U.S. patent application number 13/318221 was filed with the patent office on 2012-03-15 for recombinant virus-like particles encoded by multi-gene vector. Invention is credited to Corinne John, Christian Schaub, Sabine Wellnitz.
Application Number | 20120064115 13/318221 |
Document ID | / |
Family ID | 42544386 |
Filed Date | 2012-03-15 |
United States Patent Application | 20120064115 |
Kind Code | A1 |
John; Corinne ; et al. | March 15, 2012 |
The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.
Inventors: | John; Corinne; (Horgen, CH) ; Schaub; Christian; (Wadenswil, CH) ; Wellnitz; Sabine; (Urdorf, CH) |
Family ID: | 42544386 |
Appl. No.: | 13/318221 |
Filed: | April 30, 2010 |
PCT Filed: | April 30, 2010 |
PCT NO: | PCT/EP2010/055943 |
371 Date: | October 31, 2011 |
Current U.S. Class: | 424/202.1 ; 424/204.1; 435/252.33; 435/254.21; 435/254.22; 435/254.23; 435/320.1; 435/325; 435/348; 435/352; 435/358; 435/366; 435/367; 435/369; 435/370; 530/350 |
Current CPC Class: | C12N 2760/16134 20130101; C12N 2710/14143 20130101; C12N 2760/16123 20130101; C12N 2710/20023 20130101; A61K 2039/5258 20130101; A61P 43/00 20180101; C12N 7/00 20130101; C12N 15/86 20130101; A61K 2039/5256 20130101; A61P 31/16 20180101; A61P 31/12 20180101; A61P 31/20 20180101; C12N 2760/16023 20130101; A61P 37/04 20180101; C12N 2710/14043 20130101; C12N 2710/16123 20130101; C12N 2710/20034 20130101 |
Class at Publication: | 424/202.1 ; 530/350; 435/320.1; 435/252.33; 435/348; 435/366; 435/367; 435/369; 435/370; 435/352; 435/358; 435/325; 435/254.23; 435/254.21; 435/254.22; 424/204.1 |
International Class: | A61K 39/295 20060101 A61K039/295; C12N 15/00 20060101 C12N015/00; C12N 1/21 20060101 C12N001/21; C07K 14/11 20060101 C07K014/11; C07K 14/025 20060101 C07K014/025; A61P 31/20 20060101 A61P031/20; C12N 5/10 20060101 C12N005/10; C12N 1/19 20060101 C12N001/19; A61K 39/12 20060101 A61K039/12; A61P 37/04 20060101 A61P037/04; A61P 31/12 20060101 A61P031/12; A61P 31/16 20060101 A61P031/16; C07K 14/005 20060101 C07K014/005; C07K 14/46 20060101 C07K014/46 |
Date | Code | Application Number |
---|---|---|
May 1, 2009 | EP | 09159287.3 |
Sequence CWU 1
1
5110482DNAArtificialmulti-epitope influenza A virus-like particle
1ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt ttgtaattga
60ctgaatatca acgcttattt gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc
120attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg
ccagcgccct 180agcgcccgct cctttcgctt tcttcccttc ctttctcgcc
acgttcgccg gctttccccg 240tcaagctcta aatcgggggc tccctttagg
gttccgattt agtgctttac ggcacctcga 300ccccaaaaaa cttgattagg
gtgatggttc acgtagtggg ccatcgccct gatagacggt 360ttttcgccct
ttgacgttgg agtccacgtt cttaatagtg gactcttgtt ccaaactgga
420acaacactca accctatctc ggtctattct tttgatttat aagggatttt
gccgatttcg 480gcctattggt taaaaaatga gctgatttaa caaaaattta
acgcgaattt taacaaaata 540ttaacgctta caatttaggt ggcacttttc
ggggaaatgt gcgcggaacc cctatttgtt 600tatttttcta aatacattca
aatatgtatc cgctcatgag acaataaccc tgataaatgc 660ttcaataata
ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc
720ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg
gtgaaagtaa 780aagatgctga agatcagttg ggtgcacgag tgggttacat
cgaactggat ctcaacagcg 840gtaagatcct tgagagtttt cgccccgaag
aacgttttcc aatgatgagc acttttaaag 900ttctgctatg tggcgcggta
ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc 960gcatacacta
ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta
1020cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt
gataacactg 1080cggccaactt acttctgaca acgatcggag gaccgaagga
gctaaccgct tttttgcaca 1140acatggggga tcatgtaact cgccttgatc
gttgggaacc ggagctgaat gaagccatac 1200caaacgacga gcgtgacacc
acgatgcctg tagcaatggc aacaacgttg cgcaaactat 1260taactggcga
actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg
1320ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt
attgctgata 1380aatctggagc cggtgagcgt gggtctcgcg gtatcattgc
agcactgggg ccagatggta 1440agccctcccg tatcgtagtt atctacacga
cggggagtca ggcaactatg gatgaacgaa 1500atagacagat cgctgagata
ggtgcctcac tgattaagca ttggtaactg tcagaccaag 1560tttactcata
tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg
1620tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt
tcgttccact 1680gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg
agatcctttt tttctgcgcg 1740taatctgctg cttgcaaaca aaaaaaccac
cgctaccagc ggtggtttgt ttgccggatc 1800aagagctacc aactcttttt
ccgaaggtaa ctggcttcag cagagcgcag ataccaaata 1860ctgttcttct
agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta
1920catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat
aagtcgtgtc 1980ttaccgggtt ggactcaaga cgatagttac cggataaggc
gcagcggtcg ggctgaacgg 2040ggggttcgtg cacacagccc agcttggagc
gaacgaccta caccgaactg agatacctac 2100agcgtgagct atgagaaagc
gccacgcttc ccgaagggag aaaggcggac aggtatccgg 2160taagcggcag
ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt
2220atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt
ttgtgatgct 2280cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc
ggccttttta cggttcctgg 2340ccttttgctg gccttttgct cacatgttct
ttcctgcgtt atcccctgat tctgtggata 2400accgtattac cgcctttgag
tgagctgata ccgctcgccg cagccgaacg accgagcgca 2460gcgagtcagt
gagcgaggaa gcggaagagc gcctgatgcg gtattttctc cttacgcatc
2520tgtgcggtat ttcacaccgc atagaccagc cgcgtaacct ggcaaaatcg
gttacggttg 2580agtaataaat ggatgccctg cgtaagcggg tgtgggcgga
caataaagtc ttaaactgaa 2640caaaatagat ctaaactatg acaataaagt
cttaaactag acagaatagt tgtaaactga 2700aatcagtcca gttatgctgt
gaaaaagcat actggacttt tgttatggct aaagcaaact 2760cttcattttc
tgaagtgcaa attgcccgtc gtattaaaga ggggcgtggc caagggcatg
2820gtaaagacta tattcgcggc gttgtgacaa tttaccgaac aactccgcgg
ccgggaagcc 2880gatctcggct tgaacgaatt gttaggtggc ggtacttggg
tcgatatcaa agtgcatcac 2940ttcttcccgt atgcccaact ttgtatagag
agccactgcg ggatcgtcac cgtaatctgc 3000ttgcacgtag atcacataag
caccaagcgc gttggcctca tgcttgagga gattgatgag 3060cgcggtggca
atgccctgcc tccggtgctc gccggagact gcgagatcat agatatagat
3120ctcactacgc ggctgctcaa acttgggcag aacgtaagcc gcgagagcgc
caacaaccgc 3180ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta
cggagcaagt tcccgaggta 3240atcggagtcc ggctgatgtt gggagtaggt
ggctacgtct ccgaactcac gaccgaaaag 3300atcaagagca gcccgcatgg
atttgacttg gtcagggccg agcctacatg tgcgaatgat 3360gcccatactt
gagccaccta actttgtttt agggcgactg ccctgctgcg taacatcgtt
3420gctgctgcgt aacatcgttg ctgctccata acatcaaaca tcgacccacg
gcgtaacgcg 3480cttgctgctt ggatgcccga ggcatagact gtacaaaaaa
acagtcataa caagccatga 3540aaaccgccac tgcgccgtta ccaccgctgc
gttcggtcaa ggttctggac cagttgcgtg 3600agcgcatacg ctacttgcat
tacagtttac gaaccgaaca ggcttatgtc aactgggttc 3660gtgccttcat
ccgtttccac ggtgtgcgtc acccggcaac cttgggcagc agcgaagtcg
3720aggcatttct gtcctggctg gcgaacgagc gcaaggtttc ggtctccacg
catcgtcagg 3780cattggcggc cttgctgttc ttctacggca aggtgctgtg
cacggatctg cccttgcttc 3840aggagatcgg tagacctcgg ccgtcgcggc
gcttgccggt ggtgctgacc ccggatgaag 3900tggttcgcat cctcggtttt
ctggaaggcg agcatcgttt gttcgcccag gactctagct 3960atagttctag
tggttggcta cagctttgtt tgtactatca acaggttgaa ctgctgatca
4020acagatcctc tacgcggccg cggtaccata acttcgtata gcatacatta
tacgaagtta 4080tctggtttaa acgtacccgt agtggctatg gcagggcttg
ccgccccgac gttggctgcg 4140agccctgggc cttcacccga acttgggggt
tggggtgggg aaaaggaaga aacgcgggcg 4200tattggtccc aatggggtct
cggtggggta tcgacagagt gccagccctg ggaccgaacc 4260ccgcgtttat
gaacaaacga cccaacaccc gtgcgtttta ttctgtcttt ttattgccgt
4320catagcgcgg gttccttccg gtattgtctc cttccgtgtt tcagttagcc
tcccccatct 4380cccggtaccg catgctatgc atgcggccgc tcacttgaac
cgttgcatct gcacccccat 4440tcgtttctga taggcctgca aattttcaag
aagatcattt ttcagaccag cactggagct 4500aggatgagtc ccaatggttc
tcatcgcttg caccatttgc ctagcctgac tagcaacctc 4560catggcctct
gctgcttgct cactcgatcc agccatttgc tccatagcct tagctgtagt
4620gctggctaaa accattctgt tctcatgtct gattagtgga ttggttgttg
tcaccatttg 4680cctatgagac cgatgctggg agtcagcaat ctgttcacag
gttgcacata ccaggccaaa 4740tgccacttca gtggtcacag cccccatcct
gttgtatatg aggcccatac aactggcaag 4800tgcaccagca gaataactga
gtgagatttc tttggcccca tggaatgtta tctccctctt 4860gagcttccta
tacagtttaa ctgctttgtc catgttattt ggatccccgt tcccattaag
4920ggcagtttgg acaaagcgtc tacgctgcag tcctcgctca ctgggcacgg
tgagcgtgaa 4980cacaaatcct aaaatcccct tagtcagagg tgacaggatt
ggtcttgtct ttagccattc 5040catgagaacc tcaagatcgg tgttcttccc
tgcaaagaca tcttcaagtc tctgtgcgat 5100ctcggctttg agggggcctg
acgggatgat agagagaacg tacgtttcga cctcggttag 5160aagactcatg
gtggatccat cccgggtgat caagtcttcg tcgagtgatt gtaaataaaa
5220tgtaatttac agtatagtat tttaattaat atacaaatga tttgataata
attcttattt 5280aactataata tattgtgttg ggttgaatta aaggtccgta
tactagtatc gattcgcgac 5340ctactccgga atattaatag atcatggaga
taattaaaat gataaccatc tcgcaaataa 5400ataagtattt tactgttttc
gtaacagttt tgtaataaaa aaacctataa atattccgga 5460ttattcatac
cgtcccacca tcgggcgcgg atccaccatg aatccaaatc aaaagataat
5520aacgattggc tctgtttctc tcaccatttc cacaatatgc ttcttcatgc
aaattgccat 5580cttgataact actgtaacat tgcatttcaa gcaatatgaa
ttcaactccc ccccaaacaa 5640ccaagtgatg ctgtgtgaac caacaataat
agaaagaaac ataacagaga tagtgtatct 5700gaccaacacc accatagaga
aggaaatatg ccccaaacta gcagaataca gaaattggtc 5760aaagccgcaa
tgtgacatta caggatttgc acctttttct aaggacaatt cgattaggct
5820ttccgctggt ggggacatct gggtgacaag agaaccttat gtgtcatgcg
atcctgacaa 5880gtgttatcaa tttgcccttg gacagggaac aacactaaac
aacgtgcatt caaatgacac 5940agtacgtgat aggacccctt atcggaccct
attgatgaat gagttaggtg ttccttttca 6000tctggggacc aagcaagtgt
gcatagcatg gtccagctca agttgtcacg atggaaaagc 6060atggctgcat
gtttgtataa cgggggatga taaaaatgca actgctagct tcatttacaa
6120tgggaggctt gtagatagta ttgtttcatg gtccaaagaa atcctcagga
cccaggagtc 6180agaatgcgtt tgtatcaatg gaacttgtac agtagtaatg
actgatggga gtgcttcagg 6240aaaagctgat actaaaatac tattcattga
ggaggggaaa atcgttcata ctagcacatt 6300gtcaggaagt gctcagcatg
tcgaggagtg ctcctgctat cctcgatatc ctggtgtcag 6360atgtgtctgc
agagacaact ggaaaggctc caataggccc atcgtagata taaacataaa
6420ggatcatagc actgtttcca gttatgtgtg ttcaggactt gttggagaca
cacccagaaa 6480aaacgacagc tccagcagta gccattgttt ggatcctaac
aatgaagaag gtggtcatgg 6540agtgaaaggc tgggcctttg atgatggaaa
tgacgtgtgg atgggaagaa cgatcagcga 6600gaagtcgcgc ttagggtatg
aaaccttcaa agtcattgaa ggctggtcca accctaagtc 6660caaattgcag
ataaataggc aagtcatagt tgacagaggt aataggtccg gttattctgg
6720tattttctct gttgaaggca aaagctgcat caatcggtgc ttttatgtgg
agttgataag 6780gggaagaaaa gaggaaactg aagtcttgtg gacctcaaac
agtattgttg tgttttgtgg 6840cacctcaggt acatatggaa caggctcatg
gcctgatggg gcggacatca atctcatgcc 6900tatataagta ctagaggatc
ataatcagcc ataccacatt tgtagaggtt ttacttgctt 6960taaaaaacct
cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg
7020ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc
acaaatttca 7080caaataaagc atttttttca ctgcattcta gttgtggttt
gtccaaactc atcaatgtat 7140cttatcatgt ctggatctga tcactgcttg
agcctagaag atccggctgc taacaaagcc 7200cgaaaggaag ctgagttggc
tgctgtggct agcttatcta gaaatattaa tagatcatgg 7260agataattaa
aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag
7320ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca
ccatcgggcg 7380caccatgagt cttctaaccg aggtcgaaac gcctatcaga
aacgaatggg ggtgcagatg 7440caacggttca agtgatcctc tcactattgc
cgcaaatatc attgggatct tgcacttgac 7500attgtggatt cttgatcgtc
tttttttcaa atgcatttac cgtcgcttta aatacggact 7560gaaaggaggg
ccttctacgg aaggagtgcc aaagtctatg agggaagaat atcgaaagga
7620acagcagagt gctgtggatg ctgacgatgg tcattttgtc agcatagagc
tggagtaagt 7680actagaggat cataatcagc cataccacat ttgtagaggt
tttacttgct ttaaaaaacc 7740tcccacacct ccccctgaac ctgaaacata
aaatgaatgc aattgttgtt gttaacttgt 7800ttattgcagc ttataatggt
tacaaataaa gcaatagcat cacaaatttc acaaataaag 7860catttttttc
actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg
7920tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc
ccgaaaggaa 7980gctgagttgg ctgctgccac cgctgagcaa taactatcat
aaccggaata ttaatagatc 8040atggagataa ttaaaatgat aaccatctcg
caaataaata agtattttac tgttttcgta 8100acagttttgt aataaaaaaa
cctataaata ttccggatta ttcataccgt cccaccatcg 8160ggcgcggatc
caccatgaag actatcattg ctttgagcta cattctatgt ctggttttca
8220ctcaaaaact tcccggaaat gacaacagca cggcaacgct gtgccttggg
caccatgcag 8280taccaaacgg aacgatagtg aaaacaatca cgaatgacca
aattgaagtt actaatgcta 8340ctgagctggt tcagagttcc tcaacaggtg
aaatatgcga cagtcctcat cagatccttg 8400atggagaaaa ctgcacacta
atagatgctc tattgggaga ccctcagtgt gatggcttcc 8460aaaataagaa
atgggacctt tttgttgaac gcagcaaagc ctacagcaac tgttaccctt
8520atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc
acactggagt 8580ttaacaatga aagcttcaat tggactggag tcactcaaaa
cggaacaagc tctgcttgca 8640taaggagatc taataacagt ttctttagta
gattgaattg gttgacccac ttaaaattca 8700aatacccagc attgaacgtg
actatgccaa acaatgaaaa atttgacaaa ttgtacattt 8760ggggggttca
ccacccgggt acggacaatg accaaatctt cccgtatgct caagcatcag
8820gaagaatcac agtctctacc aaaagaagcc aacaaactgt aatcccgaat
atcggatcta 8880gacccagagt aaggaatatc cccagcagaa taagcatcta
ttggacaata gtaaaaccgg 8940gagacatact tttgattaac agcacaggga
atctaattgc tcctaggggt tacttcaaaa 9000tacgaagtgg gaaaagctca
ataatgagat cagatgcacc cattggcaaa tgcaattctg 9060aatgcatcac
tccaaacgga agcattccca atgacaaacc attccaaaat gtaaacagga
9120tcacatacgg ggcctgtccc agatatgtta agcaaaacac tctgaaattg
gcaacaggga 9180tgcgaaatgt accagagaaa caaactagag gcatatttgg
cgcaatcgcg ggtttcatag 9240aaaatggttg ggagggaatg gtggatggtt
ggtacggttt caggcatcaa aattctgagg 9300gaataggaca agcagcagat
ctcaaaagca ctcaagcagc aatcgatcaa atcaatggga 9360agctgaatag
gttgatcggg aaaaccaacg agaaattcca tcagattgaa aaagaattct
9420cagaagtcga agggagaatt caggaccttg agaaatatgt tgaggacacc
aaaatagatc 9480tctggtcata caacgcggag cttcttgttg ccctggagaa
ccaacataca attgatctaa 9540ctgactcaga aatgaacaaa ctgtttgaaa
aaacaaagaa gcaactgagg gaaaatgctg 9600aggatatggg caatggttgt
ttcaaaatat accacaaatg tgacaatgcc tgcataggat 9660caatcagaaa
tggaacttat gaccacgatg tatacagaga tgaagcatta aacaaccggt
9720tccagatcaa gggcgttgag ctgaagtcag gatacaaaga ttggatccta
tggatttcct 9780ttgccatatc atgttttttg ctttgtgttg ctttgttggg
gttcatcatg tgggcctgcc 9840aaaaaggcaa cattaggtgc aacatttgca
tttgagtact agaggatcat aatcagccat 9900accacatttg tagaggtttt
acttgcttta aaaaacctcc cacacctccc cctgaacctg 9960aaacataaaa
tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac
10020aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact
gcattctagt 10080tgtggtttgt ccaaactcat caatgtatct tatcatgtct
ggatctgatc actgcttgag 10140cctagaagat ccggctgcta acaaagcccg
aaaggaagct gagttggctg ctgccaccgc 10200tgagcaataa ctatcataac
ccctaggaga tccgaaccag ataagtgaaa tctagttcca 10260aactattttg
tcatttttaa ttttcgtatt agcttacgac gctacaccca gttcccatct
10320attttgtcac tcttccctaa ataatcctta aaaactccat ttccacccct
cccagttccc 10380aactattttg tccgcccaca gcggggcatt tttcttcctg
ttatgttttt aatcaaacat 10440cctgccaact ccatgtgaca aaccgtcatc
ttcggctact tt 1048228917DNAArtificialmulti-epitope human papilloma
virus-like particle 2ttctctgtca cagaatgaaa atttttctgt catctcttcg
ttattaatgt ttgtaattga 60ctgaatatca acgcttattt gcagcctgaa tggcgaatgg
gacgcgccct gtagcggcgc 120attaagcgcg gcgggtgtgg tggttacgcg
cagcgtgacc gctacacttg ccagcgccct 180agcgcccgct cctttcgctt
tcttcccttc ctttctcgcc acgttcgccg gctttccccg 240tcaagctcta
aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga
300ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct
gatagacggt 360ttttcgccct ttgacgttgg agtccacgtt cttaatagtg
gactcttgtt ccaaactgga 420acaacactca accctatctc ggtctattct
tttgatttat aagggatttt gccgatttcg 480gcctattggt taaaaaatga
gctgatttaa caaaaattta acgcgaattt taacaaaata 540ttaacgctta
caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt
600tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc
tgataaatgc 660ttcaataata ttgaaaaagg aagagtatga gtattcaaca
tttccgtgtc gcccttattc 720ccttttttgc ggcattttgc cttcctgttt
ttgctcaccc agaaacgctg gtgaaagtaa 780aagatgctga agatcagttg
ggtgcacgag tgggttacat cgaactggat ctcaacagcg 840gtaagatcct
tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag
900ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa
ctcggtcgcc 960gcatacacta ttctcagaat gacttggttg agtactcacc
agtcacagaa aagcatctta 1020cggatggcat gacagtaaga gaattatgca
gtgctgccat aaccatgagt gataacactg 1080cggccaactt acttctgaca
acgatcggag gaccgaagga gctaaccgct tttttgcaca 1140acatggggga
tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac
1200caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg
cgcaaactat 1260taactggcga actacttact ctagcttccc ggcaacaatt
aatagactgg atggaggcgg 1320ataaagttgc aggaccactt ctgcgctcgg
cccttccggc tggctggttt attgctgata 1380aatctggagc cggtgagcgt
gggtctcgcg gtatcattgc agcactgggg ccagatggta 1440agccctcccg
tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa
1500atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg
tcagaccaag 1560tttactcata tatactttag attgatttaa aacttcattt
ttaatttaaa aggatctagg 1620tgaagatcct ttttgataat ctcatgacca
aaatccctta acgtgagttt tcgttccact 1680gagcgtcaga ccccgtagaa
aagatcaaag gatcttcttg agatcctttt tttctgcgcg 1740taatctgctg
cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc
1800aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag
ataccaaata 1860ctgttcttct agtgtagccg tagttaggcc accacttcaa
gaactctgta gcaccgccta 1920catacctcgc tctgctaatc ctgttaccag
tggctgctgc cagtggcgat aagtcgtgtc 1980ttaccgggtt ggactcaaga
cgatagttac cggataaggc gcagcggtcg ggctgaacgg 2040ggggttcgtg
cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac
2100agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac
aggtatccgg 2160taagcggcag ggtcggaaca ggagagcgca cgagggagct
tccaggggga aacgcctggt 2220atctttatag tcctgtcggg tttcgccacc
tctgacttga gcgtcgattt ttgtgatgct 2280cgtcaggggg gcggagccta
tggaaaaacg ccagcaacgc ggccttttta cggttcctgg 2340ccttttgctg
gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata
2400accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg
accgagcgca 2460gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg
gtattttctc cttacgcatc 2520tgtgcggtat ttcacaccgc atagaccagc
cgcgtaacct ggcaaaatcg gttacggttg 2580agtaataaat ggatgccctg
cgtaagcggg tgtgggcgga caataaagtc ttaaactgaa 2640caaaatagat
ctaaactatg acaataaagt cttaaactag acagaatagt tgtaaactga
2700aatcagtcca gttatgctgt gaaaaagcat actggacttt tgttatggct
aaagcaaact 2760cttcattttc tgaagtgcaa attgcccgtc gtattaaaga
ggggcgtggc caagggcatg 2820gtaaagacta tattcgcggc gttgtgacaa
tttaccgaac aactccgcgg ccgggaagcc 2880gatctcggct tgaacgaatt
gttaggtggc ggtacttggg tcgatatcaa agtgcatcac 2940ttcttcccgt
atgcccaact ttgtatagag agccactgcg ggatcgtcac cgtaatctgc
3000ttgcacgtag atcacataag caccaagcgc gttggcctca tgcttgagga
gattgatgag 3060cgcggtggca atgccctgcc tccggtgctc gccggagact
gcgagatcat agatatagat 3120ctcactacgc ggctgctcaa acttgggcag
aacgtaagcc gcgagagcgc caacaaccgc 3180ttcttggtcg aaggcagcaa
gcgcgatgaa tgtcttacta cggagcaagt tcccgaggta 3240atcggagtcc
ggctgatgtt gggagtaggt ggctacgtct ccgaactcac gaccgaaaag
3300atcaagagca gcccgcatgg atttgacttg gtcagggccg agcctacatg
tgcgaatgat 3360gcccatactt gagccaccta actttgtttt agggcgactg
ccctgctgcg taacatcgtt 3420gctgctgcgt aacatcgttg ctgctccata
acatcaaaca tcgacccacg gcgtaacgcg 3480cttgctgctt ggatgcccga
ggcatagact gtacaaaaaa acagtcataa caagccatga 3540aaaccgccac
tgcgccgtta ccaccgctgc gttcggtcaa ggttctggac cagttgcgtg
3600agcgcatacg ctacttgcat tacagtttac gaaccgaaca ggcttatgtc
aactgggttc 3660gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac
cttgggcagc agcgaagtcg 3720aggcatttct gtcctggctg gcgaacgagc
gcaaggtttc ggtctccacg catcgtcagg 3780cattggcggc cttgctgttc
ttctacggca aggtgctgtg cacggatctg cccttgcttc 3840aggagatcgg
tagacctcgg ccgtcgcggc gcttgccggt ggtgctgacc ccggatgaag
3900tggttcgcat cctcggtttt ctggaaggcg agcatcgttt gttcgcccag
gactctagct 3960atagttctag tggttggcta cagctttgtt tgtactatca
acaggttgaa ctgctgatca 4020acagatcctc tacgcggccg cggtaccata
acttcgtata gcatacatta tacgaagtta 4080tctggtttaa acgtacccgt
agtggctatg gcagggcttg ccgccccgac gttggctgcg 4140agccctgggc
cttcacccga acttgggggt tggggtgggg aaaaggaaga aacgcgggcg
4200tattggtccc aatggggtct cggtggggta tcgacagagt gccagccctg
ggaccgaacc 4260ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta
ttctgtcttt ttattgccgt 4320catagcgcgg gttccttccg gtattgtctc
cttccgtgtt tcagttagcc tcccccatct 4380cccggtaccg catgctatgc
atatcccggg tgatcaagtc ttcgtcgagt
gattgtaaat 4440aaaatgtaat ttacagtata gtattttaat taatatacaa
atgatttgat aataattctt 4500atttaactat aatatattgt gttgggttga
attaaaggtc cgtatactag tatcgattcg 4560cgacctactc cggaatatta
atagatcatg gagataatta aaatgataac catctcgcaa 4620ataaataagt
attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc
4680cggattattc ataccgtccc accatcgggc gcggatccgc caccatgtcc
ctgtggctgc 4740cctccgaggc taccgtgtac ctgccccccg tgcccgtgtc
caaggtggtg tccaccgacg 4800agtacgtggc tcgtaccaac atctactacc
acgctggcac ctcccgtctg ctggctgtgg 4860gtcaccccta cttccccatc
aagaagccca acaacaacaa gatcctggtg cccaaggtgt 4920ccggcctgca
gtaccgtgtg ttccgtatcc acctgcccga ccccaacaag ttcggtttcc
4980ccgacacctc cttctacaac cctgacaccc agcgcctcgt gtgggcttgc
gtgggcgtgg 5040aggtcggccg tggccagccc ctgggtgtcg gtatctccgg
tcaccccctg ctgaacaagc 5100tggacgacac cgagaacgct tccgcttacg
ctgctaacgc tggtgtcgac aaccgcgagt 5160gcatctccat ggactacaag
cagacccagc tgtgcctgat cggttgcaag ccccccatcg 5220gcgagcactg
gggcaagggt tccccctgca ccaacgtggc tgtgaacccc ggcgactgcc
5280cccctctcga gctgatcaac accgtgatcc aggacggcga catggtggac
accggtttcg 5340gtgctatgga cttcaccacc ctgcaggcta acaagtccga
ggtgcccctg gacatctgca 5400cctccatctg caagtacccc gactacatca
agatggtgtc cgagccctac ggcgactccc 5460tgttcttcta cctgcgtcgt
gagcagatgt tcgtgcgtca cctgttcaac cgtgctggtg 5520ctgtgggcga
gaacgtgccc gacgacctgt acatcaaggg ttccggttcc accgctaacc
5580tggcttccag caactacttc cctaccccct ccggttccat ggtcacctcc
gacgctcaga 5640tcttcaacaa gccctactgg ctgcagcgtg ctcagggtca
caacaacggt atctgctggg 5700gcaaccagct gttcgtgacc gtggtcgaca
ccacccgttc caccaacatg tctctgtgcg 5760ctgctatctc cacctccgag
actacctaca agaacaccaa cttcaaggag tacctgcgtc 5820acggcgagga
gtacgacctg cagttcatct tccagctgtg caagatcacc ctgaccgctg
5880acgtgatgac ctacatccac tccatgaact ccactatcct cgaagattgg
aacttcggtc 5940tgcagccccc tcccggtggc accctcgagg acacctaccg
tttcgtcacc tcccaggcta 6000tcgcttgcca gaagcacacc ccccctgctc
ccaaggagga ccccctgaag aagtacacct 6060tctgggaggt caacctgaag
gagaagttct ccgctgacct ggaccagttc cccctgggtc 6120gcaagttcct
gctgcaggcc ggactgaagg ccaagcccaa gttcaccctg ggcaagcgca
6180aggctacccc caccacctcc tccacctcca ccaccgctaa gaggaagaag
cgcaagctgt 6240aaaagcttgt cgagaagtac tagaggatca taatcagcca
taccacattt gtagaggttt 6300tacttgcttt aaaaaacctc ccacacctcc
ccctgaacct gaaacataaa atgaatgcaa 6360ttgttgttgt taacttgttt
attgcagctt ataatggtta caaataaagc aatagcatca 6420caaatttcac
aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca
6480tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga
tccggctgct 6540aacaaagccc gaaaggaagc tgagttggct gctgtggcta
gctttgttta actttaagaa 6600ggagatacat ctagaaatat taatagatca
tggagataat taaaatgata accatctcgc 6660aaataaataa gtattttact
gttttcgtaa cagttttgta ataaaaaaac ctataaatat 6720tccggattat
tcataccgtc ccaccatcgg gcgcggatcc gccaccatgg ctctgtggcg
6780tccctccgac aacaccgtgt acctgccccc tccctccgtg gctcgtgtgg
tcaacaccga 6840cgactacgtg acccgtacct ccatcttcta ccacgctggt
tcctcccgtc tgctgaccgt 6900gggcaacccc tacttccgtg tgcccgctgg
cggtggcaac aagcaggaca tccccaaggt 6960gtccgcttac cagtaccgtg
tgttccgtgt gcagctgccc gaccccaaca agttcggtct 7020gcccgacacc
tccatctaca accccgagac tcagcgcctc gtgtgggctt gcgctggtgt
7080cgagatcggt cgtggccagc ccctgggtgt cggcctgtcc ggtcacccct
tctacaacaa 7140gctggacgac accgagtcct cccacgctgc tacctccaac
gtgtccgagg acgtgcgcga 7200caacgtgtct gtggactaca agcagaccca
gctgtgcatc ctgggttgcg ctcccgctat 7260cggcgagcac tgggctaagg
gcaccgcttg caagtcccgt cctctgtccc agggcgactg 7320cccccctctc
gagctgaaga acaccgtgct cgaggacggc gacatggtgg acaccggtta
7380cggtgctatg gacttcagca ccctgcagga caccaagtgc gaggtgcccc
tggacatctg 7440ccagtccatc tgcaagtacc ccgactacct gcagatgtcc
gctgacccct acggcgactc 7500tatgttcttc tgcctgcgtc gtgagcagct
gttcgctcgt cacttctgga accgtgctgg 7560caccatgggt gacaccgtgc
cccagtccct gtacatcaag ggcaccggca tgcgtgcttc 7620ccccggttcc
tgcgtgtact ccccttcccc ctccggttcc atcgtgacct ccgactccca
7680gctgttcaac aagccctact ggctgcacaa ggctcagggt cacaacaacg
gtgtctgctg 7740gcacaaccag ctgttcgtga ccgtggtcga caccacccgt
tccaccaacc tgaccatctg 7800cgcttccacc cagtcccccg tgcccggcca
gtacgacgct accaagttca agcagtactc 7860ccgtcacgtg gaggagtacg
acctgcagtt catcttccag ctctgcacta tcaccctgac 7920cgctgacgtg
atgtcctaca tccactccat gaactcctct atcctcgaag attggaactt
7980cggtgtcccc cctcccccca ctacctccct ggtggacact taccgtttcg
tgcagtccgt 8040ggctatcacc tgccagaagg acgctgctcc cgctgagaac
aaggacccct acgacaagct 8100gaagttctgg aacgtggacc tgaaggagaa
gttctccctg gacctggacc agtaccccct 8160gggtcgcaag ttcctggtgc
aggctggcct gaggcgcaag cccaccatcg gtccccgcaa 8220gcgttccgct
ccctccgcta ccacctcctc caagcccgcc aagcgtgtgc gtgtgcgcgc
8280tcgcaagtaa gctagcaagc ttgtcgagaa gtactagagg atcataatca
gccataccac 8340atttgtagag gttttacttg ctttaaaaaa cctcccacac
ctccccctga acctgaaaca 8400taaaatgaat gcaattgttg ttgttaactt
gtttattgca gcttataatg gttacaaata 8460aagcaatagc atcacaaatt
tcacaaataa agcatttttt tcactgcatt ctagttgtgg 8520tttgtccaaa
ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag
8580aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc
accgctgagc 8640aataactatc ataaccccta ggagatccga accagataag
tgaaatctag ttccaaacta 8700ttttgtcatt tttaattttc gtattagctt
acgacgctac acccagttcc catctatttt 8760gtcactcttc cctaaataat
ccttaaaaac tccatttcca cccctcccag ttcccaacta 8820ttttgtccgc
ccacagcggg gcatttttct tcctgttatg tttttaatca aacatcctgc
8880caactccatg tgacaaaccg tcatcttcgg ctacttt
8917310595DNAArtificialmulti-epitope influenza B virus-like
particle 3ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt
ttgtaattga 60ctgaatatca acgcttattt gcagcctgaa tggcgaatgg gacgcgccct
gtagcggcgc 120attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc
gctacacttg ccagcgccct 180agcgcccgct cctttcgctt tcttcccttc
ctttctcgcc acgttcgccg gctttccccg 240tcaagctcta aatcgggggc
tccctttagg gttccgattt agtgctttac ggcacctcga 300ccccaaaaaa
cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt
360ttttcgccct ttgacgttgg agtccacgtt cttaatagtg gactcttgtt
ccaaactgga 420acaacactca accctatctc ggtctattct tttgatttat
aagggatttt gccgatttcg 480gcctattggt taaaaaatga gctgatttaa
caaaaattta acgcgaattt taacaaaata 540ttaacgctta caatttaggt
ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt 600tatttttcta
aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc
660ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc
gcccttattc 720ccttttttgc ggcattttgc cttcctgttt ttgctcaccc
agaaacgctg gtgaaagtaa 780aagatgctga agatcagttg ggtgcacgag
tgggttacat cgaactggat ctcaacagcg 840gtaagatcct tgagagtttt
cgccccgaag aacgttttcc aatgatgagc acttttaaag 900ttctgctatg
tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc
960gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa
aagcatctta 1020cggatggcat gacagtaaga gaattatgca gtgctgccat
aaccatgagt gataacactg 1080cggccaactt acttctgaca acgatcggag
gaccgaagga gctaaccgct tttttgcaca 1140acatggggga tcatgtaact
cgccttgatc gttgggaacc ggagctgaat gaagccatac 1200caaacgacga
gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat
1260taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg
atggaggcgg 1320ataaagttgc aggaccactt ctgcgctcgg cccttccggc
tggctggttt attgctgata 1380aatctggagc cggtgagcgt gggtctcgcg
gtatcattgc agcactgggg ccagatggta 1440agccctcccg tatcgtagtt
atctacacga cggggagtca ggcaactatg gatgaacgaa 1500atagacagat
cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag
1560tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa
aggatctagg 1620tgaagatcct ttttgataat ctcatgacca aaatccctta
acgtgagttt tcgttccact 1680gagcgtcaga ccccgtagaa aagatcaaag
gatcttcttg agatcctttt tttctgcgcg 1740taatctgctg cttgcaaaca
aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc 1800aagagctacc
aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata
1860ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta
gcaccgccta 1920catacctcgc tctgctaatc ctgttaccag tggctgctgc
cagtggcgat aagtcgtgtc 1980ttaccgggtt ggactcaaga cgatagttac
cggataaggc gcagcggtcg ggctgaacgg 2040ggggttcgtg cacacagccc
agcttggagc gaacgaccta caccgaactg agatacctac 2100agcgtgagct
atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg
2160taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga
aacgcctggt 2220atctttatag tcctgtcggg tttcgccacc tctgacttga
gcgtcgattt ttgtgatgct 2280cgtcaggggg gcggagccta tggaaaaacg
ccagcaacgc ggccttttta cggttcctgg 2340ccttttgctg gccttttgct
cacatgttct ttcctgcgtt atcccctgat tctgtggata 2400accgtattac
cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca
2460gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg gtattttctc
cttacgcatc 2520tgtgcggtat ttcacaccgc atagaccagc cgcgtaacct
ggcaaaatcg gttacggttg 2580agtaataaat ggatgccctg cgtaagcggg
tgtgggcgga caataaagtc ttaaactgaa 2640caaaatagat ctaaactatg
acaataaagt cttaaactag acagaatagt tgtaaactga 2700aatcagtcca
gttatgctgt gaaaaagcat actggacttt tgttatggct aaagcaaact
2760cttcattttc tgaagtgcaa attgcccgtc gtattaaaga ggggcgtggc
caagggcatg 2820gtaaagacta tattcgcggc gttgtgacaa tttaccgaac
aactccgcgg ccgggaagcc 2880gatctcggct tgaacgaatt gttaggtggc
ggtacttggg tcgatatcaa agtgcatcac 2940ttcttcccgt atgcccaact
ttgtatagag agccactgcg ggatcgtcac cgtaatctgc 3000ttgcacgtag
atcacataag caccaagcgc gttggcctca tgcttgagga gattgatgag
3060cgcggtggca atgccctgcc tccggtgctc gccggagact gcgagatcat
agatatagat 3120ctcactacgc ggctgctcaa acttgggcag aacgtaagcc
gcgagagcgc caacaaccgc 3180ttcttggtcg aaggcagcaa gcgcgatgaa
tgtcttacta cggagcaagt tcccgaggta 3240atcggagtcc ggctgatgtt
gggagtaggt ggctacgtct ccgaactcac gaccgaaaag 3300atcaagagca
gcccgcatgg atttgacttg gtcagggccg agcctacatg tgcgaatgat
3360gcccatactt gagccaccta actttgtttt agggcgactg ccctgctgcg
taacatcgtt 3420gctgctgcgt aacatcgttg ctgctccata acatcaaaca
tcgacccacg gcgtaacgcg 3480cttgctgctt ggatgcccga ggcatagact
gtacaaaaaa acagtcataa caagccatga 3540aaaccgccac tgcgccgtta
ccaccgctgc gttcggtcaa ggttctggac cagttgcgtg 3600agcgcatacg
ctacttgcat tacagtttac gaaccgaaca ggcttatgtc aactgggttc
3660gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac cttgggcagc
agcgaagtcg 3720aggcatttct gtcctggctg gcgaacgagc gcaaggtttc
ggtctccacg catcgtcagg 3780cattggcggc cttgctgttc ttctacggca
aggtgctgtg cacggatctg cccttgcttc 3840aggagatcgg tagacctcgg
ccgtcgcggc gcttgccggt ggtgctgacc ccggatgaag 3900tggttcgcat
cctcggtttt ctggaaggcg agcatcgttt gttcgcccag gactctagct
3960atagttctag tggttggcta cagctttgtt tgtactatca acaggttgaa
ctgctgatca 4020acagatcctc tacgcggccg cggtaccata acttcgtata
gcatacatta tacgaagtta 4080tctggtttaa acgtacccgt agtggctatg
gcagggcttg ccgccccgac gttggctgcg 4140agccctgggc cttcacccga
acttgggggt tggggtgggg aaaaggaaga aacgcgggcg 4200tattggtccc
aatggggtct cggtggggta tcgacagagt gccagccctg ggaccgaacc
4260ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta ttctgtcttt
ttattgccgt 4320catagcgcgg gttccttccg gtattgtctc cttccgtgtt
tcagttagcc tcccccatct 4380cccggtacct tataagtatt tcctcacaag
agctgaattt cccatagagc tctgttttag 4440cacttccatt acatctttgg
caattccttc tccattcttt tgacttgctc ctagagatct 4500caacactcca
atgttgtttt gcagctcttc tgctagtttt tggacgtctt ctccctttcc
4560cattccattc attgtctttg ctgtgttcat agctgaaacc atctgcattt
ctcgtcttac 4620tccaggtacc gaagaccttg ctgctctgct atgggctcta
tgcgagtgcg atgcttgttt 4680ctcgcataaa gcacagagcg ttcctagttt
tacttgcatt gaatagtttt cagggtttag 4740gtacatgacc ataagacaat
atagtaatgc tgagctttcg tggccttctg ctatttcaaa 4800tgcttcatga
aagcttacac atcttctcat ttttctctca gctagaatta ggcctttctt
4860ctttgttgct gttgttccca ttcctgacag gggctctgtg atgaatctcc
tttttctttc 4920ttggtctttg ggttttaaaa agcatataga ggcaccaatt
agtgcttttt gtatatcagt 4980taggcacctt ttgtttttta tccattccaa
agcagaatct aggtcaaatt ctttcccacc 5040gaaccaacag tgtaattttt
cagctagttc tgctttgcct tctccatctt ctattagtga 5100aagcaggtag
gcaattgtgt ctccaaacag cgacatggtg gcatcccggg tgatcaagtc
5160ttcgtcgagt gattgtaaat aaaatgtaat ttacagtata gtattttaat
taatatacaa 5220atgatttgat aataattctt atttaactat aatatattgt
gttgggttga attaaaggtc 5280cgtatactag tatcgattcg cgacctactc
cggaatatta atagatcatg gagataatta 5340aaatgataac catctcgcaa
ataaataagt attttactgt tttcgtaaca gttttgtaat 5400aaaaaaacct
ataaatattc cggattattc ataccgtccc accatcgggc gcggatccac
5460catgaaggca ataattgtac tactcatggt agtaacatcc aatgcagatc
gaatctgcac 5520tggaataaca tcttcaaact cacctcatgt ggtcaaaaca
gccactcaag gggaggtcaa 5580tgtgactggt gtgataccac taacaacaac
accaacaaaa tcttattttg caaatctcaa 5640aggaacaagg accagaggga
aactatgccc agactgtctc aactgcacag atctggatgt 5700ggctttgggc
agaccaatgt gtgtggggac cacaccttcg gcgaaagctt caatactcca
5760cgaagtcaaa cctgttacat ccgggtgctt tcctataatg cacgacagaa
caaaaatcag 5820gcaactaccc aatcttctca gaggatatga aaatatcagg
ctatcaaccc aaaacgtcat 5880cgatgcggaa aaggcaccag gaggacccta
cagacttgga acctcaggat cttgccctaa 5940cgctaccagt aagagcggat
ttttcgcaac aatggcttgg gctgtcccaa aggacaacaa 6000caaaaatgca
acgaacccac taacagtaga agtaccatac atttgtacag aaggggaaga
6060ccaaatcact gtttgggggt tccattcaga tgacaaaacc caaatgaaga
acctctatgg 6120agactcaaat cctcaaaagt tcacctcatc tgctaatgga
gtaaccacac actatgtttc 6180tcagattggc agcttcccag atcaaacaga
agacggagga ctaccacaaa gcggcaggat 6240tgttgttgat tacatgatgc
aaaaacctgg gaaaacagga acaattgtct accaaagagg 6300tgttttgttg
cctcaaaagg tgtggtgcgc gagtggcagg agcaaagtaa taaaagggtc
6360cttgccttta attggtgaag cagattgcct tcatgaaaaa tacggtggat
taaacaaaag 6420caagccttac tacacaggag aacatgcaaa agccatagga
aattgcccaa tatgggtgaa 6480aacacctttg aagcttgcca atggaaccaa
atatagacct cctgcaaaac tattaaagga 6540aaggggtttc ttcggagcta
ttgctggttt cctagaagga ggatgggaag gaatgattgc 6600aggctggcac
ggatacacat ctcacggagc acatggagtg gcagtggcgg cggaccttaa
6660gagtacgcaa gaagctataa acaagataac aaaaaatctc aattctttga
gtgagctaga 6720agtaaagaat cttcaaagac taagtggtgc catggatgaa
ctccacaacg aaatactcga 6780gctggatgag aaagtggatg atctcagagc
tgacactata agctcgcaaa tagaacttgc 6840agtcttgctt tccaacgaag
gaataataaa cagtgaagat gagcatctat tggcacttga 6900gagaaaacta
aagaaaatgc tgggtccctc tgctgtagag ataggaaatg gatgcttcga
6960aaccaaacac aagtgcaacc agacctgctt agacaggata gctgctggca
cctttaatgc 7020aggagaattt tctctcccca cttttgattc actgaacatt
actgctgcat ctttaaatga 7080tgatggattg gataaccata ctatactgct
ctattactca actgctgctt ctagtttggc 7140tgtaacattg atgctagcta
tttttattgt ttatatggtc tccagagaca acgtttcatg 7200ctccatctgt
ctataagtcg acgtactaga ggatcataat cagccatacc acatttgtag
7260aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa
cataaaatga 7320atgcaattgt tgttgttaac ttgtttattg cagcttataa
tggttacaaa taaagcaata 7380gcatcacaaa tttcacaaat aaagcatttt
tttcactgca ttctagttgt ggtttgtcca 7440aactcatcaa tgtatcttat
catgtctgga tctgatcact gcttgagcct agaagatccg 7500gctgctaaca
aagcccgaaa ggaagctgag ttggctgctg tggctagctt tgtttaactt
7560taagaaggag atacatctag aaatattaat agatcatgga gataattaaa
atgataacca 7620tctcgcaaat aaataagtat tttactgttt tcgtaacagt
tttgtaataa aaaaacctat 7680aaatattccg gattattcat accgtcccac
catcgggcgc ggatccacca tgctaccttc 7740aactatacaa acgttaaccc
tatttctcac atcaggggga gtgttattat cactatatgt 7800gtcagcttca
ttgtcatact tactatattc ggatatattg ctaaaatttt cacaaacaga
7860aataactgca ccaataatgc cattggattg tgcaaacgca tcaaatgttc
aggctgtgaa 7920ccgttctgca gcaaaagggg tgacacttct tctcccagaa
ccggagtgga cataccctcg 7980tttatcttgc ccgggctcaa cctttcagaa
agcactccta attagccccc atagattcgg 8040agaaaccaaa ggaaactcag
ctcccttgat aataagggaa ccttttattg cttgtggacc 8100aacggaatgc
aaacactttg ctctaaccca ttatgcagct caaccagggg gatactacaa
8160tggaacaaga gaagacagaa acaagctgag gcatctaatt tcagtcaaat
tgggcaaaat 8220cccaacagta gaaaactcca ttttccatat ggcagcttgg
agcgggtccg catgccatga 8280tggtaaagaa tggacatata tcggagttga
tggccccgac agtaatgcat tactcaaaat 8340aaaatatgga gaagcatata
ctgacacata ccattcctat gcaaaaaaca tcctaaggac 8400acaagaaagt
gcctgcaatt gcatcggggg agattgttat cttatgataa ctgatggccc
8460agcttcaggg attagtgaat gcagattcct taagattcga gagggccgaa
taataaaaga 8520aatatttcca acaggaagag taaaacatac tgaggaatgc
acatgcggat ttgccagcaa 8580caaaaccata gaatgtgctt gtagagataa
cagttacaca gcaaaaagac cctttgtcaa 8640attaaatgtg gagactgata
cagcggaaat aagattgatg tgcacagaga cttatttgga 8700cacccccaga
ccaaatgatg gaagcataac agggccttgc gaatctgatg gggacaaagg
8760gagtggaggc atcaagggag gatttgttca tcaaagaatg gcatccaaga
ttggaaggtg 8820gtactctcga acgatgtcta aaactaaaag aatggggatg
ggactgtatg taaagtatga 8880tggagaccca tggactgaca gtgaagccct
tgctcttagt ggagtaatgg tttcgatgga 8940agaacctggt tggtattcct
ttggcttcga aataaaagat aagaaatgtg atgtcccctg 9000tattgggata
gaaatggtac atgatggtgg gaaaacgact tggcactcag cagcaacagc
9060catttactgt ttaatgggct caggacaact gctgtgggac actgtcacag
gtgttgatat 9120ggctctgtaa atcgatgaca agcttgtcga gaagtactag
aggatcataa tcagccatac 9180cacatttgta gaggttttac ttgctttaaa
aaacctccca cacctccccc tgaacctgaa 9240acataaaatg aatgcaattg
ttgttgttaa cttgtttatt gcagcttata atggttacaa 9300ataaagcaat
agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg
9360tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac
tgcttgagcc 9420tagaagatcc ggctgctaac aaagcccgaa aggaagctga
gttggctgct gggtgcctaa 9480tgagtgagct aactcacatt aattgcccgg
aatattaata gatcatggag ataattaaaa 9540tgataaccat ctcgcaaata
aataagtatt ttactgtttt cgtaacagtt ttgtaataaa 9600aaaacctata
aatattccgg attattcata ccgtcccacc atcgggcgcg gatccaccat
9660gctcgaacca tttcagattc tttcaatttg ttcttttatc ttatcagctc
tccatttcat 9720ggcttggaca atagggcatt tgaatcaaat aaaaagagga
ataaacatga aaatacgaat 9780aaaaggtcca aacaaagaga caataaacag
agaggtatca attttgagac acagttacca 9840aaaagaaatc caggccaaag
aaacaatgaa ggaagtactc tctgacaaca tggaggtgtt 9900gagtgaccac
ataataattg aggggctttc tgccgaagag ataataaaaa tgggtgaaac
9960agttttggag atagaagaat tgcattaagt actagaggat cataatcagc
cataccacat 10020ttgtagaggt tttacttgct ttaaaaaacc tcccacacct
ccccctgaac ctgaaacata 10080aaatgaatgc aattgttgtt gttaacttgt
ttattgcagc ttataatggt tacaaataaa 10140gcaatagcat cacaaatttc
acaaataaag catttttttc actgcattct agttgtggtt 10200tgtccaaact
catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa
10260gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac
cgctgagcaa 10320taactatcat aacccctagg agatccgaac cagataagtg
aaatctagtt ccaaactatt 10380ttgtcatttt taattttcgt attagcttac
gacgctacac ccagttccca tctattttgt 10440cactcttccc taaataatcc
ttaaaaactc catttccacc cctcccagtt
cccaactatt 10500ttgtccgccc acagcggggc atttttcttc ctgttatgtt
tttaatcaaa catcctgcca 10560actccatgtg acaaaccgtc atcttcggct acttt
1059548411DNAArtificialmulti-epitope papilloma virus-like particle
4ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt ttgtaattga
60ctgaatatca acgcttattt gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc
120attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg
ccagcgccct 180agcgcccgct cctttcgctt tcttcccttc ctttctcgcc
acgttcgccg gctttccccg 240tcaagctcta aatcgggggc tccctttagg
gttccgattt agtgctttac ggcacctcga 300ccccaaaaaa cttgattagg
gtgatggttc acgtagtggg ccatcgccct gatagacggt 360ttttcgccct
ttgacgttgg agtccacgtt cttaatagtg gactcttgtt ccaaactgga
420acaacactca accctatctc ggtctattct tttgatttat aagggatttt
gccgatttcg 480gcctattggt taaaaaatga gctgatttaa caaaaattta
acgcgaattt taacaaaata 540ttaacgctta caatttaggt ggcacttttc
ggggaaatgt gcgcggaacc cctatttgtt 600tatttttcta aatacattca
aatatgtatc cgctcatgag acaataaccc tgataaatgc 660ttcaataata
ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc
720ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg
gtgaaagtaa 780aagatgctga agatcagttg ggtgcacgag tgggttacat
cgaactggat ctcaacagcg 840gtaagatcct tgagagtttt cgccccgaag
aacgttttcc aatgatgagc acttttaaag 900ttctgctatg tggcgcggta
ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc 960gcatacacta
ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta
1020cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt
gataacactg 1080cggccaactt acttctgaca acgatcggag gaccgaagga
gctaaccgct tttttgcaca 1140acatggggga tcatgtaact cgccttgatc
gttgggaacc ggagctgaat gaagccatac 1200caaacgacga gcgtgacacc
acgatgcctg tagcaatggc aacaacgttg cgcaaactat 1260taactggcga
actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg
1320ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt
attgctgata 1380aatctggagc cggtgagcgt gggtctcgcg gtatcattgc
agcactgggg ccagatggta 1440agccctcccg tatcgtagtt atctacacga
cggggagtca ggcaactatg gatgaacgaa 1500atagacagat cgctgagata
ggtgcctcac tgattaagca ttggtaactg tcagaccaag 1560tttactcata
tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg
1620tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt
tcgttccact 1680gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg
agatcctttt tttctgcgcg 1740taatctgctg cttgcaaaca aaaaaaccac
cgctaccagc ggtggtttgt ttgccggatc 1800aagagctacc aactcttttt
ccgaaggtaa ctggcttcag cagagcgcag ataccaaata 1860ctgttcttct
agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta
1920catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat
aagtcgtgtc 1980ttaccgggtt ggactcaaga cgatagttac cggataaggc
gcagcggtcg ggctgaacgg 2040ggggttcgtg cacacagccc agcttggagc
gaacgaccta caccgaactg agatacctac 2100agcgtgagct atgagaaagc
gccacgcttc ccgaagggag aaaggcggac aggtatccgg 2160taagcggcag
ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt
2220atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt
ttgtgatgct 2280cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc
ggccttttta cggttcctgg 2340ccttttgctg gccttttgct cacatgttct
ttcctgcgtt atcccctgat tctgtggata 2400accgtattac cgcctttgag
tgagctgata ccgctcgccg cagccgaacg accgagcgca 2460gcgagtcagt
gagcgaggaa gcggaagagc gcctgatgcg gtattttctc cttacgcatc
2520tgtgcggtat ttcacaccgc atagaccagc cgcgtaacct ggcaaaatcg
gttacggttg 2580agtaataaat ggatgccctg cgtaagcggg tgtgggcgga
caataaagtc ttaaactgaa 2640caaaatagat ctaaactatg acaataaagt
cttaaactag acagaatagt tgtaaactga 2700aatcagtcca gttatgctgt
gaaaaagcat actggacttt tgttatggct aaagcaaact 2760cttcattttc
tgaagtgcaa attgcccgtc gtattaaaga ggggcgtggc caagggcatg
2820gtaaagacta tattcgcggc gttgtgacaa tttaccgaac aactccgcgg
ccgggaagcc 2880gatctcggct tgaacgaatt gttaggtggc ggtacttggg
tcgatatcaa agtgcatcac 2940ttcttcccgt atgcccaact ttgtatagag
agccactgcg ggatcgtcac cgtaatctgc 3000ttgcacgtag atcacataag
caccaagcgc gttggcctca tgcttgagga gattgatgag 3060cgcggtggca
atgccctgcc tccggtgctc gccggagact gcgagatcat agatatagat
3120ctcactacgc ggctgctcaa acttgggcag aacgtaagcc gcgagagcgc
caacaaccgc 3180ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta
cggagcaagt tcccgaggta 3240atcggagtcc ggctgatgtt gggagtaggt
ggctacgtct ccgaactcac gaccgaaaag 3300atcaagagca gcccgcatgg
atttgacttg gtcagggccg agcctacatg tgcgaatgat 3360gcccatactt
gagccaccta actttgtttt agggcgactg ccctgctgcg taacatcgtt
3420gctgctgcgt aacatcgttg ctgctccata acatcaaaca tcgacccacg
gcgtaacgcg 3480cttgctgctt ggatgcccga ggcatagact gtacaaaaaa
acagtcataa caagccatga 3540aaaccgccac tgcgccgtta ccaccgctgc
gttcggtcaa ggttctggac cagttgcgtg 3600agcgcatacg ctacttgcat
tacagtttac gaaccgaaca ggcttatgtc aactgggttc 3660gtgccttcat
ccgtttccac ggtgtgcgtc acccggcaac cttgggcagc agcgaagtcg
3720aggcatttct gtcctggctg gcgaacgagc gcaaggtttc ggtctccacg
catcgtcagg 3780cattggcggc cttgctgttc ttctacggca aggtgctgtg
cacggatctg cccttgcttc 3840aggagatcgg tagacctcgg ccgtcgcggc
gcttgccggt ggtgctgacc ccggatgaag 3900tggttcgcat cctcggtttt
ctggaaggcg agcatcgttt gttcgcccag gactctagct 3960atagttctag
tggttggcta cagctttgtt tgtactatca acaggttgaa ctgctgatca
4020acagatcctc tacgcggccg cggtaccata acttcgtata gcatacatta
tacgaagtta 4080tctggtttaa acgtacccgt agtggctatg gcagggcttg
ccgccccgac gttggctgcg 4140agccctgggc cttcacccga acttgggggt
tggggtgggg aaaaggaaga aacgcgggcg 4200tattggtccc aatggggtct
cggtggggta tcgacagagt gccagccctg ggaccgaacc 4260ccgcgtttat
gaacaaacga cccaacaccc gtgcgtttta ttctgtcttt ttattgccgt
4320catagcgcgg gttccttccg gtattgtctc cttccgtgtt tcagttagcc
tcccccatct 4380cccggtaccg catgctatgc ataagctttt acagcttgcg
cttcttcctc ttagcggtgg 4440tggaggtgga ggaggtggtg ggggtagcct
tgcgcttgcc cagggtgaac ttgggcttgg 4500ccttcagtcc ggcctgcagc
aggaacttgc gacccagggg gaactggtcc aggtcagcgg 4560agaacttctc
cttcaggttg acctcccaga aggtgtactt cttcaggggg tcctccttgg
4620gagcaggggg ggtgtgcttc tggcaagcga tagcctggga ggtgacgaaa
cggtaggtgt 4680cctcgagggt gccaccggga gggggctgca gaccgaagtt
ccaatcttcg aggatagtgg 4740agttcatgga gtggatgtag gtcatcacgt
cagcggtcag ggtgatcttg cacagctgga 4800agatgaactg caggtcgtac
tcctcgccgt gacgcaggta ctccttgaag ttggtgttct 4860tgtaggtagt
ctcggaggtg gagatagcag cgcacagaga catgttggtg gaacgggtgg
4920tgtcgaccac ggtcacgaac agctggttgc cccagcagat accgttgttg
tgaccctgag 4980cacgctgcag ccagtagggc ttgttgaaga tctgagcgtc
ggaggtgacc atggaaccgg 5040agggggtagg gaagtagttg ctggaagcca
ggttagcggt ggaaccggaa cccttgatgt 5100acaggtcgtc gggcacgttc
tcgcccacag caccagcacg gttgaacagg tgacgcacga 5160acatctgctc
acgacgcagg tagaagaaca gggagtcgcc gtagggctcg gacaccatct
5220tgatgtagtc ggggtacttg cagatggagg tgcagatgtc caggggcacc
tcggacttgt 5280tagcctgcag ggtggtgaag tccatagcac cgaaaccggt
gtccaccatg tcgccgtcct 5340ggatcacggt gttgatcagc tcgagagggg
ggcagtcgcc ggggttcaca gccacgttgg 5400tgcaggggga acccttgccc
cagtgctcgc cgatgggggg cttgcaaccg atcaggcaca 5460gctgggtctg
cttgtagtcc atggagatgc actcgcggtt gtcgacacca gcgttagcag
5520cgtaagcgga agcgttctcg gtgtcgtcca gcttgttcag cagggggtga
ccggagatac 5580cgacacccag gggctggcca cggccgacct ccacgcccac
gcaagcccac acgaggcgct 5640gggtgtcagg gttgtagaag gaggtgtcgg
ggaaaccgaa cttgttgggg tcgggcaggt 5700ggatacggaa cacacggtac
tgcaggccgg acaccttggg caccaggatc ttgttgttgt 5760tgggcttctt
gatggggaag taggggtgac ccacagccag cagacgggag gtgccagcgt
5820ggtagtagat gttggtacga gccacgtact cgtcggtgga caccaccttg
gacacgggca 5880cggggggcag gtacacggta gcctcggagg gcagccacag
ggacatggtg gcggatccat 5940cccgggtgat caagtcttcg tcgagtgatt
gtaaataaaa tgtaatttac agtatagtat 6000tttaattaat atacaaatga
tttgataata attcttattt aactataata tattgtgttg 6060ggttgaatta
aaggtccgta tactagtatc gattcgcgac ctactccgga atattaatag
6120atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt
tactgttttc 6180gtaacagttt tgtaataaaa aaacctataa atattccgga
ttattcatac cgtcccacca 6240tcgggcgcgg atccgccacc atggctctgt
ggcgtccctc cgacaacacc gtgtacctgc 6300cccctccctc cgtggctcgt
gtggtcaaca ccgacgacta cgtgacccgt acctccatct 6360tctaccacgc
tggttcctcc cgtctgctga ccgtgggcaa cccctacttc cgtgtgcccg
6420ctggcggtgg caacaagcag gacatcccca aggtgtccgc ttaccagtac
cgtgtgttcc 6480gtgtgcagct gcccgacccc aacaagttcg gtctgcccga
cacctccatc tacaaccccg 6540agactcagcg cctcgtgtgg gcttgcgctg
gtgtcgagat cggtcgtggc cagcccctgg 6600gtgtcggcct gtccggtcac
cccttctaca acaagctgga cgacaccgag tcctcccacg 6660ctgctacctc
caacgtgtcc gaggacgtgc gcgacaacgt gtctgtggac tacaagcaga
6720cccagctgtg catcctgggt tgcgctcccg ctatcggcga gcactgggct
aagggcaccg 6780cttgcaagtc ccgtcctctg tcccagggcg actgcccccc
tctcgagctg aagaacaccg 6840tgctcgagga cggcgacatg gtggacaccg
gttacggtgc tatggacttc agcaccctgc 6900aggacaccaa gtgcgaggtg
cccctggaca tctgccagtc catctgcaag taccccgact 6960acctgcagat
gtccgctgac ccctacggcg actctatgtt cttctgcctg cgtcgtgagc
7020agctgttcgc tcgtcacttc tggaaccgtg ctggcaccat gggtgacacc
gtgccccagt 7080ccctgtacat caagggcacc ggcatgcgtg cttcccccgg
ttcctgcgtg tactcccctt 7140ccccctccgg ttccatcgtg acctccgact
cccagctgtt caacaagccc tactggctgc 7200acaaggctca gggtcacaac
aacggtgtct gctggcacaa ccagctgttc gtgaccgtgg 7260tcgacaccac
ccgttccacc aacctgacca tctgcgcttc cacccagtcc cccgtgcccg
7320gccagtacga cgctaccaag ttcaagcagt actcccgtca cgtggaggag
tacgacctgc 7380agttcatctt ccagctctgc actatcaccc tgaccgctga
cgtgatgtcc tacatccact 7440ccatgaactc ctctatcctc gaagattgga
acttcggtgt cccccctccc cccactacct 7500ccctggtgga cacttaccgt
ttcgtgcagt ccgtggctat cacctgccag aaggacgctg 7560ctcccgctga
gaacaaggac ccctacgaca agctgaagtt ctggaacgtg gacctgaagg
7620agaagttctc cctggacctg gaccagtacc ccctgggtcg caagttcctg
gtgcaggctg 7680gcctgaggcg caagcccacc atcggtcccc gcaagcgttc
cgctccctcc gctaccacct 7740cctccaagcc cgccaagcgt gtgcgtgtgc
gcgctcgcaa gtaagctagc aagcttgtcg 7800agaagtacta gaggatcata
atcagccata ccacatttgt agaggtttta cttgctttaa 7860aaaacctccc
acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta
7920acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca
aatttcacaa 7980ataaagcatt tttttcactg cattctagtt gtggtttgtc
caaactcatc aatgtatctt 8040atcatgtctg gatctgatca ctgcttgagc
ctagaagatc cggctgctaa caaagcccga 8100aaggaagctg agttggctgc
tgccaccgct gagcaataac tatcataacc cctaggagat 8160ccgaaccaga
taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta
8220gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa
taatccttaa 8280aaactccatt tccacccctc ccagttccca actattttgt
ccgcccacag cggggcattt 8340ttcttcctgt tatgttttta atcaaacatc
ctgccaactc catgtgacaa accgtcatct 8400tcggctactt t
841158445DNAArtificialmulti-epitope papilloma virus-like particle
5ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt ttgtaattga
60ctgaatatca acgcttattt gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc
120attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg
ccagcgccct 180agcgcccgct cctttcgctt tcttcccttc ctttctcgcc
acgttcgccg gctttccccg 240tcaagctcta aatcgggggc tccctttagg
gttccgattt agtgctttac ggcacctcga 300ccccaaaaaa cttgattagg
gtgatggttc acgtagtggg ccatcgccct gatagacggt 360ttttcgccct
ttgacgttgg agtccacgtt cttaatagtg gactcttgtt ccaaactgga
420acaacactca accctatctc ggtctattct tttgatttat aagggatttt
gccgatttcg 480gcctattggt taaaaaatga gctgatttaa caaaaattta
acgcgaattt taacaaaata 540ttaacgctta caatttaggt ggcacttttc
ggggaaatgt gcgcggaacc cctatttgtt 600tatttttcta aatacattca
aatatgtatc cgctcatgag acaataaccc tgataaatgc 660ttcaataata
ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc
720ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg
gtgaaagtaa 780aagatgctga agatcagttg ggtgcacgag tgggttacat
cgaactggat ctcaacagcg 840gtaagatcct tgagagtttt cgccccgaag
aacgttttcc aatgatgagc acttttaaag 900ttctgctatg tggcgcggta
ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc 960gcatacacta
ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta
1020cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt
gataacactg 1080cggccaactt acttctgaca acgatcggag gaccgaagga
gctaaccgct tttttgcaca 1140acatggggga tcatgtaact cgccttgatc
gttgggaacc ggagctgaat gaagccatac 1200caaacgacga gcgtgacacc
acgatgcctg tagcaatggc aacaacgttg cgcaaactat 1260taactggcga
actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg
1320ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt
attgctgata 1380aatctggagc cggtgagcgt gggtctcgcg gtatcattgc
agcactgggg ccagatggta 1440agccctcccg tatcgtagtt atctacacga
cggggagtca ggcaactatg gatgaacgaa 1500atagacagat cgctgagata
ggtgcctcac tgattaagca ttggtaactg tcagaccaag 1560tttactcata
tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg
1620tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt
tcgttccact 1680gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg
agatcctttt tttctgcgcg 1740taatctgctg cttgcaaaca aaaaaaccac
cgctaccagc ggtggtttgt ttgccggatc 1800aagagctacc aactcttttt
ccgaaggtaa ctggcttcag cagagcgcag ataccaaata 1860ctgttcttct
agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta
1920catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat
aagtcgtgtc 1980ttaccgggtt ggactcaaga cgatagttac cggataaggc
gcagcggtcg ggctgaacgg 2040ggggttcgtg cacacagccc agcttggagc
gaacgaccta caccgaactg agatacctac 2100agcgtgagct atgagaaagc
gccacgcttc ccgaagggag aaaggcggac aggtatccgg 2160taagcggcag
ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt
2220atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt
ttgtgatgct 2280cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc
ggccttttta cggttcctgg 2340ccttttgctg gccttttgct cacatgttct
ttcctgcgtt atcccctgat tctgtggata 2400accgtattac cgcctttgag
tgagctgata ccgctcgccg cagccgaacg accgagcgca 2460gcgagtcagt
gagcgaggaa gcggaagagc gcctgatgcg gtattttctc cttacgcatc
2520tgtgcggtat ttcacaccgc atagaccagc cgcgtaacct ggcaaaatcg
gttacggttg 2580agtaataaat ggatgccctg cgtaagcggg tgtgggcgga
caataaagtc ttaaactgaa 2640caaaatagat ctaaactatg acaataaagt
cttaaactag acagaatagt tgtaaactga 2700aatcagtcca gttatgctgt
gaaaaagcat actggacttt tgttatggct aaagcaaact 2760cttcattttc
tgaagtgcaa attgcccgtc gtattaaaga ggggcgtggc caagggcatg
2820gtaaagacta tattcgcggc gttgtgacaa tttaccgaac aactccgcgg
ccgggaagcc 2880gatctcggct tgaacgaatt gttaggtggc ggtacttggg
tcgatatcaa agtgcatcac 2940ttcttcccgt atgcccaact ttgtatagag
agccactgcg ggatcgtcac cgtaatctgc 3000ttgcacgtag atcacataag
caccaagcgc gttggcctca tgcttgagga gattgatgag 3060cgcggtggca
atgccctgcc tccggtgctc gccggagact gcgagatcat agatatagat
3120ctcactacgc ggctgctcaa acttgggcag aacgtaagcc gcgagagcgc
caacaaccgc 3180ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta
cggagcaagt tcccgaggta 3240atcggagtcc ggctgatgtt gggagtaggt
ggctacgtct ccgaactcac gaccgaaaag 3300atcaagagca gcccgcatgg
atttgacttg gtcagggccg agcctacatg tgcgaatgat 3360gcccatactt
gagccaccta actttgtttt agggcgactg ccctgctgcg taacatcgtt
3420gctgctgcgt aacatcgttg ctgctccata acatcaaaca tcgacccacg
gcgtaacgcg 3480cttgctgctt ggatgcccga ggcatagact gtacaaaaaa
acagtcataa caagccatga 3540aaaccgccac tgcgccgtta ccaccgctgc
gttcggtcaa ggttctggac cagttgcgtg 3600agcgcatacg ctacttgcat
tacagtttac gaaccgaaca ggcttatgtc aactgggttc 3660gtgccttcat
ccgtttccac ggtgtgcgtc acccggcaac cttgggcagc agcgaagtcg
3720aggcatttct gtcctggctg gcgaacgagc gcaaggtttc ggtctccacg
catcgtcagg 3780cattggcggc cttgctgttc ttctacggca aggtgctgtg
cacggatctg cccttgcttc 3840aggagatcgg tagacctcgg ccgtcgcggc
gcttgccggt ggtgctgacc ccggatgaag 3900tggttcgcat cctcggtttt
ctggaaggcg agcatcgttt gttcgcccag gactctagct 3960atagttctag
tggttggcta cagctttgtt tgtactatca acaggttgaa ctgctgatca
4020acagatcctc tacgcggccg cggtaccata acttcgtata gcatacatta
tacgaagtta 4080tctggtttcg acctactccg gaatattaat agatcatgga
gataattaaa atgataacca 4140tctcgcaaat aaataagtat tttactgttt
tcgtaacagt tttgtaataa aaaaacctat 4200aaatattccg gattattcat
accgtcccac catcgggcgc ggatccgcca ccatgtccct 4260gtggctgccc
tccgaggcta ccgtgtacct gccccccgtg cccgtgtcca aggtggtgtc
4320caccgacgag tacgtggctc gtaccaacat ctactaccac gctggcacct
cccgtctgct 4380ggctgtgggt cacccctact tccccatcaa gaagcccaac
aacaacaaga tcctggtgcc 4440caaggtgtcc ggcctgcagt accgtgtgtt
ccgtatccac ctgcccgacc ccaacaagtt 4500cggtttcccc gacacctcct
tctacaaccc tgacacccag cgcctcgtgt gggcttgcgt 4560gggcgtggag
gtcggccgtg gccagcccct gggtgtcggt atctccggtc accccctgct
4620gaacaagctg gacgacaccg agaacgcttc cgcttacgct gctaacgctg
gtgtcgacaa 4680ccgcgagtgc atctccatgg actacaagca gacccagctg
tgcctgatcg gttgcaagcc 4740ccccatcggc gagcactggg gcaagggttc
cccctgcacc aacgtggctg tgaaccccgg 4800cgactgcccc cctctcgagc
tgatcaacac cgtgatccag gacggcgaca tggtggacac 4860cggtttcggt
gctatggact tcaccaccct gcaggctaac aagtccgagg tgcccctgga
4920catctgcacc tccatctgca agtaccccga ctacatcaag atggtgtccg
agccctacgg 4980cgactccctg ttcttctacc tgcgtcgtga gcagatgttc
gtgcgtcacc tgttcaaccg 5040tgctggtgct gtgggcgaga acgtgcccga
cgacctgtac atcaagggtt ccggttccac 5100cgctaacctg gcttccagca
actacttccc taccccctcc ggttccatgg tcacctccga 5160cgctcagatc
ttcaacaagc cctactggct gcagcgtgct cagggtcaca acaacggtat
5220ctgctggggc aaccagctgt tcgtgaccgt ggtcgacacc acccgttcca
ccaacatgtc 5280tctgtgcgct gctatctcca cctccgagac tacctacaag
aacaccaact tcaaggagta 5340cctgcgtcac ggcgaggagt acgacctgca
gttcatcttc cagctgtgca agatcaccct 5400gaccgctgac gtgatgacct
acatccactc catgaactcc actatcctcg aagattggaa 5460cttcggtctg
cagccccctc ccggtggcac cctcgaggac acctaccgtt tcgtcacctc
5520ccaggctatc gcttgccaga agcacacccc ccctgctccc aaggaggacc
ccctgaagaa 5580gtacaccttc tgggaggtca acctgaagga gaagttctcc
gctgacctgg accagttccc 5640cctgggtcgc aagttcctgc tgcaggccgg
actgaaggcc aagcccaagt tcaccctggg 5700caagcgcaag gctaccccca
ccacctcctc cacctccacc accgctaaga ggaagaagcg 5760caagctgtaa
aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt
5820agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga
aacataaaat 5880gaatgcaatt gttgttgtta acttgtttat tgcagcttat
aatggttaca aataaagcaa 5940tagcatcaca aatttcacaa ataaagcatt
tttttcactg cattctagtt gtggtttgtc 6000caaactcatc aatgtatctt
atcatgtctg gatctgatca ctgcttgagc ctagaagatc 6060cggctgctaa
caaagcccga aaggaagctg agttggctgc tgtggctagc tttgtttaac
6120tttaagaagg agatacatct agaaatatta atagatcatg gagataatta
aaatgataac 6180catctcgcaa ataaataagt attttactgt tttcgtaaca
gttttgtaat aaaaaaacct 6240ataaatattc cggattattc ataccgtccc
accatcgggc gcggatccgc caccatggct 6300ctgtggcgtc cctccgacaa
caccgtgtac ctgccccctc cctccgtggc
tcgtgtggtc 6360aacaccgacg actacgtgac ccgtacctcc atcttctacc
acgctggttc ctcccgtctg 6420ctgaccgtgg gcaaccccta cttccgtgtg
cccgctggcg gtggcaacaa gcaggacatc 6480cccaaggtgt ccgcttacca
gtaccgtgtg ttccgtgtgc agctgcccga ccccaacaag 6540ttcggtctgc
ccgacacctc catctacaac cccgagactc agcgcctcgt gtgggcttgc
6600gctggtgtcg agatcggtcg tggccagccc ctgggtgtcg gcctgtccgg
tcaccccttc 6660tacaacaagc tggacgacac cgagtcctcc cacgctgcta
cctccaacgt gtccgaggac 6720gtgcgcgaca acgtgtctgt ggactacaag
cagacccagc tgtgcatcct gggttgcgct 6780cccgctatcg gcgagcactg
ggctaagggc accgcttgca agtcccgtcc tctgtcccag 6840ggcgactgcc
cccctctcga gctgaagaac accgtgctcg aggacggcga catggtggac
6900accggttacg gtgctatgga cttcagcacc ctgcaggaca ccaagtgcga
ggtgcccctg 6960gacatctgcc agtccatctg caagtacccc gactacctgc
agatgtccgc tgacccctac 7020ggcgactcta tgttcttctg cctgcgtcgt
gagcagctgt tcgctcgtca cttctggaac 7080cgtgctggca ccatgggtga
caccgtgccc cagtccctgt acatcaaggg caccggcatg 7140cgtgcttccc
ccggttcctg cgtgtactcc ccttccccct ccggttccat cgtgacctcc
7200gactcccagc tgttcaacaa gccctactgg ctgcacaagg ctcagggtca
caacaacggt 7260gtctgctggc acaaccagct gttcgtgacc gtggtcgaca
ccacccgttc caccaacctg 7320accatctgcg cttccaccca gtcccccgtg
cccggccagt acgacgctac caagttcaag 7380cagtactccc gtcacgtgga
ggagtacgac ctgcagttca tcttccagct ctgcactatc 7440accctgaccg
ctgacgtgat gtcctacatc cactccatga actcctctat cctcgaagat
7500tggaacttcg gtgtcccccc tccccccact acctccctgg tggacactta
ccgtttcgtg 7560cagtccgtgg ctatcacctg ccagaaggac gctgctcccg
ctgagaacaa ggacccctac 7620gacaagctga agttctggaa cgtggacctg
aaggagaagt tctccctgga cctggaccag 7680taccccctgg gtcgcaagtt
cctggtgcag gctggcctga ggcgcaagcc caccatcggt 7740ccccgcaagc
gttccgctcc ctccgctacc acctcctcca agcccgccaa gcgtgtgcgt
7800gtgcgcgctc gcaagtaagc tagcaagctt gtcgagaagt actagaggat
cataatcagc 7860cataccacat ttgtagaggt tttacttgct ttaaaaaacc
tcccacacct ccccctgaac 7920ctgaaacata aaatgaatgc aattgttgtt
gttaacttgt ttattgcagc ttataatggt 7980tacaaataaa gcaatagcat
cacaaatttc acaaataaag catttttttc actgcattct 8040agttgtggtt
tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt
8100gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg
ctgctgccac 8160cgctgagcaa taactatcat aacccctagg agatccgaac
cagataagtg aaatctagtt 8220ccaaactatt ttgtcatttt taattttcgt
attagcttac gacgctacac ccagttccca 8280tctattttgt cactcttccc
taaataatcc ttaaaaactc catttccacc cctcccagtt 8340cccaactatt
ttgtccgccc acagcggggc atttttcttc ctgttatgtt tttaatcaaa
8400catcctgcca actccatgtg acaaaccgtc atcttcggct acttt 8445
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