
Pro Lys Thr Lys Val Ile Ser Val Ser Gly Asp Gly Gly 435 440 445ttc
ctc ttc tca gca caa gaa ttg gaa aca gca gtt cgt ttg aaa ttg 1392Phe
Leu Phe Ser Ala Gln Glu Leu Glu Thr Ala Val Arg Leu Lys Leu 450 455
460cca att gtc cat att atc tgg aac gat ggt cat tac aat atg gtg gaa
1440Pro Ile Val His Ile Ile Trp Asn Asp Gly His Tyr Asn Met Val
Glu465 470 475 480ttc cag gaa gaa atg aag tac ggt cgt tca tct ggg
gtt gac ttt ggt 1488Phe Gln Glu Glu Met Lys Tyr Gly Arg Ser Ser Gly
Val Asp Phe Gly 485 490 495cct gta gat ttt gta aaa tat gct gag agc
ttt gga gcc aaa ggt tat 1536Pro Val Asp Phe Val Lys Tyr Ala Glu Ser
Phe Gly Ala Lys Gly Tyr 500 505 510cgt gca aca agt aaa gca gcg ttt
gct agc ttg ctt caa gag gct ttg 1584Arg Ala Thr Ser Lys Ala Ala Phe
Ala Ser Leu Leu Gln Glu Ala Leu 515 520 525act cag gct gta gat gga
cca gtc ctt att gat gtt cca att gac tat 1632Thr Gln Ala Val Asp Gly
Pro Val Leu Ile Asp Val Pro Ile Asp Tyr 530 535 540aaa gat aac att
aaa ctc ggc gaa act att ttg cca gat gaa ttt tac 1680Lys Asp Asn Ile
Lys Leu Gly Glu Thr Ile Leu Pro Asp Glu Phe Tyr545 550 555 560taa
168314560PRTStreptococcus thermophilus 14Val Phe Met Ser Glu Glu
Lys Gln Leu Tyr Gly Ala Asp Leu Val Val1 5 10 15Asp Ser Leu Ile Asn
His Asp Val Glu Tyr Val Phe Gly Ile Pro Gly 20 25 30Ala Lys Ile Asp
Arg Val Phe Asp Thr Leu Glu Asp Lys Gly Pro Glu 35 40 45Leu Ile Val
Ala Arg His Glu Gln Asn Ala Ala Phe Met Ala Gln Gly 50 55 60Val Gly
Arg Ile Thr Gly Lys Pro Gly Val Val Leu Val Thr Ser Gly65 70 75
80Pro Gly Val Ser Asn Leu Ala Thr Gly Leu Val Thr Ala Thr Asp Glu
85 90 95Gly Asp Pro Val Leu Ala Ile Gly Gly Gln Val Lys Arg Ala Asp
Leu 100 105 110Leu Lys Arg Ala His Gln Ser Met Asn Asn Val Ala Met
Leu Glu Pro 115 120 125Ile Thr Lys Tyr Ala Ala Glu Val His Asp Ala
Asn Thr Leu Ser Glu 130 135 140Thr Val Ala Asn Ala Tyr Arg His Ala
Lys Ser Gly Lys Pro Gly Ala145 150 155 160Ser Phe Ile Ser Ile Pro
Gln Asp Val Thr Asp Ala Pro Val Ser Val 165 170 175Lys Ala Ile Lys
Pro Met Thr Asp Pro Lys Leu Gly Ser Ala Ser Val 180 185 190Ser Asp
Ile Asn Tyr Leu Ala Gln Ala Ile Lys Asn Ala Val Leu Pro 195 200
205Val Phe Leu Leu Gly Asn Gly Ala Ser Ser Glu Ala Val Thr Tyr Ser
210 215 220Ile Arg Gln Ile Leu Lys His Val Lys Leu Pro Val Val Glu
Thr Phe225 230 235 240Gln Gly Ala Gly Ile Val Ser Arg Asp Leu Glu
Glu Asp Thr Phe Phe 245 250 255Gly Arg Val Gly Leu Phe Arg Asn Gln
Pro Gly Asp Met Leu Leu Lys 260 265 270Lys Ser Asp Leu Val Ile Ala
Ile Gly Tyr Asp Pro Ile Glu Tyr Glu 275 280 285Ala Arg Asn Trp Asn
Ala Glu Ile Ser Ala Arg Ile Ile Val Ile Asp 290 295 300Val Glu Pro
Ala Glu Val Asp Thr Tyr Phe Gln Pro Glu Arg Glu Leu305 310 315
320Ile Gly Asn Val Glu Ala Ser Leu Asp Leu Leu Leu Pro Ala Ile Gln
325 330 335Gly Tyr Lys Leu Pro Glu Gly Ala Val Glu Tyr Leu Lys Gly
Leu Lys 340 345 350Asn Asn Val Val Glu Asp Val Lys Phe Asp Arg Gln
Pro Asp Glu Gly 355 360 365Thr Val His Pro Leu Asp Phe Ile Glu Asn
Leu Gln Glu His Thr Asp 370 375 380Asp Asp Met Thr Val Thr Phe Asp
Val Gly Ser His Tyr Ile Trp Met385 390 395 400Ala Arg Tyr Leu Lys
Ser Tyr Glu Pro Arg His Leu Leu Phe Ser Asn 405 410 415Gly Met Gln
Thr Ile Gly Ile Ala Ile Thr Trp Ala Ile Ser Ala Ala 420 425 430Leu
Val Arg Pro Lys Thr Lys Val Ile Ser Val Ser Gly Asp Gly Gly 435 440
445Phe Leu Phe Ser Ala Gln Glu Leu Glu Thr Ala Val Arg Leu Lys Leu
450 455 460Pro Ile Val His Ile Ile Trp Asn Asp Gly His Tyr Asn Met
Val Glu465 470 475 480Phe Gln Glu Glu Met Lys Tyr Gly Arg Ser Ser
Gly Val Asp Phe Gly 485 490 495Pro Val Asp Phe Val Lys Tyr Ala Glu
Ser Phe Gly Ala Lys Gly Tyr 500 505 510Arg Ala Thr Ser Lys Ala Ala
Phe Ala Ser Leu Leu Gln Glu Ala Leu 515 520 525Thr Gln Ala Val Asp
Gly Pro Val Leu Ile Asp Val Pro Ile Asp Tyr 530 535 540Lys Asp Asn
Ile Lys Leu Gly Glu Thr Ile Leu Pro Asp Glu Phe Tyr545 550 555
560151665DNAVibrio angustumCDS(1)..(1665) 15atg tcg gat aaa acc gtc
tct ggt gct gaa ctg gtt gtt gaa act tta 48Met Ser Asp Lys Thr Val
Ser Gly Ala Glu Leu Val Val Glu Thr Leu1 5 10 15aat gca cat aac gtt
cca cac att ttt ggt att cct gga gca aag gtg 96Asn Ala His Asn Val
Pro His Ile Phe Gly Ile Pro Gly Ala Lys Val 20 25 30gat gct gtt ttc
gat gct gtt tgt gat aac gga cca gaa atc att att 144Asp Ala Val Phe
Asp Ala Val Cys Asp Asn Gly Pro Glu Ile Ile Ile 35 40 45tgt cat cat
gaa caa aat gca gcg ttt atg gca gca gca act ggg cgt 192Cys His His
Glu Gln Asn Ala Ala Phe Met Ala Ala Ala Thr Gly Arg 50 55 60tta acg
ggt aaa gca ggc att tgt tta gca acc tct gga cca ggc gca 240Leu Thr
Gly Lys Ala Gly Ile Cys Leu Ala Thr Ser Gly Pro Gly Ala65 70 75
80tca aac ctt gtc aca ggc gtt gca aca gcg aat agt gaa ggt gat cct
288Ser Asn Leu Val Thr Gly Val Ala Thr Ala Asn Ser Glu Gly Asp Pro
85 90 95gtg gtt gca ctt gca ggt gct gta cct ctt tct atg tat tct cac
aat 336Val Val Ala Leu Ala Gly Ala Val Pro Leu Ser Met Tyr Ser His
Asn 100 105 110act cat caa tcc atg gat acc cgt tca ctg ttt act cct
atc acc aag 384Thr His Gln Ser Met Asp Thr Arg Ser Leu Phe Thr Pro
Ile Thr Lys 115 120 125ttt tca gca gaa gtg atg gat agc agc tcg gta
tct gat gtt gta cat 432Phe Ser Ala Glu Val Met Asp Ser Ser Ser Val
Ser Asp Val Val His 130 135 140aaa gct ttt cgt att gca gag caa cct
acc caa ggt gct agc ttt gtt 480Lys Ala Phe Arg Ile Ala Glu Gln Pro
Thr Gln Gly Ala Ser Phe Val145 150 155 160agt cta ccg caa gat att
cta act aac cgt att cct tac cag cca gta 528Ser Leu Pro Gln Asp Ile
Leu Thr Asn Arg Ile Pro Tyr Gln Pro Val 165 170 175caa cag cct aat
cca att ttg ttc ggt ggt gca cac cca caa gct att 576Gln Gln Pro Asn
Pro Ile Leu Phe Gly Gly Ala His Pro Gln Ala Ile 180 185 190cgt cag
gct gct gat cgc att aat gct gca aaa aat ccg gtg tta tta 624Arg Gln
Ala Ala Asp Arg Ile Asn Ala Ala Lys Asn Pro Val Leu Leu 195 200
205ctg ggc atg gat gca agc cag cct ttt gtt gct gat gct att cgc caa
672Leu Gly Met Asp Ala Ser Gln Pro Phe Val Ala Asp Ala Ile Arg Gln
210 215 220cta ctc aaa caa aca cca att gcc gtt gtg aat acg ttt gcc
gca gct 720Leu Leu Lys Gln Thr Pro Ile Ala Val Val Asn Thr Phe Ala
Ala Ala225 230 235 240ggg gtt att tct cat gat tta tac aac tgc ttt
tta ggt cgt gtt ggc 768Gly Val Ile Ser His Asp Leu Tyr Asn Cys Phe
Leu Gly Arg Val Gly 245 250 255tta ttt aaa aat caa ccc ggt gat att
gca tta aac agt gca gat tta 816Leu Phe Lys Asn Gln Pro Gly Asp Ile
Ala Leu Asn Ser Ala Asp Leu 260 265 270atc att acc att ggc tac agc
cca att gaa tac gat ccg att ctt tgg 864Ile Ile Thr Ile Gly Tyr Ser
Pro Ile Glu Tyr Asp Pro Ile Leu Trp 275 280 285aat aaa gat gca aac
aca cca att att cat att ggt tat caa caa gca 912Asn Lys Asp Ala Asn
Thr Pro Ile Ile His Ile Gly Tyr Gln Gln Ala 290 295 300gat tta gaa
att agc tat aac cct gtt tgt gaa gtt gtg ggt gac tta 960Asp Leu Glu
Ile Ser Tyr Asn Pro Val Cys Glu Val Val Gly Asp Leu305 310 315
320gcg gtg tct gtc acg tct att gct tct gaa tta gat aag cga gaa tca
1008Ala Val Ser Val Thr Ser Ile Ala Ser Glu Leu Asp Lys Arg Glu Ser
325 330 335tta gaa aat aac caa caa atc caa tta tta cgc cac gat tta
caa cat 1056Leu Glu Asn Asn Gln Gln Ile Gln Leu Leu Arg His Asp Leu
Gln His 340 345 350att atg cag atg ggg gta aat aaa acc tca aca aac
ggc gtt cac ccg 1104Ile Met Gln Met Gly Val Asn Lys Thr Ser Thr Asn
Gly Val His Pro 355 360 365ctt cgt ttt gtt cat gag tta cgt cgc ttt
gtt agt gac gac acc act 1152Leu Arg Phe Val His Glu Leu Arg Arg Phe
Val Ser Asp Asp Thr Thr 370 375 380gta tgt tgt gat gta ggc tct att
tat att tgg atg gca cgt tac ttc 1200Val Cys Cys Asp Val Gly Ser Ile
Tyr Ile Trp Met Ala Arg Tyr Phe385 390 395 400cac agc ttt gaa cct
cgt cgt tta ttg ttc agc aat ggc caa caa aca 1248His Ser Phe Glu Pro
Arg Arg Leu Leu Phe Ser Asn Gly Gln Gln Thr 405 410 415ttg ggc gta
gct tta cct tgg gca att gca gct tcc ctt ctt cac cct 1296Leu Gly Val
Ala Leu Pro Trp Ala Ile Ala Ala Ser Leu Leu His Pro 420 425 430aat
gaa aaa gta att tcc atg tct ggt gat ggt ggc ttc cta ttc tca 1344Asn
Glu Lys Val Ile Ser Met Ser Gly Asp Gly Gly Phe Leu Phe Ser 435 440
445tca atg gaa tta gcc acg gcc gtt cgc cat aaa tgt aat atc gtt cac
1392Ser Met Glu Leu Ala Thr Ala Val Arg His Lys Cys Asn Ile Val His
450 455 460ttt gtt tgg aca gat cac agt tat gac atg gtt aag atc caa
cag ctt 1440Phe Val Trp Thr Asp His Ser Tyr Asp Met Val Lys Ile Gln
Gln Leu465 470 475 480aaa aag tat ggt cga gag agt gcc gtc agc ttt
ata ggt cct gat att 1488Lys Lys Tyr Gly Arg Glu Ser Ala Val Ser Phe
Ile Gly Pro Asp Ile 485 490 495gtt aag tac gca gaa agc ttc ggc gca
cat ggt tta gcg atc aat act 1536Val Lys Tyr Ala Glu Ser Phe Gly Ala
His Gly Leu Ala Ile Asn Thr 500 505 510gcc gat gat att gag cct gtt
atg cga aaa gct atg agc tta agt ggc 1584Ala Asp Asp Ile Glu Pro Val
Met Arg Lys Ala Met Ser Leu Ser Gly 515 520 525cca gta ttg gtc aac
gtc aat gtt gat tat agc gat aac agt cgc cta 1632Pro Val Leu Val Asn
Val Asn Val Asp Tyr Ser Asp Asn Ser Arg Leu 530 535 540ctt gat caa
ctt cat cca tgc caa caa gat taa 1665Leu Asp Gln Leu His Pro Cys Gln
Gln Asp545 55016554PRTVibrio angustum 16Met Ser Asp Lys Thr Val Ser
Gly Ala Glu Leu Val Val Glu Thr Leu1 5 10 15Asn Ala His Asn Val Pro
His Ile Phe Gly Ile Pro Gly Ala Lys Val 20 25 30Asp Ala Val Phe Asp
Ala Val Cys Asp Asn Gly Pro Glu Ile Ile Ile 35 40 45Cys His His Glu
Gln Asn Ala Ala Phe Met Ala Ala Ala Thr Gly Arg 50 55 60Leu Thr Gly
Lys Ala Gly Ile Cys Leu Ala Thr Ser Gly Pro Gly Ala65 70 75 80Ser
Asn Leu Val Thr Gly Val Ala Thr Ala Asn Ser Glu Gly Asp Pro 85 90
95Val Val Ala Leu Ala Gly Ala Val Pro Leu Ser Met Tyr Ser His Asn
100 105 110Thr His Gln Ser Met Asp Thr Arg Ser Leu Phe Thr Pro Ile
Thr Lys 115 120 125Phe Ser Ala Glu Val Met Asp Ser Ser Ser Val Ser
Asp Val Val His 130 135 140Lys Ala Phe Arg Ile Ala Glu Gln Pro Thr
Gln Gly Ala Ser Phe Val145 150 155 160Ser Leu Pro Gln Asp Ile Leu
Thr Asn Arg Ile Pro Tyr Gln Pro Val 165 170 175Gln Gln Pro Asn Pro
Ile Leu Phe Gly Gly Ala His Pro Gln Ala Ile 180 185 190Arg Gln Ala
Ala Asp Arg Ile Asn Ala Ala Lys Asn Pro Val Leu Leu 195 200 205Leu
Gly Met Asp Ala Ser Gln Pro Phe Val Ala Asp Ala Ile Arg Gln 210 215
220Leu Leu Lys Gln Thr Pro Ile Ala Val Val Asn Thr Phe Ala Ala
Ala225 230 235 240Gly Val Ile Ser His Asp Leu Tyr Asn Cys Phe Leu
Gly Arg Val Gly 245 250 255Leu Phe Lys Asn Gln Pro Gly Asp Ile Ala
Leu Asn Ser Ala Asp Leu 260 265 270Ile Ile Thr Ile Gly Tyr Ser Pro
Ile Glu Tyr Asp Pro Ile Leu Trp 275 280 285Asn Lys Asp Ala Asn Thr
Pro Ile Ile His Ile Gly Tyr Gln Gln Ala 290 295 300Asp Leu Glu Ile
Ser Tyr Asn Pro Val Cys Glu Val Val Gly Asp Leu305 310 315 320Ala
Val Ser Val Thr Ser Ile Ala Ser Glu Leu Asp Lys Arg Glu Ser 325 330
335Leu Glu Asn Asn Gln Gln Ile Gln Leu Leu Arg His Asp Leu Gln His
340 345 350Ile Met Gln Met Gly Val Asn Lys Thr Ser Thr Asn Gly Val
His Pro 355 360 365Leu Arg Phe Val His Glu Leu Arg Arg Phe Val Ser
Asp Asp Thr Thr 370 375 380Val Cys Cys Asp Val Gly Ser Ile Tyr Ile
Trp Met Ala Arg Tyr Phe385 390 395 400His Ser Phe Glu Pro Arg Arg
Leu Leu Phe Ser Asn Gly Gln Gln Thr 405 410 415Leu Gly Val Ala Leu
Pro Trp Ala Ile Ala Ala Ser Leu Leu His Pro 420 425 430Asn Glu Lys
Val Ile Ser Met Ser Gly Asp Gly Gly Phe Leu Phe Ser 435 440 445Ser
Met Glu Leu Ala Thr Ala Val Arg His Lys Cys Asn Ile Val His 450 455
460Phe Val Trp Thr Asp His Ser Tyr Asp Met Val Lys Ile Gln Gln
Leu465 470 475 480Lys Lys Tyr Gly Arg Glu Ser Ala Val Ser Phe Ile
Gly Pro Asp Ile 485 490 495Val Lys Tyr Ala Glu Ser Phe Gly Ala His
Gly Leu Ala Ile Asn Thr 500 505 510Ala Asp Asp Ile Glu Pro Val Met
Arg Lys Ala Met Ser Leu Ser Gly 515 520 525Pro Val Leu Val Asn Val
Asn Val Asp Tyr Ser Asp Asn Ser Arg Leu 530 535 540Leu Asp Gln Leu
His Pro Cys Gln Gln Asp545 550171689DNABacillus cereus 17ttgagtacag
gtgtaaaagc aaacgacgtg aagacaaaaa caaaaggagc agatcttgtt 60gttgattgtt
taattaaaca aggtgttaca catgttttcg gtattccagg agcaaagatt
120gactctgtat ttgatgtact
gcaagaaaga ggaccagagt taattgtttg tcgtcatgaa 180caaaatgcag
catttatggc agctgctatt ggtagattaa caggaaaacc gggcgtatgt
240cttgtaactt caggaccagg gacatcaaat ttagcgacag gtcttgttac
tgcgaatgcg 300gagagtgatc ccgttgttgc tttagctggt gcagttccgc
gtacggatcg attaaaacgt 360acacatcaat ctatggataa tgctgcacta
ttcgaaccaa tcacaaaata tagcgtagaa 420gtagagcatc ctgataatgt
gccagaagca ttatcaaatg cattccgaag tgcgacttct 480acaaatccag
gagcaacttt agtaagtttg ccgcaagacg ttatgactgc ggaaacgact
540gtagagtcta tcggtgcgct ttctaagcca cagcttggaa tcgctcccac
acatgatatt 600acatatgtag tagataaaat aaaagcagcg aaattaccag
ttattttact cggtatgaga 660gcgagcacaa atgaagtgac gaaagccgtt
cgtaaattaa ttgcggatac agaacttcct 720gtcgttgaaa catatcaagc
ggctggtgcc atttcacgtg agttagaaga tcatttcttc 780ggccgtgttg
gactattccg taaccaacca ggtgatattt tactagaaga ggcagatctt
840gttatttcta tcggttatga tccaattgag tatgatccaa agttctggaa
taaacttgga 900gacagaacga ttattcatct tgatgaccat caagcagata
tagatcatga ttaccaacca 960gagcgtgaat taattggtga tattgcctta
acagtaaata gcatcgcaga aaagttaccg 1020aaacttgtgt taagtacgaa
atcagaagca gtgttagaac gattacgcgc gaaattatca 1080gaacaagcag
aagttccaaa tcgtccttca gaaggtgtta cacatccgct tcaagtgatt
1140cgtacacttc gttctttaat tagtgacgac acaaccgtta catgtgacat
cggttcccat 1200tctatttgga tggcgagatg tttccgttct tatgaaccac
gtagattatt atttagtaac 1260ggtatgcaga cgttaggtgt tgcacttcct
tgggcaattg ctgctacttt agtagaacca 1320ggtaaaaaag tagtttccgt
atcaggtgac ggtggtttct tattctcagc gatggagtta 1380gaaacggcgg
tacgtttaaa ttctccaatc gtccatcttg tttggagaga cggcacatat
1440gatatggttg cattccaaca aatgatgaaa tacggcagaa catcagctac
agagtttggt 1500gatgttgatc ttgttaaata tgcggaaagt ttcggggcgt
taggtcttcg tgttaacacg 1560cctgatgaat tagaaggggt attgaaagaa
gcactagcag cagacggccc tgtcattatt 1620gatattccaa ttgactatcg
tgacaacatt aaattaagcg aaaaattatt accaaaccaa 1680ttaaactaa
168918562PRTBacillus cereus 18Met Ser Thr Gly Val Lys Ala Asn Asp
Val Lys Thr Lys Thr Lys Gly1 5 10 15Ala Asp Leu Val Val Asp Cys Leu
Ile Lys Gln Gly Val Thr His Val 20 25 30Phe Gly Ile Pro Gly Ala Lys
Ile Asp Ser Val Phe Asp Val Leu Gln 35 40 45Glu Arg Gly Pro Glu Leu
Ile Val Cys Arg His Glu Gln Asn Ala Ala 50 55 60Phe Met Ala Ala Ala
Ile Gly Arg Leu Thr Gly Lys Pro Gly Val Cys65 70 75 80Leu Val Thr
Ser Gly Pro Gly Thr Ser Asn Leu Ala Thr Gly Leu Val 85 90 95Thr Ala
Asn Ala Glu Ser Asp Pro Val Val Ala Leu Ala Gly Ala Val 100 105
110Pro Arg Thr Asp Arg Leu Lys Arg Thr His Gln Ser Met Asp Asn Ala
115 120 125Ala Leu Phe Glu Pro Ile Thr Lys Tyr Ser Val Glu Val Glu
His Pro 130 135 140Asp Asn Val Pro Glu Ala Leu Ser Asn Ala Phe Arg
Ser Ala Thr Ser145 150 155 160Thr Asn Pro Gly Ala Thr Leu Val Ser
Leu Pro Gln Asp Val Met Thr 165 170 175Ala Glu Thr Thr Val Glu Ser
Ile Gly Ala Leu Ser Lys Pro Gln Leu 180 185 190Gly Ile Ala Pro Thr
His Asp Ile Thr Tyr Val Val Asp Lys Ile Lys 195 200 205Ala Ala Lys
Leu Pro Val Ile Leu Leu Gly Met Arg Ala Ser Thr Asn 210 215 220Glu
Val Thr Lys Ala Val Arg Lys Leu Ile Ala Asp Thr Glu Leu Pro225 230
235 240Val Val Glu Thr Tyr Gln Ala Ala Gly Ala Ile Ser Arg Glu Leu
Glu 245 250 255Asp His Phe Phe Gly Arg Val Gly Leu Phe Arg Asn Gln
Pro Gly Asp 260 265 270Ile Leu Leu Glu Glu Ala Asp Leu Val Ile Ser
Ile Gly Tyr Asp Pro 275 280 285Ile Glu Tyr Asp Pro Lys Phe Trp Asn
Lys Leu Gly Asp Arg Thr Ile 290 295 300Ile His Leu Asp Asp His Gln
Ala Asp Ile Asp His Asp Tyr Gln Pro305 310 315 320Glu Arg Glu Leu
Ile Gly Asp Ile Ala Leu Thr Val Asn Ser Ile Ala 325 330 335Glu Lys
Leu Pro Lys Leu Val Leu Ser Thr Lys Ser Glu Ala Val Leu 340 345
350Glu Arg Leu Arg Ala Lys Leu Ser Glu Gln Ala Glu Val Pro Asn Arg
355 360 365Pro Ser Glu Gly Val Thr His Pro Leu Gln Val Ile Arg Thr
Leu Arg 370 375 380Ser Leu Ile Ser Asp Asp Thr Thr Val Thr Cys Asp
Ile Gly Ser His385 390 395 400Ser Ile Trp Met Ala Arg Cys Phe Arg
Ser Tyr Glu Pro Arg Arg Leu 405 410 415Leu Phe Ser Asn Gly Met Gln
Thr Leu Gly Val Ala Leu Pro Trp Ala 420 425 430Ile Ala Ala Thr Leu
Val Glu Pro Gly Lys Lys Val Val Ser Val Ser 435 440 445Gly Asp Gly
Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala Val 450 455 460Arg
Leu Asn Ser Pro Ile Val His Leu Val Trp Arg Asp Gly Thr Tyr465 470
475 480Asp Met Val Ala Phe Gln Gln Met Met Lys Tyr Gly Arg Thr Ser
Ala 485 490 495Thr Glu Phe Gly Asp Val Asp Leu Val Lys Tyr Ala Glu
Ser Phe Gly 500 505 510Ala Leu Gly Leu Arg Val Asn Thr Pro Asp Glu
Leu Glu Gly Val Leu 515 520 525Lys Glu Ala Leu Ala Ala Asp Gly Pro
Val Ile Ile Asp Ile Pro Ile 530 535 540Asp Tyr Arg Asp Asn Ile Lys
Leu Ser Glu Lys Leu Leu Pro Asn Gln545 550 555 560Leu
Asn19780DNAKlebsiella pneumoniae 19atgaatcatt ctgctgaatg cacctgcgaa
gagagtctat gcgaaaccct gcgggcgttt 60tccgcgcagc atcccgagag cgtgctctat
cagacatcgc tcatgagcgc cctgctgagc 120ggggtttacg aaggcagcac
caccatcgcg gacctgctga aacacggcga tttcggcctc 180ggcaccttta
atgagctgga cggggagctg atcgccttca gcagtcaggt ctatcagctg
240cgcgccgacg gcagcgcgcg caaagcccag ccggagcaga aaacgccgtt
cgcggtgatg 300acctggttcc agccgcagta ccggaaaacc tttgaccatc
cggtgagccg ccagcagctg 360cacgaggtga tcgaccagca aatcccctct
gacaacctgt tctgcgccct gcgcatcgac 420ggccatttcc gccatgccca
tacccgcacc gtgccgcgcc agacgccgcc gtaccgggcg 480atgaccgacg
tcctcgacga tcagccggtg ttccgcttta accagcgcga aggggtgctg
540gtcggcttcc ggaccccgca gcatatgcag gggatcaacg tcgccgggta
tcacgagcac 600tttattaccg atgaccgcaa aggcggcggt cacctgctgg
attaccagct cgaccatggg 660gtgctgacct tcggcgaaat tcacaagctg
atgatcgacc tgcccgccga cagcgcgttc 720ctgcaggcta atctgcatcc
cgataatctc gatgccgcca tccgttccgt agaaagttaa 78020259PRTKlebsiella
pneumoniae 20Met Asn His Ser Ala Glu Cys Thr Cys Glu Glu Ser Leu
Cys Glu Thr1 5 10 15Leu Arg Ala Phe Ser Ala Gln His Pro Glu Ser Val
Leu Tyr Gln Thr 20 25 30Ser Leu Met Ser Ala Leu Leu Ser Gly Val Tyr
Glu Gly Ser Thr Thr 35 40 45Ile Ala Asp Leu Leu Lys His Gly Asp Phe
Gly Leu Gly Thr Phe Asn 50 55 60Glu Leu Asp Gly Glu Leu Ile Ala Phe
Ser Ser Gln Val Tyr Gln Leu65 70 75 80Arg Ala Asp Gly Ser Ala Arg
Lys Ala Gln Pro Glu Gln Lys Thr Pro 85 90 95Phe Ala Val Met Thr Trp
Phe Gln Pro Gln Tyr Arg Lys Thr Phe Asp 100 105 110His Pro Val Ser
Arg Gln Gln Leu His Glu Val Ile Asp Gln Gln Ile 115 120 125Pro Ser
Asp Asn Leu Phe Cys Ala Leu Arg Ile Asp Gly His Phe Arg 130 135
140His Ala His Thr Arg Thr Val Pro Arg Gln Thr Pro Pro Tyr Arg
Ala145 150 155 160Met Thr Asp Val Leu Asp Asp Gln Pro Val Phe Arg
Phe Asn Gln Arg 165 170 175Glu Gly Val Leu Val Gly Phe Arg Thr Pro
Gln His Met Gln Gly Ile 180 185 190Asn Val Ala Gly Tyr His Glu His
Phe Ile Thr Asp Asp Arg Lys Gly 195 200 205Gly Gly His Leu Leu Asp
Tyr Gln Leu Asp His Gly Val Leu Thr Phe 210 215 220Gly Glu Ile His
Lys Leu Met Ile Asp Leu Pro Ala Asp Ser Ala Phe225 230 235 240Leu
Gln Ala Asn Leu His Pro Asp Asn Leu Asp Ala Ala Ile Arg Ser 245 250
255Val Glu Ser21768DNABacillus subtilis 21atgaaacgag aaagcaacat
tcaagtgctc agccgtggtc aaaaagatca gcctgtgagc 60cagatttatc aagtatcaac
aatgacttct ctattagacg gagtatatga cggagatttt 120gaactgtcag
agattccgaa atatggagac ttcggtatcg gaacctttaa caagcttgac
180ggagagctga ttgggtttga cggcgaattt taccgtcttc gctcagacgg
aaccgcgaca 240ccggtccaaa atggagaccg ttcaccgttc tgttcattta
cgttctttac accggacatg 300acgcacaaaa ttgatgcgaa aatgacacgc
gaagactttg aaaaagagat caacagcatg 360ctgccaagca gaaacttatt
ttatgcaatt cgcattgacg gattgtttaa aaaggtgcag 420acaagaacag
tagaacttca agaaaaacct tacgtgccaa tggttgaagc ggtcaaaaca
480cagccgattt tcaacttcga caacgtgaga ggaacgattg taggtttctt
gacaccagct 540tatgcaaacg gaatcgccgt ttctggctat cacctgcact
tcattgacga aggacgcaat 600tcaggcggac acgtttttga ctatgtgctt
gaggattgca cggttacgat ttctcaaaaa 660atgaacatga atctcagact
tccgaacaca gcggatttct ttaatgcgaa tctggataac 720cctgattttg
cgaaagatat cgaaacaact gaaggaagcc ctgaataa 76822255PRTBacillus
subtilis 22Met Lys Arg Glu Ser Asn Ile Gln Val Leu Ser Arg Gly Gln
Lys Asp1 5 10 15Gln Pro Val Ser Gln Ile Tyr Gln Val Ser Thr Met Thr
Ser Leu Leu 20 25 30Asp Gly Val Tyr Asp Gly Asp Phe Glu Leu Ser Glu
Ile Pro Lys Tyr 35 40 45Gly Asp Phe Gly Ile Gly Thr Phe Asn Lys Leu
Asp Gly Glu Leu Ile 50 55 60Gly Phe Asp Gly Glu Phe Tyr Arg Leu Arg
Ser Asp Gly Thr Ala Thr65 70 75 80Pro Val Gln Asn Gly Asp Arg Ser
Pro Phe Cys Ser Phe Thr Phe Phe 85 90 95Thr Pro Asp Met Thr His Lys
Ile Asp Ala Lys Met Thr Arg Glu Asp 100 105 110Phe Glu Lys Glu Ile
Asn Ser Met Leu Pro Ser Arg Asn Leu Phe Tyr 115 120 125Ala Ile Arg
Ile Asp Gly Leu Phe Lys Lys Val Gln Thr Arg Thr Val 130 135 140Glu
Leu Gln Glu Lys Pro Tyr Val Pro Met Val Glu Ala Val Lys Thr145 150
155 160Gln Pro Ile Phe Asn Phe Asp Asn Val Arg Gly Thr Ile Val Gly
Phe 165 170 175Leu Thr Pro Ala Tyr Ala Asn Gly Ile Ala Val Ser Gly
Tyr His Leu 180 185 190His Phe Ile Asp Glu Gly Arg Asn Ser Gly Gly
His Val Phe Asp Tyr 195 200 205Val Leu Glu Asp Cys Thr Val Thr Ile
Ser Gln Lys Met Asn Met Asn 210 215 220Leu Arg Leu Pro Asn Thr Ala
Asp Phe Phe Asn Ala Asn Leu Asp Asn225 230 235 240Pro Asp Phe Ala
Lys Asp Ile Glu Thr Thr Glu Gly Ser Pro Glu 245 250
25523780DNAKlebsiella terrigena 23gtgaatcatt atcctgaatg cacctgccag
gagagcctgt gcgaaaccgt acgcggcttc 60tccgcccacc accctgatag cgttatctat
cagacctctc tgatgagcgc gctgctgagc 120ggggtctatg agggtagcac
caccatcgcc gacctgctga cccacggcga cttcggtctc 180ggcaccttta
acgaactcga tggcgaactg attgccttta gcagcgaggt ctaccagctg
240cgcgctgacg gcagcgcgcg taaagcccgg gcggatcaaa aaacgccctt
cgcggtgatg 300acctggttca gaccgcagta ccgtaaaacc tttgaccacc
cggtcagccg ccagcagctg 360cacgacgtta tcgaccagca aatcccctcc
gataacctgt tctgcgccct gcatattgat 420ggtcactttc gccacgccca
cacccgcacc gtgccgcggc agacgccgcc ctatcgggcg 480atgaccgacg
tgctcgatga ccagccggtt ttccgcttca accagcgcaa ggggacgctg
540gtcggctttc gcaccccgca gcatatgcag ggccttaacg ttgccggcta
ccacgagcac 600tttattaccg acgatcgcca gggcggcggc catctgctgg
actaccagct cgatagcggc 660gtgctgacct tcggcgagat ccacaagctg
atgattgacc tcccggccga cagcgctttc 720ctgcaggccg acctgcatcc
tgacaatctc gatgccgcta ttcgtgcggt agaaaactaa 78024259PRTKlebsiella
terrigena 24Met Asn His Tyr Pro Glu Cys Thr Cys Gln Glu Ser Leu Cys
Glu Thr1 5 10 15Val Arg Gly Phe Ser Ala His His Pro Asp Ser Val Ile
Tyr Gln Thr 20 25 30Ser Leu Met Ser Ala Leu Leu Ser Gly Val Tyr Glu
Gly Ser Thr Thr 35 40 45Ile Ala Asp Leu Leu Thr His Gly Asp Phe Gly
Leu Gly Thr Phe Asn 50 55 60Glu Leu Asp Gly Glu Leu Ile Ala Phe Ser
Ser Glu Val Tyr Gln Leu65 70 75 80Arg Ala Asp Gly Ser Ala Arg Lys
Ala Arg Ala Asp Gln Lys Thr Pro 85 90 95Phe Ala Val Met Thr Trp Phe
Arg Pro Gln Tyr Arg Lys Thr Phe Asp 100 105 110His Pro Val Ser Arg
Gln Gln Leu His Asp Val Ile Asp Gln Gln Ile 115 120 125Pro Ser Asp
Asn Leu Phe Cys Ala Leu His Ile Asp Gly His Phe Arg 130 135 140His
Ala His Thr Arg Thr Val Pro Arg Gln Thr Pro Pro Tyr Arg Ala145 150
155 160Met Thr Asp Val Leu Asp Asp Gln Pro Val Phe Arg Phe Asn Gln
Arg 165 170 175Lys Gly Thr Leu Val Gly Phe Arg Thr Pro Gln His Met
Gln Gly Leu 180 185 190Asn Val Ala Gly Tyr His Glu His Phe Ile Thr
Asp Asp Arg Gln Gly 195 200 205Gly Gly His Leu Leu Asp Tyr Gln Leu
Asp Ser Gly Val Leu Thr Phe 210 215 220Gly Glu Ile His Lys Leu Met
Ile Asp Leu Pro Ala Asp Ser Ala Phe225 230 235 240Leu Gln Ala Asp
Leu His Pro Asp Asn Leu Asp Ala Ala Ile Arg Ala 245 250 255Val Glu
Asn25771DNAKlebsiella pneumoniae 25atgaaaaaag tcgcacttgt taccggcgcc
ggccagggga ttggtaaagc tatcgccctt 60cgtctggtga aggatggatt tgccgtggcc
attgccgatt ataacgacgc caccgccaaa 120gcggtcgcct cggaaatcaa
ccaggccggc ggacacgccg tggcggtgaa agtggatgtc 180tccgaccgcg
atcaggtatt tgccgccgtt gaacaggcgc gcaaaacgct gggcggcttc
240gacgtcatcg tcaataacgc cggtgtggca ccgtctacgc cgatcgagtc
cattaccccg 300gagattgtcg acaaagtcta caacatcaac gtcaaagggg
tgatctgggg tattcaggcg 360gcggtcgagg cctttaagaa agaggggcac
ggcgggaaaa tcatcaacgc ctgttcccag 420gccggccacg tcggcaaccc
ggagctggcg gtgtatagct ccagtaaatt cgcggtacgc 480ggcttaaccc
agaccgccgc tcgcgacctc gcgccgctgg gcatcacggt caacggctac
540tgcccgggga ttgtcaaaac gccaatgtgg gccgaaattg accgccaggt
gtccgaagcc 600gccggtaaac cgctgggcta cggtaccgcc gagttcgcca
aacgcatcac tctcggtcgt 660ctgtccgagc cggaagatgt cgccgcctgc
gtctcctatc ttgccagccc ggattctgat 720tacatgaccg gtcagtcgtt
gctgatcgac ggcgggatgg tatttaacta a 77126256PRTKlebsiella pneumoniae
26Met Lys Lys Val Ala Leu Val Thr Gly Ala Gly Gln Gly Ile Gly Lys1
5 10 15Ala Ile Ala Leu Arg Leu Val Lys Asp Gly Phe Ala Val Ala Ile
Ala 20 25 30Asp Tyr Asn Asp Ala Thr Ala Lys Ala Val Ala Ser Glu Ile
Asn Gln 35 40 45Ala Gly Gly His Ala Val Ala Val Lys Val Asp Val Ser
Asp Arg Asp 50 55 60Gln Val Phe Ala Ala Val Glu Gln Ala Arg Lys Thr
Leu Gly Gly Phe65 70 75 80Asp Val Ile Val Asn Asn Ala Gly Val Ala
Pro Ser Thr Pro Ile Glu 85 90 95Ser Ile Thr Pro Glu Ile Val Asp Lys
Val Tyr Asn Ile Asn Val Lys 100 105 110Gly Val Ile Trp Gly Ile Gln
Ala Ala Val Glu Ala Phe Lys Lys Glu 115 120 125Gly His Gly Gly Lys
Ile Ile Asn Ala Cys Ser Gln Ala Gly His Val 130 135 140Gly Asn Pro
Glu Leu Ala Val Tyr Ser Ser Ser Lys Phe Ala Val Arg145 150 155
160Gly Leu Thr Gln Thr Ala Ala Arg Asp Leu Ala Pro Leu Gly Ile Thr
165 170 175Val Asn Gly Tyr Cys Pro Gly Ile Val Lys Thr Pro Met Trp
Ala Glu 180 185 190Ile Asp Arg Gln Val Ser Glu Ala Ala Gly Lys Pro
Leu Gly Tyr Gly 195 200 205Thr Ala Glu Phe Ala Lys Arg Ile Thr Leu
Gly Arg Leu Ser Glu Pro 210 215 220Glu Asp Val Ala Ala Cys Val Ser
Tyr Leu Ala Ser Pro Asp Ser Asp225 230 235 240Tyr Met Thr Gly Gln
Ser Leu Leu Ile Asp Gly Gly Met Val Phe Asn 245 250
255271053DNABacillus cereus 27atgaaagcac tactttggca taatcaacgt
gatgtacgag tagaagaagt accagaacca 60acagtaaaac caggaacagt gaaaatcaaa
gttaaatggt gtggtatttg tgggacagac 120ttgcatgaat atttagcagg
gcctattttt attccaacag aagaacatcc attaacacat 180gtgaaagcac
ctgttatttt aggtcatgag tttagtggtg aggtaataga gattggtgaa
240ggagttacat ctcataaagt gggagaccgc gttgttgtag agccaattta
ttcttgtggt 300aaatgtgaag cttgtaaaca tggacattac aatgtttgtg
aacaacttgt tttccacggt 360cttggcggag aaggcggcgg tttctctgaa
tatacagtag
taccagaaga tatggttcat 420cacattccag atgaaatgac gtatgaacaa
ggtgcgcttg tagaaccagc agcagtagca 480gttcatgcag tacgtcaaag
taaattaaaa gaaggggaag ctgtagcggt atttggttgc 540ggtccaattg
gacttcttgt tatccaagca gctaaagcag caggagcaac tcctgttatt
600gcagttgaac tttctaaaga acgtcaagag ttagcgaaat tagcaggtgc
ggattatgta 660ttaaatccag caactcaaga tgtgttagct gaaattcgta
acttaacaaa tggtttaggt 720gtaaatgtta gctttgaagt aacaggtgtt
gaagttgtac tacgccaagc gattgaaagt 780acaagcttcg aaggacaaac
tgtaattgtt agtgtatggg aaaaagacgc aacaattact 840ccaaataact
tagtattaaa agaaaaagaa gttattggta ttttaggata ccgtcacatc
900ttcccagctg ttattaaatt gattagctcc ggtcaaattc aagcagagaa
attaattacg 960aaaaaaatta cagtggatca agttgttgaa gaaggatttg
aagcacttgt aaaagataaa 1020acacaagtga aaattcttgt ttcacctaaa taa
105328350PRTBacillus cereus 28Met Lys Ala Leu Leu Trp His Asn Gln
Arg Asp Val Arg Val Glu Glu1 5 10 15Val Pro Glu Pro Thr Val Lys Pro
Gly Thr Val Lys Ile Lys Val Lys 20 25 30Trp Cys Gly Ile Cys Gly Thr
Asp Leu His Glu Tyr Leu Ala Gly Pro 35 40 45Ile Phe Ile Pro Thr Glu
Glu His Pro Leu Thr His Val Lys Ala Pro 50 55 60Val Ile Leu Gly His
Glu Phe Ser Gly Glu Val Ile Glu Ile Gly Glu65 70 75 80Gly Val Thr
Ser His Lys Val Gly Asp Arg Val Val Val Glu Pro Ile 85 90 95Tyr Ser
Cys Gly Lys Cys Glu Ala Cys Lys His Gly His Tyr Asn Val 100 105
110Cys Glu Gln Leu Val Phe His Gly Leu Gly Gly Glu Gly Gly Gly Phe
115 120 125Ser Glu Tyr Thr Val Val Pro Glu Asp Met Val His His Ile
Pro Asp 130 135 140Glu Met Thr Tyr Glu Gln Gly Ala Leu Val Glu Pro
Ala Ala Val Ala145 150 155 160Val His Ala Val Arg Gln Ser Lys Leu
Lys Glu Gly Glu Ala Val Ala 165 170 175Val Phe Gly Cys Gly Pro Ile
Gly Leu Leu Val Ile Gln Ala Ala Lys 180 185 190Ala Ala Gly Ala Thr
Pro Val Ile Ala Val Glu Leu Ser Lys Glu Arg 195 200 205Gln Glu Leu
Ala Lys Leu Ala Gly Ala Asp Tyr Val Leu Asn Pro Ala 210 215 220Thr
Gln Asp Val Leu Ala Glu Ile Arg Asn Leu Thr Asn Gly Leu Gly225 230
235 240Val Asn Val Ser Phe Glu Val Thr Gly Val Glu Val Val Leu Arg
Gln 245 250 255Ala Ile Glu Ser Thr Ser Phe Glu Gly Gln Thr Val Ile
Val Ser Val 260 265 270Trp Glu Lys Asp Ala Thr Ile Thr Pro Asn Asn
Leu Val Leu Lys Glu 275 280 285Lys Glu Val Ile Gly Ile Leu Gly Tyr
Arg His Ile Phe Pro Ala Val 290 295 300Ile Lys Leu Ile Ser Ser Gly
Gln Ile Gln Ala Glu Lys Leu Ile Thr305 310 315 320Lys Lys Ile Thr
Val Asp Gln Val Val Glu Glu Gly Phe Glu Ala Leu 325 330 335Val Lys
Asp Lys Thr Gln Val Lys Ile Leu Val Ser Pro Lys 340 345
350291113DNALactococcus lactis 29ttgcctgaaa cgacaaccat cctatataga
ggaggcgttt ttatgcgcgc agcacgtttt 60tacgaccgcg gggatatccg cattgatgaa
attaatgaac caatagtaaa agctggccaa 120gttggcattg atgtggcttg
gtgtggaatt tgtggaacag atctccatga atttttagat 180ggcccaattt
tttgtccgtc agcagaacat cctaatccaa ttactggaga agtaccacca
240gtcactcttg gacatgaaat gtctggggtt gtaaatttta taggtgaagg
agtaagcgga 300cttaaagtag gtgaccatgt cgttgtcgaa ccttatatcg
ttcccgaagg gactgataca 360agtgaaactg gacattataa cctctcagaa
ggctcaaact ttattggttt gggcggaaat 420ggtggaggtt tggctgaaaa
aatttctgtt gatgaacgtt gggttcacaa aattcctgat 480aacttaccat
tggatgaagc tgctctaatt gagccactat cagtcggcta tcacgctgtt
540gaacgagcaa atttaagtga aaagagtacg gtattagttg ttggtgctgg
accaattgga 600ctattaactg ctgccgttgc aaaagcgcaa ggacatactg
ttatcatcag tgaacctagt 660ggacttcgtc gtaaaaaagc acaagaagca
caagttgctg attatttctt caatccaatt 720gaagatgaca ttcaagctaa
agttcatgaa attaatgaaa aaggagtgga cgcagccttt 780gaatgtacct
ctgtccaacc gggatttgac gcttgtctag atgcgattcg tatgggtgga
840acagttgtca ttgtcgcaat ttggggcaag cctgctagtg ttgatatggc
aaaattagta 900atcaaagaag ctaacctttt aggaacgatt gcttataata
acactcatcc aaaaacaatt 960gatttagtat caacaggtaa aataaaattg
gaccaattca tcacagctaa aatcggtttg 1020gatgatttga ttgataaagg
attcgatacg ctgattcatc ataatgaaac agctgttaaa 1080attttagttt
caccaactgg taaaggtcta taa 111330370PRTLactococcus lactis 30Met Pro
Glu Thr Thr Thr Ile Leu Tyr Arg Gly Gly Val Phe Met Arg1 5 10 15Ala
Ala Arg Phe Tyr Asp Arg Gly Asp Ile Arg Ile Asp Glu Ile Asn 20 25
30Glu Pro Ile Val Lys Ala Gly Gln Val Gly Ile Asp Val Ala Trp Cys
35 40 45Gly Ile Cys Gly Thr Asp Leu His Glu Phe Leu Asp Gly Pro Ile
Phe 50 55 60Cys Pro Ser Ala Glu His Pro Asn Pro Ile Thr Gly Glu Val
Pro Pro65 70 75 80Val Thr Leu Gly His Glu Met Ser Gly Val Val Asn
Phe Ile Gly Glu 85 90 95Gly Val Ser Gly Leu Lys Val Gly Asp His Val
Val Val Glu Pro Tyr 100 105 110Ile Val Pro Glu Gly Thr Asp Thr Ser
Glu Thr Gly His Tyr Asn Leu 115 120 125Ser Glu Gly Ser Asn Phe Ile
Gly Leu Gly Gly Asn Gly Gly Gly Leu 130 135 140Ala Glu Lys Ile Ser
Val Asp Glu Arg Trp Val His Lys Ile Pro Asp145 150 155 160Asn Leu
Pro Leu Asp Glu Ala Ala Leu Ile Glu Pro Leu Ser Val Gly 165 170
175Tyr His Ala Val Glu Arg Ala Asn Leu Ser Glu Lys Ser Thr Val Leu
180 185 190Val Val Gly Ala Gly Pro Ile Gly Leu Leu Thr Ala Ala Val
Ala Lys 195 200 205Ala Gln Gly His Thr Val Ile Ile Ser Glu Pro Ser
Gly Leu Arg Arg 210 215 220Lys Lys Ala Gln Glu Ala Gln Val Ala Asp
Tyr Phe Phe Asn Pro Ile225 230 235 240Glu Asp Asp Ile Gln Ala Lys
Val His Glu Ile Asn Glu Lys Gly Val 245 250 255Asp Ala Ala Phe Glu
Cys Thr Ser Val Gln Pro Gly Phe Asp Ala Cys 260 265 270Leu Asp Ala
Ile Arg Met Gly Gly Thr Val Val Ile Val Ala Ile Trp 275 280 285Gly
Lys Pro Ala Ser Val Asp Met Ala Lys Leu Val Ile Lys Glu Ala 290 295
300Asn Leu Leu Gly Thr Ile Ala Tyr Asn Asn Thr His Pro Lys Thr
Ile305 310 315 320Asp Leu Val Ser Thr Gly Lys Ile Lys Leu Asp Gln
Phe Ile Thr Ala 325 330 335Lys Ile Gly Leu Asp Asp Leu Ile Asp Lys
Gly Phe Asp Thr Leu Ile 340 345 350His His Asn Glu Thr Ala Val Lys
Ile Leu Val Ser Pro Thr Gly Lys 355 360 365Gly Leu
370312532DNARoseburia inulinivorans 31atgggcaatt acgattcaac
accgatagct aaaagtgata ggattaaaag attggttgat 60catttgtatg ctaaaatgcc
tgaaattgag gccgctagag cagagctaat tactgaatcc 120tttaaggcca
ccgaaggtca acctgttgtt atgagaaagg ctagagcttt tgaacatata
180ctaaagaatt tgccaattat cataagacca gaagaactga ttgttggctc
aactacaatt 240gcccctagag gttgccaaac gtatccagaa ttctcatacg
agtggttaga ggctgaattt 300gaaactgtcg aaacgcgttc agctgaccca
ttttatattt cagaagaaac gaagaaacgt 360ttgctggctg ccgatgctta
ttggaaaggt aaaacaacct cagagttggc aacttcatat 420atggccccag
aaactctaag agccatgaag cataacttct tcacccctgg aaactacttc
480tacaatggtg tcggtcatgt cacagttcaa tatgaaacag tattagcaat
cggcttgaat 540ggagtaaaag agaaggttag gaaagagatg gagaattgtc
attttggtga tgccgattat 600agtacaaaga tgtgtttctt ggagagcatt
ttaatatcgt gtgatgccgt aatcacttat 660gctaatagat atgccaagat
ggccgaggaa atggctgaaa aagaaacaga tgctgcaagg 720aggcaagaac
tattaacaat cgccagggtt tgcaaaaacg ttcctgaatt cccagccgaa
780agcttccagg aggcctgcca atccttttgg ttcatacaac aagtgcttca
aattgaatcc 840agtggtcatt caatttcccc aggtagattt gatcaatata
tgtatcctta ttacgaaaag 900gatttaaagg aaggtagctt aactagggaa
tatgctcagg aactgatcga ttgtatctgg 960gttaagttaa atgatctgaa
taagtgcagg gatgctgcct ctgctgaggg ctttgcagga 1020tattccttat
ttcaaaactt aatcgttggg ggccaaacgg ttcaaggaag ggacgccacc
1080aatgatttga gttttatgtg tatcacggca tctgaacacg tctttttacc
gatgccgtcg 1140ttgtctataa gagtttggca tggtagttcc aaagcactgc
ttatgagagc agctgaattg 1200actagaaccg gtataggctt acctgcttat
tacaatgatg aagtcatcat accagctttg 1260gtgcataggg gtgctactat
ggatgaagca agaaattaca acataatagg atgtgtcgaa 1320ccgcaggttc
ctggtaaaac tgatggctgg cacgatgcag cattctttaa catgtgcaga
1380cctttggaaa tggtgtttag taatggttat gataacggtg aaattgcatc
tatacaaact 1440ggtaacgtag aatcttttca gagttttgat gagtttatgg
aagcttacag aaaacaaatg 1500ctatataaca tagaacttat ggtaaatgcc
gacaacgcga tagattatgc ccacgcaaag 1560ttggccccat tgccatttga
gtcatgtttg gttgatgact gtataaagag aggaatgtcc 1620gctcaggaag
gcggcgcaat ctataatttc actggtccac agggctttgg tattgcaaac
1680gttgctgata gcttgtatac gattaagaaa ttggtgttcg aggagaagag
aattacgatg 1740ggtgaattaa agaaagcgtt ggaaatgaat tatggtaagg
gtttggatgc cacaaccgct 1800ggtgacatcg caatgcaggt cgcgaaggga
ctaaaagatg ccggacagga agtgggtccc 1860gacgtgatcg ctaatacaat
ccgtcaagtt cttgaaatgg aattaccaga agatgtaaga 1920aagagatatg
aagagatcca tgaaatgata cttgagttac caaagtatgg taatgatata
1980gatgaagttg atgaattagc tagagaagca gcttactttt acacaagacc
attagaaact 2040tttaagaatc caaggggtgg catgtatcaa gccggccttt
atcccgtgtc cgctaatgtg 2100ccactaggcg ctcaaacggg ggccacaccc
gatggacgtt tggcgcatac acccgtggcg 2160gatggcgttg gtccgacatc
aggcttcgat atatccggac caacagcttc ttgcaattct 2220gtcgccaagt
tggatcatgc tatagcctct aatggtacct tatttaatat gaagatgcac
2280ccaaccgcaa tggcaggtga aaagggctta gaatccttca tatcgttgat
ccgtggttat 2340ttcgatcaac aaggtatgca catgcaattt aacgtagtag
acagggctac actgcttgat 2400gcgcaggccc accctgaaaa gtattcaggc
ttaattgtca gagtggcagg ttattctgcc 2460ctttttacca cattgtccaa
gtcattacaa gatgatataa tcaaacgtac cgaacaagca 2520gacaatagat ag
253232843PRTRoseburia inulinivorans 32Met Gly Asn Tyr Asp Ser Thr
Pro Ile Ala Lys Ser Asp Arg Ile Lys1 5 10 15Arg Leu Val Asp His Leu
Tyr Ala Lys Met Pro Glu Ile Glu Ala Ala 20 25 30Arg Ala Glu Leu Ile
Thr Glu Ser Phe Lys Ala Thr Glu Gly Gln Pro 35 40 45Val Val Met Arg
Lys Ala Arg Ala Phe Glu His Ile Leu Lys Asn Leu 50 55 60Pro Ile Ile
Ile Arg Pro Glu Glu Leu Ile Val Gly Ser Thr Thr Ile65 70 75 80Ala
Pro Arg Gly Cys Gln Thr Tyr Pro Glu Phe Ser Tyr Glu Trp Leu 85 90
95Glu Ala Glu Phe Glu Thr Val Glu Thr Arg Ser Ala Asp Pro Phe Tyr
100 105 110Ile Ser Glu Glu Thr Lys Lys Arg Leu Leu Ala Ala Asp Ala
Tyr Trp 115 120 125Lys Gly Lys Thr Thr Ser Glu Leu Ala Thr Ser Tyr
Met Ala Pro Glu 130 135 140Thr Leu Arg Ala Met Lys His Asn Phe Phe
Thr Pro Gly Asn Tyr Phe145 150 155 160Tyr Asn Gly Val Gly His Val
Thr Val Gln Tyr Glu Thr Val Leu Ala 165 170 175Ile Gly Leu Asn Gly
Val Lys Glu Lys Val Arg Lys Glu Met Glu Asn 180 185 190Cys His Phe
Gly Asp Ala Asp Tyr Ser Thr Lys Met Cys Phe Leu Glu 195 200 205Ser
Ile Leu Ile Ser Cys Asp Ala Val Ile Thr Tyr Ala Asn Arg Tyr 210 215
220Ala Lys Met Ala Glu Glu Met Ala Glu Lys Glu Thr Asp Ala Ala
Arg225 230 235 240Arg Gln Glu Leu Leu Thr Ile Ala Arg Val Cys Lys
Asn Val Pro Glu 245 250 255Phe Pro Ala Glu Ser Phe Gln Glu Ala Cys
Gln Ser Phe Trp Phe Ile 260 265 270Gln Gln Val Leu Gln Ile Glu Ser
Ser Gly His Ser Ile Ser Pro Gly 275 280 285Arg Phe Asp Gln Tyr Met
Tyr Pro Tyr Tyr Glu Lys Asp Leu Lys Glu 290 295 300Gly Ser Leu Thr
Arg Glu Tyr Ala Gln Glu Leu Ile Asp Cys Ile Trp305 310 315 320Val
Lys Leu Asn Asp Leu Asn Lys Cys Arg Asp Ala Ala Ser Ala Glu 325 330
335Gly Phe Ala Gly Tyr Ser Leu Phe Gln Asn Leu Ile Val Gly Gly Gln
340 345 350Thr Val Gln Gly Arg Asp Ala Thr Asn Asp Leu Ser Phe Met
Cys Ile 355 360 365Thr Ala Ser Glu His Val Phe Leu Pro Met Pro Ser
Leu Ser Ile Arg 370 375 380Val Trp His Gly Ser Ser Lys Ala Leu Leu
Met Arg Ala Ala Glu Leu385 390 395 400Thr Arg Thr Gly Ile Gly Leu
Pro Ala Tyr Tyr Asn Asp Glu Val Ile 405 410 415Ile Pro Ala Leu Val
His Arg Gly Ala Thr Met Asp Glu Ala Arg Asn 420 425 430Tyr Asn Ile
Ile Gly Cys Val Glu Pro Gln Val Pro Gly Lys Thr Asp 435 440 445Gly
Trp His Asp Ala Ala Phe Phe Asn Met Cys Arg Pro Leu Glu Met 450 455
460Val Phe Ser Asn Gly Tyr Asp Asn Gly Glu Ile Ala Ser Ile Gln
Thr465 470 475 480Gly Asn Val Glu Ser Phe Gln Ser Phe Asp Glu Phe
Met Glu Ala Tyr 485 490 495Arg Lys Gln Met Leu Tyr Asn Ile Glu Leu
Met Val Asn Ala Asp Asn 500 505 510Ala Ile Asp Tyr Ala His Ala Lys
Leu Ala Pro Leu Pro Phe Glu Ser 515 520 525Cys Leu Val Asp Asp Cys
Ile Lys Arg Gly Met Ser Ala Gln Glu Gly 530 535 540Gly Ala Ile Tyr
Asn Phe Thr Gly Pro Gln Gly Phe Gly Ile Ala Asn545 550 555 560Val
Ala Asp Ser Leu Tyr Thr Ile Lys Lys Leu Val Phe Glu Glu Lys 565 570
575Arg Ile Thr Met Gly Glu Leu Lys Lys Ala Leu Glu Met Asn Tyr Gly
580 585 590Lys Gly Leu Asp Ala Thr Thr Ala Gly Asp Ile Ala Met Gln
Val Ala 595 600 605Lys Gly Leu Lys Asp Ala Gly Gln Glu Val Gly Pro
Asp Val Ile Ala 610 615 620Asn Thr Ile Arg Gln Val Leu Glu Met Glu
Leu Pro Glu Asp Val Arg625 630 635 640Lys Arg Tyr Glu Glu Ile His
Glu Met Ile Leu Glu Leu Pro Lys Tyr 645 650 655Gly Asn Asp Ile Asp
Glu Val Asp Glu Leu Ala Arg Glu Ala Ala Tyr 660 665 670Phe Tyr Thr
Arg Pro Leu Glu Thr Phe Lys Asn Pro Arg Gly Gly Met 675 680 685Tyr
Gln Ala Gly Leu Tyr Pro Val Ser Ala Asn Val Pro Leu Gly Ala 690 695
700Gln Thr Gly Ala Thr Pro Asp Gly Arg Leu Ala His Thr Pro Val
Ala705 710 715 720Asp Gly Val Gly Pro Thr Ser Gly Phe Asp Ile Ser
Gly Pro Thr Ala 725 730 735Ser Cys Asn Ser Val Ala Lys Leu Asp His
Ala Ile Ala Ser Asn Gly 740 745 750Thr Leu Phe Asn Met Lys Met His
Pro Thr Ala Met Ala Gly Glu Lys 755 760 765Gly Leu Glu Ser Phe Ile
Ser Leu Ile Arg Gly Tyr Phe Asp Gln Gln 770 775 780Gly Met His Met
Gln Phe Asn Val Val Asp Arg Ala Thr Leu Leu Asp785 790 795 800Ala
Gln Ala His Pro Glu Lys Tyr Ser Gly Leu Ile Val Arg Val Ala 805 810
815Gly Tyr Ser Ala Leu Phe Thr Thr Leu Ser Lys Ser Leu Gln Asp Asp
820 825 830Ile Ile Lys Arg Thr Glu Gln Ala Asp Asn Arg 835
84033794DNARoseburia inulinivorans 33atgaaagaat atcttaatac
ttcaggtaga atatttgata tccagaggta ttctattcac 60gatggccctg gtgtgcgtac
aattgtgttt ctaaaaggtt gtgcccttag atgcagatgg 120tgctgtaatc
ctgaaagcca aagcttcgaa gttgaaacaa tgacgattaa tggaaaacct
180aaagtcatgg gtaaagatgt tacagtcgcc gaggttatga agacggtaga
aagagacatg 240ccttattacc ttcaatcagg tggtggtatc accttatcgg
gtggcgaatg tactttgcaa 300ccagaatttt cccttggcct attgagagct
gcaaaggatt tgggcatatc cacggcaata 360gagagcatgg cgtacgcaaa
gtacgaagta atagaaactc ttcttccgta tttggatacg 420tatttaatgg
acatcaaaca tatgaatcct gagaaacata aagaatacac tggtcatgat
480aacttgagga tgttagaaaa cgccttaaga gtcgcgcatt ctggtcagac
cgaactgatc 540atcagagtac ctgtcatccc aggattcaac gcaactgagc
aggaactact agatattgca 600aaattcgcag atacactgcc tggagttaga
caaatacaca tcttgccata tcataatttt 660ggtcagggta aatacgaagg
attgaacagg gactatccga tgggggacac tgagaaaccc 720tctaatgaac
agatgaaagc ttttcaagaa atgattcaaa agaacacttc cctacattgc
780caaatcggtg gtta 79434264PRTroseburia inulinivorans 34Met Lys Glu
Tyr Leu Asn Thr Ser Gly Arg Ile Phe Asp Ile Gln Arg1 5 10
15Tyr Ser Ile His Asp Gly Pro Gly Val Arg Thr Ile Val Phe Leu Lys
20 25 30Gly Cys Ala Leu Arg Cys Arg Trp Cys Cys Asn Pro Glu Ser Gln
Ser 35 40 45Phe Glu Val Glu Thr Met Thr Ile Asn Gly Lys Pro Lys Val
Met Gly 50 55 60Lys Asp Val Thr Val Ala Glu Val Met Lys Thr Val Glu
Arg Asp Met65 70 75 80Pro Tyr Tyr Leu Gln Ser Gly Gly Gly Ile Thr
Leu Ser Gly Gly Glu 85 90 95Cys Thr Leu Gln Pro Glu Phe Ser Leu Gly
Leu Leu Arg Ala Ala Lys 100 105 110Asp Leu Gly Ile Ser Thr Ala Ile
Glu Ser Met Ala Tyr Ala Lys Tyr 115 120 125Glu Val Ile Glu Thr Leu
Leu Pro Tyr Leu Asp Thr Tyr Leu Met Asp 130 135 140Ile Lys His Met
Asn Pro Glu Lys His Lys Glu Tyr Thr Gly His Asp145 150 155 160Asn
Leu Arg Met Leu Glu Asn Ala Leu Arg Val Ala His Ser Gly Gln 165 170
175Thr Glu Leu Ile Ile Arg Val Pro Val Ile Pro Gly Phe Asn Ala Thr
180 185 190Glu Gln Glu Leu Leu Asp Ile Ala Lys Phe Ala Asp Thr Leu
Pro Gly 195 200 205Val Arg Gln Ile His Ile Leu Pro Tyr His Asn Phe
Gly Gln Gly Lys 210 215 220Tyr Glu Gly Leu Asn Arg Asp Tyr Pro Met
Gly Asp Thr Glu Lys Pro225 230 235 240Ser Asn Glu Gln Met Lys Ala
Phe Gln Glu Met Ile Gln Lys Asn Thr 245 250 255Ser Leu His Cys Gln
Ile Gly Gly 260351047DNAAchromobacter xylosoxidans 35atgaaagctc
tggtttatca cggtgaccac aagatctcgc ttgaagacaa gcccaagccc 60acccttcaaa
agcccacgga tgtagtagta cgggttttga agaccacgat ctgcggcacg
120gatctcggca tctacaaagg caagaatcca gaggtcgccg acgggcgcat
cctgggccat 180gaaggggtag gcgtcatcga ggaagtgggc gagagtgtca
cgcagttcaa gaaaggcgac 240aaggtcctga tttcctgcgt cacttcttgc
ggctcgtgcg actactgcaa gaagcagctt 300tactcccatt gccgcgacgg
cgggtggatc ctgggttaca tgatcgatgg cgtgcaggcc 360gaatacgtcc
gcatcccgca tgccgacaac agcctctaca agatccccca gacaattgac
420gacgaaatcg ccgtcctgct gagcgacatc ctgcccaccg gccacgaaat
cggcgtccag 480tatgggaatg tccagccggg cgatgcggtg gctattgtcg
gcgcgggccc cgtcggcatg 540tccgtactgt tgaccgccca gttctactcc
ccctcgacca tcatcgtgat cgacatggac 600gagaatcgcc tccagctcgc
caaggagctc ggggcaacgc acaccatcaa ctccggcacg 660gagaacgttg
tcgaagccgt gcataggatt gcggcagagg gagtcgatgt tgcgatcgag
720gcggtgggca taccggcgac ttgggacatc tgccaggaga tcgtcaagcc
cggcgcgcac 780atcgccaacg tcggcgtgca tggcgtcaag gttgacttcg
agattcagaa gctctggatc 840aagaacctga cgatcaccac gggactggtg
aacacgaaca cgacgcccat gctgatgaag 900gtcgcctcga ccgacaagct
tccgttgaag aagatgatta cccatcgctt cgagctggcc 960gagatcgagc
acgcctatca ggtattcctc aatggcgcca aggagaaggc gatgaagatc
1020atcctctcga acgcaggcgc tgcctga 104736348PRTAchromobacter
xylosoxidans 36Met Lys Ala Leu Val Tyr His Gly Asp His Lys Ile Ser
Leu Glu Asp1 5 10 15Lys Pro Lys Pro Thr Leu Gln Lys Pro Thr Asp Val
Val Val Arg Val 20 25 30Leu Lys Thr Thr Ile Cys Gly Thr Asp Leu Gly
Ile Tyr Lys Gly Lys 35 40 45Asn Pro Glu Val Ala Asp Gly Arg Ile Leu
Gly His Glu Gly Val Gly 50 55 60Val Ile Glu Glu Val Gly Glu Ser Val
Thr Gln Phe Lys Lys Gly Asp65 70 75 80Lys Val Leu Ile Ser Cys Val
Thr Ser Cys Gly Ser Cys Asp Tyr Cys 85 90 95Lys Lys Gln Leu Tyr Ser
His Cys Arg Asp Gly Gly Trp Ile Leu Gly 100 105 110Tyr Met Ile Asp
Gly Val Gln Ala Glu Tyr Val Arg Ile Pro His Ala 115 120 125Asp Asn
Ser Leu Tyr Lys Ile Pro Gln Thr Ile Asp Asp Glu Ile Ala 130 135
140Val Leu Leu Ser Asp Ile Leu Pro Thr Gly His Glu Ile Gly Val
Gln145 150 155 160Tyr Gly Asn Val Gln Pro Gly Asp Ala Val Ala Ile
Val Gly Ala Gly 165 170 175Pro Val Gly Met Ser Val Leu Leu Thr Ala
Gln Phe Tyr Ser Pro Ser 180 185 190Thr Ile Ile Val Ile Asp Met Asp
Glu Asn Arg Leu Gln Leu Ala Lys 195 200 205Glu Leu Gly Ala Thr His
Thr Ile Asn Ser Gly Thr Glu Asn Val Val 210 215 220Glu Ala Val His
Arg Ile Ala Ala Glu Gly Val Asp Val Ala Ile Glu225 230 235 240Ala
Val Gly Ile Pro Ala Thr Trp Asp Ile Cys Gln Glu Ile Val Lys 245 250
255Pro Gly Ala His Ile Ala Asn Val Gly Val His Gly Val Lys Val Asp
260 265 270Phe Glu Ile Gln Lys Leu Trp Ile Lys Asn Leu Thr Ile Thr
Thr Gly 275 280 285Leu Val Asn Thr Asn Thr Thr Pro Met Leu Met Lys
Val Ala Ser Thr 290 295 300Asp Lys Leu Pro Leu Lys Lys Met Ile Thr
His Arg Phe Glu Leu Ala305 310 315 320Glu Ile Glu His Ala Tyr Gln
Val Phe Leu Asn Gly Ala Lys Glu Lys 325 330 335Ala Met Lys Ile Ile
Leu Ser Asn Ala Gly Ala Ala 340 345371188DNASaccharomyces
cerevisiae 37atgttgagaa ctcaagccgc cagattgatc tgcaactccc gtgtcatcac
tgctaagaga 60acctttgctt tggccacccg tgctgctgct tacagcagac cagctgcccg
tttcgttaag 120ccaatgatca ctacccgtgg tttgaagcaa atcaacttcg
gtggtactgt tgaaaccgtc 180tacgaaagag ctgactggcc aagagaaaag
ttgttggact acttcaagaa cgacactttt 240gctttgatcg gttacggttc
ccaaggttac ggtcaaggtt tgaacttgag agacaacggt 300ttgaacgtta
tcattggtgt ccgtaaagat ggtgcttctt ggaaggctgc catcgaagac
360ggttgggttc caggcaagaa cttgttcact gttgaagatg ctatcaagag
aggtagttac 420gttatgaact tgttgtccga tgccgctcaa tcagaaacct
ggcctgctat caagccattg 480ttgaccaagg gtaagacttt gtacttctcc
cacggtttct ccccagtctt caaggacttg 540actcacgttg aaccaccaaa
ggacttagat gttatcttgg ttgctccaaa gggttccggt 600agaactgtca
gatctttgtt caaggaaggt cgtggtatta actcttctta cgccgtctgg
660aacgatgtca ccggtaaggc tcacgaaaag gcccaagctt tggccgttgc
cattggttcc 720ggttacgttt accaaaccac tttcgaaaga gaagtcaact
ctgacttgta cggtgaaaga 780ggttgtttaa tgggtggtat ccacggtatg
ttcttggctc aatacgacgt cttgagagaa 840aacggtcact ccccatctga
agctttcaac gaaaccgtcg aagaagctac ccaatctcta 900tacccattga
tcggtaagta cggtatggat tacatgtacg atgcttgttc caccaccgcc
960agaagaggtg ctttggactg gtacccaatc ttcaagaatg ctttgaagcc
tgttttccaa 1020gacttgtacg aatctaccaa gaacggtacc gaaaccaaga
gatctttgga attcaactct 1080caacctgact acagagaaaa gctagaaaag
gaattagaca ccatcagaaa catggaaatc 1140tggaaggttg gtaaggaagt
cagaaagttg agaccagaaa accaataa 118838395PRTSaccharomyces cerevisiae
38Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Ile1
5 10 15Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr
Ser 20 25 30Arg Pro Ala Ala Arg Phe Val Lys Pro Met Ile Thr Thr Arg
Gly Leu 35 40 45Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr
Glu Arg Ala 50 55 60Asp Trp Pro Arg Glu Lys Leu Leu Asp Tyr Phe Lys
Asn Asp Thr Phe65 70 75 80Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr
Gly Gln Gly Leu Asn Leu 85 90 95Arg Asp Asn Gly Leu Asn Val Ile Ile
Gly Val Arg Lys Asp Gly Ala 100 105 110Ser Trp Lys Ala Ala Ile Glu
Asp Gly Trp Val Pro Gly Lys Asn Leu 115 120 125Phe Thr Val Glu Asp
Ala Ile Lys Arg Gly Ser Tyr Val Met Asn Leu 130 135 140Leu Ser Asp
Ala Ala Gln Ser Glu Thr Trp Pro Ala Ile Lys Pro Leu145 150 155
160Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val
165 170 175Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp
Val Ile 180 185 190Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg
Ser Leu Phe Lys 195 200 205Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala
Val Trp Asn Asp Val Thr 210 215 220Gly Lys Ala His Glu Lys Ala Gln
Ala Leu Ala Val Ala Ile Gly Ser225 230 235 240Gly Tyr Val Tyr Gln
Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 245 250 255Tyr Gly Glu
Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 260 265 270Ala
Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 275 280
285Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile
290 295 300Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr
Thr Ala305 310 315 320Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe
Lys Asn Ala Leu Lys 325 330 335Pro Val Phe Gln Asp Leu Tyr Glu Ser
Thr Lys Asn Gly Thr Glu Thr 340 345 350Lys Arg Ser Leu Glu Phe Asn
Ser Gln Pro Asp Tyr Arg Glu Lys Leu 355 360 365Glu Lys Glu Leu Asp
Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 370 375 380Lys Glu Val
Arg Lys Leu Arg Pro Glu Asn Gln385 390 395391485DNAVibrio cholerae
39atggcgaatt atttcaatac gctgaatctg cgtgaacagt tggatcaact tggtcgttgc
60cgttttatgg cgcgagaaga gtttgcaacc gaagctgatt acctaaaagg taagaaagtg
120gtgatcgtag gttgtggggc tcaaggccta aaccaaggcc tcaatatgcg
tgattcaggt 180ttggatgttt cttacgctct gcgtcaggct gcgattgatg
aacagcgtca gtcatttaag 240aatgccaaga ataatggctt caacgtgggt
agttatgaac aactcatccc aaccgcagat 300ttggtgatta acttgacgcc
agacaagcag cacaccagtg tggtcaatgc ggtgatgcct 360ctgatgaagc
aaggtgctgc cttgggttac tcacacggtt ttaatatcgt tgaagagggc
420atgcagatcc gtaaagacat cacggttgtg atggtggcac caaaatgtcc
gggtacggaa 480gttcgtgaag agtataagcg cggtttcggc gttcctactc
ttatcgcggt acaccctgaa 540aacgatccac aaggtgaagg ttgggaaatt
gctaaagcgt gggctgcggc aacgggtggc 600catcgtgcgg gctgtttagc
ttcttctttt gtggcggaag tgaaatccga tttgatgggt 660gagcaaacca
ttctctgcgg tatgctgcaa gcgggctcta tcgtttgtta cgagaaaatg
720gttgctgatg gcatcgaccc tggttatgcg ggcaagcttt tgcaatttgg
ttgggaaacc 780attaccgaag cactcaagtt tggcggtatt actcatatga
tggatcgcct gtctaaccct 840gcaaaaatca aagcgtttga gctgtctgaa
gagttgaaag atctgatgcg cccactgtac 900aacaagcata tggatgacat
catttctggc cacttctcta gcaccatgat ggcggattgg 960gcgaatgatg
ataaagactt attcggctgg cgtgcagaaa ccgctgagac gacctttgaa
1020aactatccaa caaccgacgt aaaaattgct gagcaagaat actttgataa
cggtattttg 1080atgattgcca tggtgcgtgc tggggttgag ttggcgtttg
aagcgatgac ggcttcaggc 1140atcatcgatg agtcggctta ctatgaatca
ctgcacgaac tcccactgat tgccaatacg 1200gtagcgcgta agcgtctgta
tgaaatgaac gtggtaatct ctgacactgc tgagtacggt 1260aactatctgt
ttgccaatgt ggcggtacca ctattgcgtg aaaagtttat gccgaaagtg
1320ggcactgatg tgattggtaa aggattaggc gtggtctcta atcaagttga
taacgcaacg 1380cttatcgaag taaacagcat catccgtaac catccggttg
agtatatcgg tgaagagcta 1440cgcggttaca tgaaagacat gaagcgcatc
gccgtgggtg attaa 148540494PRTVibrio cholerae 40Met Ala Asn Tyr Phe
Asn Thr Leu Asn Leu Arg Glu Gln Leu Asp Gln1 5 10 15Leu Gly Arg Cys
Arg Phe Met Ala Arg Glu Glu Phe Ala Thr Glu Ala 20 25 30Asp Tyr Leu
Lys Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 35 40 45Gly Leu
Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Val Ser 50 55 60Tyr
Ala Leu Arg Gln Ala Ala Ile Asp Glu Gln Arg Gln Ser Phe Lys65 70 75
80Asn Ala Lys Asn Asn Gly Phe Asn Val Gly Ser Tyr Glu Gln Leu Ile
85 90 95Pro Thr Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Gln His
Thr 100 105 110Ser Val Val Asn Ala Val Met Pro Leu Met Lys Gln Gly
Ala Ala Leu 115 120 125Gly Tyr Ser His Gly Phe Asn Ile Val Glu Glu
Gly Met Gln Ile Arg 130 135 140Lys Asp Ile Thr Val Val Met Val Ala
Pro Lys Cys Pro Gly Thr Glu145 150 155 160Val Arg Glu Glu Tyr Lys
Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 165 170 175Val His Pro Glu
Asn Asp Pro Gln Gly Glu Gly Trp Glu Ile Ala Lys 180 185 190Ala Trp
Ala Ala Ala Thr Gly Gly His Arg Ala Gly Cys Leu Ala Ser 195 200
205Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile
210 215 220Leu Cys Gly Met Leu Gln Ala Gly Ser Ile Val Cys Tyr Glu
Lys Met225 230 235 240Val Ala Asp Gly Ile Asp Pro Gly Tyr Ala Gly
Lys Leu Leu Gln Phe 245 250 255Gly Trp Glu Thr Ile Thr Glu Ala Leu
Lys Phe Gly Gly Ile Thr His 260 265 270Met Met Asp Arg Leu Ser Asn
Pro Ala Lys Ile Lys Ala Phe Glu Leu 275 280 285Ser Glu Glu Leu Lys
Asp Leu Met Arg Pro Leu Tyr Asn Lys His Met 290 295 300Asp Asp Ile
Ile Ser Gly His Phe Ser Ser Thr Met Met Ala Asp Trp305 310 315
320Ala Asn Asp Asp Lys Asp Leu Phe Gly Trp Arg Ala Glu Thr Ala Glu
325 330 335Thr Thr Phe Glu Asn Tyr Pro Thr Thr Asp Val Lys Ile Ala
Glu Gln 340 345 350Glu Tyr Phe Asp Asn Gly Ile Leu Met Ile Ala Met
Val Arg Ala Gly 355 360 365Val Glu Leu Ala Phe Glu Ala Met Thr Ala
Ser Gly Ile Ile Asp Glu 370 375 380Ser Ala Tyr Tyr Glu Ser Leu His
Glu Leu Pro Leu Ile Ala Asn Thr385 390 395 400Val Ala Arg Lys Arg
Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 405 410 415Ala Glu Tyr
Gly Asn Tyr Leu Phe Ala Asn Val Ala Val Pro Leu Leu 420 425 430Arg
Glu Lys Phe Met Pro Lys Val Gly Thr Asp Val Ile Gly Lys Gly 435 440
445Leu Gly Val Val Ser Asn Gln Val Asp Asn Ala Thr Leu Ile Glu Val
450 455 460Asn Ser Ile Ile Arg Asn His Pro Val Glu Tyr Ile Gly Glu
Glu Leu465 470 475 480Arg Gly Tyr Met Lys Asp Met Lys Arg Ile Ala
Val Gly Asp 485 490411014DNAPseudomonas aeruginosa 41atgcgcgttt
tctacgataa agactgtgac ctctcgatca tccagggcaa gaaagttgcc 60atcatcggct
acggctccca gggccacgcc catgcctgca acctgaagga ctccggcgtc
120gacgtcaccg tgggcctgcg tagcggctcc gccaccgtgg ccaaggccga
agcgcacggt 180ctgaaggttg ccgacgtgaa gaccgccgtc gccgcagccg
acgtggtcat gatcctcacc 240ccggacgagt tccagggccg cctgtacaag
gaagagatcg agccgaacct gaagaagggc 300gccaccctgg ccttcgctca
cggcttctcc atccactaca accaggtcgt cccgcgcgcc 360gacctcgacg
tgatcatgat cgcgccgaag gcaccgggtc acaccgtgcg ttccgagttc
420gtcaagggcg gtggcatccc tgacctgatc gccatctacc aggacgcttc
cggcaacgcc 480aagaacgtcg ccctgtccta cgcctgcggc gtcggcggcg
gtcgtaccgg tatcatcgaa 540accaccttca aggacgagac cgaaaccgac
ctgttcggtg agcaggccgt tctctgcggt 600ggttgcgtcg agctggtcaa
ggccggtttc gaaaccctgg tcgaagccgg ttacgcgccg 660gaaatggcct
acttcgagtg cctgcacgag ctgaagctga tcgtcgacct gatgtacgaa
720ggcggcatcg ccaacatgaa ctactccatc tccaacaatg ccgaatacgg
tgagtacgta 780accggtccgg aggtgatcaa cgccgagtcc cgtgctgcca
tgcgcaacgc cctgaagcgc 840atccaggacg gcgagtacgc gaaaatgttc
attaccgaag gtgcggccaa ctacccgtcg 900atgactgcct accgccgcaa
caacgccgct cacccgatcg agcagatcgg cgagaagctg 960cgcgcgatga
tgccgtggat cgcagccaac aagatcgtcg acaagagcaa gaac
101442338PRTPseudomonas aeruginosa 42Met Arg Val Phe Tyr Asp Lys
Asp Cys Asp Leu Ser Ile Ile Gln Gly1 5 10 15Lys Lys Val Ala Ile Ile
Gly Tyr Gly Ser Gln Gly His Ala His Ala 20 25 30Cys Asn Leu Lys Asp
Ser Gly Val Asp Val Thr Val Gly Leu Arg Ser 35 40 45Gly Ser Ala Thr
Val Ala Lys Ala Glu Ala His Gly Leu Lys Val Ala 50 55 60Asp Val Lys
Thr Ala Val Ala Ala Ala Asp Val Val Met Ile Leu Thr65 70 75 80Pro
Asp Glu Phe Gln Gly Arg Leu Tyr Lys Glu Glu Ile Glu Pro Asn 85 90
95Leu Lys Lys Gly Ala Thr Leu Ala Phe Ala His Gly Phe Ser Ile His
100 105 110Tyr Asn Gln Val Val Pro Arg Ala Asp Leu Asp Val Ile Met
Ile Ala 115 120 125Pro Lys Ala Pro Gly His Thr Val Arg Ser Glu Phe
Val Lys Gly Gly 130 135 140Gly Ile Pro Asp Leu Ile Ala Ile Tyr Gln
Asp Ala Ser Gly Asn Ala145 150 155 160Lys Asn Val Ala Leu Ser
Tyr
Ala Cys Gly Val Gly Gly Gly Arg Thr 165 170 175Gly Ile Ile Glu Thr
Thr Phe Lys Asp Glu Thr Glu Thr Asp Leu Phe 180 185 190Gly Glu Gln
Ala Val Leu Cys Gly Gly Cys Val Glu Leu Val Lys Ala 195 200 205Gly
Phe Glu Thr Leu Val Glu Ala Gly Tyr Ala Pro Glu Met Ala Tyr 210 215
220Phe Glu Cys Leu His Glu Leu Lys Leu Ile Val Asp Leu Met Tyr
Glu225 230 235 240Gly Gly Ile Ala Asn Met Asn Tyr Ser Ile Ser Asn
Asn Ala Glu Tyr 245 250 255Gly Glu Tyr Val Thr Gly Pro Glu Val Ile
Asn Ala Glu Ser Arg Ala 260 265 270Ala Met Arg Asn Ala Leu Lys Arg
Ile Gln Asp Gly Glu Tyr Ala Lys 275 280 285Met Phe Ile Thr Glu Gly
Ala Ala Asn Tyr Pro Ser Met Thr Ala Tyr 290 295 300Arg Arg Asn Asn
Ala Ala His Pro Ile Glu Gln Ile Gly Glu Lys Leu305 310 315 320Arg
Ala Met Met Pro Trp Ile Ala Ala Asn Lys Ile Val Asp Lys Ser 325 330
335Lys Asn431014DNAPseudomonas fluorescens 43atgaaagttt tctacgataa
agactgcgac ctgtcgatca tccaaggtaa gaaagttgcc 60atcatcggct acggttccca
gggccacgct caagcatgca acctgaagga ttccggcgta 120gacgtgactg
ttggcctgcg taaaggctcg gctaccgttg ccaaggctga agcccacggc
180ttgaaagtga ccgacgttgc tgcagccgtt gccggtgccg acttggtcat
gatcctgacc 240ccggacgagt tccagtccca gctgtacaag aacgaaatcg
agccgaacat caagaagggc 300gccactctgg ccttctccca cggcttcgcg
atccactaca accaggttgt gcctcgtgcc 360gacctcgacg tgatcatgat
cgcgccgaag gctccaggcc acaccgtacg ttccgagttc 420gtcaagggcg
gtggtattcc tgacctgatc gcgatctacc aggacgcttc cggcaacgcc
480aagaacgttg ccctgtccta cgccgcaggc gtgggcggcg gccgtaccgg
catcatcgaa 540accaccttca aggacgagac tgaaaccgac ctgttcggtg
agcaggctgt tctgtgtggc 600ggtaccgtcg agctggtcaa agccggtttc
gaaaccctgg ttgaagctgg ctacgctcca 660gaaatggcct acttcgagtg
cctgcacgaa ctgaagctga tcgttgacct catgtacgaa 720ggcggtatcg
ccaacatgaa ctactcgatc tccaacaacg ctgaatacgg cgagtacgtg
780actggtccag aagtcatcaa cgccgaatcc cgtcaggcca tgcgcaatgc
tctgaagcgc 840atccaggacg gcgaatacgc gaagatgttc atcagcgaag
gcgctaccgg ctacccatcg 900atgaccgcca agcgtcgtaa caacgctgct
cacggtatcg aaatcatcgg cgagcaactg 960cgctcgatga tgccttggat
cggtgccaac aaaatcgtcg acaaagccaa gaac 101444338PRTPseudomonas
fluorescens 44Met Lys Val Phe Tyr Asp Lys Asp Cys Asp Leu Ser Ile
Ile Gln Gly1 5 10 15Lys Lys Val Ala Ile Ile Gly Tyr Gly Ser Gln Gly
His Ala Gln Ala 20 25 30Cys Asn Leu Lys Asp Ser Gly Val Asp Val Thr
Val Gly Leu Arg Lys 35 40 45Gly Ser Ala Thr Val Ala Lys Ala Glu Ala
His Gly Leu Lys Val Thr 50 55 60Asp Val Ala Ala Ala Val Ala Gly Ala
Asp Leu Val Met Ile Leu Thr65 70 75 80Pro Asp Glu Phe Gln Ser Gln
Leu Tyr Lys Asn Glu Ile Glu Pro Asn 85 90 95Ile Lys Lys Gly Ala Thr
Leu Ala Phe Ser His Gly Phe Ala Ile His 100 105 110Tyr Asn Gln Val
Val Pro Arg Ala Asp Leu Asp Val Ile Met Ile Ala 115 120 125Pro Lys
Ala Pro Gly His Thr Val Arg Ser Glu Phe Val Lys Gly Gly 130 135
140Gly Ile Pro Asp Leu Ile Ala Ile Tyr Gln Asp Ala Ser Gly Asn
Ala145 150 155 160Lys Asn Val Ala Leu Ser Tyr Ala Ala Gly Val Gly
Gly Gly Arg Thr 165 170 175Gly Ile Ile Glu Thr Thr Phe Lys Asp Glu
Thr Glu Thr Asp Leu Phe 180 185 190Gly Glu Gln Ala Val Leu Cys Gly
Gly Thr Val Glu Leu Val Lys Ala 195 200 205Gly Phe Glu Thr Leu Val
Glu Ala Gly Tyr Ala Pro Glu Met Ala Tyr 210 215 220Phe Glu Cys Leu
His Glu Leu Lys Leu Ile Val Asp Leu Met Tyr Glu225 230 235 240Gly
Gly Ile Ala Asn Met Asn Tyr Ser Ile Ser Asn Asn Ala Glu Tyr 245 250
255Gly Glu Tyr Val Thr Gly Pro Glu Val Ile Asn Ala Glu Ser Arg Gln
260 265 270Ala Met Arg Asn Ala Leu Lys Arg Ile Gln Asp Gly Glu Tyr
Ala Lys 275 280 285Met Phe Ile Ser Glu Gly Ala Thr Gly Tyr Pro Ser
Met Thr Ala Lys 290 295 300Arg Arg Asn Asn Ala Ala His Gly Ile Glu
Ile Ile Gly Glu Gln Leu305 310 315 320Arg Ser Met Met Pro Trp Ile
Gly Ala Asn Lys Ile Val Asp Lys Ala 325 330 335Lys
Asn451014DNAartificial sequenceMutant of Pseudomonas fluorescens
ilvC coding region 45atgaaggtgt tttacgataa agactgcgat ctgagcatca
tccagggaaa gaaggttgct 60attataggat atggttccca aggacacgca caagccttga
acttgaaaga ttctggggtc 120gacgtgacag taggtctgta taaaggtgct
gctgatgcag caaaggctga agcacatggc 180tttaaagtca cagatgttgc
agcggctgtt gctggcgctg atttagtcat gattttaatt 240ccagatgaat
ttcaatcgca attgtacaaa aatgaaatag aaccaaacat taagaagggc
300gctaccttgg ccttcagtca tggatttgcc attcattaca atcaagtagt
ccccagggca 360gatttggacg ttattatgat tgcacctaag gctccggggc
atactgttag gagcgaattt 420gttaagggtg gtggtattcc agatttgatc
gctatatacc aagacgttag cggaaacgct 480aagaatgtag ctttaagcta
cgcagcagga gttggtggcg ggagaacggg tataatagaa 540accactttta
aagacgagac tgagacagat ttatttggag aacaagcggt tctgtgcgga
600ggaactgttg aattggttaa agcaggcttt gagacgcttg tcgaagcagg
gtacgctccc 660gaaatggcat acttcgaatg tctacatgaa ttgaagttga
tagtagactt aatgtatgaa 720ggtggtatag ctaatatgaa ctattccatt
tcaaataatg cagaatatgg tgagtatgtc 780accggacctg aagtcattaa
cgcagaatca agacaagcca tgagaaatgc cttgaaacgt 840atccaggacg
gtgaatacgc taagatgttc ataagtgaag gcgctacggg ttacccgagt
900atgactgcta aaagaagaaa caatgcagca catggtatcg aaattattgg
tgaacagtta 960aggtctatga tgccctggat cggtgctaat aagatcgtag
acaaggcgaa aaat 101446338PRTartificial sequencemutant of
Pseudomonas fluorescens protein 46Met Lys Val Phe Tyr Asp Lys Asp
Cys Asp Leu Ser Ile Ile Gln Gly1 5 10 15Lys Lys Val Ala Ile Ile Gly
Tyr Gly Ser Gln Gly His Ala Gln Ala 20 25 30Leu Asn Leu Lys Asp Ser
Gly Val Asp Val Thr Val Gly Leu Tyr Lys 35 40 45Gly Ala Ala Asp Ala
Ala Lys Ala Glu Ala His Gly Phe Lys Val Thr 50 55 60Asp Val Ala Ala
Ala Val Ala Gly Ala Asp Leu Val Met Ile Leu Ile65 70 75 80Pro Asp
Glu Phe Gln Ser Gln Leu Tyr Lys Asn Glu Ile Glu Pro Asn 85 90 95Ile
Lys Lys Gly Ala Thr Leu Ala Phe Ser His Gly Phe Ala Ile His 100 105
110Tyr Asn Gln Val Val Pro Arg Ala Asp Leu Asp Val Ile Met Ile Ala
115 120 125Pro Lys Ala Pro Gly His Thr Val Arg Ser Glu Phe Val Lys
Gly Gly 130 135 140Gly Ile Pro Asp Leu Ile Ala Ile Tyr Gln Asp Val
Ser Gly Asn Ala145 150 155 160Lys Asn Val Ala Leu Ser Tyr Ala Ala
Ala Val Gly Gly Gly Arg Thr 165 170 175Gly Ile Ile Glu Thr Thr Phe
Lys Asp Glu Thr Glu Thr Asp Leu Phe 180 185 190Gly Glu Gln Ala Val
Leu Cys Gly Gly Thr Val Glu Leu Val Lys Ala 195 200 205Gly Phe Glu
Thr Leu Val Glu Ala Gly Tyr Ala Pro Glu Met Ala Tyr 210 215 220Phe
Glu Cys Leu His Glu Leu Lys Leu Ile Val Asp Leu Met Tyr Glu225 230
235 240Gly Gly Ile Ala Asn Met Asn Tyr Ser Ile Ser Asn Asn Ala Glu
Tyr 245 250 255Gly Glu Tyr Val Thr Gly Pro Glu Val Ile Asn Ala Glu
Ser Arg Gln 260 265 270Ala Met Arg Asn Ala Leu Lys Arg Ile Gln Asp
Gly Glu Tyr Ala Lys 275 280 285Met Phe Ile Ser Glu Gly Ala Thr Gly
Tyr Pro Ser Met Thr Ala Lys 290 295 300Arg Arg Asn Asn Ala Ala His
Gly Ile Glu Ile Ile Gly Glu Gln Leu305 310 315 320Arg Ser Met Met
Pro Trp Ile Gly Ala Asn Lys Ile Val Asp Lys Ala 325 330 335Lys
Asn471758DNASaccharomyces cerevisiae 47atgggcttgt taacgaaagt
tgctacatct agacaattct ctacaacgag atgcgttgca 60aagaagctca acaagtactc
gtatatcatc actgaaccta agggccaagg tgcgtcccag 120gccatgcttt
atgccaccgg tttcaagaag gaagatttca agaagcctca agtcggggtt
180ggttcctgtt ggtggtccgg taacccatgt aacatgcatc tattggactt
gaataacaga 240tgttctcaat ccattgaaaa agcgggtttg aaagctatgc
agttcaacac catcggtgtt 300tcagacggta tctctatggg tactaaaggt
atgagatact cgttacaaag tagagaaatc 360attgcagact cctttgaaac
catcatgatg gcacaacact acgatgctaa catcgccatc 420ccatcatgtg
acaaaaacat gcccggtgtc atgatggcca tgggtagaca taacagacct
480tccatcatgg tatatggtgg tactatcttg cccggtcatc caacatgtgg
ttcttcgaag 540atctctaaaa acatcgatat cgtctctgcg ttccaatcct
acggtgaata tatttccaag 600caattcactg aagaagaaag agaagatgtt
gtggaacatg catgcccagg tcctggttct 660tgtggtggta tgtatactgc
caacacaatg gcttctgccg ctgaagtgct aggtttgacc 720attccaaact
cctcttcctt cccagccgtt tccaaggaga agttagctga gtgtgacaac
780attggtgaat acatcaagaa gacaatggaa ttgggtattt tacctcgtga
tatcctcaca 840aaagaggctt ttgaaaacgc cattacttat gtcgttgcaa
ccggtgggtc cactaatgct 900gttttgcatt tggtggctgt tgctcactct
gcgggtgtca agttgtcacc agatgatttc 960caaagaatca gtgatactac
accattgatc ggtgacttca aaccttctgg taaatacgtc 1020atggccgatt
tgattaacgt tggtggtacc caatctgtga ttaagtatct atatgaaaac
1080aacatgttgc acggtaacac aatgactgtt accggtgaca ctttggcaga
acgtgcaaag 1140aaagcaccaa gcctacctga aggacaagag attattaagc
cactctccca cccaatcaag 1200gccaacggtc acttgcaaat tctgtacggt
tcattggcac caggtggagc tgtgggtaaa 1260attaccggta aggaaggtac
ttacttcaag ggtagagcac gtgtgttcga agaggaaggt 1320gcctttattg
aagccttgga aagaggtgaa atcaagaagg gtgaaaaaac cgttgttgtt
1380atcagatatg aaggtccaag aggtgcacca ggtatgcctg aaatgctaaa
gccttcctct 1440gctctgatgg gttacggttt gggtaaagat gttgcattgt
tgactgatgg tagattctct 1500ggtggttctc acgggttctt aatcggccac
attgttcccg aagccgctga aggtggtcct 1560atcgggttgg tcagagacgg
cgatgagatt atcattgatg ctgataataa caagattgac 1620ctattagtct
ctgataagga aatggctcaa cgtaaacaaa gttgggttgc acctccacct
1680cgttacacaa gaggtactct atccaagtat gctaagttgg tttccaacgc
ttccaacggt 1740tgtgttttag atgcttga 175848585PRTSaccharomyces
cerevisiae 48Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe
Ser Thr Thr1 5 10 15Arg Cys Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr
Ile Ile Thr Glu 20 25 30Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu
Tyr Ala Thr Gly Phe 35 40 45Lys Lys Glu Asp Phe Lys Lys Pro Gln Val
Gly Val Gly Ser Cys Trp 50 55 60Trp Ser Gly Asn Pro Cys Asn Met His
Leu Leu Asp Leu Asn Asn Arg65 70 75 80Cys Ser Gln Ser Ile Glu Lys
Ala Gly Leu Lys Ala Met Gln Phe Asn 85 90 95Thr Ile Gly Val Ser Asp
Gly Ile Ser Met Gly Thr Lys Gly Met Arg 100 105 110Tyr Ser Leu Gln
Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 115 120 125Met Met
Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 130 135
140Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg
Pro145 150 155 160Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly
His Pro Thr Cys 165 170 175Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp
Ile Val Ser Ala Phe Gln 180 185 190Ser Tyr Gly Glu Tyr Ile Ser Lys
Gln Phe Thr Glu Glu Glu Arg Glu 195 200 205Asp Val Val Glu His Ala
Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 210 215 220Tyr Thr Ala Asn
Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr225 230 235 240Ile
Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala 245 250
255Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly
260 265 270Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn
Ala Ile 275 280 285Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala
Val Leu His Leu 290 295 300Val Ala Val Ala His Ser Ala Gly Val Lys
Leu Ser Pro Asp Asp Phe305 310 315 320Gln Arg Ile Ser Asp Thr Thr
Pro Leu Ile Gly Asp Phe Lys Pro Ser 325 330 335Gly Lys Tyr Val Met
Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 340 345 350Val Ile Lys
Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 355 360 365Thr
Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 370 375
380Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile
Lys385 390 395 400Ala Asn Gly His Leu Gln Ile Leu Tyr Gly Ser Leu
Ala Pro Gly Gly 405 410 415Ala Val Gly Lys Ile Thr Gly Lys Glu Gly
Thr Tyr Phe Lys Gly Arg 420 425 430Ala Arg Val Phe Glu Glu Glu Gly
Ala Phe Ile Glu Ala Leu Glu Arg 435 440 445Gly Glu Ile Lys Lys Gly
Glu Lys Thr Val Val Val Ile Arg Tyr Glu 450 455 460Gly Pro Arg Gly
Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser465 470 475 480Ala
Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 485 490
495Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val
500 505 510Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp
Gly Asp 515 520 525Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp
Leu Leu Val Ser 530 535 540Asp Lys Glu Met Ala Gln Arg Lys Gln Ser
Trp Val Ala Pro Pro Pro545 550 555 560Arg Tyr Thr Arg Gly Thr Leu
Ser Lys Tyr Ala Lys Leu Val Ser Asn 565 570 575Ala Ser Asn Gly Cys
Val Leu Asp Ala 580 585491713DNAStreptococcus mutans 49atgactgaca
aaaaaactct taaagactta agaaatcgta gttctgttta cgattcaatg 60gttaaatcac
ctaatcgtgc tatgttgcgt gcaactggta tgcaagatga agactttgaa
120aaacctatcg tcggtgtcat ttcaacttgg gctgaaaaca caccttgtaa
tatccactta 180catgactttg gtaaactagc caaagtcggt gttaaggaag
ctggtgcttg gccagttcag 240ttcggaacaa tcacggtttc tgatggaatc
gccatgggaa cccaaggaat gcgtttctcc 300ttgacatctc gtgatattat
tgcagattct attgaagcag ccatgggagg tcataatgcg 360gatgcttttg
tagccattgg cggttgtgat aaaaacatgc ccggttctgt tatcgctatg
420gctaacatgg atatcccagc catttttgct tacggcggaa caattgcacc
tggtaattta 480gacggcaaag atatcgattt agtctctgtc tttgaaggtg
tcggccattg gaaccacggc 540gatatgacca aagaagaagt taaagctttg
gaatgtaatg cttgtcccgg tcctggaggc 600tgcggtggta tgtatactgc
taacacaatg gcgacagcta ttgaagtttt gggacttagc 660cttccgggtt
catcttctca cccggctgaa tccgcagaaa agaaagcaga tattgaagaa
720gctggtcgcg ctgttgtcaa aatgctcgaa atgggcttaa aaccttctga
cattttaacg 780cgtgaagctt ttgaagatgc tattactgta actatggctc
tgggaggttc aaccaactca 840acccttcacc tcttagctat tgcccatgct
gctaatgtgg aattgacact tgatgatttc 900aatactttcc aagaaaaagt
tcctcatttg gctgatttga aaccttctgg tcaatatgta 960ttccaagacc
tttacaaggt cggaggggta ccagcagtta tgaaatatct ccttaaaaat
1020ggcttccttc atggtgaccg tatcacttgt actggcaaaa cagtcgctga
aaatttgaag 1080gcttttgatg atttaacacc tggtcaaaag gttattatgc
cgcttgaaaa tcctaaacgt 1140gaagatggtc cgctcattat tctccatggt
aacttggctc cagacggtgc cgttgccaaa 1200gtttctggtg taaaagtgcg
tcgtcatgtc ggtcctgcta aggtctttaa ttctgaagaa 1260gaagccattg
aagctgtctt gaatgatgat attgttgatg gtgatgttgt tgtcgtacgt
1320tttgtaggac caaagggcgg tcctggtatg cctgaaatgc tttccctttc
atcaatgatt 1380gttggtaaag ggcaaggtga aaaagttgcc cttctgacag
atggccgctt ctcaggtggt 1440acttatggtc ttgtcgtggg tcatatcgct
cctgaagcac aagatggcgg tccaatcgcc 1500tacctgcaaa caggagacat
agtcactatt gaccaagaca ctaaggaatt acactttgat 1560atctccgatg
aagagttaaa acatcgtcaa gagaccattg aattgccacc gctctattca
1620cgcggtatcc ttggtaaata tgctcacatc gtttcgtctg cttctagggg
agccgtaaca 1680gacttttgga agcctgaaga aactggcaaa aaa
171350571PRTStreptococcus mutans 50Met Thr Asp Lys Lys Thr Leu Lys
Asp Leu Arg Asn Arg Ser Ser Val1 5 10 15Tyr Asp Ser Met Val Lys Ser
Pro Asn Arg Ala Met Leu Arg Ala Thr 20 25 30Gly Met Gln Asp Glu Asp
Phe Glu Lys Pro Ile Val Gly Val Ile Ser 35 40 45Thr Trp Ala Glu Asn
Thr Pro Cys Asn Ile His Leu His Asp Phe Gly 50 55 60Lys Leu Ala Lys
Val Gly Val Lys Glu Ala Gly Ala Trp
Pro Val Gln65 70 75 80Phe Gly Thr Ile Thr Val Ser Asp Gly Ile Ala
Met Gly Thr Gln Gly 85 90 95Met Arg Phe Ser Leu Thr Ser Arg Asp Ile
Ile Ala Asp Ser Ile Glu 100 105 110Ala Ala Met Gly Gly His Asn Ala
Asp Ala Phe Val Ala Ile Gly Gly 115 120 125Cys Asp Lys Asn Met Pro
Gly Ser Val Ile Ala Met Ala Asn Met Asp 130 135 140Ile Pro Ala Ile
Phe Ala Tyr Gly Gly Thr Ile Ala Pro Gly Asn Leu145 150 155 160Asp
Gly Lys Asp Ile Asp Leu Val Ser Val Phe Glu Gly Val Gly His 165 170
175Trp Asn His Gly Asp Met Thr Lys Glu Glu Val Lys Ala Leu Glu Cys
180 185 190Asn Ala Cys Pro Gly Pro Gly Gly Cys Gly Gly Met Tyr Thr
Ala Asn 195 200 205Thr Met Ala Thr Ala Ile Glu Val Leu Gly Leu Ser
Leu Pro Gly Ser 210 215 220Ser Ser His Pro Ala Glu Ser Ala Glu Lys
Lys Ala Asp Ile Glu Glu225 230 235 240Ala Gly Arg Ala Val Val Lys
Met Leu Glu Met Gly Leu Lys Pro Ser 245 250 255Asp Ile Leu Thr Arg
Glu Ala Phe Glu Asp Ala Ile Thr Val Thr Met 260 265 270Ala Leu Gly
Gly Ser Thr Asn Ser Thr Leu His Leu Leu Ala Ile Ala 275 280 285His
Ala Ala Asn Val Glu Leu Thr Leu Asp Asp Phe Asn Thr Phe Gln 290 295
300Glu Lys Val Pro His Leu Ala Asp Leu Lys Pro Ser Gly Gln Tyr
Val305 310 315 320Phe Gln Asp Leu Tyr Lys Val Gly Gly Val Pro Ala
Val Met Lys Tyr 325 330 335Leu Leu Lys Asn Gly Phe Leu His Gly Asp
Arg Ile Thr Cys Thr Gly 340 345 350Lys Thr Val Ala Glu Asn Leu Lys
Ala Phe Asp Asp Leu Thr Pro Gly 355 360 365Gln Lys Val Ile Met Pro
Leu Glu Asn Pro Lys Arg Glu Asp Gly Pro 370 375 380Leu Ile Ile Leu
His Gly Asn Leu Ala Pro Asp Gly Ala Val Ala Lys385 390 395 400Val
Ser Gly Val Lys Val Arg Arg His Val Gly Pro Ala Lys Val Phe 405 410
415Asn Ser Glu Glu Glu Ala Ile Glu Ala Val Leu Asn Asp Asp Ile Val
420 425 430Asp Gly Asp Val Val Val Val Arg Phe Val Gly Pro Lys Gly
Gly Pro 435 440 445Gly Met Pro Glu Met Leu Ser Leu Ser Ser Met Ile
Val Gly Lys Gly 450 455 460Gln Gly Glu Lys Val Ala Leu Leu Thr Asp
Gly Arg Phe Ser Gly Gly465 470 475 480Thr Tyr Gly Leu Val Val Gly
His Ile Ala Pro Glu Ala Gln Asp Gly 485 490 495Gly Pro Ile Ala Tyr
Leu Gln Thr Gly Asp Ile Val Thr Ile Asp Gln 500 505 510Asp Thr Lys
Glu Leu His Phe Asp Ile Ser Asp Glu Glu Leu Lys His 515 520 525Arg
Gln Glu Thr Ile Glu Leu Pro Pro Leu Tyr Ser Arg Gly Ile Leu 530 535
540Gly Lys Tyr Ala His Ile Val Ser Ser Ala Ser Arg Gly Ala Val
Thr545 550 555 560Asp Phe Trp Lys Pro Glu Glu Thr Gly Lys Lys 565
570511647DNALactococcus lactis 51atgtatacag taggagatta cctattagac
cgattacacg agttaggaat tgaagaaatt 60tttggagtcc ctggagacta taacttacaa
tttttagatc aaattatttc ccacaaggat 120atgaaatggg tcggaaatgc
taatgaatta aatgcttcat atatggctga tggctatgct 180cgtactaaaa
aagctgccgc atttcttaca acctttggag taggtgaatt gagtgcagtt
240aatggattag caggaagtta cgccgaaaat ttaccagtag tagaaatagt
gggatcacct 300acatcaaaag ttcaaaatga aggaaaattt gttcatcata
cgctggctga cggtgatttt 360aaacacttta tgaaaatgca cgaacctgtt
acagcagctc gaactttact gacagcagaa 420aatgcaaccg ttgaaattga
ccgagtactt tctgcactat taaaagaaag aaaacctgtc 480tatatcaact
taccagttga tgttgctgct gcaaaagcag agaaaccctc actccctttg
540aaaaaggaaa actcaacttc aaatacaagt gaccaagaaa ttttgaacaa
aattcaagaa 600agcttgaaaa atgccaaaaa accaatcgtg attacaggac
atgaaataat tagttttggc 660ttagaaaaaa cagtcactca atttatttca
aagacaaaac tacctattac gacattaaac 720tttggtaaaa gttcagttga
tgaagccctc ccttcatttt taggaatcta taatggtaca 780ctctcagagc
ctaatcttaa agaattcgtg gaatcagccg acttcatctt gatgcttgga
840gttaaactca cagactcttc aacaggagcc ttcactcatc atttaaatga
aaataaaatg 900atttcactga atatagatga aggaaaaata tttaacgaaa
gaatccaaaa ttttgatttt 960gaatccctca tctcctctct cttagaccta
agcgaaatag aatacaaagg aaaatatatc 1020gataaaaagc aagaagactt
tgttccatca aatgcgcttt tatcacaaga ccgcctatgg 1080caagcagttg
aaaacctaac tcaaagcaat gaaacaatcg ttgctgaaca agggacatca
1140ttctttggcg cttcatcaat tttcttaaaa tcaaagagtc attttattgg
tcaaccctta 1200tggggatcaa ttggatatac attcccagca gcattaggaa
gccaaattgc agataaagaa 1260agcagacacc ttttatttat tggtgatggt
tcacttcaac ttacagtgca agaattagga 1320ttagcaatca gagaaaaaat
taatccaatt tgctttatta tcaataatga tggttataca 1380gtcgaaagag
aaattcatgg accaaatcaa agctacaatg atattccaat gtggaattac
1440tcaaaattac cagaatcgtt tggagcaaca gaagatcgag tagtctcaaa
aatcgttaga 1500actgaaaatg aatttgtgtc tgtcatgaaa gaagctcaag
cagatccaaa tagaatgtac 1560tggattgagt taattttggc aaaagaaggt
gcaccaaaag tactgaaaaa aatgggcaaa 1620ctatttgctg aacaaaataa atcataa
164752548PRTLactococcus lactis 52Met Tyr Thr Val Gly Asp Tyr Leu
Leu Asp Arg Leu His Glu Leu Gly1 5 10 15Ile Glu Glu Ile Phe Gly Val
Pro Gly Asp Tyr Asn Leu Gln Phe Leu 20 25 30Asp Gln Ile Ile Ser His
Lys Asp Met Lys Trp Val Gly Asn Ala Asn 35 40 45Glu Leu Asn Ala Ser
Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 50 55 60Ala Ala Ala Phe
Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val65 70 75 80Asn Gly
Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 85 90 95Val
Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 100 105
110His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu
115 120 125Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala
Thr Val 130 135 140Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu
Arg Lys Pro Val145 150 155 160Tyr Ile Asn Leu Pro Val Asp Val Ala
Ala Ala Lys Ala Glu Lys Pro 165 170 175Ser Leu Pro Leu Lys Lys Glu
Asn Ser Thr Ser Asn Thr Ser Asp Gln 180 185 190Glu Ile Leu Asn Lys
Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 195 200 205Ile Val Ile
Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 210 215 220Val
Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn225 230
235 240Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly
Ile 245 250 255Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe
Val Glu Ser 260 265 270Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu
Thr Asp Ser Ser Thr 275 280 285Gly Ala Phe Thr His His Leu Asn Glu
Asn Lys Met Ile Ser Leu Asn 290 295 300Ile Asp Glu Gly Lys Ile Phe
Asn Glu Arg Ile Gln Asn Phe Asp Phe305 310 315 320Glu Ser Leu Ile
Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 325 330 335Gly Lys
Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 340 345
350Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln
355 360 365Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe
Gly Ala 370 375 380Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile
Gly Gln Pro Leu385 390 395 400Trp Gly Ser Ile Gly Tyr Thr Phe Pro
Ala Ala Leu Gly Ser Gln Ile 405 410 415Ala Asp Lys Glu Ser Arg His
Leu Leu Phe Ile Gly Asp Gly Ser Leu 420 425 430Gln Leu Thr Val Gln
Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 435 440 445Pro Ile Cys
Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 450 455 460Ile
His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr465 470
475 480Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val
Ser 485 490 495Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met
Lys Glu Ala 500 505 510Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu
Leu Ile Leu Ala Lys 515 520 525Glu Gly Ala Pro Lys Val Leu Lys Lys
Met Gly Lys Leu Phe Ala Glu 530 535 540Gln Asn Lys
Ser545531644DNAartificial sequencecodon optimized L. lactis kivD
coding region for S. cerevisiae expression 53atgtatacag taggtgacta
tctgttggac agattacacg aattaggtat agaagaaata 60ttcggagtac caggtgacta
caatttgcaa tttctagatc aaattatttc acacaaagat 120atgaaatggg
tgggaaatgc taatgagtta aatgcctcct atatggccga cgggtacgca
180agaacgaaaa aggctgcggc attcttgact acatttggtg ttggcgaatt
atccgcagtt 240aatggcttag cgggctccta tgctgagaac ctgcctgttg
ttgagatcgt gggatctcct 300acctcgaaag tgcagaacga aggtaagttt
gttcaccata cgttggctga tggtgatttc 360aagcacttta tgaagatgca
cgaaccggtt actgctgcca ggactttatt gacagccgag 420aatgcaactg
ttgaaattga tagagtgttg tctgccttac taaaggaaag aaagccggtt
480tacatcaatt tacctgtaga tgtagctgcc gctaaggctg aaaaaccatc
cttgcctctt 540aagaaggaaa attccacgtc gaatacatct gatcaagaga
ttctgaacaa aatacaggaa 600agtctgaaga atgccaagaa accaattgta
atcacaggcc atgaaattat atcgttcggc 660ctagagaaga ctgttactca
gtttatttca aagactaagt tacctattac tactttgaac 720tttggtaaat
catctgttga tgaagcattg ccctcatttt tggggattta caacggtact
780ctgtcagagc caaacttgaa ggaatttgtg gaatctgctg attttattct
tatgttgggt 840gtaaagctta ccgattctag tacgggtgca tttactcacc
atcttaatga aaataaaatg 900atttccttga atatcgatga aggtaaaatt
ttcaacgaaa gaatccaaaa tttcgacttc 960gaatccctga tatcatctct
tcttgacttg tccgaaattg aatataaagg caagtacata 1020gataaaaagc
aagaagattt tgtaccttct aacgcgctgt tgtcacaaga tagactgtgg
1080caagctgtcg aaaatttgac ccaaagtaat gagacgatcg tggctgaaca
aggcacttct 1140ttcttcggtg cctcatctat atttctgaaa tcgaaatcac
attttattgg tcaacccttg 1200tggggatcta taggatacac tttccccgca
gctctaggca gccaaattgc agataaagaa 1260tctagacatt tattgtttat
cggagatgga tcattgcaac tgactgtcca agaattagga 1320ctagccatta
gagagaagat aaacccaatc tgctttatca ttaataacga tggttacacg
1380gttgagaggg aaattcatgg tccgaaccag agttataatg acattcctat
gtggaattac 1440tcaaaactgc cagaaagttt cggggcaacg gaagacagag
ttgtgtccaa aattgtgaga 1500acagaaaatg aattcgtatc cgtgatgaaa
gaagctcaag cagatccaaa taggatgtat 1560tggatagaac ttattctagc
aaaggagggt gcacctaaag ttttgaaaaa gatgggtaag 1620ttatttgcag
aacaaaacaa gagc 1644541146DNASaccharomyces cerevisiae 54atgagagctt
tggcatattt caagaagggt gatattcact tcactaatga tatccctagg 60ccagaaatcc
aaaccgacga tgaggttatt atcgacgtct cttggtgtgg gatttgtggc
120tcggatcttc acgagtactt ggatggtcca atcttcatgc ctaaagatgg
agagtgccat 180aaattatcca acgctgcttt acctctggca atgggccatg
agatgtcagg aattgtttcc 240aaggttggtc ctaaagtgac aaaggtgaag
gttggcgacc acgtggtcgt tgatgctgcc 300agcagttgtg cggacctgca
ttgctggcca cactccaaat tttacaattc caaaccatgt 360gatgcttgtc
agaggggcag tgaaaatcta tgtacccacg ccggttttgt aggactaggt
420gtgatcagtg gtggctttgc tgaacaagtc gtagtctctc aacatcacat
tatcccggtt 480ccaaaggaaa ttcctctaga tgtggctgct ttagttgagc
ctctttctgt cacctggcat 540gctgttaaga tttctggttt caaaaaaggc
agttcagcct tggttcttgg tgcaggtccc 600attgggttgt gtaccatttt
ggtacttaag ggaatggggg ctagtaaaat tgtagtgtct 660gaaattgcag
agagaagaat agaaatggcc aagaaactgg gcgttgaggt gttcaatccc
720tccaagcacg gtcataaatc tatagagata ctacgtggtt tgaccaagag
ccatgatggg 780tttgattaca gttatgattg ttctggtatt caagttactt
tcgaaacctc tttgaaggca 840ttaacattca aggggacagc caccaacatt
gcagtttggg gtccaaaacc tgtcccattc 900caaccaatgg atgtgactct
ccaagagaaa gttatgactg gttcgatcgg ctatgttgtc 960gaagccttcg
aagaagttgt tcgtgccatc cacaacggag acatcgccat ggaagattgt
1020aagcaactaa tcactggtaa gcaaaggatt gaggacggtt gggaaaaggg
attccaagag 1080ttgatggatc acaaggaatc caacgttaag attctattga
cgcctaacaa tcacggtgaa 1140atgaag 114655382PRTSaccharomyces
cerevisiae 55Met Arg Ala Leu Ala Tyr Phe Lys Lys Gly Asp Ile His
Phe Thr Asn1 5 10 15Asp Ile Pro Arg Pro Glu Ile Gln Thr Asp Asp Glu
Val Ile Ile Asp 20 25 30Val Ser Trp Cys Gly Ile Cys Gly Ser Asp Leu
His Glu Tyr Leu Asp 35 40 45Gly Pro Ile Phe Met Pro Lys Asp Gly Glu
Cys His Lys Leu Ser Asn 50 55 60Ala Ala Leu Pro Leu Ala Met Gly His
Glu Met Ser Gly Ile Val Ser65 70 75 80Lys Val Gly Pro Lys Val Thr
Lys Val Lys Val Gly Asp His Val Val 85 90 95Val Asp Ala Ala Ser Ser
Cys Ala Asp Leu His Cys Trp Pro His Ser 100 105 110Lys Phe Tyr Asn
Ser Lys Pro Cys Asp Ala Cys Gln Arg Gly Ser Glu 115 120 125Asn Leu
Cys Thr His Ala Gly Phe Val Gly Leu Gly Val Ile Ser Gly 130 135
140Gly Phe Ala Glu Gln Val Val Val Ser Gln His His Ile Ile Pro
Val145 150 155 160Pro Lys Glu Ile Pro Leu Asp Val Ala Ala Leu Val
Glu Pro Leu Ser 165 170 175Val Thr Trp His Ala Val Lys Ile Ser Gly
Phe Lys Lys Gly Ser Ser 180 185 190Ala Leu Val Leu Gly Ala Gly Pro
Ile Gly Leu Cys Thr Ile Leu Val 195 200 205Leu Lys Gly Met Gly Ala
Ser Lys Ile Val Val Ser Glu Ile Ala Glu 210 215 220Arg Arg Ile Glu
Met Ala Lys Lys Leu Gly Val Glu Val Phe Asn Pro225 230 235 240Ser
Lys His Gly His Lys Ser Ile Glu Ile Leu Arg Gly Leu Thr Lys 245 250
255Ser His Asp Gly Phe Asp Tyr Ser Tyr Asp Cys Ser Gly Ile Gln Val
260 265 270Thr Phe Glu Thr Ser Leu Lys Ala Leu Thr Phe Lys Gly Thr
Ala Thr 275 280 285Asn Ile Ala Val Trp Gly Pro Lys Pro Val Pro Phe
Gln Pro Met Asp 290 295 300Val Thr Leu Gln Glu Lys Val Met Thr Gly
Ser Ile Gly Tyr Val Val305 310 315 320Glu Ala Phe Glu Glu Val Val
Arg Ala Ile His Asn Gly Asp Ile Ala 325 330 335Met Glu Asp Cys Lys
Gln Leu Ile Thr Gly Lys Gln Arg Ile Glu Asp 340 345 350Gly Trp Glu
Lys Gly Phe Gln Glu Leu Met Asp His Lys Glu Ser Asn 355 360 365Val
Lys Ile Leu Leu Thr Pro Asn Asn His Gly Glu Met Lys 370 375
380561125DNAartificial sequencehorse ADH coding region codon
optimized for S. cerevisiae expression 56atgtcaacag ccggtaaagt
tattaagtgt aaagcggcag ttttgtggga agagaaaaag 60ccgtttagca tagaagaagt
agaagtagcg ccaccaaaag cacacgaggt tagaatcaag 120atggttgcca
ccggaatctg tagatccgac gaccatgtgg tgagtggcac tctagttact
180cctttgccag taatcgcggg acacgaggct gccggaatcg ttgaatccat
aggtgaaggt 240gttaccactg ttcgtcctgg tgataaagtg atcccactgt
tcactcctca atgtggtaag 300tgtagagtct gcaaacatcc tgagggtaat
ttctgcctta aaaatgattt gtctatgcct 360agaggtacta tgcaggatgg
tacaagcaga tttacatgca gagggaaacc tatacaccat 420ttccttggta
cttctacatt ttcccaatac acagtggtgg acgagatatc tgtcgctaaa
480atcgatgcag cttcaccact ggaaaaagtt tgcttgatag ggtgcggatt
ttccaccggt 540tacggttccg cagttaaagt tgcaaaggtt acacagggtt
cgacttgtgc agtattcggt 600ttaggaggag taggactaag cgttattatg
gggtgtaaag ctgcaggcgc agcgaggatt 660ataggtgtag acatcaataa
ggacaaattt gcaaaagcta aggaggtcgg ggctactgaa 720tgtgttaacc
ctcaagatta taagaaacca atacaagaag tccttactga aatgtcaaac
780ggtggagttg atttctcttt tgaagttata ggccgtcttg atactatggt
aactgcgttg 840tcctgctgtc aagaggcata tggagtcagt gtgatcgtag
gtgttcctcc tgattcacaa 900aatttgtcga tgaatcctat gctgttgcta
agcggtcgta catggaaggg agctatattt 960ggcggtttta agagcaagga
tagtgttcca aaacttgttg ccgactttat ggcgaagaag 1020tttgctcttg
atcctttaat tacacatgta ttgccattcg agaaaatcaa tgaagggttt
1080gatttgttaa gaagtggtga atctattcgt acaattttaa ctttt
112557375PRTEquus caballus 57Met Ser Thr Ala Gly Lys Val Ile Lys
Cys Lys Ala Ala Val Leu Trp1 5 10 15Glu Glu Lys Lys Pro Phe Ser Ile
Glu Glu Val Glu Val Ala Pro Pro 20 25 30Lys Ala His Glu Val Arg Ile
Lys Met Val Ala Thr Gly Ile Cys Arg 35 40 45Ser Asp Asp His Val Val
Ser Gly Thr Leu Val Thr Pro Leu Pro
Val 50 55 60Ile Ala Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly
Glu Gly65 70 75 80Val Thr Thr Val Arg Pro Gly Asp Lys Val Ile Pro
Leu Phe Thr Pro 85 90 95Gln Cys Gly Lys Cys Arg Val Cys Lys His Pro
Glu Gly Asn Phe Cys 100 105 110Leu Lys Asn Asp Leu Ser Met Pro Arg
Gly Thr Met Gln Asp Gly Thr 115 120 125Ser Arg Phe Thr Cys Arg Gly
Lys Pro Ile His His Phe Leu Gly Thr 130 135 140Ser Thr Phe Ser Gln
Tyr Thr Val Val Asp Glu Ile Ser Val Ala Lys145 150 155 160Ile Asp
Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 165 170
175Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Gln
180 185 190Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu
Ser Val 195 200 205Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile
Ile Gly Val Asp 210 215 220Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys
Glu Val Gly Ala Thr Glu225 230 235 240Cys Val Asn Pro Gln Asp Tyr
Lys Lys Pro Ile Gln Glu Val Leu Thr 245 250 255Glu Met Ser Asn Gly
Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 260 265 270Leu Asp Thr
Met Val Thr Ala Leu Ser Cys Cys Gln Glu Ala Tyr Gly 275 280 285Val
Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 290 295
300Asn Pro Met Leu Leu Leu Ser Gly Arg Thr Trp Lys Gly Ala Ile
Phe305 310 315 320Gly Gly Phe Lys Ser Lys Asp Ser Val Pro Lys Leu
Val Ala Asp Phe 325 330 335Met Ala Lys Lys Phe Ala Leu Asp Pro Leu
Ile Thr His Val Leu Pro 340 345 350Phe Glu Lys Ile Asn Glu Gly Phe
Asp Leu Leu Arg Ser Gly Glu Ser 355 360 365Ile Arg Thr Ile Leu Thr
Phe 370 375581020DNALactococcus lactis 58atggcagtta caatgtatta
tgaagatgat gtagaagtat cagcacttgc tggaaagcaa 60attgcagtaa tcggttatgg
ttcacaagga catgctcacg cacagaattt gcgtgattct 120ggtcacaacg
ttatcattgg tgtgcgccac ggaaaatctt ttgataaagc aaaagaagat
180ggctttgaaa catttgaagt aggagaagca gtagctaaag ctgatgttat
tatggttttg 240gcaccagatg aacttcaaca atccatttat gaagaggaca
tcaaaccaaa cttgaaagca 300ggttcagcac ttggttttgc tcacggattt
aatatccatt ttggctatat taaagtacca 360gaagacgttg acgtctttat
ggttgcgcct aaggctccag gtcaccttgt ccgtcggact 420tatactgaag
gttttggtac accagctttg tttgtttcac accaaaatgc aagtggtcat
480gcgcgtgaaa tcgcaatgga ttgggccaaa ggaattggtt gtgctcgagt
gggaattatt 540gaaacaactt ttaaagaaga aacagaagaa gatttgtttg
gagaacaagc tgttctatgt 600ggaggtttga cagcacttgt tgaagccggt
tttgaaacac tgacagaagc tggatacgct 660ggcgaattgg cttactttga
agttttgcac gaaatgaaat tgattgttga cctcatgtat 720gaaggtggtt
ttactaaaat gcgtcaatcc atctcaaata ctgctgagtt tggcgattat
780gtgactggtc cacggattat tactgacgaa gttaaaaaga atatgaagct
tgttttggct 840gatattcaat ctggaaaatt tgctcaagat ttcgttgatg
acttcaaagc ggggcgtcca 900aaattaatag cctatcgcga agctgcaaaa
aatcttgaaa ttgaaaaaat tggggcagag 960ctacgtcaag caatgccatt
cacacaatct ggtgatgacg atgcctttaa aatctatcag 102059340PRTLactococcus
lactis 59Met Ala Val Thr Met Tyr Tyr Glu Asp Asp Val Glu Val Ser
Ala Leu1 5 10 15Ala Gly Lys Gln Ile Ala Val Ile Gly Tyr Gly Ser Gln
Gly His Ala 20 25 30His Ala Gln Asn Leu Arg Asp Ser Gly His Asn Val
Ile Ile Gly Val 35 40 45Arg His Gly Lys Ser Phe Asp Lys Ala Lys Glu
Asp Gly Phe Glu Thr 50 55 60Phe Glu Val Gly Glu Ala Val Ala Lys Ala
Asp Val Ile Met Val Leu65 70 75 80Ala Pro Asp Glu Leu Gln Gln Ser
Ile Tyr Glu Glu Asp Ile Lys Pro 85 90 95Asn Leu Lys Ala Gly Ser Ala
Leu Gly Phe Ala His Gly Phe Asn Ile 100 105 110His Phe Gly Tyr Ile
Lys Val Pro Glu Asp Val Asp Val Phe Met Val 115 120 125Ala Pro Lys
Ala Pro Gly His Leu Val Arg Arg Thr Tyr Thr Glu Gly 130 135 140Phe
Gly Thr Pro Ala Leu Phe Val Ser His Gln Asn Ala Ser Gly His145 150
155 160Ala Arg Glu Ile Ala Met Asp Trp Ala Lys Gly Ile Gly Cys Ala
Arg 165 170 175Val Gly Ile Ile Glu Thr Thr Phe Lys Glu Glu Thr Glu
Glu Asp Leu 180 185 190Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Leu
Thr Ala Leu Val Glu 195 200 205Ala Gly Phe Glu Thr Leu Thr Glu Ala
Gly Tyr Ala Gly Glu Leu Ala 210 215 220Tyr Phe Glu Val Leu His Glu
Met Lys Leu Ile Val Asp Leu Met Tyr225 230 235 240Glu Gly Gly Phe
Thr Lys Met Arg Gln Ser Ile Ser Asn Thr Ala Glu 245 250 255Phe Gly
Asp Tyr Val Thr Gly Pro Arg Ile Ile Thr Asp Glu Val Lys 260 265
270Lys Asn Met Lys Leu Val Leu Ala Asp Ile Gln Ser Gly Lys Phe Ala
275 280 285Gln Asp Phe Val Asp Asp Phe Lys Ala Gly Arg Pro Lys Leu
Ile Ala 290 295 300Tyr Arg Glu Ala Ala Lys Asn Leu Glu Ile Glu Lys
Ile Gly Ala Glu305 310 315 320Leu Arg Gln Ala Met Pro Phe Thr Gln
Ser Gly Asp Asp Asp Ala Phe 325 330 335Lys Ile Tyr Gln
34060719DNAArtificial sequenceUAS(PGK1)-FBA1 60aattaccgtc
gctcgtgatt tgtttgcaaa aagaacaaaa ctgaaaaaac ccagacacgc 60tcgacttcct
gtcttcctat tgattgcagc ttccaatttc gtcacacaac aaggtcctgc
120ctacttggct tcacatacgt tgcatacgtc gatatagata ataatgataa
tgacagcagg 180attatcgtaa tacgtaatag ttgaaaatct caaaaatgtg
tgggtcatta cgtaaataat 240gataggaatg ggattcttct atttttcctt
tttccattct agcagccgtc gggaaaacgt 300ggcatcctct ctttcgggct
caattggagt cacgctgccg tgagcatcct ctctttccat 360atctaacaac
tgagcacgta accaatggaa aagcatgagc ttagcgttgc tccaaaaaag
420tattggatgg ttaataccat ttgtctgttc tcttctgact ttgactcctc
aaaaaaaaaa 480aatctacaat caacagatcg cttcaattac gccctcacaa
aaactttttt ccttcttctt 540cgcccacgtt aaattttatc cctcatgttg
tctaacggat ttctgcactt gatttattat 600aaaaagacaa agacataata
cttctctatc aatttcagtt attgttcttc cttgcgttat 660tcttctgttc
ttctttttct tttgtcatat ataaccataa ccaagtaata catattcaa
71961636DNAArtificial sequencePromoter UAS(PGK1)-ENO2 61aattaccgtc
gctcgtgatt tgtttgcaaa aagaacaaaa ctgaaaaaac ccagacacgc 60tcgacttcct
gtcttcctat tgattgcagc ttccaatttc gtcacacaac aaggtcctgc
120ggcgttatgt cactaacgac gtgcaccaac ttgcggaaag tggaatcccg
ttccaaaact 180ggcatccact aattgataca tctacacacc gcacgccttt
tttctgaagc ccactttcgt 240ggactttgcc atatgcaaaa ttcatgaagt
gtgataccaa gtcagcatac acctcactag 300ggtagtttct ttggttgtat
tgatcatttg gttcatcgtg gttcattaat tttttttctc 360cattgctttc
tggctttgat cttactatca tttggatttt tgtcgaaggt tgtagaattg
420tatgtgacaa gtggcaccaa gcatatataa aaaaaaaaag cattatcttc
ctaccagagt 480tgattgttaa aaacgtattt atagcaaacg caattgtaat
taattcttat tttgtatctt 540ttcttccctt gtctcaatct tttattttta
ttttattttt cttttcttag tttctttcat 600aacaccaagc aactaatact
ataacataca ataata 63662979DNAArtificial sequencePromoter
UAS(FBA1)-PDC1 62tgacagcagg attatcgtaa tacgtaatag ttgaaaatct
caaaaatgtg tgggtcatta 60cgtaaataat gataggaatg ggattcttct atttttcctt
tttccattct cgcacgccga 120aatgcatgca agtaacctat tcaaagtaat
atctcataca tgtttcatga gggtaacaac 180atgcgactgg gtgagcatat
gttccgctga tgtgatgtgc aagataaaca agcaaggcag 240aaactaactt
cttcttcatg taataaacac accccgcgtt tatttaccta tctctaaact
300tcaacacctt atatcataac taatatttct tgagataagc acactgcacc
cataccttcc 360ttaaaaacgt agcttccagt ttttggtggt tccggcttcc
ttcccgattc cgcccgctaa 420acgcatattt ttgttgcctg gtggcatttg
caaaatgcat aacctatgca tttaaaagat 480tatgtatgct cttctgactt
ttcgtgtgat gaggctcgtg gaaaaaatga ataatttatg 540aatttgagaa
caattttgtg ttgttacggt attttactat ggaataatca atcaattgag
600gattttatgc aaatatcgtt tgaatatttt tccgaccctt tgagtacttt
tcttcataat 660tgcataatat tgtccgctgc ccctttttct gttagacggt
gtcttgatct acttgctatc 720gttcaacacc accttatttt ctaactattt
tttttttagc tcatttgaat cagcttatgg 780tgatggcaca tttttgcata
aacctagctg tcctcgttga acataggaaa aaaaaatata 840taaacaaggc
tctttcactc tccttgcaat cagatttggg tttgttccct ttattttcat
900atttcttgtc atattccttt ctcaattatt attttctact cataacctca
cgcaaaataa 960cacagtcaaa tcaatcaaa 97963994DNAArtificial
sequenceUAS(PGK1)-PDC1 63aattaccgtc gctcgtgatt tgtttgcaaa
aagaacaaaa ctgaaaaaac ccagacacgc 60tcgacttcct gtcttcctat tgattgcagc
ttccaatttc gtcacacaac aaggtcctgt 120cgacccgcac gccgaaatgc
atgcaagtaa cctattcaaa gtaatatctc atacatgttt 180catgagggta
acaacatgcg actgggtgag catatgttcc gctgatgtga tgtgcaagat
240aaacaagcaa ggcagaaact aacttcttct tcatgtaata aacacacccc
gcgtttattt 300acctatctct aaacttcaac accttatatc ataactaata
tttcttgaga taagcacact 360gcacccatac cttccttaaa aacgtagctt
ccagtttttg gtggttccgg cttccttccc 420gattccgccc gctaaacgca
tatttttgtt gcctggtggc atttgcaaaa tgcataacct 480atgcatttaa
aagattatgt atgctcttct gacttttcgt gtgatgaggc tcgtggaaaa
540aatgaataat ttatgaattt gagaacaatt ttgtgttgtt acggtatttt
actatggaat 600aatcaatcaa ttgaggattt tatgcaaata tcgtttgaat
atttttccga ccctttgagt 660acttttcttc ataattgcat aatattgtcc
gctgcccctt tttctgttag acggtgtctt 720gatctacttg ctatcgttca
acaccacctt attttctaac tatttttttt ttagctcatt 780tgaatcagct
tatggtgatg gcacattttt gcataaacct agctgtcctc gttgaacata
840ggaaaaaaaa atatataaac aaggctcttt cactctcctt gcaatcagat
ttgggtttgt 900tccctttatt ttcatatttc ttgtcatatt cctttctcaa
ttattatttt ctactcataa 960cctcacgcaa aataacacag tcaaatcaat caaa
99464731DNAArtificial sequenceUAS(PGK1)-OLE1 64aattaccgtc
gctcgtgatt tgtttgcaaa aagaacaaaa ctgaaaaaac ccagacacgc 60tcgacttcct
gtcttcctat tgattgcagc ttccaatttc gtcacacaac aaggtcctgt
120cgaccggggc gcccgtgcaa aaactaactc cgagcccggg catgtcccgg
gttagcgggc 180ccaacaaagg cgcttatctg gtgggcttcc gtagaagaaa
aaaagctgtt gagcgagcta 240tttcgggtat cccagccttc tctgcagacc
gccccagttg gcttggctct ggtgctgttc 300gttagcatca catcgcctgt
gacaggcaga ggtaataacg gcttaaggtt ctcttcgcat 360agtcggcagc
tttctttcgg acgttgaaca ctcaacaaac cttatctagt gcccaaccag
420gtgtgcttct acgagtcttg ctcactcaga cacacctatc cctattgtta
cggctatggg 480gatggcacac aaaggtggaa ataatagtag ttaacaatat
atgcagcaaa tcatcggctc 540ctggctcatc gagtcttgca aatcagcata
tacatatata tatgggggca gatcttgatt 600catttattgt tctatttcca
tctttcctac ttctgtttcc gtttatattt tgtattacgt 660agaatagaac
atcatagtaa tagatagttg tggtgatcat attataaaca gcactaaaac
720attacaacaa a 73165500PRTSaccharomyces cerevisiae 65Met Thr Lys
Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu1 5 10 15Pro Asn
Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 20 25 30Lys
Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 35 40
45Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp
50 55 60Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr
Glu65 70 75 80Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu
Ser Lys Leu 85 90 95Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser
Ser Ile Glu Ala 100 105 110Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala
Arg Gly Asp Val Thr Ile 115 120 125Ala Ile Asn Cys Leu Arg Asp Ala
Ala Ala Tyr Ala Asp Lys Val Asn 130 135 140Gly Arg Thr Ile Asn Thr
Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu145 150 155 160Glu Pro Ile
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 165 170 175Met
Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 180 185
190Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe
195 200 205Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val
Asn Ile 210 215 220Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu
Thr Asn Asp Pro225 230 235 240Arg Ile Arg Lys Leu Ala Phe Thr Gly
Ser Thr Glu Val Gly Lys Ser 245 250 255Val Ala Val Asp Ser Ser Glu
Ser Asn Leu Lys Lys Ile Thr Leu Glu 260 265 270Leu Gly Gly Lys Ser
Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 275 280 285Lys Thr Leu
Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 290 295 300Ile
Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp305 310
315 320Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys
Val 325 330 335Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile
Thr Asn Arg 340 345 350Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp
Ile Gly Lys Lys Glu 355 360 365Gly Ala Lys Ile Leu Thr Gly Gly Glu
Lys Val Gly Asp Lys Gly Tyr 370 375 380Phe Ile Arg Pro Thr Val Phe
Tyr Asp Val Asn Glu Asp Met Arg Ile385 390 395 400Val Lys Glu Glu
Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 405 410 415Thr Leu
Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 420 425
430Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala
435 440 445Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn
Asp Phe 450 455 460Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser
Gly Tyr Gly Arg465 470 475 480Glu Met Gly Glu Glu Val Tyr His Ala
Tyr Thr Glu Val Lys Ala Val 485 490 495Arg Ile Lys Leu
50066343PRTArtificial sequenceAnaerostipes caccae KARI variant K9D3
66Met Glu Glu Cys Lys Met Ala Lys Ile Tyr Tyr Gln Glu Asp Cys Asn1
5 10 15Leu Ser Leu Leu Asp Gly Lys Thr Ile Ala Val Ile Gly Tyr Gly
Ser 20 25 30Gln Gly His Ala His Ala Leu Asn Ala Lys Glu Ser Gly Cys
Asn Val 35 40 45Ile Ile Gly Leu Tyr Glu Gly Ala Lys Asp Trp Lys Arg
Ala Glu Glu 50 55 60Gln Gly Phe Glu Val Tyr Thr Ala Ala Glu Ala Ala
Lys Lys Ala Asp65 70 75 80Ile Ile Met Ile Leu Ile Asn Asp Glu Lys
Gln Ala Thr Met Tyr Lys 85 90 95Asn Asp Ile Glu Pro Asn Leu Glu Ala
Gly Asn Met Leu Met Phe Ala 100 105 110His Gly Phe Asn Ile His Phe
Gly Cys Ile Val Pro Pro Lys Asp Val 115 120 125Asp Val Thr Met Ile
Ala Pro Lys Gly Pro Gly His Thr Val Arg Ser 130 135 140Glu Tyr Glu
Glu Gly Lys Gly Val Pro Cys Leu Val Ala Val Glu Gln145 150 155
160Asp Ala Thr Gly Lys Ala Leu Asp Met Ala Leu Ala Tyr Ala Leu Ala
165 170 175Ile Gly Gly Ala Arg Ala Gly Val Leu Glu Thr Thr Phe Arg
Thr Glu 180 185 190Thr Glu Thr Asp Leu Phe Gly Glu Gln Ala Val Leu
Cys Gly Gly Val 195 200 205Cys Ala Leu Met Gln Ala Gly Phe Glu Thr
Leu Val Glu Ala Gly Tyr 210 215 220Asp Pro Arg Asn Ala Tyr Phe Glu
Cys Ile His Glu Met Lys Leu Ile225 230 235 240Val Asp Leu Ile Tyr
Gln Ser Gly Phe Ser Gly Met Arg Tyr Ser Ile 245 250 255Ser Asn Thr
Ala Glu Tyr Gly Asp Tyr Ile Thr Gly Pro Lys Ile Ile 260 265 270Thr
Glu Asp Thr Lys Lys Ala Met Lys Lys Ile Leu Ser Asp Ile Gln 275 280
285Asp Gly Thr Phe Ala Lys Asp Phe Leu Val Asp Met Ser Asp Ala Gly
290 295 300Ser Gln Val His Phe Lys Ala Met Arg Lys Leu Ala Ser Glu
His Pro305 310 315 320Ala Glu Val Val Gly Glu Glu Ile Arg Ser Leu
Tyr Ser Trp Ser Asp 325 330 335Glu Asp Lys Leu Ile Asn Asn
34067343PRTArtificial sequenceAnaerostipes caccae KARI variant K9G9
67Met Glu Glu Cys Lys Met Ala Lys Ile Tyr Tyr Gln Glu Asp Cys Asn1
5 10 15Leu Ser Leu Leu Asp Gly Lys Thr Ile Ala Val Ile Gly Tyr Gly
Ser 20 25 30Gln Gly His Ala His Ala Leu Asn Ala Lys Glu Ser Gly Cys
Asn Val 35
40 45Ile Ile Gly Leu Tyr Glu Gly Ala Lys Glu Trp Lys Arg Ala Glu
Glu 50 55 60Gln Gly Phe Glu Val Tyr Thr Ala Ala Glu Ala Ala Lys Lys
Ala Asp65 70 75 80Ile Ile Met Ile Leu Ile Asn Asp Glu Lys Gln Ala
Thr Met Tyr Lys 85 90 95Asn Asp Ile Glu Pro Asn Leu Glu Ala Gly Asn
Met Leu Met Phe Ala 100 105 110His Gly Phe Asn Ile His Phe Gly Cys
Ile Val Pro Pro Lys Asp Val 115 120 125Asp Val Thr Met Ile Ala Pro
Lys Gly Pro Gly His Thr Val Arg Ser 130 135 140Glu Tyr Glu Glu Gly
Lys Gly Val Pro Cys Leu Val Ala Val Glu Gln145 150 155 160Asp Ala
Thr Gly Lys Ala Leu Asp Met Ala Leu Ala Tyr Ala Leu Ala 165 170
175Ile Gly Gly Ala Arg Ala Gly Val Leu Glu Thr Thr Phe Arg Thr Glu
180 185 190Thr Glu Thr Asp Leu Phe Gly Glu Gln Ala Val Leu Cys Gly
Gly Val 195 200 205Cys Ala Leu Met Gln Ala Gly Phe Glu Thr Leu Val
Glu Ala Gly Tyr 210 215 220Asp Pro Arg Asn Ala Tyr Phe Glu Cys Ile
His Glu Met Lys Leu Ile225 230 235 240Val Asp Leu Ile Tyr Gln Ser
Gly Phe Ser Gly Met Arg Tyr Ser Ile 245 250 255Ser Asn Thr Ala Glu
Tyr Gly Asp Tyr Ile Thr Gly Pro Lys Ile Ile 260 265 270Thr Glu Asp
Thr Lys Lys Ala Met Lys Lys Ile Leu Ser Asp Ile Gln 275 280 285Asp
Gly Thr Phe Ala Lys Asp Phe Leu Val Asp Met Ser Asp Ala Gly 290 295
300Ser Gln Val His Phe Lys Ala Met Arg Lys Leu Ala Ser Glu His
Pro305 310 315 320Ala Glu Val Val Gly Glu Glu Ile Arg Ser Leu Tyr
Ser Trp Ser Asp 325 330 335Glu Asp Lys Leu Ile Asn Asn
34068267PRTSaccharomyces cerevisiae 68Met Ser Gln Gly Arg Lys Ala
Ala Glu Arg Leu Ala Lys Lys Thr Val1 5 10 15Leu Ile Thr Gly Ala Ser
Ala Gly Ile Gly Lys Ala Thr Ala Leu Glu 20 25 30Tyr Leu Glu Ala Ser
Asn Gly Asp Met Lys Leu Ile Leu Ala Ala Arg 35 40 45Arg Leu Glu Lys
Leu Glu Glu Leu Lys Lys Thr Ile Asp Gln Glu Phe 50 55 60Pro Asn Ala
Lys Val His Val Ala Gln Leu Asp Ile Thr Gln Ala Glu65 70 75 80Lys
Ile Lys Pro Phe Ile Glu Asn Leu Pro Gln Glu Phe Lys Asp Ile 85 90
95Asp Ile Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Arg Val
100 105 110Gly Gln Ile Ala Thr Glu Asp Ile Gln Asp Val Phe Asp Thr
Asn Val 115 120 125Thr Ala Leu Ile Asn Ile Thr Gln Ala Val Leu Pro
Ile Phe Gln Ala 130 135 140Lys Asn Ser Gly Asp Ile Val Asn Leu Gly
Ser Ile Ala Gly Arg Asp145 150 155 160Ala Tyr Pro Thr Gly Ser Ile
Tyr Cys Ala Ser Lys Phe Ala Val Gly 165 170 175Ala Phe Thr Asp Ser
Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 180 185 190Val Ile Leu
Ile Ala Pro Gly Leu Val Glu Thr Glu Phe Ser Leu Val 195 200 205Arg
Tyr Arg Gly Asn Glu Glu Gln Ala Lys Asn Val Tyr Lys Asp Thr 210 215
220Thr Pro Leu Met Ala Asp Asp Val Ala Asp Leu Ile Val Tyr Ala
Thr225 230 235 240Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu
Ile Phe Pro Thr 245 250 255Asn Gln Ala Ser Pro His His Ile Phe Arg
Gly 260 265692073DNASaccharomyces cerevisiae 69atggaaggct
tcaatccggc tgacatagaa catgcgtcac cgattaattc atctgacagc 60cattcatcct
cctttgtata tgctctaccc aaaagtgcta gtgaatatgt agtcaaccat
120aatgagggtc gtgcaagtgc aagtggaaat ccagccgcag tgccgtctcc
cataatgaca 180ctgaatctca aaagcacaca ttccctcaat attgatcagc
atgttcatac ctcaacatcg 240ccgacggaaa ctattgggca tattcatcat
gtggaaaagc tgaatcaaaa caatttgatt 300catctggatc cagtacccaa
ctttgaagat aagtccgata ttaagccttg gttgcaaaag 360attttttatc
ctcaaggaat agaacttgtg atagaaaggt cggacgcatt taaagttgtc
420ttcaagtgta aagctgctaa aaggggaagg aacgcgagaa ggaaaagaaa
agataagccc 480aaaggacagg accacgaaga cgagaaatcc aagatcaatg
atgacgaatt agaatatgcg 540agtccttcta atgccacagt aaccaatggg
cctcaaacat cgcccgatca aacatcctcc 600ataaagccaa agaaaaaaag
atgtgtatcg aggtttaata actgtccgtt tagagtacga 660gctacttatt
cgttaaagag gaaaagatgg agcattgttg taatggacaa taaccattca
720catcagctaa agtttaaccc tgattccgaa gagtacaaaa aattcaaaga
aaaattaaga 780aaggataatg acgtagatgc aatcaagaaa ttcgacgaat
tggaatacag aactttggcc 840aatttgccca ttccaacagc tacaatcccc
tgtgattgtg gtttaacaaa tgaaatacaa 900agtttcaatg tcgtattgcc
cactaacagt aatgttactt catcagcatc ctcttcaact 960gtatcgtcca
tatcccttga ttcatcgaat gcatctaaaa ggccatgctt accctctgta
1020aataacaccg gtagtatcaa taccaataac gtaaggaaac cgaaaagcca
gtgtaagaat 1080aaagacacac tcttaaaaag aaccaccatg cagaactttc
tcacaactaa atcaaggctg 1140cgtaagaccg gtacgccaac atcttcgcaa
cactcatcta cagcattttc aggatatatt 1200gatgatcctt tcaatttgaa
tgaaatcttg ccactgccgg catccgattt caagctaaac 1260actgtaacaa
atttgaacga aattgacttt acgaacattt ttaccaaatc gccgcatcca
1320catagcgggt ctacccatcc aagacaagtc ttcgaccaat tggacgattg
ttcctctata 1380ctcttctctc cattaactac aaacacgaat aatgaatttg
aaggagagtc agatgatttt 1440gttcattctc catatttgaa ctcagaggca
gatttcagcc aaattcttag tagtgctccc 1500ccagtccatc atgacccaaa
tgaaacacat caggaaaacc aggatattat tgatagattt 1560gctaatagtt
cccaagaaca taatgagtat attctacaat atttgacgca ctccgatgct
1620gctaaccaca ataacatcgg cgttccaaac aacaattcac attcgctaaa
tactcagcat 1680aacgtttctg atctgggcaa ctcactttta agacaagaag
ctttagttgg cagctcttca 1740acaaaaatct tcgacgaatt gaaatttgta
caaaatggcc cacacggttc tcaacatcct 1800atagattttc aacatgttga
ccatcgtcat ctcagctcta atgaacctca agtacgatca 1860catcaatatg
gtccgcaaca gcagccaccg cagcaattgc aatatcacca aaatcagccc
1920cacgacggcc ataaccacga acagcaccaa acagtacaaa aggatatgca
aacgcatgaa 1980tcgctagaaa taatgggaaa cacattattg gaagagttca
aagacattaa aatggtgaac 2040ggcgagttga agtatgtgaa gccagaagat tag
207370690PRTSaccharomyces cerevisiae 70Met Glu Gly Phe Asn Pro Ala
Asp Ile Glu His Ala Ser Pro Ile Asn1 5 10 15Ser Ser Asp Ser His Ser
Ser Ser Phe Val Tyr Ala Leu Pro Lys Ser 20 25 30Ala Ser Glu Tyr Val
Val Asn His Asn Glu Gly Arg Ala Ser Ala Ser 35 40 45Gly Asn Pro Ala
Ala Val Pro Ser Pro Ile Met Thr Leu Asn Leu Lys 50 55 60Ser Thr His
Ser Leu Asn Ile Asp Gln His Val His Thr Ser Thr Ser65 70 75 80Pro
Thr Glu Thr Ile Gly His Ile His His Val Glu Lys Leu Asn Gln 85 90
95Asn Asn Leu Ile His Leu Asp Pro Val Pro Asn Phe Glu Asp Lys Ser
100 105 110Asp Ile Lys Pro Trp Leu Gln Lys Ile Phe Tyr Pro Gln Gly
Ile Glu 115 120 125Leu Val Ile Glu Arg Ser Asp Ala Phe Lys Val Val
Phe Lys Cys Lys 130 135 140Ala Ala Lys Arg Gly Arg Asn Ala Arg Arg
Lys Arg Lys Asp Lys Pro145 150 155 160Lys Gly Gln Asp His Glu Asp
Glu Lys Ser Lys Ile Asn Asp Asp Glu 165 170 175Leu Glu Tyr Ala Ser
Pro Ser Asn Ala Thr Val Thr Asn Gly Pro Gln 180 185 190Thr Ser Pro
Asp Gln Thr Ser Ser Ile Lys Pro Lys Lys Lys Arg Cys 195 200 205Val
Ser Arg Phe Asn Asn Cys Pro Phe Arg Val Arg Ala Thr Tyr Ser 210 215
220Leu Lys Arg Lys Arg Trp Ser Ile Val Val Met Asp Asn Asn His
Ser225 230 235 240His Gln Leu Lys Phe Asn Pro Asp Ser Glu Glu Tyr
Lys Lys Phe Lys 245 250 255Glu Lys Leu Arg Lys Asp Asn Asp Val Asp
Ala Ile Lys Lys Phe Asp 260 265 270Glu Leu Glu Tyr Arg Thr Leu Ala
Asn Leu Pro Ile Pro Thr Ala Thr 275 280 285Ile Pro Cys Asp Cys Gly
Leu Thr Asn Glu Ile Gln Ser Phe Asn Val 290 295 300Val Leu Pro Thr
Asn Ser Asn Val Thr Ser Ser Ala Ser Ser Ser Thr305 310 315 320Val
Ser Ser Ile Ser Leu Asp Ser Ser Asn Ala Ser Lys Arg Pro Cys 325 330
335Leu Pro Ser Val Asn Asn Thr Gly Ser Ile Asn Thr Asn Asn Val Arg
340 345 350Lys Pro Lys Ser Gln Cys Lys Asn Lys Asp Thr Leu Leu Lys
Arg Thr 355 360 365Thr Met Gln Asn Phe Leu Thr Thr Lys Ser Arg Leu
Arg Lys Thr Gly 370 375 380Thr Pro Thr Ser Ser Gln His Ser Ser Thr
Ala Phe Ser Gly Tyr Ile385 390 395 400Asp Asp Pro Phe Asn Leu Asn
Glu Ile Leu Pro Leu Pro Ala Ser Asp 405 410 415Phe Lys Leu Asn Thr
Val Thr Asn Leu Asn Glu Ile Asp Phe Thr Asn 420 425 430Ile Phe Thr
Lys Ser Pro His Pro His Ser Gly Ser Thr His Pro Arg 435 440 445Gln
Val Phe Asp Gln Leu Asp Asp Cys Ser Ser Ile Leu Phe Ser Pro 450 455
460Leu Thr Thr Asn Thr Asn Asn Glu Phe Glu Gly Glu Ser Asp Asp
Phe465 470 475 480Val His Ser Pro Tyr Leu Asn Ser Glu Ala Asp Phe
Ser Gln Ile Leu 485 490 495Ser Ser Ala Pro Pro Val His His Asp Pro
Asn Glu Thr His Gln Glu 500 505 510Asn Gln Asp Ile Ile Asp Arg Phe
Ala Asn Ser Ser Gln Glu His Asn 515 520 525Glu Tyr Ile Leu Gln Tyr
Leu Thr His Ser Asp Ala Ala Asn His Asn 530 535 540Asn Ile Gly Val
Pro Asn Asn Asn Ser His Ser Leu Asn Thr Gln His545 550 555 560Asn
Val Ser Asp Leu Gly Asn Ser Leu Leu Arg Gln Glu Ala Leu Val 565 570
575Gly Ser Ser Ser Thr Lys Ile Phe Asp Glu Leu Lys Phe Val Gln Asn
580 585 590Gly Pro His Gly Ser Gln His Pro Ile Asp Phe Gln His Val
Asp His 595 600 605Arg His Leu Ser Ser Asn Glu Pro Gln Val Arg Ser
His Gln Tyr Gly 610 615 620Pro Gln Gln Gln Pro Pro Gln Gln Leu Gln
Tyr His Gln Asn Gln Pro625 630 635 640His Asp Gly His Asn His Glu
Gln His Gln Thr Val Gln Lys Asp Met 645 650 655Gln Thr His Glu Ser
Leu Glu Ile Met Gly Asn Thr Leu Leu Glu Glu 660 665 670Phe Lys Asp
Ile Lys Met Val Asn Gly Glu Leu Lys Tyr Val Lys Pro 675 680 685Glu
Asp 690711251DNASaccharomyces cerevisiae 71atgaaagcaa agtcgatgaa
gagcataata tctgtgccaa tatcagtgtc taaaacaggg 60aaaatgaagt taacagcatc
tcccgataat ctagcatcta tgatgtctaa agaccaaaat 120aaacttattc
atttagaccc agttccgtct tttgaggaca ggcacgagat taaaccgtgg
180ctacagaaaa tattctatcc tcaaggaata gatatagtca tcgaaagatc
agatagtagc 240aaagttactt ttaagtgtag gtcagtacga tcgaaagtag
ggttgaaccc taaatccaaa 300ggttcctctt caagatccca tgcatgtcca
tttagaatta gagcagccta ctctgtgcgg 360ttacagaagt ggaacgtggt
tgttatgaat aacatacatt cacatgagct gagatttgat 420ttgattacta
aaacggatga ctataaaaag tttaaggaaa atcttcgtca gaagaacgac
480gaaaaagcca tcaaaacatt tgatgaatta gaatataaag caagtctaaa
cttaccactc 540gtcacaccaa ttatttcttg tgactgtggg ttaaccaagg
aaattgaagc tttcaataac 600atttttctcc cactatcaaa cccccctttg
acgtctaaaa aaaatttgct caaaacaaat 660aaaaactccg tttctaaaat
aaaatccaga cagatggata attcgaaacc taggccaagg 720ttgaaaacga
agttggatgc ggatctacat gataccggat ttttagacaa tttcaaaacg
780cggaattcct gtgtaaagat agagaaagaa gattctttaa cgaacttaaa
cgaaattgat 840tttacgaaca tgttttgcaa cgacaatttc atccaaaatt
acaaccaagg cctgatggaa 900cttttgacag aacctacacc aggtccttcg
tcctcttctt gtatacttcc ttcaacacca 960acgaggccct tgtcacaaag
caaaatggat atagccctgt cagaatcaac aacatcttca 1020ccaaatttta
tggaaacaga cgctccttat ggagatgaga tcattaaagt ttccaaagat
1080accaaaagca acgcaccaac tgctgataca gatattgcta cgaacttagg
caaagagaga 1140aacgaaaatt ttggcatgtt aaactacaac tacgaagcgt
tgcttcattt caacgatgag 1200cattttaatg aattaaattc tattgaccca
gccttaatat caaaatatta a 125172416PRTSaccharomyces cerevisiae 72Met
Lys Ala Lys Ser Met Lys Ser Ile Ile Ser Val Pro Ile Ser Val1 5 10
15Ser Lys Thr Gly Lys Met Lys Leu Thr Ala Ser Pro Asp Asn Leu Ala
20 25 30Ser Met Met Ser Lys Asp Gln Asn Lys Leu Ile His Leu Asp Pro
Val 35 40 45Pro Ser Phe Glu Asp Arg His Glu Ile Lys Pro Trp Leu Gln
Lys Ile 50 55 60Phe Tyr Pro Gln Gly Ile Asp Ile Val Ile Glu Arg Ser
Asp Ser Ser65 70 75 80Lys Val Thr Phe Lys Cys Arg Ser Val Arg Ser
Lys Val Gly Leu Asn 85 90 95Pro Lys Ser Lys Gly Ser Ser Ser Arg Ser
His Ala Cys Pro Phe Arg 100 105 110Ile Arg Ala Ala Tyr Ser Val Arg
Leu Gln Lys Trp Asn Val Val Val 115 120 125Met Asn Asn Ile His Ser
His Glu Leu Arg Phe Asp Leu Ile Thr Lys 130 135 140Thr Asp Asp Tyr
Lys Lys Phe Lys Glu Asn Leu Arg Gln Lys Asn Asp145 150 155 160Glu
Lys Ala Ile Lys Thr Phe Asp Glu Leu Glu Tyr Lys Ala Ser Leu 165 170
175Asn Leu Pro Leu Val Thr Pro Ile Ile Ser Cys Asp Cys Gly Leu Thr
180 185 190Lys Glu Ile Glu Ala Phe Asn Asn Ile Phe Leu Pro Leu Ser
Asn Pro 195 200 205Pro Leu Thr Ser Lys Lys Asn Leu Leu Lys Thr Asn
Lys Asn Ser Val 210 215 220Ser Lys Ile Lys Ser Arg Gln Met Asp Asn
Ser Lys Pro Arg Pro Arg225 230 235 240Leu Lys Thr Lys Leu Asp Ala
Asp Leu His Asp Thr Gly Phe Leu Asp 245 250 255Asn Phe Lys Thr Arg
Asn Ser Cys Val Lys Ile Glu Lys Glu Asp Ser 260 265 270Leu Thr Asn
Leu Asn Glu Ile Asp Phe Thr Asn Met Phe Cys Asn Asp 275 280 285Asn
Phe Ile Gln Asn Tyr Asn Gln Gly Leu Met Glu Leu Leu Thr Glu 290 295
300Pro Thr Pro Gly Pro Ser Ser Ser Ser Cys Ile Leu Pro Ser Thr
Pro305 310 315 320Thr Arg Pro Leu Ser Gln Ser Lys Met Asp Ile Ala
Leu Ser Glu Ser 325 330 335Thr Thr Ser Ser Pro Asn Phe Met Glu Thr
Asp Ala Pro Tyr Gly Asp 340 345 350Glu Ile Ile Lys Val Ser Lys Asp
Thr Lys Ser Asn Ala Pro Thr Ala 355 360 365Asp Thr Asp Ile Ala Thr
Asn Leu Gly Lys Glu Arg Asn Glu Asn Phe 370 375 380Gly Met Leu Asn
Tyr Asn Tyr Glu Ala Leu Leu His Phe Asn Asp Glu385 390 395 400His
Phe Asn Glu Leu Asn Ser Ile Asp Pro Ala Leu Ile Ser Lys Tyr 405 410
41573363DNASaccharomyces cerevisiae 73atgacaggtg aaagaattga
aaaggtgaaa ataaatgacg aatttgcaaa atcacatttc 60ctaacaactc agtggagaga
aacaaagcgc caacgacact ataagatgcc cgttactgaa 120cagggactcc
gcgagaggat agaatcagcc ataccgcaag tttaccatat cattgtgacg
180gatctttcgt acggttgtgg tcagtcgttt gatattgtgg tggtcagcga
cttctttcaa 240ggtaaaagca aactaatgag gagtcgtgca gtgaacaagg
ctgtgaaaga agagctgcag 300gagattcatg cctttagctg caagtgctac
actgaggagg aatggtctaa gattgtggta 360tga 36374120PRTSaccharomyces
cerevisiae 74Met Thr Gly Glu Arg Ile Glu Lys Val Lys Ile Asn Asp
Glu Phe Ala1 5 10 15Lys Ser His Phe Leu Thr Thr Gln Trp Arg Glu Thr
Lys Arg Gln Arg 20 25 30His Tyr Lys Met Pro Val Thr Glu Gln Gly Leu
Arg Glu Arg Ile Glu 35 40 45Ser Ala Ile Pro Gln Val Tyr His Ile Ile
Val Thr Asp Leu Ser Tyr 50 55 60Gly Cys Gly Gln Ser Phe Asp Ile Val
Val Val Ser Asp Phe Phe Gln65 70 75 80Gly Lys Ser Lys Leu Met Arg
Ser Arg Ala Val Asn Lys Ala Val Lys 85 90 95Glu Glu Leu Gln Glu Ile
His Ala Phe Ser Cys Lys Cys Tyr Thr Glu 100 105 110Glu Glu Trp Ser
Lys Ile Val Val 115 12075858DNASaccharomyces cerevisiae
75atgtgttctt ttcaggttcc atctgcattt tcttttaact acacctcgta ctgttataaa
60cgccaccaag caagatatta cacagcagca aaactttttc aggaaatgcc tgttattgaa
120attaacgatc
aagagcaatt tacttaccta actaccactg cggccggcga caagttaatc
180gtgctttatt tccataccag ttgggcagaa ccatgcaaag cattaaagca
ggtttttgag 240gccattagta atgagccttc caattccaac gtctctttct
tatccattga tgcggacgaa 300aactcggaaa tttcagaact ttttgaaatc
tcagctgttc catattttat cataattcac 360aaagggacaa tcttaaaaga
attatccggc gcggatccaa aggagtatgt gtctttatta 420gaagactgca
agaactcagt caattccgga tcatcacaaa ctcatactat ggaaaatgca
480aacgtaaatg aggggagtca taatgatgaa gacgatgacg acgaagaaga
ggaagaagaa 540actgaggagc aaataaacgc tagattgact aaattggtca
atgccgcgcc ggtaatgtta 600tttatgaagg ggagcccctc tgaacctaaa
tgcgggtttt cgagacaact tgtgggtatc 660ttgagagaac atcaagtaag
atttggcttc tttgatatat taagagacga atctgttaga 720caaaacttga
aaaagttttc tgaatggcca actttccctc aactttatat aaatggggag
780tttcaaggcg gtttagacat tatcaaggaa tccttggagg aagaccctga
ttttttgcag 840catgctctcc aatcttaa 85876285PRTSaccharomyces
cerevisiae 76Met Cys Ser Phe Gln Val Pro Ser Ala Phe Ser Phe Asn
Tyr Thr Ser1 5 10 15Tyr Cys Tyr Lys Arg His Gln Ala Arg Tyr Tyr Thr
Ala Ala Lys Leu 20 25 30Phe Gln Glu Met Pro Val Ile Glu Ile Asn Asp
Gln Glu Gln Phe Thr 35 40 45Tyr Leu Thr Thr Thr Ala Ala Gly Asp Lys
Leu Ile Val Leu Tyr Phe 50 55 60His Thr Ser Trp Ala Glu Pro Cys Lys
Ala Leu Lys Gln Val Phe Glu65 70 75 80Ala Ile Ser Asn Glu Pro Ser
Asn Ser Asn Val Ser Phe Leu Ser Ile 85 90 95Asp Ala Asp Glu Asn Ser
Glu Ile Ser Glu Leu Phe Glu Ile Ser Ala 100 105 110Val Pro Tyr Phe
Ile Ile Ile His Lys Gly Thr Ile Leu Lys Glu Leu 115 120 125Ser Gly
Ala Asp Pro Lys Glu Tyr Val Ser Leu Leu Glu Asp Cys Lys 130 135
140Asn Ser Val Asn Ser Gly Ser Ser Gln Thr His Thr Met Glu Asn
Ala145 150 155 160Asn Val Asn Glu Gly Ser His Asn Asp Glu Asp Asp
Asp Asp Glu Glu 165 170 175Glu Glu Glu Glu Thr Glu Glu Gln Ile Asn
Ala Arg Leu Thr Lys Leu 180 185 190Val Asn Ala Ala Pro Val Met Leu
Phe Met Lys Gly Ser Pro Ser Glu 195 200 205Pro Lys Cys Gly Phe Ser
Arg Gln Leu Val Gly Ile Leu Arg Glu His 210 215 220Gln Val Arg Phe
Gly Phe Phe Asp Ile Leu Arg Asp Glu Ser Val Arg225 230 235 240Gln
Asn Leu Lys Lys Phe Ser Glu Trp Pro Thr Phe Pro Gln Leu Tyr 245 250
255Ile Asn Gly Glu Phe Gln Gly Gly Leu Asp Ile Ile Lys Glu Ser Leu
260 265 270Glu Glu Asp Pro Asp Phe Leu Gln His Ala Leu Gln Ser 275
280 28577969DNASaccharomyces cerevisiae 77atgtccattg tagcactaaa
gaacgcagtg gtgaccctta tacagaaagc gaaaggtagt 60ggtggaacct cagagttggg
ggggtctgaa tcaactccct tgttgagggg tagtaatagc 120aatagttcaa
ggcatgataa cttatcctca tctagctcgg atattatcta tggtagaaat
180tcagcgcagg atctagaaaa ctcaccgatg tcagtaggga aagataatag
gaatggcgat 240aacggttcgg ataacgaaaa ggcgaaccta gggttcttcc
aatcagtaga tcctcgcgta 300attagcgatt tgattatcgg gctaagcgac
ggtttaaccg tcccctttgc tctaacagct 360ggtctatctt cacttggtga
tgcgaaattg gtcattaccg gtggctttgc tgagttgatc 420tcaggtgcga
tttctatggg ccttggtggc tatttgggag cgaagagtga atctgattat
480tatcatgctg aagtaaagaa ggagaaaagg aaattttacg ataactccaa
cctaattaac 540agagaaattg aagacattct gttagagatt aaccctaatt
tctcggacga aacaatcgtt 600tcgttcatca aagatttaca aagaacacct
gagctaatgg ttgacttcat tatcaggtac 660ggtaggggtc tagacgaacc
tgccgagaat agagaactaa tcagtgcagt cactatcggt 720ggcggttatc
tacttggtgg gctagtacca ctagtgccat atttttttgt ctcagatgtg
780ggcacaggtc tcatttattc tataatagtc atggttgtaa cattattctg
gtttggttac 840gtaaagacaa aactatccat gggtagtggc agttcgactt
caaagaaagt tacggaaggt 900gttgaaatgg ttgttgtggg tggtgtagca
gcaggtgcgg cttggttctt tgttaagtta 960ctgggttaa
96978322PRTSaccharomyces cerevisiae 78Met Ser Ile Val Ala Leu Lys
Asn Ala Val Val Thr Leu Ile Gln Lys1 5 10 15Ala Lys Gly Ser Gly Gly
Thr Ser Glu Leu Gly Gly Ser Glu Ser Thr 20 25 30Pro Leu Leu Arg Gly
Ser Asn Ser Asn Ser Ser Arg His Asp Asn Leu 35 40 45Ser Ser Ser Ser
Ser Asp Ile Ile Tyr Gly Arg Asn Ser Ala Gln Asp 50 55 60Leu Glu Asn
Ser Pro Met Ser Val Gly Lys Asp Asn Arg Asn Gly Asp65 70 75 80Asn
Gly Ser Asp Asn Glu Lys Ala Asn Leu Gly Phe Phe Gln Ser Val 85 90
95Asp Pro Arg Val Ile Ser Asp Leu Ile Ile Gly Leu Ser Asp Gly Leu
100 105 110Thr Val Pro Phe Ala Leu Thr Ala Gly Leu Ser Ser Leu Gly
Asp Ala 115 120 125Lys Leu Val Ile Thr Gly Gly Phe Ala Glu Leu Ile
Ser Gly Ala Ile 130 135 140Ser Met Gly Leu Gly Gly Tyr Leu Gly Ala
Lys Ser Glu Ser Asp Tyr145 150 155 160Tyr His Ala Glu Val Lys Lys
Glu Lys Arg Lys Phe Tyr Asp Asn Ser 165 170 175Asn Leu Ile Asn Arg
Glu Ile Glu Asp Ile Leu Leu Glu Ile Asn Pro 180 185 190Asn Phe Ser
Asp Glu Thr Ile Val Ser Phe Ile Lys Asp Leu Gln Arg 195 200 205Thr
Pro Glu Leu Met Val Asp Phe Ile Ile Arg Tyr Gly Arg Gly Leu 210 215
220Asp Glu Pro Ala Glu Asn Arg Glu Leu Ile Ser Ala Val Thr Ile
Gly225 230 235 240Gly Gly Tyr Leu Leu Gly Gly Leu Val Pro Leu Val
Pro Tyr Phe Phe 245 250 255Val Ser Asp Val Gly Thr Gly Leu Ile Tyr
Ser Ile Ile Val Met Val 260 265 270Val Thr Leu Phe Trp Phe Gly Tyr
Val Lys Thr Lys Leu Ser Met Gly 275 280 285Ser Gly Ser Ser Thr Ser
Lys Lys Val Thr Glu Gly Val Glu Met Val 290 295 300Val Val Gly Gly
Val Ala Ala Gly Ala Ala Trp Phe Phe Val Lys Leu305 310 315 320Leu
Gly79347PRTBeijerinkia indica 79Met Lys Ala Leu Val Tyr Arg Gly Pro
Gly Gln Lys Leu Val Glu Glu1 5 10 15Arg Gln Lys Pro Glu Leu Lys Glu
Pro Gly Asp Ala Ile Val Lys Val 20 25 30Thr Lys Thr Thr Ile Cys Gly
Thr Asp Leu His Ile Leu Lys Gly Asp 35 40 45Val Ala Thr Cys Lys Pro
Gly Arg Val Leu Gly His Glu Gly Val Gly 50 55 60Val Ile Glu Ser Val
Gly Ser Gly Val Thr Ala Phe Gln Pro Gly Asp65 70 75 80Arg Val Leu
Ile Ser Cys Ile Ser Ser Cys Gly Lys Cys Ser Phe Cys 85 90 95Arg Arg
Gly Met Phe Ser His Cys Thr Thr Gly Gly Trp Ile Leu Gly 100 105
110Asn Glu Ile Asp Gly Thr Gln Ala Glu Tyr Val Arg Val Pro His Ala
115 120 125Asp Thr Ser Leu Tyr Arg Ile Pro Ala Gly Ala Asp Glu Glu
Ala Leu 130 135 140Val Met Leu Ser Asp Ile Leu Pro Thr Gly Phe Glu
Cys Gly Val Leu145 150 155 160Asn Gly Lys Val Ala Pro Gly Ser Ser
Val Ala Ile Val Gly Ala Gly 165 170 175Pro Val Gly Leu Ala Ala Leu
Leu Thr Ala Gln Phe Tyr Ser Pro Ala 180 185 190Glu Ile Ile Met Ile
Asp Leu Asp Asp Asn Arg Leu Gly Leu Ala Lys 195 200 205Gln Phe Gly
Ala Thr Arg Thr Val Asn Ser Thr Gly Gly Asn Ala Ala 210 215 220Ala
Glu Val Lys Ala Leu Thr Glu Gly Leu Gly Val Asp Thr Ala Ile225 230
235 240Glu Ala Val Gly Ile Pro Ala Thr Phe Glu Leu Cys Gln Asn Ile
Val 245 250 255Ala Pro Gly Gly Thr Ile Ala Asn Val Gly Val His Gly
Ser Lys Val 260 265 270Asp Leu His Leu Glu Ser Leu Trp Ser His Asn
Val Thr Ile Thr Thr 275 280 285Arg Leu Val Asp Thr Ala Thr Thr Pro
Met Leu Leu Lys Thr Val Gln 290 295 300Ser His Lys Leu Asp Pro Ser
Arg Leu Ile Thr His Arg Phe Ser Leu305 310 315 320Asp Gln Ile Leu
Asp Ala Tyr Glu Thr Phe Gly Gln Ala Ala Ser Thr 325 330 335Gln Ala
Leu Lys Val Ile Ile Ser Met Glu Ala 340 345
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