U.S. patent application number 13/197488 was filed with the patent office on 2012-05-24 for systemic carnitine deficiency gene and uses thereof. This patent application is currently assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA. Invention is credited to Jun-Ichi Nezu, Asuka Ose, Akira Tsuji.
Application Number | 20120129184 13/197488 |
Document ID | / |
Family ID | 17240798 |
Filed Date | 2012-05-24 |
United States Patent Application | 20120129184 |
Kind Code | A1 |
Nezu; Jun-Ichi ; et al. | May 24, 2012 |
The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2 gene and its protein.
Inventors: | Nezu; Jun-Ichi; (Shizuoka, JP) ; Tsuji; Akira; (Ishikawa, JP) ; Ose; Asuka; (Chiba, JP) |
Assignee: | CHUGAI SEIYAKU KABUSHIKI
KAISHA Tokyo JP |
Family ID: | 17240798 |
Appl. No.: | 13/197488 |
Filed: | August 3, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12193654 | Aug 18, 2008 | |||
13197488 | ||||
10940500 | Sep 13, 2004 | 7413860 | ||
12193654 | ||||
09798743 | Mar 2, 2001 | 6790831 | ||
10940500 | ||||
PCT/JP99/04853 | Sep 7, 1999 | |||
09798743 | ||||
Current U.S. Class: | 435/6.13 ; 435/29; 436/501 |
Current CPC Class: | C07K 14/47 20130101; A61K 38/00 20130101; Y10T 436/143333 20150115; A61K 48/00 20130101; C07K 14/705 20130101 |
Class at Publication: | 435/6.13 ; 436/501; 435/29 |
International Class: | C12Q 1/68 20060101 C12Q001/68; C12Q 1/02 20060101 C12Q001/02; G01N 33/566 20060101 G01N033/566 |
Date | Code | Application Number |
---|---|---|
Sep 7, 1998 | JP | 10252683 |
Sequence CWU 1
1
311557PRTHomo sapiens 1Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu
Gly Glu Trp Gly Pro1 5 10 15Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser
Ala Ser Ile Ile Pro Asn 20 25 30Gly Phe Thr Gly Leu Ser Ser Val Phe
Leu Ile Ala Thr Pro Glu His 35 40 45Arg Cys Arg Val Pro Asp Ala Ala
Asn Leu Ser Ser Ala Trp Arg Asn 50 55 60His Thr Val Pro Leu Arg Leu
Arg Asp Gly Arg Glu Val Pro His Ser65 70 75 80Cys Arg Arg Tyr Arg
Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly 85 90 95Leu Glu Pro Gly
Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser 100 105 110Cys Leu
Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Ile 115 120
125Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro Leu
130 135 140Thr Ile Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe
Ile Ser145 150 155 160Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn
Val Leu Phe Val Thr 165 170 175Met Gly Met Gln Thr Gly Phe Ser Phe
Leu Gln Ile Phe Ser Lys Asn 180 185 190Phe Glu Met Phe Val Val Leu
Phe Val Leu Val Gly Met Gly Gln Ile 195 200 205Ser Asn Tyr Val Ala
Ala Phe Val Leu Gly Thr Glu Ile Leu Gly Lys 210 215 220Ser Val Arg
Ile Ile Phe Ser Thr Leu Gly Val Cys Ile Phe Tyr Ala225 230 235
240Phe Gly Tyr Met Val Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp
245 250 255Arg Met Leu Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys
Val Ala 260 265 270Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu
Ile Ser Gln Gly 275 280 285Arg Phe Glu Glu Ala Glu Val Ile Ile Arg
Lys Ala Ala Lys Ala Asn 290 295 300Gly Ile Val Val Pro Ser Thr Ile
Phe Asp Pro Ser Glu Leu Gln Asp305 310 315 320Leu Ser Ser Lys Lys
Gln Gln Ser His Asn Ile Leu Asp Leu Leu Arg 325 330 335Thr Trp Asn
Ile Arg Met Val Thr Ile Met Ser Ile Met Leu Trp Met 340 345 350Thr
Ile Ser Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu 355 360
365His Gly Asp Ile Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu Val
370 375 380Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro
Arg Arg385 390 395 400Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly
Ser Val Leu Leu Phe 405 410 415Met Gln Leu Val Pro Pro Asp Leu Tyr
Tyr Leu Ala Thr Val Leu Val 420 425 430Met Val Gly Lys Phe Gly Val
Thr Ala Ala Phe Ser Met Val Tyr Val 435 440 445Tyr Thr Ala Glu Leu
Tyr Pro Thr Val Val Arg Asn Met Gly Val Gly 450 455 460Val Ser Ser
Thr Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe465 470 475
480Val Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly
485 490 495Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro
Glu Ser 500 505 510Phe Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met
Leu Arg Val Lys 515 520 525Gly Met Lys His Arg Lys Thr Pro Ser His
Thr Arg Met Leu Lys Asp 530 535 540Gly Gln Glu Arg Pro Thr Ile Leu
Lys Ser Thr Ala Phe545 550 55521831DNAHomo sapiensCDS(124)..(1794)
2cggacggtct tgggtcgcct gctgcctggc ttgcctggtc ggcggcgggt gccccgcgcg
60cacgcgcaaa gcccgccgcg ttcccagacc ccaggccgcg ctctgtgggc ctctgagggc
120 ggc atg cgg gac tac gac gag gtg acc gcc ttc ctg ggc gag tgg ggg
168 Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly 1 5
10 15ccc ttc cag cgc ctc atc ttc ttc ctg ctc agc gcc agc atc atc
ccc 216Pro Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile
Pro 20 25 30aat ggc ttc acc ggc ctg tcc tcc gtg ttc ctg ata gcg acc
ccg gag 264Asn Gly Phe Thr Gly Leu Ser Ser Val Phe Leu Ile Ala Thr
Pro Glu 35 40 45cac cgc tgc cgg gtg ccg gac gcc gcg aac ctg agc agc
gcc tgg cgc 312His Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser
Ala Trp Arg 50 55 60aac cac act gtc cca ctg cgg ctg cgg gac ggc cgc
gag gtg ccc cac 360Asn His Thr Val Pro Leu Arg Leu Arg Asp Gly Arg
Glu Val Pro His 65 70 75agc tgc cgc cgc tac cgg ctc gcc acc atc gcc
aac ttc tcg gcg ctc 408Ser Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala
Asn Phe Ser Ala Leu80 85 90 95ggg ctg gag ccg ggg cgc gac gtg gac
ctg ggg cag ctg gag cag gag 456Gly Leu Glu Pro Gly Arg Asp Val Asp
Leu Gly Gln Leu Glu Gln Glu 100 105 110agc tgt ctg gat ggc tgg gag
ttc agt cag gac gtc tac ctg tcc acc 504Ser Cys Leu Asp Gly Trp Glu
Phe Ser Gln Asp Val Tyr Leu Ser Thr 115 120 125att gtg acc gag tgg
aac ctg gtg tgt gag gac gac tgg aag gcc cca 552Ile Val Thr Glu Trp
Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro 130 135 140ctc aca atc
tcc ttg ttc ttc gtg ggt gtg ctg ttg ggc tcc ttc att 600Leu Thr Ile
Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Ile 145 150 155tca
ggg cag ctg tca gac agg ttt ggc cgg aag aat gtg ctg ttc gtg 648Ser
Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Val160 165
170 175acc atg ggc atg cag aca ggc ttc agc ttc ctg cag atc ttc tcg
aag 696Thr Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser
Lys 180 185 190aat ttt gag atg ttt gtc gtg ctg ttt gtc ctt gta ggc
atg ggc cag 744Asn Phe Glu Met Phe Val Val Leu Phe Val Leu Val Gly
Met Gly Gln 195 200 205atc tcc aac tat gtg gca gca ttt gtc ctg ggg
aca gaa att ctt ggc 792Ile Ser Asn Tyr Val Ala Ala Phe Val Leu Gly
Thr Glu Ile Leu Gly 210 215 220aag tca gtt cgt ata ata ttc tct acg
tta gga gtg tgc ata ttt tat 840Lys Ser Val Arg Ile Ile Phe Ser Thr
Leu Gly Val Cys Ile Phe Tyr 225 230 235gca ttt ggc tac atg gtg ctg
cca ctg ttt gct tac ttc atc cga gac 888Ala Phe Gly Tyr Met Val Leu
Pro Leu Phe Ala Tyr Phe Ile Arg Asp240 245 250 255tgg cgg atg ctg
ctg gtg gcg ctg acg atg ccg ggg gtg ctg tgc gtg 936Trp Arg Met Leu
Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys Val 260 265 270gca ctc
tgg tgg ttc atc cct gag tcc ccc cga tgg ctc atc tct cag 984Ala Leu
Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln 275 280
285gga cga ttt gaa gag gca gag gtg atc atc cgc aag gct gcc aaa gcc
1032Gly Arg Phe Glu Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ala
290 295 300aat ggg att gtt gtg cct tcc act atc ttt gac ccg agt gag
tta caa 1080Asn Gly Ile Val Val Pro Ser Thr Ile Phe Asp Pro Ser Glu
Leu Gln 305 310 315gac cta agt tcc aag aag cag cag tcc cac aac att
ctg gat ctg ctt 1128Asp Leu Ser Ser Lys Lys Gln Gln Ser His Asn Ile
Leu Asp Leu Leu320 325 330 335cga acc tgg aat atc cgg atg gtc acc
atc atg tcc ata atg ctg tgg 1176Arg Thr Trp Asn Ile Arg Met Val Thr
Ile Met Ser Ile Met Leu Trp 340 345 350atg acc ata tca gtg ggc tat
ttt ggg ctt tcg ctt gat act cct aac 1224Met Thr Ile Ser Val Gly Tyr
Phe Gly Leu Ser Leu Asp Thr Pro Asn 355 360 365ttg cat ggg gac atc
ttt gtg aac tgc ttc ctt tca gcg atg gtt gaa 1272Leu His Gly Asp Ile
Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu 370 375 380gtc cca gca
tat gtg ttg gcc tgg ctg ctg ctg caa tat ttg ccc cgg 1320Val Pro Ala
Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg 385 390 395cgc
tat tcc atg gcc act gcc ctc ttc ctg ggt ggc agt gtc ctt ctc 1368Arg
Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly Ser Val Leu Leu400 405
410 415ttc atg cag ctg gta ccc cca gac ttg tat tat ttg gct aca gtc
ctg 1416Phe Met Gln Leu Val Pro Pro Asp Leu Tyr Tyr Leu Ala Thr Val
Leu 420 425 430gtg atg gtg ggc aag ttt gga gtc acg gct gcc ttt tcc
atg gtc tac 1464Val Met Val Gly Lys Phe Gly Val Thr Ala Ala Phe Ser
Met Val Tyr 435 440 445gtg tac aca gcc gag ctg tat ccc aca gtg gtg
aga aac atg ggt gtg 1512Val Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val
Arg Asn Met Gly Val 450 455 460gga gtc agc tcc aca gca tcc cgc ctg
ggc agc atc ctg tct ccc tac 1560Gly Val Ser Ser Thr Ala Ser Arg Leu
Gly Ser Ile Leu Ser Pro Tyr 465 470 475ttc gtt tac ctt ggt gcc tac
gac cgc ttc ctg ccc tac att ctc atg 1608Phe Val Tyr Leu Gly Ala Tyr
Asp Arg Phe Leu Pro Tyr Ile Leu Met480 485 490 495gga agt ctg acc
atc ctg aca gcc atc ctc acc ttg ttt ctc cca gag 1656Gly Ser Leu Thr
Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro Glu 500 505 510agc ttc
ggt acc cca ctc cca gac acc att gac cag atg cta aga gtc 1704Ser Phe
Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val 515 520
525aaa gga atg aaa cac aga aaa act cca agt cac aca agg atg tta aaa
1752Lys Gly Met Lys His Arg Lys Thr Pro Ser His Thr Arg Met Leu Lys
530 535 540gat ggt caa gaa agg ccc aca atc ctt aaa agc aca gcc ttc
1794Asp Gly Gln Glu Arg Pro Thr Ile Leu Lys Ser Thr Ala Phe 545 550
555taacatcgct tccagtaagg gagaaactga agaggaa 18313557PRTMus musculus
3Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro1 5
10 15Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro
Asn 20 25 30Gly Phe Asn Gly Met Ser Ile Val Phe Leu Ala Gly Thr Pro
Glu His 35 40 45Arg Cys Leu Val Pro His Thr Val Asn Leu Ser Ser Ala
Trp Arg Asn 50 55 60His Ser Ile Pro Leu Glu Thr Lys Asp Gly Arg Gln
Val Pro Gln Lys65 70 75 80Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala
Asn Phe Ser Glu Leu Gly 85 90 95Leu Glu Pro Gly Arg Asp Val Asp Leu
Glu Gln Leu Glu Gln Glu Ser 100 105 110Cys Leu Asp Gly Trp Glu Tyr
Asp Lys Asp Val Phe Leu Ser Thr Ile 115 120 125Val Thr Glu Trp Asp
Leu Val Cys Lys Asp Asp Trp Lys Ala Pro Leu 130 135 140Thr Thr Ser
Leu Phe Phe Val Gly Val Leu Met Gly Ser Phe Ile Ser145 150 155
160Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Leu Thr
165 170 175Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Val Phe Ser
Val Asn 180 185 190Phe Glu Met Phe Thr Val Leu Phe Val Leu Val Gly
Met Gly Gln Ile 195 200 205Ser Asn Tyr Val Ala Ala Phe Val Leu Gly
Thr Glu Ile Leu Ser Lys 210 215 220Ser Ile Arg Ile Ile Phe Ala Thr
Leu Gly Val Cys Ile Phe Tyr Ala225 230 235 240Phe Gly Phe Met Val
Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp 245 250 255Arg Met Leu
Leu Leu Ala Leu Thr Val Pro Gly Val Leu Cys Gly Ala 260 265 270Leu
Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Gly 275 280
285Arg Ile Lys Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ile Asn
290 295 300Gly Ile Val Ala Pro Ser Thr Ile Phe Asp Pro Ser Glu Leu
Gln Asp305 310 315 320Leu Asn Ser Thr Lys Pro Gln Leu His His Ile
Tyr Asp Leu Ile Arg 325 330 335Thr Arg Asn Ile Arg Val Ile Thr Ile
Met Ser Ile Ile Leu Trp Leu 340 345 350Thr Ile Ser Val Gly Tyr Phe
Gly Leu Ser Leu Asp Thr Pro Asn Leu 355 360 365His Gly Asp Ile Tyr
Val Asn Cys Phe Leu Leu Ala Ala Val Glu Val 370 375 380Pro Ala Tyr
Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg Arg385 390 395
400Tyr Ser Ile Ser Ala Ala Leu Phe Leu Gly Gly Ser Val Leu Leu Phe
405 410 415Met Gln Leu Val Pro Ser Glu Leu Phe Tyr Leu Ser Thr Ala
Leu Val 420 425 430Met Val Gly Lys Phe Gly Ile Thr Ser Ala Tyr Ser
Met Val Tyr Val 435 440 445Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val
Arg Asn Met Gly Val Gly 450 455 460Val Ser Ser Thr Ala Ser Arg Leu
Gly Ser Ile Leu Ser Pro Tyr Phe465 470 475 480Val Tyr Leu Gly Ala
Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly 485 490 495Ser Leu Thr
Ile Leu Thr Ala Ile Leu Thr Leu Phe Phe Pro Glu Ser 500 505 510Phe
Gly Val Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val Lys 515 520
525Gly Ile Lys Gln Trp Gln Ile Gln Ser Gln Thr Arg Met Gln Lys Asp
530 535 540Gly Glu Glu Ser Pro Thr Val Leu Lys Ser Thr Ala Phe545
550 55541888DNAMus musculusCDS(60)..(1730) 4ctcccgcgcc acggtgtccc
cttattccca tacgggcgct gtgggaggct gaggacggc 59atg cgg gac tac gac
gag gtg acc gcc ttc cta ggc gag tgg ggg ccc 107Met Arg Asp Tyr Asp
Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro1 5 10 15ttc cag cgc ctc
atc ttc ttc ctg ctc agc gcc agc atc atc ccc aat 155Phe Gln Arg Leu
Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn 20 25 30ggc ttc aat
ggt atg tcc atc gtg ttc ctg gcg ggg acc ccg gag cac 203Gly Phe Asn
Gly Met Ser Ile Val Phe Leu Ala Gly Thr Pro Glu His 35 40 45cgt tgc
ctt gtg cct cac acc gtg aac ctg agc agc gcg tgg cgc aac 251Arg Cys
Leu Val Pro His Thr Val Asn Leu Ser Ser Ala Trp Arg Asn 50 55 60cac
agt atc ccg ttg gag acg aag gac gga cga cag gtg cct cag aaa 299His
Ser Ile Pro Leu Glu Thr Lys Asp Gly Arg Gln Val Pro Gln Lys65 70 75
80tgc cgc cgc tac cga ctg gcc acc atc gcc aac ttc tct gag cta ggg
347Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Glu Leu Gly
85 90 95ctg gag ccg ggg cgg gac gtg gac ctg gag cag ctg gag cag gag
agc 395Leu Glu Pro Gly Arg Asp Val Asp Leu Glu Gln Leu Glu Gln Glu
Ser 100 105 110tgc ctg gat ggc tgg gag tac gac aag gac gtc ttc ctg
tcc acc atc 443Cys Leu Asp Gly Trp Glu Tyr Asp Lys Asp Val Phe Leu
Ser Thr Ile 115 120 125gtg aca gag tgg gac ctg gtg tgt aag gat gac
tgg aaa gcc cca ctc 491Val Thr Glu Trp Asp Leu Val Cys Lys Asp Asp
Trp Lys Ala Pro Leu 130 135 140acc acc tcc ttg ttt ttc gtg ggt gtg
ctg atg ggc tcc ttc att tca 539Thr Thr Ser Leu Phe Phe Val Gly Val
Leu Met Gly Ser Phe Ile Ser145 150 155 160gga cag ctc tca gac agg
ttt ggt cgc aag aat gtg ctg ttt ttg acc 587Gly Gln Leu Ser Asp Arg
Phe Gly Arg Lys Asn Val Leu Phe Leu Thr 165 170 175atg ggc atg cag
act ggc ttc agc ttc ctg cag gtc ttc tct gtg aac 635Met Gly Met Gln
Thr Gly Phe Ser Phe Leu Gln Val Phe Ser Val Asn 180 185 190ttc gag
atg ttt aca gtg ctt ttt gtc ctt gtt ggc atg ggt cag atc 683Phe Glu
Met Phe Thr Val Leu Phe Val Leu Val Gly Met Gly Gln Ile 195 200
205tcc aac tac gtg gca gca ttt gtc ctg gga aca gaa att ctt tcc aag
731Ser Asn Tyr Val Ala Ala Phe Val Leu Gly Thr Glu Ile Leu Ser Lys
210 215 220tca att cga att ata ttc gcc acc tta gga gtt tgc ata ttt
tat gcg 779Ser Ile Arg Ile Ile Phe Ala Thr Leu Gly Val Cys Ile Phe
Tyr Ala225 230 235 240ttt ggc ttc atg gtg ctg cca ctg ttt gca tac
ttc atc aga gac tgg 827Phe Gly Phe Met Val Leu Pro Leu Phe Ala Tyr
Phe Ile Arg Asp Trp 245 250
255agg atg ctg ctg ctg gcg ctc act gtg cca ggg gtg cta tgt ggg gct
875Arg Met Leu Leu Leu Ala Leu Thr Val Pro Gly Val Leu Cys Gly Ala
260 265 270ctc tgg tgg ttc atc cct gag tcc cca cga tgg ctc atc tct
caa ggc 923Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser
Gln Gly 275 280 285cga att aaa gag gca gag gtg atc atc cgc aaa gct
gcc aaa atc aat 971Arg Ile Lys Glu Ala Glu Val Ile Ile Arg Lys Ala
Ala Lys Ile Asn 290 295 300ggg att gtt gca cct tcc act atc ttc gat
cca agt gag tta caa gac 1019Gly Ile Val Ala Pro Ser Thr Ile Phe Asp
Pro Ser Glu Leu Gln Asp305 310 315 320tta aat tct acg aag cct cag
ttg cac cac att tat gat ctg atc cga 1067Leu Asn Ser Thr Lys Pro Gln
Leu His His Ile Tyr Asp Leu Ile Arg 325 330 335aca cgg aat atc agg
gtc atc acc atc atg tct ata atc ctg tgg ctg 1115Thr Arg Asn Ile Arg
Val Ile Thr Ile Met Ser Ile Ile Leu Trp Leu 340 345 350acc ata tca
gtg ggc tat ttt gga cta tct ctt gac act cct aac ttg 1163Thr Ile Ser
Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu 355 360 365cat
ggg gac atc tat gtg aac tgc ttc cta ctg gcg gct gtt gaa gtc 1211His
Gly Asp Ile Tyr Val Asn Cys Phe Leu Leu Ala Ala Val Glu Val 370 375
380cca gcc tat gtg ctg gcc tgg ctg ttg ttg cag tac ttg ccc cgg cga
1259Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg
Arg385 390 395 400tat tct atc tcg gct gcc ctt ttc ctg ggt ggc agt
gtc ctt ctc ttc 1307Tyr Ser Ile Ser Ala Ala Leu Phe Leu Gly Gly Ser
Val Leu Leu Phe 405 410 415atg cag ctg gtg cct tca gaa ttg ttt tac
ttg tcc act gcc ctg gtg 1355Met Gln Leu Val Pro Ser Glu Leu Phe Tyr
Leu Ser Thr Ala Leu Val 420 425 430atg gtg ggg aag ttt gga atc acc
tct gcc tac tcc atg gtc tat gtg 1403Met Val Gly Lys Phe Gly Ile Thr
Ser Ala Tyr Ser Met Val Tyr Val 435 440 445tac aca gct gag ctg tac
ccc act gtg gtc aga aac atg ggt gtg ggg 1451Tyr Thr Ala Glu Leu Tyr
Pro Thr Val Val Arg Asn Met Gly Val Gly 450 455 460gtc agc tcc aca
gca tcc cgc ctt ggc agc atc ctg tct ccc tac ttt 1499Val Ser Ser Thr
Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe465 470 475 480gtt
tac cta ggt gcc tat gat cgc ttc ctg cct tat att ctc atg gga 1547Val
Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly 485 490
495agt ctg acc atc ctg aca gct atc ctc acc ttg ttc ttc cct gag agc
1595Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Phe Pro Glu Ser
500 505 510ttt ggt gtc cct ctc cca gat acc att gac cag atg cta agg
gtc aaa 1643Phe Gly Val Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg
Val Lys 515 520 525gga ata aaa cag tgg caa atc caa agc cag aca aga
atg caa aaa gat 1691Gly Ile Lys Gln Trp Gln Ile Gln Ser Gln Thr Arg
Met Gln Lys Asp 530 535 540ggt gaa gaa agc cca aca gtc cta aag agc
aca gcc ttc taacaccctg 1740Gly Glu Glu Ser Pro Thr Val Leu Lys Ser
Thr Ala Phe545 550 555tccagaaggc aaaaaactga ttggaaacct tcatgttgtc
agaaatgctc tccatgactg 1800agggcttttc tgttctgtta accttgtgtc
taacatgctc atggattggg gcatctgtcc 1860tggagagtca ccttcctcta gggacacc
1888525871DNAHomo
sapiensexon(1)..(614)intron(615)..(8636)exon(8637)..(8740)intron(8741)..(-
14409)exon(14410)..(14564)intron(14565)..(15590)exon(15591)..(15762)intron-
(15763)..(17282)exon(17283)..(17409)intron(17410)..(19178)exon(19179)..(19-
279)intron(19280)..(20947)exon(20948)..(21162)intron(21163)..(22690)exon(2-
2691)..(22873)intron(22874)..(23934)exon(23935)..(24070)intron(24071)..(24-
443)exon(24444)..(25871) 5gcggcccagg cccggaacct tccctggtcg
tgcgccatat gtaaggccag ccgcggcagg 60accaaggcgg cggtgtcagc tcgcgagcct
accctccgcg gacggtcttg ggtcgcctgc 120tgcctggctt gcctggtcgg
cggcgggtgc cccgcgcgca cgcgcaaagc ccgccgcgtt 180cccagacccc
aggccgcgct ctgtgggcct ctgagggcgg catgcgggac tacgacgagg
240tgaccgcctt cctgggcgag tgggggccct tccagcgcct catcttcttc
ctgctcagcg 300ccagcatcat ccccaatggc ttcaccggcc tgtcctccgt
gttcctgata gcgaccccgg 360agcaccgctg ccgggtgccg gacgccgcga
acctgagcag cgcctggcgc aaccacactg 420tcccactgcg gctgcgggac
ggccgcgagg tgccccacag ctgccgccgc taccggctcg 480ccaccatcgc
caacttctcg gcgctcgggc tggagccggg gcgcgacgtg gacctggggc
540agctggagca ggagagctgt ctggatggct gggagttcag tcaggacgtc
tacctgtcca 600ccattgtgac cgaggtgggt gccggcccct gctggggctg
agaccagggc tcggaggacc 660tgtcgcggtc cttgaacccg agctcctctc
tcccagatgc gcactggacg ctgtcactcc 720ccctccccca acggtcaaca
ccctagcgat ggagaccctc cagccaggtg gcttgggaac 780gcttcacgag
gtgacctcca gccacagtgt gctcctccct gcacaggtgg tcagtctggc
840ctcccgtcct gatggccact ttgaagaggg taccaggaag gtcctggcgg
tccctgggcg 900atgctctatg gccctgtgtg tccaggactt actctagttg
gggttggggg tggtaagtag 960cagagccagg acttgggcca ggggctatcc
cgtttttcct ctagtctctt gatttctttt 1020tagaagagaa gaaatacttc
tctttcctga acttttaaaa gttaaataaa gcatgtgtat 1080acaactgcct
cttccctttt tcctctagtt actccttccc ctaccgtcca caacccaaaa
1140acgacaatct ggtcatgccc tgtaagtaat tgtttgcctt ttcccatggt
cagttgtcag 1200tctttttttt tttttttttt ttttgagaca gagtctccct
ctgtcaccag gctggagcgc 1260agtcgtgtgt tcttggctca ctgcaacctt
cgcagtcgtg cgttcttggc tcactgcaat 1320cttcgccttc cgggctcaag
tgattctcct gcctcagcct ccgagtagct gtgagccacg 1380acgcccagct
aatttttgtg tttttagtag agacggggtt tcaccgtgtt ggccaggatg
1440gtctcgatct cttgacctcg tgatctgcct gcttctgcct gcaaagctgg
gattacaacc 1500gtgagccacc acgccaggcc gtcagttgtc actctttaag
atccattcat ctgaagatgg 1560gttcagggtg acttgttgac ctggaatatt
ttctcaggta ttatgaggca aggctgtcgg 1620ccagatttag ttaaagcata
cagccttagg tcatagggtg tgggggagcc tttctcattt 1680ctcatcccct
tggattttcc ctctgggtgg ttttgtctgt cccctccgaa cctgttggag
1740cagttgttgg agctggatgt aggaacatga tgttaatgat gtatgtgttt
tgtgtctttt 1800ttagacactg gcactctagc tccctgaagt ttcagcagca
ttgagtaagt agccagtgag 1860tagccctcat tgatagatag gctcactaaa
tgtgcagatg accaattcgc aggttagaga 1920aggcttccca gaagaggagg
cctctcagtg agcctagggt gttcagctca gcataatagt 1980gagctgaagg
ccccaatgca gcagcaagaa accacccagc aggacggcgg agttcacaga
2040gaggggagag ttcatagaga gggagagtgc cacaggccct ggcacagctt
caagccctgc 2100tggatgttgg tgctgagcct cccctcctgg agcctcagag
gggcttacag gggctctgga 2160gatcccaact gtgttgcttc ttggcgtcat
cacccttcaa tggagtctga gagctaccct 2220gggagatcca agtgtgtgtg
catgtgtgtg ttttttcttt ttggaaattt gatgtcccca 2280gcatttggac
ctgctttctc cacatatatg tagtgggagt gtgaccggag ccccactggg
2340atttcttagc tagtgacata gcttcagtgt ccagaggcat catggcttga
caaaagaggc 2400actccttgga ggtagccaac tgtgctttct ggcccatgaa
tccacaggaa attggaactt 2460tcagttgcca caaatcctgg gtcctagcct
cacaggtggg tgtgttacct tcccggaagc 2520cagtgagtac tatgaaagca
gaggctgtcc ctgaggttgc aggcagaggc cacagagggg 2580aacatgacac
aggaatccct acaaattcta cttggggctg cctaaagaag agggaagtag
2640tgaagcaaga agaagcacat ggcatctctt ggagttttac attgacccct
gagggttccc 2700cggcttactc tagtcacttg ttcctgcttt gctgcctcca
tcccacattg ggctgagtga 2760tggtggcatt gatgagctcc caaaggccag
ctgtgccagg gggtctgacc ttatcttgct 2820gccaatgtca gccttttgtt
ttttaatatt tagactattt atttagctgt cttagcagtt 2880tcaaaggagt
tatgtgccct ttcacctact tatatgttgt cagtctttgc agggaggcca
2940gattaatgct tagatctttg ttttgggcta ctggaatgct tgacttgaag
ttcagagctg 3000cttgttccca ggtgaacagc tactgctgga agttgctgca
tcaacattct aatggctttt 3060tctatggcct gttgtctttc aacccaaacc
tggcctgctg aacactgcat ctagtcccat 3120gcctgctaaa tgtctctaag
cctgccctct gccccaaatc atacataaag gtgtttgtaa 3180gtacactggt
attgaattac tagtcatatt ttttccactg aagactggaa cctcaggtgt
3240cctgtttgga tttttttaat ttgttcaagt taaagtacat acatgtagta
ccaaactttg 3300tggtggattt agatctttgc gtcttcctca atttctgaca
caattctgga tgcagaggga 3360ggttctcagg aaaattttta ttgaatgagt
taatgaataa tttaagaaat catctctaaa 3420gtttgagaac taaagaaaaa
tagttcagtt cttagaaggg aaacttgagg gtggctgaaa 3480aggattgact
ggaatttttt aaaggaaatg tgactccccc tgcccactga ctggggcttt
3540gatgccacat ggatgtggaa tgaggtgttg ggattggcag agggaatctg
ctagcaatta 3600ataaataaat aaatattggc agggcgtggt ggctcacgcc
tgtaatccca gcactttggg 3660aagccaaggc agcaggtcac ttgaggtcgg
gagttcaaga ccagtctggc caacatggtg 3720aaactccatc tctactaaaa
atacaaaaat tagctgggtg tggtggcaca tgcctgtatt 3780cccagctact
tgggagactg aagcaggaga atcgcttgaa cccaggaggc gggctttgca
3840gtgaaccgag atcgagcctc tgcactctag cctgggcgac aaagcgagac
tccatctcaa 3900aagaataata ataatattaa taaataaaaa tgatttatga
ggtaaaagag ttttatgccc 3960ccatgttcca ggaatagttt ggtggtccac
atggttctcg gctggcctct cctctggccc 4020ctcagtcatc cctggggtac
tggggaatta gccaacccat catgcagtgc ttcttggcca 4080tggactgccc
catctgctgg aaacctgggt tgtttctgag gttgtctggg ctgtccgctc
4140tttggtttca ccatagctct gtccagccta tggacagaca ggttccttga
gaaacttccg 4200gctgggtgtg gtggctcatg cctgtaaacc cagcactttg
ggaggctgag gcaggtggat 4260cacaaggcag gagttcgaga ccagcctggc
caacatggtg aaacctcgtc tccgctaaaa 4320atacaaaaat tagccctgcg
tggtggcggg tgcctgtaat cccagctact cgggagggag 4380gctgaggcag
gagaatttct tgaacctggg aagtgggggt tgcagtagcc aagatcgcac
4440cattgcatgc cagcctgggt gacaagagca agactccgtc tcaaaaaaaa
aaaaagaaaa 4500agaaaagaaa cttccaagct gctctgcatc gccttgctct
ccacctgtct gcttctaaga 4560agccctcggc ccagtcctgg gtgggactcc
cactccctcc ccattgtcct ggactagctt 4620ttctatcagc cttatcttgt
gtagagacag atagtcttag aagatgagag agccctcact 4680gttatcccca
aagctgcctg gaggaaaagc cagagcaacc tgggagctgg gaccggggct
4740gactctgggc agcagagacc cgagagacct ggaacttgaa cctcactgtt
acgcctttgt 4800tgatttctct cactcagggg acacacagac cctcatccag
ccttttgcag ctatatggca 4860aggcagagaa gccacttgcg gggtcccgtg
gcccactatg cacgtacata gtagacacat 4920ctggccatga gtggtcagat
tgagccactc tctagctagc tgacacctgt catcctgggt 4980caaatttctg
acagttgaca caaagcaggg ggtcagggag ccaaaaaaaa aaatggccag
5040gtgtggtggc tcttgcctgt aatcccaggg ctttgggagg ccaaggtggg
cagataacct 5100gaggtcagag ttcaagacca gcctggtcaa catggcaaaa
ccccgtctct actaaaaata 5160caaaaattag ccaggctggt ggtgcatccc
tgtagtccca gccactcagg aggctgaggc 5220atgagaatca cttgaacccg
ggaggtggag gttgcagtga gccgagattg tgccactgca 5280ctccagcctg
ggagacagag caagactctg tttcaaaaga aaaaaaagag tattctggag
5340attgaagttc aggagttcag ggttcatctc gactttgggc agccaagcaa
gaactaaagt 5400ataccaagat gttgaaggtt gatacctttt tatttatcga
ttcattcact cacctatgta 5460ccaaagagct cctgagcctc tcttcgatac
agggggcact gccaggagtt gtagaggatg 5520tgatagcaaa gataggaaat
accttttctc tttgctctga caacggtggg gcaaggattc 5580atcattgatt
tcagcaggag gcaggataaa atgtgtgtag gaatatagga atacatggca
5640atcagtaaca tgtggtacct agcagcatgt ctgactgttg atacggtcag
gctaggtaca 5700tcccctcagg gaagaacttc tgtcttaggg gcacacaccc
tatctttttt cccttcctgc 5760caattcacag gtaagaacat ttagtcccag
ggaactatgt catctctcta cttctcataa 5820ctgaaaaagc agtgccaatt
atgtatgagg tataggagac acaattctcc ctctttttaa 5880aaatgtttaa
tagctttatt aaggtgtaaa tgacataaaa actgcatgta gctaaagcat
5940gcaatttggc acacatgtat ctctacaccc ttgaaaccat caccactaga
aaggtgcatt 6000tctccccagg aagaggggca agtctaggcc ctttgccaga
gttgctccca gattgttttc 6060aggttgggcc tgcattcaca gctcagccag
ctgaagggtg acagcattag actcgtgacc 6120caaatcttaa acccacacat
tccattttaa cattgatacc tgtgatcatc agccagtata 6180gcccatccca
tgtgccaggc ggaggcatca ataagctggt ctgtagcagc tttaatcaca
6240gctggggagc caggagctaa ggaatgctag actcctttgt aaacaattta
agtagggggt 6300acttagcctg gactctatgt gcttctcatc cacctcttct
cagggagatt ctggccaagt 6360cctggaacct actgcagtcc atctggtggt
tgacagatat gtggacggat tggcaggctg 6420ggacccaatc tatgtttgcc
cttgtgttca gttttgagac ctagcacctt tcctgatcct 6480gctcacagac
cccctgcggc caataggaaa gaagtgttaa tgcatatttg cttttggagg
6540gcccaaagcc aggcccagag agttgtcaag ggcggtcagt ggtgggtgga
tggcagagtt 6600aaccaaggag ttacacacct gcctagacta aggacaggct
ggaccaagta gagagggtgg 6660ggctaaggga gcctgagaga tgctctgggg
cctgtctcaa aatgagcact atagtcaccc 6720tgtcccctgc agagattgtc
tgacctggtt ttaggtcaca cccaaccttg ccagccaagg 6780agtctttaga
agcctgatat tgggagacct gtcctggggt ctacaacccc agaactcact
6840gcagaagccc acgtggattg ctagtctagc tcagccatat gggtccccaa
ccctcacctc 6900atgatagtcc tgtgagaaac cgctgctgac cctttgttca
tgttttcatc ttttccacta 6960taaaagacat gctagctggg aaatagagcc
catcatactc aagagtggca ggagccaggt 7020cctggcccct gaagcttggc
ctcacacaca gaggccggca ccctgtcatc aattccctca 7080gctttttctc
cgcctccact cccagtccta gatttagcag ccatgtgtgg gtgggggcca
7140ctgcagggat acttacccac ctaccagaga gatggcctgt gggtgctggc
ccttctgagg 7200ctgtggaggt tggaggctgt ggcagcctgg gcagtcaggc
tgtggtcctc ccatgttctt 7260gactcctgct agtctgggct gcctcctgat
taggggttgg atgctccagt tcttccctgg 7320gttggggatt gccaccctac
tcccagccca tccaggttca cgcttattcc aaagcggagc 7380accagcagtg
tgcctgctgc gggagttctc cgtgtccagc ctgagggttg cctgccaacc
7440cctctgagag gtgcccggag gctgtgcgcc cacactgccc agcagtgcgg
agaagcaggc 7500ttgtttttcc ctgtcactgg cttggaagag atgctttgtt
ctagggagcc gcatgtcccc 7560ttgcctgcgt tgttggtgag gagccagcag
gctccgtgga gggcaggcta gcagcctggc 7620accagggagg caagggtctg
agttcctagg agggtggttg ctcatgtgag aagtctgcaa 7680aggttactac
tgagcaccat ctctctgtct gaaaaacatt tttcattttt ctgtgaacca
7740ctaagtttcc cgtttgggct ttcttcctgc ttttggctct tgtttaggca
ggcgtagcca 7800gatccaagcg tctggctgct tccccatgtc ttcagacctc
tttttctgtt catggtaact 7860atagatggaa ccacacattg gaagctggaa
actcaagcgg tgcagcctat tccttacccc 7920aatccctgtt ttacaaatgg
ggaaatcaag gcacagcatg gggtgatgct tatctgaggt 7980tggaagagtt
aatagtagag tgggagctaa aacccagttt cttacctcca agctcagggc
8040tttcagctgt aattgagcct agtatagttg gtgtgcagca tcagggattc
cagctctaaa 8100ggtcacaaaa aggacccggg ggtcattggc ccagggtggg
aacctgagca gagcaggtcc 8160agatggtgca ctctgtgccc tggccttagt
ttcttgctgg atgctttggc ccgtagagcc 8220ccagagccct gcttccagaa
ccactccagt gacgttcatg ccaatggcct gaaccccact 8280gagcgagggt
gccctgcctc ttccacagcc ctgggctccg ctcagatttt taggagcaag
8340cgttagaggc cttgctttct ccagggtcag catgtggaca gaacacttac
tctctgcctg 8400tctctcctcc tcaaaatgga agcaagacag tggggcctac
aatgctatga aaaacaggat 8460gggaaagaag cctgctctct gccttcctgc
ccaggtgagc catcacctga ctaagtgagt 8520tcacactcag agcgtgtggg
gatggcagga tgttctgact tcattttcca ggatgccttt 8580gctttaaaac
cttttaaaaa gaagtgaatg atacaccccc tttgctcatc ttgcagtgga
8640acctggtgtg tgaggacgac tggaaggccc cactcacaat ctccttgttc
ttcgtgggtg 8700tgctgttggg ctccttcatt tcagggcagc tgtcagacag
gtaaggtgtc tgtcttctgg 8760agcaccaggg gacctcagca ctgaggaaga
agcgtgtgcc tggcccttga tttcagttgg 8820tagtattctt tcagcgcagg
gccctgtatt ttaaagaaga ggaagctatg tctgtgatat 8880agactccatg
cctagtaaga agagccaaca aatcatctga ctccgtaatt cttgctaagt
8940aaagaaacct gagctgtcta agctgaatgt atctgtgatc cggttgacta
ggtaatatgc 9000catgattcac ttctgcagta gcctggcttg cctcccctgg
gtcactgtga ctctgtcatg 9060cccctgagca tgggagaggt tgacatcatg
cacacatgca catgtgctag attgtagatc 9120tgtagtagtg ccacggtgtc
tgcctctgta gtcccaagaa gaccagcatt ctctctgcaa 9180agtgaaagga
gctctcacca gccactagtg gtatgaaaag cagaactctt ttgtccacaa
9240ggctgatgcc ccttagctaa gtggcctgtg gttttggcat ttactttatg
acaggaggga 9300gaatagtgtt ttgatccatt tcttataagc aggttatttg
tataattcta aagcttttaa 9360ctcaaggaaa cattaacggc ttagagaatc
ccaaacccct cgaaattata tgcacaatgt 9420tagagactac atgtgagcat
ttttttggag agaggtccgt agctttcatg aagttcttag 9480aggggtccat
tatgttgtgt cttctttccc tggagcttca gggtctgtca gagaagactg
9540tgaagagagt agcagccttc agcaagtcct tggccacatg gcacatgtga
gaacacccca 9600caaatcggtg ggttagccgg tggaaaggag tcccagcatc
ttccctggtt tttaattcct 9660ggcctcaagc aatcctccct ccataacctc
ccaaagtgct gggattacag gcgtgagaca 9720ccatgcgcag ccagatattt
tttattgttg ttgttttttt ttggaaaagg agtttcactc 9780ttgttaccca
ggctggagtg caatggcacg atctcggctc actgcaacct ctgcctccca
9840ggttcaagag attctcctgt ctcagcctcc tgagttgctg ggattacagg
catgcaccac 9900catgcccagc taattttgta tttttaatag agacaaggtt
tctccatgtt ggtcaggctg 9960gtctcaaact cccgacctca ggtgatccac
ccacctcggc ctcccaaagt gctgggatta 10020caggcgcgag ccactgcacc
tgcccagcca gatttttttt taaaaagcag gttaacctgt 10080ttattattcc
tactttacag atggagaaag tgagacagag ggattaaata acttccccaa
10140ggtttcacag ctggcaagtg gcagagttag gatttggacc caggtagtct
tgctcctcta 10200ttgtgtatgg actactgttc taggtccctg ctgtcctaaa
acttgctttc tagcaaggtg 10260gaatgtatta aacaaccaag tgaggaagtc
gttgttgtcc ttggccatgg taagagatac 10320agagaagtgc agggtgccac
aggagtgtct aacagaggag gtcaggggca gcatccctga 10380gaaggtgaag
catgagcgag agtgggaaga tgagtcgaaa gtagccagct gaggggtaga
10440gaggagaaag aacatccagg cagggagaat agcaagtgct aaagccgggg
ctcatgaaaa 10500ggcatgggag caggacaaag tccgtgtggt agaggtgcgg
agagtggtgt taagatgaag 10560gggagaggca ggcagagccc tgggcagatg
agcaaccagg gcttagtgga tcacagttag 10620gactttgggc ttcagccaca
gagcagcggt gggctactga gattttttaa agcaatagtg 10680tgacaatcag
atttgtcctt tttttttttt taaagatgct ttgacaacct tgtgaagaaa
10740gaattgaagg gaagcaaaag gtgttgtaga gagaccaatt aaaaggttgt
cacagtagtt 10800catgccagag atgatggtgg catggcctag catgacggtg
gtagaaatgg agggaagtgg 10860taagaggtaa aatcaacaag acttgccgat
gggctggatg tcggaattgg gggaagaaag 10920ctttctggcc tgagtaactg
ggtgaatgaa ggtacacttc tctaagacag agaatgctgg 10980aaaagaacca
cgttcatgga tattgagttc aatttgtgtg tactaaattt ggggtgacta
11040tgagacccct aagtggagaa gtagagtgtg aagctggctg tatggatatg
gtactgcatg 11100agaggttttg gctagagaaa cacatgtagg atttgtcagc
atatagaacc ctcagcagag 11160ccccagatag ggatgaggtt gcctggggag
aggggagtgg ggaggggagg ggggaactgg 11220gggaggattg tgctatgctt
agaggccacc tgagtggaca tgggagattc cttctcacgg 11280agctaagtga
cagctgcggc tcagaagaat gcccttgatg tgaaaaggag ataccccaag
11340ttcagagtag aaatgcagtg tatttttctg ggtcagctgt gtcatgggtc
agcttaagaa 11400ccttcttgcc atgtgacaca atgattacct gaggaaagca
tttaagttcc aaaaggtcta 11460ttcccaggga aagtggaaac aaaatttgtg
agtgtgttta ggaccacttt agtctacaga 11520agggctaata tagtgttttt
caaacctttc taaacatttt
ggccacagaa ctttcattaa 11580agtaggataa tttaagtcta gtaaatgaaa
tacaccctaa gtggctaaaa gtatggctgt 11640tctgcctgca gcccctgcct
tcaattccca atgccctgcc tcaagcctgt ctgtgccccc 11700ttggaaggcc
cagggccctg tgggatggac agcttctgag tgcattactt ctgagtaaac
11760cagttctaaa acctaagcta agtagattac ctgaaagcaa tcaattcatg
ccctaacttg 11820tctaggacat caatgtaact ttttatatag tataaaggtt
tcaccttctt tctggcctat 11880gaatatgtct gaaattcaag agcaattaaa
gtactcctgg gttgtcaaag ccctttatgt 11940aacactattg agttatcttt
atgcgtctga cttgtaagag atgcacaact ctaggaagaa 12000gtagactgct
gtgtcctgtt tccaggtatg tgtgtgtttg ccattttgtt gacagacttt
12060aaaagcaaac atttctggcc ccaaccctga actgccaagg actggtgcta
tgtaaagggt 12120tctctggatc tgtctcttcc ctaccatccc agggagctct
taggaaggga aagggcatag 12180agattatacc agcctgcctt gtggttagga
accacccctt ggttggcata tagaacatgc 12240ttgttaaaaa aaccatgcag
gggaaagtag agtctactac caggcgagag tttctcaacc 12300tcgaccctat
taacattttg agccaaataa ttttgttcta gggcattttc ctgggcattt
12360tagaatattt aacaacatat ctggcctcta ctcattagat gccagtgaac
cccaagtgat 12420ggaaaaaaaa aacaacaaca gaaaaaaacc tcttttattg
aggaaaaaca ccaaactctt 12480ccacatagtt gcaagacctt gtgcaatttg
cctcctagcc accactgtac tcttgaattg 12540cacgcctgat gccaaccaca
ctggttcctc atgttcacca tgccccctcc agccatgggg 12600gtgtgtggtc
ttctcagagt ctgaagcatt ccccacccac cccaacccac cccctgtggc
12660cttctttaac catgctggct aattcaggat ccctagttcc ttatgacttt
cctttaaaac 12720gtctaccaga aattggggga aaaaaagtgt tattatagga
ttaatgttgg tcttccccac 12780tatactgtga atatcattga gagcttggtc
cctacacctt aaatccccca tcgtcaacta 12840ttttttccca tctcagtgtc
ccatgatcaa ggagaccctc cctgaatgtc cagttcccca 12900acccttaccc
ccagtccagg gtagcttcct tccttgtgcc tctcattaac ctgcatgccg
12960atccttcagt gcacttgact cagtgtgtaa ttgtatattc agtagcgtgt
tgttagatta 13020aaatgtggtt aatatgtgtt tcaccagtta tactatgaca
ctccttaagg gcagaaacag 13080catctttttt aatttattga tatccaagtg
ccctctataa tagatgctca ataaacattg 13140aatgaaagtg ggtgtcagcc
agtactggcc agactcaaac tgaacccact gcttcccact 13200agcttgactt
tttcctcctg tttgtggcac tctctttaaa acaaaccaaa ataaacccaa
13260ttttaaaaac tttttaaaat gagcacggat acagaaaacc acacagaaca
aatgtgtagc 13320ttaatgaatt tttttcagag aaataacctt atgaccacca
ccaagtcgag cagtagaact 13380ttgctgtcca ctaagaagcc ctgtccatgt
gccccatccc aattacagca tcctctctct 13440ctccccatta agtaaccgct
agcctgactc ctgtaataat cacttccttg tgagtttttt 13500tagttttatt
atcgaaatat gcatccttga cacaaattta gtgttgccca cttaatatat
13560ttgatgtctt ttagtctact taatctatgg attctccttc tatcgccttc
tatgccttac 13620tgattatcta tgaagaacct gagctattcc acctatagaa
tttcccagtc tggatttgtt 13680gattgcacac tgatgatgca gttcagcaca
ttcctctatg ctctgcattt cctcaaaatt 13740ggcagttgga tccagagact
tgagattcag gttctgattc aggttcagtc cttttggcaa 13800gaccatagga
agcatgcaat tcctgactgt ctctttatga tgttaacagt aattagtata
13860taatgcatag atctattaat ccattggggg ctataaatgg tattattcta
attttattac 13920cttttcattt aaaagttaga atacttttgt acatgatact
acctcttatc tattattggt 13980tgctgttcac atagtttaca aaggaaaatc
aggacaaatg cttctttctc tttatttgcc 14040agttttcatt tataatgaat
tgtttctctg ttattctcca aatttggcag attctttttt 14100aaaaaaaata
tcattatgaa tgtatggatt aaataattga tgtatttcag tctcttgcaa
14160tcattatcat aattgtagca ttgcttttta ggcaaccctg gtacccaggc
tgtacatttg 14220tcatggggag tggggagggg gagaaatagc atgggcactg
tgagaccgag actgtccctg 14280gcagccagta ttctggcaac actgttcaca
cccacttact ggatggatct tgagaaagcc 14340ccacttggtg gagcccattc
ctgctgccct tttccagctg gttatctgtc actctccttt 14400tcttcccagg
tttggccgga agaatgtgct gttcgtgacc atgggcatgc agacaggctt
14460cagcttcctg cagatcttct cgaagaattt tgagatgttt gtcgtgctgt
ttgtccttgt 14520aggcatgggc cagatctcca actatgtggc agcatttgtc
ctgggtatgg ccatcaggtt 14580ggagttgagt acttgatcct gtatttcacc
atcatcccat cacctacctt tctggagaca 14640gctgtgatgt ccctcaaggg
ggacagggtt tctaacaaaa ctagccagag cttcctggtg 14700aaccttactt
acaggcaggg aaactgagcc agacatgaga ccagcctggg gtccccagca
14760gcacaatggc ctgacttctg atttccagtt cttttctggc ctctgggctg
tggctccttg 14820gtcttagtac ttggtagtca atttactagg actcaccaga
gatcctccat ttacaaaaag 14880ggcctgccac tgcacagggc tgagccagcc
ccagaaagag ggcggcatgg ttggaggagg 14940aggggctgtg actggcaagc
ttgctaaggt agagaacccc ttgtctgcag agcactgtgg 15000ctggtgatat
ctacggacaa gaataaattg ataggaaggg gctttcgtca ccttcagggt
15060tttaattcag agtgcacact gcagggcttt gtctcaaatg tgccagcctg
ttgtcactga 15120gaagctgcca ggccggcctg tgtttggagg aacctgactc
tagctgataa ggcctttgag 15180ttccttgggt tgtattgttg aaagggttgt
tttttctttt tatatttaat attctttcct 15240tgaggcttaa gtcagcatgt
gctgacttag taatgacttc acttttaata aattcttcct 15300catgtgagga
ttaaaggggg cctaccatgg catctttagc acatggcttc agaacatggc
15360gaaattttca agagagaact gttgcttggg ggcctgagag gccacaggga
tgtaccccca 15420ggagacagtc agacaggagg ggttcagaac gccatccgct
ccctagcgcc atgaacttag 15480agagagttct cgctgttttc ttgtctgtgt
attcacaaag ataccataaa aaattaataa 15540ggaaggaacc caaattaaac
tgctaactcg acctcccttg ttttgaacag ggacagaaat 15600tcttggcaag
tcagttcgta taatattctc tacgttagga gtgtgcatat tttatgcatt
15660tggctacatg gtgctgccac tgtttgctta cttcatccga gactggcgga
tgctgctggt 15720ggcgctgacg atgccggggg tgctgtgcgt ggcactctgg
tggtgagtgt gaccctgtgc 15780cccatgtgcc cactggcagg atgatttctg
tctggccttc actagagggc agcaacaacc 15840catgaatccc tattttgtct
cccagagaca ggaagcatag attataaatt atttcagaat 15900gttttctcca
cactcaaaag agccaaaaca aaacagaatc ccatgacagc aacagacttg
15960ctctcagccc tgtgctgggt tgccccaagt gtggggaaaa atagcagtag
ctgtgagaag 16020atggggtcca gcatgccctg taggaagttc ccaagcctca
gggcaggaca gtgtaggccc 16080tagttctggc tgtgtgctgc tgaagcctca
tgccacaggc actggcacca aaagcaagag 16140tcctcagggt agccacatgg
aggaagccag gctccttctg caccaccaag gtagaggagt 16200tgaacaggca
gagaagaggc cattccagac caagagggga acactgcaga ggtgctaagg
16260tgggaatcac cccttgcagg tggagaaggt gagatcacca gcccaagtgg
agcagagagc 16320atttcagggc atagtgggag agtaagccgc acatcatggg
gcccagtcat gaccgagggt 16380ggggggcggc tacctggtcc cagcaaggtg
gaaaataata tccatagagc actcaagtgc 16440cttgataaac atgctaattt
ttttcctttt tttcttttct ttttcttttt ttttcttttt 16500tttttctcag
acaaagtctc tgttgcccag gctgtagtgc agtggcgtga tttccactta
16560ctgcaacctc cgcctcccca gttcaagcga ttctcatgtc tcagcctccc
gagtagctgg 16620gactacaggt gcctgccacc gcacttggct aatttttttt
gtatttcttt ggagagacgg 16680gtttcactgc gttggccagg ctggtctgga
actcctagcc tcaaatgatc caccggcctt 16740ggcctcctaa agtgctggga
ttataggagt gaaccactgc acctggccaa acatgctatt 16800ttaggtagag
tatctgacta atctgttgga taaatcaggg gtagggtgag gagagaagag
16860aagctaaaag gccagtgcag aagcttctgt tggtgccggg gacagggagg
agagtgtagc 16920agggcctggg ctgacataga catgcacaga agccaggctt
ccggagccca tcttgcaccc 16980atctcctcag cccagcagat ggcaacactg
ctcttcagaa atggaggtgg ccagccagca 17040tggggatgcc gtcagggggt
gcagggctct cccatttttg tgcggtgtgg ggtacacata 17100agctcatcca
ccccaggtta ttgctgcgtg tggatcagct ctttgcttct ggcttgtgat
17160caccaaacat tccacaagct ctggttctgc aaccttattc ccacctatgg
ctgtgctcta 17220cctggtctgt gggtctgctg ttggcaggga ggcctcactg
agattggacc ttgtactgcc 17280aggttcatcc ctgagtcccc ccgatggctc
atctctcagg gacgatttga agaggcagag 17340gtgatcatcc gcaaggctgc
caaagccaat gggattgttg tgccttccac tatctttgac 17400ccgagtgagg
taagcaccat gtgggtgtgg gtgagaggga cagactgacc gtgatttgag
17460agcagcagca cccagccctg aagtcctccc tgctcacagc agcccagccc
tctctctgcc 17520caagccccaa ctgcccattc cccccatccc cccactcccc
acccccacac gggccctgtt 17580aacactcaga agttgaggaa taggttacag
ctgcctcact cttttcacca cgggtttcag 17640attttcattt tttacttcct
ttctaggcaa tcatatattt taaccattac ttctaacaat 17700aaatactctt
tttgagtaat aggcctttca taaagtcagc atttgggaaa atcattgttt
17760cttataccta aggtggcttg tcaccttaca aagctaaccc caaacgtaaa
atgtaaagca 17820caaatagatt tggagttaga agtatttcat ctcttgagta
ttagcaatta ttcattaaaa 17880agaaaaaaaa agtgtttagt ctctttctgc
cctccaatgg ttaattattg catatcatct 17940tggagtcagg tcctttttga
tgtccacctc ttccccctac cccacccctc ccgtcagccc 18000tgttctcaca
caccatgact catttcttgg ctctacctag ttcctggttc ttgcttttcc
18060ttcccgttcc ctctcctacc atctctgtag caggcagttt tccttggtct
cgtgactatg 18120agaggttaga agctgtaaat gctgcctggt ggggttctgg
aatgtgtctg tggtctgact 18180ggaagatgag gggttgggtg tgggaacagc
cacaagcagc cctgctgaag tgtgagaggc 18240aggcatggtt gggcttggaa
aagagggaac agttattgta gacagcggag gccaatggcc 18300actgccagcc
ctgcagactt cccagtgagt ggtggcccag cagccactgt cagcatgcac
18360cagaaagggg tcctgtgcgc aaaggtcagg caggagtgtg gcagagggct
tttaagttag 18420gtggttttgg gggcttttaa gtgaggggtc aatctgggtg
aatgcataag ccccactggc 18480atctttgagg aaatgaggct atttcagggg
atactttcag tccaaagttg accttttgtt 18540gaacttctaa ctctggaaaa
acaagctcca aacctgggtt tgcttaagaa agcaacatca 18600gtgtgtttag
acgtgtggtt tattaatggc cttggctgtg ctgaatttca taggaagtca
18660ctctgggtga agctcaggtc aattttcctg tttttctatt tgaattcttt
ttccctggaa 18720gcacaccagt aactacatag tataaggact caaaacatta
acttttaaaa aatatcagac 18780caataaacca cacagccagg tactctctct
gacccagagg gcagggagcc aggcttcggg 18840aggaatactt agaggcctcc
ttggaatgtg gccaccgaca ggaatatgtg ggggtgcagt 18900gaggaagctg
tcagcctggg cctctgtctt cctgtaccct tgagggactg gtcacttact
18960tttcctcatt ttcattcact ctgatttgtt actgacaagg cctagggaag
ttttcacagc 19020ctaaaacaca gtcagtatac ttactgttct tagaaacgta
acactccccg acgctgagat 19080gcagacagct aagatgccag ggattcaagt
atgttattgt gtgctctgag tctctgacca 19140cctcttcttc ccatacactt
atgatgttgt tcctgcagtt acaagaccta agttccaaga 19200agcagcagtc
ccacaacatt ctggatctgc ttcgaacctg gaatatccgg atggtcacca
19260tcatgtccat aatgctgtgg tatgtaaaag agacctgcct gaggcttcca
gacaaagctt 19320cttgaagtgg ccattgggcc tcttgtttac agacatgcct
cagacaaaat tcaaagccta 19380tgtcatcaga gagtgaaaag gatatgtctt
gtgttagatg gaaaaaatgg gcatgtcaca 19440attcttaatg ggatggaacc
tcagaaaagg agaatgaaaa caattgtgga ggctgttgtg 19500ggaaatatgg
actctcgtgg ggaatctctc cagatcttaa gatgaatcct tgcccaattt
19560gggtcattta gttcccgtct cctacccagt taccgacagt ggctgaggag
gccaggtagg 19620gcttttaaga aggatctgag tgaagacacc atgtcctgta
ggctgcagag gctgccagtt 19680actttctgga aatgtggaag tgggatgtgc
tcctcctggg atgtccataa acggtcctgg 19740agtcagggct atagcctaga
tgtccttacc aggttcccac taatgaggca aagtatgtca 19800gaaagggatt
tgtgaattac cagggagagg aaacatgtcc aagtgcacat cgctagcttt
19860tgctcagcgg ccgaaccctg ggattctagg cgacttctgg agcctggtgg
gttagcggtg 19920agaagatggg cgaggagggc ggacttcatc tcagagtcct
tattactagt ctcatccagc 19980tttgaggcag tcagccactg tgcctactga
gggagtgcta tgagtcaccc gcttccaagg 20040aatggcccag gatccctcca
ggcagttcac cattccctga gttggcctca agacaggagc 20100agcatgtagc
ctgcaccaca gacatgcaag cctgtgatga gtcacccact tttgtgttca
20160cccaggctct cctccctgct ctggatttcc tggggactca tgcacatact
ctttttattg 20220taccagctgt gtgttccacc tgcagatgag tcaaaacagt
ctaatccata aaggtctggt 20280ttgtcaaaga gtgtgggtca tcaacagaga
gaatgcctac tggggatgcc caggtcaggg 20340gtactgcagg gcatcctgat
gagaggcagt gtggcccctc cattgggagc cacctctctg 20400ctccacaagt
accgcggggc tggtgtcagc tgtctctgac cagcctcttc ctgactggtc
20460accacaggta gtgtgtgagg gtctctctcc aagtgtttga cctaatgttg
ttccttttgt 20520tatcttatcc cccaaatcct atcacacctc acttgatgtc
tgcctcctga ctcattctct 20580agctccttct gcagttgctg gatttgagga
ggttcagctt aggattttta aagctgaaag 20640gcaggttgga atttttcttt
tcaatgaagt aaatctatct gaattataca agcttttttg 20700ctgggacact
gtctatatgg aaggctctga gagcgcactg gcgcagggtt tacactgtac
20760cacttgggct ggggaaaatt atcttttgat ctatgaagta agacgcaggg
ttacagttac 20820tgctgcctta ctagtctctg cttaaagatg gtttggaatt
tactgaaata attgcattgt 20880aaaagttgta caggttggga aagatgtgga
tactgctttt ccagctttct tctgcactct 20940gtttcaggat gaccatatca
gtgggctatt ttgggctttc gcttgatact cctaacttgc 21000atggggacat
ctttgtgaac tgcttccttt cagcgatggt tgaagtccca gcatatgtgt
21060tggcctggct gctgctgcaa tatttgcccc ggcgctattc catggccact
gccctcttcc 21120tgggtggcag tgtccttctc ttcatgcagc tggtaccccc
aggtagggac catgtgcatc 21180tatggtttgg ggtcttcact gagtctctta
ctgtctacca ggctgtctca attaataaag 21240agaataaaat caagcccatc
acagctccct tgcttatata cattcttggc ctaaaaatca 21300atagaaagtg
tcttctgaga ctagaacact tatggcctgg gctttgaggg agtgggaaaa
21360agcagccatt ggggctgttg gttaatttta ctctgtaccc aagttaatgt
gctcatactg 21420ttttccactg cagaagaaga gggaagaaat agctatccca
ttcctttttt tcctggccct 21480gtcttcttta tttattcaac aaatagctat
ggcatgccta ccatgggctg ggcactgtgc 21540tcggtgataa cgatacacaa
gaaaacaagc caggcagaac cccaggccct catggaacgt 21600acaccctaga
tgagaagaca gacaacaaac aagtaaataa aatgcttaat atagttcaga
21660ctgtgttacc ttctaggaat acaaatgaag gacaatgccg agttagttta
catagtcaca 21720gatagtgtcc ctgaacaggg ggcagttcag tagaaatgta
cataaagtga cagaaagccc 21780tgaaaaagtc taggagaaca ttttaggaag
aagaaatggc aaaggcagcg accctgagca 21840ggggatgagc ctggcatgtt
tgaggaggag ggagaagggg aggggccaga ccactgagag 21900ggcctcacag
acccttagca ggattttatt tctgaaacta tcttagtatc ccacagatgg
21960gtgggaggta gccatttcca ataatttata gaacagttca tgggccctca
tctctccctc 22020tccatcactg tgcccagaga cttcagtgta cctgtagatt
tgggagcctc tgatggtcac 22080ttttgggccc atcaggctga gaacactgca
cgggaacagc tccccatggg atgtggcagg 22140aggagcccag aactgatgta
gaggctcaca gctgagctca gagtgacctt caggtcacac 22200atagctctcc
catcagcaca gcacagagag attagaagat caactcgaga ttctgatggc
22260ctatgatttt tttgaggtct gagtgggagg aaagcatgaa atgagttaga
actgaattct 22320ccattcatct aaacatcatg agttaattcc atagtgcctg
cagtgtgagg ttctggggtg 22380acagttaatc cctgacagac atgtctttaa
tgacttatag actgggaagc aggttgattg 22440gactattaag gagcttactc
tggtggtctc caggttgagg aaagtgcatg tccttatagc 22500tgcaggtccc
agcctccttt cagcaatcaa tttggaggga aatcttggct atagcccctt
22560cccccacaat aggaagtgat agaaactgac tccccaaaaa atttgggaag
aaagtatgtt 22620tgttttgctc tcaatagctg catgccatgg gttggtacct
actcctaccc tctttccttt 22680gcttctccag acttgtatta tttggctaca
gtcctggtga tggtgggcaa gtttggagtc 22740acggctgcct tttccatggt
ctacgtgtac acagccgagc tgtatcccac agtggtgaga 22800aacatgggtg
tgggagtcag ctccacagca tcccgcctgg gcagcatcct gtctccctac
22860ttcgtttacc ttggtaagtc ccatgagcca agggcacact agagcaacgg
gatggaagta 22920ctaactggct tgaatgtgag ctggaggttg cgtgttaaca
ggaaaacaag ttcatacagt 22980acatgggctc catccagtac tggatctttg
gccgggaagg gttcttgtcc cagtgcactg 23040gccctcactt tcaaatggaa
aacaacctat agattaccta gaaattgatg agaatattag 23100agggtttgtt
tctgttttag ccatcccagg ccttccatca gagactacaa ttcctttatc
23160ctaagaacct acagagtggt ttagggagcc agtgtgctta gttggagaaa
tttcttggaa 23220tcagagttta aaaggaacat gaggggaaag atgtccatgc
aagaggtctg atgaacgtaa 23280aattattata acctagagca ctatagagtg
attttatctt gtgtgaagat ccaccccatg 23340ccattttatg tagcaggtct
ccagttttct cttctcagaa ttatgtcttc atagcacctg 23400tggtttccct
gcacatccct agccagtacc tctttaggga gggtggcacc cacctgagag
23460tactcagagt gctttgtgaa catgctatgt agatctcaaa gcaagcaaaa
gcaccctgcc 23520taatctgaag gcagatcaca tgggctggga cacatctgca
gaggtggaag agttatttcc 23580atccctggac aagtacctca ggttccttgg
aaacccaacc ttggtaaata agaataatca 23640gcatggccca gaaataggaa
taatcagcat ggcccagctc ttctcctgca accgcccctt 23700tgtactcctc
ccctgcatgg tggaacactg ctgggctctg ggcatgcctg tgccagctct
23760gggttctgaa acctgtctag atgccagatt ctaatctgac tgctcagact
gtgagagatg 23820tgagaccaag aaggaaagtg atccccttcc agagtcctgg
gagcataaag gggtagatga 23880gagaccaagt ctaactgcag ccctgggcct
gaggctccgt ctgctttgcc ataggtgcct 23940acgaccgctt cctgccctac
attctcatgg gaagtctgac catcctgaca gccatcctca 24000ccttgtttct
cccagagagc ttcggtaccc cactcccaga caccattgac cagatgctaa
24060gagtcaaagg gtaagaagac ctcctctgtc agtgttgatg cactgggtct
gggtctggcc 24120aggtctcagg agcccctcac aatagagcta ctcgcaaact
ccctctcaca gacaccatgg 24180actagtttag ccattaaagg gttgtaaatg
gcaaggtgct tacttatagc ccatcctctc 24240tggtctgttc ctgtgtggac
atgtcactat acacatctcc atggcagtag ccgcactgga 24300taactcagag
gctagaagaa acctttcaga atctgctgca ggattctctt cccagggaag
24360atatcctcag ttcttgtttg tttggagact gggaggcatc tttttaaaat
gtgttactga 24420catatttttg cttgttttta tagaatgaaa cacagaaaaa
ctccaagtca cacaaggatg 24480ttaaaagatg gtcaagaaag gcccacaatc
cttaaaagca cagccttcta acatcgcttc 24540cagtaaggga gaaactgaag
aggaaagact gtcttgccag aaatggccag cttgtgcaga 24600ctccgagtcc
ttcagtgaca aaggcctttg ctgtttgtcc tcttgacctg tgtctgactt
24660gctcctggat gggcacccac actcagaggc tacatatggc cctagagcac
caccttcctc 24720tagggacact ggggctacct acagacaact tcatctaagt
cctaactatt acaatgatgg 24780actcagcacc tccaaagcag ttaatttttc
actagaacca gtgagatctg gaggaatgtg 24840agaagcatat gctaaatgta
cattttaatt ttagactact tgaaaaggcc cctaataagg 24900ctagaggtct
aagtccccca cccctttccc cactcccctc tagtggtgaa ctttagagga
24960aaaggaagta attgcacaag gagtttgatt cttacctttt ctcagttaca
gaggacatta 25020actggatcat tgcttcccca gggcaggaga gcgcagagct
agggaaagtg aaaggtaatg 25080aagatggagc agaatgagca gatgcagatc
accagcaaag tgcactgatg tgtgagctct 25140taagaccact cagcatgacg
actgagtaga cttgtttaca tctgatcaaa gcactgggct 25200tgtccaggct
cataataaat gctccattga atctactatt cttgttttcc actgctgtgg
25260aaacctcctt gctactatag cgtcttatgt atggtttaaa ggaaatttat
caggtgagag 25320agatgagcaa cgttgtcttt tctctcaaag ctgtaatgtg
ggttttgttt tactgtttat 25380ttgtttgttg ttgtatcctt ttctccttgt
tatttgccct tcagaatgca cttgggaaag 25440gctggttcct tagcctcctg
gtttgtgtct tttttttttt ttttttaaac acagaatcac 25500tctggcaatt
gtctgcagct gccactggtg caaggcctta ccagccctag cctctagcac
25560ttctctaagt gccaaaaaca gtgtcattgt gtgtgttcct ttcttgatac
ttagtcatgg 25620gaggatatta caaaaaagaa atttaaattg tgttcatagt
ctttcagagt agctcacttt 25680agtcctgtaa ctttattggg tgatattttg
tgttcagtgt aattgtcttc tctttgctga 25740ttatgttacc atggtactcc
taaagcatat gcctcacctg gttaaaaaag aacaaacatg 25800tttttgtgaa
agctactgaa gtgccttggg aaatgagaaa gttttaataa gtaaaatgat
25860tttttaaata t 25871624DNAArtificial SequenceDescription of
Artificial SequenceArtificially Synthesized Primer Sequence
6gcaggaccaa ggcggcggtg tcag 24724DNAArtificial SequenceDescription
of Artificial SequenceArtificially Synthesized Primer Sequence
7agactagagg aaaaacggga tagc 24824DNAArtificial SequenceDescription
of Artificial SequenceArtificially Synthesized Primer Sequence
8agatttttag gagcaagcgt taga 24924DNAArtificial SequenceDescription
of Artificial SequenceArtificially Synthesized Primer Sequence
9gaggcagaca ccgtggcact acta 241024DNAArtificial SequenceDescription
of Artificial SequenceArtificially Synthesized Primer Sequence
10ttcacaccca cttactggat ggat 241124DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 11attctgtttt gttttggctc tttt 241224DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 12agcagggcct gggctgacat agac 241324DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 13aaaggacctg actccaagat gata 241424DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 14tctgaccacc tcttcttccc atac 241524DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 15gcctcctcag ccactgtcgg taac 241624DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 16atgttgttcc ttttgttatc ttat 241724DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 17cttgttttct tgtgtatcgt tatc 241824DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 18tatgtttgtt ttgctctcaa tagc 241924DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 19tctgtgagag ggagtttgcg agta 242024DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 20tacgaccgct tcctgcccta catt 242124DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 21tcattctgct ccatcttcat tacc 242233DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 22gataagctta cggtgtcccc ttattcccat acg
332324DNAArtificial SequenceDescription of Artificial
SequenceArtificially Synthesized Primer Sequence 23cccatgccaa
caaggacaaa aagc 242424DNAArtificial SequenceDescription of
Artificial SequenceArtificially Synthesized Primer Sequence
24tgtttttcgt gggtgtgctg atgg 242524DNAArtificial
SequenceDescription of Artificial SequenceArtificially Synthesized
Primer Sequence 25acagaacaga aaagccctca gtca 242610PRTHomo sapiens
26Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu1 5 102717DNAMus musculus
27tcctgtggct gaccata 172817DNAMus musculus 28tcctgtggcg gaccata
172922DNAHomo sapiens 29agggcggcat gccgggacta cg 223019DNAHomo
sapiens 30cttgcagtga aacctggtg 193119DNAHomo sapiens 31tttgccataa
gtgcctacg 19
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