U.S. patent application number 13/208709 was filed with the patent office on 2012-03-22 for nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines. This patent application is currently assigned to OTTAWA HEALTH RESEARCH INSTITUTE. Invention is credited to STEVEN GRIFFITHS, JOEL HEPPELL, RACHAEL JAME RITCHIE.
Application Number | 20120071630 13/208709 |
Document ID | / |
Family ID | 27255591 |
Filed Date | 2012-03-22 |
United States Patent Application | 20120071630 |
Kind Code | A1 |
GRIFFITHS; STEVEN ; et al. | March 22, 2012 |
The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.
Inventors: | GRIFFITHS; STEVEN; (MONKTON, CA) ; RITCHIE; RACHAEL JAME; (FREDERICTON, CA) ; HEPPELL; JOEL; (CHELSEA, CA) |
Assignee: | OTTAWA HEALTH RESEARCH
INSTITUTE OTTAWA CA NOVARTIS AG BASEL CH |
Family ID: | 27255591 |
Appl. No.: | 13/208709 |
Filed: | August 12, 2011 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
12624918 | Nov 24, 2009 | 7998484 | ||
13208709 | ||||
11525695 | Sep 22, 2006 | |||
12624918 | ||||
10734782 | Apr 2, 2004 | 7128917 | ||
11525695 | ||||
10049086 | May 30, 2002 | 6919083 | ||
PCT/GB00/02976 | Aug 7, 2000 | |||
10734782 | ||||
Current U.S. Class: | 530/350 |
Current CPC Class: | A61P 31/12 20180101; C12N 2760/16022 20130101; C07K 14/005 20130101; A61K 39/00 20130101; A61K 2039/53 20130101; C12N 2760/16034 20130101 |
Class at Publication: | 530/350 |
International Class: | C07K 14/155 20060101 C07K014/155 |
Date | Code | Application Number |
---|---|---|
Aug 7, 1999 | GB | 9918588.6 |
Mar 11, 2000 | GB | 0005848.7 |
Mar 21, 2000 | GB | 0006674.6 |
Sequence CWU 1
1
1011821DNAInfectious Salmon Anaemia Virus 1caagatggat aacctccgtg
aatgcataaa ccgcaaaaga agactacttg ccttaccaga 60tgttcctgaa acttcggatg
cctttctaag tgatttgaga catctataca tgtgtgttgc 120tttctgtgat
caacacaaaa ccactggaga cgaatcaaga ttcaccaacc tggaattact
180tgaccaagat gaagcactag gtgcccaaag agcttttgaa gccaaacatg
gaataaaagg 240aggttcttta ggagacgttc ttgaccatga actgaaaaag
gtcattgaat ttacttttac 300ttctggaagt ttgtatattg ccgaacaaag
aaaaagaaag actcaagcag actcaataat 360tgtgtgcgtt tcagaaggac
ttaacgactt cagcgtatca cacggagtgc tagacatggg 420acttgtggaa
acaggggtga atgcagtaag agatttctgc acacaaaacg gaataccaat
480gaagataaat caggtaggat ccacgagaac accaacaccg atcagcacat
gcaaaatctc 540tgaacaaata acacgacaga taaacagtac aattactgaa
aggaaaatgg aaacagtact 600ggcagcaatc gcaattaaac cagaactcaa
actaactcag aaaggatgca gaccttgtaa 660agaactagaa gatgaaaata
ttctgtggat ggaccctcaa ttctgtgaaa ttgatgaaag 720ttttccttac
agaggagggc catacgggaa cttcctgcaa gaattgctgc ttacaaccaa
780cgacgtagag accaacggga aagacagaga agaagtagta aagaagatac
tggataacaa 840ggcgttcacc gttgaaagtg gtgaatgcat aataacactt
ccagacaaaa tgacttgttt 900cggagaacag gagaagaaga gaccagcaac
aatagacgaa gtgagaaccg caggagaaag 960gtttgaacag agtgttaaac
cgaaaaccca aagatatgga aggttatcag acaaatggat 1020ggagcttgaa
aagtttatct ttactgcaag caaaacagaa gtggatactt tcctttctgt
1080agggaccgaa agacttgagt cggttggagt gtgtgtcgga gctttacaca
gagcgaccac 1140aaccaggata attagaccta tgattcaagg agggaaatgt
tgggggatga tgttcaaaac 1200aaagtccaaa atgggagaca cgaggaagga
aggatactgt cacgcaatca ttttcggaaa 1260aggggaagat aaatcaggac
aaaacaagat gacaatgatg gggaaaacag tacattggca 1320tctaagagta
gttaagtcta aaggagactg gatggcgcaa caactctgtg caaacaaaag
1380cagaatatgg gaacatgacc ctgagctagt aacagaagga gtgacagttc
taatgacgcc 1440tttttctcag aaaattgcca ccattagtag atggagggca
atgaggttag acagcatgtt 1500tcatgtttct agtgcctggc atcattcacc
tgcgtgtgaa gctgcatcgg caatgctgag 1560aaagtttgtg gagatagtac
atgccatcaa ccagaaaaga gattggggtg ttgtggggag 1620tatggaggac
atggtgaagg aagtggagga aataggggag cacttgcaga cggcatgtga
1680ttttagagtt tacaacatgt gcaaagcctt gattcagaaa attgcagtca
gtacccaatg 1740agtggttatt tacttgtaaa ttgttgtgtg tttgacgata
tgtatttgtc gacgcggccg 1800cggtcgacgc ggccgcgaat t
18212578PRTInfectious Salmon Anaemia Virus 2Met Asp Asn Leu Arg Glu
Cys Ile Asn Arg Lys Arg Arg Leu Leu Ala1 5 10 15Leu Pro Asp Val Pro
Glu Thr Ser Asp Ala Phe Leu Ser Asp Leu Arg 20 25 30His Leu Tyr Met
Cys Val Ala Phe Cys Asp Gln His Lys Thr Thr Gly 35 40 45Asp Glu Ser
Arg Phe Thr Asn Leu Glu Leu Leu Asp Gln Asp Glu Ala 50 55 60Leu Gly
Ala Gln Arg Ala Phe Glu Ala Lys His Gly Ile Lys Gly Gly65 70 75
80Ser Leu Gly Asp Val Leu Asp His Glu Leu Lys Lys Val Ile Glu Phe
85 90 95Thr Phe Thr Ser Gly Ser Leu Tyr Ile Ala Glu Gln Arg Lys Arg
Lys 100 105 110Thr Gln Ala Asp Ser Ile Ile Val Cys Val Ser Glu Gly
Leu Asn Asp 115 120 125Phe Ser Val Ser His Gly Val Leu Asp Met Gly
Leu Val Glu Thr Gly 130 135 140Val Asn Ala Val Arg Asp Phe Cys Thr
Gln Asn Gly Ile Pro Met Lys145 150 155 160Ile Asn Gln Val Gly Ser
Thr Arg Thr Pro Thr Pro Ile Ser Thr Cys 165 170 175Lys Ile Ser Glu
Gln Ile Thr Arg Gln Ile Asn Ser Thr Ile Thr Glu 180 185 190Arg Lys
Met Glu Thr Val Leu Ala Ala Ile Ala Ile Lys Pro Glu Leu 195 200
205Lys Leu Thr Gln Lys Gly Cys Arg Pro Cys Lys Glu Leu Glu Asp Glu
210 215 220Asn Ile Leu Trp Met Asp Pro Gln Phe Cys Glu Ile Asp Glu
Ser Phe225 230 235 240Pro Tyr Arg Gly Gly Pro Tyr Gly Asn Phe Leu
Gln Glu Leu Leu Leu 245 250 255Thr Thr Asn Asp Val Glu Thr Asn Gly
Lys Asp Arg Glu Glu Val Val 260 265 270Lys Lys Ile Leu Asp Asn Lys
Ala Phe Thr Val Glu Ser Gly Glu Cys 275 280 285Ile Ile Thr Leu Pro
Asp Lys Met Thr Cys Phe Gly Glu Gln Glu Lys 290 295 300Lys Arg Pro
Ala Thr Ile Asp Glu Val Arg Thr Ala Gly Glu Arg Phe305 310 315
320Glu Gln Ser Val Lys Pro Lys Thr Gln Arg Tyr Gly Arg Leu Ser Asp
325 330 335Lys Trp Met Glu Leu Glu Lys Phe Ile Phe Thr Ala Ser Lys
Thr Glu 340 345 350Val Asp Thr Phe Leu Ser Val Gly Thr Glu Arg Leu
Glu Ser Val Gly 355 360 365Val Cys Val Gly Ala Leu His Arg Ala Thr
Thr Thr Arg Ile Ile Arg 370 375 380Pro Met Ile Gln Gly Gly Lys Cys
Trp Gly Met Met Phe Lys Thr Lys385 390 395 400Ser Lys Met Gly Asp
Thr Arg Lys Glu Gly Tyr Cys His Ala Ile Ile 405 410 415Phe Gly Lys
Gly Glu Asp Lys Ser Gly Gln Asn Lys Met Thr Met Met 420 425 430Gly
Lys Thr Val His Trp His Leu Arg Val Val Lys Ser Lys Gly Asp 435 440
445Trp Met Ala Gln Gln Leu Cys Ala Asn Lys Ser Arg Ile Trp Glu His
450 455 460Asp Pro Glu Leu Val Thr Glu Gly Val Thr Val Leu Met Thr
Pro Phe465 470 475 480Ser Gln Lys Ile Ala Thr Ile Ser Arg Trp Arg
Ala Met Arg Leu Asp 485 490 495Ser Met Phe His Val Ser Ser Ala Trp
His His Ser Pro Ala Cys Glu 500 505 510Ala Ala Ser Ala Met Leu Arg
Lys Phe Val Glu Ile Val His Ala Ile 515 520 525Asn Gln Lys Arg Asp
Trp Gly Val Val Gly Ser Met Glu Asp Met Val 530 535 540Lys Glu Val
Glu Glu Ile Gly Glu His Leu Gln Thr Ala Cys Asp Phe545 550 555
560Arg Val Tyr Asn Met Cys Lys Ala Leu Ile Gln Lys Ile Ala Val Ser
565 570 575Thr Gln32018DNAInfectious Salmon Anaemia Virus
3gcaaagatyg ctcaaatccc aaaaataata cagaaaacgt ataagagatg gccgataaag
60gtatgactta ttcttttgat gtcagagaca acaccttggt tgtaagaaga tctaccgcta
120ctaaaagtgg cattaagatc tcctacagag aggatcgagg aacatcactt
ctccaaaagg 180cattcgccgg gacagaagat gaattctggg tggagttaga
tcaagatgtc tacgttgaca 240aaaagattag aaaattcctg gaagaagaga
aaatgaagga catgagcaca agagtgtctg 300gagcagtggc agcagcaatt
gaaagatcag ttgaatttga caatttctca aaagaagcag 360cagctaacat
tgaaatggct ggtgtagatg atgaagaagc tggaggaagt ggtctggtag
420acaacagaag gaagaacaaa ggggtctcaa acatggccta caatctgtct
ctattcatag 480ggatggtgtt tcctgctctc actactttct tcagtgctat
cctatcagaa ggtgaaatga 540gcatctggca aaatggacaa gcaatcatca
gaattctggc actggcagat gaagacggaa 600agagacaaac aagaacagga
ggacagaggg tggacatggc tgatgtaacc aagctgaacg 660tagtcacggc
taacgggaaa gtcaagcaag ttgaagtaaa cttgaacgat ctcaaagcag
720cattcaggca gagtagacct aaaagatcgg actacagaaa agggcaaggt
tccaaggcta 780cagaatcaag catctccaac caatgtatgg cactgattat
gaaatctgtg ctgtcagcag 840accaactttt tgctccggga gtgaagatga
tgaggacgaa cggtttcaat gcgtcgtaca 900caacactggc agaaggggca
aacattccga gcaagtacct aagacacatg aggaactgcg 960gaggagtagc
tctggacctg atgggaatga agaggatcaa aaactcacct gaaggagcca
1020agtctaagat cttttccatc atccagaaga aagtaagagg aagatgtcgc
acagaggagc 1080aacgcctcct gactagcgca ctgaaaatca gcgacggtga
aaacaagttc cagagaatca 1140tggacactct atgtacaagc ttcctgattg
accctccaag aactaccaaa tgcttcattc 1200cacctatttc cagtctcatg
atgtacatcc aagaaggcaa ctctgtactg gcaatggatt 1260tcatgaaaaa
cggagaggac gcctgcaaga tctgcagaga agccaaactg aaagtggggg
1320taaacagtac gttcacaatg tcagtagcta gaacatgcgt tgcagtgtca
atggttgcaa 1380cagctttttg ttctgcagat atcatcgaga atgcagtgcc
tggttccgaa aggtacagat 1440ccaacatcaa ggctaacaca accaaaccaa
aaaaggactc cacttacaca attcaaggac 1500ttagattgtc taacgtgagg
tatgaagcaa gacctgaaac atcacaaagc aacacagaca 1560gaagttggca
agtgaacgtg actgacagct tcggaggact tgctgtgttc aaccaagggg
1620caattagaga aatgctagga gacggaacat cagagacaac tagtgtgaac
gtcagagccc 1680tggtgaagag aattctgaaa tcagcttcag agaggagtgc
aagagctgta aagacattta 1740tggtgggaga acaagggaaa tcagctattg
ttatctctgg tgtgggactg ttctctattg 1800actttgaagg ggtagaggaa
gcggaaagga taactgacat gacacctgaa attgagtttg 1860acgaggacga
cgaggaagag gaagacattg acatttagag tgacaattat gtaactttct
1920aattacccta tattgtttga atatataatg aaactattgt gtgttaaagg
ttgtgggttt 1980gattattaaa tttaaattga aacggtattg acgatatt
20184616PRTInfectious Salmon Anaemia Virus 4Met Ala Asp Lys Gly Met
Thr Tyr Ser Phe Asp Val Arg Asp Asn Thr1 5 10 15Leu Val Val Arg Arg
Ser Thr Ala Thr Lys Ser Gly Ile Lys Ile Ser 20 25 30Tyr Arg Glu Asp
Arg Gly Thr Ser Leu Leu Gln Lys Ala Phe Ala Gly 35 40 45Thr Glu Asp
Glu Phe Trp Val Glu Leu Asp Gln Asp Val Tyr Val Asp 50 55 60Lys Lys
Ile Arg Lys Phe Leu Glu Glu Glu Lys Met Lys Asp Met Ser65 70 75
80Thr Arg Val Ser Gly Ala Val Ala Ala Ala Ile Glu Arg Ser Val Glu
85 90 95Phe Asp Asn Phe Ser Lys Glu Ala Ala Ala Asn Ile Glu Met Ala
Gly 100 105 110Val Asp Asp Glu Glu Ala Gly Gly Ser Gly Leu Val Asp
Asn Arg Arg 115 120 125Lys Asn Lys Gly Val Ser Asn Met Ala Tyr Asn
Leu Ser Leu Phe Ile 130 135 140Gly Met Val Phe Pro Ala Leu Thr Thr
Phe Phe Ser Ala Ile Leu Ser145 150 155 160Glu Gly Glu Met Ser Ile
Trp Gln Asn Gly Gln Ala Ile Ile Arg Ile 165 170 175Leu Ala Leu Ala
Asp Glu Asp Gly Lys Arg Gln Thr Arg Thr Gly Gly 180 185 190Gln Arg
Val Asp Met Ala Asp Val Thr Lys Leu Asn Val Val Thr Ala 195 200
205Asn Gly Lys Val Lys Gln Val Glu Val Asn Leu Asn Asp Leu Lys Ala
210 215 220Ala Phe Arg Gln Ser Arg Pro Lys Arg Ser Asp Tyr Arg Lys
Gly Gln225 230 235 240Gly Ser Lys Ala Thr Glu Ser Ser Ile Ser Asn
Gln Cys Met Ala Leu 245 250 255Ile Met Lys Ser Val Leu Ser Ala Asp
Gln Leu Phe Ala Pro Gly Val 260 265 270Lys Met Met Arg Thr Asn Gly
Phe Asn Ala Ser Tyr Thr Thr Leu Ala 275 280 285Glu Gly Ala Asn Ile
Pro Ser Lys Tyr Leu Arg His Met Arg Asn Cys 290 295 300Gly Gly Val
Ala Leu Asp Leu Met Gly Met Lys Arg Ile Lys Asn Ser305 310 315
320Pro Glu Gly Ala Lys Ser Lys Ile Phe Ser Ile Ile Gln Lys Lys Val
325 330 335Arg Gly Arg Cys Arg Thr Glu Glu Gln Arg Leu Leu Thr Ser
Ala Leu 340 345 350Lys Ile Ser Asp Gly Glu Asn Lys Phe Gln Arg Ile
Met Asp Thr Leu 355 360 365Cys Thr Ser Phe Leu Ile Asp Pro Pro Arg
Thr Thr Lys Cys Phe Ile 370 375 380Pro Pro Ile Ser Ser Leu Met Met
Tyr Ile Gln Glu Gly Asn Ser Val385 390 395 400Leu Ala Met Asp Phe
Met Lys Asn Gly Glu Asp Ala Cys Lys Ile Cys 405 410 415Arg Glu Ala
Lys Leu Lys Val Gly Val Asn Ser Thr Phe Thr Met Ser 420 425 430Val
Ala Arg Thr Cys Val Ala Val Ser Met Val Ala Thr Ala Phe Cys 435 440
445Ser Ala Asp Ile Ile Glu Asn Ala Val Pro Gly Ser Glu Arg Tyr Arg
450 455 460Ser Asn Ile Lys Ala Asn Thr Thr Lys Pro Lys Lys Asp Ser
Thr Tyr465 470 475 480Thr Ile Gln Gly Leu Arg Leu Ser Asn Val Arg
Tyr Glu Ala Arg Pro 485 490 495Glu Thr Ser Gln Ser Asn Thr Asp Arg
Ser Trp Gln Val Asn Val Thr 500 505 510Asp Ser Phe Gly Gly Leu Ala
Val Phe Asn Gln Gly Ala Ile Arg Glu 515 520 525Met Leu Gly Asp Gly
Thr Ser Glu Thr Thr Ser Val Asn Val Arg Ala 530 535 540Leu Val Lys
Arg Ile Leu Lys Ser Ala Ser Glu Arg Ser Ala Arg Ala545 550 555
560Val Lys Thr Phe Met Val Gly Glu Gln Gly Lys Ser Ala Ile Val Ile
565 570 575Ser Gly Val Gly Leu Phe Ser Ile Asp Phe Glu Gly Val Glu
Glu Ala 580 585 590Glu Arg Ile Thr Asp Met Thr Pro Glu Ile Glu Phe
Asp Glu Asp Asp 595 600 605Glu Glu Glu Glu Asp Ile Asp Ile 610
61551050DNAInfectious Salmon Anaemia Virus 5atgtctggat ttaacctcga
ggtaatggtg ccggaacaag gaggaaaagt ggtcttcagc 60cttactgaaa cggggtcatg
tgtctcgttt tacggagatg atgaaccagg tgaagggtcc 120tgcgaacttg
cctctgaaaa catggatttt ccaagttgtc ctctggggaa tggagatgac
180ttctgtctgt cgctggcgct aagcacaatg agatggtctg ggatgaccaa
gagaaacaac 240ttcatggaca gattcattgg aagttttgtt cactgtacac
cagtgatgat ctggtcgtat 300ggaaatttgt ccaagaaaag ccatcacaaa
atggtttgcc acacttgccc agacgagtac 360aagttcagtg acaaggacga
gatgcaggga tactatgagg gatgtctaga ggcttctact 420gacattttcc
ttgatgaact tgctactgtt gttacaggtg gcttctttcc tgtcggactc
480aaaggttcct ggggaggatg gtacctcaag tacgtcaggt atgctggacc
tcttgcggga 540tcaagtggat tcattgtcaa tcaacgattc tacgacagag
cccaaaacaa gactggatcc 600agggttgtat ccatggttga aatggacgga
gacggcttat cgttcatcta cgagaagcct 660agcgtctacc atagtgatgg
gtgcactggg tcagcagcga ggttctggaa acgggatcac 720aatgagagag
ctggagttga gcttagggct ggacttcact tcagaatgtg attggttgaa
780aacttgttat gtaaacaaga attttgtgtt tttgtcagaa aaagaaattg
ctgtaaacat 840ggaagttgaa aaattcattt gtaatgagaa ctaaagatgt
ctttgtgttc aaattttaac 900taatgacaat atatgaaata tgtcgtacat
ggtgttgatg ataattttta aaacgaaaag 960gagaattttt actaaaataa
aaaaaaaata aaaaaaaaaa aaaagaaaaa aaaaaaaaaa 1020aaaaaaagtc
gacatcgata cgcgtggtca 10506256PRTInfectious Salmon Anaemia Virus
6Met Ser Gly Phe Asn Leu Glu Val Met Val Pro Glu Gln Gly Gly Lys1 5
10 15Val Val Phe Ser Leu Thr Glu Thr Gly Ser Cys Val Ser Phe Tyr
Gly 20 25 30Asp Asp Glu Pro Gly Glu Gly Ser Cys Glu Leu Ala Ser Glu
Asn Met 35 40 45Asp Phe Pro Ser Cys Pro Leu Gly Asn Gly Asp Asp Phe
Cys Leu Ser 50 55 60Leu Ala Leu Ser Thr Met Arg Trp Ser Gly Met Thr
Lys Arg Asn Asn65 70 75 80Phe Met Asp Arg Phe Ile Gly Ser Phe Val
His Cys Thr Pro Val Met 85 90 95Ile Trp Ser Tyr Gly Asn Leu Ser Lys
Lys Ser His His Lys Met Val 100 105 110Cys His Thr Cys Pro Asp Glu
Tyr Lys Phe Ser Asp Lys Asp Glu Met 115 120 125Gln Gly Tyr Tyr Glu
Gly Cys Leu Glu Ala Ser Thr Asp Ile Phe Leu 130 135 140Asp Glu Leu
Ala Thr Val Val Thr Gly Gly Phe Phe Pro Val Gly Leu145 150 155
160Lys Gly Ser Trp Gly Gly Trp Tyr Leu Lys Tyr Val Arg Tyr Ala Gly
165 170 175Pro Leu Ala Gly Ser Ser Gly Phe Ile Val Asn Gln Arg Phe
Tyr Asp 180 185 190Arg Ala Gln Asn Lys Thr Gly Ser Arg Val Val Ser
Met Val Glu Met 195 200 205Asp Gly Asp Gly Leu Ser Phe Ile Tyr Glu
Lys Pro Ser Val Tyr His 210 215 220Ser Asp Gly Cys Thr Gly Ser Ala
Ala Arg Phe Trp Lys Arg Asp His225 230 235 240Asn Glu Arg Ala Gly
Val Glu Leu Arg Ala Gly Leu His Phe Arg Met 245 250
2557140PRTInfectious Salmon Anaemia Virus 7Met Ser Gly Phe Asn Leu
Glu Val Met Val Pro Glu Gln Gly Gly Lys1 5 10 15Val Val Phe Ser Leu
Thr Glu Thr Gly Ser Cys Val Ser Phe Tyr Gly 20 25 30Asp Asp Glu Pro
Gly Gly Phe Phe Pro Val Gly Leu Lys Gly Ser Trp 35 40 45Gly Gly Ser
Tyr Leu Lys Tyr Val Arg Tyr Ala Gly Pro Leu Ala Gly 50 55 60Ser Ser
Gly Phe Ile Val Asn Gln Arg Phe Tyr Asp Arg Ala Gln Asn65 70 75
80Lys Thr Gly Ser Arg Val Val Ser Met Val Glu Met Asp Gly Asp Gly
85 90 95Leu Ser Phe Ile Tyr Glu Lys Pro Ser Val Tyr His Ser Asp Gly
Cys 100 105 110Thr Gly Ser Ala Ala Arg Phe Trp Lys Arg Asp His Asn
Glu Arg Ala 115 120 125Gly Val Glu Leu Arg Ala Gly Leu His Phe Arg
Met 130 135 1408146PRTInfectious Salmon Anaemia Virus 8Met Asn Leu
Leu Leu Leu Leu Gln Val Ala Ser Phe Leu Ser Asp Ser1 5 10 15Lys Val
Pro Gly Glu Asp
Gly Thr Ser Ser Thr Ser Gly Met Leu Asp 20 25 30Leu Leu Arg Asp Gln
Val Asp Ser Leu Ser Ile Asn Asp Ser Thr Thr 35 40 45Glu Pro Lys Thr
Arg Leu Asp Pro Gly Leu Tyr Pro Trp Leu Lys Trp 50 55 60Thr Glu Thr
Ala Tyr Arg Ser Ser Thr Arg Ser Leu Ala Ser Thr Ile65 70 75 80Val
Met Gly Ala Leu Gly Gln Gln Arg Gly Ser Gly Asn Gly Ile Thr 85 90
95Met Arg Glu Leu Glu Leu Ser Leu Gly Leu Asp Phe Thr Ser Glu Cys
100 105 110Asp Trp Leu Lys Thr Cys Tyr Val Asn Lys Asn Phe Val Phe
Leu Ser 115 120 125Glu Lys Glu Ile Ala Val Asn Met Glu Val Glu Lys
Phe Ile Cys Asn 130 135 140Glu Asn14591033DNAInfectious Salmon
Anaemia Virus 9cagtcgtcta tgtcttagaa accatcctga caccacctgg
ataggtgact cccgaagcga 60tcaatcaagg gtgaaccaac agtctcttga tctggttaca
aacttcaagg gaattctaca 120agccaagaac gggaatggtc tcatgaagca
gatgagcgga aggttcccaa gtgattggta 180ccaacctact acaaagtata
ggattctata cattggtaca aacgactgca ctgagggccc 240taacgacgtg
atcataccga cgtcaatgac actagacaat gtggcaaggg acctgtacct
300gggagcatgt cgaggagatg taagagtgac accaaccttc gtgggagcag
ctgagcttgg 360actgattggg agaacagatg ccttaacagg attttctgta
aaggtgctga ctttcaacaa 420ccctactatt gtagtagttg gactaaatgg
aatgtcagga atctacaagg tctgcattgc 480tgcctcttct ggaaacgtag
gcggagtcaa cttggtgaac ggatgcggat acttcagcgc 540tcctctgaga
ttcgacaact tcaaaggaca gatctacgtg tcagacacct ttgaagtcag
600aggaacaaag aacaaatgtg tcatacttag atcttctagc aatgctcctt
tgtgtacaca 660tatcaaaaga aacattgagt tggatgagta cgttgacaca
ccaaacactg ggggcgtata 720tccttctgat gggtttgatt ctcttcacgg
ctctgcttcg attagaactt ttttaacaga 780ggcactgaca tgtccaggtg
tagattggga cagaattgat gcagcttcat gcgagtatga 840cagttgtcct
aaacttgtga aagaatttga ccaaacaggg ctcggaaaca cagatactca
900aataatgaga gagctagaag cacaaaagga gatgattggt aaacttggca
gaaacattac 960agacgtaaac aacagagtag atgctattcc accacagctt
agcaacatct tcatctctat 1020gggagtggca ggt 103310344PRTInfectious
Salmon Anaemia Virus 10Ser Arg Leu Cys Leu Arg Asn His Pro Asp Thr
Thr Trp Ile Gly Asp1 5 10 15Ser Arg Ser Asp Gln Ser Arg Val Asn Gln
Gln Ser Leu Asp Leu Val 20 25 30Thr Asn Phe Lys Gly Ile Leu Gln Ala
Lys Asn Gly Asn Gly Leu Met 35 40 45Lys Gln Met Ser Gly Arg Phe Pro
Ser Asp Trp Tyr Gln Pro Thr Thr 50 55 60Lys Tyr Arg Ile Leu Tyr Ile
Gly Thr Asn Asp Cys Thr Glu Gly Pro65 70 75 80Asn Asp Val Ile Ile
Pro Thr Ser Met Thr Leu Asp Asn Val Ala Arg 85 90 95Asp Leu Tyr Leu
Gly Ala Cys Arg Gly Asp Val Arg Val Thr Pro Thr 100 105 110Phe Val
Gly Ala Ala Glu Leu Gly Leu Ile Gly Arg Thr Asp Ala Leu 115 120
125Thr Gly Phe Ser Val Lys Val Leu Thr Phe Asn Asn Pro Thr Ile Val
130 135 140Val Val Gly Leu Asn Gly Met Ser Gly Ile Tyr Lys Val Cys
Ile Ala145 150 155 160Ala Ser Ser Gly Asn Val Gly Gly Val Asn Leu
Val Asn Gly Cys Gly 165 170 175Tyr Phe Ser Ala Pro Leu Arg Phe Asp
Asn Phe Lys Gly Gln Ile Tyr 180 185 190Val Ser Asp Thr Phe Glu Val
Arg Gly Thr Lys Asn Lys Cys Val Ile 195 200 205Leu Arg Ser Ser Ser
Asn Ala Pro Leu Cys Thr His Ile Lys Arg Asn 210 215 220Ile Glu Leu
Asp Glu Tyr Val Asp Thr Pro Asn Thr Gly Gly Val Tyr225 230 235
240Pro Ser Asp Gly Phe Asp Ser Leu His Gly Ser Ala Ser Ile Arg Thr
245 250 255Phe Leu Thr Glu Ala Leu Thr Cys Pro Gly Val Asp Trp Asp
Arg Ile 260 265 270Asp Ala Ala Ser Cys Glu Tyr Asp Ser Cys Pro Lys
Leu Val Lys Glu 275 280 285Phe Asp Gln Thr Gly Leu Gly Asn Thr Asp
Thr Gln Ile Met Arg Glu 290 295 300Leu Glu Ala Gln Lys Glu Met Ile
Gly Lys Leu Gly Arg Asn Ile Thr305 310 315 320Asp Val Asn Asn Arg
Val Asp Ala Ile Pro Pro Gln Leu Ser Asn Ile 325 330 335Phe Ile Ser
Met Gly Val Ala Gly 340
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